title: Raman spectroscopic detection of sub-picomolar DNA by coupling silver catalyzed silver deposition with circular strand-replacement polymerization on magnetic nanoparticles.
abstract: A novel strategy of dual signal amplification was developed using circular strand-replacement DNA polymerization with a molecular beacon as a switch and silver enhancement on magnetic nanoparticles for the specific Raman spectroscopic detection of DNA down to the sub-picomolar level.
authors.affiliation: State Key Laboratory of Analytical Chemistry for Life Science, Department of Chemistry, Nanjing University, Nanjing 210093, PR China.
authors.forename: Fenglei
authors.initials: F
authors.lastname: Gao
authors.forename: Zhu
authors.initials: Z
authors.lastname: Zhu
authors.forename: Jianping
authors.initials: J
authors.lastname: Lei
authors.forename: Huangxian
authors.initials: H
authors.lastname: Ju
mesh_terms: D001565:Benzoates / Q000737:chemistry; D002384:Catalysis; D004247:DNA / Q000032:analysis*; D004259:DNA-Directed DNA Polymerase / Q000378:metabolism; D058185:Magnetite Nanoparticles / Q000737:chemistry*; D058105:Polymerization; D012834:Silver / Q000737:chemistry*; D013059:Spectrum Analysis, Raman; D013438:Sulfhydryl Compounds / Q000737:chemistry
chemical_list: D001565:Benzoates; D058185:Magnetite Nanoparticles; D013438:Sulfhydryl Compounds; C013594:4-mercaptobenzoate; D012834:Silver; D004247:DNA; D004259:DNA-Directed DNA Polymerase