title: Role of immune escape mechanisms in Hodgkin's lymphoma development and progression: a whole new world with therapeutic implications.
abstract: Hodgkin's lymphoma represents one of the most frequent lymphoproliferative syndromes, especially in young population. Although HL is considered one of the most curable tumors, a sizeable fraction of patients recur after successful upfront treatment or, less commonly, are primarily resistant. This work tries to summarize the data on clinical, histological, pathological, and biological factors in HL, with special emphasis on the improvement of prognosis and their impact on therapeutical strategies. The recent advances in our understanding of HL biology and immunology show that infiltrated immune cells and cytokines in the tumoral microenvironment may play different functions that seem tightly related with clinical outcomes. Strategies aimed at interfering with the crosstalk between tumoral Reed-Sternberg cells and their cellular partners have been taken into account in the development of new immunotherapies that target different cell components of HL microenvironment. This new knowledge will probably translate into a change in the antineoplastic treatments in HL in the next future and hopefully will increase the curability rates of this disease.
authors.affiliation: Clinical Oncology Department, Hospital Universitario Virgen Macarena, 41009 Sevilla, Spain. lucme12@yahoo.es
authors.forename: Luis
authors.initials: L
authors.lastname: de la Cruz-Merino
authors.forename: Marylène
authors.initials: M
authors.lastname: Lejeune
authors.forename: Esteban
authors.initials: E
authors.lastname: Nogales Fernández
authors.forename: Fernando
authors.initials: F
authors.lastname: Henao Carrasco
authors.forename: Ana
authors.initials: A
authors.lastname: Grueso López
authors.forename: Ana
authors.initials: A
authors.lastname: Illescas Vacas
authors.forename: Mariano Provencio
authors.initials: MP
authors.lastname: Pulla
authors.forename: Cristina
authors.initials: C
authors.lastname: Callau
authors.forename: Tomás
authors.initials: T
authors.lastname: Álvaro
mesh_terms: D016207:Cytokines / Q000097:blood; D003713:Dendritic Cells / Q000276:immunology; D018450:Disease Progression; D006689:Hodgkin Disease / Q000276:immunology* / Q000473:pathology / Q000628:therapy; D006801:Humans; D016867:Immunocompromised Host; D007167:Immunotherapy; D007694:Killer Cells, Natural / Q000276:immunology; D008214:Lymphocytes / Q000276:immunology; D008264:Macrophages / Q000276:immunology; D009504:Neutrophils / Q000276:immunology; D016539:Reed-Sternberg Cells / Q000276:immunology / Q000378:metabolism; D019139:Tumor Escape; D059016:Tumor Microenvironment
chemical_list: D016207:Cytokines