title: Improved diabetes control and pancreatic function in a type 2 diabetic after omeprazole administration.
abstract: A 43-year-old man with type 2 diabetes, opposed to insulin use and poorly responsive to oral agents added sequentially over 6 years, was placed on 40 mg omeprazole twice daily. A linear decline in daily fasting blood glucose was observed over the first two-month treatment, and his hemoglobin A1c was reduced from 11.9% to 8.2%, then sustained at 8.1% after four months. Glucose, insulin, and C-peptide response to a 2-hour glucose tolerance test were consistently improved across this time period, and calculated beta-cell mass increased by 67%. We believe these responses are consistent with activation or neogenesis of pancreatic beta cells, possibly through a gastrin-mediated mechanism.
authors.affiliation: Fort Bend Premier Care, 1505 Liberty Street, Richmond, TX 77469, USA.
authors.forename: I N
authors.initials: IN
authors.lastname: Mefford
authors.forename: J T
authors.initials: JT
authors.lastname: Mefford
authors.forename: C A
authors.initials: CA
authors.lastname: Burris