Accuracy of frozen sections for intraoperative diagnosis of complex atypical endometrial hyperplasia.
OBJECTIVE
The purpose of this study was to correlate the histological diagnosis made during intraoperative frozen section (FS) examination of hysterectomy samples with complex atypical endometrial hyperplasia (CAEH) diagnosed with definitive paraffin block histology.


METHODS
FS pathology results of 125 patients with a pre- operative biopsy showing CAEH were compared retrospectively with paraffin block pathology findings.


RESULTS
Paraffin block results were consistent with FS in 78 of 125 patients (62.4%). The FS sensitivity and specificity of detecting cancer were 81.1% and 97.9%, with negative and positive predictive values of 76.7%, and 98.4%, respectively. Paraffin block results were reported as endometrial cancer in 77 of 125 (61.6%) patients. Final pathology was endometrial cancer in 45.3% patients diagnosed at our center and 76.9% for patients who had their diagnosis at other clinics (p=0.018). Paraffin block results were consistent with FS in 62.4% of all cases Consistence was 98.4% in patients who had endometrial cancer in FS.


CONCLUSIONS
FS does not exclude the possibility of endometrial cancer in patients with the preoperative diagnosis of CAEH. In addition, sufficient endometrial sampling is important for an accurate diagnosis.
Gynecologic Oncology Division, Etlik Zubeyde Hanim Women's Health Research and Teaching Hospital, Ankara, Turkey. turantaner@yahoo.com
Taner
T
Turan
Burak
B
Karadag
Emine
E
Karabuk
Gokhan
G
Tulunay
Nejat
N
Ozgul
Murat
M
Gultekin
Nurettin
N
Boran
Zuhal
Z
Isikdogan
Mehmet Faruk
MF
Kose
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D004714:Endometrial Hyperplasia / Q000175:diagnosis* / Q000601:surgery*; D016889:Endometrial Neoplasms / Q000175:diagnosis* / Q000601:surgery*; D005260:Female; D005629:Frozen Sections; D006801:Humans; D008875:Middle Aged; D016343:Monitoring, Intraoperative; D009215:Myometrium / Q000473:pathology / Q000601:surgery; D009361:Neoplasm Invasiveness; D009367:Neoplasm Staging; D011379:Prognosis; D012189:Retrospective Studies; D012680:Sensitivity and Specificity