title: Down's syndrome and Alzheimer's disease: towards secondary prevention.
abstract: A public-private partnership to establish biomarkers of dementia in Down's syndrome could aid the development of preventive therapies for the dementia associated with both Down's syndrome and Alzheimer's disease, based on the apparent common pathogenic role of amyloid precursor protein in the two conditions.
authors.affiliation: Janssen Research & Development, 1125 Trenton-Harbourton Road, Raritan, New Jersey 08560, USA. sness@its.jnj.com
authors.forename: Seth
authors.initials: S
authors.lastname: Ness
authors.forename: Michael
authors.initials: M
authors.lastname: Rafii
authors.forename: Paul
authors.initials: P
authors.lastname: Aisen
authors.forename: Michael
authors.initials: M
authors.lastname: Krams
authors.forename: Wayne
authors.initials: W
authors.lastname: Silverman
authors.forename: Husseini
authors.initials: H
authors.lastname: Manji
mesh_terms: D000544:Alzheimer Disease / Q000209:etiology / Q000235:genetics / Q000517:prevention & control*; D016229:Amyloid beta-Peptides / Q000009:adverse effects / Q000235:genetics; D053327:Apolipoprotein E4 / Q000009:adverse effects / Q000235:genetics; D004314:Down Syndrome / Q000209:etiology / Q000235:genetics / Q000517:prevention & control*; D005819:Genetic Markers / Q000235:genetics; D005838:Genotype; D006801:Humans; D055502:Secondary Prevention / Q000379:methods
chemical_list: D016229:Amyloid beta-Peptides; D053327:Apolipoprotein E4; D005819:Genetic Markers