title: Synthesis and study the antimicrobial activity of novel 2-(1H-indol-3-yl)- N-(3, 4-diphenylthiazol-2(3H)-ylidene) ethanamine derivatives.
abstract: A series of novel 2-(1H-indol-3-yl)-N-(3, 4-diphenylthiazol-2(3H)-ylidene) ethanamine derivatives (5a-o) were synthesized by cyclization of corresponding 1-(2-(1H-indol-3-yl) ethyl)-3-phenylthiourea 3 with 2-bromoacetophenone. All synthesized compounds were evaluated for in vitro antibacterial activity using Gram-positive bacteria and Gram-negative bacteria. In vitro antifungal activity also determined against the five fungal species. Structures of the synthesized compounds were established by elemental analysis and spectral data.
authors.affiliation: Division of Fluoroorganic, Indian Institute of Chemical Technology, Hyderabad-500607, India. kumbhare@iict.res.in
authors.forename: Ravindra M
authors.initials: RM
authors.lastname: Kumbhare
authors.forename: K Vijay
authors.initials: KV
authors.lastname: Kumar
authors.forename: Tulshiram L
authors.initials: TL
authors.lastname: Dadmal
authors.forename: Umesh B
authors.initials: UB
authors.lastname: Kosurkar
authors.forename: K
authors.initials: K
authors.lastname: Appalanaidu
mesh_terms: D000890:Anti-Infective Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects; D060326:Chemistry Techniques, Synthetic; D005658:Fungi / Q000187:drug effects; D013844:Thiazoles / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D000890:Anti-Infective Agents; D013844:Thiazoles