Using haplotype analysis to elucidate significant associations between genes and Hodgkin lymphoma.
In this study, we estimated the association between the inferred haplotypes in the inflammation, DNA repair, and folate pathways, and developed risk models for Hodgkin lymphoma. The study population consisted of 200 Hodgkin lymphoma cases and 220 controls. A susceptible association was observed on the XPC gene with haplotype CT (rs2228001 and rs2228000), and a protective association was observed on the IL4R gene with haplotype TCA (rs1805012, rs1805015, and rs1801275). These results can provide the necessary tools to identify high-risk individuals after validation in large data sets.
The University of Texas Graduate School for Biomedical Sciences, Houston, TX 77030, United States.
Anthony M
AM
D'Amelio
Claudia
C
Monroy
Randa
R
El-Zein
Carol J
CJ
Etzel
D004268:DNA-Binding Proteins / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D006239:Haplotypes; D006689:Hodgkin Disease / Q000235:genetics*; D006801:Humans; D053662:Interleukin-4 Receptor alpha Subunit / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide
D004268:DNA-Binding Proteins; C504000:IL4R protein, human; D053662:Interleukin-4 Receptor alpha Subunit; C086984:XPC protein, human