title: [Clinicopathological characterization of true hermaphroditism complicated with seminoma and review of the literature].
abstract: OBJECTIVE
  To study the clinicopathological characteristics and diagnosis of true hermaphroditism complicated with seminoma.
  
  
  METHODS
  We retrospectively analyzed the clinicopathological data of a case of true hermaphroditism complicated with seminoma and reviewed the related literature.
  
  
  RESULTS
  The patient was a 42-year-old male, admitted for bilateral lower back pain and discomfort. CT showed a huge mass in the lower middle abdomen. Gross pathological examination revealed a mass of uterine tissue, 7 cm x 2 cm x 6 cm in size, with bilateral oviducts and ovarian tissue. There was a cryptorchidism (4.0 cm x 2.5 cm x 1.5 cm) on the left and a huge tumor (22 cm x9 cm x6 cm) on the right of the uterine tissue. The tumor was completely encapsulated, with some testicular tissue. Microscopically, the tumor tissue was arranged in nests or sheets divided and surrounded by fibrous tissue. The tumor cells were large, with abundant and transparent cytoplasm, deeply stained nuclei, coarse granular chromatins, visible mitosis, and infiltration of a small number of lymphocytes in the stroma. The karyotype was 46, XX. Immunohistochemistry showed that PLAP and CD117 were positive, while the AFP, Vimentin, EMA, S100, CK-LMW, Desmin, CD34 and CD30 were negative, and Ki-67 was 20% positive. A small amount of residual normal testicular tissue was seen in the tumor tissue.
  
  
  CONCLUSIONS
  True hermaphroditism complicated with seminoma is rare. Histopathological analysis combined with immunohistochemical detection is of great value for its diagnosis and differential diagnosis.
authors.affiliation: Department of Pathology, The Fourth Affiliated Hospital of Jinan University/Guangzhou Red Cross Hospital, Guangzhou, Guangdong 510220, China.
authors.forename: Xing
authors.initials: X
authors.lastname: Hua
authors.forename: Shao-Jie
authors.initials: SJ
authors.lastname: Liu
authors.forename: Lin
authors.initials: L
authors.lastname: Lu
authors.forename: Chao-Xia
authors.initials: CX
authors.lastname: Li
authors.forename: Li-Na
authors.initials: LN
authors.lastname: Yu
mesh_terms: D000328:Adult; D006801:Humans; D008297:Male; D050090:Ovotesticular Disorders of Sex Development / Q000150:complications / Q000473:pathology*; D012189:Retrospective Studies; D018239:Seminoma / Q000150:complications / Q000473:pathology*; D013736:Testicular Neoplasms / Q000150:complications / Q000473:pathology*