title: [Clinical analysis of cytomegalovirus infection after allogeneic hematopoietic stem cell transplantation].
abstract: The objective of this study was to explore the incidence and therapeutic efficacy of cytomegalovirus (CMV) infection after allogeneic hematopoietic stem cell transplantation (allo-HSCT). The clinical data of 140 patients undergoing allo-HSCT in our department of hematology from 2010-01 to 2012-01 were retrospectively analyzed. The results showed that the incidence of CMV infection was 4.3% (48/140), the time for the first detection of positive CMV-DNA was at day 45 (33 to 68) after allo-HSCT, and the CMV quantitative range was 1.25×10(3) - 5.5×10(6). There were 2 cases of CMV-related interstitial pneumonia and 5 cases of hemorrhagic bladder inflammation. A total of 65 patients suffered from graft versus host disease (GVHD), in which 32 cases (49.2%) were accompanied with CMV infection, CMV-DNA negative in patients treated with ganciclovir, foscarnet sodium anti-CMV was at day 45 (33 to 68) with the effective rate of 100%. 12 patients with CMV infection were accompanied with transient neutropenia and thrombocytopenia. It is concluded that after allo-HSCT the CMV infection occurs frequently. The patients with GVHD have a higher incidence of CMV infection. Ganciclovir and foscarnet sodium are reliable to be used for treatment of CMV infection with fewer adverse reactions.
authors.affiliation: Department of Hematology, Beijing Military Area General Hospital, Beijing, China.
authors.forename: Zhi
authors.initials: Z
authors.lastname: Guo
authors.forename: Hui-Ren
authors.initials: HR
authors.lastname: Chen
authors.forename: Xiao-Dong
authors.initials: XD
authors.lastname: Liu
authors.forename: Jia-Ming
authors.initials: JM
authors.lastname: Bian
authors.forename: Xue-Peng
authors.initials: XP
authors.lastname: He
authors.forename: Jin-Xing
authors.initials: JX
authors.lastname: Lou
authors.forename: Peng
authors.initials: P
authors.lastname: Chen
authors.forename: Kai
authors.initials: K
authors.lastname: Yang
authors.forename: Dan
authors.initials: D
authors.lastname: Liu
authors.forename: Yuan
authors.initials: Y
authors.lastname: Zhang
mesh_terms: D000293:Adolescent; D000328:Adult; D002648:Child; D002675:Child, Preschool; D003586:Cytomegalovirus Infections / Q000188:drug therapy / Q000209:etiology*; D005260:Female; D017245:Foscarnet / Q000627:therapeutic use; D015774:Ganciclovir / Q000627:therapeutic use; D006086:Graft vs Host Disease; D018380:Hematopoietic Stem Cell Transplantation / Q000009:adverse effects*; D006801:Humans; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D012307:Risk Factors; D014184:Transplantation, Homologous; D055815:Young Adult
chemical_list: D017245:Foscarnet; D015774:Ganciclovir