title: Concurrent Paget's disease and basal cell carcinoma of the vulva; a case report.
abstract: An 82-year-old Caucasian woman had a long-standing history of recurrent Paget's disease of the right perianal region that was documented by multiple skin biopsies. Histological examination of a skin biopsy from an erythematous raised right perianal area revealed large rounded cells with ample pale staining cytoplasm scattered throughout the epidermis in multifocal nests and a flattened basal layer. A second lesion showed tongues of basaloid cells with peripheral palisading in continuity with the undersurface of the epidermis at multiple points. The individual tumor nests had cytoplasmic melanization and slit-like stromal separation. The tumor cells in the epidermis showed positive immunoreactivity for carcinoembryonic antigen while the basaloid cells were negative. A diagnosis of combined vulvar Paget's disease and basal cell carcinoma of an infundibulocystic type was rendered. Concurrent involvement of the same area by Paget's disease and Basal cell carcinoma (BCC) has been reported only once. Here we report a second case of BCC concurrent with vulvar Paget's disease.
authors.affiliation: Department of Anatomic Pathology, H. Lee Moffitt Cancer Center & Research Institute, 12902 Magnolia Drive, Tampa, FL 33625, USA.
authors.forename: Maisoun
authors.initials: M
authors.lastname: Abdelbaqi
authors.forename: Rodney E
authors.initials: RE
authors.lastname: Shackelford
authors.forename: Brian C
authors.initials: BC
authors.lastname: Quigley
authors.forename: Ardeshir
authors.initials: A
authors.lastname: Hakam
mesh_terms: D000369:Aged, 80 and over; D002280:Basal Cell Carcinoma / Q000150:complications / Q000473:pathology* / Q000601:surgery; D005260:Female; D006801:Humans; D009378:Neoplasms, Multiple Primary; D010145:Paget Disease, Extramammary / Q000150:complications / Q000473:pathology* / Q000601:surgery; D014846:Vulvar Neoplasms / Q000150:complications / Q000473:pathology* / Q000601:surgery