title: Total synthesis of incarvilleatone and incarviditone: insight into their biosynthetic pathways and structure determination.
abstract: A concise biomimetic total synthesis of incarvilleatone and incarviditone is achieved in one pot via the highly stereoselective hetero- and homodimerization of (±)-rengyolone, respectively. The structure of incarviditone is revised on the basis of spectroscopic and computational evidence.
authors.affiliation: The Comprehensive AIDS Research Center, Department of Pharmacology & Pharmaceutical Sciences, School of Medicine, Tsinghua University, Beijing 100084, China.
authors.forename: Kun
authors.initials: K
authors.lastname: Zhao
authors.forename: Gui-Juan
authors.initials: GJ
authors.lastname: Cheng
authors.forename: Hongzhi
authors.initials: H
authors.lastname: Yang
authors.forename: Hai
authors.initials: H
authors.lastname: Shang
authors.forename: Xinhao
authors.initials: X
authors.lastname: Zhang
authors.forename: Yun-Dong
authors.initials: YD
authors.lastname: Wu
authors.forename: Yefeng
authors.initials: Y
authors.lastname: Tang
mesh_terms: D001572:Benzofurans / Q000138:chemical synthesis* / Q000737:chemistry*; D053898:Biosynthetic Pathways; D005663:Furans / Q000737:chemistry*; D006574:Heterocyclic Compounds, 2-Ring / Q000737:chemistry*; D006576:Heterocyclic Compounds, 4 or More Rings / Q000138:chemical synthesis* / Q000737:chemistry*; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D013237:Stereoisomerism
chemical_list: D001572:Benzofurans; D005663:Furans; D006574:Heterocyclic Compounds, 2-Ring; D006576:Heterocyclic Compounds, 4 or More Rings; C509673:Rengyolone; C542670:incarviditone; C572693:incarvilleatone