New antiplasmodial bromotyrosine derivatives from Suberea ianthelliformis Lendenfeld, 1888.
Four samples of Suberea ianthelliformis were investigated and furnished five new and 13 known brominated tyrosine-derived compounds. Two of the new compounds were identified as araplysillin N20-formamide and its N-oxide derivative. Three other new compounds, araplysillins IV, V, and VI, were isolated and identified as analogs of araplysillin II. Most of these compounds exhibit moderate inhibitory activities against chloroquine-resistant and -sensitive strains of Plasmodium falciparum, and were investigated for their PFTase inhibitory properties. The chemical content of the investigated sponges is correlated with their molecular phylogeny.
UMR 152, IRD, 118, route de Narbonne, FR-31062 Toulouse cedex 9, France.
Luke
L
Mani
Valerie
V
Jullian
Beatrice
B
Mourkazel
Alexis
A
Valentin
Joëlle
J
Dubois
Thierry
T
Cresteil
Eric
E
Folcher
John N A
JN
Hooper
Dirk
D
Erpenbeck
William
W
Aalbersberg
Cécile
C
Debitus
D000818:Animals; D000962:Antimalarials / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D001483:Base Sequence; D006801:Humans; D016778:Malaria, Falciparum / Q000188:drug therapy; D008969:Molecular Sequence Data; D010963:Plasmodium falciparum / Q000187:drug effects*; D011161:Porifera / Q000737:chemistry*; D014443:Tyrosine / Q000031:analogs & derivatives* / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology
D000962:Antimalarials; C475724:bromotyrosine; D014443:Tyrosine