title: [Change of T lymphocyte subsets, interleukin-2 and tumor necrosis factor-alpha in tumor-bearing mice and patients with oral cancer receiving thermo-chemotherapy].
abstract: OBJECTIVE
  To investigate the change of T lymphocyte subsets, interleukin (IL)-2 and tumor necrosis factor (TNF)-alpha in the tumor- bearing mice and patients with oral cancer receiving thermo-chemotherapy, and investigate the correlation among them.
  
  
  METHODS
  After treatments, the expression of lymphocyte transformation index (LTI), IL-2 and TNF-alpha in the tumor-bearing mice were detected with methyl thiazolyl tetrazolium (MTT), the expression of IL-2 and TNF-alpha in the patients with oral cancer were detected with MTT, the expression of LTI, CD4+ and CD8+ were detected with 3H-TdR incorporation.
  
  
  RESULTS
  LTI, IL-2 and TNF-alpha of thermo-chemotherapy group (HP group) had no significant difference comparing with those of normal mice group (N group) (P>0.05), but which were significantly higher than those of chemotherapy group (P group) and no treatment group (NT group) (P<0.01). In clinical trials, the expression of LTI, CD4+, CD4+/CD8+, IL-2 and TNF-alpha on oral cancer patients after thermo-chemotherapy were significantly higher than those before thermo-chemotherapy (P<0.01).
  
  
  CONCLUSIONS
  After thermo-chemotherapy, the expression of LTI, IL-2 and TNF-alpha of tumor-bearing hosts are significantly improved, there is a significant correlation between IL-2 and T cell.
authors.affiliation: Dept. of Stomatology, People's Hospital of Fushan District of Yantai City, Yantai 265500, China.
authors.forename: Chunsheng
authors.initials: C
authors.lastname: Shi
authors.forename: Huijun
authors.initials: H
authors.lastname: Jin
authors.forename: Jan
authors.initials: J
authors.lastname: Zhao
authors.forename: Sheng-Zhi
authors.initials: SZ
authors.lastname: Wang
authors.forename: Zuyi
authors.initials: Z
authors.lastname: Mao
mesh_terms: D000818:Animals; D006801:Humans; D007376:Interleukin-2; D051379:Mice; D009062:Mouth Neoplasms; D009369:Neoplasms; D016176:T-Lymphocyte Subsets; D014409:Tumor Necrosis Factor-alpha
chemical_list: D007376:Interleukin-2; D014409:Tumor Necrosis Factor-alpha