title: Regulation of ROS production and vascular function by carbon monoxide.
abstract: Carbon monoxide (CO) is a gaseous molecule produced from heme by heme oxygenase (HO). CO interacts with reduced iron of heme-containing proteins, leading to its involvement in various cellular events via its production of mitochondrial reactive oxygen species (ROS). CO-mediated ROS production initiates intracellular signal events, which regulate the expression of adaptive genes implicated in oxidative stress and functions as signaling molecule for promoting vascular functions, including angiogenesis and mitochondrial biogenesis. Therefore, CO generated either by exogenous delivery or by HO activity can be fundamentally involved in regulating mitochondria-mediated redox cascades for adaptive gene expression and improving blood circulation (i.e., O(2) delivery) via neovascularization, leading to the regulation of mitochondrial energy metabolism. This paper will highlight the biological effects of CO on ROS generation and cellular redox changes involved in mitochondrial metabolism and angiogenesis. Moreover, cellular mechanisms by which CO is exploited for disease prevention and therapeutic applications will also be discussed.
authors.affiliation: Department of Molecular and Cellular Biochemistry, School of Medicine, Kangwon National University, Chuncheon, Gangwon-do 200-701, Republic of Korea.
authors.forename: Yoon Kyung
authors.initials: YK
authors.lastname: Choi
authors.forename: Elaine D
authors.initials: ED
authors.lastname: Por
authors.forename: Young-Guen
authors.initials: YG
authors.lastname: Kwon
authors.forename: Young-Myeong
authors.initials: YM
authors.lastname: Kim
mesh_terms: D000818:Animals; D001808:Blood Vessels / Q000187:drug effects* / Q000502:physiology*; D002248:Carbon Monoxide / Q000494:pharmacology* / Q000627:therapeutic use; D006801:Humans; D018919:Neovascularization, Physiologic / Q000187:drug effects; D010084:Oxidation-Reduction / Q000187:drug effects; D017382:Reactive Oxygen Species / Q000378:metabolism*; D014652:Vascular Diseases / Q000188:drug therapy / Q000473:pathology / Q000503:physiopathology
chemical_list: D017382:Reactive Oxygen Species; D002248:Carbon Monoxide