Genome wide assessment of young onset Parkinson's disease from Finland.
In the current study we undertook a series of experiments to test the hypothesis that a monogenic cause of disease may be detectable within a cohort of Finnish young onset Parkinson's disease patients. In the first instance we performed standard genome wide association analyses, and subsequent risk profile analysis. In addition we performed a series of analyses that involved testing measures of global relatedness within the cases compared to controls, searching for excess homozygosity in the cases, and examining the cases for signs of excess local genomic relatedness using a sliding window approach. This work suggested that the previously identified common, low risk alleles, and the risk models associated with these alleles, were generalizable to the Finnish Parkinson's disease population. However, we found no evidence that would suggest a single common high penetrance mutation exists in this cohort of young onset patients.
Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, Maryland, United States of America.
Dena G
DG
Hernandez
Michael A
MA
Nalls
Pauli
P
Ylikotila
Margaux
M
Keller
John A
JA
Hardy
Kari
K
Majamaa
Andrew B
AB
Singleton
D017668:Age of Onset; D000368:Aged; D016022:Case-Control Studies; D005387:Finland / Q000453:epidemiology; D056426:Genetic Loci / Q000235:genetics; D020022:Genetic Predisposition to Disease; D055106:Genome-Wide Association Study; D006801:Humans; D008875:Middle Aged; D010300:Parkinson Disease / Q000453:epidemiology* / Q000235:genetics*; D012307:Risk Factors; D044465:White People / Q000235:genetics