title: Effects of anabolic androgenic steroids on chylomicron metabolism.
abstract: OBJECTIVE
  To evaluate the effects of anabolic androgenic steroids (AAS) on chylomicron metabolism.
  
  
  METHODS
  An artificial lipid emulsion labeled with radioactive cholesteryl ester (CE) and triglycerides (TG) mimicking chylomicrons was intravenously injected into individuals who regularly weight trained and made regular use of AAS (WT+AAS group), normolipidemic sedentary individuals (SDT group) and individuals who also regularly weight trained but did not use AAS (WT group). Fractional clearance rates (FCR) were determined by compartmental analysis for emulsion plasma decay curves.
  
  
  RESULTS
  FCR-CE for the WT+AAS group was reduced (0.0073 ± 0.0079 min(-1), 0.0155 ± 0.0100 min(-1), 0.0149 ± 0.0160 min(-1), respectively; p<0.05), FCR-TG was similar for both the WT and SDT groups. HDL-C plasma concentrations were lower in the WT+AAS group when compared to the WT and SDT groups (22 ± 13; 41 ± 7; 38 ± 13 mg/dL, respectively; p<0.001). Hepatic triglyceride lipase activity was greater in the WT+AAS group when compared to the WT and SDT groups (7243 ± 1822; 3898 ± 1232; 2058 ± 749, respectively; p<0.001). However, no difference was observed for lipoprotein lipase activity.
  
  
  CONCLUSIONS
  Data strongly suggest that AAS may reduce the removal from the plasma of chylomicron remnants, which are known atherogenic factors.
authors.affiliation: Heart Institute (InCor) of Medical School Hospital, University of São Paulo, São Paulo, Brazil.
authors.forename: Aleksandra T
authors.initials: AT
authors.lastname: Morikawa
authors.forename: Raul C
authors.initials: RC
authors.lastname: Maranhão
authors.forename: Maria-Janieire N N
authors.initials: MJ
authors.lastname: Alves
authors.forename: Carlos E
authors.initials: CE
authors.lastname: Negrão
authors.forename: Jeferson L
authors.initials: JL
authors.lastname: da Silva
authors.forename: Carmen G C
authors.initials: CG
authors.lastname: Vinagre
mesh_terms: D000328:Adult; D000728:Androgens / Q000494:pharmacology*; D002914:Chylomicrons / Q000737:chemistry / Q000378:metabolism*; D006801:Humans; D008297:Male; D055070:Resistance Training; D057185:Sedentary Behavior; D013256:Steroids / Q000494:pharmacology*; D014280:Triglycerides / Q000737:chemistry
chemical_list: D000728:Androgens; D002914:Chylomicrons; D013256:Steroids; D014280:Triglycerides