title: Alternative Wnt pathways and receptors.
abstract: In addition to activating β-catenin/TCF transcriptional complexes, Wnt proteins can elicit a variety of other responses. These are often lumped together under the denominator "alternative" or "non-canonical" Wnt signaling, but they likely comprise distinct signaling events. In this article, I discuss how the use of different ligand and receptor combinations is thought to give rise to these alternative Wnt-signaling responses. Although many of the biochemical details remain to be resolved, it is evident that alternative Wnt signaling plays important roles in regulating tissue morphogenesis during embryonic development.
authors.affiliation: Department of Developmental Biology, Stanford University, Stanford, California 94305, USA. r.v.amerongen@nki.nl
authors.forename: Renée
authors.initials: R
authors.lastname: van Amerongen
mesh_terms: D048868:Adaptor Proteins, Signal Transducing / Q000235:genetics / Q000378:metabolism / Q000502:physiology; D000818:Animals; D016764:Cell Polarity / Q000235:genetics; D000072261:Dishevelled Proteins; D051157:Frizzled Receptors / Q000235:genetics / Q000378:metabolism / Q000502:physiology; D018507:Gene Expression Regulation, Developmental; D008024:Ligands; D010750:Phosphoproteins / Q000235:genetics / Q000378:metabolism / Q000502:physiology; D060490:Receptors, Wnt / Q000502:physiology*; D014714:Vertebrates / Q000378:metabolism; D060449:Wnt Signaling Pathway / Q000502:physiology*
chemical_list: D048868:Adaptor Proteins, Signal Transducing; D000072261:Dishevelled Proteins; D051157:Frizzled Receptors; D008024:Ligands; D010750:Phosphoproteins; D060490:Receptors, Wnt