title: Epigenetic changes associated with oocyte aging.
abstract: It is well established that the decline in female reproductive outcomes is related to postovulatory aging of oocytes and advanced maternal age. Poor oocyte quality is correlated with compromised genetic integrity and epigenetic changes during the oocyte aging process. Here, we review the epigenetic alterations, mainly focused on DNA methylation, histone acetylation and methylation associated with postovulatory oocyte aging as well as advanced maternal age. Furthermore, we address the underlying epigenetic mechanisms that contribute to the decline in oocyte quality during oocyte aging.
authors.affiliation: State Key Laboratory of Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, 100101, China.
authors.forename: XingWei
authors.initials: X
authors.lastname: Liang
authors.forename: JunYu
authors.initials: J
authors.lastname: Ma
authors.forename: Heide
authors.initials: H
authors.lastname: Schatten
authors.forename: QingYuan
authors.initials: Q
authors.lastname: Sun
mesh_terms: D000107:Acetylation; D000375:Aging / Q000235:genetics* / Q000378:metabolism / Q000473:pathology*; D000818:Animals; D019175:DNA Methylation; D044127:Epigenesis, Genetic; D005260:Female; D006657:Histones / Q000378:metabolism; D006801:Humans; D008423:Maternal Age; D008745:Methylation; D009865:Oocytes / Q000378:metabolism* / Q000473:pathology*
chemical_list: D006657:Histones