Gold nanoparticles elevate plasma testosterone levels in male mice without affecting fertility.
ω-Methoxy and ω-aminoethyl poly(ethylene glycol)-modified 14-nm gold nanoparticles can accumulate in mouse testes, pass through the blood-testis barrier, and enter germ cells. Furthermore, PEG-NH2 @AuNP accumulate more easier in the testes and increase plasma T levels. However, these two gold nanoparticle types have no effect on male fertility, fetal survival, or fetal development.
Hefei National Laboratory for Physical Sciences at the Microscale and School of Life Sciences, University of Science and Technology of China, Hefei, Anhui 230027, PR China.
Wen-Qing
WQ
Li
Feng
F
Wang
Zhi-Min
ZM
Liu
Yu-Cai
YC
Wang
Jun
J
Wang
Fei
F
Sun
D000818:Animals; D005298:Fertility; D006046:Gold / Q000737:chemistry*; D008297:Male; D053768:Metal Nanoparticles; D051379:Mice; D008813:Mice, Inbred ICR; D046529:Microscopy, Electron, Transmission; D013739:Testosterone / Q000097:blood*
D013739:Testosterone; D006046:Gold