title: Continuous endocytic recycling of tight junction proteins: how and why?
abstract: Tight junctions consist of many proteins, including transmembrane and associated cytoplasmic proteins, which act to provide a barrier regulating transport across epithelial and endothelial tissues. These junctions are dynamic structures that are able to maintain barrier function during tissue remodelling and rapidly alter it in response to extracellular signals. Individual components of tight junctions also show dynamic behaviour, including migration within the junction and exchange in and out of the junctions. In addition, it is becoming clear that some tight junction proteins undergo continuous endocytosis and recycling back to the plasma membrane. Regulation of endocytic trafficking of junctional proteins may provide a way of rapidly remodelling junctions and will be the focus of this chapter.
authors.affiliation: Department of Biology and Biochemistry, Centre for Regenerative Medicine, University of Bath, Bath BA2 7AY, U.K. ac270@bath.ac.uk
authors.forename: Andrew D
authors.initials: AD
authors.lastname: Chalmers
authors.forename: Paul
authors.initials: P
authors.lastname: Whitley
mesh_terms: D000818:Animals; D004705:Endocytosis; D056827:Endosomal Sorting Complexes Required for Transport / Q000378:metabolism; D011992:Endosomes / Q000502:physiology; D004847:Epithelial Cells / Q000166:cytology / Q000378:metabolism / Q000502:physiology; D006801:Humans; D008247:Lysosomes / Q000502:physiology; D062725:Tight Junction Proteins / Q000378:metabolism*; D019108:Tight Junctions / Q000378:metabolism
chemical_list: D056827:Endosomal Sorting Complexes Required for Transport; D062725:Tight Junction Proteins