Anti-inflammatory effects of low-dose radiotherapy. Indications, dose, and radiobiological mechanisms involved.
Low-dose radiotherapy (LD-RT) has been used for several benign diseases, including arthrodegenerative and inflammatory pathologies. Despite its effectiveness in clinical practice, little is known about the mechanisms through which LD-RT modulates the various phases of the inflammatory response and about the optimal dose fractionation. The objective of this review is to deepen knowledge about the most effective LD-RT treatment schedule and radiobiological mechanisms underlying the anti-inflammatory effects of LD-RT in various in vitro experiments, in vivo studies, and clinical studies.
Radiation Oncology Department. Hospital Universitari Sant Joan de Reus, Institut d'Investigacions Sanitàries Pere Virgili, Universitat Rovira i Virgili, C/Sant Joan, 43200, Reus, Spain. marenas@grupsagessa.com
M
M
Arenas
S
S
Sabater
V
V
Hernández
A
A
Rovirosa
P C
PC
Lara
A
A
Biete
J
J
Panés
D000818:Animals; D015815:Cell Adhesion Molecules / Q000097:blood; D016207:Cytokines / Q000097:blood; D004195:Disease Models, Animal; D006801:Humans; D007111:Immunity, Cellular / Q000276:immunology / Q000528:radiation effects; D007249:Inflammation / Q000276:immunology / Q000532:radiotherapy*; D018836:Inflammation Mediators / Q000097:blood; D036904:Leukocyte Rolling / Q000276:immunology / Q000528:radiation effects; D007962:Leukocytes / Q000276:immunology / Q000528:radiation effects; D020370:Osteoarthritis, Knee / Q000276:immunology / Q000532:radiotherapy; D011879:Radiotherapy Dosage
D015815:Cell Adhesion Molecules; D016207:Cytokines; D018836:Inflammation Mediators