Clinical and cytogenetic characteristics of myelodysplastic syndrome in patients with HIV infection.
We report eight patients of myelodysplastic syndrome (MDS) with HIV infection. Compared to a historical cohort of HIV-uninfected MDS patients, HIV/MDS were younger (p=0.019), had more complex cytogenetics (p=0.015), and more often had 7q deletion or monosomy 7 (p=0.011). In five patients, HIV/MDS transformed to acute myeloid leukemia, with a median time to transformation of 7 months. Also, the median overall survival was shorter in the HIV/MDS than in their HIV-uninfected counterparts (8 vs. 22 months; p=0.003). These results suggest that HIV/MDS is a high-risk MDS necessitating thorough cytogenetic analysis and follow-up.
Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA. ktakahashi@mdanderson.org
Koichi
K
Takahashi
Mariko
M
Yabe
Ilan
I
Shapira
Sherry
S
Pierce
Guillermo
G
Garcia-Manero
Mala
M
Varma
D000328:Adult; D000368:Aged; D002471:Cell Transformation, Neoplastic / Q000235:genetics; D005260:Female; D015658:HIV Infections / Q000150:complications* / Q000235:genetics* / Q000401:mortality; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D053208:Kaplan-Meier Estimate; D015470:Leukemia, Myeloid, Acute / Q000209:etiology; D008297:Male; D008875:Middle Aged; D009190:Myelodysplastic Syndromes / Q000150:complications* / Q000235:genetics* / Q000401:mortality; D011379:Prognosis