title: Variant on chromosome 9p is associated with left ventricular mass:  results from two cohorts of essential hypertensive individuals.
abstract: OBJECTIVE
  It is well known that among hypertensive patients, an increased left ventricular mass (LVM) is a powerful predictor of cardiovascular morbidity and mortality. However, the mechanisms underlying LVM in hypertension are not completely understood, as the absolute value of blood pressure and other risk factors associated do not predict alone a definite LVM progression. Recently, the 9p21 chromosomal region has been consistently associated with coronary heart disease.
  
  
  RESULTS
  We examined the association of 384 single nucleotide polymorphisms (SNPs) in the short arm of chromosome 9 with LVM in 821 hypertensive individuals from northern Italy. We identified a SNP (rs894379) in the intronic region of the centlein, centrosomal protein (CNTLN) gene on chromosome 9p22, whose minor allele G is associated with an increased LVM. We performed a follow-up validation analysis for the top SNP in 1038 hypertensive individuals from southern Italy. We then combined the results and found a nominal association for rs894379 (β  =  2.46, P  =  0.0026).
  
  
  CONCLUSIONS
  We describe a new variant associated with echocardiography LVM. This result, though it needs to be further investigated, may improve our understanding of the genetic determination of this prognostically relevant trait.
authors.affiliation: Department of Clinical Medicine and Prevention, San Gerardo Hospital, University of Milano-Bicocca, Milan, Italy.
authors.forename: Cristina
authors.initials: C
authors.lastname: Menni
authors.forename: Lucia
authors.initials: L
authors.lastname: Boffi
authors.forename: Francesca
authors.initials: F
authors.lastname: Cesana
authors.forename: Chiara
authors.initials: C
authors.lastname: Viviani Anselmi
authors.forename: Stefano
authors.initials: S
authors.lastname: Nava
authors.forename: Francesca
authors.initials: F
authors.lastname: Bertola
authors.forename: Anna M Di
authors.initials: AM
authors.lastname: Blasio
authors.forename: Roberta
authors.initials: R
authors.lastname: Roncarati
authors.forename: Valentina
authors.initials: V
authors.lastname: Trimarco
authors.forename: Marina
authors.initials: M
authors.lastname: Marino
authors.forename: Bruno
authors.initials: B
authors.lastname: Trimarco
authors.forename: Guido
authors.initials: G
authors.lastname: Grassi
authors.forename: Cristina
authors.initials: C
authors.lastname: Giannattasio
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Mancia
mesh_terms: D000328:Adult; D000368:Aged; D000483:Alleles; D018797:Cell Cycle Proteins / Q000235:genetics*; D002899:Chromosomes, Human, Pair 9 / Q000235:genetics*; D015331:Cohort Studies; D018450:Disease Progression; D005260:Female; D056726:Genetic Association Studies; D006801:Humans; D006973:Hypertension / Q000150:complications* / Q000235:genetics*; D017379:Hypertrophy, Left Ventricular / Q000150:complications* / Q000235:genetics*; D007438:Introns; D007558:Italy; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D011379:Prognosis
chemical_list: C579064:CNTLN protein, human; D018797:Cell Cycle Proteins