title: Intake fraction for the indoor environment: a tool for prioritizing indoor chemical sources.
abstract: Reliable exposure-based chemical characterization tools are needed to evaluate and prioritize in a rapid and efficient manner the more than tens of thousands of chemicals in current use. This study applies intake fraction (iF), the integrated incremental intake of a chemical per unit of emission, for a suite of indoor released compounds. A fugacity-based indoor mass-balance model was used to simulate the fate and transport of chemicals for three release scenarios: direct emissions to room air and surface applications to carpet and vinyl. Exposure through inhalation, dermal uptake, and nondietary ingestion was estimated. To compute iF, cumulative intake was summed from all exposure pathways for 20 years based on a scenario with two adults and a 1-year-old child who ages through the simulation. Overall iFs vary by application modes: air release (3.1 × 10(-3) to 6.3 × 10(-3)), carpet application (3.8 × 10(-5) to 6.2 × 10(-3)), and vinyl application (9.0 × 10(-5) to 1.8 × 10(-2)). These iF values serve as initial estimates that offer important insights on variations among chemicals and the potential relative contribution of each pathway over a suite of compounds. The approach from this study is intended for exposure-based prioritization of chemicals released inside homes.
authors.affiliation: Department of Public Health Sciences, University of California-Davis, Davis, California, United States. hmshin@ucdavis.edu
authors.forename: Hyeong-Moo
authors.initials: HM
authors.lastname: Shin
authors.forename: Thomas E
authors.initials: TE
authors.lastname: McKone
authors.forename: Deborah H
authors.initials: DH
authors.lastname: Bennett
mesh_terms: D000328:Adult; D000393:Air Pollutants / Q000032:analysis* / Q000378:metabolism*; D016902:Air Pollution, Indoor / Q000032:analysis*; D004784:Environmental Monitoring; D005430:Floors and Floorcoverings; D006801:Humans; D007223:Infant; D019570:Inhalation Exposure / Q000032:analysis*; D008954:Models, Biological; D008956:Models, Chemical; D012869:Skin Absorption
chemical_list: D000393:Air Pollutants