Principles and roles of mRNA localization in animal development.
Intracellular targeting of mRNAs has long been recognized as a means to produce proteins locally, but has only recently emerged as a prevalent mechanism used by a wide variety of polarized cell types. Localization of mRNA molecules within the cytoplasm provides a basis for cell polarization, thus underlying developmental processes such as asymmetric cell division, cell migration, neuronal maturation and embryonic patterning. In this review, we describe and discuss recent advances in our understanding of both the regulation and functions of RNA localization during animal development.
Institute of Biology Valrose, University of Nice-Sophia Antipolis/UMR7277 CNRS/UMR1091 INSERM, Parc Valrose, 06108 Nice Cedex 2, France.
Caroline
C
Medioni
Kimberly
K
Mowry
Florence
F
Besse
D000818:Animals; D060049:Asymmetric Cell Division / Q000235:genetics / Q000502:physiology; D019521:Body Patterning / Q000235:genetics / Q000502:physiology; D016764:Cell Polarity / Q000235:genetics / Q000502:physiology; D003593:Cytoplasm / Q000378:metabolism; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism*
D012333:RNA, Messenger