title: Therapeutic zinc and copper supplementation in acute diarrhea does not influence short-term morbidity and growth:  double-blind randomized controlled trial.
abstract: Our objective was to evaluate the effect of zinc and copper supplementation in acute diarrhea on morbidity and growth during 12 weeks of follow-up. In a double-blind randomized controlled clinical trial of 724 children aged 6-59 months, none of the 11 evaluated outcomes showed significant association with zinc or zinc and copper supplementation. Thus, therapeutic zinc supplementation may not always yield short-term -benefits.
authors.affiliation: Lata Medical Research Foundation, Indira Gandhi Government Medical College, Nagpur, India.
authors.forename: Archana B
authors.initials: AB
authors.lastname: Patel
authors.forename: Michael J
authors.initials: MJ
authors.lastname: Dibley
authors.forename: Manju
authors.initials: M
authors.lastname: Mamtani
authors.forename: Neetu
authors.initials: N
authors.lastname: Badhoniya
authors.forename: Hemant
authors.initials: H
authors.lastname: Kulkarni
mesh_terms: D000208:Acute Disease; D000284:Administration, Oral; D000704:Analysis of Variance; D049628:Body Size / Q000187:drug effects; D016009:Chi-Square Distribution; D002675:Child, Preschool; D003300:Copper / Q000008:administration & dosage*; D003967:Diarrhea / Q000178:diet therapy*; D019587:Dietary Supplements; D004311:Double-Blind Method; D006801:Humans; D007223:Infant; D009017:Morbidity; D016896:Treatment Outcome; D015032:Zinc / Q000008:administration & dosage*
chemical_list: D003300:Copper; D015032:Zinc