title: Inhibitors of reactive oxygen species accumulation delay and/or reduce the lethality of several antistaphylococcal agents.
abstract: Perturbation of hydroxyl radical accumulation by subinhibitory concentrations of 2,2'-bipyridyl plus thiourea protects Escherichia coli from being killed by 3 lethal antimicrobial classes. Here, we show that 2,2'-bipyridyl plus thiourea delays and/or reduces antimicrobial killing of Staphylococcus aureus by daptomycin, moxifloxacin, and oxacillin. While the protective effect of 2,2'-bipyridyl plus thiourea varied among strains and compounds, the data support the hypothesis that hydroxyl radical enhances antimicrobial lethality.
authors.affiliation: Department of Biochemistry, Harbin Medical University, Harbin, Heilongjiang Province, China.
authors.forename: Yuanli
authors.initials: Y
authors.lastname: Liu
authors.forename: Xinghan
authors.initials: X
authors.lastname: Liu
authors.forename: Yilin
authors.initials: Y
authors.lastname: Qu
authors.forename: Xiuhong
authors.initials: X
authors.lastname: Wang
authors.forename: Liping
authors.initials: L
authors.lastname: Li
authors.forename: Xilin
authors.initials: X
authors.lastname: Zhao
mesh_terms: D015082:2,2'-Dipyridyl / Q000494:pharmacology; D000900:Anti-Bacterial Agents / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D001372:Aza Compounds / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D017576:Daptomycin / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D024841:Fluoroquinolones; D008826:Microbial Sensitivity Tests; D000077266:Moxifloxacin; D010068:Oxacillin / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D011804:Quinolines / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D017382:Reactive Oxygen Species / Q000037:antagonists & inhibitors / Q000378:metabolism*; D013211:Staphylococcus aureus / Q000187:drug effects* / Q000254:growth & development; D013890:Thiourea / Q000494:pharmacology; D013997:Time Factors
chemical_list: D000900:Anti-Bacterial Agents; D001372:Aza Compounds; D024841:Fluoroquinolones; D011804:Quinolines; D017382:Reactive Oxygen Species; D015082:2,2'-Dipyridyl; D013890:Thiourea; D017576:Daptomycin; D000077266:Moxifloxacin; D010068:Oxacillin