title: Endogenous growth hormone and insulin after interposition of a reversed jejunal segment in short bowel syndrome. An experimental study on pigs.
abstract: BACKGROUND
  Interposition of a reversed jejunal loop in short bowel sydrome has previously been investigated in human along with animal models and seemed able to facilitate intestinal adaptation. However, it is unclear if growth hormone and insulin, well known for their implication in short bowel pathophysiology, intervene on this effect.
  
  
  RESULTS
  Porcine models were randomly allocated to two cohorts: (1) short bowel (SB) group (n = 8) and (2) short bowel reverse jejunal segment (SB-RS) group (n = 8). Amongst other parameters serum growth hormone and insulin were measured at baseline, as well as on postoperative day 30 and 60.
  
  
  CONCLUSIONS
  Both endogenous hormones failed to demonstrate significant difference in respect to potential direct effect to mechanisms of enhanced intestinal adaptation in reversed group.
authors.affiliation: Department of HBP Surgery, Freeman Hospital, Freeman Road, Newcastle S57AU, UK. mp1977gr@googlemail.com
authors.forename: Michail
authors.initials: M
authors.lastname: Papamichail
authors.forename: Michail
authors.initials: M
authors.lastname: Digalakis
authors.forename: Prigouris
authors.initials: P
authors.lastname: Panagiotis
authors.forename: Odysseas
authors.initials: O
authors.lastname: Paisios
authors.forename: Soyltana
authors.initials: S
authors.lastname: Loti
authors.forename: Theodoros
authors.initials: T
authors.lastname: Sergentanis
mesh_terms: D000222:Adaptation, Physiological; D000818:Animals; D001835:Body Weight; D004195:Disease Models, Animal; D005769:Gastrointestinal Motility; D013006:Growth Hormone / Q000097:blood*; D006801:Humans; D007328:Insulin / Q000097:blood*; D007583:Jejunum / Q000378:metabolism* / Q000601:surgery*; D012709:Serum Albumin / Q000032:analysis; D012778:Short Bowel Syndrome / Q000097:blood* / Q000601:surgery*; D013552:Swine
chemical_list: D007328:Insulin; D012709:Serum Albumin; D013006:Growth Hormone