title: A case-control study of the risk of adverse perinatal outcomes due to tuberculosis during pregnancy.
abstract: We conducted a case-control study at three main inner-city hospitals in Birmingham, UK between 2004 and 2006, to determine the risk of adverse perinatal outcomes in pregnant women with tuberculosis (TB) (n = 24), compared with healthy pregnant controls (n = 72). The incidence of TB was 62/100,000 pregnancies, with 54.2% cases having pulmonary TB (41.7% extra-pulmonary; 4.2% both). Infants of mothers with TB had a significantly lower mean birth weight compared with controls (2,735 g vs 3,135 g; p = 0.03). Mean birth weight was lower in pulmonary TB than in the extra-pulmonary TB. Multivariate analysis showed that low birth weight was associated with pre-term delivery (p < 0.001). We conclude that pregnant women with TB are at higher risk of low birth weight due to higher odds of pre-term delivery.
authors.affiliation: Department of Respiratory Medicine, Queen Elizabeth Hospital, London.
authors.forename: B
authors.initials: B
authors.lastname: Asuquo
authors.forename: A D
authors.initials: AD
authors.lastname: Vellore
authors.forename: G
authors.initials: G
authors.lastname: Walters
authors.forename: S
authors.initials: S
authors.lastname: Manney
authors.forename: L
authors.initials: L
authors.lastname: Mignini
authors.forename: H
authors.initials: H
authors.lastname: Kunst
mesh_terms: D000328:Adult; D001724:Birth Weight; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D007230:Infant, Low Birth Weight; D007231:Infant, Newborn; D015999:Multivariate Analysis; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious; D011256:Pregnancy Outcome; D047928:Premature Birth / Q000453:epidemiology; D012307:Risk Factors; D014376:Tuberculosis / Q000150:complications* / Q000453:epidemiology; D014397:Tuberculosis, Pulmonary / Q000150:complications / Q000453:epidemiology; D006113:United Kingdom / Q000453:epidemiology