Vaccine-induced effector-memory CD8+ T cell responses predict therapeutic efficacy against tumors.
CD8(+) T cells have the potential to attack and eradicate cancer cells. The efficacy of therapeutic vaccines against cancer, however, lacks defined immune correlates of tumor eradication after (therapeutic) vaccination based on features of Ag-specific T cell responses. In this study, we examined CD8(+) T cell responses elicited by various peptide and TLR agonist-based vaccine formulations in nontumor settings and show that the formation of CD62L(-)KLRG1(+) effector-memory CD8(+) T cells producing the effector cytokines IFN-γ and TNF predicts the degree of therapeutic efficacy of these vaccines against established s.c. tumors. Thus, characteristics of vaccine-induced CD8(+) T cell responses instill a predictive determinant for the efficacy of vaccines during tumor therapy.
Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, 2333 ZA Leiden, The Netherlands.
Suzanne
S
van Duikeren
Marieke F
MF
Fransen
Anke
A
Redeker
Brigitte
B
Wieles
Gerard
G
Platenburg
Willem-Jan
WJ
Krebber
Ferry
F
Ossendorp
Cornelis J M
CJ
Melief
Ramon
R
Arens
D000595:Amino Acid Sequence; D000818:Animals; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology* / Q000821:virology; D019496:Cancer Vaccines / Q000008:administration & dosage / Q000276:immunology / Q000627:therapeutic use*; D005260:Female; D052162:Human papillomavirus 16 / Q000276:immunology*; D007156:Immunologic Memory; D007279:Injections, Subcutaneous; D051379:Mice; D020297:Mice, Congenic; D008810:Mice, Inbred C57BL; D008969:Molecular Sequence Data; D050725:Papillomavirus E7 Proteins / Q000008:administration & dosage* / Q000276:immunology* / Q000627:therapeutic use; D011237:Predictive Value of Tests; D014407:Tumor Cells, Cultured; D002583:Uterine Cervical Neoplasms / Q000276:immunology / Q000517:prevention & control* / Q000821:virology; D014765:Viral Vaccines / Q000008:administration & dosage / Q000276:immunology / Q000627:therapeutic use*
D019496:Cancer Vaccines; D050725:Papillomavirus E7 Proteins; D014765:Viral Vaccines; C059731:oncogene protein E7, Human papillomavirus type 16