Programmed genome rearrangements: in lampreys, all cells are not equal.
How can organisms silence deleterious gene loci? A recent study has shed light on a very brute mechanism in a jawless vertebrate: the irreversible deletion of massive chunks of genomic DNA.
Institut de Génomique Fonctionnelle de Lyon (UMR 5242 du CNRS, Ecole Normale Supérieure de Lyon, Université Claude Bernard Lyon 1), Université de Lyon, 46 Allée d'Italie, 69364 Lyon Cedex 07, France.
Marie
M
Sémon
Michael
M
Schubert
Vincent
V
Laudet
D000818:Animals; D005260:Female; D017353:Gene Deletion; D015321:Gene Rearrangement; D016678:Genome; D005854:Germ Cells / Q000378:metabolism*; D007798:Lampreys / Q000235:genetics*; D008297:Male