title: Relationship of insulin sensitivity, insulin secretion, and adiposity with insulin clearance in a multiethnic population: the insulin Resistance Atherosclerosis study.
abstract: OBJECTIVE
  We aimed to examine insulin clearance, a compensatory mechanism to changes in insulin sensitivity, across sex, race/ethnicity populations, and varying states of glucose tolerance.
  
  
  METHODS
  We measured insulin sensitivity index (S(I)), acute insulin response (AIR), and metabolic clearance rate of insulin (MCRI) by the frequently sampled intravenous glucose tolerance test in 1,295 participants in the Insulin Resistance Atherosclerosis Study.
  
  
  RESULTS
  MCRI was positively related to S(I) and negatively to AIR and adiposity across sex, race/ethnicity populations, and varying states of glucose tolerance, adiposity, and family history of diabetes. Differences in MCRI by race/ethnicity (lower in African Americans and Hispanics compared with non-Hispanic whites) and glucose tolerance were largely explained by differences in adiposity, S(I), and AIR.
  
  
  CONCLUSIONS
  Insulin sensitivity, insulin secretion, and adiposity are correlates of insulin clearance and appear to explain differences in insulin clearance by race/ethnicity and glucose tolerance status.
authors.affiliation: Department of Medicine, University of Texas Health Science Center, San Antonio, TX, USA. lorenzo@uthscsa.edu
authors.forename: Carlos
authors.initials: C
authors.lastname: Lorenzo
authors.forename: Anthony J G
authors.initials: AJ
authors.lastname: Hanley
authors.forename: Lynne E
authors.initials: LE
authors.lastname: Wagenknecht
authors.forename: Marian J
authors.initials: MJ
authors.lastname: Rewers
authors.forename: Darko
authors.initials: D
authors.lastname: Stefanovski
authors.forename: Mark O
authors.initials: MO
authors.lastname: Goodarzi
authors.forename: Steven M
authors.initials: SM
authors.lastname: Haffner
mesh_terms: D050154:Adiposity / Q000502:physiology*; D005260:Female; D018149:Glucose Intolerance / Q000378:metabolism; D006801:Humans; D007328:Insulin / Q000378:metabolism*; D007333:Insulin Resistance / Q000502:physiology*; D000078790:Insulin Secretion; D008297:Male; D008875:Middle Aged
chemical_list: D007328:Insulin