title: hnRNP Q regulates translation of p53 in normal and stress conditions.
abstract: The responses to numerous stress signals are important for cellular growth and survival. The p53 tumor-suppressor protein is stabilized under stress conditions and induces transcription of several genes to regulate cell cycle and apoptosis. Regarding p53 protein accumulation, inhibition of proteasomal degradation of p53 protein, which is mainly mediated by Mdm2, has received much attention. Here, we demonstrate that regulation of translation initiation is also crucial for p53 protein accumulation. Furthermore, we report that heterogeneous nuclear ribonucleoprotein (hnRNP) Q binds to the 5'-untranslated region (UTR) of mouse p53 mRNA and regulates translation efficiency of p53 and apoptosis progression. We also suggest that changes in cytosolic hnRNP Q levels contribute to cell cycle-dependent translational differences in p53 mRNA.
authors.affiliation: Department of Life Science, Division of Molecular and Life Science, Pohang University of Science and Technology, Pohang, Gyeong-Buk, Republic of Korea.
authors.forename: D-Y
authors.initials: DY
authors.lastname: Kim
authors.forename: W
authors.initials: W
authors.lastname: Kim
authors.forename: K-H
authors.initials: KH
authors.lastname: Lee
authors.forename: S-H
authors.initials: SH
authors.lastname: Kim
authors.forename: H-R
authors.initials: HR
authors.lastname: Lee
authors.forename: H-J
authors.initials: HJ
authors.lastname: Kim
authors.forename: Y
authors.initials: Y
authors.lastname: Jung
authors.forename: J-H
authors.initials: JH
authors.lastname: Choi
authors.forename: K-T
authors.initials: KT
authors.lastname: Kim
mesh_terms: D020121:5' Untranslated Regions; D000818:Animals; D017209:Apoptosis; D003593:Cytoplasm / Q000378:metabolism; D005786:Gene Expression Regulation; D034441:Heterogeneous-Nuclear Ribonucleoproteins / Q000037:antagonists & inhibitors / Q000235:genetics / Q000378:metabolism*; D006801:Humans; D007700:Kinetics; D051379:Mice; D041681:NIH 3T3 Cells; D034622:RNA Interference; D012333:RNA, Messenger / Q000378:metabolism; D034741:RNA, Small Interfering / Q000378:metabolism; D016159:Tumor Suppressor Protein p53 / Q000235:genetics / Q000378:metabolism*
chemical_list: D020121:5' Untranslated Regions; D034441:Heterogeneous-Nuclear Ribonucleoproteins; D012333:RNA, Messenger; D034741:RNA, Small Interfering; C486049:Syncrip protein, mouse; D016159:Tumor Suppressor Protein p53