title: The use of polymeric platinum(IV) prodrugs to deliver multinuclear platinum(II) drugs with reduced systemic toxicity and enhanced antitumor efficacy.
abstract: Two dinuclear platinum(IV) prodrugs were prepared from cisplatin and oxaliplatin, and tethered to amphiphilic biodegradable block copolymers. The polymeric dinuclear platinum(IV) prodrugs were allowed to self-assemble into nanomicelles, which showed reduced systemic toxicity, relatively long blood circulation, and enhanced antitumor efficacy. In this way, the bottleneck of present multinuclear platinum drugs, especially their severe systemic toxicity, might be overcome.
authors.affiliation: State Key Laboratory of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, 5625 Renmin Street, Changchun 130022, People's Republic of China.
authors.forename: Haihua
authors.initials: H
authors.lastname: Xiao
authors.forename: Haiqin
authors.initials: H
authors.lastname: Song
authors.forename: Yu
authors.initials: Y
authors.lastname: Zhang
authors.forename: Ruogu
authors.initials: R
authors.lastname: Qi
authors.forename: Rui
authors.initials: R
authors.lastname: Wang
authors.forename: Zhigang
authors.initials: Z
authors.lastname: Xie
authors.forename: Yubin
authors.initials: Y
authors.lastname: Huang
authors.forename: Yuxin
authors.initials: Y
authors.lastname: Li
authors.forename: Yin
authors.initials: Y
authors.lastname: Wu
authors.forename: Xiabin
authors.initials: X
authors.lastname: Jing
mesh_terms: D000818:Animals; D045744:Cell Line, Tumor; D002945:Cisplatin / Q000737:chemistry / Q000627:therapeutic use; D006801:Humans; D051379:Mice; D018613:Microscopy, Confocal; D049329:Nanostructures / Q000737:chemistry*; D009944:Organoplatinum Compounds / Q000737:chemistry / Q000627:therapeutic use; D000077150:Oxaliplatin; D010984:Platinum / Q000737:chemistry*; D011108:Polymers / Q000737:chemistry*; D011355:Prodrugs / Q000737:chemistry / Q000627:therapeutic use*; D023041:Xenograft Model Antitumor Assays
chemical_list: D009944:Organoplatinum Compounds; D011108:Polymers; D011355:Prodrugs; D000077150:Oxaliplatin; D010984:Platinum; D002945:Cisplatin