title: [Endothelial dysfunction in type 2 diabetic patients with normal coronary arteries. A peripheral arterial tonometry study].
abstract: OBJECTIVE
  to evaluate endothelial function (EF) in diabetic and non-diabetic patients without CAD by peripheral artery tonometry (PAT) technique.
  
  
  METHODS
  a cohort of 94 patients (55 men and 39 postmenopausal women; mean age 63 +/- 9 years) undergoing coronary angiography was divided into 2 groups: 58 patients with DM and (group 1) and 36 patients without DM. Endothelial dysfunction (ED) was assessed by digital pulse amplitude, using a fingertip peripheral arterial tonometry (PAT). As a measure of ED, reactive hyperemia index (RHI) was calculated as the ratio of the digital pulse volume during reactive hyperemia following 5 min ischemia and its basal value.
  
  
  RESULTS
  prevalence of cardiovascular risk factors was similar between the two groups. RHI values were significantly lower in diabetic patients compared to non-diabetics (1.72 +/- 0.34 vs 2.00 +/- 0.44; p < 0.005) and they correlated with levels of glycosylated hemoglobin (p = 0.05; r = -0.266).
  
  
  CONCLUSIONS
  despite similar level of other risk factors, EF was much more impaired in diabetic patients than in non-diabetics. These evidences further support the impact of DM on cardiovascular risk.
authors.affiliation: Dipartimento di Medicina Interna, Scienze Cardiovascolari ed Immunologiche, Università degli Studi di Napoli Federico II.
authors.forename: Donatella
authors.initials: D
authors.lastname: Ruggiero
authors.forename: Gianluigi
authors.initials: G
authors.lastname: Savarese
authors.forename: Roberto
authors.initials: R
authors.lastname: Formisano
authors.forename: Ada
authors.initials: A
authors.lastname: Bologna
authors.forename: Giacomo
authors.initials: G
authors.lastname: Mattiello
authors.forename: Elisabetta
authors.initials: E
authors.lastname: Pirozzi
authors.forename: Francesco
authors.initials: F
authors.lastname: Gambardella
authors.forename: Francesco
authors.initials: F
authors.lastname: Lo Iudice
authors.forename: Laura
authors.initials: L
authors.lastname: Petraglia
authors.forename: Alice
authors.initials: A
authors.lastname: Vitagliano
authors.forename: Laura
authors.initials: L
authors.lastname: Casaretti
authors.forename: Giuseppe Luca
authors.initials: GL
authors.lastname: Della Ratta
authors.forename: Susanna
authors.initials: S
authors.lastname: Mosca
authors.forename: Pasquale Perrone
authors.initials: PP
authors.lastname: Filardi
mesh_terms: D003331:Coronary Vessels; D003924:Diabetes Mellitus, Type 2 / Q000503:physiopathology*; D004730:Endothelium, Vascular / Q000503:physiopathology*; D005260:Female; D006801:Humans; D008297:Male; D008365:Manometry; D008875:Middle Aged