title: [Local therapy of acute sensorinerual deafness by means of intratympanic administration of steroids].
abstract: OBJECTIVE
  to estimate the efficacy of local therapy of acute sensorinerual deafness by means of intratympanic administration of steroids.
  
  
  METHODS
  the study included 73 patients presenting with acute sensorinerual deafness (ACND). 24 of them were given local steroid therapy (through a shunt) during 6 months, another 24 patients received traditional systemic therapy, and 25 ones systemic steroid monotherapy (intravenously) for 10 days. The tonal threshold audiograms obtained before as well as 1, 3, and 6 months after the treatment were compared. It was shown that the efficacy of the intratympanic administration of steroids during 1 month was not significantly different from that of systemic therapy. The long-term therapy (for 6 months) by the intratympanic administration of steroids yielded better results than systemic therapy.
  
  
  CONCLUSIONS
  the local intratympanic administration of steroids may be used as a self-contained method for the primary treatment of acute sensorinerual deafness.
authors.forename: S Ia
authors.initials: SIa
authors.lastname: Kosiakov
authors.forename: A G
authors.initials: AG
authors.lastname: Atanesian
authors.forename: A V
authors.initials: AV
authors.lastname: Gunenkov
mesh_terms: D000208:Acute Disease; D000287:Administration, Topical; D000328:Adult; D001299:Audiometry / Q000379:methods*; D057186:Comparative Effectiveness Research; D003907:Dexamethasone / Q000008:administration & dosage*; D004432:Ear, Middle / Q000187:drug effects / Q000503:physiopathology; D005260:Female; D005938:Glucocorticoids / Q000008:administration & dosage; D006319:Hearing Loss, Sensorineural / Q000150:complications / Q000175:diagnosis* / Q000503:physiopathology / Q000628:therapy*; D006801:Humans; D007275:Injections, Intravenous; D008297:Male; D008875:Middle Aged; D008876:Middle Ear Ventilation / Q000379:methods*; D016896:Treatment Outcome
chemical_list: D005938:Glucocorticoids; D003907:Dexamethasone