title: Short- and long-term prognostic value of the TIMI risk score after primary percutaneous coronary intervention for ST-segment elevation myocardial infarction.
abstract: OBJECTIVE
  We investigated the short- and long-term predictive value of the TIMI risk score regarding mortality for patients treated with primary percutaneous coronary intervention (PPCI) for ST-elevation myocardial infarction (STEMI).
  
  
  BACKGROUND
  Data on the long-term predictive value of the TIMI risk score is sparse.
  
  
  METHODS
  We used data from 3,609 STEMI patients undergoing PPCI in a high-volume PCI center in The Netherlands. Cumulative event rates according to TIMI score variables were estimated with the Kaplan-Meier method and compared with the log-rank test. The original TIMI risk score was modified based on the availability of the data in the single center registry.
  
  
  RESULTS
  Higher TIMI scores were associated with significantly higher mortality at short- and long-term follow-up (P < 0.001 for both). Age and Killip Class IV at presentation were significant predictors for both short- and long-term mortality. Patients with an anterior MI, heart frequence >100 beats per minute, or systolic blood pressure <100 mmHG had a worse short-term prognosis compared to those who had not. However, long-term mortality was nonsignificantly different. The presence of a history of diabetes/hypertension and weight had only long-term prognostic value. Time to PPCI did not have any prognostic value.
  
  
  CONCLUSIONS
  Our current report shows that the TIMI risk score has both short- and long-term discriminative value. The different variables contained in the TIMI risk score predict short-term prognosis, others predominantly long-term mortality, whereas some are predictive for both.
authors.affiliation: Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.
authors.forename: Peter
authors.initials: P
authors.lastname: Damman
authors.forename: Pier
authors.initials: P
authors.lastname: Woudstra
authors.forename: Wichert J
authors.initials: WJ
authors.lastname: Kuijt
authors.forename: Wouter J
authors.initials: WJ
authors.lastname: Kikkert
authors.forename: Tim P
authors.initials: TP
authors.lastname: van de Hoef
authors.forename: Maik J
authors.initials: MJ
authors.lastname: Grundeken
authors.forename: Ralf E
authors.initials: RE
authors.lastname: Harskamp
authors.forename: Jose P S
authors.initials: JP
authors.lastname: Henriques
authors.forename: Jan J
authors.initials: JJ
authors.lastname: Piek
authors.forename: Jan G P
authors.initials: JG
authors.lastname: Tijssen
authors.forename: Robbert J
authors.initials: RJ
authors.lastname: de Winter
mesh_terms: D000368:Aged; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D009203:Myocardial Infarction / Q000401:mortality* / Q000628:therapy*; D062645:Percutaneous Coronary Intervention; D011379:Prognosis; D018570:Risk Assessment