Compounds with antiproliferative activity on five human cancer cell lines from South Korean Carpesium triste.
In the search for antiproliferative compounds against human cancer cells (A549, SK-OV-3, SK-MEL-2, XF498, HCT15), it was found that the chloroform extracts obtained from the whole plant of Carpesium rosulatum Miq. (Compositae) exhibited significant cytotoxic activity. Two sesquiterpene lactones, CT-1 (2alpha,5-epoxy-5,10-dihydroxy-6-angeloyloxy-9beta-isobutyloxy-germacran-8alpha, 12-olide), and CT-2 (2beta,5-epoxy-5,10-dihydroxy-6alpha,9beta-diangeloyloxy-germacran-8alpha,12-olide) were isolated from the whole plant. CT-2 showed the most potent cytotoxicity with an IC50 value of 7.88 microM against SK-MEL-2.
Department of Medicinal Biotechnology, College of Natural Resources and Life Science, Dong-A University, Busan, South Korea. himun68@dau.ac.kr
Hyung-In
HI
Moon
D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry* / Q000494:pharmacology*; D019659:Asteraceae / Q000737:chemistry*; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D002851:Chromatography, High Pressure Liquid; D006801:Humans; D020128:Inhibitory Concentration 50; D015394:Molecular Structure; D056910:Republic of Korea
D000972:Antineoplastic Agents, Phytogenic