title: [Predictive value of corrected QT interval, corrected Tp-e interval and Tp-e/QT ratio on malignant arrhythmia events in acute ST-segment elevation myocardial infarction patients undergoing thrombolysis].
abstract: OBJECTIVE
  The prognostic value of corrected QT interval (QTc), corrected Tp-e interval (Tp-ec) and Tp-e/QT ratio on occurrence of malignant arrhythmia events (MAE) in acute ST-segment elevation myocardial infarction (STEMI) patients underwent successful thrombolysis was explored and the potential association of these indices with MAE was analyzed.
  
  
  METHODS
  Fifty-seven STEMI patients underwent successful thrombolytic therapy within 6 hours after admission and conservative medical treatment were included. QTc, Tp-ec, Tp-e/QT ratio were obtained and calculated in infarct-related electrocardiograph leads and non-infarct-related leads before thrombolysis, (7±1) days and (30±3) days after thrombolysis respectively, and incidence of MAE up to 30 days after thrombolysis was analyzed. Sixty age and gender matched normal subjects served as control group.
  
  
  RESULTS
  (1) QTc, Tp-ec, Tp-e/QT in infarct-related and non-infarct-related leads in STEMI group before thrombolysis were significantly higher than those in control group (all P<0.05), and values from the infarct-related leads were significantly higher than those from non-infarct-related leads in STEMI group (all P<0.05). QTc, Tp-ec and Tp-e/QT all significantly and continuously reduced from 7 days and at 30 days post thrombolysis compared the before thrombolysis (P<0.05 vs. before thrombolysis). (2) Tp-ec≥100 ms and Tp-e/QT ratio≥0.25 before thrombolysis in infarct-related leads were linked with higher incidence of MAE within 30 days post thrombolysis in this patient cohort [28.1% (9/32) vs. 40% (1/25), 27.8% (10/36) vs.0, respectively, all P<0.05].
  
  
  CONCLUSIONS
  QTc, Tp-ec and Tp-e/QT values decreased post successful thrombolysis in STEMI patients and higher Tp-ec and Tp-e/QT values before thrombolysis in STEMI patients were related with higher MAE incidence up to 30 days post successful thrombolysis in this patient cohort.
authors.affiliation: Department of Cardiology, People's Hospital of Zhengzhou University, Institute of Cardiovascnlar Epidemiology of Henan Province, Zhengzhou 450003, China.
authors.forename: Wen-tao
authors.initials: WT
authors.lastname: Xiao
authors.forename: Xian-pei
authors.initials: XP
authors.lastname: Wang
authors.forename: Chuan-yu
authors.initials: CY
authors.lastname: Gao
authors.forename: Juan-juan
authors.initials: JJ
authors.lastname: Yan
authors.forename: Mu-wei
authors.initials: MW
authors.lastname: Li
authors.forename: You
authors.initials: Y
authors.lastname: Zhang
authors.forename: Jing-jing
authors.initials: JJ
authors.lastname: Liu
mesh_terms: D000368:Aged; D004562:Electrocardiography / Q000379:methods*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000188:drug therapy* / Q000503:physiopathology*; D015912:Thrombolytic Therapy; D016896:Treatment Outcome