title: In vivo studies on the oridonin-loaded nanostructured lipid carriers.
abstract: Oridonin (ORI)-loaded Nanostructured lipid carriers (NLC) were prepared by emulsion-evaporation and low temperature-solidification technique, and evaluated for morphological observation, particle size, zeta potential and in vitro drug release. Next, the characteristics of biodistribution and pharmacokinetics in vivo were examined. The average particle size of resultant NLC was 245.2 nm and the zeta potential was found to be -38.77 mV. The in vivo characteristics of ORI-loaded NLC were studied after intravenous administration using Kunming strain mice as experimental animals. An ORI control solution was studied parallelly. In tested organs, the distribution of ORI-loaded NLC to liver was higher than that of free drug. ORI-loaded NLC showed higher AUC (area under tissue concentration-time curve) values and circulated in the blood stream for a longer time compared with ORI solution. These results support the potential applications of NLC for the delivery of ORI.
authors.affiliation: Department of Pharmaceutics, College of Pharmacy, Shandong University, Jinan, PR China.
authors.forename: Dandan
authors.initials: D
authors.lastname: Zheng
authors.forename: Wenting
authors.initials: W
authors.lastname: Dai
authors.forename: Dianrui
authors.initials: D
authors.lastname: Zhang
authors.forename: Cunxian
authors.initials: C
authors.lastname: Duan
authors.forename: Lejiao
authors.initials: L
authors.lastname: Jia
authors.forename: Yue
authors.initials: Y
authors.lastname: Liu
authors.forename: Qiang
authors.initials: Q
authors.lastname: Zhang
mesh_terms: D061605:Administration, Intravenous; D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000008:administration & dosage / Q000493:pharmacokinetics*; D019540:Area Under Curve; D045786:Diterpenes, Kaurane / Q000008:administration & dosage / Q000493:pharmacokinetics*; D016503:Drug Delivery Systems; D004655:Emulsions; D008055:Lipids / Q000737:chemistry*; D051379:Mice; D053758:Nanoparticles; D010316:Particle Size; D013696:Temperature; D014018:Tissue Distribution
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D045786:Diterpenes, Kaurane; D004655:Emulsions; D008055:Lipids; C011959:oridonin