title: Peptide-guided surface-enhanced Raman scattering probes for localized cell composition analysis.
abstract: The ability to control the localization of surface-enhanced Raman scattering (SERS) nanoparticle probes in bacterial cells is critical to the development of analytical techniques that can nondestructively determine cell composition and phenotype. Here, selective localization of SERS probes was achieved at the outer bacterial membrane by using silver nanoparticles functionalized with synthetic hydrophobic peptides.
authors.affiliation: Department of Biological Systems Engineering, Virginia Tech, Blacksburg, Virginia, USA.
authors.forename: Ahmad I M
authors.initials: AI
authors.lastname: Athamneh
authors.forename: Ryan S
authors.initials: RS
authors.lastname: Senger
mesh_terms: D001419:Bacteria; D001425:Bacterial Outer Membrane Proteins / Q000032:analysis*; D022082:Cellular Structures; D053768:Metal Nanoparticles / Q000737:chemistry; D010455:Peptides; D010641:Phenotype; D012834:Silver / Q000737:chemistry; D013059:Spectrum Analysis, Raman / Q000379:methods*; D013499:Surface Properties
chemical_list: D001425:Bacterial Outer Membrane Proteins; D010455:Peptides; D012834:Silver