Hybrid microparticles for drug delivery and magnetic resonance imaging.
In this work, we report the synthesis, characterization, and possible application as drug-delivery system magnetically triggered, of hybrid microparticles formed by magnetic nanoparticles embedded within poly(ε-caprolactone). The magnetism of the microparticles permits their localization within the body using magnetic resonance imaging, and the biodegradable polymer layer allows entrapping drugs that can be released when temperature increases. The synthesis of the hybrid material was performed using "grafting from" technique of conveniently modified magnetic nanoparticles. Subsequently, the resulting hybrid nanoparticles were assembled into spherical particles of 138 ± 49 nm via precipitation technique. The produced hybrid material was evaluated as stimuli-responsive drug delivery system in which the release of the drug was triggered by magnetic induction. Furthermore, the microparticles were injected in rats and their localization within the animal was monitored using the local field inhomogeneities generated by the particles.
Department of Physical Chemistry II, Faculty of Pharmacy, Complutense University of Madrid, Madrid, Spain.
David
D
Serrano-Ruiz
Marco
M
Laurenti
Jesús
J
Ruiz-Cabello
Enrique
E
López-Cabarcos
Jorge
J
Rubio-Retama
D000818:Animals; D001672:Biocompatible Materials / Q000737:chemistry; D003374:Coumarins / Q000737:chemistry; D016503:Drug Delivery Systems; D005290:Ferric Compounds / Q000737:chemistry; D008027:Light; D008279:Magnetic Resonance Imaging; D058185:Magnetite Nanoparticles / Q000737:chemistry*; D008297:Male; D046529:Microscopy, Electron, Transmission; D036103:Nanotechnology / Q000379:methods*; D011091:Polyesters / Q000737:chemistry; D011108:Polymers / Q000737:chemistry; D051381:Rats; D017208:Rats, Wistar; D012542:Scattering, Radiation; D013050:Spectrometry, Fluorescence; D017550:Spectroscopy, Fourier Transform Infrared; D013696:Temperature
D001672:Biocompatible Materials; D003374:Coumarins; D005290:Ferric Compounds; D058185:Magnetite Nanoparticles; D011091:Polyesters; D011108:Polymers; C000499:ferric oxide; C016240:polycaprolactone; C030123:coumarin