title: Apicobasal polarity and cell proliferation during development.
abstract: Cell polarization and cell division are two fundamental cellular processes. The mechanisms that establish and maintain cell polarity and the mechanisms by which cells progress through the cell cycle are now fairly well understood following decades of experimental work. There is also increasing evidence that the polarization state of a cell affects its proliferative properties. The challenge now is to understand how these two phenomena are mechanistically connected. The aim of the present chapter is to provide an overview of the evidence of cross-talk between apicobasal polarity and proliferation, and the current state of knowledge of the precise mechanism by which this cross-talk is achieved.
authors.affiliation: Faculty of Life Sciences, Michael Smith Building, University of Manchester, Oxford Road, Manchester M13 9PT, U.K. Nitin.Sabherwal@manchester.ac.uk
authors.forename: Nitin
authors.initials: N
authors.lastname: Sabherwal
authors.forename: Nancy
authors.initials: N
authors.lastname: Papalopulu
mesh_terms: D000818:Animals; D016764:Cell Polarity; D049109:Cell Proliferation; D055495:Neurogenesis; D015398:Signal Transduction