title: Tox-database.net: a curated resource for data describing chemical triggered in vitro cardiac ion channels inhibition.
abstract: BACKGROUND
  Drugs safety issues are now recognized as being factors generating the most reasons for drug withdrawals at various levels of development and at the post-approval stage. Among them cardiotoxicity remains the main reason, despite the substantial effort put into in vitro and in vivo testing, with the main focus put on hERG channel inhibition as the hypothesized surrogate of drug proarrhythmic potency. The large interest in the IKr current has resulted in the development of predictive tools and informative databases describing a drug's susceptibility to interactions with the hERG channel, although there are no similar, publicly available sets of data describing other ionic currents driven by the human cardiomyocyte ionic channels, which are recognized as an overlooked drug safety target.
  
  
  CONCLUSIONS
  The aim of this database development and publication was to provide a scientifically useful, easily usable and clearly verifiable set of information describing not only IKr (hERG), but also other human cardiomyocyte specific ionic channels inhibition data (IKs, INa, ICa).
  
  
  CONCLUSIONS
  The broad range of data (chemical space and in vitro settings) and the easy to use user interface makes tox-database.net a useful tool for interested scientists. DATABASE URL: http://tox-database.net.
authors.affiliation: Unit of Pharmacoepidemiology and Pharmacoeconomics, Faculty of Pharmacy Jagiellonian University Medical College, Medyczna 9 Street, 30-688 Krakow, Poland. spolak@cm-uj.krakow.pl
authors.forename: Sebastian
authors.initials: S
authors.lastname: Polak
authors.forename: Barbara
authors.initials: B
authors.lastname: Wiśniowska
authors.forename: Anna
authors.initials: A
authors.lastname: Glinka
authors.forename: Miłosz
authors.initials: M
authors.lastname: Polak
mesh_terms: D054715:Cardiotoxins / Q000633:toxicity*; D016208:Databases, Factual; D064420:Drug-Related Side Effects and Adverse Reactions; D006801:Humans; D007473:Ion Channels / Q000037:antagonists & inhibitors* / Q000502:physiology; D032383:Myocytes, Cardiac / Q000502:physiology*
chemical_list: D054715:Cardiotoxins; D007473:Ion Channels