title: Cytomegalovirus seropositivity is associated with glucose regulation in the oldest old. Results from the Leiden 85-plus Study.
abstract: BACKGROUND
  Cytomegalovirus (CMV) infection has been reported to contribute to the pathogenesis of type 1 diabetes and post-transplantation diabetes. However, CMV infection has not been evaluated as a possible risk factor for type 2 diabetes. Our aim was to investigate potential associations between CMV seropositivity, CMV IgG antibody level and glucose regulation in the oldest old.
  
  
  RESULTS
  CMV seropositive subjects were more likely to have type 2 diabetes (17.2% vs 7.9%, p = 0.016), had a higher level of HbA1c (p = 0.014) and higher non-fasting glucose (p = 0.024) in the oldest olds. These associations remained significant after adjustment for possible confounders. CMV IgG antibody level was not significantly associated with glucose regulation (all p > 0.05).
  
  
  CONCLUSIONS
  In the oldest old, CMV seropositivity is significantly associated with various indicators of glucose regulation. This finding suggests that CMV infection might be a risk factor for the development of type 2 diabetes in the elderly.
authors.affiliation: Department of Gerontology and Geriatrics, Leiden University Medical Center, Albinusdreef 2, Leiden, 2333 ZA, The Netherlands. A.B.Maier@lumc.nl.
authors.forename: Sijia
authors.initials: S
authors.lastname: Chen
authors.forename: Anton J M
authors.initials: AJ
authors.lastname: de Craen
authors.forename: Yotam
authors.initials: Y
authors.lastname: Raz
authors.forename: Evelyna
authors.initials: E
authors.lastname: Derhovanessian
authors.forename: Ann C T M
authors.initials: AC
authors.lastname: Vossen
authors.forename: Rudi G J
authors.initials: RG
authors.lastname: Westendorp
authors.forename: Graham
authors.initials: G
authors.lastname: Pawelec
authors.forename: Andrea B
authors.initials: AB
authors.lastname: Maier