Flash generation of a highly reactive Pd catalyst for Suzuki-Miyaura coupling by using a flow microreactor.
Superflash! Flash chemistry enables the use of highly reactive unstable species as catalysts for chemical synthesis. Fast micromixing of a solution of [Pd(OAc)(2)] and that of tBu(3) P in 1:1 mole ratio gave a solution of a highly reactive unstable species, which was immediately transferred to a vessel by using a flow microreactor, in which Suzuki-Miyaura coupling was conducted (see scheme).
Department of Synthetic and Biological Chemistry, Graduate School of Engineering, Kyoto University Nishikyo-ku, Kyoto, 615-8510, Japan.
Aiichiro
A
Nagaki
Naofumi
N
Takabayashi
Yuya
Y
Moriwaki
Jun-ichi
J
Yoshida