Elevated interleukin-6 concentration and alterations of the coagulation system are associated with the development of intraventricular hemorrhage in extremely preterm infants.
BACKGROUND
Pathogenesis of intraventricular hemorrhage (IVH) in premature infants is multifactorial. Little is known about the influence of pro-inflammatory cytokine activation on the coagulation system in extremely preterm infants and its impact on the development of IVH.


OBJECTIVE
To determine the interaction between serum interleukin-6 (IL-6) and the coagulation system in preterm infants predisposed to the development of IVH.


METHODS
Vitamin K-dependent coagulation factors were examined retrospectively in 132 extremely preterm infants prior to vitamin K administration at the first day of life. Patients were grouped according to the occurrence of IVH and serum concentration of IL-6 >/<100 pg/ml.


RESULTS
Occurrence of IVH was associated with clinical diagnosis of chorioamnionitis, low gestational age, high CRIB score, air leak, catecholamine treatment, low initial hematocrit and increased serum concentration of IL-6. Infants developing IVH showed a diminished coagulation profile. Multivariable logistic regression analysis revealed decreased activity of coagulation factor VII, development of pneumothorax and low hematocrit as independent risk factors for the development of IVH. An increased IL-6 serum concentration was associated with a significantly decreased activity of coagulation factor VII and increased levels of fibrinogen.


CONCLUSIONS
The association of elevated IL-6 levels with alterations of the coagulation profile and development of IVH found in our study supports the assumption of a close pathophysiological relation between inflammation and IVH.
Department of Neonatology, University of Bonn, Bonn, Germany. christine.poralla@ukb.uni-bonn.de
Christine
C
Poralla
Hans-Jörg
HJ
Hertfelder
Johannes
J
Oldenburg
Andreas
A
Müller
Peter
P
Bartmann
Axel
A
Heep
D000328:Adult; D015415:Biomarkers / Q000097:blood; D001778:Blood Coagulation Disorders / Q000097:blood* / Q000175:diagnosis / Q000453:epidemiology; D001779:Blood Coagulation Factors / Q000032:analysis*; D002543:Cerebral Hemorrhage / Q000097:blood* / Q000175:diagnosis / Q000453:epidemiology; D002821:Chorioamnionitis / Q000097:blood / Q000175:diagnosis / Q000453:epidemiology; D015897:Comorbidity; D005167:Factor VII / Q000032:analysis; D005260:Female; D005340:Fibrinogen / Q000032:analysis; D005858:Germany / Q000453:epidemiology; D006400:Hematocrit; D006801:Humans; D062071:Infant, Extremely Premature; D007231:Infant, Newborn; D015850:Interleukin-6 / Q000097:blood*; D008297:Male; D011030:Pneumothorax; D011247:Pregnancy; D012189:Retrospective Studies; D012307:Risk Factors
D015415:Biomarkers; D001779:Blood Coagulation Factors; C508600:IL6 protein, human; D015850:Interleukin-6; D005167:Factor VII; D005340:Fibrinogen