title: Optimization of [11C]DASB-synthesis: vessel-based and flow-through microreactor methods.
abstract: The intention for the present study was to implement a microfluidic set-up for N-(11)C-methylations in a flow-through microreactor device with [(11)C]DASB as model-compound and [(11)C]CH(3)I and [(11)C]CH(3)OTf, respectively, as (11)C-methylation agents. Due to an observed "aging" effect of the (11)C-methylation agents' solution, this goal was not achieved. Nevertheless, based on these observations, the time consumption for the vessel-based routine production of [(11)C]DASB was reduced (34±1 min) and RCY was increased to 45.1±4.6% (EOB; 5.2±0.95 GBq EOS).
authors.affiliation: Radiochemistry and Biomarker Development Unit, Department of Nuclear Medicine, Medical University of Vienna, Waehringer Guertel 18-20, A-1090 Vienna, Austria.
authors.forename: Johanna
authors.initials: J
authors.lastname: Ungersboeck
authors.forename: Cecile
authors.initials: C
authors.lastname: Philippe
authors.forename: Daniela
authors.initials: D
authors.lastname: Haeusler
authors.forename: Markus
authors.initials: M
authors.lastname: Mitterhauser
authors.forename: Rupert
authors.initials: R
authors.lastname: Lanzenberger
authors.forename: Robert
authors.initials: R
authors.lastname: Dudczak
authors.forename: Wolfgang
authors.initials: W
authors.lastname: Wadsak
mesh_terms: D000814:Aniline Compounds / Q000138:chemical synthesis*; D002250:Carbon Radioisotopes; D007553:Isotope Labeling / Q000379:methods; D008745:Methylation; D044085:Microfluidics / Q000379:methods*; D009570:Nitriles / Q000138:chemical synthesis*; D049268:Positron-Emission Tomography; D019275:Radiopharmaceuticals / Q000138:chemical synthesis*; D013440:Sulfides / Q000138:chemical synthesis*
chemical_list: C412822:3-amino-4-(2-dimethylaminomethylphenylsulfanyl)benzonitrile; D000814:Aniline Compounds; D002250:Carbon Radioisotopes; D009570:Nitriles; D019275:Radiopharmaceuticals; D013440:Sulfides; C014356:benzonitrile