title: [The function of lymphangiogenesis and the expression of Cathepsin D in laryngeal carcinoma metabasis].
abstract: OBJECTIVE
  To study the function of lymphangiogenesis and the expression of Cathepsin D (Cath-D) in laryngeal carcinoma metabasis and clinical pathology character.
  
  
  METHODS
  The expression of Cath-D were detected in 76 laryngeal carcinoma with immunohistochemistry (SP method). Podoplanin was used as the marker of lympgatic vessel endotheliocytes to label lympgatic vessel in 76 laryngeal carcinoma,lymphatic microvessel density were measured,and the paraneoplastic tissues was used as control group.
  
  
  RESULTS
  The positive rate of Cath-D in paraneoplastic tissue, laryngeal carcinoma and in pathology classification, in clinical stage, in cervicale lymphonode metastasis negative and positive group were significantly different. However, there had no difference between the positive rate of Cath-D in the age specific and clinical classification. c) The lymphatic microvessel density in paraneoplastic tissue, laryngeal carcinoma and clinical stage, in glottic carcinoma and supraglottic carcinoma, in cervical lymphonode metastasis negative and positive group were significantly different; but there had no difference in age-specific and pathology classification.
  
  
  CONCLUSIONS
  (1) The high expression of lymphatic microvessel density and the increasing expression of Cath-D could promote cervical lymphonode metastasis in aryngeal carcinoma. (2) There had a correlation between the high expression of lymphangiogenesis and Cath-D in laryngeal carcinoma, and had cooperation in aryngeal carcinoma lymphonode metastasis.
authors.affiliation: Department of Otolaryngology, the Second Affiliated Hospital of Bengbu Medical College, Bengbu, 233040, China.
authors.forename: Benlu
authors.initials: B
authors.lastname: Sun
authors.forename: Xiaodong
authors.initials: X
authors.lastname: Zhan
authors.forename: Chengyi
authors.initials: C
authors.lastname: Jiang
mesh_terms: D014408:Biomarkers, Tumor / Q000378:metabolism; D002277:Carcinoma / Q000378:metabolism* / Q000473:pathology / Q000503:physiopathology*; D002402:Cathepsin D / Q000378:metabolism*; D005260:Female; D005931:Glottis; D006801:Humans; D007150:Immunohistochemistry; D007822:Laryngeal Neoplasms / Q000378:metabolism* / Q000473:pathology / Q000503:physiopathology*; D042583:Lymphangiogenesis / Q000502:physiology*; D008207:Lymphatic Metastasis; D042601:Lymphatic Vessels / Q000378:metabolism; D008297:Male; D008562:Membrane Glycoproteins / Q000378:metabolism; D000098853:Podoplanin
chemical_list: D014408:Biomarkers, Tumor; D002402:Cathepsin D; D008562:Membrane Glycoproteins; C117468:PDPN protein, human; D000098853:Podoplanin