title: Fibrinogen interaction with the red blood cell membrane.
abstract: A brief review of the fibrinogen molecule composition and structure is presented like as an introduction to the effects of this plasma protein on the red blood cell hemorheoplogical properties namely erythrocyte aggregation tendency and deformability ability. The protein membrane RBC target for fibrinogen is also highlight as well as the erythrocyte signal transduction pathway associated with nitric oxide mobilization resulting from its binding.
authors.affiliation: Institute of Biochemistry, Institute of Molecular Medicine, Faculty of Medicine University of Lisbon, Lisbon, Portugal. carlotasaldanha@fm.ul.pt
authors.forename: Carlota
authors.initials: C
authors.lastname: Saldanha
mesh_terms: D000818:Animals; D051928:CD47 Antigen / Q000097:blood; D004903:Erythrocyte Aggregation / Q000502:physiology; D004907:Erythrocyte Deformability / Q000502:physiology; D004910:Erythrocyte Membrane / Q000378:metabolism*; D005340:Fibrinogen / Q000737:chemistry / Q000502:physiology*; D006801:Humans; D008297:Male; D009569:Nitric Oxide / Q000097:blood
chemical_list: D051928:CD47 Antigen; D009569:Nitric Oxide; D005340:Fibrinogen