title: [Diabetes mellitus and osteoporosis. Insulin signaling and bone/glucose/energy metabolism].
abstract: Recently, we reported that insulin signaling in osteoblasts was a positive regulator of bone acquisition, but also of bone resorption. Interestingly, insulin signaling in osteoblasts activated osteocalcin embedded in bone ECM by stimulating resorption activity in osteoclast. It has been demonstrated that activated osteocalcin acts as hormone and regulates glucose metabolism through increasing insulin secretion from pancreas. The interaction of bone and glucose metabolism established by these studies will be important to a study of the two scientific fields in the future, particularly a clinical field.
authors.affiliation: Department of Medical Biochemistry, Faculty of Life Science, Kumamoto University, Japan.
authors.forename: Tatsuya
authors.initials: T
authors.lastname: Yoshizawa
mesh_terms: D000818:Animals; D048909:Diabetes Complications / Q000150:complications*; D004734:Energy Metabolism / Q000502:physiology*; D005947:Glucose / Q000378:metabolism*; D006801:Humans; D007328:Insulin / Q000378:metabolism; D010024:Osteoporosis / Q000378:metabolism*; D015398:Signal Transduction
chemical_list: D007328:Insulin; D005947:Glucose