The potential of flavanol and procyanidin intake to influence age-related vascular disease.
Advancing age is an independent major risk factor for cardiovascular disease (CVD). Age-associated impairments in the control of inflammation, excessive oxidative stress, and reduced cellular repair can all contribute to the development and progression of CVD. Current recommendations for both the primary and secondary prevention of CVD promote lifestyle modifications that include the adoption of healthy dietary patterns, such as the consumption of diets rich in plant foods, as these have been associated with a lower lifetime risk for the development of CVD. The potential for a diet rich in plant foods to be cardiovascular protective is also supported by prospective studies that suggest the intake of foods providing high amounts of certain phytochemicals, in particular flavanols and procyanidins, reduce the risk for CVD. These observations are further supported by a number of dietary intervention trials that show improvements in vascular function and reduced platelet reactivity following the consumption of high flavanol foods. In the current article we review a selection of these studies, and comment on some of the potential mechanisms that have been postulated to underlie the health effects of flavanol and procyanidin-rich foods.
Department of Nutrition, University of California, Davis, California 95616, USA.
Roberta R
RR
Holt
Christian
C
Heiss
Malte
M
Kelm
Carl L
CL
Keen
D000367:Age Factors; D001792:Blood Platelets / Q000187:drug effects / Q000502:physiology; D001808:Blood Vessels / Q000187:drug effects* / Q000502:physiology; D004032:Diet; D005419:Flavonoids / Q000494:pharmacology / Q000627:therapeutic use*; D006801:Humans; D008517:Phytotherapy; D010936:Plant Extracts / Q000494:pharmacology / Q000627:therapeutic use*; D044945:Proanthocyanidins / Q000494:pharmacology / Q000627:therapeutic use*; D014652:Vascular Diseases / Q000517:prevention & control*
D005419:Flavonoids; D010936:Plant Extracts; D044945:Proanthocyanidins