title: The common C49620T polymorphism in the sulfonylurea receptor gene SUR1 (ABCC8) in patients with gestational diabetes and subsequent glucose metabolism abnormalities.
abstract: OBJECTIVE
  The aim of this study is to investigate the relationship between the common C49620T polymorphism in the sulfonylurea receptor (SUR1) gene and glucose metabolism, β-cell secretory function and insulin resistance in women with a history of gestational diabetes (GDM).
  
  
  METHODS
  Study group included 199 women, diagnosed GDM within the last 5-12 years and control group of comparable 50 women in whom GDM was excluded during pregnancy. Blood glucose and insulin levels were measured during oral glucose tolerance test. Indices of insulin resistance (HOMA-IR) and β-cell function (HOMA %B) were calculated. In all patients, the C49620T polymorphism in intron 15 of the SUR1 gene was determined.
  
  
  RESULTS
  The distribution of the studied polymorphism in the two groups did not differ from each other (χ(2) = 0.34, P = 0.8425). No association between the distribution of polymorphisms and coexisting glucose metabolism disorders (χ(2) = 7,13, P = 0, 3043) was found. No association was also observed between the polymorphism and HOMA %B or HOMA-IR.
  
  
  CONCLUSIONS
  The polymorphism C49620T in the SUR1 gene is not associated with insulin resistance and/or insulin secretion in women with a history of GDM and does not affect the development of GDM, or the development of glucose intolerance in the studied population.
authors.affiliation: Department of Diabetology and Internal Diseases, Pomeranian Medical University, Szczecin, Poland. pmoleda@wp.pl
authors.forename: Piotr
authors.initials: P
authors.lastname: Molęda
authors.forename: Agnieszka
authors.initials: A
authors.lastname: Bińczak-Kuleta
authors.forename: Katarzyna
authors.initials: K
authors.lastname: Homa
authors.forename: Krzysztof
authors.initials: K
authors.lastname: Safranow
authors.forename: Zbigniew
authors.initials: Z
authors.lastname: Celewicz
authors.forename: Anhelli
authors.initials: A
authors.lastname: Syrenicz
authors.forename: Adam
authors.initials: A
authors.lastname: Stefański
authors.forename: Aneta
authors.initials: A
authors.lastname: Fronczyk
authors.forename: Lilianna
authors.initials: L
authors.lastname: Majkowska
mesh_terms: D018528:ATP-Binding Cassette Transporters / Q000235:genetics* / Q000378:metabolism; D000328:Adult; D000886:Anthropometry; D001786:Blood Glucose / Q000378:metabolism; D016640:Diabetes, Gestational / Q000235:genetics* / Q000378:metabolism; D005260:Female; D005947:Glucose / Q000378:metabolism*; D005951:Glucose Tolerance Test; D006801:Humans; D007328:Insulin / Q000097:blood; D007333:Insulin Resistance; D050417:Insulin-Secreting Cells / Q000166:cytology; D011110:Polymorphism, Genetic; D024661:Potassium Channels, Inwardly Rectifying / Q000235:genetics* / Q000378:metabolism; D011247:Pregnancy; D011955:Receptors, Drug / Q000235:genetics* / Q000378:metabolism; D064233:Sulfonylurea Receptors
chemical_list: C577507:ABCC8 protein, human; D018528:ATP-Binding Cassette Transporters; D001786:Blood Glucose; D007328:Insulin; D024661:Potassium Channels, Inwardly Rectifying; D011955:Receptors, Drug; D064233:Sulfonylurea Receptors; D005947:Glucose