Palladium-assisted regioselective C-H cyanation of heteroarenes using isonitrile as cyanide source.
A palladium-catalyzed regioselective C-H cyanation of heteroarenes was achieved using tert-butyl isocyanide as "CN" source, which provides a new and unique strategy for the preparation of (hetero)aryl nitriles. Indoles, pyrroles, and aromatic rings could be efficiently cyanated through C-H bond activation with high regioselectivity.
Department of Chemistry, Shanghai University, Shanghai 200444, China.
Shuguang
S
Xu
Xiaomei
X
Huang
Xiaohu
X
Hong
Bin
B
Xu
D002384:Catalysis; D007211:Indoles / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D009570:Nitriles / Q000138:chemical synthesis* / Q000737:chemistry; D010165:Palladium / Q000737:chemistry*; D011725:Pyridines / Q000737:chemistry; D011743:Pyrimidines / Q000737:chemistry; D011758:Pyrroles / Q000737:chemistry; D013237:Stereoisomerism
D007211:Indoles; D009570:Nitriles; D011725:Pyridines; D011743:Pyrimidines; D011758:Pyrroles; D010165:Palladium