Quantitative biology of single neurons.
The building blocks of complex biological systems are single cells. Fundamental insights gained from single-cell analysis promise to provide the framework for understanding normal biological systems development as well as the limits on systems/cellular ability to respond to disease. The interplay of cells to create functional systems is not well understood. Until recently, the study of single cells has concentrated primarily on morphological and physiological characterization. With the application of new highly sensitive molecular and genomic technologies, the quantitative biochemistry of single cells is now accessible.
Department of Pharmacology, Perelman School of Medicine, University of Pennsylvania, 36th and Hamilton Walk, Philadelphia, PA 19104, USA. eberwine@upenn.edu
James
J
Eberwine
Ditte
D
Lovatt
Peter
P
Buckley
Hannah
H
Dueck
Chantal
C
Francis
Tae Kyung
TK
Kim
Jaehee
J
Lee
Miler
M
Lee
Kevin
K
Miyashiro
Jacqueline
J
Morris
Tiina
T
Peritz
Terri
T
Schochet
Jennifer
J
Spaethling
Jai-Yoon
JY
Sul
Junhyong
J
Kim
D004594:Electrophysiology; D005786:Gene Expression Regulation; D017403:In Situ Hybridization; D007473:Ion Channels / Q000502:physiology; D009474:Neurons / Q000166:cytology / Q000502:physiology*; D014176:Protein Biosynthesis; D040901:Proteomics / Q000379:methods; D059010:Single-Cell Analysis / Q000379:methods*; D013269:Stochastic Processes; D059467:Transcriptome
D007473:Ion Channels