Identification of the novel HLA-B*13:02:13 allele in a Taiwanese haematopoietic stem cell donor and the probable HLA haplotype in association with B*13:02:13.
Using sequence-based typing method, we found a new HLA-B*13:02 variant, B*13:02:13, in a Taiwanese haematopoietic stem cell donor. The DNA sequence of B*13:02:13 is identical to the sequence of B*13:02:01 in exons 2 and 3 except the nucleotide at position 588 where G is replaced by T (codon 172; CTG→CTT). The DNA sequence variation did not alter the amino acid sequence of B*13:02:01. The generation of B*13:02:13 is thought to derive from B*13:02:01 as a result of a silence mutation. The probable HLA-A, HLA-B and HLA-DRB1 haplotype in association with B*13:02:1 may be deduced as HLA-A*24-B*13:02:13-DRB1*07:01 or HLA-A*02-B*13:02:13-DRB1*07:01. The discovery of B*13:02:13 furthers the polymorphism of HLA-B*13 and HLA-B*13:02.
Laboratory of Immunogenetics and Cord Blood Bank, Buddhist Tzu Chi Stem Cells Centre and Marrow Donor Registry, Buddhist Tzu Chi General Hospital, Buddhist Compassion Relief Tzu Chi Foundation, Hualien, Taiwan. edward@tzuchi.com.tw
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Yang
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Lee
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D000483:Alleles; D044466:Asian People / Q000235:genetics*; D005787:Gene Frequency; D014644:Genetic Variation; D015235:HLA-B Antigens / Q000235:genetics*; D006239:Haplotypes; D006412:Hematopoietic Stem Cells / Q000378:metabolism*; D006801:Humans; D012042:Registries; D013624:Taiwan; D014019:Tissue Donors
D015235:HLA-B Antigens