[Botulism: structure and function of botulinum toxin and its clinical application].
Clostridium botulinum produces seven immunological distinct poisonous neurotoxins, A to G, with molecular masses of approximately 150kDa. In acidic foods and culture fluid, the neurotoxins associate with non-toxic components, and form large complexes designated progenitor toxins. The progenitor toxins are found in three forms named LL, L, and M. These neurotoxins and progenitor toxins were purified, and whole nucleotide sequences of their structure genes were determined. In this manuscript, the structure and function of these toxins, and the application of these toxins to clinical usage have been described.
Department of Bacteriology, Okayama University, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences.
Keiji
K
Oguma
Yumiko
Y
Yamamoto
Tomonori
T
Suzuki
Ni Nengah Dwi
NN
Fatmawati
Kumiko
K
Fujita
D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D001905:Botulinum Toxins / Q000737:chemistry* / Q000235:genetics / Q000502:physiology / Q000627:therapeutic use*; D001906:Botulism / Q000382:microbiology; D003014:Clostridium botulinum; D004421:Dystonia / Q000188:drug therapy; D006801:Humans; D014277:Trigeminal Neuralgia / Q000188:drug therapy
D001905:Botulinum Toxins