title: Bone-bonding properties of Ti metal subjected to acid and heat treatments.
abstract: The effects of surface treatment on the bone-bonding properties of Ti metal were examined by both mechanical detaching test and histological observation after implantation into rabbit tibiae for various periods ranging from 4 to 26 weeks. The bone-bonding ability of Ti metal, which is extremely low as it is abraded, was hardly increased by simple heat treatment at 600 °C or treatment with H(2)SO(4)/HCl mixed acid alone, but was markedly increased by the heat treatment after the acid treatment. Even Ti metal that had been previously subjected to NaOH treatment showed considerably high bone-bonding ability after acid and heat treatments. Such high bonding abilities were attributed to their high apatite-forming ability in the body environment. Their high apatite-forming abilities were attributed to a high positive surface charge, and not to the type of crystalline phase or specific roughness of their surfaces. The present study has demonstrated that acid and subsequent heat treatments are effective for conferring stable fixation properties on Ti metal implants.
authors.affiliation: Department of Orthopaedic Surgery, Graduate School of Medicine, Kyoto University, 54 Kawahara-cho, Shougoin, Kyoto, Japan. kawait@kuhp.kyoto-u.ac.jp
authors.forename: Toshiyuki
authors.initials: T
authors.lastname: Kawai
authors.forename: Mitsuru
authors.initials: M
authors.lastname: Takemoto
authors.forename: Shunsuke
authors.initials: S
authors.lastname: Fujibayashi
authors.forename: Masashi
authors.initials: M
authors.lastname: Neo
authors.forename: Haruhiko
authors.initials: H
authors.lastname: Akiyama
authors.forename: Seiji
authors.initials: S
authors.lastname: Yamaguchi
authors.forename: Deepak K
authors.initials: DK
authors.lastname: Pattanayak
authors.forename: Tomiharu
authors.initials: T
authors.lastname: Matsushita
authors.forename: Takashi
authors.initials: T
authors.lastname: Nakamura
authors.forename: Tadashi
authors.initials: T
authors.lastname: Kokubo
mesh_terms: D000143:Acids / Q000737:chemistry; D000818:Animals; D001031:Apatites / Q000737:chemistry; D018786:Bone Substitutes / Q000737:chemistry; D001842:Bone and Bones / Q000378:metabolism*; D004867:Equipment Design; D006358:Hot Temperature; D006851:Hydrochloric Acid / Q000737:chemistry; D008422:Materials Testing / Q000379:methods*; D008670:Metals / Q000737:chemistry; D019736:Prostheses and Implants; D011817:Rabbits; D012972:Sodium Hydroxide / Q000737:chemistry; D013314:Stress, Mechanical; D013499:Surface Properties; D013696:Temperature; D013977:Tibia / Q000473:pathology*; D014025:Titanium / Q000737:chemistry*
chemical_list: D000143:Acids; D001031:Apatites; D018786:Bone Substitutes; D008670:Metals; D012972:Sodium Hydroxide; D014025:Titanium; D006851:Hydrochloric Acid