title: Sparse reconstruction for bioluminescence tomography based on the semigreedy method.
abstract: Bioluminescence tomography (BLT) is a molecular imaging modality which can three-dimensionally resolve the molecular processes in small animals in vivo. The ill-posedness nature of BLT problem makes its reconstruction bears nonunique solution and is sensitive to noise. In this paper, we proposed a sparse BLT reconstruction algorithm based on semigreedy method. To reduce the ill-posedness and computational cost, the optimal permissible source region was automatically chosen by using an iterative search tree. The proposed method obtained fast and stable source reconstruction from the whole body and imposed constraint without using a regularization penalty term. Numerical simulations on a mouse atlas, and in vivo mouse experiments were conducted to validate the effectiveness and potential of the method.
authors.affiliation: The College of Electronic Information & Control Engineering, Beijing University of Technology, Beijing 100124, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Guo
authors.forename: Kebin
authors.initials: K
authors.lastname: Jia
authors.forename: Qian
authors.initials: Q
authors.lastname: Zhang
authors.forename: Xueyan
authors.initials: X
authors.lastname: Liu
authors.forename: Jinchao
authors.initials: J
authors.lastname: Feng
authors.forename: Chenghu
authors.initials: C
authors.lastname: Qin
authors.forename: Xibo
authors.initials: X
authors.lastname: Ma
authors.forename: Xin
authors.initials: X
authors.lastname: Yang
authors.forename: Jie
authors.initials: J
authors.lastname: Tian
mesh_terms: D000465:Algorithms; D000818:Animals; D019295:Computational Biology / Q000379:methods*; D003198:Computer Simulation; D003952:Diagnostic Imaging / Q000379:methods*; D007091:Image Processing, Computer-Assisted / Q000379:methods*; D008027:Light; D049449:Luminescence; D051379:Mice; D008954:Models, Biological; D008962:Models, Theoretical; D055095:Optics and Photonics; D017785:Photons; D014054:Tomography / Q000379:methods*; D055114:X-Ray Microtomography / Q000379:methods*