title: The lipid accumulation product is highly related to serum alanine aminotransferase level in male adults.
abstract: Studies confirm that the lipid accumulation product (LAP), which is based on the waist circumference and fasting serum triglycerides, is highly related to cardiovascular and metabolic diseases. Nonalcoholic fatty liver disease is a hepatic manifestation of metabolic syndrome and closely correlated with the alanine aminotransferase (ALT) elevation. Abdominal obesity and dyslipidemia are the important risk factors for nonalcoholic fatty liver disease. Our aim was to examine the correlation between the LAP and ALT in apparently healthy adults. We conducted a cross-sectional study of 587 adults. The blood pressure, anthropometric measurements, fasting and postload glucose, insulin, fasting lipid profile, and liver enzymes were measured. The LAP was calculated. For each gender, the subjects were divided into 3 groups according to the ALT level. The correlation between the LAP and ALT was analyzed. The LAP increased progressively across the ALT tertiles. A Pearson correlation analysis demonstrated that the LAP positively associated with the ALT in men and women (both P < .05) but independently related to the ALT only in men. Furthermore, after adjusting for the other confounding factors, the subjects in the upper quartile of LAP was 3.61 times more likely to show ALT elevation compared with those in the lower quartiles in men. In addition, in men, the LAP was considered as the best marker to predict increased ALT. Our findings suggested that the LAP was independently correlated with the ALT but only in men. The LAP was the main risk marker and might be superior to other variables in recognizing increased ALT.
authors.affiliation: Department of Endocrinology, the First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China.
authors.forename: Bao-Lan
authors.initials: BL
authors.lastname: Ji
authors.forename: Rong
authors.initials: R
authors.lastname: Li
authors.forename: Su-Hua
authors.initials: SH
authors.lastname: Zhang
authors.forename: Li-Lin
authors.initials: LL
authors.lastname: Gong
authors.forename: Zhi-Hong
authors.initials: ZH
authors.lastname: Wang
authors.forename: Wei
authors.initials: W
authors.lastname: Ren
authors.forename: Qi-Fu
authors.initials: QF
authors.lastname: Li
mesh_terms: D000328:Adult; D000410:Alanine Transaminase / Q000097:blood*; D003430:Cross-Sectional Studies; D050171:Dyslipidemias / Q000097:blood* / Q000150:complications; D005215:Fasting; D005234:Fatty Liver / Q000097:blood* / Q000209:etiology; D005260:Female; D006801:Humans; D050356:Lipid Metabolism; D008297:Male; D008875:Middle Aged; D065626:Non-alcoholic Fatty Liver Disease; D056128:Obesity, Abdominal / Q000097:blood* / Q000150:complications; D012737:Sex Factors; D014280:Triglycerides / Q000097:blood*; D055105:Waist Circumference
chemical_list: D014280:Triglycerides; D000410:Alanine Transaminase