title: Influence of vehicles used for oral dosing of test molecules on the progression of Mycobacterium tuberculosis infection in mice.
abstract: Preclinical evaluation of drug-like molecules requires their oral administration to experimental animals using suitable vehicles. We studied the effect of oral dosing with corn oil, carboxymethyl cellulose, dimethyl sulfoxide, and polysorbate-80 on the progression of Mycobacterium tuberculosis infection in mice. Infection was monitored by physical (survival time and body weight) and bacteriological (viable counts in lungs) parameters. Compared with water, corn oil significantly improved both sets of parameters, whereas the other vehicles affected only physical parameters.
authors.affiliation: Drug Target Discovery and Development Division, Central Drug Research Institute, Lucknow, India.
authors.forename: Shubhra
authors.initials: S
authors.lastname: Singh
authors.forename: Richa
authors.initials: R
authors.lastname: Dwivedi
authors.forename: Vinita
authors.initials: V
authors.lastname: Chaturvedi
mesh_terms: D000284:Administration, Oral; D000818:Animals; D058491:Bacterial Load / Q000187:drug effects; D001835:Body Weight / Q000187:drug effects; D002266:Carboxymethylcellulose Sodium / Q000494:pharmacology*; D003314:Corn Oil / Q000494:pharmacology*; D004121:Dimethyl Sulfoxide / Q000494:pharmacology*; D018450:Disease Progression; D004337:Drug Carriers / Q000494:pharmacology*; D005260:Female; D008168:Lung / Q000187:drug effects / Q000382:microbiology / Q000473:pathology; D051379:Mice; D009169:Mycobacterium tuberculosis / Q000187:drug effects* / Q000254:growth & development; D011136:Polysorbates / Q000494:pharmacology*; D015996:Survival Rate; D014397:Tuberculosis, Pulmonary / Q000382:microbiology* / Q000401:mortality / Q000473:pathology; D014867:Water / Q000494:pharmacology*
chemical_list: D004337:Drug Carriers; D011136:Polysorbates; D014867:Water; D003314:Corn Oil; D002266:Carboxymethylcellulose Sodium; D004121:Dimethyl Sulfoxide