title: Correlation of von Willebrand factor gene polymorphism and coronary             heart disease.
abstract: To characterize von Willebrand factor (vWF) gene polymorphisms at site A1381T             and the correlation of plasma vWF levels with coronary heart disease, the vWF             genotypes at site A1381T were analyzed by polymerase chain reaction-restriction             fragment length polymorphism (PCR-RFLP) in patients diagnosed with coronary heart             disease and normal controls (n=110 per group), and plasma vWF levels were measured             by enzyme‑linked immunosorbent assay. The results showed that the plasma vWF levels             were higher in the experimental group than in the control group and had no association             with gender (t=11.69, p<0.05). In the experimental group, the plasma vWF levels             were higher in the patients with the AG genotype than in those with the GG genotype             (p<0.05). In the control group, the plasma vWF levels of the subjects with             blood type O were significantly lower than those of the individuals with other             blood types (p<0.05). In the experimental group, all blood types had significantly             higher plasma vWF levels than the control group and the difference was significant             among different blood types (p<0.05). In summary, vWF gene polymorphisms at             site A1381T were not associated with coronary heart disease, but plasma vWF levels             were influenced by vWF gene polymorphisms at site A1381T, blood type and coronary             heart disease.
authors.affiliation: Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052, PR China. zhengxuag@126.com
authors.forename: Ai-Guo
authors.initials: AG
authors.lastname: Xu
authors.forename: Rong-Mei
authors.initials: RM
authors.lastname: Xu
authors.forename: Chang-Qing
authors.initials: CQ
authors.lastname: Lu
authors.forename: Meng-Ying
authors.initials: MY
authors.lastname: Yao
authors.forename: Wei
authors.initials: W
authors.lastname: Zhao
authors.forename: Xin
authors.initials: X
authors.lastname: Fu
authors.forename: Jing
authors.initials: J
authors.lastname: Guo
authors.forename: Qin-Fu
authors.initials: QF
authors.lastname: Xu
authors.forename: Dan-Dan
authors.initials: DD
authors.lastname: Li
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000483:Alleles; D003327:Coronary Disease / Q000235:genetics*; D005260:Female; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D014841:von Willebrand Factor / Q000032:analysis / Q000235:genetics*
chemical_list: D014841:von Willebrand Factor