Efficacy of nanoporous silica coatings on middle ear prostheses as a delivery system for antibiotics: an animal study in rabbits.
Nanoporous silica layers are able to host molecules and release them over a certain period of time. These local drug delivery systems for antibiotics could be a new approach in the treatment of chronic otitis media. The aim of this study was to examine the efficacy of nanoporous silica coatings on middle ear prostheses as a delivery system for antibiotics in vivo. Pseudomonas aeruginosa was inoculated into the middle ear of rabbits to induce an otitis media. The control group received coated Bioverit®II implants without antibiotics. Coated prostheses with loaded ciprofloxacin were implanted into the middle ears of the study group. After 1 week, the rabbits were sacrificed. The clinical examination as well as the microbiological and histological examinations of organs and middle ear irrigation revealed clear differences between the two groups. P. aeruginosa was detected in every middle ear of the control group and was almost completely eliminated in the study group. Organ examinations revealed the presence of P. aeruginosa in the control group and a prevention of a bacterial spread in the study group. The nanoporous silica layer as antibiotic delivery system showed convincing efficacy in induced pseudomonal otitis media in the rabbit.
Department of Otolaryngology, Hannover Medical School, Hannover, Germany. Lensing.Rebecca@mh-hannover.de
Rebecca
R
Lensing
André
A
Bleich
Anna
A
Smoczek
Silke
S
Glage
Nina
N
Ehlert
Tammo
T
Luessenhop
Peter
P
Behrens
Peter Paul
PP
Müller
Manfred
M
Kietzmann
Martin
M
Stieve
D000818:Animals; D000900:Anti-Bacterial Agents / Q000008:administration & dosage* / Q000494:pharmacology; D015169:Colony Count, Microbial; D016503:Drug Delivery Systems; D004432:Ear, Middle / Q000601:surgery; D005260:Female; D008826:Microbial Sensitivity Tests; D053758:Nanoparticles; D019736:Prostheses and Implants; D011550:Pseudomonas aeruginosa / Q000187:drug effects; D011817:Rabbits; D012822:Silicon Dioxide
D000900:Anti-Bacterial Agents; D012822:Silicon Dioxide