title: Serum cardiac troponin I concentrations in horses with cardiac disease.
abstract: OBJECTIVE
  To measure the cardiac troponin I (cTnI) concentration in horses and determine whether it could be used in the diagnosis of myocardial disease, as well as determining the association between cTnI and survival.
  
  
  METHODS
  Prospective, observational study.
  
  
  METHODS
  Physical examination, echocardiography, telemetric electrocardiography and postmortem were used to diagnose cardiac disease. Diagnoses were grouped as myocardial disease, structural heart disease or lone arrhythmia. Blood samples were collected at admission for cTnI analysis and the results were compared with those for 18 healthy horses.
  
  
  RESULTS
  In total, 49 horses were admitted with cardiac disease. Elevated cTnI concentration (>0.03 ng/mL) was observed in a greater proportion of horses with myocardial disease (7/7), compared with healthy horses (0/18; P < 0.0001), horses with structural heart disease (7/25; P = 0.001), and horses with a lone arrhythmia (2/17; P = 0.0001). The median cTnI concentration for horses with myocardial disease was 17.5 ng/mL (range 0.78-49.87 ng/mL), which was higher than in the healthy horses (0.01 ng/mL, range 0.01-0.03 ng/mL; P < 0.0001). Of the 49 horses with cardiac disease, the median cTnI concentration for non-survivors (0.28 ng/mL, range 0.01-49.87 ng/mL) was higher than for survivors (0.01 ng/mL, range 0.01-30.31 ng/mL; P = 0.0035). However, the proportion of surviving horses with an elevated cTnI (10/39, 26%) was not significantly different from the proportion of non-surviving horses with an elevated cTnI (6/10, 60%; P = 0.060).
  
  
  CONCLUSIONS
  cTnI is elevated in horses with myocardial disease and elevated to a lesser degree in some horses with structural heart disease or lone arrhythmias. The association between cTnI concentration and survival was not clear.
authors.affiliation: University of Melbourne, Werribee, Victoria, Australia. lc_fennell@yahoo.com.au
authors.forename: L C
authors.initials: LC
authors.lastname: Nath
authors.forename: G A
authors.initials: GA
authors.lastname: Anderson
authors.forename: K W
authors.initials: KW
authors.lastname: Hinchcliff
authors.forename: C J
authors.initials: CJ
authors.lastname: Savage
mesh_terms: D000818:Animals; D015415:Biomarkers / Q000097:blood; D009202:Cardiomyopathies / Q000097:blood / Q000175:diagnosis / Q000662:veterinary*; D016022:Case-Control Studies; D004562:Electrocardiography / Q000662:veterinary; D005260:Female; D006331:Heart Diseases / Q000097:blood / Q000175:diagnosis / Q000662:veterinary*; D006734:Horse Diseases / Q000097:blood / Q000175:diagnosis*; D006736:Horses; D008297:Male; D011446:Prospective Studies; D012680:Sensitivity and Specificity; D019210:Troponin I / Q000097:blood*
chemical_list: D015415:Biomarkers; D019210:Troponin I