title: Clinical outcome of non-surgical treatment for primary small intestinal lymphoma diagnosed with double-balloon endoscopy.
abstract: Primary small intestinal lymphoma (PSIL) is often treated with surgical resection, and therefore response to non-surgical treatment is rarely known. We retrospectively analyzed the clinicopathological features of 19 patients with PSIL, who had been diagnosed by double-balloon endoscopy (DBE) and had not received surgical treatment. The immunohistological phenotypes of 18 patients were B-cell lymphomas. Five patients had tumors within the jejunum, nine within the ileum and five in multiple sites including the duodenum. Most cases were in the low or low-intermediate risk group of the International Prognostic Index score. Seventeen patients received chemotherapy, with an overall response rate of 82.4%. The estimated overall survival at 5 years was 72.2%. Response to initial chemotherapy and levels of hemoglobin (Hb) and albumin (Alb) were identified as favorable prognostic indicators. We conclude that PSIL can be effectively diagnosed by DBE and shows a good prognosis with chemotherapy alone.
authors.affiliation: Division of Hematology, Department of Internal Medicine, Jichi Medical University, Tochigi, Japan. kobahiro@jichi.ac.jp
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Kobayashi
authors.forename: Tadashi
authors.initials: T
authors.lastname: Nagai
authors.forename: Ken
authors.initials: K
authors.lastname: Omine
authors.forename: Kazuya
authors.initials: K
authors.lastname: Sato
authors.forename: Katsutoshi
authors.initials: K
authors.lastname: Ozaki
authors.forename: Takahiro
authors.initials: T
authors.lastname: Suzuki
authors.forename: Masaki
authors.initials: M
authors.lastname: Mori
authors.forename: Kazuo
authors.initials: K
authors.lastname: Muroi
authors.forename: Tomonori
authors.initials: T
authors.lastname: Yano
authors.forename: Hironori
authors.initials: H
authors.lastname: Yamamoto
authors.forename: Keiya
authors.initials: K
authors.lastname: Ozawa
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D058582:Double-Balloon Enteroscopy; D005260:Female; D006801:Humans; D007414:Intestinal Neoplasms / Q000175:diagnosis* / Q000401:mortality / Q000628:therapy; D007421:Intestine, Small / Q000473:pathology*; D008228:Lymphoma, Non-Hodgkin / Q000175:diagnosis* / Q000401:mortality / Q000628:therapy; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D012189:Retrospective Studies; D016896:Treatment Outcome