Isoprenaline and quinidine to calm Brugada VF storm.
A 3-year-old man with an implanted cardioverter-defibrillator (ICD) for type 2 Brugada syndrome was admitted to coronary care unit with ventricular fibrillation electrical storm and consequent appropriate recurrent ICD shocks. The rhythm did not settle with conventional antiarrhythmics such as β-blockers and amiodarone. An isoprenaline infusion was set up with immediate stabilisation of rhythm. After a period of monitoring, the infusion was stopped and oral quinidine was started. He has remained free of problems for 1 year. This case-report summarises these novel treatments for electrical storm in Brugada syndrome and the mechanism behind them.
Cardiology Department, Torbay General Hospital, Torquay, UK. guyfurniss@yahoo.co.uk
Guy
G
Furniss
D000318:Adrenergic beta-Agonists / Q000627:therapeutic use*; D000328:Adult; D000889:Anti-Arrhythmia Agents / Q000627:therapeutic use*; D053840:Brugada Syndrome / Q000150:complications*; D006801:Humans; D007545:Isoproterenol / Q000627:therapeutic use*; D008297:Male; D011802:Quinidine / Q000627:therapeutic use*; D014693:Ventricular Fibrillation / Q000188:drug therapy* / Q000209:etiology
D000318:Adrenergic beta-Agonists; D000889:Anti-Arrhythmia Agents; D011802:Quinidine; D007545:Isoproterenol