title: The relationship between large cavum septum pellucidum and antisocial behavior, callous-unemotional traits and psychopathy in adolescents.
abstract: BACKGROUND
  The presence of a large cavum septum pellucidum (CSP) has been previously associated with antisocial behavior/psychopathic traits in an adult community sample.
  
  
  OBJECTIVE
  The current study investigated the relationship between a large CSP and symptom severity in disruptive behavior disorders (DBD; conduct disorder and oppositional defiant disorder).
  
  
  METHODS
  Structural MRI scans of youth with DBDs (N = 32) and healthy comparison youth (N = 27) were examined for the presence of a large CSP and if this was related to symptom severity.
  
  
  RESULTS
  Replicating previous results, a large CSP was associated with DBD diagnosis, proactive aggression, and level of psychopathic traits in youth. However, the presence of a large CSP was unrelated to aggression or psychopathic traits within the DBD sample.
  
  
  CONCLUSIONS
  Early brain mal-development may increase the risk of a DBD diagnosis, but does not mark a particularly severe form of DBD within patients receiving these diagnoses.
authors.affiliation: Unit on Affective Cognitive Neuroscience, National Institute of Mental Health, NIH, Bethesda, MD, USA. whitesf@mail.nih.gov
authors.forename: Stuart F
authors.initials: SF
authors.lastname: White
authors.forename: Sarah
authors.initials: S
authors.lastname: Brislin
authors.forename: Stephen
authors.initials: S
authors.lastname: Sinclair
authors.forename: Katherine A
authors.initials: KA
authors.lastname: Fowler
authors.forename: Kayla
authors.initials: K
authors.lastname: Pope
authors.forename: R James R
authors.initials: RJ
authors.lastname: Blair
mesh_terms: D000374:Aggression / Q000502:physiology; D000987:Antisocial Personality Disorder / Q000175:diagnosis* / Q000503:physiopathology / Q000523:psychology; D019958:Attention Deficit and Disruptive Behavior Disorders / Q000175:diagnosis* / Q000503:physiopathology / Q000523:psychology; D019955:Conduct Disorder / Q000175:diagnosis* / Q000503:physiopathology / Q000523:psychology; D004645:Empathy / Q000502:physiology*; D006801:Humans; D007090:Image Interpretation, Computer-Assisted; D008279:Magnetic Resonance Imaging; D009929:Organ Size / Q000502:physiology; D010552:Personality Assessment / Q000706:statistics & numerical data; D010555:Personality Inventory / Q000706:statistics & numerical data; D011594:Psychometrics; D012016:Reference Values; D012307:Risk Factors; D012688:Septum Pellucidum / Q000473:pathology* / Q000503:physiopathology; D013223:Statistics as Topic