title: Non-typhoidal Salmonella encephalopathy involving lipopolysaccharide in cattle.
abstract: This study assessed the involvement of lipopolysaccharide (LPS) in the non-typhoidal Salmonella encephalopathy (NTSE) caused by a unique isolate of Salmonella enterica serovar Saint-paul (SstpNPG). NTSE was prevented by genetic (deletion of murE) or pharmacologic (polymyxin) disruption of LPS on SstpNPG although the disruption of LPS did not deter brain penetration of the strain. This is the first study to demonstrate that LPS is involved in the manifestations of NTSE.
authors.affiliation: Department of Biomedical Sciences, College of Veterinary Medicine, Iowa State University, Ames, IA 50011, USA.
authors.forename: N
authors.initials: N
authors.lastname: Xiong
authors.forename: M T
authors.initials: MT
authors.lastname: Brewer
authors.forename: K L
authors.initials: KL
authors.lastname: Anderson
authors.forename: S A
authors.initials: SA
authors.lastname: Carlson
mesh_terms: D000818:Animals; D001812:Blood-Brain Barrier / Q000382:microbiology; D001927:Brain Diseases / Q000382:microbiology / Q000662:veterinary*; D002417:Cattle; D002418:Cattle Diseases / Q000382:microbiology*; D008070:Lipopolysaccharides / Q000037:antagonists & inhibitors* / Q000378:metabolism*; D011113:Polymyxins / Q000494:pharmacology; D012481:Salmonella Infections, Animal / Q000382:microbiology*; D019779:Salmonella enterica / Q000378:metabolism* / Q000472:pathogenicity
chemical_list: D008070:Lipopolysaccharides; D011113:Polymyxins