[Progress on hydrolases-targeting antiparasitic prodrugs].
Prodrug strategies have been used for drug optimization to overcome the drawbacks in pharmaceutics, pharmacokinetics and pharmacodynamics. Most enzymes involved in prodrug biotransformation are hydrolases, in which esterase and amidase have been widely researched. This review summarizes the recent progress in antiparasitic prodrugs based on both targets.
National Institute of Parasitic Diseases, Chinese Center for Disease Control and Prevention, Shanghai 200025, China.
Ai-Dan
AD
Wen
Hao-Bing
HB
Zhang
D000977:Antiparasitic Agents / Q000737:chemistry / Q000494:pharmacology; D015195:Drug Design; D006867:Hydrolases / Q000737:chemistry / Q000494:pharmacology; D011355:Prodrugs / Q000737:chemistry / Q000493:pharmacokinetics
D000977:Antiparasitic Agents; D011355:Prodrugs; D006867:Hydrolases