Investigation into the role of five Salmonella enterica serovar Enteritidis genomic islands in colonization of the chicken reproductive tract and other organs following oral challenge.
Salmonella enterica serovar Enteritidis is a major cause of human gastrointestinal tract disease, infection being due in large part to the consumption of contaminated eggs. Recent genome sequencing of S. enterica serovars has identified genomic islands, the presence of which differs between serovars. Using defined mutants, we have investigated the contribution that five such loci play in the colonization of the avian reproductive tract, other organs and avian macrophages. All loci appear to play a small role in infection of liver and spleen, but not in colonization of the reproductive tract or macrophages.
Department of Veterinary Medicine, University of Cambridge, Cambridge, UK. cc122@cam.ac.uk
Chris
C
Coward
Leanne
L
Sait
Lisa
L
Williams
Tom J
TJ
Humphrey
Tristan
T
Cogan
Duncan J
DJ
Maskell
D000825:Animal Structures / Q000382:microbiology; D000818:Animals; D001426:Bacterial Proteins / Q000235:genetics / Q000378:metabolism; D002645:Chickens / Q000382:microbiology; D004195:Disease Models, Animal; D005260:Female; D044404:Genomic Islands; D006801:Humans; D010057:Oviducts / Q000382:microbiology; D012098:Reproduction; D012480:Salmonella Infections / Q000382:microbiology*; D012477:Salmonella enteritidis / Q000235:genetics / Q000254:growth & development / Q000502:physiology*
D001426:Bacterial Proteins