Dietary methionine and n-6/n-3 polyunsaturated fatty acid ratio reduce adverse effects of infectious bursal disease in broilers.
This study was carried out to investigate the modulatory effects of dietary methionine and n-6/n-3 polyunsaturated fatty acids (PUFA) ratio on immune response and performance of infectious bursal disease (IBD)-challenged broiler chickens. In total, 350 one-day-old male broiler chicks were assigned to 1 of the 6 dietary treatment groups in a 3 × 2 factorial arrangement. There were 3 n-6/n-3 PUFA ratios (45, 5.5, and 1.5) and 2 levels of methionine (NRC recommendation and twice NRC recommendation). The results showed that birds fed with dietary n-6/n-3 PUFA ratio of 5.5 had higher BW, lower feed intake, and superior FCR than other groups. However, the highest antibody response was observed in birds with dietary n-6/n-3 PUFA ratio of 1.5. Lowering n-6/n-3 PUFA ratio reduced bursa lesion score equally in birds fed with n-6/n-3 PUFA ratio of 5.5 and 1.5. Supplementation of methionine by twice the recommendation also improved FCR and reduced feed intake and bursa lesion score. However, in this study, the optimum performance (as measured by BW, feed intake, and FCR) did not coincide with the optimum immune response (as measured by antibody titer). It seems that dietary n-3 PUFA modulates the broiler chicken performance and immune response in a dose-dependent but nonlinear manner. Therefore, it can be suggested that a balance of moderate level of dietary n-6/n-3 PUFA ratio (5.5) and methionine level (twice recommendation) might enhance immune response together with performance in IBD-challenged broiler chickens.
Department of Animal Science, Universiti Putra Malaysia, 43400 UPM Serdang, Selangor, Malaysia.
E
E
Maroufyan
A
A
Kasim
M
M
Ebrahimi
T C
TC
Loh
M
M
Hair-Bejo
A F
AF
Soleimani
D000821:Animal Feed; D000824:Animal Nutritional Physiological Phenomena; D000818:Animals; D018175:Birnaviridae Infections / Q000178:diet therapy / Q000662:veterinary* / Q000821:virology; D002645:Chickens; D004032:Diet / Q000662:veterinary; D019587:Dietary Supplements; D015525:Fatty Acids, Omega-3 / Q000008:administration & dosage / Q000494:pharmacology*; D043371:Fatty Acids, Omega-6 / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology*; D005395:Fish Oils / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology; D007243:Infectious bursal disease virus; D008221:Lymphoid Tissue / Q000187:drug effects; D008297:Male; D008715:Methionine / Q000494:pharmacology*; D010938:Plant Oils / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology; D011201:Poultry Diseases / Q000517:prevention & control; D000074242:Sunflower Oil
D015525:Fatty Acids, Omega-3; D043371:Fatty Acids, Omega-6; D005395:Fish Oils; D010938:Plant Oils; D000074242:Sunflower Oil; D008715:Methionine