title: Diabetes and cancer: impact on health-related quality of life.
abstract: OBJECTIVE
  To explore whether three factors (physical function, mental health, and social function) of health-related quality of life (HRQOL) are impacted differently in patients with cancer and diabetes when compared to those with cancer who do not have diabetes at the beginning of chemotherapy.
  
  
  METHODS
  Secondary analysis using baseline data from two randomized, controlled trials.
  
  
  METHODS
  Two comprehensive cancer centers, one community cancer oncology program, and six hospital-affiliated community oncology centers.
  
  
  METHODS
  661 patients aged 21 years or older with a solid tumor cancer or lymphoma undergoing cancer treatment.
  
  
  METHODS
  Baseline data from both randomized, controlled trials were used. The SF-36® was used to measure physical function, mental health, and social function. Analysis included descriptive statistics and a general linear model.
  
  
  METHODS
  Presence or absence of diabetes and physical function, social function, and mental health.
  
  
  RESULTS
  Patients with cancer and diabetes had significantly lower levels of physical function (p < 0.001) when compared to those who had cancer without diabetes. The interaction of diabetes and age was found to be significantly predictive of mental health (p < 0.05).
  
  
  CONCLUSIONS
  The presence of diabetes negatively impacts physical function and mental health in patients undergoing chemotherapy.
  
  
  CONCLUSIONS
  Nurses should be aware of diabetes' effect on HRQOL in patients with cancer. In addition, nurses may need to intervene earlier for patients with diabetes and cancer to maintain or improve their quality of life.
authors.affiliation: College of Nursing, Michigan State University, East Lansing, MI, USA. denise.hershey@hc.msu.edu
authors.forename: Denise Soltow
authors.initials: DS
authors.lastname: Hershey
authors.forename: Barbara
authors.initials: B
authors.lastname: Given
authors.forename: Charles
authors.initials: C
authors.lastname: Given
authors.forename: Alexander
authors.initials: A
authors.lastname: Von Eye
authors.forename: Mei
authors.initials: M
authors.lastname: You
mesh_terms: D000328:Adult; D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D002173:Cancer Care Facilities / Q000706:statistics & numerical data; D015928:Cognitive Behavioral Therapy; D015897:Comorbidity; D003863:Depression / Q000453:epidemiology; D003920:Diabetes Mellitus / Q000453:epidemiology / Q000451:nursing / Q000523:psychology*; D004358:Drug Therapy / Q000523:psychology; D005260:Female; D006801:Humans; D007182:Income; D008297:Male; D017533:Marital Status; D008603:Mental Health; D008875:Middle Aged; D009369:Neoplasms / Q000188:drug therapy / Q000453:epidemiology / Q000451:nursing / Q000523:psychology*; D010809:Physical Fitness; D011788:Quality of Life; D016032:Randomized Controlled Trials as Topic / Q000706:statistics & numerical data; D012919:Social Behavior