title: Micronization of taxifolin by supercritical antisolvent process and evaluation of radical scavenging activity.
abstract: The aim of this study was to prepare micronized taxifolin powder using the supercritical antisolvent precipitation process to improve the dissolution rate of taxifolin. Ethanol was used as solvent and carbon dioxide was used as an antisolvent. The effects of process parameters, such as temperature (35-65 °C), pressure (10-25 MPa), solution flow rate (3-6 mL/min) and concentration of the liquid solution (5-20 mg/mL) on the precipitate crystals were investigated. With a lower temperature, a stronger pressure and a lower concentration of the liquid solution, the size of crystals decreased. The precipitation temperature, pressure and concentration of taxifolin solution had a significant effect. However, the solution flow rate had a negligible effect. It was concluded that the physicochemical properties and dissolution rate of crystalline taxifolin could be improved by physical modification such as particle size reduction using the supercritical antisolvent (SAS) process. Further, the SAS process was a powerful methodology for improving the physicochemical properties and radical scavenging activity of taxifolin.
authors.affiliation: State Engineering Laboratory for Bio-Resource Eco-Utilization, Northeast Forestry University, Harbin, 150040, China.
authors.forename: Shuchong
authors.initials: S
authors.lastname: Zu
authors.affiliation: State Engineering Laboratory for Bio-Resource Eco-Utilization, Northeast Forestry University, Harbin, 150040, China.
authors.forename: Lei
authors.initials: L
authors.lastname: Yang
authors.affiliation: State Engineering Laboratory for Bio-Resource Eco-Utilization, Northeast Forestry University, Harbin, 150040, China.
authors.forename: Jinming
authors.initials: J
authors.lastname: Huang
authors.affiliation: State Engineering Laboratory for Bio-Resource Eco-Utilization, Northeast Forestry University, Harbin, 150040, China.
authors.forename: Chunhui
authors.initials: C
authors.lastname: Ma
authors.affiliation: State Engineering Laboratory for Bio-Resource Eco-Utilization, Northeast Forestry University, Harbin, 150040, China.
authors.forename: Wenjie
authors.initials: W
authors.lastname: Wang
authors.affiliation: State Engineering Laboratory for Bio-Resource Eco-Utilization, Northeast Forestry University, Harbin, 150040, China.
authors.forename: Chunjian
authors.identifier: 0000-0003-2827-1999
authors.initials: C
authors.lastname: Zhao
authors.affiliation: State Engineering Laboratory for Bio-Resource Eco-Utilization, Northeast Forestry University, Harbin, 150040, China.
authors.forename: Yuangang
authors.initials: Y
authors.lastname: Zu
mesh_terms: D016166:Free Radical Scavengers / Q000737:chemistry*; D006358:Hot Temperature; D010316:Particle Size; D011794:Quercetin / Q000031:analogs & derivatives* / Q000737:chemistry
chemical_list: D016166:Free Radical Scavengers; D011794:Quercetin; C003377:taxifolin