Estimating Regression Parameters in an Extended Proportional Odds Model.
The proportional odds model may serve as a useful alternative to the Cox proportional hazards model to study association between covariates and their survival functions in medical studies. In this article, we study an extended proportional odds model that incorporates the so-called "external" time-varying covariates. In the extended model, regression parameters have a direct interpretation of comparing survival functions, without specifying the baseline survival odds function. Semiparametric and maximum likelihood estimation procedures are proposed to estimate the extended model. Our methods are demonstrated by Monte-Carlo simulations, and applied to a landmark randomized clinical trial of a short course Nevirapine (NVP) for mother-to-child transmission (MTCT) of human immunodeficiency virus type-1 (HIV-1). Additional application includes analysis of the well-known Veterans Administration (VA) Lung Cancer Trial.
Full Member, Vaccine and Infectious Disease and, Fred Hutchinson Cancer Research Center, Seattle, WA 98109.
Ying Qing
YQ
Chen
Nan
N
Hu
Su-Chun
SC
Cheng
Philippa
P
Musoke
Lue Ping
LP
Zhao