Axially chiral triazoloisoquinolin-3-ylidene ligands in gold(I)-catalyzed asymmetric intermolecular (4 + 2) cycloadditions of allenamides and dienes.
The first highly enantioselective intermolecular (4 + 2) cycloaddition between allenes and dienes is reported. The reaction provides good yields of optically active cyclohexenes featuring diverse substitution patterns and up to three stereocenters. Key to the success of the process is the use of newly designed axially chiral N-heterocyclic carbene-gold catalysts.
Centro Singular de Investigación en Química Biolóxica e Materiais Moleculares and Departamento de Química Orgánica, Unidad Asociada al CSIC, Universidad de Santiago de Compostela, 15782, Santiago de Compostela, Spain.
Javier
J
Francos
Francisca
F
Grande-Carmona
Hélio
H
Faustino
Javier
J
Iglesias-Sigüenza
Elena
E
Díez
Isaac
I
Alonso
Rosario
R
Fernández
José M
JM
Lassaletta
Fernando
F
López
José L
JL
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