title: D-Pinitol attenuates 7, 12 dimethylbenz [a] anthracene induced hazards through modulating protein bound carbohydrates, adenosine triphosphatases and lysosomal enzymes during experimental mammary carcinogenesis.
abstract: We have reported here that the ameliorative potentials of D-Pinitol during 7, 12-Dimethylbenz [a] anthracene induced experimental breast carcinogenesis. DMBA is a potent organ specific carcinogen which is widely employed to induce mammary carcinoma in rats. D-Pinitol a natural inositol has been reported to found in soybean with many biological functions. The female sprague dawley rats were subjected to carcinogen 7, 12-DMBA and the ameliorative potentials of dietary compound D-Pinitol was investigated with reference to cell surface glycoproteins, lysosomal enzymes and adenosine triphosphatases. Interestingly, administration of D-Pinitol was found to be significantly down regulated the breast tissue glycoproteins and lysosomal enzymes and in contrast the levels of adenosine triphosphatases were remarkably up regulated. Further, the biochemical changes were well reflected and evidenced in the histology of breast and liver tissues. Thus, it can be concluded from the present study that D-Pinitol efficiently attenuates the hazardous consequences of the environmental carcinogen 7,12-DMBA through modulating cell surface glycoproteins, membrane protective role both in lysosomal and ATPase compartment via its antioxidant nature which ultimately results in the findings of future innovative remedies for genotoxin mediated hazards.
authors.affiliation: Department of Pharmacology and Environmental Toxicology, Dr. A. L. Mudhaliar Post Graduate Institute of Basic Medical Sciences, University of Madras, Taramani Campus, Chennai- 600 113, Tamilnadu, India.
authors.forename: Thamaraiselvan
authors.initials: T
authors.lastname: Rengarajan
authors.forename: Natarajan
authors.initials: N
authors.lastname: Nandakumar
authors.forename: Maruthaiveeran Periyasamy
authors.initials: MP
authors.lastname: Balasubramanian
mesh_terms: D015127:9,10-Dimethyl-1,2-benzanthracene / Q000008:administration & dosage*; D000251:Adenosine Triphosphatases / Q000378:metabolism; D000818:Animals; D001940:Breast / Q000187:drug effects / Q000473:pathology; D002274:Carcinogens, Environmental / Q000008:administration & dosage*; D005260:Female; D007294:Inositol / Q000008:administration & dosage / Q000031:analogs & derivatives*; D008099:Liver / Q000187:drug effects / Q000473:pathology; D008247:Lysosomes / Q000201:enzymology; D008325:Mammary Neoplasms, Experimental / Q000139:chemically induced / Q000188:drug therapy / Q000378:metabolism; D008562:Membrane Glycoproteins / Q000378:metabolism; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D002274:Carcinogens, Environmental; D008562:Membrane Glycoproteins; C021730:pinitol; D007294:Inositol; D015127:9,10-Dimethyl-1,2-benzanthracene; D000251:Adenosine Triphosphatases