title: Primary small cell neuroendocrine carcinoma of the endometrium.
abstract: BACKGROUND
  Small cell neuroendocrine carcinoma is very rarely encountered within the endometrium.
  
  
  METHODS
  A patient underwent a hysterectomy and salpingo-oophorectomy for a suspicious gynecologic condition. Pathology revealed invasive small cell neuroendocrine carcinoma of the endometrium; the neoplasm exhibited positive immunoreactivity for synaptophysin, pancytokeratin and CD56 but was negative for CD3 and CD20. Prior to chemotherapy, a completion lymphadenectomy was indicated to determine the presence of nodal metastases.
  
  
  CONCLUSIONS
  The prognosis of small cell neuroendocrine carcinoma of the endometrium is unfavorable but prompt detection with surgery and adjuvant therapy may confer a better clinical outcome.
authors.affiliation: Gynecologic Oncology Associates, Hoag Memorial Hospital Presbyterian, Newport Beach, Calif., USA.
authors.forename: Lisa N
authors.initials: LN
authors.lastname: Abaid
authors.forename: John S
authors.initials: JS
authors.lastname: Cupp
authors.forename: John V
authors.initials: JV
authors.lastname: Brown
authors.forename: Bram H
authors.initials: BH
authors.lastname: Goldstein