title: LIS1 clamps dynein to the microtubule.
abstract: Cytoplasmic dynein is a motor essential for numerous mechanical processes in eukaryotic cells. How its activity is regulated is largely unknown. By using a combination of approaches including single-molecule biophysics and electron microscopy, Huang et al. in this issue uncover the regulatory mechanism by which LIS1 controls the activity of cytoplasmic dynein.
authors.forename: Martina
authors.initials: M
authors.lastname: Trokter
authors.forename: Thomas
authors.initials: T
authors.lastname: Surrey