Microwave assisted synthesis of amorphous magnesium phosphate nanospheres.
Magnesium phosphate (MgP) materials have been investigated in recent years for tissue engineering applications, attributed to their biocompatibility and biodegradability. This paper describes a novel microwave assisted approach to produce amorphous magnesium phosphate (AMP) in a nanospherical form from an aqueous solution containing Mg(2+) and HPO(4)                           (2-)/PO(4)                           (3-). Some synthesis parameters such as pH, Mg/P ratio, solution composition were studied and the mechanism of AMP precursors was also demonstrated. The as-produced AMP nanospheres were characterized and tested in vitro. The results proved these AMP nanospheres can self-assemble into mature MgP materials and support cell proliferation. It is expected such AMP has potential in biomedical applications.
Department of Mechanical, Industrial and Manufacturing Engineering, University of Toledo, Toledo, OH, USA. Huan.Zhou@rockets.utoledo.edu
Huan
H
Zhou
Timothy J F
TJ
Luchini
Sarit B
SB
Bhaduri
D000818:Animals; D001672:Biocompatible Materials / Q000737:chemistry*; D001842:Bone and Bones / Q000378:metabolism; D002118:Calcium / Q000737:chemistry; D002460:Cell Line; D049109:Cell Proliferation; D007700:Kinetics; D008274:Magnesium / Q000737:chemistry; D017616:Magnesium Compounds / Q000737:chemistry*; D008422:Materials Testing; D051379:Mice; D008855:Microscopy, Electron, Scanning / Q000379:methods; D046529:Microscopy, Electron, Transmission / Q000379:methods; D008872:Microwaves; D054118:Nanospheres / Q000737:chemistry*; D036103:Nanotechnology / Q000379:methods; D010006:Osteoblasts / Q000166:cytology; D010710:Phosphates / Q000737:chemistry*; D023822:Tissue Engineering / Q000379:methods; D014961:X-Ray Diffraction
D001672:Biocompatible Materials; D017616:Magnesium Compounds; D010710:Phosphates; C030781:magnesium phosphate; D008274:Magnesium; D002118:Calcium