title: [Research advances of hepcidin expression and its regulation mechanism].
abstract: Hepcidin can regulate cell irons' efflux transport. The expression of hepcidin can be influenced by the body signals (such as serum ferritin and erythropoietin levels) as well as inflammation, hypoxia and other disease states. These stimulus activate the signaling pathway of BMP-the SMAD, the JAK-STAT and HIF1 through the liver parenchymal cell surface type I transmembrane glycoprotein of HFE, transferrin receptor 1, 2, hepcidin regulatory proteins, thereby changing the hepcidin gene transcription, regulating the expression levels of hepcidin. However, the molecular mechanism that regulate hepcidin expression is unclear. From the signal factors that affect hepcidin expression and signaling pathways involved in its expression, the latest research progress on regulatory mechanism of hepcidin are summarized.
authors.affiliation: Department of Hematology, Shanghai Jiaotong University, Shanghai, China. changchunkang7010@yahoo.cn
authors.forename: Chun-Kang
authors.initials: CK
authors.lastname: Chang
authors.forename: Xi
authors.initials: X
authors.lastname: Zhang
authors.forename: Chao
authors.initials: C
authors.lastname: Xiao
authors.forename: Shu-Cheng
authors.initials: SC
authors.lastname: Gu
authors.forename: Xiao
authors.initials: X
authors.lastname: Li
mesh_terms: D000818:Animals; D023181:Antimicrobial Cationic Peptides / Q000378:metabolism*; D064451:Hepcidins; D006801:Humans; D008565:Membrane Proteins / Q000378:metabolism*; D015398:Signal Transduction
chemical_list: D023181:Antimicrobial Cationic Peptides; C578702:HAMP protein, human; D064451:Hepcidins; D008565:Membrane Proteins