Clinical translation of cell-based pharmacogenomic discovery.
The use of cell-based models has emerged as a promising means to discover and validate pharmacologic phenotype-genotype relationships. The availability of large-scale genome studies in both human and model systems is now allowing us an unprecedented opportunity to understand how well cell-based models identify clinically relevant genetic variants associated with drug response and toxicity. Here we review these studies and the emerging translational information.
Committee on Clinical Pharmacology and Pharmacogenomics, Department of Medicine, University of Chicago, Chicago, Illinois, USA.
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Cox
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Gamazon
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Wheeler
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Dolan
D000818:Animals; D045744:Cell Line, Tumor; D055808:Drug Discovery / Q000379:methods* / Q000639:trends; D023281:Genomics / Q000379:methods / Q000639:trends; D006801:Humans; D010597:Pharmacogenetics / Q000379:methods* / Q000639:trends; D020641:Polymorphism, Single Nucleotide / Q000235:genetics; D057170:Translational Research, Biomedical / Q000379:methods* / Q000639:trends