title: Both projection and commissural pathways are disrupted in individuals with chronic stroke: investigating microstructural white matter correlates of motor recovery.
abstract: BACKGROUND
  Complete recovery of motor function after stroke is rare with deficits persisting into the chronic phase of recovery. Diffusion tensor imaging (DTI) can evaluate relationships between white matter microstructure and motor function after stroke. The objective of this investigation was to characterize microstructural fiber integrity of motor and sensory regions of the corpus callosum (CC) and descending motor outputs of the posterior limb of the internal capsule (PLIC) in individuals with chronic stroke and evaluate the relationships between white matter integrity and motor function.
  
  
  RESULTS
  Standardized measures of upper extremity motor function were measured in thirteen individuals with chronic stroke. Manual dexterity was assessed in thirteen healthy age-matched control participants. DTI scans were completed for each participant. Fractional anisotropy (FA) of a cross-section of sensory and motor regions of the CC and the PLIC bilaterally were quantified. Multivariate analysis of variance evaluated differences between stroke and healthy groups. Correlational analyses were conducted for measures of motor function and FA. The stroke group exhibited reduced FA in the sensory (p = 0.001) region of the CC, contra- (p = 0.032) and ipsilesional (p = 0.001) PLIC, but not the motor region of the CC (p = 0.236). In the stroke group, significant correlations between contralesional PLIC FA and level of physical impairment (p = 0.005), grip strength (p = 0.006) and hand dexterity (p = 0.036) were observed.
  
  
  CONCLUSIONS
  Microstructural status of the sensory region of the CC is reduced in chronic stroke. Future work is needed to explore relationships between callosal sensorimotor fiber integrity and interhemispheric interactions post-stroke. In addition, contralesional primary motor output tract integrity is uniquely and closely associated with multiple dimensions of motor recovery in the chronic phase of stroke suggesting it may be an important biomarker of overall motor recovery.
authors.affiliation: Department of Physical Therapy, Faculty of Medicine, University of British Columbia, Vancouver, British Columbia, Canada.
authors.forename: Michael R
authors.initials: MR
authors.lastname: Borich
authors.forename: Cameron
authors.initials: C
authors.lastname: Mang
authors.forename: Lara A
authors.initials: LA
authors.lastname: Boyd
mesh_terms: D000368:Aged; D016880:Anisotropy; D016022:Case-Control Studies; D002908:Chronic Disease; D003337:Corpus Callosum / Q000473:pathology* / Q000503:physiopathology; D056324:Diffusion Tensor Imaging / Q000379:methods / Q000523:psychology; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods; D020772:Internal Capsule / Q000473:pathology* / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D009048:Motor Skills / Q000502:physiology*; D009413:Nerve Fibers, Myelinated / Q000648:ultrastructure*; D009434:Neural Pathways / Q000473:pathology; D059906:Neuroimaging / Q000379:methods / Q000523:psychology*; D020127:Recovery of Function / Q000502:physiology*; D020521:Stroke / Q000473:pathology* / Q000503:physiopathology