Addition of adrenaline to chloroprocaine provides a moderate duration time for epidural anaesthesia in elective caesarean section.
OBJECTIVE
Epidural anaesthesia using chloroprocaine with or without adrenaline and lidocaine with adrenaline were compared.


METHODS
Sixty parturients undergoing elective caesarean section under epidural anaesthesia were randomized to receive 3% chloroprocaine (group C), 3% chloroprocaine  with adrenaline (group CA) or 2% lidocaine with adrenaline (group LA). Onset time, duration time and various maternal, fetal and neonatal parameters were monitored. Pain was assessed using a visual analogue scale.


RESULTS
The onset time of analgesia in group CA was similar to that in group  C but was shorter than that in group LA. Duration of analgesia, loss of cold sensation and motor blockade in group CA were prolonged compared with group C, but were shorter than those in group LA. No differences in maternal, fetal or neonatal effects were seen. A higher pain score was reported  in group C than in groups CA or LA at the end of surgery.


CONCLUSIONS
Epidural anaesthesia using chloroprocaine with adrenaline has a quick onset and moderate duration and is an attractive alternative to lidocaine and adrenaline or chloroprocaine alone for caesarean section.
State Key Laboratory of Reproductive Medicine, Department of Anaesthesiology, Nanjing Maternity and Child Health Care Hospital Affiliated to Nanjing Medical University, 140 Hanzhong Road, Nanjing 210029, China. shanwufeng@163.com
S W
SW
Feng
Y
Y
Cao
W G
WG
Wang
Y S
YS
Liu
X F
XF
Shen
D000767:Anesthesia, Epidural; D000779:Anesthetics, Local / Q000008:administration & dosage*; D001794:Blood Pressure; D002585:Cesarean Section; D017558:Elective Surgical Procedures; D004837:Epinephrine / Q000008:administration & dosage*; D005260:Female; D006339:Heart Rate; D006801:Humans; D011247:Pregnancy; D011343:Procaine / Q000008:administration & dosage / Q000031:analogs & derivatives*
D000779:Anesthetics, Local; D011343:Procaine; C004616:chloroprocaine; D004837:Epinephrine