Copper-catalyzed conversion of aryl and heteroaryl bromides into the corresponding chlorides.
An efficient method for the synthesis of aryl and heteroaryl chlorides is described. The reactions of aryl and heteroaryl bromides with tetramethylammonium chloride proceeded smoothly in the presence of a copper catalyst under mild reaction conditions to produce the corresponding chlorides in satisfactory to excellent yields.
State Key Laboratory of Fine Chemicals, Dalian University of Technology, Dalian 116023, China. fengxiujuan@dlut.edu.cn
Xiujuan
X
Feng
Yiping
Y
Qu
Yanlei
Y
Han
Xiaoqiang
X
Yu
Ming
M
Bao
Yoshinori
Y
Yamamoto