title: [Hereditary leiomyomatosis and renal cell cancer - HLRCC/multiple cutaneous and uterine leimomyomatosis - MCUL].
abstract: Hereditary leiomyomatosis and renal cell cancer / multiple cutaneous and uterine leimomyomatosis is a relatively rare autosomal dominant condition which predisposes to the development of cutaneous and uterine leiomyomas and early-onset renal cell carcinoma, typically papillary carcinoma type II. It is caused by germline mutations in the FH gene encoding the fumarate hydratase enzyme. The test of fumarate hydratase activity in lymphocytes may be used as a screening method with subsequent mutation analysis of the FH gene in persons with reduced enzyme activity. Persons with this syndrome should be followed to detect any occurrence of these diseases. Treatment of renal cancer associated with the hereditary leiomyomatosis and renal cell cancer syndrome should be radical with respect to its aggressive nature.
authors.affiliation: Oddělení lékařské genetiky, Fakultní nemocnice Ostrava. pavlina.plevova@volny.cz
authors.forename: P
authors.initials: P
authors.lastname: Plevová
authors.forename: A
authors.initials: A
authors.lastname: Hladíková
authors.forename: M
authors.initials: M
authors.lastname: Tesařová
mesh_terms: D003937:Diagnosis, Differential; D005260:Female; D005649:Fumarate Hydratase / Q000235:genetics; D018095:Germ-Line Mutation; D006801:Humans; D007680:Kidney Neoplasms / Q000175:diagnosis / Q000235:genetics*; D018231:Leiomyomatosis / Q000175:diagnosis / Q000235:genetics*; D009378:Neoplasms, Multiple Primary / Q000235:genetics; D009386:Neoplastic Syndromes, Hereditary / Q000175:diagnosis / Q000235:genetics*; D012878:Skin Neoplasms / Q000235:genetics*; D014594:Uterine Neoplasms / Q000235:genetics*
chemical_list: D005649:Fumarate Hydratase