title: Design and synthesis of a stable oxidized phospholipid mimic with specific binding recognition for macrophage scavenger receptors.
abstract: Macrophage scavenger receptors appear to play a major role in the clearance of oxidized phospholipid (OxPL) products. Discrete peptide-phospholipid conjugates with the phosphatidylcholine headgroup have been shown to exhibit binding affinity for these receptors. We report the preparation of a water-soluble, stable peptide-phospholipid conjugate (9) that possesses the necessary physical properties to enable more detailed study of the role(s) of OxPL in metabolic disease.
authors.affiliation: Department of Chemistry, Indiana University, Bloomington, Indiana 47405-7102, USA.
authors.forename: William W
authors.initials: WW
authors.lastname: Turner
authors.forename: Karsten
authors.initials: K
authors.lastname: Hartvigsen
authors.forename: Agnes
authors.initials: A
authors.lastname: Boullier
authors.forename: Erica N
authors.initials: EN
authors.lastname: Montano
authors.forename: Joseph L
authors.initials: JL
authors.lastname: Witztum
authors.forename: Michael S
authors.initials: MS
authors.lastname: VanNieuwenhze
mesh_terms: D000818:Animals; D000911:Antibodies, Monoclonal / Q000378:metabolism; D040761:Biomimetic Materials / Q000138:chemical synthesis* / Q000737:chemistry / Q000378:metabolism*; D018955:CD36 Antigens / Q000378:metabolism*; D060326:Chemistry Techniques, Synthetic; D015195:Drug Design; D004355:Drug Stability; D006801:Humans; D051379:Mice; D010084:Oxidation-Reduction; D010742:Phospholipid Ethers / Q000737:chemistry* / Q000378:metabolism; D011485:Protein Binding; D012995:Solubility; D013379:Substrate Specificity; D014867:Water / Q000737:chemistry
chemical_list: C400184:1-palmitoyl-2-(5-oxovaleroyl)-sn-glycero-3-phosphorylcholine; D000911:Antibodies, Monoclonal; D018955:CD36 Antigens; D010742:Phospholipid Ethers; D014867:Water