title: Expression of RANTES, eotaxin-2, ICAM-1, LFA-1 and CCR-3 in chronic rhinosinusitis patients with nasal polyposis.
abstract: OBJECTIVE
  To compare gene expression of the chemokines RANTES and eotaxin-2, its receptor, CCR-3, adhesion molecule ICAM-1 and its receptor LFA-1 in eosinophilic polyps and in control normal nasal mucosa.
  
  
  METHODS
  Gene expression was quantified by Real Time PCR in polyps (n=35) and in healthy nasal mucosa (n=15).
  
  
  RESULTS
  Eosinophilic polyps showed a higher expression of eotaxin-2 and RANTES, but not of CCR-3, ICAM-1 or LFA-1 compared to control nasal mucosa.
  
  
  CONCLUSIONS
  Eosinophilic polyps present greater expression of eotaxin-2 and RANTES, but not of CCR-3, ICAM-1 or LFA-1 compared to control nasal mucosa.
authors.affiliation: Department of Ophtalmology, Otorhinolaryngology and Head and Neck Surgery, Faculty of Medicine of Ribeirao Preto, USP, Sao Paulo-SP, Brazil.
authors.forename: Fransérgio Emílio
authors.initials: FE
authors.lastname: Cavallari
authors.forename: Fabiana Cardoso Pereira
authors.initials: FC
authors.lastname: Valera
authors.forename: Aline Jorge
authors.initials: AJ
authors.lastname: Gallego
authors.forename: Rafael Rossell
authors.initials: RR
authors.lastname: Malinsky
authors.forename: Daniel Salgado
authors.initials: DS
authors.lastname: Küpper
authors.forename: Cristiane
authors.initials: C
authors.lastname: Milanezi
authors.forename: João Santana da
authors.initials: JS
authors.lastname: Silva
authors.forename: Edwin
authors.initials: E
authors.lastname: Tamashiro
authors.forename: Wilma Terezinha
authors.initials: WT
authors.lastname: Anselmo-Lima
mesh_terms: D016022:Case-Control Studies; D054423:Chemokine CCL24 / Q000235:genetics / Q000378:metabolism; D018946:Chemokine CCL5 / Q000235:genetics / Q000378:metabolism; D002908:Chronic Disease; D015870:Gene Expression; D006801:Humans; D018799:Intercellular Adhesion Molecule-1 / Q000235:genetics / Q000378:metabolism; D016169:Lymphocyte Function-Associated Antigen-1 / Q000235:genetics / Q000378:metabolism; D009297:Nasal Mucosa; D009298:Nasal Polyps / Q000150:complications / Q000378:metabolism*; D016133:Polymerase Chain Reaction; D054397:Receptors, CCR3 / Q000235:genetics / Q000378:metabolism; D012220:Rhinitis / Q000150:complications / Q000378:metabolism*; D012852:Sinusitis / Q000150:complications / Q000378:metabolism*
chemical_list: D054423:Chemokine CCL24; D018946:Chemokine CCL5; D016169:Lymphocyte Function-Associated Antigen-1; D054397:Receptors, CCR3; D018799:Intercellular Adhesion Molecule-1