Poly-α,β-DL-aspartyl-L-cysteine: a novel nanomaterial having a porous structure, special complexation capability for Pb(II), and selectivity of removing Pb(II).
Poly-α,β-DL-aspartic acid is known as a green chelant of various metal ions. To provide a novel nanochelant for treating Pb(II) poisoning, poly-α,β-DL-aspartic acid was modified with L-Cys to form poly-α,β-DL-aspartyl-L-cysteine (PDC; MW, 27273). DL-Asp was converted into polysuccinimide through a thermal polycondensation, and the amidation of polysuccinimide with L-Cys provided PDC. In water, PDC formed various porous nanospecies. In the mouse lead intoxication model, both intraperitoneal and oral administration of PDC (0.1, 1.0, and 10.0 nmol/kg) dose dependently removed Pb(II) accumulated in the organ, bone, and blood. PDC did not remove the essential metals including Cu(2+), Fe(2+), Mn(2+), Zn(2+), and Ca(2+) of the treated mice. The porous feature and size of the pH- and concentration-dependent nanospecies of PDC benefited the removal of Pb(II).
College of Pharmaceutical Sciences, Capital Medical University, Beijing 100069, People's Republic of China.
Li
L
Li
Jianhui
J
Wu
Ming
M
Zhao
Yuji
Y
Wang
Huiliang
H
Zhang
Xiaoyi
X
Zhang
Lin
L
Gui
Jiawang
J
Liu
Nathan
N
Mair
Shiqi
S
Peng
D000284:Administration, Oral; D000818:Animals; D002851:Chromatography, High Pressure Liquid; D056831:Coordination Complexes / Q000737:chemistry* / Q000378:metabolism; D003545:Cysteine / Q000031:analogs & derivatives*; D005243:Feces / Q000737:chemistry; D006863:Hydrogen-Ion Concentration; D007854:Lead / Q000737:chemistry* / Q000652:urine; D008297:Male; D051379:Mice; D049329:Nanostructures / Q000737:chemistry*; D010455:Peptides / Q000138:chemical synthesis / Q000737:chemistry*; D016062:Porosity; D014018:Tissue Distribution
D056831:Coordination Complexes; D010455:Peptides; C577764:poly-alpha,beta-aspartyl-cysteine; D007854:Lead; D003545:Cysteine