Kynurenic acid in plasma and endometrium in bitches with pyometra.
Kynurenic acid (KYNA) is produced enzymatically in humans and animals from kynurenine. Reports concerning changes of kynurenine metabolism during inflammation are available in the literature. Pyometra is a pathological condition characterized by the accumulation of pus in the uterine lumen and bacterial infection. The objective of the study was to compare the serum and endometrial KYNA concentrations in healthy bitches and those with pyometra. KYNA was determined by means of high-performance liquid chromatography with fluorometric detection. The serum content of KYNA in bitches with pyometra was significantly higher than in healthy bitches. The KYNA content in the endometrium of bitches with pyometra was higher, yet the difference was not statistically significant. Our result indicates that determination of KYNA might be a marker of pyometra in bitches.
Department and Clinic of Animal Reproduction, Faculty of Veterinary Medicine, University of Life Sciences in Lublin, Głęboka 30, 20-612, Lublin, Poland.
Roman
R
Dąbrowski
Tomasz
T
Kocki
Marek
M
Szczubiał
Wojciech
W
Dąbrowski
Jolanta
J
Parada-Turska
D000818:Animals; D015415:Biomarkers / Q000097:blood; D004283:Dog Diseases / Q000097:blood / Q000378:metabolism* / Q000382:microbiology / Q000473:pathology; D004285:Dogs; D004714:Endometrial Hyperplasia / Q000382:microbiology / Q000473:pathology / Q000662:veterinary; D004717:Endometrium / Q000378:metabolism*; D004926:Escherichia coli; D005260:Female; D007736:Kynurenic Acid / Q000097:blood*; D007737:Kynurenine / Q000378:metabolism; D055112:Pyometra / Q000097:blood / Q000378:metabolism / Q000662:veterinary*; D013210:Staphylococcus; D014591:Uterine Diseases / Q000097:blood / Q000382:microbiology / Q000473:pathology / Q000662:veterinary; D014599:Uterus / Q000382:microbiology / Q000473:pathology
D015415:Biomarkers; D007737:Kynurenine; D007736:Kynurenic Acid