Atypical pituitary adenoma with neurocytic transformation.
Here, we report an example of an atypical prolactin-producing pituitary adenoma showing clear morphologic and immunohistochemical evidence of neurocytic transformation. Its features support the concept that neoplastic neuroendocrine cells, in this case adenohypophyseal cells, are capable of neuronal differentiation and broaden the morphologic spectrum of such rare tumors. Our findings have implications with respect to the nosology of neuronal tumors of the adenohypophysis.
*Department of Laboratory Medicine and Pathology, St. Michael's Hospital, University of Toronto, Toronto, ON, Canada †Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN ‡Departments of Pathology §Neurosurgery, Methodist Children's Hospital of South Texas, San Antonio, TX ∥Department of Pathology, Acibadem Medical Center, Istanbul, Turkey.
Fabio
F
Rotondo
Marie Christine F
MC
Bernardo
Bernd W
BW
Scheithauer
Shahnila
S
Latif
Christopher
C
Bogaev
Aydin
A
Sav
Kalman
K
Kovacs
D000236:Adenoma / Q000175:diagnosis* / Q000473:pathology; D000328:Adult; D005260:Female; D006801:Humans; D010911:Pituitary Neoplasms / Q000175:diagnosis* / Q000473:pathology; D055815:Young Adult