title: Effect of CpG ODN on monocytic myeloid derived suppressor cells.
abstract: CpG oligonucleotides stimulate via TLR9 and enhance anti-tumor immunity, an effect attributed to the activation of NK and CD8(+) T cells. Our recent work demonstrates that CpG ODN also induce monocytic myeloid-derived suppressor cells to mature into M1 macrophages, further aiding tumor elimination. This provides insight into the mechanism through which CpG promote tumor regression.
authors.affiliation: Cancer and Inflammation Program; National Cancer Institute; Frederick, MD USA ; Basic Science Program; SAIC-Frederick, Inc.; Frederick, MD USA.
authors.forename: Hidekazu
authors.initials: H
authors.lastname: Shirota
authors.forename: Dennis M
authors.initials: DM
authors.lastname: Klinman