title: Parallel chemistry in the 21st century.
abstract: The tool chest of techniques, methodologies, and equipment for conducting parallel chemistry is larger than ever before. Improvements in the laboratory and developments in computational chemistry have enabled compound library design at the desks of medicinal chemists. This unit includes a brief background in combinatorial/parallel synthesis chemistry, along with a discussion of evolving technologies for both solid- and solution-phase chemistry. In addition, there are discussions on designing compound libraries, acquisition/procurement of compounds and/or reagents, the chemistry and equipment used for chemical production, purification, sample handling, and data analysis.
authors.affiliation: SCYNEXIS, Research Triangle Park, NC, USA.
authors.forename: Alan
authors.initials: A
authors.lastname: Long
mesh_terms: D002623:Chemistry Techniques, Analytical / Q000379:methods / Q000639:trends; D002845:Chromatography / Q000379:methods; D020650:Combinatorial Chemistry Techniques / Q000379:methods / Q000639:trends; D015195:Drug Design; D055808:Drug Discovery / Q000295:instrumentation / Q000639:trends*; D006801:Humans; D004364:Pharmaceutical Preparations / Q000138:chemical synthesis* / Q000302:isolation & purification; D054852:Small Molecule Libraries
chemical_list: D004364:Pharmaceutical Preparations; D054852:Small Molecule Libraries