title: Diagnostic accuracy of fine-needle aspiration cytology of the breast in Japan: report from the Working Group on the Accuracy of Breast Fine-Needle Aspiration Cytology of the Japanese Society of Clinical Cytology.
abstract: The Working Group of the Japanese Society of Clinical Cytology was assembled             to assess the current status of breast cytology in Japan by conducting a large-scale             survey regarding the accuracy of fine-needle aspiration biopsy (FNAB) in Japan.             We collected data and investigated the status of breast cytological diagnosis             at 12 different cooperating facilities in Japan, and re-evaluated their false-negative             and false-positive cases. Among 30,535 individuals who underwent a breast cytological             examination, analyses were conducted on 10,890 individuals (35.7%) in whom cytological             diagnoses were confirmed by histology. Among these patients, the cytological diagnosis             had an inadequate rate of 17.7%, an indeterminate rate of 7.8%, a positive predictive             value of 'malignancy suspected' cells of 92.4%, an absolute sensitivity of 76.7%,             a complete sensitivity of 96.7%, a specificity of 84.3%, a positive predictive             value of 'malignant' cells of 99.5%, a false-negative value of 3.31%, a false-positive             value of 0.25% and an accuracy rate of 88.0%. Subsequently, 297 false-negative             and 23 false-positive cases were re-evaluated and several factors were characterized             (i.e. histological type, tumor size and misread points). This survey collected             data from a large number of cases for breast FNAB. Based on our survey, the accuracy             of FNAB in Japan was relatively high compared with the goal of assessment of diagnostic             accuracy. However, there were some false-negative and false-positive cases. Improvements             in accuracy resulting from the learning points in the present study will lead             to more useful and reliable diagnostic tools in clinical practice.
authors.affiliation: Department of Pathology, Kurume University School of Medicine/Kurume University Medical Center, Kurume, Japan. rin@med.kurume-u.ac.jp
authors.forename: Rin
authors.initials: R
authors.lastname: Yamaguchi
authors.forename: Shin-ιchi
authors.initials: SΙ
authors.lastname: Tsuchiya
authors.forename: Takashi
authors.initials: T
authors.lastname: Koshikawa
authors.forename: Akinori
authors.initials: A
authors.lastname: Ishihara
authors.forename: Shinobu
authors.initials: S
authors.lastname: Masuda
authors.forename: Ichiro
authors.initials: I
authors.lastname: Maeda
authors.forename: Masafumi
authors.initials: M
authors.lastname: Takimoto
authors.forename: Masashi
authors.initials: M
authors.lastname: Kawamoto
authors.forename: Haruaki
authors.initials: H
authors.lastname: Satoh
authors.forename: Michihiko
authors.initials: M
authors.lastname: Narita
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Itoh
authors.forename: Takashi
authors.initials: T
authors.lastname: Kitamura
authors.forename: Yoshiko
authors.initials: Y
authors.lastname: Tsuda
authors.forename: Naoki
authors.initials: N
authors.lastname: Ogane
authors.forename: Eiji
authors.initials: E
authors.lastname: Abe
authors.forename: Katsuhide
authors.initials: K
authors.lastname: Ikeda
authors.forename: Takeshi
authors.initials: T
authors.lastname: Nakamura
authors.forename: Harumi
authors.initials: H
authors.lastname: Kamaguchi
authors.forename: Yoshiro
authors.initials: Y
authors.lastname: Tokoro
mesh_terms: D044963:Biopsy, Fine-Needle / Q000592:standards*; D001940:Breast / Q000166:cytology* / Q000473:pathology*; D001943:Breast Neoplasms / Q000175:diagnosis*; D005188:False Negative Reactions; D005189:False Positive Reactions; D005260:Female; D006801:Humans; D007564:Japan