title: Modification of one epitope-flanking amino acid allows for the induction of friend retrovirus-specific CD8+ T cells by Adenovirus-based immunization.
abstract: While Friend retrovirus-infected mice readily mount a vigorous CD8(+) T cell response to the leader-gag-derived peptide GagL(85-93), no GagL(85-93)-specific T cells were detectable in mice immunized against Friend virus (FV) with viral vectors or DNA vaccines. By exchanging one epitope-flanking amino acid or using a scaffold protein we were able to demonstrate for the first time the induction of GagL(85-93)-specific CD8(+) T cells by genetic vaccination and show their high protective effect against FV challenge infection.
authors.affiliation: Institute for Virology, University Hospital Essen, University Duisburg-Essen, Essen, Germany.
authors.forename: Philipp
authors.initials: P
authors.lastname: Gödel
authors.forename: Sonja
authors.initials: S
authors.lastname: Windmann
authors.forename: Kirsten K
authors.initials: KK
authors.lastname: Dietze
authors.forename: Ulf
authors.initials: U
authors.lastname: Dittmer
authors.forename: Wibke
authors.initials: W
authors.lastname: Bayer
mesh_terms: D062705:Adenovirus Vaccines / Q000276:immunology*; D000818:Animals; D018414:CD8-Positive T-Lymphocytes / Q000821:virology*; D002213:Capsid / Q000737:chemistry; D000939:Epitopes / Q000737:chemistry*; D005622:Friend murine leukemia virus / Q000378:metabolism; D015683:Gene Products, gag / Q000737:chemistry; D007114:Immunization; D051379:Mice; D008957:Models, Genetic; D010455:Peptides / Q000737:chemistry; D012190:Retroviridae / Q000378:metabolism*; D014611:Vaccination; D019444:Vaccines, DNA / Q000737:chemistry; D014765:Viral Vaccines / Q000378:metabolism
chemical_list: D062705:Adenovirus Vaccines; D000939:Epitopes; D015683:Gene Products, gag; D010455:Peptides; D019444:Vaccines, DNA; D014765:Viral Vaccines