Intracellular self-assembly of nanoparticles for enhancing cell uptake.
A radioactive probe (1) has been developed and applied to a condensation reaction and self-assembly of radioactive nanoparticles (i.e., (125)I-NPs) intracellularly. Upon 160 min cellular efflux, the radioactivity retained in cells incubated with 1 was 4-fold more higher than that of those cells treated with a scrambled control probe (1-Scr).
CAS Key Laboratory of Soft Matter Chemistry, Department of Chemistry, University of Science and Technology of China, 96 Jinzhai Road, Hefei, Anhui, 230026, P. R. China.
Qingqing
Q
Miao
Xiaoyu
X
Bai
Yingying
Y
Shen
Bin
B
Mei
Jinhao
J
Gao
Li
L
Li
Gaolin
G
Liang
D052160:Benzothiazoles / Q000138:chemical synthesis / Q000737:chemistry / Q000493:pharmacokinetics*; D006801:Humans; D007457:Iodine Radioisotopes; D015394:Molecular Structure; D053758:Nanoparticles / Q000737:chemistry*; D009369:Neoplasms / Q000000981:diagnostic imaging* / Q000473:pathology; D011877:Radionuclide Imaging
D052160:Benzothiazoles; D007457:Iodine Radioisotopes