title: [Expression of transgelin-2 and clinical significance in colorectal cancer].
abstract: OBJECTIVE
  To investigate the relationship between the expression of transgelin-2 and the clinicopathological factors of colorectal carcinoma and evaluate the value of transgelin-2 in prognostic assessment of the colorectal cancer patients.
  
  
  METHODS
  Using tissue microarray and immunohistochemical methods, we examined transgelin-2 of 120 colorectal cancer patients received surgical treatment from September 2002 to April 2004, including 74 male and 46 female, age from 26 to 89 years. Analyzed the relationship between transgelin-2 and both the clinicopathological features and prognosis of the colorectal cancer by using χ² test and Kaplan-Meier survival analysis. Cox proportion hazard regression analysis was used to study the independent prognostic factors.
  
  
  RESULTS
  The positive rate of transgelin-2 expression was 69.2% in colorectal carcinoma. The transgelin-2 expression correlated with differentiation degree (χ² = 5.420), lymph nodes metastasis (χ² = 45.577), distant metastasis (χ² = 12.009), and TNM staging (χ² = 47.577). The survival time was (39 ± 5) months in patients with positive expression of the transgelin-2, while (59 ± 3) months in patients with negative expression. The patient's survival time was statistically correlated with the transgelin-2 expression (P = 0.003). Distant metastasis (RR = 8.318, 95%CI: 4.119 - 16.790), lymph nodes metastasis (RR = 2.794, 95%CI: 1.246 - 6.263) and transgelin-2 expression (RR = 1.834, 95%CI: 1.118- 2.973) were independent prognostic factors in patients with colorectal cancer (P < 0.05).
  
  
  CONCLUSIONS
  The expression of transgelin-2 is correlated with clinicopathological features and prognosis in colorectal cancer, may be the potential marker of metastasis and the prognosis of colorectal cancer patients.
authors.affiliation: Department of Gastrointestinal Surgery, Surgical Oncology Laboratory, Peking University People's Hospital, Beijing 100044, China.
authors.forename: Hong-qing
authors.initials: HQ
authors.lastname: Zhuo
authors.forename: Yan-bin
authors.initials: YB
authors.lastname: Zhang
authors.forename: Hui
authors.initials: H
authors.lastname: Zhang
authors.forename: Peng
authors.initials: P
authors.lastname: Guo
authors.forename: You
authors.initials: Y
authors.lastname: Lü
authors.forename: Ling-yi
authors.initials: LY
authors.lastname: Dong
authors.forename: Ke-wei
authors.initials: KW
authors.lastname: Jiang
authors.forename: Ying-jiang
authors.initials: YJ
authors.lastname: Ye
authors.forename: Shan
authors.initials: S
authors.lastname: Wang
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015179:Colorectal Neoplasms / Q000378:metabolism* / Q000473:pathology; D005260:Female; D006801:Humans; D053208:Kaplan-Meier Estimate; D008297:Male; D008840:Microfilament Proteins / Q000378:metabolism*; D008875:Middle Aged; D009124:Muscle Proteins / Q000378:metabolism*; D011379:Prognosis; D012044:Regression Analysis
chemical_list: D008840:Microfilament Proteins; D009124:Muscle Proteins; C051615:transgelin