title: Novel diphenylmethyl-derived amide protecting group for efficient liquid-phase peptide synthesis: AJIPHASE.
abstract: An efficient method for the synthesis of peptides bearing an amide at the C-terminal is described. This method involves the attachment of a C-terminal protecting group bearing long aliphatic chains, followed by the repetition of simple reaction and precipitation steps with the combined advantages of liquid-phase peptide synthesis (LPPS) and solid-phase peptide synthesis (SPPS). Using this method, a hydrophobic peptide was successfully synthesized in good yield and high purity, which cannot be obtained satisfactorily by SPPS.
authors.affiliation: Research Institute for Bioscience Products and Fine Chemicals, AJINOMOTO Co., Inc., 1730 Hinaga Yokkaichi Mie 510-0885, Japan. daisuke_takahashi@ajinomoto.com
authors.forename: Daisuke
authors.initials: D
authors.lastname: Takahashi
authors.forename: Tatsuya
authors.initials: T
authors.lastname: Yano
authors.forename: Tatsuya
authors.initials: T
authors.lastname: Fukui
mesh_terms: D000577:Amides / Q000138:chemical synthesis* / Q000737:chemistry; D060326:Chemistry Techniques, Synthetic; D002851:Chromatography, High Pressure Liquid; D015394:Molecular Structure; D010455:Peptides / Q000138:chemical synthesis* / Q000737:chemistry; D060327:Solid-Phase Synthesis Techniques
chemical_list: D000577:Amides; D010455:Peptides