title: Comparison of semi-automatic volumetric VX2 hepatic tumor segmentation from cone beam CT and multi-detector CT with histology in rabbit models.
abstract: OBJECTIVE
  The purpose of this study was to compare tumor volume in a VX2 rabbit model as calculated using semiautomatic tumor segmentation from C-arm cone-beam computed tomography (CBCT) and multidetector computed tomography (MDCT) to the actual tumor volume.
  
  
  METHODS
  Twenty VX2 tumors in 20 adult male New Zealand rabbits (one tumor per rabbit) were imaged with CBCT (using an intra-arterial contrast medium injection) and MDCT (using an intravenous contrast injection). All tumor volumes were measured using semiautomatic three-dimensional volumetric segmentation software. The software uses a region-growing method using non-Euclidean radial basis functions. After imaging, the tumors were excised for pathologic volume measurement. The imaging-based tumor volume measurements were compared to the pathologic volumes using linear regression, with Pearson's test, and correlated using Bland-Altman analysis.
  
  
  RESULTS
  Average tumor volumes were 3.5 ± 1.6 cm(3) (range, 1.4-7.2 cm(3)) on pathology, 3.8 ± 1.6 cm(3) (range, 1.3-7.3 cm(3)) on CBCT, and 3.9 ± 1.6 (range, 1.8-7.5 cm(3)) on MDCT (P < .001). A strong correlation between volumes on pathology and CBCT and also with MDCT was observed (Pearson's correlation coefficient = 0.993 and 0.996, P < .001, for CBCT and MDCT, respectively). Bland-Altman analysis showed that MDCT tended to overestimate tumor volume, and there was stronger agreement for tumor volume between CBCT and pathology than with MDCT, possibly because of the intra-arterial contrast injection.
  
  
  CONCLUSIONS
  Tumor volume as measured using semiautomatic tumor segmentation software showed a strong correlation with the "real volume" measured on pathology. The segmentation software on CBCT and MDCT can be a useful tool for volumetric hepatic tumor assessment.
authors.affiliation: Russell H. Morgan Department of Radiology and Radiological Science, Division of Vascular and Interventional Radiology, Johns Hopkins Hospital, Baltimore, MD 21287, USA.
authors.forename: Olivier
authors.initials: O
authors.lastname: Pellerin
authors.forename: Mingde
authors.initials: M
authors.lastname: Lin
authors.forename: Nikhil
authors.initials: N
authors.lastname: Bhagat
authors.forename: Roberto
authors.initials: R
authors.lastname: Ardon
authors.forename: Benoit
authors.initials: B
authors.lastname: Mory
authors.forename: Jean-François
authors.initials: JF
authors.lastname: Geschwind
mesh_terms: D000818:Animals; D045744:Cell Line, Tumor; D054893:Cone-Beam Computed Tomography; D003287:Contrast Media / Q000008:administration & dosage; D016014:Linear Models; D008113:Liver Neoplasms / Q000000981:diagnostic imaging*; D008297:Male; D061330:Multidetector Computed Tomography; D011817:Rabbits; D012984:Software; D047368:Tumor Burden
chemical_list: D003287:Contrast Media