title: Association of the PSCA rs2294008 C>T polymorphism with gastric cancer risk: evidence from a meta-analysis.
abstract: BACKGROUND
  Multiple studies have reported associations between the PSCA rs2294008 C>T polymorphism and GC, but susceptibility has proven inconsistent. Therefore, we estimates the relationship between the rs2294008 C>T polymorphism and GC by meta-analysis.
  
  
  METHODS
  PubMed, Embase and Web of Science databases were searched and nine independent case-control studies were included in this meta- analysis. Crude ORs with 95% CIs were extracted according to the Mantal-Haenszel method and pooled to assess the strength of the association.
  
  
  RESULTS
  We observed that the PSCA rs2294008 C>T polymorphism was significantly correlated with GC risk when all studies were pooled into the meta-analysis. Further subgroup analysis showed the polymorphism to be linked with diffuse and noncardia GC in the allele contrast model, homozygote codominant model, dominant model, and recessive model. However, no connection was apparent for intestinal and cardia GC. In the stratified analysis by ethnicity, significant associations were observed in Asians for the recessive model. Interestingly, the relationship was particularly significant in the Chinese population.
  
  
  CONCLUSIONS
  Our findings suggest that the PSCA rs2294008 C>T polymorphism is a risk factor for GC, especially in diffuse and noncardia GC and in Chinese.
authors.affiliation: Department of Clinical Laboratory, Kunshan First People's Hospital, Affiliated to Jiangsu University, Kunshan, Jiangsu, China. zhangqinghui1983@126.com
authors.forename: Qing-Hui
authors.initials: QH
authors.lastname: Zhang
authors.forename: Yong-Liang
authors.initials: YL
authors.lastname: Yao
authors.forename: Tao
authors.initials: T
authors.lastname: Gu
authors.forename: Jin-Hua
authors.initials: JH
authors.lastname: Gu
authors.forename: Ling
authors.initials: L
authors.lastname: Chen
authors.forename: Yun
authors.initials: Y
authors.lastname: Liu
mesh_terms: D000951:Antigens, Neoplasm / Q000235:genetics*; D016022:Case-Control Studies; D002681:China; D058851:GPI-Linked Proteins / Q000235:genetics; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D009363:Neoplasm Proteins / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D012306:Risk; D013274:Stomach Neoplasms / Q000235:genetics*
chemical_list: D000951:Antigens, Neoplasm; D058851:GPI-Linked Proteins; D009363:Neoplasm Proteins; C110843:PSCA protein, human