title: Concurrent ivermectin and Solanum spp. toxicosis in a herd of horses.
abstract: BACKGROUND
  Representatives from a herd of horses with acute onset of neurologic signs after administration of ivermectin presented for evaluation and treatment.
  
  
  OBJECTIVE
  Describe clinical signs of horses intoxicated by ingestion of Solanum sp. and administered ivermectin.
  
  
  METHODS
  Six of 11 affected unrelated horses presented for evaluation and treatment. The remaining 5 affected horses were treated at the farm. Four additional horses, housed separately, were unaffected.
  
  
  METHODS
  Case series is presented. Serum ivermectin concentrations were evaluated in the 6 hospitalized horses. The remnants of the tubes of ivermectin paste were analyzed for ivermectin concentration. The hay fed to the affected horses was analyzed for the presence of toxic plants.
  
  
  RESULTS
  Serum ivermectin concentrations were higher than expected, given the dosage of ivermectin administered. The ivermectin concentration remaining in the administration tubes did not exceed specifications. The hay was heavily contaminated by 2 Solanum species. All horses returned to normal neurologic function with supportive care.
  
  
  CONCLUSIONS
  Horses might exhibit signs of ivermectin toxicity after appropriate dosing of the drug if they concurrently consume toxic plants of the Solanum family.
authors.affiliation: Department of Large Animal Clinical Sciences, Texas A&M University College of Veterinary Medicine and Biomedical Sciences, College Station, TX 77843, USA. tnorman@cvm.tamu.edu
authors.forename: T E
authors.initials: TE
authors.lastname: Norman
authors.forename: M K
authors.initials: MK
authors.lastname: Chaffin
authors.forename: P L
authors.initials: PL
authors.lastname: Norton
authors.forename: M C
authors.initials: MC
authors.lastname: Coleman
authors.forename: W B
authors.initials: WB
authors.lastname: Stoughton
authors.forename: T
authors.initials: T
authors.lastname: Mays
mesh_terms: D000818:Animals; D000977:Antiparasitic Agents / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D002493:Central Nervous System Diseases / Q000139:chemically induced / Q000473:pathology / Q000662:veterinary*; D005506:Food Contamination; D041743:Herb-Drug Interactions; D006734:Horse Diseases / Q000139:chemically induced* / Q000473:pathology; D006736:Horses; D007559:Ivermectin / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D010947:Plants, Toxic; D032322:Solanum / Q000145:classification / Q000633:toxicity*
chemical_list: D000977:Antiparasitic Agents; D007559:Ivermectin