Remineralization models.
During the ICNARA 2 conference, a workshop was held on remineralization models. The group considered the role of remineralization models, whether there was one ideal in situ model design, what essential features should be incorporated into an in situ model, other alternative models, and what new methods for measuring remineralization were on the horizon. This paper summarizes the discussion. In situ and other caries models can be used as a surrogate for caries clinical trials but only when data exist to validate the model. In situ model design should be flexible to allow for investigation of different aspects of the caries process; however, several essential features were identified that should be incorporated into the study design. A range of other caries models was discussed, including the study of non-cavitated lesions, lesions post-orthodontic therapy, plaque retention models to form more standardized lesions, and the study of root caries lesions. Numerous new methods for quantifying remineralization were discussed, but it was considered that these require validation before they can be used in clinical trials.
Oral Health Cooperative Research Centre, Melbourne Dental School, Bio 21 Institute, The University of Melbourne, Melbourne, Australia.
N J
NJ
Cochrane
D T
DT
Zero
E C
EC
Reynolds
D002986:Clinical Trials as Topic; D003731:Dental Caries / Q000503:physiopathology / Q000628:therapy; D018865:Dental Research / Q000592:standards*; D006801:Humans; D008954:Models, Biological; D012107:Research Design / Q000592:standards*; D014089:Tooth Remineralization / Q000379:methods*