title: Exposure to bisphenol A results in a decline in mouse spermatogenesis.
abstract: Bisphenol A (BPA), a chemical used in many consumer products, interferes with the endocrine system of mammals, including humans. The aim of the present study was to investigate the effect of BPA on spermatogenesis and semen quality. The objective of this study was to assess the effects of BPA on mouse spermatogenesis. CD1 mice were used in all experiments. Mice were treated with different doses of BPA (0, 20 and 40 μg kg⁻¹ day⁻¹ from postnatal Day (PND) 3 to PND21, PND 35 or PND49. After 5 weeks BPA treatment, oestrogen receptor α expression was increased in mouse testis, whereas the meiotic progression of germ cells was slowed. Thus, both the quality and quantity of spermatozoa were decreased in 7-week-old mice. However, BPA had no effect on DNA methylation of imprinted genes such as Igf2, Igf2r, Peg3 and H19, in germ cells. In addition, exposure of male mice to BPA resulted in abnormal offspring that were smaller with a low-quality pelage when they were 35 days old. In conclusion, BPA hampers spermatogenesis and the subsequent development of offspring.
authors.affiliation: Key Laboratory of Animal Reproduction and Germplasm Enhancement in Universities of Shandong, Qingdao Agricultural University, Qingdao 266109, China.
authors.forename: Guo-Liang
authors.initials: GL
authors.lastname: Zhang
authors.forename: Xi-Feng
authors.initials: XF
authors.lastname: Zhang
authors.forename: Yan-Min
authors.initials: YM
authors.lastname: Feng
authors.forename: Lan
authors.initials: L
authors.lastname: Li
authors.forename: Evanna
authors.initials: E
authors.lastname: Huynh
authors.forename: Xiao-Feng
authors.initials: XF
authors.lastname: Sun
authors.forename: Zhong-Yi
authors.initials: ZY
authors.lastname: Sun
authors.forename: Wei
authors.initials: W
authors.lastname: Shen
mesh_terms: D000014:Abnormalities, Drug-Induced / Q000473:pathology; D000818:Animals; D000831:Animals, Newborn; D001559:Benzhydryl Compounds / Q000008:administration & dosage / Q000633:toxicity*; D001724:Birth Weight / Q000187:drug effects; D001835:Body Weight / Q000187:drug effects; D019175:DNA Methylation / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D052244:Endocrine Disruptors / Q000008:administration & dosage / Q000633:toxicity*; D047628:Estrogen Receptor alpha / Q000235:genetics / Q000378:metabolism; D004968:Estrogens, Non-Steroidal / Q000008:administration & dosage / Q000633:toxicity*; D018507:Gene Expression Regulation, Developmental / Q000187:drug effects; D007248:Infertility, Male / Q000139:chemically induced*; D007279:Injections, Subcutaneous; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D018812:Paternal Exposure / Q000009:adverse effects; D010636:Phenols / Q000008:administration & dosage / Q000633:toxicity*; D013091:Spermatogenesis / Q000187:drug effects*; D013094:Spermatozoa / Q000187:drug effects / Q000473:pathology; D013737:Testis / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology; D000098826:Bisphenol A Compounds
chemical_list: D001559:Benzhydryl Compounds; D052244:Endocrine Disruptors; D047628:Estrogen Receptor alpha; D004968:Estrogens, Non-Steroidal; D010636:Phenols; C006780:bisphenol A; D000098826:Bisphenol A Compounds