title: Risk factors for new vertebral fractures after percutaneous vertebroplasty in patients with osteoporosis: a prospective study.
abstract: OBJECTIVE
  To determine the risk factors for new vertebral compression fractures (VCFs) following percutaneous vertebroplasty (PV) in patients with osteoporosis.
  
  
  METHODS
  This prospective study included 132 consecutive patients with osteoporosis treated with PV in a single institution over 46 months from March 2005 to December 2008. Multivariable logistic regression and univariate analysis were employed to identify risk factors for new VCFs after PV, including patient demographic data, parameters of the initial and new fractured vertebrae, procedure-related information, and follow-up data.
  
  
  RESULTS
  During the follow-up period (22.4 months ± 12.1), 80 new vertebral fractures occurred in 36 (27.3%) patients. Multivariate analysis showed that number of VCFs per time frame, computed tomography (CT) value of nonfractured vertebrae (T11-L2), activity level after discharge, duration of follow-up, and cement distribution in the inferior part of the vertebral body or close to the endplate were statistically correlated with new fractures (odds ratios, 2.63, 0.96, 3.59, 1.00, 0.30, and 0.05; P = .006, P = .001, P = .007, P = .004, P = .021 and P = .029). Univariate analysis showed preexisting old VCFs were correlated with new VCFs (P = .045). Subsequent compression fractures in adjacent vertebrae (45 of 80) occurred more frequently and sooner than nonadjacent vertebral fractures (both P < .05).
  
  
  CONCLUSIONS
  The incidence of new VCFs after PV is relatively high and affected by several risk factors that are related to both the PV procedure and the natural course of osteoporosis.
authors.affiliation: Department of Radiology, Southeast University, Nanjing , China.
authors.forename: Wen-Gui
authors.initials: WG
authors.lastname: Liu
authors.forename: Shi-Cheng
authors.initials: SC
authors.lastname: He
authors.forename: Gang
authors.initials: G
authors.lastname: Deng
authors.forename: Jin-He
authors.initials: JH
authors.lastname: Guo
authors.forename: Wen
authors.initials: W
authors.lastname: Fang
authors.forename: Guang-Yu
authors.initials: GY
authors.lastname: Zhu
authors.forename: Gao-Jun
authors.initials: GJ
authors.lastname: Teng
mesh_terms: D000368:Aged; D002681:China; D005260:Female; D050815:Fractures, Compression / Q000000981:diagnostic imaging / Q000209:etiology / Q000601:surgery*; D006801:Humans; D015994:Incidence; D016015:Logistic Models; D008297:Male; D015999:Multivariate Analysis; D016017:Odds Ratio; D010024:Osteoporosis / Q000150:complications*; D011446:Prospective Studies; D012008:Recurrence; D018570:Risk Assessment; D012307:Risk Factors; D016103:Spinal Fractures / Q000000981:diagnostic imaging / Q000209:etiology / Q000601:surgery*; D013997:Time Factors; D014057:Tomography, X-Ray Computed; D054854:Vertebroplasty / Q000009:adverse effects* / Q000379:methods