title: Adenosine and autism: a spectrum of opportunities.
abstract: In rodents, insufficient adenosine produces behavioral and physiological symptoms consistent with several comorbidities of autism. In rodents and humans, stimuli postulated to increase adenosine can ameliorate these comorbidities. Because adenosine is a broad homeostatic regulator of cell function and nervous system activity, increasing adenosine's influence might be a new therapeutic target for autism with multiple beneficial effects. This article is part of the Special Issue entitled 'Neurodevelopmental Disorders'.
authors.affiliation: Neuroscience Program, Trinity College, 300 Summit St., Life Sciences Center, Hartford, CT 06106, USA. susan.masino@trincoll.edu
authors.forename: Susan A
authors.initials: SA
authors.lastname: Masino
authors.forename: Masahito
authors.initials: M
authors.lastname: Kawamura
authors.forename: Jessica L
authors.initials: JL
authors.lastname: Cote
authors.forename: Rebecca B
authors.initials: RB
authors.lastname: Williams
authors.forename: David N
authors.initials: DN
authors.lastname: Ruskin
mesh_terms: D000241:Adenosine / Q000378:metabolism*; D000818:Animals; D001321:Autistic Disorder / Q000378:metabolism*; D006801:Humans
chemical_list: D000241:Adenosine