title: Hepatitis B virus X protein plays an important role in gastric ulcers.
abstract: Hepatitis B virus (HBV) infects many individuals globally each year. Researchers             usually focus on the relationship between HBV and liver diseases. In this study,             we investigated the effects of HBV infection on gastric mucosa. We detected the             levels of HBX protein and mRNA in specimens from sixty-four chronic hepatitis             B patients (CHB) with gastric ulcers. We confirmed that HBX could aggravate gastric             ulcers according to clinicopathological parameters. In addition, we constructed             the pcDNA3.1-HBX plasmid and transfected it into GES-1, a gastric mucosal cell             line. The results indicated that HBX could induce apoptosis and G1 arrest in GES-1             cells. Insights into the mechanism of HBX action in GES-1 cells were obtained             using western blot analysis.
authors.affiliation: Department of Surgical Oncology, First Affiliated Hospital of China Medical University, Shenyang 110001, Liaoning, PR China.
authors.forename: Peng-Tao
authors.initials: PT
authors.lastname: Guo
authors.forename: Dong
authors.initials: D
authors.lastname: Yang
authors.forename: Zhe
authors.initials: Z
authors.lastname: Sun
authors.forename: Hui-Mian
authors.initials: HM
authors.lastname: Xu
mesh_terms: D017209:Apoptosis; D002460:Cell Line; D005260:Female; D059585:G1 Phase Cell Cycle Checkpoints; D005753:Gastric Mucosa / Q000166:cytology* / Q000378:metabolism / Q000821:virology*; D006509:Hepatitis B / Q000150:complications / Q000821:virology; D006515:Hepatitis B virus; D006801:Humans; D048031:JNK Mitogen-Activated Protein Kinases / Q000378:metabolism; D020935:MAP Kinase Signaling System; D008297:Male; D008875:Middle Aged; D012333:RNA, Messenger / Q000032:analysis / Q000235:genetics; D013276:Stomach Ulcer / Q000150:complications / Q000235:genetics / Q000821:virology*; D015534:Trans-Activators / Q000032:analysis / Q000235:genetics* / Q000378:metabolism*; D054334:Viral Regulatory and Accessory Proteins
chemical_list: D012333:RNA, Messenger; D015534:Trans-Activators; D054334:Viral Regulatory and Accessory Proteins; C057628:hepatitis B virus X protein; D048031:JNK Mitogen-Activated Protein Kinases