Neuronal firing patterns in the subthalamic nucleus in patients with akinetic-rigid-type Parkinson's disease.
Recent studies suggest that Parkinson's disease (PD) is associated with pathological synchronous oscillatory activity in the basal ganglia. Beta frequency band (β-FB) oscillations likely contribute to bradykinesia and rigidity in PD; however, details of the relationship between these two phenomena remain unclear. To explore β-FB oscillatory activity in relation to motor signs of bradykinesia and rigidity, we studied 17 patients with akinetic-rigid type PD who had electrodes implanted into the subthalamic nucleus (STN) for deep brain stimulation therapy. Microelectrode recordings were obtained in the STN during surgery and neuronal activity was analyzed offline. The spectral characteristics were calculated. Of 155 neurons from 30 STN, 56 (36.1%) had β-FB oscillatory activity. Neurons with oscillatory activity were localized in the dorsal two-thirds of the STN. These data indicate that β-FB oscillatory activity may be of particular importance in the generation of motor deficits in PD.
Beijing Institute of Functional Neurosurgery, Xuanwu Hospital, Capital Medical University, Key Laboratory of Neurodegenerative Diseases (Capital Medical University), Ministry of Education, Beijing, China.
Song
S
Guo
Ping
P
Zhuang
Zhe
Z
Zheng
Yuqing
Y
Zhang
Jianyu
J
Li
Yongjie
Y
Li
D000200:Action Potentials / Q000502:physiology*; D000328:Adult; D001683:Biological Clocks; D046690:Deep Brain Stimulation / Q000379:methods*; D004567:Electrodes, Implanted; D005260:Female; D006801:Humans; D018476:Hypokinesia / Q000150:complications / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D009474:Neurons / Q000502:physiology*; D010300:Parkinson Disease / Q000150:complications / Q000628:therapy; D012720:Severity of Illness Index; D020531:Subthalamic Nucleus / Q000473:pathology* / Q000502:physiology*