Mitochondria in relation to cancer metastasis.
Mitochondria, also known as "Power House of cell," are crucial organelles, regulating energy metabolism. Recently, an involvement of mitochondria in cancer occurrence and metastasis has been proposed. The roles of mitochondria in cancer progression/metastasis include alteration of glycolysis, regulation of ROS and suppression of intrinsic apoptosis. This mini-review explains the specific mitochondrial characteristics during cancer metastasis with past and recent findings. It may contribute to understanding mitochondria-related mechanisms of cancer metastasis.
Department of Pharmacology, School of Medicine, Chonbuk National University, Jeonju, Korea.
Bidur
B
Bhandary
Anu
A
Marahatta
Hyung-Ryong
HR
Kim
Han-Jung
HJ
Chae
D000818:Animals; D017209:Apoptosis; D004734:Energy Metabolism; D006801:Humans; D008928:Mitochondria / Q000378:metabolism* / Q000473:pathology; D009362:Neoplasm Metastasis; D009369:Neoplasms / Q000378:metabolism* / Q000473:pathology; D017382:Reactive Oxygen Species / Q000378:metabolism*
D017382:Reactive Oxygen Species