title: Comparison of 12-hour urine protein and protein:creatinine ratio with 24-hour urine protein for the diagnosis of preeclampsia.
abstract: OBJECTIVE
  The purpose of this study was to evaluate the performance of the 12-hour urine protein >165 mg and protein:creatinine ratio >0.15 for the prediction of 24-hour urine protein of ≥300 mg in patients with suspected preeclampsia.
  
  
  METHODS
  We performed a prospective observational study of 90 women who had been admitted with suspected preeclampsia. Protein:creatinine ratio and 12- and 24-hour urine specimens were collected for each patient. Test characteristics for the identification of 24-hour urine protein ≥300 mg were calculated.
  
  
  RESULTS
  A 12-hour urine protein >165 mg and protein:creatinine ratio of >0.15 correlated significantly with 24-hour urine protein ≥300 mg (r = 0.99; P < .001; and r = 0.54; P < .001, respectively). A 12-hour urine protein >165 mg performed better than protein:creatinine ratio as a predictor of a 24-hour urine protein ≥300 mg (sensitivity, 96% and 89%; specificity, 100% and 49%; positive predictive value, 100% and 32%; negative predictive value, 98% and 91%, respectively).
  
  
  CONCLUSIONS
  The high correlation of a 12-hour urine protein >165 mg with a 24-hour urine protein ≥300 mg (with the benefit of a shorter evaluation time) and the high negative predictive value of protein:creatinine ratio suggest that the use of both these tests have a role in the evaluation and treatment of women with suspected preeclampsia.
authors.affiliation: Department of Obstetrics and Gynecology, Lehigh Valley Health Network, Allentown, PA.
authors.forename: Christina
authors.initials: C
authors.lastname: Tun
authors.forename: Joanne N
authors.initials: JN
authors.lastname: Quiñones
authors.forename: Anita
authors.initials: A
authors.lastname: Kurt
authors.forename: John C
authors.initials: JC
authors.lastname: Smulian
authors.forename: Meredith
authors.initials: M
authors.lastname: Rochon
mesh_terms: D000293:Adolescent; D000328:Adult; D003404:Creatinine / Q000652:urine*; D005260:Female; D006801:Humans; D008875:Middle Aged; D011225:Pre-Eclampsia / Q000175:diagnosis* / Q000652:urine*; D011247:Pregnancy; D011446:Prospective Studies; D011507:Proteinuria / Q000652:urine*; D013997:Time Factors; D055815:Young Adult
chemical_list: D003404:Creatinine