Facile synthesis of sterically hindered and electron-deficient secondary amides from isocyanates.
The big easy: The direct coupling of Grignard reagents to isocyanates provides a facile and robust solution for the synthesis of sterically hindered and electron-deficient secondary amides. The products are obtained in high yields without the need for excess reagents or chromatographic purification.
Laboratorium für Organische Chemie, Department of Chemistry and Applied Biosciences, ETH Zürich, Zürich, Switzerland.
Gabriel
G
Schäfer
Coraline
C
Matthey
Jeffrey W
JW
Bode
D000577:Amides / Q000138:chemical synthesis / Q000737:chemistry*; D002244:Carbon / Q000737:chemistry; D002264:Carboxylic Acids / Q000737:chemistry; D004583:Electrons; D006219:Halogens / Q000737:chemistry; D017953:Isocyanates / Q000737:chemistry*; D008274:Magnesium / Q000737:chemistry
D000577:Amides; D002264:Carboxylic Acids; D006219:Halogens; D017953:Isocyanates; D002244:Carbon; D008274:Magnesium