title: Feasibility study on effect and stability of adaptive radiotherapy on kilovoltage cone beam CT.
abstract: BACKGROUND
  We have analyzed the stability of CT to density curve of kilovoltage cone-beam computerized tomography (kV CBCT) imaging modality over the period of six months. We also, investigated the viability of using image value to density table (IVDT) generated at different time, for adaptive radiotherapy treatment planning. The consequences of target volume change and the efficacy of kV CBCT for adaptive planning issues is investigated.  MATERIALS AND METHODS.: Standard electron density phantom was used to establish CT to electron density calibrations curve. The CT to density curve for the CBCT images were observed for the period of six months. The kV CBCT scans used for adaptive planning was acquired with an on-board imager system mounted on a "Trilogy" linear accelerator. kV CBCT images were acquired for daily setup registration. The effect of variations in CT to density curve was studied on two clinical cases: prostate and lung.
  
  
  RESULTS
  The soft tissue contouring is superior in kV CBCT scans in comparison to mega voltage CT (MVCT) scans. The CT to density curve for the CBCT images was found steady over six months. Due to difficulty in attaining the reproducibility in daily setup for the prostate treatment, there is a day-to-day difference in dose to the rectum and bladder.
  
  
  CONCLUSIONS
  There is no need for generating a new CT to density curve for the adaptive planning on the kV CBCT images. Also, it is viable to perform the adaptive planning to check the dose to target and organ at risk (OAR) without performing a new kV CT scan, which will reduce the dose to the patient.
authors.affiliation: Department of Human Oncology, University of Wisconsin, Madison, WI, USA.
authors.forename: Poonam
authors.initials: P
authors.lastname: Yadav
authors.forename: Velayudham
authors.initials: V
authors.lastname: Ramasubramanian
authors.forename: Bhudatt R
authors.initials: BR
authors.lastname: Paliwal