title: Sleep and cardiometabolic function in obese adolescent girls with polycystic ovary syndrome.
abstract: OBJECTIVE
  To compare the polysomnography findings and cardiometabolic function among adolescent girls with polycystic ovary syndrome (PCOS) and matched female and male controls.
  
  
  METHODS
  Retrospective chart review of electronic medical records of 28 girls with PCOS (age: 16.8±1.9 years, body mass index (BMI) Z-score 2.4±0.4), 28 control females (age: 17.1±1.8, BMI Z-score 2.4±0.3) and 28 control males (age: 16.6±1.6, BMI Z-score 2.5±0.5) in a tertiary care centre.
  
  
  RESULTS
  The prevalence of obstructive sleep apnoea (OSA) was higher in girls with PCOS compared to control females (16/28 (57%) vs. 4/28(14.3%), p<0.01); however, it was comparable to that of the control males (16/28(57%) vs. 21/28(75%), p=0.4). Girls with PCOS had a significantly higher prevalence of insulin resistance compared to control females and control males (20/28 (71.4%) vs. 9/22 (41.0%) (p=0.04) vs. 8/23 (34.8%) (p=0.01). Among girls with PCOS, those with OSA had significantly higher proportions of metabolic syndrome (MetS) (9/16 (56.3%) vs. 1/12 (8.3%) p=0.03), higher insulin resistance (14/16 (87.5%) vs. 6/12 (50%), p=0.04), elevated daytime systolic blood pressure (128.4±12.8 vs. 115.6±11.4, p<0.01), lower high-density lipoprotein (HDL) (38.6±8.7 vs. 49±10.9, p=0.01) and elevated triglycerides (TG) (149.7±87.7 vs. 93.3±25.8, p=0.03) compared to those without OSA.
  
  
  CONCLUSIONS
  We report a higher prevalence of OSA and metabolic dysfunction in a selected group of obese girls with PCOS referred with sleep-related complaints compared to BMI-matched control girls without PCOS. We also report higher prevalence of cardiometabolic dysfunction in girls with PCOS and OSA compared to girls with PCOS without OSA.
authors.affiliation: Division of Respiratory and Sleep Medicine, Department of Pediatrics, Children's Hospital at Montefiore, B3415 Bainbridge Avenue, ronx, NY10467, USA.
authors.forename: Kiran
authors.initials: K
authors.lastname: Nandalike
authors.forename: Chhavi
authors.initials: C
authors.lastname: Agarwal
authors.forename: Temima
authors.initials: T
authors.lastname: Strauss
authors.forename: Susan M
authors.initials: SM
authors.lastname: Coupey
authors.forename: Carmen R
authors.initials: CR
authors.lastname: Isasi
authors.forename: Sanghun
authors.initials: S
authors.lastname: Sin
authors.forename: Raanan
authors.initials: R
authors.lastname: Arens
mesh_terms: D000293:Adolescent; D015992:Body Mass Index; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D007333:Insulin Resistance / Q000502:physiology; D008297:Male; D024821:Metabolic Syndrome / Q000209:etiology; D009765:Obesity / Q000150:complications* / Q000503:physiopathology; D011085:Polycystic Ovary Syndrome / Q000150:complications* / Q000503:physiopathology; D017286:Polysomnography; D012189:Retrospective Studies; D012737:Sex Factors; D012890:Sleep / Q000502:physiology*; D020181:Sleep Apnea, Obstructive / Q000209:etiology