First trimester assessment of pentraxin-3 levels in women with primary unexplained recurrent pregnancy loss.
OBJECTIVE
To evaluate the potential role of measuring first-trimester maternal Pentraxin-3 levels in patients with primary unexplained recurrent pregnancy loss.


METHODS
A case control study was conducted in Ain Shams University Maternity Hospital. Cases included 45 women with primary unexplained recurrent pregnancy loss and early pregnancy failure admitted for medical or surgical termination of pregnancy. Controls (45 women) included a matched group of apparently healthy pregnant women who had at least one previous uneventful pregnancy with no previous obstetric history of adverse pregnancy outcomes. Maternal venous blood samples were collected for assay of Pentraxin-3 using enzyme-linked immunosorbent assay. The main outcome measure was the pregnancy outcome in women with elevated Pentraxin-3 levels.


RESULTS
90 participants were statistically analyzed. In the patient group, the mean Pentraxin-3 level was 12.00 ± 4.07 ng/ml, while in the control group it was 1.69 ± 0.91 ng/ml. The difference was statistically significant (p<0.001). In the patient group, Pentraxin-3 showed a significant positive correlation with the number of previous miscarriages (p=0.038).


CONCLUSIONS
Abnormally elevated Pentraxin-3 levels indicate the presence of an abnormally exaggerated intrauterine inflammatory or innate immune response that may cause pregnancy failure in women with primary unexplained recurrent pregnancy loss.
Obstetrics & Gynecology Department, Ain Shams Faculty of Medicine, Cairo, Egypt.
Moustafa Ibrahim
MI
Ibrahim
Hisham Mahmoud
HM
Harb
Mohamed Ibrahem
MI
Ellaithy
Rania Hamdy
RH
Elkabarity
Marwa Hussein
MH
Abdelgwad
D000026:Abortion, Habitual / Q000097:blood* / Q000276:immunology; D000328:Adult; D015415:Biomarkers / Q000097:blood; D002097:C-Reactive Protein / Q000032:analysis*; D016022:Case-Control Studies; D004534:Egypt; D020964:Embryo Loss / Q000097:blood* / Q000276:immunology; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D005500:Follow-Up Studies; D006771:Hospitals, Maternity; D006785:Hospitals, University; D006801:Humans; D010044:Outpatient Clinics, Hospital; D010865:Pilot Projects; D011247:Pregnancy; D011261:Pregnancy Trimester, First; D012008:Recurrence; D000683:Serum Amyloid P-Component / Q000032:analysis*; D015854:Up-Regulation; D000099153:Pentraxins
D015415:Biomarkers; D002097:C-Reactive Protein; D000683:Serum Amyloid P-Component; D000099153:Pentraxins