title: Case of polycythemia vera concurrent with FIP1L1-PDGFRA-positive myeloproliferative neoplasm with eosinophilia.
abstract: We report an unusual case of a symptomatic patient who initially had high hemoglobin and low serum erythropoietin levels, fitting a clinical diagnosis of polycythemia vera. However, after treatment with hydroxyurea and serial phlebotomies had been started, the patient developed hypereosinophilia, fitting the category of a myeloproliferative neoplasm with eosinophilia associated with the FIP1L1-PDGFRA gene fusion, as confirmed by molecular analysis. We discuss the clinical presentation, evolution, response to treatment, and pathogenetic implications of this case.
authors.affiliation: Department of Melanoma Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA. anrawas@yahoo.com
authors.forename: Anas
authors.initials: A
authors.lastname: Alrwas
authors.forename: Jorge R
authors.initials: JR
authors.lastname: Quesada
authors.forename: Luis A
authors.initials: LA
authors.lastname: Marcos
authors.forename: Shivang S
authors.initials: SS
authors.lastname: Mehta
authors.forename: Brandy L
authors.initials: BL
authors.lastname: Shattuck
authors.forename: Nghia D
authors.initials: ND
authors.lastname: Nguyen
authors.forename: Harinder S
authors.initials: HS
authors.lastname: Juneja
mesh_terms: D000970:Antineoplastic Agents / Q000627:therapeutic use; D001549:Benzamides; D001706:Biopsy; D004802:Eosinophilia / Q000150:complications / Q000175:diagnosis* / Q000235:genetics*; D020022:Genetic Predisposition to Disease; D006801:Humans; D000068877:Imatinib Mesylate; D008297:Male; D008875:Middle Aged; D008957:Models, Genetic; D009154:Mutation; D009196:Myeloproliferative Disorders / Q000150:complications / Q000175:diagnosis / Q000235:genetics*; D010879:Piperazines / Q000627:therapeutic use; D011087:Polycythemia Vera / Q000150:complications / Q000175:diagnosis* / Q000235:genetics*; D011743:Pyrimidines / Q000627:therapeutic use; D020796:Receptor, Platelet-Derived Growth Factor alpha / Q000235:genetics*; D012074:Remission Induction; D039221:mRNA Cleavage and Polyadenylation Factors / Q000235:genetics*
chemical_list: D000970:Antineoplastic Agents; D001549:Benzamides; C479818:FIP1L1 protein, human; D010879:Piperazines; D011743:Pyrimidines; D039221:mRNA Cleavage and Polyadenylation Factors; D000068877:Imatinib Mesylate; D020796:Receptor, Platelet-Derived Growth Factor alpha