Nitric oxide delivery by core/shell superparamagnetic nanoparticle vehicles with enhanced biocompatibility.
We report the synthesis of Fe(3)O(4)/silica core/shell nanoparticles and their functionalization with S-nitrosothiols. These nanoparticles are of immense interest because of their nitric oxide (NO) release capabilities in human alveolar epithelial cells. Moreover, they act as large storage reservoirs of NO that can be targeted magnetically to the specific site with a sustainable release of NO for up to 50 h. Such nanoparticles provide an enhancement of the biocompatibility with released NO while allowing intracellular accumulation ascribed to their small size.
National Research Council of Canada, 75 Boulevard de Mortagne, Boucherville, Québec, Canada J4B 6Y4.
X F
XF
Zhang
S
S
Mansouri
D A
DA
Mbeh
L'H
L
Yahia
E
E
Sacher
T
T
Veres
D001672:Biocompatible Materials / Q000737:chemistry* / Q000633:toxicity; D001692:Biological Transport; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D004337:Drug Carriers / Q000737:chemistry* / Q000633:toxicity; D006801:Humans; D058185:Magnetite Nanoparticles / Q000737:chemistry*; D009569:Nitric Oxide / Q000737:chemistry* / Q000378:metabolism*; D010539:Permeability; D026403:S-Nitrosothiols / Q000737:chemistry; D012822:Silicon Dioxide / Q000737:chemistry
D001672:Biocompatible Materials; D004337:Drug Carriers; D058185:Magnetite Nanoparticles; D026403:S-Nitrosothiols; D009569:Nitric Oxide; D012822:Silicon Dioxide