title: Evidence that in vitro susceptibility of CD3+ T lymphocytes to equine arteritis virus infection reflects genetic predisposition of naturally infected stallions to become carriers of the virus.
abstract: We investigated the correlation between in vitro susceptibility of CD3(+) T lymphocytes to equine arteritis virus (EAV) infection and establishment of persistent infection among 14 stallions following natural infections. The data showed that carrier stallions with a CD3(+) T lymphocyte susceptibility phenotype to in vitro EAV infection may be at higher risk of becoming carriers than those that lack this phenotype (P = 0.0002).
authors.affiliation: Maxwell H. Gluck Equine Research Center, Department of Veterinary Science, University of Kentucky, Lexington, Kentucky, USA.
authors.forename: Yun Young
authors.initials: YY
authors.lastname: Go
authors.forename: Ernest
authors.initials: E
authors.lastname: Bailey
authors.forename: Peter J
authors.initials: PJ
authors.lastname: Timoney
authors.forename: Kathleen M
authors.initials: KM
authors.lastname: Shuck
authors.forename: Udeni B R
authors.initials: UB
authors.lastname: Balasuriya
mesh_terms: D000818:Animals; D018174:Arterivirus Infections / Q000378:metabolism / Q000635:transmission / Q000821:virology*; D017252:CD3 Complex / Q000096:biosynthesis*; D002353:Carrier State / Q000662:veterinary; D007240:Equartevirus / Q000378:metabolism*; D020022:Genetic Predisposition to Disease; D006239:Haplotypes; D006734:Horse Diseases / Q000821:virology*; D006736:Horses; D066298:In Vitro Techniques; D008297:Male; D008856:Microscopy, Fluorescence / Q000379:methods; D010641:Phenotype; D012306:Risk; D013601:T-Lymphocytes / Q000821:virology*
chemical_list: D017252:CD3 Complex