title: A review on noscapine, and its impact on heme metabolism.
abstract: This review introduces the Noscapine, which is being used as an antitussive drug for a long time has been recently discovered as a novel tubulin-binding, anti-angiogenic anticancer drug that causes cell cycle arrest and induces apoptosis in cancer cells both in vitro as well as in vivo. Noscapine is a multifunctional molecule i.e. it possesses various functional moieties. We maneuvered various amenable sites and have synthesized analogs, which might prove to be more efficacious and less cytotoxic. Moreover, development of oral controlled release anticancer formulation of noscapine is severely hampered due to short biological half-life (<2-h), poor absorption, low aqueous solubility, and extensive first pass metabolism, thereby requiring large doses for effective treatment.
authors.affiliation: Dr. B. R. Ambedkar Center for Biomedical Research, University of Delhi, Delhi-110007, India.
authors.forename: Harpal
authors.initials: H
authors.lastname: Singh
authors.forename: Prashant
authors.initials: P
authors.lastname: Singh
authors.forename: Kamlesh
authors.initials: K
authors.lastname: Kumari
authors.forename: Ankush
authors.initials: A
authors.lastname: Chandra
authors.forename: Sujata K
authors.initials: SK
authors.lastname: Dass
authors.forename: Ramesh
authors.initials: R
authors.lastname: Chandra
mesh_terms: D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000494:pharmacology* / Q000627:therapeutic use; D000996:Antitussive Agents / Q000494:pharmacology* / Q000627:therapeutic use; D002453:Cell Cycle; D006418:Heme / Q000378:metabolism*; D006801:Humans; D008870:Microtubules; D009369:Neoplasms / Q000188:drug therapy / Q000378:metabolism; D009665:Noscapine / Q000494:pharmacology* / Q000627:therapeutic use
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D000996:Antitussive Agents; D006418:Heme; D009665:Noscapine