title: Epidemiology of small intestinal atresia in Europe: a register-based study.
abstract: BACKGROUND
  The epidemiology of congenital small intestinal atresia (SIA) has not been well studied. This study describes the presence of additional anomalies, pregnancy outcomes, total prevalence and association with maternal age in SIA cases in Europe.
  
  
  METHODS
  Cases of SIA delivered during January 1990 to December 2006 notified to 20 EUROCAT registers formed the population-based case series. Prevalence over time was estimated using multilevel Poisson regression, and heterogeneity between registers was evaluated from the random component of the intercept.
  
  
  RESULTS
  In total 1133 SIA cases were reported among 5126, 164 registered births. Of 1044 singleton cases, 215 (20.6%) cases were associated with a chromosomal anomaly. Of 829 singleton SIA cases with normal karyotype, 221 (26.7%) were associated with other structural anomalies. Considering cases with normal karyotype, the total prevalence per 10 000 births was 1.6 (95% CI 1.5 to 1.7) for SIA, 0.9 (95% CI 0.8 to 1.0) for duodenal atresia and 0.7 (95% CI 0.7 to 0.8) for jejunoileal atresia (JIA). There was no significant trend in SIA, duodenal atresia or JIA prevalence over time (RR=1.0, 95% credible interval (CrI): 1.0 to 1.0 for each), but SIA and duodenal atresia prevalence varied by geographical location (p=0.03 and p=0.04, respectively). There was weak evidence of an increased risk of SIA in mothers aged less than 20 years compared with mothers aged 20 to 29 years (RR=1.3, 95% CrI: 1.0 to 1.8).
  
  
  CONCLUSIONS
  This study found no evidence of a temporal trend in the prevalence of SIA, duodenal atresia or JIA, although SIA and duodenal atresia prevalence varied significantly between registers.
authors.affiliation: Institute of Health & Society, Newcastle University, Baddiley-Clark Building, Richardson Road, Newcastle upon Tyne, NE2 4AX, England, UK.
authors.forename: Kate E
authors.initials: KE
authors.lastname: Best
authors.forename: Peter W G
authors.initials: PW
authors.lastname: Tennant
authors.forename: Marie-Claude
authors.initials: MC
authors.lastname: Addor
authors.forename: Fabrizio
authors.initials: F
authors.lastname: Bianchi
authors.forename: Patricia
authors.initials: P
authors.lastname: Boyd
authors.forename: Elisa
authors.initials: E
authors.lastname: Calzolari
authors.forename: Carlos Matias
authors.initials: CM
authors.lastname: Dias
authors.forename: Berenice
authors.initials: B
authors.lastname: Doray
authors.forename: Elizabeth
authors.initials: E
authors.lastname: Draper
authors.forename: Ester
authors.initials: E
authors.lastname: Garne
authors.forename: Miriam
authors.initials: M
authors.lastname: Gatt
authors.forename: Ruth
authors.initials: R
authors.lastname: Greenlees
authors.forename: Martin
authors.initials: M
authors.lastname: Haeusler
authors.forename: Babak
authors.initials: B
authors.lastname: Khoshnood
authors.forename: Bob
authors.initials: B
authors.lastname: McDonnell
authors.forename: Carmel
authors.initials: C
authors.lastname: Mullaney
authors.forename: Vera
authors.initials: V
authors.lastname: Nelen
authors.forename: Hanitra
authors.initials: H
authors.lastname: Randrianaivo
authors.forename: Anke
authors.initials: A
authors.lastname: Rissmann
authors.forename: Joaquin
authors.initials: J
authors.lastname: Salvador
authors.forename: David
authors.initials: D
authors.lastname: Tucker
authors.forename: Diana
authors.initials: D
authors.lastname: Wellesly
authors.forename: Judith
authors.initials: J
authors.lastname: Rankin
mesh_terms: D004380:Duodenal Obstruction / Q000151:congenital; D005060:Europe / Q000453:epidemiology; D005260:Female; D006801:Humans; D007409:Intestinal Atresia / Q000453:epidemiology*; D007421:Intestine, Small / Q000002:abnormalities*; D008423:Maternal Age; D011247:Pregnancy; D011256:Pregnancy Outcome; D015995:Prevalence; D016016:Proportional Hazards Models; D012042:Registries