Copper(I)-catalyzed cascade dearomatization of 2-substituted tryptophols with iodonium [corrected] salts.
Copper(I)-catalyzed dearomative arylation and vinylation of 2-substituted tryptophols were realized with a subsequent cyclization reaction. The cascade dearomatization sequence provided versatile furoindoline derivatives with two quaternary carbon centers in good to excellent yields.
State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Lu, Shanghai 200032, China.
Chuan
C
Liu
Wei
W
Zhang
Li-Xin
LX
Dai
Shu-Li
SL
You
D002244:Carbon; D002384:Catalysis; D003300:Copper / Q000737:chemistry*; D003500:Cyclization; D006575:Heterocyclic Compounds, 3-Ring / Q000138:chemical synthesis* / Q000737:chemistry; D007211:Indoles / Q000737:chemistry*; D015394:Molecular Structure; D012492:Salts; D013237:Stereoisomerism; D000438:Alcohols
D002244:Carbon; D003300:Copper; D006575:Heterocyclic Compounds, 3-Ring; D007211:Indoles; D012492:Salts; C005949:tryptophol; D000438:Alcohols