title: Catechol-O-methyltransferase genetic variant associated with the risk of Alzheimer's disease in a Brazilian population.
abstract: The aim of the present study was to examine the association between polymorphism in the catechol-O-methyltransferase(COMT) gene and Alzheimer's disease (AD) in a Brazilian population. The case-control method was used to study the association between AD and genetic variants of COMT. Six tag single-nucleotide polymorphisms(SNPs) in the COMT gene were genotyped by RT-PCR. Our findings showed that the 6 tag SNPs analyzed in this study were not associated with AD at the allele and genotype levels in comparison with the control group. No statistical difference was found between groups with and without behavioral and psychological symptoms of dementia (BPSD). Our results do not support the hypothesis that the polymorphisms of the COMT gene may be associated with susceptibility to AD with and without BPSD.
authors.affiliation: INCT - de Medicina Molecular, Faculdade de Medicina,Universidade Federal de Minas Gerais, Belo Horizonte, Brazil. patriciabiomol@yahoo.com.br
authors.forename: Patricia Araújo
authors.initials: PA
authors.lastname: Pereira
authors.forename: Marco Aurélio
authors.initials: MA
authors.lastname: Romano-Silva
authors.forename: Maria Aparecida Camargos
authors.initials: MA
authors.lastname: Bicalho
authors.forename: Edgar Nunes
authors.initials: EN
authors.lastname: de Moraes
authors.forename: Leandro
authors.initials: L
authors.lastname: Malloy-Diniz
authors.forename: Guilherme José Garcia Santos
authors.initials: GJ
authors.lastname: Pimenta
authors.forename: Marina Pena
authors.initials: MP
authors.lastname: Mello
authors.forename: Isadora Cristine Reis Sguizzato
authors.initials: IC
authors.lastname: Bozzi
authors.forename: Luiz Armando
authors.initials: LA
authors.lastname: de Marco
authors.forename: Rodrigo
authors.initials: R
authors.lastname: Nicolato
authors.forename: Debora Marques
authors.initials: DM
authors.lastname: Miranda
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000235:genetics* / Q000523:psychology; D001938:Brazil; D016022:Case-Control Studies; D002394:Catechol O-Methyltransferase / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006239:Haplotypes; D006801:Humans; D008297:Male; D020641:Polymorphism, Single Nucleotide; D044382:Population Groups / Q000235:genetics; D060888:Real-Time Polymerase Chain Reaction
chemical_list: D002394:Catechol O-Methyltransferase