Alternating antipyretics in the treatment of fever in children: a systematic review of randomized clinical trials.
OBJECTIVE
To summarize the existing evidence on the efficacy of therapy with alternating antipyretics compared to monotherapy in the management of fever in children.


METHODS
MEDLINE, EMBASE, Cochrane Library, LILACS, SciELO, IBECS, Web of Science, Clinical Trials, Google Scholar and references of the articles found. The review included randomized clinical trials published until December 2011, in which one of the arms was the alternating antipyretics therapy to treat fever in children younger than 12 years, treated on an outpatient basis. Data selection and extraction were performed independently by two reviewers. The quality of the studies was assessed according to CONSORT items.


RESULTS
The selected studies showed great heterogeneity of participants, temperature for fever diagnosis, interventions (dose and dosing intervals) and assessed outcomes. The treatment groups ranged from 38 to 464 children. The studies compared paracetamol and ibuprofen alternated with paracetamol and/or ibuprofen. Only one study used different doses from the 15 mg/kg for paracetamol and 10 mg/kg for ibuprofen, but the dosing intervals varied considerably. The alternate use with dipyrone or acetylsalicylic acid was not assessed by any of the studies. Overall, the articles pointed to a tendency of lower mean temperatures in groups with alternating therapy. Few adverse effects were reported.


CONCLUSIONS
Although there was a tendency towards the reduction of mean temperatures with alternating antipyretics compared to the use of one antipyretic alone, there is not enough evidence to say that alternating antipyretic therapy is more effective than monotherapy.
Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, RS, Brazil.
Gracian Li
GL
Pereira
Josiane Magda Camarotto
JM
Dagostini
Tatiane da Silva Dal
Tda S
Pizzol
D000082:Acetaminophen / Q000008:administration & dosage*; D058633:Antipyretics / Q000008:administration & dosage*; D002648:Child; D057915:Drug Substitution / Q000379:methods; D004359:Drug Therapy, Combination; D005334:Fever / Q000188:drug therapy*; D006801:Humans; D007052:Ibuprofen / Q000008:administration & dosage*; D016032:Randomized Controlled Trials as Topic; D016896:Treatment Outcome
D058633:Antipyretics; D000082:Acetaminophen; D007052:Ibuprofen