title: [Could antifungal lock be useful in the management of candidiasis linked with catheters?].
abstract: Fungal biofilms associated with inserted medical devices such as catheters, represent a major risk factor for candidemia. In addition, these biofilm yeasts show a decreased susceptibility to antifungal agents. Recently, a new therapeutic approach has emerged, the "lock therapy", based on the use of high concentrations of antimicrobials, instilled into the lumen of the catheter and left in place for 8 to 12 h. In vitro or in vivo studies have evaluated the interest of antifungal locks using amphotericin B, an azole or echinocandins. The promising results will permit us to discuss the relevance of this technique.
authors.affiliation: Laboratoire de parasitologie-mycologie médicale, université de Poitiers, UMR CNRS 6008, bâtiment urgence et biologie médicale (UBM), 2, rue de la Milétrie, 86021 Poitiers Cedex, France. estelle.cateau@chu-poitiers.fr
authors.forename: Estelle
authors.initials: E
authors.lastname: Cateau
authors.forename: Marie-Hélène
authors.initials: MH
authors.lastname: Rodier
authors.forename: Christine
authors.initials: C
authors.lastname: Imbert
mesh_terms: D000666:Amphotericin B / Q000008:administration & dosage / Q000627:therapeutic use; D000935:Antifungal Agents / Q000008:administration & dosage* / Q000627:therapeutic use; D018441:Biofilms / Q000187:drug effects*; D002175:Candida / Q000187:drug effects / Q000502:physiology; D058387:Candidemia / Q000188:drug therapy / Q000209:etiology / Q000517:prevention & control*; D000077336:Caspofungin; D055499:Catheter-Related Infections / Q000188:drug therapy* / Q000517:prevention & control*; D004305:Dose-Response Relationship, Drug; D025141:Drug Resistance, Fungal; D054714:Echinocandins / Q000008:administration & dosage / Q000627:therapeutic use; D006801:Humans; D055666:Lipopeptides / Q000008:administration & dosage / Q000627:therapeutic use; D000077551:Micafungin
chemical_list: D000935:Antifungal Agents; D054714:Echinocandins; D055666:Lipopeptides; C068538:liposomal amphotericin B; D000666:Amphotericin B; D000077336:Caspofungin; D000077551:Micafungin