title: Genetic polymorphisms of antioxidant enzymes in preterm infants.
abstract: BACKGROUND
  Oxidative stress (OS) is significantly involved in the development of several complications associated with preterm birth, such as respiratory distress syndrome (RDS), bronchopulmonary dysplasia (BPD), retinopathy of prematurity (ROP) and intraventricular hemorrhage (IVH). Evidence is growing about the associations between single nucleotide polymorphisms (SNPs) in genes involved in OS or antioxidant response and the occurrence of neonatal morbidities.
  
  
  OBJECTIVE
  To assess whether SNPs in genes of superoxide dismutase (SOD) and catalase (CAT), involved in antioxidant pathways, correlate with the occurrence of RDS, BPD, IVH and ROP in preterm neonates.
  
  
  METHODS
  We performed a retrospective study involving neonates <28 weeks of gestational age.
  
  
  RESULTS
  We demonstrated that rs8192287 SOD3 polymorphism is an independent protective factor for IVH, while rs4880 and rs5746136 SOD2 polymorphisms are associated with lower gestational age and birth weight. Haplotypes reconstruction showed that SOD1 (GG) decreased the risk of RDS, IVH and ROP; SOD2 (GT) increased the risk of BPD and decreased the risk of RDS, IVH, and ROP; SOD3 (TGC) decreased the risk of BPD and IVH; and CAT (CTC) decreased the risk of RDS.
  
  
  CONCLUSIONS
  The study of SNPs or haplotypes reconstruction in genes involved in OS or scavenging activity may be helpful in identifying preterm newborns with a particularly high risk of morbidities, who may benefit from specific prevention strategies.
authors.affiliation: Department of Medical and Surgical Critical Care, Neonatology Section, Careggi University Hospital, Florence, Italy. chiarapoggi@inwind.it
authors.forename: Chiara
authors.initials: C
authors.lastname: Poggi
authors.forename: Betti
authors.initials: B
authors.lastname: Giusti
authors.forename: Anna
authors.initials: A
authors.lastname: Vestri
authors.forename: Elisabetta
authors.initials: E
authors.lastname: Pasquini
authors.forename: Rosanna
authors.initials: R
authors.lastname: Abbate
authors.forename: Carlo
authors.initials: C
authors.lastname: Dani
mesh_terms: D000328:Adult; D000975:Antioxidants / Q000378:metabolism; D002374:Catalase / Q000235:genetics / Q000378:metabolism; D004798:Enzymes / Q000235:genetics* / Q000378:metabolism; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature / Q000378:metabolism; D018384:Oxidative Stress / Q000235:genetics / Q000502:physiology; D011110:Polymorphism, Genetic / Q000502:physiology; D047928:Premature Birth / Q000201:enzymology / Q000235:genetics* / Q000378:metabolism; D012189:Retrospective Studies; D013482:Superoxide Dismutase / Q000235:genetics / Q000378:metabolism; D000072105:Superoxide Dismutase-1; D000099156:Superoxide Dismutase 2
chemical_list: D000975:Antioxidants; D002374:Catalase; D004798:Enzymes; D013482:Superoxide Dismutase; D000072105:Superoxide Dismutase-1; D000099156:Superoxide Dismutase 2; C000606290:SOD1 protein, human; C441642:SOD3 protein, human