title: Systemic oxidative stress in older patients with mild cognitive impairment or late onset Alzheimer's disease.
abstract: A large body of evidences obtained in human and animal brain tissue suggest a role of oxidative stress (OxS) in the pathogenesis of late onset Alzheimer's disease (LOAD); on the contrary, data on peripheral markers of OxS in LOAD are still controversial. We evaluated the serum levels of products of lipid peroxidation, hydroperoxides, advanced oxidation protein products, total and residual antioxidant power, thiols, and uric acid in a sample of 334 older individuals: 101 LOAD patients, 134 patients with mild cognitive impairment (MCI), and 99 controls. At univariate analysis, serum hydroperoxides were higher while residual antioxidant power was lower in MCI and LOAD compared with in controls. By multivariate logistic regression analysis we found that, compared with controls, high levels (over median value) of serum hydroperoxides were independently associated with an increase in the likehood of having MCI (Odd Ratio: 2.59, 95% Confidence Interval: 1.08-6.21) or LOAD (OR: 4.09, 95%CI: 1.36-11.81). Furthermore, low levels of residual antioxidant power (below the median value) were associated with increased risk of having MCI (OR: 3.97, 95% CI: 1.62-9.72), but not dementia (OR: 2.31, 95%CI: 0.83-6.63). Our study suggests that a systemic redox-imbalance leading to OxS might be associated not only with LOAD but also with MCI.
authors.affiliation: Department of Clinical and Experimental Medicine, Section of Internal Medicine, Gerontology, and Clinical Nutrition, University of Ferrara, Via Savonarola n°9, 44100 Italy.
authors.forename: Carlo
authors.initials: C
authors.lastname: Cervellati
authors.forename: Eleonora
authors.initials: E
authors.lastname: Cremonini
authors.forename: Cristina
authors.initials: C
authors.lastname: Bosi
authors.forename: Stefania
authors.initials: S
authors.lastname: Magon
authors.forename: Amedeo
authors.initials: A
authors.lastname: Zurlo
authors.forename: Carlo M
authors.initials: CM
authors.lastname: Bergamini
authors.forename: Giovanni
authors.initials: G
authors.lastname: Zuliani
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000375:Aging; D000544:Alzheimer Disease / Q000175:diagnosis / Q000378:metabolism*; D000704:Analysis of Variance; D000975:Antioxidants / Q000378:metabolism; D001921:Brain / Q000000981:diagnostic imaging / Q000473:pathology; D060825:Cognitive Dysfunction / Q000378:metabolism* / Q000473:pathology; D005260:Female; D006801:Humans; D015227:Lipid Peroxidation / Q000502:physiology; D008054:Lipid Peroxides / Q000378:metabolism; D008297:Male; D008609:Mental Status Schedule; D008875:Middle Aged; D018384:Oxidative Stress / Q000502:physiology*; D012189:Retrospective Studies; D014057:Tomography, X-Ray Computed
chemical_list: D000975:Antioxidants; D008054:Lipid Peroxides