title: [Candida glabrata : pathogenicity and therapy update].
abstract: Chronic recurrent vulvovaginal candidiasis caused by Candida glabrata is still rare in comparison to C. albicans infection, but therapy remains more difficult. Standard agents as fluconazole or itraconazole often fail, as well as the newer systemic triazoles like voriconazole or posaconazole. Micafungin is a new echinocandin drug with a wide antifungal spectrum including rare Candida species. No clinical trials with micafungin in chronic recurrent vulvovaginal candidiasis have been undertaken. We present the initial results employing a new therapy regimen consisting of micafungin in combination with topical ciclopirox olamine. All 14 patients with chronic recurrent vulvovaginal candidiasis caused by C. glabrata were treated successfully.
authors.affiliation: Institut für Pilzkrankheiten und Mikrobiologie, Luisenstr. 50, 10117, Berlin, Deutschland. tietz@institut-fuer-pilzkrankheiten.de
authors.forename: H-J
authors.initials: HJ
authors.lastname: Tietz
mesh_terms: D000287:Administration, Topical; D000935:Antifungal Agents / Q000008:administration & dosage; D041221:Candida glabrata / Q000187:drug effects / Q000472:pathogenicity*; D002179:Candidiasis, Cutaneous / Q000175:diagnosis / Q000188:drug therapy* / Q000382:microbiology*; D002181:Candidiasis, Vulvovaginal / Q000175:diagnosis / Q000188:drug therapy* / Q000382:microbiology*; D000077768:Ciclopirox; D004359:Drug Therapy, Combination; D054714:Echinocandins / Q000008:administration & dosage*; D005260:Female; D006801:Humans; D055666:Lipopeptides / Q000008:administration & dosage*; D000077551:Micafungin; D011728:Pyridones / Q000008:administration & dosage*; D016896:Treatment Outcome
chemical_list: D000935:Antifungal Agents; D054714:Echinocandins; D055666:Lipopeptides; D011728:Pyridones; D000077768:Ciclopirox; D000077551:Micafungin