title: Effects of Ginkgo biloba on experimental rapid maxillary expansion model: a histomorphometric study.
abstract: OBJECTIVE
  We aimed to investigate the effect of systemic Ginkgo biloba in rapid maxillary expansion (RME).
  
  
  METHODS
  We randomly divided 24 rats into 3 groups: expansion only (EO), expansion plus Ginkgo biloba (GB), and no expansion (NE). Expansion appliances were affixed to the maxillary incisors. After a 5-day expansion period, there was a consolidation period of 15 days, following which the rats were killed. Histomorphometric examination was performed to determine the number of osteoclasts, osteoblasts, and capillaries, the number and intensity of inflammatory cells, and new bone formation.
  
  
  RESULTS
  New bone formation, number of capillaries, and the ratio of inflammatory cells in maxillary sutures were higher in the GB group than in the other groups. Statistical analysis demonstrated that the GB group had more osteoblasts and osteoclasts than the other groups.
  
  
  CONCLUSIONS
  GB may hasten new bone regeneration in RME and prevent relapse after RME.
authors.affiliation: Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Izmir Katip Celebi University, Izmir, Turkey. phismer@yahoo.com
authors.forename: Muhammed Isa
authors.initials: MI
authors.lastname: Kara
authors.forename: Ayşe Burcu
authors.initials: AB
authors.lastname: Altan
authors.forename: Ufuk
authors.initials: U
authors.lastname: Sezer
authors.forename: Muharrem Şerif
authors.initials: MŞ
authors.lastname: Erdoğan
authors.forename: Sevinc
authors.initials: S
authors.lastname: Inan
authors.forename: Mahmud
authors.initials: M
authors.lastname: Ozkut
authors.forename: Ruhi
authors.initials: R
authors.lastname: Nalcacı
mesh_terms: D000818:Animals; D020441:Ginkgo biloba; D008297:Male; D023421:Models, Animal; D010155:Palatal Expansion Technique; D051381:Rats; D017208:Rats, Wistar