title: Restylane persisting in lower eyelids for 5 years.
abstract: The authors report the case of a 58-year-old woman presenting with "puffiness" in her lower eyelids persisting for approximately 5 years. While dark, puffy eyelid circles following hyaluronic acid placement periorbitally are not uncommon, what is so unusual in our case is that it was noted 5 years after treatment with Restylane. It has been our experience that hyaluronic acid within periorbital tissues can result in a negative cosmetic outcome that can persist for years after the treatment.
authors.forename: Steven H
authors.initials: SH
authors.lastname: Dayan
authors.forename: John P
authors.initials: JP
authors.lastname: Arkins
authors.forename: Michael
authors.initials: M
authors.lastname: Somenek
mesh_terms: D003357:Cosmetic Techniques / Q000009:adverse effects; D003879:Dermatologic Agents / Q000009:adverse effects*; D005143:Eyelids / Q000473:pathology*; D005260:Female; D006801:Humans; D006820:Hyaluronic Acid / Q000009:adverse effects / Q000031:analogs & derivatives*; D006821:Hyaluronoglucosaminidase / Q000627:therapeutic use*; D008875:Middle Aged
chemical_list: D003879:Dermatologic Agents; D006820:Hyaluronic Acid; D006821:Hyaluronoglucosaminidase; C445361:Restylane