title: Complex gadolinium-oxo clusters formed along concave protein surfaces.
abstract: Protein-bound contrast: The unusual observation of a heptanuclear gadolinium-oxo cluster on the surface of the cell-adhesion protein Flo5A establishes the basis for directed incorporation of poly-lanthanide clusters into biomolecules. The observed gadolinium cluster might serve as a paradigm for the design of protein-based MRI contrast agents.
authors.affiliation: Fachbereich Chemie, Philipps-Universität Marburg, Hans-Meerwein-Strasse, 35043 Marburg, Germany.
authors.forename: Maik
authors.initials: M
authors.lastname: Veelders
authors.forename: Lars-Oliver
authors.initials: LO
authors.lastname: Essen
mesh_terms: D001665:Binding Sites; D003287:Contrast Media / Q000737:chemistry*; D005682:Gadolinium / Q000737:chemistry*; D037102:Lectins / Q000032:analysis*; D008279:Magnetic Resonance Imaging; D008958:Models, Molecular; D017434:Protein Structure, Tertiary; D012441:Saccharomyces cerevisiae / Q000737:chemistry*; D029701:Saccharomyces cerevisiae Proteins / Q000032:analysis*; D014961:X-Ray Diffraction
chemical_list: D003287:Contrast Media; C103472:FLO5 protein, S cerevisiae; D037102:Lectins; D029701:Saccharomyces cerevisiae Proteins; D005682:Gadolinium