Role changes of β-catenin in kidney injury and repair.
Using conditional knockout models, Zhou et al. firmly establish a renoprotective role of β-catenin in acute kidney injury. Although β-catenin is protective at the injury phase, whether it helps kidney repair remains in question. In a renal cell scratch model, β-catenin suppresses wound healing. Moreover, continuous activation of β-catenin may lead to renal fibrosis. Further investigation should elucidate the distinct roles played by β-catenin and related signaling in kidney injury, repair, and fibrosis.
Jianping
J
Peng
Zheng
Z
Dong
D000818:Animals; D058534:Class I Phosphatidylinositol 3-Kinases / Q000378:metabolism*; D004317:Doxorubicin; D005923:Glomerulosclerosis, Focal Segmental / Q000201:enzymology*; D007668:Kidney / Q000201:enzymology*; D008297:Male; D011507:Proteinuria / Q000201:enzymology*; D015398:Signal Transduction; D051900:Smad3 Protein / Q000378:metabolism*
D051900:Smad3 Protein; C497791:Smad3 protein, mouse; D004317:Doxorubicin; C509622:1-phosphatidylinositol 3-kinase p110 subunit, mouse; D058534:Class I Phosphatidylinositol 3-Kinases