PlGF: a multitasking cytokine with disease-restricted activity.
Placental growth factor (PlGF) is a member of the vascular endothelial growth factor (VEGF) family that also comprises VEGF-A (VEGF), VEGF-B, VEGF-C, and VEGF-D. Unlike VEGF, PlGF is dispensable for development and health but has diverse nonredundant roles in tissue ischemia, malignancy, inflammation, and multiple other diseases. Genetic and pharmacological gain-of-function and loss-of-function studies have identified molecular mechanisms of this multitasking cytokine and characterized the therapeutic potential of delivering or blocking PlGF for various disorders.
Laboratory of Angiogenesis and Neurovascular Link, VIB Vesalius Research Center, K.U. Leuven, Leuven, Belgium.
Mieke
M
Dewerchin
Peter
P
Carmeliet
D000818:Animals; D001172:Arthritis, Rheumatoid / Q000188:drug therapy; D002318:Cardiovascular Diseases / Q000188:drug therapy / Q000209:etiology; D003092:Colitis / Q000209:etiology; D016207:Cytokines / Q000037:antagonists & inhibitors / Q000172:deficiency / Q000235:genetics / Q000502:physiology*; D048788:Growth and Development / Q000502:physiology; D006402:Hematologic Diseases / Q000188:drug therapy / Q000209:etiology; D006801:Humans; D006968:Hypersensitivity, Delayed / Q000188:drug therapy; D008103:Liver Cirrhosis / Q000188:drug therapy; D051379:Mice; D009369:Neoplasms / Q000188:drug therapy / Q000209:etiology; D009765:Obesity / Q000188:drug therapy; D000072483:Placenta Growth Factor; D011257:Pregnancy Proteins / Q000037:antagonists & inhibitors / Q000172:deficiency / Q000235:genetics / Q000502:physiology*; D011656:Pulmonary Emphysema / Q000188:drug therapy; D018805:Sepsis / Q000209:etiology; D015398:Signal Transduction / Q000502:physiology; D040281:Vascular Endothelial Growth Factor Receptor-1 / Q000502:physiology; D014945:Wound Healing / Q000502:physiology
D016207:Cytokines; C000608036:PGF protein, human; C000608037:Pgf protein, mouse; D011257:Pregnancy Proteins; D000072483:Placenta Growth Factor; C501162:FLT1 protein, human; D040281:Vascular Endothelial Growth Factor Receptor-1