Addressing the medicinal chemistry bottleneck: a lean approach to centralized purification.
The use of standardized lean manufacturing principles to improve drug discovery productivity is often thought to be at odds with fostering innovation. This manuscript describes how selective implementation of a lean optimized process, in this case centralized purification for medicinal chemistry, can improve operational productivity and increase scientist time available for innovation. A description of the centralized purification process is provided along with both operational and impact (productivity) metrics, which indicate lower cost, higher output, and presumably more free time for innovation as a result of the process changes described.
Bristol-Myers Squibb Company , PO Box 4000, Princeton, New Jersey 08543, United States.
Harold N
HN
Weller
David S
DS
Nirschl
James L
JL
Paulson
Steven L
SL
Hoffman
William H
WH
Bullock
D002626:Chemistry, Pharmaceutical / Q000191:economics / Q000379:methods / Q000458:organization & administration; D055808:Drug Discovery / Q000191:economics* / Q000379:methods / Q000458:organization & administration; D017598:Efficiency, Organizational; D006801:Humans; D004364:Pharmaceutical Preparations / Q000737:chemistry / Q000191:economics* / Q000302:isolation & purification*
D004364:Pharmaceutical Preparations