Sensing mitochondrial homeostasis: the protein import machinery takes control.
Mitochondrial homeostasis is maintained by several quality control mechanisms, including an unfolded protein response that in turn elicits a transcriptional response. In a recent issue of Science, Nargund et al. (2012) propose a sensing mechanism for unfolded proteins' accumulation in the mitochondrial matrix that involves the mitochondrial protein import machinery.
Institut für Biochemie und Molekularbiologie, ZBMZ and BIOSS Centre for Biological Signalling Studies, Universität Freiburg, 79104 Freiburg, Germany.
F-Nora
FN
Vögtle
Chris
C
Meisinger