The effects of repeated intravenous iohexol administration on renal function in healthy beagles--a preliminary report.
BACKGROUND
Contrast induced nephrotoxicity (CIN) is a well described syndrome in humans undergoing contrast medium examinations. To date CIN has received minimal attention in the veterinary literature despite increasing use of contrast medium examinations in computed tomographic studies.


METHODS
This prospective study evaluated the effect of 1290 mg/kg iohexol given intravenously to 5 normal beagle dogs in a divided dose at an interval of 6-8 weeks. Renal function was evaluated by means of scintigraphically determined glomerular filtration rate (GFR) and a variety of laboratory assays.


RESULTS
Only GFR showed a significant decrease (17%) after the second injection but not to a clinically or pathologically significant level.


CONCLUSIONS
No clinically significant effect of repeated contrast medium administration was determined in this limited study. However in dogs with reduced renal function the risk of CIN is likely to increase dramatically post contrast administration.
Department of Companion Animal Clinical Studies, Faculty of Veterinary Science, University of Pretoria, Private Bag X04, Onderstepoort 0110, Republic of South Africa. robert.kirberger@up.ac.za
Robert M
RM
Kirberger
Nicolette
N
Cassel
Ann
A
Carstens
Amelia
A
Goddard
D000818:Animals; D001774:Blood Chemical Analysis / Q000662:veterinary; D003287:Contrast Media / Q000633:toxicity*; D004285:Dogs; D005260:Female; D005919:Glomerular Filtration Rate / Q000187:drug effects / Q000662:veterinary*; D007275:Injections, Intravenous / Q000662:veterinary; D007472:Iohexol / Q000633:toxicity*; D007668:Kidney / Q000187:drug effects* / Q000502:physiology; D007677:Kidney Function Tests / Q000662:veterinary; D008297:Male; D011446:Prospective Studies; D011877:Radionuclide Imaging / Q000662:veterinary; D013997:Time Factors
D003287:Contrast Media; D007472:Iohexol