title: Matrix metalloproteinase-9 (MMP-9) and myeloperoxidase (MPO) levels in patients with nonobstructive coronary artery disease detected by coronary computed tomographic angiography.
abstract: OBJECTIVE
  The aim of this study was to evaluate whether matrix metalloproteinase-9 (MMP-9) and myeloperoxidase (MPO) are elevated in patients with nonobstructive coronary artery disease.
  
  
  METHODS
  Eighty-four patients with nonobstructive coronary artery disease (group A) and 90 patients with no coronary plaques (group B) were enrolled. MMP-9 and MPO levels were compared between the two groups. The relationships between these biomarkers and Framingham risk score were analyzed. Receiver-operating characteristic curves were used to evaluate the ability of these biomarkers to predict the presence of coronary artery plaques.
  
  
  RESULTS
  The MMP-9 and MPO values in group A were significantly higher than in group B (P < .001). The levels of MMP-9 and MPO showed significant correlations with Framingham risk score (r = 0.796, P < .001, and r = 0.409, P < .001, respectively). The areas under the receiver-operating characteristic curves for MMP-9 and MPO were 0.80 (95% confidence interval, 0.74-0.87) and 0.74 (95% confidence interval, 0.66-0.81), respectively.
  
  
  CONCLUSIONS
  Levels of MMP-9 and MPO are positively correlated with Framingham risk score. Additionally, in patients with nonobstructive coronary artery disease, elevated levels of MMP-9 and MPO may identify patients at risk for future myocardial infarction or sudden cardiac death.
authors.affiliation: Department of Radiology, Cardiovascular Institute and Fu Wai Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, Xi-Cheng District, Beijing, China.
authors.forename: Zhi-Hui
authors.initials: ZH
authors.lastname: Hou
authors.forename: Bin
authors.initials: B
authors.lastname: Lu
authors.forename: Yang
authors.initials: Y
authors.lastname: Gao
authors.forename: Hui-Li
authors.initials: HL
authors.lastname: Cao
authors.forename: Fang-Fang
authors.initials: FF
authors.lastname: Yu
authors.forename: Na
authors.initials: N
authors.lastname: Jing
authors.forename: Xi
authors.initials: X
authors.lastname: Chen
authors.forename: Xiang-Feng
authors.initials: XF
authors.lastname: Cong
authors.forename: Sion K
authors.initials: SK
authors.lastname: Roy
authors.forename: Matthew J
authors.initials: MJ
authors.lastname: Budoff
mesh_terms: D015415:Biomarkers; D003287:Contrast Media; D017023:Coronary Angiography; D003324:Coronary Artery Disease / Q000000981:diagnostic imaging* / Q000378:metabolism*; D005260:Female; D006801:Humans; D007472:Iohexol / Q000031:analogs & derivatives; D008297:Male; D020780:Matrix Metalloproteinase 9 / Q000378:metabolism*; D008875:Middle Aged; D009195:Peroxidase / Q000378:metabolism*; D011237:Predictive Value of Tests; D012372:ROC Curve; D012189:Retrospective Studies; D018570:Risk Assessment; D012307:Risk Factors; D012680:Sensitivity and Specificity; D014057:Tomography, X-Ray Computed
chemical_list: D015415:Biomarkers; D003287:Contrast Media; D007472:Iohexol; C038192:iopromide; D009195:Peroxidase; D020780:Matrix Metalloproteinase 9