Structural architecture and functional evolution of Wnts.
The crystal structure of a Wnt morphogen bound to its Frizzled receptor ectodomain provides insights into the evolutionary provenance of this complex fold and offers an explanation for why Wnts utilize both lipid- and protein-mediated contacts to engage Frizzleds.
Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA 94305, USA. jfbazan@gmail.com
J Fernando
JF
Bazan
Claudia Y
CY
Janda
K Christopher
KC
Garcia
D000818:Animals; D051157:Frizzled Receptors / Q000737:chemistry / Q000378:metabolism; D006801:Humans; D008958:Models, Molecular; D020836:Protein Structure, Quaternary; D017434:Protein Structure, Tertiary; D051153:Wnt Proteins / Q000737:chemistry* / Q000378:metabolism
D051157:Frizzled Receptors; D051153:Wnt Proteins