A Weinreb amide approach to the synthesis of trifluoromethylketones.
A novel route to access trifluoromethylketones (TFMKs) from Weinreb amides is reported. This represents the first documented case of the Ruppert-Prakash reagent (TMS-CF(3)) reacting in a constructive manner with an amide and enables synthesis of TMFKs without risk of over-trifluoromethylation.
Department of Chemistry, University of Connecticut, 55 North Eagleville Road, Storrs, CT 06269, USA.
DiAndra M
DM
Rudzinski
Christopher B
CB
Kelly
Nicholas E
NE
Leadbeater
D000577:Amides / Q000737:chemistry*; D007659:Ketones / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D013237:Stereoisomerism
D000577:Amides; D007659:Ketones