title: Tomographic imaging of the spleen: the role of morphological and metabolic features in differentiating benign from malignant diseases.
abstract: To evaluate the tomographic features in differentiating benign from malignant splenic diseases, 54 patients with a cytohistological examination and a contrast-enhanced multidetector computed tomography (ce-MDCT) and/or positron emission tomography/computed tomography (PET/CT) were retrospectively selected. Significant associations were observed between ce-MDCT Pattern 3 (focal hyperdense lesion) and Pattern 4 (infarcts/cysts) as well as PET/CT Pattern 3 (focal photopenia/diffuse uptake<liver) and benign pathologies, and between ce-MDCT Pattern 1 (splenomegaly without focal lesions) and Pattern 2 (focal hypodense lesion) as well as PET/CT Pattern 1 (diffuse uptake ≥ liver) and Pattern 2 (focal increased uptake) and malignant diseases. No significant association between benign or malignant diseases and spleen volumes and maximum standardized uptake value (SUV(max)) as well as lesion characteristics was observed. The metabolic data do not improve the performance of morphological patterns.
authors.affiliation: IBB CNR, Napoli, Via Pansini 5, 80131 Naples, Italy. pierpamainenti@hotmail.com
authors.forename: Pier Paolo
authors.initials: PP
authors.lastname: Mainenti
authors.forename: Delfina
authors.initials: D
authors.lastname: Iodice
authors.forename: Immacolata
authors.initials: I
authors.lastname: Cozzolino
authors.forename: Sabrina
authors.initials: S
authors.lastname: Segreto
authors.forename: Sergio
authors.initials: S
authors.lastname: Capece
authors.forename: Giacomo
authors.initials: G
authors.lastname: Sica
authors.forename: Mario
authors.initials: M
authors.lastname: Magliulo
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Ciancia
authors.forename: Leonardo
authors.initials: L
authors.lastname: Pace
authors.forename: Marco
authors.initials: M
authors.lastname: Salvatore
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D003287:Contrast Media; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D007472:Iohexol / Q000031:analogs & derivatives; D008297:Male; D008875:Middle Aged; D064847:Multimodal Imaging / Q000379:methods*; D049268:Positron-Emission Tomography; D011857:Radiographic Image Interpretation, Computer-Assisted; D012189:Retrospective Studies; D013158:Splenic Diseases / Q000000981:diagnostic imaging* / Q000473:pathology; D014057:Tomography, X-Ray Computed / Q000379:methods*
chemical_list: D003287:Contrast Media; D007472:Iohexol; C038192:iopromide