title: Effect of intratympanic dexamethasone, memantine and piracetam on cellular apoptosis due to cisplatin ototoxicity.
abstract: OBJECTIVE
  This study aimed to contribute to the literature on the prevention and treatment of ototoxicity due to various drugs and chemicals.
  
  
  METHODS
  This study compared the histological effects of intratympanic dexamethasone, memantine and piracetam on cellular apoptosis due to cisplatin ototoxicity, in 36 rats.
  
  
  RESULTS
  Dexamethasone and memantine had significant effects on the stria vascularis, organ of Corti and spiral ganglion (p < 0.05). Although piracetam decreased the apoptosis rate, this effect was not statistically significant (p > 0.05).
  
  
  CONCLUSIONS
  Dexamethasone and memantine were found superior to piracetam in reducing apoptosis due to cisplatin ototoxicity. Further studies of this subject are needed, incorporating electron microscopy and auditory brainstem response testing.
authors.affiliation: Department of Otolaryngology, Kocaeli University, Turkey. drmurattopdag@yahoo.com
authors.forename: M
authors.initials: M
authors.lastname: Topdag
authors.forename: M
authors.initials: M
authors.lastname: Iseri
authors.forename: E
authors.initials: E
authors.lastname: Gelenli
authors.forename: M
authors.initials: M
authors.lastname: Yardimoglu
authors.forename: Y
authors.initials: Y
authors.lastname: Yazir
authors.forename: S A
authors.initials: SA
authors.lastname: Ulubil
authors.forename: D O
authors.initials: DO
authors.lastname: Topdag
authors.forename: E
authors.initials: E
authors.lastname: Ustundag
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000009:adverse effects*; D017209:Apoptosis / Q000187:drug effects; D002945:Cisplatin / Q000009:adverse effects*; D003907:Dexamethasone / Q000008:administration & dosage*; D005260:Female; D007759:Labyrinth Diseases / Q000139:chemically induced* / Q000188:drug therapy*; D008559:Memantine / Q000008:administration & dosage*; D010889:Piracetam / Q000008:administration & dosage*; D051381:Rats; D017208:Rats, Wistar; D014432:Tympanic Membrane / Q000187:drug effects*
chemical_list: D000970:Antineoplastic Agents; D003907:Dexamethasone; D002945:Cisplatin; D008559:Memantine; D010889:Piracetam