An aquatic host-guest complex between a supramolecular G-quadruplex and the anticancer drug doxorubicin.
We describe the synthesis of a fluorescent deoxyguanosine derivative that co-assembles (in water) with an unlabeled analogue into a heteromeric supramolecular G-quadruplex, which forms a host-guest complex with doxorubicin as evidenced by FRET experiments.
Department of Chemistry, University of Puerto Rico Río Piedras Campus, San Juan, PR 00931, USA. jmrivortz@mac.com
José M
JM
Rivera
Mariana
M
Martín-Hidalgo
Jean C
JC
Rivera-Ríos
D000970:Antineoplastic Agents / Q000737:chemistry*; D003849:Deoxyguanosine / Q000031:analogs & derivatives / Q000138:chemical synthesis / Q000737:chemistry; D004317:Doxorubicin / Q000737:chemistry*; D031541:Fluorescence Resonance Energy Transfer; D005456:Fluorescent Dyes / Q000138:chemical synthesis / Q000737:chemistry; D054856:G-Quadruplexes; D046911:Macromolecular Substances / Q000737:chemistry; D008958:Models, Molecular; D015394:Molecular Structure; D013696:Temperature; D014867:Water / Q000737:chemistry
D000970:Antineoplastic Agents; D005456:Fluorescent Dyes; D046911:Macromolecular Substances; D014867:Water; D004317:Doxorubicin; D003849:Deoxyguanosine