title: Comparison of the cytotoxic effects of enantiopure PPAPs, including nemorosone and clusianone.
abstract: The synthesis of an unnatural polyprenylated acylphloroglucinol (PPAP), regioisomeric with nemorosone and clusianone, has been accomplished. The separated enantiomers of this new PPAP, along with those of nemorosone and clusianone, have been screened for activity against HeLa (cervix carcinoma), MIA-PaCa-2 (pancreatic carcinoma), and MCF7 (mamma carcinoma) cancer cell lines. All of the isomers examined gave surprisingly similar results in the screens.
authors.affiliation: School of Chemistry, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK. n.simpkins@bham.ac.uk
authors.forename: Nigel S
authors.initials: NS
authors.lastname: Simpkins
authors.forename: Frank
authors.initials: F
authors.lastname: Holtrup
authors.forename: Vincent
authors.initials: V
authors.lastname: Rodeschini
authors.forename: James D
authors.initials: JD
authors.lastname: Taylor
authors.forename: Robert
authors.initials: R
authors.lastname: Wolf
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D001577:Benzophenones / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D016227:Benzoquinones; D001643:Bridged Bicyclo Compounds / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D045744:Cell Line, Tumor; D004305:Dose-Response Relationship, Drug; D004354:Drug Screening Assays, Antitumor; D006367:HeLa Cells; D006801:Humans; D061986:MCF-7 Cells; D008968:Molecular Conformation; D013237:Stereoisomerism; D013329:Structure-Activity Relationship
chemical_list: C118110:7-epiclusianone; D000970:Antineoplastic Agents; D001577:Benzophenones; D016227:Benzoquinones; D001643:Bridged Bicyclo Compounds; C437463:nemorosone