title: Proliferative and nonproliferative lesions of the rat and mouse mammary, Zymbal's, preputial, and clitoral glands.
abstract: The mammary gland of laboratory rodents is an important organ for the evaluation of effects of xenobiotics, especially those that perturb hormonal homeostasis or are potentially carcinogenic. Mammary gland cancer is a leading cause of human mortality and morbidity worldwide and is a subject of major research efforts utilizing rodent models. Zymbal's, preputial, and clitoral glands are standard tissues that are evaluated in animal models that enable human risk assessment of xenobiotics. A widely accepted and utilized international harmonization of nomenclature for mammary, Zymbal's, preputial, and clitoral gland lesions in laboratory animals will improve diagnostic alignment among regulatory and scientific research organizations and enrich international exchanges of information among toxicologists and pathologists.
authors.affiliation: Eli Lilly and Co., Lilly Research Laboratories, Indianapolis, Indiana 46225, USA. rudmanndg@lilly.com
authors.forename: Daniel
authors.initials: D
authors.lastname: Rudmann
authors.forename: Robert
authors.initials: R
authors.lastname: Cardiff
authors.forename: Luc
authors.initials: L
authors.lastname: Chouinard
authors.forename: Dawn
authors.initials: D
authors.lastname: Goodman
authors.forename: Karin
authors.initials: K
authors.lastname: Küttler
authors.forename: Heike
authors.initials: H
authors.lastname: Marxfeld
authors.forename: Alfredo
authors.initials: A
authors.lastname: Molinolo
authors.forename: Silke
authors.initials: S
authors.lastname: Treumann
authors.forename: Katsuhiko
authors.initials: K
authors.lastname: Yoshizawa
mesh_terms: D000818:Animals; D000830:Animals, Laboratory; D035843:Biomedical Research / Q000592:standards*; D002987:Clitoris / Q000737:chemistry / Q000166:cytology / Q000473:pathology*; D005260:Female; D005831:Genital Diseases, Female / Q000145:classification / Q000473:pathology; D006651:Histocytochemistry; D008321:Mammary Glands, Animal / Q000737:chemistry / Q000166:cytology / Q000473:pathology*; D008325:Mammary Neoplasms, Experimental / Q000737:chemistry / Q000473:pathology; D051379:Mice; D009374:Neoplasms, Experimental / Q000737:chemistry / Q000145:classification / Q000473:pathology*; D051381:Rats; D012627:Sebaceous Glands / Q000737:chemistry / Q000166:cytology / Q000473:pathology*; D009626:Terminology as Topic; D018675:Toxicity Tests / Q000592:standards; D015262:Xenobiotics
chemical_list: D015262:Xenobiotics