title: The results of total humeral replacement following excision for primary bone tumour.
abstract: Rarely, the extent of a malignant bone tumour   may necessitate resection of the complete humerus to achieve adequate   oncological clearance. We present our experience with reconstruction   in such cases using a total humeral endoprosthesis (THER) in 20   patients (12 male and eight female) with a mean age of 22 years   (6 to 59). We assessed the complications, the oncological and functional   outcomes and implant survival. Surgery was performed between June   2001 and October 2009. The diagnosis included osteosarcoma in nine,   Ewing's sarcoma in eight and chondrosarcoma in three. One patient   was lost to follow-up. The mean follow-up was 41 months (10 to 120)   for all patients and 56 months (25 to 120) in survivors. There were   five local recurrences (26.3%) and 11 patients were alive at time   of last follow-up, with overall survival for all patients being   52% (95% confidence interval (CI) 23.8 to 74) at five years. The   mean Musculoskeletal Tumor Society score for the survivors was 22   (73%; 16 to 23). The implant survival was 95% (95% CI 69.5 to 99.3)   at five years. The use of a THER in the treatment of malignant tumours of bone   is oncologically safe; it gives consistent and predictable results   with low rates of complication.
authors.affiliation: Tata Memorial Hospital, E Borges Road, Parel, Mumbai 400012, India. docpuri@gmail.com
authors.forename: A
authors.initials: A
authors.lastname: Puri
authors.forename: A
authors.initials: A
authors.lastname: Gulia
mesh_terms: D000293:Adolescent; D000328:Adult; D001859:Bone Neoplasms / Q000401:mortality / Q000601:surgery*; D016025:Bone Transplantation / Q000379:methods; D002648:Child; D002813:Chondrosarcoma / Q000401:mortality / Q000601:surgery*; D018572:Disease-Free Survival; D019544:Equipment Failure Analysis; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D006811:Humerus / Q000601:surgery*; D015994:Incidence; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000453:epidemiology; D012516:Osteosarcoma / Q000401:mortality / Q000601:surgery*; D019736:Prostheses and Implants; D011474:Prosthesis Design; D016059:Range of Motion, Articular; D019651:Plastic Surgery Procedures / Q000379:methods; D020127:Recovery of Function; D012512:Sarcoma, Ewing / Q000401:mortality / Q000601:surgery*; D012785:Shoulder Joint / Q000503:physiopathology; D015996:Survival Rate; D055815:Young Adult