Two new asterosaponins from the Far Eastern starfish Lethasterias fusca.
Two new asterosaponins, lethasteriosides A (1) and B (2), were isolated along with previously known thornasteroside A (3), anasteroside A (4), and luidiaquinoside (5) from the ethanolic extract of the Far Eastern starfish Lethasterias fusca. The structures of the new compounds were elucidated by extensive NMR and ESIMS techniques, and chemical transformations. Compounds 1 and 3-5 did not show any apparent cytotoxicity against cancer cell lines T-47D, RPMI-7951, and HCT-116, but glycoside 1, at concentration of 20 microM, demonstrated considerable inhibition of the T-47D (97%), RPMI-795I (90%) and HCT-116 (90%) cell colony formations in a soft agar clonogenic assay.
G.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far Eastern Branch of the Russian Academy of Sciences, Vladivostok, 690022, Russian Federation. ivanchina@piboc.dvo.ru
Natalia V
NV
Ivanchina
Anatoly I
AI
Kalinovsky
Alla A
AA
Kicha
Timofey V
TV
Malyarenko
Pavel S
PS
Dmitrenok
Svetlana P
SP
Ermakova
Valentin A
VA
Stonik
D000818:Animals; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D006027:Glycosides / Q000737:chemistry* / Q000494:pharmacology*; D045325:HCT116 Cells; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D012503:Saponins / Q000737:chemistry* / Q000494:pharmacology*; D013215:Starfish / Q000737:chemistry*
D006027:Glycosides; D012503:Saponins