Evaluation of two hepatitis C virus genotyping assays based on the 5' untranslated region (UTR): the limitations of 5' UTR-based assays and the need for a supplementary sequencing-based approach.
We evaluated two genotyping methodologies that characterize the 5' untranslated region (5' UTR) of the hepatitis C virus (HCV) genome. The limitations of these genotype assays need to be thoroughly evaluated, and sequencing-based approaches may be needed to complement these methods in clinical settings.
Department of Laboratory Medicine, College of Medicine, Seoul National University Hospital, Seoul, South Korea.
Sung Kuk
SK
Hong
Sung Im
SI
Cho
Eun Kyung
EK
Ra
Eui-Chong
EC
Kim
Joon Sung
JS
Park
Sung Sup
SS
Park
Moon-Woo
MW
Seong
D020121:5' Untranslated Regions; D016174:Hepacivirus / Q000145:classification* / Q000235:genetics*; D006801:Humans; D058889:Molecular Typing / Q000379:methods*; D014773:Virology / Q000379:methods*
D020121:5' Untranslated Regions