[Left ventricular function in newborn infants of mothers with gestational diabetes mellitus].
OBJECTIVE
To evaluate left ventricular function in newborn infants of mothers with gestational diabetes mellitus (GDM).


METHODS
Forty newborn infants of mother with GDM (GDM group) and forty normal newborn infants (control group) were enrolled in this study. Two-dimensional speckle tracking imaging was used to measure interventricular septal thickness, posterior left ventricular wall thickness and left ventricular ejection fraction in both groups. Left ventricular rotation and torsion were evaluated for all participants.


RESULTS
Interventricular septal thickness in the GDM group was much higher than in the control group (0.45±0.06 mm vs 0.34±0.05 mm; P<0.05). Posterior left ventricular wall thickness in the GDM group was also higher than in the control group (0.45±0.17 mm vs 0.31±0.02 mm; P<0.05). There was no difference in the left ventricular ejection fraction between the two groups (P>0.05). Peak subendocardial rotation, peak subepicardial rotation, peak bulk rotation and peak mural torsion were higher in the GDM group than in the control group (P<0.05).


CONCLUSIONS
Cardiac function may be impaired in newborn infants of mothers with GDM, with changes in left ventricular shape and abnormalities of left ventricular rotation and torsion. However, infants have a normal ventricular blood ejection under the cardiac compensation. Two-dimensional speckle tracking imaging technique can be used for early detection of left ventricular function.
Houjie Hospital Affiliated to Guangdong Medical College, Dongguan, Guangdong 523945, China. lwqbbb888@163.com
Wei-Qiang
WQ
Liao
Huai-Yuan
HY
Zhou
Guan-Chun
GC
Chen
Min
M
Zou
Xing
X
Lv
D016640:Diabetes, Gestational / Q000503:physiopathology*; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D011247:Pregnancy; D013318:Stroke Volume; D016277:Ventricular Function, Left