title: Encapsulation of contrast imaging agents by polypropyleneimine-based dendrimers.
abstract: Polypropyleneimines (PPIs) functionalized by glycerol-based entities are prepared and characterized by diffusion-ordered spectroscopy NMR. Showing low cytotoxicity against MRC5 fibroblasts, their encapsulation capacities of gadolinium complexes was evaluated. T(1) measurements were performed to determine the relaxivity of the encapsulated gadopentetate dimeglumine (GdBOPTA) in dendrimers of fourth and fifth generation (GD-PPI-4 and GD-PPI-5). Comparison of the GdBOPTA relaxivity and the relaxivity of GdBOPTA-loaded dendrimers showed a slight increase of the gadolinium chelate relaxivity.
authors.affiliation: Institut de Chimie Moléculaire de Reims (ICMR), UMR CNRS No. 6229, UFR Sciences, Université Reims-Champagne-Ardenne, Reims, France.
authors.forename: S
authors.initials: S
authors.lastname: Balieu
authors.forename: C
authors.initials: C
authors.lastname: Cadiou
authors.forename: A
authors.initials: A
authors.lastname: Martinez
authors.forename: J-M
authors.initials: JM
authors.lastname: Nuzillard
authors.forename: J-B
authors.initials: JB
authors.lastname: Oudart
authors.forename: F-X
authors.initials: FX
authors.lastname: Maquart
authors.forename: F
authors.initials: F
authors.lastname: Chuburu
authors.forename: S
authors.initials: S
authors.lastname: Bouquillon
mesh_terms: D002460:Cell Line; D003287:Contrast Media / Q000737:chemistry* / Q000494:pharmacology; D050091:Dendrimers / Q000737:chemistry* / Q000494:pharmacology; D004353:Drug Evaluation, Preclinical; D005347:Fibroblasts / Q000166:cytology / Q000378:metabolism; D019786:Gadolinium DTPA / Q000737:chemistry* / Q000494:pharmacology; D006801:Humans; D011126:Polypropylenes / Q000737:chemistry* / Q000494:pharmacology
chemical_list: D003287:Contrast Media; D050091:Dendrimers; D011126:Polypropylenes; C443641:poly(propyleneimine); D019786:Gadolinium DTPA