Does periprostatic local anesthesia for prostate biopsy affect the operative difficulty of open radical prostatectomy? A prospective randomized trial.
OBJECTIVE
Periprostatic local anesthesia for transrectal ultrasound (TRUS)-guided prostate biopsy requires additional needle punctures and injection of local anesthetics into the periprostatic area. This study sought to determine the influence of periprostatic local anesthesia on the surgical difficulty of open radical prostatectomy (RP).


METHODS
A total of 241 consecutive patients who underwent TRUS-guided prostate needle biopsy were randomized to receive either periprostatic nerve block (Anesthesia group; n=120) or no anesthesia (Control group; n=121). After diagnosing localized prostate cancer, patients who underwent open RP without neoadjuvant androgen deprivation therapy were evaluated as to whether perioperative nerve block affected operative duration, estimated blood loss (EBL), positive margin rate or complications.


RESULTS
Twenty-one patients in the Anesthesia group and 19 patients in the Control group were investigated in the current study. In assessing the patients who underwent open RP with or without periprostatic nerve block, no significant differences in operative duration, EBL, positive margin rate or complications were seen between groups.


CONCLUSIONS
Periprostatic nerve block does not appear to affect perioperative outcomes after open RP.
Department of Urology, Fukushima Medical University School of Medicine, 1 Hikarigaoka, Fukushima, 960-1295, Japan. pessoco@fmu.ac.jp
Nobuhiro
N
Haga
Ken
K
Aikawa
Kei
K
Ishibashi
Tomohiko
T
Yanagida
Norio
N
Takahashi
Souichiro
S
Ogawa
Toshiki
T
Oguro
Masao
M
Kataoka
Chiharu
C
Irisawa
Yoshiyuki
Y
Kojima
D000368:Aged; D000369:Aged, 80 and over; D000772:Anesthesia, Local; D001707:Biopsy, Needle; D006801:Humans; D008297:Male; D008875:Middle Aged; D009407:Nerve Block; D011446:Prospective Studies; D011467:Prostate / Q000473:pathology*; D011468:Prostatectomy / Q000009:adverse effects; D011471:Prostatic Neoplasms / Q000473:pathology* / Q000601:surgery*