title: Deregulation of MTDH gene expression in gastric cancer.
abstract: OBJECTIVE
  Gastric cancer is the third most frequent cause of cancer mortality worldwide. In Iran, it is one of the leading causes at the national level. Localized at chromosome 8q22, the human MTDH gene has been reported to be over-expressed in a spectrum of malignancies. However, since there is a lack of data concerning with expression in gastric cancer at the transcriptional level, in this study we evaluated MTDH expression in Iranian cases.
  
  
  METHODS
  Totally, thirty paired gastric samples were examined by quantitative real-time RT-PCR.
  
  
  RESULTS
  Although the mRNA expression was significantly elevated in 46.6% of the examined tumor tissues; its expression was low in others (36.6%). Moreover, there was only a marginal statistical difference between the MTDH gene expression of all tumor specimens compared to their paired non-tumor ones and no statistically significant association with the grades and types of the tumors.
  
  
  CONCLUSIONS
  Taken together, our results demonstrated that expression of MTDH at the transcriptional level may be increased in gastric cancer tissue samples but with considerable heterogeneity. Due to this, it may have the potential to be used as a target for diagnostic/therapeutic purposes only in a subset of patients.
authors.affiliation: Department of Genetics, Faculty of Basic Sciences, Research Institute of Biotechnology, Shahrekord University, Shahrekord, Iran.
authors.forename: Modjtaba Emadi
authors.initials: ME
authors.lastname: Baygi
authors.forename: Parvaneh
authors.initials: P
authors.lastname: Nikpour
mesh_terms: D014408:Biomarkers, Tumor / Q000235:genetics / Q000378:metabolism; D015815:Cell Adhesion Molecules / Q000096:biosynthesis / Q000235:genetics*; D005753:Gastric Mucosa / Q000378:metabolism; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D007492:Iran; D008565:Membrane Proteins; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D016601:RNA-Binding Proteins; D013274:Stomach Neoplasms / Q000235:genetics* / Q000378:metabolism; D014158:Transcription, Genetic
chemical_list: D014408:Biomarkers, Tumor; D015815:Cell Adhesion Molecules; C483039:MTDH protein, human; D008565:Membrane Proteins; D012333:RNA, Messenger; D016601:RNA-Binding Proteins