title: Function and composition of male accessory gland secretions in Anopheles gambiae: a comparison with other insect vectors of infectious diseases.
abstract: Human malaria, a major public health burden in tropical and subtropical countries, is transmitted exclusively by the bite of a female Anopheles mosquito. Malaria control strategies aimed at inducing sexual sterility in natural vector populations are an attractive alternative  to the use of insecticides. However, despite their importance as disease vectors, limited information is available on the molecular mechanisms regulating fertility in Anopheles mosquitoes. In the major malaria vector, An. gambiae, the full complement of sperm and seminal fluid  required for a female's lifelong egg production is obtained from a single mating event. This single mating has important consequences for the physiology and behavior of An. gambiae females: in particular, they become refractory to further insemination, and they start laying eggs.  In other insects including Drosophila, similar post-copulatory changes are induced by seminal proteins secreted by the male accessory glands and transferred to the female during mating. In this review, we analyze the current state of knowledge on the function and characterization of  male seminal proteins in An. gambiae, and provide a comparative assessment of the role of these male reproductive factors in other mosquito vectors of human disease in which female post-copulatory behavior has been studied. Knowledge of the factors and mechanisms regulating fertility  in An. gambiae and other vectors can help the design of novel control strategies to fight the spread of disease.
authors.affiliation: University of Perugia, Italy.
authors.forename: Francesco
authors.initials: F
authors.lastname: Baldini
authors.forename: Paolo
authors.initials: P
authors.lastname: Gabrieli
authors.forename: David W
authors.initials: DW
authors.lastname: Rogers
authors.forename: Flaminia
authors.initials: F
authors.lastname: Catteruccia
mesh_terms: D000818:Animals; D000852:Anopheles / Q000737:chemistry* / Q000502:physiology*; D004702:Endocrine Glands / Q000737:chemistry / Q000502:physiology; D005260:Female; D005298:Fertility; D007301:Insect Hormones / Q000032:analysis*; D019476:Insect Proteins / Q000032:analysis*; D007303:Insect Vectors / Q000737:chemistry / Q000502:physiology; D008297:Male
chemical_list: D007301:Insect Hormones; D019476:Insect Proteins