title: Tadalafil and acetazolamide versus acetazolamide for the prevention of severe high-altitude illness.
abstract: We report an open-label study comparing tadalafil and acetazolamide (n = 24) versus acetazolamide (n = 27) for prevention of high-altitude illness (HAI) at Mt. Kilimanjaro. Tadalafil group had lower rates of severe HAI compared with controls (4% vs 26%, p = 0.03), mostly because of decreased high-altitude pulmonary edema rates (4% vs 22%, p = 0.06).
authors.affiliation: Center for Geographic Medicine and Internal Medicine C, Sheba Medical Center, Tel-Hashomer and Sackler Faculty of Medicine, Tel Aviv, Israel.
authors.forename: Eyal
authors.initials: E
authors.lastname: Leshem
authors.forename: Yehezkel
authors.initials: Y
authors.lastname: Caine
authors.forename: Elliot
authors.initials: E
authors.lastname: Rosenberg
authors.forename: Yoram
authors.initials: Y
authors.lastname: Maaravi
authors.forename: Hagai
authors.initials: H
authors.lastname: Hermesh
authors.forename: Eli
authors.initials: E
authors.lastname: Schwartz
mesh_terms: D000086:Acetazolamide / Q000008:administration & dosage*; D000208:Acute Disease; D000328:Adult; D000532:Altitude Sickness / Q000188:drug therapy / Q000517:prevention & control*; D002243:Carbolines / Q000008:administration & dosage*; D002257:Carbonic Anhydrase Inhibitors / Q000008:administration & dosage*; D004305:Dose-Response Relationship, Drug; D006261:Headache / Q000517:prevention & control; D006801:Humans; D006976:Hypertension, Pulmonary / Q000188:drug therapy / Q000517:prevention & control*; D008297:Male; D009051:Mountaineering; D012720:Severity of Illness Index; D000068581:Tadalafil; D013636:Tanzania; D055815:Young Adult
chemical_list: D002243:Carbolines; D002257:Carbonic Anhydrase Inhibitors; D000068581:Tadalafil; D000086:Acetazolamide