title: Bisphosphonates use in children.
abstract: Bisphosphonates are synthetic analogues of pyrophosphate that inhibit bone resorption by their action on osteoclasts. In recent years, bisphosphonates have been used in children for treatment of a growing number of disorders associated primarily with generalized or localized osteoporosis, genetic and acquired metabolic bone diseases, heterotopic calcifications in soft tissues, and for hypercalcemia. In this review, the authors address the role of and experience with bisphosphonate therapy in disorders of childhood.
authors.affiliation: University of Missouri at Kansas City, Kansas City, MO, USA.
authors.forename: Judith F
authors.initials: JF
authors.lastname: Sebestyen
authors.forename: Tarak
authors.initials: T
authors.lastname: Srivastava
authors.forename: Uri S
authors.initials: US
authors.lastname: Alon
mesh_terms: D015502:Absorptiometry, Photon / Q000379:methods; D015519:Bone Density / Q000187:drug effects; D001851:Bone Diseases, Metabolic / Q000188:drug therapy*; D001862:Bone Resorption / Q000188:drug therapy*; D002648:Child; D002986:Clinical Trials as Topic; D004164:Diphosphonates / Q000008:administration & dosage* / Q000009:adverse effects / Q000494:pharmacology; D019317:Evidence-Based Medicine; D006801:Humans; D006934:Hypercalcemia / Q000188:drug therapy*; D010010:Osteoclasts / Q000187:drug effects*; D010024:Osteoporosis / Q000188:drug therapy; D016896:Treatment Outcome
chemical_list: D004164:Diphosphonates