E-cadherin expression as a prognostic factor in transitional cell carcinoma of the bladder after transurethral resection.
OBJECTIVE
To analyze the role of negative versus positive immunoexpression of E-cadherin in recurrence rate of low-grade bladder tumors.


METHODS
A total of 180 patients with unifocal, superficial, low-grade, papillary transitional cell carcinoma of the bladder were included in this study. The E-cadherin expression was evaluated using E-cadherin antibody. The patients were followed up for 36 months. Thereafter, recurrence rate of the tumor was compared between E-cadherin positive and negative groups.


RESULTS
Of 180 low-grade carcinomas, E-cadherin immunoexpression was negative in 101 (56%) and positive in 79 (44%) patients. The recurrence rate in negative and positive groups was 65.6% and 37.9%, respectively. Negative in comparison with positive E-cadherin expression was associated with more disease recurrence (P = .045).


CONCLUSIONS
There is an association between decreased E-Cadherin immunoexpression and tumor recurrence in low-grade and non-muscle invasive transitional cell carcinoma of the bladder.
Department of Urology, Alzahra Hospital, Isfahan University of Medical Sciences, Isfahan, Iran.
Mohammad Hatef
MH
Khorrami
Mazaher
M
Hadi
Mohammad Reza
MR
Gharaati
Mohammad Hossein
MH
Izadpanahi
Amir
A
Javid
Mahtab
M
Zargham
D014408:Biomarkers, Tumor / Q000378:metabolism*; D015820:Cadherins / Q000378:metabolism*; D002295:Carcinoma, Transitional Cell / Q000378:metabolism* / Q000473:pathology / Q000601:surgery; D018450:Disease Progression; D005260:Female; D005500:Follow-Up Studies; D015870:Gene Expression; D006801:Humans; D008297:Male; D009364:Neoplasm Recurrence, Local / Q000378:metabolism*; D011379:Prognosis; D001743:Urinary Bladder / Q000378:metabolism* / Q000473:pathology; D001749:Urinary Bladder Neoplasms / Q000378:metabolism* / Q000473:pathology / Q000601:surgery
D014408:Biomarkers, Tumor; D015820:Cadherins