title: [Can mannose-binding lectin and plasma level of soluble urokinase receptor be used in diagnosis and treatment monitorization of brucellosis patients?].
abstract: The aim of this study was to evaluate the diagnostic value of serum mannose-binding lectin (MBL) and plasma soluble urokinase plasminogen activator receptor (SuPAR) levels in monitoring the treatment in patients with brucellosis, by comparing their levels before and after treatment with the values obtained from healthy control group. Thirty brucellosis patients (mean age: 25.8 ± 12.2 years; 15 were male) and 28 healthy controls (mean age: 29.3 ± 12.3 years; 15 were male) were included in the study. Patients were diagnosed with brucellosis according to the characteristic clinical findings and by brucella standard tube agglutination test (SAT) titer ≥ 1/160 and/or blood culture positivity. Serum MBL (Antibodyshop, Denmark) and plasma SuPAR (Virogates, Denmark) levels were investigated with commercial ELISA kits. In our study, no statistical significance was observed between the pre-treatment (13.8 ± 13.4 ng/ml) and post-treatment (12.4 ± 13.1 ng/ml) MBL levels of the patient group and MBL levels of the control group (16.5 ± 14.8 ng/ml) (p> 0.05). Moreover, the mean SuPAR levels measured in pre-treatment and post-treatment plasma samples of the brucellosis patients was 5.1 ± 1.9 ng/ml and 2.9 ± 1.3 ng/ml, respectively, while the mean SuPAR level was 1.8 ± 0.5 ng/ml in the control group. The difference between mean SuPAR levels of patients in pre- and post-treatment samples was found statistically significant (p< 0.001). In addition SuPAR levels were significantly higher in patients before and after treatment than the control group (p> 0.001). In conclusion, plasma SuPAR level would be a useful marker for the diagnosis and treatment follow up of the patients with brucellosis.
authors.forename: Hasan
authors.initials: H
authors.lastname: Karsen
authors.forename: Salih
authors.initials: S
authors.lastname: Cesur
authors.forename: Leman
authors.initials: L
authors.lastname: Karaağaç
authors.forename: Irfan
authors.initials: I
authors.lastname: Binici
authors.forename: Yasemin
authors.initials: Y
authors.lastname: Fidan
authors.forename: Elmas
authors.initials: E
authors.lastname: Oğüş
authors.forename: Ali Pekcan
authors.initials: AP
authors.lastname: Demiröz
mesh_terms: D000328:Adult; D000372:Agglutination Tests; D015415:Biomarkers / Q000097:blood; D002006:Brucellosis / Q000097:blood / Q000175:diagnosis* / Q000628:therapy; D016022:Case-Control Studies; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D008297:Male; D037601:Mannose-Binding Lectin / Q000097:blood*; D055293:Receptors, Urokinase Plasminogen Activator / Q000097:blood*
chemical_list: D015415:Biomarkers; D037601:Mannose-Binding Lectin; D055293:Receptors, Urokinase Plasminogen Activator