title: [Shengjing prescription improves semen parameters of oligoasthenozoospermia patients: efficacy and mechanism].
abstract: OBJECTIVE
  To investigate the clinical efficacy of Shengjing prescription for oligoasthenozoospermia and its action mechanism.
  
  
  METHODS
  We equally assigned 120 patients with oligoasthenozoospermia to receive Shengjing prescription (treatment group) and vitamin E (control group), respectively, for 12 weeks. Before and after the treatment, were obtained sperm concentration, sperm motility, the percentage of morphologically normal sperm, the levels of serum follicle-stimulating hormone (FSH), testosterone (T) and luteinizing hormone (LH), sperm DNA fragmentation index (DFI), the percentage of hypotonic swelling sperm, and the levels of seminal plasma elastase, x-glucosidase, fructose, zinc and acrosin.
  
  
  RESULTS
  Compared with vitamin E, Shengling prescription significantly improved sperm concentration, motility and morphology (P < 0.01), decreased the serum FSH level, elevated the serum T level (P <0. 01) , reduced DFI and seminal plasma elastase, and increased the percentage of hypotonic swelling sperm as well as the levels of seminal plasma cx-glucosidase, fructose, zinc and acrosin.
  
  
  CONCLUSIONS
  Shengjing prescription improves semen parameters of patients with oligoasthenozoospermia at multiple levels and through multiple channels.
authors.affiliation: Center of Reproduction and Heredity, The Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan, Shandong 250011, China.
authors.forename: Zhen-Gao
authors.initials: ZG
authors.lastname: Sun
authors.forename: Fang
authors.initials: F
authors.lastname: Lian
authors.forename: Kun-Peng
authors.initials: KP
authors.lastname: Jiang
authors.forename: Jian-Wei
authors.initials: JW
authors.lastname: Zhang
authors.forename: Feng-Mei
authors.initials: FM
authors.lastname: Ma
authors.forename: Ning
authors.initials: N
authors.lastname: Zhang
authors.forename: Jin-Long
authors.initials: JL
authors.lastname: Sun
authors.forename: Wu-Wen
authors.initials: WW
authors.lastname: Yang
mesh_terms: D000328:Adult; D053627:Asthenozoospermia / Q000188:drug therapy* / Q000503:physiopathology; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D006801:Humans; D007248:Infertility, Male; D008297:Male; D008517:Phytotherapy; D013076:Sperm Count; D013081:Sperm Motility; D016896:Treatment Outcome; D014810:Vitamin E / Q000627:therapeutic use
chemical_list: D004365:Drugs, Chinese Herbal; C532830:shengjing; D014810:Vitamin E