Chemical constituents, anti-inflammatory and antioxidant activities of bark extracts from Prunus tucumanensis Lillo.
The anti-inflammatory, antioxidant, antimicrobial and cytotoxic activities of the hexane (HE), chloroform (CE) and methanol (ME) extracts obtained from the bark of Prunus tucumanensis Lillo were investigated. Both ME and CE extracts displayed a significant in vitro anti-inflammatory activity similar to dexamethasone and to a commercial formulation (Pygeum) used for the treatment of benign prostatic hyperplasia (BPH). ME exhibited powerful antioxidant (67.6% relative to BHT) and free radical scavenging (RC50 = 5 ppm) activities, antimicrobial activities against Staphylococcus aureus and Mycobacterium smegmatis and did not show any cytotoxic effect on human-derived macrophage cells. Chemical analyses showed that (2 R,3 R)-3,5,7,3',5'-pentahydroxyflavan, β-sitosterol and β-sitosterol-3-O-β-D-glucopyranoside (daucosterol) are relevant components of ME.
Facultad de Bioquímica Química y Farmacia, INQUINOA-CONICET, Instituto de Química Orgánica, Universidad Nacional de Tucumán, S. M. de Tucumán T4000INI, Argentina.
Sandra M
SM
Bach
Marina E
ME
Perotti
Ana P
AP
Merep
Guillermo E
GE
Marcial
Alfredo
A
Grau
Rodgoun
R
Attarian
Yossef
Y
Av-Gay
Horacio
H
Bach
César A N
CA
Catalán
D000890:Anti-Infective Agents / Q000737:chemistry* / Q000494:pharmacology*; D000893:Anti-Inflammatory Agents / Q000737:chemistry* / Q000494:pharmacology*; D000975:Antioxidants / Q000737:chemistry* / Q000494:pharmacology*; D001713:Biphenyl Compounds / Q000737:chemistry; D006801:Humans; D008826:Microbial Sensitivity Tests; D010851:Picrates / Q000737:chemistry; D024301:Plant Bark / Q000737:chemistry*; D027861:Prunus / Q000737:chemistry*; D013211:Staphylococcus aureus / Q000187:drug effects
D000890:Anti-Infective Agents; D000893:Anti-Inflammatory Agents; D000975:Antioxidants; D001713:Biphenyl Compounds; D010851:Picrates; C004931:1,1-diphenyl-2-picrylhydrazyl