title: Efficacy and safety of subcutaneous allergen-specific immunotherapy with depigmented polymerized mite extract in atopic dermatitis.
abstract: BACKGROUND
  Exposure to house dust mites (HDMs) aggravates the course of atopic dermatitis (AD) in patients sensitized to HDMs.
  
  
  OBJECTIVE
  This study investigated the efficacy and safety of subcutaneous allergen-specific immunotherapy with the use of depigmented polymerized mite extract as an add-on therapy to basic (ie, topical and, as necessary, systemic) medication.
  
  
  METHODS
  Patients (n = 168) were recruited in a randomized, double-blind, placebo-controlled parallel group phase III study conducted in Germany (21 sites), in adult patients with AD aggravated by HDMs. The primary end points of the study were the assessments of the area under the curves of the total Severity Scoring Atopic Dermatitis (SCORAD) score and of the use of basic medication during the 18-month treatment period. Post hoc subgroup analyses were also performed.
  
  
  RESULTS
  Overall efficacy analysis of the intention-to-treat and per-protocol study populations showed no statistically significant differences between the active treatment and placebo groups. However, the subgroup of patients with severe AD (SCORAD > 50) showed a statistically significant reduction of the median total SCORAD by 18% (P = .02) compared with placebo. The frequency of adverse reactions was similar in both groups, suggesting the safety of the active treatment.
  
  
  CONCLUSIONS
  Although subcutaneous allergen-specific immunotherapy showed no statistically significant difference in the overall population of patients with AD, statistically significant reduction of the total SCORAD could be achieved in a subgroup of patients with severe AD.
authors.affiliation: Department of Dermatology and Allergy, University of Bonn, Bonn, Germany. natalija.novak@ukb.uni-bonn.de
authors.forename: Natalija
authors.initials: N
authors.lastname: Novak
authors.forename: Thomas
authors.initials: T
authors.lastname: Bieber
authors.forename: Matthias
authors.initials: M
authors.lastname: Hoffmann
authors.forename: Regina
authors.initials: R
authors.lastname: Fölster-Holst
authors.forename: Bernhard
authors.initials: B
authors.lastname: Homey
authors.forename: Thomas
authors.initials: T
authors.lastname: Werfel
authors.forename: Angelika
authors.initials: A
authors.lastname: Sager
authors.forename: Torsten
authors.initials: T
authors.lastname: Zuberbier
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000818:Animals; D019540:Area Under Curve; D003876:Dermatitis, Atopic / Q000628:therapy*; D003888:Desensitization, Immunologic / Q000009:adverse effects; D004311:Double-Blind Method; D006801:Humans; D007279:Injections, Subcutaneous; D008875:Middle Aged; D008925:Mites / Q000276:immunology*; D011788:Quality of Life