A highly sensitive fluorescent viscosity sensor.
Variation at the 3' position of fluorescein via Suzuki-Miyaura cross-coupling with aryl and heteroaryl moieties gave a family of anthofluoresceins whose spectroscopic properties were studied. The 1-methylindole derivative gave the highest quantum yield and was observed to behave as a molecular rotor, displaying marked variations in fluorescent intensities with viscosity and offering possible application in cellular sensing and fluorescent polarisation assays.
School of Chemical Sciences and Food Technology, Faculty of Science and Technology, 43600 Universiti Kebangsaan Malaysia, Selangor, Malaysia. rahimi@ukm.my
Rahimi M
RM
Yusop
Asier
A
Unciti-Broceta
Mark
M
Bradley
D005452:Fluoresceins / Q000138:chemical synthesis / Q000737:chemistry*; D005454:Fluorescence Polarization; D005456:Fluorescent Dyes / Q000138:chemical synthesis / Q000737:chemistry*; D006367:HeLa Cells; D006801:Humans; D015394:Molecular Structure; D013050:Spectrometry, Fluorescence; D014783:Viscosity
D005452:Fluoresceins; D005456:Fluorescent Dyes