title: Nano-technology for targeted drug delivery to combat antibiotic resistance.
abstract: Several microbes have evolved clinically significant resistance against almost every available antibiotic. Yet the development of new classes of antibiotics has lagged far behind our growing need. Frequent and suboptimal use of antibiotics particularly in developing countries aggravated the problem by increasing the rate of resistance. Therefore, developing new and multidimensional strategies to combat microbial infections is warranted. These include i) modification of existing antibiotics, ii) searching new and novel antibiotics, iii) development and improvement of antibiotics carrier system to reduce amount and frequency of antibiotic doses, iv) development of targeted antibiotic delivery systems. Here, the authors discuss trends and development of nano-materials and alternative antimicrobials to solve the problem of antibiotic resistance.
authors.forename: Abhinay
authors.initials: A
authors.lastname: Sharma
authors.forename: Deepak
authors.initials: D
authors.lastname: Kumar Arya
authors.forename: Meenakshi
authors.initials: M
authors.lastname: Dua
authors.forename: Gursharan Singh
authors.initials: GS
authors.lastname: Chhatwal
authors.forename: Atul Kumar
authors.initials: AK
authors.lastname: Johri
mesh_terms: D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D003906:Developing Countries; D016503:Drug Delivery Systems; D004352:Drug Resistance, Microbial; D006801:Humans; D036103:Nanotechnology
chemical_list: D000900:Anti-Bacterial Agents