title: Central actions of somatostatin-28 and oligosomatostatin agonists to prevent components of the endocrine, autonomic and visceral responses to stress through interaction with different somatostatin receptor subtypes.
abstract: Somatostatin was discovered four decades ago and since then its physiological role has been extensively investigated, first in relation with its inhibitory effect on growth hormone secretion but soon it expanded to extrapituitary actions influencing various stressresponsive systems. Somatostatin is expressed in distinct brain nuclei and binds to five somatostatin receptor subtypes which are also widely expressed in the brain with a distinct distribution pattern. The last few years witnessed the discovery of highly selective peptide somatostatin receptor agonists and antagonists representing valuable tools to delineate the respective pathways of somatostatin signaling. Here we review the centrally mediated actions of somatostatin and related selective somatostatin receptor subtype agonists to influence the endocrine, autonomic, and visceral components of the stress response and basal behavior as well as thermogenesis.
authors.affiliation: CURE: Digestive Diseases Research Center and Center for Neurovisceral Sciences & Women's Health, Digestive Diseases Division, David Geffen School of Medicine at UCLA and VA Greater Los Angeles Healthcare System, Los Angeles, California, USA.
authors.forename: Andreas
authors.initials: A
authors.lastname: Stengel
authors.forename: Jean
authors.initials: J
authors.lastname: Rivier
authors.forename: Yvette
authors.initials: Y
authors.lastname: Taché
mesh_terms: D000818:Animals; D001921:Brain / Q000378:metabolism; D006801:Humans; D017481:Receptors, Somatostatin / Q000378:metabolism*; D015398:Signal Transduction / Q000502:physiology; D013004:Somatostatin / Q000819:agonists* / Q000037:antagonists & inhibitors / Q000378:metabolism; D053561:Somatostatin-28 / Q000378:metabolism*; D013312:Stress, Physiological / Q000502:physiology
chemical_list: D017481:Receptors, Somatostatin; D013004:Somatostatin; D053561:Somatostatin-28