title: Implementation and development of an automated, ultra-high-capacity, acoustic, flexible dispensing platform for assay-ready plate delivery.
abstract: Compound management faces the daily challenge of providing high-quality samples to drug discovery. The advent of new screening technologies has seen demand for liquid samples move toward nanoliter ranges, dispensed by contactless acoustic droplet ejection. Within AstraZeneca, a totally integrated assay-ready plate production platform has been created to fully exploit the advantages of this technology. This enables compound management to efficiently deliver large throughputs demanded by high-throughput screening while maintaining regular delivery of smaller numbers of compounds in varying plate formats for cellular or biochemical concentration-response curves in support of hit and lead optimization (structure-activity relationship screening). The automation solution, CODA, has the capability to deliver compounds on demand for single- and multiple-concentration ranges, in batch sizes ranging from 1 sample to 2 million samples, integrating seamlessly into local compound and test management systems. The software handles compound orders intelligently, grouping test requests together dependent on output plate type and serial dilution ranges so that source compound vessels are shared among numerous tests, ensuring conservation of sample, reduced labware and costs, and efficiency of work cell logistics. We describe the development of CODA to address the customer demand, challenges experienced, learning made, and subsequent enhancements.
authors.affiliation: AstraZeneca PLC, Macclesfield, Cheshire, UK. dylan.griffith@astrazeneca.com
authors.forename: Dylan
authors.initials: D
authors.lastname: Griffith
authors.forename: Roger
authors.initials: R
authors.lastname: Northwood
authors.forename: Paul
authors.initials: P
authors.lastname: Owen
authors.forename: Ellen
authors.initials: E
authors.lastname: Simkiss
authors.forename: Andrew
authors.initials: A
authors.lastname: Brierley
authors.forename: Kevin
authors.initials: K
authors.lastname: Cross
authors.forename: Andrew
authors.initials: A
authors.lastname: Slaney
authors.forename: Miranda
authors.initials: M
authors.lastname: Davis
authors.forename: Colin
authors.initials: C
authors.lastname: Bath
mesh_terms: D000162:Acoustics; D057205:Automation, Laboratory / Q000379:methods*; D004353:Drug Evaluation, Preclinical / Q000379:methods; D057166:High-Throughput Screening Assays; D006801:Humans; D021281:Quantitative Structure-Activity Relationship; D012984:Software; D013048:Specimen Handling / Q000379:methods*; D013678:Technology, Pharmaceutical / Q000379:methods