title: Clinical observations and outcome of ventricular tachycardia ablation in patients with left ventricular assist devices.
abstract: BACKGROUND
  Ablation of ventricular tachycardia (VT) in patients with left ventricular assist devices (LVAD) is challenging and not well documented. This report describes our experience with endocardial VT ablation in six patients with an LVAD.
  
  
  METHODS
  We retrospectively reviewed the clinical records of LVAD patients who underwent an ablation procedure for refractory VT.
  
  
  RESULTS
  A total of eight ablation procedures were performed in six patients who, during the last 2 weeks before the ablation procedure, received a total of 101 appropriate shocks for VT. A closed aortic valve (n = 2) or aortic atheroma (n = 1) required a transseptal catheterization in three of six patients. The apical LVAD cannula served as a VT substrate in two of six patients. VT was eliminated in four patients and markedly reduced in two others. The latter two patients experienced a total of only four implantable cardioverter defibrillator (ICD) shocks during a follow-up of 130 and 493 days. Intravenous antiarrhythmic medications used in five of six patients before ablation were discontinued in all. The ablation procedures permitted hospital discharge in four of six patients. Five patients died during follow-up (228 ± 207 days after the procedure). The cause of death was unrelated to cardiac arrhythmias. One patient is still alive 1,205 days after the procedure.
  
  
  CONCLUSIONS
  Ablation of VT in LVAD patients is feasible and can result in a markedly decreased VT burden with a reduction of ICD shocks. The subsequent discontinuation of intravenous antiarrhythmic medications may facilitate hospital discharge.
authors.affiliation: Divisions of Cardiology Cardiothoracic Surgery Anesthesiology, Tampa General Hospital, Tampa, FL 33606, USA. bherweg@health.usf.edu
authors.forename: Bengt
authors.initials: B
authors.lastname: Herweg
authors.forename: Arzu
authors.initials: A
authors.lastname: Ilercil
authors.forename: Olga
authors.initials: O
authors.lastname: Kristof-Kuteyeva
authors.forename: Debbie
authors.initials: D
authors.lastname: Rinde-Hoffman
authors.forename: Christiano
authors.initials: C
authors.lastname: Caldeira
authors.forename: Devanand
authors.initials: D
authors.lastname: Mangar
authors.forename: Rachel
authors.initials: R
authors.lastname: Karlnosky
authors.forename: S Serge
authors.initials: SS
authors.lastname: Barold
mesh_terms: D000368:Aged; D005260:Female; D006353:Heart-Assist Devices; D006801:Humans; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D017180:Tachycardia, Ventricular / Q000150:complications* / Q000601:surgery*; D016896:Treatment Outcome; D018487:Ventricular Dysfunction, Left / Q000150:complications* / Q000517:prevention & control*