title: Development of a multicomponent Staphylococcus aureus vaccine designed to counter multiple bacterial virulence factors.
abstract: Staphylococcus aureus is a major cause of healthcare-associated infections and is responsible for a substantial burden of disease in hospitalized patients. Despite increasingly rigorous infection control guidelines, the prevalence and corresponding negative impact of S. aureus infections remain considerable. Difficulties in controlling S. aureus infections as well as the associated treatment costs are exacerbated by increasing rates of resistance to available antibiotics. Despite ongoing efforts over the past 20 years, no licensed S. aureus vaccine is currently available. However, learning from past clinical failures of vaccine candidates and a better understanding of the immunopathology of S. aureus colonization and infection have aided in the design of new vaccine candidates based on multiple important bacterial pathogenesis mechanisms. This review outlines important considerations in designing a vaccine for the prevention of S. aureus disease in healthcare settings.
authors.affiliation: Pfizer Vaccine Research; Pearl River, NY USA.
authors.forename: Annaliesa S
authors.initials: AS
authors.lastname: Anderson
authors.forename: Alita A
authors.initials: AA
authors.lastname: Miller
authors.forename: Robert G K
authors.initials: RG
authors.lastname: Donald
authors.forename: Ingrid L
authors.initials: IL
authors.lastname: Scully
authors.forename: Jasdeep S
authors.initials: JS
authors.lastname: Nanra
authors.forename: David
authors.initials: D
authors.lastname: Cooper
authors.forename: Kathrin U
authors.initials: KU
authors.lastname: Jansen
mesh_terms: D000818:Animals; D001428:Bacterial Vaccines / Q000276:immunology* / Q000627:therapeutic use*; D006801:Humans; D013203:Staphylococcal Infections / Q000276:immunology* / Q000517:prevention & control*; D013211:Staphylococcus aureus / Q000276:immunology* / Q000472:pathogenicity*; D037521:Virulence Factors / Q000276:immunology*
chemical_list: D001428:Bacterial Vaccines; D037521:Virulence Factors