title: Elevated carbohydrate antigen 125 levels in patients with aortic stenosis: relation to clinical severity and echocardiographic parameters.
abstract: OBJECTIVE
  Carbohydrate antigen 125 (CA 125), known as a tumor marker for ovarian cancer, has been reported to increase in relation to disease severity in heart failure patients with systolic dysfunction. Aortic stenosis (AS) has a wide clinical spectrum that often includes heart failure symptoms. The purpose of the present study is to evaluate the serum levels of CA 125 in patients with AS and its relation to clinical severity and echocardiographic parameters.
  
  
  METHODS
  The study group consisted of 42 patients (20 males, 22 females, mean age 62.5 ± 14.9 years) with AS and 35 healthy controls (17 men, 18 women; mean age 59.0 ± 9.1 years). All patients and control subjects underwent chest X-ray and echocardiographic evaluation. We measured serum CA 125 values in patients with AS and control subjects.
  
  
  RESULTS
  The median (interquartile range) CA 125 level was significantly higher among AS patients than in the control group in covariate analysis (9.4 [2.5-38.1] vs. 6.8 [4.4-13.9] U/ml respectively; p=0.001). Spearman correlation analysis in the whole group indicated that CA 125 was positively correlated with aortic mean gradient (p=0.007, r=0.30) and creatinine levels (p=0.02, r=0.26).
  
  
  CONCLUSIONS
  We found that CA 125 levels were elevated in patients with AS and were correlated with mean gradient and creatinine levels.
authors.affiliation: Department of Cardiology, Süleyman Demirel University Faculty of Medicine, Isparta, Turkey. drercanvarol@yahoo.com
authors.forename: Ercan
authors.initials: E
authors.lastname: Varol
authors.forename: Habil
authors.initials: H
authors.lastname: Yücel
authors.forename: Akif
authors.initials: A
authors.lastname: Arslan
authors.forename: Mehmet
authors.initials: M
authors.lastname: Ozaydın
authors.forename: Doğan
authors.initials: D
authors.lastname: Erdoğan
authors.forename: Abdullah
authors.initials: A
authors.lastname: Doğan
mesh_terms: D000368:Aged; D000704:Analysis of Variance; D001024:Aortic Valve Stenosis / Q000097:blood / Q000175:diagnosis* / Q000000981:diagnostic imaging; D018394:CA-125 Antigen / Q000097:blood*; D016022:Case-Control Studies; D004452:Echocardiography; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012720:Severity of Illness Index
chemical_list: D018394:CA-125 Antigen