title: Coblation of the canine vocal fold: a histologic study.
abstract: Controlled ablation (coblation) is a radiofrequency bipolar method of tissue ablation, which destroys tissue at very low temperatures. It has been used in a variety of clinical settings and is most frequently used by the otolaryngologist for tonsillectomy. In this study, we have examined the effect of coblation on the canine larynx by applying coblation to the vocal fold and harvesting the larynx on postoperative days (PODs) 0, 4, and 7. Histologic examination was performed with a variety of stains to examine the healing process. Coblation injury demonstrated complete epithelialization by POD 7. No injury to the underlying vocalis muscle was seen. The inflammatory response demonstrates less inflammation than previously reported with CO(2) laser injury. Coblation is a viable method for removal of tissue from the vocal fold resulting in minimal scar formation and a controlled depth of injury. Further studies should be performed to determine clinical utility in the removal of lesions such as respiratory papillomatosis.
authors.affiliation: Department of Otolaryngology, Drexel University College of Medicine, Philadelphia, Pennsylvania 19107, USA. venudivi@yahoo.com
authors.forename: Venu
authors.initials: V
authors.lastname: Divi
authors.forename: Michael
authors.initials: M
authors.lastname: Benninger
authors.forename: Matti
authors.initials: M
authors.lastname: Kiupel
authors.forename: Allison
authors.initials: A
authors.lastname: Dobbie
mesh_terms: D000818:Animals; D001391:Azo Compounds; D015415:Biomarkers / Q000378:metabolism; D017115:Catheter Ablation / Q000009:adverse effects; D004396:Coloring Agents; D004285:Dogs; D004801:Eosine Yellowish-(YS); D007150:Immunohistochemistry; D007249:Inflammation / Q000209:etiology / Q000473:pathology; D007828:Laryngoscopy; D008739:Methyl Green; D062326:Re-Epithelialization; D016622:Silver Staining; D013997:Time Factors; D014827:Vocal Cords / Q000378:metabolism / Q000473:pathology / Q000601:surgery*
chemical_list: D001391:Azo Compounds; D015415:Biomarkers; D004396:Coloring Agents; C017768:trichrome stain; D008739:Methyl Green; D004801:Eosine Yellowish-(YS)