title: The role of PARP-1 and PARP-2 enzymes in metabolic regulation and disease.
abstract: While originally described as DNA damage repair agents, recent data suggest a role for poly(ADP-ribose) polymerase (PARP) enzymes in metabolic regulation by influencing mitochondrial function and oxidative metabolism. Here we review how PARP activity has a major metabolic impact and the role of PARP-1 and PARP-2 in diverse metabolic complications.
authors.affiliation: Department of Medical Chemistry, University of Debrecen, Medical and Health Science Center, Debrecen 4032, Hungary. baip@med.unideb.hu
authors.forename: Péter
authors.initials: P
authors.lastname: Bai
authors.forename: Carles
authors.initials: C
authors.lastname: Cantó
mesh_terms: D004734:Energy Metabolism / Q000502:physiology*; D006801:Humans; D008659:Metabolic Diseases / Q000201:enzymology*; D053858:Metabolic Networks and Pathways / Q000502:physiology*; D008928:Mitochondria / Q000201:enzymology* / Q000378:metabolism; D000071137:Poly (ADP-Ribose) Polymerase-1; D011065:Poly(ADP-ribose) Polymerases / Q000378:metabolism*; D056564:Sirtuin 1 / Q000378:metabolism; D014157:Transcription Factors / Q000378:metabolism*
chemical_list: D014157:Transcription Factors; C499320:PARP1 protein, human; C483041:PARP2 protein, human; D000071137:Poly (ADP-Ribose) Polymerase-1; D011065:Poly(ADP-ribose) Polymerases; C447939:SIRT1 protein, human; D056564:Sirtuin 1