Peroxidasin: tying the collagen-sulfilimine knot.
Type IV collagen, a major constituent of basement membranes, contains an unusual intermolecular sulfilimine crosslink whose route of biosynthesis has remained undefined. An oxidative triad consisting of peroxidasin, H(2)O(2) and halide is now shown to drive sulfilimine generation in vivo.
Division of Molecular Medicine and Genetics, Department of Internal Medicine, University of Michigan, Ann Arbor, MI, USA. sjweiss@umich.edu
Stephen J
SJ
Weiss
D000818:Animals; D024141:Collagen Type IV / Q000378:metabolism*; D004330:Drosophila; D016326:Extracellular Matrix Proteins / Q000378:metabolism*; D007097:Imines / Q000378:metabolism*; D010084:Oxidation-Reduction; D009195:Peroxidase / Q000378:metabolism*; D000097423:Peroxidasin
D024141:Collagen Type IV; D016326:Extracellular Matrix Proteins; D007097:Imines; D009195:Peroxidase; D000097423:Peroxidasin