Leishmanicidal and anticandidal activity of constituents of Indian edible mushroom Astraeus hygrometricus.
Two new lanostane-type triterpenes, 1 and 2, were isolated from Astraeus hygrometricus. The structures were established by IR, (1)H- and (13)C-NMR, MS, and X-ray crystallographic experiments. The triterpenes exhibited excellent in vitro toxicities against Candida albicans, comparable to standard antifungal antibiotics. The triterpene 2 significantly inhibited the growth of Leishmania donovani promastigotes in vitro. The triterpene skeleton may be considered a template structure in search for new compounds with anticandidal and leishmanicidal activity.
Department of Chemistry, Vidyasagar Evening College, 39, Sankar Ghosh Lane, Kolkata 700006, India.
Tapan K
TK
Lai
Gunjan
G
Biswas
Soumya
S
Chatterjee
Aritri
A
Dutta
Chiranjib
C
Pal
Julie
J
Banerji
Nattamai
N
Bhuvanesh
Joseph H
JH
Reibenspies
Krishnendu
K
Acharya
D000818:Animals; D000935:Antifungal Agents / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D000981:Antiprotozoal Agents / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D001487:Basidiomycota / Q000737:chemistry*; D002176:Candida albicans / Q000187:drug effects; D002177:Candidiasis / Q000188:drug therapy; D018360:Crystallography, X-Ray; D006801:Humans; D007893:Leishmania donovani / Q000187:drug effects; D007898:Leishmaniasis, Visceral / Q000188:drug therapy; D051379:Mice; D008807:Mice, Inbred BALB C; D008958:Models, Molecular; D014315:Triterpenes / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*
D000935:Antifungal Agents; D000981:Antiprotozoal Agents; D014315:Triterpenes