title: Incidence and genetic aspects of patellar luxation in Pomeranian dogs in Thailand.
abstract: There is a high incidence of patellar luxation (PL) in Pomeranian dogs from Thailand. DNA samples were collected from 59 dogs originating from 15 families. PL was present in 75% of the dogs with a male:female ratio of 1:1.95. Polymorphic microsatellites situated close to the COL6A1, COL6A3, COL9A1, COL9A2, and COL9A3 genes were analyzed for linkage to the phenotype. Sibling-pair analysis revealed that none of the collagen markers analyzed had a high non-parametric linkage score with the highest score, 1.56, for COL9A2 (P=0.07). The low LOD scores for these collagen genes indicated a non-involvement in the pathogenesis of PL in Pomeranians. An association study with a low density single nucleotide polymorphism (SNP) set indicated the possible involvement of a region on chromosome 7. The association of this region remained indicative when larger groups of 43 cases and 40 controls were compared (Chi square test P=0.01).
authors.affiliation: Department of Veterinary Surgery, Faculty of Veterinary Science, Chulalongkorn University, 39 Henri Dunant, Bangkok 10330, Thailand.
authors.forename: K
authors.initials: K
authors.lastname: Soontornvipart
authors.forename: C
authors.initials: C
authors.lastname: Wangdee
authors.forename: M
authors.initials: M
authors.lastname: Kalpravidh
authors.forename: A
authors.initials: A
authors.lastname: Brahmasa
authors.forename: M
authors.initials: M
authors.lastname: Sarikaputi
authors.forename: J
authors.initials: J
authors.lastname: Temwichitr
authors.forename: I C M
authors.initials: IC
authors.lastname: Lavrijsen
authors.forename: L F H
authors.initials: LF
authors.lastname: Theyse
authors.forename: P A J
authors.initials: PA
authors.lastname: Leegwater
authors.forename: H A W
authors.initials: HA
authors.lastname: Hazewinkel
mesh_terms: D000818:Animals; D003094:Collagen / Q000235:genetics* / Q000378:metabolism; D004283:Dog Diseases / Q000453:epidemiology / Q000235:genetics*; D004285:Dogs; D005260:Female; D008040:Genetic Linkage; D015994:Incidence; D008297:Male; D018895:Microsatellite Repeats; D010329:Patella / Q000473:pathology*; D010641:Phenotype; D020641:Polymorphism, Single Nucleotide; D013785:Thailand
chemical_list: D003094:Collagen