title: Heterogeneity between primary colon carcinoma and paired lymphatic and             hepatic metastases.
abstract: Heterogeneity is one of the recognized characteristics of human tumors,             and occurs on multiple levels in a wide range of tumors. A number of studies have             focused on the heterogeneity found in primary tumors and related metastases with             the consideration that the evaluation of metastatic rather than primary sites             could be of clinical relevance. Numerous studies have demonstrated particularly             high rates of heterogeneity between primary colorectal tumors and their paired             lymphatic and hepatic metastases. It has also been proposed that the heterogeneity             between primary colon carcinomas and their paired lymphatic and hepatic metastases             may result in different responses to anticancer therapies. The heterogeneity in             primary colon carcinoma and corresponding metastases by genome‑wide gene expression             analysis has not been extensively studied. In the present study, we investigated             the differentially expressed genes between a primary colon carcinoma specimen             (obtained from a 40-year-old female colon carcinoma patient with lymphatic and             hepatic metastases) and its paired lymphatic and hepatic metastases by genome-wide             gene expression analysis using GeneChip HGU133Plus2.0 expression arrays. Our results             demonstrate that genome-wide gene expression varies between primary colon carcinoma             and its paired lymphatic and hepatic metastases.
authors.affiliation: Department of Gynecology and Obstetrics, Taizhou Hospital, Wenzhou Medical College, Linhai 317000, Zhejiang, PR China.
authors.forename: Huanrong
authors.initials: H
authors.lastname: Lan
authors.forename: Ketao
authors.initials: K
authors.lastname: Jin
authors.forename: Bojian
authors.initials: B
authors.lastname: Xie
authors.forename: Na
authors.initials: N
authors.lastname: Han
authors.forename: Binbin
authors.initials: B
authors.lastname: Cui
authors.forename: Feilin
authors.initials: F
authors.lastname: Cao
authors.forename: Lisong
authors.initials: L
authors.lastname: Teng
mesh_terms: D000328:Adult; D002277:Carcinoma / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D003110:Colonic Neoplasms / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D015342:DNA Probes / Q000378:metabolism; D005260:Female; D015870:Gene Expression; D015894:Genome, Human; D006801:Humans; D008113:Liver Neoplasms / Q000235:genetics / Q000378:metabolism* / Q000556:secondary; D008207:Lymphatic Metastasis; D020411:Oligonucleotide Array Sequence Analysis
chemical_list: D015342:DNA Probes