title: Multifaceted applications of nanomaterials in cell engineering and therapy.
abstract: Nanomaterials with superior physiochemical properties have been rapidly developed and integrated in every aspect of cell engineering and therapy for translating their great promise to clinical success. Here we demonstrate the multifaceted roles played by innovatively-designed nanomaterials in addressing key challenges in cell engineering and therapy such as cell isolation from heterogeneous cell population, cell instruction in vitro to enable desired functionalities, and targeted cell delivery to therapeutic sites for prompting tissue repair. The emerging trends in this interdisciplinary and dynamic field are also highlighted, where the nanomaterial-engineered cells constitute the basis for establishing in vitro disease model; and nanomaterial-based in situ cell engineering are accomplished directly within the native tissue in vivo. We will witness the increasing importance of nanomaterials in revolutionizing the concept and toolset of cell engineering and therapy which will enrich our scientific understanding of diseases and ultimately fulfill the therapeutic demand in clinical medicine.
authors.affiliation: Department of Biomedical Engineering, School of Medicine, Tsinghua University, Beijing 100084, China.
authors.forename: Hui
authors.initials: H
authors.lastname: Chen
authors.forename: Yang
authors.initials: Y
authors.lastname: Zeng
authors.forename: Wei
authors.initials: W
authors.lastname: Liu
authors.forename: Shan
authors.initials: S
authors.lastname: Zhao
authors.forename: Jinhui
authors.initials: J
authors.lastname: Wu
authors.forename: Yanan
authors.initials: Y
authors.lastname: Du
mesh_terms: D000818:Animals; D060846:Cell Engineering / Q000379:methods*; D053595:Embryonic Stem Cells / Q000166:cytology; D006801:Humans; D049329:Nanostructures / Q000008:administration & dosage* / Q000737:chemistry*; D044968:Regenerative Medicine / Q000379:methods; D033581:Stem Cell Transplantation / Q000379:methods*