title: The relationship between serum total testosterone and 24-hour urinary sodium excretion in never-treated stage 1 essential hypertensive patients.
abstract: OBJECTIVE
  To study the relationship between serum total testosterone (TT) and 24-hour urinary sodium excretion in newly diagnosed stage 1 essential hypertensive patients with normal renal function.
  
  
  METHODS
  In total, 80 never-treated stage 1 hypertensive patients were included. All patients provided medical history and underwent physical examination, blood pressure measurement, 12-lead electrocardiography, routine urine analysis, biochemical analysis, 24-hour urine collection to measure urinary sodium and protein excretion, and creatinine clearance calculation.
  
  
  RESULTS
  Pearson correlation analysis revealed that logarithmically converted 24-hour urinary sodium excretion was correlated with age (r=-0.399, p<0.0001), body mass index, (r=0.304, p=0.006), systolic blood pressure (r=0.394, p<0.0001), serum potassium (r=0.233, p=0.037), creatinine clearance (r=0.600, p<0.0001), and logarithmically converted serum TT (r=-0.272, p=0.015). Stepwise linear regression analysis revealed that age (p<0.0001), creatinine clearance (p=0.015), systolic blood pressure (p<0.0001), potassium (p=0.021), and serum TT (p=0.002) were independently related to logarithmically converted 24-hour sodium excretion.
  
  
  CONCLUSIONS
  We demonstrated that serum TT levels were independently related to 24-hour urinary sodium amount.
authors.affiliation: Department of Nephrology, Konya Numune State Hospital, Turkey. afsarbrs@yahoo.com
authors.forename: Barış
authors.initials: B
authors.lastname: Afşar
authors.forename: Mahmut
authors.initials: M
authors.lastname: Ay
authors.forename: Rukuye
authors.initials: R
authors.lastname: Burucu
authors.forename: Alper
authors.initials: A
authors.lastname: Kırkpantur
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D001794:Blood Pressure; D015992:Body Mass Index; D003404:Creatinine / Q000378:metabolism; D000075222:Essential Hypertension; D006801:Humans; D006973:Hypertension / Q000097:blood* / Q000503:physiopathology / Q000652:urine*; D016014:Linear Models; D008297:Male; D008875:Middle Aged; D011188:Potassium / Q000097:blood; D011507:Proteinuria / Q000652:urine; D012964:Sodium / Q000652:urine*; D013739:Testosterone / Q000097:blood*
chemical_list: D013739:Testosterone; D012964:Sodium; D003404:Creatinine; D011188:Potassium