title: Familial breast cancer registry program in patients referred to the cancer institute of Iran.
abstract: BACKGROUND
  Annually a considerable number of people die because of breast cancer, a common disease among women also in Iran. Identifying risk factors and susceptible people can lead to prevention or at least early diagnosis. Among susceptibility risks, 5-10% of patients have a family history predisposing factor which can influence the risk of incidence among the family. Having a registry program can be a more practical way to screen high risk families for preventive planning.
  
  
  METHODS
  Based on inclusion criteria, a questionnaire was prepared and after a pilot study on a small number of patients, actual data were collected on 400 patients and processed in SPSS 16.0.
  
  
  RESULTS
  Totally, 28.2%of the patients were younger than 40 years old and 36.8% had the included criteria for familial breast cancer (FBC). 102 patient's samples could be compared for receptor presentation. Similar to other studies, the number of triple negative breast cancers increased as the age decreased.
  
  
  CONCLUSIONS
  The high percentage of patients with FBC among 400 cases in this study demonstrates that in order to design an infrastructural diagnostic protocol and screening of patients with FBC, a precise survey related to frequency and founder mutations of FBC is needed nationwide.
authors.affiliation: Department of Genetics, Cancer Research Center, Cancer Institute of Iran, Tehran, Iran.
authors.forename: Tayebeh
authors.initials: T
authors.lastname: Sabokbar
authors.forename: Elias
authors.initials: E
authors.lastname: Khajeh
authors.forename: Foad
authors.initials: F
authors.lastname: Taghdiri
authors.forename: Vahideh
authors.initials: V
authors.lastname: Peyghambari
authors.forename: Reza
authors.initials: R
authors.lastname: Shirkoohi
mesh_terms: D000328:Adult; D001943:Breast Neoplasms / Q000453:epidemiology*; D005190:Family; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D007492:Iran / Q000453:epidemiology; D008297:Male; D008403:Mass Screening; D012042:Registries; D012307:Risk Factors; D011795:Surveys and Questionnaires