title: Amyloidosis of the orbit and adnexae.
abstract: OBJECTIVE
  To present a series of patients with orbital and adnexal amyloidosis and illustrate the diversity of disease and the challenges of managing such cases.
  
  
  METHODS
  Descriptive case series of ten patients with biopsy proven amyloidosis involving the orbit, conjunctiva and eyelids. The presentation, clinical findings and management are discussed for each case.
  
  
  RESULTS
  All patients had some form of eyelid abnormality or malposition. Presenting complaints included ptosis, epiphora and ocular discomfort. Other clinical findings included conjunctival lesions and proptosis. The majority of patients had localised amyloidosis and one patient had systemic disease. Conservative management included lubrication and the use of bandage contact lenses. Surgical management included debulking, ptosis or other lid surgery.
  
  
  CONCLUSIONS
  Amyloidosis can present to an Occuloplastic clinic in a wide variety of ways. Definitive diagnosis is based on the histopathological findings. Management is often challenging. Multi-disciplinary team involvement is critical in view of its systemic associations.
authors.affiliation: Manchester Royal Eye Hospital, Central Manchester University Hospitals NHS Foundation Trust , Manchester, UK. dania1979@doctors.org.uk
authors.forename: Dania
authors.initials: D
authors.lastname: Al-Nuaimi
authors.forename: Priya R
authors.initials: PR
authors.lastname: Bhatt
authors.forename: Laura
authors.initials: L
authors.lastname: Steeples
authors.forename: Luciane
authors.initials: L
authors.lastname: Irion
authors.forename: Richard
authors.initials: R
authors.lastname: Bonshek
authors.forename: Brian
authors.initials: B
authors.lastname: Leatherbarrow
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000686:Amyloidosis / Q000473:pathology* / Q000628:therapy; D001706:Biopsy; D003229:Conjunctival Diseases / Q000473:pathology* / Q000628:therapy; D005094:Exophthalmos / Q000473:pathology; D005141:Eyelid Diseases / Q000473:pathology* / Q000628:therapy; D005260:Female; D006801:Humans; D007766:Lacrimal Apparatus Diseases / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009916:Orbital Diseases / Q000473:pathology* / Q000628:therapy; D012008:Recurrence