title: Complete genome sequence of Ikoma lyssavirus.
abstract: Lyssaviruses (family Rhabdoviridae) constitute one of the most important groups of viral zoonoses globally. All lyssaviruses cause the disease rabies, an acute progressive encephalitis for which, once symptoms occur, there is no effective cure. Currently available vaccines are highly protective against the predominantly circulating lyssavirus species. Using next-generation sequencing technologies, we have obtained the whole-genome sequence for a novel lyssavirus, Ikoma lyssavirus (IKOV), isolated from an African civet in Tanzania displaying clinical signs of rabies. Genetically, this virus is the most divergent within the genus Lyssavirus. Characterization of the genome will help to improve our understanding of lyssavirus diversity and enable investigation into vaccine-induced immunity and protection.
authors.affiliation: Wildlife Zoonoses & Vector-Borne Diseases Research Group, Animal Health & Veterinary Laboratories Agency, Addlestone, Surrey, United Kingdom.
authors.forename: Denise A
authors.initials: DA
authors.lastname: Marston
authors.forename: Richard J
authors.initials: RJ
authors.lastname: Ellis
authors.forename: Daniel L
authors.initials: DL
authors.lastname: Horton
authors.forename: Ivan V
authors.initials: IV
authors.lastname: Kuzmin
authors.forename: Emma L
authors.initials: EL
authors.lastname: Wise
authors.forename: Lorraine M
authors.initials: LM
authors.lastname: McElhinney
authors.forename: Ashley C
authors.initials: AC
authors.lastname: Banyard
authors.forename: Chanasa
authors.initials: C
authors.lastname: Ngeleja
authors.forename: Julius
authors.initials: J
authors.lastname: Keyyu
authors.forename: Sarah
authors.initials: S
authors.lastname: Cleaveland
authors.forename: Tiziana
authors.initials: T
authors.lastname: Lembo
authors.forename: Charles E
authors.initials: CE
authors.lastname: Rupprecht
authors.forename: Anthony R
authors.initials: AR
authors.lastname: Fooks
mesh_terms: D000818:Animals; D016679:Genome, Viral; D018114:Lyssavirus / Q000145:classification / Q000235:genetics* / Q000302:isolation & purification / Q000472:pathogenicity; D008969:Molecular Sequence Data; D012367:RNA, Viral / Q000235:genetics; D018353:Rhabdoviridae Infections / Q000662:veterinary / Q000821:virology; D013636:Tanzania; D045949:Viverridae / Q000821:virology; D015047:Zoonoses / Q000821:virology
chemical_list: D012367:RNA, Viral