title: Prevalence and risk factors for cervical HPV infection and abnormalities in young adult women at enrolment in the multinational PATRICIA trial.
abstract: OBJECTIVE
  We evaluated baseline data from the PApilloma TRIal against Cancer In young Adults (PATRICIA; NCT00122681) on the association between behavioral risk factors and HPV infection and cervical abnormalities.
  
  
  METHODS
  Women completed behavioral questionnaires at baseline. Prevalence of HPV infection and cervical abnormalities (detected by cytological or histological procedures) and association with behavioral risk factors were analyzed by univariate and stepwise multivariable logistic regressions.
  
  
  RESULTS
  16782 women completed questionnaires. Among 16748 women with data for HPV infection, 4059 (24.2%) were infected with any HPV type. Among 16757 women with data for cytological abnormalities, 1626 (9.7%) had a cytological abnormality, of whom 1170 (72.0%) were infected with at least one oncogenic HPV type including HPV-16 (22.7%) and HPV-18 (9.3%). Multivariable analysis (adjusted for age and region, N=14404) showed a significant association between infection with any HPV type and not living with a partner, smoking, age <15 years at first sexual intercourse, higher number of sexual partners during the past 12 months, longer duration of hormonal contraception and history of sexually transmitted infection (STI). For cervical abnormalities, only history of STI (excluding Chlamydia trachomatis) remained significant in the multivariable analysis after adjusting for HPV infection.
  
  
  CONCLUSIONS
  Women reporting 3+ sexual partners in the past 12 months had the highest risk of HPV infection at baseline. HPV infection was the main risk factor for cervical abnormalities, and history of STIs excluding Chlamydia trachomatis increased risk to a lesser extent. Although behavioral factors can influence risk, all sexually active women are susceptible to HPV infection.
authors.affiliation: GlaxoSmithKline Vaccines, Wavre, Belgium. edith.y.roset-bahmanyar@gsk.com
authors.forename: Edith
authors.initials: E
authors.lastname: Roset Bahmanyar
authors.forename: Jorma
authors.initials: J
authors.lastname: Paavonen
authors.forename: Paulo
authors.initials: P
authors.lastname: Naud
authors.forename: Jorge
authors.initials: J
authors.lastname: Salmerón
authors.forename: Song-Nan
authors.initials: SN
authors.lastname: Chow
authors.forename: Dan
authors.initials: D
authors.lastname: Apter
authors.forename: Henry
authors.initials: H
authors.lastname: Kitchener
authors.forename: Xavier
authors.initials: X
authors.lastname: Castellsagué
authors.forename: Julio C
authors.initials: JC
authors.lastname: Teixeira
authors.forename: S Rachel
authors.initials: SR
authors.lastname: Skinner
authors.forename: Unnop
authors.initials: U
authors.lastname: Jaisamrarn
authors.forename: Genara A
authors.initials: GA
authors.lastname: Limson
authors.forename: Suzanne M
authors.initials: SM
authors.lastname: Garland
authors.forename: Anne
authors.initials: A
authors.lastname: Szarewski
authors.forename: Barbara
authors.initials: B
authors.lastname: Romanowski
authors.forename: Fred
authors.initials: F
authors.lastname: Aoki
authors.forename: Tino F
authors.initials: TF
authors.lastname: Schwarz
authors.forename: Willy A J
authors.initials: WA
authors.lastname: Poppe
authors.forename: Newton S
authors.initials: NS
authors.lastname: De Carvalho
authors.forename: Diane M
authors.initials: DM
authors.lastname: Harper
authors.forename: F Xavier
authors.initials: FX
authors.lastname: Bosch
authors.forename: Alice
authors.initials: A
authors.lastname: Raillard
authors.forename: Dominique
authors.initials: D
authors.lastname: Descamps
authors.forename: Frank
authors.initials: F
authors.lastname: Struyf
authors.forename: Matti
authors.initials: M
authors.lastname: Lehtinen
authors.forename: Gary
authors.initials: G
authors.lastname: Dubin
mesh_terms: D000293:Adolescent; D000328:Adult; D002584:Cervix Uteri / Q000473:pathology* / Q000821:virology; D005260:Female; D006801:Humans; D016015:Logistic Models; D030361:Papillomavirus Infections / Q000453:epidemiology* / Q000209:etiology* / Q000517:prevention & control / Q000821:virology; D053918:Papillomavirus Vaccines; D015995:Prevalence; D012307:Risk Factors; D002577:Uterine Cervical Diseases / Q000453:epidemiology* / Q000209:etiology* / Q000517:prevention & control / Q000821:virology; D002583:Uterine Cervical Neoplasms / Q000517:prevention & control*; D014611:Vaccination; D055815:Young Adult
chemical_list: D053918:Papillomavirus Vaccines