title: Synthesis of the tetracyclic core (ABCE rings) of daphenylline.
abstract: A concise synthesis of the tetracyclic core (ABCE rings) of daphenylline has been accomplished involving a benzobicyclo[3.3.1] lactam as the key intermediate. This bridged bicyclic intermediate was efficiently constructed via a Brønsted acid promoted intramolecular Friedel-Crafts type Michael addition of a δ-benzyl α,β-unsaturated δ-lactam.
authors.affiliation: State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou, Gansu, 730000, PR China.
authors.forename: Bowen
authors.initials: B
authors.lastname: Fang
authors.forename: Huaiji
authors.initials: H
authors.lastname: Zheng
authors.forename: Changgui
authors.initials: C
authors.lastname: Zhao
authors.forename: Peng
authors.initials: P
authors.lastname: Jing
authors.forename: Huilin
authors.initials: H
authors.lastname: Li
authors.forename: Xingang
authors.initials: X
authors.lastname: Xie
authors.forename: Xuegong
authors.initials: X
authors.lastname: She
mesh_terms: D000470:Alkaloids / Q000138:chemical synthesis* / Q000737:chemistry*; D001952:Bridged-Ring Compounds / Q000737:chemistry*; D003500:Cyclization; D007769:Lactams / Q000737:chemistry*; D011083:Polycyclic Compounds / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D000470:Alkaloids; D001952:Bridged-Ring Compounds; D007769:Lactams; D011083:Polycyclic Compounds; C541594:daphenylline