title: Use of xylitol to enhance the therapeutic efficacy of polymethylmethacrylate-based antibiotic therapy in treatment of chronic osteomyelitis.
abstract: Using a rabbit model of postsurgical osteomyelitis, we demonstrate that incorporation of xylitol into polymethylmethacrylate (PMMA) bone cement enhances the elution of daptomycin under in vivo conditions. We also demonstrate that this can be correlated with an improved therapeutic outcome in the treatment of a chronic bone infection following surgical debridement.
authors.affiliation: Department of Microbiology and Immunology, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA.
authors.forename: Karen E
authors.initials: KE
authors.lastname: Beenken
authors.forename: Laura
authors.initials: L
authors.lastname: Bradney
authors.forename: William
authors.initials: W
authors.lastname: Bellamy
authors.forename: Robert A
authors.initials: RA
authors.lastname: Skinner
authors.forename: Sandra G
authors.initials: SG
authors.lastname: McLaren
authors.forename: M Johannes
authors.initials: MJ
authors.lastname: Gruenwald
authors.forename: Horace J
authors.initials: HJ
authors.lastname: Spencer
authors.forename: James K
authors.initials: JK
authors.lastname: Smith
authors.forename: Warren O
authors.initials: WO
authors.lastname: Haggard
authors.forename: Mark S
authors.initials: MS
authors.lastname: Smeltzer
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001843:Bone Cements / Q000627:therapeutic use; D002908:Chronic Disease; D017576:Daptomycin / Q000494:pharmacology*; D003646:Debridement; D003692:Delayed-Action Preparations / Q000737:chemistry / Q000494:pharmacology*; D004195:Disease Models, Animal; D006801:Humans; D008297:Male; D010019:Osteomyelitis / Q000188:drug therapy* / Q000382:microbiology / Q000601:surgery; D019904:Polymethyl Methacrylate / Q000737:chemistry*; D011817:Rabbits; D013203:Staphylococcal Infections / Q000188:drug therapy* / Q000382:microbiology / Q000601:surgery; D013211:Staphylococcus aureus / Q000187:drug effects / Q000254:growth & development; D014993:Xylitol / Q000737:chemistry*
chemical_list: D000900:Anti-Bacterial Agents; D001843:Bone Cements; D003692:Delayed-Action Preparations; D019904:Polymethyl Methacrylate; D017576:Daptomycin; D014993:Xylitol