title: Systematized epidermal nevus with epidermolytic hyperkeratosis improving with topical calcipotriol/betametasone dipropionate combination ointment.
abstract: We present the case of a 5-year-old boy who presented with systematized epidermal nevus with evidence of epidermolytic hyperkeratosis on skin biopsy. He was otherwise well, with normal growth and development and no evidence of other organ system involvement. He had experienced only mild improvement with potent topical corticosteroids. He reported more-marked improvement after 2 months of topical calcipotriol/betamethasone dipropionate combination ointment once a day to the lesions. Extensive epidermal nevi can lead to severe cosmetic disfigurement. We recommend a trial of topical calcipotriol/betamethasone dipropionate ointment for patients with extensive epidermal nevus not amenable to surgical treatment.
authors.affiliation: Department of Dermatology, Changi General Hospital, Singapore National Skin Centre, Singapore. docmark@pacific.net.sg
authors.forename: Mark Jean-Aan
authors.initials: MJ
authors.lastname: Koh
authors.forename: Joyce Siong-See
authors.initials: JS
authors.lastname: Lee
authors.forename: Wei-Sheng
authors.initials: WS
authors.lastname: Chong
mesh_terms: D000287:Administration, Topical; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage; D001623:Betamethasone / Q000008:administration & dosage / Q000031:analogs & derivatives*; D002117:Calcitriol / Q000008:administration & dosage / Q000031:analogs & derivatives*; D002675:Child, Preschool; D003879:Dermatologic Agents / Q000008:administration & dosage; D006801:Humans; D017488:Hyperkeratosis, Epidermolytic / Q000150:complications / Q000188:drug therapy* / Q000473:pathology; D008297:Male; D009506:Nevus / Q000150:complications / Q000188:drug therapy / Q000473:pathology; D009824:Ointments / Q000008:administration & dosage; D012878:Skin Neoplasms / Q000150:complications / Q000188:drug therapy* / Q000473:pathology; D016896:Treatment Outcome
chemical_list: D000893:Anti-Inflammatory Agents; D003879:Dermatologic Agents; D009824:Ointments; C055085:calcipotriene; C011175:betamethasone-17,21-dipropionate; D001623:Betamethasone; D002117:Calcitriol