Effects of fibre-enriched diets on tissue lipid profiles of MSG obese rats.
In order to investigate the influence of some fibre-enriched diets on tissue lipids in an animal model of obesity induced by the administration of monosodium glutamate (MSG), obese rats were fed diets containing 30% of Acha, Cassava, Maize and Plantain for five weeks and weight gain, feed intake and lee index were recorded. The lipid profiles of plasma, erythrocytes, kidney, heart and liver as well as hepatic 3-hydroxyl-3-methylglutaryl-CoA (HMG-CoA) reductase activity were measured. The diets significantly (p<0.05) reduced weight gain and lee index in the obese rats. Obesity-induced increase in plasma and erythrocytes lipid levels was significantly (p<0.05) reduced by these diets. MSG-induced obesity also resulted in a significant increase (p<0.05) in hepatic cholesterol level which was reduced by the diets. MSG-obesity was characterised by a significant (p<0.05) increase in cholesterol, triacylglycerol and phospholipids in kidney and this was reversed by the diets except Maize which did not reverse the increased cholesterol level. Only Acha reversed the obesity-induced increase in heart cholesterol and phospholipids. The increased activity of hepatic HMG-CoA reductase associated with obesity was also significantly (p<0.05) reduced by the diets. In conclusion, dyslipidemia associated with MSG-induced obesity could be attenuated by consumption of fibre-enriched diets.
Department of Biochemistry, University of Agriculture, Abeokuta, Ogun State, Nigeria.
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Rotimi
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Olayiwola
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Ademuyiwa
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Balogun
D000818:Animals; D002784:Cholesterol / Q000097:blood; D004043:Dietary Fiber / Q000494:pharmacology*; D004195:Disease Models, Animal; D050171:Dyslipidemias / Q000139:chemically induced; D006903:Hydroxymethylglutaryl CoA Reductases / Q000378:metabolism; D007668:Kidney / Q000187:drug effects / Q000378:metabolism; D050356:Lipid Metabolism / Q000187:drug effects*; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D008297:Male; D009206:Myocardium / Q000378:metabolism; D009765:Obesity / Q000139:chemically induced / Q000178:diet therapy* / Q000378:metabolism*; D009929:Organ Size / Q000187:drug effects; D010743:Phospholipids / Q000378:metabolism; D051381:Rats; D012970:Sodium Glutamate / Q000633:toxicity*; D014280:Triglycerides / Q000097:blood; D015430:Weight Gain
D004043:Dietary Fiber; D010743:Phospholipids; D014280:Triglycerides; D002784:Cholesterol; D006903:Hydroxymethylglutaryl CoA Reductases; D012970:Sodium Glutamate