[Molecular signaling pathways. Mechanisms and clinical use].
This brief summary on the role of experimental radiation oncology highlights several new research topics and research approaches that offer great potential for the optimization of modern radiation oncology. In addition, many areas of research, such as hypoxia, angiogenesis, the immune system, and metabolism, to name a few, comprise a substantial part of our current knowledge of tumor and radiation biology. Which new insights and therapeutic possibilities via the Human Cancer Genome Project or new processes, such as next generation sequencing may offer, cannot be easily foreseen at present. However, we do know for certain: radiation biology has and will continue to contribute to improvements in radiation oncology.
OncoRay - Nationales Zentrum für Strahlenforschung in der Onkologie, Universitätsklinik und Medizinische Fakultät Carl Gustav Carus, Technische Universität Dresden, Fetscherstr. 74 / PF 41, 01307 Dresden. Nils.Cordes@OncoRay.de
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D000818:Animals; D017209:Apoptosis / Q000528:radiation effects; D049109:Cell Proliferation; D002470:Cell Survival / Q000528:radiation effects; D004249:DNA Damage / Q000235:genetics / Q000528:radiation effects; D004260:DNA Repair / Q000235:genetics / Q000528:radiation effects; D066246:ErbB Receptors / Q000235:genetics / Q000502:physiology; D005109:Extracellular Matrix / Q000528:radiation effects; D015972:Gene Expression Regulation, Neoplastic / Q000235:genetics / Q000528:radiation effects; D006801:Humans; D051034:Inhibitor of Apoptosis Proteins / Q000502:physiology; D016023:Integrins / Q000502:physiology; D009369:Neoplasms / Q000235:genetics* / Q000532:radiotherapy*; D011836:Radiation Tolerance / Q000235:genetics / Q000528:radiation effects; D015398:Signal Transduction / Q000528:radiation effects*; D000077022:Survivin; D014407:Tumor Cells, Cultured / Q000528:radiation effects
C107489:BIRC5 protein, human; D051034:Inhibitor of Apoptosis Proteins; D016023:Integrins; D000077022:Survivin; C512478:EGFR protein, human; D066246:ErbB Receptors