title: Reduced pulmonary surfactant interaction of daptomycin analogs via tryptophan replacement with alternative amino acids.
abstract: Daptomycin was shown to interact in vitro with pulmonary surfactant leading to reduction of its antibacterial activity. We report herein the preparation and anti-staphylococcal activity of a series of daptomycin analogs with reduced pulmonary surfactant interaction by replacing tryptophan with various amino acids.
authors.affiliation: Cubist Pharmaceuticals, 65 Hyden Ave, Lexington, MA 02421, United States. yong.he@cubist.com
authors.forename: Yong
authors.initials: Y
authors.lastname: He
authors.forename: Jing
authors.initials: J
authors.lastname: Li
authors.forename: Nin
authors.initials: N
authors.lastname: Yin
authors.forename: Prudencio S
authors.initials: PS
authors.lastname: Herradura
authors.forename: Larry
authors.initials: L
authors.lastname: Martel
authors.forename: Yanzhi
authors.initials: Y
authors.lastname: Zhang
authors.forename: Andre L
authors.initials: AL
authors.lastname: Pearson
authors.forename: Vidya
authors.initials: V
authors.lastname: Kulkarni
authors.forename: Carmela
authors.initials: C
authors.lastname: Mascio
authors.forename: Karen
authors.initials: K
authors.lastname: Howland
authors.forename: Jared A
authors.initials: JA
authors.lastname: Silverman
authors.forename: Dennis D
authors.initials: DD
authors.lastname: Keith
authors.forename: Chester A
authors.initials: CA
authors.lastname: Metcalf
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry* / Q000494:pharmacology*; D017576:Daptomycin / Q000031:analogs & derivatives* / Q000737:chemistry / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D008968:Molecular Conformation; D011663:Pulmonary Surfactants / Q000737:chemistry*; D013211:Staphylococcus aureus / Q000187:drug effects*; D014364:Tryptophan / Q000378:metabolism*
chemical_list: D000900:Anti-Bacterial Agents; D011663:Pulmonary Surfactants; D014364:Tryptophan; D017576:Daptomycin