title: Antibody-independent thrombocytopenia in lactate dehydrogenase-elevating virus-infected mice.
abstract: Previously we demonstrated that antibody-mediated thrombocytopenia is strongly enhanced by lactate dehydrogenase-elevating virus (LDV) infection. Here we report that mice infected with LDV develop a moderate thrombocytopenia, even in the absence of immunoglobulins or Fc receptors. A similar decrease of platelet counts was observed after mouse hepatitis virus infection. LDV-induced type I interferon-independent thrombocytopenia was partly suppressed by treatment with clodronate-containing liposomes. Therefore, we conclude that the thrombocytopenia results from increased phagocytosis of nonopsonized platelets by macrophages.
authors.affiliation: Unit of Experimental Medicine, de Duve Institute, Université Catholique de Louvain, Brussels, Belgium.
authors.forename: Dan
authors.initials: D
authors.lastname: Su
authors.forename: Andrei
authors.initials: A
authors.lastname: Musaji
authors.forename: Sarah
authors.initials: S
authors.lastname: Legrain
authors.forename: Laurent
authors.initials: L
authors.lastname: Detalle
authors.forename: Jos
authors.initials: J
authors.lastname: van der Kaa
authors.forename: J Sjef
authors.initials: JS
authors.lastname: Verbeek
authors.forename: Bernhard
authors.initials: B
authors.lastname: Ryffel
authors.forename: Jean-Paul
authors.initials: JP
authors.lastname: Coutelier
mesh_terms: D000818:Animals; D018174:Arterivirus Infections / Q000821:virology*; D001792:Blood Platelets / Q000821:virology; D004002:Clodronic Acid / Q000494:pharmacology; D005260:Female; D007136:Immunoglobulins / Q000378:metabolism; D007772:Lactate dehydrogenase-elevating virus / Q000378:metabolism*; D008081:Liposomes / Q000737:chemistry; D008264:Macrophages / Q000821:virology; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D010587:Phagocytosis; D010976:Platelet Count; D011961:Receptors, Fc / Q000378:metabolism; D013921:Thrombocytopenia / Q000276:immunology*; D014779:Virus Replication
chemical_list: D007136:Immunoglobulins; D008081:Liposomes; D011961:Receptors, Fc; D004002:Clodronic Acid