Comparison of bone regeneration between octacalcium phosphate/collagen composite and β-tricalcium phosphate in canine calvarial defect.
OBJECTIVE
The present study evaluated the efficacy of bone regeneration between synthetic octacalcium phosphate (OCP) granules combined with porcine atelocollagen (OCP/Col) and β-tricalcium phosphate (β-TCP).


METHODS
A disk of OCP/Col (20 mm diameter, 2.5 mm thick) or commercially available sintered porous β-TCP was implanted into a critical-sized calvarial defect (20 mm diameter) of adult male canines (n = 10). The newly formed bone in the defect was analyzed radiographically, crystallographically, histologically, and histomorphometrically at 6 months after implantation.


RESULTS
Histomorphometry showed that there was significantly more newly formed bone in OCP/Col-treated defects than for β-TCP (P < .05). X-Ray diffraction patterns of implanted OCP/Col were similar to those of original bone and different from those of implanted β-TCP.


CONCLUSIONS
These results suggest that OCP/Col implantation in canine critical-sized defect enhanced bone regeneration more than β-TCP, which is the most commonly used synthetic bone substitutes.
Division of Oral Surgery, Department of Oral Medicine and Surgery, Graduate School of Dentistry, Tohoku University, Sendai, Japan.
Yuji
Y
Tanuma
Keiko
K
Matsui
Tadashi
T
Kawai
Aritsune
A
Matsui
Osamu
O
Suzuki
Shinji
S
Kamakura
Seishi
S
Echigo
D000818:Animals; D001672:Biocompatible Materials / Q000494:pharmacology; D001861:Bone Regeneration / Q000187:drug effects*; D018786:Bone Substitutes / Q000494:pharmacology; D002130:Calcium Phosphates / Q000494:pharmacology*; D003094:Collagen / Q000494:pharmacology*; D004285:Dogs; D008297:Male; D008852:Microradiography; D012886:Skull / Q000000981:diagnostic imaging / Q000187:drug effects*; D014961:X-Ray Diffraction
D001672:Biocompatible Materials; D018786:Bone Substitutes; D002130:Calcium Phosphates; C059821:atelocollagen; C485817:beta-tricalcium phosphate; C022045:octacalcium phosphate; D003094:Collagen