title: Chemically functionalized water-soluble single-walled carbon nanotubes modulate morpho-functional characteristics of astrocytes.
abstract: We report the use of chemically functionalized water-soluble single-walled carbon nanotubes (ws-SWCNTs) for the modulation of morpho-functional characteristics of astrocytes. When added to the culturing medium, ws-SWCNTs were able to make astrocytes larger and stellate/mature, changes associated with the increase in glial fibrillary acidic protein immunoreactivity. Thus, ws-SWCNTs could have more beneficial effects at the injury site than previously thought; by affecting astrocytes, they could provide for a more comprehensive re-establishment of the brain computational power.
authors.affiliation: Department of Neurobiology, University of Alabama, Birmingham, Alabama 35294, United States.
authors.forename: Manoj K
authors.initials: MK
authors.lastname: Gottipati
authors.forename: Irina
authors.initials: I
authors.lastname: Kalinina
authors.forename: Elena
authors.initials: E
authors.lastname: Bekyarova
authors.forename: Robert C
authors.initials: RC
authors.lastname: Haddon
authors.forename: Vladimir
authors.initials: V
authors.lastname: Parpura
mesh_terms: D000818:Animals; D001253:Astrocytes / Q000166:cytology* / Q000187:drug effects / Q000502:physiology*; D049109:Cell Proliferation / Q000187:drug effects; D048429:Cell Size / Q000187:drug effects; D002478:Cells, Cultured; D051379:Mice; D037742:Nanotubes, Carbon / Q000737:chemistry*; D012995:Solubility; D014867:Water / Q000737:chemistry*
chemical_list: D037742:Nanotubes, Carbon; D014867:Water