title: Clinical and pathological examples of Alzheimer's disease, dementia with Lewy bodies, and frontotemporal dementia.
abstract: Dementia syndromes usually consist of distinct clinical and pathological phenotypes. A careful history is required to document the onset and progression of symptoms to generate the differential diagnosis. New biomarker tests can provide evidence to increase diagnostic certainty. Disease-specific interventions, based on advances in genetic and molecular biomarkers, are likely to have the greatest impact when given in preclinical and early symptomatic phases.
authors.affiliation: Warren Alpert Medical School of Brown University, USA. ssalloway@butler.org
authors.forename: Stephen
authors.initials: S
authors.lastname: Salloway
mesh_terms: D000368:Aged; D000544:Alzheimer Disease / Q000175:diagnosis* / Q000473:pathology; D002800:Cholinesterase Inhibitors / Q000494:pharmacology; D003937:Diagnosis, Differential; D005260:Female; D057180:Frontotemporal Dementia / Q000175:diagnosis* / Q000473:pathology; D006801:Humans; D020961:Lewy Body Disease / Q000175:diagnosis* / Q000473:pathology; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests; D010641:Phenotype; D049268:Positron-Emission Tomography
chemical_list: D002800:Cholinesterase Inhibitors