title: Dancing partners at the synapse: auxiliary subunits that shape kainate receptor function.
abstract: Kainate receptors are a family of ionotropic glutamate receptors whose physiological roles differ from those of other subtypes of glutamate receptors in that they predominantly serve as modulators, rather than mediators, of synaptic transmission. Neuronal kainate receptors exhibit unusually slow kinetic properties that have been difficult to reconcile with the behaviour of recombinant kainate receptors. Recently, however, the neuropilin and tolloid-like 1 (NETO1) and NETO2 proteins were identified as auxiliary kainate receptor subunits that shape both the biophysical properties and synaptic localization of these receptors.
authors.affiliation: Department of Molecular Pharmacology and Biological Chemistry, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, USA.
authors.forename: Bryan A
authors.initials: BA
authors.lastname: Copits
authors.forename: Geoffrey T
authors.initials: GT
authors.lastname: Swanson
mesh_terms: D000818:Animals; D018390:Gene Targeting / Q000379:methods; D006801:Humans; D008565:Membrane Proteins / Q000502:physiology*; D021122:Protein Subunits / Q000502:physiology*; D018092:Kainic Acid Receptors / Q000502:physiology*; D016194:Receptors, N-Methyl-D-Aspartate; D013569:Synapses / Q000502:physiology*
chemical_list: D008565:Membrane Proteins; D021122:Protein Subunits; D018092:Kainic Acid Receptors; D016194:Receptors, N-Methyl-D-Aspartate; C456602:NETO1 protein, human