title: Fluorescent probes for sensing and imaging biological hydrogen sulfide.
abstract: Hydrogen sulfide (H(2)S) has long been recognized as a toxic molecule in biological systems. However, emerging studies now link controlled fluxes of this reactive sulfur species to cellular regulation and signaling events akin to other small molecule messengers, such as nitric oxide, hydrogen peroxide, and carbon monoxide. Progress in the development of fluorescent small-molecule indicators with high selectivity for hydrogen sulfide offers a promising approach for studying its production, trafficking, and downstream physiological and/or pathological effects.
authors.affiliation: Departments of Chemistry and Molecular and Cell Biology, University of California, Berkeley, CA 94720, USA.
authors.forename: Vivian S
authors.initials: VS
authors.lastname: Lin
authors.forename: Christopher J
authors.initials: CJ
authors.lastname: Chang
mesh_terms: D000818:Animals; D005456:Fluorescent Dyes / Q000032:analysis*; D006801:Humans; D006862:Hydrogen Sulfide / Q000032:analysis*; D057054:Molecular Imaging / Q000379:methods*; D061848:Optical Imaging / Q000379:methods*
chemical_list: D005456:Fluorescent Dyes; D006862:Hydrogen Sulfide