The clinical profile of Merkel cell carcinoma in mainland China.
BACKGROUND
Merkel cell carcinoma (MCC) is an aggressive cutaneous malignancy, but little is known about the presence or characteristics of MCC in mainland China. A retrospective chart review was conducted to describe the clinical profile of MCC in China.


METHODS
At 18 cancer or dermatology hospitals in metropolitan centers from the six geographical regions of mainland China, approximately 3,100,000 pathology database and medical records were searched for cases that had a pathological diagnosis of MCC between 1970 and 2009. A case series was compiled from retrospective chart reviews of identified patients with MCC.


RESULTS
Eight out of 18 participating hospitals reported at least one record of a patient with a pathological diagnosis of MCC, and a total of 22 cases were identified. The median age of patients was 65.5 years, and 59% were female. The median time from the appearance of a lesion to the time of biopsy was six months, and the most common location of lesions was the head and neck. The most common treatment used was surgery alone.


CONCLUSIONS
Merkel cell carcinoma appears to be uncommon in mainland China. Patients in this series are elderly, often had lesions on the head/neck region, and most commonly received surgery alone as treatment. In contrast with MCC in Western countries, the current series' patients were all of Asian ethnicity, had larger lesions at presentation, and none was documented as having HIV or other forms of immunosuppression.
Department of Cancer Epidemiology, Cancer Institute, Chinese Academy of Medical Sciences, Beijing, China.
Philip I
PI
Song
Hao
H
Liang
Wen-Qiang
WQ
Wei
Yi-Qun
YQ
Jiang
Jennifer S
JS
Smith
You-Lin
YL
Qiao
D000328:Adult; D000368:Aged; D044466:Asian People; D001706:Biopsy; D015266:Carcinoma, Merkel Cell / Q000473:pathology* / Q000601:surgery; D002681:China; D005260:Female; D006258:Head and Neck Neoplasms / Q000473:pathology* / Q000601:surgery; D006801:Humans; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D012878:Skin Neoplasms / Q000473:pathology* / Q000601:surgery; D013997:Time Factors; D055815:Young Adult