Multicomponent and sequential organocatalytic reactions: diversity with atom-economy and enantiocontrol.
Reactions in which several components are combined in sequence, and without isolation of intermediates, are greatly sought because of the inherent molecular diversity, efficiency, and atom-economy. However, organocatalytic reactions, employing an organic catalyst to assemble products of high enantiomeric excess (a single optical isomer), are also cutting-edge methodology. This tutorial review covers the overlap of these two areas, outling the structural diversity and stereocontrol arising from one-pot combinations of at least three components, powerful approaches with great potential that minimise formation of by-products and operating costs.
Department of Chemistry, University College London, Christopher Ingold Laboratories, UK. c.m.marson@ucl.ac.uk
Charles M
CM
Marson
D000447:Aldehydes / Q000737:chemistry; D000475:Alkenes / Q000737:chemistry; D002264:Carboxylic Acids / Q000737:chemistry; D002384:Catalysis; D006571:Heterocyclic Compounds / Q000737:chemistry; D007097:Imines / Q000737:chemistry; D007659:Ketones / Q000737:chemistry; D009930:Organic Chemicals / Q000737:chemistry*; D013237:Stereoisomerism
D000447:Aldehydes; D000475:Alkenes; D002264:Carboxylic Acids; D006571:Heterocyclic Compounds; D007097:Imines; D007659:Ketones; D009930:Organic Chemicals