title: [Clinical characteristics of the patients with occupational chronic carbon disulfide poisoning in a chemical fiber factory of Nanjing].
abstract: OBJECTIVE
  To analyze the clinical characteristics of 267 cases with occupational chronic carbon disulfide (CS(2)) poisoning and to provide the basis for revising the items of periodical medical examination of workers occupationally exposed to CS(2).
  
  
  METHODS
  The subjects of present study were 267 patients with mild CS(2) poisoning diagnosed according to "Diagnostic Criteria of Occupational Chronic Carbon Disulfide Poisoning (GBZ4-2002)" from April in 2006 to May in 2010. All patients were from the same chemical fiber factory. When a subject was diagnosed as patient with CS(2) poisoning, who should interview with questionnaire which included the illness and occupational history, symptoms, individual habits. The physical examination, nervous test, cardiovascular test, biochemical test and electromyogram were performed.
  
  
  RESULTS
  The rate of decreased motor conduction velocity was 87.3% (233/267 roots). The highest detection rate of slowing conduction velocity was the common peroneal motor nerve which was 48.6% (138/248 roots) and the second was median motor nerve with delay rate of 37% (155/419 roots). The main symptoms of the patients were neurasthenia, numbness and paresthesia. The rates of abnormal achilles tendon reflex and knee jerk reflex in patients were were 79.4% and 49.8%, respectively. The detected rates of patients with ST-segment changes and hypertension were 19.1% and 27.5%, respectively. The rates of hypertension, systolic pressure and diastolic pressure were 27.3%, 22.5% and 21.1%, respectively. The rates of lactate dehydrogenase (LDH), triglycerides (TG) and low density lipoprotein (LDL) were high. The detected rates of urine acid, indirect bilirubin and total bilirubin in male patients were higher than those in female patients. In addition, the abnormal detected rate of urea nitrogen and indirect bilirubin increased with exposure years.
  
  
  CONCLUSIONS
  Occupational chronic CS(2) poisoning mainly affects the nervous system, as well as liver and kidney function. Detecting the median and common peroneal motor nerve conduction velocities could be the screening indicators for the peripheral nerve injury induced by CS(2) in the occupational exposure population during the periodical occupational medical examinations.
authors.affiliation: Occupational Disease Prevention Hospital in Nanjing, Nanjing 210029, China.
authors.forename: Chun-ping
authors.initials: CP
authors.lastname: Ji
authors.forename: Hai-yan
authors.initials: HY
authors.lastname: Song
authors.forename: Jin
authors.initials: J
authors.lastname: Xu
authors.forename: Mei-lin
authors.initials: ML
authors.lastname: Wang
authors.forename: Zhi-guo
authors.initials: ZG
authors.lastname: Hou
authors.forename: Chun-long
authors.initials: CL
authors.lastname: Wei
authors.forename: Qiu
authors.initials: Q
authors.lastname: Dong
authors.forename: Shou-yu
authors.initials: SY
authors.lastname: Wang
authors.forename: Shan-lei
authors.initials: SL
authors.lastname: Qiao
authors.forename: Bao-li
authors.initials: BL
authors.lastname: Zhu
authors.forename: Chun-hui
authors.initials: CH
authors.lastname: Ni
mesh_terms: D000328:Adult; D000368:Aged; D002246:Carbon Disulfide / Q000506:poisoning*; D002617:Chemical Industry; D005260:Female; D006801:Humans; D007668:Kidney / Q000187:drug effects / Q000503:physiopathology; D008099:Liver / Q000187:drug effects / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D009098:Multiphasic Screening; D009420:Nervous System / Q000187:drug effects / Q000503:physiopathology; D009431:Neural Conduction; D016273:Occupational Exposure
chemical_list: D002246:Carbon Disulfide