title: Schizonepeta tenuifolia inhibits the development of atopic dermatitis in mice.
abstract: Historically, Schizonepeta tenuifolia (ST) has been used for the treatment of skin disorders, such as allergic dermatitis, eczema, and inflammatory diseases. In this study, we examined whether ST inhibited 2,4-dinitrochlorobenzene (DNCB)-induced atopic dermatitis (AD) in BALB/c mice. In histopathological analyses of the epidermis and dermis, skin thickness was significantly increased in DNCB-induced mice as compared with normal group. Treatment with ST inhibited this inflammatory change and markedly suppressed the secretion of immunoglobulin E, tumor necrosis factor α, and interleukin 6 levels in the serum of DNCB-induced mice. In addition, ST treatment significantly restored the upregulation of proinflammatory factors, such as nuclear factor (NF)-κB and mitogen-activated protein kinase expression. Taken together, due to its ability to suppress inflammatory factors and upregulate proinflammatory factors, ST may be useful as a therapeutic treatment for AD. ST extract application decreased both epidermis and dermis thickness in DNCB-induced mice. In serum, ST reduced immunoglobulin E, tumor necrosis factor, and interleukin 6 level. In addition, ST suppressed NF-κB activation as well as the mitogen-activated protein kinase activities.
authors.affiliation: Department of Prescriptionology, College of Oriental Medicine, Institute of Oriental Medicine, Kyung Hee University, Seoul, Korea.
authors.forename: You Yeon
authors.initials: YY
authors.lastname: Choi
authors.forename: Mi Hye
authors.initials: MH
authors.lastname: Kim
authors.forename: Jong-Hyun
authors.initials: JH
authors.lastname: Kim
authors.forename: Hyuk-Sang
authors.initials: HS
authors.lastname: Jung
authors.forename: Youngjoo
authors.initials: Y
authors.lastname: Sohn
authors.forename: Young Jin
authors.initials: YJ
authors.lastname: Choi
authors.forename: Man Ki
authors.initials: MK
authors.lastname: Hwang
authors.forename: Sung-Hoon
authors.initials: SH
authors.lastname: Kim
authors.forename: Jinju
authors.initials: J
authors.lastname: Kim
authors.forename: Woong Mo
authors.initials: WM
authors.lastname: Yang
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology*; D003876:Dermatitis, Atopic / Q000139:chemically induced / Q000188:drug therapy*; D004137:Dinitrochlorobenzene; D004195:Disease Models, Animal; D005260:Female; D007073:Immunoglobulin E / Q000097:blood; D015850:Interleukin-6 / Q000097:blood; D019686:Lamiaceae / Q000737:chemistry*; D051379:Mice; D008807:Mice, Inbred BALB C; D020928:Mitogen-Activated Protein Kinases / Q000378:metabolism; D016328:NF-kappa B / Q000378:metabolism; D010936:Plant Extracts / Q000494:pharmacology*; D012867:Skin / Q000187:drug effects; D014409:Tumor Necrosis Factor-alpha / Q000097:blood
chemical_list: D000893:Anti-Inflammatory Agents; D004137:Dinitrochlorobenzene; D015850:Interleukin-6; D016328:NF-kappa B; D010936:Plant Extracts; D014409:Tumor Necrosis Factor-alpha; D007073:Immunoglobulin E; D020928:Mitogen-Activated Protein Kinases