title: Evaluation of a new single-piece 4% water content hydrophobic acrylic intraocular lens in the rabbit model.
abstract: OBJECTIVE
  To evaluate uveal and capsular biocompatibility of a 1-piece intraocular lens (IOL) manufactured from a new hydrophobic acrylic material that incorporates a barrier step at the optic-haptic junctions.
  
  
  METHODS
  John A. Moran Eye Center, University of Utah, Salt Lake City, Utah, USA.
  
  
  METHODS
  Experimental study.
  
  
  METHODS
  The study IOL (Eternity-Uni W-60) was implanted in the right eyes of 5 New Zealand rabbits and the control IOL (Acrysof SN60WF) in the left eyes. Slitlamp examination was performed 1 through 4 weeks postoperatively. After death, the globes were enucleated and fixed in formalin. Capsular bag opacification scoring (Miyake-Apple view) was then performed followed by complete histopathology.
  
  
  RESULTS
  At the 4-week examination, the mean posterior capsule opacification (PCO) score was 1.5 ± 1.0 (SD) in the study group and 2.2 ± 1.09 in the control group (P=.02). Anterior capsule opacification (ACO) was not present in the study eyes and was mild in the control eyes. On gross examination, the mean central PCO score was 0.9 ± 0.65 in the study group and 1.7 ± 1.20 in the control group (P=.07); the mean peripheral PCO score was 1.3 ± 0.67 and 2.4 ± 1.14 (P=.01) and the mean Soemmerring ring score was 3.8 ± 0.44 and 4.2 ± 1.09, respectively (P=.47). Histopathology confirmed that both IOLs were equally tolerated by the rabbit eyes.
  
  
  CONCLUSIONS
  In this rabbit study, the new hydrophobic acrylic material was biocompatible. The barrier step incorporated to the optic-haptic junctions has the potential to enhance PCO prevention.
authors.affiliation: Department of Ophthalmology and Visual Sciences, John A. Moran Eye Center, University of Utah, Salt Lake City, Utah 84132, USA.
authors.forename: Andrew
authors.initials: A
authors.lastname: Ollerton
authors.forename: Liliana
authors.initials: L
authors.lastname: Werner
authors.forename: Stanley R
authors.initials: SR
authors.lastname: Fuller
authors.forename: Shaheen C
authors.initials: SC
authors.lastname: Kavoussi
authors.forename: J Steele
authors.initials: JS
authors.lastname: McIntyre
authors.forename: Nick
authors.initials: N
authors.lastname: Mamalis
mesh_terms: D000180:Acrylic Resins; D000818:Animals; D001672:Biocompatible Materials; D058442:Capsule Opacification / Q000473:pathology / Q000517:prevention & control; D057927:Hydrophobic and Hydrophilic Interactions; D007903:Lens Capsule, Crystalline / Q000473:pathology; D019654:Lens Implantation, Intraocular; D007910:Lenses, Intraocular; D008422:Materials Testing; D008855:Microscopy, Electron, Scanning; D023421:Models, Animal; D018918:Phacoemulsification; D011474:Prosthesis Design; D011817:Rabbits; D014603:Uveal Diseases / Q000473:pathology / Q000517:prevention & control
chemical_list: D000180:Acrylic Resins; D001672:Biocompatible Materials