title: Red man syndrome adverse reaction following intravenous infusion of cefepime.
abstract: We report the first case of cefepime-induced "red-man syndrome," which appeared 30 min following drug infusion and was confirmed with a rechallenge test. This syndrome is classically associated with vancomycin infusion and is the result of non-IgE mediated mast cell degranulation. While this adverse effect can be easily managed with drug withdrawal and antihistamine administration, it is unknown whether it can be prevented with slower cefepime infusion and preinfusion antihistamines, as is the case with vancomycin.
authors.affiliation: Department of Internal Medicine, Patras University General Hospital, Greece. panmedix@otenet.gr
authors.forename: George
authors.initials: G
authors.lastname: Panos
authors.forename: Dionysios C
authors.initials: DC
authors.lastname: Watson
authors.forename: Maria
authors.initials: M
authors.lastname: Sargianou
authors.forename: Dionysios
authors.initials: D
authors.lastname: Kampiotis
authors.forename: Paraskevi
authors.initials: P
authors.lastname: Chra
mesh_terms: D000328:Adult; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D000077723:Cefepime; D002511:Cephalosporins / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D004342:Drug Hypersensitivity / Q000503:physiopathology*; D004890:Erythema / Q000139:chemically induced*; D006633:Histamine Antagonists / Q000627:therapeutic use; D006801:Humans; D007262:Infusions, Intravenous; D008297:Male; D008590:Meningoencephalitis / Q000150:complications / Q000188:drug therapy; D011537:Pruritus / Q000139:chemically induced; D012867:Skin / Q000473:pathology
chemical_list: D000900:Anti-Bacterial Agents; D002511:Cephalosporins; D006633:Histamine Antagonists; D000077723:Cefepime