title: Simplified International Index of Erectile Function (IIEF-5) and coronary artery disease in hypertensive patients.
abstract: BACKGROUND
  Erectile Dysfunction (ED) is associated with increased risk of coronary artery disease (CAD).
  
  
  OBJECTIVE
  To evaluate the association between ED, determined by the Simplified International Index of Erectile Function (IIEF-5) and CAD.
  
  
  METHODS
  This was a cross-sectional cohort study that evaluated 263 hypertensive patients (55 [50-61] years). ED was assessed through the IIEF-5 and CAD by the history of previous myocardial revascularization and/or coronary angiography.
  
  
  RESULTS
  The IIEF-5 correlated with creatinine clearance [CrCl] (Rho = 0.23, p <0.001) and age (Rho = -0.22, p <0.001). Forty-two patients had CAD, and IIEF-5 was able to discriminate them (area under the ROC curve = 0.63, p = 0.006). Patients were divided into two groups: IIEF-5 < 20 (n = 140) and IIEF-5 > 20 (n = 123); those with lower IIEF-5 scores were older (57 [52-61] vs. 54 [45-60] years, p = 0.002), had higher prevalence of CAD (22% vs. 9%, p = 0.004), smoking (64% vs. 47%, p = 0.009) and use of calcium channel inhibitors (65% vs. 43.%, p = 0.001), as well as lower CrCl (67.3 [30.8 to 88.6] vs. 82.6 [65.9 - 98.2] ml/min, p <0.001). The IIEF-5 < 21 was associated with increased risk of CAD in the logistic regression, both univariate (RR = 2.89 [95%CI: 1.39 - 6.05]), and after adjusting for age, diabetes, CrCl, smoking, mean arterial pressure and use of antihypertensive drugs (RR = 2.59 [95% CI: 1.01 - 6.61]).
  
  
  CONCLUSIONS
  The IIEF-5 is associated with the diagnosis of CAD and its use can add information to cardiovascular risk staging in hypertensive patients.
authors.affiliation: Instituto Dante Pazzanese de Cardiologia, São Paulo, SP, Brasil. antonio.cordeiro@cardiol.br
authors.forename: Antonio Carlos
authors.initials: AC
authors.lastname: Cordeiro
authors.forename: Carolina Christianini
authors.initials: CC
authors.lastname: Mizzaci
authors.forename: Rafael Modesto
authors.initials: RM
authors.lastname: Fernandes
authors.forename: Afrânio Galdino
authors.initials: AG
authors.lastname: Araujo-Junior
authors.forename: Paulo Oliveira
authors.initials: PO
authors.lastname: Cardoso
authors.forename: Lucas Velloso
authors.initials: LV
authors.lastname: Dutra
authors.forename: Amanda Guerra Moraes Rego
authors.initials: AG
authors.lastname: Sousa
authors.forename: Celso
authors.initials: C
authors.lastname: Amodeo
mesh_terms: D001794:Blood Pressure / Q000502:physiology; D003324:Coronary Artery Disease / Q000097:blood / Q000175:diagnosis / Q000209:etiology* / Q000503:physiopathology; D004812:Epidemiologic Methods; D007172:Erectile Dysfunction / Q000097:blood / Q000150:complications* / Q000503:physiopathology; D006801:Humans; D006973:Hypertension / Q000097:blood* / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D012307:Risk Factors; D012720:Severity of Illness Index