Experimental first-pass method for testing and comparing sorbent polymers used in the clearance of iodine contrast materials.
BACKGROUND
Sorbents have been shown to adsorb iodinated radiocontrast media.


OBJECTIVE
In this study we describe a simple method to compare various sorbents in terms of capacity to adsorb radiocontrast media.


METHODS
Iodixanol solution was injected into columns filled with three types of sorbent at filtration velocities of increasing magnitude. Two variables of interest - contrast removal rate and matched iodine retention (MIR) - were calculated to measure the adsorption efficiency and the mass of contrast iodine adsorbed versus sorbent used, respectively.


RESULTS
The highest contrast removal and MIR for Porapak Q, CST 401 and Amberlite XAD4 were 41, 38 and 16% (p = 0.22 and 0.0005 for comparisons between Porapak Q-CST 401 and CST 401-Amberlite XAD4) and 0.060, 0.055 and 0.024, respectively (p = 0.18 and 0.0008). Extrapolation to a clinical scenario may suggest that removal of 8 ml iodixanol could be achieved by masses of sorbents of 43, 47 and 107 g, respectively.


CONCLUSIONS
In this study we set a benchmark for comparing the radiocontrast-adsorbing efficiency of polymer sorbents during first-pass experiments, using a readily available methodology.
Heart and Vascular Institute, University of Pittsburgh Medical Center, Pittsburgh, PA, USA. goangheloiu@drmc.org
George O
GO
Angheloiu
Heribert
H
Hänscheid
Xiaoyan
X
Wen
Vincent
V
Capponi
William D
WD
Anderson
John A
JA
Kellum
D000327:Adsorption; D003287:Contrast Media / Q000737:chemistry*; D006801:Humans; D007455:Iodine / Q000737:chemistry*; D007700:Kinetics; D011108:Polymers / Q000737:chemistry*; D014283:Triiodobenzoic Acids / Q000737:chemistry
D003287:Contrast Media; D011108:Polymers; D014283:Triiodobenzoic Acids; D007455:Iodine; C044834:iodixanol