Pulsatile drug release from PLGA hollow microspheres by controlling the permeability of their walls with a magnetic field.
Pulsatile release: When a high-frequency magnetic field is applied, heat will be generated by coupling to the iron oxide nanoparticles encapsulated in the shells of PLGA hollow microspheres. As the temperature approaches the T(g)  of PLGA, the polymer chains become more mobile, subsequently increasing the free volume of PLGA matrix and significantly enhancing the diffusion of drug molecules.
Department of Chemical Engineering, National Tsing Hua University, Hsinchu, Taiwan, ROC Taiwan.
Wei-Lun
WL
Chiang
Cherng-Jyh
CJ
Ke
Zi-Xian
ZX
Liao
San-Yuan
SY
Chen
Fu-Rong
FR
Chen
Chun-Ying
CY
Tsai
Younan
Y
Xia
Hsing-Wen
HW
Sung
D000970:Antineoplastic Agents / Q000737:chemistry*; D002626:Chemistry, Pharmaceutical; D004317:Doxorubicin / Q000737:chemistry*; D004337:Drug Carriers; D005290:Ferric Compounds / Q000737:chemistry; D019344:Lactic Acid / Q000737:chemistry*; D060526:Magnetic Fields; D008863:Microspheres; D053758:Nanoparticles; D010316:Particle Size; D010539:Permeability; D011100:Polyglycolic Acid / Q000737:chemistry*; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D011673:Pulsatile Flow; D013696:Temperature
D000970:Antineoplastic Agents; D004337:Drug Carriers; D005290:Ferric Compounds; C000499:ferric oxide; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D011100:Polyglycolic Acid; D019344:Lactic Acid; D004317:Doxorubicin