Cell distribution differences of matrix metalloproteinase-9 and tissue inhibitor of matrix metalloproteinase-1 in patients with Kawasaki disease.
The interaction of matrix metalloproteinase (MMP)-9 and tissue inhibitor of matrix metalloproteinase-1 has been implicated in the formation of coronary aneurysms in Kawasaki disease. MMP-9 and tissue inhibitor of matrix metalloproteinase-1 were distributed predominantly in the granulocytes and platelets, respectively, in patients with Kawasaki disease. The plasma values of MMP-9 correlated positively with the circulating neutrophil count. Inhibiting the activity of granulocytes and maintaining the platelet activity might prevent coronary aneurysms.
Department of Pediatrics and Child Neurology, Oita University Faculty of Medicine, Hasama, Yufu, Oita, Japan. kseigo@oita-u.ac.jp
Seigo
S
Korematsu
Yoko
Y
Ohta
Naotaka
N
Tamai
Masahiro
M
Takeguchi
Chika
C
Goto
Hiroaki
H
Miyahara
Tatsuya
T
Kawano
Tatsuro
T
Izumi
D001792:Blood Platelets / Q000201:enzymology; D001798:Blood Proteins / Q000737:chemistry; D016022:Case-Control Studies; D002675:Child, Preschool; D003323:Coronary Aneurysm / Q000201:enzymology; D005260:Female; D006801:Humans; D016756:Immunoglobulins, Intravenous / Q000627:therapeutic use; D007223:Infant; D007958:Leukocyte Count; D007962:Leukocytes / Q000201:enzymology; D008297:Male; D020780:Matrix Metalloproteinase 9 / Q000097:blood*; D009080:Mucocutaneous Lymph Node Syndrome / Q000188:drug therapy / Q000201:enzymology*; D019715:Tissue Inhibitor of Metalloproteinase-1 / Q000097:blood*
D001798:Blood Proteins; D016756:Immunoglobulins, Intravenous; D019715:Tissue Inhibitor of Metalloproteinase-1; D020780:Matrix Metalloproteinase 9