title: Comprehensive review on oral disintegrating films.
abstract: Fast-dissolving drug-delivery systems were first developed in the late 1970s as an alternative to tablets, capsules, and syrups for pediatric and geriatric patients who experience difficulties swallowing traditional oral solid dosage forms. In response to this need, a variety of orally disintegrating tablet (ODT) formats were commercialized, which disintegrate within 1 min when placed in the mouth without drinking water or chewing. Oral drug delivery technology has improved from conventional dosage forms to modified release dosage forms to ODT to the recent oral disintegrating films (ODF). Oral disintegrating film or strip that employs a water dissolving polymer which allows the dosage form to quickly hydrate by saliva, adhere to mucosa, and disintegrate within a few seconds, dissolve and releases medication for oromucosal absorption when placed on the tongue or oral cavity. Oral strip technology provides an alternate route for drugs with first pass metabolism. This review give details of materials used in ODF, manufacturing aspects, technologies, evaluation tests and marketed products.
authors.affiliation: Department of Pharmaceutics, Vaagdevi College of Pharmacy, Warangal, India.
authors.forename: T
authors.initials: T
authors.lastname: Nagaraju
authors.forename: R
authors.initials: R
authors.lastname: Gowthami
authors.forename: M
authors.initials: M
authors.lastname: Rajashekar
authors.forename: S
authors.initials: S
authors.lastname: Sandeep
authors.forename: M
authors.initials: M
authors.lastname: Mallesham
authors.forename: D
authors.initials: D
authors.lastname: Sathish
authors.forename: Y Shravan
authors.initials: YS
authors.lastname: Kumar
mesh_terms: D000284:Administration, Oral; D002626:Chemistry, Pharmaceutical; D004304:Dosage Forms; D016503:Drug Delivery Systems; D004349:Drug Packaging; D004364:Pharmaceutical Preparations / Q000008:administration & dosage; D011786:Quality Control; D012995:Solubility
chemical_list: D004304:Dosage Forms; D004364:Pharmaceutical Preparations