title: Maternal antibiotic exposure and risk of antibiotic resistance in neonatal early-onset sepsis: a case-cohort study.
abstract: In a case-cohort study of early-onset sepsis, antibiotic resistance was more likely for infections in neonates born to mothers who were given antibiotics during pregnancy (odds ratio 4.6; 95% confidence interval: 1.1-19;P = 0.05). Risk of resistance increased with duration of antibiotics and number of antibiotic courses during pregnancy. Preterm birth and hospitalization during pregnancy were also associated with resistance. These risk factors should be considered when selecting empiric antibiotics for therapy of early-onset sepsis in infants.
authors.affiliation: Division of Infectious Disease, University of British Columbia, Vancouver, British Columbia, Canada.
authors.forename: Alissa Jade
authors.initials: AJ
authors.lastname: Wright
authors.forename: Sharon
authors.initials: S
authors.lastname: Unger
authors.forename: Brenda L
authors.initials: BL
authors.lastname: Coleman
authors.forename: Po-Po
authors.initials: PP
authors.lastname: Lam
authors.forename: Allison J
authors.initials: AJ
authors.lastname: McGeer
mesh_terms: D000328:Adult; D000900:Anti-Bacterial Agents / Q000494:pharmacology / Q000627:therapeutic use*; D016470:Bacteremia / Q000188:drug therapy / Q000382:microbiology; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D016920:Meningitis, Bacterial / Q000188:drug therapy / Q000382:microbiology; D011247:Pregnancy; D047928:Premature Birth; D012141:Respiratory Tract Infections / Q000188:drug therapy / Q000382:microbiology; D018805:Sepsis / Q000209:etiology*; D014552:Urinary Tract Infections / Q000188:drug therapy / Q000382:microbiology
chemical_list: D000900:Anti-Bacterial Agents