title: Spiro-fused pyrrolidine, piperidine, and oxindole scaffolds from lactams.
abstract: Expedient routes to three classes of novel spiro-fused pyrrolidine, piperidine, and indoline heterocycle scaffolds are described. These three-dimensional frameworks, which conform to the "rule of three", are suitably protected to allow for site-selective manipulation and functionalization. Different modes of substrate control were explored, which allow for good to excellent levels of diastereoselectivity and dispense with the need for additional chiral reagents or catalysts. The concepts developed were applied in short, formal syntheses of (±)-coerulescine and (±)-horsfiline.
authors.affiliation: School of Chemistry, University of Bristol , Bristol, BS8 1TS, UK.
authors.forename: Christoph
authors.initials: C
authors.lastname: Hirschhäuser
authors.forename: Jeremy S
authors.initials: JS
authors.lastname: Parker
authors.forename: Matthew W D
authors.initials: MW
authors.lastname: Perry
authors.forename: Mairi F
authors.initials: MF
authors.lastname: Haddow
authors.forename: Timothy
authors.initials: T
authors.lastname: Gallagher
mesh_terms: D000814:Aniline Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D002384:Catalysis; D007211:Indoles / Q000138:chemical synthesis* / Q000737:chemistry; D007769:Lactams / Q000737:chemistry*; D015394:Molecular Structure; D000078183:Oxindoles; D010880:Piperidines / Q000138:chemical synthesis* / Q000737:chemistry; D011759:Pyrrolidines / Q000138:chemical synthesis* / Q000737:chemistry; D013141:Spiro Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D013237:Stereoisomerism
chemical_list: D000814:Aniline Compounds; D007211:Indoles; D007769:Lactams; D000078183:Oxindoles; D010880:Piperidines; D011759:Pyrrolidines; D013141:Spiro Compounds; C480174:coerulescine; C443722:horsfiline; C022960:2-oxindole; C032727:piperidine; C032519:pyrrolidine