title: α-Iso-cubebene, a natural compound isolated from Schisandra chinensis fruit, has therapeutic benefit against polymicrobial sepsis.
abstract: α-Iso-cubebene, a natural compound isolated from Schisandra chinensis fruit, strongly enhanced survival rate in cecal ligation and puncture (CLP) challenge-induced sepsis. The mechanism involved the marked reduction of viable bacteria in the peritoneal fluid, by virtue of increased phagocytic activity and production of hydrogen peroxide. α-Iso-cubebene also significantly attenuated lung inflammation and widespread immune cell apoptosis in a mouse CLP sepsis model, and inhibited the production of proinflammatory cytokines including tumor necrosis factor-α, interleukin (IL)-1β, and IL-6 in CLP mice and lipopolysaccharide-stimulated splenocytes. The results indicate that α-iso-cubebene can reverse the progression of toxic shock by triggering multiple protective downstream signaling pathways to enhance microbial killing and maintain organ function and leukocyte survival.
authors.affiliation: Department of Biological Sciences, Sungkyunkwan University, Suwon 440-746, South Korea.
authors.forename: Sung Kyun
authors.initials: SK
authors.lastname: Lee
authors.forename: Sang Doo
authors.initials: SD
authors.lastname: Kim
authors.forename: Ha Young
authors.initials: HY
authors.lastname: Lee
authors.forename: Suk-Hwan
authors.initials: SH
authors.lastname: Baek
authors.forename: Min Jung
authors.initials: MJ
authors.lastname: Ko
authors.forename: Beung Gu
authors.initials: BG
authors.lastname: Son
authors.forename: Sejin
authors.initials: S
authors.lastname: Park
authors.forename: Young Whan
authors.initials: YW
authors.lastname: Choi
authors.forename: Yoe-Sik
authors.initials: YS
authors.lastname: Bae
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000302:isolation & purification / Q000627:therapeutic use*; D017209:Apoptosis / Q000187:drug effects; D001419:Bacteria / Q000187:drug effects; D001688:Biological Products / Q000302:isolation & purification / Q000627:therapeutic use*; D016207:Cytokines / Q000037:antagonists & inhibitors; D004195:Disease Models, Animal; D008214:Lymphocytes / Q000187:drug effects; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D018410:Pneumonia, Bacterial / Q000188:drug therapy / Q000276:immunology / Q000382:microbiology; D032141:Schisandra / Q000737:chemistry*; D018805:Sepsis / Q000188:drug therapy* / Q000276:immunology / Q000382:microbiology; D012717:Sesquiterpenes / Q000302:isolation & purification / Q000627:therapeutic use*; D012772:Shock, Septic / Q000188:drug therapy / Q000276:immunology
chemical_list: D000900:Anti-Bacterial Agents; D001688:Biological Products; D016207:Cytokines; D012717:Sesquiterpenes; C539088:alpha-iso-cubebene