title: Mechanisms of anemia in CKD.
abstract: Anemia is a common feature of CKD associated with poor outcomes. The current management of patients with anemia in CKD is controversial, with recent clinical trials demonstrating increased morbidity and mortality related to erythropoiesis stimulating agents. Here, we examine recent insights into the molecular mechanisms underlying anemia of CKD. These insights hold promise for the development of new diagnostic tests and therapies that directly target the pathophysiologic processes underlying this form of anemia.
authors.affiliation: Massachusetts General Hospital, 185 Cambridge Street, Boston, MA 02114, USA. babitt.jodie@mgh.harvard.edu
authors.forename: Jodie L
authors.initials: JL
authors.lastname: Babitt
authors.forename: Herbert Y
authors.initials: HY
authors.lastname: Lin
mesh_terms: D000740:Anemia / Q000097:blood / Q000209:etiology* / Q000503:physiopathology; D018798:Anemia, Iron-Deficiency / Q000209:etiology; D023181:Antimicrobial Cationic Peptides / Q000378:metabolism; D004920:Erythropoiesis; D004921:Erythropoietin / Q000172:deficiency; D064451:Hepcidins; D006706:Homeostasis; D006801:Humans; D019266:Iron, Dietary / Q000493:pharmacokinetics; D008954:Models, Biological; D051436:Renal Insufficiency, Chronic / Q000097:blood / Q000150:complications* / Q000503:physiopathology
chemical_list: D023181:Antimicrobial Cationic Peptides; C554270:EPO protein, human; D064451:Hepcidins; D019266:Iron, Dietary; D004921:Erythropoietin