title: The role of glycogen synthase in the development of hyperglycemia in type 2 diabetes: 'To store or not to store glucose, that's the question'.
abstract: This review deals with the role of glycogen storage in skeletal muscle for the development of insulin resistance and type 2 diabetes. Specifically, the role of the enzyme glycogen synthase, which seems to be locked in its hyperphosphorylated and inactivated state, is discussed. This defect seems to be secondary to ectopic lipid disposition in the muscle cells. These molecular defects are discussed in the context of the overall pathophysiology of hyperglycemia in type 2 diabetic subjects.
authors.affiliation: Department of Endocrinology, Odense University Hospital, Odense C, Denmark. henning.beck-nielsen@ouh.regionsyddanmark.dk
authors.forename: Henning
authors.initials: H
authors.lastname: Beck-Nielsen
mesh_terms: D003924:Diabetes Mellitus, Type 2 / Q000503:physiopathology*; D005947:Glucose / Q000378:metabolism; D006442:Glycated Hemoglobin / Q000378:metabolism; D006003:Glycogen / Q000378:metabolism; D006006:Glycogen Synthase / Q000187:drug effects / Q000502:physiology*; D006801:Humans; D006943:Hyperglycemia / Q000201:enzymology / Q000209:etiology; D007328:Insulin / Q000494:pharmacology; D007333:Insulin Resistance / Q000502:physiology*; D050356:Lipid Metabolism; D018482:Muscle, Skeletal / Q000503:physiopathology; D010766:Phosphorylation
chemical_list: D005947:Glucose; D006442:Glycated Hemoglobin; D006003:Glycogen; D006006:Glycogen Synthase; D007328:Insulin; C517652:hemoglobin A1c protein, human