title: Balsamic Vinegar Improves High Fat-Induced Beta Cell Dysfunction via Beta Cell ABCA1.
abstract: BACKGROUND
  The aim of this study was to investigate the effects of balsamic vinegar on β-cell dysfunction.
  
  
  METHODS
  In this study, 28-week-old Otsuka Long-Evans Tokushima Fatty (OLETF) rats were fed a normal chow diet or a high-fat diet (HFD) and were provided with tap water or dilute balsamic vinegar for 4 weeks. Oral glucose tolerance tests and histopathological analyses were performed thereafter.
  
  
  RESULTS
  In rats fed both the both chow diet and the HFD, the rats given balsamic vinegar showed increased insulin staining in islets compared with tap water administered rats. Balsamic vinegar administration also increased β-cell ATP-binding cassette transporter subfamily A member 1 (ABCA1) expression in islets and decreased cholesterol levels.
  
  
  CONCLUSIONS
  These findings provide the first evidence for an anti-diabetic effect of balsamic vinegar through improvement of β-cell function via increasing β-cell ABCA1 expression.
authors.affiliation: Division of Endocrinology and Metabolism, Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea.
authors.forename: Hannah
authors.initials: H
authors.lastname: Seok
authors.forename: Ji Young
authors.initials: JY
authors.lastname: Lee
authors.forename: Eun Mi
authors.initials: EM
authors.lastname: Park
authors.forename: Se Eun
authors.initials: SE
authors.lastname: Park
authors.forename: Jae Hyuk
authors.initials: JH
authors.lastname: Lee
authors.forename: Seungtaek
authors.initials: S
authors.lastname: Lim
authors.forename: Byung-Wan
authors.initials: BW
authors.lastname: Lee
authors.forename: Eun Seok
authors.initials: ES
authors.lastname: Kang
authors.forename: Hyun Chul
authors.initials: HC
authors.lastname: Lee
authors.forename: Bong Soo
authors.initials: BS
authors.lastname: Cha