title: Rapid screening and determination of designer drugs in saliva by a nib-assisted paper spray-mass spectrometry and separation technique.
abstract: A method for the rapid screening and determination of amphetamine-type designer drugs in saliva by a novel nib-assisted paper spray-mass spectrometry procedure is described. Under optimized conditions, the limit of detections for amphetamine derivatives (model samples: o-, m-, p-chloroamphetamine and o-, m-, p-fluoroamphetamine, respectively) were determined to 0.1 μg/mL by the nib-assisted paper spray-mass spectrometry method. This method is easier and has a higher sensitivity than similar methodologies, including atmospheric pressure/matrix-assisted laser desorption ionization mass spectrometry and electrospray-assisted laser desorption ionization/mass spectrometry. Data obtained using more classical separation methods, including liquid chromatography and capillary electrophoresis, are also reported.
authors.affiliation: Department of Chemistry, National Taiwan Normal University, Taipei, Taiwan.
authors.forename: Hsun
authors.initials: H
authors.lastname: Lee
authors.forename: Chih-Sheng
authors.initials: CS
authors.lastname: Jhang
authors.forename: Ju-Tsung
authors.initials: JT
authors.lastname: Liu
authors.forename: Cheng-Huang
authors.initials: CH
authors.lastname: Lin
mesh_terms: D000661:Amphetamine / Q000032:analysis*; D015198:Designer Drugs / Q000032:analysis*; D006801:Humans; D013058:Mass Spectrometry / Q000295:instrumentation / Q000379:methods*; D012463:Saliva / Q000737:chemistry*; D015813:Substance Abuse Detection / Q000379:methods*
chemical_list: D015198:Designer Drugs; D000661:Amphetamine