title: [Allelic polymorphism of Pro582-->Ser HIF-1alpha to exercise-induced hypoxia adaptation].
abstract: The features of the distribution of allelic variants Pro582-->Ser polymorphism in HIF-1alpha gene in groups of athletes involved in sports, with different types of compensatory mechanisms of adaptation to hypoxic stress were investigated. During the study 191 highly qualified athletes were examined. The control group included 260 subjects, not engaged in sports. The possibility of using this polymorphism as a molecular genetic marker of susceptibility to a variety of sports pursuits. The distribution of allelic variants of HIF-1alpha Pro582-->Ser polymorphism of the residents of Ukraine was investigated. Found that the Pro/Pro genotype contributes to endurance performance. It is shown that the 582Ser gene HIF-1alpha is a marker of predisposition to power sports. The result revealed that the frequency of Ser allele of HIF-1alpha (16% vs 7%, P=0.03) was significantly higher in the power-orientated athletes compared to endurance athletes.
mesh_terms: D000222:Adaptation, Physiological / Q000235:genetics*; D000293:Adolescent; D000328:Adult; D000483:Alleles; D019943:Amino Acid Substitution; D015415:Biomarkers / Q000032:analysis; D015444:Exercise; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D000860:Hypoxia / Q000235:genetics*; D051795:Hypoxia-Inducible Factor 1, alpha Subunit / Q000235:genetics*; D008297:Male; D010807:Physical Endurance / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D013312:Stress, Physiological / Q000235:genetics; D014455:Ukraine
chemical_list: D015415:Biomarkers; C497442:HIF1A protein, human; D051795:Hypoxia-Inducible Factor 1, alpha Subunit