title: Bcl-rambo induces apoptosis via interaction with the adenine nucleotide translocator.
abstract: The Bcl-2 family proteins plays a central role in apoptosis. The pro- or anti-apoptotic activities of Bcl-2 family are dependent on the Bcl-2 homology (BH) regions. Bcl-rambo, a new pro-apoptotic member, is unusual in that its pro-apoptotic activity is independent of its BH domains. However, the mechanism underlying Bcl-rambo-induced apoptosis is largely unknown. Mitochondrial localization is indispensable for the pro-apoptotic function of Bcl-rambo. Bcl-rambo interacts physically with the adenine nucleotide translocator (ANT), suppresses the ADT/ATP-dependent translocation activity of ANT. Collectively, our data indicate Bcl-rambo is a pro-apoptotic member of the Bcl-2 family, induces the permeability transition via interaction with ANT.
authors.affiliation: Department of Pathology, School of Medicine, Kyung Hee University, Seoul 130-701, Republic of Korea.
authors.forename: Jee-Youn
authors.initials: JY
authors.lastname: Kim
authors.forename: Kyung-Ja
authors.initials: KJ
authors.lastname: So
authors.forename: Sun
authors.initials: S
authors.lastname: Lee
authors.forename: Jae-Hoon
authors.initials: JH
authors.lastname: Park
mesh_terms: D000244:Adenosine Diphosphate / Q000378:metabolism; D017209:Apoptosis / Q000502:physiology*; D045744:Cell Line, Tumor; D006801:Humans; D053078:Membrane Potential, Mitochondrial; D008928:Mitochondria / Q000378:metabolism; D000226:Mitochondrial ADP, ATP Translocases / Q000378:metabolism*; D033681:Mitochondrial Membrane Transport Proteins / Q000378:metabolism; D000083162:Mitochondrial Permeability Transition Pore; D016297:Mutagenesis, Site-Directed; D054730:Protein Interaction Domains and Motifs; D019253:Proto-Oncogene Proteins c-bcl-2 / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D011994:Recombinant Proteins / Q000737:chemistry / Q000235:genetics / Q000378:metabolism; D015398:Signal Transduction; D014162:Transfection
chemical_list: C431152:BCL2L13 protein, human; D033681:Mitochondrial Membrane Transport Proteins; D000083162:Mitochondrial Permeability Transition Pore; D019253:Proto-Oncogene Proteins c-bcl-2; D011994:Recombinant Proteins; D000244:Adenosine Diphosphate; D000226:Mitochondrial ADP, ATP Translocases