The fetal fraction of cell-free DNA in maternal plasma is not affected by a priori risk of fetal trisomy.
OBJECTIVE
To determine the relationship between a priori risk for fetal trisomy and the fraction of fetal cell-free DNA (cfDNA) in maternal blood.


METHODS
A comparative analysis on fetal cfDNA amounts was performed in subjects stratified into a priori risk groups based on maternal age, prenatal screening results, or nuchal translucency measurement.


RESULTS
Across the highest and lowest deciles within each group, there were no significant differences in the fetal cfDNA fraction.


CONCLUSIONS
These data support the concept that non-invasive prenatal test performance as determined by fetal cfDNA fraction is not predicted to be different based on patient risk classification.
Riverside Perinatal Diagnostic Center, Riverside, CA, USA.
Herb
H
Brar
Eric
E
Wang
Craig
C
Struble
Thomas J
TJ
Musci
Mary E
ME
Norton
D000293:Adolescent; D000328:Adult; D004247:DNA / Q000097:blood*; D005260:Female; D006801:Humans; D008423:Maternal Age; D008875:Middle Aged; D048208:Nuchal Translucency Measurement; D011247:Pregnancy; D012307:Risk Factors; D014314:Trisomy / Q000175:diagnosis*; D055815:Young Adult
D004247:DNA