title: Sclerosing angiomatoid nodular transformation of the spleen (SANT): multimodality imaging appearance of five cases with radiology-pathology correlation.
abstract: OBJECTIVE
  Sclerosing angiomatoid nodular transformation (SANT) is an extremely rare splenic lesion first reported in 2004, representing an unusual reaction of splenic red pulp to stromal inflammation or vascular injury. There are very few descriptions of the imaging appearance of SANT in the literature. We present five pathologically proven cases of SANT, with a description of the imaging appearance using multiple different modalities, as well as correlation with the histopathologic features of the lesion.
  
  
  CONCLUSIONS
  While there are several imaging features of SANT which have been described in the literature, it is not routinely possible to make a prospective diagnosis based on the imaging features alone. Moreover, it may not be possible to exclude malignancy based on the imaging features, and splenectomy may be required in certain cases.
authors.affiliation: Department of Radiology, Johns Hopkins University School of Medicine, JHOC 3251, 601 N. Caroline Street, Baltimore, MD 21287, USA. srsraman3@gmail.com
authors.forename: Siva P
authors.initials: SP
authors.lastname: Raman
authors.forename: Aatur
authors.initials: A
authors.lastname: Singhi
authors.forename: Karen M
authors.initials: KM
authors.lastname: Horton
authors.forename: Ralph H
authors.initials: RH
authors.lastname: Hruban
authors.forename: Elliot K
authors.initials: EK
authors.lastname: Fishman
mesh_terms: D003937:Diagnosis, Differential; D003952:Diagnostic Imaging; D006801:Humans; D008279:Magnetic Resonance Imaging; D012598:Sclerosis; D013154:Spleen / Q000098:blood supply; D013156:Splenectomy; D013158:Splenic Diseases / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery; D014057:Tomography, X-Ray Computed