Archaeal orc1/cdc6 proteins.
The initiation of DNA replication in most archaeal genomes is mediated by proteins related to eukaryotic Orc1 and Cdc6. Archaeal replication origins have been mapped and their interactions with Orc1/Cdc6 proteins have been characterized at the biochemical level. Structural and biophysical studies have revealed the basic rules of sequence recognition by archaeal initiators.
Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford, OX1 3RE, UK, stephen.bell@path.ox.ac.uk.
Stephen D
SD
Bell
D001105:Archaea / Q000502:physiology*; D019843:Archaeal Proteins / Q000235:genetics / Q000378:metabolism; D018797:Cell Cycle Proteins / Q000235:genetics / Q000378:metabolism; D004261:DNA Replication / Q000502:physiology*; D019641:DNA, Archaeal / Q000096:biosynthesis / Q000235:genetics; D004268:DNA-Binding Proteins / Q000235:genetics / Q000378:metabolism
D019843:Archaeal Proteins; D018797:Cell Cycle Proteins; D019641:DNA, Archaeal; D004268:DNA-Binding Proteins