Thrombophilia and damage of kidney during pregnancy.
OBJECTIVE
It's known that heritable thrombophilias are a risk factor for the development of obstetrics complications associated to inadequate uterine-placental circulation, as pre-eclampsia/eclampsia, HELLP syndrome, placental abruption and intrauterine growth restriction (IUGR), however it was never investigated the role that they could have in the renal failure associated to such conditions. The purpose of this study is to evaluate if thrombophilia itself that predispose to a possible renal damage or if its occurrence determines a more severe involvement of the kidneys in the course of these obstetric pathologies.


METHODS
In the study were enrolled 301 pregnant women, who carried a thrombophilic state, 125 of whom (B group) has had an obstetric complication. In all the women the renal function was assessed taking into consideration proteinuria, creatininaemia and hypalbuminaemia.


RESULTS
Of the three parameters which have been considered as evidence of a severe renal involvement the hypalbuminaemia appears statistically significant compared to the controls. Even creatinaemia is significantly increased in pregnant women with an Anthithrombin deficiency, and increased levels are detected in women with Factor V Leiden.


CONCLUSIONS
In obstetric complications associated to thrombophilic state could be a more severe involvement of the kidney.
Department of Obstetrics and Gynaecology, Fatebenefratelli Isola Tiberina Hospital, Rome.
Larciprete
L
Giovanni
Liumbruno Giancarlo
LG
Maria
Rongioletti
R
Mauro
Montagnoli
M
Carlotta
Rossi
R
Federica
Papa
P
Fabrizio
Jarvis
J
Sheba
Di Pierro
DP
Giuseppe
Bompiani
B
Alessandro
Cirese
C
Elio
Valensise
V
Herbert