title: [Implication of bone marrow microenvironment in pathogenesis of multiple myeloma].
abstract: Multiple myeloma is a hematooncological disease characterized by malignant proliferation of plasma cells. These cells accumulate in the bone marrow where they suppress physiological hematopoiesis; at the same time, these cells interact with a wide variety of cytokines, growth factors and adhesion molecules. It is obvious that the bone marrow microenvironment plays an important role in disease pathogenesis as well as treatment resistance.
authors.affiliation: Babakova myelomova supina, Ustav patologicke fyziologie, Brno.
authors.forename: B
authors.initials: B
authors.lastname: Fišerová
authors.forename: L
authors.initials: L
authors.lastname: Kubiczková
authors.forename: S
authors.initials: S
authors.lastname: Sevčíková
authors.forename: R
authors.initials: R
authors.lastname: Hájek
mesh_terms: D001853:Bone Marrow / Q000503:physiopathology*; D015815:Cell Adhesion Molecules / Q000502:physiology; D016207:Cytokines / Q000502:physiology; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins / Q000502:physiology; D009101:Multiple Myeloma / Q000503:physiopathology*; D010950:Plasma Cells / Q000502:physiology
chemical_list: D015815:Cell Adhesion Molecules; D016207:Cytokines; D036341:Intercellular Signaling Peptides and Proteins