title: Regioselective multi-component synthesis of 1H-pyrazolo[3,4-d]pyrimidine-6(7H)-thiones.
abstract: A variety of pyrazolo[3,4-d]pyrimidine-6(7H)-thione derivatives were easily synthesized with a novel, simple, efficient, and regioselective method via three-component condensation reaction of 5-methyl-1H-pyrazol-3-amine, arylisothiocyanates, and aldehydes in the presence of catalytic amount of p-toluenesulfonic acid (p-TSA) in 1-butyl-3-methylimidazolium bromide ionic liquid with excellent yields and short reaction times.
authors.affiliation: Catalysis Division, Department of Chemistry, University of Isfahan, Isfahan 81746-73441, Iran.
authors.forename: Shirin
authors.initials: S
authors.lastname: Safaei
authors.forename: Iraj
authors.initials: I
authors.lastname: Mohammadpoor-Baltork
authors.forename: Ahmad Reza
authors.initials: AR
authors.lastname: Khosropour
authors.forename: Majid
authors.initials: M
authors.lastname: Moghadam
authors.forename: Shahram
authors.initials: S
authors.lastname: Tangestaninejad
authors.forename: Valiollah
authors.initials: V
authors.lastname: Mirkhani
mesh_terms: D002384:Catalysis; D060326:Chemistry Techniques, Synthetic; D052578:Ionic Liquids / Q000737:chemistry; D011720:Pyrazoles / Q000737:chemistry*; D013237:Stereoisomerism; D013379:Substrate Specificity; D013871:Thiones / Q000138:chemical synthesis* / Q000737:chemistry*; D014050:Toluene / Q000031:analogs & derivatives / Q000737:chemistry
chemical_list: D052578:Ionic Liquids; D011720:Pyrazoles; D013871:Thiones; D014050:Toluene; C031280:pyrazole; C065428:4-toluenesulfinic acid