Applications of Connectivity Map in drug discovery and development.
Genome-wide expression profiling of gene transcripts has been successfully applied in biomedical discovery for over a decade. Based on the premises of this technology, Connectivity Map provides a data-driven and systematic approach for discovering associations among genes, chemicals and biological conditions such as diseases. Since its first introduction in 2006, the approach has shown emerging promises in uncovering avenues for drug discovery and development such as in identifying and suggesting new indications for existing drugs and elucidating mode of actions for novel chemicals in addition to potentially predicting side effects.
Computational Biology, GlaxoSmithKline, Research Triangle Park, NC 27709, USA. angela.x.qu@gsk.com
Xiaoyan A
XA
Qu
Deepak K
DK
Rajpal
D019295:Computational Biology / Q000379:methods*; D030541:Databases, Genetic; D055808:Drug Discovery / Q000379:methods*; D015507:Drugs, Investigational / Q000009:adverse effects / Q000494:pharmacology; D020869:Gene Expression Profiling; D020022:Genetic Predisposition to Disease; D055106:Genome-Wide Association Study; D006801:Humans; D054852:Small Molecule Libraries / Q000009:adverse effects / Q000494:pharmacology; D059467:Transcriptome / Q000235:genetics
D015507:Drugs, Investigational; D054852:Small Molecule Libraries