title: Graphene oxide-photosensitizer conjugate as a redox-responsive theranostic agent.
abstract: A nano-sized graphene oxide-photosensitizer conjugate with a redox-responsive cleavable disulfide linker is non-fluorescent and non-phototoxic, even upon light irradiation. It becomes highly fluorescent and phototoxic inside cancer cells, where glutathione is used as an initiator for activating the photosensitizer.
authors.affiliation: Molecular Imaging & Therapy Branch, National Cancer Center, 323 Ilsan-ro, Goyang-si, Gyeonggi-do 410-769, Korea.
authors.forename: Youngnam
authors.initials: Y
authors.lastname: Cho
authors.forename: Yongdoo
authors.initials: Y
authors.lastname: Choi
mesh_terms: D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D004220:Disulfides / Q000737:chemistry; D031541:Fluorescence Resonance Energy Transfer; D005978:Glutathione / Q000378:metabolism; D006108:Graphite / Q000737:chemistry*; D006801:Humans; D008027:Light; D010084:Oxidation-Reduction; D010087:Oxides / Q000737:chemistry; D017319:Photosensitizing Agents / Q000737:chemistry* / Q000633:toxicity
chemical_list: D004220:Disulfides; D010087:Oxides; D017319:Photosensitizing Agents; D006108:Graphite; D005978:Glutathione