Vitamin D and drug-metabolising enzymes.
Experimental studies on the molecular regulation of human drug metabolism have revealed that vitamin D up-regulates transcription of several key enzymes, such as CYP3A4, through the vitamin D receptor pathway in intestinal and hepatic cells. Recent data suggest that this results in seasonal changes with higher clearance of orally administered drugs during periods with high UV-B radiation and vitamin D levels. Taken together, vitamin D status might contribute to inter- and intraindividual differences in drug metabolism, but the therapeutic impact of these findings remains to be established.
Karolinska Institutet, Department of Laboratory Medicine, Clinical Pharmacology, Karolinska University Hospital Huddinge, Stockholm, Sweden.
Jonatan D
JD
Lindh
Linda
L
Björkhem-Bergman
Erik
E
Eliasson
D018938:Caco-2 Cells; D016572:Cyclosporine / Q000493:pharmacokinetics; D051544:Cytochrome P-450 CYP3A / Q000235:genetics / Q000378:metabolism; D006207:Half-Life; D006801:Humans; D008658:Inactivation, Metabolic; D004364:Pharmaceutical Preparations / Q000378:metabolism; D018167:Receptors, Calcitriol / Q000235:genetics / Q000378:metabolism; D020123:Sirolimus / Q000493:pharmacokinetics; D016559:Tacrolimus / Q000493:pharmacokinetics; D014466:Ultraviolet Rays; D014807:Vitamin D / Q000097:blood / Q000378:metabolism*
D004364:Pharmaceutical Preparations; D018167:Receptors, Calcitriol; D014807:Vitamin D; D016572:Cyclosporine; D051544:Cytochrome P-450 CYP3A; C510163:CYP3A4 protein, human; D020123:Sirolimus; D016559:Tacrolimus