title: [Severe contact lens-associated fungal keratitis].
abstract: A 23-year-old man presented with severe contact lens-associated keratitis and descemetocele with pre-existing drug therapy. After 1 week of intensive antibiotic treatment Aspergillus fumigatus was identified. Despite adjusted antimycotic treatment a corneal perforation occurred. Due to peripheral scleral infiltration the cornea was primarily closed with a double layer amniotic membrane in order to avoid a sclerokeratoplasty with a bad prognosis. After 2 weeks the peripheral corneal situation stabilized and a simple keratoplasty á chaud could be performed. After surgery and adjusted drug therapy, no adequate signs of recovery occured. In repeated microbiological testing an additional Candida albicans infection was diagnosed and therapy was readjusted. This resulted in a cure of the corneal infection. After 5 years and a re-keratoplasty the patient presented with a clear corneal transplant and a corrected visual acuity of 20/25.
authors.affiliation: Augenklinik, Universitätsklinikum Hamburg Eppendorf, Gebäude W40, Martinistr. 52, 20246, Hamburg, Deutschland. m.eddy@uke.de
authors.forename: M-T
authors.initials: MT
authors.lastname: Eddy
authors.forename: J
authors.initials: J
authors.lastname: Steinberg
authors.forename: G
authors.initials: G
authors.lastname: Richard
authors.forename: A
authors.initials: A
authors.lastname: Hassenstein
mesh_terms: D000935:Antifungal Agents / Q000627:therapeutic use; D001228:Aspergillosis / Q000175:diagnosis / Q000382:microbiology / Q000628:therapy*; D002177:Candidiasis / Q000175:diagnosis / Q000382:microbiology / Q000628:therapy*; D003131:Combined Modality Therapy; D003261:Contact Lenses / Q000009:adverse effects* / Q000382:microbiology; D016039:Corneal Transplantation / Q000379:methods; D015821:Eye Infections, Fungal / Q000175:diagnosis / Q000382:microbiology* / Q000628:therapy*; D006801:Humans; D007634:Keratitis / Q000175:diagnosis / Q000382:microbiology* / Q000628:therapy*; D008297:Male; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D000935:Antifungal Agents