title: Effects of salidroside on exhaustive exercise‑induced oxidative stress             in rats.
abstract: Intense exercise increases oxygen consumption and may produce an imbalance             between reactive oxygen species (ROS) and antioxidants, inducing oxidative stress             as a result of increased ROS production. Exogenous antioxidants may prevent oxidative             damages since they are able to detoxify certain peroxides by scavenging the ROS             produced during exercise. The aim of this study was to evaluate the effects of             salidroside on exhaustive exercise-induced oxidative stress in rats. A total of             40 animals were randomly divided into four groups of ten rats each: control (C),             low-dose salidroside‑treated (LT), middle-dose salidroside-treated (MT) and high-dose             salidroside-treated (HT) groups. The rats in the treated groups received salidroside             (25, 50 and 100 mg/kg, respectively) intragastrically (ig) and the rats in the             control group received drinking water ig for 4 weeks. After 4 weeks, the rats             performed an exhaustive swimming exercise and exhaustive swimming times were recorded.             The malondialdehyde (MDA), catalase (CAT), superoxide dismutase (SOD), glutathione             peroxidase (GSH-Px) and glycogen levels in the liver tissues of the rats were             measured. The data revealed that salidroside was able to elevate the exercise             tolerance and increase the liver glycogen levels of the rats following exhaustive             exercise. Salidroside was also able to reduce MDA levels and enhance the activities             of antioxidant enzymes (CAT, SOD and GSH-Px) in the liver tissues of the rats.             The results from this study indicate that salidroside is effective in the prevention             of oxidative stress following exhaustive exercise.
authors.affiliation: Department of Physical Education, Tianjin University, Tianjin 300072, PR China. jishxu@163.com
authors.forename: Jiansheng
authors.initials: J
authors.lastname: Xu
authors.forename: Ying
authors.initials: Y
authors.lastname: Li
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D002374:Catalase / Q000378:metabolism; D005960:Glucosides / Q000494:pharmacology*; D005979:Glutathione Peroxidase / Q000378:metabolism; D006003:Glycogen / Q000378:metabolism; D008099:Liver / Q000378:metabolism; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D018384:Oxidative Stress / Q000187:drug effects*; D010636:Phenols / Q000494:pharmacology*; D018517:Plant Roots / Q000737:chemistry; D051381:Rats; D017207:Rats, Sprague-Dawley; D029771:Rhodiola / Q000737:chemistry; D013482:Superoxide Dismutase / Q000378:metabolism; D013550:Swimming
chemical_list: D000975:Antioxidants; D005960:Glucosides; D010636:Phenols; D008315:Malondialdehyde; D006003:Glycogen; D002374:Catalase; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase; C009172:rhodioloside