title: The activity of paraoxonase and arylesterase in patients with osteomyelitis.
abstract: BACKGROUND
  The aim of this study was to evaluate oxidative stress and to determine the activity of paraoxonase and arylesterase in patients with osteomyelitis compared to healthy controls.
  
  
  METHODS
  In total, 30 patients diagnosed with osteomyelitis and 30 healthy volunteers were enrolled in the study. Paraoxonase and arylesterase activities were measured spectrophotometrically. Serum lipid hydroperoxide (LOOH) concentrations were measured by ferrous oxidation with xylenol orange (FOX) assay as markers of oxidative stress.
  
  
  RESULTS
  Serum paraoxonase and arylesterase activities were significantly lower in patients with osteomyelitis compared to control individuals (all p < 0.05). Serum LOOH concentrations were significantly higher in patients with osteomyelitis than those in controls (p < 0.05). Arylesterase activity was inversely correlated with triglyceride (r =- 0.49; p = 0.005) and cholesterol concentrations (r =- 0.41; p = 0.025).
  
  
  CONCLUSIONS
  In light of the findings obtained from the present study, it may be assumed that decreased activity of serum paraoxonase and increased concentrations of LOOH observed in osteomyelitis patients appear to be related to the increased oxidative stress and inflammatory conditions present in these patients, and may cause a much more severe status of the disease.
authors.affiliation: Infectious Diseases and Clinical Microbiology Department, Faculty of Medicine, Harran University, Yenisehir Campus, 63100 Sanliurfa, Turkey. suda_tekinkoruk@yahoo.com
authors.forename: Suda
authors.initials: S
authors.lastname: Tekin Koruk
authors.forename: Nurten
authors.initials: N
authors.lastname: Aksoy
authors.forename: Melek
authors.initials: M
authors.lastname: Hamidanoglu
authors.forename: Hasan
authors.initials: H
authors.lastname: Karsen
authors.forename: Sebnem
authors.initials: S
authors.lastname: Unlu
authors.forename: Hasan
authors.initials: H
authors.lastname: Bilinc
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D043303:Aryldialkylphosphatase / Q000378:metabolism*; D002265:Carboxylic Ester Hydrolases / Q000378:metabolism*; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010019:Osteomyelitis / Q000201:enzymology*; D018384:Oxidative Stress; D055815:Young Adult
chemical_list: D002265:Carboxylic Ester Hydrolases; C019734:arylesterase; D043303:Aryldialkylphosphatase