Novel serotypes 105 and 116 are members of distinct subgroups of human enterovirus C.
The full coding sequences of two novel human enterovirus (HEV)-C serotypes 105 and 116, sampled in the Republic of the Congo in 2010 and in Russia in 2011, were identified in this study. Enterovirus (EV)-105 was closest to EV-104 in the 5' NTR and to EV-109 in the coding genome region. It had the same unconventional 5' NTR as EV-104 and EV-109. The non-cytopathogenic EV-116 was phylogenetically close to coxsackievirus (CV)-A1, CV-A19 and CV-A22, which also cannot be propagated in routinely used cell cultures. There were signs of recombination within this subgroup of HEV-C; however, recombination with conventional HEV-C was restricted, implying partial reproductive isolation. As there is also evidence of different permissive replication systems and distinct genetic properties of these subgroups, they may represent subspecies of the HEV-C species or different stages of speciation.
Chumakov Institute of Poliomyelitis and Viral Encephalitides, Moscow, Russia.
Alexander N
AN
Lukashev
Institute of Virology, University of Bonn Medical Centre, Bonn, Germany.
Jan Felix
JF
Drexler
Khabarovsk Institute of Epidemiology and Microbiology, Khabarovsk, Russia.
Valeria O
VO
Kotova
Khabarovsk Institute of Epidemiology and Microbiology, Khabarovsk, Russia.
Elena N
EN
Amjaga
Center of Hygiene and Epidemiology in Khabarovsk Region, Khabarovsk, Russia.
Vadim I
VI
Reznik
Chumakov Institute of Poliomyelitis and Viral Encephalitides, Moscow, Russia.
Anatoly P
AP
Gmyl
Centre International de Recherches Médicales de Franceville (CIRMF), Franceville, Gabon.
Gilda
G
Grard
Centre International de Recherches Médicales de Franceville (CIRMF), Franceville, Gabon.
Raphael
R
Taty Taty
Khabarovsk Institute of Epidemiology and Microbiology, Khabarovsk, Russia.
Olga E
OE
Trotsenko
Centre International de Recherches Médicales de Franceville (CIRMF), Franceville, Gabon.
Eric M
EM
Leroy
Institute of Virology, University of Bonn Medical Centre, Bonn, Germany.
Christian
C
Drosten
D003223:Congo / Q000453:epidemiology; D030015:Enterovirus C, Human / Q000145:classification* / Q000235:genetics*; D004769:Enterovirus Infections / Q000453:epidemiology / Q000821:virology; D014644:Genetic Variation; D006801:Humans; D010802:Phylogeny; D012367:RNA, Viral / Q000235:genetics; D016865:Reassortant Viruses; D012426:Russia / Q000453:epidemiology; D012703:Serotyping; D014779:Virus Replication
D012367:RNA, Viral