title: Implementing a clinical pharmacy survey of adverse drug events in a French emergency department.
abstract: BACKGROUND
  The prevalence of adverse drug events (ADEs) occurring in the ambulatory setting is high, requiring the development of a coherent and comprehensive patient-safety policy framework. Former experiences demonstrated that emergency department (ED) surveillance can help characterise the burden of outpatient ADEs. We developed a clinical pharmacy programme called the clinical pharmacy survey of adverse drug events (CPSA) to support interventions and research projects in the area of ADE prevention and management.
  
  
  OBJECTIVE
  To design a survey to identify and describe ADEs in patients visiting the medical ED of our tertiary care hospital. We report the results of the first 2 years of CPSA implementation and an assessment of its performance.
  
  
  METHODS
  The medical ED of a French 3,000-bed tertiary care hospital.
  
  
  METHODS
  Between January 2008 and December 2009, adult patients visiting our medical ED were included during randomised time slots. Data were collected by pharmacy students. ADEs were documented by a trained physician pharmacist team using the chart review method.
  
  
  METHODS
  The primary outcome was the number of patients visiting our ED with an ADE. The CPSA attributes were assessed on the basis of the Centers for Disease Control and Prevention's 2001 updated guidelines for evaluating public health surveillance systems.
  
  
  RESULTS
  Of the 1,035 included patients, 201 experienced an ADE at the ED visit (19.4 %; 95 % confidence interval 15.8-23.0 %). Forty-seven ADEs (23.4 %) were unrelated to the patient's chief complaint. An ADE was the leading cause of 154 in the 1,035 admissions (14.9 %). The assessment of our method on the basis of the Centers for Disease Control and Prevention guidelines showed good performances in terms of data quality, stability, flexibility, timeliness, and acceptability, but not in terms of simplicity and representativeness. The profile of patients with an ADE at admission and detected ADEs did not significantly differ between years 2008 and 2009.
  
  
  CONCLUSIONS
  Our experience demonstrates that clinical pharmacists can successfully implement a survey process of ADEs in an ED over time. Our method seems basic enough to suit most health care facilities with pharmacy students.
authors.affiliation: Emergency Department, Teaching Hospital, Nantes, France. lucien.roulet@gmail.com
authors.forename: Lucien
authors.initials: L
authors.lastname: Roulet
authors.forename: Nathalie
authors.initials: N
authors.lastname: Asseray
authors.forename: Martin
authors.initials: M
authors.lastname: Dary
authors.forename: Anne
authors.initials: A
authors.lastname: Chiffoleau
authors.forename: Gilles
authors.initials: G
authors.lastname: Potel
authors.forename: Françoise
authors.initials: F
authors.lastname: Ballereau
mesh_terms: D000328:Adult; D016907:Adverse Drug Reaction Reporting Systems / Q000706:statistics & numerical data*; D000368:Aged; D000369:Aged, 80 and over; D016009:Chi-Square Distribution; D064420:Drug-Related Side Effects and Adverse Reactions / Q000175:diagnosis / Q000453:epidemiology*; D004636:Emergency Service, Hospital / Q000706:statistics & numerical data*; D005260:Female; D005602:France / Q000453:epidemiology; D019538:Health Care Surveys; D006742:Hospital Bed Capacity; D006760:Hospitalization / Q000706:statistics & numerical data; D006801:Humans; D008297:Male; D008875:Middle Aged; D017891:Pharmacoepidemiology; D010607:Pharmacy Service, Hospital / Q000706:statistics & numerical data*; D015397:Program Evaluation; D062606:Tertiary Care Centers / Q000706:statistics & numerical data; D013997:Time Factors