Association study of ACE and eNOS single nucleotide polymorphisms with             Henoch-Schönlein purpura nephritis.
Previous studies have shown that insertion/deletion polymorphisms in the             angiotensin-converting enzyme (ACE) gene and the endothelial nitric oxide synthase             (eNOS) gene are associated with Henoch-Schönlein purpura nephritis (HSPN). However,             further studies are required to prove the relationship between HSPN and ACE and             eNOS single nucleotide polymorphisms (SNPs). We studied six ACE SNPs and two eNOS             SNPs by genotyping HSPN patients. Statistical analyses indicate that four ACE             SNPs and two eNOS SNPs are associated with HSPN susceptibility. A cumulative effect             analysis suggested that an increased number of unfavourable genotypes may lead             to an increased risk of HSPN. By comparing alleles, genotypes and haplotypes that             are associated with lupus nephritis (LN) and HSPN, we found genetic heterogeneity             between HSPN and LN.
The First Affiliated Hospital, Harbin Medical University, Harbin, Heilongjiang 150080, PR China.
Bo
B
Di
Xinyuan
X
Li
Liqun
L
Song
Qianghu
Q
Wang
Suyan
S
Liu
D000483:Alleles; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D006239:Haplotypes; D006801:Humans; D011695:IgA Vasculitis / Q000235:genetics*; D008181:Lupus Nephritis / Q000235:genetics; D008297:Male; D052250:Nitric Oxide Synthase Type III / Q000235:genetics*; D007703:Peptidyl-Dipeptidase A / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide
C496314:NOS3 protein, human; D052250:Nitric Oxide Synthase Type III; D007703:Peptidyl-Dipeptidase A