C-O cross-coupling of activated aryl and heteroaryl halides with aliphatic alcohols.
A robust and general catalyst system facilitates the alkoxylation of activated heteroaryl halides with primary, secondary, and select tertiary alcohols without the need for an excess of either coupling partner. This catalyst system displays broad functional-group tolerance and excellent regioselectivity, and is insensitive to the order of reagent addition.
Department of Process Chemistry, Merck Research Laboratories, Rahway, NJ 07065, USA. peter_maligres@merck.com
Peter E
PE
Maligres
Jing
J
Li
Shane W
SW
Krska
John D
JD
Schreier
Izzat T
IT
Raheem
D000438:Alcohols / Q000737:chemistry*; D002244:Carbon / Q000737:chemistry; D002384:Catalysis; D003300:Copper / Q000737:chemistry; D006219:Halogens / Q000737:chemistry*; D006571:Heterocyclic Compounds / Q000737:chemistry*; D010100:Oxygen / Q000737:chemistry; D010165:Palladium / Q000737:chemistry; D013237:Stereoisomerism
D000438:Alcohols; D006219:Halogens; D006571:Heterocyclic Compounds; D010165:Palladium; D002244:Carbon; D003300:Copper; D010100:Oxygen