title: Upregulation of Hsp90-beta and annexin A1 correlates with poor survival and lymphatic metastasis in lung cancer patients.
abstract: BACKGROUND
  Hsp90-beta and annexin A1 were investigated as prognostic factors because of their apparent association with tumorigenesis. However, the effect of Hsp90-beta and annexin A1 in lung cancer remains poorly understood. The expressions of Hsp90-beta and annexin A1 in lung cancer and normal lung specimens were examined, and the relationships with respect to the clinico-pathological features and patient survival in lung cancer were analyzed.
  
  
  METHODS
  The expression levels of Hsp90-beta and annexin A1 were examined using immunohistochemistry, in-situ hybridization, and Western blot.
  
  
  RESULTS
  Lung cancer tissues exhibited higher expression levels of Hsp90-beta and annexin A1 than the normal tissues (p < 0.05), and the expression levels of the markers were significantly associated with the pathological grade and lymphatic invasion of lung cancer (p < 0.05). Moreover, the upregulation of Hsp90-beta and annexin A1 correlated with decreased survival (p < 0.05).
  
  
  CONCLUSIONS
  The upregulation of Hsp90-beta and annexin A1 were associated with poor post-surgical survival time and lymphatic metastasis of lung cancer patients. Moreover, the high expression of the markers was an independent predictor of poor outcomes.
authors.affiliation: Department of Respiratory Medicine, Second Affiliated Hospital, Xi'an Jiaotong University, 157, Xi 5 Road, Xi'an 710004, People's Republic of China.
authors.forename: Rong
authors.initials: R
authors.lastname: Biaoxue
authors.forename: Jiang
authors.initials: J
authors.lastname: Xiling
authors.forename: Yang
authors.initials: Y
authors.lastname: Shuanying
authors.forename: Zhang
authors.initials: Z
authors.lastname: Wei
authors.forename: Cai
authors.initials: C
authors.lastname: Xiguang
authors.forename: Wang
authors.initials: W
authors.lastname: Jinsui
authors.forename: Zhang
authors.initials: Z
authors.lastname: Min
mesh_terms: D000328:Adult; D000368:Aged; D017305:Annexin A1 / Q000235:genetics*; D045744:Cell Line, Tumor; D005260:Female; D018841:HSP90 Heat-Shock Proteins / Q000235:genetics* / Q000378:metabolism; D006801:Humans; D007150:Immunohistochemistry; D017403:In Situ Hybridization; D008175:Lung Neoplasms / Q000235:genetics* / Q000378:metabolism / Q000473:pathology*; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D016019:Survival Analysis; D015854:Up-Regulation
chemical_list: D017305:Annexin A1; D018841:HSP90 Heat-Shock Proteins; C493165:HSP90AB1 protein, human