neo-Clerodane diterpenes from Ajuga decumbens and their inhibitory activities on LPS-induced NO production.
A phytochemical investigation of the whole plants of Ajuga decumbens led to the isolation of three new (1, 2a, and 2b) and three known (3a-3c) neo-clerodane diterpenes. Their structures were elucidated by spectroscopic data analysis (IR, ESIMS, HR-ESIMS, 1D and 2D NMR), and the structure of 1 was confirmed by X-ray crystallography. The inhibitory activities on LPS-induced NO production of the six diterpenes were evaluated and compounds 2a, 2b, and 3a showed inhibitory effects.
College of Pharmacy, State Key Laboratory of Medicinal Chemical Biology and Tianjin Key Laboratory of Molecular Drug Research, Nankai University, Tianjin 300071, China.
Zhanping
Z
Sun
Yushan
Y
Li
Da-qing
DQ
Jin
Ping
P
Guo
Haibin
H
Song
Jing
J
Xu
Yuanqiang
Y
Guo
Lei
L
Zhang
D031328:Ajuga / Q000737:chemistry*; D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000494:pharmacology*; D002460:Cell Line; D045785:Diterpenes, Clerodane / Q000737:chemistry* / Q000145:classification* / Q000494:pharmacology; D008070:Lipopolysaccharides / Q000633:toxicity*; D051379:Mice; D017628:Microglia / Q000187:drug effects / Q000378:metabolism; D015394:Molecular Structure; D009569:Nitric Oxide / Q000378:metabolism*
D000972:Antineoplastic Agents, Phytogenic; D045785:Diterpenes, Clerodane; D008070:Lipopolysaccharides; D009569:Nitric Oxide