title: Clostridium difficile Colitis and Neutropenic Fever Associated with Docetaxel Chemotherapy in a Patient with Advanced Extramammary Paget's Disease.
abstract: Extramammary Paget's disease is a rare cutaneous malignant neoplasm. Previous studies indicated the efficacy of docetaxel in advanced cases. The common side effects of docetaxel are usually tolerable and seldom life-threatening. We experienced a case of severe pseudomembranous colitis and neutropenic fever that developed just after the first cycle of docetaxel chemotherapy. To the best of our knowledge, there are few reports of pseudomembranous colitis associated with docetaxel administration for skin cancers. The patient showed complete resolution of her symptoms within 2 weeks with an oral metronidazole therapy. During the second and third cycles, the patient received docetaxel safely with lower doses. The present case indicated that pseudomembranous colitis should be included in the differential diagnosis when assessing patients who develop severe diarrhea during systemic chemotherapy with docetaxel.
authors.affiliation: Department of Dermatology, Kyoto University Graduate School of Medicine, Kyoto, Japan.
authors.forename: Yumi
authors.initials: Y
authors.lastname: Nonomura
authors.forename: Atsushi
authors.initials: A
authors.lastname: Otsuka
authors.forename: Yuichiro
authors.initials: Y
authors.lastname: Endo
authors.forename: Akihiro
authors.initials: A
authors.lastname: Fujisawa
authors.forename: Miki
authors.initials: M
authors.lastname: Tanioka
authors.forename: Kenji
authors.initials: K
authors.lastname: Kabashima
authors.forename: Yoshiki
authors.initials: Y
authors.lastname: Miyachi