Genetic characterization of an isolate of HIV type 1 AG recombinant form circulating in Siberia, Russia.
Before 2008, HIV-1 subtype A was the predominant genetic variant in the Novosibirsk oblast of Russia as well as in most parts of this country. However, a rapid spread of the recombinant HIV-1 02_AG form has been reported in Novosibirsk since 2009. We have analyzed the genome of the 10.RU.6637 isolate, a HIV-1 02_AG recombinant form, which represents a monophyletic cluster of the HIV-1 variants widespread in this region. Phylogenetic analysis has shown that the Siberian 10.RU.6637 isolate displays the highest sequence identity to the HIV-1 subtype AG forms circulating in Uzbekistan. However, recombination analysis of 10.RU.6637 has demonstrated that this isolate is a recombinant form between HIV-1 subtype A and CRF02_AG, differing in its genetic structure from both the CRF02_AG reference sequences and the Central Asian variants of HIV-1 02_AG.
State Research Center of Virology and Biotechnology VECTOR, Novosibirsk, Russia. baryshev_pb@vector.nsc.ru
P B
PB
Baryshev
V V
VV
Bogachev
N M
NM
Gashnikova
D000328:Adult; D001483:Base Sequence; D058872:Epidemics; D014644:Genetic Variation; D016679:Genome, Viral; D005838:Genotype; D015658:HIV Infections / Q000453:epidemiology* / Q000821:virology*; D015497:HIV-1 / Q000235:genetics*; D006801:Humans; D008297:Male; D008969:Molecular Sequence Data; D010802:Phylogeny; D016865:Reassortant Viruses / Q000235:genetics*; D012307:Risk Factors; D012800:Siberia / Q000453:epidemiology; D014610:Uzbekistan / Q000453:epidemiology