Aryl amide derivatives of 4-(4-aminopiperidin-1-yl)-7H-pyrrolo[2,3-d]pyrimidine derivatives useful as ASK1 inhibitors, an evaluation of WO2012080735.
Novel 4-(4-aminopiperidin-1-yl)-7H-pyrrolo[2,3-d]pyrimidine derivatives and their salts, compositions containing them and their use as ASK1 inhibitors in the treatment of inflammation and pain are claimed. The compounds have a broad potential utility with osteoarthritis and neuropathic pain among the likely preferred indications.
Norman Consulting, 18 Pink Lane, Burnham, Bucks SL1 8JW, UK. peter.norman2@btinternet.com
Peter
P
Norman
D000577:Amides / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D000700:Analgesics / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D015195:Drug Design; D006801:Humans; D048848:MAP Kinase Kinase Kinase 5 / Q000037:antagonists & inhibitors* / Q000378:metabolism; D015394:Molecular Structure; D009437:Neuralgia / Q000188:drug therapy / Q000201:enzymology; D010003:Osteoarthritis / Q000188:drug therapy / Q000201:enzymology; D010330:Patents as Topic; D011487:Protein Conformation; D047428:Protein Kinase Inhibitors / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D011743:Pyrimidines / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D013329:Structure-Activity Relationship
D000577:Amides; D000700:Analgesics; D000893:Anti-Inflammatory Agents; D047428:Protein Kinase Inhibitors; D011743:Pyrimidines; D048848:MAP Kinase Kinase Kinase 5