title: The zebrafish as a model for paediatric diseases.
abstract: The rapid increase in information about genes and their associations with human diseases has highlighted the need for model organisms suitable for genetic manipulation and drug testing. The zebrafish is a valuable vertebrate animal model that offers many advantages, including the relative ease of husbandry and genetic manipulation and the capacity for high-throughput screens. In this review, we describe the zebrafish as a model for paediatric diseases, with particular emphasis on haematopoietic and infectious diseases.
  
  
  CONCLUSIONS
  The zebrafish has become an established vertebrate model in which to elucidate the molecular mechanisms of various human diseases.
authors.affiliation: Paediatric Research Centre, University of Tampere Medical School and Tampere University Hospital, Tampere, Finland.
authors.forename: Olli
authors.initials: O
authors.lastname: Lohi
authors.forename: Mataleena
authors.initials: M
authors.lastname: Parikka
authors.forename: Mika
authors.initials: M
authors.lastname: Rämet
mesh_terms: D000818:Animals; D003141:Communicable Diseases / Q000276:immunology / Q000382:microbiology; D004195:Disease Models, Animal; D007938:Leukemia / Q000235:genetics / Q000378:metabolism; D010372:Pediatrics; D015027:Zebrafish / Q000097:blood / Q000276:immunology