The relationship between mean platelet volume and fasting plasma glucose differs with glucose tolerance status in a Korean general population: gender differences.
Mean platelet volume (MPV), which is used to measure platelet size, can reflect platelet activity. The objective of the present study was to evaluate the relationship between MPV and fasting plasma glucose (FPG) according to glucose tolerance (GT) status in a general population. We retrospectively studied 3098 Korean adults who underwent voluntary regular health check-ups at the Health Promotion Center of our hospital from January 2009 to December 2011. MPV was analysed within 2 hours of blood collection. A multiple linear regression analysis indicated that MPV had a significant negative correlation with FPG when the confounding variables of normal glucose tolerance (β ± SE, -0.112 ± 0.033, R(2), 0.109, men; -0.102 ± 0.034, 0.132, women) and intermediate hyperglycemia (-0.072 ± 0.027, 0.130, men; -0.111 ± 0.035, 0.100, women) were adjusted for. However, MPV had a significant positive relationship with FPG after adjusting for diabetes in women as a confounding factor (0.097 ± 0.037, 0.442). We observed a contrasting relationship between MPV and FPG in the presence and absence of diabetes. This result suggests that the positive relationship between an increased glucose level and increased MPV is a unique phenomenon of diabetes itself. To our knowledge, this is the first study to demonstrate a different relationship between MPV and FPG according to glucose tolerance status in a general population.
Department of Endocrinology and Metabolism, Chosun University Hospital, Gwangju, Republic of Korea.
Jin Hwa
JH
Kim
Seung Bum
SB
Kang
Ji In
JI
Kang
Jin Woo
JW
Kim
Sang Yong
SY
Kim
Hak Yeon
HY
Bae
D000328:Adult; D044466:Asian People; D001786:Blood Glucose; D005215:Fasting / Q000502:physiology*; D005260:Female; D005951:Glucose Tolerance Test; D006801:Humans; D008297:Male; D063847:Mean Platelet Volume; D008875:Middle Aged; D011159:Population Surveillance; D056910:Republic of Korea; D012189:Retrospective Studies; D012737:Sex Factors
D001786:Blood Glucose