MRI correlates of disability in African-Americans with multiple sclerosis.
OBJECTIVE
Multiple sclerosis (MS) in African-Americans (AAs) is characterized by more rapid disease progression and poorer response to treatment than in Caucasian-Americans (CAs). MRI provides useful and non-invasive tools to investigate the pathological substrate of clinical progression. The aim of our study was to compare MRI measures of brain damage between AAs and CAs with MS.


METHODS
Retrospective analysis of 97 AAs and 97 CAs with MS matched for age, gender, disease duration and age at MRI examination.


RESULTS
AA patients had significantly greater T2- (p = 0.001) and T1-weighted (p = 0.0003) lesion volumes compared to CA patients. In contrast, measurements of global and regional brain volume did not significantly differ between the two ethnic groups (p>0.1).


CONCLUSIONS
By studying a quite large sample of well demographically and clinically matched CA and AA patients with a homogeneous MRI protocol we showed that higher lesion accumulation, rather than pronounced brain volume decrease might explain the early progress to ambulatory assistance of AAs with MS.
Department of Neurology, Langone Medical Center, New York, New York, United States of America.
Jonathan
J
Howard
Marco
M
Battaglini
James Scott
JS
Babb
Donatello
D
Arienzo
Brigitte
B
Holst
Mirza
M
Omari
Nicola
N
De Stefano
Joseph
J
Herbert
Matilde
M
Inglese
D000328:Adult; D001741:Black or African American; D001921:Brain / Q000473:pathology; D004185:Disability Evaluation; D006233:Persons with Disabilities; D018450:Disease Progression; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D009103:Multiple Sclerosis / Q000175:diagnosis*; D009929:Organ Size; D012189:Retrospective Studies; D044465:White People; D055815:Young Adult