Mast cell proteoglycans.
Mast cells are versatile effector cells of the immune system, contributing to both innate and adaptive immunity toward pathogens but also having profound detrimental activities in the context of inflammatory disease. A hallmark morphological feature of mast cells is their large content of cytoplasmic secretory granules, filled with numerous secretory compounds, including highly negatively charged heparin or chondroitin sulfate proteoglycans of serglycin type. These anionic proteoglycans provide the basis for the strong metachromatic staining properties of mast cells seen when applying various cationic dyes. Functionally, the mast cell proteoglycans have been shown to have an essential role in promoting the storage of other granule-contained compounds, including bioactive monoamines and different mast cell-specific proteases. Moreover, granule proteoglycans have been shown to regulate the enzymatic activities of mast cell proteases and to promote apoptosis. Here, the current knowledge of mast cell proteoglycans is reviewed.
Swedish University of Agricultural Sciences, Department of Anatomy, Physiology and Biochemistry, Uppsala, Sweden.
Elin
E
Rönnberg
Fabio R
FR
Melo
Gunnar
G
Pejler
D000818:Animals; D017209:Apoptosis; D011508:Chondroitin Sulfate Proteoglycans / Q000378:metabolism; D006025:Glycosaminoglycans / Q000378:metabolism; D006493:Heparin / Q000031:analogs & derivatives / Q000378:metabolism; D006801:Humans; D008407:Mast Cells / Q000378:metabolism*; D010447:Peptide Hydrolases / Q000378:metabolism; D011509:Proteoglycans / Q000378:metabolism*; D022142:Secretory Vesicles / Q000378:metabolism; D015238:Sulfotransferases / Q000378:metabolism; D033921:Vesicular Transport Proteins / Q000378:metabolism
D011508:Chondroitin Sulfate Proteoglycans; D006025:Glycosaminoglycans; D011509:Proteoglycans; D033921:Vesicular Transport Proteins; C036090:heparin proteoglycan; C075430:serglycin; D006493:Heparin; D015238:Sulfotransferases; D010447:Peptide Hydrolases