(Bio)molecular surface patterning by phototriggered oxime ligation.
Making light work of ligation: A novel method utilizes light for oxime ligation chemistry. A quantitative, low-energy photodeprotection generates aldehyde, which subsequently reacts with aminooxy moieties. The spatial control allows patterning on surfaces with a fluoro marker and GRGSGR peptide, and can be imaged by time-of-flight secondary-ion mass spectrometry.
Preparative Macromolecular Chemistry, Institut für Technische Chemie und Polymerchemie and Centre for Functional Nanostructures (CFN), Karlsruhe Institute of Technology (KIT), Karlsruhe, Germany.
Thomas
T
Pauloehrl
Guillaume
G
Delaittre
Michael
M
Bruns
Maria
M
Meißler
Hans G
HG
Börner
Martin
M
Bastmeyer
Christopher
C
Barner-Kowollik
D000595:Amino Acid Sequence; D057930:Click Chemistry; D010091:Oximes / Q000737:chemistry*; D010455:Peptides / Q000737:chemistry; D018629:Spectrometry, Mass, Secondary Ion; D013499:Surface Properties; D014466:Ultraviolet Rays
D010091:Oximes; D010455:Peptides