title: Cardiac obstruction secondary to metastatic invasion - A rare complication of Human Herpes Virus 8-positive plasmablastic lymphoma in acquired immunodeficiency syndrome.
abstract: Human herpes virus 8 (HHV8)-positive plasmablastic lymphoma (PBL) is a particularly rare and aggressive subtype of non-Hodgkin lymphoma, strongly associated with human immunodeficiency virus infection, with poor response to therapy and short survival. Characteristically, it shows proliferation of large plasmablastic cells with often eccentrically placed nuclei, with immunohistochemical assay positive for HHV8 latent nuclear antigen 1 and IgM. Primary mediastinal occurrence of a HHV8-positive PBL is rare and metastatic disease even more uncommon; tumor invasion to the heart leading to intracardiac obstruction with a rapidly fatal disease course has not been previously described.
authors.forename: Daniele
authors.initials: D
authors.lastname: Pádua
authors.forename: Ana Clara
authors.initials: AC
authors.lastname: Rodrigues
authors.forename: Sérgio
authors.initials: S
authors.lastname: Barros
authors.forename: Ana Lúcia
authors.initials: AL
authors.lastname: Arruda
authors.forename: Marianne
authors.initials: M
authors.lastname: Castro
authors.forename: José Lázaro
authors.initials: JL
authors.lastname: Andrade