Seronegative conversion after incomplete benznidazole treatment in chronic Chagas disease.
In 12-18% of adult patients, treatment with benznidazole for chronic Chagas disease has to be discontinued because of side-effects. We identified and analysed a cohort of 81 adult patients with three positive tests for Trypanosoma cruzi infection and serological monitoring following incomplete treatment with benznidazole for a median of 10 days. Twenty percent of these patients (16/81) met the criteria of cure, showing that the optimal schedule of benznidazole administration remains to be determined.
Sección Chagas, Servicio de Cardiología, Hospital Eva Perón, San Martín, Buenos Aires, Argentina.
M G
MG
Alvarez
C
C
Vigliano
B
B
Lococo
M
M
Petti
G
G
Bertocchi
R
R
Viotti
D000328:Adult; D014355:Chagas Disease / Q000097:blood* / Q000188:drug therapy; D002908:Chronic Disease; D004334:Drug Administration Schedule; D005260:Female; D006801:Humans; D008297:Male; D009593:Nitroimidazoles / Q000008:administration & dosage* / Q000009:adverse effects*; D014344:Trypanocidal Agents / Q000008:administration & dosage* / Q000009:adverse effects*; D014349:Trypanosoma cruzi / Q000187:drug effects*
D009593:Nitroimidazoles; D014344:Trypanocidal Agents; C009999:benzonidazole