title: Phenylpropene diglycosides from the bark of Machilus wangchiana.
abstract: Five new phenylpropene diglycosides (1-5), together with three known analogs, have been isolated from an ethanol extract of the bark of Machilus wangchiana. Their structures were determined by spectroscopic and chemical methods. In the preliminary assay, compounds 2 and 5-8 reduced dl-galactosamine (GalN)-induced hepatocyte (WB-F344 cells) damage with 37-41% inhibitions at 10 μM.
authors.affiliation: State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100050, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Cheng
authors.forename: Cheng-Gen
authors.initials: CG
authors.lastname: Zhu
authors.forename: Wen-Dong
authors.initials: WD
authors.lastname: Xu
authors.forename: Xiao-Na
authors.initials: XN
authors.lastname: Fan
authors.forename: Yong-Chun
authors.initials: YC
authors.lastname: Yang
authors.forename: Yan
authors.initials: Y
authors.lastname: Li
authors.forename: Jian-Gong
authors.initials: JG
authors.lastname: Shi
mesh_terms: D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D006027:Glycosides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D022781:Hepatocytes / Q000187:drug effects; D019770:Lauraceae / Q000737:chemistry*; D015394:Molecular Structure; D024301:Plant Bark / Q000737:chemistry; D011427:Propiophenones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology
chemical_list: D004365:Drugs, Chinese Herbal; D006027:Glycosides; D011427:Propiophenones