[The psoriasis--metabolic syndrome comorbidity, a complex multigenic disease].
Psoriasis is a common chronic inflammatory dermatitis mediated by cytokines released by dendritic plasmacytoid cells in combination with Th1- and Th17-cells. This complex and multifactorial condition is commonly associated with some comorbidities. The complexity of a coordinated management of such intricated pathologies is obvious. It calls for the so-called medicine "centered around the patient" which tops off the evidence-based medicine. Vitamin D by its immunomodulatory effect on T helper cells exerts a therapeutic benefit on psoriasis and some of its comorbidities including the metabolic syndrome. A vitamin D oral treatment was proposed in order to reduce the cardiovascular risk, and the ensuing morbidity and mortality.
Service de Dermatopathologie, CHU de Liège, Belgique. claudine.franchimont@ulg.ac.be
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Piérard-franchimont
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Quatresooz
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Piérard
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Scheen
D015984:Causality; D015897:Comorbidity; D004777:Environment; D059647:Gene-Environment Interaction; D020022:Genetic Predisposition to Disease; D006801:Humans; D024821:Metabolic Syndrome / Q000150:complications* / Q000453:epidemiology* / Q000235:genetics; D020412:Multifactorial Inheritance; D011565:Psoriasis / Q000150:complications* / Q000453:epidemiology* / Q000235:genetics; D012307:Risk Factors