title: Prenatal findings of omphalocele-exstrophy of the bladder-imperforate anus-spinal defects (OEIS) complex.
abstract: Omphalocele-exstrophy of the bladder (cloaca)-imperforate anus-spinal defects (OEIS) complex describes a rare grouping of more commonly occurring component malformations. We report two cases of OEIS complex diagnosed prenatally by ultrasound and magnetic resonance imaging (MRI). In both cases, OEIS complex was suspected by conventional sonography in the second trimester, and fetal MRI was performed at 27 and 32 weeks of gestation. Conventional sonography revealed low abdominal wall mass, spina bifida, absent bladder and ambiguous genitalia, but those findings were inconclusive. Using fetal MRI, we were able to detect omphalocele, imfraumbilical mass connected to gut tract, absent bladder, ambiguous external genitalia and spinal defect. Our findings suggest that fetal MRI is a useful tool for prenatal diagnosis of OEIS complex. MRI helps prenatal counseling and planning of postnatal early treatment strategy.
authors.affiliation: Department of Obstetrics and Gynecology             Division of Clinical and Molecular Genetics, Nagoya City University Graduate School of Medicine, Nagoya, Japan.
authors.forename: Shinobu
authors.initials: S
authors.lastname: Goto
authors.forename: Nobuhiro
authors.initials: N
authors.lastname: Suzumori
authors.forename: Shintaro
authors.initials: S
authors.lastname: Obayashi
authors.forename: Eita
authors.initials: E
authors.lastname: Mizutani
authors.forename: Yuko
authors.initials: Y
authors.lastname: Hayashi
authors.forename: Mayumi
authors.initials: M
authors.lastname: Sugiura-Ogasawara
mesh_terms: D000015:Abnormalities, Multiple / Q000175:diagnosis*; D000328:Adult; D001006:Anus, Imperforate / Q000175:diagnosis*; D001746:Bladder Exstrophy / Q000175:diagnosis*; D006554:Hernia, Umbilical / Q000175:diagnosis*; D006801:Humans; D012600:Scoliosis / Q000175:diagnosis*; D016135:Spinal Dysraphism / Q000175:diagnosis*; D016216:Ultrasonography, Prenatal; D014564:Urogenital Abnormalities / Q000175:diagnosis*; D000099061:OEIS Complex