Lipid peroxidation and scavenging enzyme levels in the liver of streptozotocin-induced diabetic rats.
In this study, alterations in the liver antioxidant enzymes status and lipid peroxidation in short-term (8-weeks) and long-term (24-weeks) diabetic rats were examined. Glutathione peroxidase (GSH-Px) activity and malondialdehyde (MDA) levels were significantly increased, but superoxide dismutase (SOD) activity was significantly reduced in 8-weeks diabetic rats, compared to control. Catalase (CAT) activity, however, was found unchanged. In 24-weeks diabetic rats, while GSH-Px activity was unchanged, but SOD and CAT activities and MDA levels were significantly increased, compared to control. These results suggest that diabetes-induced alterations in tissue antioxidant system may reflect a generalized increase in tissue oxidative stress. It can be concluded that lipid peroxidation and antioxidant enzyme levels are elevated in diabetic condition. Hence, diabetes mellitus, if left untreated, may increase degenerative processes due to accumulation of oxidative free radicals.
Gazi University, School of Medicine, Department of Biochemistry, Ankara, Turkey. nbukan@yahoo.com
Neslihan
N
Bukan
Banu
B
Sancak
Ozlem
O
Yavuz
Cemile
C
Koca
Funda
F
Tutkun
A Tanju
AT
Ozçelikay
Nilgün
N
Altan
D000818:Animals; D003921:Diabetes Mellitus, Experimental / Q000201:enzymology / Q000378:metabolism*; D016166:Free Radical Scavengers / Q000378:metabolism*; D015227:Lipid Peroxidation; D008099:Liver / Q000201:enzymology* / Q000378:metabolism; D008297:Male; D010088:Oxidoreductases / Q000378:metabolism*; D051381:Rats; D013997:Time Factors
D016166:Free Radical Scavengers; D010088:Oxidoreductases