title: [The costs of urinary tract infection therapy with implementation of pharmacoeconomic guidelines at the Clinic for Infectious Diseases of the Clinical Center of Vojvodina].
abstract: OBJECTIVE
  The Serbian health system does not have strict guidelines for the treatment of bacterial infections. The choice of treatment is empirical which is not necessarily the same compared to the treatment guidelines from countries with a developed pharmacotherapeutic practice. In this study we compared the difference between the current treatment and the treatment taking into account the latest pharmacotherapeutic and pharmacoeconomic guidelines in order to estimate clinical efficiency of antibacterial drugs that were given as a therapy of urinary tract infections and to evaluate pharmacoeconomic aspect of this therapy as well.
  
  
  METHODS
  Our study included 100 patients that were randomly chosen and divided into 2 groups. The first group was treated in an ordinary way, while the second one was treated strictly in accordance with the guidelines (British National Formulary - BNF, and Senford Guide). In both groups of the patients we compared length of hospitalization, combination of the used antibiotics, progress as a whole in clinical picture, laboratory analyses and the price of the whole treatment.
  
  
  RESULTS
  Analyzing these values independently and according to statistical tests we proved that there were no significant differences between two groups with regard to the progress in a clinical picture as a whole and the length of hospitalization. According to this analysis, however suggested treatment based on guidelines showed a saving of 34.48% in comparison with the usual system of therapy.
  
  
  CONCLUSIONS
  Efficacy of current treatment of urinary tract infection and the treatment according to foreign guidelines is the same, but the costs of the treatment are lower if the guidelines of developed health care systems are applied.
authors.affiliation: Klinika za infektivne bolesti, Klinicki centar Vojvodine, Novi Sad, Srbija. mikic@nscable.net
authors.forename: Sandra
authors.initials: S
authors.lastname: Stefan-Mikić
authors.forename: Sinisa
authors.initials: S
authors.lastname: Sević
authors.forename: Radoslava
authors.initials: R
authors.lastname: Doder
authors.forename: Dejan
authors.initials: D
authors.lastname: Cvjetković
authors.forename: Natasa
authors.initials: N
authors.lastname: Jovanović
authors.forename: Maja
authors.initials: M
authors.lastname: Ruzić
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000900:Anti-Bacterial Agents / Q000191:economics* / Q000627:therapeutic use; D002648:Child; D002675:Child, Preschool; D003365:Costs and Cost Analysis; D005260:Female; D019983:Guideline Adherence; D006801:Humans; D007902:Length of Stay; D008297:Male; D008875:Middle Aged; D055771:Serbia; D014552:Urinary Tract Infections / Q000188:drug therapy / Q000191:economics*; D055815:Young Adult
chemical_list: D000900:Anti-Bacterial Agents