[Cell fate switch: lineage reprogramming].
It has been demonstrated that mature cells could switch their fate by the technologies for reprogramming, such as somatic cell nuclear transfer and induced pluripotent stem cells. Recently, this conclusion was further confirmed. It was found that mature differentiated cells could be directly converted into other somatic cells or progenitors with some defined transcription factors. This technology is called lineage reprogramming, which provides an attractive novel alternative to regenerative medicine and animal biotechnology. It is a more convenient and more effective system with less ethical issues. Moreover, lineage reprogramming technology could also facilitate researches on regulation of gene expression. This review highlights the procedures of reprogramming, its characteristics, and significant promise in biomedical applications.
College of Animal Science and Technology, Nanjing Agricultural University, Nanjing, China. sunshy2772@163.com
Hong-Yan
HY
Sun
Feng
F
Wang
Wen-Guang
WG
Cao
D000818:Animals; D001709:Biotechnology / Q000379:methods*; D019070:Cell Lineage / Q000235:genetics*; D065150:Cellular Reprogramming / Q000235:genetics*; D006801:Humans; D044968:Regenerative Medicine / Q000379:methods*