title: Icatibant and ACE inhibitor angioedema.
abstract: Icatibant is a selective bradykinin 2 receptor antagonist, currently licensed for use in hereditary angioedema. Its benefit in ACE inhibitor angioedema is yet to be fully established. A handful of preliminary case reports suggest that it may be of benefit in reducing both symptom severity and possible hospital or intensive care admission. To date, there are no case reports of the usage of Icatibant in the emergency department in the UK. Here we report our experience of Icatibant in a 62-year-old gentleman presenting with severe oral, pharyngeal and laryngeal oedema while on an ACE inhibitor.
authors.affiliation: Department of ENT, Warrington General Hospital, Warrington, UK. Elizabethilling@doctors.org.uk
authors.forename: Elizabeth Janet
authors.initials: EJ
authors.lastname: Illing
authors.forename: Sara
authors.initials: S
authors.lastname: Kelly
authors.forename: Jonathan Charles
authors.initials: JC
authors.lastname: Hobson
authors.forename: Seema
authors.initials: S
authors.lastname: Charters
mesh_terms: D000319:Adrenergic beta-Antagonists / Q000627:therapeutic use*; D000799:Angioedema / Q000139:chemically induced / Q000188:drug therapy*; D000806:Angiotensin-Converting Enzyme Inhibitors / Q000009:adverse effects; D001920:Bradykinin / Q000031:analogs & derivatives* / Q000627:therapeutic use; D065094:Bradykinin B2 Receptor Antagonists; D004825:Epiglottis; D006801:Humans; D007442:Intubation, Intratracheal; D008297:Male; D008875:Middle Aged; D017257:Ramipril / Q000009:adverse effects; D014059:Tongue; D014827:Vocal Cords
chemical_list: D000319:Adrenergic beta-Antagonists; D000806:Angiotensin-Converting Enzyme Inhibitors; D065094:Bradykinin B2 Receptor Antagonists; C065679:icatibant; D017257:Ramipril; D001920:Bradykinin