Tumor glucose metabolism imaged in vivo in small animals with whole-body photoacoustic computed tomography.
With the increasing use of small animals for human disease studies, small-animal whole-body molecular imaging plays an important role in biomedical research. Currently, none of the existing imaging modalities can provide both anatomical and glucose molecular information, leading to higher costs of building dual-modality systems. Even with image co-registration, the spatial resolution of the molecular imaging modality is not improved. Utilizing a ring-shaped confocal photoacoustic computed tomography system, we demonstrate, for the first time, that both anatomy and glucose uptake can be imaged in a single modality. Anatomy was imaged with the endogenous hemoglobin contrast, and glucose metabolism was imaged with a near-infrared dye-labeled 2-deoxyglucose.
Washington University in St. Louis, Department of Biomedical Engineering, St. Louis, Missouri 63130, USA.
Muhammad Rameez
MR
Chatni
Jun
J
Xia
Rebecca
R
Sohn
Konstantin
K
Maslov
Zijian
Z
Guo
Yu
Y
Zhang
Kun
K
Wang
Younan
Y
Xia
Mark
M
Anastasio
Jeffrey
J
Arbeit
Lihong V
LV
Wang
D000818:Animals; D045744:Cell Line, Tumor; D005947:Glucose / Q000378:metabolism*; D051379:Mice; D008819:Mice, Nude; D057054:Molecular Imaging; D009374:Neoplasms, Experimental / Q000378:metabolism* / Q000473:pathology*; D061088:Photoacoustic Techniques / Q000379:methods*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D014057:Tomography, X-Ray Computed / Q000379:methods*; D051598:Whole Body Imaging / Q000379:methods*
D005947:Glucose