title: Screen anti-influenza lead compounds that target the PA(C) subunit of H5N1 viral RNA polymerase.
abstract: The avian influenza (H5N1) viral RNA polymerase protein PA(C) was used as a target to screen nine chlorogenic acid derivatives for their polymerase inhibitor activity. Among them, seven compounds were PA(C) ligands, and four inhibited influenza RNA polymerase activity. These results aid in the design of anti-influenza agents based on caffeoylquinic acid.
authors.affiliation: Beijing National Laboratory for Molecular Sciences, Center for Molecular Sciences, State Key Laboratory for Structural Chemistry of Unstable and Stable Species, Institute of Chemistry, Chinese Academy of Sciences, Beijing, China.
authors.forename: Lin
authors.initials: L
authors.lastname: Li
authors.forename: Shenghai
authors.initials: S
authors.lastname: Chang
authors.forename: Junfeng
authors.initials: J
authors.lastname: Xiang
authors.forename: Qian
authors.initials: Q
authors.lastname: Li
authors.forename: Huanhuan
authors.initials: H
authors.lastname: Liang
authors.forename: Yalin
authors.initials: Y
authors.lastname: Tang
authors.forename: Yingfang
authors.initials: Y
authors.lastname: Liu
mesh_terms: D000998:Antiviral Agents / Q000737:chemistry / Q000494:pharmacology*; D012321:DNA-Directed RNA Polymerases / Q000037:antagonists & inhibitors*; D015195:Drug Design; D004353:Drug Evaluation, Preclinical; D006801:Humans; D053124:Influenza A Virus, H5N1 Subtype / Q000201:enzymology*; D009682:Magnetic Resonance Spectroscopy; D011801:Quinic Acid / Q000031:analogs & derivatives / Q000737:chemistry; D014764:Viral Proteins / Q000037:antagonists & inhibitors*
chemical_list: D000998:Antiviral Agents; D014764:Viral Proteins; C472707:caffeoylquinic acid; D011801:Quinic Acid; D012321:DNA-Directed RNA Polymerases