RNA inhibition highlights cyclin D1 as a potential therapeutic target for mantle cell lymphoma.
Mantle cell lymphoma is characterized by a genetic translocation results in aberrant overexpression of the CCND1 gene, which encodes cyclin D1. This protein functions as a regulator of the cell cycle progression, hence is considered to play an important role in the pathogenesis of the disease. In this study, we used RNA interference strategies to examine whether cyclin D1 might serve as a therapeutic target for mantle cell lymphoma. Knocking down cyclin D1 resulted in significant growth retardation, cell cycle arrest, and most importantly, induction of apoptosis. These results mark cyclin D1 as a target for mantle cell lymphoma and emphasize the therapeutic potential hidden in its silencing.
Laboratory of NanoMedicine, Department of Cell Research and Immunology, George S. Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv, Israel.
Shiri
S
Weinstein
Rafi
R
Emmanuel
Ashley M
AM
Jacobi
Avigdor
A
Abraham
Mark A
MA
Behlke
Andrew G
AG
Sprague
Tatiana I
TI
Novobrantseva
Arnon
A
Nagler
Dan
D
Peer
D000970:Antineoplastic Agents / Q000494:pharmacology; D017209:Apoptosis; D002453:Cell Cycle; D045744:Cell Line, Tumor; D049109:Cell Proliferation; D002470:Cell Survival; D019938:Cyclin D1 / Q000378:metabolism*; D053487:DEAD-box RNA Helicases / Q000378:metabolism; D015972:Gene Expression Regulation, Neoplastic; D020868:Gene Silencing; D006801:Humans; D020522:Lymphoma, Mantle-Cell / Q000628:therapy*; D012313:RNA / Q000378:metabolism; D034622:RNA Interference; D043244:Ribonuclease III / Q000378:metabolism
D000970:Antineoplastic Agents; D019938:Cyclin D1; D012313:RNA; C408087:DICER1 protein, human; D043244:Ribonuclease III; D053487:DEAD-box RNA Helicases