title: Enantioselective zinc-mediated conjugate addition of terminal alkynes to enones.
abstract: Zinc for conjugate alkynylation: The enantioselective conjugate addition of terminal alkynes to 2-arylidene-1,3-diketones in the presence of diethylzinc and a catalytic amount of (R)-VANOL has been developed. The reaction can be applied to different aromatic and heteroaromatic alkynes and enones, giving the expected products in good yield and with enantiomeric excesses up to 91%. The products can be enantiomerically enriched up to 99% ee by crystallization (see scheme).
authors.affiliation: Departament de Química Orgànica, Facultat de Química, Universitat de València, C/Dr. Moliner 50, E-46100 Burjassot (València), Spain. gonzalo.blay@uv.es
authors.forename: Gonzalo
authors.initials: G
authors.lastname: Blay
authors.forename: Luz
authors.initials: L
authors.lastname: Cardona
authors.forename: José R
authors.initials: JR
authors.lastname: Pedro
authors.forename: Amparo
authors.initials: A
authors.lastname: Sanz-Marco