title: Adverse drug reaction-related admissions in paediatrics, a prospective single-centre study.
abstract: OBJECTIVE
  To investigate the incidence and characteristics of hospital admissions related to adverse drug events in the paediatric setting.
  
  
  METHODS
  Prospective single-centre study.
  
  
  METHODS
  A secondary and tertiary paediatric care centre.
  
  
  METHODS
  A total of 683 acutely admitted patients, aged 0-18 year. All acutely admitted patients, using medication before admission, were prospectively screened for possible Adverse Drug Reactions (ADR)-related admission with a trigger list. Included cases were analysed with the Naranjo score for the assessment of causality.
  
  
  METHODS
  This research explored the incidence of ADR-related admissions and investigated the relation between ADR and the licensing status of the medicines, as well as the severity and potential to prevent the ADRs.
  
  
  RESULTS
  A total of 683 patients were admitted acutely during the study period, 47 of them were exposed to cancer chemotherapy. Fifteen patients not exposed to chemotherapy (2.4%) were admitted due to an ADR. Five of these 15 ADRs (33%) were caused by unlicensed or off-label used drugs. Thirty-two patients exposed to chemotherapy (68.1%) were admitted due to an ADR; 27 of these (84%) were caused by unlicensed or off-label used drugs.
  
  
  CONCLUSIONS
  In conclusion, this study shows that ADR-related hospital admissions occur more frequently in the paediatric population compared with adults, and more frequently in patients exposed to cancer chemotherapy. No relation was found between the unlicensed and off-label used drugs and the incidence of ADRs.
authors.affiliation: Erasmus MC, Rotterdam, The Netherlands.
authors.forename: Anke A G
authors.initials: AA
authors.lastname: Posthumus
authors.forename: Carien C W
authors.initials: CC
authors.lastname: Alingh
authors.forename: Christian C M
authors.initials: CC
authors.lastname: Zwaan
authors.forename: Kees K
authors.initials: KK
authors.lastname: van Grootheest
authors.forename: Lidwien L M
authors.initials: LL
authors.lastname: Hanff
authors.forename: Bregje B C M
authors.initials: BB
authors.lastname: Witjes
authors.forename: Geert W
authors.initials: GW
authors.lastname: 't Jong
authors.forename: Matthijs
authors.initials: M
authors.lastname: de Hoog