ER stress and autophagy contribute to CsA-induced death of malignant glioma cells.
Cyclosporine A (CsA), which revolutionized transplantology due to its ability to block the activation of lymphocytes and other immune system cells, triggers autophagy in malignant glioma cell lines via stimulation of endoplasmic reticulum (ER) stress. We also found that autophagy serves as a protective mechanism against CsA toxicity.
Laboratory of Transcription Regulation, Department of Cell Biology, Nencki Institute of Experimental Biology, Warsaw, Poland. jcjech@nencki.gov.pl
Iwona Anna
IA
Ciechomska
Bozena
B
Kaminska
D000818:Animals; D001343:Autophagy / Q000187:drug effects*; D045744:Cell Line, Tumor; D016572:Cyclosporine / Q000494:pharmacology* / Q000627:therapeutic use; D019008:Drug Resistance, Neoplasm / Q000187:drug effects; D059865:Endoplasmic Reticulum Stress / Q000187:drug effects*; D005910:Glioma / Q000188:drug therapy / Q000473:pathology*; D006801:Humans; D008954:Models, Biological; D051381:Rats
D016572:Cyclosporine