title: Age-related histopathological changes in the cardiac conducting system in the Turkish population: an evaluation of 202 autopsy cases.
abstract: BACKGROUND
  Histopathological features of the cardiac conducting system (CCS) in the Turkish population have not been investigated previously.
  
  
  METHODS
  We examined CCS of 202 autopsy heart specimens dissected between the years 2004 and 2005 in Bursa Forensic Medicine Institution. Of the 202 cases from all age groups, 154 were males and 48 were females.
  
  
  RESULTS
  In our cases, an increase in fibrous and adipose tissue concordant with age, indicating an age-related nature, were detected. Fibrous and fatty tissue infiltration appeared at the age of 35. Fatty infiltration started between the ages 20 and 34 years at the sinoatrial node (SAN). There was no relationship between obesity and fatty tissue infiltration in SAN and atrioventricular node (AVN). In 4 cases calcification and in 19 cases inflammation was observed. Amyloid accumulation was not present. In 7 cases myocardial infarction not involving CCS was seen. In 1 case fibroelastoma was detected.
  
  
  CONCLUSIONS
  In the Turkish population age-related fibrosis and fatty infiltration in CCS appeared at the age of 35 years and increased with age. Fatty infiltration in the SAN started at a younger age than that reported in the literature. In cases where the cause of death could not be determined, we could not detect lethal pathological features. However, we think that examination of the CCS will improve the quality of autopsy diagnosis.
authors.affiliation: Department of Pathology, Near East University Faculty of Medicine, Nicosia, North Cyprus. cemcomunoglu@gmail.com
authors.forename: C
authors.initials: C
authors.lastname: Comunoglu
authors.forename: N
authors.initials: N
authors.lastname: Comunoglu
authors.forename: B
authors.initials: B
authors.lastname: Eren
authors.forename: O
authors.initials: O
authors.lastname: Tanrlöver
authors.forename: N
authors.initials: N
authors.lastname: Türkmen
authors.forename: U N
authors.initials: UN
authors.lastname: Gündogmuş
authors.forename: F
authors.initials: F
authors.lastname: Eren
mesh_terms: D000273:Adipose Tissue / Q000378:metabolism*; D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000473:pathology*; D001283:Atrioventricular Node / Q000473:pathology*; D001344:Autopsy; D002114:Calcinosis / Q000473:pathology*; D002648:Child; D002675:Child, Preschool; D005260:Female; D005355:Fibrosis; D006801:Humans; D008297:Male; D008875:Middle Aged; D012849:Sinoatrial Node / Q000473:pathology*; D014421:Turkey