Can animal skin diseases or current transgenic mice serve as a model for hidradenitis suppurativa?
The pathogenesis of hidradenitis suppurativa (HS) is still enigmatic, and a valid animal model for HS is currently not available. The recent discovery of γ-secretase mutations in a subpopulation of patients with HS suggested γ-secretase transgenic mice as a model for HS pathogenesis. However, the discrepancies between human HS and these mice are daunting. We critically review cases of animal HS and transgenic γ-secretase mouse models for HS and discuss the criteria which should be met for a representative pathogenic model.
Department of Dermatology, Erasmus University Medical Center, Rotterdam, The Netherlands. h.vanderzee@erasmusmc.nl
H H
HH
van der Zee
J D
JD
Laman
E P
EP
Prens
D053829:Amyloid Precursor Protein Secretases / Q000235:genetics* / Q000378:metabolism; D000818:Animals; D004195:Disease Models, Animal; D017497:Hidradenitis Suppurativa / Q000209:etiology* / Q000473:pathology; D006801:Humans; D051379:Mice; D008822:Mice, Transgenic
D053829:Amyloid Precursor Protein Secretases