[Qantitative description of mammalian cell recovery after combined exposure to ionizing radiation with chemical agents].
The parameters of recovery of mammalian cells after exposure to ionizing radiation combined with chemical agents were calculated based on a mathematical model of post-radiation recovery. The data presented, in contrast to the previously published results, indicate that the inhibition of the recovery may be due either to the damage or disruption of the process of recovery or the increase in the part of irreversible damages from which the cells are incapable to recover; or both of these processes can be realized simultaneously. It is concluded that the combination of ionizing radiation with chemical agents that inhibit the recovery processes through the formation of irreversible damages or affect the probability of recovery can be a perspective way in terms of finding the most effective means to increase radiosensitivity.
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Evstratova
D000818:Animals; D002470:Cell Survival / Q000187:drug effects / Q000528:radiation effects; D004307:Dose-Response Relationship, Radiation; D007700:Kinetics; D008322:Mammals; D019216:Metals, Heavy / Q000494:pharmacology*; D008954:Models, Biological; D011829:Radiation Dosage; D011836:Radiation Tolerance / Q000187:drug effects / Q000528:radiation effects; D011839:Radiation, Ionizing; D011838:Radiation-Sensitizing Agents / Q000494:pharmacology*; D013997:Time Factors
D019216:Metals, Heavy; D011838:Radiation-Sensitizing Agents