title: Aryl-linked imidazolidin-2-ones as non-peptidic β-strand mimetics.
abstract: We describe the design and synthesis of a non-peptidic β-strand mimetic composed of alternating aryl and imidazolidin-2-one rings that can be adapted to display diverse side-chains. Solid- and solution-phase data together with calculations suggest that the desired conformation for side-chain mimicry is readily accessible and well-populated.
authors.affiliation: Department of Chemistry, Chemistry Research Laboratory, University of Oxford, Mansfield Road, Oxford OX1 3TA, UK.
authors.forename: Charlotte L
authors.initials: CL
authors.lastname: Sutherell
authors.forename: Sam
authors.initials: S
authors.lastname: Thompson
authors.forename: Richard T W
authors.initials: RT
authors.lastname: Scott
authors.forename: Andrew D
authors.initials: AD
authors.lastname: Hamilton
mesh_terms: D040761:Biomimetic Materials / Q000138:chemical synthesis / Q000737:chemistry*; D018360:Crystallography, X-Ray; D048289:Imidazolidines / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D008968:Molecular Conformation; D010455:Peptides / Q000737:chemistry; D012996:Solutions / Q000737:chemistry
chemical_list: D048289:Imidazolidines; D010455:Peptides; D012996:Solutions; C004916:ethylene urea