title: Molecular genetic analysis of influenza A/H3N2 virus strains isolated in Western Siberia in the 2010-2011 epidemic season.
abstract: Molecular genetic and antigenic features of influenza A/H3N2 virus strains isolated in Western Siberia in 2011 are similar to those of the vaccine strain A/Perth/16/2009 despite a number of unique amino-acid changes. The strains lack specific amino-acid changes in NA protein providing decrease of sensibility to NA inhibitors activity that used in medical practice. Based on phylogenic analysis of HA protein amino-acid sequences examined strains are similar to influenza A/H3N2 virus strains circulating at the moment in Eurasia.
authors.affiliation: State Research Center of Virology and Biotechnology Vector, Koltsovo, Novosibirsk 630559, Russia.
authors.forename: I
authors.initials: I
authors.lastname: Sobolev
authors.forename: O
authors.initials: O
authors.lastname: Kurskaya
authors.forename: I
authors.initials: I
authors.lastname: Susloparov
authors.forename: T
authors.initials: T
authors.lastname: Ilyicheva
authors.forename: A
authors.initials: A
authors.lastname: Shestopalov
mesh_terms: D000328:Adult; D000595:Amino Acid Sequence; D019943:Amino Acid Substitution; D002648:Child; D058872:Epidemics; D005260:Female; D019267:Hemagglutinin Glycoproteins, Influenza Virus / Q000235:genetics; D006801:Humans; D053122:Influenza A Virus, H3N2 Subtype / Q000145:classification / Q000235:genetics* / Q000302:isolation & purification; D007251:Influenza, Human / Q000453:epidemiology* / Q000821:virology*; D008297:Male; D017720:Molecular Epidemiology; D008969:Molecular Sequence Data; D010802:Phylogeny; D012800:Siberia / Q000453:epidemiology
chemical_list: D019267:Hemagglutinin Glycoproteins, Influenza Virus