title: Complete genome sequence of two coxsackievirus A1 strains that were cytotoxic to human rhabdomyosarcoma cells.
abstract: Coxsackievirus A1 (CVA1) belongs to human enterovirus species C within the family Picornaviridae, order Picornavirales. Two Chinese CVA1 isolates, HT-THLH02F/XJ/CHN/2011 and KS-ZPH01F/XJ/CHN/2011, were isolated from stool specimens of two healthy children in the Xinjiang Uygur autonomous region of China. They were found to elicit cytopathic effects in a human rhabdomyosarcoma cell line, and complete genome sequences of these two CVA1 isolates revealed that natural intertypic recombination events occurred between CVA1 and CVA22.
authors.affiliation: WHO WPRO Regional Polio Reference Laboratory, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, People's Republic of China.
authors.forename: Qiang
authors.initials: Q
authors.lastname: Sun
authors.forename: Yong
authors.initials: Y
authors.lastname: Zhang
authors.forename: Shuangli
authors.initials: S
authors.lastname: Zhu
authors.forename: Hui
authors.initials: H
authors.lastname: Cui
authors.forename: Huifang
authors.initials: H
authors.lastname: Tian
authors.forename: Dongmei
authors.initials: D
authors.lastname: Yan
authors.forename: Guohong
authors.initials: G
authors.lastname: Huang
authors.forename: Zhen
authors.initials: Z
authors.lastname: Zhu
authors.forename: Dongyan
authors.initials: D
authors.lastname: Wang
authors.forename: Xiaolei
authors.initials: X
authors.lastname: Li
authors.forename: Huafang
authors.initials: H
authors.lastname: Jiang
authors.forename: Hongqiu
authors.initials: H
authors.lastname: An
authors.forename: Wenbo
authors.initials: W
authors.lastname: Xu
mesh_terms: D045744:Cell Line, Tumor; D002648:Child; D002681:China; D003588:Cytopathogenic Effect, Viral; D030015:Enterovirus C, Human / Q000145:classification / Q000235:genetics* / Q000302:isolation & purification / Q000472:pathogenicity; D016679:Genome, Viral; D006801:Humans; D008969:Molecular Sequence Data; D010802:Phylogeny; D011995:Recombination, Genetic; D012208:Rhabdomyosarcoma