title: Cardiovascular magnetic resonance measurement of myocardial extracellular volume in health and disease.
abstract: OBJECTIVE
  To measure and assess the significance of myocardial extracellular volume (ECV), determined non-invasively by equilibrium contrast cardiovascular magnetic resonance, as a clinical biomarker in health and a number of cardiac diseases of varying pathophysiology.
  
  
  METHODS
  Prospective study.
  
  
  METHODS
  Tertiary referral cardiology centre in London, UK.
  
  
  METHODS
  192 patients were mainly recruited from specialist clinics. We studied patients with Anderson-Fabry disease (AFD, n=17), dilated cardiomyopathy (DCM, n=31), hypertrophic cardiomyopathy (HCM, n=31), severe aortic stenosis (AS, n=66), cardiac AL amyloidosis (n=27) and myocardial infarction (MI, n=20). The results were compared with those for 81 normal subjects.
  
  
  RESULTS
  In normal subjects, ECV (mean (95% CI), measured in the septum) was slightly higher in women than men (0.273 (0.264 to 0.282 vs 0.233 (0.225 to 0.244), p<0.001), with no change with age. In disease, the ECV of AFD was the same as in normal subjects but higher in all other diseases (p<0.001). Mean ECV was the same in DCM, HCM and AS (0.280, 0.291, 0.276 respectively), but higher in cardiac AL amyloidosis and higher again in MI (0.466 and 0.585 respectively, each p<0.001). Where ECV was elevated, correlations were found with indexed left ventricular mass, end systolic volume, ejection fraction and left atrial area in apparent disease-specific patterns.
  
  
  CONCLUSIONS
  Myocardial ECV, assessed non-invasively in the septum with equilibrium contrast cardiovascular magnetic resonance, shows gender differences in normal individuals and disease-specific variability. Therefore, ECV shows early potential to be a useful biomarker in health and disease.
authors.affiliation: The Heart Hospital, 16-18 Westmoreland St, London W1G 8PH, UK.
authors.forename: Daniel M
authors.initials: DM
authors.lastname: Sado
authors.forename: Andrew S
authors.initials: AS
authors.lastname: Flett
authors.forename: Sanjay M
authors.initials: SM
authors.lastname: Banypersad
authors.forename: Steven K
authors.initials: SK
authors.lastname: White
authors.forename: Viviana
authors.initials: V
authors.lastname: Maestrini
authors.forename: Giovanni
authors.initials: G
authors.lastname: Quarta
authors.forename: Robin H
authors.initials: RH
authors.lastname: Lachmann
authors.forename: Elaine
authors.initials: E
authors.lastname: Murphy
authors.forename: Atul
authors.initials: A
authors.lastname: Mehta
authors.forename: Derralynn A
authors.initials: DA
authors.lastname: Hughes
authors.forename: William J
authors.initials: WJ
authors.lastname: McKenna
authors.forename: Andrew M
authors.initials: AM
authors.lastname: Taylor
authors.forename: Derek J
authors.initials: DJ
authors.lastname: Hausenloy
authors.forename: Philip N
authors.initials: PN
authors.lastname: Hawkins
authors.forename: Perry M
authors.initials: PM
authors.lastname: Elliott
authors.forename: James C
authors.initials: JC
authors.lastname: Moon
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000704:Analysis of Variance; D003287:Contrast Media; D005260:Female; D006325:Heart Atria / Q000473:pathology; D006331:Heart Diseases / Q000175:diagnosis* / Q000473:pathology / Q000503:physiopathology; D006346:Heart Septum / Q000473:pathology; D006352:Heart Ventricles / Q000473:pathology / Q000503:physiopathology; D006801:Humans; D008131:London; D008279:Magnetic Resonance Imaging; D008297:Male; D008536:Meglumine; D008875:Middle Aged; D009206:Myocardium / Q000473:pathology*; D009942:Organometallic Compounds; D011237:Predictive Value of Tests; D011446:Prospective Studies; D012016:Reference Values; D012737:Sex Factors; D013318:Stroke Volume; D016277:Ventricular Function, Left; D055815:Young Adult
chemical_list: D003287:Contrast Media; D009942:Organometallic Compounds; D008536:Meglumine; C072417:gadoterate meglumine