title: Platelet function and thymosin β4.
abstract: Thymosin β4 (Tβ4) is a small, low-molecular-weight peptide ubiquitously expressed in all cells and extracellular fluids. It is a major actin sequestering protein present in the cells. In addition to this, Tβ4 has also been shown to be involved in endothelial cell migration, angiogenesis, corneal wound healing, and stem cell differentiation. It is also released by platelets after activation. The amount of Tβ4 increases at sites of injury and thus suggests an important role of this biopeptide in wound healing. Herein, we provide an overview of the role of Tβ4 in thrombosis and platelet aggregation.
authors.affiliation: Department of Chemistry and Biochemistry, University of Windsor, Windsor, Ontario, Canada.
authors.forename: Harmanpreet
authors.initials: H
authors.lastname: Kaur
authors.forename: Bulent
authors.initials: B
authors.lastname: Mutus
mesh_terms: D000818:Animals; D001792:Blood Platelets / Q000166:cytology / Q000502:physiology*; D006801:Humans; D010974:Platelet Aggregation; D021381:Protein Transport; D013927:Thrombosis; D013947:Thymosin / Q000737:chemistry* / Q000378:metabolism*; D000099201:Thymosin beta(4)
chemical_list: D013947:Thymosin; D000099201:Thymosin beta(4)