Quality of life in patients with head and neck cancer receiving targeted or multimodal therapy--update of the EORTC QLQ-H&N35, Phase I.
BACKGROUND
The objective of this study was to identify relevant quality of life (QOL) issues in patients with head and neck cancer receiving multimodal and/or targeted therapies.


METHODS
The literature was searched for QOL issues reported after multimodal and/or targeted therapies resulting in a list of potentially relevant issues. These were discussed within a multiprofessional expert group, revised, and subsequently rated for relevance by patients and health care providers.


RESULTS
Twenty-seven issues were extracted that are not covered by the current version of the European Organization for Research and Treatment of Cancer (EORTC) questionnaires. Interviews (96 health care providers from 13 countries, 137 patients from 8 countries) revealed that 26 of these issues were relevant for patients with head and neck cancer.


CONCLUSIONS
Studies investigating targeted and/or multimodal therapy should consider that some QOL issues specific to these treatments are not covered by the current version of the EORTC instruments. Consequently, the EORTC head and neck cancer module is currently in revision.
Department of Medical Psychology and Medical Sociology, University of Leipzig, Leipzig, Germany. susanne.singer@medizin.uni-leipzig.de
Susanne
S
Singer
Juan I
JI
Arraras
Ingo
I
Baumann
Andreas
A
Boehm
Wei-Chu
WC
Chie
Razvan
R
Galalae
Johannes A
JA
Langendijk
Orlando
O
Guntinas-Lichius
Eva
E
Hammerlid
Monica
M
Pinto
Ourania
O
Nicolatou-Galitis
Claudia
C
Schmalz
Mehmet
M
Sen
Allen C
AC
Sherman
Karin
K
Spiegel
Irma
I
Verdonck-de Leeuw
Noam
N
Yarom
Paola
P
Zotti
Dirk
D
Hofmeister
D000368:Aged; D003131:Combined Modality Therapy; D005260:Female; D006258:Head and Neck Neoplasms / Q000523:psychology* / Q000628:therapy; D006801:Humans; D008297:Male; D008875:Middle Aged; D058990:Molecular Targeted Therapy; D011788:Quality of Life / Q000523:psychology; D011795:Surveys and Questionnaires; D016896:Treatment Outcome