title: A prospective, multinational pharmacoepidemiological study of clinical conversion to sirolimus immunosuppression after renal transplantation.
abstract: This prospective pharmacoepidemiological study examined treatment and outcomes in patients converted to sirolimus (SRL) after renal transplantation. 484 subjects in 36 centres in 7 countries were followed for up to 5 years. Principal reasons for conversion were declining graft function (146/484, 30%) and side effects of prior therapy (144/484, 30%) and the major treatment combinations after conversion were SRL ± MMF (62%), SRL + TAC (21.5%), SRL + CSA (16.5%). The cumulative probability of biopsy-confirmed acute rejection (BCAR) was 5% (n = 22), death-censored graft loss 12% (n = 56) and death 6% (n = 22), and there was no significant relationship to the treatment combination employed. Median calculated creatinine clearance was 48.4 (29.3, 64.5) mL/min at conversion, rising to 54.1 (41.2, 69.0) mL/min at month 1, 55.7 (39.0, 73.0) mL/min at month 12, 58.6 (39.7, 75.2) mL/min at two years and 60.9 (36.0, 77.0) mL/min at three years post-conversion. The most common adverse events were hypertension (47%), hyperlipidemia (26%), urinary tract infections (25%), anaemia (24%) and diarrhea (14%), and cardiac events, hyperlipemia and CMV infection were more common in patients converted during the first year. SRL was most frequently combined with MMF after conversion, but principal clinical outcomes were not significantly influenced by the treatment combination employed in normal practice.
authors.affiliation: Division of Nephrology, Hennepin County Medical Center, Minneapolis, MN 55415, USA.
authors.forename: Bertram L
authors.initials: BL
authors.lastname: Kasiske
authors.forename: Bjorn
authors.initials: B
authors.lastname: Nashan
authors.forename: Maria
authors.initials: M
authors.lastname: Del Carmen Rial
authors.forename: Pablo
authors.initials: P
authors.lastname: Raffaele
authors.forename: Graeme
authors.initials: G
authors.lastname: Russ
authors.forename: Josep
authors.initials: J
authors.lastname: Campistol
authors.forename: Mark D
authors.initials: MD
authors.lastname: Pescovitz
authors.forename: Paul A
authors.initials: PA
authors.lastname: Keown