microRNAs and thyroid cancer: biological and clinical significance (Review).
Despite recent advances in the management of thyroid cancer, the survival             rate of this tumor may still be improved. Therefore, the identification of biological             and molecular features of indolent and aggressive disease would be critical to             define clinically useful predictors of high-risk lesions. microRNAs (miRNAs) are             small RNA molecules with regulatory function and marked tissue specificity that             modulate multiple targets belonging to several pathways. They are frequently deregulated             in cancer and constitute a new class of blood-based biomarkers useful for cancer             detection and prognosis definition, including thyroid cancer. In this review,             the role of miRNAs in thyroid cancer development is described. The most common             miRNAs detected in thyroid cancer along with their clinical significance are also             discussed. Further studies aimed to detect plasma-based miRNA biomarkers in thyroid             cancer patients may provide further insight into the management of thyroid cancer.
Laboratory of Translational Oncology and Functional Genomics,                     Section of Pathology and Oncology, Department of Biomedical Sciences,                     University of Catania, Catania, Italy.
Giulia Costanza
GC
Leonardi
Saverio
S
Candido
Maurizio
M
Carbone
Valeria
V
Colaianni
Sebastiano F
SF
Garozzo
Diana
D
Cinà
Massimo
M
Libra
D000818:Animals; D002277:Carcinoma / Q000235:genetics / Q000378:metabolism*; D002471:Cell Transformation, Neoplastic / Q000235:genetics / Q000378:metabolism; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D035683:MicroRNAs / Q000502:physiology*; D034622:RNA Interference; D013964:Thyroid Neoplasms / Q000235:genetics / Q000378:metabolism*; D059467:Transcriptome
D035683:MicroRNAs