title: CADLIVE optimizer: web-based parameter estimation for dynamic models.
abstract: Computer simulation has been an important technique to capture the dynamics of biochemical networks. In most networks, however, few kinetic parameters have been measured in vivo because of experimental complexity. We develop a kinetic parameter estimation system, named the CADLIVE Optimizer, which comprises genetic algorithms-based solvers with a graphical user interface. This optimizer is integrated into the CADLIVE Dynamic Simulator to attain efficient simulation for dynamic models.
authors.affiliation: Department of Bioscience and Bioinformatics, Kyushu Institute of Technology, Iizuka, Fukuoka, 820-8502, Japan. kurata@bio.kyutech.ac.jp.
authors.forename: Kentaro
authors.initials: K
authors.lastname: Inoue
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Maeda
authors.forename: Yuki
authors.initials: Y
authors.lastname: Kato
authors.forename: Shinpei
authors.initials: S
authors.lastname: Tonami
authors.forename: Shogo
authors.initials: S
authors.lastname: Takagi
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Kurata