Antiviral triterpenoid saponins from the roots of Ilex asprella.
Two new sulfur-containing triterpenoid saponins, asprellanosides A (1) and B (2), were isolated from the roots of Ilex asprella, together with 10 known compounds (3-12). An in vitro anti-HSV-1 activity test of the isolates (1-4, 6-7, and 9-12) showed that only asprellanoside A (1) and oblonganoside H (6) exhibited anti-HSV-1 activity with TIC values of 0.14 and 0.18 mM, respectively.
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, People's Republic of China.
Min
M
Zhou
Min
M
Xu
Xiao-Xia
XX
Ma
Kai
K
Zheng
Ke
K
Yang
Chong-Ren
CR
Yang
Yi-Fei
YF
Wang
Ying-Jun
YJ
Zhang
D000998:Antiviral Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D018259:Herpesvirus 1, Human / Q000187:drug effects*; D030017:Ilex / Q000737:chemistry*; D008516:Medicine, Chinese Traditional; D008958:Models, Molecular; D015394:Molecular Structure; D018517:Plant Roots / Q000737:chemistry; D012503:Saponins / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D014315:Triterpenes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*
D000998:Antiviral Agents; D004365:Drugs, Chinese Herbal; D012503:Saponins; D014315:Triterpenes; C580561:asprellanoside A; C580560:asprellanoside B