title: Endocrine and metabolic regulation of renal drug transporters.
abstract: Renal xenobiotic transporters are important determinants of urinary secretion and reabsorption of chemicals. In addition to glomerular filtration, these processes are key to the overall renal clearance of a diverse array of drugs and toxins. Alterations in kidney transporter levels and function can influence the efficacy and toxicity of chemicals. Studies in experimental animals have revealed distinct patterns of renal transporter expression in response to sex hormones, pregnancy, and growth hormone. Likewise, a number of disease states including diabetes, obesity, and cholestasis alter the expression of kidney transporters. The goal of this review is to provide an overview of the major xenobiotic transporters expressed in the kidneys and an understanding of metabolic conditions and hormonal factors that regulate their expression and function.
authors.affiliation: Department of Pharmacology and Toxicology, Rutgers University Ernest Mario School of Pharmacy, Piscataway, NJ 08854-8020, USA.
authors.forename: Lindsay L
authors.initials: LL
authors.lastname: Yacovino
authors.forename: Lauren M
authors.initials: LM
authors.lastname: Aleksunes
mesh_terms: D018528:ATP-Binding Cassette Transporters / Q000235:genetics / Q000378:metabolism* / Q000502:physiology; D000818:Animals; D003920:Diabetes Mellitus / Q000378:metabolism / Q000503:physiopathology; D005260:Female; D005786:Gene Expression Regulation; D042341:Gonadal Hormones / Q000502:physiology; D013006:Growth Hormone / Q000502:physiology; D006801:Humans; D007668:Kidney / Q000378:metabolism* / Q000503:physiopathology; D009765:Obesity / Q000378:metabolism / Q000503:physiopathology; D027361:Organic Anion Transporters / Q000235:genetics / Q000378:metabolism* / Q000502:physiology; D027701:Organic Cation Transport Proteins / Q000235:genetics / Q000378:metabolism* / Q000502:physiology; D011247:Pregnancy
chemical_list: D018528:ATP-Binding Cassette Transporters; D042341:Gonadal Hormones; D027361:Organic Anion Transporters; D027701:Organic Cation Transport Proteins; D013006:Growth Hormone