Design, solvent free synthesis, and antimicrobial evaluation of 1,4 dihydropyridines.
Here in, we report the usage of cellulose sulfuric acid as a heterogeneous eco friendly catalyst for the synthesis of 1,4 dihydropyridines under solvent free conditions via Hantzsch three component reaction of an aldehyde, ethyl acetoacetate and ammonium acetate at 100 °C for 2-5 h. In silico studies were performed on twenty two possible 1,4 dihydropyridines (DHPs) analogues against K(+) channel receptor (KcsA). In order to validate in silico studies, thirteen compounds were synthesized and evaluated as antibacterials against twenty seven ESBL isolates of Klebsiella pneumoniae and Escherichia coli.
Department of Organic Chemistry, Foods, Drugs & Water, Andhra University, Visakhapatnam 530003, India. murthyyln@yahoo.co.in
Y L N
YL
Murthy
Abdul
A
Rajack
Taraka Ramji
TR
Moturu
J
J
Jeson babu
Ch
Ch
Praveen
K
K
Aruna Lakshmi
D000900:Anti-Bacterial Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D004095:Dihydropyridines / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D015195:Drug Design; D004926:Escherichia coli / Q000187:drug effects*; D006860:Hydrogen Bonding; D007711:Klebsiella pneumoniae / Q000187:drug effects*; D008826:Microbial Sensitivity Tests; D008958:Models, Molecular; D015394:Molecular Structure; D013329:Structure-Activity Relationship
D000900:Anti-Bacterial Agents; D004095:Dihydropyridines; C038806:1,4-dihydropyridine