title: A degradable, bioactive, gelatinized alginate hydrogel to improve stem cell/growth factor delivery and facilitate healing after myocardial infarction.
abstract: Despite remarkable effectiveness of reperfusion and drug therapies to reduce morbidity and mortality following myocardial infarction (MI), many patients have debilitating symptoms and impaired left ventricular (LV) function highlighting the need for improved post-MI therapies. A promising concept currently under investigation is intramyocardial injection of high-water content, polymeric biomaterial gels (e.g., hydrogels) to modulate myocardial scar formation and LV adverse remodeling. We propose a degradable, bioactive hydrogel that forms a unique microstructure of continuous, parallel capillary-like channels (Capgel). We hypothesize that the innovative architecture and composition of Capgel can serve as a platform for endogenous cell recruitment and drug/cell delivery, therefore facilitating myocardial repair after MI.
authors.affiliation: Division of Cardiovascular Medicine, University of Florida, Gainesville, FL, USA.
authors.forename: Domenico G
authors.initials: DG
authors.lastname: Della Rocca
authors.forename: Bradley J
authors.initials: BJ
authors.lastname: Willenberg
authors.forename: Leonardo F
authors.initials: LF
authors.lastname: Ferreira
authors.forename: Prateek S
authors.initials: PS
authors.lastname: Wate
authors.forename: John W
authors.initials: JW
authors.lastname: Petersen
authors.forename: Eileen M
authors.initials: EM
authors.lastname: Handberg
authors.forename: Tong
authors.initials: T
authors.lastname: Zheng
authors.forename: Dennis A
authors.initials: DA
authors.lastname: Steindler
authors.forename: Naohiro
authors.initials: N
authors.lastname: Terada
authors.forename: Christopher D
authors.initials: CD
authors.lastname: Batich
authors.forename: Barry J
authors.initials: BJ
authors.lastname: Byrne
authors.forename: Carl J
authors.initials: CJ
authors.lastname: Pepine
mesh_terms: D000464:Alginates / Q000737:chemistry*; D006801:Humans; D020100:Hydrogels; D008855:Microscopy, Electron, Scanning; D009203:Myocardial Infarction / Q000628:therapy*; D019089:Stem Cell Factor / Q000008:administration & dosage*; D033581:Stem Cell Transplantation
chemical_list: D000464:Alginates; D020100:Hydrogels; D019089:Stem Cell Factor