title: Natural polymer-based magnetic hydrogels: Potential vectors for remote-controlled drug release.
abstract: The preparation and characterization of natural polymer-based hydrogels that contain 50-nm diameter magnetite (i.e., FeO:Fe(2)O(3)) nanoparticles are described herein. Fourier-transform infrared spectroscopy (FTIR) analysis confirmed the efficiency of the polysaccharide-modifying process. Thermogravimetric analysis (TGA), differential scanning calorimetry (DSC), and compressive moduli demostrate that the presence of magnetite improves thermal and mechanical resistance. Transient diffusion of water in magnetic hydrogels was analyzed via boundary layer mass transfer across an expaning interface, and the degree of swelling of these polysaccharide hydrogels decreases in the presence of magnetite, with no variation in the binary diffusion mechanism. The absence of hysteresis loops and coercivity observed via magnetometry suggests that magnetic hydrogels are useful for remote-controlled drug release, as demonstrated by magnetic-field-induced release of curcumin. Experiments reveal that magnetic hydrogels with greater magnetic susceptibility have the potential to release larger concentrations of drugs from the hydrogel network.
authors.affiliation: School of Chemical Engineering, Department of Chemical System Engineering, Separation Process Laboratory, State University of Campinas, Av. Albert Einstein, 500, Bloco A, Cidade Universitária, Campinas, SP 13083-852, Brazil. atpaulino10@gmail.com
authors.forename: Alexandre T
authors.initials: AT
authors.lastname: Paulino
authors.forename: Antonio G B
authors.initials: AG
authors.lastname: Pereira
authors.forename: André R
authors.initials: AR
authors.lastname: Fajardo
authors.forename: Kristin
authors.initials: K
authors.lastname: Erickson
authors.forename: Matt J
authors.initials: MJ
authors.lastname: Kipper
authors.forename: Edvani C
authors.initials: EC
authors.lastname: Muniz
authors.forename: Laurence A
authors.initials: LA
authors.lastname: Belfiore
authors.forename: Elias B
authors.initials: EB
authors.lastname: Tambourgi
mesh_terms: D003692:Delayed-Action Preparations / Q000737:chemistry*; D052203:Ferrosoferric Oxide / Q000737:chemistry*; D020100:Hydrogels / Q000737:chemistry*; D060526:Magnetic Fields; D011134:Polysaccharides / Q000737:chemistry*
chemical_list: D003692:Delayed-Action Preparations; D020100:Hydrogels; D011134:Polysaccharides; D052203:Ferrosoferric Oxide