title: Imaging diagnosis of congenital brain anomalies and injuries.
abstract: Fetal brain is rapidly developing and changing its appearance week by week during pregnancy. The brain is the most important organ but it is quite hard to observe detailed structure of this organ by conventional transabdominal sonography. Transvaginal high-resolution ultrasound and three-dimensional (3D) ultrasound has been a great diagnostic tool for evaluation of three-dimensional structure of fetal central nervous system (CNS). This method has contributed to the prenatal assessment of congenital CNS anomalies, intracranial vascular anomalies and acquired brain damage in utero. It is possible to observe the whole brain structure by magnetic resonance imaging in the post half of pregnancy but transvaginal high-resolution 3D ultrasound is certainly powerful modality as well for understanding brain anatomy. Longitudinally and carefully evaluation of neurological short- or long-term prognosis should be required according to precise prenatal diagnosis, for proper counseling and management based on precise evidence.
authors.affiliation: CRIFM Clinical Research Institute of Fetal Medicine PMC, 7-3-7, Uehommachi, Tennoji, Osaka 543-0001, Japan. evp-pooh@fetal-medicine-pooh.jp
authors.forename: Ritsuko K
authors.initials: RK
authors.lastname: Pooh
mesh_terms: D001921:Brain / Q000002:abnormalities / Q000254:growth & development; D002493:Central Nervous System Diseases / Q000145:classification / Q000151:congenital / Q000175:diagnosis*; D003376:Counseling; D019468:Disease Management; D005260:Female; D005315:Fetal Diseases / Q000145:classification / Q000175:diagnosis* / Q000209:etiology; D006801:Humans; D021621:Imaging, Three-Dimensional / Q000379:methods; D008279:Magnetic Resonance Imaging / Q000379:methods*; D011247:Pregnancy; D011264:Pregnancy Trimesters / Q000502:physiology; D011296:Prenatal Diagnosis / Q000379:methods*; D011379:Prognosis; D016216:Ultrasonography, Prenatal / Q000379:methods*