title: A new sesquiterpene lactone from Sarcandra glabra.
abstract: A new eudesmanolide sesquiterpene, atractylenolide IV (1), together with seven known compounds were isolated from the 70% aqueous acetonic extract of the whole plant of Sarcandra glabra (Chloranthaceae). Their structures were established by spectral analysis, mainly UV, IR, HRESI-MS, 1D and 2D-NMR experiments (HSQC, HMBC and NOESY). Compounds 1-4 showed no remarkable cytotoxic activity against Hela, HCT-8 and MCF-7 cancer cell lines with IC50 > 50 µg mL(-1).
authors.affiliation: Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100193, China.
authors.forename: Xiao-Ru
authors.initials: XR
authors.lastname: Hu
authors.forename: Hai-Feng
authors.initials: HF
authors.lastname: Wu
authors.forename: Xiao-Po
authors.initials: XP
authors.lastname: Zhang
authors.forename: Jun-Shan
authors.initials: JS
authors.lastname: Yang
authors.forename: Zhong
authors.initials: Z
authors.lastname: Dai
authors.forename: Rui-Chao
authors.initials: RC
authors.lastname: Lin
authors.forename: Xu-Dong
authors.initials: XD
authors.lastname: Xu
mesh_terms: D007783:Lactones / Q000737:chemistry*; D019684:Magnoliopsida / Q000737:chemistry*; D012717:Sesquiterpenes / Q000737:chemistry*
chemical_list: D007783:Lactones; D012717:Sesquiterpenes; C586015:atractylenolide IV