title: The contribution of transgenic plants to better health through improved nutrition: opportunities and constraints.
abstract: Malnutrition is a prevalent and entrenched global socioeconomic challenge that reflects the combined impact of poverty, poor access to food, inefficient food distribution infrastructure, and an over-reliance on subsistence mono-agriculture. The dependence on staple cereals lacking many essential nutrients means that malnutrition is endemic in developing countries. Most individuals lack diverse diets and are therefore exposed to nutrient deficiencies. Plant biotechnology could play a major role in combating malnutrition through the engineering of nutritionally enhanced crops. In this article, we discuss different approaches that can enhance the nutritional content of staple crops by genetic engineering (GE) as well as the functionality and safety assessments required before nutritionally enhanced GE crops can be deployed in the field. We also consider major constraints that hinder the adoption of GE technology at different levels and suggest policies that could be adopted to accelerate the deployment of nutritionally enhanced GE crops within a multicomponent strategy to combat malnutrition.
authors.affiliation: Department of Plant Production and Forestry Science, ETSEA, University of Lleida-Agrotecnio Center, Av. Alcalde Rovira Roure, 191, 25198, Lleida, Spain.
authors.forename: Eduard
authors.initials: E
authors.lastname: Pérez-Massot
authors.forename: Raviraj
authors.initials: R
authors.lastname: Banakar
authors.forename: Sonia
authors.initials: S
authors.lastname: Gómez-Galera
authors.forename: Uxue
authors.initials: U
authors.lastname: Zorrilla-López
authors.forename: Georgina
authors.initials: G
authors.lastname: Sanahuja
authors.forename: Gemma
authors.initials: G
authors.lastname: Arjó
authors.forename: Bruna
authors.initials: B
authors.lastname: Miralpeix
authors.forename: Evangelia
authors.initials: E
authors.lastname: Vamvaka
authors.forename: Gemma
authors.initials: G
authors.lastname: Farré
authors.forename: Sol Maiam
authors.initials: SM
authors.lastname: Rivera
authors.forename: Svetlana
authors.initials: S
authors.lastname: Dashevskaya
authors.forename: Judit
authors.initials: J
authors.lastname: Berman
authors.forename: Maite
authors.initials: M
authors.lastname: Sabalza
authors.forename: Dawei
authors.initials: D
authors.lastname: Yuan
authors.forename: Chao
authors.initials: C
authors.lastname: Bai
authors.forename: Ludovic
authors.initials: L
authors.lastname: Bassie
authors.forename: Richard M
authors.initials: RM
authors.lastname: Twyman
authors.forename: Teresa
authors.initials: T
authors.lastname: Capell
authors.forename: Paul
authors.initials: P
authors.lastname: Christou
authors.forename: Changfu
authors.initials: C
authors.lastname: Zhu