title: Pneumocystis jirovecii pneumonia prophylaxis during temozolomide treatment for high-grade gliomas.
abstract: High-grade glioma patients receiving concomitant chemoradiotherapy with temozolomide 75mg/m(2) during six to seven weeks or dose-dense temozolomide regimens especially in combination with chronic use of corticosteroids have a high risk for developing Pneumocystis jirovecii pneumonia. In this review, we define risk groups and propose a guideline for prophylaxis using risk stratification.
authors.affiliation: Department of Medical Oncology, University Medical Center Utrecht, P.O. Box 85500, 3508 GA Utrecht, The Netherlands. f.devos@umcutrecht.nl
authors.forename: Filip Y
authors.initials: FY
authors.lastname: De Vos
authors.forename: Johanna M
authors.initials: JM
authors.lastname: Gijtenbeek
authors.forename: Chantal P
authors.initials: CP
authors.lastname: Bleeker-Rovers
authors.forename: Carla M
authors.initials: CM
authors.lastname: van Herpen
mesh_terms: D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D019072:Antibiotic Prophylaxis; D018906:Antineoplastic Agents, Alkylating / Q000009:adverse effects* / Q000627:therapeutic use; D003606:Dacarbazine / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000627:therapeutic use; D005910:Glioma / Q000150:complications* / Q000188:drug therapy / Q000473:pathology; D006801:Humans; D060787:Neoplasm Grading; D045363:Pneumocystis carinii / Q000276:immunology; D011020:Pneumonia, Pneumocystis / Q000150:complications* / Q000517:prevention & control*; D012307:Risk Factors; D000077204:Temozolomide
chemical_list: D000900:Anti-Bacterial Agents; D018906:Antineoplastic Agents, Alkylating; D003606:Dacarbazine; D000077204:Temozolomide