Phosphatase reactivity of a dicopper(II) complex of a patellamide derivative--possible biological functions of cyclic pseudopeptides.
A possible biological function of cyclic pseudo-octapeptides is presented. The dinuclear copper(II) complex of a synthetic analogue ([Cu(2)(H(2)Pat(1))(μ-OH)(OH(2))(2)]) of the naturally occurring ascidiacyclamide is known to have a hydroxo-bridged dicopper(II) site which is able to catalytically transform CO(2) into CO(3)(2-). This complex is shown here to function as a phosphatase mimic, suggesting that the so far unknown biological function of these macrocycles within the ascidians may involve phosphoester hydrolysis.
Universität Heidelberg, Anorganisch-Chemisches Institut, INF 270, D-69120 Heidelberg, Germany. peter.comba@aci.uni-heidelberg.de
Peter
P
Comba
Lawrence R
LR
Gahan
Graeme R
GR
Hanson
Michael
M
Westphal
D003300:Copper / Q000737:chemistry*; D008958:Models, Molecular; D008968:Molecular Conformation; D009942:Organometallic Compounds / Q000737:chemistry*; D057786:Peptidomimetics / Q000737:chemistry* / Q000378:metabolism; D010744:Phosphoric Monoester Hydrolases / Q000378:metabolism*
D009942:Organometallic Compounds; D057786:Peptidomimetics; D003300:Copper; D010744:Phosphoric Monoester Hydrolases