title: Unraveling stress-induced toxicity properties of graphene oxide and the underlying mechanism.
abstract: Graphene oxide shows stress-induced toxicity properties in vivo under different pathophysiological conditions. A dual-path chemical mechanism, involving the overproduction of hydroxyl radicals and the formation of oxidizing cytochrome c intermediates, is responsible for the toxicity properties.
authors.affiliation: CAS Key Laboratory for Biomedical Effects of Nanomaterials & Nanosafety, National Center for Nanoscience and Technology, Beijing 100190, China.
authors.forename: Wendi
authors.initials: W
authors.lastname: Zhang
authors.forename: Chi
authors.initials: C
authors.lastname: Wang
authors.forename: Zhongjun
authors.initials: Z
authors.lastname: Li
authors.forename: Zhenzhen
authors.initials: Z
authors.lastname: Lu
authors.forename: Yiye
authors.initials: Y
authors.lastname: Li
authors.forename: Jun-Jie
authors.initials: JJ
authors.lastname: Yin
authors.forename: Yu-Ting
authors.initials: YT
authors.lastname: Zhou
authors.forename: Xingfa
authors.initials: X
authors.lastname: Gao
authors.forename: Ying
authors.initials: Y
authors.lastname: Fang
authors.forename: Guangjun
authors.initials: G
authors.lastname: Nie
authors.forename: Yuliang
authors.initials: Y
authors.lastname: Zhao
mesh_terms: D000818:Animals; D017173:Caenorhabditis elegans / Q000187:drug effects* / Q000378:metabolism; D003497:Cyclic N-Oxides / Q000737:chemistry; D006108:Graphite / Q000737:chemistry* / Q000633:toxicity*; D049329:Nanostructures / Q000633:toxicity*; D018384:Oxidative Stress; D010087:Oxides / Q000737:chemistry* / Q000633:toxicity; D011092:Polyethylene Glycols / Q000737:chemistry; D011107:Polylysine / Q000737:chemistry
chemical_list: C025634:5,5-dimethylpyrrolidin-2-one-1-oxide; D003497:Cyclic N-Oxides; D010087:Oxides; D011107:Polylysine; D011092:Polyethylene Glycols; D006108:Graphite