title: A new cubitane diterpenoid from the soft coral Sinularia crassa.
abstract: A new cubitane diterpenoid, crassalone A (1), was isolated from the marine soft coral Sinularia crassa. The structure was determined by extensive spectroscopic analyses. Compound 1 is not cytotoxic (IC₅₀ > 20 μg/mL) toward the four human cancer cell lines tested (HL60, MDA-MB-231, HCT-116 and DLD-1).
authors.affiliation: Department of Neurosurgery, Chang Gung Memorial Hospital-Kaohsiung Medical Center, Kaohsiung 833, Taiwan.
authors.forename: Ching-Hsiao
authors.initials: CH
authors.lastname: Cheng
authors.forename: Yun-Sheng
authors.initials: YS
authors.lastname: Lin
authors.forename: Zhi-Hong
authors.initials: ZH
authors.lastname: Wen
authors.forename: Jui-Hsin
authors.initials: JH
authors.lastname: Su
mesh_terms: D000230:Adenocarcinoma / Q000188:drug therapy; D000818:Animals; D037421:Anthozoa / Q000737:chemistry*; D001943:Breast Neoplasms / Q000188:drug therapy; D045744:Cell Line, Tumor; D003110:Colonic Neoplasms / Q000188:drug therapy; D015179:Colorectal Neoplasms / Q000188:drug therapy; D004224:Diterpenes / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D015473:Leukemia, Promyelocytic, Acute / Q000188:drug therapy; D015394:Molecular Structure; D009369:Neoplasms / Q000188:drug therapy*
chemical_list: D004224:Diterpenes