Anticomplement and antimicrobial activities of flavonoids from Entada phaseoloides.
Seventeen flavonoids isolated from the extracts of the stem of Entada phaseoloides were investigated for their anticomplement (both classic and alternative pathways) and antimicrobial activities against Gram-positive bacteria (MRSA, MSSA, Standard Enterococcus and Bacillus subtilis), Gram-negative bacteria (Escherichia coli, Pseudomonas aeuroginosa) and the yeast-like pathogenic fungus Candida albicans. The anticomplement studies revealed a dose-dependent activity among isolated quercetin, luteolin, apigenin, galangin, 5,2',5'-trihydroxy-3,7,4'-trimethoxyflavone-2'-O-beta-D-glucoside (+)-3,3',5',5,7-pentahydroflavanone, (+)-dihydrokaempferol, (-)-epicatechin, (+)-catechin, naringenin, and 5,7,3',5'-tetrahydroxyflavanone, and the antimicrobial results indicated that quercetin, 5,7,4'-trihydroxy-3'-methoxyflavonol and galangin produced the inhibitory activities against MRSA, MSSA, and Standard Enterococcus, while luteolin and rhamnocitrin displayed inhibition against only MRSA and MSSA. To the best of our knowledge, this is the first report that describes the anticomplement and antimicrobial activities of the stem of E. phaseoloides.
School of Pharmacy, Shanghai Jiao Tong University, Shanghai 200240, PR China.
Ke
K
Li
Shihua
S
Xing
Mengyue
M
Wang
Ying
Y
Peng
Yuqiong
Y
Dong
Xiaobo
X
Li
D000890:Anti-Infective Agents / Q000737:chemistry* / Q000494:pharmacology; D002392:Catechin / Q000737:chemistry / Q000494:pharmacology; D003169:Complement Inactivator Proteins / Q000737:chemistry* / Q000494:pharmacology; D016983:Enterococcus / Q000187:drug effects; D007887:Fabaceae / Q000737:chemistry*; D044950:Flavanones / Q000737:chemistry / Q000494:pharmacology; D005419:Flavonoids / Q000737:chemistry* / Q000494:pharmacology; D055624:Methicillin-Resistant Staphylococcus aureus / Q000187:drug effects; D015394:Molecular Structure; D011794:Quercetin / Q000737:chemistry / Q000494:pharmacology
D000890:Anti-Infective Agents; D003169:Complement Inactivator Proteins; D044950:Flavanones; D005419:Flavonoids; C012749:anticomplement; C037032:galangin; C080220:aromadedrin; D002392:Catechin; D011794:Quercetin; C005273:naringenin