title: Acute and long-term hemodynamic effects of sesame oil consumption in hypertensive men.
abstract: The possible effects of sesame oil on hemodynamics are unknown. The aim of the study was to investigate the acute and long-term effects of sesame oil on hemodynamic responses in hypertensive men. The authors enrolled 30 hypertensive men in a two-phase study. In the first phase, patients consumed 35 g of either sesame oil or control oil. Central and peripheral blood pressure, pulse wave velocity, augmentation index (AI), C-reactive protein, tumor necrosis factor α, malonydealdehyde, and total antioxidant capacity (TAC) were assessed at fast and 2 hours postprandially. In the second phase, patients consumed 35 g of either sesame oil or control oil daily for 2 months. The above-mentioned parameters were assessed before and following 15, 30, and 60 days of oil consumption. Sesame oil decreased central and peripheral diastolic pressures 1 hour postprandially (P=.006). Fifteen days of sesame oil intake decreased peripheral systolic blood pressure (P=.016) and heart rate-corrected AI75 (P=.017) and increased TAC (P=.007). This is the first study to demonstrate a favorable acute and long-term effect of sesame oil on hemodynamics in hypertensive men. Further research is warranted to establish the potential protective role of sesame oil.
authors.affiliation: Department of Nutrition and Dietetics, Harokopio University, Athens, Greece.
authors.forename: Kalliopi
authors.initials: K
authors.lastname: Karatzi
authors.forename: Kimon
authors.initials: K
authors.lastname: Stamatelopoulos
authors.forename: Marita
authors.initials: M
authors.lastname: Lykka
authors.forename: Pigi
authors.initials: P
authors.lastname: Mantzouratou
authors.forename: Sofia
authors.initials: S
authors.lastname: Skalidi
authors.forename: Efstathios
authors.initials: E
authors.lastname: Manios
authors.forename: George
authors.initials: G
authors.lastname: Georgiopoulos
authors.forename: Nikolaos
authors.initials: N
authors.lastname: Zakopoulos
authors.forename: Christos
authors.initials: C
authors.lastname: Papamichael
authors.forename: Labros S
authors.initials: LS
authors.lastname: Sidossis
mesh_terms: D001794:Blood Pressure / Q000187:drug effects; D006439:Hemodynamics / Q000187:drug effects*; D006801:Humans; D006973:Hypertension / Q000188:drug therapy* / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D018384:Oxidative Stress; D019518:Postprandial Period; D012715:Sesame Oil / Q000494:pharmacology*
chemical_list: D012715:Sesame Oil