title: Two-fold modification of the phenyl substituent in phenylphosphonic acid monoester monoamides.
abstract: Phenylphosphonic acid ethyl ester N,N-diethylamide was subjected to a double modification of its phenyl substituent through directed ortho-metalation followed by dearomatization of the aryl substituent under Birch reduction conditions. Application of the same methodology to a diastereomerically pure phenylphosphonic acid monoester monoamide led to the formation of P-stereogenic cyclohexadienyl-phosphonic acid derivatives. The method offers a simple and efficient modification of phenyl substituent in organophosphorus compounds.
authors.affiliation: Department of Organic Chemistry, Faculty of Chemistry, Marie Curie-Skłodowska University, Gliniana 33, 20-614 Lublin, Poland. marek.stankevic@poczta.umcs.lublin.pl
authors.forename: Marek
authors.initials: M
authors.lastname: Stankevič
authors.forename: Jolanta
authors.initials: J
authors.lastname: Bazan