Acute liver failure following minocycline treatment - a case report and review of the literature.
We present the case of a 23-year-old female patient with acute liver failure following intake of minocycline. This patient had severe hypereosinophilia and massively increased IgE levels. Experimental studies in this case revealed elevated IFN-γ-, as well as TNF-α-producing CD4+ and CD8+ T-cells after in vitro stimulation with minocycline, indicating a type I/IgE-mediated as well as type II/cytotoxic reaction in the pathogenesis of minocycline-induced liver failure. Although mild forms of liver involvement are well known side effects of minocycline, only 8 cases with acute liver failure have been reported, and we present a review of all cases.
Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
A
A
Kuhn
C
C
Weiler-Normann
C
C
Schramm
S
S
Kluge
M J
MJ
Behne
A W
AW
Lohse
D
D
Benten
D000900:Anti-Bacterial Agents / Q000009:adverse effects; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D017114:Liver Failure, Acute / Q000139:chemically induced* / Q000175:diagnosis / Q000517:prevention & control*; D008911:Minocycline / Q000009:adverse effects*; D055815:Young Adult
D000900:Anti-Bacterial Agents; D008911:Minocycline