Gene-gene interactions in IL23/Th17 pathway contribute to psoriasis susceptibility in Chinese Han population.
BACKGROUND
Psoriasis is a common chronic inflammatory skin disease. IL23/Th17 is a newly confirmed pathway in psoriasis.


OBJECTIVE
To investigate the gene-gene interactions in IL23/Th17 pathway underlying psoriasis.


METHODS
A total of 299 single-nucleotide polymorphisms from 11 genes in IL23/Th17 pathway were genotyped on 1139 patients with psoriasis and 1694 controls. Multifactor dimensionality reduction and logistic regression algorithms were applied to explore the gene-gene interactions.


RESULTS
We found that there were a three-way interaction among IL21, CCR4 and TNF(χ(2) = 5.02(1), P = 0.025) and three pair-wise gene-gene interactions between IL12RB1 and CCR4(χ(2) = 11.66(4), P = 0.0201), IL22 and CCR4 (χ(2) = 11.97(4), P = 0.0176), IL12RB1 and IL6 (χ(2) = 7.31(1), P = 0.0069) in psoriasis.


CONCLUSIONS
Our results might be helpful for explaining the missing heritability of the psoriasis due to epistasis and provide a deep insight into the important role of the IL23/Th17 pathway in the pathogenesis of psoriasis.
Institute of Dermatology and Department of Dermatology, No.1 Hospital, Anhui Medical University, 81 Meishan Road, Hefei, Anhui, China.
W-J
WJ
Wang
X-Y
XY
Yin
X-B
XB
Zuo
H
H
Cheng
W-D
WD
Du
F-Y
FY
Zhang
S
S
Yang
X-J
XJ
Zhang
D000328:Adult; D044466:Asian People / Q000235:genetics; D016022:Case-Control Studies; D004843:Epistasis, Genetic; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D008297:Male; D011565:Psoriasis / Q000235:genetics*; D018123:Receptors, Interleukin / Q000235:genetics*; D053722:Receptors, Interleukin-17 / Q000235:genetics*; D015398:Signal Transduction / Q000235:genetics
C109985:IL17RA protein, human; C515500:IL23R protein, human; D018123:Receptors, Interleukin; D053722:Receptors, Interleukin-17