title: Determinants of uterine aging: lessons from rodent models.
abstract: The uterus is an indispensable organ for the development of a new life in eutherian mammals. The female mammalian reproductive capacity diminishes with age. In this respect, the senescence of uterine endometrium is convinced to contribute to this failure. This review focuses on the physiological function of the uterus and the related influence of aging mainly in rodent models. A better understanding of the underlying mechanisms governing the process of uterine aging is hoped to generate new strategies to prolong the reproductive lifespan in humans.
authors.affiliation: State Key Laboratory of Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, 100101, China.
authors.forename: ShuangBo
authors.initials: S
authors.lastname: Kong
authors.forename: Shuang
authors.initials: S
authors.lastname: Zhang
authors.forename: YongJie
authors.initials: Y
authors.lastname: Chen
authors.forename: WeiXiang
authors.initials: W
authors.lastname: Wang
authors.forename: BingYan
authors.initials: B
authors.lastname: Wang
authors.forename: Qi
authors.initials: Q
authors.lastname: Chen
authors.forename: EnKui
authors.initials: E
authors.lastname: Duan
authors.forename: HaiBin
authors.initials: H
authors.lastname: Wang
mesh_terms: D000375:Aging / Q000473:pathology / Q000502:physiology*; D000818:Animals; D004717:Endometrium / Q000473:pathology / Q000502:physiology; D005260:Female; D012739:Gonadal Steroid Hormones / Q000502:physiology; D006801:Humans; D051379:Mice; D023421:Models, Animal; D011247:Pregnancy; D012098:Reproduction / Q000502:physiology; D012377:Rodentia; D014599:Uterus / Q000473:pathology / Q000502:physiology*
chemical_list: D012739:Gonadal Steroid Hormones