title: [A severe falciparum malaria case successfully treated by exchange transfusion as an adjunct therapy].
abstract: Plasmodium falciparum malaria is a type of malaria with high fatality rate despite optimal antimalarial treatment. Exchange transfusion (ET) is successfully used as a means of supportive therapy in severe P. falciparum malaria cases with hyperparasitemia. Herein, we present a case with hyperparasitemia, who received erythrocyte ET therapy due to lack of clinical response to antimalarial treatment. A 24-year-old male patient was admitted to our emergency clinic with the complaints of fever that persisted for 10 days, headache, nausea-vomiting, and impaired consciousness. Medical history revealed that he had been working in Sudan, Africa and returned back 12 days ago. On physical examination; he had fever, hypotension, tachycardia, subicterus and impaired cooperation. Laboratory examination revealed pancytopenia, elevated C-reactive protein, hyperbilirubinemia, hyponatremia, elevated creatinine level and hematuria. On thick blood smear and thin blood smear examinations, multiple (> 5%) trophozoites and gametocytes indicating P.falciparum species were observed. The case was diagnosed as P.falciparum malaria and parenteral fluid support, dopamine infusion, meropenem (IV), doxycycline (PO) and quinine sulphate (PO) were initiated in the intensive care unit. On reevaluation of the patient on the third day of hospitalization, it was observed that arterial hypotension and fever were persistent, anemia and trombocytopenia deteriorated and on thick blood smear parasitemiea was not decreased. It was decided to apply automated erythrocyte ET. After ET, patient's medical status was quickly improved and patient was discharged on the 7th day of hospitalization. In conclusion, it was noted that in addition to antimalarial treatment, erythrocyte ET may provide dramatic improvement in severe cases of P.falciparum malaria with hyperparasitemia.
authors.affiliation: Başkent University Adana Teaching and Research Center, Department of Infectious Diseases and Clinical Microbiology, Adana, Turkey. yusufziya2002@hotmail.com
authors.forename: Yusuf Ziya
authors.initials: YZ
authors.lastname: Demiroğlu
authors.forename: Ilknur
authors.initials: I
authors.lastname: Kozanoğlu
authors.forename: Tuba
authors.initials: T
authors.lastname: Turunç
authors.forename: Ebru
authors.initials: E
authors.lastname: Kurşun
authors.forename: Hande
authors.initials: H
authors.lastname: Arslan
mesh_terms: D000962:Antimalarials / Q000008:administration & dosage; D002316:Cardiotonic Agents / Q000008:administration & dosage; D004298:Dopamine / Q000008:administration & dosage; D004318:Doxycycline / Q000008:administration & dosage; D017707:Erythrocyte Transfusion; D005440:Fluid Therapy; D006801:Humans; D016778:Malaria, Falciparum / Q000175:diagnosis / Q000628:therapy*; D008297:Male; D000077731:Meropenem; D011803:Quinine / Q000008:administration & dosage; D013397:Sudan; D013845:Thienamycins / Q000008:administration & dosage; D014195:Travel; D014421:Turkey; D055815:Young Adult
chemical_list: D000962:Antimalarials; D002316:Cardiotonic Agents; D013845:Thienamycins; D011803:Quinine; D000077731:Meropenem; D004318:Doxycycline; D004298:Dopamine