title: Depiction of cavity formation in Terrien marginal degeneration by anterior segment optical coherence tomography.
abstract: OBJECTIVE
  To evaluate detailed morphologic changes of Terrien marginal degeneration (TMD) using anterior segment optical coherence tomography (AS-OCT).
  
  
  METHODS
  Two patients with TMD were examined by 1310-nm wavelength swept source optical coherence tomography, corneal topography, and slit-lamp microscopy.
  
  
  RESULTS
  AS-OCT depicted corneal thinning with intact epithelial layer in the peripheral cornea of both patients. Moreover, AS-OCT images of both patients clearly showed cavity formation surrounded and enclosed by intact epithelial and endothelial layers in the thinned area.
  
  
  CONCLUSIONS
  We demonstrate here the existence of cavity formation in the peripheral cornea with TMD. This observation suggests a possibility that corneal thinning in TMD is associated with cavity formation in the corneal stroma. AS-OCT is useful for the observation of detailed morphologic changes of diseased cornea.
authors.affiliation: Department of Ophthalmology, Tokyo Medical University, Tokyo, Japan. ninnin@ss.iij4u.or.jp
authors.forename: Takaaki
authors.initials: T
authors.lastname: Hattori
authors.forename: Shigeto
authors.initials: S
authors.lastname: Kumakura
authors.forename: Hideki
authors.initials: H
authors.lastname: Mori
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Goto
mesh_terms: D000328:Adult; D000368:Aged; D003315:Cornea / Q000473:pathology*; D003317:Corneal Dystrophies, Hereditary / Q000175:diagnosis*; D019781:Corneal Topography; D016039:Corneal Transplantation; D006801:Humans; D021621:Imaging, Three-Dimensional; D008297:Male; D041623:Tomography, Optical Coherence; D014792:Visual Acuity / Q000502:physiology