title: Right ventricular structure is associated with the risk of heart failure and cardiovascular death: the Multi-Ethnic Study of Atherosclerosis (MESA)--right ventricle study.
abstract: BACKGROUND
  Changes in right ventricular (RV) morphology are associated with morbidity and mortality in heart and lung disease. We examined the association of abnormal RV structure and function with the risk of heart failure or cardiovascular death in a population-based multiethnic sample free of clinical cardiovascular disease at baseline.
  
  
  RESULTS
  The Multi-Ethnic Study of Atherosclerosis (MESA) performed cardiac magnetic resonance imaging on 5098 participants between 2000 and 2002 with follow-up for incident heart failure and cardiovascular death ("death") until January 2008. RV volumes and mass were available for 4204 participants. The study sample (n=4144) was 61.4±10.1 years old and 47.6% male. The presence of RV hypertrophy (increased RV mass) was associated with more than twice the risk of heart failure or death after adjustment for demographics, body mass index, education, C-reactive protein level, hypertension, and smoking status (hazard ratio, 2.52; 95% confidence interval, 1.55-4.10; P<0.001) and a doubling (or more) of risk with left ventricular mass at the mean value or lower (P for interaction=0.05).
  
  
  CONCLUSIONS
  RV hypertrophy was associated with the risk of heart failure or death in a multiethnic population free of clinical cardiovascular disease at baseline.
authors.affiliation: Penn Cardiovascular Institute, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, USA.kawut@upenn.edu
authors.forename: Steven M
authors.initials: SM
authors.lastname: Kawut
authors.forename: R Graham
authors.initials: RG
authors.lastname: Barr
authors.forename: João A C
authors.initials: JA
authors.lastname: Lima
authors.forename: Amy
authors.initials: A
authors.lastname: Praestgaard
authors.forename: W Craig
authors.initials: WC
authors.lastname: Johnson
authors.forename: Harjit
authors.initials: H
authors.lastname: Chahal
authors.forename: Kofo O
authors.initials: KO
authors.lastname: Ogunyankin
authors.forename: Michael R
authors.initials: MR
authors.lastname: Bristow
authors.forename: Jorge R
authors.initials: JR
authors.lastname: Kizer
authors.forename: Harikrishna
authors.initials: H
authors.lastname: Tandri
authors.forename: David A
authors.initials: DA
authors.lastname: Bluemke
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D015331:Cohort Studies; D003324:Coronary Artery Disease / Q000208:ethnology* / Q000401:mortality / Q000473:pathology*; D003643:Death; D005006:Ethnicity / Q000208:ethnology; D005260:Female; D005500:Follow-Up Studies; D006333:Heart Failure / Q000208:ethnology* / Q000401:mortality / Q000473:pathology*; D006352:Heart Ventricles / Q000473:pathology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies