Protective effects of thymol on altered plasma lipid peroxidation and nonenzymic antioxidants in isoproterenol-induced myocardial infarcted rats.
This study evaluates the protective effects of thymol on altered plasma lipid peroxidation products and nonenzymic antioxidants in isoproterenol (ISO)-induced myocardial infarcted rats. Male albino Wistar rats were pre and cotreated with thymol (7.5 mg/kg body weight) daily for 7 days. ISO (100 mg/kg body weight) was subcutaneously injected into rats on 6th and 7th day to induce myocardial infarction (MI). Increased activity/levels of serum creatine kinase-MB (CK-MB), plasma thiobarbituric acid reactive substances, lipid hydroperoxides, and conjugated dienes with decreased levels of plasma reduced glutathione (GSH), vitamin C, and vitamin E were observed in ISO-induced myocardial infarcted rats. Pre and cotreatment with thymol (7.5 mg/kg body weight) showed normalized activity of serum CK-MB and near normalized levels of plasma lipid peroxidation products, reduced GSH, vitamin C, and vitamin E in myocardial infarcted rats. Furthermore, the in vitro study on reducing power of thymol confirmed its potent antioxidant action. Thus, thymol protects ISO-induced MI in rats by its antilipid peroxidation and antioxidant properties.
Department of Biochemistry and Biotechnology, Annamalai University, Annamalai Nagar 608 002, Tamil Nadu, India.
Mohamed Fizur Nagoor
MF
Meeran
Ponnian Stanely Mainzen
PS
Prince
D000818:Animals; D000975:Antioxidants / Q000378:metabolism*; D002316:Cardiotonic Agents / Q000494:pharmacology* / Q000627:therapeutic use; D052279:Creatine Kinase, MB Form / Q000097:blood; D004305:Dose-Response Relationship, Drug; D005978:Glutathione / Q000097:blood; D007545:Isoproterenol; D015227:Lipid Peroxidation; D008297:Male; D009203:Myocardial Infarction / Q000097:blood / Q000139:chemically induced / Q000188:drug therapy*; D051381:Rats; D017208:Rats, Wistar; D019163:Reducing Agents / Q000494:pharmacology / Q000627:therapeutic use; D017392:Thiobarbituric Acid Reactive Substances / Q000378:metabolism; D013943:Thymol / Q000494:pharmacology* / Q000627:therapeutic use
D000975:Antioxidants; D002316:Cardiotonic Agents; D019163:Reducing Agents; D017392:Thiobarbituric Acid Reactive Substances; D013943:Thymol; D052279:Creatine Kinase, MB Form; D005978:Glutathione; D007545:Isoproterenol