The linkage disequilibrium pattern of the angiotensin converting enzyme gene in Arabic and Asian population groups.
BACKGROUND
DNA variations within the Angiotensin-Converting Enzyme (ACE) gene have been shown to be involved in the aetiology of several common diseases and the therapeutic response.


METHODS
This study reports a comparison of haplotype analysis of five SNPs in the ACE gene region using a sample of 100 healthy subjects derived from five different populations (Tunisian, Iranian, Kuwaiti, Bahraini and Indian).


RESULTS
Strong linkage disequilibrium was found among all SNPs studied for all populations. Two SNPs (rs1800764 and rs4340) were identified as key SNPs for all populations.


CONCLUSIONS
These SNPs will be valuable for future effective association studies of the ACE gene polymorphisms in Arab and Asian populations.
Centre de Biotechnologie de Sfax, University of Sfax, Biomolecular Screening Processes and Research Group, Sfax, Tunisia. najla.kharrat@cbs.rnrt.tn
Najla
N
Kharrat
Wafa
W
Abdelmouleh
Rania
R
Abdelhedi
Suad
S
Alfadhli
Ahmed
A
Rebai
D000483:Alleles; D044466:Asian People / Q000235:genetics*; D001445:Bahrain; D005260:Female; D005787:Gene Frequency; D014644:Genetic Variation; D006239:Haplotypes; D006801:Humans; D007194:India; D007492:Iran; D007730:Kuwait; D015810:Linkage Disequilibrium; D008297:Male; D007703:Peptidyl-Dipeptidase A / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D014416:Tunisia
D007703:Peptidyl-Dipeptidase A