Memory CD4(+) T lymphocytes in the gastrointestinal tract are a major source of cell-associated simian immunodeficiency virus in chronic nonpathogenic infection of African green monkeys.
Simian immunodeficiency virus (SIV) infection of natural hosts is characterized by nonpathogenic chronic viremia, maintenance of gastrointestinal epithelial barrier integrity, and low numbers of target cells. Assessment of cell-associated virus load in T cell subsets in multiple anatomic compartments of chronically SIV-infected sabeus African green monkeys (AGMs) revealed that gastrointestinal memory CD4(+) T lymphocytes are a major source of cell-associated virus and a significant contributor to SIV viremia in AGMs.
Division of Viral Pathogenesis, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA.
Joern E
JE
Schmitz
Zhong-Min
ZM
Ma
Emily A
EA
Hagan
Andrew B
AB
Wilks
Kathryn L
KL
Furr
Caitlyn H
CH
Linde
Roland C
RC
Zahn
Jason M
JM
Brenchley
Christopher J
CJ
Miller
Sallie R
SR
Permar
D000818:Animals; D015704:CD4 Antigens / Q000235:genetics; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology / Q000821:virology*; D002522:Chlorocebus aethiops; D041981:Gastrointestinal Tract / Q000276:immunology* / Q000821:virology*; D007156:Immunologic Memory; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D016097:Simian Acquired Immunodeficiency Syndrome / Q000276:immunology* / Q000821:virology*; D015302:Simian Immunodeficiency Virus / Q000276:immunology / Q000502:physiology*; D019562:Viral Load; D014766:Viremia
D015704:CD4 Antigens; D012333:RNA, Messenger