Application of nanogel systems in the administration of local anesthetics.
Nanogels are robust nanoparticles that could be used to deliver active drug compounds in controlled drug delivery applications. This review discusses the design, synthesis, loading, and release of local anesthetics using polymeric nanoparticles produced via various types of polymerization techniques. The strategy of using layer-by-layer approach to control the burst release of procaine hydrochloride (PrHy; a local anesthetic drug of the amino ester group) is described and discussed.
Institute of Bioengineering and Nanotechnology, Agency for Science Technology and Research, Singapore.
Jeremy Pk
JP
Tan
Maureen Bh
MB
Tan
Michael Kc
MK
Tam