title: Short communication: NKG2C+ NK cells contribute to increases in CD16+CD56- cells in HIV type 1+ individuals with high plasma viral load.
abstract: Chronic HIV-1 infection results in the expansion of both NKG2C+ and CD16+CD56- human natural killer cells. NKG2C+ cells proliferate in response to human cytomegalovirus (HCMV) and expansion of the dysfunctional CD56-CD16+ natural killer (NK) cells is associated with HIV-1 viremia. Here we report an association between increased proportions of CD56-CD16+ NK cells in viremic HIV-1+ individuals and an increased contribution of NKG2C+ cells to this subset. These data, in addition to anti-HCMV IgG serology, indicate a potential contribution of both HCMV and HIV-1 to NK cell dysfunction in HIV-1-infected individuals.
authors.affiliation: Department of Immunology, Imperial College London, Chelsea and Westminster Hospital, London, United Kingdom.
authors.forename: John N S
authors.initials: JN
authors.lastname: Gregson
authors.forename: Leticia
authors.initials: L
authors.lastname: Kuri-Cervantes
authors.forename: Christopher M
authors.initials: CM
authors.lastname: Mela
authors.forename: Brian G
authors.initials: BG
authors.lastname: Gazzard
authors.forename: Mark
authors.initials: M
authors.lastname: Bower
authors.forename: Martin R
authors.initials: MR
authors.lastname: Goodier
mesh_terms: D000328:Adult; D000368:Aged; D019002:CD56 Antigen / Q000276:immunology*; D015658:HIV Infections / Q000276:immunology*; D015497:HIV-1 / Q000276:immunology*; D006801:Humans; D007694:Killer Cells, Natural / Q000276:immunology*; D016131:Lymphocyte Subsets / Q000276:immunology; D008875:Middle Aged; D055654:NK Cell Lectin-Like Receptor Subfamily C / Q000276:immunology*; D017452:Receptors, IgG / Q000276:immunology*; D019562:Viral Load / Q000276:immunology*; D055815:Young Adult
chemical_list: D019002:CD56 Antigen; C522918:NCAM1 protein, human; D055654:NK Cell Lectin-Like Receptor Subfamily C; D017452:Receptors, IgG