Construction of nitrogen-fused tetrahydroquinolines via a domino reaction.
An efficient domino approach for the diastereoselective synthesis of polyfunctionalized nitrogen-fused tetrahydroquinoline frameworks under mild conditions has been developed. The scope and limitation of this transformation were investigated by using a range of readily accessible enamides and benzyl azides. This method is also applicable to the formation of 2,3-functionalized enamides.
Institut de Chimie Organique et Analytique, Université d'Orléans, UMR 7311 CNRS, rue de Chartres, F-45067 Orléans Cedex 2, France.
Nicolas
N
Gigant
Isabelle
I
Gillaizeau