Biological transformations of steroidal compounds: a review.
Microbial transformation is an important tool for structural modification of organic compounds, especially natural products with complex structures like steroids. It can be used to synthesize chemical structures that are difficult to obtain by ordinary methods and as a model of mammalian metabolism due to similarity between mammalian and microbial enzyme systems. During recent years research has been focused on the structural modifications of bioactive steroids by using various microorganisms, in order to obtain biologically potent compounds with diverse structures. Steroidal compounds are responsible for important biological functions in the cells and manifest a variety of activities. This article covers the microbial transformation of sterols, steroidal hormones and some new types of steroids known as bufadienolides. Emphasis has placed on reporting metabolites that may be of general interest and on the practical aspects of work in the field of microbial transformations. The review covers the literature from 1994 to 2011.
Department of Chemistry and Biochemistry, University of Agriculture, Faisalabad 38040, Pakistan. hnbhatti2005@yahoo.com
Haq Nawaz
HN
Bhatti
Rasheed Ahmad
RA
Khera
D000818:Animals; D001711:Biotransformation; D006728:Hormones / Q000378:metabolism; D006801:Humans; D008829:Microbiology; D013256:Steroids / Q000378:metabolism*; D013261:Sterols / Q000378:metabolism
D006728:Hormones; D013256:Steroids; D013261:Sterols