title: Symptomatic improvement of diffuse esophageal spasm after botulinum toxin injection.
abstract: Diffuse esophageal spasm, an uncommon esophageal motility disorder, has recently been defined using high-resolution manometry. Patients with distal esophageal spasm usually complain of chest pain or dysphagia. The etiology and pathophysiology of this disorder are poorly known, and treatment options are limited. However, some options to improve symptoms are available, including endoscopic injection of botulinum toxin. Nevertheless, few reports have described the effects of endoscopic injection of botulinum toxin in patients with symptomatic diffuse esophageal spasm with clear endoscopic and high-resolution manometry images. Here, we report a case of diffuse esophageal spasm diagnosed with high-resolution manometry and treated by endoscopic injection of botulinum toxin with good results at the 7-month follow-up.
authors.affiliation: Department of Internal Medicine, Bucheon Hospital, Soonchunhyang University College of Medicine, 170 Jomaru-ro, Wonmi-gu, Bucheon 420-767, Korea.
authors.forename: Jae Pil
authors.initials: JP
authors.lastname: Han
authors.forename: Su Jin
authors.initials: SJ
authors.lastname: Hong
authors.forename: Hoon Il
authors.initials: HI
authors.lastname: Kim
authors.forename: Jin Myung
authors.initials: JM
authors.lastname: Byun
authors.forename: Hwa Jong
authors.initials: HJ
authors.lastname: Kim
authors.forename: Bong Min
authors.initials: BM
authors.lastname: Ko
authors.forename: Joon Seong
authors.initials: JS
authors.lastname: Lee
authors.forename: Moon Sung
authors.initials: MS
authors.lastname: Lee
mesh_terms: D000368:Aged; D018726:Anti-Dyskinesia Agents / Q000627:therapeutic use*; D001905:Botulinum Toxins / Q000627:therapeutic use*; D016145:Endoscopy, Digestive System; D015155:Esophageal Spasm, Diffuse / Q000000981:diagnostic imaging / Q000628:therapy*; D005260:Female; D006801:Humans; D008365:Manometry; D014057:Tomography, X-Ray Computed
chemical_list: D018726:Anti-Dyskinesia Agents; D001905:Botulinum Toxins