title: Aging and neoteny in the B lineage.
abstract: Aging and the physiologic decline of tissues and cells were once thought to be irreversible. However, recent studies suggest that various tissues, especially parts of the hematopoietic system, can be rejuvenated. Here we review potential mechanisms for this process and how they may be used to reverse age-related disorders and aging in general. We propose the novel hypothesis that altering the homeostatic process during cellular depletion can reverse aging in the hematopoietic system.
authors.affiliation: Department of Immunology, Faculty of Medicine, Technion-Israel Institute of Technology, Haifa 31096, Israel. melamedd@tx.technion.ac.il.
authors.forename: Doron
authors.initials: D
authors.lastname: Melamed
authors.forename: David W
authors.initials: DW
authors.lastname: Scott
mesh_terms: D000375:Aging / Q000235:genetics / Q000276:immunology / Q000473:pathology / Q000502:physiology*; D000818:Animals; D058846:Antibodies, Monoclonal, Murine-Derived / Q000494:pharmacology / Q000627:therapeutic use; D001402:B-Lymphocytes / Q000166:cytology*; D002455:Cell Division; D019070:Cell Lineage; D019942:Genes, p16; D015316:Genetic Therapy; D006412:Hematopoietic Stem Cells / Q000166:cytology; D006413:Hematopoietic System / Q000166:cytology / Q000502:physiology; D006706:Homeostasis / Q000502:physiology*; D006801:Humans; D016131:Lymphocyte Subsets / Q000166:cytology; D008214:Lymphocytes / Q000166:cytology; D038041:Lymphopoiesis / Q000187:drug effects / Q000502:physiology; D051379:Mice; D008822:Mice, Transgenic; D008954:Models, Biological; D010227:Parabiosis; D039904:Pluripotent Stem Cells / Q000166:cytology; D017346:Protein Serine-Threonine Kinases / Q000235:genetics / Q000502:physiology; D012038:Regeneration / Q000502:physiology; D000069283:Rituximab; D013950:Thymus Gland / Q000166:cytology / Q000254:growth & development
chemical_list: D058846:Antibodies, Monoclonal, Murine-Derived; D000069283:Rituximab; C090464:Bub1 spindle checkpoint protein; D017346:Protein Serine-Threonine Kinases