Cholestasis and growth in neonates with gastroschisis.
OBJECTIVE
The aim of this study was to determine the incidence of cholestasis and the correlation between cholestasis and weight-for-age z scores in parenteral nutrition-dependent neonates with gastroschisis.


METHODS
A single-center retrospective review of 59 infants born with gastroschisis from January 2000 to June 2007 was conducted. Demographic and clinical data were collected and analyzed. Subjects were divided into cholestatic and noncholestatic groups. Statistical analyses included the Student t test, Wilcoxon rank sum test, Fisher exact test, and a general linear model.


RESULTS
Fifty-nine neonates with gastroschisis were identified, and 16 (28%) of 58 patients developed cholestasis. Younger gestational age and cholestasis were found to be independently associated with weight-for-age z score in 30 of 58 patients with available long-term follow-up data.


CONCLUSIONS
Parenteral nutrition-dependent neonates with gastroschisis remain at considerable risk for the development of cholestasis. Both gestational age and cholestasis were found to be independent risk factors, predisposing these neonates to poor postnatal growth.
The Department of Surgery and The Vascular Biology Program, Children's Hospital Boston, Harvard Medical School, Boston, MA 02115, USA.
Erica M
EM
Fallon
Paul D
PD
Mitchell
Alexis K
AK
Potemkin
Deepika
D
Nehra
Danielle A
DA
Arsenault
Elizabeth M
EM
Robinson
David
D
Zurakowski
Megan
M
Brenn
Jonathan A
JA
Meisel
Mark
M
Puder
D058107:Abdominal Wound Closure Techniques; D001724:Birth Weight; D001835:Body Weight; D002779:Cholestasis / Q000453:epidemiology* / Q000209:etiology; D005260:Female; D020139:Gastroschisis / Q000601:surgery / Q000628:therapy*; D005865:Gestational Age; D006130:Growth Disorders / Q000453:epidemiology* / Q000209:etiology; D006801:Humans; D015994:Incidence; D007231:Infant, Newborn; D007234:Infant, Premature; D007235:Infant, Premature, Diseases / Q000453:epidemiology; D007410:Intestinal Diseases / Q000453:epidemiology; D007902:Length of Stay / Q000706:statistics & numerical data; D016031:Liver Transplantation; D008297:Male; D010288:Parenteral Nutrition / Q000009:adverse effects*; D011183:Postoperative Complications / Q000453:epidemiology / Q000209:etiology; D012189:Retrospective Studies; D012307:Risk Factors; D018805:Sepsis / Q000453:epidemiology