title: Rheological properties of suspensions containing cross-linked starch nanoparticles prepared by spray and vacuum freeze drying methods.
abstract: The rheological behavior of suspensions containing vacuum freeze dried and spray dried starch nanoparticles was investigated to explore the effect of these two drying methods in producing starch nanoparticles which were synthesized using high pressure homogenization and mini-emulsion cross-linking technique. Suspensions containing 10% (w/w) spray dried and vacuum freeze dried nanoparticles were prepared. The continuous shear viscosity tests, temperature sweep tests, the frequency sweep and creep-recovery tests were carried out, respectively. The suspensions containing vacuum freeze dried nanoparticles showed higher apparent viscosity within shear rate range (0.1-100 s(-1)) and temperature range (25-90 °C). The suspensions containing vacuum freeze dried nanoparticles were found to have more shear thinning and less thixotropic behavior compared to those containing spray dried nanoparticles. In addition, the suspensions containing vacuum freeze dried particles had stronger elastic structure. However, the suspensions containing spray dried nanoparticles had more stiffness and greater tendency to recover from the deformation.
authors.affiliation: College of Engineering, China Agricultural University, P.O. Box 50, 17 Qinghua Donglu, Beijing 100083, China.
authors.forename: Ai-min
authors.initials: AM
authors.lastname: Shi
authors.forename: Dong
authors.initials: D
authors.lastname: Li
authors.forename: Li-jun
authors.initials: LJ
authors.lastname: Wang
authors.forename: Benu
authors.initials: B
authors.lastname: Adhikari
mesh_terms: D003432:Cross-Linking Reagents / Q000494:pharmacology*; D004337:Drug Carriers; D004355:Drug Stability; D005612:Freeze Drying; D053758:Nanoparticles / Q000737:chemistry*; D012212:Rheology; D013213:Starch / Q000737:chemistry*; D013535:Suspensions; D014618:Vacuum; D014783:Viscosity
chemical_list: D003432:Cross-Linking Reagents; D004337:Drug Carriers; D013535:Suspensions; D013213:Starch