Babesia ovis infections: detailed clinical and laboratory observations in the pre- and post-treatment periods of 97 field cases.
Ovine babesiosis, caused by Babesia ovis, is of major economic importance in Turkey. The changes in the blood profile of infected animals are informative about the course of infection. The aim of the present study was to evaluate the hematological and biochemical changes in the pre- and post-treatment periods of the natural B. ovis infections. The presence of the parasites was confirmed by microscopy and polymerase chain reaction (PCR) analysis. On the basis of the clinical and laboratory findings, the infections were categorized into different groups according to the degree of anemia and the level of parasitemia. All infected sheep were treated with imidocarb dipropionate (IMDP). The blood pictures in the pre- and post-treatment periods were compared. Pancytopenia occurred in animals with severe anemia and very high parasitemia, and bicytopenia in the other groups. The platelet count (PLT), plateletcrit (PCT) and mean platelet volume (MPV) returned to the normal ranges after treatment, except those in the group with severe anemia. In the biochemical profile, B. ovis infection caused an increase in blood urea nitrogen and total bilirubin, and these parameters returned to normal levels after treatment. The indirect fluorescein antibody test (IFAT) results showed that 38.1% of the cases raised specific antibodies during the period of infection, with titers ranging from 1/160 to 1/640. All of 45 animals re-examined after treatment were seropositive, with high titers that rose up to 1/5120.
University of Selcuk, Faculty of Veterinary Medicine, Department of Parasitology, Konya, Turkey. fsevinc@selcuk.edu.tr
Ferda
F
Sevinc
Mutlu
M
Sevinc
Ozlem Derinbay
OD
Ekici
Ramazan
R
Yildiz
Nermin
N
Isik
Ugur
U
Aydogdu
D000740:Anemia / Q000662:veterinary*; D000818:Animals; D001403:Babesia; D001404:Babesiosis / Q000188:drug therapy* / Q000473:pathology / Q000662:veterinary*; D001772:Blood Cell Count; D001774:Blood Chemical Analysis; D007095:Imidocarb / Q000031:analogs & derivatives* / Q000627:therapeutic use; D018512:Parasitemia / Q000188:drug therapy / Q000473:pathology / Q000662:veterinary*; D012756:Sheep; D012757:Sheep Diseases / Q000188:drug therapy* / Q000473:pathology*; D014421:Turkey
D007095:Imidocarb; C031719:imidocarb dipropionate