Genetic basis of pancreas cancer development and progression: insights from whole-exome and whole-genome sequencing.
Pancreatic cancer is caused by inherited and acquired mutations in specific cancer-associated genes. The discovery of the most common genetic alterations in pancreatic cancer has provided insight into the fundamental pathways that drive the progression from a normal cell to noninvasive precursor lesions and finally to widely metastatic disease. In addition, recent genetic discoveries have created new opportunities to develop gene-based approaches for early detection, personalized treatment, and molecular classification of pancreatic neoplasms.
Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Christine A
CA
Iacobuzio-Donahue
Victor E
VE
Velculescu
Christopher L
CL
Wolfgang
Ralph H
RH
Hruban
D021441:Carcinoma, Pancreatic Ductal / Q000235:genetics / Q000473:pathology; D018450:Disease Progression; D005190:Family; D015894:Genome, Human; D018095:Germ-Line Mutation; D006801:Humans; D009361:Neoplasm Invasiveness; D009362:Neoplasm Metastasis; D010190:Pancreatic Neoplasms / Q000235:genetics* / Q000473:pathology*; D017422:Sequence Analysis, DNA