title: Coagulation response in dogs with and without systemic inflammatory response syndrome - preliminary results.
abstract: The impact of systemic inflammatory response syndrome (SIRS) on all phases of coagulation is largely unknown in dogs. Fifty-six healthy dogs (controls) and 25 diseased dogs were included. Based on physical and hematological examination, dogs were classified as "no-SIRS" (n=7) or "SIRS" (n=18). Evaluated coagulation variables included platelets, coagulation times, fibrinogen, antithrombin (AT), FVIII, protein C, protein S, activated protein C (APC)-ratio, calculated from aPTT with and without presence of APC, and kaolin-activated thrombelastography (TEG). Overall, no-SIRS and SIRS were characterized by hypocoaguable state (P<0.001 compared to controls) i.e., prolonged coagulation times, decreased AT (median 59 U/L and 89 U/L versus 126 U/L), and FVIII (median 19 U/L and 70 U/L versus 102 U/L). In no-SIRS and SIRS, APC-ratio was significantly lower than in the controls (median 1.1 and 2.0 versus 2.5, P<0.01, P<0.001). Severe coagulopathies may be present in critically ill dogs without concurrent SIRS. APC-resistance is a frequent finding in severely diseased dogs.
authors.affiliation: Department of Veterinary Clinical Sciences, Clinical Pathology and Clinical Pathophysiology, Germany. Natali.Bauer@vetmed.uni-giessen.de
authors.forename: Natali
authors.initials: N
authors.lastname: Bauer
authors.forename: Andreas
authors.initials: A
authors.lastname: Moritz
mesh_terms: D000818:Animals; D001777:Blood Coagulation; D001780:Blood Coagulation Tests / Q000662:veterinary; D004283:Dog Diseases / Q000097:blood*; D004285:Dogs / Q000097:blood; D005169:Factor VIII / Q000032:analysis; D005260:Female; D005340:Fibrinogen / Q000032:analysis; D008297:Male; D010976:Platelet Count / Q000662:veterinary; D017293:Protein S / Q000032:analysis; D018746:Systemic Inflammatory Response Syndrome / Q000097:blood / Q000662:veterinary*; D013916:Thrombelastography / Q000662:veterinary
chemical_list: D017293:Protein S; D005169:Factor VIII; D005340:Fibrinogen