title: Enmein-type diterpenoids from the aerial parts of Isodon rubescens and their cytotoxicity.
abstract: Three new enmein-type diterpenoids, jianshirubesins A-C (1-3), together with ten known compounds, were isolated from the aerial parts of Isodon rubescens. Their structures were established by using spectroscopic methods, and the absolute configuration of compound 1 was confirmed by a single-crystal X-ray diffraction analysis. All compounds except 3 were evaluated for their in vitro cytotoxicity by MTT assay, and compounds 5 and 10 exhibited significant inhibitory ability on selected cell lines.
authors.affiliation: Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, Tongji School of Pharmacy, Huazhong University of Science and Technology, Wuhan 430030, Hubei, People's Republic of China.
authors.forename: Xu
authors.initials: X
authors.lastname: Liu
authors.forename: Wei-Guang
authors.initials: WG
authors.lastname: Wang
authors.forename: Xue
authors.initials: X
authors.lastname: Du
authors.forename: Xiao-Nian
authors.initials: XN
authors.lastname: Li
authors.forename: Ling-Mei
authors.initials: LM
authors.lastname: Kong
authors.forename: Yan
authors.initials: Y
authors.lastname: Li
authors.forename: Jian-Xin
authors.initials: JX
authors.lastname: Pu
authors.forename: Ji-Zhou
authors.initials: JZ
authors.lastname: Wu
authors.forename: Han-Dong
authors.initials: HD
authors.lastname: Sun
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry* / Q000494:pharmacology*; D045744:Cell Line, Tumor; D004224:Diterpenes / Q000737:chemistry* / Q000494:pharmacology*; D006801:Humans; D037602:Isodon / Q000737:chemistry*; D008958:Models, Molecular; D015394:Molecular Structure; D035261:Plant Components, Aerial / Q000737:chemistry
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D004224:Diterpenes; C007594:enmein