Personalized image-based radiation dosimetry for routine clinical use in peptide receptor radionuclide therapy: pretherapy experience.
Patient-specific dose calculations are not routinely performed for targeted radionuclide therapy procedures, partly because they are time consuming and challenging to perform. However, it is becoming widely recognized that a personalized dosimetry approach can help plan treatment and improve understanding of the dose-response relationship. In this chapter, we review the procedures and essential elements of an accurate internal dose calculation and propose a simplified approach that is aimed to be practical for use in a busy nuclear medicine department.
University of British Columbia, Vancouver Coastal Health Research Institute, Vancouver, Canada.
Anna
A
Celler
Joshua
J
Grimes
Sergey
S
Shcherbinin
Hanna
H
Piwowarska-Bilska
Bozena
B
Birkenfeld
D001330:Electronic Data Processing; D006801:Humans; D007091:Image Processing, Computer-Assisted; D064847:Multimodal Imaging; D049268:Positron-Emission Tomography; D057285:Precision Medicine; D011874:Radiometry; D019275:Radiopharmaceuticals / Q000627:therapeutic use*; D011879:Radiotherapy Dosage; D018000:Receptors, Peptide / Q000032:analysis*; D014057:Tomography, X-Ray Computed
D019275:Radiopharmaceuticals; D018000:Receptors, Peptide