title: Altered hemispheric symmetry found in left-sided mesial temporal lobe epilepsy with hippocampal sclerosis (MTLE/HS) but not found in right-sided MTLE/HS.
abstract: OBJECTIVE
  The purpose was to investigate the altered hemispheric asymmetry in patients with mesial temporal lobe epilepsy with unilateral hippocampus sclerosis (MTLE/HS).
  
  
  METHODS
  This study examined the hemispheric asymmetry of regional gray matter (GM) and white matter (WM) volume among a group of 13 patients with left-sided MTLE/HS, a group of 10 patients with right-sided MTLE/HS and a group of 21 age- and gender- matched healthy controls by optimized voxel-based morphometry (VBM) based on magnetic resonance imaging.
  
  
  RESULTS
  Compared to healthy controls, abnormal asymmetries were detected in the left-sided MTLE/HS patients. The left-sided MTLE/HS patients had more GM asymmetries (L<R) in the temporal lobes, including the inferior temporal gyrus, middle temporal gyrus and parahippocampal gyrus. There was significant asymmetry (L<R) in subcortical WM of the mesial temporal lobe in left-sided MTLE/HS patients. However, no significant difference was detected in terms of GM and WM asymmetry between the group with right-sided MTLE/HS and normal controls.
  
  
  CONCLUSIONS
  We should approach hemispheric asymmetry in left- and right-sided MTLE/HS patients differently. The study also demonstrates potential future use of VBM in detecting hemispheric asymmetries and lateralization of brain functions.
authors.affiliation: Department of Radiology, Peking Union Medical College Hospital, No. 1 Shuai Fu Yuan, Wang Fu Jing Avenue, Dong Cheng District, Beijing 100730, China. cjr.lujingjing@vip.163.com
authors.forename: Jingjing
authors.initials: J
authors.lastname: Lu
authors.forename: Wenjing
authors.initials: W
authors.lastname: Li
authors.forename: Huiguang
authors.initials: H
authors.lastname: He
authors.forename: Feng
authors.initials: F
authors.lastname: Feng
authors.forename: Zhengyu
authors.initials: Z
authors.lastname: Jin
authors.forename: Liwen
authors.initials: L
authors.lastname: Wu
mesh_terms: D000328:Adult; D004833:Epilepsy, Temporal Lobe / Q000209:etiology* / Q000473:pathology*; D005260:Female; D006624:Hippocampus / Q000473:pathology*; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D009413:Nerve Fibers, Myelinated / Q000473:pathology*; D009474:Neurons / Q000473:pathology*; D015203:Reproducibility of Results; D012598:Sclerosis / Q000150:complications / Q000473:pathology; D012680:Sensitivity and Specificity; D055815:Young Adult