title: Mesenchymal dental stem cells in regenerative dentistry.
abstract: In the last decade, tissue engineering is a field that has been suffering an enormous expansion in the regenerative medicine and dentistry. The use of cells as mesenchymal dental stem cells of easy access for dentist and oral surgeon, immunosuppressive properties, high proliferation and capacity to differentiate into odontoblasts, cementoblasts, osteoblasts and other cells implicated in the teeth, suppose a good perspective of future in the clinical dentistry. However, is necessary advance in the known of growth factors and signalling molecules implicated in tooth development and regeneration of different structures of teeth. Furthermore, these cells need a fabulous scaffold that facility their integration, differentiation, matrix synthesis and promote multiple specific interactions between cells. In this review, we give a brief description of tooth development and anatomy, definition and classification of stem cells, with special attention of mesenchymal stem cells, commonly used in the cellular therapy for their trasdifferentiation ability, non ethical problems and acceptable results in preliminary clinical trials. In terms of tissue engineering, we provide an overview of different types of mesenchymal stem cells that have been isolated from teeth, including dental pulp stem cells (DPSCs), stem cells from human exfoliated deciduous teeth (SHEDs), periodontal ligament stem cells (PDLSCs), dental follicle progenitor stem cells (DFPCs), and stem cells from apical papilla (SCAPs), growth factors implicated in regeneration teeth and types of scaffolds for dental tissue regeneration.
authors.affiliation: Servicio de Hematología y Hemoterapia, Unidad de Trasplante Hematopoyético y Terapia Celular, Hospital Universitario Virgen de Arrixaca, Ctra. Madrid-Cartagena, El Palmar 3, 0120 Murcia, Spain. fcojavier@um.es
authors.forename: Francisco-Javier
authors.initials: FJ
authors.lastname: Rodríguez-Lozano
authors.forename: Carmen-Luisa
authors.initials: CL
authors.lastname: Insausti
authors.forename: Francisca
authors.initials: F
authors.lastname: Iniesta
authors.forename: Miguel
authors.initials: M
authors.lastname: Blanquer
authors.forename: María-del-Carmen
authors.initials: MD
authors.lastname: Ramírez
authors.forename: Luis
authors.initials: L
authors.lastname: Meseguer
authors.forename: Ana-Belén
authors.initials: AB
authors.lastname: Meseguer-Henarejos
authors.forename: Noemí
authors.initials: N
authors.lastname: Marín
authors.forename: Salvador
authors.initials: S
authors.lastname: Martínez
authors.forename: José-María
authors.initials: JM
authors.lastname: Moraleda
mesh_terms: D003813:Dentistry / Q000379:methods*; D006801:Humans; D059630:Mesenchymal Stem Cells; D044968:Regenerative Medicine / Q000379:methods*; D023822:Tissue Engineering / Q000379:methods*; D014070:Tooth / Q000166:cytology*