Dapsone induced eosinophilic pneumonia.
Eosinophilic lung diseases (ELD) are a variety of several clinical entities, which may result from different etiologies, including drug treatment. Dapsone, a sulfone antibiotic widely used in leprosy (among other indications), has been described as a possible cause of ELD. We report a patient with leprosy who presented with respiratory symptoms and pulmonary infiltrates and was diagnosed as suffering from eosinophilic pneumonia. To the best of our knowledge, this is the first report in which the diagnosis of dapsone-induced eosinophilic pneumonia was supported by bronchoalveolar lavage, lung biopsy and typical response to therapy.
Internal Medicine A Department of Medicine, Hadassah-Hebrew University Medical Center Jerusalem, Israel. adartom@szmc.org.il
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Adar
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Tayer-Shifman
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Mizrahi
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Tavdi
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Barak
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Shalit
D000368:Aged; D001706:Biopsy; D002991:Clofazimine / Q000627:therapeutic use; D003622:Dapsone / Q000009:adverse effects*; D006801:Humans; D007917:Leprostatic Agents / Q000009:adverse effects*; D015440:Leprosy, Lepromatous / Q000188:drug therapy; D008297:Male; D011657:Pulmonary Eosinophilia / Q000139:chemically induced* / Q000473:pathology* / Q000503:physiopathology; D012293:Rifampin / Q000627:therapeutic use
D007917:Leprostatic Agents; D003622:Dapsone; D002991:Clofazimine; D012293:Rifampin