A randomized controlled trial assessing the effects of raltegravir intensification on endothelial function in treated HIV infection.
OBJECTIVE
To determine whether intensification with raltegravir improves endothelial function in antiretroviral-treated HIV-infected individuals.


METHODS
: Randomized, double-blinded, placebo-controlled study.


METHODS
Fifty-six subjects with treatment-mediated viral suppression for at least 1 year were randomized to add 400 mg of raltegravir twice daily or matching placebo for 24 weeks. The primary endpoint was the difference in rate of change in endothelial function [as assessed by flow-mediated vasodilation (FMD) of the brachial artery] from baseline to week 24 between the raltegravir and placebo groups. Linear mixed models were used to evaluate the association of treatment group with changes in FMD, immune activation, and measures of viral persistence.


RESULTS
At baseline, the median CD4 T-cell count was 498 cells/mm, nadir CD4 T-cell count was 191 cells/mm, duration of HIV infection was 18 years, FMD was 3.3%, and hyperemic velocity (a marker of microvascular function) was 68.3 cm. There were no significant differences between treatment groups in rate of change in FMD (raltegravir group: +0.032% per week, placebo group: +0.023% per week; P = 0.60). There were also no differences between treatment groups in rate of change in hyperemic velocity, immune activation, or viral persistence. In multivariable analysis, older age, longer duration of HIV infection, and current abacavir use were associated with lower FMD. Lower CD4 T-cell count and current abacavir use were associated with lower hyperemic velocity.


CONCLUSIONS
The addition of raltegravir to suppressive antiretroviral therapy did not have a significant impact on cardiovascular risk, as assessed by endothelial function (ClinicalTrials.gov NCT00843713).
Department of Medicine, University of California, San Francisco, CA, USA. hhatano@php.ucsf.edu
Hiroyu
H
Hatano
Rebecca
R
Scherzer
Yuaner
Y
Wu
Kara
K
Harvill
Kristinalisa
K
Maka
Rebecca
R
Hoh
Elizabeth
E
Sinclair
Sarah
S
Palmer
Jeffrey N
JN
Martin
Michael P
MP
Busch
Steven G
SG
Deeks
Priscilla Y
PY
Hsue
D023241:Antiretroviral Therapy, Highly Active / Q000009:adverse effects / Q000379:methods; D018791:CD4 Lymphocyte Count; D004311:Double-Blind Method; D004730:Endothelium, Vascular / Q000187:drug effects* / Q000503:physiopathology; D005260:Female; D015658:HIV Infections / Q000188:drug therapy* / Q000503:physiopathology; D019428:HIV Integrase Inhibitors / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011760:Pyrrolidinones / Q000627:therapeutic use*; D000068898:Raltegravir Potassium; D014664:Vasodilation / Q000187:drug effects / Q000502:physiology; D019562:Viral Load / Q000187:drug effects
D019428:HIV Integrase Inhibitors; D011760:Pyrrolidinones; D000068898:Raltegravir Potassium