title: Synthesis, antifungal evaluation and molecular docking studies on 2- thioxoimidazolidin-4-one derivatives.
abstract: A series of 2-thioxoimidazolidin-4-one derivatives were synthesized and were characterized by IR, 1H NMR, 13C NMR, mass spectral data and elemental analysis. All compounds were tested for antifungal and antibacterial activity. Some of the compounds were found to exhibit promising antifungal activity. Molecular modeling investigations showed that the active compounds may interact at the active site of the fungal cytochrome P450- dependent sterol 14α- demethylase in the sterol biosynthesis pathway.
authors.affiliation: School of Pharmacy, Devi Ahilya Vishwavidyalaya, Indore, India. sudhaven01@gmail.com
authors.forename: Sudha
authors.initials: S
authors.lastname: Vengurlekar
authors.forename: Rajesh
authors.initials: R
authors.lastname: Sharma
authors.forename: Piyush
authors.initials: P
authors.lastname: Trivedi
mesh_terms: D000595:Amino Acid Sequence; D000935:Antifungal Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D020134:Catalytic Domain; D003198:Computer Simulation; D005658:Fungi / Q000187:drug effects*; D006801:Humans; D008958:Models, Molecular; D008969:Molecular Sequence Data; D011485:Protein Binding / Q000187:drug effects; D058886:Sterol 14-Demethylase / Q000138:chemical synthesis* / Q000737:chemistry* / Q000378:metabolism / Q000494:pharmacology
chemical_list: D000935:Antifungal Agents; D058886:Sterol 14-Demethylase