title: MMP1-1607(1G>2G) polymorphism and the risk of lung cancer in Lebanon.
abstract: BACKGROUND
  Matrix metalloproteinases (MMPs) are a family of enzymes that degrade various components of the extracellular matrix and are involved in the development and progression of cancer. Lung cancer is the most commonly diagnosed cancer in Lebanon. MMP1 is responsible for degrading stromal collagens, which enhance the ability of neoplastic cells to cross basal membrane of both the endothelium and the vascular endothelium. A recent meta-analysis has suggested that the MMP1-1607 2G allele may be associated with an increased risk for certain types of cancers.
  
  
  OBJECTIVE
  This study was undertaken to investigate the association between guanine insertion polymorphism in the MMP1 promoter and the susceptibility to lung cancer in the Lebanese population.
  
  
  METHODS
  This case-control study was conducted on 41 patients with lung cancer and 51 age-matched healthy controls, recruited from different regions of Lebanon.
  
  
  METHODS
  Cases were histologically confirmed lung cancer patients obtained from different hospitals in Lebanon. Controls were healthy unrelated individuals with no history of cancer or genetic diseases. All subjects were genotyped for MMP1 -1607(1G>2G) polymorphism using polymerase chain reaction-restriction fragment length polymorphism method (PCR-RFLP).
  
  
  RESULTS
  No statistically significant differences were found when genotype and allele distribution of MMP1 -1607(1G>2G) polymorphism were compared between patients with lung cancer and controls [P= 0.6 by chi-squared test on a 3×2 contingency table; allelic P=0.61, OR (95% CI) = 1.18 (0.60-2.31)].
  
  
  CONCLUSIONS
  Our data shows that MMP1 promoter polymorphism is not associated with lung cancer susceptibility in the Lebanese population.
authors.affiliation: Department of Basic Sciences, King Saud bin Abdulaziz University for Health Sciences, Riyadh, KSA.
authors.forename: Hana
authors.initials: H
authors.lastname: Fakhoury
authors.forename: Sara
authors.initials: S
authors.lastname: Noureddine
authors.forename: Hania N
authors.initials: HN
authors.lastname: Chmaisse
authors.forename: Hani
authors.initials: H
authors.lastname: Tamim
authors.forename: Rajaa F
authors.initials: RF
authors.lastname: Makki