Incidence of congenital hypothyroidism in the city of Uberaba/Minas Gerais and etiological evaluation of the affected subjects.
OBJECTIVE
The objective of this study was to determine the incidence and etiology of congenital hypothyroidism (CH) in Uberaba, MG.


METHODS
From 2001 to 2010, by reviewing patient files from a public reference outpatient unit. The screening program covered 88% of live-born children.


RESULTS
CH was diagnosed in 16 children, representing an incidence of 1:2,017 live-born children screened. The etiological evaluation was done in 15 children and revealed seven cases of thyroid dysgenesis, seven of dyshormonogenesis, and one case of transient hypothyroidism. One child moved away from the state before etiological investigation was carried out.


CONCLUSIONS
We concluded that both the incidence of CH and of dyshormonogenesis as the main causes of CH were increased in the investigated region, but molecular studies are necessary for a better definition of etiology.
Disciplina de Endocrinologia, Universidade Federal do Triângulo Mineiro, Uberaba, MG, Brasil. helomcp@terra.com.br
Heloísa Marcelina da Cunha
HM
Palhares
Lilian Carla
LC
Silva
Luciene Mayumi
LM
Sato
Beatriz Hallal Jorge
BH
Lara
Sybele de Souza Castro
Sde S
Miranzi
Adriana de Paula
Ade P
Silva
Maria de Fátima
Mde F
Borges
D001938:Brazil / Q000453:epidemiology; D003409:Congenital Hypothyroidism / Q000453:epidemiology* / Q000209:etiology / Q000628:therapy; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D015994:Incidence; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D015997:Neonatal Screening; D010044:Outpatient Clinics, Hospital / Q000706:statistics & numerical data; D012189:Retrospective Studies; D050033:Thyroid Dysgenesis / Q000150:complications; D013961:Thyroid Gland / Q000000981:diagnostic imaging; D013972:Thyrotropin / Q000097:blood; D014463:Ultrasonography
D013972:Thyrotropin