title: Dietary chlorophyll metabolites catalyze the photoreduction of plasma ubiquinone.
abstract: Ubiquinol is a plasma antioxidant. The mechanisms responsible for maintenance of plasma ubiquinol are poorly understood. Here, we show that metabolites of chlorophyll can be found in blood plasma of animals that are given a chlorophyll-rich diet. We also show that these metabolites catalyze the reduction of plasma ubiquinone to ubiquinol in the presence of ambient light, in vitro. We propose that dietary chlorophyll or its metabolites, together with light exposure, regulate plasma redox status through maintaining the ubiquinol pool.
authors.affiliation: Department of Ophthalmology of Peking University, Beijing, China.
authors.forename: Jinfeng
authors.initials: J
authors.lastname: Qu
authors.forename: Li
authors.initials: L
authors.lastname: Ma
authors.forename: Junhua
authors.initials: J
authors.lastname: Zhang
authors.forename: Steffen
authors.initials: S
authors.lastname: Jockusch
authors.forename: Ilyas
authors.initials: I
authors.lastname: Washington
mesh_terms: D000821:Animal Feed; D000818:Animals; D055162:Biocatalysis / Q000528:radiation effects; D002417:Cattle; D002734:Chlorophyll / Q000737:chemistry / Q000378:metabolism*; D002851:Chromatography, High Pressure Liquid; D006801:Humans; D008027:Light; D015227:Lipid Peroxidation / Q000528:radiation effects; D051379:Mice; D010084:Oxidation-Reduction; D010782:Photolysis; D013050:Spectrometry, Fluorescence; D014451:Ubiquinone / Q000031:analogs & derivatives* / Q000097:blood*
chemical_list: D014451:Ubiquinone; D002734:Chlorophyll; C003741:ubiquinol