title: Clozapine as a potential treatment for refractory impulsive, compulsive, and punding behaviors in Parkinson's disease.
abstract: There have been emerging cases of medication refractory obsessions, impulsivity, compulsivity, and/or punding in Parkinson's disease. These cases have proven difficult to treat, even for the experienced clinician. We report several medication refractory cases with a positive response to treatment with clozapine.
authors.affiliation: a Department of Neurology , Center for Movement Disorders & Neurorestoration , Gainesville , FL , USA.
authors.forename: A
authors.initials: A
authors.lastname: Hardwick
authors.forename: H
authors.initials: H
authors.lastname: Ward
authors.forename: A
authors.initials: A
authors.lastname: Hassan
authors.forename: J
authors.initials: J
authors.lastname: Romrell
authors.forename: M S
authors.initials: MS
authors.lastname: Okun
mesh_terms: D000328:Adult; D000368:Aged; D014150:Antipsychotic Agents / Q000627:therapeutic use*; D003024:Clozapine / Q000627:therapeutic use*; D003192:Compulsive Behavior / Q000188:drug therapy* / Q000209:etiology; D006801:Humans; D007175:Impulsive Behavior / Q000188:drug therapy* / Q000209:etiology; D008297:Male; D008875:Middle Aged; D010300:Parkinson Disease / Q000150:complications*; D016896:Treatment Outcome
chemical_list: D014150:Antipsychotic Agents; D003024:Clozapine