title: [Preparation of diazepam transdermal gel and its bioavailability].
abstract: OBJECTIVE
  To prepare diazepam transdermal gel and to assess its bioavailability.
  
  
  METHODS
  Using Carbopol 934 as a gel matrix, the diazepam transdermal gel was prepared with glycerol as the humectant and azone as penetration enhancer. The penetration rate of diazepam through excised rabbit skin was measured by Franz diffusion cell and HPLC method. Using diazepam tablets as control, the relative bioavailability of diazepam gel was determined in rabbits.
  
  
  RESULTS
  The transdermal flux of diazepam gel was 39.26 g/cm(2)/h and the bioavailability of diazepam gel was 36.25%.
  
  
  CONCLUSIONS
  Diazepam gel prepared in the study would be developed as a novel transdermal preparation.
authors.affiliation: School of Medicine and Life Sciences, Zhejiang University City College, Hangzhou 310015, China. xuq@zucc.edu.cn
authors.forename: Qing
authors.initials: Q
authors.lastname: Xu
authors.forename: Yao-ping
authors.initials: YP
authors.lastname: Zan
authors.forename: Chu-han
authors.initials: CH
authors.lastname: Gao
mesh_terms: D000279:Administration, Cutaneous; D000818:Animals; D001682:Biological Availability; D003975:Diazepam / Q000008:administration & dosage / Q000493:pharmacokinetics*; D004339:Drug Compounding; D005782:Gels / Q000493:pharmacokinetics; D011817:Rabbits; D012869:Skin Absorption
chemical_list: D005782:Gels; D003975:Diazepam