title: Outer-diameter narrowing of the internal carotid and middle cerebral arteries in moyamoya disease detected on 3D constructive interference in steady-state MR image: is arterial constrictive remodeling a major pathogenesis?
abstract: BACKGROUND
  To obtain information on affected vessels in moyamoya disease (MMD), we analyzed the vascular morphological characteristics of MMD using three-dimensional (3D) constructive interference in steady-state (CISS) magnetic resonance imaging (MRI).
  
  
  METHODS
  The population of this 3D-CISS MRI study consisted of 51 patients with MMD: 16 patients with atherosclerotic middle cerebral artery (MCA) stenosis or occlusion, 42 MRI control patients, and 28 control digital subtraction angiography (DSA) patients. We measured the outer diameters of the terminal portion of the internal carotid artery (ICA) and the proximal portion of the MCA (M1 portion). We evaluated the inner diameter as the relative value (%) obtained from magnified DSA images and analyzed these data.
  
  
  RESULTS
  The outer diameters of the ICA and M1 portions were significantly smaller in the MMD group than in the other two groups, while the M1 outer diameter of the atherosclerosis group was not significantly different compared to the control (ICA: MMD, 2.61 ± 0.46 mm vs. control, 4.04 ± 0.50 mm and M1: MMD, 1.92 ± 0.43 mm vs. control, 3.34 ± 0.54 mm vs. atherosclerosis, 3.45 ± 0.56 mm). Furthermore, in MMD patients, the outer diameter was unrelated to the progression of the luminal stenosis grade estimated by DSA.
  
  
  CONCLUSIONS
  This is the first report that the outer diameters of both the ICA and M1 decrease in MMD patients. Our findings suggest that the vascular constrictive changes of the affected arteries are an important phenomenon reflecting MMD pathology.
authors.affiliation: Department of Neurosurgery, School of Medicine, Kumamoto University, Japan.
authors.forename: Yasuyuki
authors.initials: Y
authors.lastname: Kaku
authors.forename: Motohiro
authors.initials: M
authors.lastname: Morioka
authors.forename: Yuki
authors.initials: Y
authors.lastname: Ohmori
authors.forename: Takayuki
authors.initials: T
authors.lastname: Kawano
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Kai
authors.forename: Hirofumi
authors.initials: H
authors.lastname: Fukuoka
authors.forename: Toshinori
authors.initials: T
authors.lastname: Hirai
authors.forename: Yasuyuki
authors.initials: Y
authors.lastname: Yamashita
authors.forename: Jun-ichi
authors.initials: J
authors.lastname: Kuratsu
mesh_terms: D000293:Adolescent; D000328:Adult; D015901:Angiography, Digital Subtraction / Q000379:methods; D002343:Carotid Artery, Internal / Q000000981:diagnostic imaging / Q000473:pathology*; D003251:Constriction, Pathologic / Q000000981:diagnostic imaging / Q000473:pathology*; D003952:Diagnostic Imaging / Q000379:methods; D005260:Female; D006801:Humans; D021621:Imaging, Three-Dimensional; D018810:Magnetic Resonance Angiography / Q000379:methods; D008297:Male; D020768:Middle Cerebral Artery / Q000000981:diagnostic imaging / Q000473:pathology*; D009072:Moyamoya Disease / Q000000981:diagnostic imaging / Q000473:pathology*; D055815:Young Adult