title: Predicting coupling specificity of GPCRs based on the optimization of the coupling regions.
abstract: Prediction of promiscuous coupling between G-protein coupling receptors (GPCRs) and various G-proteins is one of the challenges for current research. In this article, a novel method that based on the optimization of the coupling regions is proposed. The cross validation results demonstrate that it can achieve an average accuracy of over 80% for promiscuous coupling prediction. The results further suggest that the optimized coupling regions may be important for the processes of signal transduction pathways.
authors.affiliation: Department of Computer Science & Technology, East China Normal University, Shanghai, China.
authors.forename: Ran
authors.initials: R
authors.lastname: Tao
authors.forename: Zhenran
authors.initials: Z
authors.lastname: Jiang
authors.forename: Weiming
authors.initials: W
authors.lastname: Yu
authors.forename: Junxiang
authors.initials: J
authors.lastname: Wang
mesh_terms: D020962:Heterotrimeric GTP-Binding Proteins / Q000378:metabolism*; D043562:Receptors, G-Protein-Coupled / Q000378:metabolism*; D015203:Reproducibility of Results; D013379:Substrate Specificity; D060388:Support Vector Machine
chemical_list: D043562:Receptors, G-Protein-Coupled; D020962:Heterotrimeric GTP-Binding Proteins