title: One-pot synthesis of spheres-on-sphere silica particles from a single precursor for fast HPLC with low back pressure.
abstract: Spheres-on-sphere (SOS) silica particles are prepared in a one-pot scalable synthesis from mercaptopropyltrimethoxysilane with hydrophilic polymer and cationic surfactant under alkaline conditions. The SOS particles exhibit solid-core porous-shell properties. The fast separation of small molecules and proteins with low back pressure are demonstrated by high-performance liquid chromatography (HPLC) for the columns packed with SOS-particles.
authors.affiliation: Department of Chemistry, University of Liverpool, Liverpool, UK.
authors.forename: Adham
authors.initials: A
authors.lastname: Ahmed
authors.forename: Harald
authors.initials: H
authors.lastname: Ritchie
authors.forename: Peter
authors.initials: P
authors.lastname: Myers
authors.forename: Haifei
authors.initials: H
authors.lastname: Zhang
mesh_terms: D002851:Chromatography, High Pressure Liquid / Q000379:methods*; D008422:Materials Testing; D008863:Microspheres; D016062:Porosity; D011312:Pressure; D011506:Proteins / Q000032:analysis* / Q000737:chemistry*; D012822:Silicon Dioxide / Q000737:chemistry*
chemical_list: D011506:Proteins; D012822:Silicon Dioxide