title: Detection of RUNX1-MECOM fusion gene and t(3;21) in a very elderly patient having acute myeloid leukemia with myelodysplasia-related changes.
abstract: An 87-yr-old woman was diagnosed with AML with myelodysplasia-related changes (AML-MRC). The initial complete blood count showed Hb level of 5.9 g/dL, platelet counts of 27 × 10(9)/L, and white blood cell counts of 85.33 × 10(9)/L with 55% blasts. Peripheral blood samples were used in all the tests, as bone marrow examination could not be performed because of the patient's extremely advanced age and poor general health condition. Flow cytometric analysis, chromosome analysis, FISH, and reverse transcriptase-PCR (RT-PCR) results indicated AML-MRC resulting from t(3;21) with the RUNX1-MECOM fusion gene. To our knowledge, this is the second most elderly de novo AML patient associated with t(3;21) to be reported.
authors.affiliation: Department of Medicine, Graduate School, Kyung Hee University, Seoul, Korea.
authors.forename: John Jeongseok
authors.initials: JJ
authors.lastname: Yang
authors.forename: Sun Young
authors.initials: SY
authors.lastname: Cho
authors.forename: Jin-Tae
authors.initials: JT
authors.lastname: Suh
authors.forename: Hee Joo
authors.initials: HJ
authors.lastname: Lee
authors.forename: Woo-In
authors.initials: WI
authors.lastname: Lee
authors.forename: Hwi-Joong
authors.initials: HJ
authors.lastname: Yoon
authors.forename: Sun Kyung
authors.initials: SK
authors.lastname: Baek
authors.forename: Tae Sung
authors.initials: TS
authors.lastname: Park
mesh_terms: D000369:Aged, 80 and over; D001773:Blood Cells / Q000473:pathology; D002891:Chromosomes, Human, Pair 21; D002893:Chromosomes, Human, Pair 3; D005260:Female; D006801:Humans; D007621:Karyotyping; D015470:Leukemia, Myeloid, Acute / Q000150:complications / Q000175:diagnosis* / Q000235:genetics; D060885:Multiplex Polymerase Chain Reaction; D009190:Myelodysplastic Syndromes / Q000150:complications / Q000175:diagnosis* / Q000235:genetics; D015514:Oncogene Proteins, Fusion / Q000235:genetics*; D017422:Sequence Analysis, DNA; D014178:Translocation, Genetic
chemical_list: D015514:Oncogene Proteins, Fusion; C533413:RUNX1-PRDM16 fusion protein, human