[Centrilobular nodules with ground-glass opacities in the lungs].
We report the case of a 56 year-old Gabonese man under treatment by candesartan-hydrochlorothiazide for essential hypertension. After 2 months of treatment, he presented with pneumonia and severe respiratory failure. The chest radiography showed centrilobular nodules resembling tumor metastases, but no evidence of a primary tumor. Laboratory and imaging found no evidence of infectious or autoimmune disease. The computed tomography findings led to a diagnosis of diffuse alveolitis. The candesartan treatment was stopped and oral corticosteroid therapy (50 mg/day) initiated. The rapid favorable outcome supports the diagnosis of a drug-induced infiltrative lung disease.
Service de Médecine A, Centre Hospitalier de Libreville, Libreville, Gabon. ibabajose@yahoo.fr
J
J
Iba Ba
D
D
Mounguengui
T
T
Ella Ondo
D000959:Antihypertensive Agents / Q000009:adverse effects; D001562:Benzimidazoles / Q000009:adverse effects; D001713:Biphenyl Compounds; D006801:Humans; D006852:Hydrochlorothiazide / Q000009:adverse effects; D008171:Lung Diseases / Q000139:chemically induced / Q000000981:diagnostic imaging*; D008297:Male; D008875:Middle Aged; D011650:Pulmonary Alveoli / Q000000981:diagnostic imaging; D011859:Radiography; D013777:Tetrazoles / Q000009:adverse effects
D000959:Antihypertensive Agents; D001562:Benzimidazoles; D001713:Biphenyl Compounds; D013777:Tetrazoles; D006852:Hydrochlorothiazide; C081643:candesartan