title: Nampt/Visfatin/PBEF: a functionally multi-faceted protein with a pivotal role in malignant tumors.
abstract: Nampt/Visfatin/PBEF is a primary, rate-limiting enzyme involved in NAD+ biosynthesis, which serves as a pivotal substance for proteins, and is required for cell growth, survival, DNA replication and repair and energy metabolism. Growing researches have elucidated that it is a pleiotropic protein that functions not only as an enzyme, but also as an adipocytokin, a growth factor, and a cytokine. Additionally, accumulated evidences indicate that Nampt is correlated to various malignant tumors, and complicated mechanisms are proposed to be involved in the carcinogenesis, progression, invasion and metastasis of it, including regulation of energy metabolism and genome instability, promotion of proliferation, angiogenesis, and tumor-promoting inflammation, resistance in cell death and avoidance of immune destruction. APO866 and CHS-828 are recognized inhibitors of Nampt, known to block the intracellular and extracellular NAD+ synthesis pathway. Both of them are currently in clinical trials for the treatment of various malignant tumors and have been shown to represent novel promising antitumor chemotherapeutic agents.
authors.affiliation: Department of Orthopedics, The Second Xiangya Hospital of Central South University, Changsha, China.
authors.forename: He
authors.initials: H
authors.lastname: Jieyu
authors.forename: Tu
authors.initials: T
authors.lastname: Chao
authors.forename: Li
authors.initials: L
authors.lastname: Mengjun
authors.forename: Wang
authors.initials: W
authors.lastname: Shalong
authors.forename: Guan
authors.initials: G
authors.lastname: Xiaomei
authors.forename: Lin
authors.initials: L
authors.lastname: Jianfeng
authors.forename: Li
authors.initials: L
authors.lastname: Zhihong
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000627:therapeutic use; D014408:Biomarkers, Tumor / Q000037:antagonists & inhibitors / Q000378:metabolism*; D004791:Enzyme Inhibitors / Q000627:therapeutic use; D006801:Humans; D058990:Molecular Targeted Therapy; D009369:Neoplasms / Q000188:drug therapy / Q000201:enzymology* / Q000473:pathology; D054409:Nicotinamide Phosphoribosyltransferase / Q000037:antagonists & inhibitors / Q000378:metabolism*; D015398:Signal Transduction / Q000187:drug effects
chemical_list: D000970:Antineoplastic Agents; D014408:Biomarkers, Tumor; D004791:Enzyme Inhibitors; D054409:Nicotinamide Phosphoribosyltransferase