Enantioselective alkylation of β-keto phosphonates by direct use of diaryl methanols as electrophiles.
Enantioselective alkylation of β-keto phosphonates with diaryl methanols in the presence of catalytic amounts of copper(II) trifluoromethanesulfonate and an optically active ligand gives the corresponding alkylated products in good to high yields with a high enantioselectivity.
Institute of Engineering Innovation, School of Engineering, The University of Tokyo, Yayoi, Bunkyo-ku, Tokyo 113-8656, Japan.
Masashi
M
Shibata
Masahiro
M
Ikeda
Kazuki
K
Motoyama
Yoshihiro
Y
Miyake
Yoshiaki
Y
Nishibayashi