title: Could spindle cell lung carcinoma be considered and treated as sarcoma, according to its clinical course, morphology, immunophenotype and genetic finding?
abstract: The actual nature of spindle cell carcinoma has been debated extensively because of its rarity. It carries a poor prognosis, even when early-stage disease is diagnosed and resected. In view of the rarity and the significance of the histological diagnosis, we report a patient with rapidly progressing spindle cell lung carcinoma with soft tissue metastasis. Diagnosis was confirmed by immunohistochemistry finding. Analysis of the TP53 gene mutations by polymerase chain reaction and DNA sequencing revealed insertion of single thymine resulting in frameshift mutation in the exon 8. Prognosis of spindle cell lung carcinoma might be determined by the sarcoma component of the tumor and, based on that, we wonder if this type of lung carcinoma could be followed-up and treated by strategies for soft tissue sarcomas, because of its rapid, sarcomatous type of growth, beside the properly lung carcinoma oncological treatment.
authors.affiliation: Pulmonology Clinic, Clinical Centre of Serbia, Medical Faculty, University in Belgrade, Belgrade, Serbia. milicakontic@yahoo.com
authors.forename: Milica
authors.initials: M
authors.lastname: Kontic
authors.forename: Jelena
authors.initials: J
authors.lastname: Stojsic
authors.forename: Ruza
authors.initials: R
authors.lastname: Stevic
authors.forename: Vera
authors.initials: V
authors.lastname: Bunjevacki
authors.forename: Biljana
authors.initials: B
authors.lastname: Jekić
authors.forename: Valerija
authors.initials: V
authors.lastname: Dobricic
mesh_terms: D000328:Adult; D001483:Base Sequence; D002277:Carcinoma / Q000235:genetics / Q000276:immunology / Q000473:pathology / Q000628:therapy*; D005260:Female; D006801:Humans; D016130:Immunophenotyping; D008175:Lung Neoplasms / Q000235:genetics / Q000276:immunology / Q000473:pathology / Q000628:therapy*; D008969:Molecular Sequence Data; D009154:Mutation; D009364:Neoplasm Recurrence, Local; D011379:Prognosis; D012509:Sarcoma / Q000235:genetics / Q000276:immunology / Q000473:pathology / Q000628:therapy*; D014057:Tomography, X-Ray Computed; D016159:Tumor Suppressor Protein p53 / Q000235:genetics
chemical_list: C495901:TP53 protein, human; D016159:Tumor Suppressor Protein p53