title: The classification of degenerative hip disease.
abstract: It is probable that both genetic and environmental   factors play some part in the aetiology of most cases of degenerative   hip disease. Geneticists have identified some single gene disorders   of the hip, but have had difficulty in identifying the genetics   of many of the common causes of degenerative hip disease. The heterogeneity   of the phenotypes studied is part of the problem. A detailed classification   of phenotypes is proposed. This study is based on careful documentation   of 2003 consecutive total hip replacements performed by a single   surgeon between 1972 and 2000. The concept that developmental problems   may initiate degenerative hip disease is supported. The influences   of gender, age and body mass index are outlined. Biomechanical explanations   for some of the radiological appearances encountered are suggested.   The body weight lever, which is larger than the abductor lever, causes   the abductor power to be more important than body weight. The possibility   that a deficiency in joint lubrication is a cause of degenerative   hip disease is discussed. Identifying the phenotypes may help geneticists   to identify genes responsible for degenerative hip disease, and   eventually lead to a definitive classification.
authors.affiliation: Port Arthur Health Centre, 194 North Court Street, Thunder Bay, Ontario P7A 4V7, Canada. henrycanmore@gmail.com
authors.forename: H W
authors.initials: HW
authors.lastname: Hamilton
authors.forename: J
authors.initials: J
authors.lastname: Jamieson
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000437:Alcoholism / Q000453:epidemiology; D002358:Cartilage, Articular / Q000002:abnormalities / Q000000981:diagnostic imaging* / Q000473:pathology*; D015984:Causality; D015897:Comorbidity; D005260:Female; D005500:Follow-Up Studies; D006620:Hip Fractures / Q000453:epidemiology / Q000601:surgery; D006801:Humans; D008297:Male; D008875:Middle Aged; D015207:Osteoarthritis, Hip / Q000145:classification* / Q000000981:diagnostic imaging*; D010020:Osteonecrosis / Q000139:chemically induced / Q000453:epidemiology; D010641:Phenotype; D011859:Radiography; D013256:Steroids / Q000009:adverse effects; D055815:Young Adult
chemical_list: D013256:Steroids