title: New strategies for melanoma immunotherapy: How to overcome immunosuppression in the tumor microenvironment.
abstract: Using ret transgenic mouse model of spontaneous melanoma, we showed an accumulation of melanoma antigen-specific memory T cells. However, their antitumor effects could be blocked by myeloid-derived suppressor cells, tolerogenic dendritic cells and regulatory T cells. We suggest that effective melanoma immunotherapy should include the neutralization of immunosuppressive tumor microenvironment.
authors.affiliation: Skin Cancer Unit; German Cancer Research Center; and, University Hospital Mannheim; Heidelberg, Germany.
authors.forename: Viktor
authors.initials: V
authors.lastname: Umansky