title: The faltering solid organ donor pool in the United States (2001-2010).
abstract: BACKGROUND
  Organ shortage is the greatest challenge facing the field of organ transplantation today. Use of more organs of marginal quality has been advocated to address the shortage.
  
  
  METHODS
  We examined the pattern of donation and organ use in the United States as shown in the Organ Procurement and Transplantation Network/United Network for Organ Sharing database of individuals who were consented for and progressed to organ donation between January 2001 and December 2010.
  
  
  RESULTS
  There were 66,421 living donors and 73,359 deceased donors, including 67,583 (92.1%) identified as donation after brain death and 5,776 (7.9%) as donation after circulatory death (DCD). Comparing two periods, era 1 (01/2001-12/2005) and era 2 (01/2006-12/2010), the number of deceased donors increased by 20.3% from 33,300 to 40,059 while there was a trend for decreasing living donation. The DCD subgroup increased from 4.9 to 11.7% comparing the two eras. A significant increase in cardiovascular/cerebrovascular disease as a cause of death was also noted, from 38.1% in era 1 to 56.1% in era 2 (p<0.001), as was a corresponding decrease in the number of deaths due to head trauma (48.8 vs. 34.9%). The overall discard rate also increased from 13,411 (11.5%) in era 1 to 19,516 (13.7%) in era 2. This increase in discards was especially prominent in the DCD group [440 (20.9%) in era 1 vs. 2,089 (24.9%) in era 2].
  
  
  CONCLUSIONS
  We detect a significant change in pattern of organ donation and use in the last decade in the United States. The transplant community should consider every precaution to prevent the decay of organ quality and to improve the use of marginal organs.
authors.affiliation: Division of Organ Transplantation, Department of Surgery, University of Massachusetts Medical School, 55 Lake Avenue North, S6-426, Worcester, MA 01655, USA. Reza.Saidi@umassmemorial.org
authors.forename: Reza F
authors.initials: RF
authors.lastname: Saidi
authors.forename: James F
authors.initials: JF
authors.lastname: Markmann
authors.forename: Nicolas
authors.initials: N
authors.lastname: Jabbour
authors.forename: YouFu
authors.initials: Y
authors.lastname: Li
authors.forename: Shimul A
authors.initials: SA
authors.lastname: Shah
authors.forename: A B
authors.initials: AB
authors.lastname: Cosimi
authors.forename: Adel
authors.initials: A
authors.lastname: Bozorgzadeh
mesh_terms: D002423:Cause of Death; D016208:Databases, Factual; D046148:Donor Selection / Q000706:statistics & numerical data / Q000639:trends; D006801:Humans; D019520:Living Donors / Q000706:statistics & numerical data; D014019:Tissue Donors / Q000706:statistics & numerical data*; D009927:Tissue and Organ Procurement / Q000379:methods / Q000706:statistics & numerical data* / Q000639:trends; D014481:United States