title: Enantioselective construction of pyrroloindolines via chiral phosphoric acid catalyzed cascade Michael addition-cyclization of tryptamines.
abstract: Enantioselective construction of pyrroloindolines via chiral phosphoric acid catalyzed cascade Michael addition-cyclization of tryptamines has been realized. With 5 mol % of chiral phosphoric acid, enantioenriched pyrroloindoline derivatives were obtained in good yields and enantioselectivity (up to 95% yield and 83% ee) from readily available tryptamines and enones.
authors.affiliation: State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Lu, Shanghai 200032, China.
authors.forename: Quan
authors.initials: Q
authors.lastname: Cai
authors.forename: Chuan
authors.initials: C
authors.lastname: Liu
authors.forename: Xiao-Wei
authors.initials: XW
authors.lastname: Liang
authors.forename: Shu-Li
authors.initials: SL
authors.lastname: You
mesh_terms: D002384:Catalysis; D020650:Combinatorial Chemistry Techniques; D003500:Cyclization; D006575:Heterocyclic Compounds, 3-Ring / Q000138:chemical synthesis* / Q000737:chemistry; D007211:Indoles / Q000138:chemical synthesis* / Q000737:chemistry*; D015394:Molecular Structure; D010756:Phosphoric Acids / Q000737:chemistry*; D011758:Pyrroles / Q000138:chemical synthesis* / Q000737:chemistry; D013237:Stereoisomerism; D014363:Tryptamines / Q000737:chemistry*
chemical_list: D006575:Heterocyclic Compounds, 3-Ring; D007211:Indoles; D010756:Phosphoric Acids; D011758:Pyrroles; D014363:Tryptamines; C030242:phosphoric acid