title: [Surgical outcome and prognostic factors in focal cortical dysplasia with intractable epilepsy].
abstract: OBJECTIVE
  To analyze surgical outcome and relevant surgical parameters including resection extent of epileptogenic zone,pathological subtype, brain MRS and MRI results in FCD with intractable epilepsy.
  
  
  METHODS
  We retrospectively analyzed surgical outcomes of 35 patients with intractable epilepsy related to focal cortical dysplasia, accepted surgery in the first affiliated hospital of Fujian Medical University from January 2008 to January 2010, with 12-36 months of postoperative follow-up. The relevance between complete resection, pathological subtype, MRS and MRI result and surgical outcome were statistically evaluated.
  
  
  RESULTS
  22 patients (66.7%) were Engel class I, 5 patients (14.3%) were class II, 6 patients (17.2%) were class III, 2 patients (5.8%) were class IV. Complete resection of epileptogenic zone (P < 0.05), FCD type I (P < 0.05) correlated significantly with favorable surgical outcome. Other factors such as MRI results, abnormal NAA/CHO + Cr ratio on the contralateral side of epileptogenic zone, as well as MRS-accurate lateralization did not influence outcome.
  
  
  CONCLUSIONS
  Overall, the surgical outcome of FCD is favorable. Complete resection, FCD type I correlates significantly with favorable surgical outcome.
authors.affiliation: Department of Neurosurgery, the First Affiliated Hospital of Fujian Medical University, Fuzhou 350005, China.
authors.forename: Yuan-xiang
authors.initials: YX
authors.lastname: Lin
authors.forename: Kun
authors.initials: K
authors.lastname: Lin
authors.forename: De-zhi
authors.initials: DZ
authors.lastname: Kang
authors.forename: Zhang-ya
authors.initials: ZY
authors.lastname: Lin
authors.forename: Xiao-fen
authors.initials: XF
authors.lastname: Huang
authors.forename: Feng
authors.initials: F
authors.lastname: Wang
authors.forename: Liang-hong
authors.initials: LH
authors.lastname: Yu
authors.forename: Fu-yong
authors.initials: FY
authors.lastname: Chen
mesh_terms: D000293:Adolescent; D000328:Adult; D002648:Child; D002675:Child, Preschool; D004827:Epilepsy / Q000209:etiology / Q000473:pathology / Q000601:surgery*; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D054220:Malformations of Cortical Development / Q000150:complications / Q000473:pathology / Q000601:surgery*; D012189:Retrospective Studies; D016896:Treatment Outcome; D055815:Young Adult