title: Expeditious synthesis of tetrasubstituted helical alkenes by a cascade of palladium-catalyzed C-H activations.
abstract: Twisted molecules: A modular approach for the synthesis of tetrasubstituted helical alkenes by a palladium-catalyzed norbornene-mediated domino reaction is presented. This intermolecular domino process allows the formation of three C-C bonds in one operation through a C-H activation/carbopalladation/C-H activation sequence.
authors.affiliation: Department of Chemistry, University of Toronto, Toronto, Ontario, Canada.
authors.forename: Hongqiang
authors.initials: H
authors.lastname: Liu
authors.forename: Mohamed
authors.initials: M
authors.lastname: El-Salfiti
authors.forename: Mark
authors.initials: M
authors.lastname: Lautens
mesh_terms: D000475:Alkenes / Q000138:chemical synthesis* / Q000737:chemistry; D002384:Catalysis; D008958:Models, Molecular; D010165:Palladium / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D000475:Alkenes; D010165:Palladium