Acquired hemophilia successfully treated with activated prothrombin complex concentrate and immunosuppressant combination:  a case report.
Acquired hemophilia A is a very rare but life-threatening disorder caused by autoantibody against coagulation factor VIII. The incidence was much rarer in young people. In this case report, a young woman presented with spontaneous muscle hematoma. Because of pain and limited range of motion, she underwent surgery for resolution at first. However, her symptoms and hemorrhage worsened. She was diagnosed with acquired hemophilia A. We started combination treatment with bypassing agent, activated prothrombin complex and immunosuppressants immediately and the results were successful. The acute bleeding was controlled and autoantibody was completely resolved.
Department of Internal Medicine, Ajou University Hospital, Suwon, South Korea.
Eunjung
E
Kang
Han Gyeol
HG
Kim
Joo-Ho
JH
Lee
Miyeon
M
Lee
Chang-Bum
CB
Bae
Ja Young
JY
Jeon
Mi Sun
MS
Ahn
Seong Hyun
SH
Jeong
Joon Seong
JS
Park
Seok Yun
SY
Kang
Jin-Hyuk
JH
Choi
Hyun Woo
HW
Lee
D000328:Adult; D001779:Blood Coagulation Factors / Q000627:therapeutic use*; D005260:Female; D006467:Hemophilia A / Q000175:diagnosis / Q000188:drug therapy* / Q000276:immunology; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use*
D001779:Blood Coagulation Factors; D007166:Immunosuppressive Agents; C025667:prothrombin complex concentrates