Meta-analysis  demonstrates that the NAD(P)H: quinone oxidoreductase 1 (NQO1) gene 609  C>T polymorphism is associated with increased gastric cancer risk in Asians.
The  association between the NAD(P)H: quinone oxidoreductase 1 (NQO1) gene  C609T polymorphism and gastric cancer has been widely evaluated, yet with  conflicting results. Data were available from seven study populations involving  2600 subjects. Overall, comparison of alleles 609T and 609C indicated a significantly  increased risk (46%) for gastric cancer (95% confidence interval (95%CI) for  odds ratio (OR) = 1.20-1.79) in individuals with the T allele. The tendency was  increased in the homozygous comparison (609TT versus 609CC), with an OR = 2.04  (95%CI = 1.37-3.05). Stratified analysis by study design demonstrated stronger  associations in population-based studies than in hospital-based studies, based  on OR. Ethnicity-based analysis demonstrated a significant association in  Asians but not in Caucasians. Additionally, in the subgroup analyses by the  type of gastric cancer, a significantly increased risk was found with all  genetic models in the gastric adenocarcinoma subgroup compared to the others.  We conclude that the NQO1 gene C609T polymorphism increases the risk for  gastric cancer, especially in Asian populations.
Department of Gastroenterology, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.
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D044466:Asian People / Q000235:genetics*; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006801:Humans; D016660:NAD(P)H Dehydrogenase (Quinone) / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D012307:Risk Factors; D013274:Stomach Neoplasms / Q000145:classification / Q000201:enzymology* / Q000235:genetics*
D016660:NAD(P)H Dehydrogenase (Quinone); C447479:NQO1 protein, human