title: Exploring converse molecular mechanisms of anti-HIV-1 antibodies using a synthetic CXCR4 mimic.
abstract: Different molecular mechanisms of the two broadly neutralizing anti-HIV-1 antibodies b12 and VRC01, as evidenced by their converse effects on the interaction of HIV-1 envelope glycoprotein gp120 with cellular coreceptors, were demonstrated using a synthetic CXCR4 mimetic peptide (CX4-M1) as coreceptor surrogate. While the interaction of gp120 with CX4-M1 was distinctly enhanced by VRC01, b12 was shown to have the contrary effect, and also to inhibit the VRC01-induced enhancement of gp120 binding to the CXCR4 mimetic peptide.
authors.affiliation: Department of Chemistry and Pharmacy, University of Erlangen-Nürnberg, 91052 Erlangen, Germany.
authors.forename: Christina
authors.initials: C
authors.lastname: Haussner
authors.forename: Kalle
authors.initials: K
authors.lastname: Möbius
authors.forename: Jutta
authors.initials: J
authors.lastname: Eichler
mesh_terms: D006678:HIV / Q000276:immunology*; D015483:HIV Antibodies / Q000737:chemistry / Q000276:immunology*; D015699:HIV Envelope Protein gp120 / Q000737:chemistry / Q000276:immunology; D008958:Models, Molecular; D018716:Molecular Mimicry / Q000276:immunology*; D010455:Peptides / Q000138:chemical synthesis / Q000737:chemistry / Q000276:immunology*; D019718:Receptors, CXCR4 / Q000276:immunology*
chemical_list: D015483:HIV Antibodies; D015699:HIV Envelope Protein gp120; D010455:Peptides; D019718:Receptors, CXCR4