Enantioselective aza-Henry reactions of cyclic α-carbonyl ketimines under bifunctional catalysis.
The aza-Henry reaction of nitroalkanes with the C=N group of 2-aryl-3H-indol-3-ones catalyzed by thiourea-chincona derivatives takes place with good yield and high ee's.
Departamento de Química Orgánica (Módulo 1), Facultad de Ciencias, Universidad Autónoma de Madrid, Cantoblanco, 28049-Madrid, Spain.
Alejandro
A
Parra
Ricardo
R
Alfaro
Leyre
L
Marzo
Alberto
A
Moreno-Carrasco
José Luis
JL
García Ruano
José
J
Alemán
D000473:Alkanes / Q000138:chemical synthesis* / Q000737:chemistry; D002384:Catalysis; D007097:Imines / Q000737:chemistry*; D007211:Indoles / Q000737:chemistry*; D015394:Molecular Structure; D009570:Nitriles / Q000737:chemistry*; D009574:Nitro Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D013237:Stereoisomerism
D000473:Alkanes; D007097:Imines; D007211:Indoles; D009570:Nitriles; D009574:Nitro Compounds; C542835:ketimine