title: [TSG-6 protein and its role during maturation of ovarian follicles].
abstract: TSG-6 is an ~35 kDa glycoprotein belonging to the hyaluronan binding family. Its expression is induced as a result of an inflammatory condition and during ovulation. TSG-6 is a crucial protein engaged in extracellular matrix synthesis and organization of cumulus-oophorus-complexes (COCs) in preovulatory ovarian follicles. TSG-6 catalyzes cross-linking via heavy chains of trypsin α inhibitor and hyaluronan. This reaction is essential for proper cumulus cell expansion. This process is correlated with purchasing competence by the oocyte. Disorders of the synthesis of TSG-6 cause irregularities in expansion of cumulus cells during ovarian follicle maturation. Therefore, TSG-6 is a potential molecular marker of oocyte maturation.
authors.affiliation: Zakład Histologii i Embriologii, Katedra Nauk Morfologicznych, Wydział Medycyny Weterynaryjnej, Szkoła Główna Gospodarstwa Wiejskiego w Warszawie. piotr.z.trzeciak@gmail.com
authors.forename: Piotr
authors.initials: P
authors.lastname: Trzeciak
authors.forename: Łukasz
authors.initials: Ł
authors.lastname: Rąpała
authors.forename: Rafał
authors.initials: R
authors.lastname: Starzyński
authors.forename: Sebastian
authors.initials: S
authors.lastname: Dąbrowski
authors.forename: Anna Maria
authors.initials: AM
authors.lastname: Duszewska
mesh_terms: D015415:Biomarkers / Q000378:metabolism; D015815:Cell Adhesion Molecules / Q000032:analysis / Q000378:metabolism*; D054885:Cumulus Cells / Q000378:metabolism; D005109:Extracellular Matrix / Q000378:metabolism; D005260:Female; D006801:Humans; D006820:Hyaluronic Acid / Q000032:analysis / Q000378:metabolism; D009865:Oocytes / Q000378:metabolism; D006080:Ovarian Follicle / Q000737:chemistry / Q000378:metabolism*; D010060:Ovulation / Q000378:metabolism*
chemical_list: D015415:Biomarkers; D015815:Cell Adhesion Molecules; C072273:TNFAIP6 protein, human; D006820:Hyaluronic Acid