Concurrent hepatic adenomatoid tumor and hepatic hemangioma: a case report.
A 45-year-old male with alleged asymptomatic hepatic hemangioma of 4 years duration had right upper-quadrant pain and was referred to a tertiary hospital. Computed tomography and magnetic resonance imaging scans revealed a hypervascular mass of about 7 cm containing intratumoral multilobulated cysts. A preoperative liver biopsy was performed, but this failed to provide a definitive diagnosis. The patient underwent a partial hepatectomy of segments IV and VIII. The histologic findings revealed multifocal proliferation of flattened or cuboidal epithelioid cells and a highly vascular edematous stroma. Immunohistochemistry findings demonstrated that the epithelioid tumor cells were positive for cytokeratin (AE1/AE3), vimentin, calretinin, and cytokeratin 5/6, and were focally positive for CD10, and negative for WT1 and CD34, all of which support their mesothelial origin. Immunohistochemistry for a mesothelial marker should be performed for determining the presence of an adenomatoid tumor when benign epithelioid cells are seen.
Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
Ji-Beom
JB
Kim
Eunsil
E
Yu
Ju-Hyun
JH
Shim
Gi-Won
GW
Song
Gwang Un
GU
Kim
Young-Joo
YJ
Jin
Ho-Seop
HS
Park
D018254:Adenomatoid Tumor / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery; D064032:Calbindin 2; D006391:Hemangioma / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery; D006498:Hepatectomy; D006801:Humans; D007633:Keratins / Q000378:metabolism; D008113:Liver Neoplasms / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D015260:Neprilysin / Q000378:metabolism; D064030:S100 Calcium Binding Protein G / Q000378:metabolism; D014057:Tomography, X-Ray Computed; D014746:Vimentin / Q000378:metabolism
C576764:CALB2 protein, human; D064032:Calbindin 2; D064030:S100 Calcium Binding Protein G; D014746:Vimentin; D007633:Keratins; D015260:Neprilysin