title: [Destabilization of homeostasis of organism of burn patients as a marker of sepsis development, its complications and outcome].
abstract: OBJECTIVE
  Detection in burn patients of markers of sepsis development, its complications and outcome.
  
  
  METHODS
  Sera IL-6, TNF-alpha, IL-8, IL-1beta, IL-Ra, IL-18, INF-gamma, IL-10 and sTREM-1 cytokine levels of burn patients at days 3-6 and 10-17 after the burn were studied.
  
  
  RESULTS
  Statistically significant cytokine parameters in blood sera that already at the early stages of the burn disease may be markers of the course severity and sepsis outcome were obtained. At day 3-6 after the injury high level of IL-10 in blood sera may act as a lethal outcome marker in burn patients, and by day 10-17 after the burn high level of IL-6 becomes determinative. Low level of IL-1beta may serve as a marker of complicated course of sepsis in patients with favorable outcome already at days 3-6 after the injury.
  
  
  CONCLUSIONS
  Certain laboratory parameters of human organism homeostasis destabilization may be used as markers of sepsis development, its complications and outcome already in the initial period of burn disease in severe thermal injuries.
authors.forename: A L
authors.initials: AL
authors.lastname: Burmistrova
authors.forename: Iu Iu
authors.initials: IuIu
authors.lastname: Filippova
authors.forename: M I
authors.initials: MI
authors.lastname: Ugnivenko
authors.forename: D Iu
authors.initials: DIu
authors.lastname: Nokhrin
authors.forename: E P
authors.initials: EP
authors.lastname: Koneva
authors.forename: L I
authors.initials: LI
authors.lastname: Bakhareva
mesh_terms: D000150:Acinetobacter / Q000276:immunology / Q000472:pathogenicity; D000293:Adolescent; D000328:Adult; D015415:Biomarkers / Q000097:blood; D002056:Burns / Q000150:complications / Q000276:immunology* / Q000382:microbiology / Q000401:mortality; D015169:Colony Count, Microbial; D005260:Female; D006706:Homeostasis / Q000276:immunology*; D006801:Humans; D016753:Interleukin-10 / Q000097:blood* / Q000276:immunology; D053583:Interleukin-1beta / Q000097:blood* / Q000276:immunology; D015850:Interleukin-6 / Q000097:blood* / Q000276:immunology; D008297:Male; D008875:Middle Aged; D025341:Principal Component Analysis; D011379:Prognosis; D011550:Pseudomonas aeruginosa / Q000276:immunology / Q000472:pathogenicity; D018805:Sepsis / Q000150:complications / Q000276:immunology* / Q000382:microbiology / Q000401:mortality; D012720:Severity of Illness Index; D013211:Staphylococcus aureus / Q000276:immunology / Q000472:pathogenicity; D015996:Survival Rate
chemical_list: D015415:Biomarkers; D053583:Interleukin-1beta; D015850:Interleukin-6; D016753:Interleukin-10