Catalase and lipid peroxidation values in serum of Tunisian patients with pemphigus vulgaris and foliaceus.
Pemphigus is an autoimmune disorder resulting from the interaction between autoantibodies and desmoglein. Oxidative stress seems to be responsible for the onset/aggravation of many human diseases. Actually, it is considered as one of the several factors for the etiopathogenesis of pemphigus. The present study aims to evaluate the oxidative state in the sera of pemphigus vulgaris and pemphigus foliaceus patients by assessing lipid peroxidation, proteins oxidation, and antioxidant enzyme activity. This study included 36 pemphigus vulgaris and 42 pemphigus foliaceus patients as well as a group of controls consisting of 78 healthy volunteers. Malondialdehyde levels (p < 0.001) and catalase activity (p < 0.001) are higher in both groups of patients than in the control group. The two groups of patients showed a nonsignificant decrease in the thiol groups compared with the healthy one. A nonsignificant difference was shown between pemphigus vulgaris and pemphigus foliaceus patients, except for the catalase which shows an increase in the pemphigus vulgaris group. We have also found significant correlations between serum oxidative stress marker levels and serum anti-desmoglein antibody levels in the two pemphigus groups. These findings underline the implication of oxidative stress in the physiopathology of pemphigus by the increase in the autoantibodies' reactivity.
Unité de recherche d' auto-immunité et immunogénétique, hôpital Habib Bourguiba, Sfax, Tunisia. olfaabida@yahoo.fr
Olfa
O
Abida
Riadh
R
Ben Mansour
Bochra
B
Gargouri
Mourad
M
Ben Ayed
Abderrahmen
A
Masmoudi
Hamida
H
Turki
Hatem
H
Masmoudi
Saloua
S
Lassoued
D000328:Adult; D001323:Autoantibodies / Q000032:analysis; D015415:Biomarkers / Q000097:blood; D001798:Blood Proteins / Q000032:analysis / Q000737:chemistry; D016022:Case-Control Studies; D002374:Catalase / Q000097:blood*; D051182:Desmogleins / Q000037:antagonists & inhibitors; D005260:Female; D006801:Humans; D015227:Lipid Peroxidation; D008297:Male; D008315:Malondialdehyde / Q000097:blood; D008875:Middle Aged; D010084:Oxidation-Reduction; D018384:Oxidative Stress; D010392:Pemphigus / Q000097:blood* / Q000209:etiology / Q000276:immunology; D017382:Reactive Oxygen Species / Q000097:blood; D013438:Sulfhydryl Compounds / Q000097:blood; D014416:Tunisia
D001323:Autoantibodies; D015415:Biomarkers; D001798:Blood Proteins; D051182:Desmogleins; D017382:Reactive Oxygen Species; D013438:Sulfhydryl Compounds; D008315:Malondialdehyde; C577219:CAT protein, human; D002374:Catalase