Orthostatic hypotension, non-dipping and striatal dopamine in Parkinson disease.
Orthostatic hypotension and non-dipping are relatively common autonomic dysfunctions in patients with Parkinson disease (PD). These abnormalities have been thought to occur independently of striatal dopaminergic depletion; however, only little preliminary information is available. In this study, we investigated the association of neurocirculatory changes with striatal dopamine transporter status in 69 patients with early PD. Seventeen patients had orthostatic hypotension and 55 patients were non-dippers. A comparison between cases with and without orthostatic hypotension was insignificant for striatal dopamine transporter uptake. These insignificances continued in a comparison of dippers and non-dippers. These results suggest that sympathetic noradrenergic dysfunctions in PD are independent of striatal dopamine transporter depletion.
Department of Neurology, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.
Yoon-Sang
YS
Oh
Joong-Seok
JS
Kim
Yong-An
YA
Chung
Ie Ryung
IeR
You
Dong-Won
DW
Yang
Sung-Woo
SW
Chung
Jeong-Wook
JW
Park
Yeong-In
YI
Kim
Kwang-Soo
KS
Lee
D000368:Aged; D001794:Blood Pressure / Q000502:physiology; D016009:Chi-Square Distribution; D003342:Corpus Striatum / Q000000981:diagnostic imaging / Q000378:metabolism*; D004298:Dopamine / Q000378:metabolism*; D005260:Female; D019416:Head Movements / Q000502:physiology*; D006801:Humans; D007024:Hypotension, Orthostatic / Q000175:diagnosis / Q000000981:diagnostic imaging / Q000209:etiology*; D008297:Male; D008875:Middle Aged; D010300:Parkinson Disease / Q000150:complications* / Q000000981:diagnostic imaging / Q000473:pathology*; D049268:Positron-Emission Tomography; D018667:Tilt-Table Test; D014057:Tomography, X-Ray Computed; D014326:Tropanes
D014326:Tropanes; C087552:2-carbomethoxy-8-(3-fluoropropyl)-3-(4-iodophenyl)tropane; D004298:Dopamine