Alveolar bone grafting in association with polyostotic fibrous dysplasia and bisphosphonate-induced abnormal bone turnover in a bilateral cleft lip and palate patient: a case report.
A case is presented of extensive alveolar bone grafting in a patient with bilateral cleft lip and palate and polyostotic fibrous dysplasia. The patient previously underwent bisphosphonate therapy. Because of an abnormal and often decreased bone turnover caused by the fibrous dysplasia and the bisphosphonate therapy, bone grafting in such a patient poses several potential difficulties. In addition, the histomorphometric analysis of the bone grafts showed markedly decreased bone turnover. However, alveolar bone grafting using the iliac crest was performed successfully. Sufficient occlusion was achieved by postoperative low-loading orthodontic treatment.
Division of Oral and Maxillofacial Surgery, Niigata Graduate School of Medical and Dental Sciences, Niigata, Japan. damadama@dent.niigata-u.ac.jp
Yasumitsu
Y
Kodama
Akira
A
Ogose
Yoshimitsu
Y
Oguri
Sobhan
S
Ubaidus
Tateyuki
T
Iizuka
Ritsuo
R
Takagi
D000293:Adolescent; D000543:Alveoloplasty / Q000379:methods*; D015519:Bone Density / Q000502:physiology; D016026:Bone Marrow Transplantation / Q000379:methods; D016025:Bone Transplantation / Q000379:methods*; D001842:Bone and Bones / Q000187:drug effects* / Q000378:metabolism; D002971:Cleft Lip / Q000601:surgery*; D002972:Cleft Palate / Q000601:surgery*; D004164:Diphosphonates / Q000009:adverse effects*; D005260:Female; D005359:Fibrous Dysplasia, Polyostotic / Q000188:drug therapy / Q000601:surgery*; D005500:Follow-Up Studies; D006801:Humans; D007085:Ilium / Q000601:surgery; D008310:Malocclusion / Q000628:therapy; D020858:Tissue and Organ Harvesting / Q000379:methods; D014087:Tooth Movement Techniques / Q000379:methods; D016896:Treatment Outcome
D004164:Diphosphonates