title: Characteristics of systemic diseases in the breast: clinical, imaging and pathologic features.
abstract: Despite tremendous efforts placed on advances in diagnosis and treatment of the spectrum of breast disease, the impact of systemic diseases on the breast has remained under recognized. Distinction between a variety of benign breast diseases versus those that are manifestations of a systemic disease is critically important for appropriate treatment planning and follow-up of patients. This article is designed to provide an overview of different systemic diseases that can present as a breast lesion. Attempts are made to highlight the significance of the distinction between benign breast disease versus benign conditions that present as the result of a systemic disease. Naturally, distinction between any benign condition versus breast carcinoma is a part of the evaluation process.
authors.affiliation: Department of Pathology, University of Florida College of Medicine-Jacksonville, Jacksonville, FL, USA. shahla.masood@jax.ufl.edu
authors.forename: Shahla
authors.initials: S
authors.lastname: Masood
mesh_terms: D001327:Autoimmune Diseases / Q000150:complications / Q000175:diagnosis / Q000473:pathology*; D001943:Breast Neoplasms / Q000175:diagnosis / Q000209:etiology / Q000473:pathology* / Q000556:secondary / Q000628:therapy; D003141:Communicable Diseases; D055088:Early Detection of Cancer; D005260:Female; D006293:Health Promotion / Q000592:standards*; D006402:Hematologic Diseases; D006801:Humans; D007150:Immunohistochemistry; D008232:Lymphoproliferative Disorders; D008279:Magnetic Resonance Imaging; D060787:Neoplasm Grading; D009362:Neoplasm Metastasis; D009367:Neoplasm Staging; D009369:Neoplasms; D010043:Outcome and Process Assessment, Health Care; D010342:Patient Acceptance of Health Care; D016217:Ultrasonography, Mammary