title: Effect of intra-amygdala injection of lipopolysaccharide on kindling epileptogenesis in adult rats.
abstract: BACKGROUND
  Contribution of neuroinflammation and epilepsy in the mature brain has elicited contradictory results with either excitatory or inhibitory effects. The amygdala is one of the main parts of the limbic system susceptible to insults that lead to neuroinflammation and epilepsy. This study evaluates the effect of chronic inflammation of the rat amygdala induced by lipopolysaccharide (LPS) on kindling epileptogenesis.
  
  
  METHODS
  LPS (5µg/rat) was infused once daily into the basolateral amygdala (BLA) of adult rats. Daily electrical stimulation (150 - 300 µA, 100 Hz, monophasic square wave stimulus of 1 msec per wave, 2 sec duration) was delivered into BLA 30 min after LPS injections until the animals became fully kindled.
  
  
  RESULTS
  LPS had no significant effect on the development of focal and generalized seizures.
  
  
  CONCLUSIONS
  The type of neural system exposed to LPS and its specific electrophysiological properties seems to ascertain the final excitatory or inhibitory outcome.
authors.affiliation: Department of Physiology and Pharmacology, Pasteur Institute of Iran, Tehran, Iran.
authors.forename: Zhamak
authors.initials: Z
authors.lastname: Akhlaghi
authors.forename: Mohammad
authors.initials: M
authors.lastname: Sayyah
authors.forename: Mehrdad
authors.initials: M
authors.lastname: Mokhtari
authors.forename: Amin
authors.initials: A
authors.lastname: Ahmadi
mesh_terms: D000679:Amygdala / Q000187:drug effects* / Q000503:physiopathology; D000818:Animals; D004195:Disease Models, Animal; D004827:Epilepsy / Q000209:etiology* / Q000503:physiopathology; D007267:Injections; D007696:Kindling, Neurologic / Q000187:drug effects*; D008070:Lipopolysaccharides / Q000008:administration & dosage / Q000494:pharmacology*; D008297:Male; D051381:Rats; D017208:Rats, Wistar
chemical_list: D008070:Lipopolysaccharides