title: Antitumor activity and structure-activity relationship of diterpenoids with a dehydroabietyl skeleton.
abstract: A series of novel diterpenoids including imines, amides and ureas with a dehydroabietyl skeleton were screened to hepatocellular carcinoma (SMMC-7721), lung cancer (A-549), glioma (C-6) and breast carcinoma (MCF-7) tumor cells by MTT method. Their antitumor activity and structure activity relationship were analyzed. Several of the title compounds such as I-2, I-10, I-6 and I-5, possess noticeable antitumor activity against SMMC-7721, A-549, C-6 and MCF-7 tumor cells, with lowest IC(50) values of 6.65, 0.75, 0.81 and 10.65μM, respectively. Based on the structure-activity relationship investigation, the three kinds of diterpenoids with a dehydroabietyl skeleton show high activity to SMMC-7721 cells. Imines derivatives exhibit broad spectrum and highly efficient activities to the selected four kinds of tumor cells.
authors.affiliation: Institute of Chemical Industry of Forestry Products, CAF, Key Lab. of Biomass Energy and Material, Jiangsu Province, National Engineering Lab. for Biomass Chemical Utilization; Key and Lab. on Forest Chemical Engineering, SFA, Nanjing 210042, China. rxping2001@163.com
authors.forename: Xiaoping
authors.initials: X
authors.lastname: Rao
authors.forename: Xiuzhi
authors.initials: X
authors.lastname: Huang
authors.forename: Ling
authors.initials: L
authors.lastname: He
authors.forename: Jie
authors.initials: J
authors.lastname: Song
authors.forename: Zhanqian
authors.initials: Z
authors.lastname: Song
authors.forename: Shibin
authors.initials: S
authors.lastname: Shang
mesh_terms: D045784:Abietanes / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D020650:Combinatorial Chemistry Techniques; D004305:Dose-Response Relationship, Drug; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D061986:MCF-7 Cells; D015394:Molecular Structure; D013329:Structure-Activity Relationship
chemical_list: D045784:Abietanes; D000970:Antineoplastic Agents