title: Anti-nociceptive and anti-inflammatory activities of Azadirachta indica fruit skin extract and its isolated constituent azadiradione.
abstract: This study was carried out to evaluate the anti-nociceptive and anti-inflammatory activities of carbon tetrachloride extract (CTCE) of Azadirachta indica fruit skin and its isolated constituent azadiradione at two different dose levels (50 and 100 mg kg⁻¹ body weight). Anti-nociceptive screening by writhing test and hot-plate technique supported both peripheral and central mechanisms, respectively. Anti-inflammatory activity was observed using carrageenan-induced paw oedema model. The results concluded that the animals treated with 100 mg kg⁻¹ dose of CTCE and azadiradione exhibited significant anti-nociceptive and anti-inflammatory activities. This study had rationalised the ethnomedicinal use of the plant for wound, burns and injury by tribal people.
authors.affiliation: a Department of Pharmaceutical Chemistry , College of Pharmacy, S.R.M. University , Kattankulathur - 603 203 , Tamil Nadu , India.
authors.forename: K
authors.initials: K
authors.lastname: Ilango
authors.forename: G
authors.initials: G
authors.lastname: Maharajan
authors.forename: S
authors.initials: S
authors.lastname: Narasimhan
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000737:chemistry* / Q000627:therapeutic use*; D031601:Azadirachta / Q000737:chemistry*; D002251:Carbon Tetrachloride / Q000737:chemistry; D002351:Carrageenan / Q000633:toxicity; D004487:Edema / Q000139:chemically induced / Q000188:drug therapy*; D005638:Fruit / Q000737:chemistry*; D036701:Limonins / Q000737:chemistry* / Q000627:therapeutic use; D051379:Mice; D010936:Plant Extracts / Q000737:chemistry* / Q000627:therapeutic use*
chemical_list: D000893:Anti-Inflammatory Agents; D036701:Limonins; D010936:Plant Extracts; C479321:azadiradione; D002351:Carrageenan; D002251:Carbon Tetrachloride