Asymmetric synthesis of trifluoromethylated amines via catalytic enantioselective isomerization of imines.
A new approach toward the asymmetric synthesis of optically active trifluoromethylated amines was enabled by an unprecedented, highly enantioselective catalytic isomerization of trifluoromethyl imines with a new chiral organic catalyst. Not only aryl but also alkyl trifluoromethylated amines could be obtained in high enantioselectivities.
Department of Chemistry, Brandeis University, Waltham, Massachusetts 02454-9110, USA.
Yongwei
Y
Wu
Li
L
Deng
D000588:Amines / Q000138:chemical synthesis* / Q000737:chemistry*; D002384:Catalysis; D060326:Chemistry Techniques, Synthetic; D005617:Chlorofluorocarbons, Methane / Q000737:chemistry*; D007097:Imines / Q000737:chemistry*; D013237:Stereoisomerism; D013379:Substrate Specificity
D000588:Amines; D005617:Chlorofluorocarbons, Methane; D007097:Imines; C009554:fluoroform