title: [Expression of PCNA and LNGFr in olfactory epithelium of patients suffering from dysosmia caused by chronic sinusitis].
abstract: OBJECTIVE
  To study the expression of PCNA and LNGFr in olfactory epithelium of patients suffering from dysosmia caused by chronic sinusitis, and the function of LNGFr.
  
  
  METHODS
  Forty-six patients undergoing FESS were chosen. Before operation, their olfactory functions were examined with CCCRC. According to their CCCRC scores, they were divided into three groups. Group A: Patients with chronic sinusitis and dysosmia 25 cases; Group B: Patients with chronic sinusitis and a normal olfactory function 10 cases; Group C: Patients with deviation of nasal septum and a normal olfactory function 11 cases. The expressions of PCNA and LNGFr were measured in olfactory mucosas of the three groups by immunohistochemistry.
  
  
  RESULTS
  In basal cells, the expression of PCNA and LNGFr in group A was higher than that in group B (P < 0.01). and in group C (P < 0.01). There was negative correlation between positive cells of PCNA and CCCRC score in basal cells of group A (r = -0.7441, P < 0.01); There was negative correlation between integral optical density of LNGFr and CCCRC score in basal cells of group A (r = -0.4407, P < 0.05). There was positive correlation between positive cells of PCNA and integral optical density of LNGFr in basal cells of group A (r = 0.5317, P < 0.01).
  
  
  CONCLUSIONS
  Basal cells proliferated dramatically in patients suffering from dysosmia caused by chronic sinusitis. The proliferating capacity of basal cells was related to up-regulation of LNGFr expression.
authors.affiliation: Department of Otolaryngology, Beijing Shunyi Hospital, Beijing, 101300, China.
authors.forename: Li
authors.initials: L
authors.lastname: Li
authors.forename: Yan
authors.initials: Y
authors.lastname: Zhang
authors.forename: Jianzhang
authors.initials: J
authors.lastname: Pu
authors.forename: Guifang
authors.initials: G
authors.lastname: Li
authors.forename: Ming
authors.initials: M
authors.lastname: Ye
mesh_terms: D002908:Chronic Disease; D006801:Humans; D007150:Immunohistochemistry; D009419:Nerve Tissue Proteins / Q000378:metabolism*; D000857:Olfaction Disorders / Q000378:metabolism*; D009831:Olfactory Mucosa / Q000378:metabolism*; D018809:Proliferating Cell Nuclear Antigen / Q000378:metabolism*; D017475:Receptors, Nerve Growth Factor / Q000378:metabolism*; D012852:Sinusitis / Q000150:complications*
chemical_list: C484065:NGFR protein, human; D009419:Nerve Tissue Proteins; D018809:Proliferating Cell Nuclear Antigen; D017475:Receptors, Nerve Growth Factor