title: Diffuse optical spectroscopy evaluation of treatment response in women with locally advanced breast cancer receiving neoadjuvant chemotherapy.
abstract: The aim of this study was to investigate the potential of diffuse optical spectroscopy for monitoring of patients with locally advanced breast cancer (LABC) undergoing neoadjuvant chemotherapy. Fifteen women receiving treatment for LABC had the affected breast scanned before; 1 week, 4 weeks, and 8 weeks after treatment initiation; and before surgery. Optical properties related to tissue microstructure and biochemical composition were obtained. Clinical and pathologic tumor response was evaluated using whole-mount pathology after mastectomy. Patients who responded to treatment demonstrated an initial increase followed by a drop in optical parameters measured in the whole breast, whereas nonresponding patients demonstrated only a drop in the same parameters 1 week after treatment initiation. Responding patients demonstrated a significant increase of 17% ± 7%, 8% ± 8%, 10% ± 7%, 11% ± 11%, and 16% ± 15% in deoxygenated hemoglobin, oxygenated hemoglobin, total hemoglobin concentrations, water percentage, and tissue optical index, 1 week after treatment initiation, respectively. In contrast, nonresponding patients had a decrease of 14% ± 9%, 18% ± 7%, 17% ± 7%, 29% ± 7%, and 32% ± 9% in their corresponding optical parameters. Deoxygenated hemoglobin concentration (with 100% sensitivity, 83% specificity) and water percentage (with 75% sensitivity, 100% specificity) were found to be the best predictors of treatment response at 1 week after starting treatment. The results of this study suggest that optical parameters can be potentially used to predict and monitor patients' responses to neoadjuvant chemotherapy and can form a basis for the customization of treatments in which inefficacious treatments can be switched to more efficacious therapies.
authors.affiliation: Department of Radiation Oncology, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada.
authors.forename: Omar
authors.initials: O
authors.lastname: Falou
authors.forename: Hany
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authors.lastname: Soliman
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authors.lastname: Sadeghi-Naini
authors.forename: Sara
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authors.lastname: Iradji
authors.forename: Sharon
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authors.lastname: Lemon-Wong
authors.forename: Judit
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authors.forename: Jacqueline
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authors.lastname: Spayne
authors.forename: Rebecca
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authors.forename: Maureen
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authors.forename: Jean Francois
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authors.lastname: Boileau
authors.forename: Frances C
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authors.lastname: Wright
authors.forename: Martin J
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authors.lastname: Yaffe
authors.forename: Gregory J
authors.initials: GJ
authors.lastname: Czarnota