title: Total syntheses of amphidinolides B, G, and H.
abstract: Not one, not two, but three: Total syntheses of amphidinolides B, G, and H, which exhibit strong, nanogram-scale cytotoxicity against various tumor cell lines, have been executed. The synthetic strategy relied on implementation of a diene construction protocol and a diastereoselective aldol process. The 26- and 27-membered macrocyclic lactone rings were efficiently constructed by using ring-closing metathesis (RCM).
authors.affiliation: Department of Chemistry, Faculty of Science and Technology, Keio University, Yokohama, Kanagawa, Japan.
authors.forename: Akihiro
authors.initials: A
authors.lastname: Hara
authors.forename: Ryo
authors.initials: R
authors.lastname: Morimoto
authors.forename: Yuki
authors.initials: Y
authors.lastname: Iwasaki
authors.forename: Tsuyoshi
authors.initials: T
authors.lastname: Saitoh
authors.forename: Yuichi
authors.initials: Y
authors.lastname: Ishikawa
authors.forename: Shigeru
authors.initials: S
authors.lastname: Nishiyama
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis*; D001688:Biological Products / Q000138:chemical synthesis*; D019086:Bridged Bicyclo Compounds, Heterocyclic / Q000138:chemical synthesis*; D018942:Macrolides / Q000138:chemical synthesis*; D000097442:Amphidinolides
chemical_list: D000970:Antineoplastic Agents; D001688:Biological Products; D019086:Bridged Bicyclo Compounds, Heterocyclic; D018942:Macrolides; C414663:amphidinolide G; D000097442:Amphidinolides; C414664:amphidinolide H; C062197:amphidinolide D