title: [The relationship between carboxylesterase 1 gene polymorphisms and susceptibility to antituberculosis drug-induced hepatotoxicity].
abstract: OBJECTIVE
  To study the relationship between the genetic polymorphisms of carboxylesterase 1 gene (CES1) and the susceptibility to antituberculosis drug-induced hepatotoxicity (ATBDIH).
  
  
  METHODS
  Genetic polymorphisms of CES1 in 473 tuberculosis patients with or without hepatotoxicity (200:273) after antituberculosis chemotherapy were analyzed by PCR-MassArray.
  
  
  RESULTS
  In 4 tags of CES1 single nucleotide polymorphism (SNP), the frequency of the rs1968753 allele had statistical difference between the hepatotoxicity group and the no-hepatotoxicity group(P = 0.0236). The characteristics of anti-hepatotoxicity had been shown relationship with rs8192950 (P = 0.044, OR = 0.649, 95%CI = 0.426 - 0.989, AC/AA) and rs1968753 (P = 0.048, OR = 0.556, 95%CI = 0.311 - 0.995, GG/AA). The diplotypes with 'CGC' haplotype exhibited significant protection against hepatotoxicity at one copy (P = 0.048, OR = 0.654, 95%CI = 0.430 - 0.996).
  
  
  CONCLUSIONS
  The genetic polymorphisms of CES1 might have significant association with ATBDIH. SNP rs8192950 AC genotype and rs1968753 GG genotype might be the candidates for risk prediction of ATBDIH.
authors.affiliation: Institute of Tuberculosis Research, the 309th Hospital of Chinese PLA, Beijing, China. wu-xueqiong@263.net
authors.forename: Xue-qiong
authors.initials: XQ
authors.lastname: Wu
authors.forename: Dong-lin
authors.initials: DL
authors.lastname: Zhu
authors.forename: Jun-xian
authors.initials: JX
authors.lastname: Zhang
authors.forename: Yu
authors.initials: Y
authors.lastname: Zhong
authors.forename: Yun
authors.initials: Y
authors.lastname: Xi
authors.forename: Hui-ru
authors.initials: HR
authors.lastname: An
authors.forename: Yan
authors.initials: Y
authors.lastname: Liang
authors.forename: You-rong
authors.initials: YR
authors.lastname: Yang
mesh_terms: D000328:Adult; D000995:Antitubercular Agents / Q000633:toxicity*; D002265:Carboxylic Ester Hydrolases / Q000235:genetics*; D056486:Chemical and Drug Induced Liver Injury / Q000453:epidemiology / Q000235:genetics*; D005260:Female; D005838:Genotype; D006801:Humans; D008099:Liver / Q000187:drug effects* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D012189:Retrospective Studies; D014376:Tuberculosis / Q000188:drug therapy* / Q000473:pathology; D055815:Young Adult
chemical_list: D000995:Antitubercular Agents; D002265:Carboxylic Ester Hydrolases; C474609:CES1 protein, human