title: Pyrone and unusually furanone-substituted flavones from the leaves of Hoslundia opposita.
abstract: Two new unusual 6-furanoflavones, hoslunfuranine (5) and 5-O-methylhoslunfuranine (6), were isolated from the leaves of Hoslundia opposita Vahl.. Four known methylpyranoflavonic analogues [hosloppin (1), hoslundin (2), 5-O-methylhoslundin (3), oppositin (4)], all specific of the species, were also obtained. Their structures were established on the basis of their spectroscopic data. In vitro cytotoxic, trypanocidal, and leishmanicidal activities of compounds 1 and 3 to 6 were evaluated. Compounds 4 and 6 exhibited leishmanicidal potential in the micromolar range.
authors.affiliation: Chimie des Substances Naturelles, CNRS UMR 8076 BioCIS, Labex LERMIT, Faculté de Pharmacie, Université Paris-Sud, Châtenay-Malabry, France.
authors.forename: Rim
authors.initials: R
authors.lastname: Salame
authors.forename: Zakaria
authors.initials: Z
authors.lastname: Cheikh-Ali
authors.forename: Christian
authors.initials: C
authors.lastname: Bories
authors.forename: Marcelline
authors.initials: M
authors.lastname: Adiko
authors.forename: Erwan
authors.initials: E
authors.lastname: Poupon
authors.forename: Pierre
authors.initials: P
authors.lastname: Champy
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D000981:Antiprotozoal Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D047309:Flavones / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D006801:Humans; D007624:KB Cells; D019686:Lamiaceae / Q000737:chemistry*; D007893:Leishmania donovani / Q000187:drug effects; D009682:Magnetic Resonance Spectroscopy; D021261:Parasitic Sensitivity Tests; D018515:Plant Leaves / Q000737:chemistry*; D011753:Pyrones / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D014346:Trypanosoma brucei brucei / Q000187:drug effects
chemical_list: C580792:5-O-methylhoslunfuranine; D000972:Antineoplastic Agents, Phytogenic; D000981:Antiprotozoal Agents; D047309:Flavones; D011753:Pyrones; C580791:hosloppin; C580790:oppositin