Sickle cell disease and leg ulcers.
Sickle cell disease is a genetic disorder of hemoglobin synthesis leading to a deformation of the red blood cell. This disorder is associated with painful, slow-to-heal leg ulcers. This article discusses the wound bed preparation paradigm as a guide to the treatment of sickle cell-associated leg ulcers.
Duke University Medical Center, Durham, North Carolina, USA.
Barry
B
Ladizinski
Andrea
A
Bazakas
Nisha
N
Mistry
Afsaneh
A
Alavi
R Gary
RG
Sibbald
Richard
R
Salcido
D000755:Anemia, Sickle Cell / Q000150:complications* / Q000503:physiopathology / Q000628:therapy; D001803:Blood Transfusion / Q000379:methods*; D058128:Compression Bandages; D003646:Debridement; D006454:Hemoglobins / Q000032:analysis; D006801:Humans; D006918:Hydroxyurea / Q000627:therapeutic use; D007871:Leg Ulcer / Q000209:etiology* / Q000503:physiopathology / Q000628:therapy; D014945:Wound Healing / Q000187:drug effects / Q000502:physiology*; D014946:Wound Infection / Q000628:therapy*
D006454:Hemoglobins; D006918:Hydroxyurea