[Adamantane derivate enhances cerebral blood flow under conditions of ischemic brain damage].
Experiments have shown that adamantane derivate - 5-hydroxyadamantan-2-on (100 mg/kg, i.v.) enhances the local blood flow in the cerebral cortex of rats under global transient brain ischemia conditions, while not influencing the brain blood flow in intact rats. In the same dose, adamantane derivate significantly decreases mortality in rats under conditions of hypergravity ischemia. The cerebrovascular effect of adamantane derivate is abolished by bicuculline (GABA-A receptor blocker), which is evidence for a GABAergic component in the mechanism of the cerebrovascular action ofadamantane derivate.
R S
RS
Mirzoian
T S
TS
Gan'shina
D V
DV
Maslennikov
A I
AI
Turilova
N I
NI
Avdiunina
B M
BM
Piatin
D000218:Adamantane / Q000008:administration & dosage / Q000031:analogs & derivatives / Q000627:therapeutic use*; D000818:Animals; D000978:Antiparkinson Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D001640:Bicuculline / Q000008:administration & dosage; D001794:Blood Pressure / Q000187:drug effects; D002540:Cerebral Cortex / Q000098:blood supply / Q000187:drug effects* / Q000503:physiopathology; D002560:Cerebrovascular Circulation / Q000187:drug effects*; D058787:GABA-A Receptor Antagonists / Q000008:administration & dosage; D002546:Ischemic Attack, Transient / Q000188:drug therapy* / Q000401:mortality / Q000503:physiopathology; D017078:Laser-Doppler Flowmetry; D008297:Male; D051381:Rats; D011963:Receptors, GABA-A / Q000378:metabolism; D015996:Survival Rate
D000978:Antiparkinson Agents; D058787:GABA-A Receptor Antagonists; D011963:Receptors, GABA-A; D000218:Adamantane; D001640:Bicuculline