Late complications of clinical clostridium histolyticum collagenase use in Dupuytren's disease.
BACKGROUND
While Dupuytren's disease can cause disabling contractures requiring open surgery, a less-invasive option using Clostridium Histolyticum collagenase (CHC) via percutaneous injection was recently reported. A recent prospective, randomized trial demonstrated few complications during 90 days follow-up, however did not assess any longer term follow-up for these patients. Long-term outcomes in this setting have not been adequately reported, and the current manuscript aims to identify late complications from the clinical use of percutaneous CHC.


METHODS
The current manuscript reports an extended 12-month follow-up for a cohort of twelve of patients enrolled in the original prospective, randomized trial, treated at a single institution. An analysis of complications requiring surgical intervention was undertaken.


RESULTS
Two of twelve patients reported debilitating pain and triggering requiring surgical intervention. Extensive deep-tissue scarring and adhesions were identified, providing the first visual and qualitative analysis of the pathologic effects of CHC.


CONCLUSIONS
Late complications from CHC use can and have occurred, outside the follow-up period of the initial phase III trials. Longer term follow-up of such patients is thus essential, and further investigation and characterization of the late effects of CHC use is warranted.
Department of Plastic and Reconstructive Surgery, Dandenong Hospital, Southern Health, Dandenong, Victoria, Australia. warrenrozen@hotmail.com
Warren M
WM
Rozen
Yasith
Y
Edirisinghe
John
J
Crock
D002921:Cicatrix; D047009:Hathewaya histolytica / Q000201:enzymology; D015331:Cohort Studies; D004387:Dupuytren Contracture / Q000188:drug therapy* / Q000473:pathology / Q000601:surgery; D005500:Follow-Up Studies; D006227:Hand Deformities, Acquired / Q000188:drug therapy* / Q000473:pathology / Q000601:surgery; D006801:Humans; D008297:Male; D003012:Microbial Collagenase / Q000009:adverse effects* / Q000627:therapeutic use; D010146:Pain; D000267:Tissue Adhesions / Q000209:etiology / Q000601:surgery
D003012:Microbial Collagenase