title: Application of nanofluids to microsphere generation using MEMS technology.
abstract: This paper provides a literature and patent review on the research and development work contributing to the current status of microsphere generation as an application of nanofluids for drug delivery. The polymer-based microsphere plays an important role to protect protein-based drugs and to deliver the drug to the desired sites. This review covers four microfluidic systems for microsphere generation: membrane emulsification with cross flow, T-junction, hydrodynamic flow focusing and chopper. A discussion on the current state of the arts of the microfluidic systems is addressed, and opportunities for future research are acknowledged.
authors.affiliation: Division of Biomedical Engineering, University of Saskatchewan, Saskatoon, SK, Canada, S7N5A9.
authors.forename: Ki-Young
authors.initials: KY
authors.lastname: Song
authors.forename: Wen-Jun
authors.initials: WJ
authors.lastname: Zhang
mesh_terms: D004337:Drug Carriers / Q000737:chemistry; D057446:Hydrodynamics; D055617:Micro-Electrical-Mechanical Systems; D046210:Microfluidic Analytical Techniques; D008863:Microspheres; D049329:Nanostructures / Q000737:chemistry*; D010330:Patents as Topic; D004364:Pharmaceutical Preparations / Q000737:chemistry
chemical_list: D004337:Drug Carriers; D004364:Pharmaceutical Preparations