title: Role of CaCO3 alone and CaCO3 plus vitamin D3 in terms of calcium phosphorus product in chronic kidney diseases.
abstract: BACKGROUND
  CaCO3 alone and CaCO3 plus vitamin D3 metabolites are commonly prescribed in CKD patients. The objective of this study is to analyze the changes in Ca x P product, calcium level and phosphorus level in CKD patients receiving calcium carbonate alone and calcium carbonate with vitamin D3 in combination.
  
  
  METHODS
  A prospective, cross sectional study among CKD patients under maintenance hemodialysis two times a week were studied over a period of one year. The patients were divided into two groups receiving oral CaCO3 alone and CaCO3 plus vitamin D3 once a day. The patients were followed for 1 month and result of Ca x P product was analyzed accordingly.
  
  
  RESULTS
  Mean decrease of Ca x P product in CaCO3 group is (50.42+/-8.85 to 47 +/-6.63) in one month, p value =0.001(0.6-5) and CI- 95%. There is also significant reduction of phosphorus level in CaCO3 group than CaCO3 plus vitamin D3 group. Mean decrease in phosphorus in CaCO3 group is (5.51+/-0.76 to 5.17+/- 0.05) in one month. P value =0.01(0.14-0.53) and CI 95%.
  
  
  CONCLUSIONS
  There is a significant decrease in Ca x P product and phosphorus level was observed in CKD patients taking CaCO3 alone.
authors.affiliation: Department of Medicine, Kathmandu Medical College Teaching Hospital, Sinamangal, Nepal. adhikarylaxu@gmail.com
authors.forename: L
authors.initials: L
authors.lastname: Adhikary
authors.forename: S
authors.initials: S
authors.lastname: Acharya
authors.forename: L
authors.initials: L
authors.lastname: Acharya
mesh_terms: D000328:Adult; D000863:Antacids / Q000627:therapeutic use*; D002118:Calcium / Q000378:metabolism*; D002119:Calcium Carbonate / Q000627:therapeutic use*; D002762:Cholecalciferol / Q000627:therapeutic use*; D003430:Cross-Sectional Studies; D004359:Drug Therapy, Combination / Q000379:methods; D005260:Female; D006801:Humans; D007676:Kidney Failure, Chronic / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D009390:Nepal; D010758:Phosphorus / Q000378:metabolism*; D011446:Prospective Studies; D006435:Renal Dialysis; D014815:Vitamins / Q000627:therapeutic use*
chemical_list: D000863:Antacids; D014815:Vitamins; D002762:Cholecalciferol; D010758:Phosphorus; D002119:Calcium Carbonate; D002118:Calcium