The endoplasmic reticulum in cardiovascular health and disease.
The endoplasmic reticulum has an intricate network of pathways built to deal with the secretory and integral membrane protein synthesis demands of the cell, as well as adaptive responses set up for the endoplasmic reticulum to rely on when stressed. These pathways are both essential and complex, and because of these 2 factors, several situations can lead to a dysfunctional endoplasmic reticulum and result in a dysfunctional cell with the potential to contribute to the progression of disease. The endoplasmic reticulum has been implicated in several metabolic, neurodegenerative, inflammatory, autoimmune, and renal diseases and disorders, and in particular, cardiovascular diseases. The role of the endoplasmic reticulum in cardiovascular disease shows how the change in function of a particular microscopic organelle can lead to macroscopic changes in the form of disease.
Department of Biochemistry, University of Alberta, Edmonton, Canada.
Robyn
R
Millott
Elzbieta
E
Dudek
Marek
M
Michalak
D000818:Animals; D017209:Apoptosis; D001343:Autophagy; D001562:Benzimidazoles / Q000008:administration & dosage / Q000627:therapeutic use; D001565:Benzoates / Q000008:administration & dosage / Q000627:therapeutic use; D002318:Cardiovascular Diseases / Q000378:metabolism / Q000473:pathology / Q000517:prevention & control; D004721:Endoplasmic Reticulum / Q000187:drug effects / Q000378:metabolism / Q000473:pathology / Q000502:physiology*; D059865:Endoplasmic Reticulum Stress / Q000187:drug effects / Q000502:physiology; D006321:Heart / Q000196:embryology; D006801:Humans; D038081:Organogenesis / Q000502:physiology; D012991:Solanaceous Alkaloids / Q000008:administration & dosage / Q000627:therapeutic use; D000077333:Telmisartan; D016896:Treatment Outcome; D056811:Unfolded Protein Response / Q000502:physiology
D001562:Benzimidazoles; D001565:Benzoates; D012991:Solanaceous Alkaloids; C003922:anisodamine; D000077333:Telmisartan