BACE inhibitory flavanones from Balanophora involucrata Hook. f.
One new flavanone (S)-5,7,3',5'-tetrahydroxy-flavanone-7-O-(6″-galloyl)-β-D-glucopyranose (1), together with one known flavanone and four known dihydrochalcones were isolated from the ethyl acetate partitions from an alcoholic extract of the whole plant of Balanophora involucrata Hook. f. All of the compounds were characterized by spectroscopic methods. Their in vitro BACE inhibitory effects were evaluated. Compounds 1, 2, 4, and 5 were found to be a little more active than the positive control, although all of which are below 50% inhibition at 10μM.
State Key Laboratory of Bioactive Substances and Functions of Natural Medicines & Ministry of Health Key Laboratory of Biosynthesis of Natural Products, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China.
Jiayi
J
Tao
Jun
J
Zhao
Ying
Y
Zhao
Yanmei
Y
Cui
Weishuo
W
Fang
D031111:Balanophoraceae / Q000737:chemistry*; D047188:Chalcones / Q000737:chemistry; D044950:Flavanones / Q000737:chemistry / Q000494:pharmacology*; D015394:Molecular Structure
C581078:(S)-5,7,3',5'-tetrahydroxy-flavanone-7-O-(6''-galloyl)-beta-D-glucopyranose; D047188:Chalcones; D044950:Flavanones