[Developmental origins of health and disease in adults: role of maternal environment].
Many epidemiological studies indicate that environmental conditions during embryonic and fetal development can have an impact on health at adulthood. Animal studies clearly demonstrate that maternal, and even paternal undernutrition or nutritional excess durably modify some epigenetic marks in their offspring, affecting gene expression and physiological adaptations to the environment. It is crucial to better define the effects of early environment on adult phenotype and epigenetic marks in humans and to develop, with the help of animal models, new preventive strategies and treatments.
Inra, UMR 1198 biologie du développement et reproduction, domaine de Vilvert, bâtiment 231, 78352 Jouy-en-Josas cedex, France. pascale.chavatte@jouy.inra.fr
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Chavatte-Palmer
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Tarrade
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Lévy
D000328:Adult; D000818:Animals; D004813:Epidemiology; D044127:Epigenesis, Genetic; D005220:Fathers; D005260:Female; D047109:Fetal Development; D005317:Fetal Growth Retardation; D006304:Health Status; D006801:Humans; D008297:Male; D044342:Malnutrition / Q000150:complications; D024821:Metabolic Syndrome; D009765:Obesity / Q000150:complications; D044343:Overnutrition / Q000150:complications; D011247:Pregnancy; D011248:Pregnancy Complications; D011297:Prenatal Exposure Delayed Effects