title: Primary Amoebic Meningoencephalitis in an Infant due to Naegleria fowleri.
abstract: Primary amoebic meningoencephalitis (PAM) caused by free-living amebae Naegleria fowleri is a rare and fatal condition. A fatal case of primary amoebic meningoencephalitis was diagnosed in a 5-month-old infant who presented with the history of decrease breast feeding, fever, vomiting, and abnormal body movements. Trophozoites of Naegleria fowleri were detected in the direct microscopic examination of CSF and infant was put on amphotericin B and ceftazidime. Patient condition deteriorated, and he was discharged against medical advice and subsequently expired. We also reviewed previously reported 8 Indian cases of primary amoebic meningoencephalitis (PAM) and observed that for the last 5 years, none of the patients responded to amphotericin B. Has an era of amphotericin B-resistant Naegleria fowleri been emerged? Management strategy of PAM needs to be reviewed further.
authors.affiliation: Department of Microbiology, Kasturba Medical College, Manipal, 576104 Karnataka, India.
authors.forename: Vinay
authors.initials: V
authors.lastname: Khanna
authors.forename: Ruchee
authors.initials: R
authors.lastname: Khanna
authors.forename: Shrikiran
authors.initials: S
authors.lastname: Hebbar
authors.forename: V
authors.initials: V
authors.lastname: Shashidhar
authors.forename: Sunil
authors.initials: S
authors.lastname: Mundkar
authors.forename: Frenil
authors.initials: F
authors.lastname: Munim
authors.forename: Karthick
authors.initials: K
authors.lastname: Annamalai
authors.forename: Deepak
authors.initials: D
authors.lastname: Nayak
authors.forename: Chiranjay
authors.initials: C
authors.lastname: Mukhopadhayay