Alkaloids produced by endophytic fungi: a review.
In recent years, a number of alkaloids have been discovered from endophytic fungi in plants, which exhibited excellent biological properties such as antimicrobial, insecticidal, cytotoxic, and anticancer activities. This review mainly deals with the research progress on endophytic fungi for producing bioactive alkaloids such as quinoline and isoquinoline, amines and amides, indole derivatives, pyridines, and quinazolines. The biological activities and action mechanisms of these alkaloids from endophytic fungi are also introduced. Furthermore, the relationships between alkaloid-producing endophytes and their host plants, as well as their potential applications in the future are discussed.
Department of Pharmacognosy, Second Military Medical University, Shanghai 200433, P.R. China.
Yanyan
Y
Zhang
Ting
T
Han
Qianliang
Q
Ming
Lingshang
L
Wu
Khalid
K
Rahman
Luping
L
Qin
D000470:Alkaloids / Q000096:biosynthesis* / Q000737:chemistry*; D060026:Endophytes / Q000378:metabolism*; D005658:Fungi / Q000378:metabolism*; D007546:Isoquinolines / Q000737:chemistry / Q000378:metabolism; D015394:Molecular Structure; D011804:Quinolines / Q000737:chemistry / Q000378:metabolism
D000470:Alkaloids; D007546:Isoquinolines; D011804:Quinolines; C037219:quinoline; C039109:isoquinoline