title: Direct arylation/alkylation/magnesiation of benzyl alcohols in the presence of Grignard reagents via Ni-, Fe-, or Co-catalyzed sp3 C-O bond activation.
abstract: Direct application of benzyl alcohols (or their magnesium salts) as electrophiles in various reactions with Grignard reagents has been developed via transition metal-catalyzed sp(3) C-O bond activation. Ni complex was found to be an efficient catalyst for the first direct cross coupling of benzyl alcohols with aryl/alkyl Grignard reagents, while Fe, Co, or Ni catalysts could promote the unprecedented conversion of benzyl alcohols to benzyl Grignard reagents in the presence of (n)hexylMgCl. These methods offer straightforward pathways to transform benzyl alcohols into a variety of functionalities.
authors.affiliation: Beijing National Laboratory of Molecular Sciences, College of Chemistry, Peking University, Beijing 10087, China.
authors.forename: Da-Gang
authors.initials: DG
authors.lastname: Yu
authors.forename: Xin
authors.initials: X
authors.lastname: Wang
authors.forename: Ru-Yi
authors.initials: RY
authors.lastname: Zhu
authors.forename: Shuang
authors.initials: S
authors.lastname: Luo
authors.forename: Xiao-Bo
authors.initials: XB
authors.lastname: Zhang
authors.forename: Bi-Qin
authors.initials: BQ
authors.lastname: Wang
authors.forename: Lei
authors.initials: L
authors.lastname: Wang
authors.forename: Zhang-Jie
authors.initials: ZJ
authors.lastname: Shi
mesh_terms: D000478:Alkylation; D001592:Benzyl Alcohols / Q000737:chemistry*; D001593:Benzyl Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D002384:Catalysis; D003035:Cobalt / Q000737:chemistry; D007202:Indicators and Reagents; D007501:Iron / Q000737:chemistry; D008274:Magnesium / Q000737:chemistry*; D015394:Molecular Structure; D009532:Nickel / Q000737:chemistry; D009942:Organometallic Compounds / Q000138:chemical synthesis* / Q000737:chemistry*
chemical_list: D001592:Benzyl Alcohols; D001593:Benzyl Compounds; D007202:Indicators and Reagents; D009942:Organometallic Compounds; D003035:Cobalt; D009532:Nickel; D007501:Iron; D008274:Magnesium