title: Gastroesophageal reflux disease in lung transplant patients with cystic fibrosis.
abstract: BACKGROUND
  Gastroesophageal reflux disease (GERD) in lung transplant patients is being increasingly investigated because of its reported association with chronic rejection. However, information concerning the characteristics of GERD in cystic fibrosis (CF) patients is scarce.
  
  
  METHODS
  We compared esophageal pH monitoring, manometry, gastric emptying studies, and barium swallow of 10 lung transplant patients with CF with those of 78 lung transplant patients with other end-stage pulmonary diseases.
  
  
  RESULTS
  In lung transplant patients with CF, the prevalence of GERD was 90% (vs 54% controls, P = .04), of whom 70% had proximal reflux (vs 29% controls, P = .02).
  
  
  CONCLUSIONS
  Lung transplant patients with CF have a significantly higher prevalence and proximal extent of GERD than do other lung transplant recipients. These data suggest that CF patients in particular should be routinely screened for GERD after transplantation to identify those who may benefit from antireflux surgery, especially given the risks of GERD-related aspiration and chronic allograft injury.
authors.affiliation: Department of Surgery, Loyola University Chicago, Stritch School of Medicine, Maywood, IL 60153, USA.
authors.forename: Bernardino M
authors.initials: BM
authors.lastname: Mendez
authors.forename: Christopher S
authors.initials: CS
authors.lastname: Davis
authors.forename: Cynthia
authors.initials: C
authors.lastname: Weber
authors.forename: Raymond J
authors.initials: RJ
authors.lastname: Joehl
authors.forename: P Marco
authors.initials: PM
authors.lastname: Fisichella
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001466:Barium Sulfate; D016022:Case-Control Studies; D003287:Contrast Media; D003550:Cystic Fibrosis / Q000150:complications / Q000601:surgery*; D050782:Esophageal pH Monitoring; D005260:Female; D005746:Gastric Emptying; D005764:Gastroesophageal Reflux / Q000175:diagnosis / Q000453:epidemiology / Q000209:etiology*; D006801:Humans; D016040:Lung Transplantation; D008297:Male; D008365:Manometry; D008875:Middle Aged; D011183:Postoperative Complications / Q000175:diagnosis / Q000453:epidemiology; D015995:Prevalence; D012189:Retrospective Studies; D055815:Young Adult
chemical_list: D003287:Contrast Media; D001466:Barium Sulfate