Meta-analysis of the methylenetetrahydrofolate reductase C677T polymorphism and susceptibility to pre-eclampsia.
A number of studies have investigated the association between the methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism and the risk of pre-eclampsia (PE) in various populations and have delivered inconsistent results. Therefore, this meta-analysis of 36 case-control studies, comprising 4253 PE cases and 4950 controls, were assessed to evaluate a possible association. The pooled results showed that the MTHFR C677T polymorphism was significantly associated with PE (P=0.03, odds ratio (OR)=1.25, 95% confidence interval (CI)=1.02-1.54, for the additive comparison; P=0.04, OR=1.14, 95% CI=1.01-1.29, for the dominant genetic model). The results of the subgroup analysis showed that MTHFR 677T had the effect of increasing the PE risk for the recessive genetic model (P<0.0001, OR=1.76, 95% CI=1.33-2.33, P(heterogeneity)=0.28), the additive comparison (P=0.002, OR=2.09, 95% CI=1.31-3.31, P(heterogeneity)=0.08) and allele contrasts (P=0.03, OR=1.42, 95% CI=1.04-1.95, P(heterogeneity)=0.0001) in the Asians, while no evidence of an association between MTHFR C677T polymorphisms and PE was observed in the Caucasians. This meta-analysis suggests that the MTHFR C677T polymorphism is capable of causing PE susceptibility in the Asians but not in the Caucasians.
Department of Gynecology and Obstetrics, the First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China.
Xiao-ping
XP
Xia
Wei-wei
WW
Chang
Yun-xia
YX
Cao
D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D042965:Methylenetetrahydrofolate Reductase (NADPH2) / Q000235:genetics*; D011110:Polymorphism, Genetic; D011225:Pre-Eclampsia / Q000209:etiology / Q000235:genetics*; D011247:Pregnancy; D017594:Publication Bias
D042965:Methylenetetrahydrofolate Reductase (NADPH2)