A novel G1 checkpoint mediated by the p57 CDK inhibitor and p38 SAPK promotes cell survival upon stress.
Comment on: Joaquin M, et al. EMBO J 2012; 31:2952-64.
Manel
M
Joaquin
Albert
A
Gubern
Francesc
F
Posas
D000818:Animals; D002470:Cell Survival; D050761:Cyclin-Dependent Kinase Inhibitor p57 / Q000378:metabolism*; D004789:Enzyme Activation; D059585:G1 Phase Cell Cycle Checkpoints; D006801:Humans; D008954:Models, Biological; D009997:Osmotic Pressure; D010766:Phosphorylation; D013312:Stress, Physiological; D048051:p38 Mitogen-Activated Protein Kinases / Q000378:metabolism*
D050761:Cyclin-Dependent Kinase Inhibitor p57; D048051:p38 Mitogen-Activated Protein Kinases