Primary cutaneous large B-cell non-Hodgkin lymphoma in first-degree relatives.
Primary cutaneous non-Hodgkin's lymphoma is a heterogeneous group of lymphoproliferative disorders characterized by indolent course, virtually exclusive skin involvement and the absence of systemic disease. We present two brothers, whose mother died of gastric diffuse large B-cell lymphoma, in whom in a period of 4 years primary cutaneous large B-cell non-Hodgkin lymphoma of the skin of the head was diagnosed. They were treated with immunochemotherapy according to R-CHOP protocol (rituximab and adriblastine, cyclophosphamide, oncovine and prednisone) achieving a complete remission. The possible etiological mechanism of this familial lymphoma occurrence is discussed.
Medical Faculty, University Belgrade, Belgrade, Serbia. marcolov@sbb.rs
M
M
Čolović
A
A
Vidovic
N
N
Čolović
M
M
Peruničić-Jovanović
D
D
Tomin
D000328:Adult; D058846:Antibodies, Monoclonal, Murine-Derived / Q000627:therapeutic use; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D003520:Cyclophosphamide / Q000627:therapeutic use; D004317:Doxorubicin / Q000627:therapeutic use; D005192:Family Health; D006258:Head and Neck Neoplasms / Q000188:drug therapy*; D006801:Humans; D054446:Lymphoma, Primary Cutaneous Anaplastic Large Cell / Q000188:drug therapy*; D008297:Male; D011241:Prednisone / Q000627:therapeutic use; D012074:Remission Induction; D000069283:Rituximab; D012535:Scalp; D055771:Serbia; D035781:Siblings; D012878:Skin Neoplasms / Q000188:drug therapy*; D014750:Vincristine / Q000627:therapeutic use
D058846:Antibodies, Monoclonal, Murine-Derived; C571759:R-CHOP protocol; D000069283:Rituximab; D014750:Vincristine; D004317:Doxorubicin; D003520:Cyclophosphamide; D011241:Prednisone