title: Synthesis and structure of two new mycolactones isolated from M. ulcerans subsp. shinshuense.
abstract: Two new mycolactones, mycolactones S1 and S2, were isolated from culture agar of Mycobacterium ulcerans subsp. shinshuense. Their structures were established in a three-step procedure: (1) probable structures were speculated from MS analysis; (2) candidates were synthesized; (3) HPLC profiles were established for identification of the natural products. Newly isolated mycolactones correspond to the "oxidized forms" of mycolactone A/B, the causative toxin of Buruli ulcer, isolated from Mycobacterium ulcerans.
authors.affiliation: Department of Chemistry and Chemical Biology, Harvard University, 12 Oxford Street, Cambridge, Massachusetts 02138, USA.
authors.forename: Sudhir M
authors.initials: SM
authors.lastname: Hande
authors.forename: Yuko
authors.initials: Y
authors.lastname: Kazumi
authors.forename: W George
authors.initials: WG
authors.lastname: Lai
authors.forename: Katrina L
authors.initials: KL
authors.lastname: Jackson
authors.forename: Shinji
authors.initials: S
authors.lastname: Maeda
authors.forename: Yoshito
authors.initials: Y
authors.lastname: Kishi
mesh_terms: D054312:Buruli Ulcer / Q000209:etiology; D002851:Chromatography, High Pressure Liquid; D018942:Macrolides / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D019911:Mycobacterium ulcerans / Q000737:chemistry*
chemical_list: D018942:Macrolides; C579145:mycolactone S1; C579146:mycolactone S2