A predicted miR-27a-mediated network identifies a signature of glioma.
The dysregulation of physiological microRNA (miRNA) activity has been shown             to play an important role in gliomagenesis. In a previous study, using microRNA             arrays and glioma tissues found that miR-27a was upregulated, which was also identified             in the glioma cell lines and samples by quantitative real-time polymerase chain             reaction (qRT-PCR). In this study, in order to explore the potential roles of             miR-27a in the progression of glioma, we first utilized text-mining of PubMed             abstracts with natural language processing (NLP) to identify 1,168 glioma-related             molecules. In addition, miR-27a targets predicted by computational methods were             integrated with the results from NLP analysis, followed by Gene Ontology (GO),             pathway and network analysis. We identified 33 hub genes by overlap calculation             and demonstrated that miR-27a may be involved in the progression of glioma through             adherens junction, focal adhesion, the neurotrophin signaling pathway, the MAPK             signaling pathway, the transforming growth factor-β (TGF-β) signaling pathway,             cytokine-cytokine receptor interactions, the p53 signaling pathway, the apoptotic             signaling pathway, as well as others. Our data may provide researchers with a             better understanding of the mechanisms of the miR-27a-target network in glioma             initiation and progression.
Department of Neurosurgery, Sir Run Run Shaw Hospital, Medical College, Zhejiang University, Hangzhou 310016, PR China.
Shuxu
S
Yang
Kun
K
Wang
Cong
C
Qian
Zhengfei
Z
Song
Peiyu
P
Pu
Anling
A
Zhang
Wei
W
Wang
Huanjiang
H
Niu
Xinwei
X
Li
Xuchen
X
Qi
Yinxin
Y
Zhu
Yirong
Y
Wang
D016543:Central Nervous System Neoplasms / Q000235:genetics* / Q000378:metabolism / Q000473:pathology; D057225:Data Mining; D015972:Gene Expression Regulation, Neoplastic; D053263:Gene Regulatory Networks; D005910:Glioma / Q000235:genetics* / Q000378:metabolism / Q000473:pathology; D006801:Humans; D035683:MicroRNAs
C531388:MIRN27 microRNA, human; D035683:MicroRNAs