title: Protein tyrosine phosphatases in health and disease.
abstract: Protein tyrosine phosphatases (PTPs) represent a super-family of enzymes that play essential roles in normal development and physiology. In this review, we will discuss the PTPs that have a causative role in hereditary diseases in humans. In addition, recent progress in the development and analysis of animal models expressing mutant PTPs will be presented. The impact of PTP signaling on health and disease will be exemplified for the fields of bone development, synaptogenesis and central nervous system diseases. Collectively, research on PTPs since the late 1980's yielded the cogent view that development of PTP-directed therapeutic tools is essential to further combat human disease.
authors.affiliation: Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands.
authors.forename: Wiljan J A J
authors.initials: WJ
authors.lastname: Hendriks
authors.forename: Ari
authors.initials: A
authors.lastname: Elson
authors.forename: Sheila
authors.initials: S
authors.lastname: Harroch
authors.forename: Rafael
authors.initials: R
authors.lastname: Pulido
authors.forename: Andrew
authors.initials: A
authors.lastname: Stoker
authors.forename: Jeroen
authors.initials: J
authors.lastname: den Hertog
mesh_terms: D000818:Animals; D001846:Bone Development / Q000235:genetics; D002493:Central Nervous System Diseases / Q000201:enzymology / Q000235:genetics; D004195:Disease Models, Animal; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D006801:Humans; D009154:Mutation; D017027:Protein Tyrosine Phosphatases / Q000235:genetics* / Q000378:metabolism; D015398:Signal Transduction / Q000235:genetics*; D013569:Synapses / Q000201:enzymology / Q000378:metabolism
chemical_list: D017027:Protein Tyrosine Phosphatases