The involvement of microglial cells in Japanese encephalitis infections.
Despite the availability of effective vaccines, Japanese encephalitis virus (JEV) infections remain a leading cause of encephalitis in many Asian countries. The virus is transmitted to humans by Culex mosquitoes, and, while the majority of human infections are asymptomatic, up to 30% of JE cases admitted to hospital die and 50% of the survivors suffer from neurological sequelae. Microglia are brain-resident macrophages that play key roles in both the innate and adaptive immune responses in the CNS and are thus of importance in determining the pathology of encephalitis as a result of JEV infection.
Department of Biochemistry, Faculty of Medicine, Chulalongkorn University, Bangkok 10330, Thailand.
Thananya
T
Thongtan
Chutima
C
Thepparit
Duncan R
DR
Smith
D000818:Animals; D001921:Brain / Q000276:immunology / Q000378:metabolism / Q000473:pathology / Q000821:virology; D003465:Culex / Q000821:virology; D004664:Encephalitis Virus, Japanese / Q000276:immunology / Q000378:metabolism; D004672:Encephalitis, Japanese / Q000276:immunology* / Q000473:pathology / Q000821:virology; D006801:Humans; D008264:Macrophages / Q000276:immunology* / Q000821:virology*; D017628:Microglia / Q000276:immunology* / Q000378:metabolism / Q000821:virology; D009474:Neurons / Q000378:metabolism / Q000473:pathology / Q000821:virology