title: Total synthesis of (-)-sessilifoliamide J.
abstract: An efficient synthesis of the Stemona alkaloid (-)-sessilifoliamide J (1) in 12 steps and 7.7% overall yield from the known building block 8 is presented. The synthesis features the Corey lactonization reaction and a highly diastereoselective α-methylation reaction to build the spiro-lactone moiety.
authors.affiliation: Department of Chemistry, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen, Fujian 361005, P. R. China.
authors.forename: Xue-Kui
authors.initials: XK
authors.lastname: Liu
authors.forename: Jian-Liang
authors.initials: JL
authors.lastname: Ye
authors.forename: Yuan-Ping
authors.initials: YP
authors.lastname: Ruan
authors.forename: Yu-Xiu
authors.initials: YX
authors.lastname: Li
authors.forename: Pei-Qiang
authors.initials: PQ
authors.lastname: Huang
mesh_terms: D000470:Alkaloids / Q000138:chemical synthesis* / Q000737:chemistry; D007783:Lactones / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D013141:Spiro Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D041901:Stemonaceae / Q000737:chemistry; D013237:Stereoisomerism
chemical_list: D000470:Alkaloids; D007783:Lactones; D013141:Spiro Compounds; C581436:sessilifoliamide J