[Morphological diagnosis of connective tissue dysplasia in patients, suffering postoperative abdominal hernia].
The results of treatment of 122 patients, to whom alloplasty for postoperative abdominal hernia (POAH) was performed, were analyzed. In 76 patients a connective tissue dysplasia (CTD) was diagnosed.Determination of a various types of collagen content in connective tissue of patients, suffering CTD, may confirm or exclude this diagnosis. Diagnostic significance has the enhancement of a collagen type III content in comparison with such of a type I by three times and more. The method of lectinohistochemical investigation of connective tissue was applied as a precision-enhancing method of a CTD diagnosis. Mosaic or diffuse loss of SNA, LABA, ConA receptors of lectins by collagen fascicles, which reflect carbohydrate determinants of dense and strong collagen fascicles, made of collagen type I, witness the CTD presence. Along with this, there was observed a lectin WGA receptors expression increase, which constitutes a marker of fascicular structures, made of collagen, predominantly type III and a lectin PNA receptors, which are revealed around vessels.
S H
SH
Chetverikov
A M
AM
Iashchenko
Iu V
IuV
Ier'omin
V Iu
VIu
Vododiuk
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015415:Biomarkers / Q000032:analysis; D019411:Clinical Laboratory Techniques; D024042:Collagen Type I / Q000032:analysis; D024061:Collagen Type III / Q000032:analysis; D003238:Connective Tissue / Q000737:chemistry / Q000473:pathology*; D003240:Connective Tissue Diseases / Q000209:etiology / Q000473:pathology*; D005260:Female; D046449:Hernia, Abdominal / Q000150:complications* / Q000601:surgery*; D006801:Humans; D037102:Lectins / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications / Q000601:surgery*; D055815:Young Adult
D015415:Biomarkers; D024042:Collagen Type I; D024061:Collagen Type III; D037102:Lectins