title: [Arterial-ischaemic stroke in childhood].
abstract: The risk to have a stroke during childhood is at least as frequent as to suffer from a brain tumour. Unlike adults, in whom ischaemic strokes overweigh haemorrhagic strokes, ischaemic and haemorrhagic strokes are equally frequent in children, occurring with an incidence of 2 - 3/100'000 children/year. Even though the clinical presentation of arterial-ischaemic stroke in children (pedAIS) is similar to adults, time to diagnosis is longer. The delay to diagnosis is mainly explained by the low index of suspicion of both the general population and the medical personnel, a broad range of differential diagnoses, and the fact that diagnostic imaging in children often requires sedation, which is not always readily available. PedAIS is a multiple risk problem, usually occurring due to a combination of risk factors, such as infectious diseases, dehydration, trauma or an underlying condition such as congenital heart disease. Still little is known about the appropriate management of pedAIS. Supportive measures are considered to be the mainstay of therapy. The use of antithrombotic medication depends on pedAIS aetiology. In an ongoing multicenter trial, the safety and effectiveness of thrombolysis are currently being investigated. PedAIS carries an important mortality and morbidity, with neurological and neuropsychological deficits persisting in two thirds of the affected children.
authors.affiliation: Universitätsklinik für Kinderheilkunde, Inselspital, Bern. barbara.goeggel-simonetti@insel.ch
authors.forename: B
authors.initials: B
authors.lastname: Goeggel Simonetti
authors.forename: M
authors.initials: M
authors.lastname: Steinlin
authors.forename: M
authors.initials: M
authors.lastname: Arnold
authors.forename: U
authors.initials: U
authors.lastname: Fischer
mesh_terms: D002648:Child; D016292:Procedural Sedation; D003430:Cross-Sectional Studies; D057210:Delayed Diagnosis; D003937:Diagnosis, Differential; D003952:Diagnostic Imaging; D006801:Humans; D015994:Incidence; D009460:Neurologic Examination; D011379:Prognosis; D012307:Risk Factors; D020521:Stroke / Q000175:diagnosis / Q000453:epidemiology / Q000209:etiology* / Q000628:therapy