title: Maternal autism-associated IgG antibodies delay development and produce anxiety in a mouse gestational transfer model.
abstract: A murine passive transfer model system was employed to ascertain the effects of gestational exposure to a single, intravenous dose of purified, brain-reactive IgG antibodies from individual mothers of children with autism (MAU) or mothers with typically developing children (MTD). Growth and behavioral outcomes in offspring were measured from postnatal days 8 to 65 in each group. Comparisons revealed alterations in early growth trajectories, significantly impaired motor and sensory development, and increased anxiety. This report demonstrates for the first time the effects of a single, low dose gestational exposure of IgG derived from individual MAU on their offspring's physical and social development.
authors.affiliation: Division of Rheumatology/Allergy and Clinical Immunology, University of California, Davis, 451 E. Health Sciences Drive, Suite 6510 GBSF, Davis, CA 95616, USA. dnau@ucdavis.edu
authors.forename: Daniel
authors.initials: D
authors.lastname: Braunschweig
authors.forename: Mari S
authors.initials: MS
authors.lastname: Golub
authors.forename: Claire M
authors.initials: CM
authors.lastname: Koenig
authors.forename: Lihong
authors.initials: L
authors.lastname: Qi
authors.forename: Isaac N
authors.initials: IN
authors.lastname: Pessah
authors.forename: Judy
authors.initials: J
authors.lastname: Van de Water
authors.forename: Robert F
authors.initials: RF
authors.lastname: Berman
mesh_terms: D000818:Animals; D001007:Anxiety / Q000276:immunology; D001321:Autistic Disorder / Q000276:immunology*; D001323:Autoantibodies / Q000008:administration & dosage* / Q000276:immunology; D001324:Autoantigens / Q000276:immunology; D001522:Behavior, Animal / Q000187:drug effects; D001921:Brain / Q000276:immunology; D004195:Disease Models, Animal; D005260:Female; D048788:Growth and Development / Q000187:drug effects*; D006801:Humans; D007074:Immunoglobulin G / Q000008:administration & dosage* / Q000276:immunology; D051379:Mice; D008810:Mice, Inbred C57BL; D009035:Mothers; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects / Q000276:immunology*
chemical_list: D001323:Autoantibodies; D001324:Autoantigens; D007074:Immunoglobulin G