title: Two new metabolites from a soil fungus Curvularia affinis strain HS-FG-196.
abstract: Two new metabolites, pyrenocine J (1) and pyrenochaetic acid D (2), together with two known metabolites, pyrenocine A (3) and pyrenochaetic acid A (4), were isolated from a soil fungus, Curvularia affinis strain HS-FG-196. Their structures were established by extensive spectroscopic analysis. Compound 1 showed cytotoxic activity against the human hepatic cancer cell line HepG2 with an IC(50) value of 28.5 μg/ml.
authors.affiliation: College of Pharmaceutical Science, Zhejiang University of Technology, Hangzhou 310014, China.
authors.forename: Hui
authors.initials: H
authors.lastname: Zhang
authors.forename: Liang-Liang
authors.initials: LL
authors.lastname: Mao
authors.forename: Ping-Ting
authors.initials: PT
authors.lastname: Qian
authors.forename: Wei-Guang
authors.initials: WG
authors.lastname: Shan
authors.forename: Ji-Dong
authors.initials: JD
authors.lastname: Wang
authors.forename: Hua
authors.initials: H
authors.lastname: Bai
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D001203:Ascomycota / Q000737:chemistry*; D004354:Drug Screening Assays, Antitumor; D056945:Hep G2 Cells; D006801:Humans; D020128:Inhibitory Concentration 50; D015394:Molecular Structure; D011753:Pyrones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology
chemical_list: D000970:Antineoplastic Agents; D011753:Pyrones; C578806:pyrenochaetic acid D; C578805:pyrenocine J