Hybrid mouse diversity panel: a panel of inbred mouse strains suitable for analysis of complex genetic traits.
We have developed an association-based approach using classical inbred strains of mice in which we correct for population structure, which is very extensive in mice, using an efficient mixed-model algorithm. Our approach includes inbred parental strains as well as recombinant inbred strains in order to capture loci with effect sizes typical of complex traits in mice (in the range of 5% of total trait variance). Over the last few years, we have typed the hybrid mouse diversity panel (HMDP) strains for a variety of clinical traits as well as intermediate phenotypes and have shown that the HMDP has sufficient power to map genes for highly complex traits with resolution that is in most cases less than a megabase. In this essay, we review our experience with the HMDP, describe various ongoing projects, and discuss how the HMDP may fit into the larger picture of common diseases and different approaches.
Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA, USA.
Anatole
A
Ghazalpour
Christoph D
CD
Rau
Charles R
CR
Farber
Brian J
BJ
Bennett
Luz D
LD
Orozco
Atila
A
van Nas
Calvin
C
Pan
Hooman
H
Allayee
Simon W
SW
Beaven
Mete
M
Civelek
Richard C
RC
Davis
Thomas A
TA
Drake
Rick A
RA
Friedman
Nick
N
Furlotte
Simon T
ST
Hui
J David
JD
Jentsch
Emrah
E
Kostem
Hyun Min
HM
Kang
Eun Yong
EY
Kang
Jong Wha
JW
Joo
Vyacheslav A
VA
Korshunov
Rick E
RE
Laughlin
Lisa J
LJ
Martin
Jeffrey D
JD
Ohmen
Brian W
BW
Parks
Matteo
M
Pellegrini
Karen
K
Reue
Desmond J
DJ
Smith
Sotirios
S
Tetradis
Jessica
J
Wang
Yibin
Y
Wang
James N
JN
Weiss
Todd
T
Kirchgessner
Peter S
PS
Gargalovic
Eleazar
E
Eskin
Aldons J
AJ
Lusis
Renée C
RC
LeBoeuf
D000818:Animals; D030541:Databases, Genetic; D051379:Mice; D008815:Mice, Inbred Strains / Q000235:genetics*