An investigation of the relationship between hemodynamics and thrombus deposition within patient-specific models of abdominal aortic aneurysm.
The relationship between hemodynamics and thrombus deposition in abdominal aortic aneurysm is investigated for three patients (A, B and C), each with mature fusiform aneurysms. Our methodology utilises initial and follow-up computerised tomography scans for each patient to identify regions of mural thrombus growth and to provide patient-specific models for hemodynamic analysis using computational fluid dynamics. The intervals between scans for patients A, B and C were 17, 15 and 3 months, respectively. The simulations were performed using physiologically realistic boundary conditions. The hemodynamic features of the flow considered include the velocity field, the shear strain rate field, the time averaged wall shear stress and the oscillatory shear index. The parameter that showed best correlation with the location of thrombus growth was the oscillatory shear index. In particular, in the case of patient C where the interval between scans was the shortest, thrombus growth was observed at regions of low oscillatory shear index (OSI < 0.1).
School of Mechanical and Materials Engineering, University College Dublin Engineering and Materials Science Centre, Dublin, Ireland. malachy.orourke@ucd.ie
Malachy J
MJ
O'Rourke
James P
JP
McCullough
Sinead
S
Kelly
D000368:Aged; D001012:Aorta, Abdominal / Q000473:pathology / Q000503:physiopathology*; D017544:Aortic Aneurysm, Abdominal / Q000150:complications / Q000473:pathology / Q000503:physiopathology*; D001783:Blood Flow Velocity; D001794:Blood Pressure; D003198:Computer Simulation; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D008955:Models, Cardiovascular; D033081:Shear Strength; D013927:Thrombosis / Q000150:complications / Q000473:pathology / Q000503:physiopathology*