Comparison of destructive periodontal disease in blue iris mink to PCB 126-induced mandibular and maxillary squamous epithelial proliferation in natural dark mink.
Mink (Mustela vison) exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-like chemicals have been reported to develop mandibular and maxillary squamous cell proliferation that results in the destruction of alveolar bone and eventual tooth loss. This jaw lesion has been reported in wild mink collected from areas contaminated with TCDD-like compounds and is a potential biomarker for exposure to these chemicals. The blue iris strain of domestic mink is prone to develop severe periodontal disease, which results in destruction of bone and tooth loss that is grossly similar to the lesion induced by exposure to TCDD-like chemicals. A histological assessment of jaws from blue iris mink and natural dark mink exposed to 3,3',4,4',5-pentachlorobiphenyl (PCB 126) was done to determine whether the oral lesions are similar. The jaw tissue from the blue iris mink had lesions indicative of lymphoplasmacytic gingivitis and osteomyelitis, caused by inflammation entering the dental sulcus, while the jaw tissue from the mink exposed to PCB 126 exhibited squamous epithelial proliferation. Therefore, it was determined that the tooth loss and bone destruction seen in these mink are of different origin despite the similarity of the gross clinical signs.
Department of Animal Science, Michigan State University, East Lansing, MI 48824, USA.
Rachel M
RM
Ellick
Scott D
SD
Fitzgerald
Jane E
JE
Link
Steven J
SJ
Bursian
D000818:Animals; D000829:Animals, Domestic; D000835:Animals, Wild; D004785:Environmental Pollutants / Q000633:toxicity*; D005260:Female; D006651:Histocytochemistry; D008336:Mandibular Diseases / Q000139:chemically induced / Q000473:pathology / Q000662:veterinary*; D008439:Maxillary Diseases / Q000139:chemically induced / Q000473:pathology / Q000662:veterinary*; D008907:Mink; D009055:Mouth / Q000473:pathology; D010510:Periodontal Diseases / Q000473:pathology / Q000662:veterinary*; D011078:Polychlorinated Biphenyls / Q000633:toxicity*
D004785:Environmental Pollutants; D011078:Polychlorinated Biphenyls; C023035:3,4,5,3',4'-pentachlorobiphenyl