Immune regulation and monitoring at the epithelial surface of the intestine.
The intestinal enterocytes and other epithelial cells create physical barriers, including tight junctions and mucus layers. These cells also actively transport antibodies across the epithelium and simultaneously produce antimicrobial peptides and enzymes. These functions maintain intestinal homeostasis by allowing the selective absorption of nutrients and simultaneously preventing pathogenic infections. Recent evidence has revealed that both host-derived factors (e.g., cytokines) and gut environmental factors (e.g., commensal bacteria, dietary materials, and their metabolites) regulate the physical and immunological functions of the epithelium. Understanding the interactions between host cells and these environmental factors should help us to develop new strategies to prevent and treat immune diseases of the intestine.
Division of Mucosal Immunology, Department of Microbiology and Immunology, Institute of Medical Science, The University of Tokyo, Tokyo, Japan. kunisawa@ims.u-tokyo.ac.jp
Jun
J
Kunisawa
Hiroshi
H
Kiyono
D000818:Animals; D000906:Antibodies / Q000378:metabolism; D001692:Biological Transport; D020895:Enterocytes / Q000378:metabolism; D006801:Humans; D007154:Immune System Diseases / Q000503:physiopathology / Q000628:therapy*; D007410:Intestinal Diseases / Q000276:immunology* / Q000628:therapy; D007413:Intestinal Mucosa / Q000276:immunology* / Q000382:microbiology; D019108:Tight Junctions / Q000378:metabolism
D000906:Antibodies