title: The effect of low-magnitude, high-frequency vibration stimuli on the bone healing of rat incisor extraction socket.
abstract: Effects of small vibration stimuli on bone formation have been reported. In the present study, we used morphological and morphometric procedures to elucidate whether low-magnitude, high-frequency (LMHF) vibration stimuli could enhance the bone healing of rat incisor extraction sockets. After extraction of incisors from six-week-old rats, animals were assigned into a control group and two experimental groups to receive 50 Hz stimuli at either 0.05 mm or 0.2 mm peak-to-peak for an hour/day. LMHF vibration stimuli were generated by placing the mandibles of the animals onto a vibration generator. All groups were subdivided into two, according to the study periods (1 and 3 weeks). After the study period, undecalcified ground sections were taken and morphological and morphometric analyses performed. At both 1 and 3 weeks, newly formed bone was observed mainly in the upper wall of the extraction socket in all groups. Morphometric analyses revealed that the trabecular thickness in both experimental groups at 1 week was significantly greater than that in the control. LMHF vibration stimuli had a positive effect on bone at the early stage of bone healing, particularly in trabecular thickness, at the incisor extraction socket.
authors.affiliation: Section of Implant and Rehabilitative Dentistry, Division of Oral Rehabilitation, Kyushu University, Fukuoka, Japan.
authors.forename: Takashi
authors.initials: T
authors.lastname: Kono
authors.forename: Yasunori
authors.initials: Y
authors.lastname: Ayukawa
authors.forename: Yasuko
authors.initials: Y
authors.lastname: Moriyama
authors.forename: Kosaku
authors.initials: K
authors.lastname: Kurata
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Takamatsu
authors.forename: Kiyoshi
authors.initials: K
authors.lastname: Koyano
mesh_terms: D000818:Animals; D001842:Bone and Bones / Q000473:pathology / Q000502:physiology*; D007180:Incisor; D008297:Male; D010012:Osteogenesis; D051381:Rats; D017208:Rats, Wistar; D014081:Tooth Extraction; D014732:Vibration / Q000627:therapeutic use*; D014945:Wound Healing