title: Simultaneous voltammetric determination of nitazoxanide and ofloxacin in pharmaceutical formulation.
abstract: A simple, sensitive and highly selective electrochemical method was developed for the simultaneous determination of nitazoxanide and ofloxacin in aqueous media (Britton-Robinson buffer, pH-8.36) on a hanging mercury drop electrode (HMDE) using differential pulse polarography (DPP). Using DPP a separation of about 936 mV between the peak oxidation potentials of nitazoxanide and ofloxacin present in binary mixtures was obtained. The quantification limits for the simultaneous determination of nitazoxanide and ofloxacin were 0.083 μg/ml and 0.208 μg/ml, respectively. The proposed method was successfully applied for the simultaneous determination of nitazoxanide and ofloxacin in bulk drug and pharmaceutical tablet formulation.
authors.affiliation: Department of Pharmacy, G. H. Patel Building, Donor's Plaza, The Maharaja Sayajirao University of Baroda, Fatehgunj, Vadodara-390 002, India.
authors.forename: Shital
authors.initials: S
authors.lastname: Gandhi
authors.forename: V
authors.initials: V
authors.lastname: Mehta
authors.forename: Sadhana
authors.initials: S
authors.lastname: Rajput