title: Lack of association between two key SNPs on chromosome 12p13 and ischemic stroke in Chinese Uyghur population.
abstract: Recent genome-wide association studies (GWAS) have identified two key SNPs (rs11833579 and rs12425791) on chromosome 12p13 that were significantly associated with stroke in Caucasians. However, the validity of the association has remained controversial. We performed genetic association analyses in a very unique population which has 60% European ancestry and 40% East Asian ancestry. No significant association between these two SNPs and ischemic stroke was detected in this Chinese Uyghur population.
authors.affiliation: Center for Disease Control and Prevention, Hubei 430079, China.
authors.forename: Yeqing
authors.initials: Y
authors.lastname: Tong
authors.forename: Faxian
authors.initials: F
authors.lastname: Zhan
authors.forename: Jinjun
authors.initials: J
authors.lastname: Han
authors.forename: Yanwei
authors.initials: Y
authors.lastname: Zhang
authors.forename: Xiaoxu
authors.initials: X
authors.lastname: Yin
authors.forename: Yijie
authors.initials: Y
authors.lastname: Geng
authors.forename: Shuangyi
authors.initials: S
authors.lastname: Hou
authors.forename: Jianjun
authors.initials: J
authors.lastname: Ye
authors.forename: Xuhua
authors.initials: X
authors.lastname: Guan
authors.forename: Shenhong
authors.initials: S
authors.lastname: Han
authors.forename: Yunxia
authors.initials: Y
authors.lastname: Wang
authors.forename: Katherine A
authors.initials: KA
authors.lastname: Mason
authors.forename: Zuxun
authors.initials: Z
authors.lastname: Lu
authors.forename: Jiafa
authors.initials: J
authors.lastname: Liu
authors.forename: Jinquan
authors.initials: J
authors.lastname: Cheng
mesh_terms: D000368:Aged; D000483:Alleles; D044383:Black People / Q000235:genetics; D001786:Blood Glucose / Q000032:analysis; D002545:Brain Ischemia / Q000208:ethnology / Q000235:genetics*; D016022:Case-Control Studies; D002508:Cephalometry; D002681:China / Q000453:epidemiology; D002881:Chromosomes, Human, Pair 12 / Q000235:genetics*; D015897:Comorbidity; D005006:Ethnicity / Q000235:genetics* / Q000266:history / Q000706:statistics & numerical data; D005060:Europe / Q000208:ethnology; D005202:Asia, Eastern / Q000208:ethnology; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D055106:Genome-Wide Association Study; D006239:Haplotypes; D049690:History, Ancient; D063426:Human Migration / Q000266:history; D006801:Humans; D008055:Lipids / Q000097:blood; D008074:Lipoproteins / Q000097:blood; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors; D044465:White People / Q000235:genetics
chemical_list: D001786:Blood Glucose; D008055:Lipids; D008074:Lipoproteins