title: Total synthesis of laetevirenol A.
abstract: The first complete synthesis of laetevirenol A was performed in nine steps via intramolecular Friedel-Crafts alkylation in a trans-selective manner. The key phenanthrene intermediate was synthesized by a one-pot Suzuki-Miyaura coupling and an aldol condensation cascade reaction.
authors.affiliation: Medicinal Chemistry Research Center, Korea Research Institute of Chemical Technology, 141 Gajeong-ro, Daejeon 305-600, Korea.
authors.forename: Young Lok
authors.initials: YL
authors.lastname: Choi
authors.forename: Bum Tae
authors.initials: BT
authors.lastname: Kim
authors.forename: Jung-Nyoung
authors.initials: JN
authors.lastname: Heo
mesh_terms: D000478:Alkylation; D002384:Catalysis; D015394:Molecular Structure; D010616:Phenanthrenes / Q000138:chemical synthesis* / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D010616:Phenanthrenes; C578544:laetevirenol A; C031181:phenanthrene