title: A dedicated clinic for HIV-positive individuals over 50 years of age: a multidisciplinary experience.
abstract: The HIV-infected population is ageing. Issues including polypharmacy and co-morbidities led us to develop a dedicated clinic for HIV-infected individuals over 50. We describe our service evaluation after two years. The over 50 clinic commenced in January 2009. The team comprises a registrar, consultant, nurse practitioner and is supported by a pharmacist and mental health services. Patients undergo a full medication and drug interactions review, neurocognitive assessment, adherence self-assessment and investigations including therapeutic drug monitoring (TDM), coronary artery calcium scores (CACS) and bone mineral density. Over two years of activity, 150 patients attended the service. Median (range) age was 58 (50-88), all were on combined antiretroviral therapy and 38% (57/150) were on ≥3 non-HIV drugs. CACS was high (>90th centile) in 14%. Thirty-eight percent had osteopaenia and 18% had osteoporosis requiring treatment. Thirteen out of 125 men had an increased prostate specific antigen, four were diagnosed with prostate cancer. Drug interaction, TDM and neurocognitive assessments were useful for several patients. Asymptomatic patients over 50 in long-term follow-up had new pathologies detected through targeted screening. The clinic has improved general practitioner (GP) liaison and facilitated closer working relationships with other specialties. Patients have reacted positively to the clinic, particularly as many do not routinely access their GP.
authors.affiliation: Department of GU/HIV Medicine, Chelsea & Westminster Hospital, London, UK. lwaters@nhs.net
authors.forename: L
authors.initials: L
authors.lastname: Waters
authors.forename: B
authors.initials: B
authors.lastname: Patterson
authors.forename: A
authors.initials: A
authors.lastname: Scourfield
authors.forename: A
authors.initials: A
authors.lastname: Hughes
authors.forename: S
authors.initials: S
authors.lastname: de Silva
authors.forename: B
authors.initials: B
authors.lastname: Gazzard
authors.forename: S
authors.initials: S
authors.lastname: Barton
authors.forename: D
authors.initials: D
authors.lastname: Asboe
authors.forename: A
authors.initials: A
authors.lastname: Pozniak
authors.forename: M
authors.initials: M
authors.lastname: Boffito
mesh_terms: D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D000554:Ambulatory Care Facilities / Q000458:organization & administration*; D019380:Anti-HIV Agents / Q000009:adverse effects / Q000627:therapeutic use; D015519:Bone Density; D004347:Drug Interactions; D005260:Female; D006679:HIV Seropositivity / Q000150:complications / Q000188:drug therapy / Q000628:therapy*; D006801:Humans; D008131:London; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests; D010348:Patient Care Team
chemical_list: D019380:Anti-HIV Agents