Spiropyran-conjugated pluronic as a dual responsive colorimetric detector.
Novel spiropyran-conjugated Pluronic [polyethylene oxide (PEO)-b-polypropylene oxide (PPO)-b-polyethylene oxide (PEO)] micelles are developed as a new colorimetric detector showing photo- or thermo-switchable behavior. Facile conjugation of spiropyran to Pluronic was confirmed by (1)H NMR, UV-Vis, and Fluorescence spectroscopy. A switchable photoluminescence is found depending on the irradiation with either UV or visible light, and temperature resulting from structural isomerization of spiropyran between spiropyran (SP) and merocyanine (MC) form. Cytotoxicity of the spiropyran-conjugated Pluronic (SP-PL) was evaluated following an MTT assay, whereas photo responsiveness of spiropyran within the micelles was determined by confocal laser scanning microscopy.
Department of Chemical and Biological Engineering, Korea National University of Transportation, Chungju 380-702, Republic of Korea.
Yeon Jeong
YJ
Oh
Jeong A
JA
Nam
Abdullah
A
Al-Nahain
Sangkug
S
Lee
Insik
I
In
Sung Young
SY
Park
D001578:Benzopyrans / Q000737:chemistry*; D001672:Biocompatible Materials / Q000138:chemical synthesis / Q000737:chemistry / Q000633:toxicity; D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects / Q000528:radiation effects; D006801:Humans; D007211:Indoles / Q000737:chemistry*; D008027:Light; D008823:Micelles; D018613:Microscopy, Confocal; D009574:Nitro Compounds / Q000737:chemistry*; D011092:Polyethylene Glycols / Q000138:chemical synthesis / Q000737:chemistry* / Q000633:toxicity; D011409:Propylene Glycols / Q000138:chemical synthesis / Q000737:chemistry* / Q000633:toxicity; D013050:Spectrometry, Fluorescence; D014466:Ultraviolet Rays
D001578:Benzopyrans; D001672:Biocompatible Materials; D007211:Indoles; D008823:Micelles; D009574:Nitro Compounds; C116176:PEO-PPO-PEO; D011409:Propylene Glycols; C548873:merocyanine; C088184:spiropyran; D011092:Polyethylene Glycols