title: Comparison of the in vitro hemodynamic performance of new flow diverters for bypass of brain aneurysms.
abstract: One possible treatment for cerebral aneurysms is a porous tubular structure, similar to a stent, called a flow diverter. A flow diverter can be placed across the neck of a cerebral aneurysm to induce the cessation of flow and initiate the formation of an intra-aneurysmal thrombus. This excludes the aneurysm from the parent artery and returns the flow of blood to normal. Previous flow diverting devices have been analyzed to determine optimal characteristics, such as braiding angle and wire diameter. From this information, a new optimized device was designed to achieve equivalent hemodynamic performance to the previous best device, but with better longitudinal flexibility to preserve physiological arterial configuration. The new device was tested in vitro in an elastomeric replica of the rabbit elastase induced aneurysm model and is now in the process of being tested in vivo. Particle image velocimetry was utilized to determine the velocity field in the plane of symmetry of the model under pulsatile flow conditions. Device hemodynamic performance indices such as the hydrodynamic circulation were evaluated from the velocity fields. Comparison of these indices with the previous best device and a control shows that the significant design changes of the device did not change its hemodynamic attributes (p > 0.05).
authors.affiliation: Department of Biomedical Engineering, University of Miami, Coral Gables, FL 33146, USA.
authors.forename: Asher L
authors.initials: AL
authors.lastname: Trager
authors.forename: Chander
authors.initials: C
authors.lastname: Sadasivan
authors.forename: Baruch B
authors.initials: BB
authors.lastname: Lieber
mesh_terms: D000818:Animals; D004548:Elasticity; D006439:Hemodynamics; D002532:Intracranial Aneurysm / Q000503:physiopathology* / Q000601:surgery*; D016062:Porosity; D011817:Rabbits; D058017:Vascular Grafting / Q000295:instrumentation*