Internal catalase protects herpes simplex virus from inactivation by hydrogen peroxide.
Herpes simplex virus 1 (HSV-1) was shown to contain catalase, an enzyme able to detoxify hydrogen peroxide by converting it to water and oxygen. Studies with a catalase inhibitor indicated that virus-associated catalase can have a role in protecting the virus from oxidative inactivation. HSV-1 was found to be more sensitive to killing by hydrogen peroxide in the presence of a catalase inhibitor than in its absence. The results suggest a protective role for catalase during the time HSV-1 spends in the oxidizing environment outside a host cell.
Department of Microbiology, Immunology, and Cancer Biology, University of Virginia Health System, Charlottesville, Virginia, USA.
William W
WW
Newcomb
Jay C
JC
Brown
D000818:Animals; D002374:Catalase / Q000378:metabolism*; D002522:Chlorocebus aethiops; D004202:Disinfectants / Q000378:metabolism* / Q000633:toxicity*; D004791:Enzyme Inhibitors / Q000378:metabolism; D018259:Herpesvirus 1, Human / Q000187:drug effects*; D006861:Hydrogen Peroxide / Q000378:metabolism* / Q000633:toxicity*; D050296:Microbial Viability / Q000187:drug effects; D010100:Oxygen / Q000378:metabolism; D014709:Vero Cells; D019562:Viral Load; D014764:Viral Proteins / Q000378:metabolism*; D038301:Virus Inactivation / Q000187:drug effects; D014867:Water / Q000378:metabolism
D004202:Disinfectants; D004791:Enzyme Inhibitors; D014764:Viral Proteins; D014867:Water; D006861:Hydrogen Peroxide; D002374:Catalase; D010100:Oxygen