Inhibition of breast cancer metastasis via PITPNM3 by pachymic acid.
Breast cancer metastasis is the most common cause of cancer-related death in women. Thus, seeking targets of breast tumor cells is an attractive goal towards improving clinical treatment. The present study showed that CCL18 from tumor-associated macrophages could promote breast cancer metastasis via PITPNM3. In addition, we found that pachymic acid (PA) could dose-dependently inhibit migration and invasion of MDA-MB-231 cells, with or without rCCL18 stimulation. Furthermore, evidence was obtained that PA could suppress the phosphorylation of PITPNM3 and the combination of CCL18 and PITPNM3. Therefore, we speculate that PA could inhibit breast cancer metastasis via PITPNM3.
Department of Breast, the First School of Clinical Medicine, Zhejiang Chinese Medical University, Hangzhou, China. hongri20120405@hotmail.com
Ri
R
Hong
Min-He
MH
Shen
Xiao-Hong
XH
Xie
Shan-Ming
SM
Ruan
D015153:Blotting, Western; D001943:Breast Neoplasms / Q000378:metabolism / Q000517:prevention & control* / Q000556:secondary; D002135:Calcium-Binding Proteins / Q000378:metabolism*; D002465:Cell Movement / Q000187:drug effects*; D019742:Chemokines, CC / Q000378:metabolism*; D005260:Female; D005434:Flow Cytometry; D006801:Humans; D008565:Membrane Proteins / Q000378:metabolism*; D010741:Phospholipases A / Q000037:antagonists & inhibitors; D010766:Phosphorylation / Q000187:drug effects; D014315:Triterpenes / Q000494:pharmacology*; D014407:Tumor Cells, Cultured; D014945:Wound Healing / Q000187:drug effects*
C111792:CCL18 protein, human; D002135:Calcium-Binding Proteins; D019742:Chemokines, CC; D008565:Membrane Proteins; C117885:PITPNM3 protein, human; D014315:Triterpenes; D010741:Phospholipases A; C102487:pachymic acid