title: Porohyperviscoelastic model simultaneously predicts parenchymal fluid pressure and reaction force in perfused liver.
abstract: Porohyperviscoelastic (PHVE) modeling gives a simplified continuum approximation of pore fluid behavior within the parenchyma of liver tissue. This modeling approach is particularly applicable to tissue engineering of artificial livers, where the inherent complexity of the engineered scaffolds prevents the use of computational fluid dynamics. The objectives of this study were to simultaneously predict the experimental parenchymal fluid pressure (PFP) and compression response in a PHVE liver model. The model PFP matched the experimental measurements (318 Pa) to within 1.5%. Linear regression of both phases of compression, ramp, and hold, demonstrated a strong correlation between the model and the experimental reaction force (p<0.5). The ability of this PVE model to accurately predict both fluid and solid behavior is important due to the highly vascularized nature of liver tissue and the mechanosensitivity of liver cells to solid matrix and fluid flow properties.
authors.affiliation: Department of Biomedical Engineering, Wake Forest University School of Medicine, Winston-Salem, NC 27157, USA. emoran@wakehealth.edu
authors.forename: Emma C
authors.initials: EC
authors.lastname: Moran
authors.forename: Smitha
authors.initials: S
authors.lastname: Raghunathan
authors.forename: Douglas W
authors.initials: DW
authors.lastname: Evans
authors.forename: Nicholas A
authors.initials: NA
authors.lastname: Vavalle
authors.forename: Tanya
authors.initials: T
authors.lastname: LeRoith
authors.forename: Thomas L
authors.initials: TL
authors.lastname: Smith
authors.forename: Jessica L
authors.initials: JL
authors.lastname: Sparks
mesh_terms: D000818:Animals; D001696:Biomechanical Phenomena; D002417:Cattle; D004548:Elasticity; D005260:Female; D020342:Finite Element Analysis; D057446:Hydrodynamics; D008099:Liver / Q000166:cytology*; D008954:Models, Biological; D010477:Perfusion; D016062:Porosity; D011312:Pressure; D013314:Stress, Mechanical; D013997:Time Factors; D014783:Viscosity