title: Guaiazulene: a new treatment option for recalcitrant diaper dermatitis in NICU patients.
abstract: OBJECTIVE
  Based on a maternal observation, we aimed to evaluate the treatment effectiveness of guaiazulene (GA) containing local pomade in the high-risk neonates with recalcitrant diaper dermatitis (RDD).
  
  
  METHODS
  We included 30 NICU patients of RDD, with level II-III aged between 22 and 67 days. Study group patients (n = 20) were treated with GA containing local pomade (0.05 g/100 g). Control group consisted of patients who had extended antifungal treatment. A visual scale was used to assess the response to treatment at the end of a week. Scoring was done at the beginning of the treatment, on the first, third and seventh days.
  
  
  RESULTS
  Statistically significant differences in visual scores were determined between the two groups at the initial and following days of the treatment. In study group, improvements at the first and third days of the treatment were better than those of control group. Additionally, complete recovery rate in study group was better than that in controls.
  
  
  CONCLUSIONS
  Having beneficial but no adverse effects, GA containing local pomade provided rapid recovery in risky neonates with RDD, who required rapid improvement.
authors.affiliation: Faculty of Medicine, Department of Pediatrics, Division of Neonatology, Erciyes University, Kayseri, Turkey.
authors.forename: Tamer
authors.initials: T
authors.lastname: Gunes
authors.forename: Mustafa Ali
authors.initials: MA
authors.lastname: Akin
authors.forename: Dilek
authors.initials: D
authors.lastname: Sarici
authors.forename: Kurtulus
authors.initials: K
authors.lastname: Hallac
authors.forename: Selim
authors.initials: S
authors.lastname: Kurtoglu
authors.forename: Takashi
authors.initials: T
authors.lastname: Hashimoto
mesh_terms: D000328:Adult; D052176:Azulenes / Q000627:therapeutic use*; D003963:Diaper Rash / Q000188:drug therapy*; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007234:Infant, Premature; D007235:Infant, Premature, Diseases / Q000188:drug therapy*; D007363:Intensive Care Units, Neonatal; D015931:Intensive Care, Neonatal / Q000379:methods*; D008297:Male; D011446:Prospective Studies; D012717:Sesquiterpenes / Q000627:therapeutic use*; D045789:Sesquiterpenes, Guaiane
chemical_list: D052176:Azulenes; D012717:Sesquiterpenes; D045789:Sesquiterpenes, Guaiane; C004451:guaiazulene