Systems biology for molecular life sciences and its impact in biomedicine.
Modern systems biology is already contributing to a radical transformation of molecular life sciences and biomedicine, and it is expected to have a real impact in the clinical setting in the next years. In this review, the emergence of systems biology is contextualized with a historic overview, and its present state is depicted. The present and expected future contribution of systems biology to the development of molecular medicine is underscored. Concerning the present situation, this review includes a reflection on the "inflation" of biological data and the urgent need for tools and procedures to make hidden information emerge. Descriptions of the impact of networks and models and the available resources and tools for applying them in systems biology approaches to molecular medicine are provided as well. The actual current impact of systems biology in molecular medicine is illustrated, reviewing two cases, namely, those of systems pharmacology and cancer systems biology. Finally, some of the expected contributions of systems biology to the immediate future of molecular medicine are commented.
Department of Molecular Biology and Biochemistry, University of Málaga, Malaga, Spain. medina@uma.es
Miguel Ángel
MÁ
Medina
D035843:Biomedical Research / Q000639:trends*; D053263:Gene Regulatory Networks / Q000502:physiology; D049673:History, 20th Century; D049674:History, 21st Century; D006801:Humans; D008954:Models, Biological; D008967:Molecular Biology / Q000639:trends*; D018919:Neovascularization, Physiologic / Q000502:physiology; D049490:Systems Biology / Q000266:history* / Q000379:methods* / Q000639:trends