title: Obstructive sleep apnoea in relation to rheumatic disease.
abstract: Sleep problems are common concerns in rheumatology patients and have been independently linked to increased pain perception and fatigue severity. Evidence supports an increased prevalence of primary sleep disorders, including sleep apnoea, in some rheumatic disease populations, particularly RA. Obstructive sleep apnoea is a significant public health concern and contributes to increased cardiovascular morbidity and mortality. Patients with obstructive sleep apnoea have also been found to have elevations in circulating acute-phase markers and pro-inflammatory cytokines. Co-existence of sleep apnoea in rheumatic disease patients may influence the severity of reported symptoms of pain and fatigue, accelerate the risk of cardiovascular events and possibly influence levels of circulating inflammatory markers and mediators. In this article we review the risk factors, prevalence and impact of sleep apnoea from a rheumatological perspective. Additionally, we recommend considering sleep apnoea screening in patients with rheumatic disease and, when appropriate, referral to a specialized sleep disorders clinic.
authors.affiliation: Division of Rheumatology, Department of Medicine, Royal University Hospital, University of Saskatchewan, Saskatoon, SK S7N 0W8, Canada.
authors.forename: Regina M
authors.initials: RM
authors.lastname: Taylor-Gjevre
authors.forename: Bindu V
authors.initials: BV
authors.lastname: Nair
authors.forename: John A
authors.initials: JA
authors.lastname: Gjevre
mesh_terms: D045422:Continuous Positive Airway Pressure; D006801:Humans; D007249:Inflammation / Q000150:complications; D009765:Obesity / Q000150:complications; D012216:Rheumatic Diseases / Q000150:complications*; D012307:Risk Factors; D012720:Severity of Illness Index; D020181:Sleep Apnea, Obstructive / Q000150:complications* / Q000628:therapy