Resveratrol effects on astrocyte function: relevance to neurodegenerative diseases.
Inflammatory molecules have been implicated in the pathogenesis of neurodegenerative diseases such as Parkinson's disease, Alzheimer's disease, and multiple sclerosis. Resveratrol is an anti-fungal compound found in the skins of red grapes and other fruits and nuts. We examined the ability of resveratrol to inhibit lipopolysaccharide (LPS)-induced production of inflammatory molecules from primary mouse astrocytes. Resveratrol inhibited LPS-induced production of nitric oxide (NO); the cytokines tumor necrosis factor-alpha (TNF-α), interleukin 1-beta (IL-1β), and IL-6; and the chemokine monocyte chemotactic protein-1 (MCP-1), which play critical roles in innate immunity, by astrocytes. Resveratrol also suppressed astrocyte production of IL-12p40 and IL-23, which are known to alter the phenotype of T cells involved in adaptive immunity. Finally resveratrol inhibited astrocyte production of C-reactive protein (CRP), which plays a role in a variety of chronic inflammatory disorders. Collectively, these studies suggest that resveratrol may be an effective therapeutic agent in neurodegenerative diseases initiated or maintained by inflammatory processes.
Department of Biology, Ouachita Baptist University, Arkadelphia, AR 71998, USA.
Randall D
RD
Wight
Cameron A
CA
Tull
Matthew W
MW
Deel
Brooke L
BL
Stroope
Amy G
AG
Eubanks
Janet A
JA
Chavis
Paul D
PD
Drew
Lori L
LL
Hensley
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology* / Q000627:therapeutic use; D001253:Astrocytes / Q000187:drug effects* / Q000276:immunology / Q000473:pathology; D002097:C-Reactive Protein / Q000037:antagonists & inhibitors / Q000378:metabolism; D002478:Cells, Cultured; D018932:Chemokine CCL2 / Q000378:metabolism; D016207:Cytokines / Q000378:metabolism; D053762:Interleukin-12 Subunit p40 / Q000037:antagonists & inhibitors / Q000378:metabolism; D053759:Interleukin-23 / Q000037:antagonists & inhibitors / Q000378:metabolism; D008070:Lipopolysaccharides / Q000276:immunology; D051379:Mice; D019636:Neurodegenerative Diseases / Q000188:drug therapy / Q000276:immunology*; D009569:Nitric Oxide / Q000378:metabolism; D000077185:Resveratrol; D013267:Stilbenes / Q000494:pharmacology* / Q000627:therapeutic use
D000894:Anti-Inflammatory Agents, Non-Steroidal; D018932:Chemokine CCL2; D016207:Cytokines; D053762:Interleukin-12 Subunit p40; D053759:Interleukin-23; D008070:Lipopolysaccharides; D013267:Stilbenes; D009569:Nitric Oxide; D002097:C-Reactive Protein; D000077185:Resveratrol