Influence of impurities on the specific optical rotation of cefozopran.
The impurities of cefozopran hydrochloride are analyzed using high-performance liquid chromatography (HPLC) with UV absorbance and optical rotation (OR) detection. The results show that the impurities can affect the specific optical rotation of the cefozopran product. Due to the different composition of impurities, the Chinese cefozopran hydrochloride product has a specific optical rotation different from the Japanese product. The relationship between impurity limits and specific optical rotation of cefozopran hydrochloride is revealed. The results provide a scientific rationale for setting the limit of specific optical rotation of cefozopran hydrochloride.
Shanghai University of Engineering Science, Shanghai, People's Republic of China.
Shu-Yu
SY
Liu
Ya-Ping
YP
Li
Chang-Qin
CQ
Hu
D000465:Algorithms; D000900:Anti-Bacterial Agents / Q000032:analysis / Q000737:chemistry*; D002511:Cephalosporins / Q000032:analysis / Q000737:chemistry*; D002851:Chromatography, High Pressure Liquid; D004340:Drug Contamination; D009904:Optical Rotation; D012015:Reference Standards; D013056:Spectrophotometry, Ultraviolet; D000097586:Cefozopran
D000900:Anti-Bacterial Agents; D002511:Cephalosporins; D000097586:Cefozopran