title: Neonatal infections in China, Malaysia, Hong Kong and Thailand.
abstract: OBJECTIVE
  Neonatal sepsis is a major cause of neonatal deaths in Asia but data remain scarce. We aimed to investigate the causative organisms and antibiotic resistance in neonatal care units in China, Malaysia, Hong Kong and Thailand.
  
  
  METHODS
  Prospective cohort study of neonatal sepsis defined as positive culture of a single potentially pathogenic organism from blood or cerebrospinal fluid differentiated into early-onset sepsis (EOS) occurring <3 days of birth and late-onset sepsis (LOS) ≥3 days after birth.
  
  
  RESULTS
  During the study period, there were 963 episodes of neonatal sepsis. The incidence of EOS was 0.62 (95% CI 0.45 to 0.82) per 1000 live births or 4.91 (95% CI 4.22 to 5.68) per 1000 admissions while the incidence of LOS was 5.00 (95% CI 4.51 to 5.53) per 1000 live births or 21.22 (95% CI 19.79 to 22.77) per 1000 admissions. The incidence of Group B Streptococcus (GBS) sepsis was low but remained the most common single pathogen for EOS among inborn babies. Klebsiella spp. was the most common Gram-negative organism causing most deaths. The case-fatality was 7.0% (95% CI 3.9% to 12.0%) for EOS and 16.0% (95% CI 13.7% to 19.0%) for LOS, and was significantly different between participating units after adjusting for potential confounders. Of all Gram-negative organisms, 47%, 37% and 32% were resistant to third-generation cephalosporins, gentamicin or both, respectively.
  
  
  CONCLUSIONS
  The pattern of EOS in Asian settings is similar to that in industrialised countries with low incidence of GBS sepsis. The important features of neonatal sepsis in Asia are the burden of Klebsiella spp. and high level of antibiotic resistance. These should be addressed while developing measures to reduce neonatal mortality due to infection.
authors.affiliation: Department of Infectious Diseases and Microbiology, Children's Hospital at Westmead, Sydney, NSW, 2145, Australia. davidi@chw.edu.au
authors.forename: Abdullah
authors.initials: A
authors.lastname: Al-Taiar
authors.forename: Majeda S
authors.initials: MS
authors.lastname: Hammoud
authors.forename: Liu
authors.initials: L
authors.lastname: Cuiqing
authors.forename: Jimmy K F
authors.initials: JK
authors.lastname: Lee
authors.forename: Kin-Man
authors.initials: KM
authors.lastname: Lui
authors.forename: Narongsak
authors.initials: N
authors.lastname: Nakwan
authors.forename: David
authors.initials: D
authors.lastname: Isaacs
mesh_terms: D002681:China / Q000453:epidemiology; D015331:Cohort Studies; D004352:Drug Resistance, Microbial; D005260:Female; D006723:Hong Kong / Q000453:epidemiology; D006801:Humans; D015994:Incidence; D007226:Infant Mortality; D007231:Infant, Newborn; D008296:Malaysia / Q000453:epidemiology; D008297:Male; D011446:Prospective Studies; D018805:Sepsis / Q000453:epidemiology* / Q000382:microbiology / Q000401:mortality; D013785:Thailand / Q000453:epidemiology