title: miR-183 inhibits the metastasis of osteosarcoma via downregulation of             the expression of Ezrin in F5M2 cells.
abstract: Osteosarcoma is the most common primary malignancy of bone in teenagers             and approximately 30% of patients develop lung metastasis, which is the leading             cause of mortality. Recent studies suggest that the Ezrin protein is correlated             with the metastatic potential of several malignant tumors. In our study, ectopic             overexpression of miR-183 repressed the expression levels of Ezrin and significantly             inhibited the motility and invasion of osteosarcoma cells. This suggests that             miR-183 may possibly play a tumor suppressor role in the metastasis of osteosarcoma             by downregulating Ezrin expression levels. These findings show that through inhibition             of Ezrin expression levels, miR-183 is significantly involved in cell migration             and invasion of osteosarcoma.
authors.affiliation: Department of Orthopaedic Surgery, Tangdu Hospital, The Fourth Military Medical University, Xi'an, Shaanxi 710038, PR China.
authors.forename: Haien
authors.initials: H
authors.lastname: Zhao
authors.forename: Mingjun
authors.initials: M
authors.lastname: Guo
authors.forename: Guangyi
authors.initials: G
authors.lastname: Zhao
authors.forename: Qiong
authors.initials: Q
authors.lastname: Ma
authors.forename: Baoan
authors.initials: B
authors.lastname: Ma
authors.forename: Xiuchun
authors.initials: X
authors.lastname: Qiu
authors.forename: Qingyu
authors.initials: Q
authors.lastname: Fan
mesh_terms: D017209:Apoptosis; D001859:Bone Neoplasms / Q000378:metabolism / Q000473:pathology*; D045744:Cell Line, Tumor; D002465:Cell Movement; D003598:Cytoskeletal Proteins / Q000235:genetics / Q000378:metabolism*; D015536:Down-Regulation; D015870:Gene Expression; D006801:Humans; D035683:MicroRNAs / Q000235:genetics / Q000378:metabolism / Q000502:physiology*; D009361:Neoplasm Invasiveness; D012516:Osteosarcoma / Q000378:metabolism / Q000556:secondary*; D034622:RNA Interference; D000099149:Ezrin
chemical_list: D003598:Cytoskeletal Proteins; D035683:MicroRNAs; D000099149:Ezrin; C533449:MIRN183 microRNA, human