title: Chiral separation of amino acids derivatised with fluorescein isothiocyanate by single isomer derivatives 3-monodeoxy-3-monoamino-β- and γ-cyclodextrins: the effect of the cavity size.
abstract: Thirteen enantiomeric pairs of α-amino acids derivatised with fluorescein isothiocyanate (FITC-AAs) were separated in capillary electrophoresis (CE) using as chiral selectors the single isomer derivatives (SIDs) 3-monodeoxy-3-monoamino-β- and γ-cyclodextrins. The chiral separation data obtained by these strictly homologous compounds, show different behaviours, allowing to hypothesise a possible structure of the obtained selector-analyte complexes, as well as highlighting the crucial role of the cavity size and the significant effects on the resolution obtained by small differences in the structural characteristics of these analytes.
authors.affiliation: University of Catania, Department of Chemical Sciences, Viale A. Doria 6, 95125 Catania, Italy. agiuffri@unict.it
authors.forename: Alessandro
authors.initials: A
authors.lastname: Giuffrida
authors.forename: Rosario
authors.initials: R
authors.lastname: Caruso
authors.forename: Marianna
authors.initials: M
authors.lastname: Messina
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Maccarrone
authors.forename: Annalinda
authors.initials: A
authors.lastname: Contino
authors.forename: Alejandro
authors.initials: A
authors.lastname: Cifuentes
authors.forename: Vincenzo
authors.initials: V
authors.lastname: Cucinotta
mesh_terms: D003505:Cyclodextrins / Q000737:chemistry*; D019075:Electrophoresis, Capillary / Q000379:methods*; D016650:Fluorescein-5-isothiocyanate / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D003505:Cyclodextrins; D016650:Fluorescein-5-isothiocyanate