title: Hypoxia-selective DNA interstrand cross-link formation by two modified nucleosides.
abstract: The clean crossed code: Two nitroimidazole-modified thymidines 1 a and 1 b were synthesized and incorporated into DNA oligomers. The 350 nm photolysis of 1 a and 1 b generated a 5-(2'-deoxyuridinyl)methyl radical that induced DNA interstrand cross-links (ICL; see scheme). A higher ICL yield was observed under hypoxic conditions than under aerobic conditions.
authors.affiliation: Department of Chemistry and Biochemistry, University of Wisconsin-Milwaukee, 53211, USA.
authors.forename: Yunyan
authors.initials: Y
authors.lastname: Kuang
authors.forename: Huabing
authors.initials: H
authors.lastname: Sun
authors.forename: J Craig
authors.initials: JC
authors.lastname: Blain
authors.forename: Xiaohua
authors.initials: X
authors.lastname: Peng
mesh_terms: D020029:Base Pairing; D003432:Cross-Linking Reagents / Q000737:chemistry*; D004247:DNA / Q000737:chemistry*; D003857:Deoxyuridine / Q000031:analogs & derivatives* / Q000737:chemistry; D000860:Hypoxia; D015394:Molecular Structure; D009705:Nucleosides / Q000737:chemistry*; D010782:Photolysis; D013936:Thymidine / Q000737:chemistry*
chemical_list: C510308:5-(2'-deoxyuridinyl)methyl; D003432:Cross-Linking Reagents; D009705:Nucleosides; D004247:DNA; D013936:Thymidine; D003857:Deoxyuridine