title: Expression of BMP2, TLR3, TLR4 and COX2 in colorectal polyps, adenoma             and adenocarcinoma.
abstract: The initiation and development of colorectal cancer is closely associated             with the malignant transformation of colorectal polyps. The aim of this study             was to analyze the expression of the bone morphogenetic protein-2 (BMP2), toll-like             receptor 3 (TLR3), TLR4 and cyclooxygenase-2 (COX2) proteins in colorectal polyps,             adenoma and adenocarcinoma. An immunohistochemical streptavidin-peroxidase (SP)             method was used to examine the expression of MBP2, TLR4, TLR3 and COX2 in 20 colorectal             juvenile polyps and 15 colorectal polyps of hamartomatous polyposis obtained from             children, and 20 colorectal adenomas and 20 colorectal adenocarcinomas obtained             from adults. A comparison of the expression levels of TLR3 among the groups revealed             a gradual downward trend from the colorectal juvenile polyp group to the colorectal             hamartomatous polyposis, adenoma and adenocarcinoma groups, respectively. The             expression level of TLR3 was significantly lower in the colorectal adenocarcinoma             group (p<0.05). The expression levels of TLR3, TLR4 and BMP2 were significantly             different among the colorectal juvenile polyp, hamartomatous polyposis, adenoma             and adenocarcinoma groups. These three protein molecules may be significant in             the development and malignant transformation of colorectal polyps.
authors.affiliation: Department of Ministry of Education, Key Laboratory of Child Development and Disorders, Children's Hospital of Chongqing Medical University, Chongqing 400014, PR China.
authors.forename: Li
authors.initials: L
authors.lastname: Xiang
authors.forename: Shiqi
authors.initials: S
authors.lastname: Wang
authors.forename: Xianqing
authors.initials: X
authors.lastname: Jin
authors.forename: Wenjuan
authors.initials: W
authors.lastname: Duan
authors.forename: Xionghui
authors.initials: X
authors.lastname: Ding
authors.forename: Chang
authors.initials: C
authors.lastname: Zheng
mesh_terms: D000230:Adenocarcinoma / Q000378:metabolism* / Q000473:pathology; D000236:Adenoma / Q000378:metabolism* / Q000473:pathology; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D055396:Bone Morphogenetic Protein 2 / Q000378:metabolism*; D002648:Child; D002675:Child, Preschool; D003111:Colonic Polyps / Q000378:metabolism* / Q000473:pathology; D015179:Colorectal Neoplasms / Q000378:metabolism* / Q000473:pathology; D051546:Cyclooxygenase 2 / Q000378:metabolism*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D007223:Infant; D008297:Male; D008875:Middle Aged; D051196:Toll-Like Receptor 3 / Q000378:metabolism*; D051197:Toll-Like Receptor 4 / Q000378:metabolism*
chemical_list: D055396:Bone Morphogenetic Protein 2; D051196:Toll-Like Receptor 3; D051197:Toll-Like Receptor 4; D051546:Cyclooxygenase 2