title: A new jasmonic acid stereoisomeric derivative induces apoptosis via reactive oxygen species in human prostate cancer cells.
abstract: With the aim of identifying novel agents with antigrowth and pro-apoptotic activity on prostate cancer cells, in the present study, we evaluated the effect of a (-)-jasmonic acid derivative, the 3-hydroxy-2(S)-(2Z-butenyl)-cyclopentane-1(S)-acetic acid, obtained by biotransformation, on cell growth in androgen-sensitive (LNCaP) and androgen-insensitive (DU-145) human prostate cancer cells. The results obtained show that the new compound was able to inhibit the growth of both prostate cancer cells. In addition, our data seem to indicate that the apoptosis evocated by this new molecule, at least in part, appears to be associated with an increase of reactive oxygen species (ROS) production.
authors.affiliation: Department of Drug Sciences, Biochemistry Section, University of Catania, Catania, Italy. alrusso@unict.it
authors.forename: Alessandra
authors.initials: A
authors.lastname: Russo
authors.forename: C Luis
authors.initials: CL
authors.lastname: Espinoza
authors.forename: Silvia
authors.initials: S
authors.lastname: Caggia
authors.forename: Juan A
authors.initials: JA
authors.lastname: Garbarino
authors.forename: Hugo
authors.initials: H
authors.lastname: Peña-Cortés
authors.forename: T Marcela
authors.initials: TM
authors.lastname: Carvajal
authors.forename: Venera
authors.initials: V
authors.lastname: Cardile
mesh_terms: D017209:Apoptosis / Q000187:drug effects*; D003517:Cyclopentanes / Q000494:pharmacology*; D006801:Humans; D008297:Male; D054883:Oxylipins / Q000494:pharmacology*; D011471:Prostatic Neoplasms / Q000378:metabolism / Q000473:pathology*; D017382:Reactive Oxygen Species / Q000378:metabolism*; D013237:Stereoisomerism
chemical_list: D003517:Cyclopentanes; D054883:Oxylipins; D017382:Reactive Oxygen Species; C011006:jasmonic acid