title: Tacrolimus on Kimura's disease: a case report.
abstract: OBJECTIVE
  We report preliminary results of an ongoing study that assesses the efficacy of tacrolimus on Kimura's disease (KD).
  
  
  METHODS
  A patient with refractory KD after surgery and treatment with prednisone was treated with tacrolimus. Tacrolimus (FK-506) was administered at an initial dosage of 1 mg every 12 hours, and FK-506 concentration in the blood was monitored monthly. FK-506 blood concentration was controlled within 5 to 15 μg/L. After 6 months, the dosage of tacrolimus was reduced to 0.5 mg daily for another 2 months and then treatment was stopped.
  
  
  RESULTS
  Swelling of the bilateral salivary glands disappeared within the first week. No serious side effects were noted and the disease has not recurred in the 2 years of follow-up.
  
  
  CONCLUSIONS
  Tacrolimus may be an effective treatment for patients with KD, but more research is needed to determine its long-term efficacy and safety as well as its mechanism of action.
authors.affiliation: Oral and Maxillofacial Surgery Department of the First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.
authors.forename: Shu
authors.initials: S
authors.lastname: Da-Long
authors.affiliation: Oral and Maxillofacial Surgery Department of the First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China. Electronic address: shuxindaddy@sohu.com.
authors.forename: Ran
authors.initials: R
authors.lastname: Wei
authors.affiliation: Oral and Maxillofacial Surgery Department of the First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.
authors.forename: Guo
authors.initials: G
authors.lastname: Bing
authors.affiliation: Oral and Maxillofacial Surgery Department of the First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.
authors.forename: Zhang
authors.initials: Z
authors.lastname: Yun-Yan
authors.affiliation: Oral and Maxillofacial Surgery Department of the First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.
authors.forename: Liu
authors.initials: L
authors.lastname: Xiang-Zhen
authors.affiliation: Oral and Maxillofacial Surgery Department of the First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.
authors.forename: Liao
authors.initials: L
authors.lastname: Xin
mesh_terms: D000328:Adult; D000796:Angiolymphoid Hyperplasia with Eosinophilia / Q000175:diagnosis / Q000188:drug therapy* / Q000601:surgery; D003131:Combined Modality Therapy; D005938:Glucocorticoids / Q000627:therapeutic use; D006801:Humans; D007166:Immunosuppressive Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D008279:Magnetic Resonance Imaging; D008297:Male; D011241:Prednisone / Q000627:therapeutic use; D016559:Tacrolimus / Q000008:administration & dosage / Q000627:therapeutic use*
chemical_list: D005938:Glucocorticoids; D007166:Immunosuppressive Agents; D011241:Prednisone; D016559:Tacrolimus