Surface characterization and biocompatibility of titanium alloys implanted with nitrogen by Hardion+ technology.
In this study, the new Hardion+ micro-implanter technology was used to modify surface properties of biomedical pure titanium (CP-Ti) and Ti-6Al-4V ELI alloy by implantation of nitrogen ions. This process is based on the use of an electron cyclotron resonance ion source to produce a multienergetic ion beam from multicharged ions. After implantation, surface analysis methods revealed the formation of titanium nitride (TiN) on the substrate surfaces. An increase in superficial hardness and a significant reduction of friction coefficient were observed for both materials when compared to non-implanted samples. Better corrosion resistance and a significant decrease in ion release rates were observed for N-implanted biomaterials due to the formation of the protective TiN layer on their surfaces. In vitro tests performed on human fetal osteoblasts indicated that the cytocompatibility of N-implanted CP-Ti and Ti-6Al-4V alloy was enhanced in comparison to that of the corresponding non treated samples. Consequently, Hardion+ implantation technique can provide titanium alloys with better qualities in terms of corrosion resistance, cell proliferation, adhesion and viability.
INSA Rennes, UMR CNRS 6226 Sciences Chimiques de Rennes/Chimie Métallurgie, 20 Avenue des Buttes de Coësmes, 35043, Rennes Cedex, France.
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D000497:Alloys / Q000737:chemistry*; D001672:Biocompatible Materials / Q000737:chemistry; D002448:Cell Adhesion; D049109:Cell Proliferation; D002470:Cell Survival; D003343:Corrosion; D005109:Extracellular Matrix / Q000378:metabolism; D005353:Fibronectins / Q000737:chemistry; D006801:Humans; D007477:Ions; D013058:Mass Spectrometry / Q000379:methods; D008422:Materials Testing; D009584:Nitrogen / Q000737:chemistry* / Q000378:metabolism; D010006:Osteoblasts / Q000166:cytology; D019736:Prostheses and Implants; D013499:Surface Properties; D013696:Temperature; D014025:Titanium / Q000737:chemistry*
D000497:Alloys; D001672:Biocompatible Materials; D005353:Fibronectins; D007477:Ions; C041500:titanium nitride; D014025:Titanium; D009584:Nitrogen