Overview of plant-made vaccine antigens against malaria.
This paper is an overview of vaccine antigens against malaria produced in plants. Plant-based expression systems represent an interesting production platform due to their reduced manufacturing costs and high scalability. At present, different Plasmodium antigens and expression strategies have been optimized in plants. Furthermore, malaria antigens are one of the few examples of eukaryotic proteins with vaccine value expressed in plants, making plant-derived malaria antigens an interesting model to analyze. Up to now, malaria antigen expression in plants has allowed the complete synthesis of these vaccine antigens, which have been able to induce an active immune response in mice. Therefore, plant production platforms offer wonderful prospects for improving the access to malaria vaccines.
Laboratorio de Biotecnología Vegetal, Instituto Investigaciones Biotecnológicas-Instituto Tecnológico Chascomús, Camino de Circunvalación km 8.2, 7130 Buenos Aires, Argentina. mclemente@intech.gov.ar
Marina
M
Clemente
Mariana G
MG
Corigliano
D000818:Animals; D052179:Antigens, Plant / Q000276:immunology*; D006801:Humans; D008018:Life Cycle Stages; D008288:Malaria / Q000276:immunology* / Q000517:prevention & control*; D017780:Malaria Vaccines / Q000276:immunology*; D010944:Plants / Q000378:metabolism*; D010961:Plasmodium / Q000254:growth & development / Q000276:immunology*
D052179:Antigens, Plant; D017780:Malaria Vaccines