title: [Identification of a novel HLA allele, HLA-B*35:03:07, by sequencing-based typing].
abstract: This study was purposed to analyze and identify a novel HLA allele in Chinese population. A new HLA-B allele which is closely related to HLA-B*35:03:01 was initially detected by PCR-SSOP, then DNA sequencing was performed to identify the difference between the novel allele and HLA-B*35:03:01 allele. The result showed that the sequence of the new allele was different from all other known sequence. It differs from the closest matching HLA-B*35:03:01 by a single substitution at position 387 C→G in exon 3, no resulting in amino acid change. It is concluded that this allele is a novel one and has been officially named B*35:03:07 by the WHO Nomenclature Committee.
authors.affiliation: HLA Laboratory, Blood Center of Shandong Province, Jinan, Shandong Province, China.
authors.forename: Pei-Cong
authors.initials: PC
authors.lastname: Zhai
authors.forename: Yan
authors.initials: Y
authors.lastname: Liu
authors.forename: Yi
authors.initials: Y
authors.lastname: Zhang
authors.forename: Xiang-Min
authors.initials: XM
authors.lastname: Nie
authors.forename: Yong-Hong
authors.initials: YH
authors.lastname: Song
authors.forename: Yun-Long
authors.initials: YL
authors.lastname: Zhuang
authors.forename: Chuan-Fu
authors.initials: CF
authors.lastname: Zhu
mesh_terms: D000483:Alleles; D044466:Asian People / Q000235:genetics; D015235:HLA-B Antigens / Q000235:genetics*; D006801:Humans; D008297:Male; D017422:Sequence Analysis, DNA
chemical_list: D015235:HLA-B Antigens