Solubilization of the photosensitizers TPCS(2a) and TPPS(2a) in aqueous media evaluated by time-resolved fluorescence analysis.
The pH-dependent aggregation of the novel photosensitizer TPCS(2a) is investigated at low concentration (c = 10(-6) M) in aqueous media by means of time-correlated single-photon counting, and compared to that of the chemically related photosensitizer TPPS(2a). The efficacy of selected solubilizers, i.e., various nonionic Pluronic block copolymers and the nonionic surfactant Tween 80, in inhibiting aggregation of the two photosensitizers is evaluated, which is important for the further formulation of TPCS(2a).
Department of Physics and Mathematics, University of Insubria at Como, Italy.
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Nardo
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Kristensen
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Tønnesen
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Høgset
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Lilletvedt
D000465:Algorithms; D005079:Excipients; D006863:Hydrogen-Ion Concentration; D007700:Kinetics; D017319:Photosensitizing Agents / Q000737:chemistry*; D020442:Poloxamer; D011136:Polysorbates; D011166:Porphyrins / Q000737:chemistry*; D012995:Solubility; D012996:Solutions; D013050:Spectrometry, Fluorescence; D014867:Water
D005079:Excipients; D017319:Photosensitizing Agents; D011136:Polysorbates; D011166:Porphyrins; D012996:Solutions; C559366:meso-tetraphenyl chlorin disulphonate; D014867:Water; D020442:Poloxamer