Oxidative burden and antioxidant defense system in polymorphonuclear leukocytes of human lung diseases.
Superoxide anion (O2.-) and hydrogen peroxide (H2O2) production was significantly higher in blood neutrophils (PMNs) of patients with lung cancer and non-malignant lung diseases when compared to the controls (p<0.001). Superoxide dismutase (SOD) activity was significantly decreased in PMNs of patients with lung cancer (p<0.001). Similarly, catalase and glutathione peroxidase (GPx) activities were lower in PMNs of lung cancer patients as compared to non-malignant lung diseases and controls. There was an increase in HMP shunt activity as measured by rate of formation of 14CO2 from [1-14C]-glucose in PMNs of lung cancer patients. Modifications in the antioxidant defense system in PMNs of malignant and nonmalignant lung diseases, the changes being more in the malignancy are indicated.
Department of Biophysics, Postgraduate Institute of Medical Education & Research, Chandigarh 160 012, India.
Rashmi N
RN
Sharma
A
A
Bhardwaj
D
D
Behera
K L
KL
Khanduja
D000368:Aged; D000975:Antioxidants / Q000737:chemistry / Q000494:pharmacology*; D005260:Female; D006601:Hexoses / Q000737:chemistry; D006801:Humans; D006861:Hydrogen Peroxide / Q000737:chemistry; D008171:Lung Diseases / Q000097:blood / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D009504:Neutrophils / Q000378:metabolism*; D018384:Oxidative Stress; D010100:Oxygen / Q000378:metabolism*; D010710:Phosphates / Q000737:chemistry; D012907:Smoking / Q000009:adverse effects; D013481:Superoxides / Q000737:chemistry; D014018:Tissue Distribution
D000975:Antioxidants; D006601:Hexoses; D010710:Phosphates; D013481:Superoxides; D006861:Hydrogen Peroxide; D010100:Oxygen