title: Young patient with acute ischemic stroke due to papillary carcinoma of the thyroid.
abstract: Hypercoagulability is a condition predisposing to arterial or venous thrombosis and is associated frequently with malignancy. We present a rare acute ischemic stroke in a young patient that was the presenting feature for a newly diagnosed papillary carcinoma of the thyroid. Extensive vascular and hematological work-up was normal except for a large patent foramen ovale (PFO). This finding, along with the association of most vascular events with hypercoagulability being of venous origin, makes the mechanism of paradoxical embolism through the large PFO the probable cause of stroke in our patient.
authors.affiliation: Department of Neurology, Rambam Health Care Campus and Technion Faculty of Medicine, Haifa, Israel. m_herskovitz@rambam.health.gov.il
authors.forename: Moshe
authors.initials: M
authors.lastname: Herskovitz
authors.forename: Efim
authors.initials: E
authors.lastname: Kouperberg
authors.forename: Michael M
authors.initials: MM
authors.lastname: Krausz
authors.forename: Gregory
authors.initials: G
authors.lastname: Telman
mesh_terms: D000328:Adult; D000925:Anticoagulants / Q000627:therapeutic use; D001014:Aortic Aneurysm / Q000473:pathology; D054087:Atrial Septum / Q000473:pathology; D044963:Biopsy, Fine-Needle; D002545:Brain Ischemia / Q000209:etiology* / Q000473:pathology; D002291:Carcinoma, Papillary / Q000150:complications* / Q000473:pathology; D017548:Echocardiography, Transesophageal; D005260:Female; D054092:Foramen Ovale, Patent / Q000473:pathology; D006495:Heparin, Low-Molecular-Weight / Q000627:therapeutic use; D006801:Humans; D012307:Risk Factors; D020521:Stroke / Q000209:etiology* / Q000473:pathology; D019851:Thrombophilia / Q000209:etiology*; D013964:Thyroid Neoplasms / Q000150:complications* / Q000473:pathology; D013965:Thyroidectomy; D014057:Tomography, X-Ray Computed
chemical_list: D000925:Anticoagulants; D006495:Heparin, Low-Molecular-Weight