title: Quantitative assessment of the effects of MMP-2 polymorphisms on lung carcinoma risk.
abstract: BACKGROUND
  Previous studies assessing associations between matrix metalloproteinase 2 (MMP-2) polymorphisms and lung cancer risk reported conflicting results. A meta-analysis was therefore performed to derive a more precise estimation.
  
  
  METHODS
  Case-control studies assessing associations between MMP-2 C735T and C1306T polymorphisms and lung cancer risk were included. Pooled odds ratios (ORs) with 95% confidence intervals (CIs) were estimated.
  
  
  RESULTS
  7 studies with a total of 3,189 lung cancer cases and 3,013 controls were finally included into this meta-analysis. Overall, the MMP-2 C735T polymorphism was associated with lung cancer risk under the homozygote model (CC versus TT: OR =1.44, 95% CI = 1.03-2.02, I2 = 0%), while the MMP- 2 C1306T polymorphism also associated demonstrated links with all four models (all P values less than 0.05). Subgroup analyses by race suggested obvious associations between MMP-2 C735T and C1306T polymorphisms and lung cancer risk in Asians but not in Caucasians. There was no evidence for publication bias.
  
  
  CONCLUSIONS
  Currently available evidence supports teh conclusion that MMP-2 C735T and C1306T polymorphisms influence susceptibility to lung cancer in Asians.
authors.affiliation: Department of Thoracic Surgery, the 2nd Affiliated Hospital of Harbin Medical University, Harbin, China.
authors.forename: Xiao-Tong
authors.initials: XT
authors.lastname: Guo
authors.forename: Jun-Feng
authors.initials: JF
authors.lastname: Wang
authors.forename: Lin-You
authors.initials: LY
authors.lastname: Zhang
authors.forename: Guang-Quan
authors.initials: GQ
authors.lastname: Xu
mesh_terms: D016022:Case-Control Studies; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008175:Lung Neoplasms / Q000235:genetics*; D020778:Matrix Metalloproteinase 2 / Q000235:genetics*; D016017:Odds Ratio; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors
chemical_list: D020778:Matrix Metalloproteinase 2