title: Trisomy 19 and t(9;22) in a patient with acute basophilic leukemia.
abstract: We report a case of acute basophilic leukemia with two coexisting clonal abnormalities, t(9;22) and trisomy 19. The blast showed positive reaction with myeloperoxidase but negative reaction with chloroacetate esterase and acid phosphatase. Metachromatic features of the blast were observed with toluidine blue stain. Ultrastructure study showed the presence of azurophilic granules in basophils and blast mast cells. Conventional and molecular cytogenetic studies revealed, t(9;22) with BCR/ABL positive and trisomy 19 in all metaphase cells. To our knowledge, this paper here is the first to present acute basophilic leukemia with trisomy 19 and t(9;22).
authors.affiliation: Genetic Medical Unity, Faculty of Medicine, University of Zulia, Maracaibo, Venezuela.
authors.forename: Alicia
authors.initials: A
authors.lastname: Rojas-Atencio
authors.forename: Karelis
authors.initials: K
authors.lastname: Urdaneta
authors.forename: Marisol
authors.initials: M
authors.lastname: Soto-Quintana
authors.forename: Francisco
authors.initials: F
authors.lastname: Alvarez Nava
authors.forename: Jenny
authors.initials: J
authors.lastname: Cañizales
authors.forename: Ernesto
authors.initials: E
authors.lastname: Solis