Oxidative stress and inflammation biomarkers in the blood of patients with Huntington's disease.
OBJECTIVE
Huntington's disease (HD) is a neurodegenerative disorder for which there is no effective treatment. Oxidative stress and inflammation are known to be involved in HD, but the precise relationship between the two remains unclear. The aim of this study was to  analyze oxidative stress and inflammation biomarkers in blood of patients with HD with a view to identifying potential links between them.


METHODS
Blood samples were collected from 13 patients with HD and from 10 age- and sex-matched controls, and the following were measured: C-reactive  proteins, myeloperoxidase (MPO)/white blood cell (WBC) ratio, interleukin-6 (IL-6), thioredoxin reductase-1 (TrRd-1), thioredoxin-1 (Trx-1), total nitrites (NOx), nitric oxide synthase (NOS) and nitrotyrosine.


RESULTS
Results showed that HD is associated to a reduction of TrRd-1  and Trx-1 levels in plasma and erythrocytes, and with an increase in the MPO/WBC ratio. A positive correlation was observed between global oxidative stress (GOS) and MPO/WBC. No changes were found in NOS and Nox levels with respect to controls.


CONCLUSIONS
Oxidative damage may be  linked to the inflammatory response in HD, via a peripheral immune response.
Servicio de Neurología, Instituto Maimónides de Investigación Biomédica de Córdoba (IMIBIC)/Hospital Universitario Reina Sofía de Córdoba, Córdoba, España.
Fernando
F
Sánchez-López
Inmaculada
I
Tasset
Eduardo
E
Agüera
Montserrat
M
Feijóo
Ricardo
R
Fernández-Bolaños
Francisco M
FM
Sánchez
María C
MC
Ruiz
Antonio H
AH
Cruz
Félix
F
Gascón
Isaac
I
Túnez
D000328:Adult; D015415:Biomarkers / Q000097:blood; D005260:Female; D006801:Humans; D006816:Huntington Disease / Q000097:blood* / Q000473:pathology* / Q000503:physiopathology; D007249:Inflammation / Q000097:blood / Q000175:diagnosis / Q000473:pathology / Q000503:physiopathology; D018836:Inflammation Mediators / Q000097:blood*; D008297:Male; D008875:Middle Aged; D018384:Oxidative Stress / Q000502:physiology*
D015415:Biomarkers; D018836:Inflammation Mediators