title: Determination of carcinoembryonic antigen and cancer antigen (CA 15-3) in bitches with tumours on mammary gland: preliminary report.
abstract: The aim of this work was to determine levels of carcinoembryonic antigen (CEA) and cancer antigen (CA 15-3) in the blood serum of 45 bitches. A modified procedure was used to determine the CEA and CA 15-3 markers with the human kits using the radioimmunoassay method. Samples collected from extirpated tumour of mammary glands were histologically processed and classified as per WHO guidelines. The average age of animals with tumour was 10.00 ± 2.2 years; for healthy bitches average age was 4.2 ± 3.2 years. Values of CEA and CA 15-3 were considered positive, if they exceeded 0.23 ng mL(-1) and 7 IU mL(-1) , respectively. Average levels of CEA in the tumour group were 0.25 ± 0.06 versus 0.20 ± 0.03 in healthy bitches (P = 0.0001). The average CA 15-3 value in bitches with tumour was 8.58 ± 1.27 versus 5.14 ± 1.34 in healthy animals (P < 0.0001).
authors.affiliation: Small Animal Clinic, University of Veterinary Medicine and Pharmacy, Komenskeho 73, Kosice, Slovakia.
authors.forename: A
authors.initials: A
authors.lastname: Valencakova-Agyagosova
authors.forename: Z
authors.initials: Z
authors.lastname: Frischova
authors.forename: Z
authors.initials: Z
authors.lastname: Sevcikova
authors.forename: J
authors.initials: J
authors.lastname: Hajurka
authors.forename: J
authors.initials: J
authors.lastname: Lepej
authors.forename: I
authors.initials: I
authors.lastname: Szakallova
authors.forename: G
authors.initials: G
authors.lastname: Kredatusova
authors.forename: V
authors.initials: V
authors.lastname: Nagy
authors.forename: V
authors.initials: V
authors.lastname: Ledecky
mesh_terms: D000818:Animals; D014408:Biomarkers, Tumor / Q000235:genetics / Q000378:metabolism; D002272:Carcinoembryonic Antigen / Q000235:genetics / Q000378:metabolism*; D004283:Dog Diseases / Q000235:genetics / Q000378:metabolism*; D004285:Dogs; D005260:Female; D015972:Gene Expression Regulation, Neoplastic / Q000502:physiology; D015674:Mammary Neoplasms, Animal / Q000235:genetics / Q000378:metabolism*; D018396:Mucin-1 / Q000235:genetics / Q000378:metabolism*
chemical_list: D014408:Biomarkers, Tumor; D002272:Carcinoembryonic Antigen; D018396:Mucin-1