title: [Demyelinating polyneuropathies in patients with diabetes mellitus and chronic alcoholic intoxication].
abstract: Frequency and nosological attribution of demyelinating polyneuropathies in patients with diabetes mellitus and alcoholism were determined. Eighty-six inpatients with alcoholic (n=46) and diabetic (n=40) polyneuropathy were examined clinically and using electroneuromyography (ENMG). A demyelinating pathogenetic variant was identified by clinical and ENMG data in 27 (31%) patients. Nine patients (33%) had dysimmune polyneuropathies (acute and chronic inflammatory demyelinating polyneuropathy). Polyneuropathies were specified as toxic/metabolic with the prevalence of a demyelinating component within the main disease in 18 (67%) patients. Clinical and ENMG-signs of the demyelinating variant of alcoholic and diabetic neuropathy are presented. The efficacy of the antioxidant berlition was shown for toxic/metabolic polyneuropathies while the addition of immune modulators was needed for treatment of dysimmune polyneuropathy.
authors.forename: E A
authors.initials: EA
authors.lastname: Kovrazhkina
mesh_terms: D000208:Acute Disease; D000437:Alcoholism / Q000150:complications*; D000975:Antioxidants / Q000627:therapeutic use; D003928:Diabetic Nephropathies / Q000145:classification* / Q000175:diagnosis* / Q000188:drug therapy / Q000209:etiology; D004576:Electromyography; D006801:Humans; D011115:Polyneuropathies / Q000145:classification* / Q000175:diagnosis* / Q000188:drug therapy / Q000209:etiology; D020277:Polyradiculoneuropathy, Chronic Inflammatory Demyelinating / Q000145:classification* / Q000175:diagnosis* / Q000188:drug therapy / Q000209:etiology; D008063:Thioctic Acid / Q000627:therapeutic use
chemical_list: D000975:Antioxidants; D008063:Thioctic Acid; C532845:berlition