mRNA localization: an orchestration of assembly, traffic and synthesis.
Asymmetrical mRNA localization and subsequent local translation provide efficient mechanisms for protein sorting in polarized cells. Defects in mRNA localization have been linked to developmental abnormalities and neurological diseases. Thus, it is critical to understand the machineries mediating and mechanisms underlying the asymmetrical distribution of mRNA and its regulation. The goal of this review is to summarize recent advances in the understanding of mRNA transport and localization, including the assembly and sorting of transport messenger ribonucleic protein (mRNP) granules, molecular mechanisms of active mRNP transport, cytoskeletal interactions and regulation of these events by extracellular signals.
Department of Cell Biology, Emory University School of Medicine, Atlanta, GA 30322, USA.
Lei
L
Xing
Gary J
GJ
Bassell
D000818:Animals; D006801:Humans; D020409:Molecular Motor Proteins / Q000378:metabolism; D034443:RNA Transport; D012333:RNA, Messenger / Q000378:metabolism*; D012261:Ribonucleoproteins / Q000378:metabolism; D015398:Signal Transduction
D020409:Molecular Motor Proteins; D012333:RNA, Messenger; D012261:Ribonucleoproteins