title: Methylprednisolone use is associated with endothelial cell activation following cardiac surgery.
abstract: BACKGROUND
  The objective of this study was to investigate the effect of the perioperative use of methylprednisolone in medium doses on markers of endothelial cell activation in patients with coronary artery disease undergoing cardiopulmonary bypass.
  
  
  METHODS
  In this prospective, double-blinded, placebo-controlled, randomised study, 44 patients, undergoing a coronary artery bypass graft surgery received either methylprednisolone 20 mg/kg or a placebo intraoperatively after anaesthesia induction. The primary endpoint was endothelin-1, and secondary endpoints were E-selectin, interleukin (IL)-6 and IL-10, PaO(2)/FiO(2) coefficient, and microalbuminuria.
  
  
  RESULTS
  Endothelin-1 was higher in the study group postoperatively at 10 min (p=0.0008), 2 h (p=0.02), 4 h (p=0.005), and 24 h (p=0.004). IL-6 was lower in the study group postoperatively at 2 h (p=0.03), 4 h (p=0.04), and 24 h (p<0.0001). IL-10 was higher in the study group postoperatively at 10 min (p<0.0001), 2 h (p=0.009), and 4 h (p=0.001). PaO(2)/FiO(2) was lower in the study group at 24 h after surgery (p=0.03). Microalbuminuria was similar in both groups.
  
  
  CONCLUSIONS
  Despite an obvious anti-inflammatory effect, methylprednisolone causes endothelial cell activation in patients undergoing cardiopulmonary bypass.
authors.affiliation: Research Institute of Circulation Pathology, Rechkunovskaya Street 15, Novosibirsk 630055, Russia.
authors.forename: Vladimir V
authors.initials: VV
authors.lastname: Lomivorotov
authors.forename: Sergey M
authors.initials: SM
authors.lastname: Efremov
authors.forename: Andrey P
authors.initials: AP
authors.lastname: Kalinichenko
authors.forename: Igor A
authors.initials: IA
authors.lastname: Kornilov
authors.forename: Lubov G
authors.initials: LG
authors.lastname: Knazkova
authors.forename: Alexandr M
authors.initials: AM
authors.lastname: Chernyavskiy
authors.forename: Vladimir N
authors.initials: VN
authors.lastname: Lomivorotov
authors.forename: Alexander M
authors.initials: AM
authors.lastname: Karaskov
mesh_terms: D000368:Aged; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage*; D001026:Coronary Artery Bypass; D004311:Double-Blind Method; D019040:E-Selectin / Q000097:blood; D019332:Endothelin-1 / Q000097:blood; D004730:Endothelium, Vascular / Q000378:metabolism* / Q000473:pathology / Q000503:physiopathology; D005260:Female; D006801:Humans; D016753:Interleukin-10 / Q000097:blood; D015850:Interleukin-6 / Q000097:blood; D008297:Male; D008775:Methylprednisolone / Q000008:administration & dosage*; D008875:Middle Aged; D011184:Postoperative Period; D011446:Prospective Studies; D013997:Time Factors
chemical_list: D000893:Anti-Inflammatory Agents; D019040:E-Selectin; D019332:Endothelin-1; C508609:IL10 protein, human; C508600:IL6 protein, human; D015850:Interleukin-6; D016753:Interleukin-10; D008775:Methylprednisolone