title: Clinical and imaging findings in thalassemia patients with extramedullary hematopoiesis.
abstract: The purpose was to analyze the imaging features of thalassemia with extramedullary hematopoiesis in 17 patients. The 17 patients were analyzed and examined retrospectively by X-ray, ultrasonography, computed tomography, and magnetic resonance imaging. Nine cases appeared with hepatic enlargement; 12 cases presented with megalocardia or hypodensity; 15 cases had skeletal manifestations, with involvement of the ribs (66.7%), spine vertebra (40.0%), skull (46.7%), and other bones (20%). Five cases showed nonskeletal manifestations, and extramedullary hematopoiesis was found in three cases. A case presented with cholelithiasis, and hemosiderosis of the liver was found in three cases. The signs of the skeletal manifestations and nonskeletal manifestations may be useful for clinical diagnosis.
authors.affiliation: Department of Radiology, The First Affiliated Hospital, Guangzhou Medical University, Guangzhou, Guangdong, China.
authors.forename: Guangbin
authors.initials: G
authors.lastname: Zhu
authors.forename: Xiaomei
authors.initials: X
authors.lastname: Wu
authors.forename: Xuelin
authors.initials: X
authors.lastname: Zhang
authors.forename: Meiyou
authors.initials: M
authors.lastname: Wu
authors.forename: Qingsi
authors.initials: Q
authors.lastname: Zeng
authors.forename: Xinchun
authors.initials: X
authors.lastname: Li
mesh_terms: D000293:Adolescent; D000328:Adult; D002648:Child; D002675:Child, Preschool; D002769:Cholelithiasis / Q000175:diagnosis; D003952:Diagnostic Imaging; D005260:Female; D006411:Hematopoiesis, Extramedullary; D006486:Hemosiderosis / Q000175:diagnosis; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D012189:Retrospective Studies; D013789:Thalassemia / Q000175:diagnosis* / Q000473:pathology