title: Label-free detection of DNA hybridization using transistors based on CVD grown graphene.
abstract: The high transconductance and low noise of graphene-based field-effect transistors based on large-area monolayer graphene produced by chemical vapor deposition are used for label-free electrical detection of DNA hybridization. The gate materials, buffer concentration and surface condition of graphene have been optimized to achieve the DNA detection sensitivity as low as 1 pM (10(-12) M), which is more sensitive than the existing report based on few-layer graphene. The graphene films obtained using conventional PMMA-assisted transfer technique exhibits PMMA residues, which degrade the sensing performance of graphene. We have demonstrated that the sensing performance of the graphene samples prepared by gold-transfer is largely enhanced (by 125%).
authors.affiliation: Institute of Atomic and Molecular Sciences, Academia Sinica, Taipei 10617, Taiwan.
authors.forename: Tzu-Yin
authors.initials: TY
authors.lastname: Chen
authors.forename: Phan Thi Kim
authors.initials: PT
authors.lastname: Loan
authors.forename: Chang-Lung
authors.initials: CL
authors.lastname: Hsu
authors.forename: Yi-Hsien
authors.initials: YH
authors.lastname: Lee
authors.forename: Jacob
authors.initials: J
authors.lastname: Tse-Wei Wang
authors.forename: Kung-Hwa
authors.initials: KH
authors.lastname: Wei
authors.forename: Cheng-Te
authors.initials: CT
authors.lastname: Lin
authors.forename: Lain-Jong
authors.initials: LJ
authors.lastname: Li
mesh_terms: D003217:Conductometry / Q000295:instrumentation*; D003460:Crystallization / Q000379:methods*; D004247:DNA / Q000032:analysis / Q000235:genetics*; D004566:Electrodes; D004867:Equipment Design; D019544:Equipment Failure Analysis; D005740:Gases / Q000737:chemistry; D006108:Graphite / Q000737:chemistry*; D009693:Nucleic Acid Hybridization / Q000235:genetics*; D020411:Oligonucleotide Array Sequence Analysis / Q000295:instrumentation*; D013194:Staining and Labeling; D014173:Transistors, Electronic
chemical_list: D005740:Gases; D006108:Graphite; D004247:DNA