Flavonoid intake and bone health.
Flavonoids, found in a wide diversity of plant foods from fruits and vegetables, herbs and spices, essential oils, and beverages, have the most potential of dietary components for promotion of bone health beyond calcium and vitamin D. Recent epidemiological studies show flavonoid consumption to have a stronger association with bone than general fruit and vegetable consumption. Bioactive flavonoids are being assessed for properties beyond their chemical antioxidant capacity, including anti-inflammatory actions. Some have been reported to enhance bone formation and to inhibit bone resorption through their action on cell signaling pathways that influence osteoblast and osteoclast differentiation. Future research is needed to determine which of the flavonoids and their metabolites are most effective and at what dose, as well as the mechanism of modulating cellular events, in order to set priorities for clinical trials.
Department of Nutrition Science, Purdue University, West Lafayette, Indiana 47907-2059, USA. weavercm@purdue.edu
Connie M
CM
Weaver
D Lee
DL
Alekel
Wendy E
WE
Ward
Martin J
MJ
Ronis
D000893:Anti-Inflammatory Agents / Q000494:pharmacology / Q000627:therapeutic use; D001862:Bone Resorption / Q000517:prevention & control*; D001842:Bone and Bones / Q000166:cytology / Q000187:drug effects*; D004032:Diet; D005419:Flavonoids / Q000494:pharmacology / Q000627:therapeutic use*; D006801:Humans; D010006:Osteoblasts / Q000166:cytology / Q000187:drug effects; D010010:Osteoclasts / Q000166:cytology / Q000187:drug effects; D010012:Osteogenesis / Q000187:drug effects; D010024:Osteoporosis / Q000517:prevention & control*; D008517:Phytotherapy; D010936:Plant Extracts / Q000494:pharmacology / Q000627:therapeutic use*; D015398:Signal Transduction / Q000187:drug effects
D000893:Anti-Inflammatory Agents; D005419:Flavonoids; D010936:Plant Extracts