A potential water-soluble ytterbium-based porphyrin-cyclen dual bio-probe for Golgi apparatus imaging and photodynamic therapy.
An amphiphilic water-soluble ytterbium complex which is photo-selective, functional and Golgi apparatus specific has been designed as a responsive dual probe capable of sensitizing emission within the biological window (660 and 750 nm), generating the singlet oxygen (Φ(Δ) = 0.45) and triggering local cell damage only upon exposure to visible and near-infrared laser excitation.
Department of Chemistry, Hong Kong Baptist University, Kowloon Tong, Hong Kong SAR, P. R. China. zhangjx_hk@hotmail.com
Jing-Xiang
JX
Zhang
Hongguang
H
Li
Chi-Fai
CF
Chan
Rongfeng
R
Lan
Wai-Lun
WL
Chan
Ga-Lai
GL
Law
Wai-Kwok
WK
Wong
Ka-Leung
KL
Wong
D000970:Antineoplastic Agents / Q000737:chemistry* / Q000494:pharmacology; D015374:Biosensing Techniques; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D000080027:Cyclams; D004305:Dose-Response Relationship, Drug; D004354:Drug Screening Assays, Antitumor; D006056:Golgi Apparatus / Q000648:ultrastructure*; D006367:HeLa Cells; D006571:Heterocyclic Compounds / Q000737:chemistry; D006801:Humans; D009942:Organometallic Compounds / Q000737:chemistry* / Q000494:pharmacology; D010778:Photochemotherapy; D011166:Porphyrins / Q000737:chemistry; D012995:Solubility; D013329:Structure-Activity Relationship; D014867:Water / Q000737:chemistry; D015018:Ytterbium / Q000737:chemistry
D000970:Antineoplastic Agents; D000080027:Cyclams; D006571:Heterocyclic Compounds; D009942:Organometallic Compounds; D011166:Porphyrins; D014867:Water; C038072:cyclen; D015018:Ytterbium