Involvement of monoaminergic system in the antidepressant-like effect of riparin I from Aniba riparia (Nees) Mez (Lauraceae) in mice.
In past studies conducted by our group, riparin I (rip I) isolated from the green fruit of Aniba riparia presented antianxiety effects in mice, while its analogs rip II and III showed anxiolytic and antidepressant-like actions. This time around, we investigated a possible antidepressant activity of rip I using the forced swimming test (FST) and tail suspension test (TST) as predictive tests for antidepressant activity in rodents. In addition, the involvement of the monoaminergic system in this effect was also assessed. rip I was acutely administered by intraperitoneal (i.p.) and oral (p.o) routes to male mice at doses of 25 and 50 mg/kg. Results showed that rip I at both tested doses and administration routes produced a significant decrease in immobility time in FST and TST. The pretreatment of mice with prazosin (1 mg/kg, i.p., an α₁ -adrenoceptor antagonist), yohimbine (1 mg/kg, i.p., an α₂ -adrenoceptor antagonist), SCH23390 (15 μg/kg, i.p., a dopamine D1 receptor antagonist), sulpiride (50 mg/kg, i.p., a dopamine D2 receptor antagonist), p-chlorophenylalanine (100 mg/kg, an inhibitor of serotonin synthesis) or ritanserin (4 mg/kg, a serotonin 5-HT2(A)/2(C) receptor antagonist) blocked the anti-immobility effects elicited by rip I (50 mg/kg, p.o.) in the FST. Taken together, results indicate that rip I produces significant antidepressant-like activity in the FST and TST, and this effect seems to be dependent on its interaction with noradrenergic, dopaminergic and serotonergic systems.
Department of Physiology and Pharmacology, Faculty of Medicine, Federal University of Ceará, Rua Cel, Nunes de Melo 1127, 60430-270, Fortaleza-Ceará, Brazil.
Francisca Cléa Florenço
FC
de Sousa
Iris Cristina Maia
IC
Oliveira
Maria Izabel Gomes
MI
Silva
Carla Thiciane Vasconcelos
CT
de Melo
Vívian Romero
VR
Santiago
Raquell
R
de Castro Chaves
Mariana Lima
ML
Fernandes
Stanley Juan Chaves
SJ
Gutierrez
Silvânia Maria Mendes
SM
Vasconcelos
Danielle Silveira
DS
Macêdo
José Maria
JM
Barbosa Filho
D000818:Animals; D014151:Anti-Anxiety Agents / Q000737:chemistry / Q000494:pharmacology; D000928:Antidepressive Agents / Q000737:chemistry* / Q000494:pharmacology*; D001522:Behavior, Animal / Q000187:drug effects*; D001549:Benzamides / Q000494:pharmacology*; D004298:Dopamine / Q000494:pharmacology; D019417:Hindlimb Suspension / Q000379:methods; D019770:Lauraceae / Q000737:chemistry*; D008297:Male; D051379:Mice; D009043:Motor Activity / Q000187:drug effects; D009638:Norepinephrine / Q000494:pharmacology; D013550:Swimming; D014439:Tyramine / Q000031:analogs & derivatives / Q000494:pharmacology*
D014151:Anti-Anxiety Agents; D000928:Antidepressive Agents; D001549:Benzamides; D004298:Dopamine; D009638:Norepinephrine; D014439:Tyramine