title: Tabebuialdehydes A-C, cyclopentene dialdehyde derivatives from the roots of Tabebuia rosea.
abstract: Two new cyclopentene dialdehydes, tabebuialdehydes A and B (1 and 2) and a new dihydrocyclopenta[c]furan monoaldehyde, tabebuialdehyde C (3), along with ten known compounds were isolated from the roots of Tabebuia rosea. The structures of all isolated compounds were elucidated through their physical properties and by the use of spectroscopic methods, as well as comparisons with previous literature data. Moreover, all isolated compounds were evaluated for their cytotoxicity (KB and HeLa cell lines). Compounds 6, 7 and 9 showed significant cytotoxicity against both KB and HeLa cells with IC(50) values of 1.35 and 1.15, 0.53 and 0.77, 1.79 and 0.73μg/mL, respectively.
authors.affiliation: Natural Products Research Unit, Department of Chemistry, Faculty of Science, Chulalongkorn University, Bangkok 10330, Thailand.
authors.forename: Jirapast
authors.initials: J
authors.lastname: Sichaem
authors.forename: Sutin
authors.initials: S
authors.lastname: Kaennakam
authors.forename: Pongpun
authors.initials: P
authors.lastname: Siripong
authors.forename: Santi
authors.initials: S
authors.lastname: Tip-pyang
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000494:pharmacology*; D003517:Cyclopentanes / Q000737:chemistry / Q000494:pharmacology*; D006801:Humans; D015394:Molecular Structure; D018517:Plant Roots / Q000737:chemistry*; D029663:Tabebuia / Q000737:chemistry*
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D003517:Cyclopentanes