Waking up the sleepers: shared transcriptional pathways in axonal regeneration and neurogenesis.
In the last several years, relevant progress has been made in our understanding of the transcriptional machinery regulating CNS repair after acute injury, such as following trauma or stroke. In order to survive and functionally reconnect to the synaptic network, injured neurons activate an intrinsic rescue program aimed to increase their plasticity. Perhaps, in the attempt to switch back to a plastic and growth-competent state, post-mitotic neurons wake up and re-express a set of transcription factors that are also critical for the regulation of their younger brothers, the neural stem cells. Here, we review and discuss the transcriptional pathways regulating both axonal regeneration and neurogenesis highlighting the connection between the two. Clarification of their common molecular substrate may help simultaneous targeting of both neurogenesis and axonal regeneration with the hope to enhance functional recovery following CNS injury.
Laboratory for NeuroRegeneration and Repair, Center for Neurology, Hertie Institute for Clinical Brain Research, University of Tuebingen, Otfried-Mueller Strasse 27, 72076, Tuebingen, Germany. giorgia.quadrato@medizin.uni-tuebingen.de
Giorgia
G
Quadrato
Simone
S
Di Giovanni
D000818:Animals; D001369:Axons / Q000502:physiology*; D002490:Central Nervous System / Q000166:cytology* / Q000293:injuries; D005786:Gene Expression Regulation / Q000502:physiology*; D006801:Humans; D008322:Mammals / Q000502:physiology*; D008954:Models, Biological; D009416:Nerve Regeneration / Q000502:physiology*; D055495:Neurogenesis / Q000502:physiology*; D009473:Neuronal Plasticity / Q000502:physiology*; D014157:Transcription Factors / Q000378:metabolism*
D014157:Transcription Factors