title: How can measurement, monitoring, modeling and control advance cell culture in industrial biotechnology?
abstract: This report highlights the potential of measurement, monitoring, modeling and control (M(3) C) methodologies in animal and human cell culture technology. In particular, state-of-the-art of M(3) C technologies and their industrial relevance of existing technology are addressed. It is a summary of an expert panel discussion between biotechnologists and biochemical engineers with both academic and industrial backgrounds. The latest ascents in M(3) C are discussed from a cell culture perspective for industrial process development and production needs. The report concludes with a set of recommendations for targeting M(3) C research toward the industrial interests. These include issues of importance for biotherapeutics production, miniaturization of measurement techniques and modeling methods.
authors.affiliation: Instituto de Biologia Experimental e Tecnológica (IBET), Oeiras, Portugal.
authors.forename: Manuel J T
authors.initials: MJ
authors.lastname: Carrondo
authors.forename: Paula M
authors.initials: PM
authors.lastname: Alves
authors.forename: Nuno
authors.initials: N
authors.lastname: Carinhas
authors.forename: Jarka
authors.initials: J
authors.lastname: Glassey
authors.forename: Friedemann
authors.initials: F
authors.lastname: Hesse
authors.forename: Otto-Wilhelm
authors.initials: OW
authors.lastname: Merten
authors.forename: Martina
authors.initials: M
authors.lastname: Micheletti
authors.forename: Thomas
authors.initials: T
authors.lastname: Noll
authors.forename: Rui
authors.initials: R
authors.lastname: Oliveira
authors.forename: Udo
authors.initials: U
authors.lastname: Reichl
authors.forename: Arne
authors.initials: A
authors.lastname: Staby
authors.forename: Ana P
authors.initials: AP
authors.lastname: Teixeira
authors.forename: Henry
authors.initials: H
authors.lastname: Weichert
authors.forename: Carl-Fredrik
authors.initials: CF
authors.lastname: Mandenius
mesh_terms: D000818:Animals; D019149:Bioreactors; D001709:Biotechnology / Q000379:methods* / Q000592:standards; D018929:Cell Culture Techniques / Q000592:standards; D004345:Drug Industry / Q000379:methods* / Q000592:standards; D005822:Genetic Vectors / Q000737:chemistry; D006801:Humans; D011506:Proteins / Q000737:chemistry / Q000378:metabolism; D013234:Stem Cells / Q000166:cytology
chemical_list: D011506:Proteins