Surgical intervention in childhood intermittent exotropia: current practice and clinical outcomes from an observational cohort study.
OBJECTIVE
To describe surgical outcomes in intermittent exotropia (X(T)), and to relate these to preoperative and surgical characteristics.


METHODS
87 children (aged <11 years) underwent surgery in 18 UK centres; review data (mean 21 months post-surgery) were available for 72. The primary outcome measure was motor/sensory outcome (angle and stereoacuity). The secondary outcome measure was satisfactory control assessed by Newcastle Control Score (NCS).


RESULTS
35% of patients had excellent, 28% had fair and 37% had poor primary outcome. Preoperative and surgical characteristics did not influence primary outcome. Satisfactory control was achieved in 65% of patients, while X(T) remained/recurred in 20%. Persistent over-correction occurred in 15% of children. There was no relationship between over-correction and preoperative characteristics or surgical dose/type. Median angle improved by 12 prism dioptres (PD) at near and 19 PD at distance (p<0.001). Median NCS improved by 5 (p<0.001). 40% of those initially over-corrected remained so by last postoperative assessment; no relationship was found between an initial over-correction and good outcome.


CONCLUSIONS
Whilst excellent motor/sensory outcome was achieved in one-third and satisfactory control in two-thirds of patients, the 37% poor outcome and 15% persistent over-correction rate is of concern. Surgical dose was similar in those under- and over-corrected, suggesting that over-corrections cannot be avoided merely by getting the dosage right: a randomised controlled trial (RCT) would shed light on this issue. Initial over-correction did not improve the chance of a good outcome, supporting the growing literature on this topic and further highlighting the need for randomised controlled trials of X(T) surgery.
Institute of Neuroscience, Newcastle University, Newcastle upon Tyne, UK. deborah.buck@ncl.ac.uk
Deborah
D
Buck
Christine J
CJ
Powell
John J
JJ
Sloper
Robert
R
Taylor
Peter
P
Tiffin
Michael P
MP
Clarke
D000550:Amblyopia / Q000209:etiology; D002648:Child; D002675:Child, Preschool; D015331:Cohort Studies; D004502:Education, Medical, Continuing; D005099:Exotropia / Q000601:surgery*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007223:Infant; D008297:Male; D013508:Ophthalmologic Surgical Procedures / Q000009:adverse effects / Q000379:methods* / Q000592:standards; D011183:Postoperative Complications / Q000209:etiology; D011300:Preoperative Care / Q000379:methods* / Q000592:standards; D016896:Treatment Outcome; D006113:United Kingdom; D014792:Visual Acuity