Elongator: transcriptional or translational regulator?
The conserved multi-subunit Elongator complex was initially described as a RNA polymerase II (RNAPII) associated transcription elongation factor, but since has been shown to be involved a variety of different cellular activities. Here, we summarize recent developments in the field and discuss the resulting implications for the proposed multi-functionality of Elongator.
European Molecular Biology Laboratory, Structural and Computational Biology Unit, Heidelberg, Germany.
Sebastian
S
Glatt
Bertrand
B
Séraphin
Christoph W
CW
Müller
D000818:Animals; D051548:Histone Acetyltransferases / Q000737:chemistry / Q000235:genetics*; D006801:Humans; D047908:Intracellular Signaling Peptides and Proteins / Q000737:chemistry / Q000235:genetics; D009419:Nerve Tissue Proteins / Q000737:chemistry / Q000235:genetics; D014176:Protein Biosynthesis; D014158:Transcription, Genetic; D035602:Transcriptional Elongation Factors / Q000737:chemistry / Q000235:genetics*
D047908:Intracellular Signaling Peptides and Proteins; D009419:Nerve Tissue Proteins; D035602:Transcriptional Elongation Factors; D051548:Histone Acetyltransferases