title: Singles engage the RNA interference pathway.
abstract: Single-stranded RNAs interact with components of the RNA interference pathway to reduce the expression of target mRNAs. Now, Lima et al. and Yu et al. show that, with extensive chemical modifications, small single-stranded RNAs can robustly induce gene silencing with efficacy similar to their double-stranded counterparts.
authors.forename: Beverly L
authors.initials: BL
authors.lastname: Davidson
authors.forename: Alex Mas
authors.initials: AM
authors.lastname: Monteys