[Long-term follow-up and therapy of adult Wilms' tumor].
OBJECTIVE
To investigate and analyze the treatment and Long-term follow-up results of adult Wilms' tumor.


METHODS
Medical records for  diagnosed Wilms' tumor in patients aged more than 15 years from Jan. 1970 to Dec. 2011 were reviewed retrospectively. The clinical presentations,  stages, operative details, pathologic findings, adjuvant therapies and outcomes were analyzed. All the patients received regular follow-up, and particular  attention was paid to the median follow-up period and tumor specific survival time.


RESULTS
The records revealed the 10 patients with a median age of  33.5 year. Male and female were each 5. Left was 4 and right was 6. In the study, 80% of the patients had clinical presentations, and 30% of the patients  presented with abdominal mass, and 30% of the patients had distant metastasis at the time of diagnosis. The number of the patients with tumor stages I,II, III, and IV were 2, 1, 4, and 3. One patient just underwent fine needle biopsy due to advanced tumor stage, and the others underwent surgical operations.  The range of the follow-up time was 12 to 187 months, and the median follow-up period was 20 months. One patient lost the follow up , 5 patients died, 2  patients survived with tumor recurrence, and 2 patients survived without tumor recurrence. The median survival period was 42 months, and one patient lost  the follow-up.


CONCLUSIONS
The Long-term follow-up data demonstrated the poor prognosis of adult Wilms' tumor. Early tumor stage and the  combination of operation, radiotherapy and chemotherapy are key factors to improve the outcomes.
Department of Urology, Peking University First Hospital, Beijing, China.
Cui-jian
CJ
Zhang
Xue-song
XS
Li
Wei
W
Yu
Wen-han
WH
Wu
Zhi-song
ZS
He
Jie
J
Jin
Li-qun
LQ
Zhou
D000293:Adolescent; D000328:Adult; D000367:Age Factors; D003131:Combined Modality Therapy; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007680:Kidney Neoplasms / Q000601:surgery* / Q000628:therapy; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D012189:Retrospective Studies; D009396:Wilms Tumor / Q000601:surgery* / Q000628:therapy