[Adenocarcinoma of the prostate in patients under 50 years of age: analysis of 10 cases].
OBJECTIVE
To analyze the clinicopathologic features of 10 Chinese prostate adenocarcinoma patients under 50 years.


METHODS
Between January  2007 and April 2012, 10 cases of prostate adenocarcinoma patients under 50 years (age: 36-49) were diagnosed at our institution through prostate biopsy.  The indications of biopsy were abnormal digital rectal examination (7 cases) and/or a total prostate specific antigen (PSA) over 4.0 μg/L (4 cases). The  clinicopathological data of these patients were reviewed. The results of biopsy were 1 case with Gleason score (GS) 6, 4 cases with GS 7 and 5 cases with  GS 9. In the study, 7 patients were diagnosed with cT4. Lymph node metastasis and bone metastasis were found in 5 and 4 cases, respectively. The  treatments were hormonal therapy in 5 cases, radical prostatectomy in 2 cases and combination therapy in 3 cases.


RESULTS
During the follow-up, 6  patients were in progression within 3 to 7 months, 1 patient died after 3 years, and 4 patients were lost of the follow-up.


CONCLUSIONS
These findings  suggest that the Chinese prostate adenocarcinoma patients with age under 50 years are likely to have more aggressive tumor and combination therapy  might be appropriate.
Department of Urology, Air Force General Hospital of PLA, Beijing, China.
Da-wei
DW
Mu
Zhi-song
ZS
He
Wei
W
Yu
Yi
Y
Song
Xue-song
XS
Li
Li-qun
LQ
Zhou
Jie
J
Jin
Shu-qing
SQ
Li
Gang-zhi
GZ
Shan
Xin-yu
XY
Yang
Qun
Q
He
D000230:Adenocarcinoma / Q000473:pathology / Q000601:surgery*; D000328:Adult; D000367:Age Factors; D018931:Antineoplastic Agents, Hormonal / Q000627:therapeutic use*; D001707:Biopsy, Needle; D003131:Combined Modality Therapy; D006801:Humans; D008297:Male; D008875:Middle Aged; D009362:Neoplasm Metastasis; D011379:Prognosis; D011468:Prostatectomy / Q000379:methods*; D011471:Prostatic Neoplasms / Q000473:pathology / Q000601:surgery*
D018931:Antineoplastic Agents, Hormonal