An unusual conformational similarity of two peptide folds featuring sulfonamide and carboxamide on the backbone.
Two folded peptides featuring carboxamide and sulfonamide at the core of the peptide fold have been shown to possess almost similar conformational features, despite the well-known fact that carboxamides and sulfonamides have strikingly different hydrogen-bonding and geometrical preferences.
Division of Organic Synthesis, National Chemical Laboratory, Dr. Homi Bhabha Road, Pune 411 008, India.
Kuruppanthara N
KN
Vijayadas
Hilda C
HC
Davis
Amol S
AS
Kotmale
Rupesh L
RL
Gawade
Vedavadi G
VG
Puranik
Pattuparambil R
PR
Rajamohanan
Gangadhar J
GJ
Sanjayan
D000577:Amides / Q000737:chemistry*; D018360:Crystallography, X-Ray; D008958:Models, Molecular; D015394:Molecular Structure; D010455:Peptides / Q000737:chemistry*; D011487:Protein Conformation; D017510:Protein Folding; D013449:Sulfonamides / Q000737:chemistry*
D000577:Amides; D010455:Peptides; D013449:Sulfonamides