Impact of infection or vaccination on pre-existing serological memory.
Once established, serum antibody responses against a specific pathogen may last a lifetime. We describe a cohort of four subjects who received smallpox vaccination, and a single subject who received multiple vaccinations, with antibody levels to unrelated antigens monitored for 1-3 years. These immunizations provided the opportunity to determine if infection/vaccination and the resulting toll-like receptor stimulation would alter antigen-specific serological memory to other antigens, including bacterial toxins (tetanus, diphtheria, and pertussis) and viruses (yellow fever virus, measles, mumps, rubella, Epstein-Barr virus, and varicella-zoster virus). Our results indicate that serum IgG levels are remarkably stable and infection or vaccination are unlikely to increase or decrease pre-existing antigen-specific antibody responses.
Oregon National Primate Research Center, Oregon Health & Sciences University, 505 NW 185th Avenue, Beaverton, OR 97006, USA.
Ian J
IJ
Amanna
Erika
E
Hammarlund
Mathew W
MW
Lewis
Mark K
MK
Slifka
D000914:Antibodies, Viral / Q000097:blood / Q000276:immunology; D000917:Antibody Formation / Q000276:immunology*; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood / Q000276:immunology; D007156:Immunologic Memory; D007239:Infections / Q000209:etiology / Q000276:immunology*; D014611:Vaccination; D014612:Vaccines / Q000276:immunology; D014615:Vaccinia / Q000276:immunology; D014616:Vaccinia virus / Q000276:immunology
D000914:Antibodies, Viral; D007074:Immunoglobulin G; D014612:Vaccines