Serum leptin level has a positive correlation with BMI and creatinine clearance in CAPD patients.
OBJECTIVE
In a cross sectional study, 75 patients (42 males and 33 females) on continuous ambulatory peritoneal dialysis (CAPD) were enrolled from October 2007 to February 2008. Serum levels of leptin, albumin, triglyceride, dialysis adequacy (total KT/V), renal creatinine clearance (Cr Cl), mid arm circumference and demographic findings were measured in all patients.


RESULTS
The mean age of patients was 53±14.76. The history of hemodialysis was seen in 23 patients. Mean serum leptin level in women and men were 27±23µg/l and 16±13µg/l, respectively. A significant correlation of serum leptin level with body mass index (BMI) (p<0.001) and renal Cr Cl (p<0.001) was found. There was no significant correlation of serum leptin level with KT/V, duration of renal failure, serum triglycerides (TG), serum low density lipoprotein (LDL) cholesterol and mid arm circumference (p>0.05).


CONCLUSIONS
To our knowledge, this is probably the first study to report that serum leptin level has a direct positive correlation with renal Cr Cl in CAPD patients. This may explain the increase in mortality in patients with lower serum leptin levels (Tab. 2, Fig. 2, Ref. 25).
Department of Nephrology, Isfahan University of Medical Science, Isfahan, Iran.
S
S
Seirafian
A
A
Momeni
S
S
Taheri
M
M
Mortazavi
Z
Z
Paknahad
D015992:Body Mass Index; D003404:Creatinine / Q000378:metabolism*; D005260:Female; D006801:Humans; D007668:Kidney / Q000378:metabolism*; D020738:Leptin / Q000097:blood*; D008055:Lipids / Q000097:blood; D008297:Male; D008875:Middle Aged; D010531:Peritoneal Dialysis, Continuous Ambulatory
D020738:Leptin; D008055:Lipids; D003404:Creatinine