A general requirement for FcγRIIB co-engagement of agonistic anti-TNFR antibodies.
Comment on: Li F, et al. Proc Natl Acad Sci USA 2012; 109:10966-71.
Fubin
F
Li
Jeffrey V
JV
Ravetch
D000818:Animals; D000906:Antibodies / Q000276:immunology* / Q000494:pharmacology*; D006801:Humans; D051379:Mice; D009154:Mutation / Q000235:genetics; D015202:Protein Engineering; D051381:Rats; D017452:Receptors, IgG / Q000235:genetics / Q000276:immunology*; D018124:Receptors, Tumor Necrosis Factor / Q000819:agonists* / Q000276:immunology*; D015398:Signal Transduction / Q000187:drug effects
D000906:Antibodies; C080571:Fc gamma receptor IIB; D017452:Receptors, IgG; D018124:Receptors, Tumor Necrosis Factor