title: Hypolipidemic and antioxidative effects of noni (Morinda citrifolia L.) juice on high- fat/cholesterol-dietary hamsters.
abstract: Noni juice (NJ) is rich in phytochemicals and polysaccharides. Lipid-lowering and antioxidative effects of NJ were investigated in this study. Fifty male hamsters were assigned randomly to one of the following groups: (1) normal diet and distilled water (LFCD); (2) high-fat/cholesterol diet and distilled water (HFCD); (3) HFCD and 3 ml NJ (including 0.20 g solids)/kg BW (NJ_L); (4) HFCD and 6 mL NJ (including 0.40 g solids)/kg BW (NJ_M); (5) HFCD and 9 ml NJ (including 0.60 g solids)/kg BW (NJ_H) for six weeks. NJ supplementation decreased (p < 0.05) serum triacylglycerol, cholesterol, atherogenic index, malondialdehyde levels, and hepatic lipids in HFCD hamsters, whereas serum trolox equivalent antioxidant capacity, glutathione, and fecal lipids in HFCD hamsters were increased (p < 0.05) by NJ supplementation. Although NJ supplementation downregulated (p < 0.05) sterol regulator element binding protein-1c in HFCD hamsters, it upregulated (p < 0.05) hepatic peroxisome proliferator-activated receptor-alpha and uncoupling protein 2 gene expressions in HFCD hamsters. Results demonstrate that NJ promotes cardioprotection in a high-fat/cholesterol diet.
authors.affiliation: Institute of Biochemistry and Biotechnology, Chung Shan Medical University, Taichung 402, Taiwan.
authors.forename: Yi-Ling
authors.initials: YL
authors.lastname: Lin
authors.forename: Chung-Hsi
authors.initials: CH
authors.lastname: Chou
authors.forename: Deng-Jye
authors.initials: DJ
authors.lastname: Yang
authors.forename: Jr-Wei
authors.initials: JW
authors.lastname: Chen
authors.forename: Bor-Show
authors.initials: BS
authors.lastname: Tzang
authors.forename: Yi-Chen
authors.initials: YC
authors.lastname: Chen
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000378:metabolism / Q000494:pharmacology / Q000627:therapeutic use*; D050197:Atherosclerosis / Q000517:prevention & control; D001628:Beverages; D002791:Cholesterol, Dietary / Q000097:blood; D006224:Cricetinae; D059305:Diet, High-Fat; D004041:Dietary Fats / Q000097:blood; D019587:Dietary Supplements; D005243:Feces / Q000737:chemistry; D005638:Fruit; D015870:Gene Expression / Q000187:drug effects; D005978:Glutathione / Q000097:blood; D000960:Hypolipidemic Agents / Q000494:pharmacology / Q000627:therapeutic use*; D007473:Ion Channels / Q000235:genetics / Q000378:metabolism; D050356:Lipid Metabolism / Q000187:drug effects*; D008099:Liver / Q000378:metabolism; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D024101:Mitochondrial Proteins / Q000235:genetics / Q000378:metabolism; D032066:Morinda / Q000737:chemistry*; D047493:PPAR alpha / Q000235:genetics / Q000378:metabolism; D008517:Phytotherapy; D028321:Plant Preparations / Q000494:pharmacology / Q000627:therapeutic use*; D011134:Polysaccharides / Q000494:pharmacology / Q000627:therapeutic use; D011897:Random Allocation; D051780:Sterol Regulatory Element Binding Protein 1 / Q000378:metabolism; D014280:Triglycerides / Q000097:blood; D000071246:Uncoupling Protein 2
chemical_list: D000975:Antioxidants; D002791:Cholesterol, Dietary; D004041:Dietary Fats; D000960:Hypolipidemic Agents; D007473:Ion Channels; D024101:Mitochondrial Proteins; D047493:PPAR alpha; D028321:Plant Preparations; D011134:Polysaccharides; D051780:Sterol Regulatory Element Binding Protein 1; D014280:Triglycerides; D000071246:Uncoupling Protein 2; D008315:Malondialdehyde; D005978:Glutathione