Formulation and development of oral dry suspension using taste masked Ornidazole particles prepared using Kollicoat(®) Smartseal 30 D.
The purpose of this work was to taste mask highly bitter active, Ornidazole by means of particle coating. The aim of the work was further extended into formulating these coated particles into an acceptable oral dosage form such as dry suspension. Ornidazole drug particles were coated using Kollicoat(®) Smartseal 30 D as a taste masking polymer. Kollicoat(®) Smartseal 30 D is a methyl methacrylate - diethylaminoethyl methacrylate copolymer (6:4). Successful taste masking was achieved for Ornidazole with both top spray and bottom spray techniques using fluid bed processor. Effective taste masking was achieved at a weight gain of 50% w/w and 40% w/w for bottom and top spray techniques respectively without having a significant effect on the release pattern. A taste masked dry suspension was prepared with around 80% w/w coated Ornidazole particles and pH was maintained around 7-8. The suspension prepared with these coated Ornidazole particles, which were maintained in the alkaline pH was found to be stable for 7 days without affecting the taste. The bitter taste intensity was evaluated using volunteers by comparison of test samples with standard solutions containing Ornidazole at various concentrations. Thus, Kollicoat(®) Smartseal 30 D was found to be an effective polymer for taste masking of a bitter active like Ornidazole. The formulation development of taste masked dry suspensions was only possible due to unique properties possessed by Kollicoat(®) Smartseal 30 D.
BASF India Ltd, Pharma Ingredients and Services, Turbhe, Navi Mumbai, India.
Amit
A
Chivate
Vishnu
V
Sargar
Pravin
P
Nalawade
Vaishali
V
Tawde
D000284:Administration, Oral; D002626:Chemistry, Pharmaceutical; D006863:Hydrogen-Ion Concentration; D008689:Methacrylates / Q000737:chemistry; D009950:Ornidazole / Q000008:administration & dosage / Q000737:chemistry*; D010316:Particle Size; D012995:Solubility; D013535:Suspensions; D013649:Taste
D008689:Methacrylates; D013535:Suspensions; D009950:Ornidazole; C519537:diethylaminoethyl methacrylate