title: Primary multidrug-resistant tuberculosis and its control implications in the State of Amazonas, Brazil: report of 3 cases.
abstract: The occurrence of tuberculosis with first-line multidrug resistance leads to the use of alternative medications, often at higher costs, longer treatment periods, and greater clinical complexity. Here, we report 3 patients with multidrug-resistant tuberculosis. One patient with human immunodeficiency virus died before the sensitivity test was performed. The early diagnosis of multidrug-resistant tuberculosis and appropriate treatment should be priorities of the National Tuberculosis Control Program in order to break the chain of transmission. In addition, the possibility of substituting the proportion method with more modern and faster techniques should be urgently evaluated.
authors.affiliation: Programa de Pós-Graduação em Medicina Tropical, Fundação de Medicina Tropical Dr. Heitor Vieira Dourado, Universidade do Estado do Amazonas, Manaus, AM, Brasil. marlucia.garrido@gmail.com
authors.forename: Marlucia Silva
authors.initials: MS
authors.lastname: Garrido
authors.forename: Anette Chrusciak
authors.initials: AC
authors.lastname: Talhari
authors.forename: Irineide Assumpção
authors.initials: IA
authors.lastname: Antunes
authors.forename: Joycenea da Silva
authors.initials: Jda S
authors.lastname: Matsuda
authors.forename: Etelvina das Graças
authors.initials: Ed
authors.lastname: Zaranza
authors.forename: Flor Ernestina
authors.initials: FE
authors.lastname: Martinez-Espinosa
authors.forename: Samira
authors.initials: S
authors.lastname: Bührer-Sékula
mesh_terms: D017088:AIDS-Related Opportunistic Infections / Q000175:diagnosis / Q000188:drug therapy; D000328:Adult; D000995:Antitubercular Agents / Q000627:therapeutic use*; D017809:Fatal Outcome; D006801:Humans; D008297:Male; D018088:Tuberculosis, Multidrug-Resistant / Q000175:diagnosis* / Q000188:drug therapy; D014397:Tuberculosis, Pulmonary / Q000175:diagnosis* / Q000188:drug therapy; D055815:Young Adult
chemical_list: D000995:Antitubercular Agents