title: A novel surface-enhanced Raman scattering nanosensor for detecting multiple heavy metal ions based on 2-mercaptoisonicotinic acid functionalized gold nanoparticles.
abstract: A novel, effective and simple surface-enhanced Raman scattering (SERS) nanosensor for selectively and sensitively detecting heavy metal ions in aqueous solution has been developed in the form of 2-mercaptoisonicotinic acid (2 MNA)-modified gold nanoparticles (AuNPs). Multiple heavy metal ions can be identified and quantified by using relative peak intensity ratios of selected vibrational bands in the SERS spectra of 2 MNA. Especially, concentration of Hg(2+) and Pb(2+) ions are determined by comparing the intensity ratios of the bands 1160/1230 cm(-1) for Hg(2+) and 861/815 cm(-1) (or 815/1392 cm(-1)) for Pb(2+), with detection limits of 3.4×10(-8) and 1.0×10(-7)M, respectively. 2 MNA-AuNPs sensors show a high selectivity for Hg(2+) without masking reagent, and they can also be highly selective for Pb(2+) when using sodium thiosulphate and l-cysteine as masking reagents. These results demonstrate that these 2 MNA-AuNPs nanosensors are promising candidates for in situ heavy metal ions detection and quantification, maybe even inside living cells.
authors.affiliation: Key Laboratory of Bio-Inspired Smart Interfacial Science and Technology of Ministry of Education, School of Chemistry and Environment, Beihang University, Beijing 100191, PR China.
authors.forename: Enzhong
authors.initials: E
authors.lastname: Tan
authors.forename: Penggang
authors.initials: P
authors.lastname: Yin
authors.forename: Xiufeng
authors.initials: X
authors.lastname: Lang
authors.forename: Hongyan
authors.initials: H
authors.lastname: Zhang
authors.forename: Lin
authors.initials: L
authors.lastname: Guo
mesh_terms: D006046:Gold / Q000737:chemistry*; D007477:Ions; D007539:Isonicotinic Acids / Q000737:chemistry*; D007854:Lead / Q000032:analysis; D008628:Mercury / Q000032:analysis; D053768:Metal Nanoparticles / Q000737:chemistry* / Q000648:ultrastructure; D019216:Metals, Heavy / Q000032:analysis*; D036103:Nanotechnology / Q000295:instrumentation* / Q000379:methods*; D013059:Spectrum Analysis, Raman; D013499:Surface Properties; D013997:Time Factors; D014867:Water / Q000737:chemistry
chemical_list: D007477:Ions; D007539:Isonicotinic Acids; D019216:Metals, Heavy; D014867:Water; D007854:Lead; D006046:Gold; D008628:Mercury