title: The local infiltration of analgesia following total knee replacement: a review of current literature.
abstract: Controversy remains regarding the optimal post-operative   analgesic regimen following total knee replacement. A delicate balance   is required between the provision of adequate pain relief and early   mobilisation. By reviewing 29 randomised trials we sought to establish   whether local infiltration of analgesia directly into the knee during   surgery provides better pain relief and a more rapid rehabilitation.   Although we were able to conclude that local infiltration can provide   improved post-operative pain relief, and to suggest the most promising   technique of administration, there is no evidence that it reduces   hospital stay.
authors.affiliation: Leicester General Hospital, Gwendolen Road, Leicester LE5 4PW, UK. dmrgibbs@yahoo.co.uk
authors.forename: D M R
authors.initials: DM
authors.lastname: Gibbs
authors.forename: T P
authors.initials: TP
authors.lastname: Green
authors.forename: C N
authors.initials: CN
authors.lastname: Esler
mesh_terms: D000284:Administration, Oral; D000698:Analgesia / Q000379:methods; D000700:Analgesics / Q000008:administration & dosage*; D000772:Anesthesia, Local / Q000379:methods; D019645:Arthroplasty, Replacement, Knee / Q000009:adverse effects*; D004359:Drug Therapy, Combination; D004434:Early Ambulation; D006801:Humans; D055104:Infusions, Subcutaneous; D007270:Injections, Intra-Articular; D007902:Length of Stay; D009407:Nerve Block; D059408:Pain Management; D010147:Pain Measurement; D010149:Postoperative Pain / Q000209:etiology / Q000517:prevention & control*
chemical_list: D000700:Analgesics