title: The effects of Ang-1, IL-8 and TGF-β1 on the pathogenesis of COPD.
abstract: Chronic obstructive pulmonary disease (COPD) is a prevalent smoking-related             disease for which no disease‑altering therapies currently exist. Airway remodeling             is one of the most important mechanisms in the pathogenesis of COPD and is triggered             by chronic inflammation mediated by angiopoietin-1 (Ang-1), interleukin-8 (IL-8)             and transforming growth factor-β1 (TGF-β1). The aim of this study was to investigate             the effects of Ang-1, IL-8 and TGF-β1 on the pathogenesis of COPD. Forty-two COPD             patients and 10 healthy adults (group A) were included in this study. We divided             the 42 patients into 4 groups (groups B-E) according to the severity of the disease.             We investigated the levels of Ang-1, IL-8 and TGF-β1 and the levels of pulmonary             function (PF) in the stable and acute phases of COPD by enzyme-linked immunosorbent             assay. We found statistically significant differences in the expression levels             of Ang-1, IL-8 and TGF-β1 between the stable and acute phases in groups B-E. We             found statistically significant differences in the expression levels of Ang-1             among all groups in the stable phase. In addition, there were statistically significant             differences in the expression levels of TGF-β1 among all groups. There were statistically             significant differences in the expression levels of IL-8 between group A and the             other groups in the stable phase. Furthermore, in groups C-E we found higher correlations             between Ang-1 and the forced expiratory volume in one second of forced vital capacity             (FVC) [FEV1(%)] and FEV1/FVC(%) than between TGF-β1 and FEV1(%) and FEV1/FVC(%).             We conclude that the blood vessel factor is more closely related to the pathogenesis             of COPD.
authors.affiliation: Department of Respiratory Medicine, Jiaozhou Central Hospital, Qingdao, Shandong, PR China.
authors.forename: Jixu
authors.initials: J
authors.lastname: Gao
authors.forename: Bingyan
authors.initials: B
authors.lastname: Zhan
mesh_terms: D000208:Acute Disease; D042683:Angiopoietin-1 / Q000378:metabolism*; D005541:Forced Expiratory Volume / Q000502:physiology; D006801:Humans; D016209:Interleukin-8 / Q000378:metabolism*; D008297:Male; D029424:Pulmonary Disease, Chronic Obstructive / Q000378:metabolism* / Q000503:physiopathology; D012720:Severity of Illness Index; D053773:Transforming Growth Factor beta1 / Q000378:metabolism*; D014797:Vital Capacity / Q000502:physiology
chemical_list: D042683:Angiopoietin-1; D016209:Interleukin-8; D053773:Transforming Growth Factor beta1