title: New frontiers in the design and synthesis of imaging probes for PET oncology: current challenges and future directions.
abstract: Despite being developed over 30 years ago, 2-deoxy-2-[(18)F]fluoro-D-glucose remains the most frequently used radiotracer in PET oncology. In the last decade, interest in new and more specific radiotracers for imaging biological processes of oncologic interest has increased exponentially. This review summarizes the strategies underlying the development of those probes together with their validation and status of clinical translation; a brief summary of new radiochemistry strategies applicable to PET imaging is also included. The article finishes with a consideration of the challenges imaging scientists must overcome to bring about increased adoption of PET as a diagnostic or pharmacologic tool.
authors.affiliation: Post-Graduate Medical Institute, University of Hull, Cottingham Road, Hull, HU6 7RX, UK.
authors.forename: Graham
authors.initials: G
authors.lastname: Smith
authors.forename: Laurence
authors.initials: L
authors.lastname: Carroll
authors.forename: Eric O
authors.initials: EO
authors.lastname: Aboagye
mesh_terms: D000818:Animals; D017209:Apoptosis; D049109:Cell Proliferation; D006801:Humans; D057054:Molecular Imaging / Q000379:methods*; D015335:Molecular Probes / Q000138:chemical synthesis* / Q000737:chemistry*; D009369:Neoplasms / Q000098:blood supply / Q000175:diagnosis / Q000473:pathology; D049268:Positron-Emission Tomography / Q000379:methods* / Q000639:trends*
chemical_list: D015335:Molecular Probes