Facile synthesis of 2-pyrazolines and α,β-diamino ketones via regioselective ring-opening of hydrazone-tethered aziridines.
A facile strategy to access 2-pyrazolines and α,β-diamino ketones via SN(2)-type ring-opening of N-(aziridin-2-ylethylidene)hydrazines or N-(aziridin-2-ylbutylidene)hydrazines in the presence of Lewis acid or trifluoromethanesulfonic acid (TfOH) is described in this context.
Key Laboratory for Advanced Materials and Institute of Fine Chemicals, East China University of Science and Technology, 130 MeiLong Road, Shanghai, 200237, P. R. China.
Zhen
Z
Zhang
De
D
Wang
Yin
Y
Wei
Min
M
Shi
D001388:Aziridines / Q000737:chemistry*; D006835:Hydrazones / Q000737:chemistry*; D007659:Ketones / Q000138:chemical synthesis* / Q000737:chemistry; D008968:Molecular Conformation; D011720:Pyrazoles / Q000138:chemical synthesis* / Q000737:chemistry; D013237:Stereoisomerism
D001388:Aziridines; D006835:Hydrazones; D007659:Ketones; D011720:Pyrazoles