title: β-Secretase (BACE1) inhibitory property of loganin isolated from Corni fructus.
abstract: In the course of searching for anti-dementia agents from natural products, loganin isolated from EtOAc fraction of Corni fructus possessed specific inhibitory activity against β-secretase (BACE1) with 9.2 × 10⁻⁵  M and K(i) value of 5.5 × 10⁻⁵ M. Loganin exhibited less inhibitory activity to α-secretase (TACE) and other serine proteases exhibiting that it was a relatively specific inhibitor of BACE1. These novel findings suggest that loganin may be used to attenuate the progression and/or prevention of Alzheimer's disease.
authors.affiliation: a Department of Food Science and Nutrition , Dong-A University , 840 Hadan-dong , Saha-gu , Busan 604-714 , Korea.
authors.forename: Kumju
authors.initials: K
authors.lastname: Youn
authors.forename: Woo-Sik
authors.initials: WS
authors.lastname: Jeong
authors.forename: Mira
authors.initials: M
authors.lastname: Jun
mesh_terms: D053829:Amyloid Precursor Protein Secretases / Q000378:metabolism*; D016282:Aspartic Acid Endopeptidases / Q000378:metabolism*; D029768:Cornus / Q000737:chemistry*; D004789:Enzyme Activation / Q000187:drug effects; D039823:Iridoids / Q000737:chemistry* / Q000494:pharmacology*
chemical_list: D039823:Iridoids; D053829:Amyloid Precursor Protein Secretases; D016282:Aspartic Acid Endopeptidases; C509280:BACE1 protein, human; C059516:loganin