title: [Studing the health status of workers occupationally exposed to carbon disulfide].
abstract: OBJECTIVE
  To study the effects of carbon disulfide (CS(2)) on the health of workers, and to provide the basis for the further preventive measures.
  
  
  METHODS
  The occupational health examination of 881 workers exposed to CS(2) in a chemical fiber factory was carried out according to the national technical standard of occupational health surveillance. The time weighted average concentrations (TWA) of CS(2) in the workshops of short silk and long silk exceeded the national standard, The workers in these two workshops served as the high exposure group. The workers of the other workshops were classified as low exposure group, in which TWA met the national standard. All exposed workers were also divided into long-term exposure group and short-term exposure group on the basis of average exposure years (16 years). The statistical analysis was used by t test, χ(2), and fisher exact test.
  
  
  RESULTS
  The symptom rates of numbness, fatigue, dizziness, insomnia and headache were 12.5%, 8.5%, 8.2%, 7.5%, and 7.2% respectively. The abnormal rates of superficial sensation, three fibrillation, achilles tendon reflex, patellar reflex, EMG, hypertension, triglycerides, low-density lipoprotein, and apolipoprotein B were 33.0%, 26.1%, 20.8%, 18.6%, 10.8%, 33.4%, 24.5%, 17.0% and 9.3% respectively. Among the high exposure group, the abnormal detectable rates of dizziness, headache, fatigue, insomnia, numbness, achilles tendon reflex, superficial and deep sensation, EMG, hypertension, ECG, total cholesterol, triglyceride and low density lipoprotein in long-term exposure group were significantly higher than those in short-term exposure group (P < 0.05 or P < 0.01). However, among the low exposure group, the abnormal rates of the insomnia achilles tendon reflex and superficial sensation in long term exposure group were significantly higher than those of short term exposure group (P < 0.05 or P < 0.01). The detected rates of hypertension, triglycerides, low-density lipoprotein, creatinine and uric acid were in males significantly greater than those in females (P < 0.05 or P < 0.01).
  
  
  CONCLUSIONS
  Long-term exposure to high concentrations of CS(2) could lead to the damage of nervous system, elevate blood pressure and promote the development and progression of hyperlipemia and atherosclerosis. Furthermore, CS(2) had greater effects on blood pressure and lipid in males than in females.
authors.affiliation: Occupational Disease Prevention Hospital in Nanjing, Nanjing 210042, China.
authors.forename: Hai-yan
authors.initials: HY
authors.lastname: Song
authors.forename: Chun-long
authors.initials: CL
authors.lastname: Wei
authors.forename: Qiu
authors.initials: Q
authors.lastname: Dong
authors.forename: Mei-lin
authors.initials: ML
authors.lastname: Wang
authors.forename: Chun-ping
authors.initials: CP
authors.lastname: Ji
authors.forename: Zhi-guo
authors.initials: ZG
authors.lastname: Hou
authors.forename: Xiao-min
authors.initials: XM
authors.lastname: Lu
authors.forename: Jin
authors.initials: J
authors.lastname: Xu
authors.forename: Shou-yu
authors.initials: SY
authors.lastname: Wang
authors.forename: Bao-li
authors.initials: BL
authors.lastname: Zhu
authors.forename: Chun-hui
authors.initials: CH
authors.lastname: Ni
mesh_terms: D000328:Adult; D002246:Carbon Disulfide / Q000009:adverse effects*; D002319:Cardiovascular System; D002617:Chemical Industry; D005260:Female; D006304:Health Status; D006801:Humans; D008297:Male; D008875:Middle Aged; D009098:Multiphasic Screening; D009422:Nervous System Diseases / Q000453:epidemiology; D016273:Occupational Exposure; D055815:Young Adult
chemical_list: D002246:Carbon Disulfide