title: Adiponectin through its biphasic serum level is a useful biomarker during transition from diastolic dysfunction to systolic dysfunction - an experimental study.
abstract: BACKGROUND
  Adiponectin is reported to relate with cardiovascular diseases, we sought to examine whether adiponectin is associated with disease progression of heart failure from hypertension in rats in comparison with other known biomarkers and echocardiographic parameters. Spontaneously hypertensive rats (SHR, n = 35), aged 1 month, were used and followed up to 18 months. High frequency echocardiography was performed both at baseline and every 3 months thereafter. Moreover, serum levels of N-terminal pro-natriuretic peptide (NT-proBNP) and interleukin-6 (IL-6) as well as serum level and tissue expression of adiponectin were determined at the same time as echocardiography.
  
  
  RESULTS
  The results clearly demonstrated time-dependent progression of hypertension and heart dysfunction as evidenced by gradually increased left ventricular mass index, NT-proBNP, IL-6 as well as gradually decreased cardiac function as assessed by echocardiography. Meanwhile, tissue and serum adiponectin decreased from 3 months and reached plateau until 12 months in parallel with decreasing of cardiac diastolic function. Thereafter, adiponectin levels increased prior to occurrence of systolic dysfunction. Adiponectin concentration is inversely related with NT-proBNP, IL-6 and E/E' (correlation coefficient (r) = -0.756 for NT-proBNP, p < 0.001, -0.635 for IL-6, p = 0.002, and -0.626 for E/E', p = 0.002, respectively) while positively correlated with E/A and E'/A' (r = 0.683 for E/A, p = 0.001, 0.671 for E'/A', p = 0.001, respectively). No difference for adiponectin distribution among visceral adipose tissues was found.
  
  
  CONCLUSIONS
  Adiponectin through its biphasic serum level is a useful biomarker during transition from diastolic dysfunction to systolic dysfunction.
authors.affiliation: Shanghai Institute of Cardiovascular Diseases, Department of Cardiology, Zhongshan Hospital, Fudan University, Shanghai, China.
authors.forename: Mingqiang
authors.initials: M
authors.lastname: Fu
authors.forename: Jingmin
authors.initials: J
authors.lastname: Zhou
authors.forename: Juying
authors.initials: J
authors.lastname: Qian
authors.forename: Xuejuan
authors.initials: X
authors.lastname: Jin
authors.forename: Hongmin
authors.initials: H
authors.lastname: Zhu
authors.forename: Chunlin
authors.initials: C
authors.lastname: Zhong
authors.forename: Michael
authors.initials: M
authors.lastname: Fu
authors.forename: Yunzeng
authors.initials: Y
authors.lastname: Zou
authors.forename: Junbo
authors.initials: J
authors.lastname: Ge
mesh_terms: D052242:Adiponectin / Q000097:blood* / Q000235:genetics; D000818:Animals; D001483:Base Sequence; D015415:Biomarkers / Q000097:blood; D003971:Diastole / Q000502:physiology; D018450:Disease Progression; D015870:Gene Expression; D006333:Heart Failure / Q000097:blood / Q000000981:diagnostic imaging / Q000235:genetics / Q000503:physiopathology; D006973:Hypertension / Q000097:blood* / Q000000981:diagnostic imaging / Q000235:genetics / Q000503:physiopathology*; D015850:Interleukin-6 / Q000097:blood / Q000235:genetics; D008297:Male; D020097:Natriuretic Peptide, Brain / Q000097:blood; D010446:Peptide Fragments / Q000097:blood; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D051381:Rats; D011918:Rats, Inbred SHR; D013599:Systole / Q000502:physiology; D014463:Ultrasonography
chemical_list: D052242:Adiponectin; C499920:Adipoq protein, rat; D015415:Biomarkers; D015850:Interleukin-6; D010446:Peptide Fragments; D012333:RNA, Messenger; C109794:pro-brain natriuretic peptide (1-76); D020097:Natriuretic Peptide, Brain