title: Evaluation of the effects of resveratrol and bevacizumab on experimental corneal alkali burn.
abstract: OBJECTIVE
  To evaluate the effects of resveratrol and bevacizumab on experimental corneal neovascularization.
  
  
  METHODS
  A corneal alkali burn was performed in 62 eyes of 31 male white Vienna rabbits. Resveratrol (group 1), dimethyl sulfoxide (group 2), bevacizumab (group 3) and 0.9% NaCl (group 4) were administered to both eyes of the rabbits by subconjunctival injection for 7 days. Corneal photos were taken at 15 days after alkali injury. Inflammatory index scores and neovascularization areas were calculated.
  
  
  RESULTS
  In bevacizumab group both inflammatory index scores and the calculation of the corneal neovascularization area was significantly less than the groups.
  
  
  CONCLUSIONS
  The subconjunctival administration of bevacizumab inhibits corneal neovascularization effectively in the rabbit corneal alkali burn model. No effect of resveratrol to the corneal neovascularization on experimental model of the corneal alkali burn was seen at the doses of usage.
authors.affiliation: Inonu University School of Medicine, Department of Ophthalmology, Malatya, Turkey. odoganay@windowslive.com
authors.forename: Selim
authors.initials: S
authors.lastname: Doganay
authors.forename: Penpe Gul
authors.initials: PG
authors.lastname: Firat
authors.forename: Cem
authors.initials: C
authors.lastname: Cankaya
authors.forename: Hale
authors.initials: H
authors.lastname: Kirimlioglu
mesh_terms: D000468:Alkalies / Q000009:adverse effects; D020533:Angiogenesis Inhibitors / Q000494:pharmacology*; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology*; D061067:Antibodies, Monoclonal, Humanized / Q000494:pharmacology*; D000068258:Bevacizumab; D002057:Burns, Chemical / Q000188:drug therapy*; D016510:Corneal Neovascularization / Q000188:drug therapy* / Q000209:etiology; D004195:Disease Models, Animal; D005126:Eye Burns / Q000150:complications / Q000188:drug therapy*; D008297:Male; D011817:Rabbits; D000077185:Resveratrol; D013267:Stilbenes / Q000494:pharmacology*
chemical_list: D000468:Alkalies; D020533:Angiogenesis Inhibitors; D000894:Anti-Inflammatory Agents, Non-Steroidal; D061067:Antibodies, Monoclonal, Humanized; D013267:Stilbenes; D000068258:Bevacizumab; D000077185:Resveratrol