title: GLP-2 receptors in human disease: high expression in gastrointestinal stromal tumors and Crohn's disease.
abstract: Peptide hormones of the glucagon-like peptide (GLP) family play an increasing clinical role, as reported for GLP-1 in diabetes therapy and insulinoma diagnostics. GLP-2, despite its known trophic and anti-inflammatory intestinal actions translated into preliminary clinical studies using the GLP-2 analogue teduglutide for treatment of short bowel syndrome and Crohn's disease, remains poorly characterized in terms of expression of its receptor in tissues of interest. Therefore, the GLP-2 receptor expression was assessed in 237 tumor and 148 non-neoplastic tissue samples with in vitro receptor autoradiography. A GLP-2 receptor expression was present in 68% of gastrointestinal stromal tumors (GIST). Furthermore, GLP-2 receptors were identified in the intestinal myenteric plexus, with significant up-regulation in active Crohn's disease. The GLP-2 receptors in GIST may be used for clinical applications like in vivo targeting with radiolabelled GLP-2 analogues for imaging and therapy. Moreover, the over-expressed GLP-2 receptor in the myenteric plexus may represent the morphological correlate of the clinical target of teduglutide in Crohn's disease.
authors.affiliation: Division of Cell Biology and Experimental Cancer Research, Institute of Pathology, University of Berne, Berne, Switzerland. meike.koerner@pathology.unibe.ch
authors.forename: Meike
authors.initials: M
authors.lastname: Körner
authors.forename: Ruth
authors.initials: R
authors.lastname: Rehmann
authors.forename: Jean Claude
authors.initials: JC
authors.lastname: Reubi
mesh_terms: D000328:Adult; D000368:Aged; D001345:Autoradiography; D003424:Crohn Disease / Q000235:genetics* / Q000378:metabolism / Q000473:pathology; D005260:Female; D005770:Gastrointestinal Neoplasms / Q000235:genetics* / Q000378:metabolism / Q000473:pathology; D046152:Gastrointestinal Stromal Tumors / Q000235:genetics* / Q000378:metabolism / Q000473:pathology; D015870:Gene Expression; D053767:Glucagon-Like Peptide 2 / Q000378:metabolism*; D000067758:Glucagon-Like Peptide-2 Receptor; D006801:Humans; D007413:Intestinal Mucosa / Q000378:metabolism; D007422:Intestines / Q000473:pathology; D008875:Middle Aged; D009197:Myenteric Plexus / Q000378:metabolism / Q000473:pathology; D018027:Receptors, Glucagon / Q000235:genetics* / Q000378:metabolism; D015854:Up-Regulation
chemical_list: C578749:GLP2R protein, human; D053767:Glucagon-Like Peptide 2; D000067758:Glucagon-Like Peptide-2 Receptor; D018027:Receptors, Glucagon