title: Quantum dot applications endowing novelty to analytical proteomics.
abstract: This review surveys all the state-of-art applications of quantum dots (QDs) in conventional and modern analytical methods in proteomic studies. A brief introduction of QDs and their properties is initially presented followed by outlining the application of QDs in fluorescence, MS, imaging, and cancer-based proteomics. The in-depth application of QDs in MALDI-MS and surface assisted laser desorption/ionization-MS has been elaborately discussed, summarizing the speculated mechanism behind the protein-QDs interactions during QD matrix applications leading to enhanced detection sensitivity.
authors.affiliation: Department of Chemistry, National Sun Yat Sen University, Kaohsiung, Taiwan. hwu@faculty.nsysu.edu.tw
authors.forename: Hui-Fen
authors.initials: HF
authors.lastname: Wu
authors.forename: Judy
authors.initials: J
authors.lastname: Gopal
authors.forename: Hani Nasser
authors.initials: HN
authors.lastname: Abdelhamid
authors.forename: Nazim
authors.initials: N
authors.lastname: Hasan
mesh_terms: D006801:Humans; D057054:Molecular Imaging / Q000379:methods; D036103:Nanotechnology / Q000379:methods; D040901:Proteomics / Q000379:methods*; D045663:Quantum Dots; D019032:Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization / Q000379:methods