Relative configuration of JBIR-129, a cytotoxic 34-membered glycosidic polyol macrolide from Streptomyces sp. RK74.
JBIR-129 was isolated as the potent cytotoxic compound, which consists of the 34-membered polyol macrolide skeleton with five sugar moieties. The relative configuration of the aglycone moiety (C7-C27 and C33-C39) was established by the J-based configuration analysis using vicinal (1)H-(1)H (from (1)H NMR and PS-DQF-COSY spectra) and long-range (1)H-(13)C coupling constants (from sge-HETLOC and several J-resolved HMBC spectra) with steric information obtained from ROESY.
Japan Biological Informatics Consortium (JBIC), 2-4-7 Aomi, Tokyo 135-0064, Japan.
Teppei
T
Kawahara
Miho
M
Izumikawa
Motoki
M
Takagi
Kazuo
K
Shin-ya
D000900:Anti-Bacterial Agents; D018942:Macrolides / Q000737:chemistry* / Q000494:pharmacology*; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D013237:Stereoisomerism; D013302:Streptomyces / Q000737:chemistry*
D000900:Anti-Bacterial Agents; C577727:JBIR-129; D018942:Macrolides