title: Association between urinary concentrations of bisphenol A and type 2 diabetes in Korean adults: a population-based cross-sectional study.
abstract: Bisphenol A (BPA) is a synthetic phenolic compound to which the general public may be exposed via consumer products and environmental contamination. We assessed the association between urinary BPA concentration and the prevalence of type 2 diabetes. This cross-sectional study included Korean adult participants (n=1210) aged 40-69 years and was based on the 2009 Korean National Human Biomonitoring Survey. Demographic characteristics and medical history of type 2 diabetes were collected from the participants by questionnaire, and BPA levels were determined by analysis of urine samples. The mean age of the participants was 53.4 years and 41.6% were men; the prevalence of type 2 diabetes differed according to demographic characteristics. The geometric mean urinary BPA levels of participants with and without type 2 diabetes were 2.03 and 2.40ng/mL, respectively. Among BPA quartiles, no clear association was found between BPA levels and type 2 diabetes. Although the adjusted odds ratio of type 2 diabetes was slightly increased for participants in the upper BPA quartile, the association was not statistically significant. These findings suggest that a high body BPA burden may not be associated with an increased prevalence of type 2 diabetes in Korean adults.
authors.affiliation: Department of Pharmacy, Keimyung University, Daegu, Republic of Korea. kimkisok@kmu.ac.kr
authors.forename: Kisok
authors.initials: K
authors.lastname: Kim
authors.forename: Hyejin
authors.initials: H
authors.lastname: Park
mesh_terms: D000328:Adult; D000368:Aged; D044466:Asian People; D001559:Benzhydryl Compounds / Q000652:urine*; D003430:Cross-Sectional Studies; D003924:Diabetes Mellitus, Type 2 / Q000453:epidemiology / Q000652:urine*; D004784:Environmental Monitoring; D004785:Environmental Pollutants / Q000652:urine*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D010636:Phenols / Q000652:urine*; D015995:Prevalence; D056910:Republic of Korea / Q000453:epidemiology; D000098826:Bisphenol A Compounds
chemical_list: D001559:Benzhydryl Compounds; D004785:Environmental Pollutants; D010636:Phenols; C006780:bisphenol A; D000098826:Bisphenol A Compounds