title: Asymmetric Michael additions of α-nitrocyclohexanone to aryl nitroalkenes catalyzed by natural amino acid-derived bifunctional thioureas.
abstract: A series of new thiourea catalysts prepared from natural amino acids have been applied in organocatalytic asymmetric Michael additions of α-nitrocyclohexanone to nitroalkenes. The resulting addition products are formed with excellent enantioselectivities (up to an er of 98:2) in good yields (up to 90%).
authors.affiliation: Institute of Organic Chemistry, RWTH Aachen University, Landoltweg1, D-52074 Aachen, Germany.
authors.forename: Manuel
authors.initials: M
authors.lastname: Jörres
authors.forename: Ingo
authors.initials: I
authors.lastname: Schiffers
authors.forename: Iuliana
authors.initials: I
authors.lastname: Atodiresei
authors.forename: Carsten
authors.initials: C
authors.lastname: Bolm
mesh_terms: D000475:Alkenes / Q000737:chemistry*; D000596:Amino Acids / Q000737:chemistry*; D001224:Aspartic Acid / Q000737:chemistry; D002384:Catalysis; D018698:Glutamic Acid / Q000737:chemistry; D015394:Molecular Structure; D009574:Nitro Compounds / Q000138:chemical synthesis* / Q000737:chemistry*; D010880:Piperidines / Q000737:chemistry; D011759:Pyrrolidines / Q000737:chemistry; D013237:Stereoisomerism; D013890:Thiourea / Q000138:chemical synthesis / Q000737:chemistry*
chemical_list: D000475:Alkenes; D000596:Amino Acids; D009574:Nitro Compounds; D010880:Piperidines; D011759:Pyrrolidines; D001224:Aspartic Acid; D018698:Glutamic Acid; D013890:Thiourea