MCM structure and mechanics: what we have learned from archaeal MCM.
Minichromosome maintenance (MCM) complexes have been identified as the primary replicative helicases responsible for unwinding DNA for genome replication. The focus of this chapter is to discuss the current structural and functional understanding of MCMs and their role at origins of replication, which are based mostly on the studies of MCM proteins and MCM complexes from archaeal genomes.
Molecular and Computational Biology, University of Southern California, Los Angeles, CA, 90089, USA.
Ian M
IM
Slaymaker
Xiaojiang S
XS
Chen
D001105:Archaea / Q000502:physiology*; D019843:Archaeal Proteins / Q000235:genetics / Q000378:metabolism*; D004261:DNA Replication / Q000502:physiology*; D019641:DNA, Archaeal / Q000096:biosynthesis* / Q000235:genetics; D020745:Genome, Archaeal / Q000502:physiology*; D064110:Minichromosome Maintenance Proteins / Q000235:genetics / Q000378:metabolism*
D019843:Archaeal Proteins; D019641:DNA, Archaeal; D064110:Minichromosome Maintenance Proteins