Strategies for personalized medicine-based research and implementation in the clinical workflow.
The decoding of the human genome, paralleled by the development of high-throughput technologies to obtain large-scale molecular data (e.g., information on genetic variations, transcription levels, and metabolite concentrations) is providing new insights into the molecular basis of common diseases and the causes of variability in drug response. This article presents strategies to incorporate this new knowledge into research and clinical workflow.
University Medicine Greifswald, Institute for Community Medicine, Greifswald, Germany.
W
W
Lieb
H
H
Völzke
J M
JM
Pulley
D M
DM
Roden
H K
HK
Kroemer
D035843:Biomedical Research / Q000379:methods; D006801:Humans; D010597:Pharmacogenetics / Q000379:methods; D057285:Precision Medicine / Q000379:methods*; D057170:Translational Research, Biomedical / Q000379:methods*; D057188:Workflow