title: [Clinico-pathological conference report: sudden deterioration of general condition, hypokalemia and diabetes in an elderly man].
abstract: An elderly man had been treated for prostate cancer with radiation and neoadjuvant hormonal therapy. One year after the cessation of radiation therapy, the PSA value was found to be elevated. A non-steroidal antiandrogen bicalutamide was initiated to the patient. Due to poor treatment response the drug was changed for the GnRH agonist leuprorelin acetate, which upon injection caused a sudden deterioration of the patient's general condition. He was delirious and in pain, and was diagnosed with leukocytosis, hypokalemia, hyperglycemia and metabolic alkalosis. The patient was referred to the endocrinological clinic for evaluation of the metabolic-endocrinological problems. He succumbed to disseminated prostate cancer.
authors.affiliation: TAYS, sisätautien vastuualue.
authors.forename: Saara
authors.initials: S
authors.lastname: Metso
authors.forename: Johanna
authors.initials: J
authors.lastname: Arola
authors.forename: Merja
authors.initials: M
authors.lastname: Raade
authors.forename: Matti
authors.initials: M
authors.lastname: Välimäki
mesh_terms: D000368:Aged; D000471:Alkalosis / Q000209:etiology; D000726:Androgen Antagonists / Q000627:therapeutic use; D000813:Anilides / Q000627:therapeutic use; D018931:Antineoplastic Agents, Hormonal / Q000627:therapeutic use; D017809:Fatal Outcome; D006801:Humans; D006943:Hyperglycemia / Q000209:etiology; D007008:Hypokalemia / Q000209:etiology; D007964:Leukocytosis / Q000209:etiology; D016729:Leuprolide / Q000627:therapeutic use; D008297:Male; D009570:Nitriles / Q000627:therapeutic use; D017430:Prostate-Specific Antigen / Q000097:blood; D011471:Prostatic Neoplasms / Q000150:complications* / Q000188:drug therapy / Q000532:radiotherapy; D014105:Tosyl Compounds / Q000627:therapeutic use
chemical_list: D000726:Androgen Antagonists; D000813:Anilides; D018931:Antineoplastic Agents, Hormonal; D009570:Nitriles; D014105:Tosyl Compounds; C053541:bicalutamide; D017430:Prostate-Specific Antigen; D016729:Leuprolide