title: Two new compounds from the roots of Rhodiola crenulata.
abstract: Two new compounds, named (3R,5R,8R)-3-O-[α-l-arabinopyranosyl (1 → 6)-β-d-glucopyranosyl]-5-hydroxymegastigma-6,7-dien-9-one (1) and (1R)-1-O-(β-d-glucopyranosyl)-phenylethylene glycol (2), were isolated from the extract of Rhodiola crenulata. Their structures were determined on the basis of various spectroscopic methods, including IR, HR-ESI-MS, 1D and 2D NMR, and chemical evidences. The cytotoxicity of these two compounds was evaluated by using MTT method.
authors.affiliation: State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Chinese Academy of Medical Sciences, Peking Union Medical College, Institute of Materia Medica, Beijing, China.
authors.forename: Ya-Nan
authors.initials: YN
authors.lastname: Yang
authors.forename: Fan
authors.initials: F
authors.lastname: Zhang
authors.forename: Zi-Ming
authors.initials: ZM
authors.lastname: Feng
authors.forename: Jian-Shuang
authors.initials: JS
authors.lastname: Jiang
authors.forename: Pei-Cheng
authors.initials: PC
authors.lastname: Zhang
mesh_terms: D005026:Ethylene Glycols / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D005960:Glucosides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D045792:Norisoprenoids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D019906:Nuclear Magnetic Resonance, Biomolecular; D018517:Plant Roots / Q000737:chemistry; D029771:Rhodiola / Q000737:chemistry*; D012503:Saponins / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D013237:Stereoisomerism; D014315:Triterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology
chemical_list: C576863:(1R)-1-O-(beta-D-glucopyranosyl)phenylethylene glycol; C576862:(3R,5R,8R)-3-O-(alpha-L-arabinopyranosyl-(1-6)-beta-D-glucopyranosyl)-5-hydroxymegastigma-6,7-dien-9-one; D005026:Ethylene Glycols; D005960:Glucosides; D045792:Norisoprenoids; D012503:Saponins; D014315:Triterpenes