p62 Stages an interplay between the ubiquitin-proteasome system and autophagy in the heart of defense against proteotoxic stress.
As exemplified by desmin-related cardiomyopathy and myocardial ischemia/reperfusion injury, proteasome functional insufficiency plays an essential pathogenic role in the progression of cardiac diseases with elevated proteotoxic stress. Upregulation of p62/SQSTM1 and increased selective autophagy in cardiomyocytes may protect against proteotoxic stress in the heart. p62 may serve as a proteotoxic stress sensor, promote segregation and degradation of misfolded proteins by autophagy, and mediate the cross talk between the ubiquitin-proteasome system and autophagy.
Protein Quality Control and Degradation Research Center and Division of Basic Biomedical Sciences, Sanford School of Medicine of the University of South Dakota, Vermillion, SD 57069, USA.
Huabo
H
Su
Xuejun
X
Wang
D048868:Adaptor Proteins, Signal Transducing / Q000378:metabolism*; D000818:Animals; D001343:Autophagy; D006331:Heart Diseases / Q000201:enzymology* / Q000473:pathology; D006801:Humans; D009206:Myocardium / Q000201:enzymology* / Q000473:pathology; D046988:Proteasome Endopeptidase Complex / Q000378:metabolism*; D017510:Protein Folding; D057165:Proteostasis Deficiencies / Q000201:enzymology* / Q000473:pathology; D000071456:Sequestosome-1 Protein; D015398:Signal Transduction; D013312:Stress, Physiological; D025801:Ubiquitin / Q000378:metabolism*; D015854:Up-Regulation
D048868:Adaptor Proteins, Signal Transducing; C099718:SQSTM1 protein, human; D000071456:Sequestosome-1 Protein; D025801:Ubiquitin; D046988:Proteasome Endopeptidase Complex