Cephalosporin-3'-diazeniumdiolates: targeted NO-donor prodrugs for dispersing bacterial biofilms.
Just say NO to biofilms: NO-donors are used to disperse a bacterial biofilm so that co-administered antibiotics will kill the more susceptible unattached cells. The chemically stable cephalosporin-3'-diazeniumdiolate NO-donor prodrug is activated by bacterial β-lactamases and facilitates this two-step biofilm erradication.
School of Biotechnology and Biomolecular Sciences and Centre for Marine Bio-Innovation, University of New South Wales, New South Wales, Australia.
Nicolas
N
Barraud
Bharat G
BG
Kardak
Nageshwar R
NR
Yepuri
Robert P
RP
Howlin
Jeremy S
JS
Webb
Saul N
SN
Faust
Staffan
S
Kjelleberg
Scott A
SA
Rice
Michael J
MJ
Kelso
D000900:Anti-Bacterial Agents / Q000494:pharmacology; D018441:Biofilms / Q000187:drug effects*; D002511:Cephalosporins / Q000737:chemistry*; D020030:Nitric Oxide Donors / Q000737:chemistry / Q000494:pharmacology; D011355:Prodrugs / Q000737:chemistry* / Q000494:pharmacology; D011550:Pseudomonas aeruginosa / Q000502:physiology*; D001618:beta-Lactamases / Q000378:metabolism
D000900:Anti-Bacterial Agents; D002511:Cephalosporins; D020030:Nitric Oxide Donors; D011355:Prodrugs; D001618:beta-Lactamases