title: The in vivo function of mammalian cell and tissue polarity regulators--how to shape and maintain the epidermal barrier.
abstract: The establishment and maintenance of cell and tissue polarity is crucial for a range of biological processes, such as oriented division, migration, adhesion and barrier function. The molecular pathways that regulate cell and tissue polarity have been extensively studied in lower organisms as well as in mammalian cell culture. By contrast, relatively little is still known about how polarization regulates the in vivo formation and homeostasis of mammalian tissues. Several recent papers have identified crucial roles for mammalian polarity proteins in a range of in vivo processes, including stem cell behavior, cell fate determination, junction formation and maintenance and organ development. Using the epidermis of the skin as a model system, this Commentary aims to discuss the in vivo significance of cell and tissue polarity in the regulation of mammalian tissue morphogenesis, homeostasis and disease. Specifically, we discuss the mechanisms by which the molecular players previously identified to determine polarity in vitro and/or in lower organisms regulate epidermal stratification; orient cell division to drive cell fate determination within the epidermal lineage; and orient hair follicles. We also describe how altered polarity signaling contributes to skin cancer.
authors.affiliation: Department of Dermatology, Center for Molecular Medicine, Robert Kochstrasse 21, 50931 Cologne,  Germany.
authors.forename: Michaela T
authors.initials: MT
authors.lastname: Niessen
authors.forename: Sandra
authors.initials: S
authors.lastname: Iden
authors.forename: Carien M
authors.initials: CM
authors.lastname: Niessen
mesh_terms: D000818:Animals; D002454:Cell Differentiation / Q000502:physiology; D016764:Cell Polarity / Q000502:physiology*; D003599:Cytoskeleton / Q000502:physiology*; D000078404:Epidermal Cells; D004817:Epidermis / Q000502:physiology*; D006801:Humans; D015398:Signal Transduction