title: Status of clomiphene citrate and metformin for infertility in PCOS.
abstract: Though widely used, there is uncertainty about the effectiveness and adverse effects of metformin and clomiphene citrate (CC) for infertility in polycystic ovary syndrome (PCOS). A systematic review (SR) of the best available evidence suggests that both CC and metformin are better than placebo for increasing ovulation and pregnancy rates, but CC is more effective than metformin for ovulation, pregnancy and live-birth rates, in PCOS patients with body mass index (BMI) >30. A combination of CC and metformin is superior to either metformin alone or CC alone, depending on the BMI and CC sensitivity of the patient. This SR provides key messages to guide clinicians and consumers on the use of these interventions in different subgroups of women with PCOS.
authors.affiliation: Women's Public Health Research, School of Public Health and Preventive Medicine, Monash University, Melbourne, Australia 3168. marie.misso@monash.edu
authors.forename: Marie L
authors.initials: ML
authors.lastname: Misso
authors.forename: Helena J
authors.initials: HJ
authors.lastname: Teede
authors.forename: Roger
authors.initials: R
authors.lastname: Hart
authors.forename: Jennifer
authors.initials: J
authors.lastname: Wong
authors.forename: Luk
authors.initials: L
authors.lastname: Rombauts
authors.forename: Angela M
authors.initials: AM
authors.lastname: Melder
authors.forename: Robert J
authors.initials: RJ
authors.lastname: Norman
authors.forename: Michael F
authors.initials: MF
authors.lastname: Costello
mesh_terms: D002996:Clomiphene / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D007247:Infertility, Female / Q000188:drug therapy*; D008687:Metformin / Q000627:therapeutic use*; D010062:Ovulation Induction; D011085:Polycystic Ovary Syndrome / Q000188:drug therapy* / Q000503:physiopathology
chemical_list: D002996:Clomiphene; D008687:Metformin