title: [Type I interferon and bacterial infection].
abstract: Interferons (IFNs) are cytokines playing an important role in immune responses. Interferons are classified into two distinct types according to specific interferon receptors(IFNR). Type I IFNs include IFN-α and IFN-β, whereas IFN-γ is type II IFN. It is well known that type I IFNs have important roles in the host defense against viruses through activation of interferon receptor A (IFNAR). However, many recent studies have also demonstrated that type I IFNs have effects on immune responses to bacterial infection. This review focuses on the immune regulation of type I IFN-mediated signal pathways in bacterial infections such as Listeria monocytogenes, Streptococcus, Mycobacterium tuberculosis, Bacillus anthracis, Legionella, Pseudomonas aeruginosa and others.
authors.affiliation: Department of Respiratory Medicine, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310009, China.
authors.forename: Ran
authors.initials: R
authors.lastname: Diao
authors.forename: Feng
authors.initials: F
authors.lastname: Xu
authors.forename: Xuan-ding
authors.initials: XD
authors.lastname: Wang
mesh_terms: D000818:Animals; D001424:Bacterial Infections / Q000276:immunology*; D006801:Humans; D007113:Immunity, Innate; D007370:Interferon Type I / Q000276:immunology*; D015398:Signal Transduction
chemical_list: D007370:Interferon Type I