title: Measurement of barrier tissue integrity with an organic electrochemical transistor.
abstract: The integration of an organic electrochemical transistor with human barrier tissue cells provides a novel method for assessing toxicology of compounds in vitro. Minute variations in paracellular ionic flux induced by toxic compounds are measured in real time, with unprecedented temporal resolution and extreme sensitivity.
authors.affiliation: Department of Bioelectronics, Ecole Nationale Superieure des Mines, CMP-EMSE, MOC, 880 Rue de Mimet, Gardanne 13541, France.
authors.forename: Leslie H
authors.initials: LH
authors.lastname: Jimison
authors.forename: Scherrine A
authors.initials: SA
authors.lastname: Tria
authors.forename: Dion
authors.initials: D
authors.lastname: Khodagholy
authors.forename: Moshe
authors.initials: M
authors.lastname: Gurfinkel
authors.forename: Erica
authors.initials: E
authors.lastname: Lanzarini
authors.forename: Adel
authors.initials: A
authors.lastname: Hama
authors.forename: George G
authors.initials: GG
authors.lastname: Malliaras
authors.forename: Róisín M
authors.initials: RM
authors.lastname: Owens
mesh_terms: D001681:Biological Assay / Q000295:instrumentation*; D015374:Biosensing Techniques / Q000295:instrumentation*; D018938:Caco-2 Cells; D002470:Cell Survival / Q000187:drug effects*; D004867:Equipment Design; D019544:Equipment Failure Analysis; D000431:Ethanol / Q000633:toxicity*; D006801:Humans; D006861:Hydrogen Peroxide / Q000633:toxicity*; D009930:Organic Chemicals / Q000737:chemistry; D014173:Transistors, Electronic
chemical_list: D009930:Organic Chemicals; D000431:Ethanol; D006861:Hydrogen Peroxide