title: Synthesis of triptorelin lactate catalyzed by lipase in organic media.
abstract: Triptorelin lactate was successfully synthesized by porcine pancreatic lipase (PPL) in organic solvents. The effects of acyl donor, substrate ratio, organic solvent, temperature, and water activity were investigated. Under the optimum conditions, a yield of 30% for its ester could be achieved in the reaction for about 48 h.
authors.affiliation: Department of Food Science and Engineering, Jilin University, Changchun 130021, China.
authors.forename: Hong
authors.initials: H
authors.lastname: Zhuang
authors.affiliation: Key Laboratory for Molecular Enzymology and Engineering of Ministry of Education, College of Life Science, Jilin University, Changchun 130021, China.
authors.forename: Zhi
authors.initials: Z
authors.lastname: Wang
authors.affiliation: Key Laboratory for Molecular Enzymology and Engineering of Ministry of Education, College of Life Science, Jilin University, Changchun 130021, China.
authors.forename: Jiaxin
authors.initials: J
authors.lastname: Wang
authors.affiliation: Key Laboratory for Molecular Enzymology and Engineering of Ministry of Education, College of Life Science, Jilin University, Changchun 130021, China.|College of Chemistry, Jilin University, Changchun 130023, China.
authors.forename: Hong
authors.initials: H
authors.lastname: Zhang
authors.affiliation: Key Laboratory for Molecular Enzymology and Engineering of Ministry of Education, College of Life Science, Jilin University, Changchun 130021, China.
authors.forename: Erna
authors.initials: E
authors.lastname: Xun
authors.affiliation: Key Laboratory for Molecular Enzymology and Engineering of Ministry of Education, College of Life Science, Jilin University, Changchun 130021, China.
authors.forename: Ge
authors.initials: G
authors.lastname: Chen
authors.affiliation: Key Laboratory for Molecular Enzymology and Engineering of Ministry of Education, College of Life Science, Jilin University, Changchun 130021, China.
authors.forename: Hong
authors.initials: H
authors.lastname: Yue
authors.affiliation: Department of Food Science and Engineering, Jilin University, Changchun 130021, China.
authors.forename: Ning
authors.initials: N
authors.lastname: Tang
authors.affiliation: Key Laboratory for Molecular Enzymology and Engineering of Ministry of Education, College of Life Science, Jilin University, Changchun 130021, China.
authors.forename: Lei
authors.initials: L
authors.lastname: Wang
mesh_terms: D000818:Animals; D001419:Bacteria / Q000201:enzymology; D002384:Catalysis; D004951:Esterification; D006863:Hydrogen-Ion Concentration; D007700:Kinetics; D007773:Lactates / Q000737:chemistry*; D008049:Lipase / Q000378:metabolism*; D009930:Organic Chemicals / Q000737:chemistry*; D012997:Solvents / Q000737:chemistry*; D013552:Swine; D013696:Temperature; D017329:Triptorelin Pamoate / Q000031:analogs & derivatives* / Q000138:chemical synthesis* / Q000737:chemistry*; D014867:Water / Q000737:chemistry*
chemical_list: D007773:Lactates; D009930:Organic Chemicals; D012997:Solvents; C000601071:triptorelin lactate; D014867:Water; D017329:Triptorelin Pamoate; D008049:Lipase