Synthesis and antifungal activity of 1-thia-4b-aza-cyclopenta[b]fluorene-4,10-diones.
1-Thia-4b-aza-cyclopenta[b]fluorene-4,10-diones were synthesized and tested for in vitro antifungal activity against two pathogenic strains of fungi. Among them tested, many compounds showed good antifungal activity. The results suggest that 1-thia-4b-aza-cyclopenta[b]fluorene-4,10-diones would be antifungal agents.
College of Pharmacy & Division of Life and Pharmaceutical Sciences, Ewha Womans University, 52, Ewhayeodae-gil, Seodaemun-ku, Seoul 120-750, Republic of Korea. ckryu@ewha.ac.kr
Chung-Kyu
CK
Ryu
Aram
A
Kim
Hyun Ah
HA
Im
Ji Young
JY
Kim
D000935:Antifungal Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D005449:Fluorenes / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D005658:Fungi / Q000187:drug effects* / Q000254:growth & development; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D013237:Stereoisomerism; D013329:Structure-Activity Relationship
C576765:1-thia-4b-aza-cyclopenta(b)fluorene-4,10-dione; D000935:Antifungal Agents; D005449:Fluorenes