title: An infant with human parechovirus type 3 infection with a distinctive rash on the extremities.
abstract: Human parechovirus type 3 (HPeV3) is known to cause sepsis-like syndrome and meningoencephalitis in neonates and young infants. We herein report a neonatal case of sepsis-like syndrome due to HPeV3 infection, diagnosed using polymerase chain reaction (PCR), with a distinctive erythematous rash present mainly on the soles and palms that helped in the diagnosis of the disease. Combining the unique characteristics of rash and confirmation by PCR at the early stage of the disease led to the diagnosis of HPeV3, distinguishing it from sepsis and other critical disease conditions, and allowing for appropriate, rapid management.
authors.affiliation: Division of Infectious Disease, Department of Medical Subspecialties, National Center for Child Health and Development, Tokyo, JapanDivision of General Pediatrics, Department of Interdisciplinary Medicine, National Center for Child Health and Development, Tokyo, Japan.
authors.forename: Kensuke
authors.initials: K
authors.lastname: Shoji
authors.forename: Hisako
authors.initials: H
authors.lastname: Komuro
authors.forename: Yoshinori
authors.initials: Y
authors.lastname: Kobayashi
authors.forename: Tatsuhiko
authors.initials: T
authors.lastname: Shike
authors.forename: Takanori
authors.initials: T
authors.lastname: Funaki
authors.forename: Tomohiro
authors.initials: T
authors.lastname: Katsuta
authors.forename: Ippei
authors.initials: I
authors.lastname: Miyata
authors.forename: Akihiko
authors.initials: A
authors.lastname: Saitoh
mesh_terms: D003937:Diagnosis, Differential; D005076:Exanthema / Q000821:virology*; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D030061:Parechovirus / Q000302:isolation & purification*; D010850:Picornaviridae Infections / Q000175:diagnosis* / Q000821:virology*