title: Utility of serum and urine uPAR levels for diagnosis of breast cancer.
abstract: Malignant tumors have a capacity to degrade the extracellular matrix by controlled proteolysis. One system involved in these processes is the urokinase-type plasminogen activator (uPA) system. uPAR levels are elevated in tumors from several types of cancer. Our study was planned to investigate serum and urine levels of uPAR in breast cancer patients (n=180) and healthy controls (n=60) by ELISA. Serum (p<0.001) and urine (p<0.001) uPAR values in the patients were both significantly elevated. High serum and urine levels of uPAR can be used as diagnostic tools in lymph node positive patients.
authors.affiliation: Basic Oncology Department, Oncology Institute, Istanbul University, Istanbul, Turkey.
authors.forename: Hilal Oguz
authors.initials: HO
authors.lastname: Soydinc
authors.forename: Derya
authors.initials: D
authors.lastname: Duranyildiz
authors.forename: Nese
authors.initials: N
authors.lastname: Guney
authors.forename: Duygu
authors.initials: D
authors.lastname: Derin
authors.forename: Vildan
authors.initials: V
authors.lastname: Yasasever
mesh_terms: D000328:Adult; D000368:Aged; D014408:Biomarkers, Tumor / Q000097:blood / Q000652:urine; D001943:Breast Neoplasms / Q000097:blood / Q000175:diagnosis* / Q000652:urine; D005260:Female; D006801:Humans; D008207:Lymphatic Metastasis; D008875:Middle Aged; D011379:Prognosis; D014568:Urokinase-Type Plasminogen Activator / Q000097:blood* / Q000652:urine*
chemical_list: D014408:Biomarkers, Tumor; D014568:Urokinase-Type Plasminogen Activator