title: Human papillomavirus infection following radiation therapy or concurrent chemoradiation for invasive cervical cancer.
abstract: OBJECTIVE
  To determine the prevalence of Human Papillomavirus (HPV) infection in patients with invasive cervical cancer after treatment by concurrent chemoradiation therapy.
  
  
  METHODS
  Cervicovaginal mucous samples were collected from fifty-five patients with invasive cervical cancer two months after treatment completion and tested for HPV genotypes.
  
  
  RESULTS
  Of the 55 patients, 31 (56.36%) were found to be positive for HPV among these 25 (45.46%) were positive for high-risk HPV. The most common high-risk HPV found was type 16 which accounted for 35.48% (11/31) of cases. Other high-risk HPV found were types 18 (16.13%), 52 (16.13%) and 58 (12.90%). Follow-up time for patients were 3 to 22 months with mean follow-up of 13 months. In patients positive for high-risk HPV 24.00% (6/25) were found to have persistent or recurrent disease. While 30 patients negative for high-risk HPV 3.33% (1/30) were found to have persistent or recurrent disease.
  
  
  CONCLUSIONS
  The prevalence of HPV infection in cervical cancer patients with positive high-risk HPV after treatment by radiation or concurrent chemoradiation seems to be a risk factor for persistent and recurrent disease. Testing for high-risk HPV may be a useful modality for follow-up of these patients.
authors.affiliation: Gynecologic Oncology Unit, Department of Obstetrics and Gynecology, Phramongkutklao Hospital, Bangkok, Thailand. suttida@pmk.ac.th
authors.forename: Suttida
authors.initials: S
authors.lastname: Intharaburan
authors.forename: Yawana
authors.initials: Y
authors.lastname: Tanapat
authors.forename: Kannika
authors.initials: K
authors.lastname: Tatanan
authors.forename: Kondhee
authors.initials: K
authors.lastname: Sangkhavasi
authors.forename: Sayomporn
authors.initials: S
authors.lastname: Komolpis
authors.forename: Kussathin
authors.initials: K
authors.lastname: Buranawit
authors.forename: Phanida
authors.initials: P
authors.lastname: Jarruwale
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003131:Combined Modality Therapy; D005260:Female; D005838:Genotype; D006801:Humans; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D030361:Papillomavirus Infections / Q000453:epidemiology* / Q000235:genetics; D016133:Polymerase Chain Reaction; D015995:Prevalence; D013785:Thailand / Q000453:epidemiology; D002583:Uterine Cervical Neoplasms / Q000188:drug therapy* / Q000532:radiotherapy* / Q000821:virology