Organocatalytic deprotonative functionalization of C(sp2)-H and C(sp3)-H bonds using in situ generated onium amide bases.
Onium amides, generated in situ from the combination of aminosilanes and onium fluorides (R(4)PF, R(4)NF), are employed for the first time as bases for catalytic deprotonative functionalization of C(sp(2))-H and activated C(sp(3))-H bonds under mild conditions.
Graduate School of Pharmaceutical Sciences, Tohoku University, 6-3, Aoba, Aramaki, Aoba-ku, Sendai 980-8578, Japan. inamoto@m.tohoku.ac.jp
Kiyofumi
K
Inamoto
Hitomi
H
Okawa
Hiroshi
H
Taneda
Maomi
M
Sato
Yutaro
Y
Hirono
Misato
M
Yonemoto
Shoko
S
Kikkawa
Yoshinori
Y
Kondo
D000577:Amides / Q000138:chemical synthesis / Q000737:chemistry*; D002384:Catalysis; D006860:Hydrogen Bonding; D015394:Molecular Structure; D009861:Onium Compounds / Q000138:chemical synthesis / Q000737:chemistry*; D011522:Protons
D000577:Amides; D009861:Onium Compounds; D011522:Protons