Antioxidation and DNA-binding properties of binuclear lanthanide(III) complexes with a Schiff base ligand derived from 8-hydroxyquinoline-7-carboxaldehyde and benzoylhydrazine.
8-Hydroxyquinoline-7-carboxaldehyde (8-HQ-7-CA), Schiff-base ligand 8-hydroxyquinoline-7-carboxaldehyde benzoylhydrazone, and binuclear complexes [LnL(NO(3))(H(2)O)(2)](2) were prepared from the ligand and equivalent molar amounts of Ln(NO(3))·6H(2)O (Ln=La(3+), Nd(3+), Sm(3+), Eu(3+), Gd(3+), Dy(3+), Ho(3+), Er(3+), Yb(3+), resp.). Ligand acts as dibasic tetradentates, binding to Ln(III) through the phenolate O-atom, N-atom of quinolinato unit, and C=N and -O-C=N- groups of the benzoylhydrazine side chain. Dimerization of this monomeric unit occurs through the phenolate O-atoms leading to a central four-membered (LnO)(2) ring. Ligand and all of the Ln(III) complexes can strongly bind to CT-DNA through intercalation with the binding constants at 10(5)-10(6) M(-1). Moreover, ligand and all of the Ln(III) complexes have strong abilities of scavenging effects for hydroxyl (HO·) radicals. Both the antioxidation and DNA-binding properties of Ln(III) complexes are much better than that of ligand.
College of Chemistry and Chemical Engineering, Key Laboratory of Longdong Biological Resources in Gansu Province, Longdong University, Qingyang, Gansu 745000, PR China. ychliu001@163.com
Yongchun
Y
Liu
Kejun
K
Zhang
Yun
Y
Wu
Junying
J
Zhao
Jianning
J
Liu
D000818:Animals; D000975:Antioxidants / Q000737:chemistry* / Q000494:pharmacology*; D002417:Cattle; D056831:Coordination Complexes / Q000737:chemistry* / Q000494:pharmacology*; D004247:DNA / Q000378:metabolism; D006834:Hydrazines / Q000737:chemistry / Q000494:pharmacology; D017665:Hydroxyl Radical / Q000378:metabolism; D007364:Intercalating Agents / Q000737:chemistry / Q000494:pharmacology; D028581:Lanthanoid Series Elements / Q000737:chemistry* / Q000494:pharmacology*; D008024:Ligands; D015125:Oxyquinoline / Q000737:chemistry / Q000494:pharmacology; D012545:Schiff Bases / Q000737:chemistry / Q000494:pharmacology
D000975:Antioxidants; D056831:Coordination Complexes; D006834:Hydrazines; D007364:Intercalating Agents; D028581:Lanthanoid Series Elements; D008024:Ligands; D012545:Schiff Bases; D017665:Hydroxyl Radical; D015125:Oxyquinoline; D004247:DNA; C427203:calf thymus DNA; C006712:benzoylhydrazine