A rare case of intracerebral hemorrhage complicating heparin-induced thrombocytopenia with thrombosis: a clinical dilemma ameliorated by novel use of plasmapheresis.
We report a case of heparin-induced thrombocytopenia with thrombosis type 2 (HITT 2) that was first complicated by intracerebral hemorrhage (ICH) and later by deep venous thrombosis (DVT). HITT 2 was initially managed conventionally with argatroban, which was stopped when ICH was discovered. The size of ICH increased despite attempts to increase platelet count by platelet transfusions. At this point of the clinical dilemma, plasma exchange was utilized effectively to recover the platelet count and deter ICH progression. The clinical course was later complicated by DVT, for which fondaparinux was given. This case represents a rare clinical scenario of HITT 2 resulting in progressive ICH that excluded the use of antithrombotic agents as part of HITT therapy. We believe that the use of plasmapheresis as a salvage procedure in such situations is effective and life-saving. Physicians should be aware of plasmapheresis as a therapeutic option in HITT 2 in cases in which anticoagulation is contraindicated.
Division of Hematology and Oncology, The Brooklyn Hospital Center, 121 Dekalb Avenue, Brooklyn, NY 11201, USA. htunnm@gmail.com
Nay Min
NM
Tun
Zaw Min
ZM
Bo
Meena
M
Ahluwalia
Elizabeth
E
Guevara
Gina M
GM
Villani
D000368:Aged; D002543:Cerebral Hemorrhage / Q000150:complications* / Q000628:therapy*; D005338:Fibrin Fibrinogen Degradation Products; D005340:Fibrinogen; D006493:Heparin / Q000009:adverse effects*; D006801:Humans; D008297:Male; D010956:Plasmapheresis; D010976:Platelet Count; D013921:Thrombocytopenia / Q000139:chemically induced* / Q000150:complications*; D013927:Thrombosis / Q000150:complications*; D020246:Venous Thrombosis / Q000150:complications
D005338:Fibrin Fibrinogen Degradation Products; C036309:fibrin fragment D; D005340:Fibrinogen; D006493:Heparin