Genetically modified species in research: Opportunities and challenges for the histology core laboratory.
Translational research using animal models has traditionally involved genetically modified rodents; however there is increasing use of other novel genetically engineered species. As histology laboratories interface with researchers studying these novel species there will be many situations in which protocols will need to be adapted to the species, model and research goals. This paper gives examples of protocol adaptations to meet research needs and addresses common considerations that should be addressed for all research tissues submitted to the histotechnology laboratory. Positioning the histotechnologist, as well as the investigator, to meet the challenges associated with novel research models will help maximize research efficacy and quality.
Department of Pathology, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, USA.
Alicia K
AK
Olivier
Paul
P
Naumann
Adam
A
Goeken
Christine
C
Hochstedler
Mary
M
Sturm
Janis R
JR
Rodgers
Katherine N
KN
Gibson-Corley
David K
DK
Meyerholz