title: Waist circumference as a predictor of adiponectin levels in peritoneal dialysis patients: a 12-month follow-up study.
abstract: OBJECTIVE
  This prospective study, conducted at the dialysis unit of the Nephrology Division, Federal University of Sao Paulo-Oswaldo Ramos Foundation, Brazil, aimed to evaluate whether waist circumference (WC) can predict adiponectin levels in patients undergoing peritoneal dialysis (PD).
  
  
  METHODS
  Among 115 patients on PD at a single dialysis center who were evaluated at 6 and 12 months, 57% were men, 31% had diabetes, mean age was 52.8 ± 16.1 years, body mass index was 25 ± 4.3 kg/m(2), and dialysis vintage was 13 months (range: 5 - 33 months). We measured WC at the umbilicus level. Adiponectin was determined by an enzyme-linked immunosorbent assay.
  
  
  RESULTS
  At baseline, WC was inversely associated with adiponectin (r = -0.48, p < 0.01). After adjustment for sex, age, diabetes, peritoneal clearance, and residual renal function, WC was an independent determinant of serum adiponectin (β = -0.52; 95% confidence interval: -0.73 to -0.31; p < 0.001). In the prospective analysis, after adjustment for confounders, changes in WC predicted changes in adiponectin. For each unit increase in WC, adiponectin declined by 0.39 mg/L (p < 0.001).
  
  
  CONCLUSIONS
  This study demonstrates that WC is associated with adiponectin and, more importantly, that this simple marker of central adiposity was able to predict changes in adiponectin levels over time.
authors.affiliation: Nutrition Program, Federal University of São Paulo, São Paulo, Brazil.
authors.forename: Ana Paula
authors.initials: AP
authors.lastname: Bazanelli
authors.forename: Maria Ayako
authors.initials: MA
authors.lastname: Kamimura
authors.forename: Maria Eugenia Fernandes
authors.initials: ME
authors.lastname: Canziani
authors.forename: Silvia Regina
authors.initials: SR
authors.lastname: Manfredi
authors.forename: Lilian
authors.initials: L
authors.lastname: Cuppari
mesh_terms: D050153:Abdominal Fat; D052242:Adiponectin / Q000097:blood*; D050154:Adiposity; D000328:Adult; D000368:Aged; D001938:Brazil; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D010530:Peritoneal Dialysis; D011446:Prospective Studies; D051436:Renal Insufficiency, Chronic / Q000097:blood* / Q000628:therapy*; D013997:Time Factors; D055105:Waist Circumference
chemical_list: D052242:Adiponectin