title: Wound-dressing materials with antibacterial activity from electrospun polyurethane-dextran nanofiber mats containing ciprofloxacin HCl.
abstract: Dextran is a versatile biomacromolecule for preparing electrospun nanofibrous membranes by blending with either water-soluble bioactive agents or hydrophobic biodegradable polymers for biomedical applications. In this study, an antibacterial electrospun scaffold was prepared by electrospinning of a solution composed of dextran, polyurethane (PU) and ciprofloxacin HCl (CipHCl) drug. The obtained nanofiber mats have good morphology. The mats were characterized by various analytical techniques. The interaction parameters between fibroblasts and the PU-dextran and PU-dextran-drug scaffolds such as viability, proliferation, and attachment were investigated. The results indicated that the cells interacted favorably with the scaffolds especially the drug-containing one. Moreover, the composite mat showed good bactericidal activity against both of Gram-positive and Gram-negative bacteria. Overall, our results conclude that the introduced scaffold might be an ideal biomaterial for wound dressing applications.
authors.affiliation: Bionano Systems Engineering Department, Chonbuk National University, Jeonju, 561-756, Republic of Korea.
authors.forename: Afeesh R
authors.initials: AR
authors.lastname: Unnithan
authors.forename: Nasser A M
authors.initials: NA
authors.lastname: Barakat
authors.forename: P B Tirupathi
authors.initials: PB
authors.lastname: Pichiah
authors.forename: Gopalsamy
authors.initials: G
authors.lastname: Gnanasekaran
authors.forename: R
authors.initials: R
authors.lastname: Nirmala
authors.forename: Youn-Soo
authors.initials: YS
authors.lastname: Cha
authors.forename: Che-Hun
authors.initials: CH
authors.lastname: Jung
authors.forename: Mohamed
authors.initials: M
authors.lastname: El-Newehy
authors.forename: Hak Yong
authors.initials: HY
authors.lastname: Kim
mesh_terms: D041721:3T3-L1 Cells; D000818:Animals; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects*; D001458:Bandages; D001672:Biocompatible Materials / Q000737:chemistry / Q000494:pharmacology; D049109:Cell Proliferation / Q000187:drug effects; D002939:Ciprofloxacin / Q000737:chemistry*; D003911:Dextrans / Q000737:chemistry*; D004563:Electrochemistry; D005347:Fibroblasts / Q000166:cytology / Q000187:drug effects; D051379:Mice; D011108:Polymers / Q000737:chemistry / Q000494:pharmacology*; D011140:Polyurethanes / Q000737:chemistry*; D014945:Wound Healing / Q000187:drug effects
chemical_list: D000900:Anti-Bacterial Agents; D001672:Biocompatible Materials; D003911:Dextrans; D011108:Polymers; D011140:Polyurethanes; D002939:Ciprofloxacin