title: Synthesis of enantiomerically enriched 3-amino-2-oxindoles through a palladium-mediated asymmetric intramolecular arylation of α-ketimino amides.
abstract: A highly efficient and enantioselective synthesis of 3-amino-2-oxindoles through a palladium-catalyzed asymmetric intramolecular arylation of α-ketimino amides using (R)-DiFluorPhos as the coordinating ligand is reported. This report constitutes the first enantioselective palladium-catalyzed arylation of ketimines.
authors.affiliation: Department of Chemistry, University of Cambridge, Lensfield Road, CB2 1EW, United Kingdom.
authors.forename: Päivi
authors.initials: P
authors.lastname: Tolstoy
authors.forename: Samantha X Y
authors.initials: SX
authors.lastname: Lee
authors.forename: Christof
authors.initials: C
authors.lastname: Sparr
authors.forename: Steven V
authors.initials: SV
authors.lastname: Ley
mesh_terms: D000577:Amides / Q000737:chemistry*; D002384:Catalysis; D020650:Combinatorial Chemistry Techniques; D007097:Imines / Q000737:chemistry*; D007211:Indoles / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D009570:Nitriles / Q000737:chemistry*; D000078183:Oxindoles; D010165:Palladium / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: C551521:3-amino-2-oxindole; D000577:Amides; D007097:Imines; D007211:Indoles; D009570:Nitriles; D000078183:Oxindoles; C542835:ketimine; D010165:Palladium