title: Solid probe assisted nanoelectrospray ionization mass spectrometry for biological tissue diagnostics.
abstract: To perform remote and direct sampling for mass spectrometry, solid probe assisted nanoelectrospray ionization (SPA-nanoESI) has been newly developed. After capturing the sample on the tip of the needle by sticking it to the biological tissue, the needle was inserted into the solvent-preloaded nanoESI capillary from the backside. NanoESI gave abundant ion signals for human kidney tissues and the liver of a living mouse. The method is easy to operate and versatile because any biological specimen could be sampled away from the mass spectrometer. Minimal invasiveness is another merit of this method.
authors.affiliation: Clean Energy Research Center, University of Yamanashi, Takeda, Kofu, Japan. mandal@yamanashi.ac.jp
authors.forename: Mridul Kanti
authors.initials: MK
authors.lastname: Mandal
authors.forename: Kentaro
authors.initials: K
authors.lastname: Yoshimura
authors.forename: Subhrakanti
authors.initials: S
authors.lastname: Saha
authors.forename: Satoshi
authors.initials: S
authors.lastname: Ninomiya
authors.forename: Md Obaidur
authors.initials: MO
authors.lastname: Rahman
authors.forename: Zhan
authors.initials: Z
authors.lastname: Yu
authors.forename: Lee Chuin
authors.initials: LC
authors.lastname: Chen
authors.forename: Yasuo
authors.initials: Y
authors.lastname: Shida
authors.forename: Sen
authors.initials: S
authors.lastname: Takeda
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Nonami
authors.forename: Kenzo
authors.initials: K
authors.lastname: Hiraoka
mesh_terms: D000818:Animals; D006801:Humans; D007668:Kidney / Q000378:metabolism*; D007680:Kidney Neoplasms / Q000378:metabolism; D008099:Liver / Q000378:metabolism*; D008297:Male; D051379:Mice; D036103:Nanotechnology; D025341:Principal Component Analysis; D012997:Solvents / Q000737:chemistry; D021241:Spectrometry, Mass, Electrospray Ionization
chemical_list: D012997:Solvents