title: The plasma clearance of the Fusarium toxin deoxynivalenol (DON) is decreased in endotoxemic pigs.
abstract: The plasma elimination kinetics of the Fusarium toxin deoxynivalenol (DON) was investigated in male castrated pigs (40.4±3.7 kg) when infused intravenously either alone (100 μg/kg/h, n=6) or together with lipopolysaccharides (LPS, 7.5 μg/kg/h, n=6). The maximum DON concentration after one hour of infusion was significantly higher by 61% in the DON+LPS Group compared to pigs infused with DON alone. The area under the plasma DON concentration vs. time curve of the DON+LPS Group was approximately twice as high as that of the DON Group after 24h while the initial (0.63 vs. 0.6 h) and terminal half-lifes (2.97 vs. 2.30 h) remained uninfluenced. The apparent volume of distribution and the plasma clearance were significantly lower for the DON+LPS Group compared to the DON Group (2.14 vs. 1.45 L/kg and 11.9 vs. 5.87 mL/kg/min). Glucuronidated DON seemed to persist longer in the DON+LPS Group. In conclusion, clearance of DON was decreased during an LPS induced acute phase reaction in pigs. Whether the higher plasma DON concentrations in endotoxemic pigs are due to a hemodynamically associated longer persistence of the DON glucuronide or because of an altered glucuronidation activity needs to be examined further.
authors.affiliation: Institute of Animal Nutrition, Friedrich-Loeffler-Institute (FLI), Federal Research Institute for Animal Health, Braunschweig, Germany. sven.daenicke@fli.bund.de
authors.forename: Sven
authors.initials: S
authors.lastname: Dänicke
authors.forename: Bianca
authors.initials: B
authors.lastname: Brosig
authors.forename: Stefan
authors.initials: S
authors.lastname: Kahlert
authors.forename: Patricia
authors.initials: P
authors.lastname: Panther
authors.forename: Nicole
authors.initials: N
authors.lastname: Reinhardt
authors.forename: Anne-Kathrin
authors.initials: AK
authors.lastname: Diesing
authors.forename: Jeannette
authors.initials: J
authors.lastname: Kluess
authors.forename: Susanne
authors.initials: S
authors.lastname: Kersten
authors.forename: Hana
authors.initials: H
authors.lastname: Valenta
authors.forename: Hermann-Josef
authors.initials: HJ
authors.lastname: Rothkötter
mesh_terms: D000284:Administration, Oral; D000818:Animals; D001774:Blood Chemical Analysis / Q000662:veterinary; D019446:Endotoxemia / Q000382:microbiology / Q000503:physiopathology*; D005670:Fusarium / Q000378:metabolism*; D020719:Glucuronides / Q000378:metabolism; D006207:Half-Life; D007275:Injections, Intravenous / Q000662:veterinary; D007700:Kinetics; D008070:Lipopolysaccharides / Q000097:blood; D008297:Male; D013552:Swine; D014255:Trichothecenes / Q000097:blood* / Q000633:toxicity*
chemical_list: D020719:Glucuronides; D008070:Lipopolysaccharides; D014255:Trichothecenes; C007262:deoxynivalenol