Hyperspectral imaging based method for fast characterization of kidney stone types.
The formation of kidney stones is a common and highly studied disease, which causes intense pain and presents a high recidivism. In order to find the causes of this problem, the characterization of the main compounds is of great importance. In this sense, the analysis of the composition and structure of the stone can give key information about the urine parameters during the crystal growth. But the usual methods employed are slow, analyst dependent and the information obtained is poor. In the present work, the near infrared (NIR)-hyperspectral imaging technique was used for the analysis of 215 samples of kidney stones, including the main types usually found and their mixtures. The NIR reflectance spectra of the analyzed stones showed significant differences that were used for their classification. To do so, a method was created by the use of artificial neural networks, which showed a probability higher than 90% for right classification of the stones. The promising results, robust methodology, and the fast analytical process, without the need of an expert assistance, lead to an easy implementation at the clinical laboratories, offering the urologist a rapid diagnosis that shall contribute to minimize urolithiasis recidivism.
Universitat Autònoma de Barcelona, Centre Grup de Tècniques de Separació en Química (GTS), Unitat de Química Analítica, Departament de Química, 08193 Bellaterra, Spain.
Francisco
F
Blanco
Montserrat
M
López-Mesas
Silvia
S
Serranti
Giuseppe
G
Bonifazi
Josef
J
Havel
Manuel
M
Valiente
D000465:Algorithms; D006801:Humans; D007089:Image Enhancement / Q000379:methods; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D007669:Kidney Calculi / Q000737:chemistry* / Q000145:classification / Q000175:diagnosis*; D061848:Optical Imaging / Q000379:methods*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D019265:Spectroscopy, Near-Infrared / Q000379:methods*