title: Missed opportunities for identifying primary HIV within genitourinary medical/HIV services.
abstract: To assess the ability of three genitourinary medical centres to clinically identify primary HIV infection (PHI). Cases of recently acquired HIV infection, identified using the Health Protection Agency (HPA) avidity assay on all HIV diagnoses from January to August 2009, were investigated by case-note review. Sixty-four individuals were identified as PHI using the HPA avidity assay. Of 64 individuals, 31 (48%) were identified clinically. Imperial College identified 8/26 (31%), Guys and St Thomas' 15/27 (56%) and Brighton 8/11 (73%). Clinical suspicion of PHI was associated with reported unprotected anal intercourse (P = 0.017), seroconversion symptoms (P = 0.0004), a negative HIV test within six months (P = 0.024) and avidity assay result availability (P = 0.0169). Seventy percent of PHI cases missed had a documented risk factor. Thirty-five percent of those clinically identified with PHI were documented as informed of the associated enhanced infectivity. Suspicion of PHI was low despite documented risk factors and recent HIV-negative antibody tests. Counselling to prevent onward transmission was suboptimal.
authors.affiliation: Harrison Wing, Guys and St Thomas' Hospital, Lambeth Palace Road, London SE1 7EH.
authors.forename: K
authors.initials: K
authors.lastname: Sharrocks
authors.forename: C B
authors.initials: CB
authors.lastname: Jones
authors.forename: C
authors.initials: C
authors.lastname: Naftalin
authors.forename: D
authors.initials: D
authors.lastname: Darling
authors.forename: M
authors.initials: M
authors.lastname: Fisher
authors.forename: S
authors.initials: S
authors.lastname: Fidler
authors.forename: J
authors.initials: J
authors.lastname: Fox
mesh_terms: D000328:Adult; D000368:Aged; D003376:Counseling; D005189:False Positive Reactions; D005260:Female; D015658:HIV Infections / Q000517:prevention & control; D006679:HIV Seropositivity / Q000175:diagnosis*; D006801:Humans; D008131:London; D008297:Male; D008875:Middle Aged; D012307:Risk Factors; D047568:Unsafe Sex; D055815:Young Adult