Beta-catenin-activated hepatocellular adenoma showing hyperintensity on hepatobiliary-phase gadoxetic-enhanced magnetic resonance imaging and overexpression of OATP8.
We report a male case of beta-catenin-activated hepatocellular adenoma (HCA) focusing on findings of gadoxetic-acid-enhanced magnetic resonance imaging (EOB-MRI) and discussing the molecular background and possible clinical significance. The patient was a 31-year-old man in whom computed tomography (CT) showed a large nodule of 14 cm in diameter in the right liver lobe. On dynamic contrast-enhanced CT, heterogeneous and slight to moderate enhancement was observed during the early phase, with washout in the late phase. Focal fat deposits and a scar-like portion in the lesion were also seen. Most of the lesion was slightly hyperintense compared with the background liver on the hepatobiliary phase of EOB-MRI. After operation, this patient was confirmed pathologically as having beta-catenin-activated HCA with a portion suggestive of malignant transformation. In addition, intense organic anion transporter polypeptide 8 expression was observed throughout the tumor by immunohistochemical staining.
Department of Radiology, Kanazawa University Hospital, 13-1 Takaramachi, Kanazawa 920-8640, Japan. noritin@f7.dion.ne.jp
Norihide
N
Yoneda
Osamu
O
Matsui
Azusa
A
Kitao
Kazuto
K
Kozaka
Toshifumi
T
Gabata
Motoko
M
Sasaki
Yasuni
Y
Nakanuma
Kiyoshi
K
Murata
Toru
T
Tani
D018248:Adenoma, Liver Cell / Q000737:chemistry* / Q000473:pathology*; D000328:Adult; D019786:Gadolinium DTPA; D006801:Humans; D007150:Immunohistochemistry; D008113:Liver Neoplasms / Q000737:chemistry* / Q000473:pathology*; D008279:Magnetic Resonance Imaging; D008297:Male; D029362:Organic Anion Transporters, Sodium-Independent / Q000032:analysis*; D000074542:Solute Carrier Organic Anion Transporter Family Member 1B3; D014057:Tomography, X-Ray Computed; D051176:beta Catenin / Q000502:physiology*
C495270:CTNNB1 protein, human; D029362:Organic Anion Transporters, Sodium-Independent; C421209:SLCO1B3 protein, human; D000074542:Solute Carrier Organic Anion Transporter Family Member 1B3; D051176:beta Catenin; C073590:gadolinium ethoxybenzyl DTPA; D019786:Gadolinium DTPA