Hepatoprotective iridoid glycosides from the roots of Rehmannia glutinosa.
Eleven new iridoid glycosides, rehmaglutosides A-K (1-11), together with 20 known analogues were isolated from the air-dried roots of Rehmannia glutinosa. The structures of these compounds were elucidated on the basis of spectroscopic data analysis and chemical evidence. Furthermore, in in vitro assays, compounds 3, 7, and 9-11 (10 μM) exhibited moderate hepatoprotective activities against D-galactosamine-induced HL-7702 cell damage.
State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, People's Republic of China.
Yan-Fei
YF
Liu
Dong
D
Liang
Huan
H
Luo
Zhi-You
ZY
Hao
Yan
Y
Wang
Chun-Lei
CL
Zhang
Qing-Jian
QJ
Zhang
Ruo-Yun
RY
Chen
De-Quan
DQ
Yu
D005688:Galactosamine / Q000737:chemistry / Q000494:pharmacology; D006027:Glycosides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D022781:Hepatocytes / Q000187:drug effects*; D006801:Humans; D057889:Iridoid Glycosides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D018517:Plant Roots / Q000737:chemistry; D032267:Rehmannia / Q000737:chemistry*
D006027:Glycosides; D057889:Iridoid Glycosides; C576967:rehmaglutoside A; D005688:Galactosamine