title: Fine-mapping of IL16 gene and prostate cancer risk in African Americans.
abstract: BACKGROUND
  Prostate cancer is the most common type of cancer among men in the United States, and its incidence and mortality rates are disproportionate among ethnic groups. Although genome-wide association studies of European descents have identified candidate loci associated with prostate cancer risk, including a variant in IL16, replication studies in African Americans (AA) have been inconsistent. Here we explore single-nucleotide polymorphism (SNP) variation in IL16 in AAs and test for association with prostate cancer.
  
  
  METHODS
  Association tests were conducted for 2,257 genotyped and imputed SNPs spanning IL16 in 605 AA prostate cancer cases and controls from Washington, D.C. Eleven of them were also genotyped in a replication population of 1,093 AAs from Chicago. We tested for allelic association adjusting for age, global and local West African ancestry.
  
  
  RESULTS
  Analyses of genotyped and imputed SNPs revealed that a cluster of IL16 SNPs were significantly associated with prostate cancer risk. The strongest association was found at rs7175701 (P = 9.8 × 10(-8)). In the Chicago population, another SNP (rs11556218) was associated with prostate cancer risk (P = 0.01). In the pooled analysis, we identified three independent loci within IL16 that were associated with prostate cancer risk. SNP expression quantitative trait loci analyses revealed that rs7175701 is predicted to influence the expression of IL16 and other cancer-related genes.
  
  
  CONCLUSIONS
  Our study provides evidence that IL16 polymorphisms play a role in prostate cancer susceptibility among AAs.
  
  
  CONCLUSIONS
  Our findings are significant given that there has been limited focus on the role of IL16 genetic polymorphisms on prostate cancer risk in AAs.
authors.affiliation: Institute of Human Genetics, College of Medicine, School of Public Health, University of Illinois at Chicago, Chicago, IL 60607-4067, USA.
authors.forename: Ken
authors.initials: K
authors.lastname: Batai
authors.forename: Ebony
authors.initials: E
authors.lastname: Shah
authors.forename: Adam B
authors.initials: AB
authors.lastname: Murphy
authors.forename: Jennifer
authors.initials: J
authors.lastname: Newsome
authors.forename: Maria
authors.initials: M
authors.lastname: Ruden
authors.forename: Chiledum
authors.initials: C
authors.lastname: Ahaghotu
authors.forename: Rick A
authors.initials: RA
authors.lastname: Kittles
mesh_terms: D001741:Black or African American / Q000235:genetics*; D000483:Alleles; D016022:Case-Control Studies; D004219:District of Columbia / Q000453:epidemiology; D020022:Genetic Predisposition to Disease; D055106:Genome-Wide Association Study; D006801:Humans; D019410:Interleukin-16 / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D011471:Prostatic Neoplasms / Q000453:epidemiology / Q000208:ethnology* / Q000235:genetics*; D012307:Risk Factors
chemical_list: D019410:Interleukin-16