An elderly patient with chronic active Epstein-Barr virus infection with mixed cryoglobulinemia and review of the literature.
A 76-year-old woman was diagnosed with chronic active Epstein-Barr virus (EBV) infection (CAEBV) with sustained fever, anemia, numbness of the lower limbs, and liver dysfunction. The patient had an unusual anti-EBV antibody profile and high viral load, positive rheumatoid factor, and cryoglobulinemia. She suffered from recurrent hemosputum with pleural effusion and thrombocytopenia caused by CAEBV infection, and she died in July 2008. Here, we present a rare case of CAEBV infection with cryoglobulinemia in an elderly patient.
Department of Rheumatology, Unit of Translational Medicine, Graduate School of Biomedical Sciences, Nagasaki University, 1-7-1 Sakamoto, Nagasaki, 852-8501, Japan, kichinos@nagasaki-u.ac.jp.
Kunihiro
K
Ichinose
Tomoki
T
Origuchi
Naoki
N
Tashiro
Shin-Ya
SY
Kawashiri
Naoki
N
Iwamoto
Keita
K
Fujikawa
Toshiyuki
T
Aramaki
Kazuhiko
K
Arima
Mami
M
Tamai
Satoshi
S
Yamasaki
Hideki
H
Nakamura
Hiroyuki
H
Moriuchi
Atsushi
A
Kawakami
D000368:Aged; D003449:Cryoglobulinemia / Q000150:complications* / Q000175:diagnosis / Q000821:virology; D020031:Epstein-Barr Virus Infections / Q000150:complications* / Q000175:diagnosis / Q000821:virology; D017809:Fatal Outcome; D005260:Female; D006801:Humans