title: Kluyveromyces lactis: a suitable yeast model to study cellular defense mechanisms against hypoxia-induced oxidative stress.
abstract: Studies about hypoxia-induced oxidative stress in human health disorders take advantage from the use of unicellular eukaryote models. A widely extended model is the fermentative yeast Saccharomyces cerevisiae. In this paper, we describe an overview of the molecular mechanisms induced by a decrease in oxygen availability and their interrelationship with the oxidative stress response in yeast. We focus on the differential characteristics between S. cerevisiae and the respiratory yeast Kluyveromyces lactis, a complementary emerging model, in reference to multicellular eukaryotes.
authors.affiliation: Departamento de Bioloxía Celular e Molecular, Facultade de Ciencias, Universidade da Coruña, Coruña, Spain.
authors.forename: M Isabel
authors.initials: MI
authors.lastname: González Siso
authors.forename: M Esperanza
authors.initials: ME
authors.lastname: Cerdán
mesh_terms: D000693:Anaerobiosis / Q000276:immunology; D000818:Animals; D002477:Cells / Q000276:immunology*; D006801:Humans; D007716:Kluyveromyces / Q000166:cytology* / Q000276:immunology*; D050296:Microbial Viability; D008954:Models, Biological; D018384:Oxidative Stress / Q000276:immunology*