Hematopoietic stem cell mobilization with G-CSF.
Cytokine mobilized peripheral blood stem cells are the preferred source of stem cells in autologous stem cell transplantation and have virtually replaced bone marrow as the stem cell source. In recent years, a dramatic increase has been reported in the use of peripheral blood stem cells for allogeneic transplantation as well. The reason for this rise is that peripheral blood stem cell transplants when compared to bone marrow transplants are associated with a more rapid recovery of granulocytes and platelets after transplantation and a lower regimen-related and transplant-related mortality. Peripheral blood stem cells can be easily harvested on an outpatient basis without the need for general anesthesia. In most cases peripheral blood stem cells are collected after G-CSF administration. In this chapter we describe peripheral blood stem cell mobilization in autologous transplant patients and in allogeneic donors using G-CSF.
Department of Stem Cell Transplantation and Cell Therapy, M.D. Anderson Cancer Center, Houston, TX, USA. cmhosing@mdanderson.org
Chitra
C
Hosing
D018952:Antigens, CD34 / Q000378:metabolism; D016207:Cytokines / Q000008:administration & dosage / Q000494:pharmacology; D000069585:Filgrastim; D016179:Granulocyte Colony-Stimulating Factor / Q000008:administration & dosage / Q000009:adverse effects / Q000494:pharmacology*; D019650:Hematopoietic Stem Cell Mobilization / Q000379:methods*; D006412:Hematopoietic Stem Cells / Q000187:drug effects / Q000378:metabolism; D006801:Humans; D011092:Polyethylene Glycols; D011994:Recombinant Proteins / Q000008:administration & dosage / Q000009:adverse effects / Q000494:pharmacology
D018952:Antigens, CD34; D016207:Cytokines; D011994:Recombinant Proteins; D016179:Granulocyte Colony-Stimulating Factor; C455861:pegfilgrastim; D011092:Polyethylene Glycols; D000069585:Filgrastim