title: Diversity oriented synthesis of pyran based polyfunctional stereogenic macrocyles and their conformational studies.
abstract: A new approach to synthesize a homologous series of 14-, 15-, and 16-membered drug-like, macrocyclic glycoconjugates involving TBAHS promoted azide-propenone intramolecular cycloaddition in designed C-glycopyranosyl butenones from a simple sugar d-glucose and d-mannose is reported.
authors.affiliation: Medicinal and Process Chemistry Division, Sophisticated Analytical Instrumentation Facility, Endocrinology Division, CSIR-Central Drug Research Institute, Lucknow-226001, U.P., India.
authors.forename: Arya
authors.initials: A
authors.lastname: Ajay
authors.forename: Shrikant
authors.initials: S
authors.lastname: Sharma
authors.forename: Munna Prasad
authors.initials: MP
authors.lastname: Gupt
authors.forename: Vikas
authors.initials: V
authors.lastname: Bajpai
authors.lastname: Hamidullah
authors.forename: Brijesh
authors.initials: B
authors.lastname: Kumar
authors.forename: Mahabir Prasad
authors.initials: MP
authors.lastname: Kaushik
authors.forename: Rituraj
authors.initials: R
authors.lastname: Konwar
authors.forename: Ravi Sankar
authors.initials: RS
authors.lastname: Ampapathi
authors.forename: Rama Pati
authors.initials: RP
authors.lastname: Tripathi
mesh_terms: D005947:Glucose / Q000737:chemistry; D006001:Glycoconjugates / Q000138:chemical synthesis* / Q000737:chemistry; D047028:Macrocyclic Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D008358:Mannose / Q000737:chemistry; D008968:Molecular Conformation; D015394:Molecular Structure; D011714:Pyrans / Q000138:chemical synthesis* / Q000737:chemistry; D013237:Stereoisomerism
chemical_list: D006001:Glycoconjugates; D047028:Macrocyclic Compounds; D011714:Pyrans; D005947:Glucose; D008358:Mannose