Carcinoma of donor origin after allogeneic peripheral blood stem cell transplantation.
Secondary cancers developing after allogeneic hematopoietic stem cell transplantation generally originate from recipient-derived cells. In this study, we analyzed the tumor cell origin of 5 epithelial malignant tumors (esophageal squamous cell carcinoma, lung adenocarcinoma, gastric adenocarcinoma, pharyngeal squamous cell carcinoma, and thyroid papillary carcinoma) that developed after allogeneic peripheral blood stem cell transplantation using anti-AE1/3 immunofluorescence with fluorescence in situ hybridization analysis for sex chromosomes and/or short-tandem repeat microsatellite analysis of laser-microdissected tumor cells. The results revealed that 1 of these 5 cancers was derived from donor cells. In this case, transfused pluripotent cells, which include both mesenchymal stem cells and hematopoietic stem cells, might have given rise to epithelial malignant cells. Our observations suggest that transfused peripheral blood cells may be involved in the development of cancers after allogeneic peripheral blood stem cell transplantation.
Departments of Hematology and Hematopoietic Stem Cell Transplantation, Division of Thoracic Surgery, National Cancer Center Hospital, Chuo-ku, Tokyo, Japan.
Wataru
W
Munakata
Junko
J
Nomoto
Noriko
N
Takahashi
Hirokazu
H
Taniguchi
Akiko Miyagi
AM
Maeshima
Hisao
H
Asamura
Ryuji
R
Tanosaki
Yuji
Y
Heike
Takahiro
T
Fukuda
Kensei
K
Tobinai
Yukio
Y
Kobayashi
D000230:Adenocarcinoma / Q000209:etiology* / Q000235:genetics / Q000473:pathology; D000231:Adenocarcinoma, Papillary / Q000209:etiology* / Q000235:genetics / Q000473:pathology; D000328:Adult; D001457:Anion Exchange Protein 1, Erythrocyte / Q000235:genetics; D017920:Antiporters / Q000235:genetics; D001854:Bone Marrow Cells / Q000737:chemistry / Q000473:pathology; D002294:Carcinoma, Squamous Cell / Q000209:etiology* / Q000235:genetics / Q000473:pathology; D019070:Cell Lineage; D004273:DNA, Neoplasm / Q000032:analysis; D004938:Esophageal Neoplasms / Q000209:etiology / Q000235:genetics / Q000473:pathology; D005260:Female; D019084:Fluorescent Antibody Technique, Indirect; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D061346:Laser Capture Microdissection; D008175:Lung Neoplasms / Q000209:etiology / Q000235:genetics / Q000473:pathology; D008297:Male; D018895:Microsatellite Repeats / Q000235:genetics; D008875:Middle Aged; D009378:Neoplasms, Multiple Primary / Q000209:etiology* / Q000235:genetics / Q000473:pathology; D036102:Peripheral Blood Stem Cell Transplantation / Q000009:adverse effects*; D010610:Pharyngeal Neoplasms / Q000209:etiology / Q000235:genetics / Q000473:pathology; D012730:Sex Chromosomes / Q000235:genetics; D013274:Stomach Neoplasms / Q000209:etiology / Q000235:genetics / Q000473:pathology; D013964:Thyroid Neoplasms / Q000209:etiology / Q000235:genetics / Q000473:pathology; D014019:Tissue Donors; D018183:Transplantation Chimera
D001457:Anion Exchange Protein 1, Erythrocyte; D017920:Antiporters; D004273:DNA, Neoplasm; C489237:SLC4A3 protein, human