title: [Anticoagulation and antiphospholipid syndrome: be careful to the catastrophe].
abstract: Antiphospholipid syndrome associate thromboembolic events (arterial or venous), and presence of antiphospholipid antibodies, and require anticoagulation. A catastrophic variant may develop, resulting in multiorgan failure, with high mortality rate. This article presented a patient with antiphospholipid syndrome presenting a catastrophic antiphospholipide syndrome after anticoagulation suspending for gastrointestinal bleeding. Multidisciplinary management in intensive care unit and aggressive therapies (corticosteroids, anticoagulation, plasma exchange) were essential to rescue the patient.
authors.affiliation: Service de médecine interne - médecine vasculaire, CHU Lyon-Sud, 165, chemin du Grand-Revoyet, 69495 Pierre-Bénite, France. caroline-lejeune@wanadoo.fr
authors.forename: C
authors.initials: C
authors.lastname: Le Jeune
authors.forename: P-E
authors.initials: PE
authors.lastname: Danin
authors.forename: J-C
authors.initials: JC
authors.lastname: Lega
authors.forename: J
authors.initials: J
authors.lastname: Bohe
authors.forename: V
authors.initials: V
authors.lastname: Piriou
mesh_terms: D000740:Anemia / Q000175:diagnosis / Q000601:surgery; D000925:Anticoagulants / Q000009:adverse effects*; D016736:Antiphospholipid Syndrome / Q000150:complications*; D001706:Biopsy; D002388:Catastrophic Illness; D006471:Gastrointestinal Hemorrhage / Q000150:complications; D006454:Hemoglobins / Q000378:metabolism; D006490:Hemostatics; D006493:Heparin / Q000627:therapeutic use; D006801:Humans; D008297:Male; D008875:Middle Aged; D010976:Platelet Count; D012131:Respiratory Insufficiency / Q000150:complications; D014812:Vitamin K / Q000037:antagonists & inhibitors
chemical_list: D000925:Anticoagulants; D006454:Hemoglobins; D006490:Hemostatics; D014812:Vitamin K; D006493:Heparin