Pharmaceutical potential of phorbol esters from Jatropha curcas oil.
Phorbol esters (PEs) are diterpenes present in Jatropha curcas L. seeds and have a myriad of biological activities. Since PEs are toxic, they are considered to be futile in Jatropha-based biodiesel production chain. In the present study, the extracted PEs from Jatropha oil were used as a starting material to synthesise pharmacologically important compound, prostratin. The prostratin synthesised from Jatropha showed identical mass with that of the reference standard prostratin, as determined by Nano-LC-ESI-MS/MS. Considering the rapid growth in Jatropha biodiesel industry, potential exists to harness large amount of PEs which can be further utilised to synthesise prostratin as a value added product.
a Institute for Animal Production in the Tropics and Subtropics, (480b), University of Hohenheim , Stuttgart - 70599 , Germany.
Rakshit K
RK
Devappa
Chandi C
CC
Malakar
Harinder P S
HP
Makkar
Klaus
K
Becker
D031286:Jatropha / Q000737:chemistry*; D010703:Phorbol Esters / Q000737:chemistry*; D010938:Plant Oils / Q000737:chemistry*; D021241:Spectrometry, Mass, Electrospray Ionization; D053719:Tandem Mass Spectrometry
D010703:Phorbol Esters; D010938:Plant Oils