P2 receptors and immunity.
Immune cells express receptors for extracellular nucleotides named P2 receptors. P2 receptors transduce signals delivered by nucleotides present in the extracellular environment. Accruing evidence shows that purinergic signalling has a profound effect on multiple immune cell responses such as T lymphocyte proliferation, chemotaxis, cytokine release, phagocytosis, Ag presentation and cytotoxicity. This makes P2 receptors an attractive target for the therapy of immuno-mediated disease and cancer.
Institut de Biochimie et Biophysique Moléculaire et Cellulaire, CNRS UMR 8619, Université Paris Sud, 91405 Orsay Cedex, France.
Amel
A
Rayah
Jean M
JM
Kanellopoulos
Francesco
F
Di Virgilio
D000818:Animals; D006801:Humans; D058847:Inflammasomes / Q000276:immunology; D018048:Receptors, Purinergic P2 / Q000276:immunology*; D015398:Signal Transduction / Q000276:immunology
D058847:Inflammasomes; D018048:Receptors, Purinergic P2