title: Unusual basal ganglia lesions in a diabetic uraemic patient proven to be demyelination: first pathological observation.
abstract: A 64-year-old man suffering from diabetes mellitus and chronic renal failure was admitted to our hospital because of consciousness disturbance and parkinsonism. Cranial MRI showed very characteristic features involving the bilateral basal ganglia. Subsequent postmortem examinations demonstrated demyelination in the affected areas. These myelin destruction patterns were quite similar to those of central pontine myelinolysis. However, rapid correction of hyponatraemia was ruled out in this patient. Therefore, a new demyelinating brain disease associated with diabetes mellitus and chronic renal failure was suggested.
authors.affiliation: Department of Neurology, Brain Health Center, Sapporo City General Hospital, Sapporo, Japan. yasutaka.tajima@doc.city.sapporo.jp
authors.forename: Yasutaka
authors.initials: Y
authors.lastname: Tajima
authors.forename: Yasunori
authors.initials: Y
authors.lastname: Mito
authors.forename: Mituru
authors.initials: M
authors.lastname: Yanai
authors.forename: Yu-Ichiro
authors.initials: Y
authors.lastname: Fukazawa
mesh_terms: D001224:Aspartic Acid / Q000031:analogs & derivatives / Q000378:metabolism; D001479:Basal Ganglia / Q000473:pathology; D001480:Basal Ganglia Diseases / Q000473:pathology*; D003711:Demyelinating Diseases / Q000473:pathology*; D003928:Diabetic Nephropathies / Q000473:pathology*; D003937:Diagnosis, Differential; D038524:Diffusion Magnetic Resonance Imaging; D005500:Follow-Up Studies; D006801:Humans; D007564:Japan; D008264:Macrophages / Q000473:pathology; D008279:Magnetic Resonance Imaging; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D008875:Middle Aged; D017590:Myelinolysis, Central Pontine / Q000473:pathology; D009460:Neurologic Examination; D010300:Parkinson Disease / Q000473:pathology; D011699:Putamen / Q000473:pathology; D012772:Shock, Septic / Q000473:pathology; D014511:Uremia / Q000473:pathology*
chemical_list: D001224:Aspartic Acid; C000179:N-acetylaspartate