title: Electrosprayed polyelectrolyte complexes between mucoadhesive N,N,N,-trimethylchitosan-homocysteine thiolactone and alginate/carrageenan for camptothecin delivery.
abstract: Novel hydrogel polyelectrolyte complexes (PECs) between the N,N,N,-trimethylchitosan-homocysteine thiolactone (TM-HT-chitosan) and two anionic polymers were investigated. The particles of pure thiolated chitosan and its PECs with alginate and carrageenan were fabricated using the electrospray ionization technique. The hydrogel PEC particles were characterized by scanning electron microscopy, dynamic light scattering, Fourier transform infrared microscopy, thermogravimetric analysis, encapsulation efficiency (EE), mucoadhesive property and in vitro drug release behavior. TM-HT-chitosan/alginate particles could be loaded with camptothecin (CPT), employed as a model anti-cancer drug, at an over 70% EE, and revealed both a reduced burst effect and a prolonged release of CPT over 3 days. The resultant TM-HT-chitosan/alginate PEC particles displayed a 5.60-, 1.86- and 1.55-fold stronger mucoadhesive property compared to that of the unmodified chitosan/alginate PEC at pH 1.2, 4.0 and 6.4, respectively, and this was not affected by the CPT loading level.
authors.affiliation: Program of Petrochemistry and Polymer Science, Faculty of Science, Chulalongkorn University, 254 Phayathai Road, Pathumwan, Bangkok 10330, Thailand.
authors.forename: Kotchakorn
authors.initials: K
authors.lastname: Juntapram
authors.forename: Nalena
authors.initials: N
authors.lastname: Praphairaksit
authors.forename: Kritsana
authors.initials: K
authors.lastname: Siraleartmukul
authors.forename: Nongnuj
authors.initials: N
authors.lastname: Muangsin
mesh_terms: D000464:Alginates / Q000737:chemistry*; D000972:Antineoplastic Agents, Phytogenic / Q000008:administration & dosage; D002166:Camptothecin / Q000008:administration & dosage*; D002351:Carrageenan / Q000737:chemistry*; D048271:Chitosan / Q000737:chemistry*; D004337:Drug Carriers; D016503:Drug Delivery Systems; D055664:Electrochemical Techniques / Q000379:methods; D020723:Glucuronic Acid / Q000737:chemistry; D006603:Hexuronic Acids / Q000737:chemistry; D006710:Homocysteine / Q000031:analogs & derivatives* / Q000737:chemistry; D008855:Microscopy, Electron, Scanning; D009077:Mucins / Q000187:drug effects* / Q000378:metabolism; D011108:Polymers / Q000737:chemistry*; D017550:Spectroscopy, Fourier Transform Infrared; D014014:Tissue Adhesives
chemical_list: D000464:Alginates; D000972:Antineoplastic Agents, Phytogenic; D004337:Drug Carriers; D006603:Hexuronic Acids; D009077:Mucins; C118071:N-trimethyl chitosan chloride; D011108:Polymers; D014014:Tissue Adhesives; D006710:Homocysteine; D020723:Glucuronic Acid; D002351:Carrageenan; D048271:Chitosan; C007957:homocysteine thiolactone; D002166:Camptothecin