title: The usefulness of the multiple allergen simultaneous test-chemiluminescent as compared to the Phadia Immunocap IgE test panel system in children and adolescents.
abstract: Several patents of methods for diagnostic work-up of IgE-mediated disease have recently been acclaimed. The aim of the present study was to assess the diagnostic usefulness of the Multiple allergen simultaneous test-chemiluminescent assay (MAST CLA) as compared to the Phadia Immunocap (Phadia CAP) allergen-specific IgE test panel system. The design was a prospective, observational study in which MAST CLA and Phadia CAP test panels were assessed in 105 children aged 1 to 17 years (46 girls and 59 boys) with a suspected diagnosis of rhinoconjunctivitis, asthma, eczema or food allergy. The MAST CLA screening panel included 23 and 13, the Phadia CAP 10 inhalant and 6 food allergens. The MAST CLA screening panel found 353 sensitizations which were not detected by Phadia CAP, 93 (26.3%) of which were class 3 or 4 results. The sensitizations gave clinically useful information in 7 patients (6.6%). As compared to the Phadia CAP the MAST CLA screening test panel adds little to the diagnostic work-up of IgE mediated disease in children and adolescents.
authors.affiliation: Asthma and Allergy Clinic, Children's Clinic Randers, Dytmaersken 9, DK-8900 Randers, Denmark. akk.odws@dadlnet.dk
authors.forename: Ole D
authors.initials: OD
authors.lastname: Wolthers
authors.forename: Morten
authors.initials: M
authors.lastname: Staberg
mesh_terms: D000293:Adolescent; D000485:Allergens / Q000032:analysis*; D002648:Child; D002675:Child, Preschool; D005240:Feasibility Studies; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D006969:Hypersensitivity, Immediate / Q000175:diagnosis*; D007073:Immunoglobulin E / Q000276:immunology*; D007223:Infant; D008163:Luminescent Measurements / Q000379:methods*; D008297:Male; D011446:Prospective Studies; D012680:Sensitivity and Specificity
chemical_list: D000485:Allergens; D007073:Immunoglobulin E