title: CML Developing Three Years after Therapy Completion in a Child with Ph(-) Pre-B-ALL.
abstract: We report a girl with a history of Ph(-) pre-B-ALL and three years of disease-free survival admitting to our hospital for regular end of treatment checkup with an increased white blood cell count which in follow-up studies and molecular detection of BCR-ABL (p210) fusions gene had been diagnosed as a Ph(+) typical CML. The upcoming question in this case scenario is whether developed CML is a secondary leukemia due to previous ALL chemotherapy or just a relapse case of primary leukemia.
authors.affiliation: Hematology Laboratory, Hematology Oncology Ward, Ali Asghar Children Hospital, Tehran, Iran.
authors.forename: S
authors.initials: S
authors.lastname: Hosseini
authors.forename: G H
authors.initials: GH
authors.lastname: Bahoush
authors.forename: P
authors.initials: P
authors.lastname: Vousogh
authors.forename: Sh
authors.initials: Sh
authors.lastname: Ansari
authors.forename: Kh
authors.initials: Kh
authors.lastname: Arjmandi
authors.forename: M
authors.initials: M
authors.lastname: Sabzechian