Preinjury beta blocker usage does not affect the heart rate response to initial trauma resuscitation.
BACKGROUND
The effect of preinjury beta blockade on heart rate during initial trauma resuscitation is unclear. We hypothesized that preinjury beta blockade does not affect the heart rate response to initial trauma resuscitation.


METHODS
A case-control study of patients admitted to a level I trauma center was conducted. Medical records were reviewed for demographics, medications, injury information, and hemodynamic profiles. Logistic regression identified correlations between preinjury beta blockade and hemodynamics during initial trauma resuscitation and in-hospital mortality.


RESULTS
There were 76 deaths (cases) and 304 survivors (controls). Mean pre-resuscitation heart rate was 83 in patients on beta blocker and 89 in patients not on beta blocker (p=0.007). Mean post-resuscitation heart rate was 80 in patients on beta blocker and 85 in patients not on beta blocker (p=0.02). Tachycardia was present in 14.3% with preinjury beta blocker and 29.7% without (p=0.009). Bradycardia was present in 7.1% with preinjury beta blocker and 2.3% without (p=0.035). Of all patients who presented with an abnormal heart rate, 46% of patients on beta blocker attained a normal heart rate after resuscitation vs. 53% of patients not on beta blocker (p=not significant).


CONCLUSIONS
Preinjury beta blockade is associated with a slower presenting heart rate, more bradycardia, less tachycardia, but no difference in mortality or ability to achieve a normal heart rate with resuscitation.
Brigham and Women's Hospital, Department of Surgery, Division of Trauma, Burns and Surgical Critical Care, 75 Francis Street, Boston, MA 02115, USA. jhavens@partners.org
Joaquim M
JM
Havens
Cullen
C
Carter
Xiangmei
X
Gu
Selwyn O
SO
Rogers
D000319:Adrenergic beta-Antagonists / Q000008:administration & dosage* / Q000009:adverse effects; D000368:Aged; D001145:Arrhythmias, Cardiac / Q000188:drug therapy; D016022:Case-Control Studies; D005260:Female; D006339:Heart Rate / Q000187:drug effects*; D006801:Humans; D008297:Male; D008875:Middle Aged; D012151:Resuscitation / Q000379:methods*; D012307:Risk Factors; D014193:Trauma Centers; D016896:Treatment Outcome; D014947:Wounds and Injuries / Q000503:physiopathology* / Q000628:therapy*
D000319:Adrenergic beta-Antagonists