title: pEl1573 Carrying blaIMP-4, from Sydney, Australia, is closely related to other IncL/M plasmids.
abstract: Complete sequencing of pEl1573, a representative IncL/M plasmid carrying bla(IMP-4) from Sydney, Australia, revealed an ∼60-kb backbone almost identical to those of IncL/M plasmids pCTX-M3, from Poland, and pCTX-M360, from China, and less closely related to pNDM-HK, pOXA-48a, and pEL60, suggesting different lineages. The ∼28-kb Tn2-derived multiresistance region in pEl1573 is inserted in the same location as those in pCTX-M3 and pNDM-HK and shares some of the same components but has undergone rearrangements.
authors.affiliation: Centre for Infectious Diseases and Microbiology, Westmead Hospital, Westmead, New South Wales, Australia. sally.partridge@swahs.health.nsw.gov.au
authors.forename: Sally R
authors.initials: SR
authors.lastname: Partridge
authors.forename: Andrew N
authors.initials: AN
authors.lastname: Ginn
authors.forename: Ian T
authors.initials: IT
authors.lastname: Paulsen
authors.forename: Jonathan R
authors.initials: JR
authors.lastname: Iredell
mesh_terms: D001315:Australia; D002681:China; D003227:Conjugation, Genetic; D004251:DNA Transposable Elements; D004269:DNA, Bacterial; D004755:Enterobacteriaceae / Q000201:enzymology / Q000235:genetics* / Q000472:pathogenicity; D016680:Genome, Bacterial; D006801:Humans; D010802:Phylogeny; D058974:Phylogeography; D010957:Plasmids / Q000145:classification / Q000302:isolation & purification*; D011044:Poland; D018440:beta-Lactam Resistance / Q000235:genetics*; D001618:beta-Lactamases / Q000235:genetics*
chemical_list: D004251:DNA Transposable Elements; D004269:DNA, Bacterial; D001618:beta-Lactamases