title: Further findings linking SSRIs during pregnancy and persistent pulmonary hypertension of the newborn: clinical implications.
abstract: Persistent pulmonary hypertension of the newborn (PPHN) is a rare but potentially life-threatening neonatal condition. Several authors have suggested that late pregnancy exposure to selective serotonin reuptake inhibitors (SSRIs) may increase the risk of PPHN. This association has been investigated in seven published studies that have shown mixed findings based on diverse methods. Several methodological limitations may account for the diversity of findings, which include, in some studies, a lack of control for well established risk factors for PPHN. The methodological improvement in the most recent study tentatively suggests that infants prenatally exposed to SSRIs are approximately twice as likely to suffer PPHN. Further research on the biological mechanisms involved is required. Clinicians should consider late pregnancy exposure to SSRIs as one of several possible risks for PPHN, which has implications for both prescribing SSRIs to pregnant women and for neonatal care of SSRI-exposed infants.
authors.affiliation: Perinatal Mental Health Unit, Mercy Hospital for Women, Heidelberg, VIC, Australia. mgalbally@mercy.com.au
authors.forename: Megan
authors.initials: M
authors.lastname: Galbally
authors.forename: Salvatore
authors.initials: S
authors.lastname: Gentile
authors.forename: Andrew J
authors.initials: AJ
authors.lastname: Lewis
mesh_terms: D005260:Female; D006801:Humans; D006976:Hypertension, Pulmonary / Q000139:chemically induced*; D007231:Infant, Newborn; D010547:Persistent Fetal Circulation Syndrome / Q000139:chemically induced*; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects / Q000139:chemically induced*; D012307:Risk Factors; D017367:Selective Serotonin Reuptake Inhibitors / Q000009:adverse effects*
chemical_list: D017367:Selective Serotonin Reuptake Inhibitors