[Case-control study of risk factors in age-related macular degeneration].
OBJECTIVE
To examine the potential influence factors of age-related macular degeneration (AMD).


METHODS
A nationwide multicenter case-control study conducted between Jan. 2008 and May 2010. A total of 545 AMD patients and 480 controls, aged 50 years or older consented to participate in  the study. Questionnaires were designed to collect information about demographic characteristics (age, gender), family history, disease history, and  behavior factors (smoking, drinking). Moreover, physical examinations, biochemical examinations and ophthalmology examinations were conducted for  each participant.


RESULTS
The subjects who had AMD family history were 4.21 times more likely to have AMD (P<0.001). The subject who had the history  of tracheitis /asthma were 1.87 times more likely to have AMD (P=0.008). Both smoking and drinking were risk factors to AMD (OR= 1.91,P < 0.001;  OR=1.53, P = 0.003, respectively). Total protein (P = 0.004), high-density lipoprotein cholesterol ester (P = 0.016) and apolipoprotein A1 (P = 0.012) were  associated with AMD.


CONCLUSIONS
Family history, smoking, drinking and history of tracheitis /asthma are the risk factors of AMD. Total protein, high-density lipoprotein cholesterol ester and apolipoprotein A1 are associated with AMD.
Department of Epidemiology and Biostatistics, Peking University School of Public Health, Beijing, China.
Jun
J
Tian
Kai
K
Fang
Xue-ying
XY
Qin
Qing
Q
Chen
Jun
J
Li
Wen-zhen
WZ
Yu
Jing
J
Hou
Da-fang
DF
Chen
Yong-hua
YH
Hu
Xiao-xin
XX
Li
D000368:Aged; D000428:Alcohol Drinking; D016022:Case-Control Studies; D002681:China / Q000453:epidemiology; D008076:Cholesterol, HDL / Q000097:blood; D005260:Female; D006801:Humans; D008268:Macular Degeneration / Q000453:epidemiology* / Q000209:etiology; D008297:Male; D008875:Middle Aged; D012307:Risk Factors; D012907:Smoking; D011795:Surveys and Questionnaires
D008076:Cholesterol, HDL