title: Metal-free aerobic alcohol oxidation: intensification under three-phase flow conditions.
abstract: The selective oxidation of alcohols is a pivotal transformation within industrial and synthetic chemistry. In this contribution we use O₂ as terminal oxidant and (H)NO(x) species as oxygen shuttle in order to mediate the oxidation of primary and secondary alcohols under the influence of a solid acid catalyst. Process optimization and intensification through the use of a continuous three-phase flow reactor is demonstrated. Space-time yields were found to increase by two orders of magnitude with respect to batch experiments, along with additional gains in selectivity and a decrease of N₂O formation.
authors.affiliation: Institute for Chemical and Bioengineering, ETH Zurich, Switzerland.
authors.forename: Christof
authors.initials: C
authors.lastname: Aellig
authors.forename: David
authors.initials: D
authors.lastname: Scholz
authors.forename: Ive
authors.initials: I
authors.lastname: Hermans
mesh_terms: D000332:Aerobiosis; D000438:Alcohols / Q000737:chemistry*; D007700:Kinetics; D010084:Oxidation-Reduction; D013696:Temperature
chemical_list: D000438:Alcohols