title: DNA demethylation by TDG.
abstract: DNA methylation has long been considered a very stable DNA modification in mammals that could only be removed by replication in the absence of remethylation - that is, by mere dilution of this epigenetic mark (so-called passive DNA demethylation). However, in recent years, a significant number of studies have revealed the existence of active processes of DNA demethylation in mammals, with important roles in development and transcriptional regulation, allowing the molecular mechanisms of active DNA demethylation to be unraveled. In this article, we review the recent literature highlighting the prominent role played in active DNA demethylation by base excision repair and especially by TDG.
authors.affiliation: Cancer Biology Program, Epigenetics & Progenitor Cells Program, Fox Chase Cancer Center, PA 19111, USA.
authors.forename: Shannon R
authors.initials: SR
authors.lastname: Dalton
authors.forename: Alfonso
authors.initials: A
authors.lastname: Bellacosa
mesh_terms: D000818:Animals; D018899:CpG Islands; D019175:DNA Methylation / Q000235:genetics*; D004260:DNA Repair / Q000235:genetics; D005786:Gene Expression Regulation; D051379:Mice; D044502:Thymine DNA Glycosylase / Q000235:genetics* / Q000378:metabolism; D014158:Transcription, Genetic
chemical_list: D044502:Thymine DNA Glycosylase