Modification of sodium, glucose, potassium, and osmolarity in packed red blood cells and fresh frozen plasma using a desktop hemoconcentrator setup.
Massive transfusion with packed blood cells (PRBCs) or fresh frozen plasma (FFP) can result in dangerous complications including stroke, kidney failure, and cardiac arrest. A simple, bench top technique using a hemoconcentrator and dialysate solution is described to correct critical values of sodium, glucose, potassium, and osmolarity in PRBCs and FFP. Sodium, glucose, and osmolarity were corrected to normal or near normal values. Elevated potassium was reduced by 65%, but not completely normalized. A simple, bench top method for correcting dangerous abnormalities with PRBCs and FFP can be used to improve the safety of massive blood transfusion.
Department of Cardiothoracic Surgery, Children's Mercy Hospitals and Clinics, 2401 Gillham Road, Kansas City, MO 64108, USA. clstriker@cmh.edu
Carrie Whittaker
CW
Striker
Stacia
S
Woldorf
David
D
Holt
D004869:Equipment Safety; D017707:Erythrocyte Transfusion / Q000295:instrumentation* / Q000379:methods; D004912:Erythrocytes / Q000737:chemistry*; D005947:Glucose / Q000032:analysis; D015312:Hemodialysis Solutions / Q000737:chemistry; D006801:Humans; D009994:Osmolar Concentration; D010949:Plasma / Q000737:chemistry*; D010951:Plasma Exchange / Q000295:instrumentation* / Q000379:methods; D011188:Potassium / Q000097:blood; D012964:Sodium / Q000097:blood
D015312:Hemodialysis Solutions; D012964:Sodium; D005947:Glucose; D011188:Potassium