title: New polyhydroxylated steroid from the South China Sea gorgonian Anthogorgia caerulea.
abstract: One new polyhydroxylated steroid, caerulsteroid A (1), along with nine known analogues (2-10), was isolated from the gorgonian coral Anthogorgia caerulea collected from the South China Sea. The structure of the new compound was elucidated by 1-D and 2-D NMR, and mass spectrometry. The absolute configuration of 1 was assigned on the basis of the absolute configurations of the related congeners 2 and 3, which were determined by application of the modified Mosher's method. The isolated compounds were assayed for their cytotoxicity, antimicrobial activity and lethality towards brine shrimp Artemia salina.
authors.affiliation: Key Laboratory of Marine Drugs, The Ministry of Education of China, School of Medicine and Pharmaceutics, Ocean University of China, Qingdao 266003, PR China.
authors.forename: Ling-Ling
authors.initials: LL
authors.lastname: Sun
authors.forename: Chang-Lun
authors.initials: CL
authors.lastname: Shao
authors.forename: Hui
authors.initials: H
authors.lastname: Hang
authors.forename: Zhi-Yong
authors.initials: ZY
authors.lastname: Guo
authors.forename: Qian
authors.initials: Q
authors.lastname: Xing
authors.forename: Chang-Yun
authors.initials: CY
authors.lastname: Wang
mesh_terms: D000818:Animals; D037421:Anthozoa / Q000737:chemistry* / Q000378:metabolism; D015394:Molecular Structure; D009792:Oceans and Seas; D013256:Steroids / Q000737:chemistry* / Q000378:metabolism
chemical_list: D013256:Steroids; C586011:caerulosteroid A