title: Sentinel lymph node biopsy at the time of mastectomy does not increase the risk of lymphedema: implications for prophylactic surgery.
abstract: Women diagnosed with or at high risk for breast cancer increasingly choose prophylactic mastectomy. It is unknown if adding sentinel lymph node biopsy (SLNB) to prophylactic mastectomy increases the risk of lymphedema. We sought to determine the risk of lymphedema after mastectomy with and without nodal evaluation. 117 patients who underwent bilateral mastectomy were prospectively screened for lymphedema. Perometer arm measurements were used to calculate weight-adjusted arm volume change at each follow-up. Of 234 mastectomies performed, 15.8 % (37/234) had no axillary surgery, 63.7 % (149/234) had SLNB, and 20.5 % (48/234) had axillary lymph node dissection (ALND). 88.0 % (103/117) of patients completed the LEFT-BC questionnaire evaluating symptoms associated with lymphedema. Multivariate analysis was used to assess clinical characteristics associated with increased weight-adjusted arm volume and patient-reported lymphedema symptoms. SLNB at the time of mastectomy did not result in an increased mean weight-adjusted arm volume compared to mastectomy without axillary surgery (p = 0.76). Mastectomy with ALND was associated with a significantly greater mean weight-adjusted arm volume change compared to mastectomy with SLNB (p < 0.0001) and without axillary surgery (p = 0.0028). Patients who underwent mastectomy with ALND more commonly reported symptoms associated with lymphedema compared to those with SLNB or no axillary surgery (p < 0.0001). Patients who underwent mastectomy with SLNB or no axillary surgery reported similar lymphedema symptoms. Addition of SLNB to mastectomy is not associated with a significant increase in measured or self-reported lymphedema rates. Therefore, SLNB may be performed at the time of prophylactic mastectomy without an increased risk of lymphedema.
authors.affiliation: Department of Radiation Oncology, Massachusetts General Hospital, Boston, MA 02114, USA.
authors.forename: Cynthia L
authors.initials: CL
authors.lastname: Miller
authors.forename: Michelle C
authors.initials: MC
authors.lastname: Specht
authors.forename: Melissa N
authors.initials: MN
authors.lastname: Skolny
authors.forename: Lauren S
authors.initials: LS
authors.lastname: Jammallo
authors.forename: Nora
authors.initials: N
authors.lastname: Horick
authors.forename: Jean
authors.initials: J
authors.lastname: O'Toole
authors.forename: Suzanne B
authors.initials: SB
authors.lastname: Coopey
authors.forename: Kevin
authors.initials: K
authors.lastname: Hughes
authors.forename: Michele
authors.initials: M
authors.lastname: Gadd
authors.forename: Barbara L
authors.initials: BL
authors.lastname: Smith
authors.forename: Alphonse G
authors.initials: AG
authors.lastname: Taghian
mesh_terms: D000328:Adult; D000368:Aged; D001132:Arm / Q000473:pathology; D001365:Axilla / Q000601:surgery; D015992:Body Mass Index; D001943:Breast Neoplasms / Q000601:surgery*; D005260:Female; D006801:Humans; D008197:Lymph Node Excision / Q000009:adverse effects; D008209:Lymphedema / Q000209:etiology* / Q000628:therapy; D008408:Mastectomy; D008875:Middle Aged; D015999:Multivariate Analysis; D011184:Postoperative Period; D011315:Preventive Medicine / Q000379:methods; D011446:Prospective Studies; D012307:Risk Factors; D021701:Sentinel Lymph Node Biopsy / Q000009:adverse effects*; D055815:Young Adult