MRIgHIFU: a tool for image-guided therapeutics.
High-intensity focused ultrasound (HIFU) provides focal delivery of mechanical energy deep into the body. This energy can be used to elevate the tissue temperature to such a degree that ablation is achieved. The elevated temperature can also be used to release drugs from temperature-sensitive carriers or activate therapeutic molecules using mechanical or thermal energy. Lower dose exposures modify the vasculature to allow large molecules to diffuse from blood in the surrounding tissue for local drug delivery. The energy delivery can be targeted and monitored using magnetic resonance imaging (MRI). The online image guidance and monitoring provides treatment delivery that is customized to each patient such that optimal, effective treatment can be achieved. This ability to localize and customize treatment delivery may further enhance the future potential of targeted drugs that are personalized for each patient. This review examines the rapid development of MRI-guided HIFU (MRIgHIFU) methods over the past few years and discuss their future potential.
Imaging Research, Sunnybrook Health Sciences Centre, and Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada. khynynen@sri.utoronto.ca
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Hynynen
D005544:Forecasting; D057086:High-Intensity Focused Ultrasound Ablation / Q000379:methods* / Q000639:trends*; D006801:Humans; D007089:Image Enhancement / Q000379:methods; D053783:Magnetic Resonance Imaging, Interventional / Q000379:methods* / Q000639:trends*; D025321:Surgery, Computer-Assisted / Q000295:instrumentation* / Q000379:methods / Q000639:trends*