title: On-line measurement of propofol using membrane inlet ion mobility spectrometer.
abstract: The concentration of propofol in patient's exhaled air is an indicator of the anesthetic depth. In the present study, a membrane inlet ion mobility spectrometer (MI-IMS) was built for the on-line measurement of propofol. Compared with the direct sample introduction, the membrane inlet could eliminate the interference of moisture and improve the selectivity of propofol. Effects of membrane temperature and carrier gas flow rate on the sensitivity and response time have been investigated experimentally and theoretically. Under the optimized experimental conditions of membrane temperature 100 °C and carrier gas flow rate 200 mL min(-1), the calculated limit of detection (LOD) for propofol was 1 ppbv, and the calibration curve was linear in the range of 10-83 ppbv with a correlation coefficient (R(2)) of 0.993. Finally, the propofol concentration in an anaesthetized mouse exhaled air was monitored continuously to demonstrate the capability of MI-IMS in the on-line measurement of propofol in real samples.
authors.affiliation: Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian, Liaoning 116023, PR China.
authors.forename: Qinghua
authors.initials: Q
authors.lastname: Zhou
authors.forename: Weiguo
authors.initials: W
authors.lastname: Wang
authors.forename: Huaiwen
authors.initials: H
authors.lastname: Cang
authors.forename: Yongzhai
authors.initials: Y
authors.lastname: Du
authors.forename: Fenglei
authors.initials: F
authors.lastname: Han
authors.forename: Chuang
authors.initials: C
authors.lastname: Chen
authors.forename: Shasha
authors.initials: S
authors.lastname: Cheng
authors.forename: Jinghua
authors.initials: J
authors.lastname: Li
authors.forename: Haiyang
authors.initials: H
authors.lastname: Li
mesh_terms: D018686:Anesthetics, Intravenous / Q000008:administration & dosage / Q000032:analysis* / Q000493:pharmacokinetics; D000818:Animals; D001944:Breath Tests; D002138:Calibration; D045853:Exhalation; D006358:Hot Temperature; D006801:Humans; D007700:Kinetics; D057230:Limit of Detection; D008567:Membranes, Artificial; D051379:Mice; D015742:Propofol / Q000008:administration & dosage / Q000032:analysis* / Q000493:pharmacokinetics; D012825:Silicon; D018629:Spectrometry, Mass, Secondary Ion
chemical_list: D018686:Anesthetics, Intravenous; D008567:Membranes, Artificial; D015742:Propofol; D012825:Silicon