title: A cytotoxic cardenolide and a saponin from the rhizomes of Tupistra chinensis.
abstract: A new cardenolide tupichinolide (1) and a new steroidal saponin tupichinin A (2), together with seven known compounds, were isolated from the rhizomes of Tupistra chinensis. Their structures were established using spectroscopic analysis and chemical methods. Compound 1 was the first cardenolide isolated from Tupistra chinensis and exhibited potent cytotoxicity against five human cancer cell lines: HL-60, SMMC-7721, A-549, MCF-7 and SW480.
authors.affiliation: Guangxi Key Laboratory of Functional Phytochemicals Research and Utilization, Guangxi Institute of Botany, Chinese Academy of Sciences, Guilin 541006, China. pan9418@yahoo.com.cn
authors.forename: Zheng-Hong
authors.initials: ZH
authors.lastname: Pan
authors.forename: Yan
authors.initials: Y
authors.lastname: Li
authors.forename: Jin-Lei
authors.initials: JL
authors.lastname: Liu
authors.forename: De-Sheng
authors.initials: DS
authors.lastname: Ning
authors.forename: Dian-Peng
authors.initials: DP
authors.lastname: Li
authors.forename: Xing-De
authors.initials: XD
authors.lastname: Wu
authors.forename: Yong-Xin
authors.initials: YX
authors.lastname: Wen
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000494:pharmacology*; D002298:Cardenolides / Q000737:chemistry*; D045744:Cell Line, Tumor; D006801:Humans; D019668:Liliaceae / Q000737:chemistry*; D015394:Molecular Structure; D027343:Rhizome / Q000737:chemistry*; D012503:Saponins / Q000737:chemistry*
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D002298:Cardenolides; D012503:Saponins; C581114:tupichinolide