Leonurenones A-C: Labdane diterpenes from Leonotis leonurus.
Labdanes, leonurenones A-C, two known labdanes, luteolin 7-O-β-glucoside and luteolin were isolated and characterized from a commercial source of Leonotis leonurus. Genetic methods allowed for identification of the plant material. The leonurenones contain an uncommon α,β-unsaturated enone moiety in ring B, and leonurenones A and B were evaluated in a competitive inhibition assay at the GABA A neuroreceptor site.
Department of Chemistry, Hunter College, City University of New York, NY 10065, USA.
Fang
F
He
Charlotte
C
Lindqvist
Wayne W
WW
Harding
D001665:Binding Sites / Q000187:drug effects; D004224:Diterpenes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D019686:Lamiaceae / Q000737:chemistry*; D008968:Molecular Conformation; D011963:Receptors, GABA-A / Q000378:metabolism*; D013237:Stereoisomerism; D013329:Structure-Activity Relationship
D004224:Diterpenes; D011963:Receptors, GABA-A; C433017:labdane; C582635:leonurenone A; C582637:leonurenone B; C582636:leonurenone C