title: Enantioselective oxidation of aldehydes catalyzed by alcohol dehydrogenase.
abstract: Teaching old dogs new tricks: Alcohol dehydrogenases (ADHs) may be established redox biocatalysts but they still are good for a few surprises. ADHs can be used to oxidize aldehydes, and this was demonstrated by the oxidative dynamic kinetic resolution of profens. In the presence of a suitable cofactor regeneration system, this reaction can occur with high selectivity.
authors.affiliation: Department of Biotechnology, Delft University of Technology, Delft, The Netherlands.
authors.forename: Paul
authors.initials: P
authors.lastname: Könst
authors.forename: Hedda
authors.initials: H
authors.lastname: Merkens
authors.forename: Selin
authors.initials: S
authors.lastname: Kara
authors.forename: Svenja
authors.initials: S
authors.lastname: Kochius
authors.forename: Andreas
authors.initials: A
authors.lastname: Vogel
authors.forename: Ralf
authors.initials: R
authors.lastname: Zuhse
authors.forename: Dirk
authors.initials: D
authors.lastname: Holtmann
authors.forename: Isabel W C E
authors.initials: IW
authors.lastname: Arends
authors.forename: Frank
authors.initials: F
authors.lastname: Hollmann
mesh_terms: D000426:Alcohol Dehydrogenase / Q000235:genetics / Q000378:metabolism*; D000438:Alcohols / Q000378:metabolism; D000447:Aldehydes / Q000378:metabolism*; D004926:Escherichia coli / Q000201:enzymology* / Q000235:genetics; D007700:Kinetics; D007778:Lactobacillus / Q000201:enzymology; D010084:Oxidation-Reduction; D011994:Recombinant Proteins / Q000235:genetics / Q000378:metabolism; D013237:Stereoisomerism
chemical_list: D000438:Alcohols; D000447:Aldehydes; D011994:Recombinant Proteins; D000426:Alcohol Dehydrogenase