The clinical performance of lenses disposed of daily can vary considerably.
OBJECTIVE
To evaluate clinical performance of three lens types disposed of on a daily disposable (DD) basis.


METHODS
A total of 120 participants were randomized into one of three lens types (etafilcon A, narafilcon A, and senofilcon A), all worn bilaterally on a DD regime. Participants were observed at baseline, 2-week, and 1- and 3-month visits where ocular physiology and lens performance variables were collected on a 0 to 4 grading scale in 0.1 increments. Subjective comfort and vision ratings were collected on a 1 to 100 rating scale and in the form of symptom severity.


RESULTS
Forty participants wore each lens type with no differences in age or gender between groups (P>0.05). Etafilcon A exhibited more limbal redness compared with either of the other lens types (P<0.01). More superior corneal staining was noted with narafilcon A lenses compared with senofilcon A (P<0.01), and more superior conjunctival indentation was noted for narafilcon A compared with etafilcon A (P=0.001). No differences were found between lenses in the 1 to 100 rating scale (P>0.05). Narafilcon A showed more moderate to severe dryness symptoms and symptoms of blurred vision at lens wearing visits (P<0.05). One bilateral contact lens papillary conjunctivitis, one unilateral superior epithelial arcuate lesion, and one infiltrative keratitis were associated with narafilcon A only. Of the seven discontinuations, six were from the narafilcon A group.


CONCLUSIONS
Different contact lens materials and designs, worn on the same DD modality, elicit different ocular and patient responses. Narafilcon A did not perform clinically as well as etafilcon A and senofilcon A worn on a DD modality.
Brien Holden Vision Institute, Sydney, Australia. j.diec@brienholdenvision.org
Jennie
J
Diec
Percy
P
Lazon de la Jara
Mark
M
Willcox
Brien A
BA
Holden
D000328:Adult; D003263:Contact Lenses, Hydrophilic / Q000009:adverse effects / Q000592:standards*; D003315:Cornea / Q000502:physiology; D004209:Disposable Equipment; D005260:Female; D006801:Humans; D016015:Logistic Models; D008297:Male; D009216:Myopia / Q000503:physiopathology / Q000534:rehabilitation*; D017060:Patient Satisfaction; D011446:Prospective Studies; D012720:Severity of Illness Index; D014785:Vision, Ocular / Q000502:physiology