The fate of influenza A virus after infection of human macrophages and dendritic cells.
Airway macrophages (MΦ) and dendritic cells (DC) are important components of the innate host defence. Historically, these immune cells have been considered to play a critical role in controlling the severity of influenza A virus (IAV) infection by limiting virus release, initiating local inflammatory responses and by priming subsequent adaptive immune responses. However, some IAV strains have been reported to replicate productively in human immune cells. Potential amplification and dissemination of IAV from immune cells may therefore be an important virulence determinant. Herein, we will review findings in relation to the fate of IAV following infection of MΦ and DC. Insights regarding the consequences and outcomes of IAV infection of airway MΦ and DC are discussed in order to gain a better understanding of the pathogenesis of influenza virus.
Department of Microbiology and Immunology, The University of Melbourne, Parkville, Victoria 3010, Australia.
Kirsty R
KR
Short
Department of Microbiology and Immunology, The University of Melbourne, Parkville, Victoria 3010, Australia.
Andrew G
AG
Brooks
WHO Collaborating Centre for Reference and Research on Influenza, Victorian Infectious Diseases Reference Laboratory, North Melbourne, Victoria 3051, Australia.|Department of Microbiology and Immunology, The University of Melbourne, Parkville, Victoria 3010, Australia.
Patrick C
PC
Reading
Department of Microbiology and Immunology, The University of Melbourne, Parkville, Victoria 3010, Australia.
Sarah L
SL
Londrigan
D003713:Dendritic Cells / Q000276:immunology* / Q000821:virology*; D006801:Humans; D007113:Immunity, Innate; D009980:Influenza A virus / Q000472:pathogenicity / Q000502:physiology*; D008264:Macrophages / Q000276:immunology* / Q000821:virology*; D012137:Respiratory System / Q000166:cytology