title: The prevalence of metal-based drugs as therapeutic or diagnostic agents: beyond platinum.
abstract: Metal complexes and metal salts have a wide range of medicinal applications and are extensively administered to patients or purchased over the counter as a matter of routine. The abundance and variety of non-platinum metal complexes, which are approved for use as therapeutic or diagnostic agents, are highlighted. Current insights into the mechanism of action or indeed lack thereof of a selection of metallodrugs are discussed. Ultimately this perspective seeks to inspire chemists to tackle new challenges and raise awareness of opportunities in the area of inorganic therapeutic and diagnostic medicine.
authors.affiliation: Department of Basic Medical Sciences, Royal College of Surgeons in Ireland Medical University of Bahrain, Building No. 2441, Road 2835, Busaiteen 228, PO Box 15503, Adliya, Kingdom of Bahrain. dgaynor@rcsi-mub.com
authors.forename: Declan
authors.initials: D
authors.lastname: Gaynor
authors.forename: Darren M
authors.initials: DM
authors.lastname: Griffith
mesh_terms: D000889:Anti-Arrhythmia Agents / Q000737:chemistry / Q000627:therapeutic use; D000890:Anti-Infective Agents / Q000737:chemistry / Q000494:pharmacology; D000970:Antineoplastic Agents / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use; D000981:Antiprotozoal Agents / Q000737:chemistry / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects; D003287:Contrast Media / Q000737:chemistry; D056831:Coordination Complexes / Q000737:chemistry* / Q000378:metabolism / Q000627:therapeutic use; D005658:Fungi / Q000187:drug effects; D006801:Humans; D007891:Leishmania / Q000187:drug effects; D008279:Magnetic Resonance Imaging; D008670:Metals / Q000737:chemistry*; D009369:Neoplasms / Q000000981:diagnostic imaging / Q000188:drug therapy; D015514:Oncogene Proteins, Fusion / Q000737:chemistry / Q000378:metabolism; D010984:Platinum / Q000737:chemistry*; D049268:Positron-Emission Tomography; D011485:Protein Binding / Q000187:drug effects; D011859:Radiography; D019275:Radiopharmaceuticals / Q000737:chemistry
chemical_list: D000889:Anti-Arrhythmia Agents; D000890:Anti-Infective Agents; D000970:Antineoplastic Agents; D000981:Antiprotozoal Agents; D003287:Contrast Media; D056831:Coordination Complexes; D008670:Metals; D015514:Oncogene Proteins, Fusion; D019275:Radiopharmaceuticals; C093476:promyelocytic leukemia-retinoic acid receptor alpha fusion oncoprotein; D010984:Platinum