title: Acetylcholine for male LUTS.
abstract: In this review, we present the evidence on the safety and efficacy of anticholinergic therapy for men with lower urinary tract symptoms (LUTS) secondary to benign prostatic hyperplasia (BPH) and emphasize the data published over the past year. This review discusses two classes of medications whose mechanism of action attenuates the effect of acetylcholine on the LUT: anticholinergics and botulinum toxin. We review the randomized controlled trials that investigate the efficacy and side effects of anticholinergics when used in men with LUTS secondary to BPH. We emphasize new studies and developments that have been made in the past year.
authors.affiliation: James Buchanan Brady Department of Urology, Weill Cornell Medical College of Cornell University, New York, NY 10065, USA.
authors.forename: Steven J
authors.initials: SJ
authors.lastname: Weissbart
authors.forename: Bilal
authors.initials: B
authors.lastname: Chughtai
authors.forename: Dean
authors.initials: D
authors.lastname: Elterman
authors.forename: Richard
authors.initials: R
authors.lastname: Lee
authors.forename: Alexis
authors.initials: A
authors.lastname: Te
authors.forename: Steven
authors.initials: S
authors.lastname: Kaplan
mesh_terms: D000109:Acetylcholine / Q000627:therapeutic use*; D018679:Cholinergic Agonists / Q000627:therapeutic use*; D004359:Drug Therapy, Combination; D006801:Humans; D059411:Lower Urinary Tract Symptoms / Q000188:drug therapy* / Q000209:etiology; D008297:Male; D011470:Prostatic Hyperplasia / Q000150:complications; D016032:Randomized Controlled Trials as Topic
chemical_list: D018679:Cholinergic Agonists; D000109:Acetylcholine