Ornithine alpha-ketoglutarate modulates the levels of antioxidants and lipid peroxidation products in ammonium acetate treated rats.
The effects of ornithine alpha-ketoglutarate (OKG) on ammonium acetate induced hepatotoxicity were studied in experimental rats. The levels of urea, non-protein nitrogen and thiobarbituric acid reactive substances were significantly increased in ammonium acetate treated rats; but these levels were significantly decreased in ammonium acetate-OKG treated rats. Similar patterns were observed in the levels of free fatty acids, triglycerides and phospholipids. Furthermore, non-enzymatic (reduced glutathione) and enzymatic (glutathione peroxidase, superoxide dismutase and catalase) antioxidants were significantly decreased in ammonium acetate treated rats, when compared with control and were significantly increased in ammonium acetate-OKG treated rats compared to ammonium acetate treatment alone.
Department of Biochemistry, Faculty of Science, Annamalai University, Annamalainagar 608 002, Tamil Nadu, India.
K B
KB
Dakshayani
S
S
Velvizhi
P
P
Subramanian
D000085:Acetates / Q000737:chemistry / Q000494:pharmacology*; D000818:Animals; D000975:Antioxidants / Q000378:metabolism*; D005230:Fatty Acids, Nonesterified / Q000378:metabolism; D005609:Free Radicals; D015971:Gene Expression Regulation, Enzymologic; D015227:Lipid Peroxidation; D008928:Mitochondria / Q000378:metabolism; D008954:Models, Biological; D009952:Ornithine / Q000031:analogs & derivatives* / Q000502:physiology; D051381:Rats; D017208:Rats, Wistar; D017392:Thiobarbituric Acid Reactive Substances
D000085:Acetates; D000975:Antioxidants; D005230:Fatty Acids, Nonesterified; D005609:Free Radicals; D017392:Thiobarbituric Acid Reactive Substances; C002118:ornithine alpha-ketoglutarate; D009952:Ornithine; C018824:ammonium acetate