title: Characterization of natural killer cells in paired CSF and blood samples during neuroinflammation.
abstract: Natural killer (NK) cells from paired CSF and blood samples of patients with multiple sclerosis (MS), other neuroinflammatory diseases (IND), and non-inflammatory neurological diseases (NIND) were characterized using flow cytometry. NK cell frequency in CSF was overall decreased compared to blood, particularly in MS patients. In contrast to blood NK cells, during neuroinflammation, CSF NK cells display an immature phenotype with bright expression of CD56 and CD27 and reduced CX3CR1 expression. Our findings suggest that, as for central memory T cells, CSF may represent an intermediary compartment for NK cell trafficking and differentiation before entering the CNS parenchyma.
authors.affiliation: Experimental and Clinical Research Center, Charité-Universitätsmedizin Berlin and Max-Delbrück Center for Molecular Medicine, Berlin, Germany.
authors.forename: Isabell
authors.initials: I
authors.lastname: Hamann
authors.forename: Jan
authors.initials: J
authors.lastname: Dörr
authors.forename: Robert
authors.initials: R
authors.lastname: Glumm
authors.forename: Coralie
authors.initials: C
authors.lastname: Chanvillard
authors.forename: Antonia
authors.initials: A
authors.lastname: Janssen
authors.forename: Jason M
authors.initials: JM
authors.lastname: Millward
authors.forename: Friedemann
authors.initials: F
authors.lastname: Paul
authors.forename: Richard M
authors.initials: RM
authors.lastname: Ransohoff
authors.forename: Carmen
authors.initials: C
authors.lastname: Infante-Duarte
mesh_terms: D000328:Adult; D015703:Antigens, CD / Q000378:metabolism; D004660:Encephalitis / Q000097:blood / Q000134:cerebrospinal fluid / Q000473:pathology; D005260:Female; D005434:Flow Cytometry; D006801:Humans; D007694:Killer Cells, Natural / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000097:blood / Q000134:cerebrospinal fluid / Q000473:pathology; D013601:T-Lymphocytes / Q000473:pathology; D055815:Young Adult
chemical_list: D015703:Antigens, CD