title: NK/T-cell lymphoma of bilateral adrenal glands in a patient with pyothorax.
abstract: Primary lymphoma of adrenal glands is rare, and non-B-cell lymphoma associated with pyothorax is also very rare. Here we report the first autopsy case of non-B-cell lymphoma in bilateral adrenal glands of a 79-year-old woman with pyothorax who had an aggressive clinical course. Immunohistochemically, tumor cells showed CD3+, CD45RO+, CD5-, CD7-, CD4-, CD8-, CD10-, CD20-, CD30-, CD79a-, CD138-, CD56-, granzyme B-, TIA-1+ and ALK-. In addition, tumor cells were strongly EBER1-positive by in situ hybridization. In genomic DNA of tumor cells, T-cell receptor rearrangements were not detected by southern blotting. We finally diagnosed this case as extranodal NK/T-cell lymphoma (nasal type). Virtual slides: The virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/8050621197741854.
authors.affiliation: Department of Pathology, Sapporo Medical University, South-1, West-17, Chuo-ku, Sapporo, 060-8556, Japan. tukahara@sapmed.ac.jp
authors.forename: Tomohide
authors.initials: T
authors.lastname: Tsukahara
authors.forename: Akira
authors.initials: A
authors.lastname: Takasawa
authors.forename: Masaki
authors.initials: M
authors.lastname: Murata
authors.forename: Kazuyoshi
authors.initials: K
authors.lastname: Okumura
authors.forename: Masato
authors.initials: M
authors.lastname: Nakayama
authors.forename: Noriyuki
authors.initials: N
authors.lastname: Sato
authors.forename: Tadashi
authors.initials: T
authors.lastname: Hasegawa
mesh_terms: D000310:Adrenal Gland Neoplasms / Q000737:chemistry / Q000209:etiology* / Q000235:genetics / Q000276:immunology / Q000473:pathology / Q000821:virology; D000368:Aged; D001344:Autopsy; D014408:Biomarkers, Tumor / Q000032:analysis; D015139:Blotting, Southern; D016724:Empyema, Pleural / Q000150:complications* / Q000276:immunology / Q000473:pathology; D017809:Fatal Outcome; D005260:Female; D015329:Gene Rearrangement, T-Lymphocyte; D004854:Herpesvirus 4, Human / Q000235:genetics; D006801:Humans; D007150:Immunohistochemistry; D017403:In Situ Hybridization; D054391:Lymphoma, Extranodal NK-T-Cell / Q000737:chemistry / Q000209:etiology* / Q000235:genetics / Q000276:immunology / Q000473:pathology / Q000821:virology; D012367:RNA, Viral / Q000235:genetics; D014057:Tomography, X-Ray Computed
chemical_list: D014408:Biomarkers, Tumor; C099537:Epstein-Barr virus encoded RNA 1; D012367:RNA, Viral