SEN virus detection in thalassemic patients infected with hepatitis C virus.
HCV infection is known to be associated with clinical complications in thalassemic patients. D and H genotypes of SEN virus (SENV) are associated with blood-product transfusion and possibly non-A-to-E hepatitis. In this study, SENV viremia and its effect on liver ALT level in thalassemic patients, thalassemic patients infected with HCV, and HCV-infected patients were examined. Semi-nested PCR was conducted for detection of genotype H and D DNA, and the level of alanine aminotransferase (ALT) was measured. There was no significant difference in the mean ALT level in the studied groups and between SENV-positive and SENV-negative individuals. The results also showed that SENV infection does not affect the ALT level in these patients.
Blood Transfusion Research Center, High Institute for Research and Education in Transfusion Medicine, Blood Transfusion Organization, 146651157 Tehran, Iran.
Hadi Omidi
HO
Sani
Zohreh
Z
Sharifi
Seyed Masoud
SM
Hosseini
Mahmood Mahmoodian
MM
Shooshtari
D000293:Adolescent; D000328:Adult; D004266:DNA Virus Infections / Q000175:diagnosis* / Q000821:virology*; D005260:Female; D016174:Hepacivirus / Q000302:isolation & purification*; D006526:Hepatitis C / Q000150:complications*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010802:Phylogeny; D013789:Thalassemia / Q000150:complications*; D022783:Torque teno virus / Q000145:classification / Q000235:genetics / Q000302:isolation & purification*; D014766:Viremia; D055815:Young Adult