title: Immunologic therapeutic interventions in asthma: impact on natural history.
abstract: The discovery of new pathobiological pathways involved in asthma chronicity and reliefs offers novel therapeutic avenues. Enhanced phenotyping criteria associated with simple biologic characterization allowed to test targeted interventions in selected patients. Long-term studies are de facto lacking but required to address their impact on the natural history of the disease. Here, the authors review all potential available therapeutics based on immunologic pathways involved in asthma pathophysiology during the last decade.
authors.affiliation: Department of Respiratory Disease, Hôpital Arnaud de Villeneuve, CHU Montpellier, Montpellier, France. a-bourdin@chu-montpellier.fr
authors.forename: Arnaud
authors.initials: A
authors.lastname: Bourdin
authors.forename: Marc
authors.initials: M
authors.lastname: Humbert
authors.forename: Pascal
authors.initials: P
authors.lastname: Chanez
mesh_terms: D001249:Asthma / Q000188:drug therapy* / Q000276:immunology / Q000503:physiopathology; D006801:Humans; D007155:Immunologic Factors / Q000627:therapeutic use*; D007249:Inflammation; D058990:Molecular Targeted Therapy; D010641:Phenotype; D016032:Randomized Controlled Trials as Topic; D012720:Severity of Illness Index; D015398:Signal Transduction; D016896:Treatment Outcome
chemical_list: D007155:Immunologic Factors