title: Epitopic hexapeptide sequences from Baltic cod parvalbumin beta (allergen Gad c 1) are common in the universal proteome.
abstract: The aim of this study was to analyze the distribution of hexapeptide fragments considered as epitopes of Baltic cod parvalbumin beta (allergen Gad c 1) in the universal proteome. Cod (Gadus morhua subsp. callarias) parvalbumin hexapeptides cataloged in the Immune Epitope Database were used as query sequences. The UniProt database was screened using the WU-BLAST 2 program. The distribution of hexapeptide fragments was investigated in various protein families, classified according to the presence of the appropriate domains, and in proteins of plant, animal and microbial species. Hexapeptides from cod parvalbumin were found in the proteins of plants and animals which are food sources, microorganisms with various applications in food technology and biotechnology, microorganisms which are human symbionts and commensals as well as human pathogens. In the last case possible coverage between epitopes from pathogens and allergens should be avoided during vaccine design.
authors.affiliation: University of Warmia and Mazury in Olsztyn, Chair of Food Biochemistry, Olsztyn-Kortowo, Poland. minkiew@uwm.edu.pl
authors.forename: Piotr
authors.initials: P
authors.lastname: Minkiewicz
authors.forename: Justyna
authors.initials: J
authors.lastname: Bucholska
authors.forename: Małgorzata
authors.initials: M
authors.lastname: Darewicz
authors.forename: Justyna
authors.initials: J
authors.lastname: Borawska
mesh_terms: D000485:Allergens / Q000737:chemistry / Q000276:immunology; D000818:Animals; D030562:Databases, Protein; D000939:Epitopes / Q000737:chemistry / Q000276:immunology*; D048389:Gadus morhua / Q000276:immunology*; D010320:Parvalbumins / Q000737:chemistry / Q000276:immunology*; D020543:Proteome / Q000276:immunology*
chemical_list: D000485:Allergens; D000939:Epitopes; D010320:Parvalbumins; D020543:Proteome