title: Organocatalytic enantioselective one-pot four-component ugi-type multicomponent reaction for the synthesis of epoxy-tetrahydropyrrolo[3,4-b]pyridin-5-ones.
abstract: Enantioselective multicomponent reaction: in the presence of a catalytic amount of chiral BINOL-derived phosphoric acid (TRIP), the reaction of an α-isocyanoacetate 1, an aldehyde 2, and an aniline 3, followed by addition of a toluene solution of α,β-unsaturated acyl chloride 4 afforded the oxa-bridged tricycle 5 in excellent yield, diastereoselectivity, and enantioselectivity. Six chemical bonds, five stereogenic centers, and three cycles were formed in this one-pot four-component reaction.
authors.affiliation: Institut de Chimie des Substances Naturelles, CNRS, Gif-sur-Yvette, France.
authors.forename: Yingpeng
authors.initials: Y
authors.lastname: Su
authors.forename: Marinus J
authors.initials: MJ
authors.lastname: Bouma
authors.forename: Lilian
authors.initials: L
authors.lastname: Alcaraz
authors.forename: Mike
authors.initials: M
authors.lastname: Stocks
authors.forename: Mark
authors.initials: M
authors.lastname: Furber
authors.forename: Géraldine
authors.initials: G
authors.lastname: Masson
authors.forename: Jieping
authors.initials: J
authors.lastname: Zhu