title: The efficacy of gabapentin versus stabilization splint in management of sleep bruxism.
abstract: OBJECTIVE
  This study aimed to determine if the use of gabapentin is more efficacious than a stabilization splint with regard to the intensity of masseter muscle contractions and/or sleep quality for patients experiencing sleep bruxism (SB).
  
  
  METHODS
  Twenty patients with SB participated in this clinical study. They were randomly divided into two treatment groups: stabilization splint group (n = 10) and gabapentin group (n = 10). The first polysomnographic examination was performed before the beginning of the experiment for all the participants. At the end of a 2-month period of stabilization splint therapy or gabapentin usage, a second polysomnographic recording was made.
  
  
  RESULTS
  Statistically significant reductions in the number of SB episodes per hour and per night, bruxism time index, total duration of SB episodes per night and number of SB episodes in stages NR I and NR II (p < 0.05) were observed in both groups after treatment. Both treatments significantly reduced the mean intensity of masseter muscle contractions during SB episodes. Moreover, the participants treated with gabapentin showed a significant improvement in total sleep time, slow wave sleep (stage III), and sleep efficiency (p < 0.05).
  
  
  CONCLUSIONS
  Gabapentin could be an effective treatment modality in SBs, especially in those with poor sleep quality.
authors.affiliation: Dental Research Center, School of Dentistry, Mashhad University of Medical Sciences, Mashhad, Iran.
authors.forename: Azam Sadat
authors.initials: AS
authors.lastname: Madani
authors.forename: Ebrahim
authors.initials: E
authors.lastname: Abdollahian
authors.forename: Hasan Azangoo
authors.initials: HA
authors.lastname: Khiavi
authors.forename: Mehrdad
authors.initials: M
authors.lastname: Radvar
authors.forename: Mohsen
authors.initials: M
authors.lastname: Foroughipour
authors.forename: Hadi
authors.initials: H
authors.lastname: Asadpour
authors.forename: Nadia
authors.initials: N
authors.lastname: Hasanzadeh
mesh_terms: D000293:Adolescent; D000328:Adult; D000588:Amines / Q000627:therapeutic use*; D016302:Centric Relation; D003509:Cyclohexanecarboxylic Acids / Q000627:therapeutic use*; D018691:Excitatory Amino Acid Antagonists / Q000627:therapeutic use*; D005260:Female; D005500:Follow-Up Studies; D000077206:Gabapentin; D006801:Humans; D008297:Male; D008406:Masseter Muscle / Q000187:drug effects; D008875:Middle Aged; D009119:Muscle Contraction / Q000187:drug effects; D017090:Occlusal Splints; D016382:Orthodontic Appliance Design; D017286:Polysomnography; D016037:Single-Blind Method; D012890:Sleep / Q000187:drug effects; D020186:Sleep Bruxism / Q000188:drug therapy / Q000628:therapy*; D012894:Sleep Stages / Q000187:drug effects; D016896:Treatment Outcome; D055815:Young Adult; D005680:gamma-Aminobutyric Acid / Q000627:therapeutic use*
chemical_list: D000588:Amines; D003509:Cyclohexanecarboxylic Acids; D018691:Excitatory Amino Acid Antagonists; D005680:gamma-Aminobutyric Acid; D000077206:Gabapentin