title: ANCA-associated diseases and lung carcinomas: a five-case series.
abstract: Microscopic polyangiitis, granulomatosis with polyangiitis, Churg-Strauss syndrome and focal necrotizing glomerulonephritis are severe systemic vasculitides associated with circulating antineutrophil cytoplasmic antibodies (ANCA). Several studies reported that some malignancies can develop in these patients during follow-up, but few studies have considered the association and role of pre-existing cancers, at least in a fraction of patients. Herein, we report five patients with ANCA-associated diseases who had associated lung carcinomas or were diagnosed within 2 years after vasculitis onset. We discuss the putative role of tumor antigen in driving the auto-immune response.
authors.forename: Jonathan Maurice
authors.initials: JM
authors.lastname: Chemouny
authors.forename: Christian
authors.initials: C
authors.lastname: Pagnoux
authors.forename: Valérie
authors.initials: V
authors.lastname: Caudwell
authors.forename: Alexandre
authors.initials: A
authors.lastname: Karras
authors.forename: Raphaël
authors.initials: R
authors.lastname: Borie
authors.forename: Loïc
authors.initials: L
authors.lastname: Guillevin
authors.forename: François
authors.initials: F
authors.lastname: Vrtovsnik
authors.forename: Eric
authors.initials: E
authors.lastname: Daugas
mesh_terms: D000230:Adenocarcinoma / Q000150:complications* / Q000175:diagnosis / Q000276:immunology / Q000601:surgery; D000077192:Adenocarcinoma of Lung; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D056648:Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis / Q000150:complications* / Q000175:diagnosis / Q000276:immunology / Q000628:therapy; D019268:Antibodies, Antineutrophil Cytoplasmic / Q000097:blood; D000951:Antigens, Neoplasm / Q000276:immunology; D015415:Biomarkers / Q000097:blood; D002294:Carcinoma, Squamous Cell / Q000150:complications* / Q000175:diagnosis / Q000276:immunology / Q000601:surgery; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D008175:Lung Neoplasms / Q000150:complications* / Q000175:diagnosis / Q000276:immunology / Q000601:surgery; D008297:Male; D009367:Neoplasm Staging; D010956:Plasmapheresis; D011013:Pneumonectomy; D012307:Risk Factors; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: D019268:Antibodies, Antineutrophil Cytoplasmic; D000951:Antigens, Neoplasm; D015415:Biomarkers; D007166:Immunosuppressive Agents