title: The biological roles of ITGB4BP and its potential effect on fibrosis.
abstract: Fibrosis is the end result of pathologic wound healing and is characterized by inflammation, excessive proliferation of fibroblasts, and abnormal deposition of extracellular matrix (ECM) proteins. Despite the advanced treatments for the fibrotic diseases, as well as the researches on the fibrosis, pathologic fibrotic diseases remain to be hard cured and the molecular mechanism of fibrosis is still unclear. In our previous studies we found ITGB4BP was involved in the myofibroblast differentiation. However there were no studies about the roles of ITGB4BP in fibrosis. On this background this review explores the basic features and the biological function of ITGB4BP which might imply the underlying cellular and molecular mechanism in the regulation of fibrotic diseases.
authors.affiliation: Institute of Burn Research, State Key Laboratory for Trauma, Burns and Combined Injury, Chongqing Key Laboratory for Disease Proteomics, Southwest Hospital, Third Military Medical University Chongqing 400038, China.
authors.forename: Jianglin
authors.initials: J
authors.lastname: Tan
authors.forename: Gaoxing
authors.initials: G
authors.lastname: Luo
authors.forename: Jun
authors.initials: J
authors.lastname: Wu