title: Ovarian metastases of colorectal and duodenal cancer in familial adenomatous polyposis.
abstract: Metastases to the ovary occur in 0.8-9.7 % of colorectal cancer (CRC) cases (Hanna and Cohen in Clin Colorectal Cancer 3(4):215-222, 2004). The need to combine surgical resection of the primary tumor and bilateral oophorectomy is a matter of debate (Erroi et al. in J Surg Oncol 96(2):113-117, 2007). In a consecutive multi-hospital cohort of 30 CRC metastases to the ovary we came across four female patients (13 %; 95 % CI 3.6-34.1) with familial adenomatous polyposis (FAP). This number is high since the estimated incidence of FAP CRC is far below 1 % of all CRC and the expected incidence of FAP CRC that metastasized to the ovaries would thus be almost zero. In a second screen in nationwide databases we found that ovarian metastases occurred in at least 15 % of female FAP CRC cases. We provide now first evidence that especially in female FAP CRC patients bilateral oophorectomy during surgery should be discussed.
authors.affiliation: Department of Pathology, Leiden University Medical Center, Leiden, The Netherlands. a.s.l.p.crobach@lumc.nl
authors.forename: Stijn
authors.initials: S
authors.lastname: Crobach
authors.forename: Tom
authors.initials: T
authors.lastname: van Wezel
authors.forename: Hans F
authors.initials: HF
authors.lastname: Vasen
authors.forename: Hans
authors.initials: H
authors.lastname: Morreau
mesh_terms: D011125:Adenomatous Polyposis Coli / Q000150:complications* / Q000473:pathology / Q000601:surgery; D000328:Adult; D015331:Cohort Studies; D015179:Colorectal Neoplasms / Q000209:etiology* / Q000473:pathology / Q000601:surgery; D004379:Duodenal Neoplasms / Q000209:etiology* / Q000473:pathology / Q000601:surgery; D005260:Female; D006801:Humans; D008875:Middle Aged; D009367:Neoplasm Staging; D010051:Ovarian Neoplasms / Q000209:etiology* / Q000556:secondary / Q000601:surgery; D011379:Prognosis