title: An excellent enzymatic lactic acid biosensor with ZnO nanowires-gated AlGaAs/GaAs high electron mobility transistor.
abstract: An excellent biosensor with ZnO nanowires-gated AlGaAs/GaAs high electron mobility transistor (HEMT) was used to detect lactic acid. Due to the new structure, addition of the Si-doped GaAs cap layer, the HEMT biosensor could detect a wide range of lactic acid concentrations from 0.03 nM to 300 mM. The novel biosensor exhibiting good performance along with fast response, high sensitivity, wide detection range, and long-term stability, can be integrated with a commercially available transmitter to realize lactic acid detection.
authors.affiliation: State Key Laboratory for Advanced Metals and Materials, School of Materials Science and Engineering, University of Science and Technology Beijing, Beijing, 100083, People's Republic of China.
authors.forename: Siwei
authors.initials: S
authors.lastname: Ma
authors.forename: Qingliang
authors.initials: Q
authors.lastname: Liao
authors.forename: Hanshuo
authors.initials: H
authors.lastname: Liu
authors.forename: Yu
authors.initials: Y
authors.lastname: Song
authors.forename: Ping
authors.initials: P
authors.lastname: Li
authors.forename: Yunhua
authors.initials: Y
authors.lastname: Huang
authors.forename: Yue
authors.initials: Y
authors.lastname: Zhang
mesh_terms: D000535:Aluminum / Q000737:chemistry*; D001152:Arsenicals / Q000737:chemistry*; D015374:Biosensing Techniques / Q000295:instrumentation* / Q000379:methods; D004800:Enzymes, Immobilized / Q000737:chemistry* / Q000378:metabolism; D005708:Gallium / Q000737:chemistry*; D019344:Lactic Acid / Q000032:analysis* / Q000378:metabolism; D057230:Limit of Detection; D006899:Mixed Function Oxygenases / Q000737:chemistry / Q000378:metabolism; D053770:Nanowires / Q000737:chemistry*; D015034:Zinc Oxide / Q000737:chemistry*
chemical_list: D001152:Arsenicals; D004800:Enzymes, Immobilized; C043055:gallium arsenide; D019344:Lactic Acid; D005708:Gallium; D000535:Aluminum; D006899:Mixed Function Oxygenases; C021497:lactate 2-monooxygenase; D015034:Zinc Oxide