title: Effect of Helicobacter pylori on marginal ulcer and stomal stenosis after Roux-en-Y gastric bypass.
abstract: BACKGROUND
  Conflicting data have been published regarding whether Helicobacter pylori (HP) positivity is associated with increased complication rates in patients undergoing Roux-en-Y gastric bypass (RYGB).
  
  
  METHODS
  We retrospectively examined the rate of complications in patients undergoing RYGB according to preoperative HP positivity and persistent post-treatment positivity to determine whether a correlation exists.
  
  
  RESULTS
  A total of 228 patients underwent RYGB during a 2-year period (2009-2011). No patient had evidence of active ulcer disease on preoperative endoscopy. Of the 228 patients, 68 tested positive for HP on serum antigen screening and were treated with omeprazole, clarithromycin, and amoxillin. After treatment, 24 patients were persistently positive on repeat endoscopic biopsy. Of the 228 patients, 12 experienced a total of 13 complications (stomal stenosis in 8, marginal ulcer in 5, and none with anastomotic leak or gastrointestinal bleeding). Of the 68 patients with HP positivity preoperatively, 1 complication (2.3%) developed in the 44 patients who had responded to triple therapy, and no complications occurred in the 24 patients who had remained positive after treatment (P = 1.00), showing no difference. Also, no significant difference was found in the rate of complications (P = .11) between patients who were HP negative preoperatively (11 of 160, 6.9%) and those who were positive preoperatively (1 of 68, 1.5%).
  
  
  CONCLUSIONS
  HP status, whether positive preoperatively or persistently positive after treatment, had no effect on the marginal ulcer or stomal stenosis rates in patients undergoing RYGB in the present study.
authors.affiliation: Wright State University, General Surgery, Dayton, Ohio. Electronic address: rawlinml@yahoo.com.
authors.forename: Logan
authors.initials: L
authors.lastname: Rawlins
authors.forename: Melissa P
authors.initials: MP
authors.lastname: Rawlins
authors.forename: Carey C
authors.initials: CC
authors.lastname: Brown
authors.forename: David L
authors.initials: DL
authors.lastname: Schumacher
mesh_terms: D000328:Adult; D000890:Anti-Infective Agents / Q000627:therapeutic use; D001706:Biopsy; D003251:Constriction, Pathologic / Q000382:microbiology; D005260:Female; D015390:Gastric Bypass / Q000379:methods*; D016481:Helicobacter Infections / Q000150:complications* / Q000188:drug therapy; D016480:Helicobacter pylori; D006801:Humans; D008297:Male; D009767:Obesity, Morbid / Q000601:surgery*; D010437:Peptic Ulcer / Q000382:microbiology*; D011183:Postoperative Complications / Q000382:microbiology*; D012189:Retrospective Studies; D054047:Surgical Stomas / Q000382:microbiology*
chemical_list: D000890:Anti-Infective Agents