[Adverse perinatal outcomes in Mexican women with twin pregnancy achieved by assisted reproduction techniques vs. spontaneous twin pregnancies].
BACKGROUND
Twin pregnancies (TP) have shown a greater risk of adverse perinatal outcomes than singletons have. However, there is still no consensus about whether the TP achieved by assisted reproduction techniques (ART) have worse perinatal outcomes compared with TP achieved spontaneously.


OBJECTIVE
Compare the incidence of adverse perinatal outcomes (preterm birth, premature rupture of membranes, gestational diabetes, pregnancy-induced hypertension, anemia, weight and destination of the newborn) in Mexican women with TP achieved spontaneously vs those with TP achieved by ART.


METHODS
Historical cohort study with two sample groups: group 1, women with TP achieved spontaneously, and group 2, women with TP achieved by ART. Women with TP achieved by TRA were matched 1:1 with women with EG achieved spontaneously for age, weeks of gestation, chorionicity and body mass index at admission to prenatal care. Adverse perinatal outcomes were compared between the two groups and the odds ratio (OR) had a 95% confidence interval.


RESULTS
There were 57 women per group. Baseline characteristics were similar in both groups except for nulliparity (38.6% in group 1 vs 82.5% in group 2 (p < 0.0001)). In group 2 there was a higher incidence of pregnancy-induced hypertension (group 1 (19.3%) vs. group 2 (42.1%), OR 2.5 (95% CI 1.07-5.8)). Newborns in group 2 were admitted to nursery more often than those in group 1 (49.1% vs. 35.1% OR 1.7 IC 95% 1.04-3.04). There was no difference in other adverse perinatal outcomes.


CONCLUSIONS
Mexican women with TP achieved by ART had higher risk of pregnancy-induced hypertension compared to women with TP achieved spontaneously.
Departamento de Tococirurgía y Urgencias, Instituto Nacional de Parinatología Isidro Espinosa de los Reyes, DF México.
Jorge
J
Beltrán Montoya
Enrique
E
Reyes Muñoz
Eduardo
E
Cruz Rivera
Berenice
B
López Villaseñor
Julio
J
Francisco de la Jara Díaz
Tomás
T
Herrerías Canedo
D000328:Adult; D005260:Female; D006801:Humans; D008800:Mexico; D011247:Pregnancy; D011256:Pregnancy Outcome; D059285:Pregnancy, Twin; D027724:Reproductive Techniques, Assisted / Q000009:adverse effects*