title: Extra-pulmonary tuberculosis developing at sites of previous trauma.
abstract: We describe five individuals in whom extra-pulmonary tuberculosis appeared to localise at a site of previous blunt injury. We review other similar case reports where preceding trauma was blunt and non-penetrating, and discuss a possible mechanism involving transport of mycobacteria in monocytes to sites of injury during "latent" tuberculosis infection. This challenges the conventional model proposed for mycobacteria dissemination in tuberculosis disease.
authors.affiliation: Dept. Infectious Diseases and Tropical Medicine, Northwick Park Hospital, 1053 Great Western Road, Harrow HA1 3UJ, UK. davidadambarr@hotmail.com
authors.forename: David A
authors.initials: DA
authors.lastname: Barr
authors.forename: Ashley M
authors.initials: AM
authors.lastname: Whittington
authors.forename: Beth
authors.initials: B
authors.lastname: White
authors.forename: Benjamin
authors.initials: B
authors.lastname: Patterson
authors.forename: Robert N
authors.initials: RN
authors.lastname: Davidson
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D055985:Latent Tuberculosis / Q000453:epidemiology* / Q000382:microbiology / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D009000:Monocytes / Q000382:microbiology; D009169:Mycobacterium tuberculosis / Q000472:pathogenicity*; D014949:Wounds, Nonpenetrating / Q000150:complications*; D055815:Young Adult