title: Bone scan in metabolic bone diseases. Review.
abstract: Metabolic bone disease encompasses a number of disorders that tend to present a generalized involvement of the whole skeleton. The disorders are mostly related to increased bone turnover and increased uptake of radiolabelled diphosphonate. Skeletal uptake of 99mTc-labelled diphosphonate depends primarily upon osteoblastic activity, and to a lesser extent, skeletal vascularity. A bone scan image therefore presents a functional display of total skeletal metabolism and has valuable role to play in the assessment of patients with metabolic bone disorders. However, the bone scan appearances in metabolic bone disease are often non-specific, and their recognition depends on increased tracer uptake throughout the whole skeleton. It is the presence of local lesions, as in metastatic disease, that makes a bone scan appearance obviously abnormal. In the early stages, there will be difficulty in evaluating the bone scans from many patients with metabolic bone disease. However, in the more severe cases scan appearances can be quite striking and virtually diagnostic.
authors.affiliation: Department of Nuclear Medicine Medical University of Bialystok, Poland.
authors.forename: Saeid
authors.initials: S
authors.lastname: Abdelrazek
authors.forename: Piotr
authors.initials: P
authors.lastname: Szumowski
authors.forename: Franciszek
authors.initials: F
authors.lastname: Rogowski
authors.forename: Agnieszka
authors.initials: A
authors.lastname: Kociura-Sawicka
authors.forename: Małgorzata
authors.initials: M
authors.lastname: Mojsak
authors.forename: Małgorzata
authors.initials: M
authors.lastname: Szorc
mesh_terms: D001851:Bone Diseases, Metabolic / Q000000981:diagnostic imaging*; D001842:Bone and Bones / Q000000981:diagnostic imaging*; D004164:Diphosphonates; D006801:Humans; D011877:Radionuclide Imaging / Q000379:methods*; D017556:Technetium Compounds
chemical_list: D004164:Diphosphonates; D017556:Technetium Compounds; C029045:technetium Tc 99m diphosphonate