title: Two new sesquiterpene derivatives from Chinese eaglewood.
abstract: Two new sesquiterpene derivatives, (+)-8β-hydroxy-longicamphenylone (1) and 11β-hydroxy-13-isopropyl-dihydrodehydrocostus lactone (2), were isolated from Chinese eaglewood. Their structures were elucidated on the basis of spectroscopic analyses including HR-ESI-MS, (1)H and (13)C NMR, DEPT, (1)H-(1)H COSY, HSQC, HMBC, and NOE. The two compounds exhibited potent anti-depressant activity in vitro by inhibiting [(3)H]-5-HT reuptake in rat brain synaptosomes by 54.8% and 51.9%, respectively, at 10 μM.
authors.affiliation: College of Life and Environmental Sciences, Minzu University of China, Beijing 100081, China.
authors.forename: Lin
authors.initials: L
authors.lastname: Yang
authors.forename: Li-Rui
authors.initials: LR
authors.lastname: Qiao
authors.forename: Jian-Jun
authors.initials: JJ
authors.lastname: Zhang
authors.forename: Jun-Gui
authors.initials: JG
authors.lastname: Dai
authors.forename: Shun-Xing
authors.initials: SX
authors.lastname: Guo
mesh_terms: D000818:Animals; D000928:Antidepressive Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D019659:Asteraceae / Q000737:chemistry*; D001921:Brain / Q000187:drug effects; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D007783:Lactones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D015394:Molecular Structure; D051381:Rats; D017367:Selective Serotonin Reuptake Inhibitors / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D012717:Sesquiterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D029645:Thymelaeaceae / Q000737:chemistry*
chemical_list: D000928:Antidepressive Agents; D004365:Drugs, Chinese Herbal; D007783:Lactones; D017367:Selective Serotonin Reuptake Inhibitors; D012717:Sesquiterpenes; C578649:11beta-hydroxy-13-isopropyl-dihydrodehydrocostus lactone; C578648:8beta-hydroxy-longicamphenylone