Increased macrophage migration inhibitory factor (MIF) plasma levels in acute HIV-1 infection.
Considering macrophage migratory inhibitory factor (MIF) as a critical pro-inflammatory cytokine of the immune system, we evaluated plasma MIF levels in 89 HIV-infected adults. Plasma MIF levels were higher in HIV-infected than in HIV-negative individuals. Highest MIF levels were observed during acute HIV infection (AHI) whilst patients on antiretroviral therapy (ART) had lower MIF levels, regardless of ART efficacy. Our results suggest that MIF is an integral component of the cytokine storm characteristic of AHI.
Infectious Diseases Service, Department of Medicine, Centre Hospitalier Universitaire Vaudois and University of Lausanne, Lausanne, Switzerland. Julie.Delaloye@chuv.ch
Julie
J
Delaloye
Irma J A
IJ
De Bruin
Katharine E A
KE
Darling
Marlies Knaup
MK
Reymond
Fred C G J
FC
Sweep
Thierry
T
Roger
Thierry
T
Calandra
Matthias
M
Cavassini
D000208:Acute Disease; D000328:Adult; D000368:Aged; D005260:Female; D015658:HIV Infections / Q000097:blood*; D018023:HIV Seronegativity; D006801:Humans; D019746:Intramolecular Oxidoreductases / Q000097:blood*; D008263:Macrophage Migration-Inhibitory Factors / Q000097:blood*; D008297:Male; D008875:Middle Aged
D008263:Macrophage Migration-Inhibitory Factors; D019746:Intramolecular Oxidoreductases; C515598:MIF protein, human