[Structural changes of some organs in rats after a single intravenous injection of magnetite nanoparticles].
The aim of this investigation was to study the morphological changes of liver, lung, kidneys and spleen as well as of the cells of mononuclear pahagocyte system in 60 rats 1-40 days after a single intravenous injection of a suspension of magnetite nanoparticles. Moderate hemodynamic disturbances and focal necrotic changes were detected in the hepatic and renal parenchyma. In the lungs and spleen, only hemodynamic disturbances were found. The degree of morphological changes in rat liver, lungs, kidneys and spleen was decreased by day 10. Using Perls histochemical method, the accumulation of nanoparticles was detected in the cells of mononuclear phagocyte system of the organs studied.
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Mil'to
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Sukhodolo
D000818:Animals; D006439:Hemodynamics / Q000187:drug effects; D007275:Injections, Intravenous; D007668:Kidney / Q000187:drug effects / Q000473:pathology; D008099:Liver / Q000187:drug effects / Q000473:pathology; D008168:Lung / Q000187:drug effects / Q000473:pathology; D058185:Magnetite Nanoparticles / Q000008:administration & dosage*; D012157:Mononuclear Phagocyte System / Q000187:drug effects / Q000473:pathology; D051381:Rats; D013154:Spleen / Q000187:drug effects / Q000473:pathology
D058185:Magnetite Nanoparticles