A study of a biodegradable Mg-3Sc-3Y alloy and the effect of self-passivation on the in vitro degradation.
Magnesium and its alloys have been investigated for their potential application as biodegradable implant materials. Although properties of magnesium such as biocompatibility and susceptibility to dissolution are desirable for biodegradable implant applications, its high degradation rate and low strength pose a significant challenge. A potential way to reduce the initial degradation rate is to form a self-passivating protective layer on the surface of the alloy. Oxides with a low enthalpy of formation result in a strong thermodynamic driving force to produce oxide surfaces that are more stable than the native oxide (MgO), and possibly reduce the initial degradation rate in these alloys. In the present study a ternary Mg-3wt.% Sc-3wt.% Y alloy was investigated and its oxidation behavior studied. The effect of surface passivation on the in vitro degradation rate was studied and the degradation products identified. The results show that the oxide provided an initial degradation barrier and 24h oxidation resulted in a negligible degradation rate for up to 23 days. Furthermore, the degradation products of the alloy showed no significant toxicity to osteoblastic cells, and cell proliferation studies confirmed cell attachment and proliferation on the surface of the oxidized alloy.
Department of Materials Science and Engineering, University of Florida, Gainesville, FL 32611, USA.
Harpreet S
HS
Brar
Jordan P
JP
Ball
Ida S
IS
Berglund
Josephine B
JB
Allen
Michele V
MV
Manuel
D020341:Absorbable Implants; D000497:Alloys / Q000494:pharmacology*; D000818:Animals; D016923:Cell Death / Q000187:drug effects; D048430:Cell Shape / Q000187:drug effects; D051379:Mice; D008855:Microscopy, Electron, Scanning; D010006:Osteoblasts / Q000166:cytology / Q000187:drug effects / Q000648:ultrastructure; D010084:Oxidation-Reduction / Q000187:drug effects; D056951:Photoelectron Spectroscopy; D013816:Thermodynamics; D013997:Time Factors; D014961:X-Ray Diffraction
D000497:Alloys; C581571:Mg-3Sc-3Y alloy