title: Rapid construction of the [6-6-6-5] tetracyclic skeleton of the Daphniphyllum alkaloid daphenylline.
abstract: You can call me Al: A concise route for construction of the [6-6-6-5] tetracyclic skeleton of daphenylline, a structurally novel Daphniphyllum alkaloid, has been developed with full stereocontrol in only 8 steps from two known fragments. This approach features an intramolecular [3+2] cycloaddition of a 2-azaallyl anion with an alkene to form the cis-fused AC rings.
authors.affiliation: State Key Laboratory of Applied Organic Chemistry, Department of Chemistry, Lanzhou University, 222 South Tianshui Road, Lanzhou, 730000, PR China.
authors.forename: Huilin
authors.initials: H
authors.lastname: Li
authors.forename: Jiyue
authors.initials: J
authors.lastname: Zheng
authors.forename: Shiyan
authors.initials: S
authors.lastname: Xu
authors.forename: Donghui
authors.initials: D
authors.lastname: Ma
authors.forename: Changgui
authors.initials: C
authors.lastname: Zhao
authors.forename: Bowen
authors.initials: B
authors.lastname: Fang
authors.forename: Xingang
authors.initials: X
authors.lastname: Xie
authors.forename: Xuegong
authors.initials: X
authors.lastname: She
mesh_terms: D000470:Alkaloids / Q000138:chemical synthesis / Q000737:chemistry*; D000475:Alkenes / Q000737:chemistry; D061565:Cycloaddition Reaction; D019669:Embryophyta / Q000737:chemistry*
chemical_list: D000470:Alkaloids; D000475:Alkenes; C541594:daphenylline