title: PEGylated PRINT nanoparticles: the impact of PEG density on protein binding, macrophage association, biodistribution, and pharmacokinetics.
abstract: In this account, we varied PEGylation density on the surface of hydrogel PRINT nanoparticles and systematically observed the effects on protein adsorption, macrophage uptake, and circulation time. Interestingly, the density of PEGylation necessary to promote a long-circulating particle was dramatically less than what has been previously reported. Overall, our methodology provides a rapid screening technique to predict particle behavior in vivo and our results deliver further insight to what PEG density is necessary to facilitate long-circulation.
authors.affiliation: Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, North Carolina 27599, USA.
authors.forename: Jillian L
authors.initials: JL
authors.lastname: Perry
authors.forename: Kevin G
authors.initials: KG
authors.lastname: Reuter
authors.forename: Marc P
authors.initials: MP
authors.lastname: Kai
authors.forename: Kevin P
authors.initials: KP
authors.lastname: Herlihy
authors.forename: Stephen W
authors.initials: SW
authors.lastname: Jones
authors.forename: J Chris
authors.initials: JC
authors.lastname: Luft
authors.forename: Mary
authors.initials: M
authors.lastname: Napier
authors.forename: James E
authors.initials: JE
authors.lastname: Bear
authors.forename: Joseph M
authors.initials: JM
authors.lastname: DeSimone
mesh_terms: D000327:Adsorption; D000818:Animals; D005260:Female; D020100:Hydrogels; D008264:Macrophages / Q000502:physiology; D051379:Mice; D008807:Mice, Inbred BALB C; D008968:Molecular Conformation; D053758:Nanoparticles / Q000008:administration & dosage / Q000737:chemistry*; D036103:Nanotechnology; D010587:Phagocytosis; D011092:Polyethylene Glycols / Q000737:chemistry* / Q000493:pharmacokinetics; D011485:Protein Binding; D013499:Surface Properties; D014018:Tissue Distribution
chemical_list: D020100:Hydrogels; D011092:Polyethylene Glycols