Phragmalin-type limonoids from Heynea trijuga.
Nine new phragmalin-type limonoids, heytrijumalins A-I (1-9), together with the known 15-acetyltrichagmalin E (10) were isolated from the branches and leaves of Heynea trijuga. The structures of these new compounds were elucidated on the basis of extensive spectroscopic analysis. Compounds 6 and 10 showed insecticidal activity at 100 ppm, with corrected mortalities of 82.94 % and 96.02 %, respectively. Compounds 2 and 10 showed weak cytotoxicity against HL-60 and A-549 human tumor cell lines, with IC₅₀ values ranging from 14.55 to 25.27 µM.
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, PR China.
Wei
W
Yang
Lingmei
L
Kong
Yu
Y
Zhang
Guihua
G
Tang
Feng
F
Zhu
Shifei
S
Li
Lingli
L
Guo
Yuanyuan
Y
Cheng
Xiaojiang
X
Hao
Hongping
H
He
D001681:Biological Assay; D045744:Cell Line, Tumor; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D006801:Humans; D020128:Inhibitory Concentration 50; D007306:Insecticides / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D036701:Limonins / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D029582:Meliaceae / Q000737:chemistry*; D008958:Models, Molecular; D015394:Molecular Structure; D018515:Plant Leaves / Q000737:chemistry; D018547:Plant Stems / Q000737:chemistry
C557392:15-acetyltrichagmalin E; D004365:Drugs, Chinese Herbal; D007306:Insecticides; D036701:Limonins