title: Bacterial DNA translocation and liver disease severity among HIV-infected patients with chronic hepatitis C.
abstract: We carried out a cross-sectional study to explore whether bacterial 16S ribosomal DNA (bactDNA) shows association with severity of liver disease among human immunodeficiency virus/hepatitis C virus coinfected patients. Patients with advanced fibrosis (F3/F4), moderate activity grade (A2/A3), and high fibrosis progression rate (FPR > 0.15) had higher values of plasma bactDNA levels than did patients without these markers of liver disease (P < 0.05). The chance of having a fibrosis stage or activity grade increased was 1.20 [95% confidence interval (CI) = 1.0 to 1.44, P = 0.045] and 1.22 (95% CI = 1.1 to 1.45, P = 0.029) times greater for every 100 copies per microliter of plasma bactDNA. Likewise, the odds of having values of FPR > 0.15 was 1.18 (95% CI = 0.98 to 1.42, P = 0.089). In addition, patients with high bactDNA levels (≥175 copies per microliter) had the highest odds of having high values of Metavir score and FPR (P < 0.05). Our data show that bacterial translocation is associated with severe liver disease among human immunodeficiency virus-infected patients with chronic hepatitis C.
authors.affiliation: HIV and Hepatitis Coinfection Unit, National Centre of Microbiology, Instituto de Salud Carlos III, Majadahonda, Madrid, Spain.
authors.forename: Mónica
authors.initials: M
authors.lastname: García-Álvarez
authors.forename: Juan
authors.initials: J
authors.lastname: Berenguer
authors.forename: María
authors.initials: M
authors.lastname: Guzman-Fulgencio
authors.forename: Emilio
authors.initials: E
authors.lastname: Alvarez
authors.forename: Jaime
authors.initials: J
authors.lastname: Cosín
authors.forename: Dariela
authors.initials: D
authors.lastname: Micheloud
authors.forename: M Angeles
authors.initials: MA
authors.lastname: Jimenez-Sousa
authors.forename: Amanda
authors.initials: A
authors.lastname: Fernández-Rodríguez
authors.forename: Teresa
authors.initials: T
authors.lastname: Aldámiz-Echevarría
authors.forename: Ana
authors.initials: A
authors.lastname: Carrero
authors.forename: Pilar
authors.initials: P
authors.lastname: Miralles
authors.forename: Salvador
authors.initials: S
authors.lastname: Resino
mesh_terms: D000328:Adult; D001483:Base Sequence; D001693:Biological Transport, Active; D003430:Cross-Sectional Studies; D004269:DNA, Bacterial / Q000097:blood*; D018450:Disease Progression; D005260:Female; D015658:HIV Infections / Q000150:complications* / Q000382:microbiology*; D019698:Hepatitis C, Chronic / Q000150:complications* / Q000382:microbiology* / Q000473:pathology; D006801:Humans; D007413:Intestinal Mucosa / Q000382:microbiology; D008103:Liver Cirrhosis / Q000150:complications / Q000382:microbiology / Q000473:pathology; D008297:Male; D012336:RNA, Ribosomal, 16S / Q000097:blood
chemical_list: D004269:DNA, Bacterial; D012336:RNA, Ribosomal, 16S