title: Whole-body vibration decreases the proliferativeb response of TCD4(+) cells in elderly individuals with knee osteoarthritis.
abstract: The aim of this study was to investigate the effect of adding whole-body vibration (WBV; frequency = 35 to 40 Hz; amplitude = 4 mm) to squat training on the T-cell proliferative response of elderly patients with osteoarthritis (OA) of the knee. This study was a randomized controlled trial in which the selected variables were assessed before and after 12 weeks of training. Twenty-six subjects (72 ± 5 years of age) were divided into three groups: 1) squat training with WBV (WBV, N = 8); 2) squat training without WBV (N = 10), and 3) a control group (N = 8). Women who were ≥60 years of age and had been diagnosed with OA in at least one knee were eligible. The intervention consisted of 12 uninterrupted weeks of squatting exercise training performed 3 times/week. Peripheral blood mononuclear cells were obtained from peripheral blood collected before and after training. The proliferation of TCD4+ and TCD8+ cells was evaluated by flow cytometry measuring the carboxyfluorescein succinimidyl ester fluorescence decay before and after the intervention (∆). The proliferative response of TCD4+ cells (P = 0.02, effect size = 1.0) showed a significant decrease (23%) in the WBV group compared to the control group, while there was no difference between groups regarding the proliferative response of TCD8+ cells (P = 0.12, effect size = 2.23). The data suggest that the addition of WBV to squat exercise training might modulate T-cell-mediated immunity, minimizing or slowing disease progression in elderly patients with OA of the knee.
authors.affiliation: Departamento de Fisioterapia, Faculdade de Ciências Biológicas e da Saúde, Universidade Federal dos Vales do Jequitinhonha e Mucuri, Diamantina, MG, Brasil.
authors.forename: R
authors.initials: R
authors.lastname: Tossige-Gomes
authors.forename: N C P
authors.initials: NC
authors.lastname: Avelar
authors.forename: A P
authors.initials: AP
authors.lastname: Simão
authors.forename: C D C
authors.initials: CD
authors.lastname: Neves
authors.forename: G E A
authors.initials: GE
authors.lastname: Brito-Melo
authors.forename: C C
authors.initials: CC
authors.lastname: Coimbra
authors.forename: E
authors.initials: E
authors.lastname: Rocha-Vieira
authors.forename: A C R
authors.initials: AC
authors.lastname: Lacerda
mesh_terms: D000368:Aged; D015496:CD4-Positive T-Lymphocytes / Q000502:physiology*; D016022:Case-Control Studies; D049109:Cell Proliferation; D018450:Disease Progression; D005081:Exercise Therapy; D005260:Female; D005434:Flow Cytometry; D006801:Humans; D008297:Male; D008875:Middle Aged; D053580:Muscle Strength / Q000502:physiology*; D020370:Osteoarthritis, Knee / Q000628:therapy*; D055070:Resistance Training / Q000379:methods*; D014732:Vibration / Q000627:therapeutic use*; D016138:Walking