Blood transfusion in sickle cell disease leading to posterior reversible encephalopathy syndrome (PRES).
Children with sickle cell disease have a very high risk of lifelong neurologic morbidity and mortality. Cerebrovascular accidents are a known complication in children with sickle cell disease. Posterior reversible encephalopathy syndrome is a constellation of acute neurologic findings increasingly recognized in pediatric critical care population with evidence of vasogenic edema on brain imaging possibly due to cerebral vascular endothelial cell dysfunction. This report, for the first time, describes a young adult with sickle cell disease who developed posterior reversible encephalopathy syndrome following blood transfusion.
1Department of Pediatrics, Division of Pediatric Critical Care Medicine, Albert Einstein College of Medicine of Yeshiva University, Children's Hospital at Montefiore, Bronx, NY, USA.
Shashi
S
Raj
James
J
Killinger
Philip
P
Overby
D000755:Anemia, Sickle Cell / Q000473:pathology / Q000628:therapy*; D001921:Brain / Q000473:pathology; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D054038:Posterior Leukoencephalopathy Syndrome / Q000209:etiology* / Q000473:pathology; D065227:Transfusion Reaction; D055815:Young Adult