[Regulation of innate immune responses by nucleic acid analogues].
The activation of innate immune responses by nucleic acids is critical to host responses against pathogens, such as viruses; however, nucleic acids can also trigger the development and/or exacerbation of pathogenic responses such as autoimmunity. We previously demonstrated that the selective activation of nucleic acid-sensing cytosolic and Toll-like receptors is contingent on the promiscuous sensing of nucleic acids by high-mobility group box proteins (HMGBs). Basides these findings, we also found that nonimmunogenic nucleotide with high-affinity HMGB binding, termed ISM ODN, functions as suppressing agent for nucleic acid-activated innate immune responses. In this review, we aim to summerize this novel feature of HMGB proteins in nucleic acid-mediated innate immune responses. In addition, we will discuss the inhibitory effect of nonimmunogenic oligodeoxynucleotides (ni-ODNs) targeting HMGB proteins.
Department of Immunology, Graduate School of Medicine and Faculty of Medicine, University of Tokyo. yanai@m.u-tokyo.ac.jp
Hideyuki
H
Yanai
D001327:Autoimmune Diseases / Q000276:immunology; D024002:HMGB Proteins / Q000502:physiology*; D006801:Humans; D007113:Immunity, Innate / Q000276:immunology*; D056747:Immunomodulation; D009696:Nucleic Acids / Q000502:physiology*; D009838:Oligodeoxyribonucleotides / Q000276:immunology; D051192:Receptors, Pattern Recognition / Q000502:physiology*; D015398:Signal Transduction / Q000502:physiology; D051193:Toll-Like Receptors / Q000502:physiology
D024002:HMGB Proteins; D009696:Nucleic Acids; D009838:Oligodeoxyribonucleotides; D051192:Receptors, Pattern Recognition; D051193:Toll-Like Receptors