title: Excited-state dynamics of bis-dehydroxycurcumin carboxylic acid, a water-soluble derivative of the photosensitizer curcumin.
abstract: Bis-dehydroxycurcumin carboxylic acid (K2A23) is a synthetic curcuminoid designed to exhibit enhanced water solubility and photosensitizing potential with respect to natural curcumin. In this work, the tendency of the compound to form intra- and intermolecular hydrogen bonds in the ground state is studied by UV-visible absorption and by nuclear magnetic resonance (NMR). The excited-state dynamics of the drug are probed in different environments by means of time-correlated single-photon counting measurements and related to its hydrogen bonding affinity in the excited state.
authors.affiliation: Department of Science and High Technology, University of Insubria, Via Valleggio 11, 22100 Como, Italy. luca.nardo@uninsubria.it
authors.forename: Luca
authors.initials: L
authors.lastname: Nardo
authors.forename: Angelo
authors.initials: A
authors.lastname: Maspero
authors.forename: Marco
authors.initials: M
authors.lastname: Selva
authors.forename: Maria
authors.initials: M
authors.lastname: Bondani
authors.forename: Giovanni
authors.initials: G
authors.lastname: Palmisano
authors.forename: Erika
authors.initials: E
authors.lastname: Ferrari
authors.forename: Monica
authors.initials: M
authors.lastname: Saladini
mesh_terms: D002264:Carboxylic Acids / Q000737:chemistry*; D003474:Curcumin / Q000031:analogs & derivatives / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D017319:Photosensitizing Agents / Q000737:chemistry*; D013050:Spectrometry, Fluorescence; D013056:Spectrophotometry, Ultraviolet
chemical_list: D002264:Carboxylic Acids; D017319:Photosensitizing Agents; D003474:Curcumin