How a mismatch repair enzyme balances the needs for efficient lesion processing and minimal action on undamaged DNA.
Comment on: Maiti A, et al. Proc Natl Acad Sci USA 2012; 109:8091-6.
Alexander C
AC
Drohat
Edwin
E
Pozharski
Atanu
A
Maiti
D055162:Biocatalysis; D020134:Catalytic Domain; D017124:Conserved Sequence; D018899:CpG Islands; D004247:DNA / Q000378:metabolism; D004249:DNA Damage; D053843:DNA Mismatch Repair; D006801:Humans; D009154:Mutation / Q000235:genetics; D044502:Thymine DNA Glycosylase / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*
D004247:DNA; D044502:Thymine DNA Glycosylase