title: TAK1, more than just innate immunity.
abstract: Transforming growth factor β-activated kinase 1 (TAK1) is a key regulator of the innate immunity and the proinflammatory signaling pathway. In response to interleukin-1, tumor necrosis factor-α, and toll-like receptor agonists, it mediates the activation of the nuclear factor κB (NF-κB), c-Jun N-terminal kinase (JNK), and p38 pathways. In addition, TAK1 plays a central role in adaptive immunity, in which it mediates signaling from T- and B-cell receptors. This review will focus on recent developments and also examine the regulation of TAK1 in response to a diverse range of other stimuli including DNA damage, transforming growth factor-β, Wnt, osmotic stress, and hypoxia.
authors.affiliation: Division of Molecular and Cell Biology, School of Biological Sciences, Nanyang Technological University, Singapore.
authors.forename: Liang
authors.initials: L
authors.lastname: Dai
authors.forename: Chan
authors.initials: C
authors.lastname: Aye Thu
authors.forename: Xin-Yu
authors.initials: XY
authors.lastname: Liu
authors.forename: Jiajia
authors.initials: J
authors.lastname: Xi
authors.forename: Peter C F
authors.initials: PC
authors.lastname: Cheung
mesh_terms: D056704:Adaptive Immunity; D000818:Animals; D016207:Cytokines / Q000276:immunology / Q000378:metabolism; D004249:DNA Damage / Q000276:immunology; D005786:Gene Expression Regulation / Q000276:immunology*; D006801:Humans; D000860:Hypoxia / Q000276:immunology; D007113:Immunity, Innate; D048670:MAP Kinase Kinase 4 / Q000235:genetics / Q000276:immunology; D020930:MAP Kinase Kinase Kinases / Q000235:genetics / Q000276:immunology*; D051379:Mice; D016328:NF-kappa B / Q000235:genetics / Q000276:immunology; D015398:Signal Transduction / Q000276:immunology*; D051193:Toll-Like Receptors / Q000235:genetics / Q000276:immunology; D048051:p38 Mitogen-Activated Protein Kinases / Q000235:genetics / Q000276:immunology; D000099151:MAP Kinase Kinase Kinase 7
chemical_list: D016207:Cytokines; D048670:MAP Kinase Kinase 4; D020930:MAP Kinase Kinase Kinases; D016328:NF-kappa B; D051193:Toll-Like Receptors; D048051:p38 Mitogen-Activated Protein Kinases; D000099151:MAP Kinase Kinase Kinase 7