title: Angiogenin in middle-aged type 1 diabetes patients.
abstract: BACKGROUND
  Angiogenin levels are increased in children and adolescent patients with type 1 diabetes, regardless of the extent of diabetic microangiopathy. However, little is known about the angiogenin concentrations in adults with type 1 diabetes. Thus we studied its level in middle aged subjects with the presence of diabetic nephro-, retino and neuropathy.
  
  
  METHODS
  We investigated the data of 57 (age 39±6.6 years, 45.6% of males) patients with type 1 diabetes and 38 age-matched control subjects without diabetes (age 37.1±5.9 years, 42.1% of males), including medical histories, evidences of microangiopathy and serum angiogenin concentrations.
  
  
  RESULTS
  Serum angiogenin level was lower in patients with type 1 diabetes [384.2(190.4-999.8) ng/ml] compared to controls [460.4(230.6-708.2) ng/ml], p=0.04. In patients with overt diabetic nephropathy the angiogenin level was higher when compared to patients without nephropathy [568.2(269.6-999.8) vs 369.4(190.4-999.8) ng/ml, p=0.01]. There were no differences between angiogenin levels in subgroups of patients distinguished by the presence of other microvascular complications or other concomitant vascular risk factors despite cigarette smoking [smokers: 516.2(294.4-999.8) vs. non-smokers: 372.1(190.4-924.8) ng/ml, p=0.01].
  
  
  CONCLUSIONS
  Regardless of the presence of diabetic microangiopathy, angiogenin level in middle-aged type 1 diabetes patients is lower than in controls. The presence of overt nephropathy and smoking habit in middle-aged patients with type 1 diabetes are associated with higher angiogenin level.
authors.affiliation: Department of Clinical Physiology, Medical University of Gdansk, Debinki 7 Street, 80-211 Gdansk, Poland. jolaneub@gumed.edu.pl
authors.forename: Jolanta
authors.initials: J
authors.lastname: Neubauer-Geryk
authors.forename: Grzegorz M
authors.initials: GM
authors.lastname: Kozera
authors.forename: Bogumil
authors.initials: B
authors.lastname: Wolnik
authors.forename: Sebastian
authors.initials: S
authors.lastname: Szczyrba
authors.forename: Walenty M
authors.initials: WM
authors.lastname: Nyka
authors.forename: Leszek
authors.initials: L
authors.lastname: Bieniaszewski
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D003922:Diabetes Mellitus, Type 1 / Q000097:blood*; D003928:Diabetic Nephropathies / Q000097:blood; D003929:Diabetic Neuropathies / Q000097:blood; D003930:Diabetic Retinopathy / Q000097:blood; D005260:Female; D005786:Gene Expression Regulation; D005919:Glomerular Filtration Rate; D006801:Humans; D008297:Male; D009389:Neovascularization, Pathologic; D012259:Ribonuclease, Pancreatic / Q000096:biosynthesis* / Q000097:blood
chemical_list: C046366:angiogenin; D012259:Ribonuclease, Pancreatic