title: Neuroimmune mechanisms of depression in heart failure.
abstract: Heart failure (HF) is a major and costly public health concern, and its prognosis is grim-with high hospitalization and mortality rates. It is well documented that HF patients experience disproportionately high rates of depression and that depressed HF patients have worse clinical outcomes than their non-depressed counterparts. The purpose of this chapter is to introduce the reader to the study of depression in HF, and how psychoneuroimmunologic principals have been applied to further elucidate the mechanisms (i.e., neurohormonal and cytokine activation) linking these co-morbid disorders.
authors.affiliation: Department of Psychiatry, University of California at San Diego, San Diego, CA, USA.
authors.forename: Jessica A
authors.initials: JA
authors.lastname: Jiménez
authors.forename: Paul J
authors.initials: PJ
authors.lastname: Mills
mesh_terms: D000818:Animals; D015897:Comorbidity; D016207:Cytokines / Q000276:immunology; D003863:Depression / Q000150:complications* / Q000453:epidemiology / Q000276:immunology / Q000503:physiopathology*; D006333:Heart Failure / Q000150:complications* / Q000453:epidemiology / Q000276:immunology / Q000503:physiopathology*; D006801:Humans; D007111:Immunity, Cellular; D007249:Inflammation / Q000150:complications / Q000453:epidemiology / Q000276:immunology / Q000503:physiopathology; D015213:Neuroimmunomodulation; D011598:Psychoneuroimmunology; D012084:Renin-Angiotensin System
chemical_list: D016207:Cytokines