title: Bone metabolism and clinical study of 44 patients with  bisphosphonate-related osteonecrosis of the jaws.
abstract: Osteonecrosis of the jaws is a clinical entity described and linked to treatment with bisphosphonates in 2003. Its real incidence is unknown and it could increase due to the large number of patients treated with these drugs, and its cumulative effect on the bone. State of the art knowledge regarding its etiopathogeny, clinical course and suitable treatments is limited.
  
  
  OBJECTIVE
  To study the clinical characteristics of 44 patients with bisphosphonate-related osteonecrosis of the jaws and the state of their bone mineral metabolism: bone remodeling state, prevalence of fractures, bone mineral density study, and assessment of the different treatment strategies.
  
  
  METHODS
  Observational. Information was gathered prospectively through interviews, clinical examinations, additional tests and review of medical records.
  
  
  RESULTS
  We studied 16 men and 28 women with a mean age of 64.7 years. Breast cancer was the most frequent underlying disease. Zoledronate was used in 82% of the cases and in the non-oncology group of patients; alendronate was the most frequently used bisphosphonate. The mean duration of the zoledronate and alendronate treatments was 25 months and 88 months respectively. The lower jaw was the most frequent location, and previous exodontias-among the triggering factors known-were the most closely linked to its onset. We found considerable osteoblastic activity in patients suffering from neoplasia, with artifacts present in their bone densitometry and a high percentage of vertebral fractures.
  
  
  CONCLUSIONS
  According to our results, osteonecrosis of the jaws affects elderly patients. We found a direct relationship between the duration of exposure and the accumulated dose. Other relevant factors are: Poor oral and dental health, corticoids, diabetes and teeth extractions. In essence, it is a clinical diagnosis. Prevention is the best strategy to handle this clinical entity.
authors.affiliation: Insular Maternal and Child University Hospital Complex of Las Palmas of Gran Canaria, Stomatology Department, Bone Metabolism Unit and Research Unit, Las Palmas of Gran Canaria, Spain.
authors.forename: María-Sacramento
authors.initials: MS
authors.lastname: Bocanegra-Pérez
authors.forename: Mario
authors.initials: M
authors.lastname: Vicente-Barrero
authors.forename: Manuel
authors.initials: M
authors.lastname: Sosa-Henríquez
authors.forename: Eduardo
authors.initials: E
authors.lastname: Rodríguez-Bocanegra
authors.forename: José-María
authors.initials: JM
authors.lastname: Limiñana-Cañal
authors.forename: Ariadna
authors.initials: A
authors.lastname: López-Márquez
authors.forename: Daniel
authors.initials: D
authors.lastname: Pérez-Plasencia
authors.forename: Angel
authors.initials: A
authors.lastname: Ramos-Macías
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D059266:Bisphosphonate-Associated Osteonecrosis of the Jaw / Q000378:metabolism*; D001842:Bone and Bones / Q000378:metabolism*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies