title: The incidence of type 1 diabetes in Republic of Srpska (Bosnia and Herzegovina) and Slovenia in the period 1998-2010.
abstract: OBJECTIVE
  To establish and compare the incidence and trends of type 1 diabetes mellitus (T1DM) in Republic of Srpska and Slovenia in age group 0-18 yr from 1998 to 2010.
  
  
  METHODS
  The subjects (413 newly diagnosed T1DM patients in the Republic of Srpska and 664 in Slovenia) were grouped into the age groups: 0-4, 5-9, 10-14, and 15-18 yr. Confidence intervals (CI) for crude incidence rates were estimated assuming numbers of cases were counts from the Poisson distribution. Gender and age-specific standardization was done according to the EURODIAB criteria. Statistical analysis used Poisson-regression models to analyze difference rate between countries and to investigate the incidence trend.
  
  
  RESULTS
  Case ascertainment was estimated to be 99.95% for the Republic of Srpska and 100% for Slovenia by using the capture-recapture method. The standardized incidence of T1DM for age group 0-18 yr in the Republic of Srpska was 7.5/100 000/yr (95% CI: 6.8-8.3). For the same period and the same age group incidence in Slovenia was 12.5/100 000/yr (95% CI: 11.5-13.5). Annual increase in the incidence in the Republic of Srpska was 2.3% (95% CI: -0.3 to 5.0%), whereas in Slovenia 4.3% (95% CI: 2.2-6.5%).
  
  
  CONCLUSIONS
  The incidence for age group 0-18 yr standardized to the world population is remarkably higher in Slovenia than in the Republic of Srpska. Further follow-up and investigations are needed to explain the high difference in incidence of T1DM between the two geographically related countries.
authors.affiliation: Clinic for Endocrinology, Diabetes and Metabolic diseases, Clinical Centre Banja Luka, and School of Medicine, University of Banja Luka, 78000, Banja Luka, Republic of Srpska, Bosnia and Herzegovina. bojana.radosevic@kc-bl.com
authors.forename: Bojana
authors.initials: B
authors.lastname: Radosevic
authors.forename: Gordana
authors.initials: G
authors.lastname: Bukara-Radujkovic
authors.forename: Vesna
authors.initials: V
authors.lastname: Miljkovic
authors.forename: Snjezana
authors.initials: S
authors.lastname: Pejicic
authors.forename: Natasa
authors.initials: N
authors.lastname: Bratina
authors.forename: Tadej
authors.initials: T
authors.lastname: Battelino
mesh_terms: D000293:Adolescent; D017522:Bosnia and Herzegovina; D002648:Child; D002675:Child, Preschool; D003922:Diabetes Mellitus, Type 1 / Q000453:epidemiology*; D005260:Female; D006801:Humans; D015994:Incidence; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D017524:Slovenia