[Effect of radiation-induced bystander chemosignals of mice on the humoral immune response in spleen and lymph nodes of intact recipients].
The ability of post-radiation (4 Gy) bystander chemosignals (the volatile components of mouse urine) to distantly modulate the humoral immune response to the sheep red blood cells in the spleen and popliteal lymph nodes of intact recipients has been investigated. It was shown that the exposure of animals to chemosignals before antigen injection resulted in the decrease and increase of the immune response in the spleen and lymph nodes, respectively. When animals were exposed to chemosignals after the antigenic stimulus, an increased immune response was observed in both spleen and lymph nodes. The contribution of radiation-induced bystander signaling in the response of socially organized animals to the effect of ionizing irradiation is discussed.
A N
AN
Sharetskiĭ
V A
VA
Kharlamov
B P
BP
Surinov
D000818:Animals; D000921:Antibody-Producing Cells / Q000166:cytology / Q000187:drug effects / Q000276:immunology / Q000528:radiation effects; D000941:Antigens / Q000276:immunology; D024201:Bystander Effect / Q000528:radiation effects*; D002452:Cell Count; D004912:Erythrocytes / Q000276:immunology; D005720:Gamma Rays; D056724:Immunity, Humoral / Q000187:drug effects / Q000528:radiation effects; D008198:Lymph Nodes / Q000187:drug effects / Q000276:immunology* / Q000528:radiation effects; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D011833:Radiation Injuries, Experimental / Q000276:immunology / Q000652:urine; D012756:Sheep; D013154:Spleen / Q000187:drug effects / Q000276:immunology* / Q000528:radiation effects; D014556:Urine / Q000737:chemistry; D014835:Volatilization; D014916:Whole-Body Irradiation
D000941:Antigens