DNA damage, chromatin, and transcription: the trinity of aging.
Aging brings about numerous cellular defects. Amongst the most prominent are elevated levels of persistent DNA damage, changes to chromatin structure and epigenetic modifications, and alterations of global transcription programs. These are not independent events and recent work begins to shed light on the intricate interplay between these aging-related defects.
National Cancer Institute, NIH, Bethesda, United States.
Rebecca C
RC
Burgess
Tom
T
Misteli
Philipp
P
Oberdoerffer
D000375:Aging / Q000235:genetics*; D000818:Animals; D002843:Chromatin / Q000235:genetics / Q000378:metabolism*; D004249:DNA Damage / Q000235:genetics; D004260:DNA Repair; D006801:Humans; D012323:RNA Processing, Post-Transcriptional; D015398:Signal Transduction; D014158:Transcription, Genetic
D002843:Chromatin