Exercise recommendations for childhood cancer survivors exposed to cardiotoxic therapies: an institutional clinical practice initiative.
Childhood cancer survivors who have received treatment with anthracyclines are at risk for developing cardiomyopathy in dose-dependent fashion. Historically, restrictions on certain types of physical activity that were intended to preserve cardiac function have been recommended, based on a mixture of evidence-based and consensus-based recommendations. In the LIFE Cancer Survivorship & Transition Program at Children's Hospital Los Angeles, the authors reevaluated their recommendations for exercise in survivors who were exposed to anthracyclines, with or without irradiation in proximity to the myocardium. The primary goal was to develop consistent, specific, practical, safe, and (where possible) evidence-based recommendations for at-risk survivors in the program. To accomplish this, the authors referred to current exercise guidelines for childhood cancer survivors, consulted recent literature for relevant populations, and obtained input from the program's pediatric cardiology consultant. The resulting risk-based exercise recommendations are designed to complement current published guidelines, maximize safe exercise, and help childhood cancer survivors return to a normal life that emphasizes overall wellness and physical activity. This article describes a single institution's experience in modifying exercise recommendations for at-risk childhood survivors and includes the methods, findings, and current institutional practice recommendations along with sample education materials.
Children's Hospital Los Angeles, CA 90027, USA. mokada@chla.usc.edu
Maki
M
Okada
Kathleen A
KA
Meeske
Jondavid
J
Menteer
David R
DR
Freyer
D018943:Anthracyclines / Q000009:adverse effects / Q000627:therapeutic use; D000903:Antibiotics, Antineoplastic / Q000009:adverse effects / Q000627:therapeutic use; D009202:Cardiomyopathies / Q000139:chemically induced / Q000209:etiology*; D002648:Child; D003131:Combined Modality Therapy / Q000009:adverse effects*; D019317:Evidence-Based Medicine; D015444:Exercise; D005500:Follow-Up Studies; D006321:Heart / Q000528:radiation effects*; D006801:Humans; D009369:Neoplasms / Q000188:drug therapy / Q000532:radiotherapy / Q000534:rehabilitation*; D017410:Practice Guidelines as Topic; D018570:Risk Assessment; D017741:Survivors; D016896:Treatment Outcome
D018943:Anthracyclines; D000903:Antibiotics, Antineoplastic