title: Association of MTHFR 677T variant allele with risk of intracerebral haemorrhage: a meta-analysis.
abstract: BACKGROUND
  Previous studies concerning the association between methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism and risk of intracerebral haemorrhage (ICH) reported conflicting results. A meta-analysis of published studies was performed to allow a more reliable estimate of this association.
  
  
  METHODS
  Relevant studies concerning the association between MTHFR C677T polymorphism and risk of ICH were included into this meta-analysis. Odds ratios (OR) and 95% confidence intervals (CI) were determined for this gene-disease association using fixed or random effect models.
  
  
  RESULTS
  Finally, 16 studies with a total of 1828 cases and 4067 controls were included. Meta-analyses of a total of 16 studies showed that there was an obvious association of MTHFR 677T allele with risk of ICH under all four comparison models (OR(T vs. C)=1.38, 95% CI 1.17-1.62, P<0.001; OR(TT vs. CC)=1.90 95% CI 1.42-2.55, P<0.001; OR(TT vs. TC/CC)=1.38 95% CI 1.20-1.59, P<0.001; OR(TT/TC vs. CC)=1.41 95% CI 1.12-1.78, P=0.003). Besides, both subgroup analyses and sensitivity analysis further identified the association above.
  
  
  CONCLUSIONS
  The MTHFR 677T allele is associated with risk of ICH, and individuals with TT genotype have an obviously higher risk of ICH than those with the CC genotype.
authors.affiliation: Shanghai Neurologic Research Institute, Anhui Science & Technology University, Shanghai 201400, China.
authors.forename: Shan
authors.initials: S
authors.lastname: Gao
authors.forename: Hongzhao
authors.initials: H
authors.lastname: Li
authors.forename: Haijun
authors.initials: H
authors.lastname: Xiao
authors.forename: Guoxiang
authors.initials: G
authors.lastname: Yao
authors.forename: Yihai
authors.initials: Y
authors.lastname: Shi
authors.forename: Yongli
authors.initials: Y
authors.lastname: Wang
authors.forename: Xingsheng
authors.initials: X
authors.lastname: Zhou
authors.forename: Haifu
authors.initials: H
authors.lastname: Yu
mesh_terms: D000368:Aged; D000483:Alleles; D050197:Atherosclerosis / Q000453:epidemiology; D016022:Case-Control Studies; D002543:Cerebral Hemorrhage / Q000453:epidemiology* / Q000235:genetics; D015897:Comorbidity; D016001:Confidence Intervals; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D020138:Hyperhomocysteinemia / Q000453:epidemiology / Q000235:genetics; D006973:Hypertension / Q000453:epidemiology; D008297:Male; D042965:Methylenetetrahydrofolate Reductase (NADPH2) / Q000235:genetics*; D008875:Middle Aged; D008957:Models, Genetic; D016017:Odds Ratio; D020641:Polymorphism, Single Nucleotide; D012306:Risk
chemical_list: C573423:MTHFR protein, human; D042965:Methylenetetrahydrofolate Reductase (NADPH2)