title: Synthesis, characterization and evaluation of thiolated tamarind seed polysaccharide as a mucoadhesive polymer.
abstract: In the present study, thiol-functionalization of tamarind seed polysaccharide was carried out by esterification with thioglycolic acid. Thiol-functionalization was confirmed by SH stretch in Fourier-transformed infra-red spectra at 2586 cm(-1). It was found to possess 104.5 mM of thiol groups per gram. The results of differential scanning calorimetry and X-ray diffraction study indicate increase in crystallinity. Polymer compacts of thiolated tamarind seed polysaccharide required 6.85-fold greater force to detach from the mucin coated membrane than that of tamarind seed polysaccharide. Comparative evaluation of Carbopol-based metronidazole gels containing thiolated tamarind seed polysaccharide with gels containing tamarind seed polysaccharide for mucoadhesive strength using chicken ileum by modified balance method revealed higher mucoadhesion of gels containing thiolated tamarind seed polysaccharide. Further, the gels containing tamarind seed polysaccharide and thiolated tamarind seed polysaccharide released the drug by Fickian-diffusion following the first-order and Higuchi's-square root release kinetics, respectively.
authors.affiliation: Nanomaterials Synthesis & Characterization Laboratory, Department of Bio & Nano Technology, Guru Jambheshwar University of Science & Technology, Hisar 125001, India.
authors.forename: Harmanmeet
authors.initials: H
authors.lastname: Kaur
authors.forename: Shikha
authors.initials: S
authors.lastname: Yadav
authors.forename: Munish
authors.initials: M
authors.lastname: Ahuja
authors.forename: Neeraj
authors.initials: N
authors.lastname: Dilbaghi
mesh_terms: D000180:Acrylic Resins; D000269:Adhesives / Q000138:chemical synthesis* / Q000494:pharmacology; D005782:Gels; D007700:Kinetics; D008795:Metronidazole / Q000737:chemistry; D011108:Polymers / Q000138:chemical synthesis* / Q000494:pharmacology; D011134:Polysaccharides / Q000138:chemical synthesis* / Q000494:pharmacology; D011145:Polyvinyls / Q000737:chemistry; D012639:Seeds / Q000737:chemistry*; D013438:Sulfhydryl Compounds / Q000737:chemistry*; D029861:Tamarindus / Q000737:chemistry*; D014961:X-Ray Diffraction
chemical_list: D000180:Acrylic Resins; D000269:Adhesives; D005782:Gels; D011108:Polymers; D011134:Polysaccharides; D011145:Polyvinyls; D013438:Sulfhydryl Compounds; C006912:carboxypolymethylene; D008795:Metronidazole