[Pulmonary fibrosis associated with anti-neutrophil cytoplasmic antibody positive vasculitis].
The most frequently observed pulmonary complications of vasculitis (AAV) with anti-neutrophil cytoplasmic positive antibodies (ANCA) are alveolar hemorrhage, granulomas and airway stenosis. In recent years, some reports have been published that show the association of vasculitis with pulmonary fibrosis (PF), suggesting that it may be another complication of AAV. We report and describe here two cases with such association, and their clinical, tomographic and immunological characteristics. Given that in the association between PF and AAV, as reported in the last years, PF could be the first manifestation of AAV, the search for ANCA in patients with PF may be necessary, as a cause of it and for the possible subsequent development of vasculitis.
Sección Neumonología, Hospital Profesor Alejandro Posadas, Haedo, Buenos Aires, Argentina. mfercasar@intramed.net
Marcelo
M
Fernández Casares
Alejandra
A
González
Flavia
F
Caputo
Yanina
Y
Bottinelli
Patricia
P
Nastavi
Marcelo
M
Zamboni
D000368:Aged; D056648:Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis / Q000150:complications*; D019268:Antibodies, Antineutrophil Cytoplasmic / Q000097:blood; D017809:Fatal Outcome; D006801:Humans; D008297:Male; D055953:Microscopic Polyangiitis / Q000150:complications; D008875:Middle Aged; D011658:Pulmonary Fibrosis / Q000150:complications*
D019268:Antibodies, Antineutrophil Cytoplasmic