Elevated glutathione peroxidase in newly diagnosed hypertension: its relation to insulin resistance.
Several studies have reported that insulin resistance and compensatory hyperinsulinemia often coexist with hypertension. Increased activity of glutathione peroxidase has been reported in patients with essential hypertension. Recently, overexpression of glutathione peroxidase has also been linked to the etiology of insulin resistance. The aim of this study was to determine the possible relation between the activity of glutathione peroxidase and insulin resistance status in essential hypertensive patients. A case-control study was performed on 35 hypertensive patients and 30 control subjects. The levels of insulin and insulin resistance as measured by the homeostasis model assessment insulin resistance index (HOMA-IR) and glutathione peroxidase were significantly increased in hypertensive patients compared with control subjects. In this study, a direct association was observed between glutathione peroxidase with HOMA-IR and insulin levels in essential hypertensive subjects. In conclusion, our results suggest that increased glutathione peroxidase can be one of the detrimental factors in contributing to insulin resistance in essential hypertensive subjects.
Department of Biochemistry, Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry, India.
Nambiar
N
Selvaraj
Viswanathan
V
Sathiyapriya
Zachariah
Z
Bobby
Hanumanthappa
H
Nandeesha
Agrawal
A
Aparna
D000328:Adult; D016022:Case-Control Studies; D057075:Enzyme Assays; D005979:Glutathione Peroxidase / Q000502:physiology*; D006801:Humans; D006973:Hypertension / Q000097:blood / Q000201:enzymology*; D007328:Insulin / Q000097:blood*; D007333:Insulin Resistance / Q000502:physiology*; D008875:Middle Aged; D018384:Oxidative Stress / Q000502:physiology
D007328:Insulin; D005979:Glutathione Peroxidase