Theranostic probe based on lanthanide-doped nanoparticles for simultaneous in vivo dual-modal imaging and photodynamic therapy.
Dual-modal in vivo tumor imaging and photodynamic therapy using hexagonal NaYF(4):Yb,Er/NaGdF(4) core-shell upconverting nanoparticles combined with a photosensitizer, chlorin e6, is reported. Tumors can be clearly observed not only in the upconversion luminescence image but also in the magnetic resonance image. In vivo photodynamic therapy by systemic administration is demonstrated under 980 nm irradiation.
World Class University Program of Chemical Convergence for Energy & Environment, Institute of Chemical Processes, School of Chemical and Biological Engineering, Seoul National University, South Korea.
Yong Il
YI
Park
Hyung Min
HM
Kim
Jeong Hyun
JH
Kim
Kyung Chul
KC
Moon
Byeongjun
B
Yoo
Kang Taek
KT
Lee
Nohyun
N
Lee
Yoonseok
Y
Choi
Wooram
W
Park
Daishun
D
Ling
Kun
K
Na
Woo Kyung
WK
Moon
Seung Hong
SH
Choi
Hong Seok
HS
Park
Soo-Young
SY
Yoon
Yung Doug
YD
Suh
Sung Ho
SH
Lee
Taeghwan
T
Hyeon
D000818:Animals; D045744:Cell Line, Tumor; D002735:Chlorophyllides; D006801:Humans; D007259:Infrared Rays; D028581:Lanthanoid Series Elements / Q000737:chemistry*; D008163:Luminescent Measurements; D008279:Magnetic Resonance Imaging; D053768:Metal Nanoparticles / Q000737:chemistry* / Q000627:therapeutic use; D051379:Mice; D008807:Mice, Inbred BALB C; D008819:Mice, Nude; D009369:Neoplasms / Q000175:diagnosis / Q000188:drug therapy; D010778:Photochemotherapy; D017319:Photosensitizing Agents / Q000737:chemistry / Q000627:therapeutic use; D011166:Porphyrins / Q000737:chemistry / Q000627:therapeutic use; D014183:Transplantation, Heterologous
D002735:Chlorophyllides; D028581:Lanthanoid Series Elements; D017319:Photosensitizing Agents; D011166:Porphyrins; C062985:phytochlorin