title: Association between insertion/deletion polymorphism in angiotensin-converting enzyme gene and acute lung injury/acute respiratory distress syndrome: a meta-analysis.
abstract: BACKGROUND
  A previous meta-analysis reported a positive association between an insertion/deletion (I/D) polymorphism in the angiotensin-converting enzyme gene (ACE) and the risk of acute lung injury (ALI)/acute respiratory distress syndrome (ARDS). Here, we updated this meta-analysis and additionally assessed the association of this polymorphism with ALI/ARDS mortality.
  
  
  METHODS
  We searched electronic databases through October 2011 for the terms "angiotensin-converting enzyme gene", "acute lung injury", and "acute respiratory distress syndrome," and reviewed all studies that reported the relationship of the I/D polymorphism in ACE with ALI/ARDS in humans. Seven studies met the inclusion criteria, comprising 532 ALI/ARDS patients, 3032 healthy controls, and 1432 patients without ALI/ARDS. We used three genetic models: the allele, dominant, and recessive models.
  
  
  RESULTS
  The ACE I/D polymorphism was not associated with susceptibility to ALI/ARDS for any genetic model. However, the ACE I/D polymorphism was associated with the mortality risk of ALI/ARDS in Asian subjects ( P(allele) < 0.0001, P(dominant) = 0.001, P(recessive) = 0.002). This finding remained significant after correction for multiple comparisons.
  
  
  CONCLUSIONS
  There is a possible association between the ACE I/D polymorphism genotype and the mortality risk of ALI/ARDS in Asians.
authors.affiliation: Department of Surgery, Hofstra North Shore-LIJ School of Medicine, 350 Community Drive, Manhasset, NY 11030, USA.
authors.forename: Akihisa
authors.initials: A
authors.lastname: Matsuda
authors.forename: Taro
authors.initials: T
authors.lastname: Kishi
authors.forename: Asha
authors.initials: A
authors.lastname: Jacob
authors.forename: Monowar
authors.initials: M
authors.lastname: Aziz
authors.forename: Ping
authors.initials: P
authors.lastname: Wang
mesh_terms: D055371:Acute Lung Injury / Q000235:genetics* / Q000401:mortality; D016022:Case-Control Studies; D017353:Gene Deletion; D006801:Humans; D016254:Mutagenesis, Insertional; D007703:Peptidyl-Dipeptidase A / Q000235:genetics*; D011110:Polymorphism, Genetic / Q000235:genetics*; D012128:Respiratory Distress Syndrome / Q000235:genetics* / Q000401:mortality; D012307:Risk Factors; D015996:Survival Rate
chemical_list: D007703:Peptidyl-Dipeptidase A