title: The coexistence of systemic lupus erythematosus and thyrotoxicosis: the diagnostic value of antihistone antibodies.
abstract: We report four female patients with Graves' disease with positive ANA antibodies and possibility for development of systemic lupus erythematosus. All four patients have been treated with antithyroid drugs. SLE symptoms have appeared from 4 to 12 months after the beginning of therapy with methysol in two of them. The third patient had no symptoms for SLE, but her ANA, anti-DNA, and antihistone antibodies had been positive at the time of the onset of thyrotoxicosis. The fourth patient had alopecia areata with positive ANA and antihistone antibodies.
authors.affiliation: Department of Clinical Immunology, University Hospital Alexandrovska, Sofia, Bulgaria.
authors.forename: Marta
authors.initials: M
authors.lastname: Baleva
authors.forename: Krasimir
authors.initials: K
authors.lastname: Nikolov
authors.forename: Emil
authors.initials: E
authors.lastname: Manov
authors.forename: Anastas
authors.initials: A
authors.lastname: Stoikov
authors.forename: Rebhat
authors.initials: R
authors.lastname: Shabani
authors.forename: Lyubomir
authors.initials: L
authors.lastname: Dourmishev
authors.forename: Milena
authors.initials: M
authors.lastname: Nikolova