title: The influence of Arhgef1 on pulmonary leukocyte function.
abstract: Resident leukocytes in the lungs of healthy individuals are necessary for the innate and adaptive immune response toward potentially harmful foreign antigens that are inhaled on a constant basis. Under normal circumstances, inflammatory stimuli are effectively eradicated via innate immunity with accompanying resolution of inflammation and repair of the lung tissue. Work in our lab has explored how Arhgef1, an intracellular signaling molecule expressed by hematopoietic cells, participates in immune function with an emphasis on its contribution to pulmonary immunity. This review summarizes our studies on the role of Arhgef1 in regulating pulmonary macrophage function.
authors.affiliation: Integrated Department of Immunology, National Jewish Health and University of Colorado Denver, Denver, CO 80206, USA.
authors.forename: Yue
authors.initials: Y
authors.lastname: Guan
authors.forename: Raul M
authors.initials: RM
authors.lastname: Torres
authors.forename: John M
authors.initials: JM
authors.lastname: Hartney
mesh_terms: D000818:Animals; D020662:Guanine Nucleotide Exchange Factors / Q000737:chemistry / Q000276:immunology*; D006801:Humans; D007962:Leukocytes / Q000276:immunology; D016676:Macrophages, Alveolar / Q000276:immunology*; D017482:Receptors, Thromboxane / Q000276:immunology; D064067:Rho Guanine Nucleotide Exchange Factors
chemical_list: C576600:ARHGEF1 protein, human; D020662:Guanine Nucleotide Exchange Factors; D017482:Receptors, Thromboxane; D064067:Rho Guanine Nucleotide Exchange Factors