Executive resting-state network connectivity in migraine without aura.
BACKGROUND
Converging neuropsychological evidence suggests that in migraine executive functions (EF) may be affected during interictal periods.


OBJECTIVE
To evaluate the functional connectivity of the fronto-parietal networks (FPN) known to be associated with EF, in migraine without aura (MwoA) patients, in the interictal period, in comparison to healthy controls (HC).


METHODS
Using resting-state functional MRI (RS-fMRI), we compared functional connectivity within the FPN in 14 patients with MwoA versus 14 sex- and age-matched HC, and assessed the correlation between functional connectivity within FPN, clinical features of MwoA patients, and EF. We used voxel-based morphometry to assess whether between-group differences in functional connectivity were dependent on structural differences.


RESULTS
Neuropsychological data revealed no significant executive dysfunction in MwoA patients. RS-fMRI showed that MwoA patients, compared to HC, had significant functional connectivity reduction within the right FPN and specifically in the middle frontal gyrus (MFG) and the dorsal anterior cingulate cortex. In addition, we found that MFG reduced connectivity was negatively correlated with the pain intensity of migraine attacks. There were no structural differences between the two groups.


CONCLUSIONS
Our data suggest that, even in the absence of clinically evident EF deficits, MwoA is associated with reduced FPN functional connectivity. This study provides further insights into the complex scenario of migraine mechanisms.
Department of Neurological Sciences, Second University of Naples, Naples 80138, Italy.
Antonio
A
Russo
Alessandro
A
Tessitore
Alfonso
A
Giordano
Daniele
D
Corbo
Laura
L
Marcuccio
Manuela
M
De Stefano
Fabrizio
F
Salemi
Renata
R
Conforti
Fabrizio
F
Esposito
Gioacchino
G
Tedeschi
D000328:Adult; D016022:Case-Control Studies; D003071:Cognition; D056344:Executive Function / Q000502:physiology*; D005260:Female; D005625:Frontal Lobe / Q000503:physiopathology*; D006179:Gyrus Cinguli / Q000503:physiopathology; D006801:Humans; D007360:Intelligence; D008279:Magnetic Resonance Imaging; D008297:Male; D020326:Migraine without Aura / Q000503:physiopathology* / Q000523:psychology; D009415:Nerve Net / Q000503:physiopathology*; D009483:Neuropsychological Tests; D058748:Pain Perception / Q000502:physiology; D010296:Parietal Lobe / Q000503:physiopathology*; D011446:Prospective Studies; D055815:Young Adult