title: [Serum level of IL-17 in patients with multiple myeloma and its clinical significance].
abstract: This study was purposed to detect the serum concentrations of interleukin-17 (IL-17) in patients with multiple myeloma (MM), and to investigate its clinical significance. the serum IL-17 levels in 33 patients with MM and 20 normal control subjects were quantified by using double antibody sandwich ELISA, and serum β2-microglobulin (β2-MG) levels were detected by radioimmunoassay. The results showed that the serum concentrations of IL-17 and β2-MG in patients with MM were significantly higher than those in the control group (P < 0.001), the serum concentrations of IL-17 and β2-MG in active stage were significantly higher than those in stable stage (P < 0.05), the serum concentrations of IL-17 and β2-MG were significantly higher in stage III than that in stage II according to International Staging System (ISS) (P < 0.05), the serum IL-17 and β2-MG levels were significantly correlated (r = 0.690, P < 0.05). It is concluded that the serum IL-17 level correlates with active/stable stages of MM and staging of MM, IL-17 may play an important role in development stage and prognosis of this disease.
authors.affiliation: Department of Hematology, First Hospital of Shanxi Medical University, Taiyuan, China. zxlsj@126.com
authors.forename: Xiu-Lian
authors.initials: XL
authors.lastname: Zhang
authors.forename: Wei-Hua
authors.initials: WH
authors.lastname: Zhang
authors.forename: Xing-Huo
authors.initials: XH
authors.lastname: Fan
authors.forename: Fang
authors.initials: F
authors.lastname: Wei
authors.forename: Miao
authors.initials: M
authors.lastname: Zhang
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D020381:Interleukin-17 / Q000097:blood*; D008297:Male; D008875:Middle Aged; D009101:Multiple Myeloma / Q000097:blood* / Q000473:pathology; D009367:Neoplasm Staging; D011379:Prognosis
chemical_list: D020381:Interleukin-17