title: Resveratrol prevents hepatic steatosis induced by hepatitis C virus core protein.
abstract: Hepatitis C virus (HCV) core protein plays an important role in the development of hepatic steatosis in patients with chronic HCV infection. Treatment of C57BL/6 mice infected with HCV core recombinant adenoviruses with resveratrol significantly decreased hepatic triacylglycerols (TAG) while the serum TAG level was unaffected. RT-PCR and Western blotting showed that HCV core protein attenuated the expression of Sirt1 and PPAR-α, which would be reversed by resveratrol. This was also confirmed in primary mouse hepatic cells infected with HCV core protein expressing adenovirus. Thus, resveratrol may prevent against hepatic steatosis by blocking the inhibited expression of Sirt1 and PPAR-α induced by HCV core protein.
authors.affiliation: State Key Laboratory of Cancer Biology and Department of Pathology, Xijing Hospital, Fourth Military Medical University, Xi'an, Shaanxi, China.
authors.forename: Lina
authors.initials: L
authors.lastname: Jiang
authors.forename: Yu
authors.initials: Y
authors.lastname: Gu
authors.forename: Jing
authors.initials: J
authors.lastname: Ye
authors.forename: Fang
authors.initials: F
authors.lastname: Liu
authors.forename: Yilin
authors.initials: Y
authors.lastname: Zhao
authors.forename: Chao
authors.initials: C
authors.lastname: Wang
authors.forename: Yuqiao
authors.initials: Y
authors.lastname: Xu
authors.forename: Xiangmei
authors.initials: X
authors.lastname: Cao
authors.forename: Liying
authors.initials: L
authors.lastname: Zhang
authors.forename: Wenpeng
authors.initials: W
authors.lastname: Dong
authors.forename: Fanfan
authors.initials: F
authors.lastname: Li
authors.forename: Jing
authors.initials: J
authors.lastname: Wang
authors.forename: Hui
authors.initials: H
authors.lastname: Wang
authors.forename: Qing
authors.initials: Q
authors.lastname: Li
mesh_terms: D000256:Adenoviridae / Q000235:genetics; D000818:Animals; D015153:Blotting, Western; D002478:Cells, Cultured; D005234:Fatty Liver / Q000139:chemically induced* / Q000517:prevention & control*; D005765:Gastrointestinal Agents / Q000008:administration & dosage*; D020869:Gene Expression Profiling; D005822:Genetic Vectors; D016174:Hepacivirus / Q000472:pathogenicity; D019698:Hepatitis C, Chronic / Q000150:complications; D022781:Hepatocytes / Q000502:physiology; D008099:Liver / Q000737:chemistry / Q000473:pathology; D051379:Mice; D008810:Mice, Inbred C57BL; D047493:PPAR alpha / Q000096:biosynthesis; D011994:Recombinant Proteins / Q000235:genetics / Q000633:toxicity; D000077185:Resveratrol; D020133:Reverse Transcriptase Polymerase Chain Reaction; D056564:Sirtuin 1 / Q000096:biosynthesis; D013267:Stilbenes / Q000008:administration & dosage*; D014280:Triglycerides / Q000032:analysis / Q000097:blood; D014758:Viral Core Proteins / Q000235:genetics / Q000633:toxicity*
chemical_list: D005765:Gastrointestinal Agents; D047493:PPAR alpha; D011994:Recombinant Proteins; D013267:Stilbenes; D014280:Triglycerides; D014758:Viral Core Proteins; C069130:nucleocapsid protein, Hepatitis C virus; C470545:Sirt1 protein, mouse; D056564:Sirtuin 1; D000077185:Resveratrol