title: PET/MR for therapy response evaluation in malignant lymphoma: initial experience.
abstract: OBJECTIVE
  To evaluate the feasibility of positron emission tomography/magnetic resonance imaging (PET/MR) with (18)fluoro-2-deoxyglucose (FDG) for therapy response evaluation of malignant lymphoma.
  
  
  METHODS
  Nine patients with malignant lymphoma who underwent FDG-PET/MR before and after chemotherapy were included in this retrospective study. Average time between the two scans was 70 days. The scans were evaluated independently by two nuclear medicine physicians. The Ann Arbor classification was used to describe lymphoma stage. Furthermore, the readers also rated PET image quality using a five point scale. Weighted kappa (κ) was used to calculate interrater agreement.
  
  
  RESULTS
  The initial scan showed foci of increased FDG uptake in all patients, with Ann Arbor stage varying between I and IV. In the follow-up examination, all but one patient showed complete response to chemotherapy. PET image quality was rated as very good or excellent for all scans. Interrater agreement was excellent regarding Ann Arbor stage (κ = 0.97) and good regarding image quality (κ = 0.41).
  
  
  CONCLUSIONS
  PET/MR shows promising initial results for therapy response evaluation in lymphoma patients.
authors.affiliation: Department of Radiology, Dresden University Hospital, Fetscherstr. 74, 01307 Dresden, Germany. ivan.platzek@uniklinikum-dresden.de
authors.forename: Ivan
authors.initials: I
authors.lastname: Platzek
authors.forename: Bettina
authors.initials: B
authors.lastname: Beuthien-Baumann
authors.forename: Jens
authors.initials: J
authors.lastname: Langner
authors.forename: Manuel
authors.initials: M
authors.lastname: Popp
authors.forename: Georg
authors.initials: G
authors.lastname: Schramm
authors.forename: Rainer
authors.initials: R
authors.lastname: Ordemann
authors.forename: Michael
authors.initials: M
authors.lastname: Laniado
authors.forename: Jörg
authors.initials: J
authors.lastname: Kotzerke
authors.forename: Jörg
authors.initials: J
authors.lastname: van den Hoff
mesh_terms: D000293:Adolescent; D000328:Adult; D005240:Feasibility Studies; D005260:Female; D019788:Fluorodeoxyglucose F18; D006801:Humans; D008223:Lymphoma / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000473:pathology*; D008279:Magnetic Resonance Imaging / Q000295:instrumentation / Q000379:methods*; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D049268:Positron-Emission Tomography / Q000295:instrumentation / Q000379:methods*; D019275:Radiopharmaceuticals; D012189:Retrospective Studies; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome
chemical_list: D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18