title: [Use of regulatory T cells in cellular therapies in autoimmune diseases].
abstract: Self tolerance is dependent on regulatory T cells (Treg) which suppress effector T cells, avoiding autoimmunity. Functional and quantitative deficits of Treg have been reported in autoimmune diseases. A new therapeutic approach consisting in Treg adoptive transfer has proved to be efficient and safe in murine models. Two populations seem to be available for a clinical application: CD4(+)CD25(+)Foxp3(+) natural Treg derived from the thymus and induced regulatory T cells. First clinical trials have been applied to patients with autoimmune diseases. Classical treatments of autoimmune diseases are usually non-curative and require long-term administration. Treg cellular therapy may have a long-term effect and offers an alternative attractive approach.
authors.affiliation: UMPC Université Paris 6, Master sciences et technologies, mention biologie moléculaire et cellulaire, parcours immunotechnologies et biothérapies, Paris 6 (PRES Sorbonne Universités), 4, place Jussieu, 75005 Paris, France. gboursier@gmail.com
authors.forename: Guilaine
authors.initials: G
authors.lastname: Boursier
authors.forename: Aurélie
authors.initials: A
authors.lastname: Siri
authors.forename: Hubert
authors.initials: H
authors.lastname: de Boysson
mesh_terms: D000818:Animals; D001327:Autoimmune Diseases / Q000276:immunology / Q000628:therapy*; D002478:Cells, Cultured / Q000276:immunology / Q000378:metabolism / Q000637:transplantation; D004195:Disease Models, Animal; D005544:Forecasting; D041722:Genes, Transgenic, Suicide; D006801:Humans; D007108:Immune Tolerance; D016219:Immunotherapy, Adoptive; D016753:Interleukin-10 / Q000378:metabolism; D008180:Lupus Erythematosus, Systemic / Q000276:immunology / Q000628:therapy; D051379:Mice; D018979:Myositis, Inclusion Body / Q000276:immunology / Q000628:therapy; D057285:Precision Medicine; D050378:T-Lymphocytes, Regulatory / Q000276:immunology / Q000378:metabolism / Q000637:transplantation*; D014182:Transplantation, Autologous; D014605:Uveitis / Q000276:immunology / Q000628:therapy
chemical_list: C508609:IL10 protein, human; D016753:Interleukin-10