The lymphotoxin-α 252A>G polymorphism and breast cancer: a meta-analysis.
OBJECTIVE
The aim of this meta-analysis is to evaluate associations between LTA-252 A>G and breast cancer (BC).


METHODS
Electronic searches of several databases were conducted for all online publications. A total of 7 studies involving 4,625 BC patients and 4,373 controls were identified.


RESULTS
This meta-analysis showed no significant association between the LTA-252 A>G polymorphism and BC in overall or Caucasian populations. However, a positive association was found limited to Asian populations.


CONCLUSIONS
Although there was no significant association found between the LTA-252 A>G polymorphism and BC overall, a positive association was found in Asian populations.
Department of General Surgery, the Third Affiliated Hospital to Nantong University, Wuxi, China.
Ping
P
Zhou
Wei
W
Huang
Xing
X
Chu
Liang-Feng
LF
Du
Jian-Ping
JP
Li
Chun
C
Zhang
D001943:Breast Neoplasms / Q000235:genetics*; D016022:Case-Control Studies; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D008233:Lymphotoxin-alpha / Q000235:genetics*; D011110:Polymorphism, Genetic / Q000235:genetics*; D011379:Prognosis
D008233:Lymphotoxin-alpha