title: Synthesis and pharmacological investigation of 5-substituted-3-methylsulfanyl-1H-pyrazole-4-carboxylic acid ethyl esters as new analgesic and anti-inflammatory agents.
abstract: OBJECTIVE
  To synthesize a new series of 5-substituted-3-methylsulfanyl-1H-pyrazole-4-carboxylic acid ethyl esters for their analgesic and anti-inflammatory activity.
  
  
  METHODS
  The title compound synthesized by reacting the amino group of 5-amino-3-methylsulfanyl-1H-pyrazole-4-carboxylic acid ethyl ester with acid anhydrides, acid chlorides and phenyl dithiocarbamates. The synthesized compounds were characterized by IR, 1H-NMR and mass spectral data; the purity of the compounds was determined by elemental analysis. The title compounds were investigated for analgesic, anti-inflammatory and ulcerogenic behaviour.
  
  
  RESULTS
  The compound 5-benzoylamino-3-methylsulfanyl-1-phenyl-1H-pyrazole-4-carboxylic acid ethyl ester (4c) emerged as the most active compound and exhibiting imperative analgesic and anti-inflammatory activities. Interestingly the test compounds showed only mild ulcerogenic potential when compared to indomethacin.
  
  
  CONCLUSIONS
  The compound (4c) could serve as a lead molecule for further modification to obtain a clinically useful novel class of analgesic and anti-inflammatory agents.
authors.affiliation: Department of Pharmaceutical Chemistry, Vinayaka Mission's College of Pharmacy, Sankari Main Road, Ariyanoor, Salem, India. gokulakila@yahoo.co.in
authors.forename: P D
authors.initials: PD
authors.lastname: Gokulan
authors.forename: B
authors.initials: B
authors.lastname: Jayakar
authors.forename: V
authors.initials: V
authors.lastname: Alagarsamy
authors.forename: V
authors.initials: V
authors.lastname: Raja Solomon
mesh_terms: D000700:Analgesics / Q000009:adverse effects / Q000138:chemical synthesis* / Q000494:pharmacology; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects / Q000138:chemical synthesis* / Q000494:pharmacology; D002351:Carrageenan; D005260:Female; D005750:Gastric Juice / Q000378:metabolism; D007202:Indicators and Reagents; D007249:Inflammation / Q000139:chemically induced / Q000188:drug therapy; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D051379:Mice; D010147:Pain Measurement; D011720:Pyrazoles / Q000009:adverse effects / Q000138:chemical synthesis* / Q000494:pharmacology; D051381:Rats; D011930:Reaction Time / Q000187:drug effects; D013276:Stomach Ulcer / Q000139:chemically induced / Q000473:pathology; D013438:Sulfhydryl Compounds / Q000009:adverse effects / Q000138:chemical synthesis* / Q000494:pharmacology
chemical_list: D000700:Analgesics; D000894:Anti-Inflammatory Agents, Non-Steroidal; D007202:Indicators and Reagents; D011720:Pyrazoles; D013438:Sulfhydryl Compounds; D002351:Carrageenan