α-Aminoxylation of ketones and β-chloro-α-aminoxylation of enones with TEMPO and chlorocatecholborane.
Oxidation of various cyclic and acyclic ketones under mild conditions with chlorocatecholborane, a bulky pyridine base, and TEMPO to the corresponding α-aminoxylated products in good to excellent yields (52-99%) is described. For enones as substrates, products of a β-chloro-α-aminoxylation are obtained (70-89%).
Institute of Organic Chemistry, University of Münster, Corrensstrasse 40, 48149 Münster, Germany.
Yi
Y
Li
Martin
M
Pouliot
Thomas
T
Vogler
Philippe
P
Renaud
Armido
A
Studer