Treatment of central giant cell lesions using bisphosphonates with intralesional corticosteroid injections.
Central giant cell lesions are benign intraosseous proliferative lesions that have considerable local aggressiveness. Nonsurgical treatment methods, such as intralesional corticosteroid injections, systemic calcitonin and interferon have been reported. Recently, bisphosphonates have been used to treat central giant cell lesions. A case of a 36-year-old male with a central giant cell lesion crossing the mandibular midline was treated with intralesional corticosteroids combined with alendronate sodium for the control of systemic bone resorption. The steroid injections and the use of bisphosphonates were stopped after seven months when further needle penetration into the lesion was not possible due to new bone formation. After two years, the bony architecture was near normal, and only minimal radiolucency was present around the root apices of the involved teeth. The patient was followed up for four years, and panoramic radiography showed areas of new bone formation. Thus far, neither recurrence nor side effects of the medication have been detected.
School of Dentistry, Federal University of Pará-UFPA, Avenida Augusto Corrêa, 01, Belém, PA, 66075-110, Brazil.
Newton Guerreiro Júnior
NG
da Silva
Aline Semblano Dias
AS
Carreira
Erick Nelo
EN
Pedreira
Fabrício Mesquita
FM
Tuji
Karem López
KL
Ortega
João
J
de Jesus Viana Pinheiro
D000305:Adrenal Cortex Hormones / Q000627:therapeutic use*; D000328:Adult; D004164:Diphosphonates / Q000627:therapeutic use*; D006101:Granuloma, Giant Cell / Q000000981:diagnostic imaging / Q000188:drug therapy*; D006801:Humans; D015552:Injections, Intralesional; D008297:Male; D008336:Mandibular Diseases / Q000000981:diagnostic imaging / Q000188:drug therapy*; D011862:Radiography, Panoramic
D000305:Adrenal Cortex Hormones; D004164:Diphosphonates