Hypomagnesemia associated with a proton pump inhibitor.
Severe hypomagnesemia is a serious clinical condition. Proton pump inhibitor (PPI) induced hypomagnesemia has been recognized since 2006. In March 2011 the U.S. Food and Drug Administration advised that long-term use of PPI can induce hypomagnesemia. We report the first Japanese case of hypomagnesemia associated with chronic use of PPIs in a 64-year-old man hospitalized for nausea, bilateral ankle arthritis, and tremor of the extremities who had convulsions 3 days after admission. Blood analysis showed severe hypomagnesemia. He had been taking rabeprazole (10 mg/day) for 5 years. After stopping rabeprazole and correcting the electrolytes imbalances, his symptoms improved without recurrence.
Department of Gastroenterology, Ishikawa Prefectural Central Hospital, Japan.
Jun
J
Matsuyama
Kunihiro
K
Tsuji
Hisashi
H
Doyama
Fae
F
Kim
Yasuhito
Y
Takeda
Yosuke
Y
Kito
Renma
R
Ito
Hiroyoshi
H
Nakanishi
Tomoyuki
T
Hayashi
Yohei
Y
Waseda
Shigetsugu
S
Tsuji
Kenichi
K
Takemura
Shinya
S
Yamada
Toshihide
T
Okada
Honin
H
Kanaya
D053799:2-Pyridinylmethylsulfinylbenzimidazoles / Q000009:adverse effects* / Q000627:therapeutic use; D005764:Gastroesophageal Reflux / Q000139:chemically induced; D006801:Humans; D008274:Magnesium / Q000097:blood*; D008275:Magnesium Deficiency / Q000139:chemically induced; D008297:Male; D008875:Middle Aged; D054328:Proton Pump Inhibitors / Q000009:adverse effects* / Q000627:therapeutic use; D064750:Rabeprazole
D053799:2-Pyridinylmethylsulfinylbenzimidazoles; D054328:Proton Pump Inhibitors; D064750:Rabeprazole; D008274:Magnesium