title: Surfaces resistant to fouling from biological fluids: towards bioactive surfaces for real applications.
abstract: The fouling from four human body fluids - blood plasma, cerebrospinal fluid, urine and saliva - and four animal fluids - foetal bovine and calf sera, egg and milk - relevant to human and veterinary medicine, immunology, biology and diagnostics is assessed on antifouling SAMs and on polymer brushes of oligo(ethylene glycol) methacrylate, 2-hydroxyethyl methacrylate, carboxybetaine acrylamide and N-(2-hydroxypropyl)methacrylamide synthesized via ATRP. While important deposits from the all biofluids are observed on SAMs, a superior resistance is achieved on polymer brushes. Importantly, only poly(CBAA) and poly(HPMA) are capable of resisting the fouling from the most challenging media, blood plasma and eggs.
authors.affiliation: Institute of Macromolecular Chemistry, Academy of Sciences of the Czech Republic, v.v.i., Prague, Czech Republic. rodriguez@imc.cas.cz
authors.forename: Cesar
authors.initials: C
authors.lastname: Rodriguez-Emmenegger
authors.forename: Milan
authors.initials: M
authors.lastname: Houska
authors.forename: Aldo Bologna
authors.initials: AB
authors.lastname: Alles
authors.forename: Eduard
authors.initials: E
authors.lastname: Brynda
mesh_terms: D000180:Acrylic Resins / Q000138:chemical synthesis* / Q000494:pharmacology; D000818:Animals; D001419:Bacteria / Q000187:drug effects* / Q000254:growth & development; D001826:Body Fluids / Q000737:chemistry; D002417:Cattle; D020099:Coated Materials, Biocompatible / Q000138:chemical synthesis* / Q000494:pharmacology; D004202:Disinfectants / Q000138:chemical synthesis* / Q000494:pharmacology; D004531:Eggs / Q000032:analysis; D006801:Humans; D008892:Milk / Q000737:chemistry; D017550:Spectroscopy, Fourier Transform Infrared; D013499:Surface Properties
chemical_list: D000180:Acrylic Resins; D020099:Coated Materials, Biocompatible; D004202:Disinfectants