title: Difficult childhood asthma: management and future.
abstract: Diagnosis and management of severe asthma implies the definition of different entities, that is, difficult asthma and refractory severe asthma, but also the different phenotypes included in the term refractory severe asthma. A complete evaluation by a physician expert in asthma is necessary, adapted for each child. Identification of mechanisms involved in different phenotypes in refractory severe asthma may improve the therapeutic approach. The quality of care and monitoring of children with severe asthma is as important as the prescription drug, and is also crucial for differentiating between severe asthma and difficult asthma, whereby expertise is required.
authors.affiliation: Pulmonary Department, University Hospital, Medical University of Lille, Hôpital Calmette, 1 Boulevard Leclercq, Lille Cedex 59037, France. i-tillie@chru-lille.fr
authors.forename: Isabelle
authors.initials: I
authors.lastname: Tillie-Leblond
authors.forename: Antoine
authors.initials: A
authors.lastname: Deschildre
authors.forename: Philippe
authors.initials: P
authors.lastname: Gosset
authors.forename: Jacques
authors.initials: J
authors.lastname: de Blic
mesh_terms: D001249:Asthma / Q000175:diagnosis* / Q000628:therapy*; D002648:Child; D019468:Disease Management; D005544:Forecasting; D006801:Humans; D010641:Phenotype; D016032:Randomized Controlled Trials as Topic; D012720:Severity of Illness Index