title: Synthesis, crystal structure, characterisation, and antifungal activity of 3-thiophene aldehyde semicarbazone (3STCH), 2,3-thiophene dicarboxaldehyde bis(semicarbazone) (2,3BSTCH2) and their nickel (II) complexes.
abstract: The reaction of nickel (II) chloride and bromide with 3-thiophene aldehyde semicarbazone (3STCH) and 2,3-thiophene dicarboxaldehyde bis(semicarbazone) (2,3BSTCH(2)) leads to the formation of a series of new complexes: [NiCl(2)(3STCH)(2)], [NiBr(2)(3STCH)(2)], [NiCl(2,3BSTCH(2))(H(2)O)]Cl, and [NiBr(2,3BSTCH(2))(H(2)O)]Br respectively. The crystal structures of the two ligands 3STCH, 2,3BSTCH(2) and of the complex [NiBr(2,3BSTCH(2))(H(2)O)]Br have been determined by X-ray diffraction methods. For all these complexes, the central ion is coordinated through the oxygen atom of the carbonyle and the azomethine nitrogen atom of the semicarbazone. The antifungal activity of the complexes and their corresponding ligands was evaluated against some strains of respectively, Candida albicans, Candida glabrata and Aspergillus fumigatus. The complexes with 3STCH and 2,3BSTCH(2) revealed interesting CMI(80) values specifically against C. glabrata. Cytotoxicity assay was also carried out in vitro on MRC5 cells.
authors.affiliation: Laboratoire SONAS, EA 921, Université d'Angers, IFR QUASAV 149, UFR Sciences Pharmaceutiques et Ingénierie de la Santé, 16 Boulevard Daviers, F-49045 Angers cedex 01, France.
authors.forename: Kusaï
authors.initials: K
authors.lastname: Alomar
authors.forename: Vincent
authors.initials: V
authors.lastname: Gaumet
authors.forename: Magali
authors.initials: M
authors.lastname: Allain
authors.forename: Gilles
authors.initials: G
authors.lastname: Bouet
authors.forename: Anne
authors.initials: A
authors.lastname: Landreau
mesh_terms: D000935:Antifungal Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D001232:Aspergillus fumigatus / Q000254:growth & development*; D002175:Candida / Q000254:growth & development*; D018360:Crystallography, X-Ray; D015394:Molecular Structure; D009532:Nickel / Q000737:chemistry / Q000494:pharmacology; D009942:Organometallic Compounds / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D013882:Thiosemicarbazones / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology
chemical_list: D000935:Antifungal Agents; D009942:Organometallic Compounds; D013882:Thiosemicarbazones; D009532:Nickel