title: [Effect of dexmedetomidine on stress responses during extubation in patients undergoing uvulopalatopharyngoplasty].
abstract: OBJECTIVE
  To observe the effect of dexmedetomidine hydrochloride on stress responses during extubation in patients undergoing uvulopalatopharyngoplasty (UPPP).
  
  
  METHODS
  Eighty-six scheduled for UPPP under general anesthesia were randomly divided into dexmedetomidine group (group D, n = 50) and control group (group C, n = 36). All patients were transported into post anesthesia care unit (PACU) after surgery and maintained sedation and analgesia by infusing propofol and sufentanil. Patients in group D were administrated dexmedetomidine 0.5 µg/kg, group C were administrated equivalent volume of normal saline. Both groups were treated with mechanical ventilation 6 - 24 h before extubation. Recovery time, the dosage of sedative and analgesic drugs and side effects were recorded.
  
  
  RESULTS
  There were no significant differences between two groups in recovery time (P > 0.05). The dosage of propofol and sufentanil in group D were respectively (785 ± 65) mg, (176 ± 10) µg, significantly less than that in group C (950 ± 101) mg, (209 ± 14) µg (P < 0.05). side effects in group D were significantly less than that in group C (P < 0.01).
  
  
  CONCLUSIONS
  Dexmedetomidine hydrochloride could efficiently restrain the stress response around tracheal extubation, reduce postoperative complications in patients undergoing UPPP.
authors.affiliation: Department of Anesthesiology, Fourth Clinical College of Tianjin Medical University (Tianjin Fourth Central Hospital), Tianjin Nankai Hospital, China.
authors.forename: Bing-shu
authors.initials: BS
authors.lastname: Wang
authors.forename: Jian-bo
authors.initials: JB
authors.lastname: Yu
authors.forename: Fang
authors.initials: F
authors.lastname: Wang
authors.forename: Li
authors.initials: L
authors.lastname: Zhang
authors.forename: Yang
authors.initials: Y
authors.lastname: Zhang
authors.forename: Shi-qiang
authors.initials: SQ
authors.lastname: Li
mesh_terms: D000328:Adult; D000368:Aged; D060666:Airway Extubation; D000762:Anesthesia Recovery Period; D020927:Dexmedetomidine / Q000627:therapeutic use*; D004311:Double-Blind Method; D006801:Humans; D006993:Hypnotics and Sedatives / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D013517:Otorhinolaryngologic Surgical Procedures; D010609:Pharyngeal Muscles / Q000601:surgery; D011183:Postoperative Complications / Q000517:prevention & control*; D013312:Stress, Physiological / Q000187:drug effects*; D014609:Uvula / Q000601:surgery; D055815:Young Adult
chemical_list: D006993:Hypnotics and Sedatives; D020927:Dexmedetomidine