Synthesis of hetero-polymer functionalized nanocarriers by combining surface-initiated ATRP and RAFT polymerization.
Smart nanocarriers are created based on a bi-functional hetero-initiator for RAFT and ATRP technique, bi-functionalizing mesoporous silica nanoparticles with two polymer types. The pH-dependent behavior of PDEAEMA as the gatekeeper polymer is verified by electrokinetic measurements and a controlled release behavior is demonstrated using doxorubicin as the drug.
Leibniz Institute of Polymer Research Dresden, Dresden, Germany.
Xin
X
Huang
Nicole
N
Hauptmann
Dietmar
D
Appelhans
Petr
P
Formanek
Simon
S
Frank
Stefan
S
Kaskel
Achim
A
Temme
Brigitte
B
Voit
D004317:Doxorubicin / Q000737:chemistry / Q000494:pharmacology; D006863:Hydrogen-Ion Concentration; D007700:Kinetics; D008689:Methacrylates / Q000737:chemistry; D053758:Nanoparticles / Q000737:chemistry*; D009705:Nucleosides / Q000737:chemistry; D009757:Nylons / Q000737:chemistry; D058105:Polymerization; D011108:Polymers / Q000138:chemical synthesis*; D011720:Pyrazoles / Q000737:chemistry; D012822:Silicon Dioxide / Q000737:chemistry; D017550:Spectroscopy, Fourier Transform Infrared; D013499:Surface Properties
D008689:Methacrylates; D009705:Nucleosides; D009757:Nylons; D011108:Polymers; D011720:Pyrazoles; C109846:poly(2-(diethylamino)ethyl methacrylate); D012822:Silicon Dioxide; D004317:Doxorubicin; C056881:4-amino-3-(2,3,5-tri-O-benzyl-beta-ribofuranosyl)-5-pyrazole carbonitrile