title: Treatment of Aggressive NK-Cell Leukemia: A Case Report and Review of the Literature.
abstract: Aggressive NK-cell leukemia is a rare malignancy with neoplastic proliferation of natural killer cells. It often presents with constitutional symptoms, a rapid declining clinical course, and a poor prognosis with a median survival of a few months. The disease is usually resistant to cytotoxic agents, and no treatment has emerged as the standard of care for these patients. We report a case of an 18-year-old male who obtains complete remission following two lines of combination chemotherapy. We describe in details our regimens for induction chemotherapy and perform a review of existing literature concerning treatment of aggressive NK-cell leukemia.
authors.affiliation: Department of Hematology, Aalborg Hospital, Aarhus University Hospital, Hobrovej 18-22, P.O. Box 365, 9100 Aalborg, Denmark.
authors.forename: Anders Kindberg
authors.initials: AK
authors.lastname: Boysen
authors.forename: Paw
authors.initials: P
authors.lastname: Jensen
authors.forename: Preben
authors.initials: P
authors.lastname: Johansen
authors.forename: Karen
authors.initials: K
authors.lastname: Dybkær
authors.forename: Mette
authors.initials: M
authors.lastname: Nyegaard