title: Serum leptin, resistin, visfatin and adiponectin levels in tumor necrosis factor receptor-associated periodic syndrome (TRAPS).
abstract: OBJECTIVE
  The aims of our study were to evaluate serum leptin, resistin, visfatin and adiponectin levels in patients with tumour necrosis factor receptor-associated periodic syndrome (TRAPS), in comparison to healthy controls, and to correlate their levels to parameters of disease activity and/or severity.
  
  
  METHODS
  Serum leptin, resistin, visfatin and adiponectin levels were obtained from 14 TRAPS patients carrying mutations involving cysteine residues, from 16 TRAPS patients carrying other mutations, and from 16 healthy controls. Demographic, clinical and laboratory parameters, including amyloidosis were entered for each patient. Comparisons between groups as well as reciprocal comparisons have been evaluated.
  
  
  RESULTS
  Serum leptin, resistin, visfatin and adiponectin did not significantly differ among the 3 groups. Patients carrying cysteine residues mutations showed lower visfatin serum levels than patients carrying other mutations (p<0.02). Serum leptin significantly correlated with the number of attacks/year (multiple R=0.32, multiple adjusted R2= 0.19, p <0.03). Serum adiponectin levels significantly correlated with the presence of amyloidosis (multiple R=0.79, multiple adjusted R2=0.57, p<0.03). Adiponectin values were a significant predictor for amyloidosis (AUC 0.75, 95 CI: 0.56-0.94, p<0.03), with a predicting cut-off value set at 23.16 pg/ml, the predictive positive value was 53.8%. Visfatin serum levels resulted respectively related to leptin (rs=0.42, r2=0.18, p<0.02) and to resistin (rs=0.57, r2=0.32, p<0.01) serum levels; whilst leptin and resistin serum levels did not reciprocally correlate.
  
  
  CONCLUSIONS
  Although a prospective design study and larger cohort are mandatory, adipokines serum levels and their correlations with parameters of disease activity and/or severity seem to show a baseline pattern in TRAPS patients.
authors.affiliation: Interdepartmental Research Center of Systemic Autoimmune and Autoinflammatory Diseases, Rheumatology Unit, Policlinico Le Scotte, University of Siena, 53100 Siena, Italy. cantariniluca@hotmail.com
authors.forename: L
authors.initials: L
authors.lastname: Cantarini
authors.forename: L
authors.initials: L
authors.lastname: Obici
authors.forename: G
authors.initials: G
authors.lastname: Simonini
authors.forename: R
authors.initials: R
authors.lastname: Cimaz
authors.forename: M R
authors.initials: MR
authors.lastname: Bacarelli
authors.forename: G
authors.initials: G
authors.lastname: Merlini
authors.forename: A
authors.initials: A
authors.lastname: Vitale
authors.forename: O M
authors.initials: OM
authors.lastname: Lucherini
authors.forename: M G
authors.initials: MG
authors.lastname: Brizi
authors.forename: M
authors.initials: M
authors.lastname: Galeazzi
authors.forename: A
authors.initials: A
authors.lastname: Fioravanti
mesh_terms: D052242:Adiponectin / Q000097:blood*; D000328:Adult; D000368:Aged; D000686:Amyloidosis / Q000097:blood / Q000235:genetics; D000704:Analysis of Variance; D016022:Case-Control Studies; D003430:Cross-Sectional Studies; D016207:Cytokines / Q000097:blood*; D018450:Disease Progression; D005260:Female; D005334:Fever; D020022:Genetic Predisposition to Disease; D056660:Hereditary Autoinflammatory Diseases / Q000097:blood* / Q000150:complications / Q000175:diagnosis / Q000235:genetics; D006801:Humans; D020738:Leptin / Q000097:blood*; D008297:Male; D008875:Middle Aged; D009154:Mutation; D054409:Nicotinamide Phosphoribosyltransferase / Q000097:blood*; D010641:Phenotype; D047888:Receptors, Tumor Necrosis Factor, Type I / Q000235:genetics*; D052243:Resistin / Q000097:blood*; D018570:Risk Assessment; D012307:Risk Factors; D012720:Severity of Illness Index; D055815:Young Adult
chemical_list: C499918:ADIPOQ protein, human; D052242:Adiponectin; D016207:Cytokines; D020738:Leptin; C499624:RETN protein, human; D047888:Receptors, Tumor Necrosis Factor, Type I; D052243:Resistin; C506235:TNFRSF1A protein, human; D054409:Nicotinamide Phosphoribosyltransferase; C085455:nicotinamide phosphoribosyltransferase, human