[Investigation of the relationship between apolipoprotein gene polymorphism and hepatitis B virus infection in China].
OBJECTIVE
To explore the gene polymorphisms of ApoAI-75 Msp1, ApoB Msp1, ApoCIII Sst1, LRP5, and ApoE genotypes in two pairs of semi different modes of hepatitis B for HBV markers.


METHODS
The patients are divided into 9 groups. There were a total of 720 cases, 80 patients in each group, The patients was carried out by SnaPshot method (single-base multilocus micro-sequencing), and different genotypes of each locus were conducted by the method of sequencing in order to support the final evidence of the accuracy of test results.


RESULTS
There was association between gene polymorphisms of ApoAI-75Msp1 and ApoE and different modes of two pairs of semi-hepatitis B (P < 0.05), while there wasn't any association between gene polymorphisms of ApoB-Msp1, ApoCIII-Sst1, LRP5 and different modes of two pairs of semi-hepatitis B (P > 0.05).


CONCLUSIONS
The gene polymorphism of ApoAI-75Msp1 and ApoE was associated with the different modes of HBV markers.
Department of Laboratory Medicine, Chuiyangliu Hospital, Beijing 100022, China.
Zhi-Nong
ZN
Yin
Xin
X
Zhou
Shen-Kai
SK
Yan
Jun-Wen
JW
Wang
Qing-Ling
QL
Meng
Wei
W
Liu
D016632:Apolipoprotein A-I / Q000235:genetics; D053305:Apolipoprotein C-III / Q000235:genetics; D001053:Apolipoproteins / Q000235:genetics*; D001055:Apolipoproteins B / Q000235:genetics; D002681:China; D005838:Genotype; D006509:Hepatitis B / Q000235:genetics*; D006801:Humans; D011110:Polymorphism, Genetic
D016632:Apolipoprotein A-I; D053305:Apolipoprotein C-III; D001053:Apolipoproteins; D001055:Apolipoproteins B