title: Chitosan/TPP microparticles obtained by microemulsion method applied in controlled release of heparin.
abstract: This work deals with the preparation of chitosan/tripolyphosphate microparticles (CHT/TPP) using microemulsion system based on water/benzyl alcohol. The morphology of the microparticles was evaluated by scanning electron microscopy (SEM). The microparticles were also characterized through infrared spectroscopy (FTIR) and wide-angle X-ray scattering (WAXS). The morphology and crystallinity of microparticles depended mainly on CHT/TPP ratio. Studies of controlled release of HP were evaluated in distilled water and in simulated gastric fluid. Besides, the profile of HP releasing could be tailored by tuning the CHT/TPP molar ratio. Finally, these prospective results allow the particles to be employed as site-specific HP controlled release system.
authors.affiliation: Grupo de Materiais Poliméricos e Compósitos, GMPC - Departamento de Química, Universidade Estadual de Maringá UEM - Av. Colombo 5790 - CEP 87020-900 Maringá, Paraná, Brazil. afmartins50@yahoo.com.br
authors.forename: Alessandro F
authors.initials: AF
authors.lastname: Martins
authors.forename: Daiane M
authors.initials: DM
authors.lastname: de Oliveira
authors.forename: Antonio G B
authors.initials: AG
authors.lastname: Pereira
authors.forename: Adley F
authors.initials: AF
authors.lastname: Rubira
authors.forename: Edvani C
authors.initials: EC
authors.lastname: Muniz
mesh_terms: D019905:Benzyl Alcohol / Q000737:chemistry; D048271:Chitosan / Q000737:chemistry*; D003692:Delayed-Action Preparations; D004337:Drug Carriers / Q000737:chemistry*; D004655:Emulsions; D006493:Heparin / Q000737:chemistry*; D006863:Hydrogen-Ion Concentration; D008863:Microspheres; D055616:Microtechnology / Q000379:methods*; D011122:Polyphosphates / Q000737:chemistry*; D013696:Temperature; D014867:Water / Q000737:chemistry
chemical_list: D003692:Delayed-Action Preparations; D004337:Drug Carriers; D004655:Emulsions; D011122:Polyphosphates; D014867:Water; D006493:Heparin; D048271:Chitosan; D019905:Benzyl Alcohol; C005692:triphosphoric acid