title: Molecular features of sexual steroids on cartilage and bone.
abstract: In Brazil, the increase in the reported cases of degenerative diseases of articular cartilage is 20% per year, meaning that 200,000 Brazilians develop degenerative joint diseases every year, which have a negative impact on bone mass. This study shows evidence that hormone production of sexual steroids (estrogens, progestogens, and androgens) have an influence on cartilage quality, as well as on bone mass. Therefore, this review aimed to analyze literature data on the molecular and genic action of sexual steroids on hyaline cartilage and bone physiology, as well as osteoarthritis interference on the quality of these structures.
authors.affiliation: Universidade Federal de São Paulo, Brazil. robertawolff@uol.com.br
authors.forename: Roberta Bastos
authors.initials: RB
authors.lastname: Wolff
authors.forename: Regina Célia Teixeira
authors.initials: RC
authors.lastname: Gomes
authors.forename: Carina
authors.initials: C
authors.lastname: Verna
authors.forename: Gabriela Carolina C Cristofani
authors.initials: GC
authors.lastname: Maioral
authors.forename: Thaís Cristina
authors.initials: TC
authors.lastname: Rampazo
authors.forename: Ricardo Santos
authors.initials: RS
authors.lastname: Simões
authors.forename: Edmund Chada
authors.initials: EC
authors.lastname: Baracat
authors.forename: José Maria
authors.initials: JM
authors.lastname: Soares Júnior
mesh_terms: D000728:Androgens / Q000502:physiology*; D019902:Chondrocytes / Q000502:physiology; D020219:Chondrogenesis / Q000502:physiology*; D004967:Estrogens / Q000502:physiology*; D005260:Female; D006801:Humans; D008297:Male; D010003:Osteoarthritis / Q000503:physiopathology; D010006:Osteoblasts / Q000502:physiology; D010010:Osteoclasts / Q000502:physiology; D010012:Osteogenesis / Q000502:physiology*; D017698:Postmenopause; D011372:Progestins / Q000502:physiology*
chemical_list: D000728:Androgens; D004967:Estrogens; D011372:Progestins