A modified regimen of extracorporeal cardiac shock wave therapy for treatment of coronary artery disease.
BACKGROUND
Cardiac shock wave therapy (CSWT) improves cardiac function in patients with severe coronary artery disease (CAD). We aimed to evaluate the clinical outcomes of a new CSWT treatment regimen.


METHODS
The 55 patients with severe CAD were randomly divided into 3 treatment groups. The control group (n = 14) received only medical therapy. In group A ( n = 20), CSWT was performed 3 times within 3 months. In group B ( n = 21), patients underwent 3 CSWT sessions/week, and 9 treatment sessions were completed within 1 month. Primary outcome measurement was 6-minute walk test (6MWT). Other measurements were also evaluated.


RESULTS
The 6MWT, CCS grading of angina, dosage of nitroglycerin, NYHA classification, and SAQ scores were improved in group A and B compared to control group.


CONCLUSIONS
A CSWT protocol with 1 month treatment duration showed similar therapeutic efficacy compared to a protocol of 3 months duration.


BACKGROUND
We have registered on ClinicalTrials.gov, the protocol ID is CSWT IN CHINA.
Department of Cardiology, 1st Hospital of Kunming Medical University, Kunming, Yunnan, PRC.
Yu
Y
Wang
Tao
T
Guo
Tie-Kun
TK
Ma
Hong-Yan
HY
Cai
Si-Ming
SM
Tao
Yun-Zhu
YZ
Peng
Ping
P
Yang
Ming-Qing
MQ
Chen
Yun
Y
Gu
D000368:Aged; D000787:Angina Pectoris / Q000209:etiology / Q000517:prevention & control; D003324:Coronary Artery Disease / Q000150:complications / Q000503:physiopathology / Q000628:therapy*; D017079:Exercise Tolerance; D005260:Female; D005500:Follow-Up Studies; D019220:High-Energy Shock Waves / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D016896:Treatment Outcome