title: Synthesis, spectroscopic, thermal and antimicrobial studies of toluene-3,4-dithiolatoarsenic(III) derivatives with some oxygen and sulphur donor ligands.
abstract: Replacement reactions of toluene-3,4-dithiolatoarsenic(III) chloride with oxygen and sulphur donor ligands like benzoic acid, thiobenzoic acid, anhydrous sodium acetate, thioacetic acid, phenol, thiophenol, sodium salicylate and thio glycolic acid in 1:1 molar ratio as well as disodium oxalate in 2:1 molar ratio in refluxing anhydrous benzene yielded toluene-3,4-dithiolatoarsenic(III) mono oxo or thio carboxylic or phenolic derivatives of the general formula SC(6)H(3)(CH(3))SAsR {where R=OOCC(6)H(5), SOCC(6)H(5), OOCCH(3), SOCCH(3), OC(6)H(5), SC(6)H(5), OOCC(6)H(4)(OH), SCH(2)COOH} and SC(6)H(3)(CH(3))SAsOOC-COOAsS(CH(3))C(6)H(3)S. These synthesized derivatives are yellow, yellow-brown solids/ liquids and are soluble in common organic solvents like benzene, chloroform, dichloromethane, dimethyl formamide, dimethyl sulphoxide etc. These derivatives have been characterized by melting point determination, molecular weight determination, elemental analysis (C, H, S and As), spectral {UV, IR, NMR ((1)H and (13)C), ESI-Mass, SEM and powder X-ray diffraction} and thermal (TGA, DTA and DSC) studies. Some of these compounds have been screened for their antimicrobial activities using the disc diffusion method. These derivatives have shown good activity as antibacterial and antifungal agents on some selected bacterial and fungal strains, which increased on increasing the concentration. Chloroamphenicol and terbinafin were used as standards for the comparison.
authors.affiliation: School of Chemical Sciences, Devi Ahilya University, Takshashila Campus, Khandwa Road, Indore 452 001, India. hpsc@rediffmail.com
authors.forename: H P S
authors.initials: HP
authors.lastname: Chauhan
authors.forename: Sumit
authors.initials: S
authors.lastname: Bhatiya
mesh_terms: D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D001152:Arsenicals / Q000737:chemistry*; D001419:Bacteria / Q000187:drug effects; D002152:Calorimetry, Differential Scanning; D004583:Electrons; D005658:Fungi / Q000187:drug effects; D008024:Ligands; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests; D008855:Microscopy, Electron, Scanning; D010100:Oxygen / Q000737:chemistry*; D011208:Powders; D021241:Spectrometry, Mass, Electrospray Ionization; D013055:Spectrophotometry, Infrared; D013455:Sulfur / Q000737:chemistry*; D013696:Temperature; D013818:Thermogravimetry; D014050:Toluene / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D014961:X-Ray Diffraction
chemical_list: D000900:Anti-Bacterial Agents; D001152:Arsenicals; D008024:Ligands; D011208:Powders; C578322:toluene-3,4-dithiolatoarsenic(III); D014050:Toluene; D013455:Sulfur; D010100:Oxygen