Pseudolaric acid B induces caspase-dependent apoptosis and autophagic cell death in prostate cancer cells.
Previous studies have shown that Pseudolaric acid B (PAB), a medicinal plant-derived terpenoid, is a promising chemopreventive or therapeutic agent against various types of cancer. However, less is known regarding its activity against prostate cancer. The objective of the current study is designed to determine the anti-prostate cancer effects of PAB. We demonstrated here that PAB was highly effective against both androgen-dependent (LNCaP) and androgen-independent prostate cancer cells (PC-3 and DU145) through the mechanisms involved in induction of G2/M cell cycle arrest, caspase-dependent apoptosis and autophagic cell death. Furthermore, PAB can greatly sensitize these two aggressive androgen-independent prostate cancer cells to ABT-737-induced cytotoxicity. Our findings suggest that PAB holds excellent potential as either novel chemopreventive agent or enhancer of therapeutic drug against prostate cancer.
Division of Nutrition and Health, College of Food Science and Nutritional Engineering, China Agricultural University, Haidian District, Beijing, China.
Jing
J
Tong
Shutao
S
Yin
Yinhui
Y
Dong
Xiao
X
Guo
Lihong
L
Fan
Min
M
Ye
Hongbo
H
Hu
D000972:Antineoplastic Agents, Phytogenic / Q000494:pharmacology; D017209:Apoptosis / Q000187:drug effects*; D001343:Autophagy / Q000187:drug effects*; D020169:Caspases / Q000378:metabolism; D059447:Cell Cycle Checkpoints / Q000187:drug effects; D045744:Cell Line, Tumor; D004224:Diterpenes / Q000494:pharmacology*; D006801:Humans; D008297:Male; D011471:Prostatic Neoplasms / Q000378:metabolism*
D000972:Antineoplastic Agents, Phytogenic; D004224:Diterpenes; C058391:pseudolaric acid B; D020169:Caspases