title: Chronic myeloid leukemia presenting with bilateral central retinal vein occlusion and massive retinal infiltrates.
abstract: Visual impairment as the initial symptom of leukemia, especially chronic myeloid leukemia, is rare, occurring in approximately 3% of all leukemias in children. We describe the case of a 14-year-old boy with vision loss attributable to bilateral central retinal vein occlusion and massive retinal infiltrates. Bone marrow biopsy demonstrated the BCR-ABL translocation, and the patient was diagnosed with chronic myeloid leukemia. A major cytogenetic remission was achieved 6 months after initiation of therapy.
authors.affiliation: Guru Nanak Eye Centre, Maulana Azad Medical College, New Delhi, India. nehadoc@hotmail.com
authors.forename: Neha
authors.initials: N
authors.lastname: Goel
authors.forename: Bhanu
authors.initials: B
authors.lastname: Pangtey
authors.forename: Meenakshi
authors.initials: M
authors.lastname: Thakar
authors.forename: Usha Kaul
authors.initials: UK
authors.lastname: Raina
authors.forename: Basudeb
authors.initials: B
authors.lastname: Ghosh
mesh_terms: D000293:Adolescent; D000493:Allopurinol / Q000627:therapeutic use; D000970:Antineoplastic Agents / Q000627:therapeutic use; D001549:Benzamides; D001853:Bone Marrow / Q000378:metabolism; D004359:Drug Therapy, Combination; D006801:Humans; D006918:Hydroxyurea / Q000627:therapeutic use; D000068877:Imatinib Mesylate; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000175:diagnosis* / Q000188:drug therapy; D017254:Leukemic Infiltration / Q000175:diagnosis* / Q000188:drug therapy; D008297:Male; D010879:Piperazines / Q000627:therapeutic use; D051562:Proto-Oncogene Proteins c-bcr / Q000378:metabolism; D011743:Pyrimidines / Q000627:therapeutic use; D012160:Retina / Q000473:pathology*; D019572:Retinal Neoplasms / Q000175:diagnosis* / Q000188:drug therapy; D012170:Retinal Vein Occlusion / Q000175:diagnosis* / Q000188:drug therapy; D014786:Vision Disorders / Q000175:diagnosis; D014792:Visual Acuity
chemical_list: D000970:Antineoplastic Agents; D001549:Benzamides; D010879:Piperazines; D011743:Pyrimidines; D000493:Allopurinol; D000068877:Imatinib Mesylate; D051562:Proto-Oncogene Proteins c-bcr; D006918:Hydroxyurea