title: Growth inhibition of Walker carcinosarcoma 256 with alcoholic extract of green tea leaves (Camellia sinensis).
abstract: OBJECTIVE
  To evaluate the antitumor activity of alcoholic extracts of green tea (Camella sinensis).
  
  
  METHODS
  Four groups of six Wistar rats were inoculated intramuscularly with 10(6) Walker tumor cells/mL. During 10 days, the animals received by gavage either 0.9% saline solution (Group I; negative control), solution containing 20 mg/Kg of tamoxifen (Group II; positive control), solution containing 0.07 g/Kg alcoholic extract of C. sinensis (Group III), or solution containing 0.14 g/Kg alcoholic extract of C. sinensis (Group IV). Following euthanasia on the tenth day, the tumor, liver, kidneys and spleen were excised and weighed, and tumor volume and tumor growth inhibition were quantified.
  
  
  RESULTS
  The average weight of the animals was greater in Group IV than in Group II (p=0.0107). Tumor weight was smaller in Group IV than in Group I (p=0.0062), but did not differ from Group II. Tumor volume was smaller in Groups II and IV than in Group I (p=0.0131). Tumor growth inhibition was observed in Groups II (44.67% ± 32.47), III (16.83% ± 53.02) and IV (66.4% ± 25.82) (p>0.05). The groups did not differ with regard to the weight of the excised organs.
  
  
  CONCLUSIONS
  Alcoholic extracts of green tea have antitumor activity.
authors.affiliation: School of Pharmacy, UNIFOR, Fortaleza-CE, Brazil.
authors.forename: Mauriclécio Franco
authors.initials: MF
authors.lastname: Ponte
authors.forename: Thiago Sousa e Silva
authors.initials: TS
authors.lastname: Targino
authors.forename: Matheus Alves de Lima
authors.initials: MA
authors.lastname: Mota
authors.forename: José Saul Peixoto
authors.initials: JS
authors.lastname: Landim
authors.forename: Thyciana Rodrigues
authors.initials: TR
authors.lastname: Ribeiro
authors.forename: Fabiana Pereira
authors.initials: FP
authors.lastname: Soares
authors.forename: Márcio Roberto Pinho
authors.initials: MR
authors.lastname: Pereira
authors.forename: Sônia Leite da
authors.initials: SL
authors.lastname: Silva
authors.forename: Silvia Fernandes Ribeiro da
authors.initials: SF
authors.lastname: Silva
mesh_terms: D000818:Animals; D028241:Camellia sinensis / Q000737:chemistry*; D002279:Carcinoma 256, Walker / Q000139:chemically induced / Q000188:drug therapy*; D002392:Catechin / Q000494:pharmacology*; D007680:Kidney Neoplasms / Q000139:chemically induced / Q000188:drug therapy*; D008113:Liver Neoplasms / Q000139:chemically induced / Q000188:drug therapy*; D008297:Male; D008517:Phytotherapy; D010936:Plant Extracts / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D013160:Splenic Neoplasms / Q000139:chemically induced / Q000188:drug therapy*; D013662:Tea / Q000737:chemistry
chemical_list: D010936:Plant Extracts; D013662:Tea; D002392:Catechin