Concomitant use of pazopanib and simvastatin increases the risk of transaminase elevations in patients with cancer.
Department of Genetics, GlaxoSmithKline Research and Development, Stevenage, UK.
C F
CF
Xu
Department of Genetics, GlaxoSmithKline Research and Development, Research Triangle Park, Philadelphia.
Z
Z
Xue
Department of Genetics, GlaxoSmithKline Research and Development, Research Triangle Park, Philadelphia.
N
N
Bing
Department of Genetics, GlaxoSmithKline Research and Development, Research Triangle Park, Philadelphia.
K S
KS
King
Department of Clinical Statistics, GlaxoSmithKline Research and Development, Philadelphia, USA.
L A
LA
McCann
Department of Medical Oncology, University of Western Sydney School of Medicine, Sydney, Australia.
P L
PL
de Souza
Department of Oncology, GlaxoSmithKline Research and Development, Research Triangle Park, Philadelphia, United States.
V L
VL
Goodman
Department of Genetics, GlaxoSmithKline Research and Development, Stevenage, UK.
C F
CF
Spraggs
Department of Genetics, GlaxoSmithKline Research and Development, Research Triangle Park, Philadelphia.
V E
VE
Mooser
Department of Oncology, GlaxoSmithKline Research and Development, Research Triangle Park, Philadelphia, United States.
L N
LN
Pandite
D000070997:ATP Binding Cassette Transporter, Subfamily G, Member 2; D018528:ATP-Binding Cassette Transporters / Q000235:genetics; D000410:Alanine Transaminase / Q000097:blood*; D000924:Anticholesteremic Agents / Q000009:adverse effects / Q000494:pharmacology* / Q000627:therapeutic use; D000970:Antineoplastic Agents / Q000009:adverse effects / Q000494:pharmacology* / Q000627:therapeutic use; D056486:Chemical and Drug Induced Liver Injury / Q000453:epidemiology / Q000235:genetics; D002986:Clinical Trials as Topic; D004347:Drug Interactions; D006801:Humans; D006937:Hypercholesterolemia / Q000097:blood / Q000188:drug therapy; D015994:Incidence; D007191:Indazoles; D009363:Neoplasm Proteins / Q000235:genetics; D009369:Neoplasms / Q000097:blood* / Q000188:drug therapy; D020641:Polymorphism, Single Nucleotide; D011743:Pyrimidines / Q000009:adverse effects / Q000494:pharmacology* / Q000627:therapeutic use; D012016:Reference Values; D019821:Simvastatin / Q000009:adverse effects / Q000494:pharmacology* / Q000627:therapeutic use; D013449:Sulfonamides / Q000009:adverse effects / Q000494:pharmacology* / Q000627:therapeutic use
C116614:ABCG2 protein, human; D000070997:ATP Binding Cassette Transporter, Subfamily G, Member 2; D018528:ATP-Binding Cassette Transporters; D000924:Anticholesteremic Agents; D000970:Antineoplastic Agents; D007191:Indazoles; D009363:Neoplasm Proteins; D011743:Pyrimidines; D013449:Sulfonamides; C516667:pazopanib; D019821:Simvastatin; D000410:Alanine Transaminase