title: Design, synthesis, and in vitro antitumor evaluation of novel phenylaminopyrimidine derivatives.
abstract: Two series of novel phenylaminopyrimidine derivatives were designed and synthesized. All target compounds were determined against the human acute monocytic leukemia cell line U937 and the human chronic myeloid leukemia cell line K562 in vitro. Some of the target compounds demonstrated significant inhibitory activity against both cell lines. Compared with the control drug VX-680, 8a, 8e, 8g, 8h, 8j, and 8k demonstrated more potent antitumor activity. The structures of all target compounds were identified by 1H-NMR, 13C-NMR, IR, MS, and EA.
authors.affiliation: College of Pharmacy, Xuzhou Medical College, Xuzhou, China. zhengyouguang@yahoo.com.cn
authors.forename: Youguang
authors.initials: Y
authors.lastname: Zheng
authors.forename: Ming
authors.initials: M
authors.lastname: Zheng
authors.forename: Yi
authors.initials: Y
authors.lastname: Liu
authors.forename: Yunsheng
authors.initials: Y
authors.lastname: Xue
authors.forename: Ling
authors.initials: L
authors.lastname: Zhang
authors.forename: Lin
authors.initials: L
authors.lastname: An
authors.forename: Ling
authors.initials: L
authors.lastname: Liu
authors.forename: Min
authors.initials: M
authors.lastname: Ji
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D049109:Cell Proliferation / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D015195:Drug Design; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D020128:Inhibitory Concentration 50; D020014:K562 Cells; D010879:Piperazines / Q000737:chemistry / Q000494:pharmacology; D011743:Pyrimidines / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D020298:U937 Cells; D003521:Cyclopropanes; D011720:Pyrazoles
chemical_list: D000970:Antineoplastic Agents; D010879:Piperazines; D011743:Pyrimidines; C484810:tozasertib; D003521:Cyclopropanes; D011720:Pyrazoles