Association of dopaminergic/GABAergic genes with attention deficit hyperactivity             disorder in children.
Attention deficit hyperactivity disorder (ADHD) is the most commonly diagnosed             neurobehavioral disorder in children and adolescents; however, its etiology is             unknown. In this study, we investigated the association of five polymorphisms             in dopaminergic/GABAergic genes with ADHD using polymerase chain reaction-restriction             fragment length polymorphism in a group of 54 children with ADHD and 67 healthy             controls. The distribution of AA genotype and A allele frequencies of rs5320 in             the dopamine beta-hydroxylase gene in ADHD children differed significantly from             that in healthy controls; however, no associations were found between four other             polymorphisms in dopaminergic/GABAergic genes and ADHD. We also identified the             best model consisting of four loci. We conclude that the rs5320 polymorphism may             be considered as a genetic risk factor of ADHD, but the other four polymorphisms             were not confirmed to be related directly to ADHD. The multilocus of dopaminergic/GABAergic             genes acted in combination to affect susceptibility to ADHD in the children studied.
Medical Institute of Paediatrics, Qilu Children's Hospital of Shandong University, Jinan, Shandong 250022, PR China.
Guang-Xin
GX
Wang
Yan-Hui
YH
Ma
Shi-Fu
SF
Wang
Guang-Fang
GF
Ren
Hui
H
Guo
D000293:Adolescent; D001289:Attention Deficit Disorder with Hyperactivity / Q000235:genetics*; D002394:Catechol O-Methyltransferase / Q000235:genetics; D002648:Child; D004299:Dopamine beta-Hydroxylase / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D008297:Male; D011110:Polymorphism, Genetic; D017447:Receptors, Dopamine D1 / Q000235:genetics; D017448:Receptors, Dopamine D2 / Q000235:genetics; D018080:Receptors, GABA-B / Q000235:genetics; D012307:Risk Factors
D017447:Receptors, Dopamine D1; D017448:Receptors, Dopamine D2; D018080:Receptors, GABA-B; D004299:Dopamine beta-Hydroxylase; D002394:Catechol O-Methyltransferase