An efficient and convenient palladium catalyst system for the synthesis of amines from allylic alcohols.
A novel catalyst system for efficient amination of allylic alcohols with aryl and alkyl amines is presented. By applying a convenient combination consisting of Pd(OAc)(2)/1,10-phenanthroline, a variety of allylic alcohols reacted smoothly to give the corresponding secondary and tertiary amines in good to excellent yields with high regioselectivity. The usefulness of our protocol is demonstrated in the one-step synthesis of the antifungal drug naftifine and the calcium channel blocker flunarizine.
Leibniz-Institut für Katalyse e. V. an der Universität Rostock, Albert-Einstein-Strasse 29a, 18059 Rostock, Germany.
Debasis
D
Banerjee
Rajenahally V
RV
Jagadeesh
Kathrin
K
Junge
Henrik
H
Junge
Matthias
M
Beller
D000588:Amines / Q000138:chemical synthesis* / Q000737:chemistry; D002384:Catalysis; D060326:Chemistry Techniques, Synthetic; D009942:Organometallic Compounds / Q000737:chemistry; D010165:Palladium / Q000737:chemistry*; D010618:Phenanthrolines / Q000737:chemistry; D020005:Propanols / Q000737:chemistry*
D000588:Amines; D009942:Organometallic Compounds; D010618:Phenanthrolines; D020005:Propanols; C006463:allyl alcohol; D010165:Palladium; C025205:1,10-phenanthroline