title: Natural products as a rich source of tau-targeting drugs for Alzheimer's disease.
abstract: Alzheimer's disease (AD) is a neurodegenerative disorder and the most common form of dementia, affecting more than 5.4 million people in the USA. Although the cause of AD is not well understood, the cholinergic, amyloid and tau hypotheses were proposed to explain its development. Drug discovery for AD based on the cholinergic and amyloid theories have not been effective. In this article we summarize tau-based natural products as AD therapeutics from a variety of biological sources, including the anti-amyloid agent curcumin, isolated from turmeric, the microtubule stabilizer paclitaxel, from the Pacific Yew Taxus brevifolia, and the Streptomyces-derived Hsp90 inhibitor, geldanamycin. The overlooked approach of clearing tau aggregation will most likely be the next objective for AD drug discovery.
authors.affiliation: Department of Chemistry & Center for Drug Discovery & Innovation, University of South Florida, FL, USA.
authors.forename: Laurent
authors.initials: L
authors.lastname: Calcul
authors.forename: Bo
authors.initials: B
authors.lastname: Zhang
authors.forename: Umesh K
authors.initials: UK
authors.lastname: Jinwal
authors.forename: Chad A
authors.initials: CA
authors.lastname: Dickey
authors.forename: Bill J
authors.initials: BJ
authors.lastname: Baker
mesh_terms: D000544:Alzheimer Disease / Q000188:drug therapy* / Q000378:metabolism*; D000818:Animals; D001688:Biological Products / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D055808:Drug Discovery / Q000379:methods*; D006801:Humans; D016875:tau Proteins / Q000378:metabolism*
chemical_list: D001688:Biological Products; D016875:tau Proteins