title: Gold nanoparticles grown on ionic liquid-functionalized single-walled carbon nanotubes: new materials for photothermal therapy.
abstract: Gold nanoparticles were grown on single-walled carbon nanotubes (SWNTs) coated with a thiol-functionalized ionic liquid resulting in the formation of core-shell structures referred to as SWNT-IL-Au nanohybrid materials. The nanohybrid materials were characterized by high-resolution transmission electron microscopy (HR-TEM), Raman-, and UV/Vis absorption spectroscopy. The nanohybrid materials were found to enter lysosomes in HeLa cells and show negligible cytotoxicity. Interestingly, they have an enhanced NIR absorption that is effectively transferred into heat to cause localized hyperthermia, resulting in rapid cell death; overall, the material appears to have excellent properties for photothermal therapeutic applications.
authors.affiliation: School of Chemistry and Chemical Technology, Shanghai Jiao Tong University, Shanghai, 200240, P.R. China.
authors.forename: Lingjie
authors.initials: L
authors.lastname: Meng
authors.forename: Lvye
authors.initials: L
authors.lastname: Niu
authors.forename: Ling
authors.initials: L
authors.lastname: Li
authors.forename: Qinghua
authors.initials: Q
authors.lastname: Lu
authors.forename: Zhaofu
authors.initials: Z
authors.lastname: Fei
authors.forename: Paul J
authors.initials: PJ
authors.lastname: Dyson
mesh_terms: D017209:Apoptosis / Q000187:drug effects / Q000528:radiation effects; D001672:Biocompatible Materials / Q000737:chemistry / Q000633:toxicity; D006046:Gold / Q000737:chemistry*; D006367:HeLa Cells; D006801:Humans; D006979:Hyperthermia, Induced; D007259:Infrared Rays; D052578:Ionic Liquids / Q000737:chemistry*; D008247:Lysosomes / Q000378:metabolism; D053768:Metal Nanoparticles / Q000737:chemistry*; D008856:Microscopy, Fluorescence; D037742:Nanotubes, Carbon / Q000737:chemistry* / Q000633:toxicity / Q000648:ultrastructure; D013696:Temperature
chemical_list: D001672:Biocompatible Materials; D052578:Ionic Liquids; D037742:Nanotubes, Carbon; D006046:Gold