title: Orthostatic intolerance in multifocal acquired demyelinating sensory and motor neuropathy.
abstract: We report a patient with orthostatic intolerance and syncope as a major clinical manifestation of an acquired multifocal neuropathy with the clinical, electrodiagnostic, and cerebrospinal fluid features of multifocal acquired demyelinating sensory and motor neuropathy or the Lewis-Sumner syndrome. Immunomodulatory therapy led to clinical remission of both somatic and autonomic signs and symptoms. We are unaware of a previous description of symptomatic dysautonomia in this disorder.
authors.affiliation: Department of Neurology, Tufts Neurology Residency Program, Tufts Medical Center, Lahey Clinic Medical Center, St. Elizabeth's Medical Center, Boston, MA 02111, USA. louis.tramontozzi@gmail.com
authors.forename: Louis A
authors.initials: LA
authors.lastname: Tramontozzi
authors.forename: James A
authors.initials: JA
authors.lastname: Russell
mesh_terms: D000328:Adult; D003711:Demyelinating Diseases / Q000150:complications*; D004568:Electrodiagnosis / Q000379:methods; D006801:Humans; D008297:Male; D009431:Neural Conduction / Q000502:physiology; D054971:Orthostatic Intolerance / Q000175:diagnosis / Q000209:etiology*; D010525:Peripheral Nerves / Q000503:physiopathology; D011115:Polyneuropathies / Q000150:complications*