Improving IMRT-plan quality with MLC leaf position refinement post plan optimization.
OBJECTIVE
In intensity-modulated radiation therapy (IMRT) planning, reducing the pencil-beam size may lead to a significant improvement in dose conformity, but also increase the time needed for the dose calculation and plan optimization. The authors develop and evaluate a postoptimization refinement (POpR) method, which makes fine adjustments to the multileaf collimator (MLC) leaf positions after plan optimization, enhancing the spatial precision and improving the plan quality without a significant impact on the computational burden.


METHODS
The authors' POpR method is implemented using a commercial treatment planning system based on direct aperture optimization. After an IMRT plan is optimized using pencil beams with regular pencil-beam step size, a greedy search is conducted by looping through all of the involved MLC leaves to see if moving the MLC leaf in or out by half of a pencil-beam step size will improve the objective function value. The half-sized pencil beams, which are used for updating dose distribution in the greedy search, are derived from the existing full-sized pencil beams without need for further pencil-beam dose calculations. A benchmark phantom case and a head-and-neck (HN) case are studied for testing the authors' POpR method.


RESULTS
Using a benchmark phantom and a HN case, the authors have verified that their POpR method can be an efficient technique in the IMRT planning process. Effectiveness of POpR is confirmed by noting significant improvements in objective function values. Dosimetric benefits of POpR are comparable to those of using a finer pencil-beam size from the optimization start, but with far less computation and time.


CONCLUSIONS
The POpR is a feasible and practical method to significantly improve IMRT-plan quality without compromising the planning efficiency.
Department of Physics, The George Washington University, Washington, DC 20052 , USA.
Ying
Y
Niu
Guowei
G
Zhang
Barry L
BL
Berman
William C
WC
Parke
Byongyong
B
Yi
Cedric X
CX
Yu
D000465:Algorithms; D003198:Computer Simulation; D004307:Dose-Response Relationship, Radiation; D004867:Equipment Design; D006258:Head and Neck Neoplasms / Q000532:radiotherapy*; D006801:Humans; D009959:Oropharyngeal Neoplasms / Q000532:radiotherapy; D019047:Phantoms, Imaging; D011874:Radiometry / Q000379:methods; D011880:Radiotherapy Planning, Computer-Assisted / Q000379:methods*; D050397:Radiotherapy, Intensity-Modulated / Q000295:instrumentation* / Q000379:methods*; D015203:Reproducibility of Results; D014018:Tissue Distribution