title: Muscle biopsy findings predictive of malignancy in rare infiltrative dermatomyositis.
abstract: OBJECTIVE
  The characteristic pathological muscular findings of polymyositis (PM) and dermatomyositis (DM) have been shown to reflect their different pathogeneses. Here, we characterized the muscle biopsy findings of PM and DM patients with or without malignancy.
  
  
  METHODS
  We evaluated the muscle biopsy findings of 215 consecutive PM and DM patients admitted to our hospital between 1970 and 2009. Pathology of the lesion biopsy sections was classified into 3 types: endomysial infiltration-type, perivascular infiltration-type, and rare-infiltrative-type.
  
  
  RESULTS
  There was no difference between the muscle pathology of PM patients with and without malignancy. However, the incidence of rare-infiltrative type muscle pathology in DM patients with malignancy was significantly higher than in those without such tumors (p=0.0345).
  
  
  CONCLUSIONS
  The incidence of rare-infiltrative type muscle pathology may be a predictive marker of DM with malignancy.
authors.affiliation: Department of Neurology, Faculty of Life Sciences, Kumamoto University, 1-1-1 Honjo, Kumamoto 860-0811, Japan. uchino@jonan-hospital.or.jp
authors.forename: Makoto
authors.initials: M
authors.lastname: Uchino
authors.forename: Satoshi
authors.initials: S
authors.lastname: Yamashita
authors.forename: Katsuhisa
authors.initials: K
authors.lastname: Uchino
authors.forename: Akira
authors.initials: A
authors.lastname: Mori
authors.forename: Akio
authors.initials: A
authors.lastname: Hara
authors.forename: Tomohiro
authors.initials: T
authors.lastname: Suga
authors.forename: Tomoo
authors.initials: T
authors.lastname: Hirahara
authors.forename: Tatsuya
authors.initials: T
authors.lastname: Koide
authors.forename: En
authors.initials: E
authors.lastname: Kimura
authors.forename: Taro
authors.initials: T
authors.lastname: Yamashita
authors.forename: Akihiko
authors.initials: A
authors.lastname: Ueda
authors.forename: Ryoichi
authors.initials: R
authors.lastname: Kurisaki
authors.forename: Junko
authors.initials: J
authors.lastname: Suzuki
authors.forename: Shoji
authors.initials: S
authors.lastname: Honda
authors.forename: Yasushi
authors.initials: Y
authors.lastname: Maeda
authors.forename: Teruyuki
authors.initials: T
authors.lastname: Hirano
authors.forename: Yukio
authors.initials: Y
authors.lastname: Ando
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001706:Biopsy / Q000379:methods*; D003882:Dermatomyositis / Q000175:diagnosis* / Q000453:epidemiology / Q000473:pathology*; D005260:Female; D005805:Genes, MHC Class I / Q000235:genetics; D006801:Humans; D007150:Immunohistochemistry; D016177:Macrophage-1 Antigen / Q000235:genetics; D008297:Male; D008875:Middle Aged; D018908:Muscle Weakness / Q000209:etiology / Q000473:pathology; D018482:Muscle, Skeletal / Q000473:pathology*; D009369:Neoplasms / Q000453:epidemiology / Q000209:etiology; D010257:Paraneoplastic Syndromes / Q000175:diagnosis* / Q000453:epidemiology / Q000473:pathology*; D011237:Predictive Value of Tests; D055815:Young Adult
chemical_list: D016177:Macrophage-1 Antigen