title: Use of intravenous acetaminophen (paracetamol) in a pediatric patient at the end of life: case report.
abstract: BACKGROUND
  For the better part of 100 years, acetaminophen (or paracetamol as it is known outside of the United States) has been a common first-line analgesic in pediatrics and is typically well tolerated with minimal side effects. Its use as an anti-pyretic is also well-documented and thus it is used broadly for symptom control in the general pediatric population.
  
  
  CONCLUSIONS
  In pediatric palliative care, acetaminophen is also used as an adjuvant to opioid therapy for pain as well as an anti-pyretic. For many pediatric patients near end-of-life, however, the ability to tolerate oral intake is diminished and rectal suppository administration can be distressing or contraindicated as in the setting of neutropenia, thus limiting use of acetaminophen by its usual routes. In Europe and Australia, an intravenous formulation of acetaminophen has been used for many years and has only recently become available in the United States.
  
  
  CONCLUSIONS
  Here, we describe a case using intravenous acetaminophen in a pediatric patient at the end of life.
authors.affiliation: 1 Department of Internal Medicine, University of Michigan , Ann Arbor, Michigan.
authors.forename: Adam D
authors.initials: AD
authors.lastname: Marks
authors.forename: Patricia
authors.initials: P
authors.lastname: Keefer
authors.forename: D'Anna
authors.initials: D
authors.lastname: Saul
mesh_terms: D000082:Acetaminophen / Q000008:administration & dosage*; D018712:Analgesics, Non-Narcotic / Q000008:administration & dosage*; D002648:Child; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D007275:Injections, Intravenous; D010051:Ovarian Neoplasms / Q000473:pathology; D010146:Pain / Q000188:drug therapy*; D018310:Sertoli-Leydig Cell Tumor / Q000473:pathology; D013727:Terminal Care
chemical_list: D018712:Analgesics, Non-Narcotic; D000082:Acetaminophen