Rates of fatty acid oxidations by P450 compound I are pH dependent.
The rates of oxidation of fatty acids by CYP119 compound I were dependent on the pH of the medium. The plot shows log k values for reactions of acids as a function of pH, where the slopes indicate mixed third-order and fourth-order dependence on base concentration. For palmitic acid, the rate increased 50-fold over the pH range 6.8-7.3.
Department of Chemistry, University of Illinois at Chicago, 845 W. Taylor St., Chicago, IL 60607, USA.
Zhi
Z
Su
John H
JH
Horner
Martin
M
Newcomb
D019843:Archaeal Proteins / Q000737:chemistry / Q000378:metabolism*; D002210:Caprylates / Q000737:chemistry / Q000378:metabolism; D003577:Cytochrome P-450 Enzyme System / Q000737:chemistry / Q000378:metabolism*; D005227:Fatty Acids / Q000737:chemistry / Q000378:metabolism*; D006863:Hydrogen-Ion Concentration; D007700:Kinetics; D007850:Lauric Acids / Q000737:chemistry / Q000378:metabolism; D010084:Oxidation-Reduction; D019308:Palmitic Acid / Q000737:chemistry / Q000378:metabolism; D013237:Stereoisomerism
D019843:Archaeal Proteins; D002210:Caprylates; D005227:Fatty Acids; D007850:Lauric Acids; C030358:lauric acid; D019308:Palmitic Acid; D003577:Cytochrome P-450 Enzyme System; C408874:CYP119 protein, Sulfolobus solfataricus; C031492:octanoic acid