Outcome of expanded criteria donor kidneys that were transplanted at other Eurotransplant centers after being rejected by our institution.
OBJECTIVE
There is a growing discrepancy between the demand for renal transplants and the number of transplants conducted. For the many patients on the renal transplant waiting list, this means increased dialysis-associated morbidity, mortality and a reduced quality of life. The aim of this study was to ascertain whether it is justifiable for transplant centers to reject cadaveric donor organs on hand of marginal organ quality.


METHODS
We identified 110 kidneys that were primarily rejected for transplantation at Charité Universitätsmedizin Berlin, Campus Mitte, and later transplanted at another center within the Eurotransplant zone. Using data from the Collaborative Transplant Study, we analyzed various demographic donor data including cold ischemia times, as well as graft and recipient outcomes.


RESULTS
The median follow-up was 54 months. The cold ischemia time averaged 16 h. The organs that were primarily rejected by our center and then transplanted at other Eurotransplant centers showed 31 % of recipients had creatinine levels under 1.47 mg/dl and 94 % had levels under 2.97 mg/dl at 3-year follow-up. The mean death-censored graft survival was 71.4 months. The mean renal transplant recipient survival was 87.5 months.


CONCLUSIONS
Based on our findings, we propose that acceptance criteria for marginal donor kidneys need to be widened.
Department of Urology, Charité Universitätsmedizin Berlin, Chariteplatz 1, 10117, Berlin, Germany. frank.friedersdorff@charite.de
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F
Friedersdorff
C
C
Roller
G
G
Klein
P
P
Werthemann
H
H
Cash
K
K
Budde
T
T
Slowinski
C
C
Kempkensteffen
J
J
Busch
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Fuller
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Giessing
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002102:Cadaver; D002648:Child; D002675:Child, Preschool; D046148:Donor Selection / Q000592:standards*; D005060:Europe; D005260:Female; D005500:Follow-Up Studies; D005858:Germany; D006084:Graft Rejection / Q000453:epidemiology*; D006085:Graft Survival / Q000502:physiology*; D006801:Humans; D015994:Incidence; D007223:Infant; D007231:Infant, Newborn; D007668:Kidney / Q000502:physiology*; D016030:Kidney Transplantation / Q000401:mortality*; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D009927:Tissue and Organ Procurement / Q000592:standards*; D016896:Treatment Outcome; D055815:Young Adult