title: Correlation of total polyphenolic content with antioxidant and antibacterial activity of 24 extracts from Greek domestic Lamiaceae species.
abstract: Lamiaceae family species are considered important because of their use in folk medicine, culinary and flavouring throughout the world. Their interesting bioactivities are attributed mainly to essential oils, polyphenols and terpenes. However, there are only few studies about polyphenolic extracts from Lamiaceae plants. Thus, 24 polyphenolic extracts from three Lamiaceae genera, Salvia, Mentha and Sideritis, collected in Greece were examined for antioxidant and antibacterial activity in correlation with their polyphenolic content. The results showed that the tested polyphenolic extracts had strong free radical scavenging activity against DPPH· and ABTS(+) radicals and protected from hydroxyl and peroxyl radical-induced DNA damage. Moreover, five extracts inhibited Staphylococcus aureus growth. Furthermore, the results showed that the total polyphenolic content is not correlated with the above activities, although this relation was different within each plant genus. This is the first study regarding the antioxidant and antibacterial activity of Salvia pomifera ssp. calycina, S. pomifera ssp. pomifera, Mentha microphylla and Sideritis raeseri ssp. attica species, and one of the few concerning protection from DNA damage and antibacterial activity of polyphenolic extracts from the rest of the tested species.
authors.affiliation: Department of Biochemistry and Biotechnology, University of Thessaly, Ploutonos 26 and Aiolou, Larissa 41221, Greece. stagkos@med.uth.gr
authors.forename: Dimitrios
authors.initials: D
authors.lastname: Stagos
authors.forename: Nikolaos
authors.initials: N
authors.lastname: Portesis
authors.forename: Chryssa
authors.initials: C
authors.lastname: Spanou
authors.forename: Dimitrios
authors.initials: D
authors.lastname: Mossialos
authors.forename: Nektarios
authors.initials: N
authors.lastname: Aligiannis
authors.forename: Eliza
authors.initials: E
authors.lastname: Chaita
authors.forename: Christos
authors.initials: C
authors.lastname: Panagoulis
authors.forename: Eleni
authors.initials: E
authors.lastname: Reri
authors.forename: Leandros
authors.initials: L
authors.lastname: Skaltsounis
authors.forename: Aristidis M
authors.initials: AM
authors.lastname: Tsatsakis
authors.forename: Dimitrios
authors.initials: D
authors.lastname: Kouretas
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000494:pharmacology*; D000975:Antioxidants / Q000032:analysis / Q000494:pharmacology*; D004249:DNA Damage / Q000187:drug effects; D016166:Free Radical Scavengers / Q000494:pharmacology; D006115:Greece; D019686:Lamiaceae / Q000737:chemistry*; D008826:Microbial Sensitivity Tests; D010936:Plant Extracts / Q000737:chemistry* / Q000494:pharmacology*; D010946:Plants, Medicinal / Q000737:chemistry; D059808:Polyphenols / Q000032:analysis*; D013211:Staphylococcus aureus / Q000187:drug effects
chemical_list: D000900:Anti-Bacterial Agents; D000975:Antioxidants; D016166:Free Radical Scavengers; D010936:Plant Extracts; D059808:Polyphenols