title: Seizure developed after palonosetron intravenous injection during recovery from general anesthesia -A case report-.
abstract: Seizure associated with antiemetics is rare. We report seizure associated with a 5-HT(3) receptor antagonist in a 38 years old female. The patient underwent ureterorenoscopic lithotripsy due to left upper ureter stone. After operation, the patient complained of nausea in the postanesthetic recovery unit. In order to subside symptom, the patient was administrated 5-HT(3) receptor antagonist, palonosetron, 0.075 mg intravenously. Shortly after administration of that, the patient developed generalized tonic-clonic seizures. The symptom was subsided after midazolam and thiopental sodium were injected. But 40 minutes later, seizure recurred and subsided with midazolam again. The patient recovered completely without any specific sequelae.
authors.affiliation: Department of Anesthesiology and Pain Medicine, Chung-Ang University Hospital, Seoul, Korea.
authors.forename: Pyung-Gul
authors.initials: PG
authors.lastname: Park
authors.forename: Hwa-Yong
authors.initials: HY
authors.lastname: Shin
authors.forename: Hyun
authors.initials: H
authors.lastname: Kang
authors.forename: Yong Hun
authors.initials: YH
authors.lastname: Jung
authors.forename: Young-Cheol
authors.initials: YC
authors.lastname: Woo
authors.forename: Jin-Yun
authors.initials: JY
authors.lastname: Kim
authors.forename: Gill Hoi
authors.initials: GH
authors.lastname: Koo
authors.forename: Sun Gyoo
authors.initials: SG
authors.lastname: Park
authors.forename: Chong Wha
authors.initials: CW
authors.lastname: Baek