title: [Results of a comparative clinical trial of the Russian Β - interferon-1b bioanalogue (infibeta)].
abstract: Results of annual comparative clinical research of the Russian biosimilar of beta-IFN - 1в at 122 patients with multiple sclerosis are presented. There were positive dynamics on EDSS scores in both groups (in the main group and group of control) in a year of treatment. There were positive dynamics in frequency of relapses in the main group (with 1.5 to 0.4 in a year) and in group of control (with 1.4 to 0.37 in a year). Positive dynamics according to MRI was also fixed in both groups. In both groups, good tolerability of the treatment was noted. This research didn't reveal essential distinctions on efficiency and safety parameters in both groups.
authors.forename: E V
authors.initials: EV
authors.lastname: Popova
authors.forename: A N
authors.initials: AN
authors.lastname: Boĭko
authors.forename: A V
authors.initials: AV
authors.lastname: Vasil'ev
authors.forename: M V
authors.initials: MV
authors.lastname: Davydovskaia
authors.forename: I A
authors.initials: IA
authors.lastname: Zavalishin
authors.forename: S V
authors.initials: SV
authors.lastname: Kotov
authors.forename: M V
authors.initials: MV
authors.lastname: Krotenkova
authors.forename: N V
authors.initials: NV
authors.lastname: Khachanova
authors.forename: S N
authors.initials: SN
authors.lastname: Sharanova
authors.forename: S G
authors.initials: SG
authors.lastname: Shchur
authors.forename: T I
authors.initials: TI
authors.lastname: Iakushina
mesh_terms: D000293:Adolescent; D000328:Adult; D005260:Female; D006801:Humans; D007155:Immunologic Factors / Q000627:therapeutic use*; D016899:Interferon-beta / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000188:drug therapy* / Q000503:physiopathology; D013810:Therapeutic Equivalency; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D007155:Immunologic Factors; D016899:Interferon-beta