title: Enantioseparation of α-hydroxy acids by chiral ligand exchange CE with a dual central metal ion system.
abstract: Using two kinds of central metal ions in a background electrolyte, ligand exchange CE was investigated for the simultaneous enantioseparation of dl-malic, dl-tartaric, and dl-isocitric acids. Ligand exchange CE with 100 mM d-quinic acid as a chiral selector ligand and 10 mM Cu(II) ion as a central metal ion could enantioseparate dl-tartaric acid but not dl-malic acid or dl-isocitric acid. A dual central metal ion system containing 0.5 mM Al(III) ion in addition to 10 mM Cu(II) ion in the background electrolyte enabled the simultaneous enantioseparation of the three α-hydroxy acids. These results suggest that the use of a dual central metal ion system can be useful for enantioseparation by ligand exchange CE.
authors.affiliation: Toyama Institute of Health, Imizu, Toyama, Japan.
authors.forename: Shuji
authors.initials: S
authors.lastname: Kodama
authors.forename: Atsushi
authors.initials: A
authors.lastname: Yamamoto
authors.forename: Sen-Ichi
authors.initials: S
authors.lastname: Aizawa
authors.forename: Yoshitaka
authors.initials: Y
authors.lastname: Honda
authors.forename: Kentaro
authors.initials: K
authors.lastname: Suzuki
authors.forename: Tomoko
authors.initials: T
authors.lastname: Kemmei
authors.forename: Atsushi
authors.initials: A
authors.lastname: Taga
mesh_terms: D000144:Acids, Acyclic / Q000737:chemistry / Q000302:isolation & purification; D019075:Electrophoresis, Capillary / Q000295:instrumentation / Q000379:methods*; D006880:Hydroxy Acids / Q000737:chemistry / Q000302:isolation & purification*; D008024:Ligands; D019216:Metals, Heavy / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D000144:Acids, Acyclic; D006880:Hydroxy Acids; D008024:Ligands; D019216:Metals, Heavy