Nanoparticles and phage display selected peptides for imaging and therapy of cancer.
Molecular imaging probes are a special class of pharmaceuticals that target specific biochemical signatures associated with disease and allow for noninvasive imaging on the molecular level. Because changes in biochemistry occur before diseases reach an advanced stage, molecular imaging probes make it possible to locate and stage disease, track the effectiveness of drugs, treat disease, monitor response, and select patients to allow for more personalized diagnosis and treatment of disease. Targeting agents radiolabeled with positron emitters are of interest due to their ability to quantitatively measure biodistribution and receptor expression to allow for optimal dose determinations. (68)Ga is a positron emitter, which allows for quantitative imaging through positron emission chromatography (PET). The availability of (68)Ga from a generator and its ability to form stable complexes with a variety of chelates hold promise for expanding PET utilization to facilities unable to afford their own cyclotron. Nanoparticles conjugated with various proteins and peptides derived from phage display that can be selectively targeted are being developed and evaluated for guided imaging and therapy. Herein we highlight some initial efforts in combining the enhanced selectivity of nanoparticles and peptides with (68)Ga for use as molecular imaging probes.
Research Reactor Center, University of Missouri, Columbia, MO 65211-3400, USA. cutlerc@missouri.edu
Cathy S
CS
Cutler
Nripen
N
Chanda
Ravi
R
Shukla
Nebiat
N
Sisay
Melchor
M
Cantorias
Ajit
A
Zambre
Mark
M
McLaughlin
James
J
Kelsey
Anandhi
A
Upenandran
Dave
D
Robertson
Susan
S
Deutscher
Raghuraman
R
Kannan
Kattesh
K
Katti
D000512:Alpha Particles; D000818:Animals; D005710:Gallium Radioisotopes; D006046:Gold; D006801:Humans; D053768:Metal Nanoparticles / Q000627:therapeutic use; D009369:Neoplasms / Q000175:diagnosis* / Q000628:therapy; D019151:Peptide Library; D019275:Radiopharmaceuticals
D005710:Gallium Radioisotopes; D019151:Peptide Library; D019275:Radiopharmaceuticals; D006046:Gold