Current concepts in tracheal reconstruction.
OBJECTIVE
Many patients require tracheal reconstruction either for tracheal stenosis/malacia or following tumor extirpation. However, such patients can be debilitated following failed conventional treatments. Recent advances in tissue engineering and vascularized composite grafts are accelerating the field of tracheal reconstruction. This article reviews new clinical concepts for tracheal reconstruction.


RESULTS
Novel treatments include composite autografts, allografts, chimeric autografts and allografts, tissue-engineered grafts, prosthetic scaffolds, and the use of free-tissue vascularized carriers.


CONCLUSIONS
New procedures for tracheal reconstruction hold much promise for treating difficult tracheal disorders and improving the quality of life for affected patients. Many of the techniques reviewed herein are single case series and require further investigation and validation.
Department of Otolaryngology, Head and Neck Surgery, University of Toronto, Toronto, Ontario, Canada.
Jason T
JT
Rich
Patrick J
PJ
Gullane
D000818:Animals; D004195:Disease Models, Animal; D058752:Free Tissue Flaps / Q000098:blood supply; D006085:Graft Survival; D006801:Humans; D008866:Microsurgery / Q000379:methods; D011183:Postoperative Complications / Q000209:etiology / Q000517:prevention & control; D011379:Prognosis; D019651:Plastic Surgery Procedures / Q000379:methods*; D013524:Surgical Flaps / Q000098:blood supply; D023822:Tissue Engineering / Q000379:methods; D054457:Tissue Scaffolds; D014132:Trachea / Q000601:surgery* / Q000637:transplantation; D014134:Tracheal Neoplasms / Q000601:surgery*; D014135:Tracheal Stenosis / Q000601:surgery*; D055090:Tracheomalacia / Q000601:surgery*; D014184:Transplantation, Homologous