title: Nanodiamonds as platforms for biology and medicine.
abstract: Nanoparticles possess a wide range of exceptional properties applicable to biology and medicine. In particular, nanodiamonds (NDs) are being studied extensively because they possess unique characteristics that make them suitable as platforms for diagnostics and therapeutics. This carbon-based material (2-8 nm) is medically relevant because it unites several key properties necessary for clinical applications, such as stability and compatibility in biological environments, and scalability in production. Research by the Ho group and others has yielded ND particles with a variety of capabilities ranging from delivery of chemotherapeutic drugs to targeted labeling and uptake studies. In addition, encouraging new findings have demonstrated the ability for NDs to effectively treat chemoresistant tumors in vivo. In this review, we highlight the progress made toward bringing nanodiamonds from the bench to the bedside.
authors.affiliation: Department of Mechanical Engineering, Northwestern University, Evanston, IL, USA.
authors.forename: Han B
authors.initials: HB
authors.lastname: Man
authors.forename: Dean
authors.initials: D
authors.lastname: Ho
mesh_terms: D000818:Animals; D001695:Biology; D004195:Disease Models, Animal; D016503:Drug Delivery Systems; D006801:Humans; D058612:Nanodiamonds; D050997:Nanomedicine; D061848:Optical Imaging
chemical_list: D058612:Nanodiamonds