Science to practice: can macrophage infiltration serve as a surrogate marker for stem cell viability?
Following in vivo prelabeling of host macrophages with ultrasmall superparamagnetic iron oxide (USPIO) nanoparticles, it was shown that their magnetic resonance (MR) imaging–visible migration into knee implants of scaffolded adipose-derived stem cells (ADSCs) undergoing apoptosis can serve as a surrogate marker of stem cell death.
Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine 720 Rutland Ave, 217 Traylor, Baltimore, MD 21205, USA. jwmbulte@mri.jhu.edu
Jeff W M
JW
Bulte
D000273:Adipose Tissue / Q000166:cytology; D000818:Animals; D017209:Apoptosis; D015415:Biomarkers; D002470:Cell Survival; D003287:Contrast Media / Q000378:metabolism; D003911:Dextrans / Q000378:metabolism*; D006801:Humans; D007718:Knee Injuries / Q000628:therapy; D008262:Macrophage Activation; D008264:Macrophages / Q000378:metabolism*; D008279:Magnetic Resonance Imaging; D058185:Magnetite Nanoparticles; D053758:Nanoparticles; D033581:Stem Cell Transplantation; D023822:Tissue Engineering / Q000379:methods; D054457:Tissue Scaffolds
D015415:Biomarkers; D003287:Contrast Media; D003911:Dextrans; D058185:Magnetite Nanoparticles; C065507:ferumoxides