title: Role of activity-dependent conduction block in the diagnosis of primary demyelinating polyneuropathy.
abstract: Motor conduction block is one of the well-known neurophysiologic features of primary demyelinating polyneuropathy. In contrast, activity-dependent conduction block (motor conduction block after brief maximum voluntary contraction) is a "rare" neurophysiologic finding in primary demyelinating polyneuropathy. We are reporting the first known case of multifocal acquired demyelinating sensory and motor polyneuropathy with a well-documented activity-dependent conduction block of the ulnar nerve at the forearm segment that transformed into a typical motor response with abnormal temporal dispersion.
authors.affiliation: Department of Neurology, University of Massachusetts Medical Center, Worcester, MA 01605, USA. louis.tramontozzi@gmail.com
authors.forename: Johnny S
authors.initials: JS
authors.lastname: Salameh
authors.forename: Nizar
authors.initials: N
authors.lastname: Souayah
authors.forename: Peter S T
authors.initials: PS
authors.lastname: Chong
mesh_terms: D003711:Demyelinating Diseases / Q000150:complications* / Q000175:diagnosis* / Q000188:drug therapy; D005071:Evoked Potentials / Q000502:physiology; D005500:Follow-Up Studies; D006801:Humans; D016756:Immunoglobulins, Intravenous / Q000494:pharmacology / Q000627:therapeutic use; D007155:Immunologic Factors / Q000494:pharmacology / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D009431:Neural Conduction / Q000187:drug effects / Q000502:physiology*; D011115:Polyneuropathies / Q000150:complications* / Q000175:diagnosis* / Q000188:drug therapy; D014459:Ulnar Nerve / Q000187:drug effects / Q000503:physiopathology
chemical_list: D016756:Immunoglobulins, Intravenous; D007155:Immunologic Factors