Studying vascular progenitor cells in a neonatal mouse model.
While many murine models have been developed to study adult disease, animal research focused on neonatal and pediatric medicine has been limited by the small size of the mouse pups. Several transplantation, injection, and implantation systems have been used to study the function and role of vascular progenitor populations in adult mice; however, such techniques have been difficult to translate into newborn animals. Herein, we describe a model of neonatal murine intravascular injections that opens opportunity to study many diseases unique to the newborn that might benefit from vascular repair strategies and regenerative medicine.
Division of Neonatology, Department of Pediatrics, Baylor College of Medicine, Houston, TX, USA. kirstena@bcm.edu
Kirsten A
KA
Kienstra
Karen K
KK
Hirschi
D000818:Animals; D042783:Endothelial Cells / Q000166:cytology*; D004730:Endothelium, Vascular / Q000166:cytology*; D007275:Injections, Intravenous; D051379:Mice; D033581:Stem Cell Transplantation / Q000379:methods*; D013234:Stem Cells / Q000166:cytology*