title: [Clinical study of optic neuritis combined with viral hepatitis].
abstract: OBJECTIVE
  To investigate the clinical manifestation, management and prognosis of optic neuritis combined with viral hepatitis.
  
  
  METHODS
  Retrospective study case series. Clinical data from twenty patients with optic neuritis combined with hepatitis who were hospitalized in Beijing Tongren Hospital neural eye ward from September 2003 to June 2010 were collected, the clinical characteristics and visual field changes in the group of patients were summarized, and comparison between the vision before and after treatment was made by the Wingerchuk vision classification.
  
  
  RESULTS
  Among the twenty patients, eighteen patients had chronic hepatitis B and two patients had chronic hepatitis C. Thirteen (65%) patient were monocular, sixteen (80%) patients were single-phase course. Twenty-seven eyes were affected. Disc edema was very common which was found in 14 eyes (52%), severe vision impairment (Best corrected visual acuity worse than 20/200) were recorded in 19 eyes (70%). Lower altitudinal visual field impairment was more common which was found in 10 eyes (50%). All patients were followed for 3 months after steroid therapy, complete visual recovery or significant improvement was seen in only 3 eyes (11%) or 4 eyes (15%). Minor improvement was seen in 12 eyes (44%), while 8 eyes (30%) had no improvement.
  
  
  CONCLUSIONS
  In this study, optic neuritis combined with hepatitis usually showed severe visual impairment. Although the vision of some patients could completely recover after steroid therapy, most of the patients had poor recovery. Combination of steroid and anti-viral therapy should be considered in the management of optic neuritis combined with hepatitis.
authors.affiliation: Department of Neurology, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, China.
authors.forename: Li-ping
authors.initials: LP
authors.lastname: Zhu
authors.forename: Hai
authors.initials: H
authors.lastname: Lu
authors.forename: Rong
authors.initials: R
authors.lastname: Yan
authors.forename: Jing-ting
authors.initials: JT
authors.lastname: Peng
authors.forename: Chang-feng
authors.initials: CF
authors.lastname: Lu
authors.forename: Lin
authors.initials: L
authors.lastname: Sun
authors.forename: Xiao-jun
authors.initials: XJ
authors.lastname: Zhang
mesh_terms: D000328:Adult; D000998:Antiviral Agents / Q000627:therapeutic use; D005260:Female; D005938:Glucocorticoids / Q000627:therapeutic use; D006525:Hepatitis, Viral, Human / Q000150:complications* / Q000188:drug therapy*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009902:Optic Neuritis / Q000150:complications* / Q000188:drug therapy* / Q000821:virology; D012189:Retrospective Studies; D055815:Young Adult
chemical_list: D000998:Antiviral Agents; D005938:Glucocorticoids