A d-f heteronuclear complex for dual-mode phosphorescence and magnetic resonance imaging.
A d-f heteronuclear complex (Ir-Gd) by coupling an iridium(III) complex to a macrocycle-based gadolinium complex has been developed as as a dual-mode bioimaging probe for luminescence imaging and magnetic resonance imaging (MRI). The cyclometalated iridium complex showed an intense visible metal-to-ligand charge transfer (MLCT) absorption and strong yellow phosphorescent luminescence. It has specificity of staining in murine mitochondria confirmed by confocal laser scanning microscopy. The macrocycle-based gadolinium complex provides the longitudinal relaxivity of 3.36 mm(-1)s(-1) on a 3 T system, which has been applied to MRI for liver in mice. Furthermore, the biodistribution of Ir-Gd has been investigated using inductively coupled plasma-atomic emission spectroscopy (ICP-AES) analyses. Such platform should be extended to further applications in the identification and diagnosis of liver diseases.
The Key Laboratory of Resource Chemistry of Ministry of Education & Shanghai Key Laboratory of Rare Earth Functional Materials, Department of Chemistry, Shanghai Normal University, Shanghai 200234, PR China.
Hong
H
Yang
Liang
L
Ding
Lu
L
An
Zheyuan
Z
Xiang
Min
M
Chen
Jing
J
Zhou
Fuyou
F
Li
Dongmei
D
Wu
Shiping
S
Yang
D000818:Animals; D045744:Cell Line, Tumor; D002470:Cell Survival; D006801:Humans; D008163:Luminescent Measurements; D008279:Magnetic Resonance Imaging / Q000379:methods*; D051379:Mice; D018613:Microscopy, Confocal; D013054:Spectrophotometry, Atomic