Triplex-directed covalent cross-linking of a DNA nanostructure.
The triplex approach to DNA recognition is exploited to direct covalent inter-strand cross-links to unique locations within a pre-assembled DNA nanostructure. This approach can be used to improve the stability of DNA nanostructures and demonstrates the feasibility of directing other reactive groups to unique locations within these complexes.
Centre for Biological Sciences, University of Southampton, Highfield, Southampton, UK. D.A.Rusling@soton.ac.uk
David A
DA
Rusling
Iris S
IS
Nandhakumar
Tom
T
Brown
Keith R
KR
Fox
D001483:Base Sequence; D003432:Cross-Linking Reagents / Q000737:chemistry*; D004247:DNA / Q000737:chemistry*; D008969:Molecular Sequence Data; D049329:Nanostructures / Q000737:chemistry*
D003432:Cross-Linking Reagents; D004247:DNA