title: Quantitative assessment of cerebral hemodynamics using single photon emission computed tomography with venous blood sampling.
abstract: OBJECTIVE
  Quantitative cerebral blood flow (CBF) measured by single photon emission computed tomography (SPECT) with arterial blood sampling is one of the most reliable methods to assess the hemodynamics in individual patients. SPECT with venous blood sampling is less invasive. The present study compared the measurement of CBF using N-isopropyl-p-(iodine-123)-iodoamphetamine SPECT with venous blood sampling and with arterial blood sampling in patients with major cerebral artery occlusive disease.
  
  
  METHODS
  Two normal subjects and 14 patients with major cerebral artery occlusive disease underwent SPECT with arterial and venous blood sampling. The microsphere method was used for quantitative SPECT imaging. Whole brain radioactivity was corrected when the detectors rotated in the forward direction (F1-F7). Venous sampling was performed 30min after radiotracer injection. Arterial blood radioactivity was estimated by multiple regression analysis from these parameters. The cerebrovascular reactivity to acetazolamide was also measured.
  
  
  RESULTS
  Multiple regression analysis established the following formula:(where Ca10 is the arterial blood radioactivity at 10min, F1-F7 are the whole brain radioactivity in the forward direction, Cv30 is the venous blood radioactivity at 30min). Mean CBF values were 32.2±6.6ml/100g/min for measured arterial radioactivity and 42.2±7.8ml/100g/min for calculated arterial radioactivity based on venous radioactivity.
  
  
  CONCLUSIONS
  The present modified method of calculating quantitative CBF from whole brain and venous blood radioactivities correlated well with values determined with arterial blood radioactivity.
authors.affiliation: Department of Neurosurgery, Kohnan Hospital, Sendai, Japan. tainoue@kohnan-sendai.or.jp
authors.forename: Takashi
authors.initials: T
authors.lastname: Inoue
authors.forename: Miki
authors.initials: M
authors.lastname: Fujimura
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Shimizu
authors.forename: Yoshitake
authors.initials: Y
authors.lastname: Takahashi
authors.forename: Teiji
authors.initials: T
authors.lastname: Tominaga
mesh_terms: D000086:Acetazolamide; D000328:Adult; D000368:Aged; D001157:Arterial Occlusive Diseases / Q000097:blood / Q000503:physiopathology; D001921:Brain / Q000000981:diagnostic imaging*; D002560:Cerebrovascular Circulation / Q000502:physiology*; D002561:Cerebrovascular Disorders / Q000097:blood / Q000503:physiopathology; D004232:Diuretics; D005260:Female; D006439:Hemodynamics / Q000502:physiology*; D006801:Humans; D007091:Image Processing, Computer-Assisted; D020367:Iofetamine; D008297:Male; D008875:Middle Aged; D019275:Radiopharmaceuticals; D012044:Regression Analysis; D015899:Tomography, Emission-Computed, Single-Photon
chemical_list: D004232:Diuretics; D019275:Radiopharmaceuticals; D020367:Iofetamine; D000086:Acetazolamide