Parkinsonian syndrome as a complication of systemic lupus erythematosus. Report of a case and review of the literature.
A 34-year-old woman has had systemic lupus erythematosus since 11 years, with multiple treatments and incomplete result. When examined in our department, she presented with a recent parkinsonian syndrome including bradykinesia, adiadochokinesia, cogwheel rigidity and postural tremor of hands. Deep tendon reflexes were increased. Brain MRI showed abnormal signal intensity in the periventricular white matter, internal capsule, brain stem, middle cerebellar peduncles and cerebellar hemispheres. She was treated with prednisone and mycophenolate for the lupus, and amantadine and benzhexol for the parkinsonian syndrome which resolved within ten months, while the lupus improved. There are 30 cases of Parkinson's disease as a complication of lupus reported in the literature. The pathogenesis may be cerebral vasculitis with ischemia, and antibodies against neurons, mainly dopaminergic. Twenty cases improved, eight of them with the treatment of the lupus alone.
Department of Neurology, Hôtel-Dieu de France Hospital, University Medical Center, Beirut, Lebanon. chemalyre@dm.net.lb
Raymond E
RE
Chemaly
Aïda S
AS
Moussalli
D000328:Adult; D001921:Brain / Q000473:pathology; D005260:Female; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000150:complications*; D008279:Magnetic Resonance Imaging; D020734:Parkinsonian Disorders / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology*