Use of continuous venovenous hemofiltration for acute renal failure due to multiple myeloma cast nephropathy.
Renal insufficiency is associated with high morbidity and mortality in multiple myeloma. One of the common causes for acute renal failure in multiple myeloma is cast nephropathy. It is important to reduce the levels of light chains to improve renal failure and also the overall outcome.  Plasmapheresis has failed to show any significant improvement in renal failure due to cast nephropathy as demonstrated in a recent randomized control trial. Here, we present a case series of three patients who were treated with continuous venovenous hemofiltration as a modality to remove these  free light chains. There was improvement in renal failure in these patients with decrease in the levels of free light chains. These patients remained off hemodialysis on follow-up and two of them were able to undergo hematopoietic stem cell transplantation.
Department of Medicine, Staten Island University Hospital, Staten Island, NY 10305, USA. mehtasuchita@gmail.com
Suchita
S
Mehta
Norbert
N
Shtaynberg
Michael
M
Goldman
Deepak
D
Asti
Militza
M
Kiroycheva
John
J
Pepe
D058186:Acute Kidney Injury / Q000209:etiology* / Q000628:therapy*; D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D016026:Bone Marrow Transplantation; D005260:Female; D006440:Hemofiltration; D006801:Humans; D007147:Immunoglobulin Light Chains / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged; D009101:Multiple Myeloma / Q000150:complications* / Q000628:therapy; D016896:Treatment Outcome
D007147:Immunoglobulin Light Chains