title: Structure-activity relationships of a novel group of large-conductance Ca(2+)-activated K(+) (BK) channel modulators: the GoSlo-SR family.
abstract: Opening up ion channels: We synthesised a series of anthraquinone analogues, called the GoSlo-SR family. Their effects on bladder smooth muscle BK channels were examined and, as shown, shifted voltage dependent activation >-100 mV (at 10 μM). They were more efficacious than NS11021 and could provide a new scaffold for the design of efficacious BK openers.
authors.affiliation: Ion Channel Biotechnology Centre, Dundalk Institute of Technology, Dublin Road, Dundalk, Co. Louth, Ireland.
authors.forename: Subhrangsu
authors.initials: S
authors.lastname: Roy
authors.forename: Adebola
authors.initials: A
authors.lastname: Morayo Akande
authors.forename: Roddy J
authors.initials: RJ
authors.lastname: Large
authors.forename: Tim I
authors.initials: TI
authors.lastname: Webb
authors.forename: Costin
authors.initials: C
authors.lastname: Camarasu
authors.forename: Gerard P
authors.initials: GP
authors.lastname: Sergeant
authors.forename: Noel G
authors.initials: NG
authors.lastname: McHale
authors.forename: Keith D
authors.initials: KD
authors.lastname: Thornbury
authors.forename: Mark A
authors.initials: MA
authors.lastname: Hollywood
mesh_terms: D000818:Animals; D000880:Anthraquinones / Q000737:chemistry; D051036:Large-Conductance Calcium-Activated Potassium Channels / Q000737:chemistry* / Q000378:metabolism; D009130:Muscle, Smooth / Q000502:physiology; D018408:Patch-Clamp Techniques; D026902:Potassium Channel Blockers / Q000737:chemistry*; D011817:Rabbits; D013329:Structure-Activity Relationship; D001743:Urinary Bladder / Q000378:metabolism
chemical_list: D000880:Anthraquinones; D051036:Large-Conductance Calcium-Activated Potassium Channels; D026902:Potassium Channel Blockers