title: Total synthesis of (+)-Sch 725680: inhibitor of mammalian A-, B-, and Y-family DNA polymerases.
abstract: The total synthesis of (+)-Sch 725680, a member of the hydrogenated azaphilone family, has been accomplished. The synthesis confirmed the absolute configuration and biological activities of the natural product. A key reaction to construct a hydrogenated azaphilone core skeleton is a Ti-mediated aldol reaction.
authors.affiliation: Department of Applied Biological Science, Faculty of Science and Technology, Tokyo University of Science (RIKADAI), Noda-shi, Chiba 278-8510, Japan.
authors.forename: Toshifumi
authors.initials: T
authors.lastname: Takeuchi
authors.forename: Yoshiyuki
authors.initials: Y
authors.lastname: Mizushina
authors.forename: Satoshi
authors.initials: S
authors.lastname: Takaichi
authors.forename: Natsuki
authors.initials: N
authors.lastname: Inoue
authors.forename: Kouji
authors.initials: K
authors.lastname: Kuramochi
authors.forename: Satomi
authors.initials: S
authors.lastname: Shimura
authors.forename: Yusuke
authors.initials: Y
authors.lastname: Myobatake
authors.forename: Yuri
authors.initials: Y
authors.lastname: Katayama
authors.forename: Kenji
authors.initials: K
authors.lastname: Takemoto
authors.forename: Shogo
authors.initials: S
authors.lastname: Endo
authors.forename: Shinji
authors.initials: S
authors.lastname: Kamisuki
authors.forename: Fumio
authors.initials: F
authors.lastname: Sugawara
mesh_terms: D001230:Aspergillus / Q000737:chemistry; D001578:Benzopyrans / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D015394:Molecular Structure; D019384:Nucleic Acid Synthesis Inhibitors; D013237:Stereoisomerism
chemical_list: D001578:Benzopyrans; D019384:Nucleic Acid Synthesis Inhibitors; C517257:Sch 725680