title: Pancreatic neuroendocrine paraneoplastic optic neuropathy:  confirmation with antibody to optic nerve and hepatic metastasis.
abstract: A 68-year-old woman presented with bilateral visual loss as the only clinical manifestation of an occult pancreatic nonsecretory neuroendocrine tumor (NET). The suspected diagnosis of paraneoplastic optic neuropathy was confirmed using immunofluorescence assays to demonstrate the presence of antibodies in the patient's serum that reacted with antigen(s) in the optic nerve and in the pancreatic NET hepatic metastasis. Treatment of the underlying cancer was followed by marked improvement in visual function.
authors.affiliation: Department of Ophthalmology, Neurology and Neurosurgery, Albert Einstein College of Medicine, Bronx, NY, USA. tlslam@gmail.com
authors.forename: Thomas L
authors.initials: TL
authors.lastname: Slamovits
authors.forename: Jerome B
authors.initials: JB
authors.lastname: Posner
authors.forename: Diane L
authors.initials: DL
authors.lastname: Reidy
authors.forename: Charles E
authors.initials: CE
authors.lastname: Thirkill
authors.forename: John L
authors.initials: JL
authors.lastname: Keltner
mesh_terms: D000368:Aged; D005260:Female; D006801:Humans; D018358:Neuroendocrine Tumors / Q000473:pathology / Q000503:physiopathology*; D009900:Optic Nerve / Q000276:immunology / Q000503:physiopathology*; D009901:Optic Nerve Diseases / Q000175:diagnosis* / Q000276:immunology / Q000503:physiopathology; D010190:Pancreatic Neoplasms / Q000473:pathology / Q000503:physiopathology*; D059545:Paraneoplastic Syndromes, Ocular / Q000175:diagnosis* / Q000276:immunology / Q000503:physiopathology; D014786:Vision Disorders / Q000175:diagnosis* / Q000276:immunology / Q000503:physiopathology; D014792:Visual Acuity / Q000502:physiology