Emerging role of interleukin-22 in autoimmune diseases.
Interleukin-22 (IL-22) is an IL-10 family cytokine member that was recently discovered to be mainly produced by Th17 cells. Previous studies have indicated the importance of IL-22 in host defense against Gram-negative bacterial organisms (in gut and lung). Recently, there is emerging evidence that IL-22 is involved in the development and pathogenesis of several autoimmune diseases, such as systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), multiple sclerosis (MS), Sjögren's syndrome (SS) and psoriasis. Therapeutics targeting IL-22 therefore may have promise for treating various autoimmune diseases. In this review, we discuss the recent progression of the involvement of IL-22 in the development and pathogenesis of autoimmune diseases, as well as its clinical implications and therapeutic potential.
Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, Hefei, China.
Hai-Feng
HF
Pan
Xiang-Pei
XP
Li
Song Guo
SG
Zheng
Dong-Qing
DQ
Ye
D000818:Animals; D001172:Arthritis, Rheumatoid / Q000276:immunology; D001327:Autoimmune Diseases / Q000276:immunology*; D006801:Humans; D007378:Interleukins / Q000502:physiology*; D008180:Lupus Erythematosus, Systemic / Q000276:immunology; D009103:Multiple Sclerosis / Q000276:immunology; D011565:Psoriasis / Q000276:immunology; D015398:Signal Transduction; D012859:Sjogren's Syndrome / Q000276:immunology; D058504:Th17 Cells / Q000276:immunology / Q000378:metabolism; D000097043:Interleukin-22
D007378:Interleukins; D000097043:Interleukin-22