Nanocarriers for dermal drug delivery: influence of preparation method, carrier type and rheological properties.
Nanocarriers are highly interesting delivery systems for the dermal application of drugs. Based on a eudermic alkylpolyglycosid nanoemulsions, solid lipid nanoparticles (SLN) and nano-structured lipid carriers (NLC) were prepared by ultrasonic dispersion. The ultrasound preparation technique turned out to be convenient and rapid. For reasons of comparison, nanoemulsions were also prepared by high-pressure homogenisation with highly similar physicochemical properties. Cryo electron microscopy was employed to elucidate the microstructure of the ultrasound-engineered nanocarriers. Furthermore, in vitro skin experiments showed excellent skin permeation and penetration properties for flufenamic acid from all formulations. Moreover, ATR-FTIR studies revealed barrier-restorative properties for NLC and SLN. Furthermore, the rheological characteristics of all nanocarriers were determined. In order to increase the viscosity, three different polymers were employed to also prepare semi-solid NLC drug delivery systems. All of them exhibited comparable skin diffusion properties, but may offer improved dermal applicability.
University of Vienna, Research Platform Characterisation of Drug Delivery Systems on Skin and Investigation of Involved Mechanisms, Althanstrasse 14, 1090 Vienna, Austria.
Julia C
JC
Schwarz
Angelika
A
Weixelbaum
Elisabeth
E
Pagitsch
Monika
M
Löw
Guenter P
GP
Resch
Claudia
C
Valenta
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage; D004337:Drug Carriers / Q000008:administration & dosage / Q000737:chemistry*; D004339:Drug Compounding / Q000379:methods*; D004655:Emulsions; D005439:Flufenamic Acid / Q000008:administration & dosage; D005936:Glucans / Q000737:chemistry; D005990:Glycerol / Q000031:analogs & derivatives / Q000737:chemistry; D066298:In Vitro Techniques; D053758:Nanoparticles / Q000008:administration & dosage / Q000737:chemistry*; D012212:Rheology; D012867:Skin / Q000378:metabolism; D012869:Skin Absorption; D013228:Stearates / Q000737:chemistry; D013501:Surface-Active Agents / Q000737:chemistry; D013552:Swine; D014280:Triglycerides / Q000737:chemistry
D000893:Anti-Inflammatory Agents; D004337:Drug Carriers; D004655:Emulsions; D005936:Glucans; C558491:Plantacare 810; D013228:Stearates; D013501:Surface-Active Agents; D014280:Triglycerides; C529864:glycerol 1-stearate; C022834:miglyol 812; D005439:Flufenamic Acid; D005990:Glycerol