title: A personalized life: biomarker monitoring from cradle to grave.
abstract: Considering the holy grail of future medical treatment being personalized medicines, biomarker research will become more and more the focus for attention not only to develop new medical treatment regimes, based on changes in biomarker patterns, but also for nutritional advice to guarantee a lifelong optimized health condition. The current review gives an outline of how personalized medicine can become established for actual medical treatment using new biomarker concepts. Starting from the development of biomarker research using mainly immunological techniques, the review gives an overview about biomarkers of prediction evolved and focuses on new methodology for the identification of biomarkers using hyphenated analytical techniques like metabolomics and lipidomics. The actual use of multivariate statistical methods in combination with metabolomics and lipidomics is discussed not only for medical treatment but also for precautionary risk identification in human biomonitoring studies.
authors.affiliation: Department of Product Safety, German Federal Institute for Risk Assessment (BfR), Max-Dohrn-Strasse 8-10, 10589, Berlin, Gemany, Harald.Jungnickel@bfr.bund.de.
authors.forename: Harald
authors.initials: H
authors.lastname: Jungnickel
authors.forename: Andreas
authors.initials: A
authors.lastname: Luch
mesh_terms: D015415:Biomarkers; D004784:Environmental Monitoring; D006801:Humans; D050356:Lipid Metabolism; D055432:Metabolomics; D057285:Precision Medicine
chemical_list: D015415:Biomarkers