title: Analysis of the absence of the detrusor muscle in initial transurethral resected specimens and the presence of residual tumor tissue.
abstract: OBJECTIVE
  To investigate the relationship between surgeon's experience, tumor characteristics, absent detrusor muscle (DM) tissue in resected specimens, and residual tumor after an initial transurethral resection.
  
  
  METHODS
  We conducted an analysis of 216 patients from two centers over a 3-year period. Patients with primary bladder tumors that were judged to have been completely resected were recruited. The data included tumor characteristics, surgeon category, and DM status. Logistic regression multivariate analyses were conducted.
  
  
  RESULTS
  Large tumors, lateral/dome/anterior wall tumors, and surgery performed by junior surgeons were independently associated with absent DM. Large tumors, dome/anterior wall tumors, T1 and absent DM were independently associated with residual disease. The absence and presence of the DM were associated with residual tumor rates of 51.8 and 20.9%, respectively (OR 15.537). Resection by senior surgeons was associated with the presence of DM and clean resection (OR 0.274 and 0.141, respectively).
  
  
  CONCLUSIONS
  Absent DM and residual tumor were more likely to occur in cases involving large tumors that were located in the lateral/dome/anterior wall, especially when the surgery was performed by a junior surgeon. Absent DM appears to be a surrogate marker for residual disease.
authors.affiliation: Department of Urology, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China.
authors.forename: Jiefu
authors.initials: J
authors.lastname: Huang
authors.forename: Jinggao
authors.initials: J
authors.lastname: Fu
authors.forename: Hailun
authors.initials: H
authors.lastname: Zhan
authors.forename: Keji
authors.initials: K
authors.lastname: Xie
authors.forename: Bolong
authors.initials: B
authors.lastname: Liu
authors.forename: Fei
authors.initials: F
authors.lastname: Yang
authors.forename: Yangbo
authors.initials: Y
authors.lastname: Lu
authors.forename: Xiangfu
authors.initials: X
authors.lastname: Zhou
mesh_terms: D000368:Aged; D005260:Female; D006801:Humans; D008297:Male; D008495:Medical Oncology / Q000379:methods; D008875:Middle Aged; D015999:Multivariate Analysis; D009130:Muscle, Smooth / Q000473:pathology* / Q000601:surgery*; D018365:Neoplasm, Residual; D016017:Odds Ratio; D015203:Reproducibility of Results; D016896:Treatment Outcome; D014521:Urethra / Q000473:pathology*; D001749:Urinary Bladder Neoplasms / Q000601:surgery* / Q000628:therapy; D014572:Urology / Q000379:methods