title: Cytogenetics findings in a histiocytic sarcoma case.
abstract: Histiocytic sarcoma (HS) is a neoplasm derived from histiocytes. Its diagnosis was not clear until its immunohistochemistry profile was correctly established. Not much is known about its genetic properties. We report a case of a 48-year-old male patient whose bone marrow was almost completely occupied by monomorphic medium size neoplastic cellularity. Its immunohistochemical profile was CD68(+), CD4(+), CD45(+) with negativity of other dendritic cells, and other lineage markers. Cytogenetic study showed 4 related clones: one with trisomy 8 and extra material on the short arms of chromosome 4; a second line with tetrasomy of chromosome 8, add(4)(p16); the third clone had the same alterations as the previous and deletion of chromosome 3 at q11; the fourth line had tetrasomy 8 and translocation t(3;5)(q25;q35). To our knowledge this is the first HS case showing chromosome 8 trisomy and tetrasomy and the other described alterations.
authors.affiliation: Servicio de Hematología, Hospital Ramón y Cajal, Carretera de Colmenar Km 9, 100 28049 Madrid, Spain.
authors.forename: J M
authors.initials: JM
authors.lastname: Alonso-Dominguez
authors.forename: M
authors.initials: M
authors.lastname: Calbacho
authors.forename: M
authors.initials: M
authors.lastname: Talavera
authors.forename: C
authors.initials: C
authors.lastname: Villalon
authors.forename: L
authors.initials: L
authors.lastname: Abalo
authors.forename: J V
authors.initials: JV
authors.lastname: Garcia-Gutierrez
authors.forename: S
authors.initials: S
authors.lastname: Lozano
authors.forename: M
authors.initials: M
authors.lastname: Tenorio
authors.forename: J
authors.initials: J
authors.lastname: Villarrubia
authors.forename: J
authors.initials: J
authors.lastname: Lopez-Jimenez
authors.forename: M T
authors.initials: MT
authors.lastname: Ferro