title: Innate immune recognition of breast tumor cells mediates CCL22 secretion favoring Treg recruitment within tumor environment.
abstract: Regulatory T cells (Treg) have been reported of poor prognosis for overall survival in primary breast tumors (BT). As CCL22 plays a major role in Treg recruitment within primary BT we deciphered the mechanisms involved in the CCL22 production by breast epithelial tumor cells and propose herein the major role of their innate immune recognition in this production.
authors.affiliation: Université de Lyon; Lyon, France ; Université Lyon 1; ISPB; Lyon, France ; Team 11; CRCL INSERM U-1052/CNRS 5286; Lyon, France ; LabEx DEVweCAN; Centre Léon Bérard; Lyon, France ; Centre Léon Bérard; Lyon, France.
authors.forename: Christine
authors.initials: C
authors.lastname: Ménétrier-Caux
authors.forename: Julien
authors.initials: J
authors.lastname: Faget
authors.forename: Cathy
authors.initials: C
authors.lastname: Biota
authors.forename: Michael
authors.initials: M
authors.lastname: Gobert
authors.forename: Jean-Yves
authors.initials: JY
authors.lastname: Blay
authors.forename: Christophe
authors.initials: C
authors.lastname: Caux