Potent antibacterial activity of oligo-3-aminopyridine against Staphylococcus aureus and Enterococcus faecalis.
Oligo-3-aminopyridine (OAP) was tested for its antibacterial activity against two gram positive (Staphylococcus aureus and Enterococcus faecalis) and two gram negative (Escherchia coli and Pseudomonas aeruginosa) bacterial strains. Antibacterial efficacy was measured by disk diffusion assay. Inhibition zones demonstrated that 50 microg OAP showed strong antibacterial activity against the gram-positive strains; the minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) were found to be 25 microg/ml and 50 microg/ml, respectively. The results indicate that OAP is a potent antibacterial agent against S. aureus and E. faecalis.
Canakkale Onsekiz Mart University, Faculty of Arts & Sciences, Department of Chemistry, Terzioglu Campus, 17100 Canakkale, Turkey. cahitakgul@comu.edu.tr
Cahit
C
Akgul
Ismet
I
Kaya
D000631:Aminopyridines / Q000494:pharmacology*; D000890:Anti-Infective Agents / Q000494:pharmacology*; D004058:Diffusion; D004305:Dose-Response Relationship, Drug; D013293:Enterococcus faecalis / Q000187:drug effects*; D008826:Microbial Sensitivity Tests; D008956:Models, Chemical; D010100:Oxygen / Q000737:chemistry; D013045:Species Specificity; D013211:Staphylococcus aureus / Q000187:drug effects*; D013696:Temperature
D000631:Aminopyridines; D000890:Anti-Infective Agents; D010100:Oxygen