Prediction of resting metabolic rate in critically ill patients at the extremes of body mass index.
BACKGROUND
Although estimation of energy needs by mathematical equation is common in practice, there is relatively little validation data for the equations. This is especially true at the upper and lower extremes of body size. The purpose of the current study was to provide validation data for several common equations in underweight and morbidly obese critically ill patients.


METHODS
In mechanically ventilated, critical care patients with body mass index ≤21.0 or ≥45.0 kg/m(2), indirect calorimetry was used to measure resting metabolic rate. Several equation methods were then compared with these measurements, including the Penn State equation, Faisy equation, Ireton-Jones equation, Mifflin-St Jeor equation, Harris-Benedict equation, and American College of Chest Physicians (ACCP) standard using ideal, actual, or metabolically active body weight.


RESULTS
Accuracy (percentage of estimates falling within 10% of measured) in the morbidly obese group was highest for the Penn State equation (76%) and lowest for the ACCP standard using actual body weight (0%). For the underweight group, the Penn State equation was accurate 63% of the time, but below a body mass index of 20.5, the accuracy rate dropped to 58%. No other equation was more accurate than this in the underweight patients.


CONCLUSIONS
The Penn State equation is valid in morbid obesity, but the accuracy rate is much lower in underweight critically ill patients. A modification to the equation is suggested to improve accuracy in this group.
The Pennsylvania State Milton S. Hershey Medical Center, Hershey, Pennsylvania 17033, USA. kenfield@hmc.psu.edu
David C
DC
Frankenfield
Christine M
CM
Ashcraft
Dan A
DA
Galvan
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001481:Basal Metabolism / Q000502:physiology*; D015992:Body Mass Index; D001835:Body Weight; D002153:Calorimetry, Indirect; D003422:Critical Care; D016638:Critical Illness / Q000628:therapy; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D008962:Models, Theoretical; D015596:Nutrition Assessment; D009751:Nutritional Requirements; D009767:Obesity, Morbid / Q000503:physiopathology*; D011237:Predictive Value of Tests; D015203:Reproducibility of Results; D012121:Respiration, Artificial; D013851:Thinness / Q000503:physiopathology; D055815:Young Adult