title: Overweight - early stage of "adipokines related cardiovascular    diseases": leptin and adiponectin relation to anthropometric    parametars.
abstract: OBJECTIVE
  Adipose tissue possess endocrine functions that include synthesis of various adipocytokines, which affect the metabolism of lipids and glucoses, development of atherosclerotic processes, and are involved in the development of hypertension and cardiovascular diseases. Body fat distribution is a significant risk factor for the development of obesity related diseases. Leptin and adiponectin are adipokines whose concentrations vary with the level of obesity. The aim of this research is to determine the relation of the changes in leptin and adiponectin concentrations in overweight persons with anthropometric parameters of the subjects.
  
  
  METHODS
  The study included 40 adult, hypertensive subjects - divided into two groups according to sex, with the body mass index 25-30 kg/m², with regular glycemia and renal function. All subjects underwent biochemical (serum lipid, glucose and creatinine level) and anthropometric measurements. Leptin concentration was determined by radioimmunoassay, while adiponectin concentration was determined by enzyme immunoassay.
  
  
  RESULTS
  Both leptin and adiponectin concentrations significantly correlated with the waist circumference in both groups of subjects. In male subjects, leptin concentration correlated positively with the body mass index and the hip circumference, while adiponectin concentration correlated negatively with the hip circumference.
  
  
  CONCLUSIONS
  Being overweight is a condition marked by pathologically altered values of leptin concentration (increased level) and adiponectin (decreased level), that are changing as the obesity level and the waist circumference increase. It can be concluded that abdominal obesity and higher body mass index increase the risk for the development of overweight-obesity-related diseases.
authors.affiliation: Clinic for Internal Medicine, Clinical Hospital Centre Osijek, Croatia. selthofer.relatic@gmail.com
authors.forename: Kristina
authors.initials: K
authors.lastname: Selthofer-Relatić
authors.forename: Dalibor
authors.initials: D
authors.lastname: Divković
authors.forename: Radivoje
authors.initials: R
authors.lastname: Radić
authors.forename: Vedrana
authors.initials: V
authors.lastname: Vizjak
authors.forename: Robert
authors.initials: R
authors.lastname: Selthofer
authors.forename: Robert
authors.initials: R
authors.lastname: Steiner
authors.forename: Ivica
authors.initials: I
authors.lastname: Bošnjak
mesh_terms: D052242:Adiponectin / Q000097:blood*; D000328:Adult; D015992:Body Mass Index; D049628:Body Size; D002318:Cardiovascular Diseases / Q000097:blood; D005260:Female; D006801:Humans; D006973:Hypertension / Q000150:complications; D020738:Leptin / Q000097:blood*; D008297:Male; D050177:Overweight / Q000097:blood* / Q000150:complications; D055105:Waist Circumference
chemical_list: D052242:Adiponectin; D020738:Leptin