Transport through liquid membranes containing omeprazole and lansoprazole.
Omeprazole and lansoprazole, the therapeutically important drugs belonging to proton pump inhibitor category are extensively used in the treatment of gastric ulcers. Transport through liquid membranes generated by these drugs in lecithin-cholesterol mixture in series with a supporting membrane has been studied. The data obtained show the formation of liquid membrane in series with the supporting membrane. Transport of cations, chloride and bicarbonate ions in the presence liquid membranes generated by omeprazole and lanzoprazole indicate the modification in the permeability of various permeants.
Pharmacy Group, Birla Institute of Technology and Science, Pilani, Rajasthan 333 031. anantha@bits-pilani.ac.in
A N
AN
Nagappa
P V
PV
Pandi
P K
PK
Mishra
Rahul K
RK
Girish
I
I
Shanmukh
D053799:2-Pyridinylmethylsulfinylbenzimidazoles / Q000737:chemistry*; D001639:Bicarbonates / Q000737:chemistry; D001671:Biochemistry / Q000379:methods; D002412:Cations; D002626:Chemistry, Pharmaceutical / Q000379:methods; D002712:Chlorides / Q000737:chemistry; D002784:Cholesterol / Q000737:chemistry; D015195:Drug Design; D004791:Enzyme Inhibitors / Q000737:chemistry / Q000494:pharmacology; D006863:Hydrogen-Ion Concentration; D007477:Ions; D064747:Lansoprazole; D054709:Lecithins / Q000737:chemistry; D008567:Membranes, Artificial; D008954:Models, Biological; D008956:Models, Chemical; D008968:Molecular Conformation; D009853:Omeprazole / Q000737:chemistry*; D010539:Permeability
D053799:2-Pyridinylmethylsulfinylbenzimidazoles; D001639:Bicarbonates; D002412:Cations; D002712:Chlorides; D004791:Enzyme Inhibitors; D007477:Ions; D054709:Lecithins; D008567:Membranes, Artificial; D064747:Lansoprazole; D002784:Cholesterol; D009853:Omeprazole