title: Point-to-helical chirality transfer for a scalable and resolution-free synthesis of a helicenoidal DMAP organocatalyst.
abstract: The synthesis of a second-generation [6]-helicenoidal DMAP organocatalyst is reported. The synthesis is reliant upon a highly diastereoselective Rh-catalysed [2 + 2 + 2] triyne cycloisomerization, using an existing stereocentre to control the sense of forming helicity. Taken together, a scalable (>1 g), resolution-free entry to a helical DMAP with the capacity for subsequent functionalization, has been achieved.
authors.affiliation: Department of Chemistry, University of Bath, Claverton Down, UK.
authors.forename: Matthew R
authors.initials: MR
authors.lastname: Crittall
authors.forename: Nathan W G
authors.initials: NW
authors.lastname: Fairhurst
authors.forename: David R
authors.initials: DR
authors.lastname: Carbery