The antimalarial pipeline--an update.
There are quite a number of antimalarial compounds in different states of preclinical and clinical development. Among those in advanced stages, combinations of known drugs or new substances from drug classes already used in antimalarial therapy are predominant. More compounds with novel or even unknown mechanism of action are found among those compounds which are in less advanced stages of development.
Institut für Pharmazeutische Chemie, Philipps-Universität Marburg, Marbacher Weg 6, D-35032 Marburg, Germany.
Florian C
FC
Schrader
Marlene
M
Barho
Iljana
I
Steiner
Regina
R
Ortmann
Martin
M
Schlitzer
D000634:Aminoquinolines / Q000737:chemistry / Q000494:pharmacology; D000818:Animals; D000962:Antimalarials / Q000737:chemistry / Q000494:pharmacology*; D002986:Clinical Trials as Topic; D004338:Drug Combinations; D004353:Drug Evaluation, Preclinical; D004351:Drug Resistance; D006801:Humans; D020128:Inhibitory Concentration 50; D016778:Malaria, Falciparum / Q000188:drug therapy* / Q000469:parasitology / Q000517:prevention & control*; D010963:Plasmodium falciparum / Q000472:pathogenicity
D000634:Aminoquinolines; D000962:Antimalarials; D004338:Drug Combinations; C001920:4-aminoquinoline