The bioassay-guided isolation of growth inhibitors of adult T-cell leukemia (ATL), from the Jamaican plant Hyptis verticillata, and NMR characterization of hyptoside.
Through bioassay-guided isolation, five compounds with growth inhibitory activity on S1T, an adult T-cell leukemia (ATL) cell line, were isolated from the crude methanol extract of the aerial parts of Hyptis verticillata.
Graduate School of Science and Engineering, Kagoshima University, 1-21-35 Korimoto, Kagoshima 890-0065, Japan. thamada@sci.kagoshima-u.ac.jp
Toshiyuki
T
Hamada
Yohann
Y
White
Mitsuyoshi
M
Nakashima
Yusuke
Y
Oiso
Masaki J
MJ
Fijita
Hiroaki
H
Okamura
Tetsuo
T
Iwagawa
Naomichi
N
Arima
D000970:Antineoplastic Agents / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D017209:Apoptosis / Q000187:drug effects; D045744:Cell Line, Tumor; D004354:Drug Screening Assays, Antitumor; D006131:Growth Inhibitors / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D006801:Humans; D031331:Hyptis / Q000737:chemistry*; D020128:Inhibitory Concentration 50; D015459:Leukemia-Lymphoma, Adult T-Cell; D019906:Nuclear Magnetic Resonance, Biomolecular; D035261:Plant Components, Aerial / Q000737:chemistry; D010936:Plant Extracts / Q000737:chemistry*
D000970:Antineoplastic Agents; D006131:Growth Inhibitors; D010936:Plant Extracts