title: A combinatorial approach toward smart libraries of discontinuous epitopes of HIV gp120 on a TAC synthetic scaffold.
abstract: We describe rapid and convenient access to smart libraries of protein surface discontinuous epitope mimics. Up to three different cyclic peptides, representing discontinuous epitopes in HIV-gp120, were conjugated to a triazacyclophane scaffold molecule via CuAAC. In this way protein mimics for use as synthetic vaccines and beyond will become available.
authors.affiliation: Medicinal Chemistry & Chemical Biology, Utrecht Institute of Pharmaceutical Sciences, Faculty of Science, Utrecht University, P.O. Box 80082, NL-3508 TB Utrecht, The Netherlands.
authors.forename: Gwenn E
authors.initials: GE
authors.lastname: Mulder
authors.forename: John A W
authors.initials: JA
authors.lastname: Kruijtzer
authors.forename: Rob M J
authors.initials: RM
authors.lastname: Liskamp
mesh_terms: D000595:Amino Acid Sequence; D000939:Epitopes / Q000737:chemistry*; D006678:HIV / Q000737:chemistry*; D015699:HIV Envelope Protein gp120 / Q000737:chemistry*; D008958:Models, Molecular; D010456:Peptides, Cyclic / Q000138:chemical synthesis* / Q000737:chemistry; D054852:Small Molecule Libraries / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D000939:Epitopes; D015699:HIV Envelope Protein gp120; D010456:Peptides, Cyclic; D054852:Small Molecule Libraries