A new soft lithographic route for the facile fabrication of hydrophilic sandwich microchips.
Manufacturing materials are an essential element for the fabrication of microfluidic chips. PDMS, the most widely used polymeric material, is associated with apparent disadvantages such as hydrophobic nature, while other materials also suffer from some limitations. In this paper, a new soft lithographic route was proposed for the facile manufacturing of hydrophilic sandwich microchips, using bisphenol A based epoxy acrylate (BABEA) as a new patterning material. The BABEA copolymers are hydrophilic, highly transparent in visible range while highly untransparent when the wavelength is less than 290 nm, and of high replication fidelity. By combining with appropriate monomers, including glycidyl methacrylate, methylmethacrylate, and acrylic acid, the copolymers contain active functional groups, which allows for easy postmodification for desirable functional units. A fabrication procedure was proposed for manufacturing hybrid quartz/BABEA copolymer/quartz microchips. In the procedure, no micromachining equipments, wet etching, or imprinting techniques were involved, making the fabrication approach applicable in ordinary chemistry laboratories. The performance of the prepared microchips was demonstrated in terms of CIEF with UV-whole channel imaging detection. The hydrophilic microchannel ensures stable focusing while the polymeric middle layer acts as a perfectly aligned optical slit for whole channel UV absorbance detection.
State Key Laboratory of Analytical Chemistry for Life Science, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing, China.
Li
L
Li
Xiaodong
X
Bi
Jianzhao
J
Yu
Carolyn L
CL
Ren
Zhen
Z
Liu
D001559:Benzhydryl Compounds; D019075:Electrophoresis, Capillary / Q000379:methods*; D004853:Epoxy Resins / Q000737:chemistry; D057927:Hydrophobic and Hydrophilic Interactions; D007525:Isoelectric Focusing / Q000379:methods*; D046210:Microfluidic Analytical Techniques / Q000295:instrumentation*; D011109:Polymethacrylic Acids / Q000737:chemistry; D013056:Spectrophotometry, Ultraviolet; D000098826:Bisphenol A Compounds
D001559:Benzhydryl Compounds; D004853:Epoxy Resins; D011109:Polymethacrylic Acids; C029420:bisphenol A epoxy resin diacrylate ester; D000098826:Bisphenol A Compounds