Association between body mass index, lipid profiles, and types of urinary stones.
OBJECTIVE
The purpose of this study was to determine the differences in body mass index (BMI), levels of cholesterol, and levels of triglycerides (TGs) among urolithiasis patients with different stone compositions.


METHODS
Forty-nine patients who had a diagnosis of nephrolithiasis and had undergone open surgery or percutaneous surgery were included, and patients without urolithiasis were randomly selected as controls. Urinary stones were collected and analyzed using infrared spectroscopy. Data relating to patient's age, BMI at diagnosis, serum total cholesterol (TC), high-density lipoprotein cholesterol, and low-density lipoprotein cholesterol (LDL-C) were collected. The stone groups including calcium oxalate monohydrate-calcium oxalate dihydrate (COM-COD), COM, and uric acid were compared with one another and with the control group. In addition, the stone formers group (COM-COD, COM, uric acid, calcium phosphate, and mixed-type stones) was compared to the control group.


RESULTS
BMI, TC, and TG levels were significantly higher in stone formers compared with the control group; this association of BMI and TC with stone formation was more prominent in uric acid and COM-COD stone formers, but there was no such prominence for COM stones. LDL-C levels in COM-COD stone formers were significantly higher when compared with COM stone formers.


CONCLUSIONS
Elevated BMI, hypercholesterolemia, and hyperlipidemia, which are leading components of metabolic syndrome, may be associated with different types of urinary stone formation.
Department of Urology, Mustafa Kemal University School of Medicine, Antakya, Turkey. mehmetinci@gmail.com
Mehmet
M
Inci
Abdullah
A
Demirtas
Bahadir
B
Sarli
Emrecan
E
Akinsal
Numan
N
Baydilli
D000328:Adult; D015992:Body Mass Index; D002129:Calcium Oxalate / Q000032:analysis*; D002130:Calcium Phosphates / Q000032:analysis*; D018450:Disease Progression; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008055:Lipids / Q000097:blood*; D008297:Male; D024821:Metabolic Syndrome / Q000097:blood / Q000150:complications*; D008875:Middle Aged; D012189:Retrospective Studies; D014545:Urinary Calculi / Q000737:chemistry* / Q000209:etiology / Q000378:metabolism
D002130:Calcium Phosphates; D008055:Lipids; D002129:Calcium Oxalate; C020243:calcium phosphate