title: Dietary restrictions and drug interactions with monoamine oxidase inhibitors: an update.
abstract: Monoamine oxidase inhibitors (MAOIs) are effective treatments for depression that has atypical features or that has failed to respond to other antidepressants. However, MAOIs are underused because clinicians are concerned about dietary and drug interactions with this class of medication. Hypertensive crisis and serotonin syndrome can occur in rare cases due to interactions between MAOIs and foods containing tyramine as well as interactions with serotonergic and sympathomimetic agents. A better understanding of the foods and drugs that can cause adverse reactions, as well as knowledge of newer MAOIs with mechanisms of action and delivery methods that reduce these risks, may help clinicians to consider the use of these medications, when appropriate, in their patients with depression.
authors.affiliation: Indiana Insitute for Personalized Medicine and Division of Clinical Pharmacology, Indiana University School of Medicine, Indianapolis, IN 46202, USA. dflockha@iupui.edu
authors.forename: David A
authors.initials: DA
authors.lastname: Flockhart
mesh_terms: D000279:Administration, Cutaneous; D000284:Administration, Oral; D000928:Antidepressive Agents / Q000008:administration & dosage / Q000009:adverse effects*; D003866:Depressive Disorder / Q000175:diagnosis / Q000188:drug therapy* / Q000523:psychology; D061218:Depressive Disorder, Treatment-Resistant / Q000175:diagnosis / Q000188:drug therapy / Q000523:psychology; D004347:Drug Interactions; D018565:Food-Drug Interactions; D006801:Humans; D006974:Hypertension, Malignant / Q000139:chemically induced; D008996:Monoamine Oxidase Inhibitors / Q000008:administration & dosage / Q000009:adverse effects*; D018490:Serotonin Agents / Q000008:administration & dosage / Q000009:adverse effects; D020230:Serotonin Syndrome / Q000175:diagnosis / Q000209:etiology; D013566:Sympathomimetics / Q000008:administration & dosage / Q000009:adverse effects; D014439:Tyramine / Q000008:administration & dosage / Q000009:adverse effects
chemical_list: D000928:Antidepressive Agents; D008996:Monoamine Oxidase Inhibitors; D018490:Serotonin Agents; D013566:Sympathomimetics; D014439:Tyramine