Molecular logic gates for DNA analysis: detection of rifampin resistance in M. tuberculosis DNA.
Elementary, Dr. Watson! A combination of YES and OR logic gates was applied to differentiate between DNA sequences of wild-type and rifampin-resistant (Rif(r)) Mycobacterium tuberculosis (Mtb) in a multiplex real-time fluorescent assay.
Chemistry Department, University of Central Florida, Orlando, FL 32816, USA.
Evan M
EM
Cornett
Eleanor A
EA
Campbell
George
G
Gulenay
Evan
E
Peterson
Neha
N
Bhaskar
Dmitry M
DM
Kolpashchikov
D000904:Antibiotics, Antitubercular / Q000494:pharmacology*; D004269:DNA, Bacterial / Q000032:analysis*; D024881:Drug Resistance, Bacterial / Q000187:drug effects; D009169:Mycobacterium tuberculosis / Q000187:drug effects / Q000235:genetics* / Q000302:isolation & purification; D016133:Polymerase Chain Reaction; D012293:Rifampin / Q000494:pharmacology*; D013050:Spectrometry, Fluorescence
D000904:Antibiotics, Antitubercular; D004269:DNA, Bacterial; D012293:Rifampin