title: Drug interactions: a primer for the gastroenterologist.
abstract: One of the most clinically significant complications related to the use of pharmacotherapy is the potential for drug-drug or drug-disease interactions. The gastrointestinal system plays a large role in the pharmacokinetic profile of most medications, and many medications utilized in gastroenterology have clinically significant drug interactions. This review will discuss the impact of alterations of intestinal pH, interactions mediated by phase I hepatic metabolism enzymes and P-glycoprotein, the impact of liver disease on drug metabolism, and interactions seen with commonly utilized gastrointestinal medications.
authors.affiliation: Dr. Doligalski, Dr. Tong Logan, and Dr. Silverman are all Solid Organ Transplant Pharmacotherapy Specialists at Tampa General Hospital in Tampa, Florida.
authors.forename: Christina Teeter
authors.initials: CT
authors.lastname: Doligalski
authors.forename: Angela
authors.initials: A
authors.lastname: Tong Logan
authors.forename: Andrew
authors.initials: A
authors.lastname: Silverman