title: Biomimetic growth of hydroxyapatite on phosphorylated electrospun cellulose nanofibers.
abstract: In biomimicking the formation of collagen fiber/hydroxyapatite (HAp) in natural bone, electrospun cellulose nanofiber (CelluNF)/HAp composites were synthesized in simulated body fluid (SBF). Their morphology and structure were characterized by SEM, TEM, XRD and XPS. CelluNFs showed low bioactivity in inducing the growth of HAp. In order to improve this ability, CelluNFs were slightly phosphorylated with a degree of substitution of phosphate group of 0.28. The modified CelluNFs were highly effective in guiding the HAp growth along the fibers. The HAp crystal size in the composites was ca. 24 nm, and the lattice spacing of (211) plane was 2.83 Å. It was found that the HAps in the composites were calcium deficient. The CelluNF/HAp composites are highly porous materials with micro-, meso-, and macro-pores. A mechanism for the HAp growth on CelluNFs was presented. Such CelluNF/HAp composites can be potentially useful in the field of bone tissue engineering.
authors.affiliation: Key Laboratory of Polymer Materials of Fujian Province, College of Materials Science and Engineering, Fujian Normal University, Fujian 350007, China.
authors.forename: Kaina
authors.initials: K
authors.lastname: Li
authors.forename: Jiangnan
authors.initials: J
authors.lastname: Wang
authors.forename: Xinqing
authors.initials: X
authors.lastname: Liu
authors.forename: Xiaopeng
authors.initials: X
authors.lastname: Xiong
authors.forename: Haiqing
authors.initials: H
authors.lastname: Liu
mesh_terms: D032701:Biomimetics; D001842:Bone and Bones / Q000737:chemistry; D002482:Cellulose / Q000737:chemistry*; D017886:Durapatite / Q000737:chemistry*; D004563:Electrochemistry; D008855:Microscopy, Electron, Scanning; D046529:Microscopy, Electron, Transmission; D057139:Nanofibers / Q000737:chemistry* / Q000648:ultrastructure; D010766:Phosphorylation; D056951:Photoelectron Spectroscopy; D017550:Spectroscopy, Fourier Transform Infrared; D014961:X-Ray Diffraction
chemical_list: D002482:Cellulose; D017886:Durapatite