[Therapeutic siRNAs and non-viral systems for their delivery].
Gene-directed therapy with small interfer-ring RNA (siRNA) has a tremedous potential and in the future will undoubtly occupy one of the leading positions among other therapeutic methods. The lack of efficient and targeted delivery vectors delays the successful implementation of this method in clinic. To develop such systems, one needs a comprehansive insight into the processes of interactions between siRNAs, its delivery systems and an organism. This review covers properties of therapeutic siRNAs and non-viral systems for their delivery.
K V
KV
Glebova
A V
AV
Marakhonov
A V
AV
Baranova
M Iu
MIu
Skoblov
D052157:Aptamers, Nucleotide / Q000737:chemistry; D016503:Drug Delivery Systems / Q000379:methods*; D015316:Genetic Therapy; D018056:Hemorheology; D006801:Humans; D008081:Liposomes / Q000737:chemistry; D053758:Nanoparticles / Q000737:chemistry; D010316:Particle Size; D034622:RNA Interference; D034741:RNA, Small Interfering / Q000737:chemistry* / Q000235:genetics; D055672:Static Electricity
D052157:Aptamers, Nucleotide; D008081:Liposomes; D034741:RNA, Small Interfering