title: An improved algorithm for outbreak detection in multiple surveillance systems.
abstract: In England and Wales, a large-scale multiple statistical surveillance system for infectious disease outbreaks has been in operation for nearly two decades. This system uses a robust quasi-Poisson regression algorithm to identify abberrances in weekly counts of isolates reported to the Health Protection Agency. In this paper, we review the performance of the system with a view to reducing the number of false reports, while retaining good power to detect genuine outbreaks. We undertook extensive simulations to evaluate the existing system in a range of contrasting scenarios. We suggest several improvements relating to the treatment of trends, seasonality, re-weighting of baselines and error structure. We validate these results by running the existing and proposed new systems in parallel on real data. We find that the new system greatly reduces the number of alarms while maintaining good overall performance and in some instances increasing the sensitivity.
authors.affiliation: Department of Mathematics and Statistics, The Open University, Milton Keynes, UK. a.noufaily@open.ac.uk
authors.forename: Angela
authors.initials: A
authors.lastname: Noufaily
authors.forename: Doyo G
authors.initials: DG
authors.lastname: Enki
authors.forename: Paddy
authors.initials: P
authors.lastname: Farrington
authors.forename: Paul
authors.initials: P
authors.lastname: Garthwaite
authors.forename: Nick
authors.initials: N
authors.lastname: Andrews
authors.forename: André
authors.initials: A
authors.lastname: Charlett
mesh_terms: D000465:Algorithms; D056808:Biostatistics; D004196:Disease Outbreaks / Q000706:statistics & numerical data*; D004739:England; D005189:False Positive Reactions; D006801:Humans; D015233:Models, Statistical; D016012:Poisson Distribution; D011336:Probability; D062486:Public Health Surveillance / Q000379:methods*; D012044:Regression Analysis; D014852:Wales