title: Soluble CD163 is associated with body mass index and blood pressure in hypertensive obese Saudi patients.
abstract: BACKGROUND
  The hallmark of vascular inflammation is the recruitment of circulating leucocytes, primarily monocytes, macrophages and T lymphocytes, into the vascular wall; however, the link between monocyte/macrophage activation and hypertension has not been established as yet. In this study, we determined how sCD163, a monocyte/macrophage soluble scavenger receptor and immunomodulator, relates to arterial blood pressure (BP) in hypertensive Saudi individuals.
  
  
  METHODS
  A total of 90 (30 non-hypertensive obese, 30 hypertensive obese and 30 lean normotensive controls) adult Saudi subjects, aged 40-60 years, participated in this cross-sectional study. Serum fasting blood glucose, triglycerides, total cholesterol, HDL-cholesterol (HDL-C), LDL-cholesterol (LDL-C), leptin, adiponectin, resistin, insulin, tumour necrosis factor-alpha (TNF-α), PAI-1, angiotensin II, high-sensitivity C-reactive protein (hsCRP) and sCD163 were measured in all subjects studied.
  
  
  RESULTS
  sCD163 concentrations were significantly increased in obese hypertensive patients compared to controls (P=0.016). Positive correlations between sCD163 and body mass index (BMI) (r=0.27, P=0.01), systolic BP (r=0.25, P=0.01), diastolic BP (r=0.33, P=0.001), LDL-C (r=0.21, P=0.04), TNF-α (r=0.23, P=0.02) and hsCRP (r=0.33, P=0.008) were observed. Positive correlations between sCD163 and diastolic BP (r=0.23, P=0.04) and LDL-C (r=0.22, P=0.03) remained significant after controlling for BMI.
  
  
  CONCLUSIONS
  Taken together, these data demonstrate that the monocyte/macrophage activation-related sCD163 is positively associated with BMI and increased arterial BP with the elevation in diastolic BP being independent of the BMI.
authors.affiliation: Biomarkers Research Program, Department of Biochemistry, College of Science, King Saud University, Riyadh, Saudi Arabia. aldaghri2011@gmail.com
authors.forename: Nasser M
authors.initials: NM
authors.lastname: Al-Daghri
authors.forename: Omar S
authors.initials: OS
authors.lastname: Al-Attas
authors.forename: Lotfi S
authors.initials: LS
authors.lastname: Bindahman
authors.forename: Majed S
authors.initials: MS
authors.lastname: Alokail
authors.forename: Khalid M
authors.initials: KM
authors.lastname: Alkharfy
authors.forename: Hossam M
authors.initials: HM
authors.lastname: Draz
authors.forename: Sobhy
authors.initials: S
authors.lastname: Yakout
authors.forename: Philip G
authors.initials: PG
authors.lastname: McTernan
authors.forename: Shaun
authors.initials: S
authors.lastname: Sabico
authors.forename: George P
authors.initials: GP
authors.lastname: Chrousos
mesh_terms: D000328:Adult; D000704:Analysis of Variance; D015703:Antigens, CD / Q000097:blood*; D015214:Antigens, Differentiation, Myelomonocytic / Q000097:blood*; D001794:Blood Pressure / Q000502:physiology*; D015992:Body Mass Index; D016022:Case-Control Studies; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D006973:Hypertension / Q000097:blood*; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000097:blood* / Q000503:physiopathology; D011956:Receptors, Cell Surface / Q000097:blood*; D012529:Saudi Arabia; D000098902:CD163 Antigen
chemical_list: D015703:Antigens, CD; D015214:Antigens, Differentiation, Myelomonocytic; D000098902:CD163 Antigen; D011956:Receptors, Cell Surface