Role of 18F-fluoride PET/CT in the assessment of multiple myeloma: initial experience.
OBJECTIVE
The aim of this study was to report our early experience with (18)F-fluoride PET/CT for detecting lesions and evaluate the usefulness of this modality in the assessment of multiple myeloma (MM).


METHODS
(18)F-fluoride PET/CT and (99m)Tc-MDP bone scintigraphy (BS) studies from 7 myeloma patients (4 male and 3 female, mean age 55 years) diagnosed according to standard criteria were reviewed retrospectively. Two reviewers visually and quantitatively analyzed the images and recorded their findings after reaching a consensus. Diagnostic certainty regarding the presence or absence of myeloma lesions was evaluated according to the reference standard consisting of whole-body magnetic resonance imaging and whole-body X-ray.


RESULTS
A total of 93 affected areas were definite according to the reference standard. Of these, 83 affected areas (89 %) were identified on (18)F-fluoride PET/CT, whereas 54 affected areas (58 %) were found on BS. Mean SUVmax in the affected areas was 9.8 ± 3.2 (standard deviation) ranging from 5.0 to 21.2. A total of s17 lesions with bone fracture were also detected by (18)F-fluoride PET/CT and 2 lesions (12 %) were negative on BS.


CONCLUSIONS
Our result showed that (18)F-fluoride PET was a possible modality to detect areas of lesions in patients with MM.
Department of Radiology, Yokohama City University Graduate School of Medicine, Kanazawa-ku, Japan.
Yuji
Y
Nishiyama
Ukihide
U
Tateishi
Kazuya
K
Shizukuishi
Ayako
A
Shishikura
Etsuko
E
Yamazaki
Hiroto
H
Shibata
Tomohiro
T
Yoneyama
Yoshiaki
Y
Ishigatsubo
Tomio
T
Inoue
D005260:Female; D005459:Fluorides; D005462:Fluorine Radioisotopes; D006801:Humans; D008297:Male; D008875:Middle Aged; D064847:Multimodal Imaging; D009101:Multiple Myeloma / Q000000981:diagnostic imaging*; D049268:Positron-Emission Tomography; D012189:Retrospective Studies; D012680:Sensitivity and Specificity; D014057:Tomography, X-Ray Computed
D005462:Fluorine Radioisotopes; D005459:Fluorides