[Fenibut and its citrate prevent psychoneurological disorders caused by chronic stress (paradoxical sleep deprivation)].
The antistress protective action of two structural analogs of GABA, fenibut and its salt with citric acid (fenibut citrate, citrocard, RGPU-147), has been studied using a model of chronic stress caused by seven-fold 24-h deprivation of paradoxical sleep phase at an interval of 24 h between the deprivations. It is established that fenibut and fenibut citrate produce a protective action by (i) reducing the intensity of emotional disorders in the open-field test and elevated plus maze test, (ii) decreasing cognitive disorders in the tests for conditioned avoidance response and extrapolatory deliverance; and (iii) limiting stress reaction due to a decrease in the intensity of adrenal hypertrophy, thymus involution, and stomach mucous membrane ulceration. Fenibut citrate surpasses fenibut in the intensity of antistress protective action.
I N
IN
Tiurenkov
V V
VV
Bagmetova
L E
LE
Borodkina
V M
VM
Berestovitskaia
O S
OS
Vasil'eva
D000311:Adrenal Glands / Q000187:drug effects / Q000503:physiopathology; D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects; D001522:Behavior, Animal / Q000187:drug effects; D002951:Citrates; D003072:Cognition Disorders / Q000188:drug therapy* / Q000503:physiopathology; D006801:Humans; D008297:Male; D018782:Maze Learning / Q000187:drug effects; D009497:Neurotic Disorders / Q000188:drug therapy* / Q000503:physiopathology; D051381:Rats; D012892:Sleep Deprivation / Q000188:drug therapy* / Q000503:physiopathology; D012895:Sleep, REM; D013270:Stomach / Q000187:drug effects / Q000503:physiopathology; D013312:Stress, Physiological / Q000187:drug effects; D013950:Thymus Gland / Q000187:drug effects / Q000503:physiopathology; D014149:Tranquilizing Agents / Q000627:therapeutic use*; D005680:gamma-Aminobutyric Acid / Q000031:analogs & derivatives* / Q000627:therapeutic use
D002951:Citrates; D014149:Tranquilizing Agents; D005680:gamma-Aminobutyric Acid; C008842:4-amino-3-phenylbutyric acid