title: The synthesis, structural study and anticancer activity evaluation of emodin derivatives containing conjugative groups.
abstract: Eight new emodin derivatives that contain large conjugative system have been synthesized and their anticancer activities also have been evaluated. The result shows that large conjugative system can not enhance the anticancer activities of emodin derivatives, but the introduction of an alkylating center can make emodin derivative effective against cancer cell lines. Compound 12 has the highest alkylating ability, but its anticancer activity is not remarkable, which indicates that there is not a direct correlation between the chemical reactivity of the alkylating agent and the toxic effects.
authors.affiliation: College of Chemistry and Chemical Engineering, Fuzhou University, Fujian, 350108, P. R. China. wangwf@fzu.edu.cn
authors.forename: Wang
authors.initials: W
authors.lastname: Wen-Feng
authors.forename: Zhang
authors.initials: Z
authors.lastname: Feng-Sen
authors.forename: Zhao
authors.initials: Z
authors.lastname: Wen-Na
authors.forename: Bai
authors.initials: B
authors.lastname: Ze-Dong
authors.forename: Yang
authors.initials: Y
authors.lastname: Hui-Jun
authors.forename: Shao
authors.initials: S
authors.lastname: Jing-Wei
authors.forename: Yuan
authors.initials: Y
authors.lastname: Yao-Feng
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D018906:Antineoplastic Agents, Alkylating / Q000138:chemical synthesis / Q000494:pharmacology; D049109:Cell Proliferation / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D004354:Drug Screening Assays, Antitumor; D004642:Emodin / Q000031:analogs & derivatives* / Q000138:chemical synthesis* / Q000494:pharmacology; D006801:Humans; D013329:Structure-Activity Relationship; D014407:Tumor Cells, Cultured
chemical_list: D000970:Antineoplastic Agents; D018906:Antineoplastic Agents, Alkylating; D004642:Emodin