title: Stronger signal of recent selection for lactase persistence in Maasai than in Europeans.
abstract: Continued ability to digest lactose after weaning provides a possible selective advantage to individuals who have access to milk as a food source. The lactase persistence (LP) phenotype exists at varying frequencies in different populations and SNPs that modulate the regulation of the LCT gene have been identified in many of these populations. Very strong positive selection for LP has been illustrated for a single SNP (rs4988235) in northwestern European populations, which has become a textbook example of the effect of recent selective sweeps on genetic variation and linkage disequilibrium. In this study, we employed two different methods to detect signatures of positive selection in an East African pastoralist population in the HapMap collection, the Maasai from Kenya, and compared results with other HapMap populations. We found that signatures of recent selection coinciding with the LCT gene are the strongest across the genome in the Maasai population. Furthermore, the genome-wide signal of recent positive selection on haplotypic variation and population differentiation around the LCT gene is greater in the Maasai than in the CEU population (northwestern European descent), possibly due to stronger selection pressure, but it could also be an indication of more recent selection in Maasai compared with the Central European group or more efficient selection in the Maasai due to less genetic drift for their larger effective population size. This signal of recent selection is driven by a putative East African LP haplotype that is different from the haplotype that contributes to the LP phenotype in northwestern Europe.
authors.affiliation: Department of Evolutionary Biology, Evolutionary Biology Centre, Uppsala University, Uppsala, Sweden. cschlebu@gmail.com
authors.forename: Carina M
authors.initials: CM
authors.lastname: Schlebusch
authors.forename: Per
authors.initials: P
authors.lastname: Sjödin
authors.forename: Pontus
authors.initials: P
authors.lastname: Skoglund
authors.forename: Mattias
authors.initials: M
authors.lastname: Jakobsson
mesh_terms: D044383:Black People / Q000235:genetics*; D005006:Ethnicity / Q000235:genetics*; D018507:Gene Expression Regulation, Developmental / Q000235:genetics*; D006239:Haplotypes / Q000235:genetics; D006801:Humans; D007630:Kenya; D043322:Lactase / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide / Q000235:genetics; D012641:Selection, Genetic; D044465:White People / Q000235:genetics
chemical_list: D043322:Lactase