Alkaloids isolated from the lateral root of Aconitum carmichaelii.
Two new alkaloids, aconicarmine (1) and aconicaramide (5), were isolated from the EtOH extract of the lateral roots of Aconitum carmichaelii, together with five known compounds: fuziline (2), neoline (3), N-ethylhokbusine B (4), 5-hydroxymethylpyrrole-2-carbaldehyde (6), and oleracein E (7). Their structures were elucidated by physical and NMR analysis. Pyrrole alkaloids were isolated from A. carmichaelii for the first time. In the in vitro assays, compounds 2 and 3 showed activity against pentobarbital sodiuminduced cardiomyocytes damage by obviously recovering beating rhythm and increasing the cell viability, while compounds 5 and 7 showed moderate antibacterial activity.
State Key Laboratory Breeding Base of Systematic Research, Development and Utilization of Chinese Medicine Resources, Sichuan Province and Ministry of Science and Technology, Chengdu 610075, Sichuan, China.
Liang
L
Xiong
Cheng
C
Peng
Xiao-Fang
XF
Xie
Li
L
Guo
Cheng-Jun
CJ
He
Zhao
Z
Geng
Feng
F
Wan
Ou
O
Dai
Qin-Mei
QM
Zhou
D031841:Aconitum / Q000737:chemistry*; D000470:Alkaloids / Q000737:chemistry* / Q000302:isolation & purification* / Q000494:pharmacology; D000818:Animals; D002316:Cardiotonic Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D032383:Myocytes, Cardiac / Q000187:drug effects; D019906:Nuclear Magnetic Resonance, Biomolecular; D010424:Pentobarbital / Q000009:adverse effects; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D018517:Plant Roots / Q000737:chemistry*; D051381:Rats
D000470:Alkaloids; D002316:Cardiotonic Agents; D010936:Plant Extracts; D010424:Pentobarbital