Recurrence risk of preterm birth in subsequent singleton pregnancy after preterm twin delivery.
OBJECTIVE
The purpose of this study was to investigate the recurrence risk of preterm birth (<37 weeks' gestation) in a subsequent singleton pregnancy after a previous nulliparous preterm twin delivery.


METHODS
We included 1957 women who delivered a twin gestation and a subsequent singleton pregnancy from the Netherlands Perinatal Registry. We compared the outcome of subsequent singleton pregnancy of women with a history of preterm delivery to the pregnancy outcome of women with a history of term twin delivery.


RESULTS
Preterm birth in the twin pregnancy occurred in 1075 women (55%) vs 882 women (45%) who delivered at term. The risk of subsequent spontaneous singleton preterm birth was significantly higher after preterm twin delivery (5.2% vs 0.8%; odds ratio, 6.9; 95% confidence interval, 3.1-15.2).


CONCLUSIONS
Women who deliver a twin pregnancy are at greater risk for delivering prematurely in a subsequent singleton pregnancy.
Department of Medical Informatics, Academic Medical Center, Amsterdam, the Netherlands. j.m.schaaf@amc.uva.nl
Jelle M
JM
Schaaf
Michel H P
MH
Hof
Ben Willem J
BW
Mol
Ameen
A
Abu-Hanna
Anita C J
AC
Ravelli
D000328:Adult; D005260:Female; D005865:Gestational Age; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature; D007752:Obstetric Labor, Premature / Q000209:etiology*; D011247:Pregnancy; D059285:Pregnancy, Twin; D047928:Premature Birth / Q000209:etiology*; D012008:Recurrence; D012042:Registries; D012306:Risk