title: The shoot apical meristem regulatory peptide CLV3 does not activate innate immunity.
abstract: The Arabidopsis thaliana leucine-rich repeat receptor kinase FLAGELLIN SENSING2 (FLS2) is required for the recognition of bacterial flagellin in innate immunity. Recently, FLS2 was proposed to act as a multispecific receptor recognizing unrelated exogenous and endogenous peptide ligands, including CLAVATA3 (CLV3), a key regulator of shoot meristem stem cell production. Here, we report experimental evidence demonstrating that FLS2 does not recognize CLV3 and that the shoot apical meristem is immune to bacteria independently of CLV3 perception.
authors.affiliation: The Sainsbury Laboratory, Norwich Research Park, Norwich NR4 7UH, United Kingdom.
authors.forename: Cécile
authors.initials: C
authors.lastname: Segonzac
authors.forename: Zachary L
authors.initials: ZL
authors.lastname: Nimchuk
authors.forename: Martina
authors.initials: M
authors.lastname: Beck
authors.forename: Paul T
authors.initials: PT
authors.lastname: Tarr
authors.forename: Silke
authors.initials: S
authors.lastname: Robatzek
authors.forename: Elliot M
authors.initials: EM
authors.lastname: Meyerowitz
authors.forename: Cyril
authors.initials: C
authors.lastname: Zipfel
mesh_terms: D017360:Arabidopsis / Q000235:genetics / Q000276:immunology* / Q000382:microbiology; D029681:Arabidopsis Proteins / Q000235:genetics / Q000276:immunology*; D004789:Enzyme Activation; D049452:Green Fluorescent Proteins / Q000378:metabolism; D054884:Host-Pathogen Interactions; D008024:Ligands; D018519:Meristem / Q000276:immunology / Q000378:metabolism* / Q000382:microbiology; D010935:Plant Diseases / Q000276:immunology / Q000382:microbiology; D057865:Plant Immunity; D018520:Plant Shoots / Q000276:immunology / Q000378:metabolism* / Q000382:microbiology; D030821:Plants, Genetically Modified / Q000235:genetics / Q000276:immunology / Q000382:microbiology; D011485:Protein Binding; D011494:Protein Kinases / Q000235:genetics / Q000276:immunology; D044224:Pseudomonas syringae / Q000276:immunology / Q000472:pathogenicity; D011956:Receptors, Cell Surface / Q000276:immunology / Q000378:metabolism
chemical_list: C118167:AT2G27250 protein, Arabidopsis; D029681:Arabidopsis Proteins; D008024:Ligands; D011956:Receptors, Cell Surface; D049452:Green Fluorescent Proteins; D011494:Protein Kinases; C411853:FLS2 protein, Arabidopsis