Effects of different growth factors and carriers on bone regeneration: a systematic review.
OBJECTIVE
The application and subsequent investigations in the use of varied osteogenic growth factors in bone regeneration procedures have grown dramatically over the past several years. Owing to this rapid gain in popularity and documentation, a review was undertaken to evaluate the in vivo effects of growth factors on bone regeneration.


METHODS
Using related key words, electronic databases (Medline, Embase, and Cochrane) were searched for articles published from 1999 to April 2010 to find growth factor application in bone regeneration in human or animal models.


RESULTS
A total of 63 articles were matched with the inclusion criteria of this study. Bone morphogenetic protein 2 (BMP-2) was the most studied growth factor. Carriers for the delivery, experimental sites, and methods of evaluation were different, and therefore articles did not come to a general agreement.


CONCLUSIONS
Within the limitations of this review, BMP-2 may be an appropriate growth factor for osteogenesis.
Assistant Professor of Oral and Maxillofacial Surgery, Department of Oral and Maxillofacial Surgery, Shahid Beheshti University of Medical Sciences, Tehran, Iran; Head, Division of Basic Sciences, Dental Research Center, Tehran, Iran. Electronic address: arashkhojasteh@yahoo.com.
Arash
A
Khojasteh
Hossein
H
Behnia
Navid
N
Naghdi
Mohammad
M
Esmaeelinejad
Zahra
Z
Alikhassy
Mark
M
Stevens
D000818:Animals; D055396:Bone Morphogenetic Protein 2 / Q000494:pharmacology; D001861:Bone Regeneration / Q000187:drug effects*; D004337:Drug Carriers / Q000494:pharmacology; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins / Q000494:pharmacology*; D023421:Models, Animal; D010012:Osteogenesis / Q000187:drug effects*
D055396:Bone Morphogenetic Protein 2; D004337:Drug Carriers; D036341:Intercellular Signaling Peptides and Proteins