title: Subjective cognitive complaints and amyloid burden in cognitively normal older individuals.
abstract: Accumulating evidence suggests that subjective cognitive complaints (SCC) may indicate subtle cognitive decline characteristic of individuals with preclinical Alzheimer's disease (AD). In this study, we sought to build upon previous studies by associating SCC and amyloid-β deposition using positron emission tomography with Pittsburgh Compound B (PiB-PET) in cognitively normal older individuals. One-hundred thirty one subjects (mean age 73.5±6) were administered three subjective cognitive questionnaires and a brief neuropsychological battery. A relationship between a subjective memory complaints composite score and cortical PiB binding was found to be significant, even after controlling for depressive symptoms. By contrast, there were no significant relationships between objective cognitive measures of memory and executive functions and cortical PiB binding. Our study suggests that SCC may be an early indicator of AD pathology detectable prior to significant objective impairment.
authors.affiliation: Department of Neurology, Division of Cognitive and Behavioral Neurology, Brigham and Women's Hospital, 221 Longwood Avenue, Boston, MA 02115, United States; Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, United States. Electronic address: ramariglio@partners.org.
authors.forename: Rebecca E
authors.initials: RE
authors.lastname: Amariglio
authors.affiliation: Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, United States.
authors.forename: J Alex
authors.initials: JA
authors.lastname: Becker
authors.affiliation: Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, United States.
authors.forename: Jeremy
authors.initials: J
authors.lastname: Carmasin
authors.affiliation: Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, United States.
authors.forename: Lauren P
authors.initials: LP
authors.lastname: Wadsworth
authors.affiliation: Department of Neurology, Division of Cognitive and Behavioral Neurology, Brigham and Women's Hospital, 221 Longwood Avenue, Boston, MA 02115, United States; Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, United States.
authors.forename: Natacha
authors.initials: N
authors.lastname: Lorius
authors.affiliation: Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, United States.
authors.forename: Caroline
authors.initials: C
authors.lastname: Sullivan
authors.affiliation: Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, United States.
authors.forename: Jacqueline E
authors.initials: JE
authors.lastname: Maye
authors.affiliation: Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, United States.
authors.forename: Christopher
authors.initials: C
authors.lastname: Gidicsin
authors.affiliation: Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, United States.
authors.forename: Lesley C
authors.initials: LC
authors.lastname: Pepin
authors.affiliation: Department of Neurology, Division of Cognitive and Behavioral Neurology, Brigham and Women's Hospital, 221 Longwood Avenue, Boston, MA 02115, United States; Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, United States.
authors.forename: Reisa A
authors.initials: RA
authors.lastname: Sperling
authors.affiliation: Department of Neurology, Division of Cognitive and Behavioral Neurology, Brigham and Women's Hospital, 221 Longwood Avenue, Boston, MA 02115, United States; Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, United States; Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, United States.
authors.forename: Keith A
authors.initials: KA
authors.lastname: Johnson
authors.affiliation: Department of Neurology, Division of Cognitive and Behavioral Neurology, Brigham and Women's Hospital, 221 Longwood Avenue, Boston, MA 02115, United States; Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, United States.
authors.forename: Dorene M
authors.initials: DM
authors.lastname: Rentz
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000378:metabolism / Q000523:psychology; D000544:Alzheimer Disease / Q000378:metabolism / Q000523:psychology; D016229:Amyloid beta-Peptides / Q000378:metabolism*; D000814:Aniline Compounds; D001921:Brain / Q000378:metabolism*; D005260:Female; D006801:Humans; D008297:Male; D009483:Neuropsychological Tests; D049268:Positron-Emission Tomography; D062706:Prodromal Symptoms; D019275:Radiopharmaceuticals; D013844:Thiazoles
chemical_list: C475519:2-(4'-(methylamino)phenyl)-6-hydroxybenzothiazole; D016229:Amyloid beta-Peptides; D000814:Aniline Compounds; D019275:Radiopharmaceuticals; D013844:Thiazoles