title: [Diabetes mellitus and osteoporosis. Incretin as a coordinator of glucose and bone metabolism].
abstract: GLP-1 and GIP play an important role as incretin to stimulate insulin secretion from pancreatic β-cells and to maintain the homeostasis of glucose metabolism. As GLP-1 receptors are expressed in thyroid C cells and GIP receptors are expressed in osteoblasts, incretin contributes to bone metabolism. GIP maintains the homeostasis of bone metabolism through transiently activating osteoblasts.
authors.affiliation: Department of Endocrinology, Diabetes and Geriatric Medicine, Akita University Graduate School of Medicine, Japan.
authors.forename: Yuichiro
authors.initials: Y
authors.lastname: Yamada
mesh_terms: D000818:Animals; D001842:Bone and Bones / Q000378:metabolism* / Q000473:pathology; D048909:Diabetes Complications / Q000378:metabolism*; D052216:Glucagon-Like Peptide 1 / Q000378:metabolism; D005947:Glucose / Q000378:metabolism*; D006801:Humans; D054795:Incretins / Q000378:metabolism*; D010024:Osteoporosis / Q000378:metabolism*
chemical_list: D054795:Incretins; D052216:Glucagon-Like Peptide 1; D005947:Glucose