Genetic diversity and admixture patterns in Indian populations.
India is a diverse land whose population holds the history of waves of human dispersal. Recent studies suggest two major ancestral contributions to most of the Indian sub-populations. However, present day Indians are thought to contain huge genetic diversity derived consequent to multiple cultural, linguistic and geographical variations. Genome-wide survey of individuals from current North (N-In) and South (S-In) India along with populations from HapMap Phase III and Indian sub-populations from HUGO Pan-Asian SNP Consortium is performed. Multivariate analysis (MDS and PCA) was carried out after merging data from the current study and other consortia. Indian sub-populations clustered separately from populations of major global geographical regions in MDS and PCA in a loose agglomeration except for two Indian subpopulations clustering near far eastern populations. F(st) values indicated diversity among Indian sub-populations which was substantiated by STRUCTURE analysis suggesting the possibility of additional admixture events.
Philips Research Asia, Bangalore, Philips Innovation Campus, Manyata Tech Park, Nagavara, Bangalore, 560045, India.
Biswaroop
B
Chakrabarti
Sunil
S
Kumar
Randeep
R
Singh
Nevenka
N
Dimitrova
D005006:Ethnicity / Q000235:genetics*; D014644:Genetic Variation; D005828:Genetics, Population; D005843:Geography; D060148:HapMap Project; D006239:Haplotypes; D006801:Humans; D007194:India / Q000453:epidemiology; D010802:Phylogeny; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*