Antifouling eunicellin-type diterpenoids from the gorgonian Astrogorgia sp.
Twelve new eunicellin-based diterpenoids, astrogorgins B-M (1-12), were isolated from a Chinese gorgonian Astrogorgia sp., together with ophirin, muricellin, astrogorgin, calicophirins A and B, and 14-deacetoxycalicophirin B. The structures of the new compounds were elucidated by extensive spectroscopic analysis and by comparison with data reported in the literature. Significant antifouling activity was observed for 14-deacetoxycalicophirin B against the larval settlement of the barnacle Balanus amphitrite at nontoxic concentrations with an EC(50) = 0.59 μg/mL, while the other analogues were effective within an EC(50) range of 5.14-17.8 μg/mL.
State Key Laboratory of Natural and Biomimetic Drugs, Peking University, Beijing 100191, People's Republic of China.
Daowan
D
Lai
Dong
D
Liu
Zhiwei
Z
Deng
Leen
L
van Ofwegen
Peter
P
Proksch
Wenhan
W
Lin
D000818:Animals; D037421:Anthozoa / Q000737:chemistry*; D057219:Biofouling / Q000517:prevention & control*; D004224:Diterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D007814:Larva / Q000187:drug effects; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D001468:Thoracica / Q000187:drug effects*
D004224:Diterpenes; C476503:eunicellin