title: Malignant transformation of Madelung's disease in a patient with a coincidental diagnosis of breast cancer: a case report.
abstract: Madelung's disease or multiple symmetric lipomatosis (MSL) is a rare disorder of unknown etiology which typically presents symmetrically subcutaneous accumulation of non-encapsulated adipose tissue which slowly grows around the neck, upper part of the arms, pelvis, back and thigh. This disease is also frequently associated with hepatopathy, glucose intolerance, hyperuricemia, and malignant tumors of the upper airways. Nevertheless, only one description of malignant transformation of Madelung's disease has been presented in literature. Here, we report a case of liposarcomatous transformation of Madelung's disease in a 59-year-old Italian woman with a coincidental diagnosis of breast cancer.
  The virtual slide for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/3480884087499351.
authors.affiliation: Department of Oncology, Gynecologic Oncology Unit, Catholic University, Campobasso, Italy.
authors.forename: Maddalena
authors.initials: M
authors.lastname: Borriello
authors.forename: Alessandro
authors.initials: A
authors.lastname: Lucidi
authors.forename: Arnaldo
authors.initials: A
authors.lastname: Carbone
authors.forename: Vito
authors.initials: V
authors.lastname: Iannone
authors.forename: Gabriella
authors.initials: G
authors.lastname: Ferrandina
mesh_terms: D001943:Breast Neoplasms / Q000473:pathology*; D018270:Carcinoma, Ductal, Breast / Q000473:pathology*; D002471:Cell Transformation, Neoplastic / Q000473:pathology; D005260:Female; D006801:Humans; D008069:Lipomatosis, Multiple Symmetrical / Q000473:pathology*; D008080:Liposarcoma / Q000473:pathology*; D008875:Middle Aged; D009378:Neoplasms, Multiple Primary / Q000473:pathology*