title: Supplementary ultrafiltration may improve inflammation and cardiac dysfunction in patients with high interdialytic weight gain.
abstract: OBJECTIVE
  We tested the hypothesis that adding an ultrafiltration session per week may improve brain natriuretic peptide (BNP) and C-reactive protein (CRP) levels and left ventricular function in hypervolemic hemodialysis patients.
  
  
  METHODS
  Twenty-six patients (18 male, 8 female; mean age 57.2 ± 12.7 years) who had high BNP and CRP levels and interdialytic weight gain (IDWG) were recruited for the study. Patients were randomly allocated to one of two groups, namely the supplementary ultrafiltration (sUF) group (n = 13), who had additional ultrafiltrations for 8 weeks, and the regular hemodialysis (rHD) group (n = 13), who continued regular dialysis treatments.
  
  
  RESULTS
  There were significant decreases in mean CRP and BNP levels and mean arterial blood pressure and significant improvements in left ventricular function in the sUF group, with no changes in the rHD group. Higher IDWG was observed in the rHD group compared to the sUF group after 8 weeks.
  
  
  CONCLUSIONS
  sUF may be effective in reducing inflammatory burden and improving cardiac function.
authors.affiliation: Department of Nephrology, Hacettepe University Faculty of Medicine, Ankara, Turkey. ryilmaz @ hacettepe.edu.tr
authors.forename: Rahmi
authors.initials: R
authors.lastname: Yilmaz
authors.forename: Mustafa
authors.initials: M
authors.lastname: Arici
authors.forename: Tolga
authors.initials: T
authors.lastname: Yildirim
authors.forename: Levent
authors.initials: L
authors.lastname: Sahiner
authors.forename: Kudret
authors.initials: K
authors.lastname: Aytemir
authors.forename: Bulent
authors.initials: B
authors.lastname: Altun
authors.forename: Yunus
authors.initials: Y
authors.lastname: Erdem
authors.forename: Cetin
authors.initials: C
authors.lastname: Turgan
mesh_terms: D000328:Adult; D000368:Aged; D002097:C-Reactive Protein / Q000378:metabolism; D004452:Echocardiography; D005260:Female; D006440:Hemofiltration; D006801:Humans; D007249:Inflammation / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D020097:Natriuretic Peptide, Brain / Q000097:blood; D006435:Renal Dialysis / Q000009:adverse effects*; D018487:Ventricular Dysfunction, Left / Q000209:etiology* / Q000378:metabolism*; D015430:Weight Gain
chemical_list: D020097:Natriuretic Peptide, Brain; D002097:C-Reactive Protein