title: Regio- and stereoselective oxidative phenol coupling in Aspergillus niger.
abstract: Piecing it together: Aspergillus niger produces kotanin by dimerization of the monomeric, polyketide-synthase-derived (PKS) 7-demethylsiderin. A combined approach, comprising bioinformatics and gene-deletion experiments, identified the biosynthetic cluster responsible for kotanin production. Homology modeling and substrate docking provide a rationale for the regio- and stereoselective phenol coupling reaction.
authors.affiliation: Institut für Pharmazeutische Wissenschaften, Albert-Ludwigs-Universität Freiburg, Freiburg, Germany.
authors.forename: Christian
authors.initials: C
authors.lastname: Gil Girol
authors.forename: Katja M
authors.initials: KM
authors.lastname: Fisch
authors.forename: Thorsten
authors.initials: T
authors.lastname: Heinekamp
authors.forename: Stefan
authors.initials: S
authors.lastname: Günther
authors.forename: Wolfgang
authors.initials: W
authors.lastname: Hüttel
authors.forename: Jörn
authors.initials: J
authors.lastname: Piel
authors.forename: Axel A
authors.initials: AA
authors.lastname: Brakhage
authors.forename: Michael
authors.initials: M
authors.lastname: Müller
mesh_terms: D001234:Aspergillus niger / Q000737:chemistry / Q000201:enzymology / Q000378:metabolism*; D003374:Coumarins / Q000737:chemistry / Q000378:metabolism*; D008958:Models, Molecular; D058451:Oxidative Coupling; D010636:Phenols / Q000737:chemistry / Q000378:metabolism*; D061065:Polyketides / Q000737:chemistry / Q000378:metabolism*; D013237:Stereoisomerism
chemical_list: D003374:Coumarins; D010636:Phenols; D061065:Polyketides; C521327:kotanin