title: Increased arterial stiffness in patients with nephrotic syndrome.
abstract: BACKGROUND
  Nephrotic syndrome (NS) and arterial stiffness (AS) have each been linked with increased risk for cardiovascular diseases. However, there is no data in the literature up-to-date on AS in adult patients with NS. Thus, in this study, we aimed to evaluate the potential associations between AS, volume and nutritional status in patients with NS in comparison to a healthy control group.
  
  
  METHODS
  34 adult patients with newly diagnosed but untreated NS and 34 healthy controls were studied. AS was assessed by carotid-femoral PWV (cf-PWV) and body composition, nutritional status by multifrequency bioelectric impedance analysis (BIA).
  
  
  RESULTS
  Mean age was 44.6 ± 18.7 years (18 - 72). Mean cf-PWV was 8.3 ± 2.5 m/s in patients with NS and 6.7 ± 1.1 m/s in controls (p = 0.002) . In univariate analysis, cf-PWV and positively correlated with age, systolic blood pressure, mean arterial pressure (MAP), pulse pressure, body mass index, body fat ratio, waisthip ratio, creatinine, uric acid and negatively with creatinine clearance. In linear regression analysis, only age and MAP predicted arterial stiffness. Total body fluid, extracellular water (ECW), ECW/Height, ECW/body surface area and third space volumes were higher in patients with NS.
  
  
  CONCLUSIONS
  Patients with NS have increased AS and are more hypervolemic compared to the healthy subjects.
authors.affiliation: Ege University School of Medicine, Izmir, Turkey. ozkangungor@yahoo.com.tr
authors.forename: Ozkan
authors.initials: O
authors.lastname: Gungor
authors.forename: Meltem Sezis
authors.initials: MS
authors.lastname: Demirci
authors.forename: Fatih
authors.initials: F
authors.lastname: Kircelli
authors.forename: Erhan
authors.initials: E
authors.lastname: Tatar
authors.forename: Savas
authors.initials: S
authors.lastname: Sipahi
authors.forename: Ender
authors.initials: E
authors.lastname: Hur
authors.forename: Sait
authors.initials: S
authors.lastname: Sen
authors.forename: Huseyin
authors.initials: H
authors.lastname: Toz
authors.forename: Ali
authors.initials: A
authors.lastname: Basci
authors.forename: Ercan
authors.initials: E
authors.lastname: Ok
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D062186:Arterial Pressure / Q000502:physiology*; D001783:Blood Flow Velocity; D002339:Carotid Arteries / Q000503:physiopathology*; D003430:Cross-Sectional Studies; D005260:Female; D005263:Femoral Artery / Q000503:physiopathology*; D006801:Humans; D006973:Hypertension / Q000453:epidemiology / Q000209:etiology* / Q000503:physiopathology; D015994:Incidence; D008297:Male; D008875:Middle Aged; D009404:Nephrotic Syndrome / Q000150:complications / Q000503:physiopathology*; D014421:Turkey / Q000453:epidemiology; D059289:Vascular Stiffness / Q000502:physiology*; D055815:Young Adult