title: [Implementation of VarioGuide in stereotactic brain biopsy: a preliminary experience].
abstract: OBJECTIVE
  To evaluate the clinical value of VarioGuide in stereotactic brain biopsy.
  
  
  METHODS
  Fifteen patients with brain lesions underwent frameless stereotactic brain biopsy guided by VarioGuide and multimodal neuronavigation. Intraoperative magnetic resonance imaging (iMRI) was used to confirm the accuracy of biopsy. And the VarioGuide-related adverse events, operative duration, surgical outcomes and postoperative complications were recorded respectively.
  
  
  RESULTS
  In all patients, VarioGuide and multimodal neuronavigation were successfully integrated into the biopsy procedure. No VarioGuide-related adverse events were reported. The mean operative duration was (65 ± 8) min. The biopsy accuracy was confirmed by iMRI in all cases. And the postoperative histological diagnostic rate was 100%. No mortality and morbidity occurred postoperatively.
  
  
  CONCLUSIONS
  The combined approach of VarioGuide and multimodal neuronavigation is accurate, safe and efficient. It may improve the histological diagnostic rate without postoperative neurological deficits in stereotactic brain biopsy.
authors.affiliation: Department of Neurosurgery, PLA General Hospital, Beijing 100853, China.
authors.forename: Jia-shu
authors.initials: JS
authors.lastname: Zhang
authors.forename: Xiao-lei
authors.initials: XL
authors.lastname: Chen
authors.forename: Fang-ye
authors.initials: FY
authors.lastname: Li
authors.forename: Jin-jiang
authors.initials: JJ
authors.lastname: Li
authors.forename: Gang
authors.initials: G
authors.lastname: Zheng
authors.forename: Ting
authors.initials: T
authors.lastname: Zhang
authors.forename: Shen
authors.initials: S
authors.lastname: Hu
authors.forename: Bai-nan
authors.initials: BN
authors.lastname: Xu
mesh_terms: D000293:Adolescent; D000328:Adult; D001706:Biopsy / Q000379:methods*; D001921:Brain / Q000473:pathology*; D002648:Child; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D038361:Neuronavigation; D013238:Stereotaxic Techniques; D055815:Young Adult