title: Chemerin is present in human cord blood and is positively correlated with birthweight.
abstract: OBJECTIVE
  Chemerin, a novel adipokine, has been implicated in adipogenesis, inflammation, and metabolism. The aims of this study were to determine the presence of chemerin in cord blood and its association with birthweight.
  
  
  METHODS
  This cross-sectional study included the following: (1) twins with (n = 24) or without (n = 28) birthweight discordancy; and (2) singletons subclassified into small-for-gestational-age (SGA; n = 18); appropriate for gestational age (AGA; n = 33); and large-for-gestational-age (LGA; n = 8). Cord blood chemerin was determined. Parametric and nonparametric statistics were used for analysis.
  
  
  RESULTS
  The results of the study included the following: (1) within the discordant twins group, the median chemerin concentration was significantly lower in the SGA group than in their cotwins; (2) within singletons, the median chemerin concentration was significantly higher in the LGA than the AGA newborns; and (3) the regression model revealed that chemerin was independently associated with birthweight.
  
  
  CONCLUSIONS
  Cord blood chemerin is present in cord blood and its concentrations are positively correlated with birthweight. These novel findings support a role of adipokines in fetal growth.
authors.affiliation: Department of Obstetrics and Gynecology, Sheba Medical Center, Tel-Hashomer, Israel.
authors.forename: Shali
authors.initials: S
authors.lastname: Mazaki-Tovi
authors.forename: Michal
authors.initials: M
authors.lastname: Kasher-Meron
authors.forename: Rina
authors.initials: R
authors.lastname: Hemi
authors.forename: Jigal
authors.initials: J
authors.lastname: Haas
authors.forename: Itai
authors.initials: I
authors.lastname: Gat
authors.forename: Daniel
authors.initials: D
authors.lastname: Lantsberg
authors.forename: Israel
authors.initials: I
authors.lastname: Hendler
authors.forename: Hannah
authors.initials: H
authors.lastname: Kanety
mesh_terms: D000328:Adult; D001724:Birth Weight / Q000502:physiology*; D018925:Chemokines / Q000097:blood*; D003430:Cross-Sectional Studies; D005260:Female; D005312:Fetal Blood / Q000737:chemistry*; D005865:Gestational Age; D006801:Humans; D007231:Infant, Newborn; D036341:Intercellular Signaling Peptides and Proteins; D011247:Pregnancy; D059285:Pregnancy, Twin / Q000097:blood / Q000502:physiology
chemical_list: D018925:Chemokines; D036341:Intercellular Signaling Peptides and Proteins; C478630:RARRES2 protein, human