title: Hematological effect of benzene exposure with emphasis of muconic acid as a biomarker.
abstract: Human exposure to benzene in work environment is a global occupational health problem. It is established that benzene requires to be metabolized to induce its effects. Benzene has been associated with various hematotoxins and carcinogens. The aim of this study was to investigate the effect of benzene on complete blood picture, with emphasis of trans, trans-muconic acid (t,t-MA) as a biomarker of benzene in urine, considering the influence of cigarette smoke. A total of 81 workers (61 males and 20 females) have been occupationally exposed to benzene. In addition, 83 workers (55males and 28 females) were also recruited as a control group. Complete blood picture was analyzed and urinary t,t-MA was determined by liquid chromatography. In addition, creatinine in the urine samples was determined. Levels of blood elements (white blood cells, red blood cells and platelets) were decreased among exposed workers compared with the controls. The urinary level of t,t-MA/creatinine of the exposed workers was elevated especially in the smoking group compared to the controls. This study recommends that complete blood picture and t,t-MA are helpful biomarker tests that should be done to detect the early effects of benzene exposure.
authors.affiliation: Environmental and Occupational Medicine Department, National Research Centre, Cairo, Egypt.
authors.forename: Khadiga S
authors.initials: KS
authors.lastname: Ibrahim
authors.affiliation: Environmental and Occupational Medicine Department, National Research Centre, Cairo, Egypt.
authors.forename: Nagat M
authors.initials: NM
authors.lastname: Amer
authors.affiliation: Environmental and Occupational Medicine Department, National Research Centre, Cairo, Egypt.
authors.forename: Elsaid A
authors.initials: EA
authors.lastname: El-dossuky
authors.affiliation: Industrial Medicine Department, Cairo University, Cairo, Egypt.
authors.forename: Ahmed M
authors.initials: AM
authors.lastname: Emara
authors.affiliation: Department of Chemistry, Faculty of Science, Cairo University, Cairo, Egypt.
authors.forename: Abd El-Samei M Abd
authors.initials: Ael-S
authors.lastname: El-Fattah
authors.affiliation: Environmental and Occupational Medicine Department, National Research Centre, Cairo, Egypt emshahy@yahoo.com.
authors.forename: Eman Mohamed
authors.initials: EM
authors.lastname: Shahy
mesh_terms: D001554:Benzene / Q000633:toxicity*; D015415:Biomarkers / Q000652:urine; D001772:Blood Cell Count; D016022:Case-Control Studies; D003404:Creatinine / Q000652:urine; D004906:Erythrocyte Count; D005260:Female; D006801:Humans; D007958:Leukocyte Count; D008297:Male; D066192:Manufacturing Industry; D016273:Occupational Exposure / Q000009:adverse effects*; D010976:Platelet Count; D012737:Sex Factors; D012907:Smoking / Q000009:adverse effects; D013011:Sorbic Acid / Q000031:analogs & derivatives* / Q000032:analysis
chemical_list: D015415:Biomarkers; C005939:muconic acid; D003404:Creatinine; D001554:Benzene; D013011:Sorbic Acid