title: [Gene and environmental interactions of food allergy].
abstract: Food allergy is now looming as a major health issue with significant implications. In westernized countries, recent reports show a rise in allergic diseases, in particular food allergy. It affects approximately 5-8% of children and 1-5% of adults. Despite this, our current understanding of the immunological and biological mechanisms of food allergy is still incomplete. It is generally believed that food allergy is determined by both genetic and environmental factors. There is some evidence that epigenetic modifications may affect the prevalence of food allergies. This paper discusses the current state of knowledge regarding genetic, epigenetic and environmental factors of food allergy.
authors.affiliation: Katedra i Klinika Alergologii, Immunologii Klinicznej i Chorób Wewnętrznych, Collegum Medicum w Bydgoszczy, Uniwersytet Mikołaja Kopernika w Toruniu. palgank@wp.pl
authors.forename: Krzysztof
authors.initials: K
authors.lastname: Pałgan
authors.forename: Zbigniew
authors.initials: Z
authors.lastname: Bartuzi
mesh_terms: D001942:Breast Feeding; D015984:Causality; D002762:Cholecalciferol / Q000378:metabolism; D004781:Environmental Exposure; D057890:Epigenomics; D000091344:Filaggrin Proteins; D005492:Folic Acid / Q000378:metabolism; D005512:Food Hypersensitivity / Q000453:epidemiology* / Q000235:genetics* / Q000378:metabolism; D051858:Forkhead Transcription Factors / Q000378:metabolism; D059647:Gene-Environment Interaction; D006801:Humans; D007381:Intermediate Filament Proteins / Q000378:metabolism; D030821:Plants, Genetically Modified; D011110:Polymorphism, Genetic; D015995:Prevalence; D053491:Proteinase Inhibitory Proteins, Secretory / Q000378:metabolism; D050800:STAT6 Transcription Factor / Q000378:metabolism; D000074163:Serine Peptidase Inhibitor Kazal-Type 5
chemical_list: C418974:FOXP3 protein, human; D000091344:Filaggrin Proteins; D051858:Forkhead Transcription Factors; D007381:Intermediate Filament Proteins; D053491:Proteinase Inhibitory Proteins, Secretory; C120650:SPINK5 protein, human; D050800:STAT6 Transcription Factor; C494101:STAT6 protein, human; D000074163:Serine Peptidase Inhibitor Kazal-Type 5; D002762:Cholecalciferol; D005492:Folic Acid