title: Metal-free N-H insertions of donor/acceptor carbenes.
abstract: Synthetically useful transformations arise from the thermal decomposition of aryldiazoacetates in the presence of primary and secondary amines without the use of a metal catalyst. Thermally generated, free donor/acceptor carbenes directly undergo N-H insertion with amines through selective aza-ylide formation to afford a variety of α-amino esters in 53-96% yields.
authors.affiliation: Emory University, Department of Chemistry, 1515 Dickey Drive, Atlanta, Georgia 30322, USA.
authors.forename: Stephanie R
authors.initials: SR
authors.lastname: Hansen
authors.forename: Jillian E
authors.initials: JE
authors.lastname: Spangler
authors.forename: Jørn H
authors.initials: JH
authors.lastname: Hansen
authors.forename: Huw M L
authors.initials: HM
authors.lastname: Davies