title: Adhesion of osteoblasts to a vertically aligned TiO2 nanotube surface.
abstract: The adhesion of cells to vertically aligned TiO2 nanotubes is reviewed. The attraction between a negatively charged nanotube surface and a negatively charged osteoblast is facilitated by charged protein-mediators like proteins with a quadrupolar internal charge distribution, fibronectin and vitronectin. It is shown that adhesion and spreading of osteoblasts on vertically aligned TiO2 nanotube surfaces depend on the diameter of the nanotubes. Apparently, a small diameter nanotube surface has on average more sharp convex edges per unit area than a large one, leading to stronger binding affinity on its surface.
authors.affiliation: Laboratory of Biophysics, Faculty of Electrical Engineering, University of Ljubljana, Trzaska 25, SI-1000 Ljubljana, Slovenia.
authors.forename: Ekaterina
authors.initials: E
authors.lastname: Gongadze
authors.forename: Doron
authors.initials: D
authors.lastname: Kabaso
authors.forename: Sebastian
authors.initials: S
authors.lastname: Bauer
authors.forename: Jung
authors.initials: J
authors.lastname: Park
authors.forename: Patrik
authors.initials: P
authors.lastname: Schmuki
authors.forename: Aleš
authors.initials: A
authors.lastname: Iglič
mesh_terms: D000818:Animals; D002448:Cell Adhesion; D003198:Computer Simulation; D006801:Humans; D008954:Models, Biological; D043942:Nanotubes / Q000737:chemistry* / Q000648:ultrastructure; D010006:Osteoblasts / Q000166:cytology*; D013499:Surface Properties; D014025:Titanium / Q000737:chemistry*
chemical_list: D014025:Titanium