Is etravirine and two nucleosides an option for HIV with an isolated K103N mutation?
We report long-term virologic response to etravirine and tenofovir/emtricitabine in four HIV-1-infected patients who had prior standard genotypic resistance testing showing an isolated K103N mutation (three acquired, one transmitted). In three patients tested, the K103N mutation was detected in cellular HIV-1 DNA whereas remaining suppressed on etravirine plus tenofovir/emtricitabine.
HIV Unit, Internal Medicine Service bMicrobiology Service. Hospital Universitario La Paz, IdiPAZ, Madrid, Spain.
Miriam
M
Estebanez
Natalia
N
Stella-Ascariz
Guillermo
G
Ruiz-Carrascoso
Francisco Xavier
FX
Zamora
Silvia
S
García-Bujalance
Jose I
JI
Bernardino
Ignacio
I
Pérez-Valero
Alejandro
A
Martin-Quirós
Jesús
J
Mingorance
Jose R
JR
Arribas
D000225:Adenine / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000627:therapeutic use; D000328:Adult; D019380:Anti-HIV Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D001216:Asparagine; D003841:Deoxycytidine / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000627:therapeutic use; D024921:Drug Resistance, Multiple, Viral / Q000187:drug effects / Q000235:genetics; D004359:Drug Therapy, Combination; D000068679:Emtricitabine; D005260:Female; D005838:Genotype; D006679:HIV Seropositivity / Q000188:drug therapy* / Q000235:genetics; D015497:HIV-1 / Q000187:drug effects / Q000235:genetics*; D006801:Humans; D008239:Lysine; D008297:Male; D009154:Mutation; D009570:Nitriles; D063065:Organophosphonates / Q000008:administration & dosage / Q000627:therapeutic use*; D011724:Pyridazines / Q000008:administration & dosage / Q000627:therapeutic use*; D011743:Pyrimidines; D018894:Reverse Transcriptase Inhibitors / Q000008:administration & dosage / Q000627:therapeutic use*; D000068698:Tenofovir
D019380:Anti-HIV Agents; D009570:Nitriles; D063065:Organophosphonates; D011724:Pyridazines; D011743:Pyrimidines; D018894:Reverse Transcriptase Inhibitors; C451734:etravirine; D003841:Deoxycytidine; D001216:Asparagine; D000068698:Tenofovir; D000068679:Emtricitabine; D000225:Adenine; D008239:Lysine