title: Diverse mechanisms of antidiabetic effects of the different procyanidin oligomer types of two different cinnamon species on db/db mice.
abstract: The procyanidin oligomers are thought to be responsible for the antidiabetic activity of cinnamon. To investigate the hypoglycemic effects of different procyanidin oligomer types, the procyanidin oligomer-rich extracts were prepared from two different cinnamon species. Using high-performance liquid chromatography with purified procyanidin oligomers as reference compounds, we found that the  Cinnamomum cassia  extract (CC-E) and  Cinnamomum tamala  extract (CT-E) were rich in B- and A-type procyanidin oligomers, respectively. In the experiment, 8-week-old diabetic (db/db) mice were gavaged with CC-E and CT-E (both 200 mg/kg per day) for 4 weeks. Both CC-E and CT-E exhibited antidiabetic effects. Moreover, histopathological studies of the pancreas, liver, and adipose tissue showed that CC-E promoted lipid accumulation in the adipose tissue and liver, whereas CT-E mainly improved the insulin concentration in the blood and pancreas.
authors.affiliation: School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, People's Republic of China.
authors.forename: Liang
authors.initials: L
authors.lastname: Chen
authors.forename: Peng
authors.initials: P
authors.lastname: Sun
authors.forename: Ting
authors.initials: T
authors.lastname: Wang
authors.forename: Kaixian
authors.initials: K
authors.lastname: Chen
authors.forename: Qi
authors.initials: Q
authors.lastname: Jia
authors.forename: Heyao
authors.initials: H
authors.lastname: Wang
authors.forename: Yiming
authors.initials: Y
authors.lastname: Li
mesh_terms: D000818:Animals; D044946:Biflavonoids / Q000008:administration & dosage*; D001786:Blood Glucose / Q000378:metabolism; D002392:Catechin / Q000008:administration & dosage*; D002935:Cinnamomum zeylanicum / Q000737:chemistry*; D003924:Diabetes Mellitus, Type 2 / Q000188:drug therapy* / Q000378:metabolism; D004195:Disease Models, Animal; D005260:Female; D006801:Humans; D007004:Hypoglycemic Agents / Q000008:administration & dosage*; D008297:Male; D051379:Mice; D008517:Phytotherapy; D010936:Plant Extracts / Q000008:administration & dosage*; D044945:Proanthocyanidins / Q000008:administration & dosage*
chemical_list: D044946:Biflavonoids; D001786:Blood Glucose; D007004:Hypoglycemic Agents; D010936:Plant Extracts; D044945:Proanthocyanidins; C017674:procyanidin; D002392:Catechin