A proximity-dependent surface hybridization strategy for constructing an efficient signal-on electrochemical DNAzyme sensing system.
A proximity-dependent surface hybridization strategy is employed for designing a "signal-on" electrochemical DNAzyme biosensor. By taking advantage of the high sensitivity of the PDSH strategy, and by realizing the enzymatic hydrolysis reaction in a homogenous system with a unimolecular design, the proposed biosensor shows a very high sensitivity to target molecules.
Molecular Science and Biomedicine Laboratory, State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, Changsha 410082, China.
Rong
R
Hu
Ting
T
Fu
Xiao-Bing
XB
Zhang
Rong-Mei
RM
Kong
Li-Ping
LP
Qiu
Ya-Ru
YR
Liu
Xiao-Tong
XT
Liang
Weihong
W
Tan
Guo-Li
GL
Shen
Ru-Qin
RQ
Yu
D015374:Biosensing Techniques; D004247:DNA / Q000737:chemistry / Q000378:metabolism; D021881:DNA, Catalytic / Q000737:chemistry* / Q000378:metabolism; D055664:Electrochemical Techniques; D004566:Electrodes; D006046:Gold / Q000737:chemistry; D009693:Nucleic Acid Hybridization; D013499:Surface Properties
D021881:DNA, Catalytic; D006046:Gold; D004247:DNA