title: [Determination of methyl isocyanate (MIC) in air of workplaces by HPLC].
abstract: OBJECTIVE
  To establish the method of detecting the concentrations of methyl isocyanate (MIC) in air of workplaces with high performance liquid chromatographic (HPLC).
  
  
  METHODS
  Samples are collected by XAD-7 tubes coated with 1-(2-pyridyl) piperazine (1-2PP). Samples are desorbed with acetonitrile (ACN) and analyzed by high performance liquid chromatography (HPLC) using a fluorescence detector.
  
  
  RESULTS
  There was a linear relationship within the range of 0.01 ∼ 10 µg/ml, and the detection limit was 5.3×10(-4) µg/ml. The minimum detectable concentration was 0.01 µg/ml, and the lowest detected concentration was 3.3×10(-3) mg/m(3). The relative standard deviation was 2.2% ∼ 5.3%. The average desorption efficiency was 90% and the sampling efficiencies were 100%. The samples could be stored for 10 days in cold storage condition.
  
  
  CONCLUSIONS
  The present method could meet with the requirements of Guide for establishing occupational health standards-Part4 Determination methods of air chemicals in workplace and be feasible for determination of MIC in workplace air.
authors.affiliation: Shandong Academy of Occupational Health and Occupational Medicine, Jinan, Shandong 250062, China.
authors.forename: Li-qun
authors.initials: LQ
authors.lastname: Song
authors.forename: Yang
authors.initials: Y
authors.lastname: Yu
authors.forename: Xiao-yun
authors.initials: XY
authors.lastname: Wang
mesh_terms: D000395:Air Pollutants, Occupational / Q000032:analysis*; D002851:Chromatography, High Pressure Liquid / Q000379:methods*; D004784:Environmental Monitoring / Q000379:methods*; D017953:Isocyanates / Q000032:analysis*; D017132:Workplace
chemical_list: D000395:Air Pollutants, Occupational; D017953:Isocyanates; C008461:methyl isocyanate