Small intestinal transplant mucosal necrosis associated with enteral sodium polystyrene sulfonate administration.
Diarrhea is a common manifestation of disease in recipients of intestinal transplants. Sodium Polystyrene Sulfonate administration has been associated with significant bowel injury. Recognizing the diagnosis requires clinical awareness and comprehensive review of intestinal biopsies. We present an illustrative case and discussion. It is the first reported case in a pediatric intestinal transplant patient with serial intestinal biopsies documenting the evolution of disease.
Division of Pediatric GI & Nutrition, University of Alberta, Alberta, Canada.
M
M
Saginur
A
A
Thiesen
A
A
Lacson
D
D
Bigam
J
J
Yap
D001707:Biopsy, Needle; D002675:Child, Preschool; D003967:Diarrhea / Q000175:diagnosis / Q000209:etiology; D004636:Emergency Service, Hospital; D005500:Follow-Up Studies; D006801:Humans; D007081:Ileostomy / Q000009:adverse effects / Q000379:methods; D007082:Ileum / Q000473:pathology / Q000637:transplantation*; D007150:Immunohistochemistry; D007413:Intestinal Mucosa / Q000187:drug effects / Q000473:pathology*; D008297:Male; D009336:Necrosis / Q000139:chemically induced / Q000473:pathology; D016377:Organ Transplantation / Q000009:adverse effects* / Q000379:methods; D011137:Polystyrenes / Q000008:administration & dosage* / Q000009:adverse effects*; D018570:Risk Assessment
D011137:Polystyrenes; C003321:polystyrene sulfonic acid