title: [Kidney function in oncologic patients after cisplastin chemotherapy].
abstract: During examination of kidney function under cisplastin chemotherapy in oncologic patients the nephrotoxicity of the drug have been shown during 24 hours after administration. We found that in 24 hours after injection ofcisplastin in the dose 50 mg/m2 of the surface of the body, the excretion of creatinine, sodium, potassium, osmotic active compounds and chlorides is increased more than two times, indicating for disorder in osmolality, volume and ionic regulation of kidney function. The determined peculiarities are consequences of kidney injuries, which are confirmed by an increase in erythrocyte- and leucocyteuria. We showed that alterations in homeostatic kidney function is due to damage of renal tubules. Our study necessitates a need for renal protection during the whole period of cisplastin chemotherapy.
authors.forename: A I
authors.initials: AI
authors.lastname: Hozhenko
authors.forename: O M
authors.initials: OM
authors.lastname: Moskalenko
authors.forename: V M
authors.initials: VM
authors.lastname: Sirman
authors.forename: O O
authors.initials: OO
authors.lastname: ZhiZhnievs'ka
authors.forename: S A
authors.initials: SA
authors.lastname: Storozhenko
mesh_terms: D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000009:adverse effects*; D002945:Cisplatin / Q000008:administration & dosage / Q000009:adverse effects*; D003404:Creatinine / Q000652:urine; D005260:Female; D006417:Hematuria / Q000209:etiology / Q000503:physiopathology; D006801:Humans; D007677:Kidney Function Tests; D007684:Kidney Tubules / Q000187:drug effects* / Q000378:metabolism / Q000503:physiopathology; D008175:Lung Neoplasms / Q000188:drug therapy* / Q000652:urine; D008297:Male; D008353:Mannitol / Q000008:administration & dosage / Q000627:therapeutic use; D008875:Middle Aged; D009994:Osmolar Concentration; D011188:Potassium / Q000652:urine; D011776:Pyuria / Q000209:etiology / Q000503:physiopathology; D012964:Sodium / Q000652:urine
chemical_list: D000970:Antineoplastic Agents; D008353:Mannitol; D012964:Sodium; D003404:Creatinine; D002945:Cisplatin; D011188:Potassium