A novel method for the determination of isokinetic ratios and its application in the synthesis of two new positional scanning libraries.
A novel method for the direct evaluation of the equimolarity of the compounds contained in a mixture is presented. We applied the method toward calculating isokinetic ratios for the reaction between the amine termini of a resin bound peptide fragment and a sulfonyl chloride to produce equal molar mixtures of sulfonamides. The results of this study and the application of the method to the synthesis of two new positional scanning synthetic combinatorial libraries (PS-SCL) are discussed.
Torrey Pines Institute for Molecular Studies , 11350 SW Village Parkway, Port St. Lucie, Florida 34987, United States.
Marc A
MA
Giulianotti
Ginamarie
G
Debevec
Radleigh G
RG
Santos
Laura E
LE
Maida
Wenteng
W
Chen
Lili
L
Ou
Yongping
Y
Yu
Colette T
CT
Dooley
Richard A
RA
Houghten
D020650:Combinatorial Chemistry Techniques / Q000379:methods*; D010446:Peptide Fragments / Q000737:chemistry; D010879:Piperazines / Q000138:chemical synthesis / Q000737:chemistry; D054852:Small Molecule Libraries / Q000138:chemical synthesis* / Q000737:chemistry; D013449:Sulfonamides / Q000138:chemical synthesis* / Q000737:chemistry
D010446:Peptide Fragments; D010879:Piperazines; D054852:Small Molecule Libraries; D013449:Sulfonamides