A positive magnetic resonance spectroscopic imaging with negative initial biopsy may predict future detection of prostate cancer.
Current diagnostic modalities for early prostate cancer (PCa) lack sufficient sensitivity and specificity. Magnetic resonance spectroscopic imaging (MRSI) detects biochemical changes in tissues that may predate histological changes that can be diagnosed on a biopsy. Men with MRSI suggestive of malignancy but negative biopsy may thus be harboring cancer that manifests at a later date. We report the first case in our cohort of men with positive MRSI but negative initial biopsy who, 6 years after the initial MRSI, were detected to have PCa despite a "normal" prostate specific antigen (<4.0 ng/ml).
Department of NMR, All India Institute of Medical Sciences, New Delhi, India.
Durgesh Kumar
DK
Dwivedi
Virendra
V
Kumar
Tarun
T
Javali
Amit K
AK
Dinda
Sanjay
S
Thulkar
Naranmangalam R
NR
Jagannathan
Rajeev
R
Kumar