Skin permeation of cacalol, cacalone and 6-epi-cacalone sesquiterpenes from a nanoemulsion.
The objective of the present study was to investigate the transdermal permeation of cacalol (1) and a mixture of cacalone (2) and 6-epi-cacalone (3) in comparison with diclofenac acid (4) delivered from the same characterized nanoemulsion using Franz diffusion cells (formulae I, II and III). Results show that de Kp, J, Q24, PI and P2 were higher for the acid diclofenac nanoemulsion than for the natural products nanoemulsions. As for the differences between the formulations I and II, with the natural products, Q24, the quantity extracted from skin and P2 were higher in the mixture of 2 and 3 nanoemulsion compared with the corresponding nanoemulsion of 1. In conclusion, the low permeability of the natural products nanoemulsions in comparison with that of diclofenac acid has the potential for development for drugs with local and systemic applications, respectively.
Centro de Investigaciones Químicas, Universidad Autónoma del Estado de Morelos, Cuernavaca, Morelos 62209, México. Igarduno@uaem.mx
María Luisa
ML
Garduño-Ramírez
Beatriz
B
Clares
Valeri
V
Domínguez-Villegas
Concepción
C
Peraire
María Adolfina
MA
Ruiz
María Luisa
ML
García
Ana C
AC
Calpena
D000279:Administration, Cutaneous; D000818:Animals; D004655:Emulsions; D006801:Humans; D012717:Sesquiterpenes / Q000737:chemistry / Q000493:pharmacokinetics*; D012869:Skin Absorption / Q000502:physiology
D004655:Emulsions; D012717:Sesquiterpenes; C497192:cacalol; C515649:cacalone