title: Biodegradable polymer based encapsulation of neem oil nanoemulsion for controlled release of Aza-A.
abstract: Azadirachtin a biological compound found in neem have medicinal and pesticidal properties. The present work reports on the encapsulation of neem oil nanoemulsion using sodium alginate (Na-Alg) by cross linking with glutaraldehyde. Starch and polyethylene glycol (PEG) were used as coating agents for smooth surface of beads. The SEM images showed beads exhibited nearly spherical shape. Swelling of the polymeric beads reduced with coating which in turn decreased the rate of release of Aza-A. Starch coated encapsulation of neem oil nanoemulsion was found to be effective when compared to PEG coated encapsulation of neem oil nanoemulsion. The release rate of neem Aza-A from the beads into an aqueous environment was analyzed by UV-visible spectrophotometer (214 nm). The encapsulated neem oil nanoemulsion have the potential for controlled release of Aza-A. Neem oil nanoemulsion encapsulated beads coated with PEG was found to be toxic in lymphocyte cells.
authors.affiliation: Centre for Nanobiotechnology, VIT University, Vellore 632014, India.
authors.forename: Jayakumar
authors.initials: J
authors.lastname: Jerobin
authors.forename: R S
authors.initials: RS
authors.lastname: Sureshkumar
authors.forename: C H
authors.initials: CH
authors.lastname: Anjali
authors.forename: Amitava
authors.initials: A
authors.lastname: Mukherjee
authors.forename: Natarajan
authors.initials: N
authors.lastname: Chandrasekaran
mesh_terms: D000464:Alginates / Q000737:chemistry*; D031601:Azadirachta / Q000737:chemistry; D002478:Cells, Cultured; D003432:Cross-Linking Reagents / Q000737:chemistry*; D004655:Emulsions; D020723:Glucuronic Acid / Q000737:chemistry; D005976:Glutaral / Q000737:chemistry; D005989:Glycerides / Q000737:chemistry*; D006603:Hexuronic Acids / Q000737:chemistry; D006801:Humans; D007306:Insecticides / Q000378:metabolism; D036701:Limonins / Q000378:metabolism*; D008214:Lymphocytes / Q000187:drug effects* / Q000473:pathology; D008855:Microscopy, Electron, Scanning; D008863:Microspheres; D011092:Polyethylene Glycols / Q000737:chemistry*; D011108:Polymers / Q000737:chemistry*; D017550:Spectroscopy, Fourier Transform Infrared; D013729:Terpenes / Q000737:chemistry*
chemical_list: D000464:Alginates; D003432:Cross-Linking Reagents; D004655:Emulsions; D005989:Glycerides; D006603:Hexuronic Acids; D007306:Insecticides; D036701:Limonins; D011108:Polymers; D013729:Terpenes; D011092:Polyethylene Glycols; C002443:neem oil; D020723:Glucuronic Acid; C010329:azadirachtin; D005976:Glutaral