[Norovirus gastroenteritis in adult].
Noroviruses cause epidemic and sporadic acute gastroenteritis in both children and adults. There is a wide range of genetic diversity among the noroviruses, which are subdivided into genogroups and further classified into genotypes. The onset of illness is typically abrupt and often includes vomiting and diarrhea. Fever is present in approximately half of patients. Although short duration of illness is characteristic, it can be severe and fatal among the patient with underlying illness. RT-PCR is currently the mainstay of diagnosis, but not clinical routine. Infectious dose is relatively low and secondary attack rates are high. Controlling outbreaks of norovirus are major challenges. Norovirus virus-like particle vaccine may provide protection against infection after challenge with a homologous virus.
Department of Infectious Disease, Sendai City Hospital.
Akio
A
Kanda
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D017250:Caliciviridae Infections; D004196:Disease Outbreaks / Q000517:prevention & control; D005759:Gastroenteritis / Q000175:diagnosis / Q000517:prevention & control / Q000628:therapy / Q000821:virology*; D005838:Genotype; D006801:Humans; D017053:Infection Control; D008875:Middle Aged; D029322:Norovirus / Q000235:genetics / Q000472:pathogenicity; D020133:Reverse Transcriptase Polymerase Chain Reaction; D014765:Viral Vaccines
D014765:Viral Vaccines