title: Interdigitating dendritic cell sarcoma of the liver and lung: a case report with morphohological and immunohistochemical features of tumor.
abstract: Interdigitating dendritic cell sarcoma is extremely rare neoplasm that mainly occurs in the lymph nodes. Only 45 cases have been reported in the literature to date. We report a case of this sarcoma arising from the liver and lung, a previosly unreported site for this neoplasm. An 19-year-old girl deteriorated rapidly after artificial abortion and died 4 weeks later. Autopsy showed markedly enlarged liver and lung with numerous nodules up to 0.5 centimeters in diameter. Microscopically, nodules was composed of large pleomorphic cells that were immunohistochemically positive for proteins S-100 and vimentin, some of them expressed positivity to fascin and CD 68, with a rich small CD3 positive T lymphocytic infiltrateite around them. Based of these findings, the present case was diagnosed as interdigitating dendritic cell sarcoma, a neoplasm that remains a diagnostic and clinical challenge, because it can mimic a wide variety of other malignant tumors and tumor-like lesions.
authors.affiliation: Institute of Pathology, University of Sarajevo, Čekaluša, Sarajevo, Bosnia and Herzegovina. svjetlana.radovic@mf.mf.unsa.ba
authors.forename: Svjetlana
authors.initials: S
authors.lastname: Radović
authors.forename: Mirsad
authors.initials: M
authors.lastname: Dorić
authors.forename: Hamza
authors.initials: H
authors.lastname: Zujo
authors.forename: Ajna
authors.initials: A
authors.lastname: Hukić
authors.forename: Suada
authors.initials: S
authors.lastname: Kuskunović
authors.forename: Mirsad
authors.initials: M
authors.lastname: Babić
authors.forename: Ivana
authors.initials: I
authors.lastname: Tomić
mesh_terms: D000028:Abortion, Induced; D054739:Dendritic Cell Sarcoma, Interdigitating / Q000150:complications / Q000473:pathology*; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D008113:Liver Neoplasms / Q000150:complications / Q000473:pathology*; D008175:Lung Neoplasms / Q000150:complications / Q000473:pathology*; D009378:Neoplasms, Multiple Primary / Q000150:complications / Q000473:pathology*; D011247:Pregnancy; D011252:Pregnancy Complications, Neoplastic / Q000473:pathology; D055815:Young Adult