title: [Markers of prodromal Alzheimer's disease].
abstract: The diagnosis of Alzheimer's disease has long been considered a diagnosis of probability, as the definitive diagnosis can only be established by histopathological examination. However, the development of in-vivo biomarkers, considered a reflection of physiopathological processes, has changed our view of the disease. New criteria have recently been proposed that integrate such biomarkers as found in the cerebrospinal fluid (CSF) using new diagnostic tools such as magnetic resonance imaging (MRI), brain scintigraphy, FDG-positron emission tomography (PET) and PET amyloid ligand uptake studies. The value of these new criteria for the diagnosis of prodromal Alzheimer's disease and the prospect of disease-modifying drugs are also discussed.
authors.affiliation: Hôpital de la Pitié-Salpêtrière, institut de la mémoire et de la maladie d'Alzheimer, AP-HP, 47-83 boulevard de l'Hôpital, Paris, France.
authors.forename: L C
authors.initials: LC
authors.lastname: de Souza
authors.forename: M
authors.initials: M
authors.lastname: Sarazin
authors.forename: O
authors.initials: O
authors.lastname: Uspenskaya
authors.forename: M-O
authors.initials: MO
authors.lastname: Habert
authors.forename: F
authors.initials: F
authors.lastname: Lamari
authors.forename: S
authors.initials: S
authors.lastname: Lehéricy
authors.forename: B
authors.initials: B
authors.lastname: Dubois
mesh_terms: D000544:Alzheimer Disease / Q000134:cerebrospinal fluid / Q000175:diagnosis* / Q000473:pathology; D016229:Amyloid beta-Peptides / Q000032:analysis / Q000134:cerebrospinal fluid; D015415:Biomarkers / Q000032:analysis*; D001921:Brain / Q000000981:diagnostic imaging; D003952:Diagnostic Imaging / Q000379:methods; D042241:Early Diagnosis; D006801:Humans; D008954:Models, Biological; D062706:Prodromal Symptoms; D011859:Radiography; D011877:Radionuclide Imaging; D016875:tau Proteins / Q000032:analysis / Q000134:cerebrospinal fluid
chemical_list: D016229:Amyloid beta-Peptides; D015415:Biomarkers; D016875:tau Proteins