title: Optical coherence tomography in retinitis pigmentosa: reproducibility and capacity to detect macular and retinal nerve fiber layer thickness alterations.
abstract: OBJECTIVE
  To evaluate the ability of time-domain and Fourier-domain optical coherence tomographies (OCTs) to detect macular and retinal nerve fiber layer atrophies in retinitis pigmentosa (RP). To test the intrasession reproducibility using three OCT instruments (Stratus, Cirrus, and Spectralis).
  
  
  METHODS
  Eighty eyes of 80 subjects (40 RP patients and 40 healthy subjects) underwent a visual field examination, together with 3 macular scans and 3 optic disk evaluations by the same experienced examiner using 3 OCT instruments. Differences between healthy and RP eyes were compared. The relationship between measurements with each OCT instrument was evaluated. Repeatability was studied by intraclass correlation coefficients and coefficients of variation.
  
  
  RESULTS
  Macular and retinal nerve fiber layer atrophies were detected in RP patients for all OCT parameters. Macular and retinal nerve fiber layer thicknesses, as determined by the different OCTs, were correlated but significantly different (P < 0.05). Reproducibility was moderately high using Stratus, good using Cirrus and Spectralis, and excellent using the Tru-track technology of Spectralis. In RP eyes, measurements showed higher variability compared with healthy eyes.
  
  
  CONCLUSIONS
  Differences in thickness measurements existed between OCT instruments, despite there being a high degree of correlation. Fourier-domain OCT can be considered a valid and repeatability technique to detect retinal nerve fiber layer atrophy in RP patients.
authors.affiliation: Department of Ophthalmology, Miguel Servet University Hospital, Zaragoza, Spain. egmvivax@yahoo.com
authors.forename: Elena
authors.initials: E
authors.lastname: Garcia-Martin
authors.forename: Isabel
authors.initials: I
authors.lastname: Pinilla
authors.forename: Eva
authors.initials: E
authors.lastname: Sancho
authors.forename: Carmen
authors.initials: C
authors.lastname: Almarcegui
authors.forename: Isabel
authors.initials: I
authors.lastname: Dolz
authors.forename: Diego
authors.initials: D
authors.lastname: Rodriguez-Mena
authors.forename: Isabel
authors.initials: I
authors.lastname: Fuertes
authors.forename: Nicolas
authors.initials: N
authors.lastname: Cuenca
mesh_terms: D000328:Adult; D000368:Aged; D003430:Cross-Sectional Studies; D005260:Female; D005583:Fourier Analysis; D006801:Humans; D008266:Macula Lutea / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D009412:Nerve Fibers / Q000473:pathology*; D009929:Organ Size; D011446:Prospective Studies; D015203:Reproducibility of Results; D012165:Retinal Ganglion Cells / Q000473:pathology*; D012174:Retinitis Pigmentosa / Q000175:diagnosis*; D013997:Time Factors; D041623:Tomography, Optical Coherence / Q000295:instrumentation* / Q000592:standards; D014792:Visual Acuity / Q000502:physiology