HCRP1 expression status is a significant prognostic marker in oral and oropharyngeal cancer.
OBJECTIVE
The hepatocellular carcinoma-related protein 1 (HCRP1) is a key factor in the degradation of the epidermal growth factor receptor. In this study, we assessed the prognostic significance of HCRP1 expression in patients with oral and oropharyngeal squamous cell carcinoma (OOSCC).


METHODS
HCRP1 expression was determined by immunohistochemistry on tissue biopsy sections of 111 patients with locally advanced OOSCC undergoing neoadjuvant chemoradiotherapy followed by surgery. The Kaplan-Meier method and Cox regression models were used for survival analyses.


RESULTS
Low HCRP1 expression was associated with poor recurrence-free survival (P = 0.046) and overall survival (P = 0.03). Multivariate analysis revealed that low HCRP1 expression remained an independent risk factor for relapse (HR 2.98, 95% CI 1.19-7.49, P = 0.02) and death (HR 3.04, 95% CI 1.19-7.79, P = 0.02).


CONCLUSIONS
Low HCRP1 expression was found to be of adverse prognostic significance in patients with OOSCC who received preoperative chemoradiotherapy.
Departments of Cranio-, Maxillofacial and Oral Surgery, Medical University of Vienna, Vienna, Austria.
C
C
Perisanidis
B
B
Savarese-Brenner
T
T
Würger
F
F
Wrba
A
A
Huynh
C
C
Schopper
G
G
Kornek
E
E
Selzer
R
R
Ewers
A
A
Psyrri
M
M
Krainer
M
M
Filipits
D000328:Adult; D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000235:genetics* / Q000401:mortality / Q000628:therapy; D059248:Chemoradiotherapy; D056827:Endosomal Sorting Complexes Required for Transport / Q000235:genetics*; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D008297:Male; D008875:Middle Aged; D009062:Mouth Neoplasms / Q000235:genetics* / Q000401:mortality / Q000628:therapy; D009959:Oropharyngeal Neoplasms / Q000235:genetics* / Q000401:mortality / Q000628:therapy; D011379:Prognosis; D012189:Retrospective Studies; D015996:Survival Rate; D055815:Young Adult
D056827:Endosomal Sorting Complexes Required for Transport; C496437:VPS37A protein, human