title: New abietane norditerpenoid from Salvia miltiorrhiza with cytotoxic activities.
abstract: One new abietane-type norditerpenoid, named militibetin A (1), was isolated from the dry roots of Salvia miltiorrhiza, along with two known diterpenoids, yunnannin A (2) and ferruginol (3). Their structures were established by means of extensive spectroscopic analyses. In vitro, compounds 1-3 were found to show cytotoxicities against selected cancer cells, including P-388, HONE-1, and HT-29, and gave ED(50) values in the range of 2.9-5.4 μg ml(- 1).
authors.affiliation: School of Pharmaceutical Science, Yantai University, Yantai, China.
authors.forename: Fang
authors.initials: F
authors.lastname: Yao
authors.forename: De-Wu
authors.initials: DW
authors.lastname: Zhang
authors.forename: Gui-Wu
authors.initials: GW
authors.lastname: Qu
authors.forename: Gui-Sheng
authors.initials: GS
authors.lastname: Li
authors.forename: Sheng Jun
authors.initials: SJ
authors.lastname: Dai
mesh_terms: D045784:Abietanes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D004354:Drug Screening Assays, Antitumor; D019073:HT29 Cells; D006801:Humans; D007941:Leukemia P388; D051379:Mice; D015394:Molecular Structure; D018517:Plant Roots / Q000737:chemistry; D027561:Salvia miltiorrhiza / Q000737:chemistry*
chemical_list: D045784:Abietanes; D000972:Antineoplastic Agents, Phytogenic; C431074:ferruginol; C576792:militibetin A