Comparison of time domain and spectral domain optical coherence tomography in measurement of macular thickness in macular edema secondary to diabetic retinopathy and retinal vein occlusion.
Purpose. To evaluate macular thickness, agreement, and intraclass repeatability in three optical coherence tomography (OCT) devices: the time domain (TD) Stratus OCT and two spectral domain (SD) OCTs, Spectralis and Cirrus SD-OCT, in eyes with macular edema secondary to diabetic retinopathy (DR) and retinal vein occlusion (VO). Methods. In a prospective observational study at a university-based retina practice, retinal thickness tomography was performed simultaneously for fifty-eight patients (91 eyes) with DR and VO employing a time domain and two spectral domain OCTs. Agreement in macular measurements was assessed by constructing Bland-Altman plots. Intraclass repeatability was assessed by intraclass correlation coefficients (ICCs). Results. Based on the Bland-Altman plots for central macular thickness, there was low agreement between the measurements of Cirrus SD-OCT and Stratus OCT, Spectralis OCT and Stratus OCT, as well as Spectralis OCT and Cirrus SD-OCT among DR and RVO patients. All three devices demonstrated high intraclass repeatability, with ICC of 98% for Stratus OCT, 97% for Cirrus SD-OCT, and 100% for Spectralis OCT among DR patients. The ICC was 97% for Stratus OCT, 79% for Cirrus SD-OCT, and 91% for Spectralis OCT among RVO patients. Conclusion. There are low agreements among interdevice measurements. However, intraclass repeatability is high in both TD and SD-OCT devices.
Retinal Imaging Research and Reading Center (RIRRC), Wilmer Eye Institute, Johns Hopkins Hospital, 600 North Wolfe Street, Maumenee 745, Baltimore, MD 21287, USA.
Elham
E
Hatef
Afsheen
A
Khwaja
Zubir
Z
Rentiya
Mohamed
M
Ibrahim
Matthew
M
Shulman
Peykan
P
Turkcuoglu
Yasir
Y
Sepah
Jianmin
J
Wang
Roomasa
R
Channa
Millena
M
Bittencourt
Abeer
A
Akhtar
Jangwon
J
Heo
Diana V
DV
Do
Quan Dong
QD
Nguyen