title: Preparation and characterization of antimicrobial wound dressings based on silver, gellan, PVA and borax.
abstract: Silver-loaded dressings are designed to provide the same antimicrobial activity of topical silver, with the advantages of a sustained silver release and a reduced number of dressing changes. Moreover, such type of dressing must provide a moist environment, avoiding fiber shedding, dehydration and adherence to the wound site. Here we describe the preparation of a novel silver-loaded dressing based on a Gellan/Hyaff(®) (Ge-H) non woven, treated with a polyvinyl alcohol (PVA)/borax system capable to enhance the entrapment of silver in the dressing and to modulate its release. The new hydrophilic non woven dressings show enhanced water uptake capability and slow dehydration rates. A sustained silver release is also achieved. The antibacterial activity was confirmed on Staphylococcus aureus and Pseudomonas aeruginosa.
authors.affiliation: Department of Drug Chemistry and Technologies, Sapienza University of Rome, Piazzale Aldo Moro 5, 00185 Rome, Italy.
authors.forename: C
authors.initials: C
authors.lastname: Cencetti
authors.forename: D
authors.initials: D
authors.lastname: Bellini
authors.forename: A
authors.initials: A
authors.lastname: Pavesio
authors.forename: D
authors.initials: D
authors.lastname: Senigaglia
authors.forename: C
authors.initials: C
authors.lastname: Passariello
authors.forename: A
authors.initials: A
authors.lastname: Virga
authors.forename: P
authors.initials: P
authors.lastname: Matricardi
mesh_terms: D000890:Anti-Infective Agents / Q000737:chemistry* / Q000494:pharmacology; D001458:Bandages; D001881:Borates / Q000737:chemistry* / Q000494:pharmacology; D011135:Polysaccharides, Bacterial / Q000737:chemistry* / Q000494:pharmacology; D011142:Polyvinyl Alcohol / Q000737:chemistry* / Q000494:pharmacology; D012834:Silver / Q000737:chemistry* / Q000494:pharmacology; D013211:Staphylococcus aureus / Q000254:growth & development; D014945:Wound Healing / Q000187:drug effects; D014947:Wounds and Injuries / Q000628:therapy
chemical_list: D000890:Anti-Infective Agents; D001881:Borates; D011135:Polysaccharides, Bacterial; C018851:borax; D012834:Silver; C048288:gellan gum; D011142:Polyvinyl Alcohol