title: [Laboratory rat selection for the trait "the absence of audiogenic seizure proneness"].
abstract: The hybrids between Krushinsky-Molodkina (KM) inbred strain, selected for high predisposition to audiogenic epilepsy (AE), and Wistar rats non-prone to audiogenic seizure were the initial population for selection. Rats were selected for the trait "the absence of audiogenic seizure proneness". The creation of such strain in which the significant proportion of animals develop no AE in response to sound and share partly the genetic background of the KM strain is very important for the correct use of RV strain as the laboratory model of seizure states. As alleles which determine the AE proneness are recessive the selection for the "opposite" trait proceeds necessarily slow.
authors.forename: I B
authors.initials: IB
authors.lastname: Fedotova
authors.forename: Z A
authors.initials: ZA
authors.lastname: Kostyna
authors.forename: N M
authors.initials: NM
authors.lastname: Surina
authors.forename: I I
authors.initials: II
authors.lastname: Poletaeva
mesh_terms: D000161:Acoustic Stimulation; D000483:Alleles; D000818:Animals; D003433:Crosses, Genetic; D020195:Epilepsy, Reflex / Q000235:genetics*; D020022:Genetic Predisposition to Disease; D010641:Phenotype; D051381:Rats; D017208:Rats, Wistar; D012640:Seizures / Q000235:genetics*; D012641:Selection, Genetic