title: A proline-based phosphine template for Staudinger ligation.
abstract: A proline-based phosphine template enabling a rapid Staudinger ligation of azide-containing substrates under mild conditions is reported. This reaction has a second-order rate constant of 1.12 M(-1) s(-1). It is expected that the proline-based Staudinger ligation strategy will be a useful method for bioconjugation and proline based peptide coupling.
authors.affiliation: Department of Chemistry, Washington State University, Pullman, Washington 99164, USA.
authors.forename: Chung-Min
authors.initials: CM
authors.lastname: Park
authors.forename: Wei
authors.initials: W
authors.lastname: Niu
authors.forename: Chunrong
authors.initials: C
authors.lastname: Liu
authors.forename: Tyler D
authors.initials: TD
authors.lastname: Biggs
authors.forename: Jiantao
authors.initials: J
authors.lastname: Guo
authors.forename: Ming
authors.initials: M
authors.lastname: Xian
mesh_terms: D001386:Azides / Q000737:chemistry; D002625:Chemistry, Organic / Q000379:methods*; D020650:Combinatorial Chemistry Techniques; D015394:Molecular Structure; D010455:Peptides / Q000737:chemistry; D011392:Proline / Q000031:analogs & derivatives* / Q000737:chemistry*
chemical_list: D001386:Azides; D010455:Peptides; D011392:Proline