title: Proliferative and nonproliferative lesions of the rat and mouse male reproductive system.
abstract: The INHAND Project (International Harmonization of Nomenclature and Diagnostic Criteria for Lesions in Rats and Mice) is a joint initiative of the Societies of Toxicologic Pathology from Europe (ESTP), Great Britain (BSTP), Japan (JSTP), and North America (STP) to develop an internationally accepted nomenclature for proliferative and nonproliferative lesions in laboratory animals. The purpose of this publication is to provide a standardized nomenclature and differential diagnosis for classifying microscopic lesions observed in the male reproductive system of laboratory rats and mice, with color microphotographs illustrating examples of some lesions. The standardized nomenclature presented in this document is also available for society members electronically on the Internet (http://goreni.org). Sources of material included histopathology databases from government, academia, and industrial laboratories throughout the world. Content includes spontaneous and aging lesions as well as lesions induced by exposure to test materials. A widely accepted and utilized international harmonization of nomenclature for lesions of the male reproductive system in laboratory animals will decrease confusion among regulatory and scientific research organizations in different countries and provide a common language to increase and enrich international exchanges of information among toxicologists and pathologists.
authors.affiliation: Huntingdon Life Sciences, East Millstone, New Jersey 08875, USA. creasyd@princeton.huntingdon.com
authors.forename: Dianne
authors.initials: D
authors.lastname: Creasy
authors.forename: Axel
authors.initials: A
authors.lastname: Bube
authors.forename: Eveline
authors.initials: E
authors.lastname: de Rijk
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Kandori
authors.forename: Maki
authors.initials: M
authors.lastname: Kuwahara
authors.forename: Regis
authors.initials: R
authors.lastname: Masson
authors.forename: Thomas
authors.initials: T
authors.lastname: Nolte
authors.forename: Rachel
authors.initials: R
authors.lastname: Reams
authors.forename: Karen
authors.initials: K
authors.lastname: Regan
authors.forename: Sabine
authors.initials: S
authors.lastname: Rehm
authors.forename: Petrina
authors.initials: P
authors.lastname: Rogerson
authors.forename: Katharine
authors.initials: K
authors.lastname: Whitney
mesh_terms: D000818:Animals; D000830:Animals, Laboratory; D035843:Biomedical Research / Q000592:standards*; D005832:Genital Diseases, Male / Q000145:classification / Q000473:pathology*; D005837:Genitalia, Male / Q000737:chemistry / Q000166:cytology / Q000473:pathology*; D006651:Histocytochemistry; D008297:Male; D051379:Mice; D051381:Rats; D009626:Terminology as Topic