Immunoexpression of α2β1, α3β1, and α5β1 integrins in pleomorphic adenoma and adenoid cystic carcinoma.
The aim of the present study was to compare the expression of α2β1, α3β1, and α5β1 integrins between 28 pleomorphic adenomas (PAs) and 10 adenoid cystic carcinomas (ACCs), and investigate differences in the expression of these integrins according to histologic subtypes of ACCs. It was taken into consideration the presence or absence, distribution, and localization of integrin immunoexpression. There was immunoreactivity in the intercellular contacts of the strands, nests, and solid sheets of PAs, as well as in the luminal and nonluminal cells of the duct-like structures, with a predominant immunoexpression in the luminal cells. The immunoexpression in ACCs varied with histologic subtype of the tumor. It was verified for a tendency of absence and/or reduced expression of all integrins in the solid subtype of ACCs. In general, PAs revealed a more diffuse and remarkable immunoexpression of all studied integrins than ACCs. The reduced integrins expression in ACC may be related to a lesser degree of cell differentiation in this neoplasm. Moreover, the absence and/or reduced expression of the studied integrins in solid ACC suggest a possible role in pathogenesis and more aggressive biological behavior of this histologic subtype.
Department of Oral Pathology, Dentistry School, Federal University of Rio Grande do Norte, Rio Grande do Norte, Brazil.
Márcia Cristina da C
MC
Miguel
Joabe
J
dos Santos Pereira
Emanuel S
ES
de Souza Andrade
Leão
L
Pereira-Pinto
Roseana
R
de Almeida Freitas
Lélia B
LB
de Souza
D008949:Adenoma, Pleomorphic / Q000175:diagnosis / Q000235:genetics* / Q000473:pathology; D014408:Biomarkers, Tumor / Q000235:genetics*; D003528:Carcinoma, Adenoid Cystic / Q000175:diagnosis / Q000235:genetics* / Q000473:pathology; D015870:Gene Expression; D006801:Humans; D007150:Immunohistochemistry; D038982:Integrin alpha2beta1 / Q000235:genetics*; D039201:Integrin alpha3beta1 / Q000235:genetics*; D039081:Integrin alpha5beta1 / Q000235:genetics*; D012468:Salivary Gland Neoplasms / Q000175:diagnosis / Q000235:genetics* / Q000473:pathology
D014408:Biomarkers, Tumor; D038982:Integrin alpha2beta1; D039201:Integrin alpha3beta1; D039081:Integrin alpha5beta1