Effect of aspartame on circadian oscillations of calcium and inorganic phosphorus in rats.
The effect of aspartame on circadian rhythms of calcium and inorganic phosphorus levels was studied in rats. Acrophase delays in calcium rhythms and advances in inorganic phosphorus rhythms and alteration in mesor values in both rhythms were observed in aspartame-treated rats. However, no change in amplitude values was observed. Oral administration of aspartame leads to increased levels of aspartate in the brain, which could alter the characteristics of calcium and inorganic phosphorus rhythms, possibly by modulating transmission in several areas/nuclei in brain, including retinohypothalamic tract (RHT) and suprachiasmatic nuclei (SCN).
Department of Biochemistry, Faculty of Science, Annamalai University, Annamalainagar 608 002, Tamil Nadu, India.
P
P
Rajasekar
T
T
Manivasagam
P
P
Subramanian
D000284:Administration, Oral; D000818:Animals; D001218:Aspartame / Q000737:chemistry* / Q000494:pharmacology; D001671:Biochemistry / Q000379:methods; D001921:Brain / Q000187:drug effects / Q000378:metabolism; D002118:Calcium / Q000737:chemistry*; D009991:Oscillometry / Q000379:methods*; D010758:Phosphorus / Q000737:chemistry*; D051381:Rats; D017208:Rats, Wistar; D013493:Suprachiasmatic Nucleus / Q000187:drug effects / Q000378:metabolism; D013997:Time Factors
D010758:Phosphorus; D002118:Calcium; D001218:Aspartame