Susceptibility of non-enveloped DNA- and RNA-type viruses to photodynamic inactivation.
The comparative susceptibility of DNA- and RNA-type viruses to photodynamic inactivation has not yet been clearly addressed. In this study the effect of the tricationic porphyrin Tri-Py(+)-Me-PF on the inactivation of four DNA and three RNA non-enveloped phages was compared. The results obtained show that the photodynamic efficiency varied with the phage type, the RNA-type phages being much more easily photoinactivated than the DNA-type ones.
Department of Biology and CESAM, University of Aveiro, 3810-193 Aveiro, Portugal.
Liliana
L
Costa
João P C
JP
Tomé
Maria G P M S
MG
Neves
Augusto C
AC
Tomé
José A S
JA
Cavaleiro
Angela
A
Cunha
Maria A F
MA
Faustino
Adelaide
A
Almeida
D001419:Bacteria / Q000821:virology; D001435:Bacteriophages / Q000187:drug effects / Q000502:physiology* / Q000528:radiation effects; D004267:DNA Viruses / Q000187:drug effects / Q000502:physiology* / Q000528:radiation effects; D004121:Dimethyl Sulfoxide / Q000737:chemistry; D008027:Light; D009682:Magnetic Resonance Spectroscopy; D010782:Photolysis; D017319:Photosensitizing Agents / Q000138:chemical synthesis / Q000494:pharmacology*; D011166:Porphyrins / Q000138:chemical synthesis / Q000494:pharmacology*; D012328:RNA Viruses / Q000187:drug effects / Q000502:physiology* / Q000528:radiation effects; D013045:Species Specificity; D005464:Fluorobenzenes; D005466:Fluorocarbons
D004121:Dimethyl Sulfoxide; D017319:Photosensitizing Agents; D011166:Porphyrins; C549552:5,10,15-tris(1-methylpyridinium-4-yl)-20-(pentafluorophenyl)porphyrin triiodide; D005464:Fluorobenzenes; D005466:Fluorocarbons