Rationale for the clinical application of flow cytometry in patients with myelodysplastic syndromes: position paper of an International Consortium and the European LeukemiaNet Working Group.
An international working group within the European LeukemiaNet gathered, aiming to determine the role of flow cytometry (FC) in myelodysplastic syndromes (MDS). It was agreed that FC has a substantial application in disease characterization, diagnosis and prognosis. FC may also be useful in predicting treatment responses and monitoring novel and standard therapeutic regimens. In this article the rationale is discussed that flow cytometry should be integrated as a part of diagnostic and prognostic scoring systems in MDS.
Department of Hematology, VU University Medical Center, Amsterdam, The Netherlands. a.vandeloosdrecht@vumc.nl
Arjan A
AA
van de Loosdrecht
Robin
R
Ireland
Wolfgang
W
Kern
Matteo G
MG
Della Porta
Canan
C
Alhan
Jan Sebastian
JS
Balleisen
Peter
P
Bettelheim
David T
DT
Bowen
Kate
K
Burbury
Lisa
L
Eidenschink
Mario
M
Cazzola
Spencer S C
SS
Chu
Matthew
M
Cullen
Jevon A
JA
Cutler
Angelika M
AM
Dräger
Jean
J
Feuillard
Pierre
P
Fenaux
Patricia
P
Font
Ulrich
U
Germing
Detlef
D
Haase
Eva
E
Hellström-Lindberg
Ulrika
U
Johansson
Shahram
S
Kordasti
Michael R
MR
Loken
Luca
L
Malcovati
Jeroen G
JG
te Marvelde
Sergio
S
Matarraz
Timothy
T
Milne
Bijan
B
Moshaver
Ghulam J
GJ
Mufti
Veselka
V
Nikolova
Kiyoyuki
K
Ogata
Uta
U
Oelschlaegel
Alberto
A
Orfao
Gert J
GJ
Ossenkoppele
Anna
A
Porwit
Uwe
U
Platzbecker
Frank
F
Preijers
Katherina
K
Psarra
Stephen J
SJ
Richards
Dolores
D
Subirá
John F
JF
Seymour
Vicky
V
Tindell
Teresa
T
Vallespi
Peter
P
Valent
Vincent H J
VH
van der Velden
Denise A
DA
Wells
Theo M
TM
de Witte
Florian
F
Zettl
Marie C
MC
Béné
Theresia M
TM
Westers
D005434:Flow Cytometry / Q000379:methods*; D006801:Humans; D007390:International Agencies; D009190:Myelodysplastic Syndromes / Q000145:classification / Q000175:diagnosis* / Q000628:therapy*; D017063:Outcome Assessment, Health Care / Q000379:methods*; D011379:Prognosis; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D012958:Societies, Scientific