One-pot syntheses of novel pyrazole-containing bisphosphonate esters at room temperature.
An efficient general synthetic approach has been developed to synthesize pyrazole-containing bisphosphonate (N-BPs) esters from chromenone derivatives via a sequential two-step reaction in one pot at ambient temperature in good to excellent yields. This protocol provides a new convenient method to prepare lipophilic bisphosphonate precursors with potential activities.
State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zuchongzhi Road, Shanghai, 201203, P. R. China.
Haoyue
H
Xiang
Xueyu
X
Qi
Yuyuan
Y
Xie
Guangyu
G
Xu
Chunhao
C
Yang
D004164:Diphosphonates / Q000138:chemical synthesis* / Q000737:chemistry; D004952:Esters / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D011720:Pyrazoles / Q000737:chemistry*; D013696:Temperature
D004164:Diphosphonates; D004952:Esters; D011720:Pyrazoles; C031280:pyrazole