title: Melanogenesis inhibition by homoisoflavavone sappanone A from Caesalpinia sappan.
abstract: Homoisoflavanone, sappanone A, was isolated from Caesalpinia sappan and proven to dose-dependently inhibit both melanogenesis and cellular tyrosinase activity via repressing tyrosinase gene expression in mouse B16 melanoma cells. To our knowledge, sappanone A is the first homoisoflavanone to be discovered with melanogenesis inhibitory activity. Our results give a new impetus to the future search for other homoisoflavanone melanogenesis inhibitors.
authors.affiliation: Department of Biological Sciences and Technology, National University of Tainan, 33 sec. 2 Su-Lin St., Tainan 700, Taiwan.
authors.forename: Te-Sheng
authors.initials: TS
authors.lastname: Chang
authors.affiliation: Department of Biological Sciences and Technology, National University of Tainan, 33 sec. 2 Su-Lin St., Tainan 700, Taiwan.
authors.forename: Shih-Yu
authors.initials: SY
authors.lastname: Chao
authors.affiliation: Institute of Cosmetics Science, Chia Nan University of Pharmacy and Science, 60 sec. 1 Erh-Jen RD, Jen-Te, Tainan 717, Taiwan.
authors.forename: Hsiou-Yu
authors.initials: HY
authors.lastname: Ding
mesh_terms: D000818:Animals; D029911:Caesalpinia / Q000737:chemistry*; D049109:Cell Proliferation / Q000187:drug effects; D004791:Enzyme Inhibitors / Q000494:pharmacology*; D007529:Isoflavones / Q000494:pharmacology*; D008543:Melanins / Q000096:biosynthesis*; D008546:Melanoma, Experimental / Q000188:drug therapy / Q000473:pathology*; D051379:Mice; D014442:Monophenol Monooxygenase / Q000037:antagonists & inhibitors / Q000235:genetics / Q000378:metabolism; D010936:Plant Extracts / Q000494:pharmacology*; D012333:RNA, Messenger / Q000235:genetics; D060888:Real-Time Polymerase Chain Reaction; D020133:Reverse Transcriptase Polymerase Chain Reaction
chemical_list: D004791:Enzyme Inhibitors; D007529:Isoflavones; D008543:Melanins; D010936:Plant Extracts; D012333:RNA, Messenger; C000601074:sappanone A; D014442:Monophenol Monooxygenase