Nutrition support and infections associated with hepatic resection and liver transplantation in patients with chronic liver disease.
Malnutrition is common in liver cirrhotic patients who will undergo liver resection or liver transplantation. A precise evaluation of their nutrition status is thus difficult because of the presence of ascites and the edema caused by their impaired protein synthesis. Both perioperative enteral and parenteral nutrition have benefits in reducing the morbidity and mortality of liver surgery, and in general, oral nutrition supplements are recommended. Branched-chain amino acids (BCAAs) promote protein and glycogen synthesis and regulate immune system function. Synbiotics, a combination of pro- and prebiotics, is reported to enhance immune responses. Oral nutrition support with BCAAs, synbiotics, and an immune-enhancing diet have a beneficial effect on preventing the perioperative infections associated with hepatic resection or liver transplantation.
Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
Toshiro
T
Masuda
Ken
K
Shirabe
Shohei
S
Yoshiya
Rumi
R
Matono
Kazutoyo
K
Morita
Naotaka
N
Hashimoto
Toru
T
Ikegami
Tomoharu
T
Yoshizumi
Hideo
H
Baba
Yoshihiko
Y
Maehara
D000597:Amino Acids, Branched-Chain / Q000008:administration & dosage*; D016470:Bacteremia / Q000150:complications / Q000382:microbiology / Q000517:prevention & control; D019587:Dietary Supplements; D006498:Hepatectomy; D006801:Humans; D008099:Liver / Q000473:pathology / Q000601:surgery; D008107:Liver Diseases / Q000150:complications / Q000503:physiopathology / Q000601:surgery*; D016031:Liver Transplantation; D044342:Malnutrition / Q000150:complications / Q000178:diet therapy / Q000503:physiopathology*; D009752:Nutritional Status; D018529:Nutritional Support / Q000379:methods*; D011183:Postoperative Complications / Q000382:microbiology / Q000517:prevention & control / Q000601:surgery; D056692:Prebiotics; D019936:Probiotics / Q000008:administration & dosage; D058616:Synbiotics
D000597:Amino Acids, Branched-Chain; D056692:Prebiotics