title: Metal cocatalyzed tandem alkynylative cyclization reaction of in situ formed N-iminoisoquinolinium ylides with bromoalkynes via C-H bond activation.
abstract: Silver triflate and copper(I) iodide cocatalyzed direct alkynylation and cyclization reaction of in situ formed N-iminoisoquinolinium ylides with bromoalkynes is described. The reaction proceeds efficiently through a combination of C-H activation and subsequent tandem reaction in one pot, leading to diverse H-pyrazolo[5,1-a]isoquinolines in good yields under mild reaction conditions.
authors.affiliation: Key Laboratory of Functional Small Organic Molecules, Ministry of Education and College of Chemistry & Chemical Engineering, Jiangxi Normal University, Nanchang, Jiangxi 330022, People's Republic of China.
authors.forename: Ping
authors.initials: P
authors.lastname: Huang
authors.forename: Qin
authors.initials: Q
authors.lastname: Yang
authors.forename: Zhiyuan
authors.initials: Z
authors.lastname: Chen
authors.forename: Qiuping
authors.initials: Q
authors.lastname: Ding
authors.forename: Jingshi
authors.initials: J
authors.lastname: Xu
authors.forename: Yiyuan
authors.initials: Y
authors.lastname: Peng
mesh_terms: D000480:Alkynes / Q000737:chemistry*; D002384:Catalysis; D003300:Copper / Q000737:chemistry*; D003500:Cyclization; D006842:Hydrocarbons, Brominated / Q000737:chemistry*; D006860:Hydrogen Bonding; D007546:Isoquinolines / Q000737:chemistry*; D008670:Metals / Q000737:chemistry*; D015394:Molecular Structure; D012834:Silver / Q000737:chemistry*
chemical_list: D000480:Alkynes; D006842:Hydrocarbons, Brominated; D007546:Isoquinolines; D008670:Metals; D012834:Silver; D003300:Copper