title: [Clinical and angiographic outcomes of coronary drug-eluting stenting in treating vasospastic angina patients with severe organic stenosis].
abstract: OBJECTIVE
  To evaluate the clinical and angiographic outcomes of vasospastic angina patients with severe organic stenosis treated by drug-eluting stents.
  
  
  METHODS
  Between January 2006 and December 2010, severe organic stenosis (diameter stenosis more than 70%) was evidenced in 7 out of 46 vasospastic angina patients and treated with drug-eluting stents. Coronary angiography was repeated at 6 - 18 months after percutaneous coronary intervention and the patients were clinically followed up. The clinical and angiographic outcomes were observed.
  
  
  RESULTS
  Nine drug-eluting stents [mean diameter 2.75 - 3.50 (3.08 ± 0.24) mm, length 24 - 33 (27.3 ± 3.6) mm] were successfully implanted in these 7 patients. Stents were implanted into left anterior descending artery (LAD) in 5 patients (71.4%), right coronary artery (RCA) in 1 patient (14.3%), both LAD and RCA in 1 patient (14.3%). Transient RCA spasm and distal LAD spasm were observed during percutaneous coronary intervention of LAD in 2 patients. Anginal attack at rest with transient ST segment elevation at V(1)-V(3) leads occurred 24 hours after LAD stenting in 1 patient. Follow-up coronary angiography showed significant in-stent restenosis or focal edge restenosis (diameter stenosis more than 50%) in 3 patients (42.9%), mild neointimal proliferation but without significant restenosis in 2 patients (28.6%), and no neointimal proliferation in 2 patients (28.6%). During clinical follow-up of 17 to 50 months after percutaneous coronary intervention, 2 patients (28.6%) remained asymptomatic, while effort angina and/or rest angina was documented in the remaining 5 patients (71.4%).
  
  
  CONCLUSIONS
  Our results from this small patient cohort suggest that drug eluting stent implantation for severe organic stenosis in patients with vasospastic angina is linked with high incidence of restenosis and recurrent chest pain. Further observation in larger patient cohort is warranted to clarify the efficacy of this strategy for treating vasospastic angina patients with severe organic stenosis.
authors.affiliation: Department of Cardiology, Zhongshan Hospital, Fudan University, Shanghai Institute of Cardiovascular Diseases, Shanghai 200032, China.
authors.forename: Zhe-yong
authors.initials: ZY
authors.lastname: Huang
authors.forename: Ju-ying
authors.initials: JY
authors.lastname: Qian
authors.forename: Hong-bo
authors.initials: HB
authors.lastname: Yang
authors.forename: Lei
authors.initials: L
authors.lastname: Xu
authors.forename: Yu-xiang
authors.initials: YX
authors.lastname: Dai
authors.forename: Chen-guang
authors.initials: CG
authors.lastname: Li
authors.forename: Xin
authors.initials: X
authors.lastname: Zhong
authors.forename: Feng
authors.initials: F
authors.lastname: Zhang
authors.forename: Kang
authors.initials: K
authors.lastname: Yao
authors.forename: Jian-ying
authors.initials: JY
authors.lastname: Ma
authors.forename: Dong
authors.initials: D
authors.lastname: Huang
authors.forename: Xue-bo
authors.initials: XB
authors.lastname: Liu
authors.forename: Yan
authors.initials: Y
authors.lastname: Yan
authors.forename: Lei
authors.initials: L
authors.lastname: Ge
authors.forename: Bing
authors.initials: B
authors.lastname: Fan
authors.forename: Qi-bing
authors.initials: QB
authors.lastname: Wang
authors.forename: Jun-bo
authors.initials: JB
authors.lastname: Ge
mesh_terms: D000368:Aged; D000789:Angina, Unstable / Q000209:etiology / Q000628:therapy*; D015906:Angioplasty, Balloon, Coronary; D023921:Coronary Stenosis / Q000628:therapy*; D054855:Drug-Eluting Stents; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D016896:Treatment Outcome