title: Factors associated with health-related quality of life in a cohort of Spanish breast cancer patients.
abstract: BACKGROUND
  Several factors can modify health-related quality of life (HRQOL) of breast cancer survivors. The objective of the current study was to analyse the associations between HRQOL scores 1 year after breast cancer surgery and sociodemographic and clinical factors.
  
  
  METHODS
  This was an observational, multicentre and prospective study of a cohort of patients who underwent oncological breast cancer surgery and which was followed up for 1 year. The HRQOL was assessed at 1 year after surgery using three questionnaires: EuroQol-5D, EORTC QLQ-C30 and its breast-specific module BR-23.
  
  
  RESULTS
  A total of 364 patients participated in the study. Some factors were associated with better HRQOL 1 year after surgery: age between 60 and 69 years and under 50 years, being single or a housewife, stage I-II, invasive papillary carcinoma, breast-conserving surgery (BCS) or lack of axillary dissection. However, only the following were independent predictive factors: being single or a housewife, BCS, invasive papillary carcinoma, coming from an outpatient clinic or not receiving radiotherapy. Further, some factors were independent predictors of a worse HRQOL: age over 70 years, being married, separated or widowed, stage III or not receiving adjuvant chemotherapy.
  
  
  CONCLUSIONS
  Demographic and clinical factors can influence HRQOL, some of them independently.
authors.affiliation: Department of Surgery, Hospital Clínico Universitario de Valencia, Valencia, Spain, davidmoro78@gmail.com.
authors.forename: David
authors.initials: D
authors.lastname: Moro-Valdezate
authors.forename: Elvira
authors.initials: E
authors.lastname: Buch-Villa
authors.forename: Salvador
authors.initials: S
authors.lastname: Peiró
authors.forename: M Dolores
authors.initials: MD
authors.lastname: Morales-Monsalve
authors.forename: Antonio
authors.initials: A
authors.lastname: Caballero-Gárate
authors.forename: Ángel
authors.initials: Á
authors.lastname: Martínez-Agulló
authors.forename: Félix
authors.initials: F
authors.lastname: Checa-Ayet
authors.forename: Joaquín
authors.initials: J
authors.lastname: Ortega-Serrano
mesh_terms: D000368:Aged; D001943:Breast Neoplasms / Q000473:pathology / Q000601:surgery*; D018270:Carcinoma, Ductal, Breast / Q000473:pathology / Q000601:surgery*; D018275:Carcinoma, Lobular / Q000473:pathology / Q000601:surgery*; D002291:Carcinoma, Papillary / Q000473:pathology / Q000601:surgery*; D005260:Female; D005500:Follow-Up Studies; D006304:Health Status; D006801:Humans; D008408:Mastectomy; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D009367:Neoplasm Staging; D011379:Prognosis; D011446:Prospective Studies; D011788:Quality of Life; D013030:Spain; D011795:Surveys and Questionnaires; D017741:Survivors