Prevention of biofilm formation on urinary catheters: comparison of the sparfloxacin-treated long-term antimicrobial catheters with silver-coated ones.
Urinary catheters are widely used for hospitalized patients and are often associated with high risk of urinary tract infection. The agar and broth diffusion tests, visual TTC (triphenyltetrazolium chloride) method, and confocal scanning laser microscopic (CSLM) observations have shown highly satisfactory antimicrobial and antibiofilm activity of the novel sparfoxacin (SPA)-treated urinary catheters compared with the controversial effectiveness of silver(Ag)-coated catheters against a background of untreated catheters used as controls. SPA-treated catheters were significantly less likely to become colonized (less than 0.01%; inner and outer surfaces against Escherichia coli and Staphylococcus aureus) than both silver-coated (from 0.01% to 39.3 %; outer surface against E. coli and inner surface against S. aureus, resp.) and untreated catheters (from 88.43% to 99.72%; outer and inner surfaces, resp., against S. aureus), and maintained their broad spectrum of antimicrobial and antibiofilm activity during storage for at least 6 months.
Department of Medicinal Chemistry, Medical University of Lublin, Lublin, Poland. dorota.kowalczuk@am.lublin.pl
Dorota
D
Kowalczuk
Grażyna
G
Ginalska
Tomasz
T
Piersiak
Małgorzata
M
Miazga-Karska
D000890:Anti-Infective Agents / Q000737:chemistry*; D018441:Biofilms / Q000254:growth & development*; D020099:Coated Materials, Biocompatible / Q000737:chemistry*; D004926:Escherichia coli / Q000502:physiology*; D008422:Materials Testing; D012834:Silver / Q000737:chemistry*; D013211:Staphylococcus aureus / Q000502:physiology*; D062885:Urinary Catheters
D000890:Anti-Infective Agents; D020099:Coated Materials, Biocompatible; D012834:Silver