Reproductive variables and risk of breast malignant and benign tumours in Yunnan province, China.
OBJECTIVE
To compare reproductive factor influence on patients with pathological diagnosed malignant and benign tumor in the Breast Department, The First Peoples' Hospital of Kunming in Yunnan province, China.


METHODS
A hospital-based case-control study was conducted on 263 breast cancer (BC) cases and 457 non-breast cancer controls from 2009 to 2011. The cases and controls information on demographics, medical history, and reproductive characteristics variables were collected using a self-administered questionnaire and routine medical records. Histology of breast cancer tissue and benign breast lesion were documented by pathology reports. Since some variables in data analysis had zero count in at least one category, binomial-response GLM using the bias-reduction method was applied to estimate OR's and their 95% confidence intervals (95% CI). To adjust for age and menopause status, a compound variable comprising age and menopausal status was retained in the statistical models.


RESULTS
multivariate model analysis revealed significant independent positive associations of BC with short menstrual cycle, old age at first live birth, never breastfeeding, history of oral contraception experience, increased number of abortion, postmenopausal status, and nulliparity. Categorised by age and menopausal status, perimenopausal women had about 3-fold and postmenopausal women had more than 5-fold increased risk of BC compared to premenopausal women.


CONCLUSIONS
This study has confirmed the significant association of BC and estrogen related risk factors of breast cancer including longer menstrual cycle, older age of first live birth, never breastfeeding, nulliparity, and number of abortions more than one. The findings suggest that female hormonal factors, especially the trend of menopause status play a significant role in the development of BC in Yunnan women.
Breast Department, The First Peoples' Hospital of Kunming, Yunnan province, PR China.
Che
C
Yanhua
Alan
A
Geater
Jing
J
You
Li
L
Li
Zhou
Z
Shaoqiang
Virasakdi
V
Chongsuvivatwong
Hutcha
H
Sriplung
D000328:Adult; D000367:Age Factors; D000368:Aged; D001942:Breast Feeding / Q000009:adverse effects*; D001943:Breast Neoplasms / Q000209:etiology* / Q000473:pathology*; D016022:Case-Control Studies; D002681:China; D003276:Contraceptives, Oral / Q000009:adverse effects*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008593:Menopause; D008875:Middle Aged; D009367:Neoplasm Staging; D010298:Parity; D011247:Pregnancy; D011379:Prognosis; D012098:Reproduction; D012307:Risk Factors; D055815:Young Adult
D003276:Contraceptives, Oral