title: Identification of 1-butyl-3-(1-(4-methyl)naphtoyl)indole detected for the first time in "herbal high" products on the Italian market.
abstract: The results of the analysis of some herbal products and powders adulterated with alkylindoles recovered on the Italian market between 2010 and 2011 are reported. Besides the well-known alkyindoles JWH-018 and JWH-073, other derivatives such as JWH-250 and AM-694 have been detected and for the first time in Italy 1-butyl-3-(1-(4-methyl)naphthoyl)indole (compound 1), the 4-methylnaphthoyl analogue of JWH-073. This compound as well as the other alkylindoles has been synthesized and characterized by (1)H NMR, (13)C NMR, DSC, GC/MS, and elemental analysis. The quantitative analyses of the samples have been carried out by means of the GC/FID method developed in our laboratory for the analysis of herbal high products containing naphthoylindoles; the quantity of the cannabimimetic substances ranged from 6 mg/g to 47 mg/g.
authors.affiliation: Dipartimento di Scienze Farmaceutiche Pietro Pratesi, Università degli Studi di Milano, via Mangiagalli 25, I-20133 Milano, Italy.
authors.forename: Ermanno
authors.initials: E
authors.lastname: Valoti
authors.forename: Eleonora
authors.initials: E
authors.lastname: Casagni
authors.forename: Lucia
authors.initials: L
authors.lastname: Dell'Acqua
authors.forename: Marco
authors.initials: M
authors.lastname: Pallavicini
authors.forename: Gabriella
authors.initials: G
authors.lastname: Roda
authors.forename: Chiara
authors.initials: C
authors.lastname: Rusconi
authors.forename: Valentina
authors.initials: V
authors.lastname: Straniero
authors.forename: Veniero
authors.initials: V
authors.lastname: Gambaro