title: Combination fibrinolytic therapy in the treatment of chronic septic pleuropneumonia in a Thoroughbred gelding.
abstract: This report documents the treatment of a case of chronic pleuropneumonia in a 3-year-old Thoroughbred gelding. A recombinant tissue plasminogen activator (tenecteplase) and a recombinant deoxyribonucleic acidase (alphadornase) were infused into the pleural cavity as adjunctive therapy in the early stages of treatment. Instillation of fibrinolytic drugs was associated with a subjective reduction in the amount of fibrin deposition and decreased fluid accumulation within the pleural cavities. Fibrinolytic therapy may be a useful adjunctive therapy in selected cases of intrapleural disease in horses.
authors.affiliation: School of Animal and Veterinary Sciences, Charles Sturt University, Wagga Wagga, New South Wales, Australia. daverendle@btinternet.com
authors.forename: D I
authors.initials: DI
authors.lastname: Rendle
authors.forename: S K
authors.initials: SK
authors.lastname: Armstrong
authors.forename: K J
authors.initials: KJ
authors.lastname: Hughes
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D005343:Fibrinolytic Agents / Q000627:therapeutic use*; D006734:Horse Diseases / Q000188:drug therapy*; D006736:Horses; D008297:Male; D010996:Pleural Effusion / Q000188:drug therapy / Q000662:veterinary; D011001:Pleuropneumonia / Q000188:drug therapy / Q000662:veterinary*; D012481:Salmonella Infections, Animal / Q000188:drug therapy; D013290:Streptococcal Infections / Q000188:drug therapy / Q000662:veterinary; D018502:Streptococcus equi / Q000302:isolation & purification; D015912:Thrombolytic Therapy / Q000662:veterinary*; D010959:Tissue Plasminogen Activator / Q000627:therapeutic use*; D016896:Treatment Outcome
chemical_list: D000900:Anti-Bacterial Agents; D005343:Fibrinolytic Agents; D010959:Tissue Plasminogen Activator