title: Review: Structure-function and biological properties of the atypical chemokine receptor D6.
abstract: The atypical chemokine receptor D6 was initially called "silent" on the basis of lack of conventional signaling events that lead to directional cell migration. It has emerged that D6 is able to bind and drive to degradative compartments most inflammatory CC chemokines and that is able to convey G-protein independent signaling events to optimize its scavenging activity. We here summarize the knowledge available today on D6 structural and signaling properties and its essential role for the control of inflammatory cells traffic and proper development of the adaptive immune response.
authors.affiliation: Department of Medical Biotechnologies and Translational Medicine, University of Milan, Rozzano (MI), Italy.
authors.forename: Cinzia
authors.initials: C
authors.lastname: Cancellieri
authors.forename: Nicoletta
authors.initials: N
authors.lastname: Caronni
authors.forename: Alessandro
authors.initials: A
authors.lastname: Vacchini
authors.forename: Benedetta
authors.initials: B
authors.lastname: Savino
authors.forename: Elena M
authors.initials: EM
authors.lastname: Borroni
authors.forename: Massimo
authors.initials: M
authors.lastname: Locati
authors.forename: Raffaella
authors.initials: R
authors.lastname: Bonecchi
mesh_terms: D056704:Adaptive Immunity / Q000235:genetics / Q000276:immunology; D000818:Animals; D002465:Cell Movement / Q000235:genetics / Q000276:immunology; D006801:Humans; D008954:Models, Biological; D021381:Protein Transport; D054447:Receptors, CCR10 / Q000737:chemistry* / Q000235:genetics / Q000378:metabolism / Q000502:physiology*; D015398:Signal Transduction / Q000235:genetics / Q000276:immunology; D013329:Structure-Activity Relationship; D000097628:Chemokine Receptor D6
chemical_list: D054447:Receptors, CCR10; D000097628:Chemokine Receptor D6