Frequency-specific SSFP for hyperpolarized ¹³C metabolic imaging at 14.1 T.
Metabolic imaging of hyperpolarized [1-(13)C] pyruvate co-polarized with [(13)C]urea by dynamic nuclear polarization with rapid dissolution is a promising new method for assessing tumor metabolism and perfusion simultaneously in vivo. Novel pulse sequences are required to enable dynamic imaging of multiple (13)C spectral lines with high spatiotemporal resolution. The goal of this study was to investigate a new frequency-specific approach for rapid metabolic imaging of multiple (13)C resonances using the spectral selectivity of steady-state free precession pulse (SSFP) trains. Methods developed in simulations were implemented in a dynamic frequency-cycled balanced SSFP pulse sequence on a 14.1-T animal magnetic resonance imaging scanner. This acquisition was tested in thermal and hyperpolarized phantom imaging studies and in a transgenic mouse with prostate cancer.
Department of Radiology and Biomedical Imaging, University of California, San Francisco, CA 94158, USA. cornelius.vonmorze@ucsf.edu
Cornelius
C
von Morze
Subramaniam
S
Sukumar
Galen D
GD
Reed
Peder E Z
PE
Larson
Robert A
RA
Bok
John
J
Kurhanewicz
Daniel B
DB
Vigneron
D000818:Animals; D002247:Carbon Isotopes / Q000494:pharmacology*; D003198:Computer Simulation; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D051379:Mice; D015233:Models, Statistical; D010477:Perfusion; D019047:Phantoms, Imaging; D011471:Prostatic Neoplasms / Q000473:pathology; D019289:Pyruvic Acid / Q000737:chemistry; D013997:Time Factors; D014508:Urea / Q000737:chemistry
D002247:Carbon Isotopes; D019289:Pyruvic Acid; D014508:Urea