title: Ventricular tachycardia in coronary artery disease.
abstract: Ventricular arrhythmias are important contributors to morbidity and mortality in patients with coronary artery disease. Ventricular fibrillation accounts for the majority of deaths occurring in the acute phase of ischemia, whereas sustained, monomorphic ventricular tachycardia due to reentry generated in the scar tissue develops most often in the setting of healed myocardial infarction, especially in patients with lower left ventricular ejection fraction. Despite determinant advances in population education and myocardial infarction management, the ventricular tachycardia risk in the overall population with coronary artery disease continues to be a major problem in clinical practice. The initial evaluation of a patient presenting with ventricular tachycardia requires a 12-lead electrocardiogram, which can be helpful to confirm the diagnosis, suggest the presence of potential underlying heart disease, and identify the location of the ventricular tachycardia circuit. An invasive electrophysiologic study is usually crucial to determine the mechanism of the arrhythmia once induced and to provide guidance for ablation. The approach for ventricular tachycardia ablation depends on several factors, including inducibility, sustainability, and clinical tolerance of ventricular tachycardia. The paper also reviews other therapeutic options for patients with ventricular tachycardia associated with coronary artery disease, including antiarrhythmic drug therapy, surgical ablation, and current implantable cardioverter-defibrillator indications.
authors.affiliation: Sección de Arritmias, Servicio de Cardiología, Hospital del Mar, Barcelona, España.
authors.forename: Begoña
authors.initials: B
authors.lastname: Benito
authors.forename: Mark E
authors.initials: ME
authors.lastname: Josephson
mesh_terms: D000889:Anti-Arrhythmia Agents / Q000627:therapeutic use; D006348:Cardiac Surgical Procedures; D019090:Case Management; D017115:Catheter Ablation; D003324:Coronary Artery Disease / Q000150:complications* / Q000503:physiopathology / Q000628:therapy; D017147:Defibrillators, Implantable; D004452:Echocardiography / Q000379:methods; D004562:Electrocardiography; D055724:Electrophysiological Phenomena; D006801:Humans; D017180:Tachycardia, Ventricular / Q000175:diagnosis / Q000000981:diagnostic imaging / Q000209:etiology* / Q000503:physiopathology / Q000628:therapy
chemical_list: D000889:Anti-Arrhythmia Agents