[A new principle in the selection of vaccinal rabies virus based on quantitation of the expression of G protein, a major immunogen of rabies virus].
The paper describes a new principle of the selection of the rabies virus vaccine strain ERA-CB20M based on quantitation of the expression of glycoprotein, a major immunogen of rabies virus. There is a correlation between the level of glycoprotein expression and that of vaccine virus attenuation. The application of the new principle for vaccine virus selection will permit a safer and more immunogenic rabies vaccine to be prepared.
S V
SV
Gribencha
M A
MA
Losich
L F
LF
Gribencha
I V
IV
Nepoklonova
D000818:Animals; D002417:Cattle; D015967:Gene Expression Regulation, Viral / Q000276:immunology; D006023:Glycoproteins / Q000276:immunology* / Q000378:metabolism; D006801:Humans; D051379:Mice; D011818:Rabies / Q000517:prevention & control / Q000821:virology; D011819:Rabies Vaccines / Q000235:genetics / Q000276:immunology / Q000378:metabolism; D011820:Rabies virus / Q000276:immunology / Q000378:metabolism / Q000472:pathogenicity; D051381:Rats
D006023:Glycoproteins; D011819:Rabies Vaccines