Intra-amniotic inflammatory response in subgroups of women with preterm prelabor rupture of the membranes.
BACKGROUND
To evaluate the influence of microbial invasion of the amniotic cavity (MIAC) and histological chorioamnionitis (HCA) on the magnitude of intra-amniotic inflammatory response in preterm prelabor rupture of membranes (PPROM).


RESULTS
A prospective cohort study was performed in 107 women with PPROM between 23.0 and 36.6 weeks of gestational age. Twenty-six proteins were assayed by multiple immunoassay in amniotic fluid. The policy for PPROM in Czech Republic is active, and 90% of the women were delivered within 96 hours of membrane rupture. Histopathological placental findings were evaluated based on the Salafia classification. Data were analyzed in four subgroups of population according to the presence of MIAC and/or HCA. Results were stratified by gestational age at PPROM (< or ≥ 34.0 weeks). The rates of MIAC and HCA were 44% and 57%, respectively. Regardless of gestational age at PPROM, intra-amniotic inflammatory response was higher when MIAC and HCA were both present. There were no differences in the intra-amniotic inflammatory response between women with MIAC or HCA alone and women without infection.


CONCLUSIONS
A higher intra-amniotic inflammatory response was identified when both HCA and MIAC were detected.
Maternal-Fetal Medicine Department, ICGON, Hospital Clinic, Universitat de Barcelona, Barcelona, Spain. tcobo@clinic.ub.es
Teresa
T
Cobo
Marian
M
Kacerovsky
Montse
M
Palacio
Helena
H
Hornychova
David M
DM
Hougaard
Kristin
K
Skogstrand
Bo
B
Jacobsson
D000293:Adolescent; D000328:Adult; D000653:Amniotic Fluid / Q000276:immunology* / Q000382:microbiology*; D016207:Cytokines / Q000378:metabolism; D005260:Female; D005322:Premature Rupture of Fetal Membranes / Q000276:immunology* / Q000382:microbiology*; D005865:Gestational Age; D006801:Humans; D011247:Pregnancy; D011446:Prospective Studies; D055815:Young Adult
D016207:Cytokines