[Clinical study of tissue expression and serum contents of VEGF-C in cervical diseases of Uighur women].
OBJECTIVE
To detect the VEGF-C expression in the serum and tissue of cervical diseases. To explore correlation of tissue and serum expression and the clinical significance of VEGF-C in the cervical intraepithelial neoplasia and cervical squamous-celled carcinoma of Uighur momen in Xinjiang.


METHODS
(1) The VEGF- C expressions in tissue were tested by immunohistochemisty from the 22 chronic cervicitis, 24 CIN,and 43 squamous-celled carcinoma patients, (2) The VEGF-C contents in the serum were tested by enzyme-linked immunosorbent assay (ELISA) from the 15 chronic cervicitis, 23 CIN, and 40 squamous-celled carcinoma patients.


RESULTS
(1) The expression of VEGF-C in the tissue of cervicitis, CIN and cervical carcinoma were separately 9.1%, 87.50%, 100%, the differences had significance (P < 0.05). (2) The VEGF-C serum contents were gradually increased from cervicitis to CIN and cervical carcinoma, the differences had significance (P < 0.05). (3) The compartment of results of VEGF-C in serum and tissue showed that, there were correlation between to of them, the more tissue expressions, the more serum expressions will be (r = 0.27, F = 5.327, P < 0.05).


CONCLUSIONS
VEGF-C has played an facilitation rule in the transition process of CIN to cervical squamous cell carcinoma of the Uygure women in Xinjiang, there are correlation of VEGF-C expression between tissue and serum.
Department of Gynecology Tumor Hospital affilated Xinjiang Medical University, 830011 Urumqi, China.
Xin-Ling
XL
Wang
Yuan-Yuan
YY
Zhang
Zhalinuer-Abulizi
ZA
Gu
Ming-Yue
MY
Zhu
D002294:Carcinoma, Squamous Cell / Q000378:metabolism*; D002681:China / Q000208:ethnology; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D002583:Uterine Cervical Neoplasms / Q000378:metabolism*; D042582:Vascular Endothelial Growth Factor C / Q000032:analysis* / Q000097:blood / Q000502:physiology; D002578:Uterine Cervical Dysplasia / Q000378:metabolism*
D042582:Vascular Endothelial Growth Factor C