title: Total synthesis of (+)-aureol.
abstract: A total synthesis of the marine sponge meroterpenoid (+)-aureol has been achieved in 12 steps (6% overall yield) from (+)-sclareolide. Key steps of the synthesis include a biosynthetically inspired sequence of 1,2-hydride and methyl shifts, and a biomimetic cycloetherification reaction.
authors.affiliation: School of Chemistry & Physics, University of Adelaide, North Terrace, Adelaide SA 5005, Australia.
authors.forename: Kevin K W
authors.initials: KK
authors.lastname: Kuan
authors.forename: Henry P
authors.initials: HP
authors.lastname: Pepper
authors.forename: Witold M
authors.initials: WM
authors.lastname: Bloch
authors.forename: Jonathan H
authors.initials: JH
authors.lastname: George
mesh_terms: D000818:Animals; D004224:Diterpenes / Q000737:chemistry*; D008386:Marine Biology; D015394:Molecular Structure; D011161:Porifera / Q000737:chemistry; D012717:Sesquiterpenes / Q000138:chemical synthesis* / Q000737:chemistry; D013237:Stereoisomerism
chemical_list: D004224:Diterpenes; D012717:Sesquiterpenes; C455540:aureol; C109395:sclareolide