Pharmacologic reduction of angiographic vasospasm in experimental subarachnoid hemorrhage: systematic review.
Animal models have been developed to simulate angiographic vasospasm secondary to subarachnoid hemorrhage (SAH) and to test pharmacologic treatments. Our aim was to evaluate the effect of pharmacologic treatments that have been tested in humans and in preclinical studies to determine if animal models inform results reported in humans. A systematic review and meta-analysis of SAH studies was performed. We investigated predictors of -translation from animals to humans with multivariate logistic regression. Pharmacologic reduction of vasospasm was effective in mice, rats, rabbits, dogs, nonhuman primates, and humans. Animal studies were generally of poor methodologic quality, and there was evidence of publication bias. Fresh blood injection to simulate SAH (vs. clot placement) and evaluation of vasospasm more than 3 days after SAH were independently associated with successful translation. We conclude that reduction of vasospasm is effective in animals and humans, and that injection of fresh blood and evaluation of vasospasm more than 3 days after SAH may be preferable for preclinical models.
Department of Anesthesia and Critical Care Medicine, University of Milano, Milan, Italy.
Tommaso
T
Zoerle
Don
D
Ilodigwe
Hoyee
H
Wan
Katarina
K
Lakovic
Mohammed
M
Sabri
Jinglu
J
Ai
R Loch
RL
Macdonald
D000818:Animals; D002533:Cerebral Angiography; D004195:Disease Models, Animal; D006801:Humans; D039781:PubMed / Q000706:statistics & numerical data; D013345:Subarachnoid Hemorrhage / Q000150:complications*; D014661:Vasoconstriction / Q000187:drug effects; D014665:Vasodilator Agents / Q000494:pharmacology / Q000627:therapeutic use*; D020301:Vasospasm, Intracranial / Q000188:drug therapy* / Q000209:etiology*
D014665:Vasodilator Agents