title: Atrial reverse remodeling: restitution of early tachycardia-induced alterations of atrial ion currents after termination of rapid atrial pacing in rabbits.
abstract: OBJECTIVE
  Studies report on the reversal of electrophysiological parameters altered by atrial tachycardia after cessation of the latter. However, there is no data concerning reversal of tachycardia-induced alterations of ion currents. Reverse remodeling of atrial ion currents (I(Ca,L), I(to), I(sus)) was studied in our rabbit model of tachycardia-induced electrical remodeling.
  
  
  METHODS
  Three groups each with four animals were built. Rapid atrial pacing (600/min) for 5 days was applied in all groups. Thereafter, different time intervals (5, 10, 20 days) were awaited before the patch clamp experiments.
  
  
  RESULTS
  Similar to I(to) remodeling in our model, within 20 days after cessation of atrial tachycardia, time course of I(to) reverse remodeling was also U-shaped. In contrast, there was no significant recovery of I(Ca,L) which was initially reduced by rapid atrial pacing.
  
  
  CONCLUSIONS
  Relevance of a missing recovery of I(Ca,L) is likely as this current is closely linked with intracellular calcium handling.
authors.affiliation: Department of Cardiology, University of Tuebingen, Otfried-Mueller-Strasse 10, D-72076 Tuebingen, Germany. roman.laszlo@gmx.de
authors.forename: Roman
authors.initials: R
authors.lastname: Laszlo
authors.forename: Agnes
authors.initials: A
authors.lastname: Konior
authors.forename: Kerstin
authors.initials: K
authors.lastname: Bentz
authors.forename: Christian
authors.initials: C
authors.lastname: Eick
authors.forename: Birgit
authors.initials: B
authors.lastname: Schreiner
authors.forename: Juergen
authors.initials: J
authors.lastname: Schreieck
authors.forename: Ralph F
authors.initials: RF
authors.lastname: Bosch
mesh_terms: D000818:Animals; D002304:Cardiac Pacing, Artificial / Q000379:methods / Q000662:veterinary*; D006325:Heart Atria / Q000378:metabolism*; D007473:Ion Channels / Q000502:physiology*; D011817:Rabbits / Q000502:physiology*; D013610:Tachycardia / Q000209:etiology / Q000378:metabolism / Q000662:veterinary*
chemical_list: D007473:Ion Channels