title: Interpreting pharmacogenetic data in the developing neonate: the challenge of hitting a moving target.
abstract: In a 2010 review in Clinical Pharmacology & Therapeutics, Nick Holford noted that in neonates and young infants, maturation of the organs responsible for drug clearance is a more important determinant of pharmacokinetics (PK) than is body size.(1) Here we review recent developments that provide new insights into how physiological and environmental changes associated with adaptation to extrauterine life affect the ontogeny of drug biotransformation and interpretation of genotype-phenotype relationships in newborns and infants.
authors.affiliation: Department of Pediatrics, University of Missouri-Kansas City School of Medicine, Kansas City, Missouri, USA. sleeder@cmh.edu
authors.forename: J S
authors.initials: JS
authors.lastname: Leeder
authors.forename: G L
authors.initials: GL
authors.lastname: Kearns
mesh_terms: D000818:Animals; D001189:Aryl Hydrocarbon Hydroxylases / Q000235:genetics / Q000378:metabolism; D049628:Body Size / Q000187:drug effects / Q000502:physiology; D002657:Child Development / Q000187:drug effects / Q000502:physiology*; D065731:Cytochrome P-450 CYP2C19; D056726:Genetic Association Studies / Q000379:methods; D006801:Humans; D007231:Infant, Newborn; D008657:Metabolic Clearance Rate / Q000187:drug effects / Q000502:physiology; D004364:Pharmaceutical Preparations / Q000008:administration & dosage* / Q000378:metabolism; D010597:Pharmacogenetics / Q000379:methods*; D013223:Statistics as Topic / Q000379:methods*
chemical_list: D004364:Pharmaceutical Preparations; D001189:Aryl Hydrocarbon Hydroxylases; C045793:CYP2C19 protein, human; D065731:Cytochrome P-450 CYP2C19