Association between lysyl oxidase G473A polymorphism and ovarian cancer in the Han Chinese population.
OBJECTIVE
Lysyl oxidase (LOX) is an extracellular enzyme critical for the cross-linking of collagens and elastin. A single-nucleotide polymorphism of LOX G473A is associated with various diseases. This retrospective study investigated the association between LOX G473A  polymorphism and susceptibility to ovarian cancer in the Han Chinese population.


METHODS
The LOX variant G473A was detected by polymerase chain reaction-restriction fragment length polymorphism in patients with ovarian cancer and healthy control subjects.


RESULTS
The frequencies  of the LOX 473AA genotype and the A allele were significantly higher in patients with ovarian cancer (n = 318) than in control subjects (n = 406) (odds ratio [OR] 2.30, 95% confidence interval [CI] 1.36, 3.87; OR 1.57, 95% CI 1.23, 2.00; respectively). The prevalence of  the GA genotype, AA genotype and A allele were significantly higher in patients with more advanced stages of ovarian cancer compared with those with primary stage disease.


CONCLUSIONS
This study suggests that LOX G473A polymorphism is a new risk factor for ovarian cancer and that LOX  protein might be a possible therapeutic target in ovarian cancer.
Department of Gynaecology, Yantai Yuhuangding Hospital, Qingdao University, Shandong Province, China.
X
X
Wang
J-L
JL
Cong
L-Y
LY
Qu
L
L
Jiang
Y
Y
Wang
D000368:Aged; D001483:Base Sequence; D016022:Case-Control Studies; D002681:China; D017931:DNA Primers; D005006:Ethnicity / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D008875:Middle Aged; D010051:Ovarian Neoplasms / Q000235:genetics*; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic; D012150:Polymorphism, Restriction Fragment Length; D008249:Protein-Lysine 6-Oxidase / Q000235:genetics*; D012189:Retrospective Studies
D017931:DNA Primers; D008249:Protein-Lysine 6-Oxidase