title: Antagonizing the innate pattern recognition receptor CD204 to improve dendritic cell-targeted cancer immunotherapy.
abstract: Extensive studies have established a role of scavenger receptor CD204 in pattern recognition and ligand uptake. Strikingly, we recently revealed a previously unrecognized feature of CD204 action in attenuating T-cell activation and antitumor immunity. Blocking its activity in dendritic cells represents a promising approach to the improvement of cancer immunotherapy.
authors.affiliation: Department of Human and Molecular Genetics; Virginia Commonwealth University School of Medicine; Richmond, VA USA ; VCU Institute of Molecular Medicine; Virginia Commonwealth University School of Medicine; Richmond, VA USA ; VCU Massey Cancer Center; Virginia Commonwealth University School of Medicine; Richmond, VA USA.
authors.forename: Xiaofei
authors.initials: X
authors.lastname: Yu
authors.forename: Xiang-Yang
authors.initials: XY
authors.lastname: Wang