Lipid apheresis techniques: current status in Germany.
For long-term lipid apheresis therapy, several different technical systems have been developed which enable effective reduction of LDL cholesterol and other atherogenic lipoproteins, such as Lp(a), with sufficient selectivity and good clinical tolerance. Suitable techniques include whole blood adsorption with polyacrylamide and dextran sulfate cellulose, while primary plasma separation is used for cascade filtration, heparin-induced precipitation, immunoadsorption, silicate gel adsorption, and dextran sulfate cellulose (both techniques). The technical features are described. Only intensive training and experience of the medical personnel guarantees reliable treatment safety of all systems at a very low rate of minor side effects.
Medizinische Klinik 2, Markus Krankenhaus, Frankfurt/Main, Germany. peter.gruetzmacher@fdk.info
Peter
P
Grützmacher
Claudius
C
Kleinert
D000180:Acrylic Resins / Q000737:chemistry; D000327:Adsorption; D001781:Blood Component Removal / Q000009:adverse effects / Q000379:methods*; D002482:Cellulose / Q000737:chemistry; D011232:Chemical Precipitation; D008078:Cholesterol, LDL / Q000097:blood*; D016264:Dextran Sulfate / Q000737:chemistry; D005858:Germany; D006493:Heparin / Q000737:chemistry; D006801:Humans; D006937:Hypercholesterolemia / Q000503:physiopathology / Q000628:therapy*; D017270:Lipoprotein(a) / Q000097:blood*; D000099166:Polyacrylamides
D000180:Acrylic Resins; D002482:Cellulose; D008078:Cholesterol, LDL; D016264:Dextran Sulfate; D006493:Heparin; D017270:Lipoprotein(a); D000099166:Polyacrylamides