title: Yersinia pestis and approaches to targeting its outer protein H protein-tyrosine phosphatase (YopH).
abstract: Plague is an infectious disease with a high mortality rate that has repeatedly impacted human society. It remains a threat in many parts of the world today. Plague is caused by the bacterium, Yersinia pestis (Y. pestis), which has as one of its required virulence factors, the protein-tyrosine phosphatase, YopH. Therefore, YopH represents a potential target for the treatment of Y. pestis infection. Recent recognition of Y. pestis as a possible bioterrorism agent and the fact that it is still the cause of endemic disease around the world make it an important object of study and heighten the need for new anti-plague agents. The current review covers aspects of plague and its historical occurrence and summarizes approaches to developing YopH inhibitors.
authors.affiliation: Chemical Biology Laboratory, Frederick National Laboratory for Cancer Research, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Frederick, MD 21702, U.S.A.
authors.forename: M
authors.initials: M
authors.lastname: Bahta
authors.forename: T R
authors.initials: TR
authors.lastname: Burke
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry* / Q000494:pharmacology*; D001425:Bacterial Outer Membrane Proteins / Q000037:antagonists & inhibitors* / Q000737:chemistry / Q000378:metabolism; D055808:Drug Discovery; D049672:History, 19th Century; D049673:History, 20th Century; D049674:History, 21st Century; D049691:History, Medieval; D006801:Humans; D008958:Models, Molecular; D010930:Plague / Q000188:drug therapy* / Q000266:history / Q000382:microbiology; D017027:Protein Tyrosine Phosphatases / Q000037:antagonists & inhibitors* / Q000737:chemistry / Q000378:metabolism; D054852:Small Molecule Libraries / Q000737:chemistry / Q000494:pharmacology; D037521:Virulence Factors / Q000037:antagonists & inhibitors* / Q000737:chemistry / Q000378:metabolism; D015010:Yersinia pestis / Q000737:chemistry / Q000187:drug effects / Q000201:enzymology*
chemical_list: D000900:Anti-Bacterial Agents; D001425:Bacterial Outer Membrane Proteins; D054852:Small Molecule Libraries; D037521:Virulence Factors; D017027:Protein Tyrosine Phosphatases; C067571:yopH protein, Yersinia