title: [The use of laser Doppler flowmetry for the estimation of the influence of intranasal medications on microcirculation in nasal cavity mucosa].
abstract: OBJECTIVE
  to investigate the influence of various intranasal medications on the microcirculatory bed in nasal cavity mucosa using the original method of laser Doppler flowmetry.
  
  
  METHODS
  this comprehensive study of the influence of intranasal medicines on nasal cavity mucosa using laser Doppler flowmetry was designed to evaluate the mucociliary clearance, breathing efficiency of the nose, and subjective symptoms of its impairment. The outcomes of a single application of intranasal medications were estimated in 90 rhinologically healthy subjects; in 15 of them, the micrcirculatory blood flow in the nasal cavity was investigated in the early postoperative period with the use of intranasal decongestants and irrigation products.
  
  
  RESULTS
  this study has demonstrated the relationship between the changes in the microcirculatory bed and the application of intranasal medications acting on nasal mucosa. Moreover, these agents were shown to affect intranasal mucosa and its microcirculatory bed following rhinological surgical interventions. Tachyphylaxis of the microcirculatory bed after the administration of the decongestants developed earlier than previously thought. At the came time, irrigation therapy exerted the beneficial effect on the state of the intranasal microcirculatory bed in the postoperative period.
authors.forename: A A
authors.initials: AA
authors.lastname: Svistunov
authors.forename: O V
authors.initials: OV
authors.lastname: Mareev
authors.forename: G O
authors.initials: GO
authors.lastname: Mareev
authors.forename: I S
authors.initials: IS
authors.lastname: Bukreev
mesh_terms: D000281:Administration, Intranasal / Q000009:adverse effects; D000328:Adult; D005260:Female; D006801:Humans; D017078:Laser-Doppler Flowmetry / Q000379:methods*; D008297:Male; D055806:Microvessels / Q000187:drug effects*; D014663:Nasal Decongestants / Q000008:administration & dosage / Q000009:adverse effects; D055556:Nasal Lavage / Q000009:adverse effects; D009297:Nasal Mucosa / Q000098:blood supply* / Q000502:physiology; D012039:Regional Blood Flow / Q000187:drug effects; D018570:Risk Assessment; D016896:Treatment Outcome
chemical_list: D014663:Nasal Decongestants