title: Effect of antioxidant mineral elements supplementation in the treatment of hypertension in albino rats.
abstract: Oxidative stress has been implicated in various pathologies, including hypertension, atherosclerosis, diabetes, and chronic renal disease. The current work was designed with the aim of investigating the potentials of antioxidants copper, manganese, and zinc in the treatment of hypertension in Wistar rats. The rats were fed 8% NaCl diet for 5 weeks and treatment with supplements in the presence of the challenging agent for additional 4 weeks. The supplementation significantly decreased the blood pressure as compared with hypertensive control. The result also indicated significant decreased in the levels of total cholesterol, triglyceride, low-density lipoprotein cholesterol and very low-density lipoprotein cholesterol, malondialdehyde, insulin and increase in the high-density lipoprotein cholesterol, total antioxidant activities, and nitric oxide of the supplemented groups relative to the hypertensive control. The average percentage protection against atherogenesis indicated 47.13 ± 9.60% for all the supplemented groups. The mean arterial blood pressure showed significant positive correlation with glucose, total cholesterol, triglyceride, low-density lipoprotein cholesterol, very low-density lipoprotein cholesterol, atherogenic index, insulin resistance and malondialdehyde while high density lipoprotein-cholesterol and total antioxidant activities showed negative correlation. The result therefore indicated strong relationship between oxidative stress and hypertension and underscores the role of antioxidant minerals in reducing oxidative stress, dyslipidemia, and insulin resistance associated with hypertension.
authors.affiliation: Biochemistry Department, Usmanu Danfodiyo University, PMB, Sokoto 2346, Nigeria. salhajimuhammad@yahoo.com
authors.forename: S A
authors.initials: SA
authors.lastname: Muhammad
authors.forename: L S
authors.initials: LS
authors.lastname: Bilbis
authors.forename: Y
authors.initials: Y
authors.lastname: Saidu
authors.forename: Y
authors.initials: Y
authors.lastname: Adamu
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000494:pharmacology* / Q000627:therapeutic use; D001794:Blood Pressure / Q000187:drug effects*; D003300:Copper / Q000494:pharmacology* / Q000627:therapeutic use; D019587:Dietary Supplements; D006973:Hypertension / Q000188:drug therapy / Q000378:metabolism / Q000473:pathology; D008297:Male; D008345:Manganese / Q000494:pharmacology* / Q000627:therapeutic use; D018384:Oxidative Stress / Q000187:drug effects; D051381:Rats; D017208:Rats, Wistar; D015430:Weight Gain / Q000187:drug effects; D015032:Zinc / Q000494:pharmacology* / Q000627:therapeutic use
chemical_list: D000975:Antioxidants; D008345:Manganese; D003300:Copper; D015032:Zinc