title: Subcortical visual shell nuclei targeted by ipRGCs develop from a Sox14+-GABAergic progenitor and require Sox14 to regulate daily activity rhythms.
abstract: Intrinsically photosensitive retinal ganglion cells (ipRGCs) and their nuclear targets in the subcortical visual shell (SVS) are components of the non-image-forming visual system, which regulates important physiological processes, including photoentrainment of the circadian rhythm. While ipRGCs have been the subject of much recent research, less is known about their central targets and how they develop to support specific behavioral functions. We describe Sox14 as a marker to follow the ontogeny of the SVS and find that the complex forms from two narrow stripes of Dlx2-negative GABAergic progenitors in the early diencephalon through sequential waves of tangential migration. We characterize the requirement for Sox14 to orchestrate the correct distribution of neurons among the different nuclei of the network and describe how Sox14 expression is required both to ensure robustness in circadian entrainment and for masking of motor activity.
authors.affiliation: MRC Centre for Developmental Neurobiology, School of Medicine, King's College London, London SE1 1UL, UK.
authors.forename: Alessio
authors.initials: A
authors.lastname: Delogu
authors.forename: Katherine
authors.initials: K
authors.lastname: Sellers
authors.forename: Laskaro
authors.initials: L
authors.lastname: Zagoraiou
authors.forename: Alina
authors.initials: A
authors.lastname: Bocianowska-Zbrog
authors.forename: Shyamali
authors.initials: S
authors.lastname: Mandal
authors.forename: Jordi
authors.initials: J
authors.lastname: Guimera
authors.forename: John L R
authors.initials: JL
authors.lastname: Rubenstein
authors.forename: David
authors.initials: D
authors.lastname: Sugden
authors.forename: Thomas
authors.initials: T
authors.lastname: Jessell
authors.forename: Andrew
authors.initials: A
authors.lastname: Lumsden
mesh_terms: D027182:Amino Acid Transport System y+ / Q000378:metabolism; D000818:Animals; D000831:Animals, Newborn; D051792:Basic Helix-Loop-Helix Proteins / Q000378:metabolism; D001831:Body Temperature / Q000235:genetics; D002465:Cell Movement / Q000235:genetics; D016009:Chi-Square Distribution; D002940:Circadian Rhythm / Q000235:genetics / Q000502:physiology*; D004027:Diencephalon / Q000166:cytology / Q000196:embryology / Q000254:growth & development; D004622:Embryo, Mammalian; D005260:Female; D018507:Gene Expression Regulation, Developmental / Q000235:genetics*; D049452:Green Fluorescent Proteins / Q000235:genetics / Q000378:metabolism; D018398:Homeodomain Proteins; D008297:Male; D051379:Mice; D018345:Mice, Knockout; D009043:Motor Activity / Q000235:genetics; D009154:Mutation / Q000235:genetics; D055495:Neurogenesis / Q000235:genetics; D009924:Organ Culture Techniques; D010775:Photic Stimulation; D012018:Reflex / Q000235:genetics; D012165:Retinal Ganglion Cells / Q000502:physiology*; D055749:SOXB2 Transcription Factors / Q000235:genetics / Q000378:metabolism*; D013234:Stem Cells / Q000502:physiology*; D014157:Transcription Factors / Q000172:deficiency; D014161:Transduction, Genetic / Q000379:methods; D014795:Visual Pathways / Q000166:cytology / Q000502:physiology*; D005680:gamma-Aminobutyric Acid / Q000378:metabolism*
chemical_list: D027182:Amino Acid Transport System y+; D051792:Basic Helix-Loop-Helix Proteins; D049452:Green Fluorescent Proteins; D018398:Homeodomain Proteins; D055749:SOXB2 Transcription Factors; D014157:Transcription Factors; D005680:gamma-Aminobutyric Acid; C088334:Distal-less homeobox proteins; C412624:Slc7a10 protein, mouse; C492175:Sox14 protein, mouse; C485184:enhanced green fluorescent protein