Serum levels of IL-6, IL-10, IL-12, IL-17 and IFN-γ and their association with markers of bone metabolism in vitamin D-deficient female students.
Different studies have shown the regulatory effects of vitamin D(3) on the immune system and bone metabolism. Regarding the effects of vitamin D on immune cells and the importance of cytokines on bone metabolism, we assessed the association between serum levels of interleukin (IL)-6, IL-10, IL-12, IL-17 and IFN-γ cytokines and bone metabolism markers (Ca, P, PTH, ALP) in female students with vitamin D deficiency compared with control group. A total of 100 subjects with 25-hydroxy vitamin D(3) (25-(OH) D(3)) deficiency were selected as case and 100 subjects with sufficient 25-hydroxy vitamin D(3) (25-(OH) D(3)) were selected as the control group. The serum levels of IL-6, IL-10, IL-12, IL-17 and IFN-γ were measured by ELISA method. Ionized Ca, PTH, P, ALP levels were also determined in all participants. The results showed a statistically significant positive correlation between the levels of ALP with IFN-γ, PTH with IL-17 and a significant negative correlation between P with IL-10 in vitamin D deficient group. The results suggest that IL-17, IFN-γ and IL-10 are important mediators of bone metabolism and vitamin D affect bone metabolism, at least in part, through immune system. In addition, not only vitamin D affect bone metabolism but also modulates immune responses.
Physiology Research Center, Kerman University of Medical Sciences, Kerman, Iran.
Zahra
Z
Jamali
Mohammad Kazemi
MK
Arababadi
Gholamreza
G
Asadikaram
D000469:Alkaline Phosphatase / Q000097:blood; D015415:Biomarkers; D001842:Bone and Bones / Q000378:metabolism*; D002118:Calcium / Q000097:blood; D005260:Female; D006801:Humans; D007371:Interferon-gamma / Q000097:blood*; D016753:Interleukin-10 / Q000097:blood; D018664:Interleukin-12 / Q000097:blood; D020381:Interleukin-17 / Q000097:blood; D015850:Interleukin-6 / Q000097:blood; D007378:Interleukins / Q000097:blood*; D007492:Iran; D010012:Osteogenesis; D010281:Parathyroid Hormone / Q000097:blood; D010758:Phosphorus / Q000097:blood; D058504:Th17 Cells / Q000276:immunology / Q000378:metabolism; D014807:Vitamin D / Q000097:blood; D014808:Vitamin D Deficiency / Q000097:blood*
D015415:Biomarkers; D020381:Interleukin-17; D015850:Interleukin-6; D007378:Interleukins; D010281:Parathyroid Hormone; D016753:Interleukin-10; D014807:Vitamin D; D018664:Interleukin-12; D010758:Phosphorus; D007371:Interferon-gamma; D000469:Alkaline Phosphatase; D002118:Calcium