title: Does protein phosphorylation govern host cell entry and egress by the Apicomplexa?
abstract: Members of the phylum Apicomplexa are responsible for a wide range of diseases in humans and animals. The absence of an effective vaccine or safe curing drugs and the continuous emergence of resistant parasites to available treatments impose a high demand on the identification of novel targets for intervention against the apicomplexans. Protein kinases are considered attractive potential therapeutic targets not only against cancers but also to combat infectious diseases. The scope and aim of this review is to report on the recent progress in dissecting the impact of protein phosphorylation in regulating motility and invasion.
authors.affiliation: Department of Microbiology and Molecular Medicine, Faculty of Medicine, CMU, 1 Rue Michel-Servet, 1211 Geneva, Switzerland. Damien.Jacot@unige.ch
authors.forename: Damien
authors.initials: D
authors.lastname: Jacot
authors.forename: Dominique
authors.initials: D
authors.lastname: Soldati-Favre
mesh_terms: D000199:Actins / Q000737:chemistry; D000818:Animals; D000953:Antigens, Protozoan / Q000737:chemistry; D016782:Apicomplexa / Q000737:chemistry* / Q000472:pathogenicity*; D001665:Binding Sites; D002118:Calcium / Q000737:chemistry; D020013:Calcium Signaling; D006790:Host-Parasite Interactions; D006801:Humans; D008565:Membrane Proteins / Q000737:chemistry; D010750:Phosphoproteins / Q000737:chemistry; D010766:Phosphorylation; D011494:Protein Kinases / Q000737:chemistry; D011528:Protozoan Infections / Q000469:parasitology*; D015800:Protozoan Proteins / Q000737:chemistry
chemical_list: C506564:AMA1 protein, Toxoplasma gondii; D000199:Actins; D000953:Antigens, Protozoan; D008565:Membrane Proteins; D010750:Phosphoproteins; D015800:Protozoan Proteins; D011494:Protein Kinases; C531238:calcium-dependent protein kinase-1, Plasmodium falciparum; D002118:Calcium