[BRCA1: a new predictive genomic marker for chemotherapy and radiotherapy of non-small cell lung cancer].
Non-small cell lung cancer (NSCLC) is one of the most common malignant tumors worldwide. Chemotherapy and radiotherapy are the main methods in therapy of NSCLC. The identification and characterization of predictive markers of radio- and chemo-sensitivity will be beneficial with customized treatment of NSCLC patients. This article will review the evidence regarding breast cancer susceptibility gene 1 (BRCA1) as a new predictive marker for chemotherapy and radiotherapy of NSCLC.
School of Radiation Medicine and Protection, Medical College of Soochow University, Suzhou 215123, China.
Min
M
Li
Saijun
S
Fan
D019313:BRCA1 Protein / Q000235:genetics*; D014408:Biomarkers, Tumor / Q000235:genetics*; D002289:Carcinoma, Non-Small-Cell Lung / Q000188:drug therapy / Q000235:genetics* / Q000473:pathology / Q000532:radiotherapy; D015894:Genome, Human / Q000235:genetics*; D006801:Humans; D008175:Lung Neoplasms / Q000188:drug therapy / Q000235:genetics* / Q000473:pathology / Q000532:radiotherapy; D011379:Prognosis
D019313:BRCA1 Protein; D014408:Biomarkers, Tumor