title: Nanoscale arrangement of proteins by single-molecule cut-and-paste.
abstract: Protein-based nanostructures are key to the organization of life and it is their precise arrangement, which determines their specific functions. A single-molecule approach for the directed assembly of protein arrangements allows for a controlled composition of systems based on protein components. Applying antibodies and antigenic peptide tags we utilized the Single-Molecule Cut-and-Paste (SMC&P) technique for the handling of single proteins. Protein-DNA complexes could be arranged to complex patterns with the functionality of the protein part remaining unimpaired.
authors.affiliation: Center for Nanoscience and Department of Physics, University of Munich, Amalienstrasse 54, 80799 Munich, Germany.
authors.forename: Mathias
authors.initials: M
authors.lastname: Strackharn
authors.forename: Diana A
authors.initials: DA
authors.lastname: Pippig
authors.forename: Philipp
authors.initials: P
authors.lastname: Meyer
authors.forename: Stefan W
authors.initials: SW
authors.lastname: Stahl
authors.forename: Hermann E
authors.initials: HE
authors.lastname: Gaub
mesh_terms: D053758:Nanoparticles; D011506:Proteins / Q000737:chemistry*
chemical_list: D011506:Proteins