No association between the USP7 gene polymorphisms and colorectal cancer in the Chinese Han population.
Colorectal cancer (CRC), now the third most common cancer across the world, is known to aggregate in families. USP7 is a very important protein with an important role in regulating the p53 pathway, which is critical for genomic stability and tumor suppression. We here genotyped eight SNPs within the USP7 gene and conducted a case-control study in 312 CRC patients and 270 healthy subjects in the Chinese Han population. No significant associations were found for any single SNP and CRC risk. Our data eliminate USP7 as a potential candidate gene towards for CRC in the Han Chinese population.
Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders (Ministry of Education), Shanghai Jiao Tong University, Shanghai, China.
Xin
X
Li
Yang
Y
Wang
Xing-Wang
XW
Li
Bao-Cheng
BC
Liu
Qing-Zhu
QZ
Zhao
Wei-Dong
WD
Li
Shi-Qing
SQ
Chen
Xiao-Ye
XY
Huang
Feng-Ping
FP
Yang
Quan
Q
Wang
Jin-Fen
JF
Wang
Yan-Zeng
YZ
Xiao
Yi-Feng
YF
Xu
Guo-Yin
GY
Feng
Zhi-Hai
ZH
Peng
Lin
L
He
Guang
G
He
D000328:Adult; D044466:Asian People / Q000235:genetics*; D016022:Case-Control Studies; D003106:Colon / Q000378:metabolism; D015179:Colorectal Neoplasms / Q000235:genetics* / Q000473:pathology; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006239:Haplotypes / Q000235:genetics; D006801:Humans; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D011379:Prognosis; D012007:Rectum / Q000378:metabolism; D012307:Risk Factors; D043222:Ubiquitin Thiolesterase / Q000235:genetics*; D000076084:Ubiquitin-Specific Peptidase 7
C464569:USP7 protein, human; D043222:Ubiquitin Thiolesterase; D000076084:Ubiquitin-Specific Peptidase 7