title: [Evaluation of biological effects and possible mechanisms of action of static magnetic field].
abstract: Modern views on mechanisms of interaction between static magnetic field and cells or cellular structures are reviewed. An analysis of the data about possible biotropic effects of this factor was performed. The emphasis was put on the analysis of the studies in which moderate (0.1-1 T) static magnetic fields were used, because such fields are used for targeted delivery ofmagnetosensitive nanocomposites in development of new strategies in target therapy of patients with malignant neoplasms. Based on available data it was concluded that the primary cause of changes in cells after incubation in external static magnetic field is disruption of free radical metabolism and elevation of their concentration. Such disruption causes oxidative stress, and, as a result, damages ion channels, leading to changes in cell morphology and expression of different genes and proteins, and also changes in apoptosis and proliferation.
authors.forename: V F
authors.initials: VF
authors.lastname: Chekhun
authors.forename: D V
authors.initials: DV
authors.lastname: Demash
authors.forename: L A
authors.initials: LA
authors.lastname: Nalieskina
mesh_terms: D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000627:therapeutic use; D017209:Apoptosis; D049109:Cell Proliferation; D016503:Drug Delivery Systems / Q000379:methods; D005609:Free Radicals / Q000819:agonists* / Q000378:metabolism; D015870:Gene Expression; D006801:Humans; D007473:Ion Channels / Q000378:metabolism; D017136:Ion Transport; D060526:Magnetic Fields / Q000009:adverse effects*; D058185:Magnetite Nanoparticles / Q000627:therapeutic use*; D009369:Neoplasms / Q000188:drug therapy; D018384:Oxidative Stress
chemical_list: D000970:Antineoplastic Agents; D005609:Free Radicals; D007473:Ion Channels; D058185:Magnetite Nanoparticles