Therapeutic effects of selective atrioventricular node vagal stimulation in atrial fibrillation and heart failure.
BACKGROUND
Atrial fibrillation (AF) and heart failure (HF) frequently coexist. We have previously demonstrated that selective atrioventricular node (AVN) vagal stimulation (AVN-VS) can be used to control ventricular rate during AF. Due to withdrawal of vagal activity in HF, the therapeutic effects of AVN-VS may be compromised in the combined condition of AF and HF. Accordingly, this study was designed to evaluate the therapeutic effects of AVN-VS to control ventricular rate in AF and HF.


RESULTS
A combined model of AF and HF was created by implanting a dual chamber pacemaker in 24 dogs. A newly designed bipolar electrode was inserted into the ganglionic AVN fat pad and connected to a nerve stimulator for delivering AVN-VS. In all dogs, HF was induced by high rate ventricular pacing at 220 bpm for 4 weeks. AF was then induced and maintained by rapid atrial pacing at 600 bpm after discontinuation of ventricular pacing. These HF + AF dogs were randomized into control (n = 9) and AVN-VS (n = 15) groups. In the latter group, vagal stimulation (310 μs, 20 Hz, 3-7 mA) was delivered continuously for 6 months. Compared with the control, AVN-VS had a consistent effect on ventricular rate slowing (by >50 bpm, all P < 0.001) during the entire 6-month observation period that was associated with left ventricular functional improvement. Moreover, AVN-VS was well tolerated by the treated animals.


CONCLUSIONS
AVN-VS achieved consistent rate slowing, which was associated with improved ventricular function in a canine AF and HF model. Thus, AVN-VS may be a novel, effective therapeutic option in the combined condition of AF and HF.
Department of Molecular Cardiology, The Cleveland Clinic, Cleveland, Ohio, USA. yzhang49@nyit.edu
Youhua
Y
Zhang
Zoran B
ZB
Popović
Kenya
K
Kusunose
Todor N
TN
Mazgalev
D000818:Animals; D001281:Atrial Fibrillation / Q000150:complications / Q000503:physiopathology* / Q000628:therapy*; D001283:Atrioventricular Node / Q000503:physiopathology*; D004285:Dogs; D006333:Heart Failure / Q000150:complications / Q000503:physiopathology* / Q000628:therapy*; D010138:Pacemaker, Artificial; D016896:Treatment Outcome; D055536:Vagus Nerve Stimulation / Q000379:methods*