title: Hypoxia-induced factor-1α in endometrial carcinoma: a mini-review of current evidence.
abstract: Despite the well-established role of hypoxia in cancer biology, the literature on its effects on endometrial cancer is scarce; it mainly refers to experimental settings rather than patient-derived results. Herein, an overview of the hypoxia inducible factor 1α (HIF-1α) biology, focusing on endometrial cancer, is presented. The molecular mechanisms possibly involved in endometrial cancer progression are presented, followed by a systematic approach to the current literature on immunohistochemistry evaluation of HIF-1α expression in endometrial carcinoma. Since no consensus has been made regarding HIF-1α evaluation, the evidence of possible involvement of HIF-1α in endometrial carcinoma prognosis is weak. After a consensus has been made, properly powered studies may be able to clarify whether HIF-1α can act as a prognosticator in endometrial carcinoma.
authors.affiliation: Department of Obstetrics and Gynecology, Medical School, University of Ioannina, Ioannina, Greece.
authors.forename: Vassilis
authors.initials: V
authors.lastname: Dousias
authors.forename: Thomas
authors.initials: T
authors.lastname: Vrekoussis
authors.forename: Iordanis
authors.initials: I
authors.lastname: Navrozoglou
authors.forename: Minas
authors.initials: M
authors.lastname: Paschopoulos
authors.forename: Theodore
authors.initials: T
authors.lastname: Stefos
authors.forename: Antonis
authors.initials: A
authors.lastname: Makrigiannakis
authors.forename: Udo
authors.initials: U
authors.lastname: Jeschke
mesh_terms: D018450:Disease Progression; D016889:Endometrial Neoplasms / Q000209:etiology / Q000378:metabolism* / Q000473:pathology; D004717:Endometrium / Q000378:metabolism; D005260:Female; D006801:Humans; D000860:Hypoxia / Q000378:metabolism / Q000473:pathology; D051795:Hypoxia-Inducible Factor 1, alpha Subunit / Q000378:metabolism*; D007150:Immunohistochemistry; D053858:Metabolic Networks and Pathways; D011379:Prognosis
chemical_list: C497442:HIF1A protein, human; D051795:Hypoxia-Inducible Factor 1, alpha Subunit