title: Bis(perfluoroalkyl) phosphino-oxazoline: a modular, stable, strongly π-accepting ligand for asymmetric catalysis.
abstract: A new class of stable, strongly π-accepting and modular bis(perfluoroalkyl)-phosphine-oxazoline ligands (FOX) as CO mimics was prepared. It was demonstrated that these ligands, when coordinated to palladium catalysts, promote the asymmetric alkylation of monosubstituted allyl substrates with excellent regio- and enantioselectivity. Solid and solution structure analysis of the FOX-ligated Pd-allyl intermediate reveals that the combination of relative steric and strong trans influences presented by the P(CF(3))(2) moiety gave rise to the excellent selectivity.
authors.affiliation: Key Laboratory of Organofluorine Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Road, Shanghai 200032, People's Republic of China.
authors.forename: Zongjian
authors.initials: Z
authors.lastname: Hu
authors.forename: Yuguang
authors.initials: Y
authors.lastname: Li
authors.forename: Kai
authors.initials: K
authors.lastname: Liu
authors.forename: Qilong
authors.initials: Q
authors.lastname: Shen
mesh_terms: D000498:Allyl Compounds / Q000737:chemistry*; D002384:Catalysis; D005466:Fluorocarbons / Q000737:chemistry*; D008024:Ligands; D015394:Molecular Structure; D010080:Oxazoles / Q000737:chemistry*; D010165:Palladium / Q000737:chemistry*; D012996:Solutions; D013237:Stereoisomerism
chemical_list: D000498:Allyl Compounds; D005466:Fluorocarbons; D008024:Ligands; D010080:Oxazoles; D012996:Solutions; D010165:Palladium