title: Association between anti-thyroid peroxidase antibody and asthma in women.
abstract: About 8% of the general population suffers from autoimmune diseases, from which 78% are women. One of the most important causes of thyroid diseases is autoimmunity in origin, and it seems that people with thyroid diseases present more signs of asthma. This study was therefore designed to investigate the frequency of autoimmune thyroid diseases in women suffering from bronchial asthma.In a cross-sectional study, 100 women with asthma and 100 women as control group were tested for thyroid function and anti-thyroid peroxidase antibody (anti-TPO Ab) measurements. The asthmatic patients were selected based on having chronic cough, dyspnea, wheezing and clinical examination of the chest. The diagnosis was confirmed by pulmonary function tests. Blood tests were done by electrochemiluminescence immunoassay method.No hyperthyroid patient was found in either group. Serum TSH and Total T4 levels were not statistically different between the two groups, but serum anti-TPO Ab levels in women with asthma (74±13.6 IU/ml) was significantly higher than control group (45.24±10.56 IU/ml). After adjusting the effect of age and BMI, the relationship between asthma and anti-TPO Ab (>50 IU/ml) was statistically significant (OR=3.3, P<0.01). Positive anti-TPO Ab in asthmatic patients may show presence of a hidden autoimmune thyroiditis in these patients. We suggested checking asthmatic patients for thyroid diseases.
authors.affiliation: Physiology Research Center, Kerman University of Medical Sciences, Kerman, Iran. m_samareh@kmu.ac.ir
authors.forename: Mitra
authors.initials: M
authors.lastname: Samareh Fekri
authors.forename: Mostafa
authors.initials: M
authors.lastname: Shokoohi
authors.forename: Mohammad-Hossein
authors.initials: MH
authors.lastname: Gozashti
authors.forename: Saeed
authors.initials: S
authors.lastname: Esmailian
authors.forename: Nasrollah
authors.initials: N
authors.lastname: Jamshidian
authors.forename: Malihe
authors.initials: M
authors.lastname: Shadkam-Farokhi
authors.forename: Mohammad-Reza
authors.initials: MR
authors.lastname: Lashkarizadeh
authors.forename: Reza
authors.initials: R
authors.lastname: Malekpour Afshar
mesh_terms: D000328:Adult; D001249:Asthma / Q000097:blood / Q000175:diagnosis / Q000453:epidemiology / Q000276:immunology*; D001323:Autoantibodies / Q000097:blood*; D001324:Autoantigens / Q000276:immunology*; D016022:Case-Control Studies; D016009:Chi-Square Distribution; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D007118:Immunoassay; D007453:Iodide Peroxidase / Q000276:immunology*; D007492:Iran / Q000453:epidemiology; D033862:Iron-Binding Proteins / Q000276:immunology*; D016015:Logistic Models; D008875:Middle Aged; D015999:Multivariate Analysis; D016017:Odds Ratio; D015995:Prevalence; D012129:Respiratory Function Tests; D013960:Thyroid Function Tests; D013967:Thyroiditis, Autoimmune / Q000453:epidemiology / Q000276:immunology; D015854:Up-Regulation
chemical_list: D001323:Autoantibodies; D001324:Autoantigens; D033862:Iron-Binding Proteins; C056626:thyroid microsomal antibodies; C056658:TPO protein, human; D007453:Iodide Peroxidase