Genetic driver events in premalignancy: LOH validated for marking the risk of oral cancer.
In this issue of the journal (beginning on page 1081), Zhang and colleagues extend the 30-year-old discovery of LOH profiles to provide validated markers of oral premalignant lesion risk for cancer. They prospectively show a dramatic difference in cancer progression between high-risk lesions (LOH) and low-risk (non-LOH) lesions (P = 0.002). This work has important implications for oral cancer prevention and risk modeling and for understanding genetic driver events in premalignancy.
Ludwig Institute for Cancer Research, University of California, San Diego, La Jolla, CA, USA. wcavenee@ucsd.edu
Webster K
WK
Cavenee
D005260:Female; D006801:Humans; D019656:Loss of Heterozygosity / Q000235:genetics*; D008297:Male; D009062:Mouth Neoplasms / Q000235:genetics* / Q000473:pathology*; D011230:Precancerous Conditions / Q000235:genetics* / Q000473:pathology*