[Function of intersectin in endocytosis and exocytosis].
Intersectin is an evolutionarily conserved multifunctional adaptor protein with multifunctional domains. These domains interact with components of the endocytic and exocytic pathways, such as the clathrin mediating synaptic vesicle recycling, the protein related to endocytosis via caveolae, the with-no-lysine kinases related to the regulation of renal outer medullar potassium, and the Cdc42 mediating exocytic pathway. Recently, the understanding of intersectin function in the pathogenesis of endocrine tumor and many neurodegenerative diseases such as Down syndrome, Alzheimer disease has been deepened. This article reviewed the structure and roles in endocytosis/exocytosis and diseases of intersectin.
Tianjin Medical University Cancer Institute and Hospital, Tianjin 300060, China.
Chun-Ying
CY
Tian
Chun-Ling
CL
Zhang
Feng
F
Gu
Yong-Jie
YJ
Ma
D033942:Adaptor Proteins, Vesicular Transport / Q000502:physiology*; D004705:Endocytosis; D005089:Exocytosis; D006801:Humans; D013572:Synaptic Vesicles / Q000502:physiology*
D033942:Adaptor Proteins, Vesicular Transport; C115919:intersectin 1