Sodium sulfite enhances rhinovirus-induced chemokine production in airway epithelial cells.
We investigated the effects of sodium sulfite (Na(2)SO(3)) on rhinovirus (RV)-induced chemokine production in A549 airway epithelial cells. Our results demonstrated that the treatment of A549 cells with 2,500 μM Na(2)SO(3) enhanced the mRNA expression of RV-induced interleukin (IL)-8 1.8 fold (p = 0.025); and regulated on activation, normal T cell expressed and secreted (RANTES), 2.9 fold (p = 0.025). Moreover, the secretion of IL-8, RANTES, and interferon-γ-inducible protein (IP)-10 was increased in a statistically significant manner without affecting cell viability and RV replication. Our results suggest that Na(2)SO(3) may potentiate RV infection by enhancing chemokine production.
Department of Pediatrics, School of Medicine, The Catholic University of Korea, 505 Banpo-dong, Seocho-gu, Seoul 137-701, Republic of Korea.
Yoon Hong
YH
Chun
Hyun Sook
HS
Kim
Huisu
H
Lee
Sulmui
S
Won
Jong-seo
JS
Yoon
Hyun Hee
HH
Kim
Jin Tack
JT
Kim
Joon Sung
JS
Lee
D000393:Air Pollutants / Q000633:toxicity*; D002460:Cell Line; D018925:Chemokines / Q000378:metabolism*; D004847:Epithelial Cells / Q000378:metabolism*; D006801:Humans; D016209:Interleukin-8 / Q000378:metabolism; D012229:Rhinovirus / Q000187:drug effects* / Q000502:physiology; D013447:Sulfites / Q000633:toxicity*
D000393:Air Pollutants; D018925:Chemokines; D016209:Interleukin-8; D013447:Sulfites; C025026:sodium sulfite