Facile graft of poly(2-methacryloyloxyethyl phosphorylcholine) onto Fe(3) O(4) nanoparticles by ATRP: synthesis, properties, and biocompatibility.
Magnetite (Fe(3) O(4) ) nanoparticles with the surface hydroxyl groups were achieved by a polyol process. Using 2-(4-chlorosulfonylphenyl) ethyltrichlorosilane (CTCS) as initiator, 2-(methacryloyloxy)ethyl phosphorylcholine (MPC) as monomer, poly(2-(methacryloyloxy)ethyl phosphorylcholine) (PMPC)-grafted Fe(3) O(4) nanoparticles (MNP) were successfully prepared via the atom transfer radical polymerization (ATRP) method. The successful grafting of PMPC on the Fe(3) O(4) nanoparticles surface was ascertained from the FTIR analysis. The modified nanoparticles (MNP-CTCS-PMPC) showed a good biocompatibility in the cytotoxicity test in vitro. Performance testing of MNP-CTCS-PMPC was performed through magnetic resonance analysis (MR), and its r(2) /r(1) value was 24.1. These results indicated that the modified Fe(3) O(4) nanoparticles would be a potential MRI contrast reagent.
Laboratory of Functional and Biomedical Nanomaterials, College of Materials Science and Engineering, Qingdao University of Science and Technology, Qingdao 266042, People's Republic of China.
Xiao-Yan
XY
Sun
Shou-Shan
SS
Yu
Jia-Qi
JQ
Wan
Ke-Zheng
KZ
Chen
D005290:Ferric Compounds / Q000138:chemical synthesis* / Q000737:chemistry*; D006367:HeLa Cells; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D008422:Materials Testing; D008689:Methacrylates / Q000138:chemical synthesis* / Q000737:chemistry*; D053758:Nanoparticles / Q000737:chemistry* / Q000648:ultrastructure; D010767:Phosphorylcholine / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry; D058105:Polymerization; D011109:Polymethacrylic Acids; D012821:Silanes / Q000737:chemistry; D017550:Spectroscopy, Fourier Transform Infrared; D013818:Thermogravimetry; D014961:X-Ray Diffraction
D005290:Ferric Compounds; D008689:Methacrylates; D011109:Polymethacrylic Acids; D012821:Silanes; C115766:poly(2-methacryloyloxyethyl-phosphorylcholine); D010767:Phosphorylcholine; C000499:ferric oxide