title: ER stress in diffuse large B cell lymphoma: GRP94 is a possible biomarker in germinal center versus activated B-cell type.
abstract: The process of B-cell development is characterized by the activation of the unfolded protein response. Under certain circumstances, the unfolded protein response can be manipulated in a cell death-inducing way. Therefore, tackling the unfolded protein response might be an attractive strategy in the treatment of diffuse large B-cell lymphomas. Our research showed more basal unfolded protein response activity and differences in the inducibility of ER stress in activated B-cell versus germinal center cell lines. Moreover, the diffuse large B cell lymphoma patient data revealed that the glucose-regulated protein 94 is new potential discriminator for diffuse large B cell lymphoma.
authors.affiliation: Department of Hematology, Ghent University Hospital, Ghent, Belgium. Jerina.Boelens@ugent.be
authors.forename: Jerina
authors.initials: J
authors.lastname: Boelens
authors.forename: Jean-Philippe
authors.initials: JP
authors.lastname: Jais
authors.forename: Barbara
authors.initials: B
authors.lastname: Vanhoecke
authors.forename: Ilse
authors.initials: I
authors.lastname: Beck
authors.forename: Heleen
authors.initials: H
authors.lastname: Van Melckebeke
authors.forename: Jan
authors.initials: J
authors.lastname: Philippé
authors.forename: Marc
authors.initials: M
authors.lastname: Bracke
authors.forename: Fabrice
authors.initials: F
authors.lastname: Jardin
authors.forename: Josette
authors.initials: J
authors.lastname: Brière
authors.forename: Karen
authors.initials: K
authors.lastname: Leroy
authors.forename: Fritz
authors.initials: F
authors.lastname: Offner
authors.forename: Sofie
authors.initials: S
authors.lastname: Lust
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage; D017209:Apoptosis; D014408:Biomarkers, Tumor / Q000378:metabolism; D045744:Cell Line, Tumor; D003520:Cyclophosphamide / Q000008:administration & dosage; D004317:Doxorubicin / Q000008:administration & dosage; D059865:Endoplasmic Reticulum Stress; D006801:Humans; D016403:Lymphoma, Large B-Cell, Diffuse / Q000188:drug therapy / Q000378:metabolism* / Q000473:pathology*; D008562:Membrane Glycoproteins / Q000032:analysis / Q000502:physiology*; D011241:Prednisone / Q000008:administration & dosage; D056811:Unfolded Protein Response; D014750:Vincristine / Q000008:administration & dosage
chemical_list: D014408:Biomarkers, Tumor; D008562:Membrane Glycoproteins; C053387:endoplasmin; D014750:Vincristine; D004317:Doxorubicin; D003520:Cyclophosphamide; D011241:Prednisone