Light-activated ruthenium complexes photobind DNA and are cytotoxic in the photodynamic therapy window.
Incorporation of biquinoline ligands into Ru(II) polypyridyl complexes produces light-activated systems that eject a ligand and photobind DNA after irradiation with visible and near-IR light. Structural analysis shows that distortion facilitates the photochemistry, and gel shift and cytotoxicity studies prove the compounds act as anti-cancer photodynamic therapy (PDT) agents in the tissue penetrant region.
Department of Chemistry, University of Kentucky, Lexington, KY 40506, USA.
Erin
E
Wachter
David K
DK
Heidary
Brock S
BS
Howerton
Sean
S
Parkin
Edith C
EC
Glazer
D000970:Antineoplastic Agents / Q000737:chemistry / Q000494:pharmacology*; D049109:Cell Proliferation / Q000187:drug effects; D004247:DNA / Q000737:chemistry*; D004249:DNA Damage; D004305:Dose-Response Relationship, Drug; D004354:Drug Screening Assays, Antitumor; D018922:HL-60 Cells; D006801:Humans; D008027:Light; D008958:Models, Molecular; D015394:Molecular Structure; D009942:Organometallic Compounds / Q000737:chemistry / Q000494:pharmacology*; D055668:Photochemical Processes; D010778:Photochemotherapy; D011725:Pyridines / Q000737:chemistry; D011804:Quinolines / Q000737:chemistry; D012428:Ruthenium / Q000737:chemistry*; D013329:Structure-Activity Relationship
D000970:Antineoplastic Agents; D009942:Organometallic Compounds; D011725:Pyridines; D011804:Quinolines; D012428:Ruthenium; D004247:DNA