title: Potent HGF/c-Met axis inhibitors from Eucalyptus globulus: the coupling of phloroglucinol and sesquiterpenoid is essential for the activity.
abstract: Eucalyptin A (1), together with two known compounds 2 and 3 exhibiting potent inhibition on HGF/c-Met axis, was discovered from the fruits of Eucalyptus globulus. 1 possessed an unprecedented carbon framework of phloroglucinol-coupled sesquiterpenoid, and its structure was elucidated by spectroscopic method and ECD calculation. A brief structure-activity relationship discussion indicated that the coupling of a phloroglucinol and a sesquiterpenoid is essential for the activity.
authors.affiliation: State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zu Chong Zhi Road, Zhangjiang Hi-Tech Park, Shanghai, 201203, People's Republic of China.
authors.forename: Sheng-Ping
authors.initials: SP
authors.lastname: Yang
authors.forename: Xiao-Wei
authors.initials: XW
authors.lastname: Zhang
authors.forename: Jing
authors.initials: J
authors.lastname: Ai
authors.forename: Li-She
authors.initials: LS
authors.lastname: Gan
authors.forename: Jin-Biao
authors.initials: JB
authors.lastname: Xu
authors.forename: Ying
authors.initials: Y
authors.lastname: Wang
authors.forename: Zu-Shang
authors.initials: ZS
authors.lastname: Su
authors.forename: Lu
authors.initials: L
authors.lastname: Wang
authors.forename: Jian
authors.initials: J
authors.lastname: Ding
authors.forename: Mei-Yu
authors.initials: MY
authors.lastname: Geng
authors.forename: Jian-Min
authors.initials: JM
authors.lastname: Yue
mesh_terms: D000818:Animals; D002465:Cell Movement / Q000187:drug effects; D049109:Cell Proliferation / Q000187:drug effects; D004285:Dogs; D005052:Eucalyptus / Q000737:chemistry*; D017228:Hepatocyte Growth Factor / Q000037:antagonists & inhibitors* / Q000494:pharmacology; D006801:Humans; D061985:Madin Darby Canine Kidney Cells; D010696:Phloroglucinol / Q000737:chemistry*; D010936:Plant Extracts / Q000737:chemistry* / Q000494:pharmacology*; D047428:Protein Kinase Inhibitors / Q000737:chemistry / Q000494:pharmacology; D019859:Proto-Oncogene Proteins c-met / Q000037:antagonists & inhibitors*; D012717:Sesquiterpenes / Q000737:chemistry*; D013329:Structure-Activity Relationship; D014568:Urokinase-Type Plasminogen Activator / Q000037:antagonists & inhibitors
chemical_list: D010936:Plant Extracts; D047428:Protein Kinase Inhibitors; D012717:Sesquiterpenes; D017228:Hepatocyte Growth Factor; D010696:Phloroglucinol; D019859:Proto-Oncogene Proteins c-met; D014568:Urokinase-Type Plasminogen Activator