title: [Management of biofilm-associated infections: what can we expect from recent research on biofilm lifestyles?].
abstract: Biofilms are surface-associated microbial communities present in all environments. Although biofilms play important ecological roles, they also lead to negative or deleterious effects in industrial and medical settings. In the latter, high levels of antibiotic tolerance of bacterial biofilms developing on medical devices and during chronic infections determine the physiopathology of many healthcare-associated infections. Original approaches have been developed to avoid bacterial adhesion or biofilm development targetting specific mechanisms or pathways. We herein review recent data about biofilm lifestyle understanding and ways to fight against related infections.
authors.affiliation: Institut Pasteur, Unité de Génétique des Biofilms, Département de Microbiologie, 75015 Paris, France.
authors.forename: David
authors.initials: D
authors.lastname: Lebeaux
authors.forename: Jean-Marc
authors.initials: JM
authors.lastname: Ghigo
mesh_terms: D000890:Anti-Infective Agents / Q000493:pharmacokinetics / Q000627:therapeutic use; D001424:Bacterial Infections / Q000188:drug therapy* / Q000382:microbiology / Q000517:prevention & control; D018441:Biofilms / Q000187:drug effects / Q000254:growth & development; D055499:Catheter-Related Infections / Q000188:drug therapy / Q000382:microbiology / Q000517:prevention & control; D002448:Cell Adhesion; D020099:Coated Materials, Biocompatible; D003550:Cystic Fibrosis / Q000150:complications / Q000382:microbiology; D003731:Dental Caries / Q000188:drug therapy / Q000382:microbiology / Q000628:therapy; D004352:Drug Resistance, Microbial; D004696:Endocarditis / Q000188:drug therapy / Q000382:microbiology; D006801:Humans; D006920:Hygiene; D059013:Microbial Consortia; D009181:Mycoses / Q000188:drug therapy* / Q000382:microbiology / Q000517:prevention & control; D016459:Prosthesis-Related Infections / Q000188:drug therapy / Q000382:microbiology / Q000517:prevention & control; D053038:Quorum Sensing; D013499:Surface Properties; D014552:Urinary Tract Infections / Q000188:drug therapy / Q000382:microbiology; D014612:Vaccines; D014946:Wound Infection / Q000188:drug therapy / Q000382:microbiology
chemical_list: D000890:Anti-Infective Agents; D020099:Coated Materials, Biocompatible; D014612:Vaccines