title: IDegAsp: a novel soluble insulin analogs combination.
abstract: BACKGROUND
  Current rapid- and long-acting insulin analogs cannot maintain their individual pharmacokinetic profile when they are co-formulated. IDegAsp , a novel soluble combination was developed with rapid-acting insulin aspart and a new-generation ultra-long-acting insulin, insulin degludec and was anticipated to offer clinical advantage over available premixed insulin suspensions.
  
  
  METHODS
  We reviewed published data regarding pharmacological characters, clinical efficacy, safety, and tolerability of IDegAsp. Literature was searched through the electronic medical databases (PubMed, EMBASE, and Web of Knowledge) up to June 2012.
  
  
  CONCLUSIONS
  Preliminary clinical data indicate that IDegAsp is a safe, well-tolerated insulin combination and provides a similar overall glycemic control to current insulin preparations with a reduced risk of hypoglycemia. IDegAsp might be a promising treatment option for patients with type 2 diabetes who need to improve control of postprandial glucose excursions and fasting glucose levels.
authors.affiliation: Aarhus University Hospital, Department of Endocrinology and Internal Medicine, Norrebrogade 44, Aarhus, 8000, Denmark. joli.mzl@gmail.com
authors.forename: Zhulin
authors.initials: Z
authors.lastname: Ma
authors.forename: Tina
authors.initials: T
authors.lastname: Parkner
authors.forename: Jens Sandahl
authors.initials: JS
authors.lastname: Christiansen
authors.forename: Torben
authors.initials: T
authors.lastname: Laursen
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D001786:Blood Glucose / Q000187:drug effects / Q000378:metabolism; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000188:drug therapy*; D006801:Humans; D007004:Hypoglycemic Agents / Q000008:administration & dosage*; D007328:Insulin / Q000008:administration & dosage* / Q000031:analogs & derivatives* / Q000235:genetics; D049528:Insulin, Long-Acting / Q000008:administration & dosage / Q000235:genetics; D008969:Molecular Sequence Data
chemical_list: D001786:Blood Glucose; D007004:Hypoglycemic Agents; D007328:Insulin; D049528:Insulin, Long-Acting; C571886:insulin degludec