title: [Nrf2 as a chemoprevention target in gastrointestinal carcinoma].
abstract: Gastrointestinal tract carcinoma is one of the leading causes of cancer-related death in China. Chemoprevention has been considered as a potential approach to control this type of disease. Nuclear factor erythroid 2-related factor 2 (Nrf2) is a redox-sensitive transcription factor that protects cells from oxidative/electrophilic stresses by activating the expression of a battery of cytoprotective genes through the antioxidant response element (ARE). Recently, Nrf2 has emerged as a novel target for chemoprevention. Several natural or synthetic chemicals, which activate Nrf2/ARE signaling pathway, have showed effect in animal models, and promises in many ongoing clinical trials. This review summarizes the recent findings on the regulation of Nrf2/ARE signaling pathway, and the developments in both preclinical and clinical studies.
authors.affiliation: Department of Pharmacology, Zhejiang University School of Medicine, Hangzhou 310058, China.
authors.forename: Peng
authors.initials: P
authors.lastname: Gao
authors.forename: Xiu-wen
authors.initials: XW
authors.lastname: Tang
authors.forename: Xiu-jun
authors.initials: XJ
authors.lastname: Wang
mesh_terms: D000818:Animals; D016588:Anticarcinogenic Agents / Q000494:pharmacology; D000975:Antioxidants / Q000378:metabolism*; D018890:Chemoprevention; D004067:Digestive System Neoplasms / Q000235:genetics / Q000378:metabolism* / Q000517:prevention & control; D006801:Humans; D051267:NF-E2-Related Factor 2 / Q000235:genetics / Q000378:metabolism*; D018384:Oxidative Stress / Q000187:drug effects; D020218:Response Elements / Q000235:genetics; D015398:Signal Transduction / Q000187:drug effects
chemical_list: D016588:Anticarcinogenic Agents; D000975:Antioxidants; D051267:NF-E2-Related Factor 2