title: Effect of platelet-rich plasma on bone healing of fresh frozen bone allograft in mandibular defects: a histomorphometric study in dogs.
abstract: OBJECTIVE
  This study histologically analyzed the healing of fresh frozen bone allograft (FFBA) with or without platelet-rich plasma (PRP) in bony defects surgically created in the mandible of dogs.
  
  
  METHODS
  Bilateral resection defects were surgically created on the inferior border of the mandible in 10 dogs. The defects were randomly divided into three groups: C (the defect was filled by blood clot only), FFBA (the defect was filled with particulate FFBA), and FFBA/PRP (the defect was filled with particulate FFBA combined with PRP). The animals were euthanized at 12 weeks post-surgery. Histomorphometric and histological analyses were performed. Data were statistically analyzed using Friedman test and Dunn test (P < 0.05).
  
  
  RESULTS
  Group FFBA/PRP presented a statistically greater mineralized bone area and a smaller marrow bone area than Groups FFBA and C.
  
  
  CONCLUSIONS
  The use of PRP improved the incorporation of FFBA, increasing the density of newly formed bone at 12 weeks post-surgery.
authors.affiliation: Department of Surgery and Bucco-Maxillofacial Traumatology and Periodontology, Ribeirao Preto School of Dentistry, University of Sao Paulo - USP, Ribeirão Preto, SP, Brazil.
authors.forename: Michel R
authors.initials: MR
authors.lastname: Messora
authors.forename: Maria J H
authors.initials: MJ
authors.lastname: Nagata
authors.forename: Natália M
authors.initials: NM
authors.lastname: Pola
authors.forename: Natália
authors.initials: N
authors.lastname: de Campos
authors.forename: Stephen E
authors.initials: SE
authors.lastname: Fucini
authors.forename: Flávia A C
authors.initials: FA
authors.lastname: Furlaneto
mesh_terms: D064591:Allografts; D000818:Animals; D001861:Bone Regeneration / Q000187:drug effects*; D016025:Bone Transplantation; D004285:Dogs; D005269:Femur / Q000637:transplantation; D008297:Male; D008334:Mandible / Q000601:surgery*; D010976:Platelet Count; D053657:Platelet-Rich Plasma; D014945:Wound Healing / Q000187:drug effects*