title: Quinones derived from plant secondary metabolites as anti-cancer agents.
abstract: Quinones are plant-derived secondary metabolites that present some anti-proliferation and anti-metastasis effects in various cancer types both in vitro and in vivo. This review focuses on the anti-cancer prospects of plant-derived quinones, namely, aloe-emodin, juglone, β-lapachol, plumbagin, shikonin, and thymoquinone. We intend to summarize their anti-cancer effects and investigate the mechanism of actions to promote the research and development of anti-cancer agents from quinones.
authors.affiliation: State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macao, China.
authors.forename: Jin-Jian
authors.initials: JJ
authors.lastname: Lu
authors.forename: Jiao-Lin
authors.initials: JL
authors.lastname: Bao
authors.forename: Guo-Sheng
authors.initials: GS
authors.lastname: Wu
authors.forename: Wen-Shan
authors.initials: WS
authors.lastname: Xu
authors.forename: Ming-Qing
authors.initials: MQ
authors.lastname: Huang
authors.forename: Xiu-Ping
authors.initials: XP
authors.lastname: Chen
authors.forename: Yi-Tao
authors.initials: YT
authors.lastname: Wang
mesh_terms: D000880:Anthraquinones / Q000302:isolation & purification / Q000494:pharmacology; D000972:Antineoplastic Agents, Phytogenic / Q000302:isolation & purification* / Q000494:pharmacology; D016227:Benzoquinones / Q000302:isolation & purification / Q000494:pharmacology; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D006801:Humans; D009285:Naphthoquinones / Q000302:isolation & purification / Q000494:pharmacology; D009369:Neoplasms / Q000188:drug therapy; D010936:Plant Extracts / Q000737:chemistry*
chemical_list: D000880:Anthraquinones; D000972:Antineoplastic Agents, Phytogenic; D016227:Benzoquinones; D009285:Naphthoquinones; D010936:Plant Extracts; C016101:shikonin; C008252:lapachol; C518327:aloe emodin; C003466:thymoquinone; C005134:juglone; C014758:plumbagin