title: Association between diastolic dysfunction by color tissue Doppler imaging and vascular calcification on plain radiographs in dialysis patients.
abstract: OBJECTIVE
  Diastolic dysfunction is frequently associated with left ventricular hypertrophy, which is indicative of future cardiovascular events. Vascular calcification (VC) is known to be associated with coronary artery disease in dialysis patients. The present study was to determine the interrelationship between LV diastolic dysfunction by tissue Doppler imaging and VC on plain radiographs in dialysis patients.
  
  
  METHODS
  Fifty-six dialysis patients were recruited and VC scores were evaluated by plain radiographic film. The ratio of early diastolic transmitral inflow velocity (E) to early diastolic mitral annular velocity (E') was measured by tissue Doppler imaging. We defined diastolic dysfunction as an E/E' ratio >15 on tissue Doppler imaging.
  
  
  RESULTS
  Patients with diastolic dysfunction showed a higher percentage of coronary artery disease history, abdominal aortic calcification (AAC) scores ≥5, high LV mass index, and high left atrium volume compared to patients without diastolic dysfunction. The E/E' ratio was significantly higher in patients with significant VC, VC scores of the pelvis and hands ≥3, and AAC scores ≥5 on plain radiographs. AAC scores ≥5 were considered an independent predictor of diastolic dysfunction.
  
  
  CONCLUSIONS
  VC on plain radiographs is associated with the E/E' ratio and AAC scores ≥5 are important clues for LV diastolic dysfunction in dialysis patients.
authors.affiliation: Department of Internal Medicine, Dong-A University College of Medicine, Busan, Republic of Korea.
authors.forename: Won Suk
authors.initials: WS
authors.lastname: An
authors.forename: Su Mi
authors.initials: SM
authors.lastname: Lee
authors.forename: Tae Ho
authors.initials: TH
authors.lastname: Park
authors.forename: Seong Eun
authors.initials: SE
authors.lastname: Kim
authors.forename: Ki Hyun
authors.initials: KH
authors.lastname: Kim
authors.forename: Young Jin
authors.initials: YJ
authors.lastname: Park
authors.forename: Young Ki
authors.initials: YK
authors.lastname: Son
mesh_terms: D000328:Adult; D000368:Aged; D003430:Cross-Sectional Studies; D003971:Diastole / Q000502:physiology; D005260:Female; D006801:Humans; D017379:Hypertrophy, Left Ventricular / Q000000981:diagnostic imaging* / Q000453:epidemiology* / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D006435:Renal Dialysis / Q000009:adverse effects; D018615:Ultrasonography, Doppler, Color / Q000379:methods*; D061205:Vascular Calcification / Q000000981:diagnostic imaging* / Q000453:epidemiology* / Q000503:physiopathology