title: Tissue engineering as a potential alternative or adjunct to surgical reconstruction in treating pelvic organ prolapse.
abstract: OBJECTIVE
  Cell-based tissue engineering strategies could potentially provide attractive alternatives to surgical reconstruction of native tissue or the use of surgical implants in treating pelvic organ prolapse (POP).
  
  
  METHODS
  Based on a search in PubMed, this review focuses on candidate cell types, scaffolds, and trophic factors used in studies examining cell-based tissue engineering strategies to treat POP, stress urinary incontinence (SUI), and the closely related field of hernias.
  
  
  RESULTS
  In contrast to the field of SUI, the use of cell-based tissue engineering strategies to treat POP are very sparsely explored, and only preclinical studies exist.
  
  
  CONCLUSIONS
  The available evidence suggests that the use of autologous muscle-derived cells, fibroblasts, or mesenchymal stem cells seeded on biocompatible, degradable, and potentially growth-promoting scaffolds could be an alternative to surgical reconstruction of native tissue or the use of conventional implants in treating POP. However, the vagina is a complex organ with great demands of functionality, and the perfect match of scaffold, cell, and trophic factor has yet to be found and tested in preclinical studies. Important issues such as safety and economy must also be addressed before this approach is ready for clinical studies.
authors.affiliation: Department of Obstetrics and Gynecology, Copenhagen University Hospital, Herlev, Denmark.
authors.forename: M
authors.initials: M
authors.lastname: Boennelycke
authors.forename: S
authors.initials: S
authors.lastname: Gras
authors.forename: G
authors.initials: G
authors.lastname: Lose
mesh_terms: D000818:Animals; D064987:Cell- and Tissue-Based Therapy; D005260:Female; D006801:Humans; D056887:Pelvic Organ Prolapse / Q000628:therapy*; D044968:Regenerative Medicine; D023822:Tissue Engineering; D054457:Tissue Scaffolds