title: Successful response to cidofovir of adenovirus hepatitis during chemotherapy in a child with hepatoblastoma.
abstract: BACKGROUND
  Adenoviral infections are endemic in the pediatric population. Most of these infections are mild and self-limited in immunocompetent individuals. Although in profoundly immunocompromised hosts after solid organ or stem cell transplantation, adenovirus may cause fulminant hepatitis or other life-threatening infections, this is a rare complication in patients receiving standard chemotherapy.
  
  
  METHODS
  We report a case of severe adenovirus hepatitis in a 7-month-old child receiving induction chemotherapy for hepatoblastoma who fully recovered after treatment with cidofovir.
  
  
  CONCLUSIONS
  To our knowledge, this is the first report documenting recovering of severe adenoviral hepatitis in a nontransplanted immunocompromised host.
authors.affiliation: Pediatric Oncology Unit, Department of Pediatrics, University Hospital Reina Sofía, Córdoba, Spain. marielmateos@gmail.com
authors.forename: M Elena
authors.initials: ME
authors.lastname: Mateos
authors.forename: Eduardo
authors.initials: E
authors.lastname: López-Laso
authors.forename: Juan L
authors.initials: JL
authors.lastname: Pérez-Navero
authors.forename: M José
authors.initials: MJ
authors.lastname: Peña
authors.forename: M José
authors.initials: MJ
authors.lastname: Velasco
mesh_terms: D000258:Adenovirus Infections, Human / Q000188:drug therapy*; D000998:Antiviral Agents / Q000627:therapeutic use*; D000077404:Cidofovir; D003596:Cytosine / Q000031:analogs & derivatives* / Q000627:therapeutic use; D005260:Female; D006525:Hepatitis, Viral, Human / Q000188:drug therapy*; D018197:Hepatoblastoma / Q000150:complications / Q000188:drug therapy*; D006801:Humans; D007223:Infant; D008113:Liver Neoplasms / Q000150:complications / Q000188:drug therapy*; D063065:Organophosphonates / Q000627:therapeutic use*
chemical_list: D000998:Antiviral Agents; D063065:Organophosphonates; D003596:Cytosine; D000077404:Cidofovir