title: Inhaled methoxyflurane for pain and anxiety relief during burn wound care procedures: an Australian case series.
abstract: Pain is a common and significant feature of burn injury. The use of intravenous opioids forms the mainstay of procedural burn pain management, but in an outpatient setting, the demand for novel agents that do not require parenteral access, are easy to administer and have a rapid onset are urgently needed. One such agent is the inhaled anaesthetic agent, methoxyflurane (MF). The aim of this study was to conduct a pilot investigation into the clinical effectiveness of MF inhaler on pain and anxiety scores in patients undergoing burn wound care procedures in an outpatient setting. A prospective case series involved recruiting patients undergoing a burn wound care procedure in an ambulatory burn care setting. Pain and anxiety were assessed using numerical rating scales. Overall, median numerical pain rating score was significantly higher post-dressing [pre-dressing: 2; interquartile range (IQR): 1-3 versus post-dressing: 3; IQR 1·5-4; P = 0·01], whereas median numerical anxiety score significantly reduced following the dressing (pre-dressing: 5; IQR 4-7 versus post-dressing: 2; IQR 1-2; P < 0·001). Our study suggests that there is a role for MF in the pain management armamentarium in those undergoing burn care procedures in the ambulatory care setting. However, there is an urgent need for larger case series and randomised controlled trials to determine its overall clinical effectiveness.
authors.affiliation: Victorian Adult Burns Service, The Alfred Hospital, Melbourne, Victoria, AustraliaSchool of Public Health & Preventive Medicine, Monash University, The Alfred Hospital, Melbourne, Victoria, AustraliaThe Alfred Hospital and Skin and Cancer Foundation, Melbourne, Victoria, AustraliaSchool of Medicine, Griffith University, Brisbane, Queensland, AustraliaDepartment of Surgery, Monash University, The Alfred Hospital, Melbourne, Victoria, Australia.
authors.forename: Jason
authors.initials: J
authors.lastname: Wasiak
authors.forename: Patrick D
authors.initials: PD
authors.lastname: Mahar
authors.forename: Eldho
authors.initials: E
authors.lastname: Paul
authors.forename: Hana
authors.initials: H
authors.lastname: Menezes
authors.forename: Anneliese B
authors.initials: AB
authors.lastname: Spinks
authors.forename: Heather
authors.initials: H
authors.lastname: Cleland
mesh_terms: D000280:Administration, Inhalation; D000328:Adult; D000553:Ambulatory Care; D018685:Anesthetics, Inhalation / Q000008:administration & dosage*; D001007:Anxiety / Q000188:drug therapy*; D002056:Burns / Q000503:physiopathology / Q000628:therapy*; D005260:Female; D006801:Humans; D008297:Male; D008733:Methoxyflurane / Q000008:administration & dosage*; D008875:Middle Aged; D010146:Pain / Q000188:drug therapy*; D010147:Pain Measurement; D010865:Pilot Projects; D011446:Prospective Studies
chemical_list: D018685:Anesthetics, Inhalation; D008733:Methoxyflurane