3,3'-Diiodothyronine sulfate cross-reactive material (compound W) in human newborns.
BACKGROUND
Thyrosulfoconjugation appears to facilitate fetal-to-maternal transfer of 3,3'-diiodothyronine-sulfate (T(2)S). Elevated maternal levels of T(2)S cross-reactive material (compound W) are found in humans, with higher levels found in venous cord blood than in arterial samples. These findings are consistent with the postulate that the placenta plays an essential role in compound W production.


METHODS
Serum compound W levels were measured by a T(2)S-specific radioimmunoassay in 60 serum samples from newborns with hyperbilirubinemia, age 1-30 d. In addition, 59 maternal serum samples, from day 1 to day 7 after uneventful deliveries, were studied.


RESULTS
As compared with day 1, at day 5, the mean (±SE) compound W level fell to 43.5 ± 6.8% (decay half-life (t(1/2)) = 4.12 d) and to 33.7 ± 4.6% (decay t(1/2) = 2.82 d) in the newborn and maternal groups, respectively. In the mothers, the level continued to decline along the same slope through day 7. In the newborns, however, the mean compound W level entered a slower phase of decay after the fifth day with a decay t(1/2) = 10.9 d.


CONCLUSIONS
Compound W is cleared at similar rates in newborn and postpartum maternal sera. This is consistent with the postulate that compound W is produced in the placenta.
Laboratory Department, Wuxi Hospital for Maternal and Child Health Care, Wuxi, China.
Daozhen
D
Chen
Huixin
H
Yu
Jiandong
J
Bao
Wenqun
W
Xue
Yuan
Y
Xing
Li
L
Zhang
William L
WL
Green
Delbert A
DA
Fisher
Sing-Yung
SY
Wu
D000704:Analysis of Variance; D000906:Antibodies; D015415:Biomarkers / Q000097:blood; D003429:Cross Reactions; D004104:Diiodothyronines / Q000097:blood* / Q000276:immunology; D005260:Female; D006207:Half-Life; D006801:Humans; D006932:Hyperbilirubinemia / Q000097:blood*; D007231:Infant, Newborn; D016014:Linear Models; D008297:Male; D010920:Placenta / Q000378:metabolism; D049590:Postpartum Period / Q000097:blood; D011247:Pregnancy; D011863:Radioimmunoassay; D013997:Time Factors
D000906:Antibodies; D015415:Biomarkers; D004104:Diiodothyronines; C404304:compound W; C045738:3,3'-diiodothyronine-4-sulfate