title: Antiviral chlorinated daphnane diterpenoid orthoesters from the bark and wood of Trigonostemon cherrieri.
abstract: The chemical study of the bark and the wood of Trigonostemon cherrieri, a rare endemic plant of New Caledonia, led to the isolation of a series of highly oxygenated daphnane diterpenoid orthoesters (DDO) bearing an uncommon chlorinated moiety: trigocherrins A-F and trigocherriolides A-D. Herein, we describe the isolation and structure elucidation of the DDO (trigocherrins B-F and trigocherriolides A-D). We also report the antiviral activity of trigocherrins A, B and F (1, 2 and 6) and trigocherriolides A, B and C (7-9) against various emerging pathogens: chikungunya virus (CHIKV), Sindbis virus (SINV), Semliki forest virus (SFV) and dengue virus (DENV).
authors.affiliation: Centre de Recherche de Gif, Institut de Chimie des Substances Naturelles, CNRS, LabEx LERMIT, 1 Avenue de la Terrasse, 91198 Gif-sur-Yvette Cedex, France.
authors.forename: Pierre-Marie
authors.initials: PM
authors.lastname: Allard
authors.forename: Pieter
authors.initials: P
authors.lastname: Leyssen
authors.forename: Marie-Thérèse
authors.initials: MT
authors.lastname: Martin
authors.forename: Mélanie
authors.initials: M
authors.lastname: Bourjot
authors.forename: Vincent
authors.initials: V
authors.lastname: Dumontet
authors.forename: Cécilia
authors.initials: C
authors.lastname: Eydoux
authors.forename: Jean-Claude
authors.initials: JC
authors.lastname: Guillemot
authors.forename: Bruno
authors.initials: B
authors.lastname: Canard
authors.forename: Cyril
authors.initials: C
authors.lastname: Poullain
authors.forename: Françoise
authors.initials: F
authors.lastname: Guéritte
authors.forename: Marc
authors.initials: M
authors.lastname: Litaudon
mesh_terms: D000998:Antiviral Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D002646:Chikungunya virus / Q000187:drug effects*; D003716:Dengue Virus / Q000187:drug effects*; D004224:Diterpenes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D004952:Esters / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D019665:Euphorbiaceae / Q000737:chemistry*; D008826:Microbial Sensitivity Tests; D008968:Molecular Conformation; D024301:Plant Bark / Q000737:chemistry; D012672:Semliki forest virus / Q000187:drug effects*; D012845:Sindbis Virus / Q000187:drug effects*; D014934:Wood / Q000737:chemistry
chemical_list: D000998:Antiviral Agents; D004224:Diterpenes; D004952:Esters