title: Impact of smoking and smoking cessation on oncologic outcomes in primary non-muscle-invasive bladder cancer.
abstract: BACKGROUND
  Cigarette smoking is the best-established risk factor for urothelial carcinoma (UC) development, but the impact on oncologic outcomes remains poorly understood.
  
  
  OBJECTIVE
  To analyse the effects of smoking status, cumulative exposure, and time from smoking cessation on the prognosis of patients with primary non-muscle-invasive bladder cancer (NMIBC).
  
  
  METHODS
  We collected smoking data from 2043 patients with primary NMIBC. Smoking variables included smoking status, average number of cigarettes smoked per day (CPD), duration in years, and time since smoking cessation. Lifetime cumulative smoking exposure was categorised as light short term (≤ 19 CPD, ≤ 19.9 yr), light long term (≤ 19 CPD, ≥ 20 yr), heavy short term (≥ 20 CPD, ≤ 19.9 yr) and heavy long term (≥ 20 CPD, ≥ 20 yr). The median follow-up in this retrospective study was 49 mo.
  
  
  METHODS
  Transurethral resection of the bladder with or without intravesical instillation therapy.
  
  
  METHODS
  Univariable and multivariable logistic regression and competing risk regression analyses assessed the effects of smoking on outcomes.
  
  
  CONCLUSIONS
  There was no difference in clinicopathologic factors among never (24%), former (47%), and current smokers (29%). Smoking status was associated with the cumulative incidence of disease progression in multivariable analysis (p=0.003); current smokers had the highest cumulative incidences. Among current and former smokers, cumulative smoking exposure was associated with disease recurrence (p<0.001), progression (p<0.001), and overall survival (p<0.001) in multivariable analyses that adjusted for the effects of standard clinicopathologic factors and smoking status; heavy long-term smokers had the worst outcomes, followed by light long-term, heavy short-term, and light short-term smokers. Smoking cessation >10 yr reduced the risk of disease recurrence (hazard ratio [HR]: 0.66; 95% confidence interval [CI], 0.52-0.84; p<0.001) and progression (HR: 0.42; 95% CI, 0.22-0.83; p=0.036) in multivariable analyses. The study is limited by its retrospective nature.
  
  
  CONCLUSIONS
  Smoking status and a higher cumulative smoking exposure are associated with worse prognosis in patients with NMIBC. Smoking cessation >10 yr abrogates this detrimental effect. These findings underscore the need for integrated smoking cessation and prevention programmes in the management of NMIBC patients.
authors.affiliation: Department of Urology, Weill Cornell Medical College, New York Presbyterian Hospital, New York, NY 10065, USA.
authors.forename: Michael
authors.initials: M
authors.lastname: Rink
authors.forename: Helena
authors.initials: H
authors.lastname: Furberg
authors.forename: Emily C
authors.initials: EC
authors.lastname: Zabor
authors.forename: Evanguelos
authors.initials: E
authors.lastname: Xylinas
authors.forename: Marko
authors.initials: M
authors.lastname: Babjuk
authors.forename: Armin
authors.initials: A
authors.lastname: Pycha
authors.forename: Yair
authors.initials: Y
authors.lastname: Lotan
authors.forename: Pierre I
authors.initials: PI
authors.lastname: Karakiewicz
authors.forename: Giacomo
authors.initials: G
authors.lastname: Novara
authors.forename: Brian D
authors.initials: BD
authors.lastname: Robinson
authors.forename: Francesco
authors.initials: F
authors.lastname: Montorsi
authors.forename: Felix K
authors.initials: FK
authors.lastname: Chun
authors.forename: Douglas S
authors.initials: DS
authors.lastname: Scherr
authors.forename: Shahrokh F
authors.initials: SF
authors.lastname: Shariat
mesh_terms: D000283:Administration, Intravesical; D000368:Aged; D015653:Cystectomy / Q000379:methods*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000453:epidemiology* / Q000401:mortality; D011379:Prognosis; D012189:Retrospective Studies; D012307:Risk Factors; D012907:Smoking / Q000009:adverse effects* / Q000453:epidemiology; D016540:Smoking Cessation / Q000379:methods*; D016896:Treatment Outcome; D001749:Urinary Bladder Neoplasms / Q000188:drug therapy* / Q000601:surgery