title: Hair zinc and selenium levels in children with recurrent wheezing.
abstract: The prevalence of asthma and other allergic diseases has increased markedly in the last few decades. Oxidative stress plays a central role in asthma pathogenesis, and reduced daily consumption of antioxidants is positively correlated with increased risk of asthma. Zinc (Zn) and selenium (Se) are the main antioxidant elements. In our study, we aimed to investigate hair Zn and Se levels in children with recurrent wheezing. The study included 65 patients with recurrent wheezing (RW) and 65 healthy children (HC). The hair Zn and Se levels (µg/g) of the RW group were lower in comparison with the HC group (162.43 ± 91.52 vs. 236.38 ± 126.44, P < 0.001, and 217.37 ± 83.01 vs. 280.53 ± 122.73, P < 0.001, respectively). Total antioxidant capacity (TAC) (mmol/L) of the RW group was found to be significantly lower in comparison with the HC group (1.38 ± 0.14 vs. 1.53 ± 0.20, respectively; P < 0.001). Number of wheezing episodes in the last 6 months were negatively correlated with serum TAC, hair Zn, and Se levels in RW group (r(p)  = -0.291, P = 0.001; r(p)  = -0.209, P = 0.017; r(p)  = -0.206, P = 0.019, respectively). The number of acute respiratory tract infection (ARTI) episodes in the last 6 months was negatively correlated with serum TAC and hair Zn levels (r(p)  = -0.316, P < 0.001, and r(p)  = -0.196, P = 0.025, respectively). In this study, we found that TAC, hair Zn, and hair Se levels were lower in children with RW than HC and negatively correlated with wheezing episodes in the last 6 months. Also body Zn and Se levels can be reliably measured in hair samples.
authors.affiliation: Department of Pediatric Allergy, Kecioren Teaching and Research Hospital, Ankara, Turkey.
authors.forename: Cem Hasan
authors.initials: CH
authors.lastname: Razi
authors.forename: Ahmet Zulfikar
authors.initials: AZ
authors.lastname: Akelma
authors.forename: Okhan
authors.initials: O
authors.lastname: Akin
authors.forename: Mesut
authors.initials: M
authors.lastname: Kocak
authors.forename: Osman
authors.initials: O
authors.lastname: Ozdemir
authors.forename: Aydin
authors.initials: A
authors.lastname: Celik
authors.forename: Fatih Mehmet
authors.initials: FM
authors.lastname: Kislal
mesh_terms: D000975:Antioxidants / Q000378:metabolism*; D001249:Asthma / Q000378:metabolism*; D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D004032:Diet; D005260:Female; D006197:Hair / Q000737:chemistry*; D006801:Humans; D007223:Infant; D008297:Male; D018384:Oxidative Stress; D012135:Respiratory Sounds; D012643:Selenium / Q000378:metabolism*; D015032:Zinc / Q000378:metabolism*
chemical_list: D000975:Antioxidants; D012643:Selenium; D015032:Zinc