title: [The effects of low pre-pregnant lead exposure level on maternal bone turnover during gestation and lactation in mice].
abstract: OBJECTIVE
  To study the effects of low pre-pregnant lead exposure level on the mobilization of lead and calcium in maternal skeleton during gestation and lactation in mice.
  
  
  METHODS
  Seventy Kunming female mice were randomly divided into the lead exposure or control groups, 36 mice were exposed to lead by drinking water (50 mg/L) and 36 mice were exposed to deionized water for 4 weeks. The levels of calcium and lead in blood and femurs were measured on the 1st, 7th and 14th days during gestation and on the 1st,10th and 21st days during lactation with atomic absorption spectrophotometry using a heated graphite atomizer or flame atomic absorption spectrophotometry.
  
  
  RESULTS
  As compared with the pre-pregnant, at the end of lactation in exposure group the levels of calcium in blood and bones significantly decreased 18.5% and 17.75%, respectively, the levels of lead in blood significantly increased 65.22% and the levels of lead in bones significantly decreased 28.45% (P < 0.05). There was a significant negative correlation between the blood lead level and the bone lead level during gestation and lactation in exposure group (r = -0.904, P < 0.01). There were significant differences of lead and calcium levels during the gestation and lactation between exposure group and control group (P < 0.05).
  
  
  CONCLUSIONS
  The lead mobilization in maternal bone occurred during gestation and lactation in mice, which could be accelerated by the low pre-pregnant lead exposure.
authors.affiliation: Department of Occupational and Environmental Health, Hebei Medical University, Shijiazhuang, Hebei, China. songbootc@sohu.com
authors.forename: Bo
authors.initials: B
authors.lastname: Song
authors.forename: Bai-lin
authors.initials: BL
authors.lastname: Wu
authors.forename: Su-ju
authors.initials: SJ
authors.lastname: Sun
authors.forename: Rong
authors.initials: R
authors.lastname: Zhang
authors.forename: Feng-zhu
authors.initials: FZ
authors.lastname: Tan
authors.forename: Yu-jie
authors.initials: YJ
authors.lastname: Niu
mesh_terms: D000818:Animals; D016723:Bone Remodeling / Q000187:drug effects*; D001842:Bone and Bones / Q000187:drug effects* / Q000378:metabolism; D002118:Calcium / Q000097:blood / Q000378:metabolism*; D002136:Calcium, Dietary; D005260:Female; D007774:Lactation; D007854:Lead / Q000097:blood / Q000633:toxicity*; D051379:Mice; D008815:Mice, Inbred Strains; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects
chemical_list: D002136:Calcium, Dietary; D007854:Lead; D002118:Calcium