Protecting the brain during neurosurgical procedures:  strategies that can work.
OBJECTIVE
The quest for neuroprotection strategies during periods of neuronal vulnerability persists despite decades of basic and clinical research. This review will focus on the latest developments in the area of clinical brain protection with the major emphasis on strategies that can be beneficial during neurosurgical procedures.


RESULTS
Brain protection in neurosurgical patients may be achieved by nonpharmacological and pharmacological strategies. Pharmacological neuroprotection including anaesthetic administration have not been recently shown to be successful. Alternatively, nonpharmacological strategies including maintenance of cerebral perfusion by adequate control of mean arterial pressure (≥80 mmHg), liberal normoglycaemia (7.8-10 mmol/l), adequate haemoglobin levels (preoperative ≥120 g/l and intraoperative ≥90 g/l) and induction of hypertension (20-40% of preoperative values) in certain neurosurgical situations can be beneficial as neuroprotectants during neurosurgery. Mild hypothermia (32-35°C) failed to achieve neuroprotective effects in several situations of brain injury.


CONCLUSIONS
The findings of this review suggest that the anaesthesiologist is compelled to use nonpharmacological strategies sometimes based on empiric evidence to protect the brain during neurosurgical procedures. These strategies are simple, have high benefit/risk ratios and are inexpensive. Rigorous controlled clinical studies are needed to investigate the neuroprotective efficacy of these commonly used nonpharmacological methods.
Department of Anaesthesia, Trillium Health Centre, Mississauga, Ontario, Canada. h.el.beheiry@utoronto.ca
Hossam
H
El Beheiry
D000777:Anesthetics / Q000627:therapeutic use; D001786:Blood Glucose / Q000378:metabolism; D001794:Blood Pressure / Q000502:physiology; D001921:Brain / Q000502:physiology*; D001927:Brain Diseases / Q000209:etiology* / Q000517:prevention & control*; D006454:Hemoglobins / Q000378:metabolism; D006801:Humans; D006973:Hypertension / Q000503:physiopathology; D007036:Hypothermia, Induced; D018696:Neuroprotective Agents / Q000627:therapeutic use*; D019635:Neurosurgical Procedures / Q000009:adverse effects*; D011183:Postoperative Complications / Q000517:prevention & control*
D000777:Anesthetics; D001786:Blood Glucose; D006454:Hemoglobins; D018696:Neuroprotective Agents