title: [Subintimal angioplasty for chronic arterial occlusive disease: a systematic review].
abstract: OBJECTIVE
  To evaluate the clinical effectiveness of subintimal angioplasty in treating chronic arterial occlusive disease of lower extremity.
  
  
  METHODS
  Eligible studies concerning treatment by subintimal angioplasty in patients with arterial occlusive disease of lower extremity were identified from electronic database, cross-reference search and relative articles. The study quality and data extraction of all relevant articles were assessed by three independent reviewers. The study endpoints were technical success, primary patency, limb salvage, and complications.
  
  
  RESULTS
  A total of 352 studies were selected for comprehensive review. Fourteen studies including a total of 2350 patients matched the selection criteria. According to whether selective using of re-entry catheter were used or not, the technical success rates were 96.4% and 87% (P < 0.01). Limb salvage rate was 90.5% and 81.5% at 6 and 12 months respectively. Depending on whether preoperative use of anti-platelet drug, primary patency rate was 91% and 68.5% at 6 months respectively (P < 0.01). The complication rate was 8.25% without serious complications.
  
  
  CONCLUSIONS
  This Meta-analysis suggests that subintimal angioplasty is a safe and effective method in treating chronic arterial occlusive disease of lower extremity with high technical success rate and limb salvage, and low serious complications. Selective using of re-entry devices and preoperative anti-platelet drug can improve the technical success rate and primary patency rate significantly. Despite the high rate of technical and clinical success of the procedure, randomized contrast trials and long-term follow-up results are required to confirm the efficacy of these results.
authors.affiliation: Department of Vascular Surgery, Ninth People's Hospital, School of Medicine, Shanghai Jiaotong University, China.
authors.forename: Xiang-xiang
authors.initials: XX
authors.lastname: Li
authors.forename: Xin-wu
authors.initials: XW
authors.lastname: Lu
authors.forename: Kai-chuang
authors.initials: KC
authors.lastname: Ye
authors.forename: Mi-er
authors.initials: ME
authors.lastname: Jiang
mesh_terms: D017130:Angioplasty / Q000379:methods*; D001157:Arterial Occlusive Diseases / Q000601:surgery*; D006801:Humans; D035002:Lower Extremity / Q000098:blood supply; D016896:Treatment Outcome; D017539:Tunica Intima / Q000601:surgery*