title: One-pot gold-catalyzed synthesis of azepino[1,2-a]indoles.
abstract: Indoles from scratch: A gold(I)/N-heterocyclic carbene complex (IPr=1,3-di(isopropylphenyl)imidazol-2-ylidene) was found to be particularly effective as a catalyst, enabling the one-pot synthesis of tricyclic azepinoindoles by an unprecedented cascade reaction. Readily available substrates, high chemoselectivity, good yields, and water as the only stoichiometric by-product are some of the main advantages of this method.
authors.affiliation: Dipartimento di Chimica G. Ciamician, Alma Mater Studiorum-Università di Bologna, Bologna, Italy.
authors.forename: Gianpiero
authors.initials: G
authors.lastname: Cera
authors.forename: Stefano
authors.initials: S
authors.lastname: Piscitelli
authors.forename: Michel
authors.initials: M
authors.lastname: Chiarucci
authors.forename: Giancarlo
authors.initials: G
authors.lastname: Fabrizi
authors.forename: Antonella
authors.initials: A
authors.lastname: Goggiamani
authors.forename: Rubén S
authors.initials: RS
authors.lastname: Ramón
authors.forename: Steven P
authors.initials: SP
authors.lastname: Nolan
authors.forename: Marco
authors.initials: M
authors.lastname: Bandini
mesh_terms: D001381:Azepines / Q000138:chemical synthesis* / Q000737:chemistry; D002384:Catalysis; D007211:Indoles / Q000138:chemical synthesis* / Q000737:chemistry; D008697:Methane / Q000031:analogs & derivatives* / Q000737:chemistry; D050607:Organogold Compounds / Q000737:chemistry*
chemical_list: D001381:Azepines; D007211:Indoles; D050607:Organogold Compounds; C030011:carbene; D008697:Methane