Reduced T helper and B lymphocytes in Parkinson's disease.
Gene association with HLA suggests involvement of immune mediated mechanisms in the pathogenesis of Parkinson's disease (PD). Only a small number of studies have found differences between circulating leukocyte populations in PD patients compared to controls, with conflicting results. To clarify whether there is a circulating leukocyte PD phenotype, we assessed the numbers of T, B and natural killer cells, and monocytes and found a small reduction (15-25%) in CD4+ T and CD19+ B cells in PD. These findings suggest some compromise in immune cells in PD and have potential implications for immune function and the progression of PD.
School of Medical Sciences, The University of New South Wales, and Neuroscience Research Australia, Sydney, Australia.
Claire H
CH
Stevens
Dominic
D
Rowe
Marie-Christine
MC
Morel-Kopp
Carolyn
C
Orr
Tonia
T
Russell
Madelaine
M
Ranola
Christopher
C
Ward
Glenda M
GM
Halliday
D000368:Aged; D001402:B-Lymphocytes / Q000276:immunology*; D005260:Female; D005434:Flow Cytometry; D006801:Humans; D008297:Male; D010300:Parkinson Disease / Q000097:blood / Q000276:immunology*; D006377:T-Lymphocytes, Helper-Inducer / Q000276:immunology*