An appeal for the presentation of detailed human derived data for dose-response calculations in nutritional science.
If a diet, food or food constituent is recognised to have both health benefits and health risks, the benefits have to be compared with the risks to develop coherent scientific evidence-based dietary advice. This means that both risk and benefit assessment should follow a similar paradigm and that benefits and risks are expressed in a common currency. Dose-response functions are vital for that purpose. However, the construction of these functions is often of second interest in the currently available (epidemiological) literature. In order to bring forward the potential of epidemiological studies for the construction of the dose-response functions for benefit-risk purposes, the scientific (nutrition and health) community is asked to expand on their data presentation, either by presenting more detailed data focusing on dose-response necessities, and/or by sharing primary data.
National Institute for Public Health and The Environment, Bilthoven, The Netherlands.
Nynke
N
de Jong
Janneke
J
Verkaik-Kloosterman
Hans
H
Verhagen
Hendriek C
HC
Boshuizen
Bas
B
Bokkers
Jeljer
J
Hoekstra
D004305:Dose-Response Relationship, Drug; D006801:Humans; D052756:Nutritional Sciences; D018570:Risk Assessment