Dermal delivery by niosomes of black tea extract as a sunscreen agent.
OBJECTIVE
The primary objective of this study was to investigate the feasibility of using niosomes as a delivery vehicle for the dermal administration in vitro of black tea extract (BTE) as a sunscreen.


METHODS
Multi-lamellar niosomes were obtained by means of a previously reported method of lipid hydration films. In vitro penetration experiments through nude mouse skin were carried out to evaluate the potential of niosomes as a dermal formulation. The nude mouse skin membrane allowed the effects of penetration with a niosome formulation to be evaluated. Penetration rates of caffeine- and gallic acid-loaded niosomes in a steady state were higher than dispersion in aqueous solutions.


RESULTS
For skin permeation, higher transdermal absorption rates were seen with solutions of caffeine and gallic acid.


CONCLUSIONS
In the near future, BTE as a sunscreen agent will be dermally delivered by niosomes.
School of Pharmacy, College of Pharmacy, Taipei Medical University, Taipei, Taiwan.
Meng-I
MI
Yeh
Hsiu-Chin
HC
Huang
Jia-Horng
JH
Liaw
Min-Chuan
MC
Huang
Kuei-Fen
KF
Huang
Feng-Lin
FL
Hsu
D000818:Animals; D002110:Caffeine / Q000032:analysis / Q000493:pharmacokinetics; D000697:Central Nervous System Stimulants / Q000493:pharmacokinetics; D002851:Chromatography, High Pressure Liquid; D020405:Dermis / Q000378:metabolism*; D016503:Drug Delivery Systems / Q000379:methods*; D005707:Gallic Acid / Q000032:analysis / Q000493:pharmacokinetics; D008081:Liposomes / Q000493:pharmacokinetics*; D008297:Male; D051379:Mice; D008819:Mice, Nude; D010936:Plant Extracts / Q000737:chemistry / Q000493:pharmacokinetics*; D013473:Sunscreening Agents / Q000493:pharmacokinetics*; D013662:Tea / Q000737:chemistry*; D014867:Water / Q000378:metabolism
D000697:Central Nervous System Stimulants; D008081:Liposomes; D010936:Plant Extracts; D013473:Sunscreening Agents; D013662:Tea; D014867:Water; D002110:Caffeine; D005707:Gallic Acid