title: [Intralesional triamcinolone acetonide injection combined with conventional interventional modalities for the management of recalcitrant benign central airway stenosis: preliminary experience].
abstract: OBJECTIVE
  To evaluate the efficacy and security of local injection of triamcinolone acetonide (TA) combined multiple convention interventional procedures for benign central airway stenosis (BAS).
  
  
  METHODS
  Forty patients with intractable benign central airway restenosis after treated by repeatedly traditional interventional treatment in our hospital between January 2008 to December 2010 were retrospectively analyzed. Forty intractable BAS patients were selected and averagely divided into treatment group and control group. Local injection of TA was used to cover entire stenosis lesions. Two or more procedures were combined to manage complicated airway stenosis. After a 6 months follow-up, compared to before and after the treatment of airway diameter, airway stricture rate, dyspnea score, interphase of interventional treatment and clinical stabilization, fasting blood glucose, plasma cortisol, injection local mucosal and clinical symptoms, evaluated its curative effect and side effect.
  
  
  RESULTS
  Twenty cases of treatment group patients with intractable benign central airway stenosis were treated. After 6 to 18 months follow-up, 16 patients remain stable after treatment, besides 4 patients appear restenosis. 16 patients, did not appear restenosis; 4 patients appear restenosis. Restenosis interphase time or Clinical stationary time was increased from (10.95 ± 5.49) days before the therapy to (98.75 ± 55.58) days after therapy of local injection of TA (P < 0.01). The long-term outcome, the control group 20 cases restenosis in a 6 months follow-up time. After 6 months the the airway diameter of treatment group is (8.70 ± 2.52) mm compared with control group (4.50 ± 1.64) mm, (P < 0.01); the airway narrow rate of treatment group is (29.17 ± 14.55)%, compared with control group (64.80 ± 13.35)%, (P < 0.01); breathlessness score of treatment group is (0.55 ± 0.76), compared with control group (2.70 ± 0.92, P < 0.01), with statistically significant difference. None of the twenty patients appear local injections related complications, observation period, cortisol levels remain normal without glucocorticoids related serious complications.
  
  
  CONCLUSIONS
  Local injections of TA therapy combined with traditional interventional techniques for BAS has good curative effect and safety.
authors.affiliation: The First Affiliated Hospital of Guangzhou Medical College, Guangzhou Institute of Respiratory Diseases, State Key Laboratory of Respiratory Disease, Guangzhou 510120, China.
authors.forename: Yu
authors.initials: Y
authors.lastname: Chen
authors.forename: Hui-yi
authors.initials: HY
authors.lastname: Wu
authors.forename: Shi-yue
authors.initials: SY
authors.lastname: Li
mesh_terms: D000328:Adult; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D015552:Injections, Intralesional; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D014135:Tracheal Stenosis / Q000628:therapy*; D016896:Treatment Outcome; D014222:Triamcinolone Acetonide / Q000008:administration & dosage* / Q000009:adverse effects* / Q000627:therapeutic use; D055815:Young Adult
chemical_list: D014222:Triamcinolone Acetonide