title: KI-catalyzed imidation of sp3 C-H bond adjacent to amide nitrogen atom.
abstract: We have developed a new KI-catalyzed method for the imidation of an sp(3) C-H bond adjacent to an amide nitrogen atom by using TBHP (tert-butyl hydroperoxide, 70% aqueous solution) as the oxidant. This novel procedure tolerated air and moisture and provided a series of novel products in moderate to excellent yields under mild conditions.
authors.affiliation: State Key Laboratory of Natural and Biomimetic Drugs, Department of Chemical Biology, School of Pharmaceutical Sciences, Peking University Health Science Center, Beijing 100191, PR China.
authors.forename: Zhi-Qi
authors.initials: ZQ
authors.lastname: Lao
authors.forename: Wen-He
authors.initials: WH
authors.lastname: Zhong
authors.forename: Qing-Hua
authors.initials: QH
authors.lastname: Lou
authors.forename: Zhong-Jun
authors.initials: ZJ
authors.lastname: Li
authors.forename: Xiang-Bao
authors.initials: XB
authors.lastname: Meng
mesh_terms: D000577:Amides / Q000737:chemistry*; D002384:Catalysis; D007094:Imides / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D011193:Potassium Iodide / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D000577:Amides; D007094:Imides; D011193:Potassium Iodide