title: [Correlation analysis of thrombin-activatable fibrinolysis inhibitor single nucleotide polymorphism with venous thromboembolism].
abstract: This study was aimed to explore the change of single nucleotide polymorphism (SNP) of thrombin-activatable fibrinolysis inhibitor (TAFI) and its correlation of 2 sites (505a/g, 1040c/t) in its gene-coding region with venous thromboembolism (VTE). The genotype distribution of TAFI in 80 patients with VTE and 80 normal controls was detected by allele-specific PCR. The results showed that the distribution of each genotype of 505a/g polymorphism was not significantly different between the VTE and control groups (P > 0.05). However, t allele frequency of 1040c/t in VTE group decreased significantly as compared with the control group (40% vs 53.75%, P < 0.05), mainly due to the decrease of the proportion of tt homozygous in VTE group. It is concluded that obvious relationship is found between the polymorphism of 1040c/t in TAFI gene and VTE patients. t allele genotype may paly a protective role in VTE. The polymorphism of TAFI 505a/g may be not associated with VTE.
authors.affiliation: Department of Hematollgy, Shanxi Medical University Second Hospital, Taiyuan, Shanxi Province, China.
authors.forename: Can
authors.initials: C
authors.lastname: Li
authors.forename: Li-Hong
authors.initials: LH
authors.lastname: Hou
authors.forename: Xiu-E
authors.initials: XE
authors.lastname: Liu
authors.forename: Can
authors.initials: C
authors.lastname: Huang
authors.forename: Xiao-Hua
authors.initials: XH
authors.lastname: Wei
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D025901:Carboxypeptidase B2 / Q000235:genetics*; D016022:Case-Control Studies; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D054556:Venous Thromboembolism / Q000235:genetics*
chemical_list: D025901:Carboxypeptidase B2