title: Constituents from Vigna vexillata and their anti-inflammatory activity.
abstract: The seeds of Vigna genus are important food resources and there have already been many reports regarding their bioactivities. In our preliminary bioassay, the chloroform layer of methanol extracts of V. vexillata demonstrated significant anti-inflammatory bioactivity. Therefore, the present research is aimed to purify and identify the anti-inflammatory principles of V. vexillata. One new sterol (1) and two new isoflavones (2,3) were reported from the natural sources for the first time and their chemical structures were determined by the spectroscopic and mass spectrometric analyses. In addition, 37 known compounds were identified by comparison of their physical and spectroscopic data with those reported in the literature. Among the isolates, daidzein (23), abscisic acid (25), and quercetin (40) displayed the most significant inhibition of superoxide anion generation and elastase release.
authors.affiliation: Graduate Institute of Natural Products, Chang Gung University, Taoyuan 333, Taiwan.|Chinese Herbal Medicine Research Team, Healthy Aging Research Center, Chang Gung University, Taoyuan 333, Taiwan.
authors.forename: Yann-Lii
authors.initials: YL
authors.lastname: Leu
authors.affiliation: Graduate Institute of Natural Products, Chang Gung University, Taoyuan 333, Taiwan.|Chinese Herbal Medicine Research Team, Healthy Aging Research Center, Chang Gung University, Taoyuan 333, Taiwan.
authors.forename: Tsong-Long
authors.identifier: 0000-0002-5780-3977
authors.initials: TL
authors.lastname: Hwang
authors.affiliation: Department of Biotechnology, National Formosa University, Yunlin 632, Taiwan.
authors.forename: Ping-Chung
authors.initials: PC
authors.lastname: Kuo
authors.affiliation: Department of Biotechnology, National Formosa University, Yunlin 632, Taiwan.
authors.forename: Kun-Pei
authors.initials: KP
authors.lastname: Liou
authors.affiliation: Department of Biotechnology, National Formosa University, Yunlin 632, Taiwan.
authors.forename: Bow-Shin
authors.initials: BS
authors.lastname: Huang
authors.affiliation: Department of Chemistry, National Chung-Hsing University, Taichung 402, Taiwan.
authors.forename: Guo-Feng
authors.initials: GF
authors.lastname: Chen
mesh_terms: D000328:Adult; D000893:Anti-Inflammatory Agents / Q000494:pharmacology*; D007887:Fabaceae / Q000737:chemistry*; D006801:Humans; D015394:Molecular Structure; D009504:Neutrophils / Q000187:drug effects* / Q000378:metabolism; D010196:Pancreatic Elastase / Q000378:metabolism; D012639:Seeds / Q000737:chemistry*; D013481:Superoxides / Q000378:metabolism; D055815:Young Adult
chemical_list: D000893:Anti-Inflammatory Agents; D013481:Superoxides; D010196:Pancreatic Elastase