title: Lipid profiling of cancerous and benign gallbladder tissues by 1H NMR spectroscopy.
abstract: Qualitative and quantitative (1) H NMR analysis of lipid extracts of gallbladder tissue in chronic cholecystitis (CC, benign) (n = 14), xanthogranulomatous cholecystitis (XGC, intermediate) (n = 9) and gallbladder cancer (GBC, malignant) (n = 8) was carried out to understand the mechanisms involved in the transformation of benign gallbladder tissue to intermediate and malignant tissue. The results revealed alterations in various tissue lipid components in gallbladder in CC, XGC and GBC. The difference in the nature of lipid components in benign and malignant disease may aid in the identification of the biological pathways involved in the etiopathogenesis of GBC. This is the first study on lipid profiling of gallbladder tissue by (1) H NMR spectroscopy, and has possible implications for the development of future diagnostic approaches.
authors.affiliation: Centre of Biomedical Magnetic Resonance, Lucknow, India.
authors.forename: Kamaiah
authors.initials: K
authors.lastname: Jayalakshmi
authors.forename: Kanchan
authors.initials: K
authors.lastname: Sonkar
authors.forename: Anu
authors.initials: A
authors.lastname: Behari
authors.forename: Vinay K
authors.initials: VK
authors.lastname: Kapoor
authors.forename: Neeraj
authors.initials: N
authors.lastname: Sinha
mesh_terms: D002764:Cholecystitis / Q000378:metabolism; D002788:Cholesterol Esters / Q000378:metabolism; D005704:Gallbladder / Q000378:metabolism* / Q000473:pathology*; D005706:Gallbladder Neoplasms / Q000378:metabolism*; D006099:Granuloma / Q000378:metabolism; D006801:Humans; D050356:Lipid Metabolism; D009682:Magnetic Resonance Spectroscopy / Q000379:methods*; D009092:Mucous Membrane / Q000378:metabolism / Q000473:pathology; D010743:Phospholipids / Q000378:metabolism; D010955:Plasmalogens / Q000378:metabolism; D011522:Protons; D014280:Triglycerides / Q000378:metabolism; D014973:Xanthomatosis / Q000378:metabolism
chemical_list: D002788:Cholesterol Esters; D010743:Phospholipids; D010955:Plasmalogens; D011522:Protons; D014280:Triglycerides