The promise of patient-derived xenografts: the best laid plans of mice and men.
Compared with xenografts from previously established cell lines, patient-derived xenografts may more faithfully recapitulate the molecular diversity, cellular heterogeneity, and histology seen in patient tumors, although other limitations of murine models remain. The ability of these models to inform clinical development and answer mechanistic questions will determine their ultimate use.
Department of Gastrointestinal Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA. skopetz@mdanderson.org
Scott
S
Kopetz
Robert
R
Lemos
Garth
G
Powis
D000818:Animals; D002471:Cell Transformation, Neoplastic / Q000187:drug effects*; D015179:Colorectal Neoplasms / Q000188:drug therapy*; D019008:Drug Resistance, Neoplasm / Q000235:genetics*; D005260:Female; D006801:Humans; D008297:Male; D023041:Xenograft Model Antitumor Assays