title: Daptomycin efficacy in the central nervous system of a patient with disseminated methicillin-resistant Staphylococcus aureus infection: a case report.
abstract: BACKGROUND
  Staphylococcus aureus has emerged as a major nosocomial pathogen in the last decades and also represents the second most common pathogen isolated from patients in outpatient settings. Although methicillin-resistant S.aureus infections were traditionally limited to hospitals, community-associated cases of methicillin-resistant S.aureus infections have been reported. In our case, we observed an unexpected event during treatment.
  
  
  METHODS
  A 60-year-old Caucasian man developed fever and multiple muscle and brain abscesses caused by Panton-Valentine leukocidin-negative community-associated methicillin-resistant S. aureus.
  
  
  CONCLUSIONS
  Although our patient was given antimicrobials active against the isolated methicillin-resistant S. aureus strain, it was only after the introduction of daptomycin that his skin, soft tissue and muscle lesions and also brain manifestations improved.
authors.affiliation: Second Infectious Diseases Division, National Institute for Infectious Diseases "LazzaroSpallanzani", Via Portuense, 292-00149, Rome, Italy. taglietti.f@gmail.com.
authors.forename: Fabrizio
authors.initials: F
authors.lastname: Taglietti
authors.forename: Floriana
authors.initials: F
authors.lastname: Campanile
authors.forename: Alessandro
authors.initials: A
authors.lastname: Capone
authors.forename: Antonino
authors.initials: A
authors.lastname: Di Caro
authors.forename: Elisabetta
authors.initials: E
authors.lastname: Grilli
authors.forename: Giulia
authors.initials: G
authors.lastname: Stazi
authors.forename: Taschia
authors.initials: T
authors.lastname: Bertuccio
authors.forename: Nicola
authors.initials: N
authors.lastname: Petrosillo
authors.forename: Stefania
authors.initials: S
authors.lastname: Stefani