title: [Quantitative assessment of left ventricular systolic dyssynchrony in relation to systolic function by real-time three-dimensional echocardiography-derived regional systolic dyssynchrony index in chronic heart failure patients].
abstract: OBJECTIVE
  To quantitatively assess the left ventricular systolic dyssynchrony in patients with chronic heart failure based on the regional systolic dyssynchrony index (R-SDI) derived from real-time three-dimensional echocardiography (RT-3DE), and investigate the relation between R-SDI and the left ventricular systolic function.
  
  
  METHODS
  Forty-two patients with chronic heart failure (LVEF<50%) were classified into severe dysfunction group (group A, LVEF<40%) and mild dysfunction group (group B, LVEF≥40%), with 33 healthy subjects as the control group (LVEF>50%). RT-3DE was performed for each subject to obtain the left volume-time curves and the 16, 12, and 6 segment R-SDI. The value of R-SDI in assessing left ventricular systolic dyssynchrony and its correlation with LVEF were analyzed.
  
  
  RESULTS
  The 16, 12, and 6R-SDI were significantly higher in the chronic heart failure group than in the control group (P<0.01). The R-SDI of group A was significantly greater than those of group B in the chronic heart failure patients (P<0.01), and 16R-SDI, 12R-SDI, and 6R-SDI were inversely correlated with LVEF of the patients (r=-0.843, -0.840, and -0.841, respectively, P<0.01).
  
  
  CONCLUSIONS
  R-SDI can be used to assess the left ventricular mechanic systolic dyssynchrony, and the degree of the dyssynchrony is inversely correlated with LVEF. RT-3DE can serve as a valuable modality for quantitative evaluation of left ventricular dyssynchrony in chronic heart failure patients.
authors.affiliation: Southern Medical University, Guangzhou, China. lbhwuhu@163.com
authors.forename: Biaohu
authors.initials: B
authors.lastname: Liu
authors.forename: Quanshi
authors.initials: Q
authors.lastname: Wang
authors.forename: Xiangming
authors.initials: X
authors.lastname: Zhu
authors.forename: Guojie
authors.initials: G
authors.lastname: Li
authors.forename: Xia
authors.initials: X
authors.lastname: Zhang
mesh_terms: D000328:Adult; D000368:Aged; D016022:Case-Control Studies; D002908:Chronic Disease; D019560:Echocardiography, Three-Dimensional / Q000379:methods*; D005260:Female; D006333:Heart Failure / Q000000981:diagnostic imaging*; D006352:Heart Ventricles / Q000000981:diagnostic imaging; D006801:Humans; D008297:Male; D008875:Middle Aged; D013599:Systole; D018487:Ventricular Dysfunction, Left / Q000000981:diagnostic imaging*; D016277:Ventricular Function, Left