Impact of Duffy antigen receptor for chemokine gene expression on mandibular bone density in menopausal women.
The aim of this study is to demonstrate the relationship between the expression of the Duffy antigen receptor for chemokine (DARC) gene in peripheral blood leucocytes and epithelial cells of the oral cavity and the level of bone mineral density (BMD) in the mandible of women during menopause. A special radiographic method for measuring mandible density was used. Studies of DARC gene expression in the epithelial cells of the oral cavity and peripheral blood leucocytes did not confirm a significant correlation between expression of DARC and the level of BMD of the mandible in patients from the study groups, both in assessing the level of gene expression (ΔC(T) DARC) in the epithelium and leucocytes, as well as the value of relative expression (RQ) of DARC epithelium and lymphocytes. Significant differences were found between the values of ΔC(T) DARC marked in leucocytes and the epithelium of the control and study groups. Regarding RQ, the tests showed no significant differences between the values marked in the epithelial cells and leucocytes. The influence of DARC gene expression on bone mineral density of the mandible was not confirmed.
Department of Oral Surgery, Medical University of Lublin, Lublin, Poland. wswiatkowski@hot.pl
W
W
Świątkowski
M
M
Rahnama
J
J
Kocki
A
A
Światkowską
D000328:Adult; D000368:Aged; D000375:Aging / Q000378:metabolism*; D015519:Bone Density / Q000235:genetics / Q000502:physiology*; D016022:Case-Control Studies; D004375:Duffy Blood-Group System / Q000235:genetics / Q000378:metabolism*; D004848:Epithelium / Q000378:metabolism; D005260:Female; D015870:Gene Expression; D006801:Humans; D007962:Leukocytes / Q000378:metabolism; D008334:Mandible / Q000000981:diagnostic imaging / Q000378:metabolism*; D008593:Menopause / Q000378:metabolism*; D008875:Middle Aged; D011859:Radiography; D011956:Receptors, Cell Surface / Q000235:genetics / Q000378:metabolism*; D012016:Reference Values; D055815:Young Adult
C473745:ACKR1 protein, human; D004375:Duffy Blood-Group System; D011956:Receptors, Cell Surface