[Effects of new amino acid derivates of dopamine on anxiety-like behavior].
This study was aimed at a comparative analysis of the effects of new amino acid derivatives of dopamine (IEM-2111, IEM-21122, IEM-2123, IEM-2126) on anxiety-like behavior in rats. The behavioral effects of the dopamine-like substances were evaluated under conditions of acute and chronic experiments. In acute experiment, a single dose of substances was administered 45 min prior to the behavioral testing of animals. In chronic experiment, the synthesized compounds were administered in a single daily dose for 14 days. Pharmacological analysis of the effect of drugs was performed in the following doses: 0.1, 1.0, and 10.0 mg/kg (i.p., introduction). Diazepam was used as a reference drug that was introduced in a dose of 1.0 mg/kg (i.p.). The anxiety-like state was determined using the elevated plus maze test, while the behavioral effects were evaluated in the open field test. It was found that IEM-2111, IEM-2122, and IEM-2123 exhibited anxiolytic action under condition of chronic administration, whereas IEM-2126 produced an anxiolytic effect only after acute administration. The introduction of left optical isomers of aromatic or heterocyclic radicals of amino acids into the molecule of 3,4-dimetoxyphenylethylamine results in a more pronounced anxiolytic effect upot chronic administration. The degree of action of the new amino acid derivatives of dopamine has a dose-dependent character, and the maximum effect is manifested at a dose of 1.0 mg/kg.
Iu O
IuO
Fedotova
V V
VV
Barishpolets
N S
NS
Sapronov
D000596:Amino Acids / Q000737:chemistry*; D000818:Animals; D014151:Anti-Anxiety Agents / Q000008:administration & dosage*; D001007:Anxiety / Q000188:drug therapy* / Q000503:physiopathology; D001362:Avoidance Learning / Q000187:drug effects; D001522:Behavior, Animal / Q000187:drug effects; D003975:Diazepam / Q000008:administration & dosage; D004298:Dopamine / Q000008:administration & dosage / Q000031:analogs & derivatives; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D004644:Emotions / Q000187:drug effects; D008297:Male; D018782:Maze Learning / Q000187:drug effects; D009043:Motor Activity / Q000187:drug effects; D051381:Rats; D017208:Rats, Wistar; D013237:Stereoisomerism
D000596:Amino Acids; D014151:Anti-Anxiety Agents; D003975:Diazepam; D004298:Dopamine