title: Otitis media and otomastoiditis caused by Mycobacterium massiliense (Mycobacterium abscessus subsp. bolletii).
abstract: We describe two patients with otologic infections caused by Mycobacterium massiliense (M. abscessus subsp. bolletti) which were identified using erm(41) PCR, 23S rRNA, and rpoB gene sequence analysis. They were middle-aged adults with underlying otologic diseases and were treated successfully with clarithromycin-based combination regimens for 3 and 9 months, respectively.
authors.affiliation: Department of Internal Medicine, Taoyuan General Hospital, Taoyuan County, Taiwan.
authors.forename: Meng-Rui
authors.initials: MR
authors.lastname: Lee
authors.forename: Hsih-Yeh
authors.initials: HY
authors.lastname: Tsai
authors.forename: Aristine
authors.initials: A
authors.lastname: Cheng
authors.forename: Chia-Ying
authors.initials: CY
authors.lastname: Liu
authors.forename: Yu-Tsung
authors.initials: YT
authors.lastname: Huang
authors.forename: Chun-Hsing
authors.initials: CH
authors.lastname: Liao
authors.forename: Sheng-Kai
authors.initials: SK
authors.lastname: Liang
authors.forename: Li-Na
authors.initials: LN
authors.lastname: Lee
authors.forename: Po-Ren
authors.initials: PR
authors.lastname: Hsueh
mesh_terms: D000900:Anti-Bacterial Agents / Q000008:administration & dosage; D017291:Clarithromycin / Q000008:administration & dosage; D004269:DNA, Bacterial / Q000737:chemistry / Q000235:genetics; D004275:DNA, Ribosomal / Q000737:chemistry / Q000235:genetics; D012321:DNA-Directed RNA Polymerases / Q000235:genetics; D004359:Drug Therapy, Combination / Q000379:methods; D006801:Humans; D008297:Male; D008417:Mastoiditis / Q000188:drug therapy / Q000382:microbiology*; D008780:Methyltransferases / Q000235:genetics; D008826:Microbial Sensitivity Tests; D008875:Middle Aged; D009161:Mycobacterium / Q000145:classification / Q000187:drug effects / Q000235:genetics / Q000302:isolation & purification*; D009164:Mycobacterium Infections / Q000175:diagnosis* / Q000188:drug therapy / Q000382:microbiology; D010033:Otitis Media / Q000188:drug therapy / Q000382:microbiology*; D012338:RNA, Ribosomal, 23S / Q000235:genetics; D017422:Sequence Analysis, DNA; D016896:Treatment Outcome
chemical_list: D000900:Anti-Bacterial Agents; D004269:DNA, Bacterial; D004275:DNA, Ribosomal; D012338:RNA, Ribosomal, 23S; D008780:Methyltransferases; D012321:DNA-Directed RNA Polymerases; C105078:RNA polymerase beta subunit; D017291:Clarithromycin