title: Antiviral effect of matrine against human enterovirus 71.
abstract: Human enterovirus 71, a member of the Picornaviridae family, is one of the major causative agent of hand, foot and mouth disease in children less than six years old. This illness has caused mortalities in large-scale outbreaks in the Asia-Pacific region in recent years. No vaccine or antiviral therapy is available. In this study, antiviral effect of matrine against enterovirus 71 were evaluated in vitro and in vivo. Matrine could suppress the viral RNA copy number on rhabdomyosarcoma cells. Moreover, matrine treatment of mice challenged with a lethal dose of enterovirus 71 reduced the mortality and relieved clinical symptoms. The results showed that matrine may represent a potential therapeutic agent for enterovirus 71 infection.
authors.affiliation: Key Laboratory of Human Diseases Comparative Medicine, Ministry of Health, Institute of Laboratory Animal Science, Chines Academy of Medical Science & Comparative Medicine Centre, Peking Union Medical College, Beijing 100021, China.
authors.forename: Yajun
authors.initials: Y
authors.lastname: Yang
authors.forename: Jinghui
authors.initials: J
authors.lastname: Xiu
authors.forename: Xu
authors.initials: X
authors.lastname: Zhang
authors.forename: Liangfeng
authors.initials: L
authors.lastname: Zhang
authors.forename: Kai
authors.initials: K
authors.lastname: Yan
authors.forename: Chuan
authors.initials: C
authors.lastname: Qin
authors.forename: Jiangning
authors.initials: J
authors.lastname: Liu
mesh_terms: D000470:Alkaloids / Q000494:pharmacology* / Q000627:therapeutic use; D000818:Animals; D000998:Antiviral Agents / Q000494:pharmacology* / Q000627:therapeutic use; D002460:Cell Line; D029821:Enterovirus A, Human / Q000187:drug effects* / Q000235:genetics*; D006232:Hand, Foot and Mouth Disease / Q000188:drug therapy* / Q000517:prevention & control / Q000821:virology; D006801:Humans; D051379:Mice; D011807:Quinolizines / Q000494:pharmacology* / Q000627:therapeutic use; D012367:RNA, Viral / Q000032:analysis*; D019562:Viral Load / Q000187:drug effects; D014779:Virus Replication / Q000187:drug effects; D000093842:Matrines
chemical_list: D000470:Alkaloids; D000998:Antiviral Agents; D011807:Quinolizines; D012367:RNA, Viral; D000093842:Matrines