Severe hemolytic transfusion reaction due to anti-A1 following allogeneic stem cell transplantation with minor ABO incompatibility.
Blood components should be compatible both with the recipient and the donor in the ABO incompatible allogeneic stem cell transplantation setting. A patient with blood type A2 received peripheral blood stem cells from a blood type O donor. The patient was in critical condition due to treatment-related toxicity. He had acquired anti-A1 that was unfortunately overlooked. Following transfusion of A1 red blood cells in error, he developed a severe hemolytic transfusion reaction. Anti-A1 is rarely clinically significant. We discuss the role of passenger lymphocytes in development of the anti-A1, and stress the importance of investigating unusual/atypical reactions in blood typing.
Department of Immunology and Transfusion Medicine, Oslo University Hospital, Ullevaal, N-0407 Oslo, Norway. cigdemakak@yahoo.no
Ciğdem Akalın
CA
Akkök
Håkon
H
Haugaa
Anders
A
Galgerud
Lorentz
L
Brinch
D000743:Anemia, Hemolytic / Q000097:blood / Q000209:etiology / Q000276:immunology*; D001787:Blood Group Incompatibility / Q000276:immunology*; D006461:Hemolysis / Q000276:immunology; D006801:Humans; D008297:Male; D008875:Middle Aged; D033581:Stem Cell Transplantation / Q000379:methods*; D014184:Transplantation, Homologous / Q000379:methods