title: Improved survival with iron chelation therapy for red blood cell transfusion dependent lower IPSS risk MDS may be more significant in patients with a non-RARS diagnosis.
abstract: Retrospective analyses suggest iron overload is associated with inferior survival (OS) in lower risk MDS and iron chelation therapy (ICT) with improvement. However, an analysis of RARS patients found no such association. We analyzed subtypes of lower risk MDS. Median OS for non-RARS without and with ICT was 44 months and not reached (P<0.001), and for RARS 99 and 134.4 months (P=NS); in red blood cell (RBC) transfusion dependent RARS patients not receiving ICT, median OS was 73.8 months (P=0.025). These results suggest a stronger association between ICT and OS in non-RARS MDS than in RARS, with significantly superior OS in transfusion dependent patients receiving ICT.
authors.affiliation: Hematology, St. Paul's Hospital, University of British Columbia, Vancouver, BC, Canada. hleitch@providencehematology.com
authors.forename: Heather A
authors.initials: HA
authors.lastname: Leitch
authors.forename: Christopher
authors.initials: C
authors.lastname: Chan
authors.forename: Chantal S
authors.initials: CS
authors.lastname: Leger
authors.forename: Lynda M
authors.initials: LM
authors.lastname: Foltz
authors.forename: Khaled M
authors.initials: KM
authors.lastname: Ramadan
authors.forename: Linda M
authors.initials: LM
authors.lastname: Vickars
mesh_terms: D000368:Aged; D015913:Chelation Therapy; D017707:Erythrocyte Transfusion; D005260:Female; D006801:Humans; D007502:Iron Chelating Agents / Q000627:therapeutic use; D053208:Kaplan-Meier Estimate; D008297:Male; D009190:Myelodysplastic Syndromes / Q000401:mortality* / Q000628:therapy*; D011379:Prognosis; D016016:Proportional Hazards Models; D012189:Retrospective Studies; D016896:Treatment Outcome
chemical_list: D007502:Iron Chelating Agents