[Effect of a combination of glutamyl-tryptophan and glycyrrhizic acid on the course of acute infection caused by influenza (H3H2) virus in mice].
The purpose of the study was to evaluate the modulating effect of glutamyl-tryptophan (EW), glycyrrhizic acid (GA), and their combination on the course of experimental infection caused by influenza A (H3N2) virus in mice. The animals were infected with influenza A/Aichi/2/68 (H3N2) virus in a dose of 1 or 10 LD50. GA (10 mg/kg body weight) and EW (0.1, 10, and 1000 microg/kg) alone or in combination were intraperitoneally injected for 5 days, starting on day 1 of virus infection. Rimantadine 50 mg/kg/day was used as a comparison drug. The combination of EW (1000 microg/kg) and GA (10 mg/kg) was ascertained to exert the maximum protective effect manifesting itself in reducing the death of infected animals (by 75-79% compared to the control depending on the viral dose) and the titers of viruses accumulated in the lung (5-6 log EID50) and in preventing lung tissue edema and inflammation. The noted effect was comparable with that seen in the use of rimantadine. The agents used alone had a lower efficacy than rimantadine. The findings permit the combination of GA and EW to be considered to be a promising agent for the treatment of influenza.
V S
VS
Smirnov
V V
VV
Zarubaev
P M
PM
Anfimov
A A
AA
Shtro
D000818:Animals; D004151:Dipeptides / Q000008:administration & dosage*; D004338:Drug Combinations; D019695:Glycyrrhizic Acid / Q000008:administration & dosage*; D053122:Influenza A Virus, H3N2 Subtype / Q000187:drug effects* / Q000472:pathogenicity; D008168:Lung / Q000473:pathology; D051379:Mice; D009976:Orthomyxoviridae Infections / Q000188:drug therapy* / Q000821:virology; D012299:Rimantadine / Q000008:administration & dosage; D014779:Virus Replication / Q000187:drug effects
D004151:Dipeptides; D004338:Drug Combinations; D012299:Rimantadine; C057081:alpha-glutamyltryptophan; D019695:Glycyrrhizic Acid