title: Seven newly identified loci for autoimmune thyroid disease.
abstract: Autoimmune thyroid disease (AITD), including Graves' disease (GD) and Hashimoto's thyroiditis (HT), is one of the most common of the immune-mediated diseases. To further investigate the genetic determinants of AITD, we conducted an association study using a custom-made single-nucleotide polymorphism (SNP) array, the ImmunoChip. The SNP array contains all known and genotype-able SNPs across 186 distinct susceptibility loci associated with one or more immune-mediated diseases. After stringent quality control, we analysed 103 875 common SNPs (minor allele frequency >0.05) in 2285 GD and 462 HT patients and 9364 controls. We found evidence for seven new AITD risk loci (P < 1.12 × 10(-6); a permutation test derived significance threshold), five at locations previously associated and two at locations awaiting confirmation, with other immune-mediated diseases.
authors.affiliation: Department of Medical Genetics, Cambridge Institute for Medical Research, Juvenile Diabetes Research Foundation/ Wellcome Trust Diabetes and Inflammation Laboratory, NIHR Cambridge Biomedical Research Centre, University of Cambridge, Addenbrooke’s Hospital, Cambridge, UK. jason.cooper@cimr.cam.ac.uk
authors.forename: Jason D
authors.initials: JD
authors.lastname: Cooper
authors.forename: Matthew J
authors.initials: MJ
authors.lastname: Simmonds
authors.forename: Neil M
authors.initials: NM
authors.lastname: Walker
authors.forename: Oliver
authors.initials: O
authors.lastname: Burren
authors.forename: Oliver J
authors.initials: OJ
authors.lastname: Brand
authors.forename: Hui
authors.initials: H
authors.lastname: Guo
authors.forename: Chris
authors.initials: C
authors.lastname: Wallace
authors.forename: Helen
authors.initials: H
authors.lastname: Stevens
authors.forename: Gillian
authors.initials: G
authors.lastname: Coleman
authors.forename: Jayne A
authors.initials: JA
authors.lastname: Franklyn
authors.forename: John A
authors.initials: JA
authors.lastname: Todd
authors.forename: Stephen C L
authors.initials: SC
authors.lastname: Gough
mesh_terms: D001327:Autoimmune Diseases / Q000235:genetics* / Q000276:immunology; D016022:Case-Control Studies; D002871:Chromosome Banding; D002874:Chromosome Mapping; D005260:Female; D056426:Genetic Loci; D020022:Genetic Predisposition to Disease; D006111:Graves Disease / Q000235:genetics* / Q000276:immunology; D050031:Hashimoto Disease / Q000235:genetics* / Q000276:immunology; D006801:Humans; D008297:Male; D020641:Polymorphism, Single Nucleotide; D013959:Thyroid Diseases / Q000235:genetics / Q000276:immunology