title: Correlation of photographic images from the Leeds revised acne grading system with a six-category global acne severity scale.
abstract: BACKGROUND
  Few global acne grading systems include individualized assessments of chest and back as well as face. The Leeds revised acne grading system is based on photographic images while the Comprehensive Acne Severity Scale (CASS) is based on textual descriptions. There exists an unmet need for a global scale based on both text and photos.
  
  
  OBJECTIVE
  Our objective was to evaluate the correspondence of severity grades from descriptive text (CASS grades) for each Leeds image.
  
  
  METHODS
  Twenty-three dermatologists independently graded 56 photos of face, chest and back of varying acne severity using CASS. Photographs were randomly presented from the The Leeds revised acne grading system (n = 31) and from acne patients of the corresponding author (n = 25). For each Leeds photo, rater responses for CASS grades were transformed into median, coefficient of variation and percentiles.
  
  
  RESULTS
  High rater agreement (≥75%) was observed for Leeds facial inflammatory 2 (CASS 3), 4 (CASS 4), 6 (CASS 4), 9-12 (all CASS 5); Leeds facial comedonal A (CASS 2); Leeds chest 7 and 8 (both CASS 5); and Leeds back 7 and 8 (both CASS 5). Lowest coefficients of variance were observed in Leeds facial inflammatory 4, 9, 10, 11; Leeds facial comedonal A; Leeds chest 7 and 8; and Leeds back 8. Conclusions Leeds photos, by inadequately portraying facial acne grades 1 (almost clear) and 2 (mild) and back and chest grades 1-4 (almost clear to severe), cannot accurately represent the spectrum of severity in a six-category global acne scale. Accordingly, there is a current need for images that correspond to a categorical acne scale.
authors.affiliation: University of Western Ontario and Windsor Clinical Research Inc., Deptartment of Mathematics and Statistics, University of Windsor, Windsor, Ontario Windsor Program, Schulich School of Medicine and Dentistry, University of Western Ontario, Ontario, Canada Director of Medical Affairs, Stiefel Laboratories, Montreal, Quebec, Canada.
authors.forename: J K L
authors.initials: JK
authors.lastname: Tan
authors.forename: X
authors.initials: X
authors.lastname: Zhang
authors.forename: E
authors.initials: E
authors.lastname: Jones
authors.forename: L
authors.initials: L
authors.lastname: Bulger
mesh_terms: D000152:Acne Vulgaris / Q000473:pathology*; D003880:Dermatology; D006801:Humans; D010781:Photography; D012720:Severity of Illness Index; D000078329:Workforce