The effects of adjuvant immunoglobulin M-enriched immunoglobulin therapy on mortality rate and renal function in sepsis-induced multiple organ dysfunction syndrome: retrospective analysis of intensive care unit patients.
OBJECTIVE
To determine the effect of immunoglobulin (Ig)M-enriched Ig therapy on mortality rate and renal function in sepsis-induced multiple organ dysfunction syndrome (MODS), using the Acute Physiology and Chronic Health Evaluation II (APACHE II) score.


METHODS
Retrospective study  of patients with sepsis-induced MODS treated with standard antibiotic plus supportive therapy (control group) or IgM-enriched Ig therapy adjuvant to control group therapy (IVIg group). Total length of stay in the intensive care unit (ICU), overall mortality rate and 28-day case fatality rate  (CFR), as well as APACHE II scores and renal function parameters at day 1 and day 4 of therapy, were recorded.


RESULTS
A total of 118 patients were included (control group, n = 62; IVIg group, n = 56). In both groups, day 4 APACHE II scores decreased significantly compared with  day 1 scores; the effect of treatment on renal function was minimal. Length of ICU stay, overall mortality rate and 28-day CFR were significantly lower in the IVIg group compared with the control group.


CONCLUSIONS
Adding IgM-enriched Ig therapy to standard therapy for MODS improved general  clinical conditions and significantly reduced APACHE II scores, overall mortality rate and 28-day CFR, although effects on renal function were minimal.
Department of Anaesthesiology and Reanimation, Faculty of Medicine, Süleyman Demirel University, Isparta, Turkey. lutfiyavuz@gmail.com
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D018806:APACHE; D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006801:Humans; D007075:Immunoglobulin M / Q000627:therapeutic use*; D007362:Intensive Care Units; D007677:Kidney Function Tests; D008297:Male; D008875:Middle Aged; D009102:Multiple Organ Failure / Q000401:mortality* / Q000503:physiopathology; D012189:Retrospective Studies; D018805:Sepsis / Q000188:drug therapy* / Q000401:mortality / Q000503:physiopathology; D014421:Turkey; D055815:Young Adult
D007075:Immunoglobulin M