Netrin-1 concentrations in patients with advanced gastric cancer and its relation with treatment.
BACKGROUND
Netrin-1 is found to be elevated and usable as a diagnostic biomarker in many human cancers.


OBJECTIVE
We evaluated serum Netrin-1 concentrations in patients with advanced gastric cancer compared with those in a healthy group.


METHODS
Thirty patients with advanced gastric cancer and thirty healthy people were included in the study. Serum netrin-1 concentrations were measured by quantitative ELISA method in both groups.


RESULTS
The mean serum Netrin-1 concentrations were found to be significantly higher in patients with gastric cancer than in healthy controls. The mean serum Netrin-1 concentrations were found to be significantly higher in patients with gastric cancer before the beginning of chemotherapy when compared after the completion of third cycle.


CONCLUSIONS
Our results indicated that netrin-1 concentrations elevated in advanced gastric cancer compared to a healthy control group and netrin-1 concentrations decreased with chemotherapy.
Department of Medical Oncology, Dr. Lutfi Kirdar Kartal Education and Research Hospital, Istanbul, Turkey. ukefeli@yahoo.com
Umut
U
Kefeli
Mahmut Emre
ME
Yildirim
Dincer
D
Aydin
Ozlem Cakir
OC
Madenci
Nurgul
N
Yasar
Nur
N
Sener
Aslihan Guven
AG
Mert
Sinemis
S
Yuksel
Ozlem Balvan
OB
Ercelep
Taner
T
Korkmaz
Ramazan
R
Yildiz
Mahmut
M
Gumus
D000230:Adenocarcinoma / Q000097:blood* / Q000188:drug therapy / Q000401:mortality / Q000556:secondary; D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000097:blood*; D018572:Disease-Free Survival; D005260:Female; D006801:Humans; D008113:Liver Neoplasms / Q000097:blood* / Q000188:drug therapy / Q000401:mortality / Q000556:secondary; D008297:Male; D008875:Middle Aged; D009414:Nerve Growth Factors / Q000097:blood*; D000075388:Netrin-1; D013274:Stomach Neoplasms / Q000097:blood* / Q000188:drug therapy / Q000401:mortality / Q000473:pathology; D016019:Survival Analysis; D025521:Tumor Suppressor Proteins / Q000097:blood*
D014408:Biomarkers, Tumor; C000617351:NTN1 protein, human; D009414:Nerve Growth Factors; D025521:Tumor Suppressor Proteins; D000075388:Netrin-1