title: [Calcium signaling in T lymphocytes].
abstract: Calcium signaling is essential for all the functions of T lymphocytes, including those of Th2 cells. Th2 lymphocytes producing interleukins 4, 5 and 13 orchestrate allergic diseases including asthma. T-cell activation induces an influx of Ca(2+) from the external medium through ORAI calcium channels although other calcium channels are likely to be involved. Among them, voltage-gated calcium (Ca(v)1) channels have been reported in some T-cell subsets including Th2 cells. The inhibition of Ca(v)1 channels abrogates T-cell receptor-driven calcium influx and interleukin production by Th2 cells. From a therapeutic point of view, the inhibition of Ca(v)1 channels prevents Th2-dependent experimental allergic asthma. In this review, we will discuss the singularities of calcium responses depending upon the T-cell subset and its state of activation.
authors.affiliation: Inserm U1043, centre de physiopathologie de Toulouse Purpan, place du Docteur Baylac, BP 3028, 31024 Toulouse Cedex 3, France. virginie.robert@inserm.fr
authors.forename: Virginie
authors.initials: V
authors.lastname: Robert
authors.forename: Emily
authors.initials: E
authors.lastname: Triffaux
authors.forename: Magali
authors.initials: M
authors.lastname: Savignac
authors.forename: Lucette
authors.initials: L
authors.lastname: Pelletier
mesh_terms: D000818:Animals; D001249:Asthma / Q000188:drug therapy / Q000276:immunology / Q000503:physiopathology; D002121:Calcium Channel Blockers / Q000494:pharmacology / Q000627:therapeutic use; D015220:Calcium Channels / Q000172:deficiency / Q000187:drug effects / Q000502:physiology*; D020746:Calcium Channels, L-Type / Q000187:drug effects / Q000502:physiology; D020013:Calcium Signaling / Q000187:drug effects / Q000502:physiology; D002451:Cell Compartmentation; D006801:Humans; D006967:Hypersensitivity / Q000188:drug therapy / Q000276:immunology / Q000503:physiopathology; D007378:Interleukins / Q000378:metabolism; D008562:Membrane Glycoproteins / Q000172:deficiency; D008565:Membrane Proteins / Q000502:physiology; D051379:Mice; D018345:Mice, Knockout; D018448:Models, Immunological; D009363:Neoplasm Proteins / Q000502:physiology; D000071740:ORAI1 Protein; D053422:Receptor-Interacting Protein Serine-Threonine Kinases / Q000502:physiology; D000071737:Stromal Interaction Molecule 1; D016176:T-Lymphocyte Subsets / Q000187:drug effects / Q000276:immunology / Q000502:physiology*; D018418:Th2 Cells / Q000187:drug effects / Q000276:immunology / Q000502:physiology
chemical_list: D002121:Calcium Channel Blockers; D015220:Calcium Channels; D020746:Calcium Channels, L-Type; D007378:Interleukins; D008562:Membrane Glycoproteins; D008565:Membrane Proteins; D009363:Neoplasm Proteins; D000071740:ORAI1 Protein; C510746:ORAI1 protein, human; C520430:Orai1 protein, mouse; C103530:STIM1 protein, human; C100757:Stim1 protein, mouse; D000071737:Stromal Interaction Molecule 1; C119705:RIPK3 protein, human; D053422:Receptor-Interacting Protein Serine-Threonine Kinases