title: Chromatographic-nuclear magnetic resonance can provide a prediction of high-pressure liquid chromatography shape selectivity tests.
abstract: NMR diffusometry has been recently demonstrated as a means of investigating the mobility variations of solutes induced by chromatographic phases (under the acronym chromatographic-NMR). Particularly, a given compound has its average diffusivity reduced proportionally to its affinity towards the solid. In this work we propose the first comparison of chromatographic-NMR and tests for assessment of column performance, to investigate to what measure the novel approach could provide an assay of the outcome of a given stationary phase without the need of packing the relative column. Specifically, using bulk materials, we reproduce with very good agreement a shape selectivity test as reported in the catalog of a column producer, consisting of four probe molecules, applied to two different stationary phases.
authors.affiliation: Ism2 UMR 7313, Aix Marseille Univ., Faculté des Sciences et Techniques de Saint-Jérôme, 13397 Marseille Cedex 20, France.
authors.forename: Caroline
authors.initials: C
authors.lastname: Carrara
authors.forename: Claire
authors.initials: C
authors.lastname: Lopez
authors.forename: Stefano
authors.initials: S
authors.lastname: Caldarelli
mesh_terms: D002851:Chromatography, High Pressure Liquid / Q000295:instrumentation / Q000379:methods*; D056148:Chromatography, Reverse-Phase / Q000379:methods; D004058:Diffusion; D016014:Linear Models; D009682:Magnetic Resonance Spectroscopy / Q000379:methods*; D008962:Models, Theoretical; D011084:Polycyclic Aromatic Hydrocarbons / Q000737:chemistry / Q000302:isolation & purification; D012822:Silicon Dioxide / Q000737:chemistry
chemical_list: D011084:Polycyclic Aromatic Hydrocarbons; D012822:Silicon Dioxide