[Two different receptors for wild type measles virus].
Measles is a highly contagious acute viral disease characterized by a maculopapular rash. It causes severe and temporary immune suppression and is often accompanied by secondary bacterial infections. In 2000, signaling lymphocyte activation molecule (SLAM) was identified as a receptor for measles virus (MV). Observations that SLAM is expressed on cells of the immune system provided a good explanation for the lymphotropic and immunosuppressive nature of MV. However, molecular mechanisms of highly contagious nature of MV have remained unclear. Previously we have demonstrated that MV has an intrinsic ability to infect polarized epithelial cells by using a receptor other than SLAM. Recently, nectin4, a cellular adhesion junction molecule, was identified as the epithelial cell receptor for MV. Understanding the molecular mechanisms of MV to infect both epithelial and immune cells provides a deep insight into measles pathogenesis.
Department of Virology III, National Institute of Infectious Diseases Gakuen 4-7-1, Musashimurayama, Tokyo 208-0011, Japan. maino@nih.go.jp
Maino
M
Tahara
Makoto
M
Takeda
D000818:Animals; D015703:Antigens, CD; D015815:Cell Adhesion Molecules; D004847:Epithelial Cells / Q000821:virology; D006801:Humans; D007107:Immune System / Q000166:cytology / Q000821:virology; D008457:Measles / Q000276:immunology / Q000821:virology*; D008459:Measles virus / Q000235:genetics* / Q000276:immunology / Q000472:pathogenicity*; D051916:Membrane Cofactor Protein; D011956:Receptors, Cell Surface; D000071177:Signaling Lymphocytic Activation Molecule Family Member 1; D000075983:Nectins
D015703:Antigens, CD; D015815:Cell Adhesion Molecules; D051916:Membrane Cofactor Protein; D011956:Receptors, Cell Surface; D000071177:Signaling Lymphocytic Activation Molecule Family Member 1; C497857:CD46 protein, human; C442228:NECTIN4 protein, human; D000075983:Nectins