Comparison of serum tumor associated material (TAM) with conventional biomarkers in cancer patients.
OBJECTIVE
To compare expression level of serum tumor associated materials (TAM) with several conventional serum tumor biomarkers, eg., carcinoembryonic antigen (CEA), carbohydrate antigen19-9 (CA19-9), carbohydrate antigen 15-3 (CA15-3), alpha-fetoprotein(AFP), in selected solid tumors.


METHODS
Patients diagnosed histologically or cytologically with liver, breast, esophageal, gastric, colorectal or pancreatic cancers were enrolled into this study. After diagnosis, the level of TAM was determined by chemical colorimetry, and levels of conventional tumor markers was measured by chemiluminescence methods.


RESULTS
A total of 560 patients were enrolled into this study. No statistically significant difference was detected in TAM and the above mentioned tumor biomarkers in terms of their positivity and negativity (P>0.05).


CONCLUSIONS
Detection of TAM in liver, breast, esophageal, gastric, colorectal, and pancreatic cancer patients demonstrates a good accordance with CEA, CA199, CA153, and AFP, thus suggesting that further study is warranted to verify whether TAM could be a surrogate for these conventional biomarkers.
Department of Chemotherapy, Jiangsu Cancer Hospital, Nanjing, China.
Jian
J
Shu
Cheng-Guang
CG
Li
Yang-Chen
YC
Liu
Xiao-Chun
XC
Yan
Xu
X
Xu
Xin-En
XE
Huang
Jie
J
Cao
Ying
Y
Li
Yan-Yan
YY
Lu
Xue-Yan
XY
Wu
Jin
J
Liu
Jin
J
Xiang
D014408:Biomarkers, Tumor / Q000097:blood*; D018395:CA-19-9 Antigen / Q000097:blood; D002272:Carcinoembryonic Antigen / Q000097:blood; D005260:Female; D006017:Glycolipids / Q000097:blood*; D006023:Glycoproteins / Q000097:blood*; D006801:Humans; D008297:Male; D008875:Middle Aged; D018396:Mucin-1 / Q000097:blood; D009367:Neoplasm Staging; D009369:Neoplasms / Q000175:diagnosis* / Q000378:metabolism*; D011379:Prognosis; D000509:alpha-Fetoproteins / Q000378:metabolism
D014408:Biomarkers, Tumor; D018395:CA-19-9 Antigen; D002272:Carcinoembryonic Antigen; D006017:Glycolipids; D006023:Glycoproteins; D018396:Mucin-1; D000509:alpha-Fetoproteins