title: Benefits of early systemic antibiotics in localized aggressive periodontitis: a retrospective study.
abstract: BACKGROUND
  Treatment of localized aggressive periodontitis (LAP) may include systemic antibiotics, yet it is unclear at what stage of treatment planning antibiotics are most effective.
  
  
  OBJECTIVE
  This retrospective analysis compared immediate versus delayed antibiotic therapy on clinical parameters and gingival crevicular fluid (GCF) inflammatory mediators.
  
  
  METHODS
  At baseline, 3 months and 6 months after treatment, clinical parameters [probing depth (PD), clinical attachment level (CAL), bleeding on probing (BoP) and plaque] and GCF were collected from LAP participants, who received a 7-day antibiotic regimen immediately (ImA) or 3 months following (DelA) mechanical therapy.
  
  
  RESULTS
  Although both groups presented significant CAL reductions at 6 months, only ImA resulted in a reduction in mean PD at both 3 and 6 months, along with reductions in CAL and BoP at 3 months following therapy. In addition, GCF mediators were higher in DelA group at 3 months post mechanical treatment, but were significantly reduced 6 months following antibiotic therapy.
  
  
  CONCLUSIONS
  ImA and DelA regimens were both effective in improving CAL by 6 months post therapy. However, ImA allowed for better improvement in overall clinical parameters early in the course of treatment, concomitant with lower levels of inflammatory mediators within the GCF.
authors.affiliation: University of Florida, Gainesville, FL, USA.
authors.forename: Dennis
authors.initials: D
authors.lastname: Beliveau
authors.forename: Ingvar
authors.initials: I
authors.lastname: Magnusson
authors.forename: John A
authors.initials: JA
authors.lastname: Bidwell
authors.forename: Edward F
authors.initials: EF
authors.lastname: Zapert
authors.forename: Ikramuddin
authors.initials: I
authors.lastname: Aukhil
authors.forename: Shannon M
authors.initials: SM
authors.lastname: Wallet
authors.forename: Luciana M
authors.initials: LM
authors.lastname: Shaddox
mesh_terms: D000293:Adolescent; D001741:Black or African American; D010520:Aggressive Periodontitis / Q000188:drug therapy*; D000658:Amoxicillin / Q000627:therapeutic use*; D000890:Anti-Infective Agents / Q000627:therapeutic use*; D002648:Child; D002986:Clinical Trials as Topic; D003131:Combined Modality Therapy; D003777:Dental Prophylaxis / Q000379:methods*; D004334:Drug Administration Schedule; D004359:Drug Therapy, Combination; D005260:Female; D005883:Gingival Crevicular Fluid / Q000276:immunology; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D008795:Metronidazole / Q000627:therapeutic use*; D010512:Periodontal Index; D012189:Retrospective Studies; D013997:Time Factors; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D000890:Anti-Infective Agents; D008795:Metronidazole; D000658:Amoxicillin