title: Acute pseudo-septic arthritis following viscosuplementation of the knee.
abstract: A 70-year-old woman with a history of medial femoro-tibial compartment of knee osteoarthritis was admitted for acute arthritis six days after a second intra-articular injection of Hyaluronic acid. The joint fluid was inflammatory, with no crystals, and laboratory tests showed marked inflammation leading to antibiotic treatment for suspected septic arthritis. The persistent symptoms and negative results of joint fluid and blood cultures led to discontinuation of the antibiotic therapy after 10 days. Anti-inflammatory with rehabilitation therapy of the knee relieved the symptoms, and the patient was discharged home 3 weeks after her admission. Aseptic arthritis induced by repeated Hyaluronic acid injection is the most likely diagnosis. Physicians should be conscious of this extremely severe complication.
authors.affiliation: Rheumatology Department, El Ayachi Hospital, Mohammed the Vth University, Rabat, Morocco.
authors.forename: Zineb
authors.initials: Z
authors.lastname: Idrissi
authors.forename: Karima
authors.initials: K
authors.lastname: Benbouazza
authors.forename: Maryam
authors.initials: M
authors.lastname: Fourtassi
authors.forename: Hanae
authors.initials: H
authors.lastname: Raissouni
authors.forename: Meriem
authors.initials: M
authors.lastname: El Aadmi
authors.forename: Fatima
authors.initials: F
authors.lastname: Zanat
authors.forename: Najia
authors.initials: N
authors.lastname: Hajjaj-Hassouni
mesh_terms: D000208:Acute Disease; D000368:Aged; D001170:Arthritis, Infectious / Q000139:chemically induced*; D005260:Female; D006801:Humans; D006820:Hyaluronic Acid / Q000009:adverse effects*; D007719:Knee Joint; D055676:Viscosupplementation / Q000009:adverse effects*; D055675:Viscosupplements / Q000009:adverse effects*
chemical_list: D055675:Viscosupplements; D006820:Hyaluronic Acid