title: Protective effects of taurine against alloxan-induced diabetic cataracts and refraction changes in New Zealand White rabbits.
abstract: The present study examined the protective effects of taurine on alloxan-induced diabetic cataracts and lens damage in male New Zealand White rabbits. The animals were randomly divided into three treatment groups: (1) normal control (vehicle administration); (2) diabetes (100 mg/kg alloxan administration); and (3) diabetes + taurine (1% [w/v] taurine dissolved in drinking water and alloxan administration). The results showed that alloxan-induced diabetes caused significant (p < 0.05) hyperglycemia, hyperopic refraction shifts, cataract formation and lens damage compared with the normal control group. In contrast, the administration of taurine for 24 weeks significantly ameliorated the alloxan-induced elevated levels of blood glucose, level of hyperopic refraction error shifts in the eyes and progression of diabetic cataract formation in the lens in rabbits. Moreover, histopathology showed that the taurine supplement reduced the incidence of lens lesions induced by hyperglycemia. Overall, the studies demonstrate that taurine exhibits potent protective effects against alloxan-induced diabetic cataracts and refraction changes in rabbits.
authors.affiliation: School of Optometry, Chung Shan Medical University, No. 110, Sec. 1, Jianguo N. Rd., Taichung City 402, Taiwan, ROC.
authors.forename: Yu-Wen
authors.initials: YW
authors.lastname: Hsu
authors.forename: Shang-Min
authors.initials: SM
authors.lastname: Yeh
authors.forename: Ya-Yu
authors.initials: YY
authors.lastname: Chen
authors.forename: Yi-Chen
authors.initials: YC
authors.lastname: Chen
authors.forename: Shiun-Long
authors.initials: SL
authors.lastname: Lin
authors.forename: Jung-Kai
authors.initials: JK
authors.lastname: Tseng
mesh_terms: D000496:Alloxan; D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D001835:Body Weight / Q000187:drug effects; D002386:Cataract / Q000139:chemically induced / Q000473:pathology / Q000517:prevention & control*; D003921:Diabetes Mellitus, Experimental / Q000139:chemically induced / Q000473:pathology / Q000517:prevention & control*; D006943:Hyperglycemia / Q000139:chemically induced / Q000175:diagnosis / Q000517:prevention & control; D006956:Hyperopia / Q000139:chemically induced / Q000175:diagnosis / Q000517:prevention & control*; D008297:Male; D011817:Rabbits; D012029:Refraction, Ocular / Q000187:drug effects; D042262:Retinoscopy; D013654:Taurine / Q000494:pharmacology*
chemical_list: D001786:Blood Glucose; D013654:Taurine; D000496:Alloxan