Hepatoprotective and antioxidant effect of tender coconut water on carbon tetrachloride induced liver injury in rats.
Hepatoprotective and antioxidant effects of tender coconut water (TCW) were investigated in carbon tetrachloride (CCl4)-intoxicated female rats. Liver damage was evidenced by the increased levels of serum glutamate oxaloacetate transaminase (SGOT), serum glutamate pyruvate transaminase (SGPT) and decreased levels of serum proteins and by histopathological studies in CCl4-intoxicated rats. Increased lipid peroxidation was evidenced by elevated levels of thiobarbituric acid reactive substance (TBARS) viz, malondialdehyde (MDA), hydroperoxides (HP) and conjugated dienes (CD), and also by significant decrease in antioxidant enzymes activities, such as superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (Gpx) and glutathione reductase (GR) and also reduced glutathione (GSH) content in liver. On the other hand, CCl4-intoxicated rats treated with TCW retained almost normal levels of these constituents. Decreased activities of antioxidant enzymes in CCl4-intoxicated rats and their reversal of antioxidant enzyme activities in TCW treated rats, shows the effectiveness of TCW in combating CCl4-induced oxidative stress. Hepatoprotective effect of TCW is also evidenced from the histopathological studies of liver, which did not show any fatty infiltration or necrosis, as observed in CCl4-intoxicated rats.
Department of Biochemistry University of Kerala, Kariavattom, Thiruvananthapuram 695 581, India.
Anthony Loperito
AL
Loki
T
T
Rajamohan
D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D001628:Beverages; D002251:Carbon Tetrachloride / Q000633:toxicity*; D056486:Chemical and Drug Induced Liver Injury / Q000201:enzymology / Q000378:metabolism* / Q000473:pathology / Q000517:prevention & control; D003059:Cocos / Q000737:chemistry*; D019610:Cytoprotection / Q000187:drug effects*; D005260:Female; D008099:Liver / Q000187:drug effects* / Q000201:enzymology / Q000293:injuries / Q000378:metabolism; D051381:Rats
D000975:Antioxidants; D002251:Carbon Tetrachloride