Cycloaromatization protocol for synthesis of polysubstituted phenol derivatives: method development and mechanistic studies.
The scope of the cycloaromatization of propargylic ethers was explored using operationally simple air- and moisture-insensitive conditions. Highly substituted phenol derivatives were obtained in high yields. Mechanistic experiments indicate that the reaction occurs by an electrocyclization followed by 1,3-proton transfer.
Department of Chemistry, University of Rochester, Rochester, New York 14627, USA.
William T
WT
Spencer
Alison J
AJ
Frontier
D003500:Cyclization; D015394:Molecular Structure; D010636:Phenols / Q000138:chemical synthesis* / Q000737:chemistry; D013237:Stereoisomerism
D010636:Phenols