title: Fibroblast growth factor 23: state of the field and future directions.
abstract: Fibroblast growth factor 23 (FGF23) is a bone-derived hormone that regulates and is regulated by blood levels of phosphate and active vitamin D. Post-translational glycosylation by the enzyme GALNT3 and subsequent processing by furin have been demonstrated to be a regulated process that plays a role in regulating FGF23 levels. In physiologic states, FGF23 signaling is mediated by an FGF receptor and the coreceptor, Klotho. Recent work identifying a role for iron/hypoxia pathways in FGF23 physiology and their implications are discussed. Beyond its importance in primary disorders of mineral metabolism, recent work implicates FGF23 in renal disease-associated morbidity, as well as possible roles in cardiovascular disease and skeletal fragility.
authors.affiliation: Skeletal Clinical Studies Unit, Craniofacial and Skeletal Diseases Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD, USA.
authors.forename: Nisan
authors.initials: N
authors.lastname: Bhattacharyya
authors.forename: William H
authors.initials: WH
authors.lastname: Chong
authors.forename: Rachel I
authors.initials: RI
authors.lastname: Gafni
authors.forename: Michael T
authors.initials: MT
authors.lastname: Collins
mesh_terms: D000818:Animals; D001842:Bone and Bones / Q000378:metabolism; D000089703:Fibroblast Growth Factor-23; D005346:Fibroblast Growth Factors / Q000502:physiology*; D005966:Glucuronidase / Q000502:physiology; D006801:Humans; D019189:Iron Metabolism Disorders / Q000503:physiopathology; D007674:Kidney Diseases / Q000378:metabolism; D000090265:Klotho Proteins; D051379:Mice; D017468:Receptors, Fibroblast Growth Factor / Q000502:physiology; D014807:Vitamin D / Q000502:physiology
chemical_list: C000717427:FGF23 protein, human; C000717428:Fgf23 protein, mouse; D017468:Receptors, Fibroblast Growth Factor; D014807:Vitamin D; D005346:Fibroblast Growth Factors; D000089703:Fibroblast Growth Factor-23; D005966:Glucuronidase; D000090265:Klotho Proteins