Comparative genomic analysis of eutherian interferon-γ-inducible GTPases.
The interferon-γ-inducible GTPases, IFGGs, are intracellular proteins involved in immune response against pathogens. A comprehensive comparative genomic review and analysis of eutherian IFGGs was carried out using public genomic sequences. The 64 eutherian IFGG genes were examined in detail and annotated. The eutherian IFGG promoter types were first catalogued followed by a phylogenetic analysis of eutherian IFGGs, which described five major IFGG clusters. The patterns of differential gene expansions and protein regions that may regulate IFGG catalytic features suggested a new classification of eutherian IFGGs. This mini-review has also provided new tests of reliability of public genomic sequences as well as tests of protein molecular evolution.
Laboratory of Genomics, Centre of Animal Reproduction, Zagreb, Croatia. mpremzl@yahoo.com
Marko
M
Premzl
D000818:Animals; D002965:Classification; D019143:Evolution, Molecular; D020558:GTP Phosphohydrolases / Q000235:genetics* / Q000378:metabolism; D016678:Genome / Q000235:genetics*; D007371:Interferon-gamma / Q000378:metabolism; D008322:Mammals / Q000235:genetics*; D058977:Molecular Sequence Annotation; D005810:Multigene Family; D010802:Phylogeny
D007371:Interferon-gamma; D020558:GTP Phosphohydrolases