title: Niosomes: novel sustained release nonionic stable vesicular systems--an overview.
abstract: Vesicular systems are novel means of delivering drug in controlled manner to enhance bioavailability and get therapeutic effect over a longer period of time. Niosomes are such hydrated vesicular systems containing nonionic surfactants along with cholesterol or other lipids delivering drug to targeted site which are non toxic, requiring less production cost, stable over a longer period of time in different conditions, so overcomes drawbacks of liposome. Present review describes history, all factors affecting niosome formulation, manufacturing conditions, characterization, stability, administration routes and also their comparison with liposome. This review also gives relevant information regarding various applications of niosomes in gene delivery, vaccine delivery, anticancer drug delivery, etc.
authors.affiliation: Amrutvahini College of Pharmacy, Sangamner-422608, Dist. Ahmednagar, Maharshtra, India. nitinbmahale@yahoo.com
authors.forename: N B
authors.initials: NB
authors.lastname: Mahale
authors.forename: P D
authors.initials: PD
authors.lastname: Thakkar
authors.forename: R G
authors.initials: RG
authors.lastname: Mali
authors.forename: D R
authors.initials: DR
authors.lastname: Walunj
authors.forename: S R
authors.initials: SR
authors.lastname: Chaudhari
mesh_terms: D060433:Administration, Ophthalmic; D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage; D000977:Antiparasitic Agents / Q000008:administration & dosage; D002784:Cholesterol / Q000737:chemistry; D003692:Delayed-Action Preparations / Q000737:chemistry* / Q000494:pharmacology; D004337:Drug Carriers / Q000737:chemistry*; D004355:Drug Stability; D018014:Gene Transfer Techniques; D006801:Humans; D006863:Hydrogen-Ion Concentration; D057927:Hydrophobic and Hydrophilic Interactions; D007896:Leishmaniasis / Q000188:drug therapy; D008081:Liposomes / Q000737:chemistry*; D058990:Molecular Targeted Therapy; D010455:Peptides / Q000008:administration & dosage; D055672:Static Electricity; D013501:Surface-Active Agents / Q000737:chemistry*; D014612:Vaccines / Q000008:administration & dosage
chemical_list: D000970:Antineoplastic Agents; D000977:Antiparasitic Agents; D003692:Delayed-Action Preparations; D004337:Drug Carriers; D008081:Liposomes; D010455:Peptides; D013501:Surface-Active Agents; D014612:Vaccines; D002784:Cholesterol