A nanoscale graphene oxide-peptide biosensor for real-time specific biomarker detection on the cell surface.
A nanoscale RGD-pyrene-graphene oxide (GO) biosensor was prepared for real-time in situ detection of a cancer cell surface marker, integrin αvβ3. This nanoscale GO-based biosensor is simple, robust, sensitive and of high selectivity. It can also be adapted to other cancer cell surface marker evaluation systems.
Center for Molecular Imaging and Translational Medicine, School of Public Health, Xiamen University, Xiamen, China 361005.
Zhe
Z
Wang
Peng
P
Huang
Ashwinkumar
A
Bhirde
Albert
A
Jin
Ying
Y
Ma
Gang
G
Niu
Nouri
N
Neamati
Xiaoyuan
X
Chen
D015415:Biomarkers / Q000032:analysis; D015374:Biosensing Techniques; D001943:Breast Neoplasms / Q000737:chemistry* / Q000473:pathology; D006108:Graphite / Q000737:chemistry*; D006801:Humans; D039302:Integrin alphaVbeta3 / Q000032:analysis*; D061986:MCF-7 Cells; D049329:Nanostructures / Q000737:chemistry*; D009842:Oligopeptides / Q000737:chemistry*; D010087:Oxides / Q000737:chemistry*; D011721:Pyrenes / Q000737:chemistry; D013499:Surface Properties; D013997:Time Factors; D014407:Tumor Cells, Cultured
D015415:Biomarkers; D039302:Integrin alphaVbeta3; D009842:Oligopeptides; D010087:Oxides; D011721:Pyrenes; D006108:Graphite; C047981:arginyl-glycyl-aspartic acid; C030984:pyrene