title: Outcome in 146 patients with paediatric acute myeloid leukaemia treated according to the AML99 protocol in the period 2003-06 from the Japan Association of Childhood Leukaemia Study.
abstract: The acute myeloid leukaemia (AML) 99 trial conducted previously in Japan for the treatment of de novo paediatric AML showed excellent results, with a 5-year overall survival (OS) and event-free survival (EFS) of 75·6% and 61·6%, respectively. To examine reproducibility of these results in another cohort, the outcome of 146 newly diagnosed AML paediatric patients prospectively registered in the Japan Association of Childhood Leukaemia Study (JACLS) from 2003 to 2006 was compared to that of 240 patients in the original AML 99 clinical trial. The 5-year EFS and OS achieved in the new cohort was 66·7 ± 4·0% and 77·7 ± 8·0% respectively, which were comparable to those obtained in the original AML 99 clinical trial, although less frequent core-binding factor (CBF) AML (29·5% vs. 37%) and an almost equal frequency of allogeneic haematopoietic stem cell transplantation (allo-HSCT) during first complete remission (16·5% vs. 19%) were observed. The 5-year EFS in patients with a normal karyotype (NK) (n = 35, 54·9 ± 15·1%) was inferior in the present cohort when compared to the original AML99 trial. This study confirmed the excellent outcome of the original AML99 protocol.
authors.affiliation: Department of Paediatrics, Kyoto Prefectural University of Medicine, Graduate School of Medical Science, Kyoto, Japan. imamura@koto.kpu-m.ac.jp
authors.forename: Toshihiko
authors.initials: T
authors.lastname: Imamura
authors.forename: Shotaro
authors.initials: S
authors.lastname: Iwamoto
authors.forename: Rie
authors.initials: R
authors.lastname: Kanai
authors.forename: Akira
authors.initials: A
authors.lastname: Shimada
authors.forename: Kiminori
authors.initials: K
authors.lastname: Terui
authors.forename: Yuko
authors.initials: Y
authors.lastname: Osugi
authors.forename: Ryoji
authors.initials: R
authors.lastname: Kobayashi
authors.forename: Akio
authors.initials: A
authors.lastname: Tawa
authors.forename: Yoshiyuki
authors.initials: Y
authors.lastname: Kosaka
authors.forename: Koji
authors.initials: K
authors.lastname: Kato
authors.forename: Hiroki
authors.initials: H
authors.lastname: Hori
authors.forename: Keizo
authors.initials: K
authors.lastname: Horibe
authors.forename: Megumi
authors.initials: M
authors.lastname: Oda
authors.forename: Souichi
authors.initials: S
authors.lastname: Adachi
mesh_terms: D000293:Adolescent; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage*; D002648:Child; D002675:Child, Preschool; D018572:Disease-Free Survival; D005260:Female; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D007223:Infant; D007564:Japan / Q000453:epidemiology; D015470:Leukemia, Myeloid, Acute / Q000401:mortality* / Q000628:therapy*; D008297:Male; D012189:Retrospective Studies; D015996:Survival Rate; D014184:Transplantation, Homologous