title: Oral alitretinoin: a review of the clinical pharmacokinetics and pharmacodynamics.
abstract: Alitretinoin is an endogenous retinoid related to vitamin A. Studies have shown that oral alitretinoin is effective and well tolerated in the treatment of severe chronic hand eczema. This review summarizes the clinical pharmacokinetic and pharmacodynamic data from a number of studies involving alitretinoin. These include the effect of food on the pharmacokinetics of alitretinoin, interactions between alitretinoin and ketoconazole, simvastatin or cyclosporin A, the effect of alitretinoin on the pharmacokinetics of a combined oral contraceptive, alitretinoin in seminal fluid after repeated dosing, and the pharmacokinetics of alitretinoin and its metabolites in a clinical setting.
authors.affiliation: Basilea Pharmaceutica International Ltd, Basel, Switzerland. anne.schmitt-hoffmann@basilea.com
authors.forename: A H
authors.initials: AH
authors.lastname: Schmitt-Hoffmann
authors.forename: B
authors.initials: B
authors.lastname: Roos
authors.forename: A
authors.initials: A
authors.lastname: Schoetzau
authors.forename: P T
authors.initials: PT
authors.lastname: Leese
authors.forename: I
authors.initials: I
authors.lastname: Meyer
authors.forename: J
authors.initials: J
authors.lastname: van de Wetering
authors.forename: P
authors.initials: P
authors.lastname: Kovacs
mesh_terms: D000284:Administration, Oral; D000077556:Alitretinoin; D000818:Animals; D002908:Chronic Disease; D003879:Dermatologic Agents / Q000008:administration & dosage* / Q000493:pharmacokinetics / Q000494:pharmacology; D004347:Drug Interactions; D004485:Eczema / Q000188:drug therapy* / Q000473:pathology; D018565:Food-Drug Interactions; D006229:Hand Dermatoses / Q000188:drug therapy / Q000473:pathology; D006801:Humans; D014212:Tretinoin / Q000008:administration & dosage* / Q000493:pharmacokinetics / Q000494:pharmacology
chemical_list: D003879:Dermatologic Agents; D000077556:Alitretinoin; D014212:Tretinoin