Chemoenzymatic preparation of germacrene analogues.
A small library of novel germacrenes was generated using a combination of two plant enzymes, germacrene A synthase, and D synthase and modified farnesyl diphosphate (FDP) analogues. This chemoenzymatic approach allows the preparation of potentially valuable volatiles for biological studies.
School of Chemistry and Cardiff Catalysis Institute, Cardiff University, Main Building, Park Place, Cardiff CF10 3AT, UK.
Oscar
O
Cascón
Sabrina
S
Touchet
David J
DJ
Miller
Veronica
V
Gonzalez
Juan A
JA
Faraldos
Rudolf K
RK
Allemann
D019883:Alkyl and Aryl Transferases / Q000737:chemistry / Q000378:metabolism*; D015394:Molecular Structure; D045788:Sesquiterpenes, Germacrane / Q000096:biosynthesis* / Q000737:chemistry; D054852:Small Molecule Libraries / Q000737:chemistry / Q000378:metabolism*; D036624:Solidago / Q000201:enzymology; D013237:Stereoisomerism
D045788:Sesquiterpenes, Germacrane; D054852:Small Molecule Libraries; C471077:germacrene A; D019883:Alkyl and Aryl Transferases; C577204:germacrene A synthase, Solidago canadensis; C470416:germacrene D synthase; C027259:germacrene D