title: Friction-mediated dynamic disordering of phospholipid membrane by mechanical motions of photoresponsive molecular glue: activation of ion permeation.
abstract: A water-soluble photoresponsive molecular glue, Azo-(18)Glue, consisting of a photochromic azobenzene core and two adhesive dendritic wedges with a total of 18 peripheral guanidinium ion (Gu(+)) pendants tightly adheres to the surface of a phospholipid membrane, even in buffer, via a multivalent salt-bridge formation with phosphate anions. A photomechanical motion of adhering Azo-(18)Glue possibly gives rise to dynamic structural disordering of the phospholipid membrane and activates transmembrane ion permeation. In sharp contrast, no activation of ion permeation results when poorly adhesive Azo-(6)Glue carrying only six Gu(+) pendants is used in place of Azo-(18)Glue.
authors.affiliation: Department of Chemistry and Biotechnology, School of Engineering, The University of Tokyo, 7-3-1 Hongo, Tokyo 113-8656, Japan.
authors.forename: Yushi
authors.initials: Y
authors.lastname: Suzuki
authors.forename: Kou
authors.initials: K
authors.lastname: Okuro
authors.forename: Tadashi
authors.initials: T
authors.lastname: Takeuchi
authors.forename: Takuzo
authors.initials: T
authors.lastname: Aida
mesh_terms: D017276:Friction; D007477:Ions; D010539:Permeability; D010743:Phospholipids / Q000737:chemistry*; D055668:Photochemical Processes
chemical_list: D007477:Ions; D010743:Phospholipids