Phosphine-catalyzed domino reaction: an efficient method for the synthesis of highly functionalized spirooxazolines.
A novel phosphine-catalyzed intermolecular [3 + 2] cycloaddition of ynones and N-substituted isatins was developed. In this reaction, substituted ynones, serving as a C(3) synthon, were successfully applied in intermolecular annulation reactions. A number of functionalized spirooxazolines were obtained in high yields and stereoselectivity.
State Key Laboratory and Institute of Elemento-organic Chemistry Nankai University, Tianjin 300071, People's Republic of China.
Lihua
L
Yang
Peizhong
P
Xie
Erqing
E
Li
Xin
X
Li
You
Y
Huang
Ruyu
R
Chen
D002384:Catalysis; D018360:Crystallography, X-Ray; D003500:Cyclization; D008958:Models, Molecular; D015394:Molecular Structure; D010080:Oxazoles / Q000138:chemical synthesis* / Q000737:chemistry; D010720:Phosphines / Q000737:chemistry*; D013141:Spiro Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D013237:Stereoisomerism
D010080:Oxazoles; D010720:Phosphines; D013141:Spiro Compounds; C044646:phosphine