Higher soluble P-selectin is associated with chronic venous insufficiency: the San Diego Population Study.
BACKGROUND
P-selectin is a cell adhesion molecule shown to play a role in venous thromboembolism. We evaluated whether higher P-selectin is associated with chronic venous insufficiency (CVI).


METHODS
In a cohort of 2408 participants, the San Diego Population Study, peripheral venous disease was established by symptoms, clinical examination, and ultrasound. We measured P-selectin in a subsample of 352 CVI cases frequency matched to controls. Cases included four hierarchical groups of increasing severity of CVI.


RESULTS
The association of P-selectin with CVI considering all cases was weak, with an age, race and sex-adjusted odds ratio (OR) of 1.3 (95% CI 1.0-2.2) for values in the 3rd versus 1st tertile. The OR for cases in the two most severe groups was 2.3 (95% CI 1.2-4.2). Addition of body mass index to the model reduced this OR to 1.9 (95% CI 1.0-3.6).


CONCLUSIONS
Higher circulating P-selectin was associated with more severe CVI, but not CVI overall. Results support that platelet and endothelial cell activation may be involved in the pathogenesis of CVI.
University of Vermont, Department of Medicine, Colchester, VT 05446, USA.
Locke J
LJ
Bryan
Peter W
PW
Callas
Michael H
MH
Criqui
Mary
M
Cushman
D002140:California / Q000453:epidemiology; D016022:Case-Control Studies; D015331:Cohort Studies; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D019007:P-Selectin / Q000378:metabolism*; D012307:Risk Factors; D014689:Venous Insufficiency / Q000453:epidemiology / Q000378:metabolism*
D019007:P-Selectin