title: Clinical efficacy of a serum integrating multiple cosmetic ingredients in the management of erythema of the face in aging skin.
abstract: BACKGROUND
  Skin redness is a common cosmetic concern affecting predominantly fair-skin individuals and often leading to rosacea. On the basis of the current scientific knowledge of the physiological mechanisms underlying the problem, a complex and integral skin care serum (100RXED2025) was developed and tested clinically for efficacy.
  
  
  METHODS
  Forty-five healthy men and women volunteers, age 30-65, were recruited. All subjects had fair skin (phototype I, II, or III) and presented some degree of skin redness with telangiectasia on the cheeks, the nose, or the nose sides, at baseline. In the course of this open label study, subjects applied the test product on their face, twice daily for 56 days. For each subject, skin redness was evaluated through colorimetric and visual analysis of photographs taken under cross-polarized light at T = 28 (week 4) and T = 56 (week 8), then compared to baseline measurements obtained at day 0.
  
  
  RESULTS
  Forty-four volunteers completed the study. On visual evaluation, skin redness had decreased in average by 32.2% at T = 28 (P < 0.001) and by 48.0% at T = 56 (P < 0.001). Importantly, 91% of the subjects showed improvement of skin redness at T = 28, reaching 100% at T = 56. Colorimetric analysis gave an average reduction in redness of 11.6% at T = 28 (P < 0.001) and 13.7% at T = 56 (P < 0.001).
  
  
  CONCLUSIONS
  The anti-redness efficacy of the test product was demonstrated after 28 days with further increase following 56 days of application.
authors.affiliation: Immanence Integral Dermo Correction, Quebec, Quebec, Canada.
authors.forename: Eric
authors.initials: E
authors.lastname: Dupont
authors.forename: Claude
authors.initials: C
authors.lastname: Léveillé
authors.forename: Juan
authors.initials: J
authors.lastname: Gomez
authors.forename: Manuel
authors.initials: M
authors.lastname: Loigeret
authors.forename: Estelle
authors.initials: E
authors.lastname: Loing
authors.forename: Diane
authors.initials: D
authors.lastname: Bilodeau
mesh_terms: D000279:Administration, Cutaneous; D000328:Adult; D000368:Aged; D003124:Colorimetry; D003358:Cosmetics / Q000627:therapeutic use*; D004890:Erythema / Q000188:drug therapy*; D005148:Facial Dermatoses / Q000188:drug therapy*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010781:Photography; D015595:Skin Aging; D018709:Statistics, Nonparametric; D013684:Telangiectasis / Q000188:drug therapy*
chemical_list: D003358:Cosmetics