title: Association of P213S polymorphism of the L-selectin gene with type 2 diabetes and insulin resistance in Chinese population.
abstract: OBJECTIVE
  L-selectin belongs to selectin family of adhesion molecule and participates in the generation and development of type 2 diabetes (T2D). In this study, we evaluated the relationship between the P213S polymorphism of L-selectin gene and T2D and insulin resistance in the Chinese population.
  
  
  METHODS
  We genotyped P213S polymorphism in 801 patients with T2D and 834 healthy controls in the Chinese population using polymerase chain reaction-ligase detection reaction (PCR-LDR) technique. Plasma glucose, insulin, lipid, blood urea nitrogen, creatinine and uric acid levels were measured by biochemical technique.
  
  
  RESULTS
  The frequency of 213PP genotype and P allele of the L-selectin gene in patients with T2D was significantly higher than that in controls (P=0.007; P=0.019, respectively). The relative risk of allele P suffered from T2D was 1.191 times higher than that of allele S. Moreover, the levels of FPG and HOMA-IR of PP and PS genotype carriers were significantly higher than those of SS genotype carriers in the T2D group (P<0.05).
  
  
  CONCLUSIONS
  These findings indicated that the P213S polymorphism of L-selectin gene may contribute to susceptibility to T2D and insulin resistance in the Chinese population, and P allele appears to be a risk factor for T2D.
authors.affiliation: Department of Endocrinology, Gansu Provincial People's Hospital, 204 West Donggang Road, Lanzhou City 730000, Gansu Province, China. liujingwelcome@126.com
authors.forename: Jing
authors.initials: J
authors.lastname: Liu
authors.forename: Ju-xiang
authors.initials: JX
authors.lastname: Liu
authors.forename: San-ni
authors.initials: SN
authors.lastname: Xu
authors.forename: Jin-xing
authors.initials: JX
authors.lastname: Quan
authors.forename: Li-min
authors.initials: LM
authors.lastname: Tian
authors.forename: Qian
authors.initials: Q
authors.lastname: Guo
authors.forename: Jia
authors.initials: J
authors.lastname: Liu
authors.forename: Yun-fang
authors.initials: YF
authors.lastname: Wang
authors.forename: Zhi-yong
authors.initials: ZY
authors.lastname: Shi
mesh_terms: D000483:Alleles; D044466:Asian People / Q000235:genetics*; D016022:Case-Control Studies; D002681:China / Q000453:epidemiology; D003924:Diabetes Mellitus, Type 2 / Q000453:epidemiology / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D007333:Insulin Resistance / Q000235:genetics*; D019041:L-Selectin / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D016133:Polymerase Chain Reaction; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D012307:Risk Factors
chemical_list: D019041:L-Selectin