Beneficial effects of tender coconut water against isoproterenol induced toxicity on heart mitochondrial activities in rats.
Myocardial infarction induced by isoproterenol results in increased mitochondrial lipid peroxidation, decreased activities of carnitine acetyl transferase, acyl CoA dehydrogenase, TCA cycle enzymes and decreased rate of palmitate oxidation into CO2 and ATP formation in the heart in rats. Isoproterenol-induced rats when fed with tender coconut water (West coast tall variety, 5-6 months age) showed improved activities of these mitochondrial enzymes and higher rate of palmitate oxidation into CO2 and ATP production. These results indicate that intake of TCW has a significant beneficial effect on mitochondrial activities.
Department of Biochemistry, University of Kerala, Kariavattom, Thiruvananthapuram 695 581, India.
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P
Anurag
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Rajamohan
D000818:Animals; D001628:Beverages; D003059:Cocos / Q000737:chemistry*; D019610:Cytoprotection / Q000187:drug effects*; D007545:Isoproterenol / Q000633:toxicity*; D008297:Male; D008929:Mitochondria, Heart / Q000187:drug effects* / Q000378:metabolism; D009206:Myocardium / Q000166:cytology*; D051381:Rats
D007545:Isoproterenol