title: Cell biology. The unusual case of Porcupine.
authors.affiliation: Department of Cell Biology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA. lawrence.lum@utsouthwestern.edu
authors.forename: Lawrence
authors.initials: L
authors.lastname: Lum
authors.forename: Hans
authors.initials: H
authors.lastname: Clevers
mesh_terms: D000091162:AMP-Activated Protein Kinase Kinases; D000217:Acyltransferases; D000970:Antineoplastic Agents / Q000494:pharmacology / Q000627:therapeutic use*; D017321:Clinical Trials, Phase I as Topic; D004268:DNA-Binding Proteins / Q000235:genetics; D055808:Drug Discovery; D004791:Enzyme Inhibitors / Q000494:pharmacology / Q000627:therapeutic use*; D006801:Humans; D008565:Membrane Proteins / Q000037:antagonists & inhibitors* / Q000235:genetics / Q000378:metabolism*; D058990:Molecular Targeted Therapy; D009154:Mutation; D009369:Neoplasms / Q000188:drug therapy* / Q000235:genetics / Q000378:metabolism; D015513:Oncogene Proteins / Q000235:genetics; D019308:Palmitic Acid / Q000378:metabolism; D017346:Protein Serine-Threonine Kinases / Q000235:genetics; D044767:Ubiquitin-Protein Ligases; D051153:Wnt Proteins / Q000378:metabolism*; D060449:Wnt Signaling Pathway / Q000187:drug effects*
chemical_list: D000970:Antineoplastic Agents; D004268:DNA-Binding Proteins; D004791:Enzyme Inhibitors; D008565:Membrane Proteins; D015513:Oncogene Proteins; D051153:Wnt Proteins; D019308:Palmitic Acid; D000217:Acyltransferases; C491188:PORCN protein, human; C496945:RNF43 protein, human; D044767:Ubiquitin-Protein Ligases; D017346:Protein Serine-Threonine Kinases; C109790:STK11 protein, human; D000091162:AMP-Activated Protein Kinase Kinases