title: Metabolic syndrome and psychotropic medications.
abstract: Metabolic syndrome represents a cluster of interrelated metabolic    dysfunctions which are risk factors for the development of diabetes    and cardiovascular disease. Results of clinical studies suggest    significant effects of certain psychotropic medications on weight    gain and manifestation of type II diabetes. The psychoactive drugs    may influence weight gain through increased food consumption    and disruption of satiety signaling system. Some psychoactive medications    cause weight increase, insulin resistance, dyslipidemia,    impairment glucose tolerance/ type II diabetes and hypertension.    Dyslipidemia and increase of insulin resistance can be collateral    or a direct consequence of psychoactive drug actions. The authors    have reviewed accessible literature throughout electronic databases    ten years aback in order to estimate prevalence of metabolic syndrome    in the mentally ill, give an overview of accomplishments in    researching pathophysiology of metabolic syndrome and effects of    psychotropic drugs on apparition and pathophysiological mechanisms    in causing mentioned syndrome. Finally, the authors consolidated    guidelines and references for prevention and treatment of    patients with metabolic syndrome induced by psychotropic drugs.
authors.affiliation: Psychiatric Clinic, Clinical Hospital Centre Osijek, Croatia. filakovic.pavo@kbco.hr
authors.forename: Pavo
authors.initials: P
authors.lastname: Filaković
authors.forename: Anamarija
authors.initials: A
authors.lastname: Petek Erić
authors.forename: Ljiljana
authors.initials: L
authors.lastname: Radanović-Grgurić
mesh_terms: D006801:Humans; D001523:Mental Disorders / Q000188:drug therapy; D024821:Metabolic Syndrome / Q000139:chemically induced*; D011619:Psychotropic Drugs / Q000009:adverse effects*
chemical_list: D011619:Psychotropic Drugs