title: [Comprehensive analysis on variation of cardiac enzyme and troponin induced by acute organophosphorous poisoning].
abstract: OBJECTIVE
  To discuss the diagnostic value of cardiac enzyme and troponin in acute organophosphorus pesticide poisoning (AOPP).
  
  
  METHODS
  A retrospective study was performed in the document published in domestic journals and PubMed from 1979 to 2010. The data of the cardiac enzyme and troponin were collected. Statistical analysis was conducted with one-way ANOVA and rank sum test. 2129 cases with AOPP were enrolled.
  
  
  RESULTS
  The levels of creatine kinase (CK), creatine kinase-MB (CK-MB) and cardiac troponin I (cTnI) in milder, moderate and severe poisoning groups were significantly elevated compared by the healthy control group (P < 0.05). The differences were also dramatic among three patients groups (P < 0.05). The ratios of CK-MB to CK in both moderate and severe groups were significantly lower than in healthy controls (P < 0.05). The levels of CK, CK-MB and cTnI were higher especially in patients with intermediate myasthenic syndrome (IMS) than patients without IMS. Meanwhile, the levels of CK and CK-MB were elevated in patients with respiratory failure compared by non-failure ones, but decreased in the ratios of CK-MB to CK (P < 0.05).
  
  
  CONCLUSIONS
  The elevation of CK and CK-MB in serum could not be judged as the criteria of myocardial damage in AOPP, the ratio of CK-MB to CK were more valuable; the value of cTnI in myocardial damage was still in suspect. CK, CK-MB and cTnI could be used as auxiliary criteria of AOPP classification.
authors.affiliation: Department of Occupational diseases, Huashan Hosipital, Fudan University, Shanghai 200040, China.
authors.forename: Wei-guo
authors.initials: WG
authors.lastname: Wan
authors.forename: Li
authors.initials: L
authors.lastname: Jiang
authors.forename: Shu-cong
authors.initials: SC
authors.lastname: Zheng
authors.forename: Hao-min
authors.initials: HM
authors.lastname: Qiu
authors.forename: Dan-dan
authors.initials: DD
authors.lastname: Xuan
authors.forename: He-jian
authors.initials: HJ
authors.lastname: Zou
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D009202:Cardiomyopathies / Q000175:diagnosis* / Q000209:etiology; D002648:Child; D002675:Child, Preschool; D003402:Creatine Kinase / Q000097:blood; D052279:Creatine Kinase, MB Form / Q000097:blood; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D008875:Middle Aged; D009206:Myocardium / Q000201:enzymology / Q000378:metabolism* / Q000473:pathology; D062025:Organophosphate Poisoning / Q000378:metabolism*; D019210:Troponin I / Q000097:blood; D020107:Troponin T / Q000097:blood; D055815:Young Adult
chemical_list: D019210:Troponin I; D020107:Troponin T; D003402:Creatine Kinase; D052279:Creatine Kinase, MB Form