title: One-pot synthesis of chitosan-g-(PEO-PLLA-PEO) via "click" chemistry and "SET-NRC" reaction.
abstract: For the development of biocompatible and degradable biomaterials, a kind of well-defined graft copolymer consisting of chitosan back-bone and amphiphilic PEO-PLLA-PEO branch chains was synthesized by Cu(0) catalyzed one-pot strategy combining "click" chemistry and single electron transfer-nitroxide radical coupling (SET-NRC) reaction. First, the precursors of 6-azide-N-phthaloyl-chitosan, TEMPO-PEO-alkyne and mPEO-PLLA-Br were designed and produced. Then, the one-pot coupling reactions between these precursors were performed in the presence of nanosized Cu and PMDETA. The efficiencies of the coupling reactions were greater than 90% determined by the FTIR and ESR spectra. The structure of graft copolymer with 43% of the grafting ratio was confirmed by the spectral analysis. This work provided a route to prepare chitosan graft copolymer.
authors.affiliation: MOE Key Laboratory of Macromolecular Synthesis and Functionalization, Department of Polymer Science and Engineering, Zhejiang University, Hangzhou 310027, China.
authors.forename: Ke
authors.initials: K
authors.lastname: Zhang
authors.forename: Pengyu
authors.initials: P
authors.lastname: Zhuang
authors.forename: Zhengke
authors.initials: Z
authors.lastname: Wang
authors.forename: Youliang
authors.initials: Y
authors.lastname: Li
authors.forename: Zhiqiang
authors.initials: Z
authors.lastname: Jiang
authors.forename: Qiaoling
authors.initials: Q
authors.lastname: Hu
authors.forename: Minying
authors.initials: M
authors.lastname: Liu
authors.forename: Qingxiang
authors.initials: Q
authors.lastname: Zhao
mesh_terms: D001672:Biocompatible Materials / Q000737:chemistry*; D048271:Chitosan / Q000737:chemistry*; D057930:Click Chemistry; D019344:Lactic Acid / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D009019:Morphinans / Q000737:chemistry*; D011091:Polyesters; D011108:Polymers / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D001672:Biocompatible Materials; D009019:Morphinans; D011091:Polyesters; D011108:Polymers; C544195:phenylethyl orvinol; D019344:Lactic Acid; C033616:poly(lactide); D048271:Chitosan