[Progress in the understanding of the function of atypical response regulators: a review].
Two component system is a signal transduction system. It typically consists of a sensor histitine kinase and a cognate response regulator (RR) component. The activity of RR is regulated by a phosphorylation dependent mechanism. In recent years, the existence of atypical response regulators (ARRs), which rely on a phosphorylation independent mechanism to regulate their activity, have been recognized. ARRs are involved in the regulation of bacterial growth and development, antibiotic biosynthesis, iron transport, among others. Here we review the recent advances in the understanding of the structure and function of atypical response regulators, by using JadR1, a regulator in jadomycin biosynthesis in Streptomyces, as an example to elucidate the novel mechanism used by ARR to fine-tune its activity.
School of Chemical and Environmental Engineering, China University of Mining and Technology (Beijing), Beijing 100083, China.
Xiaojing
X
Peng
Junjie
J
Ji
Yuxiu
Y
Zhang
Keqian
K
Yang
Hongmei
H
Zhang
Hui
H
Zhu
D001426:Bacterial Proteins / Q000235:genetics; D015964:Gene Expression Regulation, Bacterial; D018507:Gene Expression Regulation, Developmental; D005809:Genes, Regulator / Q000235:genetics; D000071677:Histidine Kinase; D007546:Isoquinolines / Q000378:metabolism; D009285:Naphthoquinones / Q000378:metabolism; D010766:Phosphorylation; D011494:Protein Kinases / Q000235:genetics*; D016601:RNA-Binding Proteins / Q000235:genetics; D015398:Signal Transduction; D013302:Streptomyces / Q000378:metabolism; D014157:Transcription Factors / Q000235:genetics
D001426:Bacterial Proteins; C415990:FrzS protein, Myxococcus xanthus; C501059:HP1043 protein, Helicobacter pylori; D007546:Isoquinolines; D009285:Naphthoquinones; D016601:RNA-Binding Proteins; D014157:Transcription Factors; C064872:antiterminator proteins, Bacteria; C506597:jadomycin A; C081750:jadomycin B; D011494:Protein Kinases; D000071677:Histidine Kinase