Repair of the CNS using endogenous and transplanted neural stem cells.
Restoration of the damaged central nervous system is a vast challenge. However, there is a great need for research into this topic, due to the prevalence of central nervous system disorders and the devastating impact they have on people's lives. A number of strategies are being examined to achieve this goal, including cell replacement therapy, enhancement of endogenous plasticity and the recruitment of endogenous neurogenesis. The current chapter reviews this topic within the context of Parkinson's disease, Huntington's disease and stroke. For each disease exogenous cell therapies are discussed including primary (foetal) cell transplants, neural stem cells, induced pluripotent stem cells and marrow stromal cells. This chapter highlights the different mechanistic approaches of cell replacement therapy versus cells that deliver neurotropic factors, or enhance the endogenous production of these factors. Evidence of exogenously transplanted cells functionally integrating into the host brain, replacing cells, and having a behavioural benefit are discussed, along with the ability of some cell sources to stimulate endogenous neuroprotective and restorative events. Alongside exogenous cell therapy, the role of endogenous neurogenesis in each of the three diseases is outlined and methods to enhance this phenomenon are discussed.
School of Biomedical Sciences, University of Nottingham Medical School, Nottingham, NG7 2UH, UK.
R C
RC
Trueman
A
A
Klein
H S
HS
Lindgren
M J
MJ
Lelos
S B
SB
Dunnett
D016026:Bone Marrow Transplantation / Q000379:methods*; D002493:Central Nervous System Diseases / Q000628:therapy*; D006801:Humans; D006816:Huntington Disease / Q000628:therapy; D058953:Neural Stem Cells / Q000637:transplantation*; D055495:Neurogenesis / Q000502:physiology*; D010300:Parkinson Disease / Q000628:therapy; D039904:Pluripotent Stem Cells / Q000637:transplantation*; D033581:Stem Cell Transplantation / Q000379:methods*; D020521:Stroke / Q000628:therapy