Genomic analysis drives tailored therapy in poor risk childhood leukemia.
Ph-like acute lymphoblastic leukemia (ALL) is a novel subgroup of high-risk childhood ALL. In this issue of Cancer Cell, Roberts et al. describe the identification of genetic alterations that lead to activated kinase and cytokine receptor signaling in Ph-like ALL and demonstrate that this aberrant signaling can be inhibited effectively.
Northern Institute for Cancer Research, Newcastle University, Newcastle upon Tyne, UK. christine.harrison@newcastle.ac.uk
Christine J
CJ
Harrison
D000818:Animals; D020022:Genetic Predisposition to Disease; D006801:Humans; D009154:Mutation / Q000235:genetics*; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000201:enzymology* / Q000235:genetics*; D011505:Protein-Tyrosine Kinases / Q000235:genetics*; D018121:Receptors, Cytokine / Q000235:genetics*; D015398:Signal Transduction / Q000235:genetics*
D018121:Receptors, Cytokine; D011505:Protein-Tyrosine Kinases