title: Effects of intermittent normobaric hypoxia on the state of the CNS and cerebral circulation in children with cerebral palsy.
abstract: We studied the effects of intermittent normobaric hypoxia (INH) on the processes of CNS functions and cerebral circulation recovery in children with cerebral palsy (CP). Altogether, 87 patients (from 8.5 months to 12 years) with CP were examined and received the course of treatment. Clinico-neurophysiological examination was performed before the treatment and immediately after termination of the therapeutic course. Patients were divided into two groups; age and sex distributions and clinical manifestations of CP were randomized. The comparison group was formed from 34 children who received the course of the generally accepted complex therapy (medicamental treatment, massage, Bobat-therapy, Vojta-therapy at al).. The main group included 53 patients who, in addition to the same therapy, were exposed to INH using an individual apparatus for artificial mountain air, Borey-M, made in the Scientific Medico-Engineering Center NORT (Ukrainian National Academy of Sciences, Kyiv). Children of the main group were exposed to the dosed normobaric sanogenetic level hypoxia intermittently once per day. For this purpose, we used a normobaric gas hypoxic mixture (12% O2 + 88% N2). Each cycle included a 15-min-long episode of breathing with the gas mixture alternated by a 5-min-long episode of breathing an ambient atmospheric air. The number of hypoxic cycles was gradually increased (from one to three). The entire course of treatment included, on average, 10 sessions. After complex therapy the stable positive effects on the motor status were observed in 94% of patients of the main group (exposed to INH) and in 74% of patients of the comparison group (unexposed to INH). EEG examination showed that positive dynamics of spectral EEG components were in 70% of patients of the main group and in 56% of children of the comparison group. Doppler examination showed that brain hemodynamics was normalized in 85% of patients of the main group and in 59% of children of the comparison group. In the course of ophthalmoscopic examination, we found that the dynamics of indices of the state of the eye fundus were expressed more clearly in children of the main group than in patients of the comparison group (in 32 and 12% of patients, respectively).
authors.affiliation: OO Bogomoletz Institute of Physiology, National Academy of Sciences of Ukraine, Kyiv.
authors.forename: K V
authors.initials: KV
authors.lastname: Yatsenko
authors.forename: V A
authors.initials: VA
authors.lastname: Berezovskii
authors.forename: J V
authors.initials: JV
authors.lastname: Deyeva
mesh_terms: D002490:Central Nervous System / Q000000981:diagnostic imaging / Q000187:drug effects* / Q000503:physiopathology; D002547:Cerebral Palsy / Q000000981:diagnostic imaging / Q000503:physiopathology / Q000628:therapy*; D002560:Cerebrovascular Circulation / Q000187:drug effects*; D002648:Child; D002675:Child, Preschool; D004569:Electroencephalography; D005260:Female; D006801:Humans; D000860:Hypoxia; D007223:Infant; D008297:Male; D009887:Ophthalmoscopy; D010100:Oxygen / Q000627:therapeutic use*; D011597:Psychomotor Performance / Q000187:drug effects; D012119:Respiration; D017585:Ultrasonography, Doppler, Transcranial
chemical_list: D010100:Oxygen