title: The assessment of retinal nerve fiber layer thickness changing after glaucoma surgery by optical coherence tomography, Phramongkutklao Hospial.
abstract: OBJECTIVE
  To assess retinal nerve fiber (RNFL) thickness change in glaucoma patients after glaucoma surgery.
  
  
  METHODS
  A prospective and cohort study of 19 patients who underwent trabeculectomy with mitomicin C or combined procedures or glaucoma drainage device surgery in Phramongkutklao Hospital were included. All subjects had obtained informed consents. Preoperative and 3 month-postoperative IOP and RNFL thickness were determined. Areas of peripapilllary RNFL thickness were evaluated by Stratus OCT scanning. The relationship between IOP reduction and RNFL thickness change after glaucoma surgery was analyzed.
  
  
  RESULTS
  Postoperative RNFL thickness analysis found no significant increase in inferior, superior, nasal and temporal quadrants. The average of preoperative RNFL thickness was 59.58 +/- 17.59 microns, whereas the average of postoperative RNFL thickness was 57.19 +/- 14.97 microns (p = 0.426). Postoperative IOP was decreased significantly from 29.26 +/- 8.58 mmHg to 12.11 +/- 4.52 mmHq (p < 0.001). The mean of postoperative RNFL thickness was not significantly correlated with IOP reduction (r = 0.306, p = 0.250).
  
  
  CONCLUSIONS
  Post glaucoma surgery, RNFL thickness was not significantly increased although the IOP had significantly reduced. No correlation between IOP reduction and RNFL thickness was found.
authors.affiliation: Department of Ophthalmology, Phramongkutklao Hospital, Bangkok, Thailand.
authors.forename: Sitthinee
authors.initials: S
authors.lastname: Maneesang
authors.forename: Ornwasee
authors.initials: O
authors.lastname: Jatutong
authors.forename: Wallop
authors.initials: W
authors.lastname: Iemsomboon
mesh_terms: D005260:Female; D005901:Glaucoma / Q000601:surgery*; D006801:Humans; D007429:Intraocular Pressure; D008297:Male; D008875:Middle Aged; D009412:Nerve Fibers / Q000648:ultrastructure*; D011446:Prospective Studies; D055351:Retinal Neurons / Q000648:ultrastructure*; D013785:Thailand; D041623:Tomography, Optical Coherence