[Retrospective study of dysfunction transplant nephrectomy from a single-center within 10 years].
OBJECTIVE
To find the reasons for dysfunction in renal graft.


METHODS
A total of 27 patients with failed allografted kidneys underwent transplant  nephrectomy from 2001 to 2010. The patients' data were collected separately. The pathologic diagnosis was made according to the Banff 2009 standard.


RESULTS
All the operations were successful. The pathologic reports showed that 15 cases were acute rejection complicated with other factors (1 case  was infected by Bacillus tuberculosis, 2 by mold, and 1 with IgA, 6 were found thrombus in operation), 6 cases were chronic rejection complicated with other  factors [2 cases were acute rejection, and 2 cases were posttransplantation lymphoproliferative disorders (PTLD)], 4 cases were end-stage renal  graft, and 2 PTLD alone. A total of 13 cases were human leukocyte antigen (HLA) mismatch, of which, 11 were confirmed as rejection.


CONCLUSIONS
Rejection complicated with other factors is the most important reason for dysfunction in renal graft, such as thrombus and infection. HLA mismatch may  cause the rejection. End-stage renal graft or PTLD also has an important position in the reason for nephrograft dysfunction.
Department of Urology, Peking University Third Hospital, Beijing, China.
Min
M
Qiu
Min
M
Lu
Lu-lin
LL
Ma
Xiao-fei
XF
Hou
Guo-liang
GL
Wang
Lei
L
Zhao
D000293:Adolescent; D000328:Adult; D002681:China / Q000453:epidemiology; D051799:Delayed Graft Function / Q000209:etiology* / Q000503:physiopathology; D005260:Female; D006084:Graft Rejection / Q000473:pathology / Q000503:physiopathology*; D006801:Humans; D016030:Kidney Transplantation / Q000009:adverse effects*; D008232:Lymphoproliferative Disorders / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D009392:Nephrectomy; D055031:Primary Graft Dysfunction / Q000209:etiology / Q000503:physiopathology; D012189:Retrospective Studies; D055815:Young Adult