Macrophage migration inhibitory factor: a potential marker for cancer diagnosis and therapy.
Macrophage migration inhibitory factor (MIF) is a pluripotent cytokine which plays roles in inflammation, immune responses and cancer development. It assists macrophages in carrying out functions like phagocytosis, adherence and motility. Of late, MIF is implicated in almost all stages of neoplasia and expression is a feature of most types of cancer. The presence of MIF in almost all tumors and all stages of cancer makes it an interesting candidate for cancer therapy. This review explores the roles of MIF in neoplasia.
IGNOU-I2IT Centre of Excellence for Advanced Education and Research, Pune, Maharashtra, India.
Spoorthy N
SN
Babu
Gaurav
G
Chetal
Sudhir
S
Kumar
D014408:Biomarkers, Tumor / Q000378:metabolism*; D006801:Humans; D008263:Macrophage Migration-Inhibitory Factors / Q000378:metabolism*; D008264:Macrophages / Q000166:cytology / Q000378:metabolism*; D009369:Neoplasms / Q000175:diagnosis* / Q000378:metabolism / Q000628:therapy*
D014408:Biomarkers, Tumor; D008263:Macrophage Migration-Inhibitory Factors