title: ADAM23, a Gene Related to LGI1, Is Not Linked to Autosomal Dominant Lateral Temporal Epilepsy.
abstract: Autosomal dominant lateral temporal epilepsy (ADTLE) is an inherited epileptic syndrome characterized by ictal auditory symptoms or aphasia, negative MRI findings, and relatively benign evolution. Mutations responsible for ADLTE have been found in the LGI1 gene. The functions of the Lgi1 protein apparently are mediated by interactions with members of the ADAM protein family: it binds the postsynaptic receptor ADAM22 to regulate glutamate-AMPA currents at excitatory synapses and also the ADAM23 receptor to promote neurite outgrowth in vitro and dendritic arborization in vivo. Because alteration of each of these neuronal mechanisms may underlie ADLTE, ADAM22 and ADAM23 are candidate genes for this syndrome. In a previous work, we excluded a major role of ADAM22 in the aetiology of ADLTE. Here, we performed linkage analysis between microsatellite markers within or flanking the ADAM23 gene and ADLTE in 13 Italian families. The results exclude ADAM23 as major causative gene for ADLTE.
authors.affiliation: CNR-Institute of Neurosciences, Section of Padua, Department of Experimental Biomedical Sciences, University of Padua, viale G. Colombo 3, 35121 Padova, Italy.
authors.forename: Laura
authors.initials: L
authors.lastname: Rigon
authors.forename: Andrea
authors.initials: A
authors.lastname: Vettori
authors.forename: Giorgia
authors.initials: G
authors.lastname: Busolin
authors.forename: Gabriella
authors.initials: G
authors.lastname: Egeo
authors.forename: Patrizia
authors.initials: P
authors.lastname: Pulitano
authors.forename: Lia
authors.initials: L
authors.lastname: Santulli
authors.forename: Elena
authors.initials: E
authors.lastname: Pasini
authors.forename: Pasquale
authors.initials: P
authors.lastname: Striano
authors.forename: Angela
authors.initials: A
authors.lastname: la Neve
authors.forename: Valeria
authors.initials: V
authors.lastname: Vianello Dri
authors.forename: Clementina
authors.initials: C
authors.lastname: Boniver
authors.forename: Antonio
authors.initials: A
authors.lastname: Gambardella
authors.forename: Paola
authors.initials: P
authors.lastname: Banfi
authors.forename: Simona
authors.initials: S
authors.lastname: Binelli
authors.forename: Carlo
authors.initials: C
authors.lastname: Di Bonaventura
authors.forename: Salvatore
authors.initials: S
authors.lastname: Striano
authors.forename: Fabrizio
authors.initials: F
authors.lastname: de Falco
authors.forename: Anna T
authors.initials: AT
authors.lastname: Giallonardo
authors.forename: Oriano
authors.initials: O
authors.lastname: Mecarelli
authors.forename: Roberto
authors.initials: R
authors.lastname: Michelucci
authors.forename: Carlo
authors.initials: C
authors.lastname: Nobile