title: Palladium-catalyzed C(sp2)-H cyanation using tertiary amine derived isocyanide as a cyano source.
abstract: An unprecedented palladium-catalyzed cyanation of aromatic C-H bonds by using tertiary amine derived isocyanide as a novel cyano source was developed. Cu(TFA)(2) was used as a requisite stoichiometric oxidant. Mechanistic studies suggest that a tertiary carbon cation-based intermediate is involved following the C-N bond breakage.
authors.affiliation: State Key Laboratory of Respiratory Disease, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, 190 Kaiyuan Avenue, Guangzhou 510530, China.
authors.forename: Jiangling
authors.initials: J
authors.lastname: Peng
authors.forename: Jiaji
authors.initials: J
authors.lastname: Zhao
authors.forename: Ziwei
authors.initials: Z
authors.lastname: Hu
authors.forename: Dongdong
authors.initials: D
authors.lastname: Liang
authors.forename: Jinbo
authors.initials: J
authors.lastname: Huang
authors.forename: Qiang
authors.initials: Q
authors.lastname: Zhu
mesh_terms: D000588:Amines / Q000737:chemistry*; D002384:Catalysis; D015394:Molecular Structure; D009570:Nitriles / Q000737:chemistry*; D016877:Oxidants / Q000737:chemistry; D010165:Palladium / Q000737:chemistry*
chemical_list: D000588:Amines; D009570:Nitriles; D016877:Oxidants; D010165:Palladium