High-resolution CT vascular imaging using blood pool contrast agents.
While the evolution of computed tomography imaging in the last 2 decades has been driven almost exclusively by improvements in the instrumentation and processing algorithms, there have been comparatively modest advances in contrast agent technology.A notable change in the last decade has been the development of blood pool contrast agents based on nanoparticle technology.While not yet ready for clinical use, the stable and uniform opacification provided by these agents in normal vasculature and controlled extravasation in compromised vasculature enables novel techniques for imaging and diagnosis of pathologies. This manuscript presents preclinical examples demonstrating cardiovascular pathologies and tumor characterization by high-resolution computed tomography imaging.
Singleton Department of Pediatric Radiology, Texas Children’s Hospital, Houston, TX, USA.
Ananth V
AV
Annapragada
Eric
E
Hoffman
Abhay
A
Divekar
Efstathios
E
Karathanasis
Ketan B
KB
Ghaghada
D000818:Animals; D002309:Cardiology / Q000379:methods*; D002318:Cardiovascular Diseases / Q000000981:diagnostic imaging*; D003287:Contrast Media; D006801:Humans; D050997:Nanomedicine; D053758:Nanoparticles; D011237:Predictive Value of Tests; D014057:Tomography, X-Ray Computed; D051598:Whole Body Imaging
D003287:Contrast Media