title: Highly sensitive and selective dopamine biosensor based on 3,4,9,10-perylene tetracarboxylic acid functionalized graphene sheets/multi-wall carbon nanotubes/ionic liquid composite film modified electrode.
abstract: A sensitive and selective electrochemical sensor for determination of dopamine (DA) was fabricated based on 3,4,9,10-perylene tetracarboxylic acid functionalized graphene sheets, multi-wall carbon nanotubes and ionic liquid modified glass carbon electrode and the properties of modified electrode were characterized by scanning electron microscopy, transmission electron microscope and electrochemical impedance spectroscopy. The modified electrode showed excellent electrocatalytic activity toward the oxidation of DA. Meanwhile, a possible reaction mechanism related to the oxidation of DA was proposed. The differential pulse voltammetry was used for the determination of DA in the presence of 500 μM ascorbic acid and 330 μM uric acid under the optimum conditions and a good linear relationship between peak current and the concentration of DA was obtained in the concentration range from 0.03 μM to 3.82 mM with a detection limit of 1.2×10(-9) M (S/N=3). Moreover, the proposed method was successfully applied to determine DA in real sample and satisfactory results were obtained. The results showed that the modified electrode exhibits an excellent catalytic activity, good sensitivity, reproducibility and long-term stability.
authors.affiliation: College of Chemistry and Chemical Engineering, Key Lab of Bioelectrochemistry and Environmental Analysis of Gansu Province, Northwest Normal University, Lanzhou 730070, PR China.
authors.forename: Xiuli
authors.initials: X
authors.lastname: Niu
authors.forename: Wu
authors.initials: W
authors.lastname: Yang
authors.forename: Hao
authors.initials: H
authors.lastname: Guo
authors.forename: Jie
authors.initials: J
authors.lastname: Ren
authors.forename: Jinzhang
authors.initials: J
authors.lastname: Gao
mesh_terms: D015374:Biosensing Techniques / Q000295:instrumentation*; D003217:Conductometry / Q000295:instrumentation*; D004298:Dopamine / Q000032:analysis* / Q000737:chemistry; D004566:Electrodes; D004867:Equipment Design; D019544:Equipment Failure Analysis; D006108:Graphite / Q000737:chemistry*; D052578:Ionic Liquids / Q000737:chemistry; D037742:Nanotubes, Carbon / Q000737:chemistry*; D010569:Perylene / Q000031:analogs & derivatives* / Q000737:chemistry; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity
chemical_list: C560550:3,4,9,10-perylene tetracarboxylic acid; D052578:Ionic Liquids; D037742:Nanotubes, Carbon; D010569:Perylene; D006108:Graphite; D004298:Dopamine