title: An efficient total synthesis of a potent anti-inflammatory agent, benzocamphorin F, and its anti-inflammatory activity.
abstract: A naturally occurring enynyl-benzenoid, benzocamphorin F (1), from the edible fungus Taiwanofungus camphoratus (Antrodia camphorata) was characterized by comprehensive spectral analysis. It displays anti-inflammatory bioactivity and is valuable for further biological studies. The present study is the first total synthesis of benzocamphorin F and the developed strategy described is a more efficient procedure that allowe the large-scale production of benzocamphorin F for further research of the biological activity both in vitro and in vivo.
authors.affiliation: Department of Chemistry, National Cheng Kung University, Tainan 701, Taiwan.
authors.forename: Yu-Ren
authors.initials: YR
authors.lastname: Liao
authors.affiliation: Department of Biotechnology, National Formosa University, Yunlin 632, Taiwan.
authors.forename: Ping-Chung
authors.initials: PC
authors.lastname: Kuo
authors.affiliation: Department of Chemistry, National Cheng Kung University, Tainan 701, Taiwan.
authors.forename: Jun-Weil
authors.initials: JW
authors.lastname: Liang
authors.affiliation: National Research Institute of Chinese Medicine, Taipei 112, Taiwan.
authors.forename: Yuh-Chiang
authors.initials: YC
authors.lastname: Shen
authors.affiliation: Department of Chemistry, National Cheng Kung University, Tainan 701, Taiwan.|Department of Pharmacy, China Medical University, Taichung 401, Taiwan.|Chinese Medicinal Research and Development Center, China Medical University Hospital, Taichung 401, Taiwan.
authors.forename: Tian-Shung
authors.initials: TS
authors.lastname: Wu
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D055491:Antrodia / Q000737:chemistry*; D001555:Benzene Derivatives / Q000138:chemical synthesis* / Q000494:pharmacology*; D002478:Cells, Cultured; D016166:Free Radical Scavengers / Q000138:chemical synthesis / Q000494:pharmacology; D051379:Mice; D017628:Microglia / Q000166:cytology / Q000187:drug effects*; D008958:Models, Molecular; D015394:Molecular Structure; D009569:Nitric Oxide / Q000378:metabolism*; D013329:Structure-Activity Relationship
chemical_list: D000893:Anti-Inflammatory Agents; D001555:Benzene Derivatives; D016166:Free Radical Scavengers; C000601075:benzocamphorin F; D009569:Nitric Oxide