title: Osteocyte control of osteoclastogenesis.
abstract: Multiple lines of evidence support the idea that osteocytes act as mechanosensors in bone and that they control bone formation, in part, by expressing the Wnt antagonist sclerostin. However, the role of osteocytes in the control of bone resorption has been less clear. Recent studies have demonstrated that osteocytes are the major source of the cytokine RANKL involved in osteoclast formation in cancellous bone. The goal of this review is to discuss these and other studies that reveal mechanisms whereby osteocytes control osteoclast formation and thus bone resorption.
authors.affiliation: Division of Endocrinology and Metabolism, Center for Osteoporosis and Metabolic Bone Diseases, University of Arkansas for Medical Sciences and the Central Arkansas Veterans Healthcare System, Little Rock, AR 72205, USA. caobrien@uams.edu
authors.forename: Charles A
authors.initials: CA
authors.lastname: O'Brien
authors.forename: Tomoki
authors.initials: T
authors.lastname: Nakashima
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Takayanagi
mesh_terms: D000818:Animals; D002454:Cell Differentiation; D006801:Humans; D010010:Osteoclasts / Q000166:cytology / Q000378:metabolism*; D010011:Osteocytes / Q000166:cytology / Q000378:metabolism*; D010012:Osteogenesis; D053245:RANK Ligand / Q000378:metabolism; D015398:Signal Transduction
chemical_list: D053245:RANK Ligand