Graphene oxide, but not fullerenes, targets immunoproteasomes and suppresses antigen presentation by dendritic cells.
Graphene oxide (GO) and C60 - or C60 -TRIS fullerenes, internalized by murine dendritic cells (DCs), differently affect their abilities to present antigens to T-cells. While C60 -fullerenes stimulate the ovalbumin-specific MHC class I-restricted T-cell response, GO impairs the stimulatory potential of DCs. In contrast to C60 -fullerenes, GO decreases the intracellular levels of LMP7 immunoproteasome subunits required for processing of protein antigens. This is important for the development of DC-based vaccines.
Health Effects Laboratory Division, NIOSH, 1095 Willowdale Road, Morgantown, WV 26505, USA.
Alexey V
AV
Tkach
Naveena
N
Yanamala
Shyla
S
Stanley
Michael R
MR
Shurin
Galina V
GV
Shurin
Elena R
ER
Kisin
Ashley R
AR
Murray
Samantha
S
Pareso
Timur
T
Khaliullin
Gregg P
GP
Kotchey
Vincent
V
Castranova
Sanjay
S
Mathur
Bengt
B
Fadeel
Alexander
A
Star
Valerian E
VE
Kagan
Anna A
AA
Shvedova
D000818:Animals; D017951:Antigen Presentation / Q000187:drug effects*; D003713:Dendritic Cells / Q000187:drug effects* / Q000276:immunology; D037741:Fullerenes / Q000494:pharmacology*; D006108:Graphite / Q000737:chemistry / Q000494:pharmacology*; D051379:Mice; D010087:Oxides / Q000494:pharmacology; D046988:Proteasome Endopeptidase Complex / Q000187:drug effects*
D037741:Fullerenes; D010087:Oxides; D006108:Graphite; D046988:Proteasome Endopeptidase Complex