C-type lectin receptors orchestrate antifungal immunity.
Immunity to pathogens critically requires pattern-recognition receptors (PRRs) to trigger intracellular signaling cascades that initiate and direct innate and adaptive immune responses. For fungal infections, these responses are primarily mediated by members of the C-type lectin receptor family. In this Review, we highlight recent advances in the understanding of the roles and mechanisms of these multifunctional receptors, explore how these PRRs orchestrate antifungal immunity and briefly discuss progress in the use of these receptors as targets for antifungal and other vaccines.
Aberdeen Fungal Group, Section of Immunology and Infection, University of Aberdeen, Aberdeen, UK.
Sarah E
SE
Hardison
Gordon D
GD
Brown
D000818:Animals; D005657:Fungal Vaccines / Q000276:immunology; D005658:Fungi / Q000276:immunology*; D006801:Humans; D037181:Lectins, C-Type / Q000276:immunology*; D009181:Mycoses / Q000276:immunology; D051192:Receptors, Pattern Recognition / Q000276:immunology; D015398:Signal Transduction / Q000276:immunology*
D005657:Fungal Vaccines; D037181:Lectins, C-Type; D051192:Receptors, Pattern Recognition