title: Synthesis and characterization of highly water-soluble dendrofulleropyrrolidine bisadducts with DNA binding activity.
abstract: The synthesis, characterization and DNA binding studies of a series of polycationic fullerene adducts are reported. These cationic species, exhibiting reasonably high water solubility and a heterogeneous distribution of positive charges, can efficiently complex plasmid DNA. Electrophoresis studies show different DNA binding efficiencies for different adducts, some of which can be considered excellent candidates for DNA binding therapies.
authors.affiliation: Center of Excellence for Nanostructured Materials (CENMAT), Department of Chemical and Pharmaceutical Sciences, and INSTM, unit of Trieste, University of Trieste, Piazzale Europa 1, 34127 Trieste, Italy.
authors.forename: Alejandro Montellano
authors.initials: AM
authors.lastname: López
authors.forename: Francesco
authors.initials: F
authors.lastname: Scarel
authors.forename: Noelia Rubio
authors.initials: NR
authors.lastname: Carrero
authors.forename: Ester
authors.initials: E
authors.lastname: Vázquez
authors.forename: Aurelio
authors.initials: A
authors.lastname: Mateo-Alonso
authors.forename: Tatiana
authors.initials: T
authors.lastname: Da Ros
authors.forename: Maurizio
authors.initials: M
authors.lastname: Prato
mesh_terms: D004247:DNA / Q000737:chemistry*; D037741:Fullerenes / Q000737:chemistry*; D015394:Molecular Structure; D011759:Pyrrolidines / Q000138:chemical synthesis* / Q000737:chemistry; D012995:Solubility; D014867:Water / Q000737:chemistry
chemical_list: D037741:Fullerenes; D011759:Pyrrolidines; D014867:Water; D004247:DNA