Early experience with (68)Ga-DOTATATE preparation.
Neuroendocrine tumors (NETs) are a rare form of cancer. NETs frequently express cell membrane-specific peptide receptors, such as somatostatin receptors (SSTRs). Radiolabeled peptides bind to SSTR and provide in vivo histopathological information for diagnostic purposes. (68)Ga-DOTATATE has higher sensitivity for low-grade tumors and greater avidity to well-differentiated NETs than (18)F-FDG, being superior to (111)In-DTPA-octreotide and (18)F-DOPA in evaluation of well-differentiated metastatic NETs. The feasibility of (68)Ga-DOTATATE application in routine clinical practice for PET imaging of NETs was determined in a limited number of known cases (n = 6). (68)Ga-DOTATATE scan could detect all known sites of NETs and in one case previously unknown peritoneal metastasis. Early regulatory consideration is important for routine clinical use.
Clinical Imaging Research Centre, National University of Singapore, Singapore. medmms@nus.edu.sg
Maung Maung
MM
Saw
D005710:Gallium Radioisotopes / Q000302:isolation & purification*; D006801:Humans; D007553:Isotope Labeling; D049268:Positron-Emission Tomography; D011876:Radionuclide Generators; D019275:Radiopharmaceuticals / Q000138:chemical synthesis*
D005710:Gallium Radioisotopes; D019275:Radiopharmaceuticals