title: Minute type I gastric carcinoid with regional lymph node metastasis.
abstract: Type I gastric carcinoids are indolent lesions that only rarely metastasize. Until now, lymph node metastasis had only being observed in large (≥10 mm) and usually invasive lesions (deep submucosa or beyond). This study reports a diminutive (8 mm) gastric carcinoid, limited to the superficial layer of the submucosa (sm1), with no angiovascular invasion, but with a high Ki-67 index (7%) and an involved perigastric lymph node. The aggressive behavior of this lesion ends the previous believe that small and superficial type I gastric carcinoids do not metastasize. This case also indicates that better parameters are necessary to evaluate the malignant potential of these lesions and presents a further support to the value of 2010 World Health Organization classification of gastrointestinal neuroendocrine tumors.
authors.affiliation: Hospital do Servidor Estadual, Sao Paulo, Brazil.
authors.forename: Renato Micelli
authors.initials: RM
authors.lastname: Lupinacci
authors.forename: André Roncon
authors.initials: AR
authors.lastname: Dias
authors.forename: Evandro Sobroza
authors.initials: ES
authors.lastname: Mello
authors.forename: André
authors.initials: A
authors.lastname: Kondo
mesh_terms: D002276:Carcinoid Tumor / Q000378:metabolism / Q000503:physiopathology / Q000556:secondary*; D006801:Humans; D008207:Lymphatic Metastasis / Q000473:pathology; D008297:Male; D008875:Middle Aged; D013274:Stomach Neoplasms / Q000378:metabolism / Q000473:pathology* / Q000503:physiopathology