The power of negative thinking: which cells limit tumor immunity?
Why human tumors grow infiltrated by specific antitumor T cells has been a mystery attributed to negative factors released directly by the tumor or indirectly through immune intermediaries. The frequency and phenotype of myeloid-derived suppressor cells in the peripheral blood of melanoma patients and healthy donors are surprisingly similar.
Department of Surgery, University of Pittsburgh Cancer Institute, Pittsburgh, PA, USA.
Siuwah
S
Tang
Michael T
MT
Lotze
D000818:Animals; D005260:Female; D006801:Humans; D008297:Male; D008545:Melanoma; D022423:Myeloid Cells; D012878:Skin Neoplasms; D013601:T-Lymphocytes