[Metabolic correction of structural changes in adrenal glands during experimental widespread purulent peritonitis].
Experiments on 55 male chinchilla rabbits with model widespread purulent peritonitis have been performed for determinig structural changes in adrenal glands with the aid of optical microscopy. The introduction of aerobic-anaerobic culture of E. Coli and B. Fragilis into the abdominal cavity causes expressed structural changes in parenchyma of adrenal glands within 6 hours. It is established for the first time that the administration of metabolic drugs citoflavin (containing succinic acid) and neoton (containing creatine phosphate) prevents the development of pathological structural changes in adrenal glands under conditions of experimental widespread purulent peritonitis.
V A
VA
Kosinets
D N
DN
Fedotov
D000311:Adrenal Glands / Q000187:drug effects* / Q000378:metabolism / Q000382:microbiology / Q000473:pathology; D000818:Animals; D001442:Bacteroides Infections / Q000188:drug therapy* / Q000378:metabolism / Q000382:microbiology; D001441:Bacteroides fragilis / Q000187:drug effects / Q000254:growth & development; D004926:Escherichia coli / Q000187:drug effects / Q000254:growth & development; D004927:Escherichia coli Infections / Q000188:drug therapy* / Q000378:metabolism / Q000382:microbiology; D007275:Injections, Intravenous; D008297:Male; D008853:Microscopy; D008867:Microtomy; D016612:Paraffin Embedding; D010538:Peritonitis / Q000188:drug therapy* / Q000378:metabolism / Q000382:microbiology; D010725:Phosphocreatine / Q000008:administration & dosage / Q000627:therapeutic use*; D011817:Rabbits; D019802:Succinic Acid / Q000008:administration & dosage / Q000627:therapeutic use*; D013492:Suppuration
D010725:Phosphocreatine; D019802:Succinic Acid