title: 12- and 15-lipoxygenases in adipose tissue inflammation.
abstract: The lipoxygenases (LOs) are principal enzymes involved in the oxidative metabolism of polyunsaturated fatty acids, including arachidonic acid. 12- and 15-LO and their lipid metabolites have been implicated in the development of insulin resistance and diabetes. Adipose tissue, and in particular visceral adipose tissue, plays a primary role in the development of the inflammation seen in these conditions. 12- and 15-LO and their lipid metabolites act as upstream regulators of many of the cytokines involved in the inflammatory response in adipose tissue. While the role that 12- and 15-LO play in chronically inflamed adipose tissue is becoming clearer, there are still many questions that remain unanswered regarding their activation, signaling pathways, and roles in healthy fat. 12- and 15-LO also generate products with anti-inflammatory properties that are under investigation. Therefore, 12- and 15-LO have the potential to be very important targets for therapeutics aimed at reducing insulin resistance and the comorbid conditions associated with obesity.
authors.affiliation: Department of Internal Medicine, Strelitz Diabetes Center, Eastern Virginia Medical School, Norfolk, VA 23507, USA.
authors.forename: Banumathi K
authors.initials: BK
authors.lastname: Cole
authors.forename: David C
authors.initials: DC
authors.lastname: Lieb
authors.forename: Anca D
authors.initials: AD
authors.lastname: Dobrian
authors.forename: Jerry L
authors.initials: JL
authors.lastname: Nadler
mesh_terms: D050156:Adipogenesis; D000818:Animals; D001092:Arachidonate 12-Lipoxygenase / Q000378:metabolism*; D001093:Arachidonate 15-Lipoxygenase / Q000378:metabolism*; D016718:Arachidonic Acid / Q000378:metabolism*; D016207:Cytokines / Q000378:metabolism; D006801:Humans; D007249:Inflammation / Q000201:enzymology / Q000473:pathology; D050152:Intra-Abdominal Fat / Q000201:enzymology* / Q000473:pathology; D051379:Mice; D009765:Obesity / Q000201:enzymology* / Q000473:pathology; D015398:Signal Transduction
chemical_list: D016207:Cytokines; D016718:Arachidonic Acid; D001092:Arachidonate 12-Lipoxygenase; D001093:Arachidonate 15-Lipoxygenase