Decarboxylative acylation of cyclic enamides with α-oxocarboxylic acids by palladium-catalyzed C-H activation at room temperature.
An efficient catalytic decarboxylative acylation of unactivated sp(2) (alkenyl) C-H bonds has been developed. Various substituted α-oxocarboxylic acids with different electronic properties react under mild conditions to afford a diverse range of β-acyl enamide products in good yields. The reaction is proposed to proceed via a cyclic vinylpalladium intermediate, facilitating the decarboxylative dehydrogenative process with enamide coupling partners.
Department of Chemistry, School of Science and MOE Key Laboratory for Nonequilibrium Synthesis and Modulation of Condensed Matter, Xi'an Jiaotong University, Xi'an 710049, China.
Hua
H
Wang
Li-Na
LN
Guo
Xin-Hua
XH
Duan