Effects of different pulmonary surfactants in the prevention of postoperative intraabdominal adhesion formation.
BACKGROUND
After abdominal surgery, the formation of postoperative adhesion is a serious problem. The aim of the study is to evaluate the efficacy of 2 different pulmonary surfactants, poractant and beractant, on adhesion prevention in an experimental model.


METHODS
An experimental intraabdominal adhesion model was created in 18 adult female rats by cecal abrasion. The rats were randomly assigned to 3 groups. Group I received no further treatment, whereas groups II and III received intraperitoneal poractant and beractant, respectively, before closing the incision. On the 15th postoperative day, all rats underwent relaparotomy, intraabdominal adhesions were scored macroscopically according to Canbaz scoring system, and the cecum in each animal was evaluated microscopically.


RESULTS
The median adhesion scores of group II and III rats were significantly lower when compared with group I (P = .02). Group III had a lower median adhesion score than did group II, but this did not reach significance (P > .05).


CONCLUSIONS
These observations suggest that intraperitoneal instillation of both pulmonary surfactants is associated with lower adhesion scores, higher adhesion-free cases, and improved histologic findings.
Department of Pediatric Surgery, Neonatal Intensive Care Unit, Zekai Tahir Burak Maternity Teaching Hospital 06230 Cebeci, Ankara, Turkey. dryavuzyilmaz@yahoo.com
Yavuz
Y
Yilmaz
Istemi H
IH
Celik
Arzu
A
Pampal
Gamze
G
Demirel
Ferda
F
Topal
Serife S
SS
Oguz
Sibel S
SS
Kilicoglu
Ibrahim O
IO
Ozen
Ugur
U
Dilmen
D000005:Abdomen / Q000601:surgery*; D000818:Animals; D001688:Biological Products / Q000008:administration & dosage / Q000627:therapeutic use*; D002417:Cattle; D002432:Cecum / Q000293:injuries / Q000473:pathology / Q000601:surgery*; D004353:Drug Evaluation, Preclinical; D005260:Female; D007322:Instillation, Drug; D007813:Laparotomy; D010529:Peritoneal Cavity; D010743:Phospholipids / Q000008:administration & dosage / Q000627:therapeutic use*; D011663:Pulmonary Surfactants / Q000008:administration & dosage / Q000627:therapeutic use*; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar; D013552:Swine; D000267:Tissue Adhesions / Q000209:etiology / Q000517:prevention & control*
D001688:Biological Products; D010743:Phospholipids; D011663:Pulmonary Surfactants; C068291:poractant alfa; C072197:beractant