Mean platelet volume and related factors in patients at different stages of diabetic nephropathy: a preliminary study.
BACKGROUND
Mean platelet volume (MPV) is an independent cardiovascular disease predictor, and characteristics of MPV in patients with diabetic nephropathy (DN) are not well known.


OBJECTIVE
To determine the MPV levels in patients at different stages of DN.


METHODS
The MPV levels were investigated in healthy participants (group 1, n = 157), patients with type 2 diabetes mellitus without complication (group 2, n = 160), diabetic patients with clinical proteinuria (group 3, n = 144), and in patients with chronic kidney disease due to DN (group 4, n = 160).


RESULTS
The MPV level was higher in all diabetic patients than that in normal participants (P < .05). The MPV values had a positive correlation with the serum creatinine and proteinuria, and a negative correlation with the glomerular filtration rate ([GFR] P < .001 for all, r values; .72, and .82, and -.92, respectively).


CONCLUSIONS
The MPV values were higher in diabetic groups than that in normal participants. Both GFR and proteinuria were the most powerful determinants of MPV.
1Division of Nephrology, Department of Internal Medicine, School of Medicine, Mersin University, Mersin, Turkey.
Kenan
K
Turgutalp
Onur
O
Özhan
Esen
E
Akbay
Anil
A
Tombak
Naci
N
Tiftik
Turkay
T
Ozcan
Sercan
S
Yilmaz
Ilter
I
Helvaci
Ahmet
A
Kiykim
D016022:Case-Control Studies; D003430:Cross-Sectional Studies; D003924:Diabetes Mellitus, Type 2 / Q000097:blood* / Q000652:urine; D003928:Diabetic Nephropathies / Q000097:blood* / Q000652:urine; D005260:Female; D006801:Humans; D008297:Male; D063847:Mean Platelet Volume; D008875:Middle Aged; D011507:Proteinuria / Q000097:blood