Five-year incidence of retinal microvascular abnormalities and associations with arterial hypertension: the Beijing Eye Study 2001/2006.
OBJECTIVE
To describe the 5-year incidence of retinal microvascular abnormalities and analyze their associations with arterial hypertension in nondiabetic elderly Chinese subjects in urban and rural Beijing in a follow-up of the original Beijing Eye Study 2001.


METHODS
Population-based study.


METHODS
The Beijing Eye Study 2006 included 3251 subjects who had participated in the Beijing Eye Study 2001 and returned for reexamination.


METHODS
By using fundus photographs, we determined the 5-year incidence and change (progression or regression) of retinal microvascular abnormalities, including focal narrowing (FN) of retinal arterioles, arteriovenous nicking (AVN), and retinopathy. Arterial hypertension was graded as controlled treated arterial hypertension, uncontrolled treated arterial hypertension, and untreated arterial hypertension.


METHODS
Incidence of retinal microvascular abnormalities.


RESULTS
After excluding patients with diabetes mellitus or any retinal or optic nerve disease, 2058 subjects (1409 women [68.5%]) were included in the study. The mean age of subjects was 53.8 ± 9.5 years, and the mean refractive error was -0.24 ± 2.04 diopters. The 5-year accumulated incidence of FN, AVN, and retinopathy was 4.1%, 1.4%, and 3.3%, respectively. Adjusted for age, gender, and region of habitation, the 5-year incidence of FN, AVN, and retinopathy increased 1.58 times (95% confidence interval [CI], 1.24-2.00; P<0.001), 1.55 times (95% CI, 1.04-2.32; P = 0.03), and 1.46 times (95% CI, 1.12-1.91; P = 0.005), respectively, for every 10 mmHg increase in mean arterial blood pressure. After adjusting for age, gender, and region of habitation, the rate of regression of FN decreased by 28% with every increase in the grade of the arterial hypertension classification. Correspondingly, the rate of regression of FN was significantly higher in the group with controlled arterial hypertension (44.4%) than in the uncontrolled (22.6%) and untreated (11.5%) groups (P = 0.01).


CONCLUSIONS
Arterial hypertension was strongly associated with the incidence and longitudinal change of retinal microvascular abnormalities in nondiabetic subjects. Better control of arterial hypertension was correlated with a decreased incidence of retinal microvascular abnormalities and an increased rate of regression of FN. This suggests that retinal FN as potentially the first step of retinal microvascular abnormalities is reversible if arterial hypertension is controlled.


BACKGROUND
The author(s) have no proprietary or commercial interest in any materials discussed in this article.
Beijing Institute of Ophthalmology, Beijing Tongren Hospital, Capital University of Medical Science, Beijing, China.
Shuang
S
Wang
Liang
L
Xu
Jost B
JB
Jonas
Yun Song
YS
Wang
Ya Xing
YX
Wang
Qi Sheng
QS
You
Hua
H
Yang
Jin Qiong
JQ
Zhou
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D062186:Arterial Pressure; D001160:Arterioles / Q000473:pathology; D044466:Asian People / Q000208:ethnology*; D002681:China / Q000453:epidemiology; D005260:Female; D006801:Humans; D006973:Hypertension / Q000175:diagnosis / Q000208:ethnology* / Q000503:physiopathology; D015994:Incidence; D008297:Male; D008875:Middle Aged; D012164:Retinal Diseases / Q000208:ethnology* / Q000503:physiopathology; D012171:Retinal Vessels / Q000473:pathology*; D012424:Rural Population / Q000706:statistics & numerical data*; D014505:Urban Population / Q000706:statistics & numerical data*; D014699:Venules / Q000473:pathology