title: Antimicrobial aflatoxins from the marine-derived fungus Aspergillus flavus 092008.
abstract: A new aflatoxin, aflatoxin B(2b) (1), together with six known compounds, were isolated from the marine-derived fungus Aspergillus flavus 092008 endogenous with the mangrove plant Hibiscus tiliaceus (Malvaceae). The structure of 1 was determined by the spectroscopic and chemical methods. Compound 1 exhibited a moderate antimicrobial activity against Escherichia coli, Bacillus subtilis and Enterobacter aerogenes, with MIC values of 22.5, 1.7 and 1.1 M, respectively. Compound 1 also showed a weak cytotoxicity against A549, K562 and L-02 cell lines, with IC(50) values of 8.1, 2.0 and 4.2 M, respectively. The results showed that hydration and hydrogenation of (8)-double bond significantly reduces the cytotoxicity of aflatoxins, while the esterification at C-8 increases the cytotoxicity.
authors.affiliation: Key laboratory of Marine Drugs, Ministry of Education of China, School of Medicine and Pharmacy, Ocean University of China, Qingdao, 266003, China.
authors.forename: Hui
authors.initials: H
authors.lastname: Wang
authors.forename: Zhenyu
authors.initials: Z
authors.lastname: Lu
authors.forename: Hai-Jun
authors.initials: HJ
authors.lastname: Qu
authors.forename: Peipei
authors.initials: P
authors.lastname: Liu
authors.forename: Chengdu
authors.initials: C
authors.lastname: Miao
authors.forename: Tonghan
authors.initials: T
authors.lastname: Zhu
authors.forename: Jing
authors.initials: J
authors.lastname: Li
authors.forename: Kui
authors.initials: K
authors.lastname: Hong
authors.forename: Weiming
authors.initials: W
authors.lastname: Zhu
mesh_terms: D000348:Aflatoxins / Q000008:administration & dosage / Q000302:isolation & purification / Q000494:pharmacology*; D000890:Anti-Infective Agents / Q000008:administration & dosage / Q000302:isolation & purification / Q000494:pharmacology; D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000302:isolation & purification / Q000494:pharmacology*; D001231:Aspergillus flavus / Q000737:chemistry* / Q000302:isolation & purification; D001412:Bacillus subtilis / Q000187:drug effects; D045744:Cell Line, Tumor; D021902:Enterobacter aerogenes / Q000187:drug effects; D004926:Escherichia coli / Q000187:drug effects; D031584:Hibiscus / Q000382:microbiology*; D006801:Humans; D020128:Inhibitory Concentration 50; D020014:K562 Cells; D008826:Microbial Sensitivity Tests
chemical_list: D000348:Aflatoxins; D000890:Anti-Infective Agents; D000970:Antineoplastic Agents