title: Design, synthesis, and biological evaluation of the analogues of glaziovianin A, a potent antitumor isoflavone.
abstract: Various analogues of glaziovianin A, an antitumor isoflavone, were synthesized, and their biological activities were evaluated. O(7)-modified glaziovianin A showed strong cytotoxicity against HeLa S(3) cells. Compared to glaziovianin A, the O(7)-benzyl and O(7)-propargyl analogues were more cytotoxic against HeLa S(3) cells and more potent M-phase inhibitors. Furthermore, O(7)-modified molecular probes of glaziovianin A were synthesized for biological studies.
authors.affiliation: Department of Chemistry, Graduate School of Pure and Applied Sciences, University of Tsukuba, Tennodai, Tsukuba 305-8571, Japan. hayakawa@chem.tsukuba.ac.jp
authors.forename: Ichiro
authors.initials: I
authors.lastname: Hayakawa
authors.forename: Akiyuki
authors.initials: A
authors.lastname: Ikedo
authors.forename: Takumi
authors.initials: T
authors.lastname: Chinen
authors.forename: Takeo
authors.initials: T
authors.lastname: Usui
authors.forename: Hideo
authors.initials: H
authors.lastname: Kigoshi
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D002470:Cell Survival / Q000187:drug effects; D015195:Drug Design; D006367:HeLa Cells; D006801:Humans; D007529:Isoflavones / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D059566:M Phase Cell Cycle Checkpoints / Q000187:drug effects; D009369:Neoplasms / Q000188:drug therapy; D013329:Structure-Activity Relationship
chemical_list: D000970:Antineoplastic Agents; D007529:Isoflavones; C521560:glaziovianin A