title: Carcinogenic effects of N-nitroso-3-(substituted phenylimino)-indolin-2-one derivatives.
abstract: OBJECTIVE
  A novel series of N-nitroso-3-(substituted phenylimino)-indolin-2-one 3a-h was synthesized and tested for carcinogenic effects.
  
  
  METHODS
  The synthesized pyrazole derivatives' chemical structures were proved by means of their infra red (IR), proton nuclear magnetic resonance ((1)H-NMR), and mass,and confirmed by elemental analyses. The carcinogenic activity was assessed by 3-(4,5dimethyl thiazole-2yl)-2,5-diphenyltetrazoliumbromide (MTT) cell-viability assay.
  
  
  RESULTS
  The results show that most of the synthesized compounds exhibit significant carcinogenic activities. Among the synthesized compounds, N-nitroso-3-(2,4-dinitrophenylimino)-indolin-2-one 3h exhibited the most potent carcinogenic activity.
  
  
  CONCLUSIONS
  The structure-activity relationship (SAR) studies show that the nature as well as the position of the amine are important for deciding the activity profile of the indolin-2-one derivatives, which reiterates the need for further experimental investigations.
authors.affiliation: Department of Chemical Engineering, University of Rovira i Virgili, 26, Av. Paisos Catalans, Tarragona, Spain.
authors.forename: Murali
authors.initials: M
authors.lastname: Kumarasamy
authors.forename: Panneerselvam
authors.initials: P
authors.lastname: Theivendren
authors.forename: Rousso
authors.initials: R
authors.lastname: Govindarajan
authors.forename: Scott G
authors.initials: SG
authors.lastname: Franzblau
authors.forename: Kirthiga
authors.initials: K
authors.lastname: Ramalingam