title: Contribution of common genetic variation to the risk of type 2 diabetes in the Mexican Mestizo population.
abstract: Several studies have identified nearly 40 different type 2 diabetes susceptibility loci, mainly in European populations, but few of them have been evaluated in the Mexican population. The aim of this study was to examine the extent to which 24 common genetic variants previously associated with type 2 diabetes are associated in Mexican Mestizos. Twenty-four single nucleotide polymorphisms (SNPs) in or near genes (KCNJ11, PPARG, TCF7L2, SLC30A8, HHEX, CDKN2A/2B, CDKAL1, IGF2BP2, ARHGEF11, JAZF1, CDC123/CAMK1D, FTO, TSPAN8/LGR5, KCNQ1, THADA, ADAMTS9, NOTCH2, NXPH1, RORA, UBQLNL, and RALGPS2) were genotyped in Mexican Mestizos. A case-control association study comprising 1,027 type 2 diabetic individuals and 990 control individuals was conducted. To account for population stratification, a panel of 104 ancestry-informative markers was analyzed. Association to type 2 diabetes was found for rs13266634 (SLC30A8), rs7923837 (HHEX), rs10811661 (CDKN2A/2B), rs4402960 (IGF2BP2), rs12779790 (CDC123/CAMK1D), and rs2237892 (KCNQ1). In addition, rs7754840 (CDKAL1) was associated in the nonobese type 2 diabetic subgroup, and for rs7903146 (TCF7L2), association was observed for early-onset type 2 diabetes. Lack of association for the rest of the variants may have resulted from insufficient power to detect smaller allele effects.
authors.affiliation: Unidad de Biología Molecular y Medicina Genómica, Instituto de Investigaciones Biomédicas de la Universidad Nacional Autónoma de México e Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico.
authors.forename: Marco Alberto
authors.initials: MA
authors.lastname: Gamboa-Meléndez
authors.forename: Alicia
authors.initials: A
authors.lastname: Huerta-Chagoya
authors.forename: Hortensia
authors.initials: H
authors.lastname: Moreno-Macías
authors.forename: Paola
authors.initials: P
authors.lastname: Vázquez-Cárdenas
authors.forename: María Luisa
authors.initials: ML
authors.lastname: Ordóñez-Sánchez
authors.forename: Rosario
authors.initials: R
authors.lastname: Rodríguez-Guillén
authors.forename: Laura
authors.initials: L
authors.lastname: Riba
authors.forename: Maribel
authors.initials: M
authors.lastname: Rodríguez-Torres
authors.forename: María Teresa
authors.initials: MT
authors.lastname: Guerra-García
authors.forename: Luz Elizabeth
authors.initials: LE
authors.lastname: Guillén-Pineda
authors.forename: Shweta
authors.initials: S
authors.lastname: Choudhry
authors.forename: Laura
authors.initials: L
authors.lastname: Del Bosque-Plata
authors.forename: Samuel
authors.initials: S
authors.lastname: Canizales-Quinteros
authors.forename: Gustavo
authors.initials: G
authors.lastname: Pérez-Ortiz
authors.forename: Fernando
authors.initials: F
authors.lastname: Escobedo-Aguirre
authors.forename: Adalberto
authors.initials: A
authors.lastname: Parra
authors.forename: Israel
authors.initials: I
authors.lastname: Lerman-Garber
authors.forename: Carlos Alberto
authors.initials: CA
authors.lastname: Aguilar-Salinas
authors.forename: María Teresa
authors.initials: MT
authors.lastname: Tusié-Luna
mesh_terms: D054729:Calcium-Calmodulin-Dependent Protein Kinase Type 1 / Q000235:genetics; D027682:Cation Transport Proteins / Q000235:genetics; D051360:Cyclin-Dependent Kinase 5 / Q000235:genetics; D050762:Cyclin-Dependent Kinase Inhibitor p15 / Q000235:genetics; D003924:Diabetes Mellitus, Type 2 / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease / Q000235:genetics; D055106:Genome-Wide Association Study; D005838:Genotype; D018398:Homeodomain Proteins / Q000235:genetics; D006801:Humans; D051657:KCNQ1 Potassium Channel / Q000235:genetics; D008297:Male; D008800:Mexico; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D016601:RNA-Binding Proteins / Q000235:genetics; D058118:Transcription Factor 7-Like 2 Protein / Q000235:genetics; D014157:Transcription Factors / Q000235:genetics; D000075703:Zinc Transporter 8; D012359:tRNA Methyltransferases
chemical_list: C493966:CDKN2B protein, human; D027682:Cation Transport Proteins; D050762:Cyclin-Dependent Kinase Inhibitor p15; C078492:HHEX protein, human; D018398:Homeodomain Proteins; C498779:IGF2BP2 protein, human; D051657:KCNQ1 Potassium Channel; C496909:KCNQ1 protein, human; D016601:RNA-Binding Proteins; C492522:SLC30A8 protein, human; D058118:Transcription Factor 7-Like 2 Protein; D014157:Transcription Factors; D000075703:Zinc Transporter 8; D012359:tRNA Methyltransferases; D051360:Cyclin-Dependent Kinase 5; C517601:CAMK1D protein, human; D054729:Calcium-Calmodulin-Dependent Protein Kinase Type 1; C525110:CDKAL1 protein, human