title: Secondary acute myelogenous leukemia (AML) with trisomy 10 and del(9q) following precursor B-cell acute lymphoblastic leukemia (ALL) with a hyperdiploid karyotype.
abstract: Acute myelogenous leukemia (AML) secondary to acute lymphoblastic leukemia (ALL) in children is uncommon and usually occurs within 10 years of completing therapy for ALL. A variety of recurrent cytogenetic abnormalities have been described, suggesting significant biological heterogeneity. We report a case of highly refractory secondary AML with trisomy 10 and del(9q) occurring in an adolescent female 12 years after she was treated successfully for precursor B-cell ALL with chemotherapy only.
authors.affiliation: Department of Pediatric Hematology/Oncology, NBK Children's Hospital, Shuwaikh, Alkuwait, Kuwait.
authors.forename: Karima
authors.initials: K
authors.lastname: Al-Tahou
authors.forename: Samir
authors.initials: S
authors.lastname: Jamil
authors.forename: Rajen
authors.initials: R
authors.lastname: Mody
authors.forename: Amy
authors.initials: A
authors.lastname: Knaus
authors.forename: Mark
authors.initials: M
authors.lastname: Micale
authors.forename: James
authors.initials: J
authors.lastname: Huang
mesh_terms: D000293:Adolescent; D002675:Child, Preschool; D002869:Chromosome Aberrations; D002871:Chromosome Banding; D002872:Chromosome Deletion; D002879:Chromosomes, Human, Pair 10; D002899:Chromosomes, Human, Pair 9; D003582:Cytogenetics; D004171:Diploidy; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D007621:Karyotyping; D015456:Leukemia, Biphenotypic, Acute / Q000235:genetics* / Q000473:pathology; D015470:Leukemia, Myeloid, Acute / Q000150:complications / Q000235:genetics*; D008677:Metaphase; D014314:Trisomy