title: Silodosin : a new subtype selective alpha-1 antagonist for the treatment of lower urinary tract symptoms in patients with benign prostatic hyperplasia.
abstract: BACKGROUND
  Silodosin is a new uroselective alpha-blocker with high pharmacological selectivity for the (1A) adrenoceptor. It is an effective and well-tolerated treatment in men with lower urinary tract symptoms (LUTS), due to presumed bladder outlet obstruction secondary to benign prostatic hyperplasia (BPH). The efficacy of silodosin is at least equivalent to existing selective alpha-1 antagonists such as tamsulosin. A beneficial consequence of its high selectivity is improved cardiovascular safety and failure to interact with other therapies such as anti-hypertensives and phosphodiesterase type-5 inhibitors.
  
  
  METHODS
  This paper discusses the mechanism of action, uroselectivity and clinical efficacy/tolerability of Silodosin. Additionally, drug interactions and urodynamic effects are reviewed with a focus on ejaculatory dysfunction.
  
  
  CONCLUSIONS
  Silodosin is a rapidly efficacious and safe agent in the treatment of LUTS/BPH in men. A lack of clinically important cardiovascular side effects makes it of potential use in the elderly. There is a higher risk of ejaculatory dysfunction, which may lead to discontinuation in younger men. The availability of generic counterparts may make this compound less marketable in countries with social healthcare systems.
authors.affiliation: The Royal Hallamshire Hospital, Sheffield Teaching Hospitals NHS Foundation Trust, Department of Urology, Glossop Road, Sheffield S10 2JF, UK.
authors.forename: Nadir I
authors.initials: NI
authors.lastname: Osman
authors.forename: Christopher R
authors.initials: CR
authors.lastname: Chapple
authors.forename: Francisco
authors.initials: F
authors.lastname: Cruz
authors.forename: François
authors.initials: F
authors.lastname: Desgrandchamps
authors.forename: Carlos
authors.initials: C
authors.lastname: Llorente
authors.forename: Francesco
authors.initials: F
authors.lastname: Montorsi
mesh_terms: D058668:Adrenergic alpha-1 Receptor Antagonists / Q000494:pharmacology / Q000627:therapeutic use*; D004347:Drug Interactions; D006801:Humans; D007211:Indoles / Q000494:pharmacology / Q000627:therapeutic use*; D059411:Lower Urinary Tract Symptoms / Q000188:drug therapy* / Q000209:etiology; D008297:Male; D060735:Pharmacovigilance; D011470:Prostatic Hyperplasia / Q000150:complications / Q000188:drug therapy*; D018340:Receptors, Adrenergic, alpha-1
chemical_list: D058668:Adrenergic alpha-1 Receptor Antagonists; D007211:Indoles; D018340:Receptors, Adrenergic, alpha-1; C095285:silodosin