title: Use and interpretation of diagnostic vaccination in primary immunodeficiency: a working group report of the Basic and Clinical Immunology Interest Section of the American Academy of Allergy, Asthma & Immunology.
abstract: A major diagnostic intervention in the consideration of many patients suspected to have primary immunodeficiency diseases (PIDDs) is the application and interpretation of vaccination. Specifically, the antibody response to antigenic challenge with vaccines can provide substantive insight into the status of human immune function. There are numerous vaccines that are commonly used in healthy individuals, as well as others that are available for specialized applications. Both can potentially be used to facilitate consideration of PIDD. However, the application of vaccines and interpretation of antibody responses in this context are complex. These rely on consideration of numerous existing specific studies, interpolation of data from healthy populations, current diagnostic guidelines, and expert subspecialist practice. This document represents an attempt of a working group of the American Academy of Allergy, Asthma & Immunology to provide further guidance and synthesis in this use of vaccination for diagnostic purposes in consideration of PIDD, as well as to identify key areas for further research.
authors.affiliation: Baylor College of Medicine, Texas Children's Hospital, Houston, TX 77030, USA. orange@bcm.edu
authors.forename: Jordan S
authors.initials: JS
authors.lastname: Orange
authors.forename: Mark
authors.initials: M
authors.lastname: Ballow
authors.forename: E Richard
authors.initials: ER
authors.lastname: Stiehm
authors.forename: Zuhair K
authors.initials: ZK
authors.lastname: Ballas
authors.forename: Javier
authors.initials: J
authors.lastname: Chinen
authors.forename: Maite
authors.initials: M
authors.lastname: De La Morena
authors.forename: Dinakantha
authors.initials: D
authors.lastname: Kumararatne
authors.forename: Terry O
authors.initials: TO
authors.lastname: Harville
authors.forename: Paul
authors.initials: P
authors.lastname: Hesterberg
authors.forename: Majed
authors.initials: M
authors.lastname: Koleilat
authors.forename: Sean
authors.initials: S
authors.lastname: McGhee
authors.forename: Elena E
authors.initials: EE
authors.lastname: Perez
authors.forename: Jason
authors.initials: J
authors.lastname: Raasch
authors.forename: Rebecca
authors.initials: R
authors.lastname: Scherzer
authors.forename: Harry
authors.initials: H
authors.lastname: Schroeder
authors.forename: Christine
authors.initials: C
authors.lastname: Seroogy
authors.forename: Aarnoud
authors.initials: A
authors.lastname: Huissoon
authors.forename: Ricardo U
authors.initials: RU
authors.lastname: Sorensen
authors.forename: Rohit
authors.initials: R
authors.lastname: Katial
mesh_terms: D016667:Bacterial Capsules / Q000276:immunology; D010584:Bacteriophage phi X 174 / Q000276:immunology; D018073:Haemophilus Vaccines / Q000276:immunology; D006801:Humans; D056724:Immunity, Humoral; D007153:Immunologic Deficiency Syndromes / Q000175:diagnosis / Q000276:immunology*; D022242:Pneumococcal Vaccines / Q000276:immunology; D011819:Rabies Vaccines / Q000276:immunology; D022562:Salmonella Vaccines / Q000276:immunology; D014611:Vaccination
chemical_list: D018073:Haemophilus Vaccines; C044237:Haemophilus influenzae type b polysaccharide vaccine; D022242:Pneumococcal Vaccines; D011819:Rabies Vaccines; D022562:Salmonella Vaccines