[Implants with 32P-foils for LDR-brachytherapy of benign stenosis in urology and gastroenterology].
For LDR-brachytherapy, a limited number of implant geometries and materials are available. To avoid wound healing related hyper-proliferation (stenosis, keloids) a novel radioactive foil system was developed based on beta emitting (32)P, which can be easily integrated in existing implants such as urethral catheters or bile duct stents. As substrate material for these foils PEEK (polyetherethercetone) was chosen because of its radiation hardness during neutron activation of (32)P. The activity was determined by liquid scintillation counting and gamma spectroscopy, dose distributions were measured with scintillation detectors and radiochromic films. The correlation between activity and dose was checked by Monte-Carlo-simulations (Geant4). Prototypes of the (32)P-implants have shown in wash-out tests the required tightness for sealed radioactive sources. In animal tests on urethra and bile duct, the uncomplicated and save application of (32)P-foils mounted on standard implants has been demonstrated, which is almost unchanged due to the simple radiation protection with plexiglass. This concept of radioactive implants with integrated (32)P-foils could extend essentially the application possibilities of LDR-brachytherapy.
Fakultät für Physik, Ludwig-Maximilians-Universität München, Forschungszentrum Garching. walter.assmann@lmu.de
Walter
W
Assmann
Ricarda
R
Becker
Henrike
H
Otto
Markus
M
Bader
Lucas
L
Clemente
Sabine
S
Reinhardt
Claus
C
Schäfer
Jörg
J
Schirra
Stephanie
S
Uschold
Andreas
A
Welzmüller
Ronald
R
Sroka
D001918:Brachytherapy / Q000295:instrumentation* / Q000379:methods*; D003251:Constriction, Pathologic / Q000532:radiotherapy; D004867:Equipment Design; D019544:Equipment Failure Analysis; D005762:Gastroenterology / Q000295:instrumentation*; D006801:Humans; D010761:Phosphorus Radioisotopes / Q000627:therapeutic use*; D019736:Prostheses and Implants; D019275:Radiopharmaceuticals / Q000627:therapeutic use; D014572:Urology / Q000295:instrumentation*
D010761:Phosphorus Radioisotopes; D019275:Radiopharmaceuticals