title: A red baby should not be taken too lightly.
abstract: OBJECTIVE
  To identify clinical and laboratory features that can drive the differential diagnosis of a primary immunodeficiency diseases in patients with ectodermal defects.
  
  
  METHODS
  Analysis of selected teaching cases.
  
  
  RESULTS
  We identified four exemplary cases that allowed to point out specific clues.
  
  
  CONCLUSIONS
  A careful evaluation of immune and ectodermal signs is the key to the diagnosis. Therefore, a multidisciplinary approach can lead to diagnosis and to an appropriate treatment in most of the cases.
authors.affiliation: Institute for Maternal and Child Health, IRCCS Burlo Garofolo, Trieste, Italy. faletra@burlo.trieste.it
authors.forename: Flavio
authors.initials: F
authors.lastname: Faletra
authors.forename: Irene
authors.initials: I
authors.lastname: Bruno
authors.forename: Irene
authors.initials: I
authors.lastname: Berti
authors.forename: Serena
authors.initials: S
authors.lastname: Pastore
authors.forename: Angela
authors.initials: A
authors.lastname: Pirrone
authors.forename: Alberto
authors.initials: A
authors.lastname: Tommasini
mesh_terms: D002675:Child, Preschool; D003872:Dermatitis / Q000209:etiology*; D004476:Ectodermal Dysplasia / Q000175:diagnosis*; D005260:Female; D006801:Humans; D007153:Immunologic Deficiency Syndromes / Q000150:complications / Q000235:genetics / Q000473:pathology*; D007223:Infant; D008297:Male; D056770:Netherton Syndrome / Q000175:diagnosis*; D016511:Severe Combined Immunodeficiency / Q000175:diagnosis; D012867:Skin / Q000473:pathology*