title: Chemistry and bioactivity of an artificial adenosylpeptide B(12) cofactor.
abstract: Artificial influence: We describe a semi-artificial adenosylpeptide B(12) that behaves as a cofactor in B(12)-dependent enzymatic reactions and demonstrate that the peptide backbone influences its chemical properties and modulates its bioactivity in vitro and in vivo. Inhibition of the growth of L. delbrueckii is demonstrated, thus providing a potentially powerful approach for the development of antibacterial and antiproliferative compounds.
authors.affiliation: Institute of Inorganic Chemistry, University of Zürich, Winterthurerstrasse 190, 8057 Zürich, Switzerland.
authors.forename: Kai
authors.initials: K
authors.lastname: Zhou
authors.forename: René M
authors.initials: RM
authors.lastname: Oetterli
authors.forename: Helmut
authors.initials: H
authors.lastname: Brandl
authors.forename: Fredrick E
authors.initials: FE
authors.lastname: Lyatuu
authors.forename: Wolfgang
authors.initials: W
authors.lastname: Buckel
authors.forename: Felix
authors.initials: F
authors.lastname: Zelder
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000494:pharmacology; D040761:Biomimetic Materials / Q000737:chemistry* / Q000378:metabolism; D003013:Clostridium / Q000187:drug effects / Q000201:enzymology; D003067:Coenzymes / Q000737:chemistry / Q000378:metabolism; D004791:Enzyme Inhibitors / Q000737:chemistry / Q000494:pharmacology; D006863:Hydrogen-Ion Concentration; D019751:Intramolecular Transferases / Q000037:antagonists & inhibitors / Q000378:metabolism; D007700:Kinetics; D048668:Lactobacillus delbrueckii / Q000187:drug effects; D010455:Peptides / Q000737:chemistry* / Q000378:metabolism; D013696:Temperature; D014805:Vitamin B 12 / Q000737:chemistry*
chemical_list: D000900:Anti-Bacterial Agents; D003067:Coenzymes; D004791:Enzyme Inhibitors; D010455:Peptides; D019751:Intramolecular Transferases; C021570:methylaspartate mutase; D014805:Vitamin B 12