title: Bisphosphonate therapy for painless fracture: change of HSAN 1 clinical course with biphosphonate and Vitamin D therapy.
abstract: Hereditary Sensory and Autonomic Neuropathies comprise a set of 5 rare neurologic conditions, little known to radiologists as the neurologic and skin abnormalities precede the radiographic changes by months or even years. We report a Caucasian patient with a clinical history of HSAN, most consistent with subtype 1, whose progressive, destructive bone changes of the foot were not only controlled but to a degree reversed by the administration of bisphosphonates (Alendronate ) and vitamin D (Colecalciferol). The authors believe that combined bisphosphonate and vitamin D therapy is the treatment of choice for progressive bony changes in HSAN1. This therapy may be beneficial in other neuropathic osteoarthropathies and possibly osteolytic bone disorders.
authors.affiliation: Ambulant Centre for Defects of Locomotor Apparatus, Prague, Czech Republic. ambul_centrum@volny.cz
authors.forename: I A
authors.initials: IA
authors.lastname: Marik
authors.forename: A
authors.initials: A
authors.lastname: Marikova
authors.forename: O
authors.initials: O
authors.lastname: Hudakova
authors.forename: M E
authors.initials: ME
authors.lastname: Samuels
authors.forename: K S
authors.initials: KS
authors.lastname: Kozlowski
mesh_terms: D019386:Alendronate / Q000627:therapeutic use*; D002762:Cholecalciferol / Q000627:therapeutic use*; D004164:Diphosphonates / Q000627:therapeutic use*; D005260:Female; D050723:Fractures, Bone / Q000188:drug therapy* / Q000209:etiology; D009477:Hereditary Sensory and Autonomic Neuropathies / Q000150:complications / Q000188:drug therapy* / Q000503:physiopathology; D006801:Humans; D014807:Vitamin D / Q000627:therapeutic use*
chemical_list: D004164:Diphosphonates; D014807:Vitamin D; D002762:Cholecalciferol; D019386:Alendronate