title: Unified approach to catechin hetero-oligomers: first total synthesis of trimer EZ-EG-CA isolated from Ziziphus jujuba.
abstract: A catechin hetero-trimer isolated from Ziziphus jujuba has been synthesized. Among three constituent monomers, (-)-epiafzelechin and (-)-epigallocatechin were prepared by de novo synthesis. Trimer formation relied on the unified approach to oligomers based on the bromo-capping and the orthogonal activation, reaching the reported structure of the natural product.
authors.affiliation: Department of Chemistry, Tokyo Institute of Technology, O-okayama, Meguro-ku, Tokyo 152-8551, Japan.
authors.forename: Takahisa
authors.initials: T
authors.lastname: Yano
authors.forename: Ken
authors.initials: K
authors.lastname: Ohmori
authors.forename: Haruko
authors.initials: H
authors.lastname: Takahashi
authors.forename: Takenori
authors.initials: T
authors.lastname: Kusumi
authors.forename: Keisuke
authors.initials: K
authors.lastname: Suzuki
mesh_terms: D002392:Catechin / Q000031:analogs & derivatives / Q000138:chemical synthesis* / Q000302:isolation & purification*; D015394:Molecular Structure; D013237:Stereoisomerism; D031957:Ziziphus / Q000737:chemistry*
chemical_list: D002392:Catechin