title: Skin rejuvenation by microneedle fractional radiofrequency treatment in Asian skin; clinical and histological analysis.
abstract: BACKGROUND
  For skin rejuvenation, microneedle fractional radiofrequency (RF) is a recently developed minimally invasive method for delivering RF energy directly into the skin using microneedle.
  
  
  OBJECTIVE
  We evaluated efficacy and safety of microneedle fractional RF for skin rejuvenation in Asian skin and also conducted immunohistochemical analysis before and after treatment.
  
  
  METHODS
  Twenty-five females (mean age 54.2, Fitzpatrick skin phototypes III-IV) received three consecutive fractional RF treatment at 4-week intervals. Outcome assessments included standardized photography, physician's global assessment, patient's satisfaction scores, objective biophysical measurements, and histologic analysis including immunohistochemical staining.
  
  
  RESULTS
  All patients showed clinical improvement on physician's global assessment and patient's satisfaction scores. Among objective biophysical measurements, improvement in hydration and skin roughness was noticed. Histologic examination revealed marked increase in dermal thickness, dermal collagen content and dermal fibrillin content. Side effects were minimal.
  
  
  CONCLUSIONS
  The limitations are the small number of patients and lack of long-term follow-up.
  
  
  CONCLUSIONS
  Microneedle fractional RF is a safe and effective skin rejuvenation method in Asians.
authors.affiliation: Department of Dermatology, CHA Bundang Medical Center, CHA University, Republic of Korea.
authors.forename: Kyu Young
authors.initials: KY
authors.lastname: Seo
authors.forename: Moon Soo
authors.initials: MS
authors.lastname: Yoon
authors.forename: Dong Hyun
authors.initials: DH
authors.lastname: Kim
authors.forename: Hee Jung
authors.initials: HJ
authors.lastname: Lee
mesh_terms: D000328:Adult; D044466:Asian People; D001834:Body Water / Q000378:metabolism; D024042:Collagen Type I / Q000378:metabolism; D020405:Dermis / Q000378:metabolism; D019583:Dose Fractionation, Radiation; D005260:Female; D000071837:Fibrillins; D006801:Humans; D007150:Immunohistochemistry; D008840:Microfilament Proteins / Q000378:metabolism; D008875:Middle Aged; D017060:Patient Satisfaction; D011446:Prospective Studies; D000078702:Radiofrequency Therapy; D012060:Rejuvenation; D012867:Skin / Q000378:metabolism / Q000473:pathology / Q000528:radiation effects*; D015595:Skin Aging / Q000528:radiation effects*
chemical_list: D024042:Collagen Type I; D000071837:Fibrillins; D008840:Microfilament Proteins