title: [Association between paraoxonase concentration and risk of acute coronary syndrome].
abstract: OBJECTIVE
  To investigate the relationship between paraoxonase (PON) concentration and the risk of acute coronary syndrome (ACS).
  
  
  METHODS
  The levels of serum PON were detected by enzyme-linked immunosorbent assay in 229 patients with confirmed ACS and 129 control subjects without CHD. Logistic regression analysis and receiver operating characteristic (ROC) curve analysis were applied to analyze the association between PON and ACS.
  
  
  RESULTS
  PON was significantly lower in ACS group than in control group [lgPON: (5.72 ± 0.73) ng/L vs. (5.07 ± 0.57) ng/L, P < 0.05]. Logistic regression analysis showed that the level of PON was an independent risk factor of ACS (regression coefficient was -1.793 in univariate logistic regression, OR = 0.166, 95%CI: 0.088 - 0.316; -0.779 in multivariate logistic regression, OR = 0.459, 95%CI: 0.222 - 0.949). ROC analysis showed that the optimal diagnostic cut-off point of PON for ACS was 180 mg/L (sensitivity: 83.3%, specificity: 71.2%). Multiple stepwise regression analysis revealed that there was no significant correlation between lgPON and Gensini score in ACS patients.
  
  
  CONCLUSIONS
  Lower PON is linked with increased risk of ACS, but does not relate with the severity of coronary stenosis.
authors.affiliation: Department of Cardiovascular Medicine, First Affiliated Hospital of Medical College and Institute of Cardiovascular Channelopathy, Key Laboratory of Environment and Genes Related to Diseases (Xi'an Jiaotong University), Ministry of Education, Key Laboratory of Molecular Cardiology, Xi'an 710061, China.
authors.forename: Qun
authors.initials: Q
authors.lastname: Lu
authors.forename: Gang
authors.initials: G
authors.lastname: Tian
authors.forename: Yong
authors.initials: Y
authors.lastname: Zhang
authors.forename: Min
authors.initials: M
authors.lastname: Lu
authors.forename: Ai-qun
authors.initials: AQ
authors.lastname: Ma
mesh_terms: D054058:Acute Coronary Syndrome / Q000097:blood*; D000368:Aged; D043303:Aryldialkylphosphatase / Q000097:blood*; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged
chemical_list: D043303:Aryldialkylphosphatase