title: Photodynamic therapy of condyloma acuminata in pregnant women.
abstract: BACKGROUND
  Photodynamic therapy (PDT) with 5-aminolevulinic acid (ALA) is an emerging technique for the treatment of genital human papillomavirus (HPV)-induced benign and premalignant lesions. We report here in a case series of condyloma acuminata (CA) in pregnancy successfully treated with ALA-PDT.
  
  
  METHODS
  Five pregnant patients with CA received three to four times treatment respectively. Patients were followed up for 6 - 23 months after treatment.
  
  
  RESULTS
  The clearance rate of genital warts was 100%. No recurrence was found during the follow-up period. Major adverse events reported were mild erosion, pain, and local edema. All pregnancies resulted in healthy live births without delivery complications.
  
  
  CONCLUSIONS
  PDT with topical ALA seems to be safe and effective in the treatment of CA in pregnancy. It demonstrated high clearance rate of warts, was well-tolerated by patients, and showed no adverse effects on mothers or fetuses. ALA-PDT may be an ideal strategy of treatment for pregnant women with CA.
authors.affiliation: Department of Dermatology, Chinese People's Liberation Army General Hospital, Beijing 100853, China.
authors.forename: Yu-Guang
authors.initials: YG
authors.lastname: Yang
authors.forename: Xian-Biao
authors.initials: XB
authors.lastname: Zou
authors.forename: Hua
authors.initials: H
authors.lastname: Zhao
authors.forename: Yun-Jie
authors.initials: YJ
authors.lastname: Zhang
authors.forename: Heng-Jin
authors.initials: HJ
authors.lastname: Li
mesh_terms: D000328:Adult; D000622:Aminolevulinic Acid / Q000627:therapeutic use; D003218:Condylomata Acuminata / Q000188:drug therapy*; D005260:Female; D006801:Humans; D010778:Photochemotherapy / Q000379:methods*; D011247:Pregnancy
chemical_list: D000622:Aminolevulinic Acid