title: Laser-driven beam lines for delivering intensity modulated radiation therapy with particle beams.
abstract: Laser-accelerated particles are a promising option for radiation therapy of cancer by potentially combining a compact, cost-efficient treatment unit with the physical advantages of charged particle beams. To design such a treatment unit we consider different dose delivery schemes and analyze the necessary devices in the required particle beam line for each case. Furthermore, we point out that laser-driven treatment units may be ideal tools for motion adaptation during radiotherapy. Reasons for this are the potential of a flexible gantry and the time structure of the beam with high particle numbers in ultrashort bunches. One challenge that needs to be addressed is the secondary radiation produced in several beam line elements.
authors.affiliation: Department of Radiation Oncology, Technische Universität München, Klinikum rechts der Isar, München, Germany.
authors.forename: Kerstin M
authors.initials: KM
authors.lastname: Hofmann
authors.forename: Stefan
authors.initials: S
authors.lastname: Schell
authors.forename: Jan J
authors.initials: JJ
authors.lastname: Wilkens
mesh_terms: D000054:Acceleration; D006801:Humans; D007834:Lasers; D009068:Movement; D009369:Neoplasms / Q000532:radiotherapy; D061214:Patient Safety; D050397:Radiotherapy, Intensity-Modulated / Q000009:adverse effects / Q000295:instrumentation / Q000379:methods*