title: Review of the neurological manifestations of hepatitis E infection.
abstract: Hepatitis E (HEV) is a common infection worldwide and is an emerging disease in developed countries. The presence of extra-hepatic manifestation of HEV infection is important to bear in mind so that the diagnosis is not missed, since HEV is not routinely tested for in acute hepatitis due to perceived rarity of this infection outside of endemic countries. This article reviews the neurological presentations of acute and chronic HEV, and discusses the viral kinetics against symptomatology, and outcomes of specific treatment. Possible mechanisms of pathogenesis are considered.
authors.affiliation: Institute  of  Liver  Studies,  King's  College  Hospital,  Denmark  Hill,  London,  United  Kingdom,  SE5  9RS.
authors.forename: Michelle C M
authors.initials: MC
authors.lastname: Cheung
authors.forename: James
authors.initials: J
authors.lastname: Maguire
authors.forename: Ivana
authors.initials: I
authors.lastname: Carey
authors.forename: Julia
authors.initials: J
authors.lastname: Wendon
authors.forename: Kosh
authors.initials: K
authors.lastname: Agarwal
mesh_terms: D000208:Acute Disease; D002908:Chronic Disease; D016751:Hepatitis E / Q000150:complications* / Q000175:diagnosis / Q000453:epidemiology; D016752:Hepatitis E virus / Q000472:pathogenicity*; D006801:Humans; D009420:Nervous System / Q000821:virology*; D009422:Nervous System Diseases / Q000175:diagnosis / Q000453:epidemiology / Q000821:virology*; D011379:Prognosis