title: Heterogeneity in the differentiation and function of memory B cells.
abstract: Vaccines that induce neutralizing antibodies have led to the eradication of small pox and have severely reduced the prevalence of many other infections. However, even the most successful vaccines do not induce protective antibodies in all individuals, and can fail to induce lifelong immunity. A key to remedying these shortcomings may lie in a better understanding of long-lived memory B cells. Recent studies have revealed novel insights into the differentiation and function of these cells, and have shown that the memory B cell pool is much more heterogeneous than previously appreciated.
authors.affiliation: Department of Microbiology, Center for Immunology, University of Minnesota Medical School, Minneapolis, MN 55455, USA.
authors.forename: Justin J
authors.initials: JJ
authors.lastname: Taylor
authors.forename: Marc K
authors.initials: MK
authors.lastname: Jenkins
authors.forename: Kathryn A
authors.initials: KA
authors.lastname: Pape
mesh_terms: D000818:Animals; D001402:B-Lymphocytes / Q000166:cytology / Q000276:immunology*; D002454:Cell Differentiation; D018858:Germinal Center / Q000166:cytology / Q000276:immunology; D006801:Humans; D007111:Immunity, Cellular; D007075:Immunoglobulin M / Q000276:immunology; D007156:Immunologic Memory
chemical_list: D007075:Immunoglobulin M