title: Key role of the positive feedback between PGE(2) and COX2 in the biology of myeloid-derived suppressor cells.
abstract: PGE(2) is the key factor needed for MDSCs development, accumulation and functional stability. PGE(2) initiates an EP2/EP4-mediated positive feedback between COX2 and PGE(2) in monocytic precursors, redirecting dendritic cell differentiation to MDSCs. COX2- or EP2/EP4- blockade abrogates MDSC functions and their CXCR4-CXCL12-mediated attraction to cancer environment, providing convenient immunotherapeutic targets.
authors.affiliation: Department of Surgery; University of Pittsburgh; Pittsburgh, PA USA.
authors.forename: Nataŝa
authors.initials: N
authors.lastname: Obermajer
authors.forename: Pawel
authors.initials: P
authors.lastname: Kalinski