title: Treatment of limbic encephalitis with anti-glioma-inactivated 1 (LGI1) antibodies.
abstract: We report a 72-year-old patient who developed acute limbic encephalitis initially considered of uncertain aetiology. Detailed information on clinical presentation, MRI appearance, antibody levels, cognitive impairment assessment, treatment and evolution of the patient is reported here. Since the early 2000s, many antibodies implied in central nervous system autoimmune disorders have been identified. Anti-glioma-inactivated 1 (LGI1) antibodies have been recently identified as associated with limbic encephalitis, as was the case in our patient.
authors.affiliation: Department of Internal Medicine, CHU de Bicetre, 78, rue du Général Leclerc, 94275 Kremlin-Bicetre, France. evguenia.krastinova@bct.aphp.fr
authors.forename: E
authors.initials: E
authors.lastname: Krastinova
authors.forename: M
authors.initials: M
authors.lastname: Vigneron
authors.forename: P
authors.initials: P
authors.lastname: Le Bras
authors.forename: J
authors.initials: J
authors.lastname: Gasnault
authors.forename: C
authors.initials: C
authors.lastname: Goujard
mesh_terms: D000368:Aged; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D000906:Antibodies / Q000627:therapeutic use*; D001932:Brain Neoplasms / Q000276:immunology*; D003072:Cognition Disorders / Q000209:etiology / Q000523:psychology; D004569:Electroencephalography; D005910:Glioma / Q000276:immunology*; D006801:Humans; D016756:Immunoglobulins, Intravenous / Q000627:therapeutic use; D007167:Immunotherapy / Q000379:methods*; D047908:Intracellular Signaling Peptides and Proteins; D020363:Limbic Encephalitis / Q000150:complications / Q000523:psychology / Q000628:therapy*; D008279:Magnetic Resonance Imaging; D008297:Male; D001523:Mental Disorders / Q000209:etiology; D008775:Methylprednisolone / Q000627:therapeutic use; D009483:Neuropsychological Tests; D011239:Prednisolone / Q000627:therapeutic use; D011506:Proteins / Q000276:immunology*; D011597:Psychomotor Performance / Q000502:physiology; D012640:Seizures / Q000209:etiology; D014057:Tomography, X-Ray Computed
chemical_list: D000893:Anti-Inflammatory Agents; D000906:Antibodies; D016756:Immunoglobulins, Intravenous; D047908:Intracellular Signaling Peptides and Proteins; C116499:LGI1 protein, human; D011506:Proteins; D011239:Prednisolone; D008775:Methylprednisolone