title: Structural considerations for chromatin state models with transcription as a functional readout.
abstract: Lacking from the rapidly evolving field of chromatin regulation is a discrete model of chromatin states. We propose that each state in such a model should meet two conditions: a structural component and a quantifiable effect on transcription. The practical benefits to the field of a model with greater than two states (including one with six states, as described herein) would be to improve interpretation of data from disparate organ systems, to reflect temporal and developmental dynamics and to integrate the, at present, conceptually and experimentally disparate analyses of individual genetic loci (in vitro or using single gene approaches) and genome-wide features (including ChlP-seq, chromosomal capture and mRNA expression via microarrays/sequencing).
authors.affiliation: Department of Anesthesiology, David Geffen School of Medicine at UCLA, United States.
authors.forename: Haodong
authors.initials: H
authors.lastname: Chen
authors.forename: Emma
authors.initials: E
authors.lastname: Monte
authors.forename: Michelle S
authors.initials: MS
authors.lastname: Parvatiyar
authors.forename: Manuel
authors.initials: M
authors.lastname: Rosa-Garrido
authors.forename: Sarah
authors.initials: S
authors.lastname: Franklin
authors.forename: Thomas M
authors.initials: TM
authors.lastname: Vondriska
mesh_terms: D000818:Animals; D002843:Chromatin / Q000737:chemistry* / Q000235:genetics*; D006801:Humans; D008954:Models, Biological; D014158:Transcription, Genetic
chemical_list: D002843:Chromatin