title: Synthesis and biological evaluation of a novel series of chalcones incorporated pyrazole moiety as anticancer and antimicrobial agents.
abstract: A newly synthesized series of chalcone derivatives containing pyrazole rings were synthesized and evaluated for their cytotoxic activities in vitro against several human cancer cell lines. Most of the prepared compounds showed potential cytotoxicity against human breast cancer cell lines MCF-7, HEPG-2, and HCT-116. Also the compounds were evaluated as antimicrobial agents. The three compounds 3, 4, and 5 were proved to be better anticancer agents than the positive standard doxorubicin with IC50 values (4.7, 4.4, and 3.9 μg/ml) against the same human cancer cell lines, whereas compounds 5 and 6 showed the most active antimicrobial compounds in comparison to the other chalcones.
authors.affiliation: Department of Chemistry (Biochemistry Branch), Faculty of Science, Cairo University, Giza, Egypt.
authors.forename: Magda F
authors.initials: MF
authors.lastname: Mohamed
authors.forename: Mervat S
authors.initials: MS
authors.lastname: Mohamed
authors.forename: Samia A
authors.initials: SA
authors.lastname: Shouman
authors.forename: Mohamed M
authors.initials: MM
authors.lastname: Fathi
authors.forename: Ismail Abdelshafy
authors.initials: IA
authors.lastname: Abdelhamid
mesh_terms: D000890:Anti-Infective Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology / Q000592:standards; D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology / Q000592:standards; D001419:Bacteria / Q000187:drug effects; D049109:Cell Proliferation / Q000187:drug effects; D047188:Chalcones / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D004317:Doxorubicin / Q000494:pharmacology; D005260:Female; D005658:Fungi / Q000187:drug effects; D045325:HCT116 Cells; D056945:Hep G2 Cells; D006801:Humans; D020128:Inhibitory Concentration 50; D061986:MCF-7 Cells; D011720:Pyrazoles / Q000737:chemistry / Q000494:pharmacology
chemical_list: D000890:Anti-Infective Agents; D000970:Antineoplastic Agents; D047188:Chalcones; D011720:Pyrazoles; C031280:pyrazole; D004317:Doxorubicin