Mechanistic studies on the reactions of platinum(II) complexes with nitrogen- and sulfur-donor biomolecules.
A brief overview of mechanistic studies on the reactions of different Pt(II) complexes with nitrogen- and sulfur-donor biomolecules is presented. The first part describes the results obtained for substitution reactions of mono-functional Pt(II) complexes with different biomolecules, under various experimental conditions (temperature, pH and ionic strength). In addition, an overview of the results obtained for the substitution reactions of bi-functional Pt(II) complexes, analogous to cisplatin, with biomolecules is given. The last part of this report deals with different polynuclear Pt(II) complexes and their substitution behaviour with different biomolecules. The purpose of this perspective is to improve the understanding of the mechanism of action of Pt(II) complexes as potential anti-tumour drugs in the human body.
Department of Chemistry, Faculty of Science, University of Kragujevac, R. Domanovića 12, 34000 Kragujevac, Serbia. bugarcic@kg.ac.rs
Živadin D
ŽD
Bugarčić
Jovana
J
Bogojeski
Biljana
B
Petrović
Stephanie
S
Hochreuther
Rudi
R
van Eldik
D000970:Antineoplastic Agents / Q000737:chemistry / Q000494:pharmacology*; D056831:Coordination Complexes / Q000737:chemistry / Q000494:pharmacology*; D006801:Humans; D009584:Nitrogen / Q000737:chemistry; D009944:Organoplatinum Compounds / Q000737:chemistry / Q000494:pharmacology; D010984:Platinum / Q000737:chemistry / Q000494:pharmacology*; D017671:Platinum Compounds / Q000737:chemistry / Q000494:pharmacology; D013455:Sulfur / Q000737:chemistry
D000970:Antineoplastic Agents; D056831:Coordination Complexes; D009944:Organoplatinum Compounds; D017671:Platinum Compounds; D010984:Platinum; D013455:Sulfur; D009584:Nitrogen