title: Analysis of peripheral artery velocity tracing in a porcine model.
abstract: BACKGROUND
  The aim of the study was to trace the peripheral artery velocity with ultrasound in pigs and provide inference on diagnosis of the type, location and severity of vascular diseases.
  
  
  METHODS
  Limb tightening, adrenaline administration and arterial wall pinching were performed independently in six pigs, and then the evolution of the external iliac artery or femoral artery velocity tracing were monitored.
  
  
  RESULTS
  With the increase of the extents of hindlimb tightening, peak systolic velocity (PSV) of ipsilateral external iliac artery turned from 36.33±1.77 cm/s to 59.72±2.67 cm/s, minimum post-principal wave velocity (MPV from 13.68±1.11 cm/s to -7.48±0.82 cm/s, peak diastolic velocity (PDV) from 19.31±0.86 cm/s to 8.98±0.45 cm/s, and, end diastolic velocity (EDV) from 13.2±0.45 cm/s to 0. With the increase of the dose of the epinephrine injection, PSV increased from 36.33±1.77 cm/s to 43.97±2.15 cm/s but then decreased to 35.43±3.01 cm/s, and MPV negatively increased to -23.53±0.82 cm/s after decreasing from 13.68±1.11 cm/s to 0. PDV and EDV gradually decreased to zero. With the increase of the stenosis severity in the abdominal aortic wall pinching, PSV was reduced and had a linearly negative correlation with the stenosis severity (R=0.983, R2=0.967). MPV gradually increased, and its direction reversed when the stenosis severity increased, then diminished when the blood flow was occluded by more than 2/3.
  
  
  CONCLUSIONS
  The formation of peripheral artery velocity is the result of concurrent effects of cardiac ejection, vascular resistance, effective circulating blood volume and elastic recoil. Vascular resistance exerts pronounced effects on the diastolic waveform, and the occurrence of backward wave indicates that the downstream circulation resistance significantly increases.
authors.affiliation: Department of Ultrasound, Jinling Hospital, School of Medicine, Nanjing University, Nanjing, China.
authors.forename: Qingxin
authors.initials: Q
authors.lastname: Meng
authors.forename: Weiwei
authors.initials: W
authors.lastname: Ding
authors.forename: Bin
authors.initials: B
authors.lastname: Yang
authors.forename: Ninghua
authors.initials: N
authors.lastname: Fu
authors.forename: Guangming
authors.initials: G
authors.lastname: Lu