title: [Clarithromycin combined with tanshinone for rhinosinusal and laryngeal radiation injury in patients with nasopharyngeal carcinoma after radiotherapy].
abstract: OBJECTIVE
  To evaluate the therapeutic effect of clarithromycin combined with tanshinone in the treatment of rhinosinusal and laryngeal radiation injury induced by radiotherapy in patients with nasopharyngeal carcinoma (NPC).
  
  
  METHODS
  A total of 255 NPC patients with rhinosinusal and laryngeal radiation injury following radiotherapy were randomized into 3 groups for treatment with clarithromycin (group A, n=69), tanshinone (group B, n=69), and clarithromycin + tanshinone (group C, n=69), and the clinical outcomes of the patients were evaluated.
  
  
  RESULTS
  In all the 3 groups the patients responded favorably to the treatments and showed obvious improvements (P<0.05). The therapeutic effects were similar between groups A and B (P>0.05), but the patients in group C showed the most obvious improvements (P<0.05).
  
  
  CONCLUSIONS
  Clarithromycin combined with tanshinone can be an effective regimen for treatment of rhinosinusal and laryngeal radiation injury induced by radiotherapy in NPC patients.
authors.affiliation: Department of Otolaryngology, First Affiliated Hospital of Jinan University, Guangzhou, China. dl-lh1995@163.com
authors.forename: Hui
authors.initials: H
authors.lastname: Li
authors.forename: Huadong
authors.initials: H
authors.lastname: Wang
authors.forename: Yukun
authors.initials: Y
authors.lastname: Ma
authors.forename: Jianfu
authors.initials: J
authors.lastname: Zhao
mesh_terms: D045784:Abietanes / Q000627:therapeutic use*; D000328:Adult; D000368:Aged; D002277:Carcinoma; D017291:Clarithromycin / Q000627:therapeutic use*; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D007830:Larynx / Q000473:pathology; D008297:Male; D008875:Middle Aged; D000077274:Nasopharyngeal Carcinoma; D009303:Nasopharyngeal Neoplasms / Q000532:radiotherapy; D009666:Nose / Q000473:pathology; D010256:Paranasal Sinuses / Q000473:pathology; D010614:Pharynx / Q000473:pathology; D011832:Radiation Injuries / Q000188:drug therapy*; D055815:Young Adult
chemical_list: D045784:Abietanes; C021751:tanshinone; D017291:Clarithromycin