What T cells see in WT-1.
The Wilms tumor protein, WT-1, is a widely recognized tumor antigen that is aberrantly expressed in myeloid and lymphoid leukemia and in this issue of Blood, Doubrovina et al report the most extensive catalog heretofore of HLA-restricted immunogenic peptides derived from WT-1, which are recognized by CD8 and CD4T cells.
MD Anderson Cancer Center, USA.
Jeffrey J
JJ
Molldrem
D018984:Epitopes, T-Lymphocyte / Q000276:immunology*; D006680:HLA Antigens / Q000276:immunology*; D006801:Humans; D007938:Leukemia / Q000276:immunology*; D010455:Peptides / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology*; D025721:WT1 Proteins / Q000276:immunology*
D018984:Epitopes, T-Lymphocyte; D006680:HLA Antigens; D010455:Peptides; D025721:WT1 Proteins