title: Differential effects of hGH and IGF-I on body proportions.
abstract: The differential growth effects of hGH and IGF-I on the upper/lower (U/L) body segment in relation to height (Ht) were analyzed in 15 patients with isolated Growth hormone deficiency (IGHD,:7M, 8F) mean age 5.0 +/- 3.2 (SD) years treated with hGH; 21 patients with multiple pituitary hormone deficiency including growth hormone (MPHD: 14M, 7F) aged 10.0 +/- 3.8, treated with hGH; 9 patients with Laron Syndrome (LS) (4M,5F) aged 6.9 +/- 5.6 years treated with IGF-I; 9 boys with intrauterine growth retardation (IUGR) aged 6.3 +/- 1.25 years treated by hGH; and 22 boys with idiopathic short stature (ISS) aged 8.0 +/- 1.55 years treated by hGH. The dose of hGH was 33 microg/kg/day, that of IGF-I 180-200 microg/kg/day.
  
  
  RESULTS
  the U/L body segment ratio in IGHD patients decreased from 2.3 +/- 0.7 to 1.1 +/- 0.7 (p <0.001), and the Ht SDS increased from -4.9 +/- 1.3 to 2.3 +/- 1 (p < 0.001) following treatment. In MPHD patients the U/L body segment decreased from 1.1 +/- 1.1 to -0.6 +/- 1.0 (p < 0.001), and the Ht SDS increased from -3.3 +/- 1.4 to -2.5 +/- 1.0 (p < 0.009). In the LS group the U/L body segment ratio did not change with IGF-I treatment but Ht improved from -6.1 +/- 1.3 to -4.6 +/- 1.2 (p < 0.001), The differential growth response of the children with IUGR and with ISS resembled that of the children with LS.
  
  
  CONCLUSIONS
  hGH and IGF-I act differentially on the spine and limbs.
authors.affiliation: Endocrinology and Diabetes Research Unit, Schneider Children's Hospital, WHO Collaborating Center for Diabetes in Youth Petah Tikva and Sackler School of Medicine, Tel Aviv, Israel. laronz@clalit.org.il
authors.forename: Zvi
authors.initials: Z
authors.lastname: Laron
authors.forename: Aviva
authors.initials: A
authors.lastname: Silbergeld
authors.forename: Rivka
authors.initials: R
authors.lastname: Kauli
mesh_terms: D000293:Adolescent; D001827:Body Height / Q000187:drug effects*; D049628:Body Size / Q000187:drug effects*; D002648:Child; D002675:Child, Preschool; D005260:Female; D005317:Fetal Growth Retardation; D006130:Growth Disorders / Q000188:drug therapy*; D019382:Human Growth Hormone / Q000008:administration & dosage* / Q000172:deficiency*; D006801:Humans; D007223:Infant; D007334:Insulin-Like Growth Factor I / Q000008:administration & dosage*; D046150:Laron Syndrome / Q000188:drug therapy; D008297:Male; D010907:Pituitary Hormones / Q000172:deficiency
chemical_list: D010907:Pituitary Hormones; D019382:Human Growth Hormone; D007334:Insulin-Like Growth Factor I