Influence of lung injury on cardiac output measurement using transpulmonary ultrasound dilution: a validation study in neonatal lambs.
BACKGROUND
Transpulmonary ultrasound dilution (TPUD) is a promising method for cardiac output (CO) measurement in severely ill neonates. The incidence of lung injury in this population is high, which might influence CO measurement using TPUD because of altered lung perfusion. We evaluated the influence of lung injury on the accuracy and precision of CO measurement using TPUD in an animal model.


METHODS
In nine neonatal lambs, central venous and arterial catheters were inserted and connected to the TPUD monitor. Repeated lavages with warmed isotonic saline were performed to gradually induce lung injury. CO measurements with TPUD (COtpud) were compared with those obtained by an ultrasonic transit-time flow probe around the main pulmonary artery (COufp). An increase in oxygenation index was used as an indicator of induced lung injury during the experiment. Post-mortem lung injury was confirmed by histopathological examination.


RESULTS
Fifty-five sessions of three paired CO measurements were analysed. The mean COufp was 1.53 litre min(-1) (range 0.66-2.35 litre min(-1)), and the mean COtpud was 1.65 litre min(-1) (range 0.78-2.91 litre min(-1)). The mean bias (standard deviation) between the two methods was 0.13 (0.15) litre min(-1) with limits of agreement of ±0.29 litre min(-1). The overall percentage error was 19.1%. The accuracy and precision did not change significantly during progressive lung injury. Histopathological severity scores were consistent with heterogeneous lung injury. The capability to track changes in CO using TPUD was moderate to good.


CONCLUSIONS
The accuracy and precision of CO measurement using TPUD is not influenced in the presence of heterogeneous lung injury in an animal model.
Department of Paediatrics-Neonatology, Radboud University Nijmegen Medical Centre, Internal Postal Code 804, PO Box 9101, 6500 HB Nijmegen, The Netherlands. s.vrancken@cukz.umcn.nl
S L
SL
Vrancken
W P
WP
de Boode
J C
JC
Hopman
M G
MG
Looijen-Salamon
K D
KD
Liem
A F
AF
van Heijst
D000818:Animals; D000831:Animals, Newborn; D002302:Cardiac Output; D002405:Catheterization, Central Venous / Q000295:instrumentation / Q000662:veterinary; D002406:Catheterization, Peripheral / Q000295:instrumentation / Q000662:veterinary; D004195:Disease Models, Animal; D007201:Indicator Dilution Techniques / Q000295:instrumentation / Q000662:veterinary; D055370:Lung Injury / Q000503:physiopathology / Q000662:veterinary*; D008991:Monitoring, Physiologic / Q000379:methods* / Q000662:veterinary*; D011651:Pulmonary Artery / Q000503:physiopathology; D015203:Reproducibility of Results; D034561:Sheep, Domestic; D014463:Ultrasonography / Q000295:instrumentation / Q000662:veterinary*