title: Outcomes of adult patients with relapsed acute lymphoblastic leukemia following frontline treatment with a pediatric regimen.
abstract: We analyzed the outcome of 46 patients with acute lymphoblastic leukemia (ALL) who relapsed following treatment with a pediatric-based protocol; 34 received intensive re-induction chemotherapy, with a CR2 rate of 62%, median overall survival (OS) 7.8 months, median relapse-free survival 5.2 months and one year OS 19%. Allogeneic HSCT was performed in 8 patients in CR2/3, with a median OS 2.2 months. OS was superior in patients who relapsed after completion of chemotherapy, compared to those relapsing on treatment. The outcome of adult ALL relapsing after treatment was therefore poor, and novel salvage strategies are needed to improve outcomes.
authors.affiliation: Department of Medical Oncology and Hematology, Princess Margaret Hospital, University of Toronto, Toronto, ON, Canada.
authors.forename: Elena
authors.initials: E
authors.lastname: Liew
authors.forename: Eshetu G
authors.initials: EG
authors.lastname: Atenafu
authors.forename: Aaron D
authors.initials: AD
authors.lastname: Schimmer
authors.forename: Karen W L
authors.initials: KW
authors.lastname: Yee
authors.forename: Andre C
authors.initials: AC
authors.lastname: Schuh
authors.forename: Mark D
authors.initials: MD
authors.lastname: Minden
authors.forename: Vikas
authors.initials: V
authors.lastname: Gupta
authors.forename: Joseph M
authors.initials: JM
authors.lastname: Brandwein
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage*; D003131:Combined Modality Therapy; D005260:Female; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D008297:Male; D008875:Middle Aged; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000401:mortality / Q000473:pathology / Q000628:therapy*; D012008:Recurrence; D012074:Remission Induction; D016879:Salvage Therapy; D016019:Survival Analysis; D014184:Transplantation, Homologous; D016896:Treatment Outcome