[Ultrastructural peculiarities of mononuclear macrophages of the demarcation zone in an acute necrotic pancreatitis and elaborating of methods for the disease course prognosis and treatment].
Results of the electron microscopic investigation of the pancreatic tissues biopsies, obtained intraoperatively from the demarcation inflammation focus, while operating 42 patients for an acute necrotic pancreatitis (ANP), were summarized. No less than two populations of mononuclear macrophages, the cells, owing raised or lowered functional activity, were revealed in inflammatory focus of demarcation area. Determination of absolute quantity of monocytes in a peripheral blood was used as a prognostic criterion for the disease course. If the absolute quantity of monocytes did not exceed 400 in 1 mcl of the blood, estradiol dipropionate was used in the ANP treatment, permitting to lower a purulent-septic complications rate, to improve immediate and remote results of treatment.
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Khomiak
D000328:Adult; D000368:Aged; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D004958:Estradiol / Q000031:analogs & derivatives* / Q000627:therapeutic use; D005260:Female; D006801:Humans; D008264:Macrophages / Q000648:ultrastructure*; D008297:Male; D008875:Middle Aged; D010179:Pancreas / Q000648:ultrastructure*; D019283:Pancreatitis, Acute Necrotizing / Q000175:diagnosis / Q000188:drug therapy* / Q000473:pathology*; D011379:Prognosis; D016896:Treatment Outcome; D055815:Young Adult
D000893:Anti-Inflammatory Agents; D004958:Estradiol; C023482:estradiol dipropionate