Pd-catalyzed double C-H bond activation of diaryl ketones for the synthesis of fluorenones.
An efficient synthesis of fluorenones from diaryl ketones by Pd-catalyzed oxidative cyclization is described. A possible mechanism involving a carbonyl group assisted ortho-C-H activation and cyclometalation followed by a second C-H activation to form a six-membered palladacycle and reductive elimination is proposed.
Department of Chemistry, National Tsing Hua University, Hsinchu 30013, Taiwan.
Parthasarathy
P
Gandeepan
Chen-Hsun
CH
Hung
Chien-Hong
CH
Cheng