title: BCG protects against tuberculosis irrespective of HIV status: a matched case-control study in Mwanza, Tanzania.
abstract: While BCG vaccine protects against severe tuberculosis (TB) in children, its effect against adult TB is questionable. Furthermore, it is not known if HIV co-infection modifies the effect of BCG. Among 352 pairs of Tanzanian TB cases and matched controls, the BCG scar was associated with a reduced risk of TB (OR 0.3, 95% CI 0.2 to 0.7, p=0.005), irrespective of HIV status (interaction, p=0.623). BCG vaccination considerably reduced the risk of TB, both among individuals with and without HIV infection.
authors.forename: Daniel
authors.initials: D
authors.lastname: Faurholt-Jepsen
authors.forename: Nyagosya
authors.initials: N
authors.lastname: Range
authors.forename: George
authors.initials: G
authors.lastname: Praygod
authors.forename: Kidola
authors.initials: K
authors.lastname: Jeremiah
authors.forename: Maria
authors.initials: M
authors.lastname: Faurholt-Jepsen
authors.forename: Martine G
authors.initials: MG
authors.lastname: Aabye
authors.forename: Harleen M S
authors.initials: HM
authors.lastname: Grewal
authors.forename: John
authors.initials: J
authors.lastname: Changalucha
authors.forename: Daniel R
authors.initials: DR
authors.lastname: Witte
authors.forename: Aase B
authors.initials: AB
authors.lastname: Andersen
authors.forename: Henrik
authors.initials: H
authors.lastname: Friis
mesh_terms: D000328:Adult; D000428:Alcohol Drinking; D001500:BCG Vaccine; D016022:Case-Control Studies; D002921:Cicatrix / Q000276:immunology; D016001:Confidence Intervals; D015658:HIV Infections / Q000150:complications*; D018023:HIV Seronegativity; D006801:Humans; D016015:Logistic Models; D015999:Multivariate Analysis; D016017:Odds Ratio; D012307:Risk Factors; D012907:Smoking; D013636:Tanzania; D014397:Tuberculosis, Pulmonary / Q000517:prevention & control*
chemical_list: D001500:BCG Vaccine