Prognosis and predictors of ACL reconstructions using the MOON cohort: a model for comparative effectiveness studies.
Injury to the anterior cruciate ligament (ACL) threatens an active lifestyle and exposes the patient to risk of early osteoarthritis (OA). ACL reconstruction is typically chosen by individuals to allow a return to their previous work and sports activities. Primary ACL reconstruction (ACLR) has in general been effective at restoring functional stability, but patients' modifiable predictors of both short- and long-term validated outcomes and OA are largely unknown. The Multicenter Orthopaedic Outcomes Network (MOON) consortium was established in 2002 to enroll and longitudinally follow a population cohort of ACL reconstructed patients. The objective was to establish patient-specific predictive models of clinically important outcomes. Over the past 10 years, the overarching aims of this NIAMS-funded prospective multicenter cohort of ACL reconstructions has been threefold: (1) to identify both short- and long-term prognosis and predictors of sports function, activity level, and general health through validated patient-reported outcomes, (2) to identify the symptoms and signs of OA, and (3) to quantify the incidence of ACL reconstruction graft and/or contralateral ACL failures and additional surgical procedures. This manuscript summarizes the Kappa Delta Ann Doner Vaughan Award paper and presentation at the 2012 ORS/AAOS Annual Meeting.
Vanderbilt University Medical Center, 4200 Medical Center East, South Tower, 1215 21st Avenue South, Nashville, Tennessee 37232-8774, USA. kurt.spindler@vanderbilt.edu
Kurt P
KP
Spindler
Richard D
RD
Parker
Jack T
JT
Andrish
Christopher C
CC
Kaeding
Rick W
RW
Wright
Robert G
RG
Marx
Eric C
EC
McCarty
Annunziato
A
Amendola
Warren R
WR
Dunn
Laura J
LJ
Huston
Frank E
FE
Harrell
D016118:Anterior Cruciate Ligament / Q000601:surgery*; D000070598:Anterior Cruciate Ligament Injuries; D059549:Anterior Cruciate Ligament Reconstruction / Q000592:standards*; D015331:Cohort Studies; D019317:Evidence-Based Medicine; D006801:Humans; D007718:Knee Injuries / Q000453:epidemiology* / Q000601:surgery*; D015233:Models, Statistical; D015999:Multivariate Analysis; D020370:Osteoarthritis, Knee / Q000453:epidemiology*; D011237:Predictive Value of Tests; D011379:Prognosis; D012307:Risk Factors