Dendritic cells as natural adjuvants and modulators of immune response in cancer immunotherapy.
Dendritic cells (DCs) are potent antigen presenting cells. Mature DCs activate antigen specific naïve T cells, B cells and NK cells. Under certain conditions, DCs even silence T cell immune responses in vivo, thus, modulating the immune response. This special function of DCs could be exploited in the treatment of cancer, autoimmune disorder and chronic viral infections.
Centre for Cellular & Molecular Biology, Uppal Road, Hyderabad 500 007, India.
Rajshekhar S
RS
Alli
Ashok
A
Khar
D000276:Adjuvants, Immunologic / Q000627:therapeutic use; D000938:Antigen-Presenting Cells / Q000166:cytology; D001402:B-Lymphocytes / Q000276:immunology; D019496:Cancer Vaccines; D019070:Cell Lineage; D003713:Dendritic Cells / Q000166:cytology* / Q000276:immunology; D020868:Gene Silencing; D006801:Humans; D007107:Immune System / Q000502:physiology*; D007167:Immunotherapy / Q000379:methods*; D007694:Killer Cells, Natural / Q000166:cytology; D016131:Lymphocyte Subsets / Q000166:cytology; D008954:Models, Biological; D009369:Neoplasms / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology
D000276:Adjuvants, Immunologic; D019496:Cancer Vaccines