Protein-polymer hybrid nanoparticles for drug delivery.
Amphiphilic bovine serum albumin-poly(methyl methacrylate) conjugate forms nanoparticles with the uniform size of ~100 nm by self-assembling. Loaded with the hydrophobic anti-tumor drug camptothecin, the nanoparticle efficiently delivers drugs into cancer cells, and thus inhibits ~79% of tumor growth in animals compared with free drug.
Department of Chemistry, Stanford University, Stanford, CA 94305-5080, USA.
Jun
J
Ge
Evgenios
E
Neofytou
Jiandu
J
Lei
Ramin E
RE
Beygui
Richard N
RN
Zare
D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry* / Q000494:pharmacology; D002166:Camptothecin / Q000494:pharmacology; D045744:Cell Line, Tumor; D016503:Drug Delivery Systems; D057927:Hydrophobic and Hydrophilic Interactions; D053758:Nanoparticles / Q000737:chemistry*; D010316:Particle Size; D019904:Polymethyl Methacrylate / Q000737:chemistry* / Q000494:pharmacology; D012710:Serum Albumin, Bovine / Q000737:chemistry* / Q000494:pharmacology
D000970:Antineoplastic Agents; C584531:bovine serum albumin-poly(methyl methacrylate) conjugate; D012710:Serum Albumin, Bovine; D019904:Polymethyl Methacrylate; D002166:Camptothecin