[Studies of local anaesthetics - part 197. Effect of xylitol on pharmaceutical availability of lidocaine and flow properties of hydrogels].
The paper examines the formulation of hydrogel on the base of a synthetic polymer containing a local anaesthetic and a mass-produced drug in the form of a solution with an antiphlogistic effect. It aimed to prepare a hydrogel of a suitable composition with suitable flow properties and drug release, the active ingredient being lidocaine hydrochloride. Besides the role of a synthetic polymer which ensures that the active ingredient remains at the affected site, an important role in the formulation is played by the presence of an artificial sweetener, which to a great extent as a taste correcting agent of the unpleasant taste of the active ingredient influences the compliance of many patients. The study examined the effect of concentration of the artificial sweetener xylitol on the liberation of the active ingredient from prepared hydrogels. The optimum concentration of the artificial sweetener was adjusted to a degree which does not affect the qualitative properties of the active ingredient.


BACKGROUND
lidocaine hydrochloride, xylitol, hydrogel, liberation.
Univerzita Komenskeho V Bratislave, Bratislava, Slovenska Republika.
Vitková
V
Zuzana
Herdová
H
Petra
Cižmárik
C
Jozef
Grančai
G
Daniel
Benč
B
Lukáš
D000779:Anesthetics, Local / Q000493:pharmacokinetics*; D020136:Hydrogel, Polyethylene Glycol Dimethacrylate; D008012:Lidocaine / Q000493:pharmacokinetics*; D012212:Rheology; D013549:Sweetening Agents / Q000494:pharmacology*; D014993:Xylitol / Q000494:pharmacology*
D000779:Anesthetics, Local; D013549:Sweetening Agents; D020136:Hydrogel, Polyethylene Glycol Dimethacrylate; D008012:Lidocaine; D014993:Xylitol