Simultaneous determination of triclosan, triclocarban, and transformation products of triclocarban in aqueous samples using solid-phase micro-extraction-HPLC-MS/MS.
The presence of triclosan and triclocarban, two endocrine-disrupting chemicals and antimicrobial agents, and transformation products of triclocarban, 1,3-di(phenyl)urea, 1,3-bis(4-chlorophenyl)urea and 1,3-bis(3,4-dichlorophenyl)urea, in tap water, treated household drinking water, bottled water, and river water samples were investigated using solid-phase micro-extraction coupled with-HPLC-MS/MS, a rapid, green, and sensitive method. Factors influencing the quantity of the analytes extracted onto the solid-phase micro-extraction fiber, such as addition of salt, sample pH, extraction time, desorption time, and sample volume, were optimized using solid-phase micro-extraction-HPLC-MS/MS. The results showed that the method gave satisfactory sensitivities and precisions for analyzing sub-part-per-trillion levels of triclosan, triclocarban, and transformation products of triclocarban in samples collected locally. The recoveries of analytes ranged from 97 to 107% for deionized water samples, and 99 to 110% for river water samples, and limits of detection were in the range of 0.32-3.44 and 0.38-4.67 ng/L for deionized water and river water samples, respectively. On average, the daily consumption of triclosan and triclocarban by an adult by consuming 2 liters of different types of drinking water were estimated to be in the range of 6.13-425 ng/day as a result of the concentrations of triclosan and triclocarban measured in this study.
Department of Chemistry, National Taiwan Normal University, Taipei, Taiwan.
Jermiah Y
JY
Shen
Matt S
MS
Chang
Sheng-Hsiung
SH
Yang
Gaston J
GJ
Wu
D000890:Anti-Infective Agents / Q000737:chemistry* / Q000302:isolation & purification; D002224:Carbanilides / Q000737:chemistry* / Q000302:isolation & purification; D002851:Chromatography, High Pressure Liquid / Q000379:methods*; D052617:Solid Phase Microextraction / Q000379:methods*; D053719:Tandem Mass Spectrometry / Q000379:methods*; D014260:Triclosan / Q000737:chemistry* / Q000302:isolation & purification; D014874:Water Pollutants, Chemical / Q000737:chemistry* / Q000302:isolation & purification
D000890:Anti-Infective Agents; D002224:Carbanilides; D014874:Water Pollutants, Chemical; D014260:Triclosan; C009540:triclocarban