A glucose-responsive controlled release system using glucose oxidase-gated mesoporous silica nanocontainers.
A glucose-responsive controlled-release system based on the competitive combination between glucose oxidase, glucosamine and glucose has been described, which exhibits perfect controlled release properties and high selectivity for glucose over other monosaccharides. This paved the way for a new generation of stimuli-responsive delivery systems.
Shanghai Key Laboratory of Chemical Biology, School of Pharmacy, East China University of Science and Technology, Meilong Road 130, Shanghai 200237, China.
Mengjie
M
Chen
Chusen
C
Huang
Chunsheng
C
He
Weiping
W
Zhu
Yufang
Y
Xu
Yunfeng
Y
Lu
D005944:Glucosamine / Q000378:metabolism; D005947:Glucose / Q000378:metabolism*; D005949:Glucose Oxidase / Q000378:metabolism*; D053758:Nanoparticles / Q000737:chemistry*; D016062:Porosity; D011485:Protein Binding; D012822:Silicon Dioxide / Q000737:chemistry*
C509968:MCM-41; D012822:Silicon Dioxide; D005949:Glucose Oxidase; D005947:Glucose; D005944:Glucosamine