title: Synthesis and biological activities of new halophenols.
abstract: A series of new halophenols were synthesized, and their structures were established on the basis of 1H, 13C NMR and mass spectral data. All of the prepared compounds were screened for their in vitro protein tyrosine kinase (PTK) and vascular smooth muscle cell (VSMC) proliferation inhibitory activity. Twelve halophenols showed significant PTK inhibitory activity, most of them exhibited stronger activities than that of genistein, a positive reference compound. Several halophenols also displayed moderate VSMC proliferation inhibitory activity, compound 8c showed higher activity than that of tetrandrine, a positive reference compound. The preliminary structure-activity relationships of these compounds were investigated and discussed. The results provided a foundation for the action mechanism study and further structure optimization of the halophenols.
authors.affiliation: School of Pharmaceutical Science, Shanxi Medical University, Taiyuan 030001, Shanxi Province, PR China.
authors.forename: FeiLang
authors.initials: F
authors.lastname: Zheng
authors.forename: ShuRong
authors.initials: S
authors.lastname: Ban
authors.forename: XiuE
authors.initials: X
authors.lastname: Feng
authors.forename: ChengXiao
authors.initials: C
authors.lastname: Zhao
authors.forename: GuanHua
authors.initials: G
authors.lastname: Du
authors.forename: QingShan
authors.initials: Q
authors.lastname: Li
mesh_terms: D000818:Animals; D049109:Cell Proliferation / Q000187:drug effects; D060326:Chemistry Techniques, Synthetic; D005663:Furans / Q000737:chemistry; D054879:Halogenation; D020128:Inhibitory Concentration 50; D008297:Male; D051379:Mice; D009131:Muscle, Smooth, Vascular / Q000166:cytology; D010636:Phenols / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D047428:Protein Kinase Inhibitors / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D011505:Protein-Tyrosine Kinases / Q000037:antagonists & inhibitors; D051381:Rats; D013329:Structure-Activity Relationship
chemical_list: D005663:Furans; D010636:Phenols; D047428:Protein Kinase Inhibitors; D011505:Protein-Tyrosine Kinases