title: Use of 2-octyl cyanoacrylate adhesive in rat liver induced lesion.
abstract: OBJECTIVE
  To evaluate the healing process of rat traumatic liver lesion corrected with the use of 2-octyl cyanoacrylate adhesive, compared to the use of biologically absorbable chromed catgut thread suture.
  
  
  METHODS
  Thirty mail adult rats were divided into two groups (15 per group) according to the used method for liver lesion correction as follows: adhesive group (AG), and catgut group (CG); each group being divided into three subsets of five animals (7th, 14th, and 21st day), respectively, according to post-surgery evaluation. All animals were submitted to homogeneous lesion applying synthetic bonding to AG and using chromed catgut suture to CG for lesion correction. Macroscopic and microscopic parameters of healing processes were evaluated.
  
  
  RESULTS
  Both groups of animals showed excellent abdominal wall healing, with no evidence of infection, and no abdominal cavity peritonitis or abscess. The presence of adherence was observed in both groups with no statistically significant difference. As to macroscopic evaluation, there was statistically significant difference with respect to specific factors of clinical inflammation (ischemic inflammation and giant celular inflammatory reaction) between animals evaluated on the 10th day (ischemic necrosis and giant cellular inflammatory reaction) among animals evaluated on the 14th day (A14 versus C14).
  
  
  CONCLUSIONS
  Applying 2-octyl-cyanoacrylate adhesive for correcting rat liver lesion does not change healing process when compared to the use of chromed catgut stitch.
authors.affiliation: Department of Medicine II, UFMA, Sao Luis-MA, Brazil. orlanddojs@hotmail.com
authors.forename: Orlando José dos
authors.initials: OJ
authors.lastname: Santos
authors.forename: Giancarlo de Souza
authors.initials: Gde S
authors.lastname: Marques
authors.forename: Euler Nicolau
authors.initials: EN
authors.lastname: Sauaia Filho
authors.forename: Gustavo Medeiros
authors.initials: GM
authors.lastname: Frota
authors.forename: Rayan Haquim Pinheiro
authors.initials: RH
authors.lastname: Santos
authors.forename: Rennan Abud Pinheiro
authors.initials: RA
authors.lastname: Santos
mesh_terms: D034861:Abdominal Wall / Q000601:surgery*; D000269:Adhesives / Q000008:administration & dosage*; D000818:Animals; D002398:Catgut; D003487:Cyanoacrylates / Q000008:administration & dosage*; D008099:Liver / Q000601:surgery; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D013536:Suture Techniques
chemical_list: D000269:Adhesives; D003487:Cyanoacrylates; C100832:octyl 2-cyanoacrylate