title: FeCl3·6H2O-catalyzed alkenylation of indoles with aldehydes.
abstract: FeCl(3)·6H(2)O-catalyzed efficient C3-alkenylation of indoles was realized through the condensation of aldehydes and indole derivatives in the presence of 2 equiv of ethanol at ambient temperature, forming 3-vinylindoles in up to 93% yields. Ethanol promoted formation of the desired products. An obvious solvent effect was observed, and bisindoles were identified as the reaction intermediates.
authors.affiliation: Dalian Institute of Chemical Physics, Chinese Academy of Sciences, 457 Zhongshan Road, Dalian, Liaoning 116023, China.
authors.forename: Qin
authors.initials: Q
authors.lastname: Yang
authors.forename: Liandi
authors.initials: L
authors.lastname: Wang
authors.forename: Tenglong
authors.initials: T
authors.lastname: Guo
authors.forename: Zhengkun
authors.initials: Z
authors.lastname: Yu
mesh_terms: D000447:Aldehydes / Q000737:chemistry*; D000478:Alkylation; D002384:Catalysis; D002712:Chlorides / Q000737:chemistry*; D005290:Ferric Compounds / Q000737:chemistry*; D007211:Indoles / Q000737:chemistry*; D015394:Molecular Structure
chemical_list: D000447:Aldehydes; D002712:Chlorides; D005290:Ferric Compounds; D007211:Indoles; C024555:ferric chloride