title: Investigation of the effect of ibuprofen on the healing of osseointegrated oral implants.
abstract: OBJECTIVE
  To investigate the effect of a 1-week postoperative course of 600 mg of ibuprofen taken four times a day on marginal bone level around oral implants.
  
  
  METHODS
  Twenty-eight patients were allocated to the ibuprofen group (14 patients) or no-ibuprofen group (14 patients). Overall, 57 implants were inserted, 31 implants in the ibuprofen group and 26 in the no-ibuprofen group. The primary outcome measure was the change in marginal bone level around oral implants from baseline (2 weeks postplacement) to the 3- and 6-month radiographic examinations. The paralleling technique and a film holder coupled to a beam-aiming device were used to take the periapical radiographs. Measurement of changes in bone level was made using a viewing box and ×8 magnifier.
  
  
  RESULTS
  Three subjects were withdrawn from the therapy early as they did not complete the dose of ibuprofen (e.g. because of self-reported stomach upset). The mean marginal mesial bone loss from the baseline was 0.37 mm at the 3-month and 0.27 mm at the 6-month follow up for the ibuprofen group, while the corresponding values for the no-ibuprofen group were 0.15 mm and 0.08 mm. The mean marginal distal bone loss from the baseline was 0.42 mm at the 3-month and 0.2 mm at the 6-month follow up for the ibuprofen group, while the corresponding values for the no-ibuprofen group were 0.08 mm and 0.15 mm. There were no significant differences between the ibuprofen and no-ibuprofen groups when comparing the bone changes.
  
  
  CONCLUSIONS
  Administration of a short course of systemic ibuprofen for postoperative pain management following implant insertion may not have a significant effect on the marginal bone loss around oral implants in the early healing phase.
authors.affiliation: Department of Oral Surgery, Hama Dental School, Hama, Syria. salah.sakka@hotmail.com
authors.forename: Salah
authors.initials: S
authors.lastname: Sakka
authors.forename: Salah I
authors.initials: SI
authors.lastname: Hanouneh
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D016301:Alveolar Bone Loss / Q000209:etiology*; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology; D016861:Cyclooxygenase Inhibitors / Q000494:pharmacology*; D015921:Dental Implants / Q000009:adverse effects*; D005260:Female; D006801:Humans; D007052:Ibuprofen / Q000494:pharmacology*; D008297:Male; D008875:Middle Aged; D016348:Osseointegration / Q000187:drug effects*; D018709:Statistics, Nonparametric; D014945:Wound Healing / Q000187:drug effects*; D055815:Young Adult
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D016861:Cyclooxygenase Inhibitors; D015921:Dental Implants; D007052:Ibuprofen