Design, synthesis and DNA binding activities of late first row transition metal(II) complexes of bi- functional tri - and tetratopic imines.
A series of novel Co(II), Ni(II), Cu(II) and Zn(II) complexes of tri and tetratopic hydrazones have been prepared. Ligands L(1)H(2) and L(2)H(2) were synthesized by the condensation of 2-formylphenoxyacetic acid with 2-hydrazinobenzothiazole and 2-hydroxy-3-hydrazinebenzopyrazine, respectively. The prepared complexes were characterized by the analytical and spectral techniques. All the complexes were found to be monomeric in nature with octahedral geometry. Both ligands were found to be electrochemically active in the working potential range showing single electron transfer process attributed to the deprotonation of carboxylic group of the 2-formylphenoxyacetic acid. The potency of the ligand and its complexes as antimicrobial agents has been investigated and made to interact with Escherichia coli DNA to investigate the binding/cleaving ability by absorption, hydrodynamic and electrophoresis studies.
Department of Studies in Chemistry, Karnatak University, Pavate Nagar, Dharwad 580 003, Karnataka, India.
Priya P
PP
Netalkar
Anupama
A
Kamath
Sandeep P
SP
Netalkar
Vidyanand K
VK
Revankar
D000900:Anti-Bacterial Agents / Q000494:pharmacology; D056831:Coordination Complexes / Q000138:chemical synthesis* / Q000737:chemistry / Q000378:metabolism*; D053837:DNA Cleavage / Q000187:drug effects; D004269:DNA, Bacterial / Q000378:metabolism*; D004055:Differential Thermal Analysis; D004553:Electric Conductivity; D055664:Electrochemical Techniques; D004578:Electron Spin Resonance Spectroscopy; D004583:Electrons; D004587:Electrophoresis, Agar Gel; D004926:Escherichia coli / Q000187:drug effects / Q000378:metabolism; D007097:Imines / Q000138:chemical synthesis* / Q000737:chemistry / Q000378:metabolism*; D007700:Kinetics; D008024:Ligands; D060328:Magnetic Phenomena; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests; D013055:Spectrophotometry, Infrared; D013056:Spectrophotometry, Ultraviolet; D013818:Thermogravimetry; D028561:Transition Elements / Q000138:chemical synthesis* / Q000737:chemistry / Q000378:metabolism*; D014783:Viscosity / Q000187:drug effects
D000900:Anti-Bacterial Agents; D056831:Coordination Complexes; D004269:DNA, Bacterial; D007097:Imines; D008024:Ligands; D028561:Transition Elements