title: A role for vimentin in Crohn disease.
abstract: Crohn disease (CD), one of the major chronic inflammatory bowel diseases, occurs anywhere in the gastrointestinal tract with discontinuous transmural inflammation. A number of studies have now demonstrated that genetic predisposition, environmental influences and a dysregulated immune response to the intestinal microflora are involved. Major CD susceptibility pathways uncovered through genome-wide association studies strongly implicate the innate immune response (NOD2), in addition to the more specific acquired T cell response (IL23R, ICOSLG) and autophagy (ATG16L1, IRGM). Examination of the disease-associated microbiome, although complex, has identified several potentially contributory microorganisms, most notably adherent-invasive E.coli strains (AIEC), which have been isolated by independent investigators in both adult and pediatric CD patients. Here we discuss our recent finding that the type-III intermediate filament (IF) protein VIM/vimentin is a novel NOD2 interacting protein that regulates NOD2 activities including inflammatory NFKB1 signaling, autophagy and bacterial handling.
authors.affiliation: Department of Child Life and Health, University of Edinburgh, Edinburgh, UK.
authors.forename: Paul
authors.initials: P
authors.lastname: Henderson
authors.forename: David C
authors.initials: DC
authors.lastname: Wilson
authors.forename: Jack
authors.initials: J
authors.lastname: Satsangi
authors.forename: Craig
authors.initials: C
authors.lastname: Stevens
mesh_terms: D001343:Autophagy; D003424:Crohn Disease / Q000378:metabolism* / Q000382:microbiology / Q000473:pathology*; D004926:Escherichia coli; D006801:Humans; D008954:Models, Biological; D053473:Nod2 Signaling Adaptor Protein / Q000378:metabolism; D015398:Signal Transduction; D014746:Vimentin / Q000378:metabolism*
chemical_list: D053473:Nod2 Signaling Adaptor Protein; D014746:Vimentin