title: Adrenomedullin is involved in the progression of colonic adenocarcinoma.
abstract: Adrenomedullin (ADM), initially identified in human pheochromocytoma, participates             in a wide range of physiological and pathological processes, including vasorelaxation,             angiogenesis and apoptosis. Recent studies have reported that ADM protected tumor             cells against apoptotic cell death via the upregulation of Bcl-2 or the activation             of the phosphatidylinositol 3-kinase/Akt pathway. Several studies have also provided             evidence that ADM is involved in tumor initiation and progression. However, this             has not been shown in gastrointestinal tumors. To investigate the role of ADM             in gastrointestinal tumor progression, we determined the expression levels of             ADM in 72 cases of stomach cancer and 84 cases of colon cancer and determined             whether there was an association between the ADM expression levels and pathological             parameters or clinical survival rates. We found that the expression levels of             ADM were significantly higher in colon cancers than in matching normal mucosal             tissues. In addition, the expression levels of ADM in colon cancers were correlated             with cancer stage and clinical survival rate. However, we did not find any significant             correlations between ADM expression levels and clinical or pathological parameters             in stomach cancers. Taken together, our data strongly suggest that ADM is involved             in the progression of colon cancer.
authors.affiliation: Department of Pathology, School of Medicine, Kyung Hee University,                     Seoul 130-701, Republic of Korea.
authors.forename: Jee-Youn
authors.initials: JY
authors.lastname: Kim
authors.forename: Won-Do
authors.initials: WD
authors.lastname: Park
authors.forename: Sun
authors.initials: S
authors.lastname: Lee
authors.forename: Jae-Hoon
authors.initials: JH
authors.lastname: Park
mesh_terms: D000230:Adenocarcinoma / Q000378:metabolism / Q000401:mortality / Q000473:pathology*; D053607:Adrenomedullin / Q000235:genetics / Q000378:metabolism*; D003110:Colonic Neoplasms / Q000378:metabolism / Q000401:mortality / Q000473:pathology*; D006801:Humans; D007150:Immunohistochemistry; D053208:Kaplan-Meier Estimate; D009367:Neoplasm Staging; D013274:Stomach Neoplasms / Q000378:metabolism / Q000473:pathology
chemical_list: D053607:Adrenomedullin