The association of interleukin 6-634C/G polymorphism with left atrial thrombus and severe spontaneous echocontrast in patients with atrial fibrillation.
Atrial fibrillation (AF) not only is an independent risk factor for death but also confers significant risk of morbidity from stroke associated with left atrial thrombus. The association of interleukin 6 (IL-6) polymorphism with thrombus in AF has not been investigated before. We carried out a case-control study in Han Chinese. The IL-6 -634C/G genotypes of 31 patients with thrombus and 45 patients without thrombus were detected by polymerase chain reaction and restriction fragment length polymorphism. The frequencies of the IL-6 genotypes (CC, CG, and GG) were 29.03%, 54.54%, and 16.13% for the patients with thrombus, and 55.56%, 40.00%, and 4.44% for the patients without thrombus, respectively (P = .0391). Compared with the CC genotype, the G allele carriers (CG + GG) had a 2.79-fold increased risk of thrombus or severe spontaneous echocontrast (SEC). These results suggest that IL-6 -634C/G polymorphism is associated with thrombus and severe SEC, and the G allele is an independent risk for thrombus and severe SEC in Han Chinese patients with AF.
1Department of Cardiology, Xinghua People's Hospital, Xinghua, China.
Xin-Tao
XT
Deng
Min-Hui
MH
Jiang
Jian-Hua
JH
Zhu
Li-Jun
LJ
Ge
Jing
J
Guo
Shu-Ping
SP
Gao
Jin-Guo
JG
Zheng
Hong
H
Luan
Gui-Liang
GL
Shi
Ru-Xing
RX
Wang
Hai-Feng
HF
Shi
Min
M
Pan
D001281:Atrial Fibrillation / Q000097:blood* / Q000000981:diagnostic imaging / Q000235:genetics*; D016022:Case-Control Studies; D003430:Cross-Sectional Studies; D017548:Echocardiography, Transesophageal; D005260:Female; D005838:Genotype; D006801:Humans; D015850:Interleukin-6 / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors; D013927:Thrombosis / Q000097:blood* / Q000000981:diagnostic imaging / Q000235:genetics*
D015850:Interleukin-6