Asymmetric syntheses of (-)-pentazocine and (-)-eptazocine through an aza-Prins cyclization.
Two down more to go: The asymmetric syntheses of (-)-pentazocine and (-)-eptazocine are presented. The highlights of the syntheses are the construction of the core skeleton through an aza-Prins cyclization and intramolecular Friedel-Crafts reaction.
State Key Laboratory of Applied Organic Chemistry, Department of Chemistry, Lanzhou University, Lanzhou 730000, PR China.
Qiang
Q
Chen
Xing
X
Huo
Zhen
Z
Yang
Xuegong
X
She
D001372:Aza Compounds / Q000737:chemistry*; D018360:Crystallography, X-Ray; D003496:Cyclazocine / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry; D003500:Cyclization; D008968:Molecular Conformation; D010423:Pentazocine / Q000138:chemical synthesis* / Q000737:chemistry; D013237:Stereoisomerism
D001372:Aza Compounds; C033776:eptazocine; D003496:Cyclazocine; D010423:Pentazocine