title: [Local antibacterial therapy for the inflammatory diseases of the external and middle ear].
abstract: The objective of the present study was to estimate the efficacy and safety of candibioic designed for the treatment of the patients presenting with diffuse otitis externa and chronic otitis media. The open randomized trial included 40 patients with diffuse otitis externa and 40 ones with chronic otitis media who had undergone a surgical sanitation procedure. Their standard clinical and otorhinolaryngological examination was supplemented by the characteristic of clinical symptoms and personal complaints using the 10-score scale. The composite preparation candibiotic was found to be equally effective for the treatment of both diffuse otitis externa and chronic otitis media. The results of the study give reason to recommend the use of candibiotic as an efficacious and safe drug for the treatment of these conditions.
authors.forename: E M
authors.initials: EM
authors.lastname: Khon
authors.forename: G E
authors.initials: GE
authors.lastname: Dzhenzhera
authors.forename: A Iu
authors.initials: AIu
authors.lastname: Ovchinnikov
mesh_terms: D000287:Administration, Topical; D000328:Adult; D000900:Anti-Bacterial Agents / Q000008:administration & dosage; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage; D000935:Antifungal Agents / Q000008:administration & dosage; D001507:Beclomethasone / Q000008:administration & dosage*; D002701:Chloramphenicol / Q000008:administration & dosage*; D003022:Clotrimazole / Q000008:administration & dosage*; D004338:Drug Combinations; D005260:Female; D006801:Humans; D008297:Male; D010032:Otitis Externa / Q000209:etiology / Q000503:physiopathology / Q000628:therapy*; D010035:Otitis Media, Suppurative / Q000209:etiology / Q000503:physiopathology / Q000628:therapy*; D013506:Otologic Surgical Procedures / Q000379:methods; D019999:Pharmaceutical Solutions; D011182:Postoperative Care / Q000379:methods*; D016896:Treatment Outcome
chemical_list: D000900:Anti-Bacterial Agents; D000893:Anti-Inflammatory Agents; D000935:Antifungal Agents; D004338:Drug Combinations; D019999:Pharmaceutical Solutions; D002701:Chloramphenicol; D003022:Clotrimazole; D001507:Beclomethasone