title: Long-term estrogen treatment of mice with a prothrombotic phenotype induces sustained increases in thrombin generation without affecting tissue fibrin deposition.
authors.affiliation: Einthoven Laboratory for Experimental Vascular Medicine, Department of Thrombosis and Hemostasis, Leiden University Medical Center, Leiden Laboratory for Clinical Thrombosis and Hemostasis, Department of Internal Medicine, Cardiovascular Research Institute Maastricht, Maastricht University Medical Center, Maastricht, the Netherlands.
authors.forename: A C A
authors.initials: AC
authors.lastname: Cleuren
authors.forename: R
authors.initials: R
authors.lastname: Van Oerle
authors.forename: P H
authors.initials: PH
authors.lastname: Reitsma
authors.forename: H M
authors.initials: HM
authors.lastname: Spronk
authors.forename: B J M
authors.initials: BJ
authors.lastname: Van Vlijmen
mesh_terms: D000284:Administration, Oral; D000818:Animals; D001331:Automation; D001777:Blood Coagulation / Q000187:drug effects / Q000235:genetics; D004967:Estrogens / Q000008:administration & dosage*; D004997:Ethinyl Estradiol / Q000008:administration & dosage*; D005165:Factor V / Q000235:genetics; D005337:Fibrin / Q000378:metabolism*; D006487:Hemostasis / Q000187:drug effects; D051379:Mice; D008810:Mice, Inbred C57BL; D009154:Mutation; D010641:Phenotype; D011392:Proline / Q000235:genetics; D013917:Thrombin / Q000378:metabolism*; D018180:Thrombomodulin / Q000235:genetics; D013997:Time Factors
chemical_list: D004967:Estrogens; D018180:Thrombomodulin; C095381:factor V Leiden; D004997:Ethinyl Estradiol; D005165:Factor V; D005337:Fibrin; D011392:Proline; D013917:Thrombin