title: Bromophycoic acids: bioactive natural products from a Fijian red alga Callophycus sp.
abstract: Bioassay-guided fractionation of extracts from a Fijian red alga in the genus Callophycus resulted in the isolation of five new compounds of the diterpene-benzoate class. Bromophycoic acids A-E (1-5) were characterized by NMR and mass spectroscopic analyses and represent two novel carbon skeletons, one with an unusual proposed biosynthesis. These compounds display a range of activities against human tumor cell lines, malarial parasites, and bacterial pathogens including low micromolar suppression of MRSA and VREF.
authors.affiliation: School of Biology, Aquatic Chemical Ecology Center, Institute of Bioengineering and Biosciences, Georgia Institute of Technology, Atlanta, Georgia 30332, USA.
authors.forename: Margaret E
authors.initials: ME
authors.lastname: Teasdale
authors.forename: Tonya L
authors.initials: TL
authors.lastname: Shearer
authors.forename: Sebastian
authors.initials: S
authors.lastname: Engel
authors.forename: Troy S
authors.initials: TS
authors.lastname: Alexander
authors.forename: Craig R
authors.initials: CR
authors.lastname: Fairchild
authors.forename: Jacques
authors.initials: J
authors.lastname: Prudhomme
authors.forename: Manuel
authors.initials: M
authors.lastname: Torres
authors.forename: Karine
authors.initials: K
authors.lastname: Le Roch
authors.forename: William
authors.initials: W
authors.lastname: Aalbersberg
authors.forename: Mark E
authors.initials: ME
authors.lastname: Hay
authors.forename: Julia
authors.initials: J
authors.lastname: Kubanek
mesh_terms: D001565:Benzoates / Q000737:chemistry* / Q000302:isolation & purification; D001688:Biological Products / Q000737:chemistry* / Q000302:isolation & purification; D045744:Cell Line, Tumor; D004224:Diterpenes / Q000737:chemistry* / Q000302:isolation & purification; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D000461:Rhodophyta
chemical_list: D001565:Benzoates; D001688:Biological Products; D004224:Diterpenes; C512010:bromophycolide A; C541882:bromophycolide B; C557930:bromophycolide D; C541883:bromophycolide E