title: Microbial metabolism. Part 14. Isolation and bioactivity evaluation of microbial metabolites of resveratrol.
abstract: The fungi, Beauveria bassiana (ATCC 13144) and Penicillium chrysogenium (ATCC 9480) transformed resveratrol to resveratrol-3-O-sulphate. The former, in addition, gave 5-methoxyresveratrol-3-O-β-glucoside with the latter yielding 5-methoxyresveratrol-3-O-sulphate. The structures were established by spectroscopic methods. Evaluation of biological activity of metabolites through a series of mammalian cell based assays indicated that resveratrol tends to lose its anti-inflammatory, cytotoxic and anti-oxidant activities with the substitution of its hydroxyl groups.
authors.affiliation: a National Center for Natural Products Research, Research Institute of Pharmaceutical Sciences, School of Pharmacy, The University of Mississippi , University , MS 38677 , USA.
authors.forename: Wimal
authors.initials: W
authors.lastname: Herath
authors.forename: Shabana Iqrar
authors.initials: SI
authors.lastname: Khan
authors.forename: Ikhlas Ahmad
authors.initials: IA
authors.lastname: Khan
mesh_terms: D052982:Beauveria / Q000378:metabolism; D005960:Glucosides / Q000737:chemistry / Q000378:metabolism; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D010408:Penicillium chrysogenum / Q000378:metabolism; D000077185:Resveratrol; D013267:Stilbenes / Q000737:chemistry* / Q000378:metabolism*
chemical_list: D005960:Glucosides; D013267:Stilbenes; D000077185:Resveratrol