title: Steroidal and phenolic glycosides from the bulbs of Lilium pumilum DC and their potential Na+/K+ ATPase inhibitory activity.
abstract: A new steroidal saponin, named pumilum A (1), and a new phenolic glycoside, threo-1-(4'-hydroxy-2'-methoxyphenyl)-2-(2",4"-dihydroxyphenyl)-1,3-propanediol-4'-O-β-D-glucopyranoside (7) were isolated from the methanolic extract of the bulbs of Lilium pumilum DC, along with five known steroidal saponins. Their chemical structures were elucidated on the basis of detailed spectroscopic analysis, including 1D and 2D NMR techniques and chemical methods. In addition, the inhibitory activity of all the isolates on Na(+)/K(+) ATPase was evaluated.
authors.affiliation: Chemistry Science and Technology School, Zhanjiang Normal University, 29 Cunjin Road, Zhanjiang 524048, China. zhanghualing303@163.com
authors.forename: Zhong-Liu
authors.initials: ZL
authors.lastname: Zhou
authors.forename: Zong-Cai
authors.initials: ZC
authors.lastname: Feng
authors.forename: Chun-Yan
authors.initials: CY
authors.lastname: Fu
authors.forename: Hua-Lin
authors.initials: HL
authors.lastname: Zhang
authors.forename: Jing-Min
authors.initials: JM
authors.lastname: Xia
mesh_terms: D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D004791:Enzyme Inhibitors / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D006027:Glycosides / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D027762:Lilium / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology; D018517:Plant Roots / Q000737:chemistry*; D000254:Sodium-Potassium-Exchanging ATPase / Q000037:antagonists & inhibitors*
chemical_list: D004365:Drugs, Chinese Herbal; D004791:Enzyme Inhibitors; D006027:Glycosides; D010936:Plant Extracts; D000254:Sodium-Potassium-Exchanging ATPase