title: DT-13 suppresses MDA-MB-435 cell adhesion and invasion by inhibiting             MMP-2/9 via the p38 MAPK pathway.
abstract: Previous research has shown that the Dwarf lilyturf tuber has antitumor             effects. The antitumor ability of DT-13, a saponin monomer isolated from the roots             of the Dwarf lilyturf tuber, is discussed in this study. The results showed that             DT-13 inhibited the proliferation, adhesion and invasion of MDA-MB-435 cells.             DT-13 decreased the excretion and expression of MMP-2/9. Furthermore, DT-13 inhibited             the phosphorylation of p38 in MDA-MB-435 cells. In conclusion, the results suggest             that DT-13 possesses anticancer and antimetastatic properties by inhibiting the             invasion of cancer cells.
authors.affiliation: State Key Laboratory of Natural Medicines, Department of Complex Prescription of TCM, China Pharmaceutical University, Nanjing 210009, PR China.
authors.forename: Yuanyuan
authors.initials: Y
authors.lastname: Zhang
authors.forename: Jihua
authors.initials: J
authors.lastname: Liu
authors.forename: Junping
authors.initials: J
authors.lastname: Kou
authors.forename: Jun
authors.initials: J
authors.lastname: Yu
authors.forename: Boyang
authors.initials: B
authors.lastname: Yu
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000633:toxicity*; D002448:Cell Adhesion / Q000187:drug effects*; D045744:Cell Line, Tumor; D002465:Cell Movement / Q000187:drug effects*; D061307:Human Umbilical Vein Endothelial Cells; D006801:Humans; D031424:Liriope Plant / Q000737:chemistry; D020778:Matrix Metalloproteinase 2 / Q000378:metabolism*; D020780:Matrix Metalloproteinase 9 / Q000378:metabolism*; D010766:Phosphorylation; D018517:Plant Roots / Q000737:chemistry; D012503:Saponins / Q000737:chemistry / Q000633:toxicity*; D015398:Signal Transduction / Q000187:drug effects; D048051:p38 Mitogen-Activated Protein Kinases / Q000378:metabolism*
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D012503:Saponins; C578958:ruscogenin-1-O-(glucopyranosyl-(1-2))(xylopyranosyl-(1-3))fucopyranoside; D048051:p38 Mitogen-Activated Protein Kinases; D020778:Matrix Metalloproteinase 2; D020780:Matrix Metalloproteinase 9