Clinicopathological analysis of rhabdoid meningiomas: report of 12 cases and a systematic review of the literature.
BACKGROUND
Rhabdoid meningioma (RM) is a rare subtype of meningioma, classified as World Health Organization grade III with a poor prognosis. Here we present our experience on RM and review relevant literature in an attempt to investigate the clinical features, treatment, and prognosis of these tumors.


METHODS
Twelve patients underwent surgical treatment for intracranial RMs between 2003 and 2008 in our department. The clinical data, radiological manifestations, pathological findings, treatments, and prognoses of the patients were analyzed retrospectively; 58 other cases reported previously by other institutions also were summarized and reviewed.


RESULTS
These cases (6 men and 6 women, mean age 44.3 years old, ranging from 21 to 78 years old) constituted 0.28% of all meningioma patients admitted at our department during the same period. The mean duration of symptoms was relatively short at 1.6 months. There was no significant clinical manifestation noted, and the radiologic findings fell into 3 types of images. In the follow-up period of over 30 months, 7 patients died; 5 patients had recurrence and 2 patients died of unknown causes.


CONCLUSIONS
RM is a rare subtype of malignant meningioma featuring an increased tendency for recurrence and possible metastasis. It is still difficult to make a correct preoperative diagnosis. The overall prognosis for these patients is extremely poor, and the role of various adjuvant treatments needs to be further studied.
Department of Neurosurgery, Huashan Hospital of Fudan University, Shanghai, People's Republic of China.
Yu
Y
Zhou
Qing
Q
Xie
Ye
Y
Gong
Ying
Y
Mao
Ping
P
Zhong
Xiaoming
X
Che
Chengchuan
C
Jiang
Fengping
F
Huang
Kang
K
Zheng
Shiqi
S
Li
Yuxiang
Y
Gu
Weimin
W
Bao
Bojie
B
Yang
Jinsong
J
Wu
Yin
Y
Wang
Hong
H
Chen
Liqian
L
Xie
Mingzhe
M
Zheng
Hailiang
H
Tang
Daijun
D
Wang
Hongda
H
Zhu
Xiancheng
X
Chen
D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008577:Meningeal Neoplasms / Q000175:diagnosis* / Q000401:mortality / Q000473:pathology / Q000601:surgery*; D008579:Meningioma / Q000175:diagnosis* / Q000401:mortality / Q000473:pathology / Q000601:surgery*; D008875:Middle Aged; D060787:Neoplasm Grading; D009364:Neoplasm Recurrence, Local / Q000175:diagnosis / Q000401:mortality / Q000473:pathology / Q000601:surgery; D011183:Postoperative Complications / Q000175:diagnosis / Q000401:mortality; D011379:Prognosis; D012086:Reoperation; D012189:Retrospective Studies; D016019:Survival Analysis; D055815:Young Adult