[Vitamin D tweets light to genes in multiple sclerosis].
The relationship between sunlight exposure and the incidence of multiple sclerosis and the understanding of immunomodulatory effects of vitamin D triggered, in recent years, a broad range of investigations. Immunological studies performed in vitro and in vivo have demonstrated how tolerogenic vitamin D can be. Epidemiological studies confirmed an increased incidence of multiple sclerosis in vitamin D deficient subjects and signs of increased disease activity in such MS patients. Although small-scale observational studies have suggested a beneficial impact of vitamin D supplementation on the incidence and severity of multiple sclerosis, large scale clinical trials remain warranted to confirm these preliminary results.
MYelin Disorders REseArch teaM (MYDREAM), Liège, Belgique. elommers@chu.ulg.ac.be
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Lommers
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Phan-Ba
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Belachew
D000818:Animals; D018450:Disease Progression; D006801:Humans; D056747:Immunomodulation / Q000187:drug effects / Q000235:genetics / Q000502:physiology; D009103:Multiple Sclerosis / Q000175:diagnosis / Q000209:etiology* / Q000235:genetics* / Q000517:prevention & control; D011379:Prognosis; D015398:Signal Transduction / Q000235:genetics; D014807:Vitamin D / Q000378:metabolism / Q000494:pharmacology / Q000502:physiology* / Q000627:therapeutic use; D014808:Vitamin D Deficiency / Q000097:blood / Q000150:complications / Q000175:diagnosis / Q000235:genetics
D014807:Vitamin D