title: Historical control data on prenatal developmental toxicity studies in rabbits.
abstract: Historical control data on rabbit prenatal developmental toxicity studies, performed between 1994-2010, were obtained from 20 laboratories, including 11 pharmaceutical and chemical companies and nine contract laboratories, in Japan. In this paper, data were incorporated from a laboratory if the information was based on 10 studies or more. Japanese White rabbits and New Zealand White rabbits were used for prenatal developmental toxicity studies. The data included maternal reproductive findings at terminal cesarean sections and fetal findings including spontaneous incidences of morphological alterations. No noticeable differences between strains or laboratories were observed in the maternal reproductive and fetal developmental data. The inter-laboratory variations in the incidences of fetal external, visceral, and skeletal alterations seem to be due to differences in the selection of observation parameters, observation criteria, and classification of the findings, and terminology of fetal alterations.
authors.affiliation: Study Group for Historical Control Data on Prenatal Developmental Toxicity Studies in Rabbits, Research Institute of Sciencefor Safety and Sustainability, National Institute of Advanced IndustrialScience and Technology (AIST), 16-1 Onogawa, Tsukuba, Ibaraki, Japan. ema-makoto@aist.go.jp
authors.forename: Makoto
authors.initials: M
authors.lastname: Ema
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Aoyama
authors.forename: Akihiro
authors.initials: A
authors.lastname: Arima
authors.forename: Yuzo
authors.initials: Y
authors.lastname: Asano
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Chihara
authors.forename: Katsumi
authors.initials: K
authors.lastname: Endoh
authors.forename: Sakiko
authors.initials: S
authors.lastname: Fujii
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Hara
authors.forename: Hashihiro
authors.initials: H
authors.lastname: Higuchi
authors.forename: Atsuko
authors.initials: A
authors.lastname: Hishikawa
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Hojo
authors.forename: Masao
authors.initials: M
authors.lastname: Horimoto
authors.forename: Nobuhito
authors.initials: N
authors.lastname: Hoshino
authors.forename: Yoshinori
authors.initials: Y
authors.lastname: Hosokawa
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Inada
authors.forename: Ayumi
authors.initials: A
authors.lastname: Inoue
authors.forename: Keiichi
authors.initials: K
authors.lastname: Itoh
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Izumi
authors.forename: Maki
authors.initials: M
authors.lastname: Maeda
authors.forename: Kiyoshi
authors.initials: K
authors.lastname: Matsumoto
authors.forename: Seiki
authors.initials: S
authors.lastname: Matsuo
authors.forename: Ikuo
authors.initials: I
authors.lastname: Matsuura
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Mineshima
authors.forename: Yoji
authors.initials: Y
authors.lastname: Miwa
authors.forename: Hidenori
authors.initials: H
authors.lastname: Miyata
authors.forename: Yasumoto
authors.initials: Y
authors.lastname: Mizoguchi
authors.forename: Nao
authors.initials: N
authors.lastname: Nakano
authors.forename: Masato
authors.initials: M
authors.lastname: Naya
authors.forename: Hanako
authors.initials: H
authors.lastname: Nishizawa
authors.forename: Ken-Ichi
authors.initials: K
authors.lastname: Noritake
authors.forename: Hiroko
authors.initials: H
authors.lastname: Noyori
authors.forename: Takafumi
authors.initials: T
authors.lastname: Ohta
authors.forename: Harutaka
authors.initials: H
authors.lastname: Oku
authors.forename: Tatsuya
authors.initials: T
authors.lastname: Shimizu
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Shimomura
authors.forename: Kei
authors.initials: K
authors.lastname: Shiozawa
authors.forename: Ikuro
authors.initials: I
authors.lastname: Takakura
authors.forename: Ryota
authors.initials: R
authors.lastname: Tanaka
authors.forename: Tohru
authors.initials: T
authors.lastname: Uesugi
authors.forename: Kaoru
authors.initials: K
authors.lastname: Yabe
authors.forename: Toshiaki
authors.initials: T
authors.lastname: Yamauchi
authors.forename: Ryohei
authors.initials: R
authors.lastname: Yokoi
mesh_terms: D000014:Abnormalities, Drug-Induced / Q000209:etiology*; D000818:Animals; D004195:Disease Models, Animal; D005260:Female; D005333:Fetus / Q000002:abnormalities / Q000187:drug effects; D011247:Pregnancy; D011817:Rabbits; D013723:Teratogens / Q000633:toxicity*
chemical_list: D013723:Teratogens