title: Nanoassemblies from homostructured polypeptides as efficient nanoplatforms for oral drug delivery.
abstract: The assembly of homostructured polypeptides bearing various side groups into well-defined nanostructures was presented, with their size and topology mainly dominated by the chemical structure and molecular weight of peptides. Pharmacokinetic and pharmacodynamic studies based on rat models suggested these newly constructed nanoassemblies with low cytotoxicity may function as novel nanoplatforms to efficiently and safely deliver therapeutics to achieve better efficacy but lower side effects. Other applications in biomedical fields, such as biotechnology, medical imaging, and tissue engineering, may also be expected.
  
  
  BACKGROUND
  This research team investigated the assembly of homostructured polypeptides bearing various side groups into well-defined nanostructures, and demonstrated low cytotoxicity in rat disease models, suggesting that these novel nanoplatforms may safely and efficiently deliver therapeutics with low side effects.
authors.affiliation: Department of Pharmaceutics, College of Pharmacy, Third Military Medical University, Chongqing 400038, China.
authors.forename: Yi
authors.initials: Y
authors.lastname: Jia
authors.forename: Yuan
authors.initials: Y
authors.lastname: Tang
authors.forename: Hongmei
authors.initials: H
authors.lastname: He
authors.forename: Shuhui
authors.initials: S
authors.lastname: Li
authors.forename: Ling
authors.initials: L
authors.lastname: Che
authors.forename: Xing
authors.initials: X
authors.lastname: Zhou
authors.forename: Yin
authors.initials: Y
authors.lastname: Dou
authors.forename: Jianxiang
authors.initials: J
authors.lastname: Zhang
authors.forename: Xiaohui
authors.initials: X
authors.lastname: Li
mesh_terms: D000284:Administration, Oral; D000818:Animals; D016923:Cell Death / Q000187:drug effects; D016503:Drug Delivery Systems; D006367:HeLa Cells; D006801:Humans; D007213:Indomethacin / Q000008:administration & dosage / Q000493:pharmacokinetics / Q000494:pharmacology; D007700:Kinetics; D008297:Male; D051379:Mice; D049329:Nanostructures / Q000737:chemistry* / Q000633:toxicity / Q000648:ultrastructure; D036103:Nanotechnology; D010455:Peptides / Q000138:chemical synthesis / Q000737:chemistry*; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D010455:Peptides; D007213:Indomethacin