title: Highly enantioselective conjugate addition of malononitrile to 2-enoylpyridines with bifunctional organocatalyst.
abstract: An efficient enantioselective conjugate addition of malononitrile to a range of β-substituted 2-enoylpyridines catalyzed by cinchona alkaloid-based bifunctional urea catalysts has been developed. Both enantiomers of the products could be achieved with the same level of enantioselectivity by using pseudoenantiomeric catalysts in up to 97% ee and in excellent yields. One of the enantioenriched products has been transformed to a highly functionalized piperidone derivative.
authors.affiliation: Department of Chemistry, Indian Institute of Science Education and Research Bhopal, ITI (Gas Rahat) Building, Govindpura, India 460 023.
authors.forename: Nagaraju
authors.initials: N
authors.lastname: Molleti
authors.forename: Nirmal K
authors.initials: NK
authors.lastname: Rana
authors.forename: Vinod K
authors.initials: VK
authors.lastname: Singh