title: Ru(CO)-salen-catalyzed synthesis of enantiopure aziridinyl ketones and formal asymmetric synthesis of (+)-PD 128907.
abstract: Aziridination of vinyl ketones using SESN(3) in the presence Ru(CO)-salen complex 1 provides the enantiopure aziridinyl ketones that can serve as useful chiral building blocks. A formal asymmetric synthesis of (+)-PD 128907 was achieved in an eight-step sequence via aziridination.
authors.affiliation: Department of Chemistry, Faculty of Science, Graduate School, Kyushu University, Hakozaki, Fukuoka 812-8581, Japan.
authors.forename: Yasuaki
authors.initials: Y
authors.lastname: Fukunaga
authors.forename: Tatsuya
authors.initials: T
authors.lastname: Uchida
authors.forename: Yutaro
authors.initials: Y
authors.lastname: Ito
authors.forename: Kenji
authors.initials: K
authors.lastname: Matsumoto
authors.forename: Tsutomu
authors.initials: T
authors.lastname: Katsuki
mesh_terms: D001388:Aziridines / Q000138:chemical synthesis* / Q000737:chemistry; D001578:Benzopyrans / Q000138:chemical synthesis* / Q000737:chemistry; D007659:Ketones / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D009942:Organometallic Compounds / Q000737:chemistry*; D010078:Oxazines / Q000138:chemical synthesis* / Q000737:chemistry; D012428:Ruthenium / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D001388:Aziridines; D001578:Benzopyrans; D007659:Ketones; D009942:Organometallic Compounds; D010078:Oxazines; C062458:3,4,4a,10b-tetrahydro-4-propyl-2H,5H-(1)benzopyrano(4,3-b)-1,4-oxazin-9-ol; D012428:Ruthenium