[Thyroid differenciated carcinoma in children. Study from Normandy].
OBJECTIVE
Definition of a strategy for the management of thyroid differenciated carcinoma in children.


METHODS
Retrospective cohort study from the Normandy area in France.


METHODS
Analysis of the medical records of 13 children and adolescents (age > 15 years), presenting with thyroid differenciated carcinoma in three Normandy French hospitals from 1994 to 2006, to determine the clinical features and treatment of the disease.


RESULTS
X of the patients were male and y were female, with a mean age at presentation of 11 years. Most frequently symptom was solitary nodes in the thyroid gland (69%). Most frequent histological type was papillary cancer (92%). Size of tumor was > 4 cm in 23% of cases. Children had undergone surgery with total thyroidectomy, radio-iodine treatment and suppressive hormonotherapy. We observed 46% post surgery complications. All patients were alive and none developed a recurrence.


CONCLUSIONS
Thyroid differenciated carcinoma in children and adolescents were more agressif with most frequently metastasis and recurrence than thyroid differenciated carcinoma of adults. Pronostic is good with 90% of survival at 20 years. We propose a coherent plan of treatment: 1. Thyroidectomy with cervical central lymph node dissection (group VI) completed bilateral selected head neck dissection compartments (groups IIa, III, IV) if macroscopic lymph node metastases in lateral cervical compartment. 2. Postoperative radioiodine is done in all tumor > T1N0 and completed with hormonotherapy.
CHU Caen, Hôpital Côte de Nacre, Service ORL et CCF, av de la Côte de Nacre, 14033 Caen cedex 9, France. d.blanchard@baclesse.fr
D
D
Blanchard
O
O
Choussy
J
J
Rame
A
A
Bequigon
D
D
Dehesdin
D
D
De Raucourt
S
S
Bardet
E
E
Babin
D000293:Adolescent; D002291:Carcinoma, Papillary / Q000453:epidemiology / Q000473:pathology* / Q000628:therapy*; D002648:Child; D015331:Cohort Studies; D005260:Female; D005602:France / Q000453:epidemiology; D006801:Humans; D007457:Iodine Radioisotopes / Q000627:therapeutic use; D008297:Male; D011183:Postoperative Complications; D012189:Retrospective Studies; D013964:Thyroid Neoplasms / Q000453:epidemiology / Q000473:pathology* / Q000628:therapy*; D013965:Thyroidectomy; D013974:Thyroxine / Q000627:therapeutic use
D007457:Iodine Radioisotopes; D013974:Thyroxine