title: Caffeic acid phenethyl ester protects kidneys against acetylsalicylic acid toxicity in rats.
abstract: OBJECTIVE
  The aim of this study was to investigate the protective effect of caffeic acid phenethyl ester (CAPE) on acetylsalicylic acid (ASA)-induced renal damage in rats.
  
  
  METHODS
  A total of 40 rats were randomly divided into five groups, with eight rats in each group-group 1: control, not receiving any medication; group 2: ASA (50 mg/kg/day); group 3: ASA (50 mg/kg/day) + CAPE (20 μg/kg/day); group 4: ASA (100 mg/kg/day); and group 5: ASA (100 mg/kg/day) + CAPE (20 μg/kg/day). ASA and CAPE were given via orogastric gavage for 5 days. The total oxidant status (TOS), total antioxidant capacity (TAC), and paraoxonase-1 (PON-1) activity of the blood samples and kidney tissues were determined. Histopathological examinations of the kidneys were performed using light microscopic methods.
  
  
  RESULTS
  The TOS level in the serum of rats and kidney tissues given ASA (groups 2 and 4) significantly increased, but the levels of TAC and PON-1 in these tissues significantly decreased in group 4 when compared with the control rats (p < 0.05). The levels of TAC and PON-1 in the kidney tissues increased and the levels of TOS decreased in the CAPE treatment groups (groups 3 and 5) when compared with the rats in the no CAPE treatment groups (groups 2 and 4). The PON-1, TAC, and TOS values reverted to normal levels in group 5 when compared to group 4 (p < 0.05). These results were supported by histopathological observation.
  
  
  CONCLUSIONS
  Oxidative stress plays an important role in ASA-induced nephrotoxicity, and CAPE may protect against ASA-induced nephrotoxicity in rats.
authors.affiliation: Faculty of Medicine, Department of Urology, Dicle University, Diyarbakir, Turkey. dryasarbozkurt@hotmail.com
authors.forename: Yasar
authors.initials: Y
authors.lastname: Bozkurt
authors.forename: Mehtap
authors.initials: M
authors.lastname: Bozkurt
authors.forename: Gul
authors.initials: G
authors.lastname: Turkçu
authors.forename: Ahmet Ali
authors.initials: AA
authors.lastname: Sancaktutar
authors.forename: Haluk
authors.initials: H
authors.lastname: Soylemez
authors.forename: Necmettin
authors.initials: N
authors.lastname: Penbegul
authors.forename: Murat
authors.initials: M
authors.lastname: Atar
authors.forename: Mehmet Nuri
authors.initials: MN
authors.lastname: Bodakcı
authors.forename: Namık Kemal
authors.initials: NK
authors.lastname: Hatipoglu
authors.forename: Hatice
authors.initials: H
authors.lastname: Yuksel
authors.forename: Erkan
authors.initials: E
authors.lastname: Kıbrıslı
authors.forename: Celal
authors.initials: C
authors.lastname: Yavuz
mesh_terms: D058186:Acute Kidney Injury / Q000139:chemically induced / Q000378:metabolism / Q000517:prevention & control*; D000818:Animals; D001241:Aspirin / Q000633:toxicity*; D002109:Caffeic Acids / Q000008:administration & dosage* / Q000493:pharmacokinetics; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D005260:Female; D007668:Kidney / Q000187:drug effects / Q000378:metabolism / Q000473:pathology*; D016328:NF-kappa B / Q000037:antagonists & inhibitors; D018384:Oxidative Stress / Q000187:drug effects; D010626:Phenylethyl Alcohol / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000493:pharmacokinetics; D051381:Rats; D017208:Rats, Wistar
chemical_list: D002109:Caffeic Acids; D016328:NF-kappa B; C055494:caffeic acid phenethyl ester; D010626:Phenylethyl Alcohol; D001241:Aspirin