Correlation of Cyr61 and CTGF in placentas from  the late pre-eclamptic pregnancy.
It is thought that a shallow invasion of the maternal decidua by extravillous trophoblasts (EVT) is associated with the development of pre-eclampsia. Here, we focus on the expression of the proangiogenic proteins Cyr61 and CTGF in the human placenta during normal pregnancy compared with that in the late pre-eclamptic placenta. Cyr61 and CTGF are expressed in the extravillous trophoblast and in endothelial cells. We found the expression of Cyr61 was significantly decreased in pre-eclamptic placentas compared with matched controls. In contrast, the CTGF expression level was upregulated in pre-eclamptic placentas. There was a negative correlation between Cyr61 and CTGF. These results suggest that decreased Cyr61 and overexpressed CTGF may play a part in the development of pre-eclampsia.
Department of Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Xi
X
Chen
Yanyan
Y
Liu
Xiaoyan
X
Xu
Hanping
H
Chen
D055513:Connective Tissue Growth Factor / Q000032:analysis* / Q000235:genetics; D055515:Cysteine-Rich Protein 61 / Q000032:analysis* / Q000235:genetics; D005260:Female; D005865:Gestational Age; D006801:Humans; D010920:Placenta / Q000737:chemistry*; D016133:Polymerase Chain Reaction; D011225:Pre-Eclampsia / Q000378:metabolism*; D011247:Pregnancy; D012333:RNA, Messenger / Q000032:analysis
C501848:CCN1 protein, human; C526317:CCN2 protein, human; D055515:Cysteine-Rich Protein 61; D012333:RNA, Messenger; D055513:Connective Tissue Growth Factor