title: Clinicopathological significance and prognostic value of MMP-13 expression in colorectal cancer.
abstract: The purpose of this study was to evaluate the association of matrix metalloproteinase-13 (MMP-13) expression with clinicopathological features and prognosis in colorectal cancer (CRC) patients. CRC tissues and distal normal mucosa tissues of 158 CRC patients were detected by immunohistochemistry. The correlations between MMP-13 expression, the patients' clinicopathological features, and overall survival rate were analyzed. It was found that positive expression rate of MMP-13 in distal normal mucosa tissues was significantly lower than that in CRC tissues (36.7% vs 60.8%, p < 0.001). Poor histological differentiation, advanced clinical stage and lymph node metastasis were significantly correlated with the MMP-13 expression in CRC. The overall survival rate of the MMP-13-negative group was significantly higher than the positive group (Log-rank test = 12.452, p < 0.001). Collectively, we found that MMP-13 was correlated with progression and metastasis of CRC and could be used as a prognostic marker in CRC.
authors.affiliation: Department of Oncology, Wuhan General Hospital of Guangzhou Command PLA, Wuhan, P.R. China.
authors.forename: Bo
authors.initials: B
authors.lastname: Yang
authors.forename: Jianfei
authors.initials: J
authors.lastname: Gao
authors.forename: Zhiguo
authors.initials: Z
authors.lastname: Rao
authors.forename: Qinglin
authors.initials: Q
authors.lastname: Shen
mesh_terms: D000328:Adult; D000368:Aged; D002681:China / Q000453:epidemiology; D015179:Colorectal Neoplasms / Q000201:enzymology* / Q000401:mortality / Q000473:pathology*; D005260:Female; D006801:Humans; D007413:Intestinal Mucosa / Q000201:enzymology / Q000473:pathology; D053208:Kaplan-Meier Estimate; D008297:Male; D053509:Matrix Metalloproteinase 13 / Q000378:metabolism*; D008875:Middle Aged; D015999:Multivariate Analysis; D011379:Prognosis; D016016:Proportional Hazards Models
chemical_list: C507079:MMP13 protein, human; D053509:Matrix Metalloproteinase 13