title: Late recurrence of sigmoid carcinoma mimicking primary vulvar cancer: case report and review of the literature.
abstract: OBJECTIVE
  To demonstrate a unique case report about late and isolated vulvar metastasis of sigmoid adeno-carcinoma with review of the literature.
  
  
  METHODS
  57 year old postmenopausal patient with prior sigmoid colon cancer history was admitted with isolated vulvar mass. Immunohistochemistry (IHC) and KRAS gen mutation analysis following surgery were performed to discriminate the metastasis from a vulvar primary malignancy. Further imaging techniques were also performed to exclude additional tumours.
  
  
  RESULTS
  Immunohistochemistry (IHC) and KRAS gene mutation analysis revealed isolated metastasis of the colonic adeno-carcinoma in the vulva.
  
  
  CONCLUSIONS
  Isolated and late occurring vulvar metastasis of colonic origin is very unusual. Careful evaluation and IHC is useful for such cases.
authors.affiliation: Ankara University School of Medicine, Department of Obstetrics and Gynecology, Ankara, Turkey. pabuccu@hotmail.com
authors.forename: Emre
authors.initials: E
authors.lastname: Pabuccu
authors.forename: Harun Egemen
authors.initials: HE
authors.lastname: Tolunay
authors.forename: Evren
authors.initials: E
authors.lastname: Kocbulut
authors.forename: Salih
authors.initials: S
authors.lastname: Taskın
authors.forename: Fırat
authors.initials: F
authors.lastname: Ortac
authors.forename: Ayse
authors.initials: A
authors.lastname: Sertcelik
authors.forename: Aysegul
authors.initials: A
authors.lastname: Sasmaz
authors.forename: Berna
authors.initials: B
authors.lastname: Savas
mesh_terms: D000230:Adenocarcinoma / Q000235:genetics / Q000378:metabolism / Q000556:secondary*; D014408:Biomarkers, Tumor / Q000235:genetics / Q000378:metabolism; D004252:DNA Mutational Analysis; D004273:DNA, Neoplasm; D005260:Female; D006801:Humans; D008875:Middle Aged; D009154:Mutation; D009364:Neoplasm Recurrence, Local / Q000175:diagnosis*; D011518:Proto-Oncogene Proteins / Q000235:genetics / Q000378:metabolism; D016283:Proto-Oncogene Proteins p21(ras); D012811:Sigmoid Neoplasms / Q000235:genetics / Q000378:metabolism / Q000473:pathology*; D014846:Vulvar Neoplasms / Q000235:genetics / Q000378:metabolism / Q000556:secondary*; D018631:ras Proteins / Q000235:genetics / Q000378:metabolism
chemical_list: D014408:Biomarkers, Tumor; D004273:DNA, Neoplasm; C117307:KRAS protein, human; D011518:Proto-Oncogene Proteins; D016283:Proto-Oncogene Proteins p21(ras); D018631:ras Proteins