title: Expression of CD44v6 and Livin in gastric cancer tissue.
abstract: BACKGROUND
  CD44v6 plays an important role in invasion and metastasis of tumor, Livin has anti-apoptotic effects. The present study aimed to explore the expression and clinical significance of CD44v6 and Livin in gastric cancer tissue.
  
  
  METHODS
  Streptavidin-peroxidase linked immunohistochemical method was used to determine the expression of CD44v6 and Livin in gastric cancer tissue and adjacent normal gastric tissues from 59 patients with histopathologically confirmed gastric cancer, and in gastric tissue specimens of 15 patients with gastric polyps, and 15 patients with chronic non-atrophic gastritis. The chi-square test was used for comparison of the relevant factors, Spearman's rank correlation test was applied for relationship among positive expression of the proteins.
  
  
  RESULTS
  The expresion of CD44v6 was positive in 64.4% of the gastric cancer patients; 5.1%, 0 and 13.3% in specimens of normal tissues adjacent to the cancer tissues, in gastric tissue specimens of patients with gastric polyps, and patients with chronic non-atrophic gastritis, respectively. The expression of Livin was positive in 52.5% of the gastric cancer tissues, 6.8%, 0 and 6.7% in the adjacent normal gastric tissue, specimens of patients with gastric polyps and chronic non-atrophic gastritis, respectively. The expression of CD44v6 was significantly correlated with the depth of invasion, the degree of differentiation, and lymphnode metastasis of gastric cancer (P < 0.05). The positive expression rate of Livin protein was also significantly correlated with degree of differentiation of gastric cancer cells and metastasis to lymphnodes (P < 0.05), but not correlated with the depth of invasion and pathological types (P > 0.05). The expression of CD44v6 and Livin in the gastric cancer tissue was positively correlated (r(s) = 0.286, P = 0.028).
  
  
  CONCLUSIONS
  The increased expression of CD44v6 and Livin in gastric cancer tissue may be closely related with development and progression of gastric cancer. CD44v6 and Livin may be new biological markers of gastric cancer.
authors.affiliation: Department of Gastroenterology, Second Affiliated Hospital, Fujian Medical University, Quanzhou, Fujian 362000, China.
authors.forename: Yi-Zhi
authors.initials: YZ
authors.lastname: Liang
authors.forename: Tai-Yong
authors.initials: TY
authors.lastname: Fang
authors.forename: Hai-Gang
authors.initials: HG
authors.lastname: Xu
authors.forename: Zhi-Qiang
authors.initials: ZQ
authors.lastname: Zhuo
mesh_terms: D048868:Adaptor Proteins, Signal Transducing / Q000032:analysis* / Q000502:physiology; D000368:Aged; D005260:Female; D006801:Humans; D018960:Hyaluronan Receptors / Q000032:analysis* / Q000502:physiology; D007150:Immunohistochemistry; D051034:Inhibitor of Apoptosis Proteins / Q000032:analysis* / Q000502:physiology; D008297:Male; D008875:Middle Aged; D009363:Neoplasm Proteins / Q000032:analysis* / Q000502:physiology; D013274:Stomach Neoplasms / Q000737:chemistry* / Q000378:metabolism / Q000473:pathology
chemical_list: D048868:Adaptor Proteins, Signal Transducing; C419866:BIRC7 protein, human; C112697:CD44v6 antigen; D018960:Hyaluronan Receptors; D051034:Inhibitor of Apoptosis Proteins; D009363:Neoplasm Proteins