Human cytomegalovirus inhibitor AL18 also possesses activity against influenza A and B viruses.
AL18, an inhibitor of human cytomegalovirus DNA polymerase, was serendipitously found to also block the interaction between the PB1 and PA polymerase subunits of influenza A virus. Furthermore, AL18 effectively inhibited influenza A virus polymerase activity and the overall replication of influenza A and B viruses. A molecular model to explain the binding of AL18 to both cytomegalovirus and influenza targets is proposed. Thus, AL18 represents an interesting lead for the development of new antivirals.
Department of Molecular Medicine, University of Padua, Padua, Italy.
Giulia
G
Muratore
Beatrice
B
Mercorelli
Laura
L
Goracci
Gabriele
G
Cruciani
Paul
P
Digard
Giorgio
G
Palù
Arianna
A
Loregian
D000880:Anthraquinones / Q000737:chemistry / Q000494:pharmacology*; D000998:Antiviral Agents / Q000737:chemistry / Q000494:pharmacology*; D003587:Cytomegalovirus / Q000187:drug effects / Q000201:enzymology; D004259:DNA-Directed DNA Polymerase / Q000737:chemistry / Q000378:metabolism; D004791:Enzyme Inhibitors / Q000737:chemistry / Q000494:pharmacology*; D057809:HEK293 Cells; D006801:Humans; D009980:Influenza A virus / Q000187:drug effects* / Q000201:enzymology; D009981:Influenza B virus / Q000187:drug effects* / Q000201:enzymology; D007251:Influenza, Human / Q000188:drug therapy / Q000821:virology; D062105:Molecular Docking Simulation; D019384:Nucleic Acid Synthesis Inhibitors; D012324:RNA-Dependent RNA Polymerase / Q000037:antagonists & inhibitors* / Q000737:chemistry / Q000378:metabolism; D014162:Transfection; D014764:Viral Proteins / Q000037:antagonists & inhibitors* / Q000737:chemistry / Q000378:metabolism
C580588:AL18 compound; D000880:Anthraquinones; D000998:Antiviral Agents; D004791:Enzyme Inhibitors; D019384:Nucleic Acid Synthesis Inhibitors; C061290:PA protein, influenza viruses; D014764:Viral Proteins; C077346:influenza virus polymerase basic protein 1; D012324:RNA-Dependent RNA Polymerase; D004259:DNA-Directed DNA Polymerase