title: Fast Pd- and Pd/Cu-catalyzed direct C-H arylation of cyclic nitrones. Application to the synthesis of enantiopure quaternary α-amino esters.
abstract: Cocatalysis by pivalic acid or copper bromide allows a very fast, clean, and high-yielding palladium-catalyzed coupling of a large array of aryl, thienyl, and pyridyl halides with cyclic nitrones, including DMPO. The study of the reaction conditions, scope, and mechanism is presented. Applied to the chiral nitrone MiPNO, this transformation provides a straightforward access to enantiopure α-methyl α-arylglycine esters.
authors.affiliation: Département de Chimie Moléculaire, Equipe SeRCO and ‡Service de Cristallographie, UMR-5250, ICMG FR-2607, CNRS, Université Joseph Fourier, BP-53, 38041 Grenoble Cedex 9, France.
authors.forename: Emilien
authors.initials: E
authors.lastname: Demory
authors.forename: Daniel
authors.initials: D
authors.lastname: Farran
authors.forename: Benoit
authors.initials: B
authors.lastname: Baptiste
authors.forename: Pierre Y
authors.initials: PY
authors.lastname: Chavant
authors.forename: Véronique
authors.initials: V
authors.lastname: Blandin