title: Volatile general anesthetic sensing with organic field-effect transistors integrating phospholipid membranes.
abstract: The detailed action mechanism of volatile general anesthetics is still unknown despite their effect has been clinically exploited for more than a century. Long ago it was also assessed that the potency of an anesthetic molecule well correlates with its lipophilicity and phospholipids were eventually identified as mediators. As yet, the direct effect of volatile anesthetics at physiological relevant concentrations on membranes is still under scrutiny. Organic field-effect transistors (OFETs) integrating a phospholipid (PL) functional bio inter-layer (FBI) are here proposed for the electronic detection of archetypal volatile anesthetic molecules such as diethyl ether and halothane. This technology allows to directly interface a PL layer to an electronic transistor channel, and directly probe subtle changes occurring in the bio-layer. Repeatable responses of PL FBI-OFET to anesthetics are produced in a concentration range that reaches few percent, namely the clinically relevant regime. The PL FBI-OFET is also shown to deliver a comparably weaker response to a non-anesthetic volatile molecule such as acetone.
authors.affiliation: Dipartimento di Chimica, Università degli Studi di Bari Aldo Moro, 70126 Bari, Italy. angione@chimica.uniba.it
authors.forename: Maria
authors.initials: M
authors.lastname: Daniela Angione
authors.forename: Maria
authors.initials: M
authors.lastname: Magliulo
authors.forename: Serafina
authors.initials: S
authors.lastname: Cotrone
authors.forename: Antonia
authors.initials: A
authors.lastname: Mallardi
authors.forename: Davide
authors.initials: D
authors.lastname: Altamura
authors.forename: Cinzia
authors.initials: C
authors.lastname: Giannini
authors.forename: Nicola
authors.initials: N
authors.lastname: Cioffi
authors.forename: Luigia
authors.initials: L
authors.lastname: Sabbatini
authors.forename: Danka
authors.initials: D
authors.lastname: Gobeljic
authors.forename: Gaetano
authors.initials: G
authors.lastname: Scamarcio
authors.forename: Gerardo
authors.initials: G
authors.lastname: Palazzo
authors.forename: Luisa
authors.initials: L
authors.lastname: Torsi
mesh_terms: D018681:Anesthetics, General / Q000032:analysis*; D015374:Biosensing Techniques / Q000295:instrumentation*; D003217:Conductometry / Q000295:instrumentation*; D004867:Equipment Design; D019544:Equipment Failure Analysis; D008567:Membranes, Artificial; D009930:Organic Chemicals / Q000737:chemistry; D010743:Phospholipids / Q000737:chemistry*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D018511:Systems Integration; D014173:Transistors, Electronic; D055549:Volatile Organic Compounds / Q000032:analysis*
chemical_list: D018681:Anesthetics, General; D008567:Membranes, Artificial; D009930:Organic Chemicals; D010743:Phospholipids; D055549:Volatile Organic Compounds