title: Expression of calcium binding protein S100 A7 (psoriasin) in laryngeal carcinoma.
abstract: Many studies have reported increased expression of S100 A7 (psoriasin) in neoplastic lesions. Among them are studies on breast carcinoma, bladder squamous cell carcinoma, skin tumors and oral cavity squamous cell carcinoma. The expression of S100 A7 has not been described for laryngeal cancer.
  
  
  OBJECTIVE
  This study aims to identify the expression of the calcium-binding protein S100 A7 and its correlation with squamous cell carcinomas of the larynx.
  
  
  METHODS
  Specimens from 63 patients were submitted to immunohistochemistry testing with antibody S100 A7. Results were classified and compared.
  
  
  RESULTS
  The group with highly differentiated tumors had the highest treatment failure scores. Moderately differentiated tumors had higher treatment failure scores than poorly differentiated tumors. Higher scores were predominantly seen on stages I and II in moderately differentiated tumors, whereas score distribution was more homogeneous in advanced stage disease (III and IV). Regarding failure in treatment, the group scoring zero (3/4 complications: 75%) differed significantly from the remaining groups (13/59: 22%).
  
  
  CONCLUSIONS
  S100 A7 marker was expressed in 93.7% of laryngeal cancer cases, with higher positive correlation rates in more differentiated tumors and significantly lower rates of treatment failure. Scores had no impact on survival rates.
authors.affiliation: Departamento de Oftalmologia, Otorrinolaringologia e Cirurgia de Cabeça e Pescoço, Escola de Medicina de Ribeirão Preto, Universidade de São Paulo, Brasil.
authors.forename: Rogério Costa
authors.initials: RC
authors.lastname: Tiveron
authors.forename: Luiz Carlos Conti
authors.initials: LC
authors.lastname: de Freitas
authors.forename: David L
authors.initials: DL
authors.lastname: Figueiredo
authors.forename: Luciano N
authors.initials: LN
authors.lastname: Serafini
authors.forename: Rui Celso Martins
authors.initials: RC
authors.lastname: Mamede
authors.forename: Marco A
authors.initials: MA
authors.lastname: Zago
mesh_terms: D000328:Adult; D000368:Aged; D014408:Biomarkers, Tumor / Q000032:analysis / Q000378:metabolism; D002294:Carcinoma, Squamous Cell / Q000378:metabolism* / Q000401:mortality / Q000473:pathology; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D007822:Laryngeal Neoplasms / Q000378:metabolism* / Q000401:mortality / Q000473:pathology; D008875:Middle Aged; D009363:Neoplasm Proteins / Q000032:analysis / Q000378:metabolism*; D009364:Neoplasm Recurrence, Local; D009367:Neoplasm Staging; D000075023:S100 Calcium Binding Protein A7; D009418:S100 Proteins / Q000032:analysis / Q000378:metabolism*; D016019:Survival Analysis
chemical_list: D014408:Biomarkers, Tumor; D009363:Neoplasm Proteins; D000075023:S100 Calcium Binding Protein A7; D009418:S100 Proteins; C089242:S100A7 protein, human