title: Genetic polymorphisms in the DNA repair gene XRCC1 and susceptibility to glioma in a Han population in northeastern China: a case-control study.
abstract: BACKGROUND
  Several single nucleotide polymorphisms (SNPs) in the X-ray cross-complementing group 1 (XRCC1) gene have been shown to influence DNA repair and to modify cancer susceptibility. To investigate the role of these loci further, we examined the association of three XRCC1 polymorphisms with the risk of gliomas in a Han population in northeastern China.
  
  
  METHODS
  Using a PCR-RFLP method, XRCC1 Arg194Trp, Arg280His and Arg399Gln were genotyped in 624 glioma patients and 580 healthy controls.
  
  
  RESULTS
  Significant differences in the distribution of the Arg399Gln allele were detected between glioma patients and healthy controls by a logistic regression analysis (OR=1.35, 95%CI 1.17-1.68, P=0.001). Our data also revealed that the Arg399Gln variant (allele A) carriers had an increased glioma risk compared to the wild-type (allele G) homozygous carriers (OR=1.40, 95%CI 1.12-1.76, P=0.003).
  
  
  CONCLUSIONS
  These results suggest that the XRCC1 Arg399Gln might influence the risk of developing glioma in a Han population in northeastern Chinese.
authors.affiliation: Department of Neurosurgery, First Affiliated Hospital of Harbin Medical University, Harbin 150001, People's Republic of China. wangdianhong1967@163.com
authors.forename: Dianhong
authors.initials: D
authors.lastname: Wang
authors.forename: Yongzhen
authors.initials: Y
authors.lastname: Hu
authors.forename: Haidong
authors.initials: H
authors.lastname: Gong
authors.forename: Jingwen
authors.initials: J
authors.lastname: Li
authors.forename: Yanhai
authors.initials: Y
authors.lastname: Ren
authors.forename: Guozhong
authors.initials: G
authors.lastname: Li
authors.forename: Aiguo
authors.initials: A
authors.lastname: Liu
mesh_terms: D000293:Adolescent; D000328:Adult; D044466:Asian People / Q000235:genetics*; D016022:Case-Control Studies; D002681:China / Q000453:epidemiology; D004260:DNA Repair; D004268:DNA-Binding Proteins / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease; D005910:Glioma / Q000453:epidemiology / Q000235:genetics*; D006801:Humans; D008297:Male; D008875:Middle Aged; D016133:Polymerase Chain Reaction; D012150:Polymorphism, Restriction Fragment Length; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D012307:Risk Factors; D000076105:X-ray Repair Cross Complementing Protein 1; D055815:Young Adult
chemical_list: D004268:DNA-Binding Proteins; D000076105:X-ray Repair Cross Complementing Protein 1; C000619371:XRCC1 protein, human