Substituent-dependent fluorescent sensors for zinc ions based on carboxamidoquinoline.
A series of carboxamidoquinoline-based fluorescent sensors (the AQZ family) were synthesized and characterized. The AQZ family members were highly soluble in water and showed good selectivity for Zn(2+)via enhanced fluorescence in aqueous buffer solution. Fluorescence signals could be tuned from dual-wavelength ratiometric changes to changes in the intensity of a single wavelength upon binding Zn(2+) through the introduction of different substituents onto the quinoline ring. Concentrations of free Zn(2+) of 10(-5)-10(-6) M could be detected using the sensors. Changes of substituents and their positions on the quinoline ring influenced the sensitivity for Zn(2+), but had little effect on Zn(2+) affinities.
College of Heilongjiang Province Key Laboratory of Fine Chemicals, Qiqihar University, Qiqihar, 161006, China.
Yu
Y
Zhang
Xiangfeng
X
Guo
Lihua
L
Jia
Shicheng
S
Xu
Zhihui
Z
Xu
Libo
L
Zheng
Xuhong
X
Qian
D005456:Fluorescent Dyes / Q000737:chemistry*; D007477:Ions / Q000737:chemistry; D008856:Microscopy, Fluorescence; D011804:Quinolines / Q000737:chemistry*; D012441:Saccharomyces cerevisiae / Q000166:cytology; D013050:Spectrometry, Fluorescence; D014867:Water / Q000737:chemistry; D015032:Zinc / Q000737:chemistry*
D005456:Fluorescent Dyes; D007477:Ions; D011804:Quinolines; D014867:Water; C037219:quinoline; D015032:Zinc