title: The effect of camphor and borneol on rat thymocyte viability and oxidative stress.
abstract: Camphor and borneol are wildly distributed in the essential oils of medicinal plants from various parts of the World. Our study has been carried out to evaluate the effect of these two bicyclic monoterpenes on rat thymocytes. Camphor and borneol at concentrations of 0.5 and 5 µg/mL did not induce significant toxicity on the immune system cells, while a significant increase of thymocyte viability was detected when cells were incubated with 50 µg/mL of camphor. A significant increase of cell viability was similarly detected when thymocytes were cultivated with borneol at concentrations of 0.5 and 5 µg/mL. The role of camphor and borneol in reactive oxygen species (ROS) production and mitochondrial membrane potential (MMP) disturbances in rat thymocytes as well as their potential mechanism(s) of action were also discussed.
authors.affiliation: Department of Chemistry, Faculty of Pharmacy, Medical University of Sofia, 2 Dunav Str., 1000 Sofia, Bulgaria. e.d.cherneva@gmail.com
authors.forename: Emiliya
authors.initials: E
authors.lastname: Cherneva
authors.forename: Voja
authors.initials: V
authors.lastname: Pavlovic
authors.forename: Andrija
authors.initials: A
authors.lastname: Smelcerovic
authors.forename: Denitsa
authors.initials: D
authors.lastname: Yancheva
mesh_terms: D000818:Animals; D001892:Camphanes / Q000494:pharmacology*; D002164:Camphor / Q000494:pharmacology*; D002470:Cell Survival / Q000187:drug effects; D002478:Cells, Cultured; D008297:Male; D053078:Membrane Potential, Mitochondrial / Q000187:drug effects*; D009822:Oils, Volatile / Q000737:chemistry / Q000494:pharmacology; D018384:Oxidative Stress / Q000187:drug effects*; D010938:Plant Oils / Q000737:chemistry / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D017382:Reactive Oxygen Species; D060168:Thymocytes / Q000187:drug effects* / Q000502:physiology*
chemical_list: D001892:Camphanes; D009822:Oils, Volatile; D010938:Plant Oils; D017382:Reactive Oxygen Species; D002164:Camphor; C022871:isoborneol