title: Synthesis and biological evaluation of a new vitamin D2 analogue.
abstract: A new vitamin D(2) analogue was synthesized using the Julia-Kocienski olefination. It has antiproliferative effects on cell lines from squamous cell carcinomas of colon and head and neck, but is also as hypercalcaemic as calcitriol in vivo.
authors.affiliation: Departamento de Química Orgánica, Facultad de Química, Universidad de Vigo, 36200 Vigo, Spain.
authors.forename: Zoila
authors.initials: Z
authors.lastname: Gándara
authors.forename: Manuel
authors.initials: M
authors.lastname: Pérez
authors.forename: Débora G
authors.initials: DG
authors.lastname: Salomón
authors.forename: María J
authors.initials: MJ
authors.lastname: Ferronato
authors.forename: María E
authors.initials: ME
authors.lastname: Fermento
authors.forename: Alejandro C
authors.initials: AC
authors.lastname: Curino
authors.forename: María M
authors.initials: MM
authors.lastname: Facchinetti
authors.forename: Generosa
authors.initials: G
authors.lastname: Gómez
authors.forename: Yagamare
authors.initials: Y
authors.lastname: Fall
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D002118:Calcium / Q000097:blood; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D004354:Drug Screening Assays, Antitumor; D004872:Ergocalciferols / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D045325:HCT116 Cells; D006801:Humans; D051379:Mice; D015394:Molecular Structure; D013329:Structure-Activity Relationship
chemical_list: D000970:Antineoplastic Agents; D004872:Ergocalciferols; D002118:Calcium