title: A chemoselective, one-pot transformation of aldehydes to nitriles.
abstract: This paper describes a procedure for direct conversion of aldehydes to nitriles using O-(diphenylphosphinyl)hydroxylamine (DPPH). Aldehydes are smoothly transformed to their corresponding nitriles by heating with DPPH in toluene. The reaction can be accomplished in the presence of alcohol, ketone, ester, or amine functionality.
authors.affiliation: Department of Chemistry, University of Louisville, Louisville, Kentucky 40292, USA.
authors.forename: Sébastien
authors.initials: S
authors.lastname: Laulhé
authors.forename: Sadakatali S
authors.initials: SS
authors.lastname: Gori
authors.forename: Michael H
authors.initials: MH
authors.lastname: Nantz
mesh_terms: D000447:Aldehydes / Q000737:chemistry*; D015394:Molecular Structure; D009570:Nitriles / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D000447:Aldehydes; D009570:Nitriles