title: Adjustment of gut hormones release pattern following a fixed mealtime change in human.
abstract: BACKGROUND
  Gut hormones secretion is related to habitual mealtimes. However, how fast gut hormones adjust to that change when people change their fixed mealtime remains unknown.
  
  
  METHODS
  Seven healthy male volunteers were asked to eat a test breakfast at 0700 am for 2 weeks before the start of the study. Then, their fixed mealtime was intentionally changed from 0700 am to 0900 am for next 2 weeks. Blood samples were drawn every half hour from 0500 am until next 3h after breakfast for determining gut hormone levels every week.
  
  
  RESULTS
  After a change in fixed mealtime, the release pattern of acylated ghrelin was first adjusted identically according to the change and then total ghrelin was made. The meal-related fluctuations of acylated ghrelin were delayed by 120 min from week 1 after the change, while those of total ghrelin were delayed by 60 min at week 1, by 120 min at week 2. Two weeks was not enough time to adjust completely for PYY(3-36) to the change.
  
  
  CONCLUSIONS
  Two weeks is enough time until the pattern release of ghrelin, but not PYY(3-36) , is adjusted fully after a fixed mealtime change in human.
authors.affiliation: Department of Laboratory Medicine, Pusan National University School of Medicine, Yansan 626-780, South Korea.
authors.forename: Hyoung Hoi
authors.initials: HH
authors.lastname: Kim
authors.forename: Tae Yong
authors.initials: TY
authors.lastname: Jeon
authors.forename: Yun Jin
authors.initials: YJ
authors.lastname: Kim
authors.forename: Sang Yeoup
authors.initials: SY
authors.lastname: Lee
authors.forename: Jeong Gyu
authors.initials: JG
authors.lastname: Lee
authors.forename: Dong Wook
authors.initials: DW
authors.lastname: Jeong
authors.forename: Yu Hyone
authors.initials: YH
authors.lastname: Yi
authors.forename: Young Hye
authors.initials: YH
authors.lastname: Cho
authors.forename: Eun Jung
authors.initials: EJ
authors.lastname: Choi
authors.forename: Kyung Jee
authors.initials: KJ
authors.lastname: Nam
authors.forename: Young Jin
authors.initials: YJ
authors.lastname: Tak
mesh_terms: D000328:Adult; D015992:Body Mass Index; D062408:Breakfast; D005768:Gastrointestinal Hormones / Q000097:blood / Q000378:metabolism*; D054439:Ghrelin / Q000378:metabolism; D006801:Humans; D008297:Male; D010446:Peptide Fragments; D019894:Peptide YY / Q000378:metabolism; D012016:Reference Values; D013997:Time Factors; D055815:Young Adult
chemical_list: D005768:Gastrointestinal Hormones; D054439:Ghrelin; D010446:Peptide Fragments; D019894:Peptide YY; C061785:peptide YY (3-36)