Changing epidemiology of extended-spectrum β-lactamases in Argentina: emergence of CTX-M-15.
A multicenter survey, carried out in 2010 in Argentina, showed an increased prevalence of extended-spectrum β-lactamase (ESBL)-producing enterobacteria, with some changes in the molecular epidemiology of circulating ESBLs. While enzymes of the CTX-M-2 group remain endemic, the emergence of CTX-M-15 and of enzymes of the CTX-M-8 and CTX-M-9 groups was observed. The CTX-M-15-positive isolates represented 40% of CTX-M producers and included representatives of Escherichia coli ST131 and Klebsiella pneumoniae ST11.
Dipartimento di Biotecnologie, Sezione di Microbiologia, Università di Siena, Siena, Italy.
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S
Sennati
G
G
Santella
J
J
Di Conza
L
L
Pallecchi
M
M
Pino
B
B
Ghiglione
G M
GM
Rossolini
M
M
Radice
G
G
Gutkind
D000900:Anti-Bacterial Agents / Q000494:pharmacology / Q000627:therapeutic use; D001118:Argentina / Q000453:epidemiology; D004926:Escherichia coli / Q000187:drug effects* / Q000235:genetics; D004927:Escherichia coli Infections / Q000188:drug therapy* / Q000453:epidemiology / Q000382:microbiology; D018740:Genetic Heterogeneity; D006801:Humans; D007710:Klebsiella Infections / Q000188:drug therapy* / Q000453:epidemiology / Q000382:microbiology; D007711:Klebsiella pneumoniae / Q000187:drug effects* / Q000235:genetics; D018440:beta-Lactam Resistance / Q000187:drug effects / Q000235:genetics*; D001618:beta-Lactamases / Q000235:genetics* / Q000378:metabolism; D047090:beta-Lactams / Q000494:pharmacology / Q000627:therapeutic use
D000900:Anti-Bacterial Agents; D047090:beta-Lactams; C071167:beta-lactamase CTX-2; C473109:beta-lactamase CTX-M-15; D001618:beta-Lactamases