title: Preparation and evaluation of single and co-engineered combination inhalation carrier formulations for the treatment of asthma.
abstract: Two combination dry powder inhalation formulations were engineered via spray drying and co-spray drying salbutamol base (SB) and beclomethasone dipropionate (BDP). The aerosol performances of the individual drugs, a physical mix and the co-spray-dried particle systems were investigated after blending with conventional lactose carrier, under realistic dose regimes. Furthermore, each system was evaluated in terms of the physicochemical properties and via high-throughput Raman microscopy (to study co-association and deposition patterns after in vitro aerosolisation studies). In general, analysis of the aerosol performance (measured using a next-generation impactor) of the single drug and physical mix formulations suggested that SB and BDP have significantly different stage-deposition profiles. Such observations were further substantiated by scanning electron microscopy, where SB-BDP agglomeration could be observed in the physical mix. Stage deposition from the SB-BDP co-spray-dried powders were different than that for the physical mix, wherein the amount of SB and BDP on each stage was equivalent; suggesting that the two drugs could be targeted and deposited at the same location on the lung epithelia. Raman microscopy of the physical mix and co-spray-dried formulations also confirmed the differences in stage deposition between formulations and co-localised deposition for the co-spray-dried formulation.
authors.affiliation: Woolcock Institute of Medical Research, New South Wales 2037, Australia.
authors.forename: Daniela
authors.initials: D
authors.lastname: Traini
authors.forename: Handoko
authors.initials: H
authors.lastname: Adi
authors.forename: Oliver K
authors.initials: OK
authors.lastname: Valet
authors.forename: Paul M
authors.initials: PM
authors.lastname: Young
mesh_terms: D000280:Administration, Inhalation; D000336:Aerosols; D018927:Anti-Asthmatic Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D001249:Asthma / Q000188:drug therapy*; D002152:Calorimetry, Differential Scanning; D004337:Drug Carriers; D006801:Humans; D008855:Microscopy, Electron, Scanning; D010316:Particle Size; D033362:Powder Diffraction; D013059:Spectrum Analysis, Raman
chemical_list: D000336:Aerosols; D018927:Anti-Asthmatic Agents; D004337:Drug Carriers