title: The design of a heterocellular 3D architecture and its application to monitoring the behavior of cancer cells in response to the spatial distribution of endothelial cells.
abstract: The spatial cell distribution is one of the critical features for governing cellular interactions and their consequent behaviors. Here we suggest a novel method of building a hierarchical cellular structure by stacking cell-attached microplate structures with specific configurations within hydrogel layers. This method is applied to the reconstruction of the 3D architecture of a liver lobule and the development of an experimental model of the various phases of cancer angiogenesis.
authors.affiliation: Department of Neurosurgery, Stanford University, 300 Pasteur Drive, Stanford, CA 94305 USA. wjh@stanford.edu
authors.forename: Wonjae
authors.initials: W
authors.lastname: Lee
authors.forename: Jon
authors.initials: J
authors.lastname: Park
mesh_terms: D000818:Animals; D002450:Cell Communication; D045744:Cell Line, Tumor; D002470:Cell Survival; D042783:Endothelial Cells / Q000166:cytology*; D061307:Human Umbilical Vein Endothelial Cells; D006801:Humans; D020100:Hydrogels / Q000737:chemistry; D019344:Lactic Acid / Q000737:chemistry; D055616:Microtechnology / Q000379:methods*; D009369:Neoplasms / Q000473:pathology*; D011100:Polyglycolic Acid / Q000737:chemistry; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D051381:Rats
chemical_list: D020100:Hydrogels; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D011100:Polyglycolic Acid; D019344:Lactic Acid