title: Microbial transformation of Norkurarinone by Cunninghamella blakesleana AS 3.970.
abstract: In this paper, microbial transformation of norkurarinone (1) by Cunninghamella blakesleana AS 3.970 was investigated and seven transformed products were isolated and characterized as kurarinone (2), 4″,5″-dihydroxykurarinone (3), 6″-hydroxyl-2'-methoxyl-norkurarinone 7-O-β-d-glucoside (4), 6″-hydroxyl-norkurarinone 4'-O-β-d-glucoside (5), 4″,5″-dihydroxynorkurarinone (6), 7-methoxyl-norkurarinone (7), and 7-methoxyl-4″,5″-dihydroxynorkurarinone (8), respectively. Among them, 3-5 are new compounds, and the glycosylation reaction in microbial transformation process was reported rarely. In addition, the cytotoxicities of transformed products (1-8) were also investigated.
authors.affiliation: State Key Laboratory of Chemical Resource Engineering, College of Life Science and Technology, Beijing University of Chemical Technology, Beijing, China.
authors.forename: Yan-Qiu
authors.initials: YQ
authors.lastname: Shi
authors.forename: Xiu-Lan
authors.initials: XL
authors.lastname: Xin
authors.forename: Hu-Cheng
authors.initials: HC
authors.lastname: Zhang
authors.forename: Bao-Jing
authors.initials: BJ
authors.lastname: Zhang
authors.forename: Chang-Yuan
authors.initials: CY
authors.lastname: Wang
authors.forename: Jie
authors.initials: J
authors.lastname: Hou
authors.forename: Qi-Peng
authors.initials: QP
authors.lastname: Yuan
authors.forename: Sa
authors.initials: S
authors.lastname: Deng
authors.forename: Yan
authors.initials: Y
authors.lastname: Tian
authors.forename: Xiao-Chi
authors.initials: XC
authors.lastname: Ma
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D020093:Cunninghamella / Q000378:metabolism*; D004354:Drug Screening Assays, Antitumor; D005419:Flavonoids / Q000737:chemistry / Q000302:isolation & purification / Q000378:metabolism*; D005960:Glucosides / Q000737:chemistry; D006031:Glycosylation; D006367:HeLa Cells; D006801:Humans; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D005419:Flavonoids; D005960:Glucosides; C411319:kurarinone