C(aryl)-C(alkyl) bond formation from Cu(ClO4)2-mediated oxidative cross coupling reaction between arenes and alkyllithium reagents through structurally well-defined Ar-Cu(III) intermediates.
The stable and structurally well-defined Ar-Cu(III) intermediates, that are prepared almost quantitatively from the reaction of azacalix[1]arene[3]pyridines with Cu(ClO(4))(2)·6H(2)O under aerobic conditions, reacted smoothly with a number of alkyllithium reagents under mild conditions to form C(aryl)-C(alkyl) bonds.
Key Laboratory of Bioorganic Phosphorous Chemistry and Chemical Biology (Ministry of Education), Department of Chemistry, Tsinghua University, Beijing 100084, China.
Zu-Li
ZL
Wang
Liang
L
Zhao
Mei-Xiang
MX
Wang
D002244:Carbon / Q000737:chemistry*; D002384:Catalysis; D003300:Copper / Q000737:chemistry*; D006841:Hydrocarbons, Aromatic / Q000737:chemistry*; D007202:Indicators and Reagents / Q000737:chemistry; D008094:Lithium / Q000737:chemistry*; D008958:Models, Molecular; D008968:Molecular Conformation; D009942:Organometallic Compounds / Q000737:chemistry*; D010084:Oxidation-Reduction; D010472:Perchlorates / Q000737:chemistry*
D006841:Hydrocarbons, Aromatic; D007202:Indicators and Reagents; D009942:Organometallic Compounds; D010472:Perchlorates; C062280:copper(II) perchlorate; D002244:Carbon; D003300:Copper; D008094:Lithium