title: Newly discovered angiogenesis inhibitors and their mechanisms of action.
abstract: In the past decade, the success of angiogenesis inhibitors in clinical contexts has established the antiangiogenic strategy as an important part of cancer therapy. During that time period, we have discovered and reported 17 compounds that exert potent inhibition on angiogenesis. These compounds exhibit tremendous diversity in their sources, structures, targets and mechanisms. These studies have generated new models for further modification and optimization of inhibitory compounds, new information for mechanistic studies and a new drug candidate for clinical development. In particular, through studies on the antiangiogenic mechanism of pseudolaric acid B, we discovered a novel mechanism by which the stability of hypoxia-inducible factor 1α is regulated by the transcription factor c-Jun. We also completed a preclinical study of AL3810, a compound with the potential to circumvent tumor drug resistance to a certain extent. All of these findings will be briefly reviewed in this article.
authors.affiliation: Division of Antitumor Pharmacology, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, China. zhmiao@mail.shcnc.ac.cn
authors.forename: Ze-hong
authors.initials: ZH
authors.lastname: Miao
authors.forename: Jian-ming
authors.initials: JM
authors.lastname: Feng
authors.forename: Jian
authors.initials: J
authors.lastname: Ding
mesh_terms: D020533:Angiogenesis Inhibitors / Q000494:pharmacology*; D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology*; D004224:Diterpenes / Q000494:pharmacology; D015195:Drug Design; D019008:Drug Resistance, Neoplasm; D006801:Humans; D009281:Naphthalenes / Q000494:pharmacology; D009369:Neoplasms / Q000098:blood supply / Q000188:drug therapy* / Q000473:pathology; D009389:Neovascularization, Pathologic / Q000188:drug therapy / Q000503:physiopathology; D011804:Quinolines / Q000494:pharmacology; D064750:Rabeprazole
chemical_list: D020533:Angiogenesis Inhibitors; D000970:Antineoplastic Agents; D004224:Diterpenes; D009281:Naphthalenes; D011804:Quinolines; D064750:Rabeprazole; C058391:pseudolaric acid B