title: Innovations in phenotyping of mouse models in the German Mouse Clinic.
abstract: Under the label of the German Mouse Clinic (GMC), a concept has been developed and implemented that allows the better understanding of human diseases on the pathophysiological and molecular level. This includes better understanding of the crosstalk between different organs, pleiotropy of genes, and the systemic impact of envirotypes and drugs. In the GMC, experts from various fields of mouse genetics and physiology, in close collaboration with clinicians, work side by side under one roof. The GMC is an open-access platform for the scientific community by providing phenotypic analysis in bilateral collaborations ("bottom-up projects") and as a partner and driver in international large-scale biology projects ("top-down projects"). Furthermore, technology development is a major topic in the GMC. Innovative techniques for primary and secondary screens are developed and implemented into the phenotyping pipelines (e.g., detection of volatile organic compounds, VOCs).
authors.affiliation: German Mouse Clinic, Institute of Experimental Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health (GmbH), Ingolstädter Landstrasse 1, 85764 Neuherberg/Munich, Germany.
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authors.lastname: Neschen
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authors.lastname: Adler
authors.forename: Luciana Caminha
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authors.forename: Juan Antonio
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authors.forename: Sabine M
authors.initials: SM
authors.lastname: Hölter
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authors.lastname: Horsch
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authors.forename: Eva
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authors.lastname: Janik
authors.forename: Melanie
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authors.lastname: Kistler
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authors.lastname: Marschall
authors.forename: Kateryna
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authors.forename: Gabriele
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authors.forename: Beatrix
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authors.forename: Ildikó
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authors.lastname: Räss
authors.forename: Birgit
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authors.lastname: Rathkolb
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authors.lastname: Rozman
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authors.lastname: Scheerer
authors.forename: Evelyn
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authors.forename: Anja
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authors.lastname: Steinkamp
authors.forename: Claudia
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authors.forename: Minxuan
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authors.lastname: Sun
authors.forename: Wilfried
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authors.lastname: Szymczak
authors.forename: Irina
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authors.lastname: Treise
authors.forename: Ingrid Liliana
authors.initials: IL
authors.lastname: Vargas Panesso
authors.forename: Alexandra M
authors.initials: AM
authors.lastname: Vernaleken
authors.forename: Monja
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authors.lastname: Willershäuser
authors.forename: Annemarie
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authors.lastname: Wolff-Muscate
authors.forename: Ramona
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authors.lastname: Zeh
authors.forename: Jerzy
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authors.lastname: Adamski
authors.forename: Johannes
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authors.lastname: Beckers
authors.forename: Raffi
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authors.lastname: Bekeredjian
authors.forename: Dirk H
authors.initials: DH
authors.lastname: Busch
authors.forename: Oliver
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authors.lastname: Eickelberg
authors.forename: Jack
authors.initials: J
authors.lastname: Favor
authors.forename: Jochen
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authors.lastname: Graw
authors.forename: Heinz
authors.initials: H
authors.lastname: Höfler
authors.forename: Christoph
authors.initials: C
authors.lastname: Höschen
authors.forename: Hugo
authors.initials: H
authors.lastname: Katus
authors.forename: Martin
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authors.lastname: Klingenspor
authors.forename: Thomas
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authors.lastname: Klopstock
authors.forename: Frauke
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authors.lastname: Neff
authors.forename: Markus
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authors.lastname: Ollert
authors.forename: Holger
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authors.lastname: Schulz
authors.forename: Tobias
authors.initials: T
authors.lastname: Stöger
authors.forename: Eckhard
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authors.lastname: Wolf
authors.forename: Wolfgang
authors.initials: W
authors.lastname: Wurst
authors.forename: Ali Önder
authors.initials: AÖ
authors.lastname: Yildirim
authors.forename: Andreas
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authors.lastname: Zimmer
authors.forename: Martin
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authors.lastname: Hrabě de Angelis
mesh_terms: D000818:Animals; D005858:Germany; D051379:Mice; D023421:Models, Animal; D010641:Phenotype