Notch and PI3K: how is the road traveled?
In this issue of Blood,Wong et al present evidence that the Notch and phosphatidylinositol-3-kinase (PI3K) pathways cross-talk through a Hes1–phosphatase and tensin homolog (PTEN) axis during normal T-cell development.
University of Pennsylvania Perelman School of Medicine.
Will
W
Bailis
Warren S
WS
Pear
D000818:Animals; D051792:Basic Helix-Loop-Helix Proteins / Q000378:metabolism*; D002454:Cell Differentiation; D018398:Homeodomain Proteins / Q000378:metabolism*; D051059:PTEN Phosphohydrolase / Q000378:metabolism*; D016693:Receptors, Antigen, T-Cell, alpha-beta / Q000378:metabolism*; D060168:Thymocytes / Q000166:cytology* / Q000201:enzymology*; D000072056:Transcription Factor HES-1
D051792:Basic Helix-Loop-Helix Proteins; D018398:Homeodomain Proteins; D051059:PTEN Phosphohydrolase; D016693:Receptors, Antigen, T-Cell, alpha-beta; D000072056:Transcription Factor HES-1; C489734:Hes1 protein, mouse; C487757:Pten protein, mouse