title: Sleep deprivation alters rat ventral prostate morphology, leading to glandular atrophy: a microscopic study contrasted with the hormonal assays.
abstract: We investigated the effect of 96 h paradoxical sleep deprivation (PSD) and 21-day sleep restriction (SR) on prostate morphology using stereological assays in male rats. After euthanasia, the rat ventral prostate was removed, weighed, and prepared for conventional light microscopy. Microscopic analysis of the prostate reveals that morphology of this gland was altered after 96 h of PSD and 21 days of SR, with the most important alterations occurring in the epithelium and stroma in the course of both procedures compared with the control group. Both 96 h PSD and 21-day SR rats showed lower serum testosterone and higher corticosterone levels than control rats. The significance of our result referring to the sleep deprivation was responsible for deep morphological alterations in ventral prostate tissue, like to castration microscopic modifications. This result is due to the marked alterations in hormonal status caused by PSD and SR.
authors.affiliation: Departamento de Nutrição, Universidade Federal de São Paulo-UNIFESP-EPM, Rua Marselhesa 630, Vila Clementino, 04020-620 São Paulo, SP, Brazil.
authors.forename: Daniel P
authors.initials: DP
authors.lastname: Venâncio
authors.forename: Monica L
authors.initials: ML
authors.lastname: Andersen
authors.forename: Patricia S L
authors.initials: PS
authors.lastname: Vilamaior
authors.forename: Fernanda C
authors.initials: FC
authors.lastname: Santos
authors.forename: Adriano
authors.initials: A
authors.lastname: Zager
authors.forename: Sérgio
authors.initials: S
authors.lastname: Tufik
authors.forename: Sebastião R
authors.initials: SR
authors.lastname: Taboga
authors.forename: Marco T
authors.initials: MT
authors.lastname: De Mello
mesh_terms: D000818:Animals; D001284:Atrophy; D001681:Biological Assay; D003345:Corticosterone / Q000097:blood*; D008297:Male; D011467:Prostate / Q000378:metabolism / Q000473:pathology*; D051381:Rats; D017208:Rats, Wistar; D012892:Sleep Deprivation / Q000097:blood* / Q000473:pathology*; D012895:Sleep, REM; D013194:Staining and Labeling; D013739:Testosterone / Q000097:blood*
chemical_list: D013739:Testosterone; D003345:Corticosterone