title: Potential biomarkers for early detection of acute graft-versus-host disease.
abstract: Acute graft-versus-host disease (aGVHD) is the main complication of allogeneic hematopoietic stem cell transplantation (HCT), resulting in considerable morbidity and mortality. Currently, the diagnosis of aGVHD is largely made based on clinical parameters and invasive biopsies. For the past 20 years, researchers have been trying to find reliable biomarkers to enable early and accurate diagnosis of aGVHD. Although a number of potential aGVHD biomarkers have been published, as yet, no validated diagnostic test is available. Proteomics encompasses a broad range of rapidly developing technologies, which have shown tremendous promise for early detection of aGVHD. In this article, we review the current state of aGVHD biomarker discovery, provide a summary of the key proteins of interest and the most common analytical procedures for the clinic, as well as outlining the significant challenges faced in their use.
authors.affiliation: Core Facility-Proteomics, Central European Institute of Technology, Masaryk University, Brno, Czech Republic.
authors.forename: Gabriela
authors.initials: G
authors.lastname: Lochmanová
authors.forename: Lenka
authors.initials: L
authors.lastname: Jedličková
authors.forename: David
authors.initials: D
authors.lastname: Potěšil
authors.forename: Alexandra
authors.initials: A
authors.lastname: Tomancová
authors.forename: Jan
authors.initials: J
authors.lastname: Verner
authors.forename: Sárka
authors.initials: S
authors.lastname: Pospíšilová
authors.forename: Michael
authors.initials: M
authors.lastname: Doubek
authors.forename: Jiří
authors.initials: J
authors.lastname: Mayer
authors.forename: Zbyněk
authors.initials: Z
authors.lastname: Zdráhal
mesh_terms: D000208:Acute Disease; D015415:Biomarkers / Q000032:analysis*; D042241:Early Diagnosis; D006086:Graft vs Host Disease / Q000175:diagnosis* / Q000378:metabolism*; D006801:Humans; D040901:Proteomics; D013048:Specimen Handling
chemical_list: D015415:Biomarkers