title: Periampullary localized pancreatic intraepithelial neoplasia-3 (PanIN-3): evaluation with contrast-enhanced MR cholangiography (MRCP).
abstract: BACKGROUND
  The early determination of premalignant lesions of pancreas can prevent unnecessary excessive surgical procedures and can reduce morbidity and mortality. Pancreatic intraepithelial neoplasia-3 (PanIN-3) is a preinvasive form of adenocarcinoma (carcinoma in situ). PanINs have not taken place in the literature of radiology yet, it should be considered in differential diagnosis of pancreatic cystic lesions.
  
  
  METHODS
  A patient with preliminary diagnosis of chronic cholecystitis who had choledocolithiasis and periampullary pancreatic cyst detected by noncontrast-enhanced (NCE) and contrast-enhanced (CE) magnetic resonance cholangiography (MRCP) is presented. Pathological examination results of gallbladder and pancreatic cyst were reported as gallbladder adenocarcinoma and PanIN-3, respectively.
  
  
  CONCLUSIONS
  Pancreatic cystic lesions with thin septa which enhances slightly with the administration of contrast material may represent PanIN-3. In patients with cystic pancreatic lesion localized at periampullary region, using CE-MRCP together with NCE-MRCP could be useful in the evaluation of pancreatic cystic masses as well as other abdominal pathologies.
authors.affiliation: Department of Radiology, Atatürk Training and Research Hospital, Bilkent, Ankara, Turkey.
authors.forename: Oktay
authors.initials: O
authors.lastname: Algin
authors.forename: Evrim
authors.initials: E
authors.lastname: Ozmen
authors.forename: Pamir Eren
authors.initials: PE
authors.lastname: Ersoy
authors.forename: Mustafa
authors.initials: M
authors.lastname: Karaoglanoglu