A quantitative model of human jejunal smooth muscle cell electrophysiology.
Recently, a number of ion channel mutations have been identified in the smooth muscle cells of the human jejunum. Although these are potentially significant in understanding diseases that are currently of unknown etiology, no suitable computational cell model exists to evaluate the effects of such mutations. Here, therefore, a biophysically based single cell model of human jejunal smooth muscle electrophysiology is presented. The resulting cellular description is able to reproduce experimentally recorded slow wave activity and produces realistic responses to a number of perturbations, providing a solid platform on which the causes of intestinal myopathies can be investigated.
Department of Bioengineering, National University of Singapore, Singapore, Singapore.
Yong Cheng
YC
Poh
Alberto
A
Corrias
Nicholas
N
Cheng
Martin Lindsay
ML
Buist
D015220:Calcium Channels / Q000378:metabolism; D004558:Electric Stimulation; D055724:Electrophysiological Phenomena; D006801:Humans; D007583:Jejunum / Q000166:cytology*; D007700:Kinetics; D008954:Models, Biological; D032389:Myocytes, Smooth Muscle / Q000166:cytology* / Q000378:metabolism
D015220:Calcium Channels