Proteomic identification of a direct role for cyclin d1 in DNA damage repair.
The human CCND1 gene, which encodes the cell-cycle protein cyclin D1, is one of the most frequently amplified genes in human cancers. Cyclin D1 activates the cyclin-dependent kinases CDK4 and CDK6 and drives cell proliferation. Beyond the cell-cycle role, the full repertoire of cyclin D1 functions in cancer cells is still unclear. Emerging evidence indicates that cyclin D1 may play a role in DNA damage response. In this review, we discuss observations linking cyclin D1 to DNA damage repair and summarize our recent findings, which show a cyclin D1 function in homologous recombination-mediated DNA repair.
Department of Cancer Biology, Dana-Farber Cancer Institute, and Department of Genetics, Harvard Medical School, Boston, MA 02215, USA.
Siwanon
S
Jirawatnotai
Yiduo
Y
Hu
David M
DM
Livingston
Piotr
P
Sicinski
D019938:Cyclin D1 / Q000378:metabolism*; D004249:DNA Damage; D004260:DNA Repair; D059765:Homologous Recombination; D006801:Humans; D058990:Molecular Targeted Therapy; D009369:Neoplasms / Q000378:metabolism / Q000628:therapy; D059748:Proteolysis; D020543:Proteome; D040901:Proteomics
D020543:Proteome; D019938:Cyclin D1