Tissue engineering for the meniscus: a review of the literature.
The menisci disperse the load at the knee joint. Removal of the menisci can lead to osteoarthritis due to the higher load placed on the underlying cartilage. If they become injured it is therefore important to replace or regenerate the meniscus to prevent the progression of osteoarthritis. Many materials have been trialled to find a scaffold that can withstand the stresses and strains across the joint without causing any adverse effects. This review looks at these materials further to clarify the current position of tissue engineering for the meniscus and to highlight the areas where further research is needed. A scaffold which can produce high quality in vivo results in everyone has not yet been found.
University College London Institute of Orthopaedics and Musculoskeletal Sciences, Royal National Orthopaedic Hospital, Stanmore, Middlesex, HA7 4LP, UK.
Bethan
B
Tucker
Wasim
W
Khan
Mamun
M
Al-Rashid
Hesham
H
Al-Khateeb