Tissue surface as the reference arm in Fourier domain optical coherence tomography.
We present a simple method applicable to common-path Fourier domain optical coherence tomography (OCT) in which the tissue surface is used as the reference arm. We propose using aluminium hydroxide powder as a potential tissue surface diffuser to allow wider application of this method. This technique allows one to avoid placing a reference arm reflective element, such as glass plate, on tissue, and intrinsically avoids both coherent and complex conjugate mirror artifacts associated with glass plates. Aluminium hydroxide can be sprayed onto tissue using spray nozzles commonly found in endoscopes. The sensitivity of the tissue reference arm common-path OCT image is 94 dB for a 50-[micro sign]s charge-coupled device integration time, and 97.5 dB for a 200-[micro sign]s CCD integration time.
University of Edinburgh, School of Engineering, Institute for Integrated Micro and Nano Systems, Faraday Building, Kings Buildings, Mayfield Road, Edinburgh EH93JL, United Kingdom.
Nikola
N
Krstajić
Christian Tom A
CT
Brown
Kishan
K
Dholakia
Mario Ettore
ME
Giardini
D000536:Aluminum Hydroxide / Q000008:administration & dosage; D005583:Fourier Analysis; D006801:Humans; D007089:Image Enhancement / Q000379:methods*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D012867:Skin / Q000166:cytology*; D013499:Surface Properties; D041623:Tomography, Optical Coherence / Q000379:methods*
D000536:Aluminum Hydroxide