Renal cortical necrosis following a colonoscopy.
A 76-year old African-American male presented with profound renal failure within 2 weeks after a screening colonoscopy. Polyethylene glycol (PEG) was the sole oral preparatory agent. The significantly elevated lactate dehydrogenase (LDH) and biopsy findings were consistent with acute renal cortical necrosis (RCN). PEG is associated with AKI, but the exact mechanism is uncertain. PEG can be biodegraded to diethylene glycol (DEG), which is a nephrotoxic agent associated with RCN. Three months after presentation, the patient remains hemodialysis dependent.
Department of Medicine, University of Aleppo, Aleppo, Syria.
Muhammad
M
Hammadah
Lillian
L
Gaber
Rajeev
R
Raghavan
D058186:Acute Kidney Injury / Q000175:diagnosis / Q000209:etiology*; D000368:Aged; D001706:Biopsy; D003113:Colonoscopy / Q000009:adverse effects*; D003937:Diagnosis, Differential; D006801:Humans; D007672:Kidney Cortex / Q000473:pathology*; D007673:Kidney Cortex Necrosis / Q000150:complications / Q000175:diagnosis*; D008297:Male