Linear ubiquitination of NEMO brakes the antiviral response.
NEMO is a key component of antiviral signaling. Belgnaoui et al. (2012) discover that linear ubiquitination of NEMO at a late phase of virus infection switches NEMO from a positive to a negative regulator of RIG-I-mediated interferon (IFN) induction by disrupting the VISA/MAVS-TRAF3 complex and thus terminating the antiviral response.
Wuhan Institute of Virology, State Key Laboratory of Virology, Chinese Academy of Sciences, China. wangyy@wh.iov.cn
Yan-Yi
YY
Wang
Yong
Y
Ran
Hong-Bing
HB
Shu