title: Correlation between IL-7 and MCP-1 in diabetic chronic non healing ulcer patients at higher risk of coronary artery disease.
abstract: Cytokines play an extremely important role in the pathogenesis of coronary artery disease (CAD) in which interleukin (IL)-7 is a major regulator of T-cell homeostasis which is conced in the stimulation of leukocyte-endothelial cell adhesion during inflammatory events. Circulating IL-7 is associated with activation of monocyte and natural killer cells, leading to enhanced production of inflammatory cytokines and chemokines observed in atherosclerosis and acute coronary syndromes. Plasma levels of IL-7, hs-CRP and monocyte chemoattractant protein (MCP)-1 were measured by an immunoenzymatic ELISA technique. Ninety neuropathic diabetic foot patients were divided into two groups: group B [those without CAD (n=45)] and group C [those with higher risk of CAD (n=45)]. Thirty-five healthy subjects were included as control (group H). Plasma concentration of IL-7, MCP-1 and hs-CRP were significantly higher in group C as compare with group H and B. Plasma IL-7 levels also showed significant positive correlations with plasma levels of hs-CRP and MCP-1. Abnormalities in lipid profile were also observed. In conclusion the positive correlation between plasma concentration of IL-7, MCP-1 and hs-CRP in diabetic foot patients observed herein, suggests a plausible role for IL-7 in the promotion of clinical instability in coronary artery disease.
authors.affiliation: Department of Medicine, Institute of Medical Sciences, Banaras Hindu University, Varanasi, India.
authors.forename: Awadhesh K
authors.initials: AK
authors.lastname: Arya
authors.forename: Deepa
authors.initials: D
authors.lastname: Pokharia
authors.forename: Surya
authors.initials: S
authors.lastname: Bhan
authors.forename: Richik
authors.initials: R
authors.lastname: Tripathi
authors.forename: Kamlakar
authors.initials: K
authors.lastname: Tripathi
mesh_terms: D002097:C-Reactive Protein / Q000032:analysis; D002448:Cell Adhesion / Q000276:immunology; D018932:Chemokine CCL2 / Q000097:blood*; D018925:Chemokines / Q000097:blood; D003324:Coronary Artery Disease / Q000097:blood* / Q000276:immunology / Q000378:metabolism; D016207:Cytokines / Q000097:blood; D003920:Diabetes Mellitus / Q000276:immunology / Q000378:metabolism; D017719:Diabetic Foot / Q000097:blood* / Q000276:immunology / Q000378:metabolism; D042783:Endothelial Cells / Q000378:metabolism; D005260:Female; D006801:Humans; D015851:Interleukin-7 / Q000097:blood*; D007694:Killer Cells, Natural / Q000276:immunology; D007962:Leukocytes / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D009000:Monocytes / Q000276:immunology; D014456:Ulcer / Q000276:immunology / Q000378:metabolism
chemical_list: C111835:CCL2 protein, human; D018932:Chemokine CCL2; D018925:Chemokines; D016207:Cytokines; D015851:Interleukin-7; D002097:C-Reactive Protein