title: Plant genome-scale metabolic reconstruction and modelling.
abstract: Genome-scale metabolic reconstructions are used extensively in the study of microbial metabolism and have proven powerful tools to guide rational pathway design of industrial strains. Generation and curation of plant genome-scale metabolic models has proven far more challenging, not the least of which is our incomplete knowledge of compartmentation and organelle transporters in plants. Conversely, the potential value of modelling is far greater when exploring a complex, multi-organelle and multi-tissue metabolism. The first generation of plant genome-scale metabolic reconstructions have proven surprisingly functional and robust as well as capable of predicting many observed complex phenotypes. With further refinement, the application of these models promises to make important contributions to plant biology and metabolic engineering.
authors.affiliation: Australian Institute for Bioengineering and Nanotechnology, University of Queensland, Brisbane, Queensland 4072, Australia.
authors.forename: Cristiana Gomes
authors.initials: CG
authors.lastname: de Oliveira Dal'Molin
authors.forename: Lars Keld
authors.initials: LK
authors.lastname: Nielsen
mesh_terms: D017360:Arabidopsis / Q000235:genetics / Q000378:metabolism; D002451:Cell Compartmentation; D018745:Genome, Plant / Q000235:genetics*; D060847:Metabolic Engineering; D053858:Metabolic Networks and Pathways / Q000235:genetics*; D008954:Models, Biological; D058977:Molecular Sequence Annotation; D010944:Plants / Q000235:genetics* / Q000378:metabolism*