title: Effect of dietary sunflower oil and coconut oil on adipose tissue gene expression, fatty acid composition and serum lipid profile of grower pigs.
abstract: The present study was conducted to assess whether the partial replacement of feed energy by vegetable oils containing high medium-chain saturated fatty acids (MCFA) and n-6 polyunsaturated fatty acids (PUFA) would modify lipogenic gene expression and other parameter of fat metabolism in pigs. Eighteen pigs (17-19 kg body weight) received one of three experimental diets for 60 days (six animals per group): (i) Control diet; (ii) a diet with sunflower oil (SO) or (iii) a diet with coconut oil (CO). In diets SO and CO, 10% of the feed energy was replaced by the respective oils. The experimental treatment did not influence the performance of the pigs. In blood serum, an increased content of total cholesterol was observed for SO and CO fed animals, whereas no significant changes for total triglycerides and different lipoprotein fractions were detected. The fatty acid composition of adipose tissue was significantly modified, with an increased content of MCFA and n-6 PUFA in CO and SO fed pigs, respectively. The gene expression for fatty acid synthase was decreased for SO and CO fed pigs; for stearoyl CoA desaturase and sterol regulatory element binding protein, a depression was observed in SO but not in CO fed pigs. The results of present study suggest that the type of dietary fat can modulate the adipose tissue gene expression and fatty acid composition differentially, with minimal effect on serum lipid profile.
authors.affiliation: National Research Centre on Pig, Guwahati, Assam, India. mohannh.icar@nic.in
authors.forename: Mohan N Harihara
authors.initials: MN
authors.lastname: Iyer
authors.forename: Babul C
authors.initials: BC
authors.lastname: Sarmah
authors.forename: Madan K
authors.initials: MK
authors.lastname: Tamuli
authors.forename: Anubrata
authors.initials: A
authors.lastname: Das
authors.forename: Dhireswar
authors.initials: D
authors.lastname: Kalita
mesh_terms: D000273:Adipose Tissue / Q000187:drug effects / Q000378:metabolism*; D000821:Animal Feed / Q000032:analysis; D000824:Animal Nutritional Physiological Phenomena; D000818:Animals; D000074263:Coconut Oil; D004032:Diet / Q000662:veterinary; D005227:Fatty Acids / Q000378:metabolism*; D005786:Gene Expression Regulation / Q000187:drug effects; D008055:Lipids / Q000097:blood*; D008297:Male; D010938:Plant Oils / Q000737:chemistry / Q000494:pharmacology*; D000074242:Sunflower Oil; D013552:Swine / Q000254:growth & development* / Q000378:metabolism*
chemical_list: D005227:Fatty Acids; D008055:Lipids; D010938:Plant Oils; D000074242:Sunflower Oil; D000074263:Coconut Oil