title: Induced pluripotent stem cells and their potential for basic and clinical sciences.
abstract: Induced pluripotent stem (iPS) cells, are a type of pluripotent stem cell derived from adult somatic cells. They have been reprogrammed through inducing genes and factors to be pluripotent. iPS cells are similar to embryonic stem (ES) cells in many aspects. This review summarizes the recent progresses in iPS cell reprogramming and iPS cell based therapy, and describe patient specific iPS cells as a disease model at length in the light of the literature. This review also analyzes and discusses the problems and considerations of iPS cell therapy in the clinical perspective for the treatment of disease.
authors.affiliation: Department of Medicine, University of Minnesota Medical School, Minneapolis, MN, USA. ylei@umn.edu
authors.forename: Lei
authors.initials: L
authors.lastname: Ye
authors.forename: Cory
authors.initials: C
authors.lastname: Swingen
authors.forename: Jianyi
authors.initials: J
authors.lastname: Zhang
mesh_terms: D000328:Adult; D065150:Cellular Reprogramming; D006801:Humans; D057026:Induced Pluripotent Stem Cells / Q000166:cytology / Q000502:physiology*; D033581:Stem Cell Transplantation