Genome-wide approaches (GWA) in oral and craniofacial diseases research.
Oral Diseases (2012) Underlying molecular genetic mechanisms of diseases can be deciphered with unbiased strategies using recently developed technologies enabling genome-wide scale investigations. These technologies have been applied in scanning for genetic variations, gene expression profiles, and epigenetic changes for oral and craniofacial diseases. However, these approaches as applied to oral and craniofacial conditions are in the initial stages, and challenges remain to be overcome, including analysis of high throughput data and their interpretation. Here, we review methodology and studies using genome-wide approaches in oral and craniofacial diseases and suggest future directions.
National Institute of Nursing Research, National Institutes of Health, Bethesda, MD School of Dentistry, University of Maryland, Baltimore, MD, USA.
H
H
Kim
S
S
Gordon
R
R
Dionne
D035843:Biomedical Research; D005145:Face; D055106:Genome-Wide Association Study; D006801:Humans; D009059:Mouth Diseases / Q000235:genetics*; D009140:Musculoskeletal Diseases / Q000235:genetics*; D012886:Skull