title: Bombyx mori transcription factors: genome-wide identification, expression profiles and response to pathogens by microarray analysis.
abstract: Transcription factors are present in all living organisms, and play vital roles in a wide range of biological processes. Studies of transcription factors will help reveal the complex regulation mechanism of organisms. So far, hundreds of domains have been identified that show transcription factor activity. Here, 281 reported transcription factor domains were used as seeds to search the transcription factors in genomes of Bombyx mori L. (Lepidoptera: Bombycidae) and four other model insects. Overall, 666 transcription factors including 36 basal factors and 630 other factors were identified in B. mori genome, which accounted for 4.56% of its genome. The silkworm transcription factors' expression profiles were investigated in relation to multiple tissues, developmental stages, sexual dimorphism, and responses to oral infection by pathogens and direct bacterial injection. These all provided rich clues for revealing the transcriptional regulation mechanism of silkworm organ differentiation, growth and development, sexual dimorphism, and response to pathogen infection.
authors.affiliation: State Key Laboratory of Silkworm Genome Biology, Southwest University, Chongqing 400716, China. huangluling@yeah.net
authors.forename: Lulin
authors.initials: L
authors.lastname: Huang
authors.forename: Tingcai
authors.initials: T
authors.lastname: Cheng
authors.forename: Pingzhen
authors.initials: P
authors.lastname: Xu
authors.forename: Ting
authors.initials: T
authors.lastname: Fang
authors.forename: Qingyou
authors.initials: Q
authors.lastname: Xia
mesh_terms: D000284:Administration, Oral; D000818:Animals; D000852:Anopheles / Q000235:genetics; D001407:Bacillus / Q000276:immunology; D052982:Beauveria / Q000276:immunology; D001516:Bees / Q000235:genetics; D012831:Bombyx / Q000235:genetics* / Q000254:growth & development / Q000276:immunology* / Q000382:microbiology; D004331:Drosophila melanogaster / Q000235:genetics; D004926:Escherichia coli / Q000276:immunology; D005260:Female; D018507:Gene Expression Regulation, Developmental; D017344:Genes, Insect; D055106:Genome-Wide Association Study; D007814:Larva / Q000235:genetics / Q000254:growth & development / Q000276:immunology / Q000382:microbiology; D008297:Male; D046228:Microarray Analysis; D017924:Nucleopolyhedroviruses / Q000276:immunology; D009928:Organ Specificity; D010802:Phylogeny; D011679:Pupa / Q000235:genetics / Q000254:growth & development; D012333:RNA, Messenger / Q000378:metabolism; D017678:Sex Distribution; D014157:Transcription Factors / Q000235:genetics*; D014231:Tribolium / Q000235:genetics
chemical_list: D012333:RNA, Messenger; D014157:Transcription Factors