Reversible thermal transition of polydiacetylene based on KTTKS collagen sequence.
Here we explore the physico-chemical properties of a peptide amphiphile obtained by chemical conjugation of the collagen-stimulating peptide KTTKS with 10,12-pentacosadiynoic acid which photopolymerizes as a stable and extended polydiacetylene. We investigate the self-assembly of this new polymer and rationalize its peculiar behavior in terms of a thermal conformational transition. Surprisingly, this polymer shows a thermal transition associated with a non-cooperative increase in β-sheet content at high temperature.
School of Chemistry, Food and Pharmacy, University of Reading, Reading RG6 6AD, UK.
Pasquale
P
Palladino
Valeria
V
Castelletto
Ashkan
A
Dehsorkhi
Dmitry
D
Stetsenko
Ian W
IW
Hamley
D003094:Collagen / Q000737:chemistry; D015394:Molecular Structure; D009842:Oligopeptides / Q000737:chemistry*; D055668:Photochemical Processes; D000078789:Polyacetylene Polymer; D058105:Polymerization; D011108:Polymers / Q000138:chemical synthesis / Q000737:chemistry*; D053279:Polyynes / Q000138:chemical synthesis / Q000737:chemistry*; D013696:Temperature
D009842:Oligopeptides; D000078789:Polyacetylene Polymer; D011108:Polymers; D053279:Polyynes; C082361:polydiacetylene; D003094:Collagen