Effect of high vs standard early parenteral amino acid supplementation on the growth outcomes in very low birth weight infants.
BACKGROUND
The goal of this study was to evaluate the effect of 2 different strategies for parenteral amino acid (AA) supplementation in the range of standard doses (>1.0-1.5 g/kg/d) on growth outcomes in very low birth weight (VLBW) infants.


METHODS
The unit policy of AA doses on the first day of life changed from 1.5 g/kg/d (n = 56; standard protein group, SP, in 2008) to 3.0 g/kg/d (n = 53; high protein group, HP, in 2009) with a daily advance to a target dose of 3.5-4.0 g/kg/d. Daily nutritive and laboratory profiles were collected for the initial 14 days, and patient weight, height, and head circumference on postnatal day 14 and again at 36 weeks, 6 months, and 12 months of corrected age were evaluated.


RESULTS
During the first 14 days, AA intake was greater in the HP group than in the SP group (2.9 ± 0.4 vs 2.6 ± 0.4 g/kg/d, P < .001). The HP group demonstrated a lower peak plasma glucose level during the first 3 days (116 ± 24 vs 137 ± 39 mg/dL) and a higher serum urea nitrogen level for the first 14 postnatal days than the SP group (19.2 ± 7.0 vs 14.8 ± 6.7 mg/dL) (both P < .01). From birth to postnatal 14 days and to 36 weeks, 6 months, and 12 months of corrected age, the z score changes in all growth parameters did not differ between the 2 groups.


CONCLUSIONS
In the range of the standard AA protocol, there was no dose-response relationship between the early AA doses and the growth outcomes in VLBW infants.
Asan Medical Center, Department of Pediatrics, University of Ulsan College of Medicine, Seoul, Korea.
Sami
S
Yang
Byong Sop
BS
Lee
Hye-Won
HW
Park
Yong-Sung
YS
Choi
Sung-Hoon
SH
Chung
Seong-Hun
SH
Jeong
Ji-Hee
JH
Kim
Ellen Ai-Rhan
EA
Kim
Ki-Soo
KS
Kim
D000596:Amino Acids / Q000008:administration & dosage*; D001724:Birth Weight / Q000187:drug effects*; D002657:Child Development / Q000187:drug effects*; D019587:Dietary Supplements; D004305:Dose-Response Relationship, Drug; D005260:Female; D006801:Humans; D007227:Infant Nutritional Physiological Phenomena; D007231:Infant, Newborn; D007234:Infant, Premature / Q000254:growth & development; D007235:Infant, Premature, Diseases / Q000188:drug therapy; D019102:Infant, Very Low Birth Weight / Q000254:growth & development; D008297:Male; D010288:Parenteral Nutrition / Q000379:methods*
D000596:Amino Acids