title: [Clinico-morphological and molecular-genetic characteristic of the miometrium with failure of the uterine scar after the Cesarean section at women with undifferentiated forms of connective tissue dysplasia].
abstract: Connective tissue state, its strength, is actual problem especially in the moment of labor because the weakness of labor activity or accelerated labor can be in depending on its consistency and elasticity. In addition, connective tissue is very important in the involution of the uterus after labor or wounds healing. Clinico-morphological and molecular-genetic investigation of 90 patients with undifferentiated forms of connective tissue dysplasia (uCTD) has been done. Reparation of tissue at patients with uCTD had a number of peculiarities, such as fibromuscular scar formation by substitution mechanisms with the laminin deficiency in the basic capillar membrane and extracellular matrix, accumulation of III and IV types of collagen, low expression of VEGF in the stromal cell and polymorphism of the alpha estrogen receptor gene. This immunohistochemical changes correlated with focuses of connective tissue disorganization as mucoid swelling, fibrinoid changes and hyalinosis, as well pathology of the microvasculature, resulted in chronic ischemia of the tissue. The disorganization is connected with disturbed reparation as a result of the genetically determined polymorphism of alpha and beta estrogen receptors. uCTD in pregnant women is prognostically significant for selection of way of delivery.
authors.forename: T A
authors.initials: TA
authors.lastname: Demura
authors.forename: E A
authors.initials: EA
authors.lastname: Kogan
authors.forename: A E
authors.initials: AE
authors.lastname: Donnikov
authors.forename: N E
authors.initials: NE
authors.lastname: Kan
authors.forename: M I
authors.initials: MI
authors.lastname: Kesova
authors.forename: A I
authors.initials: AI
authors.lastname: Martynov
authors.forename: O V
authors.initials: OV
authors.lastname: Bolotova
authors.forename: G T
authors.initials: GT
authors.lastname: Sukhikh
mesh_terms: D000328:Adult; D000599:Amino Acids, Diamino / Q000235:genetics / Q000378:metabolism; D002585:Cesarean Section / Q000009:adverse effects; D003094:Collagen / Q000235:genetics / Q000378:metabolism; D003238:Connective Tissue / Q000378:metabolism / Q000473:pathology; D005260:Female; D015870:Gene Expression; D056726:Genetic Association Studies; D005838:Genotype; D006801:Humans; D007150:Immunohistochemistry; D009154:Mutation; D009215:Myometrium / Q000378:metabolism / Q000473:pathology*; D011110:Polymorphism, Genetic; D011247:Pregnancy; D011248:Pregnancy Complications; D011960:Receptors, Estrogen / Q000235:genetics / Q000378:metabolism; D014599:Uterus / Q000378:metabolism / Q000473:pathology / Q000601:surgery; D042461:Vascular Endothelial Growth Factor A / Q000235:genetics / Q000378:metabolism
chemical_list: D000599:Amino Acids, Diamino; D011960:Receptors, Estrogen; D042461:Vascular Endothelial Growth Factor A; C045397:laminine; D003094:Collagen