title: Assessment of macular function of glaucomatous eyes by multifocal electroretinograms.
abstract: OBJECTIVE
  To determine whether significant correlations existed between the morphological and functional parameters of the macular region of eyes with open-angle glaucoma (OAG).
  
  
  METHODS
  Forty eyes of 40 OAG patients were studied. The morphological parameters were obtained by optical coherence tomography (OCT), and the functional parameters were acquired by automated Humphrey Field Analyzer (HFA) and multifocal electroretinograms (mfERGs). All of the tests were performed within 6 months of each other. The retinal thickness was determined by OCT in the nine Early Treatment of Diabetic Retinopathy Study (ETDRS) sectors of the macula, the fovea, and the four quadrants of the inner and an outer ring. The amplitudes of the second-order kernel responses of the mfERGs in the central 5° including the amplitude ratio of the nasal to temporal hemispheres (N/T amplitude ratio) were analyzed. The total mean deviation of the HFA corresponding to each OCT region was measured. The correlation between the different parameters was determined by coefficients of correlation and linear regression analyses.
  
  
  RESULTS
  The N/T amplitude ratio of the second-order kernel responses of the mfERGs was significantly correlated with the retinal thickness in the inferior quadrant (r = -0.44; P = 0.004). There was a significant correlation between the N/T amplitude ratio and the threshold in the superior quadrant measured by the HFA Central 10-2 program (r = -0.40; P = 0.011) and also between the N/T amplitude ratio and the total deviation in the superior quadrant (r = -0.40; P = 0.010). There were significant correlations between the inferior retinal thickness and the average threshold and the TD in superior (r = 0.70, P < 0.001; r = 0.692, P < 0.001, respectively), nasal (r = 0.53, P < 0.001; r = 0.53, P < 0.001, respectively), and temporal (r = 0.46, P = 0.003; r = 0.44, P = 0.004, respectively) quadrants.
  
  
  CONCLUSIONS
  Functional glaucomatous changes determined by mfERGs and perimetry are significantly correlated with the morphological changes determined by OCT.
authors.affiliation: Department of Ophthalmology, Gifu University Graduate School of Medicine, 1-1 Yanagido, Gifu-shi, 501-1194, Japan.
authors.forename: Nobuhide
authors.initials: N
authors.lastname: Hori
authors.affiliation: Department of Ophthalmology, Gifu University Graduate School of Medicine, 1-1 Yanagido, Gifu-shi, 501-1194, Japan.
authors.forename: Shinya
authors.initials: S
authors.lastname: Komori
authors.affiliation: Department of Ophthalmology, Gifu University Graduate School of Medicine, 1-1 Yanagido, Gifu-shi, 501-1194, Japan.
authors.forename: Hiroki
authors.initials: H
authors.lastname: Yamada
authors.affiliation: Department of Ophthalmology, Gifu University Graduate School of Medicine, 1-1 Yanagido, Gifu-shi, 501-1194, Japan. sawadaa-gif@umin.ac.jp.
authors.forename: Akira
authors.initials: A
authors.lastname: Sawada
authors.affiliation: Department of Ophthalmology, Gifu University Graduate School of Medicine, 1-1 Yanagido, Gifu-shi, 501-1194, Japan.
authors.forename: Yasunori
authors.initials: Y
authors.lastname: Nomura
authors.affiliation: Department of Ophthalmology, Gifu University Graduate School of Medicine, 1-1 Yanagido, Gifu-shi, 501-1194, Japan.
authors.forename: Kiyofumi
authors.initials: K
authors.lastname: Mochizuki
authors.affiliation: Department of Ophthalmology, Gifu University Graduate School of Medicine, 1-1 Yanagido, Gifu-shi, 501-1194, Japan.
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Yamamoto
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003430:Cross-Sectional Studies; D004596:Electroretinography; D005260:Female; D005902:Glaucoma, Open-Angle / Q000503:physiopathology*; D006801:Humans; D007429:Intraocular Pressure / Q000502:physiology; D008297:Male; D008875:Middle Aged; D009412:Nerve Fibers; D012160:Retina / Q000503:physiopathology*; D012165:Retinal Ganglion Cells; D041623:Tomography, Optical Coherence; D058609:Visual Field Tests; D014794:Visual Fields / Q000502:physiology