title: Contribution of toll-like receptor 9 gene single-nucleotide polymorphism to systemic lupus erythematosus.
abstract: There are several studies on the association of TLR9 polymorphisms with systemic lupus erythematosus (SLE) in different ethnicities; however, the results are inconsistent. Therefore, we studied the distribution of the TLR9 C > T (rs352140) polymorphism in patients with SLE (n = 254) and controls (n = 521) in a Polish population. We did not observe significant differences in the prevalence of the TLR9 C > T genotype and alleles between patients with SLE and controls. However, we found a contribution of the T/T and T/C genotypes to renal [OR = 2.949 (95 % CI = 1.523-5.711, p = 0.001), (p corr = 0.017)] and immunologic disorders [OR = 2.938 (95 % CI 1.500-5.755, p = 0.0012), (p corr = 0.0204)] in SLE patients. Moreover, we observed a significant association between the TLR9 T/T and T/C genotypes and the presence of anti-dsDNA Ab [OR = 3.682 (1.647-8.230, p = 0.001), (p corr = 0.017)]. Our studies suggest that the TLR9 C > T (rs352140) polymorphism might contribute to renal and immunologic disorders and to the presence of anti-dsDNA Ab.
authors.affiliation: Department of Biochemistry and Molecular Biology, Poznań University of Medical Sciences, 6 Święcickiego St., 60-781 Poznan, Poland.
authors.forename: Piotr
authors.initials: P
authors.lastname: Piotrowski
authors.forename: Margarita
authors.initials: M
authors.lastname: Lianeri
authors.forename: Mariusz
authors.initials: M
authors.lastname: Wudarski
authors.forename: Marzena
authors.initials: M
authors.lastname: Olesińska
authors.forename: Paweł P
authors.initials: PP
authors.lastname: Jagodziński
mesh_terms: D000328:Adult; D000974:Antibodies, Antinuclear / Q000097:blood; D015415:Biomarkers / Q000097:blood; D016022:Case-Control Studies; D016009:Chi-Square Distribution; D004247:DNA / Q000276:immunology; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000235:genetics* / Q000276:immunology; D008875:Middle Aged; D016017:Odds Ratio; D010641:Phenotype; D011044:Poland; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors; D051217:Toll-Like Receptor 9 / Q000235:genetics*
chemical_list: D000974:Antibodies, Antinuclear; D015415:Biomarkers; C495371:TLR9 protein, human; D051217:Toll-Like Receptor 9; D004247:DNA