title: Pediatric acute lymphoblastic leukemia with a t(8;14)(q11.2;q32): B-cell disease with a high proportion of Down syndrome: a Children's Oncology Group study.
abstract: The rare translocation t(8;14)(q11.2;q32) has been described in patients with B-cell acute lymphoblastic leukemia (ALL), particularly patients with Down syndrome (DS). We describe patients with the t(8;14)(q11.2;q32) who were identified by the Children's Oncology Group (COG) ALL cytogenetics database, expanding our previous report of 10 patients with this translocation. Twenty-two such patients were treated with COG protocols. All patients had B-cell ALL, and seven (31.8%) had DS. None of the children with DS had an event; thus, these patients had a superior estimated 5-year event-free survival (EFS) compared to non-DS patients (100% vs. 50.1 ± 17.7%; P = 0.04). Only one patient (4.5%) had a concomitant Philadelphia chromosome t(9;22)(q34;q11.2). The cytogenetics data of two additional patients, who were not eligible for COG protocols, are also included in this report. In conclusion, ALL patients with the recurring translocation t(8;14)(q11.2;q32) have the B-cell phenotype and a high percentage have DS. Children with DS and the t(8;14)(q11.2;q34) have improved EFS using standard COG therapy compared to non-DS patients. We did not find an increased number of patients with a concomitant Philadelphia chromosome in this population.
authors.affiliation: Children's Hospitals and Clinics of Minnesota, Minneapolis, MN, USA. yoav.messinger@childrensmn.org
authors.forename: Yoav H
authors.initials: YH
authors.lastname: Messinger
authors.forename: Rodney R
authors.initials: RR
authors.lastname: Higgins
authors.forename: Meenakshi
authors.initials: M
authors.lastname: Devidas
authors.forename: Stephen P
authors.initials: SP
authors.lastname: Hunger
authors.forename: Andrew J
authors.initials: AJ
authors.lastname: Carroll
authors.forename: Nyla A
authors.initials: NA
authors.lastname: Heerema
mesh_terms: D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D002883:Chromosomes, Human, Pair 14; D002898:Chromosomes, Human, Pair 8; D020732:Cytogenetic Analysis; D018572:Disease-Free Survival; D004314:Down Syndrome / Q000150:complications / Q000188:drug therapy / Q000235:genetics*; D005260:Female; D006801:Humans; D053208:Kaplan-Meier Estimate; D008297:Male; D015452:Precursor B-Cell Lymphoblastic Leukemia-Lymphoma / Q000150:complications / Q000188:drug therapy / Q000235:genetics*; D014178:Translocation, Genetic; D016896:Treatment Outcome