Treatment of smell loss with systemic methylprednisolone.
Olfactory dysfunction is a common complaint in a large number of people. As the aetiologies of olfactory  dysfunction vary greatly so do the treatment approaches. The aim of this retrospective study was to evaluate treatment with systemic corticosteroids, particularly focusing on its effectiveness on the different olfactory dysfunction aetiologies. Although a prospective randomized control trail is preferred for such an investigation, using the current approach, we were able to test a very large patient population.



A total of 425 patients with olfactory dysfunction were treated with systemic corticosteroids for 14 days. Olfactory performance was measured using the `Sniffin` Sticks` battery before and after the treatment.



The treatment with systemic corticosteroids significantly increased the performance on the TDI score and on each of the three subtests; threshold, discrimination and identification. In 26.6% of the patients improvement of more than six points of the TDI score was observed. The treatment proved to be more effective in patients with sinunasal olfactory dysfunction, where this percentage increased to 36.7, compared to other aetiologies. In addition, the increase in olfactory function was negatively correlated with the TDI score before the treatment.



This study confirms the effectiveness of systemic corticosteroids on olfactory dysfunction in a large patient population. Specifically, the results show that treatment is: (a) more effective in patients with sinunasal than in patients with idiopathic olfactory dysfunction, (b) most effective in patients with sinunasal disease with nasal polyps, and (c), at best, effective in half of the patients. The current study may provide help in counselling patients.
Department of Otorhinolaryngology, University of Dresden Medical School, Dresden, Germany.
V A
VA
Schriever
C
C
Merkonidis
N
N
Gupta
C
C
Hummel
T
T
Hummel
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D004334:Drug Administration Schedule; D005260:Female; D005938:Glucocorticoids / Q000008:administration & dosage*; D006801:Humans; D008297:Male; D008775:Methylprednisolone / Q000008:administration & dosage*; D008875:Middle Aged; D000857:Olfaction Disorders / Q000188:drug therapy* / Q000209:etiology / Q000503:physiopathology; D055696:Olfactory Perception / Q000502:physiology; D012189:Retrospective Studies; D012684:Sensory Thresholds / Q000502:physiology; D016896:Treatment Outcome; D055815:Young Adult
D005938:Glucocorticoids; D008775:Methylprednisolone