title: Resuscitation with polymerized human placenta hemoglobin attenuated hemorrhagic shock-induced lung injury.
abstract: This study was designed to investigate whether polymerized human placenta hemoglobin (PolyPHb) attenuated hemorrhagic shock-induced lung injury. A mean arterial pressure (MAP) of 30mmHg was maintained for 60 min. Then, all the rats were randomly resuscitated with hetastarch, whole blood, or PolyPHb. The result indicated that PolyPHb greatly improved the MAP and pulmonary function, and significantly reduced the release of inflammatory cytokines, histopathological changes, and pulmonary edema. Therefore, our findings suggest that PolyPHb could reduce pulmonary injury after hemorrhagic shock, and this effect was probably associated with the depressed inflammatory response.
authors.affiliation: Laboratory of Anesthesiology and Translational Neuroscience Center, West China Hospital, Sichuan University, Chengdu, China.
authors.forename: Tao
authors.initials: T
authors.lastname: Li
authors.forename: Zhenyu
authors.initials: Z
authors.lastname: Zhang
authors.forename: Wei
authors.initials: W
authors.lastname: Wu
authors.forename: Daqin
authors.initials: D
authors.lastname: Liao
authors.forename: Yanfang
authors.initials: Y
authors.lastname: Chen
authors.forename: Shen
authors.initials: S
authors.lastname: Li
authors.forename: Chengmin
authors.initials: C
authors.lastname: Yang
authors.forename: Xuewen
authors.initials: X
authors.lastname: Xu
authors.forename: Jin
authors.initials: J
authors.lastname: Liu
mesh_terms: D000818:Animals; D062186:Arterial Pressure / Q000187:drug effects; D016207:Cytokines / Q000378:metabolism; D005260:Female; D006454:Hemoglobins / Q000008:administration & dosage* / Q000138:chemical synthesis / Q000378:metabolism; D006801:Humans; D018836:Inflammation Mediators / Q000378:metabolism; D008168:Lung / Q000187:drug effects* / Q000276:immunology / Q000473:pathology; D055370:Lung Injury / Q000209:etiology / Q000276:immunology / Q000517:prevention & control*; D008297:Male; D010920:Placenta / Q000378:metabolism; D058105:Polymerization; D011247:Pregnancy; D011654:Pulmonary Edema / Q000209:etiology / Q000276:immunology / Q000517:prevention & control*; D051381:Rats; D017207:Rats, Sprague-Dawley; D012129:Respiratory Function Tests; D012151:Resuscitation; D012771:Shock, Hemorrhagic / Q000150:complications / Q000188:drug therapy* / Q000276:immunology
chemical_list: D016207:Cytokines; D006454:Hemoglobins; D018836:Inflammation Mediators