title: P300 latency and amplitude in Alzheimer's disease: a systematic review.
abstract: The P300 plays a key role as a method for monitoring and evaluating dementia, including Alzheimer's disease.
  
  
  OBJECTIVE
  The goal of this study was to search for articles which analyzed P300 latency and amplitude values in Alzheimer's disease.
  
  
  METHODS
  We searched in the following databases: Web of Science, Pub Med, Psyc Info, Medline, Biological Abstracts and Scielo using the following keywords: speed of information processing, processing speed, information processing, aged, older, elderly, older people, alzheimer dementia, alzheimer disease, Alzheimer and cross-references of selected articles.
  
  
  RESULTS
  We found eight studies matching the inclusion criteria. These studies showed that there is a consensus on a P300 latency increase of elderly patients with Alzheimer's disease compared with subjects without the disease. However, it appears that, with respect to the P300 amplitude, there is still no consensus; however, it may be related to different methodological variables adopted in the reviewed studies.
  
  
  CONCLUSIONS
  There is a need to standardize the variables involved in P300 measurement for senior citizens with Alzheimer's disease in order to be able to compare P300 latency and amplitude values for this population.
authors.affiliation: Universidade Estadual Paulista Júlio de Mesquita Filho.
authors.forename: Renata Valle
authors.initials: RV
authors.lastname: Pedroso
authors.forename: Francisco J
authors.initials: FJ
authors.lastname: Fraga
authors.forename: Danilla Icassatti
authors.initials: DI
authors.lastname: Corazza
authors.forename: Carla Andrezza Almeida
authors.initials: CA
authors.lastname: Andreatto
authors.forename: Flávia Gomes de Melo
authors.initials: FG
authors.lastname: Coelho
authors.forename: José Luiz Riani
authors.initials: JL
authors.lastname: Costa
authors.forename: Ruth Ferreira
authors.initials: RF
authors.lastname: Santos-Galduróz
mesh_terms: D000368:Aged; D000544:Alzheimer Disease / Q000503:physiopathology*; D018913:Event-Related Potentials, P300 / Q000502:physiology*; D005072:Evoked Potentials, Auditory / Q000502:physiology*; D006801:Humans; D011930:Reaction Time / Q000502:physiology*