title: Carbon dot-based inorganic-organic nanosystem for two-photon imaging and biosensing of pH variation in living cells and tissues.
abstract: A carbon dot (C-Dot)-based two-photon fluorescent probe has been developed for the monitoring of pH changes across a broad range with high sensitivity and selectivity. The inorganic-organic probe also shows good biocompatibility and cell permeability, and thus can be successfully applied in bioimaging and biosensing of physiological pH in living cells, as well as living tissues at a depth of 65-185 μm.
authors.affiliation: Department of Chemistry, Tongji University, Siping Road 1239, Shanghai 200092, P. R. China.
authors.forename: Biao
authors.initials: B
authors.lastname: Kong
authors.forename: Anwei
authors.initials: A
authors.lastname: Zhu
authors.forename: Changqin
authors.initials: C
authors.lastname: Ding
authors.forename: Xiaoming
authors.initials: X
authors.lastname: Zhao
authors.forename: Bo
authors.initials: B
authors.lastname: Li
authors.forename: Yang
authors.initials: Y
authors.lastname: Tian
mesh_terms: D000818:Animals; D015374:Biosensing Techniques; D002244:Carbon / Q000737:chemistry*; D045744:Cell Line, Tumor; D005456:Fluorescent Dyes / Q000737:chemistry; D006801:Humans; D006863:Hydrogen-Ion Concentration; D051379:Mice; D008819:Mice, Nude; D018613:Microscopy, Confocal; D049329:Nanostructures / Q000737:chemistry; D009369:Neoplasms / Q000473:pathology; D017785:Photons; D014183:Transplantation, Heterologous
chemical_list: D005456:Fluorescent Dyes; D002244:Carbon