title: Reductive cleavage of the Csp2-Csp3 bond of secondary benzyl alcohols: rhodium catalysis directed by N-containing groups.
abstract: Cutting loose: 1,1-Biarylmethanol substrates undergo reductive cleavage of the C-C bond in the presence of a cationic Rh(III) catalyst and H(2) (see scheme; DG=directing group). Various functional groups are tolerated in the reaction system. Preliminary studies indicate that a five-membered rhodacycle intermediate, which then converts into a Rh(III) hydride species for the reduction, is involved in the catalytic cycle.
authors.affiliation: Beijing National Laboratory of Molecule Science (BNLMS) and Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education, College of Molecular Engineering and Green Chemistry Center, Peking University, Beijing, China.
authors.forename: Kang
authors.initials: K
authors.lastname: Chen
authors.forename: Hu
authors.initials: H
authors.lastname: Li
authors.forename: Zhi-Quan
authors.initials: ZQ
authors.lastname: Lei
authors.forename: Yang
authors.initials: Y
authors.lastname: Li
authors.forename: Wen-He
authors.initials: WH
authors.lastname: Ye
authors.forename: Li-Sheng
authors.initials: LS
authors.lastname: Zhang
authors.forename: Jian
authors.initials: J
authors.lastname: Sun
authors.forename: Zhang-Jie
authors.initials: ZJ
authors.lastname: Shi
mesh_terms: D001592:Benzyl Alcohols / Q000737:chemistry*; D002384:Catalysis; D006865:Hydrogenation; D000432:Methanol / Q000031:analogs & derivatives; D010084:Oxidation-Reduction; D012238:Rhodium / Q000737:chemistry*
chemical_list: D001592:Benzyl Alcohols; D012238:Rhodium; D000432:Methanol