Evaluation of microcrystalline cellulose II (MCCII) as an alternative extrusion-spheronization aid.
Microcrystalline cellulose II (MCCII) is a different allomorph of MCC that can be used as a filler and a disintegrant for direct compression. MCCII was studied as new pelletization aid with the aim to prepare pellets with a faster drug release than MCCI-based pellets. MCCII-based pellets showed an immediate diphenydramineHCl release profile comparable to that of Benadryl and a faster griseofulvin release than MCCI-based pellets. MCCII offers potential to use as an alternative pelletization aid.
Department of Pharmacy, School of Pharmaceutical Chemistry, The University of Antioquia, Medellin, Colombia. jrojasca@gmail.com
J
J
Rojas
V
V
Kumar
D000465:Algorithms; D002214:Capsules; D002482:Cellulose / Q000737:chemistry*; D002626:Chemistry, Pharmaceutical; D004155:Diphenhydramine / Q000737:chemistry; D004339:Drug Compounding; D005079:Excipients / Q000737:chemistry*; D006118:Griseofulvin / Q000737:chemistry; D007700:Kinetics; D008863:Microspheres; D010316:Particle Size; D016062:Porosity; D011461:Prostaglandins F, Synthetic; D012995:Solubility
D002214:Capsules; D005079:Excipients; D011461:Prostaglandins F, Synthetic; D006118:Griseofulvin; D004155:Diphenhydramine; D002482:Cellulose; C049643:luprostenol; C109691:microcrystalline cellulose