title: Oxytocin and catechol-O-methyltransferase receptor genotype predict the length of the first stage of labor.
abstract: OBJECTIVE
  We aimed to identify genetic factors that influence the rate of the first stage of labor.
  
  
  METHODS
  We prospectively enrolled 233 laboring nulliparous parturients. Demographic, clinical, and genetic data were collected. We evaluated the influence of population and individual variability using a nonlinear mixed effects model.
  
  
  RESULTS
  Parturients who were homozygous for "G" at oxytocin receptor gene rs53576 transitioned to active labor later and thus had slower labor. Catechol-O-methyltransferase rs4633 genotype TT was associated with slower latent phase labor. Labor induction with prostaglandin was associated with faster labor, and request for meperidine was associated with slower labor. Birthweight was related inversely to the rate of the active phase.
  
  
  CONCLUSIONS
  There are demographic, clinical, and genetic factors that influence an individual's rate of labor progress. This information could be used in automated form to improve the prediction of the length of the first stage of labor.
authors.affiliation: Department of Anesthesiology, King Farad Medical City, Riyadh, Saudi Arabia.
authors.forename: Abdullah S
authors.initials: AS
authors.lastname: Terkawi
authors.forename: William M
authors.initials: WM
authors.lastname: Jackson
authors.forename: Mari-Paule
authors.initials: MP
authors.lastname: Thiet
authors.forename: Shehnaz
authors.initials: S
authors.lastname: Hansoti
authors.forename: Rabeena
authors.initials: R
authors.lastname: Tabassum
authors.forename: Pamela
authors.initials: P
authors.lastname: Flood
mesh_terms: D000293:Adolescent; D000328:Adult; D002394:Catechol O-Methyltransferase / Q000235:genetics*; D005260:Female; D005838:Genotype; D006801:Humans; D007747:Labor Stage, First / Q000235:genetics* / Q000502:physiology*; D010121:Oxytocin; D011247:Pregnancy; D011446:Prospective Studies; D018045:Receptors, Oxytocin / Q000235:genetics*; D013997:Time Factors; D055815:Young Adult
chemical_list: C569600:OXTR protein, human; D018045:Receptors, Oxytocin; D010121:Oxytocin; D002394:Catechol O-Methyltransferase