Amlodipine affects endogenous hydrogen sulfide tissue concentrations in different mouse organs.
The interactions between calcium channel blockers' action and the endogenous hydrogen sulfide (H2S) biology are unknown. CBA strain mice were administered intraperitoneally 3 mg/kg b.w. per day or 10 mg/kg b.w. per day of amlodipine. The control group received physiological saline. The measurements of the free H2S tissue concentrations were performed with Siegel spectrophotometric modified method. There was as significant fall of H2S level in the brain and the liver in both groups. The lower amlodipine dose increased the H2S concentrations in the heart and kidneys while the higher one decreased H2S accumulation in those organs. Our experiment has shown that amlodipine interferes with H2S biology and affects its tissue concentrations in different mouse tissues.
Zakład Biologii Rozwoju Człowieka, Wydział Nauk o Zdrowiu, Uniwersytet Jagielloński Collegium Medicum, Kraków, Poland. bowil@interia.pl
Bogdan
B
Wiliński
Jerzy
J
Wiliński
Eugeniusz
E
Somogyi
Joanna
J
Piotrowska
Marta
M
Góralska
D017311:Amlodipine / Q000494:pharmacology*; D000818:Animals; D001921:Brain / Q000378:metabolism*; D002121:Calcium Channel Blockers / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D005260:Female; D006862:Hydrogen Sulfide / Q000378:metabolism*; D007274:Injections, Intraperitoneal; D007668:Kidney / Q000378:metabolism*; D008099:Liver / Q000378:metabolism*; D051379:Mice; D008808:Mice, Inbred CBA; D009206:Myocardium / Q000378:metabolism*
D002121:Calcium Channel Blockers; D017311:Amlodipine; D006862:Hydrogen Sulfide