title: Beneficial effects of Ankaferd Blood Stopper on dermal wound healing: an experimental study.
abstract: Ankaferd Blood Stopper(®) (ABS) is a folkloric medicinal plant extract used as a haemostatic agent in traditional Turkish medicine. The aim of this study was to investigate the efficacy of ABS on the healing of dermal wounds in a rat model. Twenty Wistar albino rats were divided into two groups. Standard full-thickness skin defects were created on the back of the rats. In the control group (group 1), dressings moisturised with saline were changed daily. In the study group (group 2), the wounds were cleaned daily with saline, Ankaferd solution was applied, then the wounds were covered with moisturised dressings. The contraction percentage of wound areas were calculated on the 3rd, 7th, 10th and 14th days using a planimetric programme. On day 14, the wound areas were excised for histopathological examination, inflammatory scoring and evaluation of collagen deposition. The study group was superior to the control group in terms of inflammatory scoring, type I/type III collagen ratio and wound contraction rates. ABS(®) may be used effectively and safely on full-thickness wounds as a natural product.
authors.affiliation: Department of General Surgery, Ankara Training and Research Hospital, Ankara, TurkeyDepartment of Pathology, Ankara Training and Research Hospital, Ankara, Turkey.
authors.forename: Cagri
authors.initials: C
authors.lastname: Akalin
authors.forename: Serdar
authors.initials: S
authors.lastname: Kuru
authors.forename: Aziz Mutlu
authors.initials: AM
authors.lastname: Barlas
authors.forename: Kemal
authors.initials: K
authors.lastname: Kismet
authors.forename: Bugra
authors.initials: B
authors.lastname: Kaptanoglu
authors.forename: Aydin
authors.initials: A
authors.lastname: Demir
authors.forename: Hesna Muzeyyen
authors.initials: HM
authors.lastname: Astarci
authors.forename: Huseyin
authors.initials: H
authors.lastname: Ustun
authors.forename: Ertugrul
authors.initials: E
authors.lastname: Ertas
mesh_terms: D000818:Animals; D024042:Collagen Type I / Q000032:analysis; D024043:Collagen Type II / Q000032:analysis; D003286:Contracture / Q000209:etiology; D008297:Male; D008519:Medicine, Traditional; D010936:Plant Extracts / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D012867:Skin / Q000737:chemistry / Q000293:injuries* / Q000473:pathology; D014416:Tunisia; D014945:Wound Healing / Q000187:drug effects*
chemical_list: D024042:Collagen Type I; D024043:Collagen Type II; D010936:Plant Extracts; C539751:ankaferd blood stopper