In search of a better understanding of IgA nephropathy-associated hematuria.
Although microscopic or episodic macroscopic hematuria is the key clinical manifestation of IgA nephropathy (IgAN), still very little is known about its pathogenesis. Cox et al. studied IgAN patients during episodes of macroscopic hematuria and identified an upregulated expression of the chemokine receptor CX3CR1 in their circulating leukocytes. On the basis of a series of additional experimental approaches, they suggest that CX3CR1 and its ligand fractalkine may contribute to the onset of macroscopic hematuria in IgAN.
Frank
F
Eitner
Jürgen
J
Floege
D000073883:CX3C Chemokine Receptor 1; D054428:Chemokine CX3CL1 / Q000378:metabolism*; D005260:Female; D005922:Glomerulonephritis, IGA / Q000276:immunology*; D006417:Hematuria / Q000276:immunology*; D006801:Humans; D007113:Immunity, Innate; D018928:Immunity, Mucosal; D007963:Leukocytes, Mononuclear / Q000276:immunology*; D008297:Male; D019707:Receptors, Chemokine / Q000378:metabolism*
D000073883:CX3C Chemokine Receptor 1; C515538:CX3CL1 protein, human; C095235:CX3CR1 protein, human; D054428:Chemokine CX3CL1; D019707:Receptors, Chemokine