Desymmetrisation of aromatic diamines and synthesis of non-symmetrical thiourea derivatives by click-mechanochemistry.
ortho- and para-Phenylenediamines were desymmetrised and quantitatively transformed into mono- and bis-(thio)ureas or mixed thiourea-ureas through a one-pot mechanochemical click reaction sequence; mechanochemical desymmetrisation proceeds quantitatively without excess reagents and allows the controlled extension of a molecular structure by combining normally competing reactions.
Ruđer Bošković Institute, Bijenička cesta 54, HR-10002 Zagreb, Croatia.
Vjekoslav
V
Štrukil
Davor
D
Margetić
Marina D
MD
Igrc
Mirjana
M
Eckert-Maksić
Tomislav
T
Friščić
D057930:Click Chemistry; D015394:Molecular Structure; D010655:Phenylenediamines / Q000737:chemistry*; D013237:Stereoisomerism; D013890:Thiourea / Q000138:chemical synthesis* / Q000737:chemistry
D010655:Phenylenediamines; D013890:Thiourea