Rheumatology and oncology: an updated review of rheumatic manifestations of malignancy and anti-neoplastictherapy.
OBJECTIVE
Review of the literature addressing the rheumatic manifestations of various malignancies as well as of common chemotherapeutic agents.


METHODS
A literature search was performed to identify key articles regarding the association of rheumatic disease with malignancy.


RESULTS
Our review focused on the association of rheumatic disease with malignancy, paraneoplastic syndromes with rheumatic manifestations, and chemotherapeutic agents related to rheumatic syndromes. We have discussed the importance of a newly described autoantibody that may identify patients at risk for malignancy associated myositis.


CONCLUSIONS
Based on our literature review, recommendations are suggested regarding who and how patients should be screened for malignancy when presenting with various rheumatic symptoms.
Department of Rheumatology, University of South Florida, Tampa, Florida 33612, USA.
Abie
A
Alias
Ernesto J
EJ
Rodriguez
Helen E
HE
Bateman
Ashley G
AG
Sterrett
Joanne
J
Valeriano-Marcet
D000970:Antineoplastic Agents / Q000009:adverse effects*; D001323:Autoantibodies / Q000097:blood; D015415:Biomarkers / Q000097:blood; D006801:Humans; D009369:Neoplasms / Q000150:complications* / Q000188:drug therapy*; D010257:Paraneoplastic Syndromes / Q000139:chemically induced / Q000209:etiology* / Q000276:immunology; D012216:Rheumatic Diseases / Q000139:chemically induced / Q000209:etiology* / Q000276:immunology; D018570:Risk Assessment; D012307:Risk Factors
D000970:Antineoplastic Agents; D001323:Autoantibodies; D015415:Biomarkers