Primary central nervous system angiosarcoma: two case reports.
BACKGROUND
Primary angiosarcoma of the brain is extremely rare; only 15 cases have been reported in adults over the last 25 years.


METHODS
We describe two cases of primary angiosarcoma of the brain that are well characterized by imaging, histopathology, and immunohistochemistry. Case 1: our first patient was a 35-year-old woman who developed exophthalmos. Subtotal resection of a left extra-axial retro-orbital mass was performed. Case 2: our second patient was a 47-year-old man who presented to our facility with acute visual loss, word-finding difficulty and subtle memory loss. A heterogeneously-enhancing left sphenoid wing mass was removed. We also review the literature aiming at developing a rational approach to diagnosis and treatment, given the rarity of this entity.


CONCLUSIONS
Gross total resection is the standard of care for primary angiosarcoma of the brain. Adjuvant radiation and chemotherapy are playing increasingly recognized roles in the therapy of these rare tumors.
Division of Neuropathology, University of Alabama at Birmingham, PD6A 175, Birmingham, AL, 35294, USA. capalmer@uab.edu.
James R
JR
Hackney
Cheryl Ann
CA
Palmer
Kristen O
KO
Riley
Joel K
JK
Cure
Hassan M
HM
Fathallah-Shaykh
Louis B
LB
Nabors