Systemic IgG4-related sclerosing disease: spectrum of imaging findings and differential diagnosis.
OBJECTIVE
The purposes of this article are to provide a practical review of the spectrum of imaging findings in patients with systemic IgG4-related sclerosing disease and to address the differential diagnoses.


CONCLUSIONS
IgG4-related sclerosing disease is a systemic disorder that can involve almost any organ. The imaging findings consist of diffuse and focal organ infiltration and encasement by inflammatory and fibrotic tissue. Awareness of the spectrum of imaging findings in IgG4-related disease should prompt further evaluation for systemic manifestations to avoid misdiagnosis.
Department of Diagnostic Radiology, Eberhard-Karls-University, Tübingen, Germany. marius.horger@med.uni-tuebingen.de
Marius
M
Horger
Hans-Georg
HG
Lamprecht
Roland
R
Bares
Daniel
D
Spira
Marc
M
Schmalzing
Claus Detlef
CD
Claussen
Patrick
P
Adam
D000368:Aged; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000032:analysis*; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D049268:Positron-Emission Tomography; D012595:Scleroderma, Systemic / Q000150:complications / Q000175:diagnosis* / Q000276:immunology; D014057:Tomography, X-Ray Computed
D007074:Immunoglobulin G