Tissue Doppler and myocardial deformation imaging to detect myocardial dysfunction in pediatric cancer patients treated with high doses of anthracyclines.
OBJECTIVE
To detect subtle changes in myocardial function in pediatric cancer patients treated with high dose anthracyclines.


METHODS
In all, 19 pediatric cancer patients with no cardiotoxicity findings treated with a cumulative anthracycline dose of ≥350 mg/m(2)  and healthy participants of the same age were included in the study. Transthoracic echocardiography measurements, pulsed-wave tissue Doppler from the basal portions of all walls and strain and strain rate imaging of all walls from basal portion were obtained.


RESULTS
A total of 19 patients (13 boys and six girls) and 17 participants (10 boys and seven girls) in the control group were enrolled. Three patients had subnormal ejection fraction (EF) and fractional shortening (FS) values. There was no significant difference in EF and FS between the two groups. The left ventricle isovolumic relaxation time was prolonged (P = 0.02) and the mitral color propagation velocity was decreased in patients (P = 0.001). Peak systolic strain and strain rates of the right ventricle, septal, lateral and inferior wall basal region of the left ventricle were significantly lower in patients than controls (all P < 0.05). Tissue Doppler measurements of early and late diastolic myocardial velocities of the right ventricular free wall, lateral wall of left ventricle and septum, and peak systolic myocardial velocity of the left ventricle anterior wall were significantly lower in patients (all P < 0.05).


CONCLUSIONS
Myocardial Doppler and deformation imaging techniques provide a thorough evaluation of cardiac functions with the advantage of detecting subtle early changes before a global cardiac functional impairment occurs.
Department of Pediatric Oncology, Hacettepe University Institute of Oncology, 06100 Sihhiye, Ankara, Turkey. drbegul@yahoo.com
Begül
B
Yağci-Küpeli
Ali
A
Varan
Hikmet
H
Yorgun
Bariş
B
Kaya
Münevver
M
Büyükpamukçu
D000293:Adolescent; D018943:Anthracyclines / Q000008:administration & dosage / Q000009:adverse effects*; D016022:Case-Control Studies; D002675:Child, Preschool; D003430:Cross-Sectional Studies; D015150:Echocardiography, Doppler / Q000379:methods*; D005260:Female; D006321:Heart / Q000187:drug effects*; D006331:Heart Diseases / Q000139:chemically induced* / Q000000981:diagnostic imaging* / Q000473:pathology; D006801:Humans; D008297:Male; D009200:Myocardial Contraction / Q000187:drug effects; D009206:Myocardium / Q000473:pathology*; D009369:Neoplasms / Q000188:drug therapy*
D018943:Anthracyclines