Short communication: effect of difructose anhydride III on serum immunoglobulin G concentration in newborn calves.
Difructose anhydride (DFA) III is an indigestible disaccharide that promotes paracellular absorption of calcium, magnesium, and other minerals in the intestine by acting on epithelial tight junctions. This study aimed to elucidate the effect of DFA III on serum IgG concentration. One hundred and twenty Holstein and Holstein/Japanese Black crossbred calves were randomly divided into 4 groups of 30 to receive untreated colostrum (DFA0) or colostrum containing 3, 6, or 18 g of DFA III (DFA3, DFA6, or DFA18, respectively). At 24 h after birth, both serum IgG (ranging from 16.4 to 21.2 mg/mL) and apparent efficiency of absorption (26.0 to 37.2%) showed increases with the amount of DFA III intake. By multiple regression analysis, the standardized partial regression coefficient for DFA III was 0.25, the second highest following that for the colostrum IgG concentration (0.80), indicating a positive effect of DFA III on serum IgG. A positive linear regression was found between colostrum IgG and serum IgG concentrations at 24h of age. These results indicate that IgG absorption occurred as a nonsaturable process, which might be characteristic of gradient-dependent paracellular transport. Thus, it was concluded that DFA III improves not only minerals but IgG absorption in calves.
Research Center, Nippon Beet Sugar Manufacturing Co. Ltd., Obihiro, Hokkaido, 080-0831, Japan.
T
T
Sato
Obihiro University of Agriculture and Veterinary Medicine, Obihiro, Hokkaido, 080-8555, Japan. Electronic address: hanada@obihiro.ac.jp.
M
M
Hanada
Research Center, Nippon Beet Sugar Manufacturing Co. Ltd., Obihiro, Hokkaido, 080-0831, Japan.
M
M
Ohtani
Research Center, Nippon Beet Sugar Manufacturing Co. Ltd., Obihiro, Hokkaido, 080-0831, Japan.
T
T
Nakai
Research Center, Nippon Beet Sugar Manufacturing Co. Ltd., Obihiro, Hokkaido, 080-0831, Japan.
M
M
Teramura
Research Center, Nippon Beet Sugar Manufacturing Co. Ltd., Obihiro, Hokkaido, 080-0831, Japan.
H
H
Sadoya
Faculty of Agriculture, Yamagata University, Tsuruoka, Yamagata, 997-8555, Japan.
T
T
Takahashi
Obihiro University of Agriculture and Veterinary Medicine, Obihiro, Hokkaido, 080-8555, Japan.
A
A
Hongo
D000818:Animals; D000831:Animals, Newborn / Q000097:blood* / Q000276:immunology; D002417:Cattle; D003126:Colostrum / Q000378:metabolism; D004187:Disaccharides / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D007074:Immunoglobulin G / Q000097:blood*; D007408:Intestinal Absorption / Q000187:drug effects
D004187:Disaccharides; D007074:Immunoglobulin G; C087758:difructose anhydride III