Conducting molecular biomarker discovery studies in plants.
Molecular biomarkers are molecules whose concentrations in a biological system inform about the current phenotypical state and, more importantly, may also be predictive of future phenotypic trait endpoints. The identification of biomarkers has gained much attention in targeted plant breeding since technologies have become available that measure many molecules across different levels of molecular organization and at decreasing costs. In this chapter, we outline the general strategy and workflow of conducting biomarker discovery studies. Critical aspects of study design as well as the statistical data analysis and model building will be highlighted.
Max Planck Institute for Molecular Plant Physiology, Potsdam-Golm, Germany.
Christian
C
Schudoma
Matthias
M
Steinfath
Heike
H
Sprenger
Joost T
JT
van Dongen
Dirk
D
Hincha
Ellen
E
Zuther
Peter
P
Geigenberger
Joachim
J
Kopka
Karin
K
Köhl
Dirk
D
Walther
D015415:Biomarkers / Q000378:metabolism; D001947:Breeding / Q000379:methods*; D003627:Data Interpretation, Statistical; D010944:Plants / Q000235:genetics* / Q000378:metabolism*
D015415:Biomarkers