Pathological femoral fractures due to osteomalacia associated with adefovir dipivoxil treatment for hepatitis B: a case report.
We present a case of a 62-year-old man who underwent total hip arthroplasty for treatment of pathologic femoral neck fracture associated with adefovir dipivoxil-induced osteomalacia. He had a 13-month history of bone pain involving his shoulders, hips, and knee. He received adefovir dipivoxil for treatment of lamivudine-resistant hepatitis B virus infection for 5 years before the occurrence of femoral neck fracture. Orthopedic surgeons should be aware of osteomalacia and pathological hip fracture caused by drug-induced renal dysfunction, which results in Fanconi's syndrome.
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Department of Orthopaedic Surgery, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima, Japan.
Motoyuki
M
Tanaka
Takao
T
Setoguchi
Yasuhiro
Y
Ishidou
Yoshiya
Y
Arishima
Masataka
M
Hirotsu
Yoshinobu
Y
Saitoh
Shunsuke
S
Nakamura
Hironori
H
Kakoi
Satoshi
S
Nagano
Masahiro
M
Yokouchi
Junichi
J
Kamizono
Setsuro
S
Komiya
D000225:Adenine / Q000009:adverse effects / Q000031:analogs & derivatives*; D000998:Antiviral Agents / Q000009:adverse effects*; D019644:Arthroplasty, Replacement, Hip; D005198:Fanconi Syndrome / Q000139:chemically induced*; D005265:Femoral Neck Fractures / Q000139:chemically induced* / Q000000981:diagnostic imaging / Q000601:surgery; D019694:Hepatitis B, Chronic / Q000175:diagnosis / Q000188:drug therapy*; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D063065:Organophosphonates / Q000009:adverse effects*; D010018:Osteomalacia / Q000139:chemically induced*; D011237:Predictive Value of Tests; D011859:Radiography; D019275:Radiopharmaceuticals; D016896:Treatment Outcome; D051598:Whole Body Imaging
D000998:Antiviral Agents; D063065:Organophosphonates; D019275:Radiopharmaceuticals; D000225:Adenine; C106812:adefovir dipivoxil