Fetal links to chronic disease: the role of gestational diabetes mellitus.
A growing body of literature suggests that chronic disease has much of its origins in the fetal response to the intrauterine environment, a concept known as "fetal programming." Longitudinal studies have demonstrated that higher rates of obesity, impaired glucose tolerance, hypertension, and dyslipidemia are evident in the offspring of diabetic women. This review focuses on the implications of intrauterine exposure to an altered maternal metabolic milieu and the risk of childhood obesity and metabolic dysfunction.
Department of Obstetrics and Gynecology, The University of Pennsylvania, PA, USA. celeste.durnwald@uphs.upenn.edu
Celeste
C
Durnwald
Mark
M
Landon
D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D016640:Diabetes, Gestational / Q000453:epidemiology*; D050171:Dyslipidemias / Q000453:epidemiology; D005260:Female; D047109:Fetal Development; D018149:Glucose Intolerance / Q000453:epidemiology*; D006801:Humans; D006973:Hypertension / Q000453:epidemiology; D008137:Longitudinal Studies; D009765:Obesity / Q000453:epidemiology*; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects / Q000453:epidemiology*