Enhancing engraftment of cord blood cells via insight into the biology of stem/progenitor cell function.
Cord blood (CB) transplantation has been used over the last 24 years to treat patients with malignant and nonmalignant disorders. CB has its advantages and disadvantages compared with other sources of hematopoietic stem cells (HSCs) and hematopoietic progenitor cells (HPCs) for transplantation. More knowledge of the cytokines and intracellular signaling molecules regulating HSCs and HPCs could be used to modulate these regulators for clinical benefit. This review provides information about the general field of CB transplantation and about studies from the author's laboratory that focus on regulation of HSCs and HPCs by CD26/DPPIV, SDF-1/CXCL12, the Rheb2-mTOR pathway, SIRT1, DEK, cyclin-dependent kinase inhibitors, and cytokines/growth factors. Cryopreservation of CB HSCs and HPCs is also briefly discussed.
Department of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, Indiana.
Hal E
HE
Broxmeyer
D000818:Animals; D054377:Chemokine CXCL12 / Q000378:metabolism; D036101:Cord Blood Stem Cell Transplantation / Q000379:methods*; D050756:Cyclin-Dependent Kinase Inhibitor Proteins / Q000378:metabolism; D016207:Cytokines / Q000378:metabolism; D018819:Dipeptidyl Peptidase 4 / Q000378:metabolism; D006082:Graft Enhancement, Immunologic / Q000379:methods*; D006410:Hematopoiesis; D006412:Hematopoietic Stem Cells / Q000378:metabolism; D006801:Humans; D047908:Intracellular Signaling Peptides and Proteins / Q000378:metabolism; D015398:Signal Transduction; D056564:Sirtuin 1 / Q000378:metabolism; D058570:TOR Serine-Threonine Kinases / Q000378:metabolism
D054377:Chemokine CXCL12; D050756:Cyclin-Dependent Kinase Inhibitor Proteins; D016207:Cytokines; D047908:Intracellular Signaling Peptides and Proteins; D058570:TOR Serine-Threonine Kinases; D018819:Dipeptidyl Peptidase 4; D056564:Sirtuin 1