title: Prompt or delayed appendectomy? Influence of timing of surgery for acute appendicitis.
abstract: OBJECTIVE
  The aim of the study was to compare the clinical outcomes and histological findings in prompt and delayed appendectomy for acute appendicitis.
  
  
  METHODS
  All patients who underwent appendectomy for histologically confirmed acute appendicitis from 2003 to 2009 were included in this study. Patients were divided into three groups according to the time of surgery after hospital admission: The early appendectomy (EA) group underwent surgery within 12 h, the early-delayed appendectomy (EDA) group between 12 and 24 h and the delayed appendectomy (DA) group more than 24 h. The perioperative data and pathological state of the appendix were evaluated and compared.
  
  
  RESULTS
  A total of 723 patients, with histologically confirmed acute appendicitis, were included in the study: There were 518 patients in the EA group, 140 patients in the EDA group and 65 patients in the DA group. The operative times were similar in each group. Postoperative complications occurred in 49 patients (6.8 %) and were significantly higher in the DA group in comparison to the EA group (p = 0.0012) and EDA group (p = 0.003). Two patients (3 %) in the DA group died. There were no differences in the length of the hospital stay. The gangrenous appendicitis rate was significantly higher in the DA group (p < 0.05) in comparison to the EA and EDA groups.
  
  
  CONCLUSIONS
  Performing appendectomy within 24 h from presentation does not increase the length of hospital stay or rate of complications. However, delayed appendectomy after 24 h from onset increases the rate of complications.
authors.affiliation: Department of General Surgery, A.S.O. Santa Croce e Carle, Via Michele Coppino, no. 14, Cuneo, Italy. giorgiogiraudo@hotmail.com
authors.forename: Giorgio
authors.initials: G
authors.lastname: Giraudo
authors.forename: Filippo
authors.initials: F
authors.lastname: Baracchi
authors.forename: Luca
authors.initials: L
authors.lastname: Pellegrino
authors.forename: Herbert M
authors.initials: HM
authors.lastname: Dal Corso
authors.forename: Felice
authors.initials: F
authors.lastname: Borghi
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001062:Appendectomy / Q000379:methods*; D001064:Appendicitis / Q000601:surgery*; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007902:Length of Stay / Q000706:statistics & numerical data; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications / Q000453:epidemiology; D012189:Retrospective Studies; D013997:Time Factors; D016896:Treatment Outcome; D055815:Young Adult