Intravascular atherosclerotic imaging with combined fluorescence and optical coherence tomography probe based on a double-clad fiber combiner.
We developed a multimodality fluorescence and optical coherence tomography probe based on a double-clad fiber (DCF) combiner. The probe is composed of a DCF combiner, grin lens, and micromotor in the distal end. An integrated swept-source optical coherence tomography and fluorescence intensity imaging system was developed based on the combined probe for the early diagnoses of atherosclerosis. This system is capable of real-time data acquisition and processing as well as image display. For fluorescence imaging, the inflammation of atherosclerosis and necrotic core formed with the annexin V-conjugated Cy5.5 were imaged. Ex vivo imaging of New Zealand white rabbit arteries demonstrated the capability of the combined system.
Dalian University of Technology, School of Physics and Optoelectronic Engineering, Ganjingzi District, Dalian City, Liaoning Province, China.
Shanshan
S
Liang
Arya
A
Saidi
Joe
J
Jing
Gangjun
G
Liu
Jiawen
J
Li
Jun
J
Zhang
Changsen
C
Sun
Jagat
J
Narula
Zhongping
Z
Chen
D000792:Angiography / Q000295:instrumentation*; D000818:Animals; D050197:Atherosclerosis / Q000175:diagnosis*; D057510:Endovascular Procedures / Q000295:instrumentation*; D004867:Equipment Design; D019544:Equipment Failure Analysis; D005336:Fiber Optic Technology / Q000295:instrumentation*; D008856:Microscopy, Fluorescence / Q000295:instrumentation*; D011817:Rabbits; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D013382:Subtraction Technique / Q000295:instrumentation*; D041623:Tomography, Optical Coherence / Q000295:instrumentation*; D014159:Transducers