Tropical distal renal tubular acidosis: clinical and epidemiological studies in 78 patients.
BACKGROUND
Distal renal tubular acidosis (dRTA) caused by mutations of the SLC4A1 gene encoding the erythroid and kidney isoforms of anion exchanger 1 (AE1 or band 3) has a high prevalence in some tropical countries, particularly Thailand, Malaysia, the Philippines and Papua New Guinea (PNG). Here the disease is almost invariably recessive and can result from either homozygous or compound heterozygous SLC4A1 mutations.


METHODS
We have collected and reviewed our own and published data on tropical dRTA to provide a comprehensive series of clinical and epidemiological studies in 78 patients.


RESULTS
Eight responsible SLC4A1 mutations have been described so far, four of them affecting multiple unrelated families. With the exception of the mutation causing South-East Asian ovalocytosis (SAO), none of these mutations has been reported outside the tropics, where dRTA caused by SLC4A1 mutations is much rarer and almost always dominant, resulting from mutations that are quite different from those found in the tropics. SLC4A1 mutations, including those causing dRTA, may cause morphological red cell changes, often with excess haemolysis. In dRTA, these red cell changes are usually clinically recessive and not present in heterozygotes. The high tropical prevalence of dRTA caused by SLC4A1 mutations is currently unexplained.


CONCLUSIONS
A hypothesis suggesting that changes in red cell metabolism caused by these mutations might protect against malaria is put forward to explain the phenomenon, and a possible mechanism for this effect is proposed.
University College Medical School, Royal Free Campus and Hospital, London NW3 2PF, UK.
S
S
Khositseth
L J
LJ
Bruce
S B
SB
Walsh
W M
WM
Bawazir
G D
GD
Ogle
R J
RJ
Unwin
M-K
MK
Thong
R
R
Sinha
K E
KE
Choo
W
W
Chartapisak
P
P
Kingwatanakul
A
A
Sumboonnanonda
S
S
Vasuvattakul
P
P
Yenchitsomanus
O
O
Wrong
D000141:Acidosis, Renal Tubular / Q000453:epidemiology / Q000235:genetics*; D001457:Anion Exchange Protein 1, Erythrocyte / Q000235:genetics* / Q000378:metabolism; D001208:Asia / Q000453:epidemiology; D002648:Child; D002675:Child, Preschool; D003241:Consanguinity; D004913:Erythrocytes, Abnormal / Q000378:metabolism / Q000502:physiology; D005260:Female; D006402:Hematologic Diseases / Q000453:epidemiology / Q000235:genetics; D006579:Heterozygote; D006720:Homozygote; D006801:Humans; D007223:Infant; D008288:Malaria / Q000235:genetics; D008297:Male; D009154:Mutation / Q000235:genetics*; D010219:Papua New Guinea / Q000453:epidemiology; D010375:Pedigree; D010641:Phenotype; D010679:Philippines / Q000453:epidemiology; D013785:Thailand / Q000453:epidemiology
D001457:Anion Exchange Protein 1, Erythrocyte; C454201:SLC4A1 protein, human