title: Toxicity by NSAIDs. Counteraction by stable gastric pentadecapeptide BPC 157.
abstract: Stable gastric pentadecapeptide BPC 157 is an anti-ulcer peptidergic agent, proven in clinical trials to be both safe in inflammatory bowel disease (PL-10, PLD-116, PL 14736) and wound healing, stable in human gastric juice, with no toxicity being reported. Recently, we claim that BPC 157 may be used as an antidote against NSAIDs. We focused on BPC 157 beneficial effects on stomach, duodenum, intestine, liver and brain injuries, adjuvant arthritis, pain, hyper/hypothermia, obstructive thrombus formation and thrombolysis, blood vessel function, counteraction of prolonged bleeding and thrombocytopenia after application of various anticoagulants and antiplatelet agents and wound healing improvement. The arguments for BPC 157 antidote activity (i.e., the role of BPC 157 in cytoprotection, being a novel mediator of Robert's cytoprotection and BPC 157 beneficial effects on NSAIDs mediated lesions in the gastrointestinal tract, liver and brain and finally, counteraction of aspirin-induced prolonged bleeding and thrombocytopenia) obviously have a counteracting effect on several established side-effects of NSAIDs use. The mentioned variety of the beneficial effects portrayed by BPC 157 may well be a foundation for establishing BPC 157 as a NSAIDs antidote since no other single agent has portrayed a similar array of effects. Unlike NSAIDs, a very high safety (no reported toxicity (LD1 could be not achieved)) profile is reported for BPC 157. Also, unlike the different dosage levels of aspirin, as a NSAIDs prototype, which differ by a factor of about ten, all these beneficial and counteracting effects of BPC 157 were obtained using the equipotent dosage (μg, ng/kg) in parenteral or peroral regimens.
authors.affiliation: Department of Pharmacology and Pathology, Medical Faculty University of Zagreb, Salata 11, POB 916, 10000 Zagreb, Croatia. sikiric@mef.hr; psikiric@gmail.com
authors.forename: Predrag
authors.initials: P
authors.lastname: Sikiric
authors.forename: Sven
authors.initials: S
authors.lastname: Seiwerth
authors.forename: Rudolf
authors.initials: R
authors.lastname: Rucman
authors.forename: Branko
authors.initials: B
authors.lastname: Turkovic
authors.forename: Dinko Stancic
authors.initials: DS
authors.lastname: Rokotov
authors.forename: Luka
authors.initials: L
authors.lastname: Brcic
authors.forename: Marko
authors.initials: M
authors.lastname: Sever
authors.forename: Robert
authors.initials: R
authors.lastname: Klicek
authors.forename: Bozo
authors.initials: B
authors.lastname: Radic
authors.forename: Domagoj
authors.initials: D
authors.lastname: Drmic
authors.forename: Spomenko
authors.initials: S
authors.lastname: Ilic
authors.forename: Danijela
authors.initials: D
authors.lastname: Kolenc
authors.forename: Gorana
authors.initials: G
authors.lastname: Aralica
authors.forename: Hana
authors.initials: H
authors.lastname: Safic
authors.forename: Jelena
authors.initials: J
authors.lastname: Suran
authors.forename: Davor
authors.initials: D
authors.lastname: Rak
authors.forename: Senka
authors.initials: S
authors.lastname: Dzidic
authors.forename: Hrvoje
authors.initials: H
authors.lastname: Vrcic
authors.forename: Bozidar
authors.initials: B
authors.lastname: Sebecic
mesh_terms: D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects*; D000897:Anti-Ulcer Agents / Q000009:adverse effects / Q000494:pharmacology / Q000627:therapeutic use; D000931:Antidotes / Q000009:adverse effects / Q000494:pharmacology / Q000627:therapeutic use*; D001241:Aspirin / Q000009:adverse effects; D001921:Brain / Q000187:drug effects / Q000503:physiopathology; D041981:Gastrointestinal Tract / Q000187:drug effects / Q000503:physiopathology; D006801:Humans; D008099:Liver / Q000187:drug effects / Q000503:physiopathology; D010446:Peptide Fragments / Q000009:adverse effects / Q000494:pharmacology / Q000627:therapeutic use*; D011506:Proteins / Q000009:adverse effects / Q000494:pharmacology / Q000627:therapeutic use*
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D000897:Anti-Ulcer Agents; D000931:Antidotes; D010446:Peptide Fragments; D011506:Proteins; C083833:BPC 157; D001241:Aspirin