Expression pattern of the transforming growth factor β signaling genes in human peripheral blood mononuclear cells after exercise-inflammatory aspects.
OBJECTIVE
The present study has focused on the identification of differences between the expression pattern of TGF-β signaling pathway genes in athletes after exercise.


METHODS
The study group consisted of three healthy cyclists, which were collected pre-exercise, immediately postexercise, and after 15 min of recovery. The analysis of the expression profile of genes related to the TGF-β signal transduction pathway was performed in peripheral blood mononuclear cells using HG-U133A oligonucleotide microarrays.


RESULTS
A significant differential gene expression was recorded for RUNX3, TGFBR3, MLC1, and GRB2.


CONCLUSIONS
The effect of physical exercise on immune response may be essential for human health. Moreover, alterations of TGF-β signaling can be involved in the process of adaptation of human organism to physical exertion.
Department of Molecular Biology, Medical University of Silesia, Sosnowiec, Poland. magdakimsa@gmail.com
Magdalena
M
Kimsa
Barbara
B
Strzalka-Mrozik
Malgorzata
M
Kimsa
Joanna
J
Gola
Aleksandra
A
Kochanska-Dziurowicz
Aleksandra
A
Zebrowska
Grazyna
G
Janikowska
Urszula
U
Mazurek
Szymon
S
Jonczyk
D000328:Adult; D001642:Bicycling / Q000502:physiology; D015444:Exercise; D020869:Gene Expression Profiling; D006801:Humans; D007963:Leukocytes, Mononuclear / Q000276:immunology / Q000378:metabolism*; D008297:Male; D020411:Oligonucleotide Array Sequence Analysis; D005082:Physical Exertion; D015398:Signal Transduction; D059467:Transcriptome; D016212:Transforming Growth Factor beta / Q000235:genetics* / Q000276:immunology* / Q000378:metabolism; D055815:Young Adult
D016212:Transforming Growth Factor beta