Combination of isoform-selective histone/protein deacetylase inhibitors improves Foxp3+ T-regulatory cell function.
Comment on: Beier UH, et al. Sci Signal 2012; 5:ra45.
Ulf H
UH
Beier
Liqing
L
Wang
Wayne W
WW
Hancock
D000107:Acetylation / Q000187:drug effects; D000818:Animals; D051858:Forkhead Transcription Factors / Q000378:metabolism*; D017353:Gene Deletion; D006084:Graft Rejection / Q000276:immunology; D056572:Histone Deacetylase Inhibitors / Q000494:pharmacology*; D006655:Histone Deacetylases / Q000378:metabolism*; D006801:Humans; D007527:Isoenzymes / Q000037:antagonists & inhibitors / Q000378:metabolism; D018448:Models, Immunological; D056564:Sirtuin 1 / Q000378:metabolism; D050378:T-Lymphocytes, Regulatory / Q000187:drug effects / Q000201:enzymology* / Q000276:immunology*
D051858:Forkhead Transcription Factors; D056572:Histone Deacetylase Inhibitors; D007527:Isoenzymes; D056564:Sirtuin 1; D006655:Histone Deacetylases