title: X-ray imaging of tumor growth in live mice by detecting gold-nanoparticle-loaded cells.
abstract: We show that sufficient concentrations of gold nanoparticles produced by an original synthesis method in EMT-6 and CT-26 cancer cells make it possible to detect the presence, necrosis and proliferation of such cells after inoculation in live mice. We first demonstrated that the nanoparticles do not interfere with the proliferation process. Then, we observed significant differences in the tumor evolution and the angiogenesis process after shallow and deep inoculation. A direct comparison with pathology optical images illustrates the effectiveness of this approach.
authors.affiliation: Institute of Physics, Academia Sinica, Nankang, Taipei 115, Taiwan.
authors.forename: Chia-Chi
authors.initials: CC
authors.lastname: Chien
authors.forename: Hsiang-Hsin
authors.initials: HH
authors.lastname: Chen
authors.forename: Sheng-Feng
authors.initials: SF
authors.lastname: Lai
authors.forename: Y
authors.initials: Y
authors.lastname: Hwu
authors.forename: Cyril
authors.initials: C
authors.lastname: Petibois
authors.forename: C S
authors.initials: CS
authors.lastname: Yang
authors.forename: Y
authors.initials: Y
authors.lastname: Chu
authors.forename: G
authors.initials: G
authors.lastname: Margaritondo
mesh_terms: D000818:Animals; D045744:Cell Line, Tumor; D058948:Cell Tracking / Q000379:methods*; D006046:Gold; D053768:Metal Nanoparticles / Q000737:chemistry; D051379:Mice; D008807:Mice, Inbred BALB C; D009369:Neoplasms / Q000000981:diagnostic imaging*; D011859:Radiography
chemical_list: D006046:Gold