title: Co-existence of chronic urticaria and metabolic syndrome: clinical implications.
abstract: A systemic pro-inflammatory and pro-coagulating state occurs in subjects who have both chronic urticaria and metabolic syndrome. To investigate the prevalence and clinical impact of metabolic syndrome in Korean patients with chronic urticaria, a hospital-based cross-sectional study of 131 patients was performed. Metabolic syndrome was assessed by the criteria of the National Cholesterol Education Program's Adult Treatment Panel III. Urticaria disease activity was assessed by total urticaria activity score (range 0-15). Thirty-nine patients (29.8%) had metabolic syndrome compared to 17.8% in a matched control group (p=0.001). Patients with chronic urticaria and metabolic syndrome were older, had a higher mean urticaria activity score and serum levels of eosinophil cationic protein, tumour necrosis factor-α, and complements, and showed a higher rate of negative autologous serum skin tests compared with those with-out metabolic syndrome. Logistic regression analysis indicated that an urticaria activity score of ≥ 13 (p=0.025) and the presence of metabolic syndrome (p=0.036) were independent predictors of uncontrolled chronic urticaria. We conclude that patients with severe and uncontrolled chronic urticaria should be evaluated for metabolic syndrome in order to reduce cardiovascular risk and improve chronic urticaria outcomes.
authors.affiliation: Department of Allergy and Clinical Immunology, Ajou University School of Medicine, Suwon, Korea.
authors.forename: Young-Min
authors.initials: YM
authors.lastname: Ye
authors.forename: Hyun-Jung
authors.initials: HJ
authors.lastname: Jin
authors.forename: Eui-Kyung
authors.initials: EK
authors.lastname: Hwang
authors.forename: Young-Hee
authors.initials: YH
authors.lastname: Nam
authors.forename: Joo-Hee
authors.initials: JH
authors.lastname: Kim
authors.forename: Yoo-Seob
authors.initials: YS
authors.lastname: Shin
authors.forename: Hae-Sim
authors.initials: HS
authors.lastname: Park
mesh_terms: D000328:Adult; D000368:Aged; D000704:Analysis of Variance; D015415:Biomarkers / Q000097:blood; D016022:Case-Control Studies; D016009:Chi-Square Distribution; D002908:Chronic Disease; D003165:Complement System Proteins / Q000032:analysis; D003430:Cross-Sectional Studies; D047150:Eosinophil Cationic Protein / Q000097:blood; D005260:Female; D006801:Humans; D016015:Logistic Models; D008297:Male; D024821:Metabolic Syndrome / Q000097:blood / Q000175:diagnosis / Q000453:epidemiology* / Q000276:immunology; D008875:Middle Aged; D011237:Predictive Value of Tests; D015995:Prevalence; D056910:Republic of Korea / Q000453:epidemiology; D018570:Risk Assessment; D012307:Risk Factors; D012882:Skin Tests; D014409:Tumor Necrosis Factor-alpha / Q000097:blood; D014581:Urticaria / Q000097:blood / Q000175:diagnosis / Q000453:epidemiology* / Q000276:immunology; D055815:Young Adult
chemical_list: D015415:Biomarkers; D014409:Tumor Necrosis Factor-alpha; D003165:Complement System Proteins; D047150:Eosinophil Cationic Protein; C479220:RNASE3 protein, human