title: Paroxetine use during pregnancy and perinatal outcomes including types of cardiac malformations in Quebec and France: a short communication.
abstract: BACKGROUND
  Antidepressants, more specifically SSRIs, represent one example of a widely prescribed class of medications in pregnant women for which less than adequate pregnancy data have been available since the first drug in this class was marketed 20 years ago. Moreover, findings from studies performed after 2005, when health governmental authorities issued warnings regarding first trimester exposure to paroxetine and the risk of cardiac malformations, may be the result of detection bias if physicians were investigating more their pregnant patients that used paroxetine than the others.
  
  
  OBJECTIVE
  To estimate the prevalence of 1) paroxetine use during pregnancy, and 2) diagnosed cardiac malformations in the Quebec and France populations.
  
  
  METHODS
  Two distinct pregnancy databases were used for this ecologic study: the Quebec Pregnancy Registry and the French EFEMERIS database.
  
  
  RESULTS
  In Quebec, among the 109,344 eligible pregnancies, 1,612 (1.5%) were exposed to paroxetine. Prevalence of paroxetine use during pregnancy increased from 0.7% to 1.2% between 1998 and 2003, simultaneously to the increase of the prevalence of cardiac malformation diagnoses. In France, among 40,317 eligible pregnancies, 173 (0.4%) were exposed to paroxetine; between 2004 and 2008 the number of paroxetine fillings and cardiac malformation diagnoses remained constant.
  
  
  CONCLUSIONS
  Despite differences in the Quebec and French healthcare systems, increase in paroxetine prevalence use during pregnancy was already consistent with an increase in the prevalence of cardiac malformations, even before the warning on the risk of cardiac malformations in newborns in 2005-2006, limiting the possibility of detection bias.
authors.affiliation: Faculty of Pharmacy, University of Montreal, Quebec, Canada. anick.berard@umontreal.ca
authors.forename: Anick
authors.initials: A
authors.lastname: Bérard
authors.forename: Odile
authors.initials: O
authors.lastname: Sheehy
authors.forename: Christine
authors.initials: C
authors.lastname: Damase-Michel
authors.forename: Sophie
authors.initials: S
authors.lastname: Crespin
mesh_terms: D000014:Abnormalities, Drug-Induced / Q000453:epidemiology*; D018687:Antidepressive Agents, Second-Generation / Q000009:adverse effects*; D005260:Female; D005602:France / Q000453:epidemiology; D006330:Heart Defects, Congenital / Q000139:chemically induced*; D006801:Humans; D007231:Infant, Newborn; D017374:Paroxetine / Q000009:adverse effects*; D011247:Pregnancy; D015995:Prevalence; D011792:Quebec / Q000453:epidemiology
chemical_list: D018687:Antidepressive Agents, Second-Generation; D017374:Paroxetine