title: Mammary carcinoma in a tiger (Panthera tigris): morphological and immunohistochemical study.
abstract: The histologic and immunohistochemical features of a case of mammary gland carcinoma are described in a 14-yr-old female tiger (Panthera tigris). Immunoreactivity to estrogen receptor (ER), progesterone receptor (PR), tumoral protein 53 (p53), vascular endothelial growth factor (VEGF), human epidermal growth factor receptor 2 (HER-2), and cyclooxigenase-2 (COX-2) was investigated. Neoplastic cells were negative for ER, PR, and p53 but showed positivity for VEGF, HER-2, and COX-2, both in the primary and the metastatic lesions. Histopathologic findings and immunohistochemistry results suggested that the malignant behavior of the reported case could be comparable with some aggressive cat mammary carcinomas.
authors.affiliation: Department of Animal Pathology, Faculty of Veterinary Medicine, Viale delle Piagge 2, 56124 Pisa, Italy. finotello@vet.unipi.it
authors.forename: Riccardo
authors.initials: R
authors.lastname: Finotello
authors.forename: Lorenzo
authors.initials: L
authors.lastname: Ressel
authors.forename: Ranieri
authors.initials: R
authors.lastname: Verin
authors.forename: Simonetta
authors.initials: S
authors.lastname: Di Lollo
authors.forename: Gianna
authors.initials: G
authors.lastname: Baroni
authors.forename: Renato
authors.initials: R
authors.lastname: Piccinini
authors.forename: Alessandro
authors.initials: A
authors.lastname: Poli
mesh_terms: D000818:Animals; D002277:Carcinoma / Q000473:pathology / Q000662:veterinary*; D051546:Cyclooxygenase 2 / Q000235:genetics / Q000378:metabolism; D017809:Fatal Outcome; D005260:Female; D015972:Gene Expression Regulation, Neoplastic / Q000502:physiology; D007150:Immunohistochemistry / Q000662:veterinary*; D015674:Mammary Neoplasms, Animal / Q000473:pathology*; D018719:Erb-b2 Receptor Tyrosine Kinases / Q000235:genetics / Q000378:metabolism; D042461:Vascular Endothelial Growth Factor A / Q000235:genetics / Q000378:metabolism
chemical_list: D051546:Cyclooxygenase 2; D018719:Erb-b2 Receptor Tyrosine Kinases; D042461:Vascular Endothelial Growth Factor A