LKB1 and AMP-activated protein kinase: regulators of cell polarity.
Adenosine monophosphate-activated protein kinase (AMPK), a metabolic protein kinase, and its upstream kinase LKB1 play crucial roles in the establishment and maintenance of cell polarity. Although the shapes of polarized cells display extraordinary diversity, the key molecules involved in cell polarity are relatively well conserved. Here, we review the mechanisms and factors responsible for organizing cell polarity and the role of LKB1 and AMPK in cell polarity.
Department of Molecular Cardiology, Osaka University Graduate School of Medicine, Suita, Osaka, 565-0871, Japan. nakano-atu@nyc.odn.ne.jp
Atsushi
A
Nakano
Seiji
S
Takashima
D000091162:AMP-Activated Protein Kinase Kinases; D055372:AMP-Activated Protein Kinases / Q000235:genetics / Q000502:physiology*; D000818:Animals; D017173:Caenorhabditis elegans / Q000201:enzymology / Q000502:physiology; D002465:Cell Movement; D016764:Cell Polarity; D048430:Cell Shape; D004330:Drosophila / Q000201:enzymology / Q000235:genetics / Q000502:physiology; D029721:Drosophila Proteins / Q000235:genetics / Q000502:physiology*; D015971:Gene Expression Regulation, Enzymologic; D008322:Mammals / Q000235:genetics / Q000502:physiology; D008869:Microtubule-Associated Proteins / Q000235:genetics / Q000502:physiology; D008870:Microtubules / Q000502:physiology; D009363:Neoplasm Proteins / Q000235:genetics / Q000502:physiology; D010766:Phosphorylation; D011494:Protein Kinases / Q000235:genetics / Q000502:physiology*
D029721:Drosophila Proteins; D008869:Microtubule-Associated Proteins; D009363:Neoplasm Proteins; C076744:cytoplasmic linker protein 170; D011494:Protein Kinases; C495775:LKB1 protein, Drosophila; D000091162:AMP-Activated Protein Kinase Kinases; D055372:AMP-Activated Protein Kinases