title: Expression of proteasome activator REGγ in human laryngeal carcinoma and associations with tumor suppressor proteins.
abstract: The functional significance of the proteasome activator REGγ in the regulation of cell proliferation and apoptosis has been recognized. However, pathological contributions to tumor development remain to be elucidated. Both oncogenic proteins and tumor suppressors are targeted by REGγ for proteasomal degradation. It has been proposed that the role of the REGγ in the pathogenesis of cancer is cell- and context-specific. In this study, we aimed to explore the potential involvement of REGγ in laryngeal carcinomas, comparing protein expression in tumor and adjacent tissues by immunohistochemical staining and Western blot analysis. We also characterized the correlation between the expression of REGγ and the previously identified substrates p53 and p21. We showed that REGγ was abnormally highly expressed in cancer tissues. Statistical analysis revealed that there was a positive relationship between the level of REGγ and the expression of p53 and p21. Our study suggests that REγ overexpression can facilitate the growth of laryngeal cancer cells.
authors.affiliation: Department of Otorhinolaryngology and Translational Neuroscience Center, West China Hospital of Sichuan University, China.
authors.forename: Li-Ping
authors.initials: LP
authors.lastname: Li
authors.forename: Wei-Bo
authors.initials: WB
authors.lastname: Cheng
authors.forename: Hong
authors.initials: H
authors.lastname: Li
authors.forename: Wen
authors.initials: W
authors.lastname: Li
authors.forename: Hui
authors.initials: H
authors.lastname: Yang
authors.forename: Ding-Hou
authors.initials: DH
authors.lastname: Wen
authors.forename: Yue-Di
authors.initials: YD
authors.lastname: Tang
mesh_terms: D000368:Aged; D017209:Apoptosis; D001324:Autoantigens / Q000096:biosynthesis* / Q000378:metabolism; D049109:Cell Proliferation; D050759:Cyclin-Dependent Kinase Inhibitor p21 / Q000096:biosynthesis*; D006801:Humans; D007822:Laryngeal Neoplasms / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D046988:Proteasome Endopeptidase Complex / Q000096:biosynthesis* / Q000378:metabolism; D016159:Tumor Suppressor Protein p53 / Q000096:biosynthesis*; D025521:Tumor Suppressor Proteins / Q000378:metabolism
chemical_list: D001324:Autoantigens; C493956:CDKN1A protein, human; D050759:Cyclin-Dependent Kinase Inhibitor p21; C099558:Ki antigen; D016159:Tumor Suppressor Protein p53; D025521:Tumor Suppressor Proteins; D046988:Proteasome Endopeptidase Complex