title: [Massive hemorrhage of upper gastrointestinal tract caused by gastrointestinal stromal tumor of the stomach--case report].
abstract: BACKGROUND
  Acute bleeding from the upper gastrointestinal system is a medical emergency which is followed by high mortality rate, ranging from 6 to 15% in spite of modern diagnostic methods and treatment. Bleeding from the upper gastrointestinal system may be caused by gastrointestinal stromal tumors of the stomach, which are mainly characterized by occult bleeding, while profuse bleeding rarely occurs accompanied by hemorrhagic shock. Gastrointestinal stromal tumors of stomach are the most common mesenchimal tumors of the gastrointestinal tract.
  
  
  METHODS
  In our study we showed a 60-year-old female patient with profuse bleeding from the stomach and the clinical picture of severe hemorrhagic shock, caused by gastrointestinal stromal tumor. An ovoid junction, raised towards the lumen, covered with ulcerated mucosa in several places and followed by massive arterial bleeding was found intraoperatively, after the performed gastrotomy. Histopathological examination with immunohistochemical analysis confirmed that this was a gastrointestinal stromal tumor of the stomach.
  
  
  CONCLUSIONS
  Acute bleeding from the digestive system is a sudden and serious condition of the body. Urgent esophagogastroduodenoscopy is a sensitive and specific diagnostic and therapeutic method of choice. Massive bleeding from the upper gastrointestinal tract is very rarely caused by gastrointestinal stromal tumors, whose clinical picture is very heterogeneous and depends on tumor size and location. Abundant bleeding from the tumor is an indication for urgent surgical intervention.
  
  
  CONCLUSIONS
  According to the literature massive hemorrhage of the upper digestive system can rarely be caused by gastrointestinal stromal tumor of the stomach. It is shown that abundant hemorrhage of the upper digestive tract can be caused with gastric gastrointestinal stromal tumor. Surgical resection is the main form of treatment of gastrointestinal stromal tumors of the digestive system and bleeding from these tumors caused by failure of endoscopic hemostasis.
authors.affiliation: Druga hirurska klinikal Druga interna klinika. nenad.lalovic@gmail.com
authors.forename: Nenad
authors.initials: N
authors.lastname: Lalović
authors.forename: Nikolina
authors.initials: N
authors.lastname: Dukić Vladicić
authors.forename: Radmil
authors.initials: R
authors.lastname: Marić
authors.forename: Mirjana
authors.initials: M
authors.lastname: Cuk
authors.forename: Milan
authors.initials: M
authors.lastname: Simatović
authors.forename: Dragana
authors.initials: D
authors.lastname: Jokanović
mesh_terms: D005260:Female; D006471:Gastrointestinal Hemorrhage / Q000209:etiology*; D046152:Gastrointestinal Stromal Tumors / Q000150:complications*; D006801:Humans; D008875:Middle Aged; D012771:Shock, Hemorrhagic / Q000209:etiology; D013274:Stomach Neoplasms / Q000150:complications*