The intracellular Ca²⁺ channels of membrane traffic.
Regulation of organellar fusion and fission by Ca ( 2+)  has emerged as a central paradigm in intracellular membrane traffic. Originally formulated for Ca ( 2+) -driven SNARE-mediated exocytosis in the presynaptic terminals, it was later expanded to explain membrane traffic in other exocytic events within the endo-lysosomal system. The list of processes and conditions that depend on the intracellular membrane traffic includes aging, antigen and lipid processing, growth factor signaling and enzyme secretion. Characterization of the ion channels that regulate intracellular membrane fusion and fission promises novel pharmacological approaches in these processes when their function becomes aberrant. The recent identification of Ca ( 2+)  permeability through the intracellular ion channels comprising the mucolipin (TRPMLs) and the two-pore channels (TPCs) families pinpoints the candidates for the Ca ( 2+)  channel that drive intracellular membrane traffic. The present review summarizes the recent developments and the current questions relevant to this topic.
Department of Biological Sciences, University of Pittsburgh, Pittsburgh, PA, USA.
Kirill K
KK
Kiselyov
Malini
M
Ahuja
Volodymyr
V
Rybalchenko
Sandip
S
Patel
Shmuel
S
Muallem
D002118:Calcium / Q000378:metabolism; D015220:Calcium Channels / Q000378:metabolism*; D002462:Cell Membrane / Q000378:metabolism*; D005089:Exocytosis; D006801:Humans; D008247:Lysosomes / Q000378:metabolism; D050600:SNARE Proteins / Q000378:metabolism; D050051:Transient Receptor Potential Channels / Q000378:metabolism
D015220:Calcium Channels; D050600:SNARE Proteins; D050051:Transient Receptor Potential Channels; D002118:Calcium