title: Determination of L-tryptophan based on graphene oxide-magnetite-molecularly imprinted polymers and chemiluminescence.
abstract: A new method for determination of L-tryptophan (L-try) using the flow injection chemiluminescence (FI-CL) system of KMnO(4)-SnCl(2)-CHOH based on a graphene oxide-magnetite-molecularly imprinted polymer (GM-MIP) is described. The L-try GM-MIP was synthesized using graphene oxide (G) which improved the adsorption capacity as carrier, and magnetite nanoparticles which made the polymers easier to use in the sensor. The adsorption performance and properties were characterized. The GM-MIP was used in CL analysis to increase the selectivity and the possible mechanism was also discussed. The CL sensor responded linearly to the concentration of L-try over the range from 2.10×10(-7) to 7.09×10(-4) M with a detection limit of 2.11×10(-8) M (3σ). The relative standard deviation (RSD) for the determination of 3.0×10(-5) M L-try was 2.40% (n=11). On the basis of speediness and sensitivity, the sensor is reusable and shows a great improvement in selectivity and adsorption capacity over other sensors. The sensor has been used for the determination of L-try in drug samples.
authors.affiliation: Key Laboratory of Chemical Sensing & Analysis in Universities of Shandong (University of Jinan), School of Chemistry and Chemical Engineering, University of Jinan, Jinan 250022, China.
authors.forename: Huamin
authors.initials: H
authors.lastname: Qiu
authors.forename: Chuannan
authors.initials: C
authors.lastname: Luo
authors.forename: Min
authors.initials: M
authors.lastname: Sun
authors.forename: Fuguang
authors.initials: F
authors.lastname: Lu
authors.forename: Lulu
authors.initials: L
authors.lastname: Fan
authors.forename: Xiangjun
authors.initials: X
authors.lastname: Li
mesh_terms: D000327:Adsorption; D052203:Ferrosoferric Oxide / Q000737:chemistry*; D017022:Flow Injection Analysis; D006108:Graphite / Q000737:chemistry*; D006801:Humans; D057230:Limit of Detection; D049449:Luminescence; D008163:Luminescent Measurements; D054802:Molecular Imprinting; D010087:Oxides; D011108:Polymers / Q000737:chemistry*; D011196:Potassium Permanganate / Q000737:chemistry; D055553:Prescription Drugs / Q000737:chemistry*; D017971:Tin Compounds / Q000737:chemistry; D014364:Tryptophan / Q000032:analysis*
chemical_list: D010087:Oxides; D011108:Polymers; D055553:Prescription Drugs; D017971:Tin Compounds; D011196:Potassium Permanganate; C023599:stannous chloride; D006108:Graphite; D014364:Tryptophan; D052203:Ferrosoferric Oxide