title: Clinical features and imaging findings in pulmonary capillary hemangiomatosis: report of two cases and a pooled analysis.
abstract: BACKGROUND
  Pulmonary capillary hemangiomatosis (PCH) is a rare disease and no Chinese case has been reported yet. The disease is often misdiagnosed and its clinical characteristics are incompletely described. The aim of this study was to describe two Chinese cases and to clarify the clinical and radiographic parameters of patients with PCH.
  
  
  METHODS
  Two PCH cases were presented and other cases were searched from the English literature. All available clinical and radiographic data were collected from 62 literature reported PCH cases. A pooled analysis of total 64 cases was made.
  
  
  RESULTS
  Dyspnea and hemoptysis were the most common clinical symptoms of PCH. Pulmonary hypertension (PH) was found in 78% of the reported cases. PCH typically showed characteristic diffuse or patchy ground-glass opacities (GGOs) and/or multiple ill-defined centrilobular nodules in the computed tomography.
  
  
  CONCLUSIONS
  The diagnosis of PCH requires a high clinical suspicion. However, both clinical presentations and radiographic studies often provide clues to the diagnosis, which may prompt early lung biopsy for a definite diagnosis.
authors.affiliation: Department of Respiratory and Critical Care Medicine, Beijing Chao-Yang Hospital, Capital Medical University, Beijing 100020, China.
authors.forename: Wan-Mu
authors.initials: WM
authors.lastname: Xie
authors.forename: Hua-Ping
authors.initials: HP
authors.lastname: Dai
authors.forename: Mu-Lan
authors.initials: ML
authors.lastname: Jin
authors.forename: Zhen
authors.initials: Z
authors.lastname: Wang
authors.forename: Yuan-Hua
authors.initials: YH
authors.lastname: Yang
authors.forename: Zhen-Guo
authors.initials: ZG
authors.lastname: Zhai
authors.forename: Chen
authors.initials: C
authors.lastname: Wang
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D002675:Child, Preschool; D005260:Female; D018324:Hemangioma, Capillary / Q000150:complications / Q000175:diagnosis*; D006801:Humans; D008175:Lung Neoplasms / Q000150:complications / Q000175:diagnosis*; D008297:Male; D008875:Middle Aged; D014057:Tomography, X-Ray Computed