title: Enantioselective organocatalytic domino synthesis of tetrahydropyridin-2-ols.
abstract: The asymmetric synthesis of tetrahydropyridin-2-ols from enals and enaminones is described. The organocatalytic domino reaction involves a Michael addition-hemiaminalization sequence using the Jørgensen-Hayashi catalyst. Dehydration or oxidation leads to the corresponding 1,4-dihydro-pyridines or 3,4-dihydropyridin-2-ones in a one-pot fashion.
authors.affiliation: Institute of Organic Chemistry, RWTH Aachen University, Landoltweg 1, 52074 Aachen, Germany.
authors.forename: Jie-Ping
authors.initials: JP
authors.lastname: Wan
authors.forename: Charles C J
authors.initials: CC
authors.lastname: Loh
authors.forename: Fangfang
authors.initials: F
authors.lastname: Pan
authors.forename: Dieter
authors.initials: D
authors.lastname: Enders