title: Total synthesis of epiberberine.
abstract: Epiberberine, a natural bioactive protoberberine alkaloid, was totally synthesized in short, convenient and low-cost, four-step reactions including cyclization, condensation, reduction, and ring-closing, with an overall yield of 26.1%.
authors.affiliation: State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing, China.
authors.forename: Zi-Ming
authors.initials: ZM
authors.lastname: Lu
authors.forename: Jun-Qing
authors.initials: JQ
authors.lastname: Liang
authors.forename: Hong-Tao
authors.initials: HT
authors.lastname: Wang
authors.forename: Shao-Hua
authors.initials: SH
authors.lastname: Zhao
authors.forename: Hao
authors.initials: H
authors.lastname: Zhang
authors.forename: Peng-Fei
authors.initials: PF
authors.lastname: Tu
mesh_terms: D001599:Berberine / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry; D001600:Berberine Alkaloids / Q000138:chemical synthesis* / Q000737:chemistry; D002384:Catalysis; D003500:Cyclization; D015394:Molecular Structure
chemical_list: D001600:Berberine Alkaloids; D001599:Berberine; C009090:protoberberine; C061432:epiberberine