title: Netrin-1 in the developing enteric nervous system and colorectal cancer.
abstract: Netrin-1 is a well-characterised chemoattractant involved in neuronal guidance in the developing enteric nervous system (ENS), but it is also a regulator of tumorigenesis. Two of its well-characterised receptors, deleted in colorectal cancer (DCC) and uncoordinated-5 homolog (UNC-5H), belong to a family of dependence receptors that transmit either pro- or anti-apoptosis signals depending on the availability of ligand, in this case netrin-1. This review summarises these two effects of netrin-1 and highlights the additional research needed information about to allow better utilisation of netrin-1 as a therapeutic target for axonal regeneration in the context of colorectal cancer.
authors.affiliation: School of Biomedical and Health Sciences, Victoria University, St Albans 3021, Australia.
authors.forename: Suh Youn
authors.initials: SY
authors.lastname: Ko
authors.forename: Crispin R
authors.initials: CR
authors.lastname: Dass
authors.forename: Kulmira
authors.initials: K
authors.lastname: Nurgali
mesh_terms: D000818:Animals; D017209:Apoptosis; D002630:Chemotactic Factors / Q000378:metabolism*; D015179:Colorectal Neoplasms / Q000378:metabolism*; D017615:Enteric Nervous System / Q000196:embryology / Q000254:growth & development / Q000378:metabolism*; D006801:Humans; D009414:Nerve Growth Factors / Q000378:metabolism*; D000075388:Netrin-1; D015398:Signal Transduction; D025521:Tumor Suppressor Proteins / Q000378:metabolism*
chemical_list: D002630:Chemotactic Factors; C000617351:NTN1 protein, human; D009414:Nerve Growth Factors; D025521:Tumor Suppressor Proteins; D000075388:Netrin-1