title: [Diabetes mellitus and osteoporosis. Bone quality in diabetes].
abstract: Diabetes deteriorate bone material properties. Not only hyperglycemia, but also oxidative stress induce the reduction in enzymatic beneficial cross-links and the accumulation of disadvantageous non-enzymatic cross-linking advanced glycation end products (AGEs) such as pentosidine in bone. In this review, I describe the mechanism of low bone quality in diabetes.
authors.affiliation: Department of Orthopaedic Surgery, Jikei University School of Medicine, Tokyo, Japan.
authors.forename: Mitsuru
authors.initials: M
authors.lastname: Saito
mesh_terms: D001842:Bone and Bones / Q000378:metabolism* / Q000473:pathology; D048909:Diabetes Complications / Q000378:metabolism* / Q000503:physiopathology; D017127:Glycation End Products, Advanced / Q000378:metabolism*; D006801:Humans; D006943:Hyperglycemia / Q000378:metabolism; D010024:Osteoporosis / Q000378:metabolism; D018384:Oxidative Stress / Q000502:physiology
chemical_list: D017127:Glycation End Products, Advanced