title: Acute otitis media replacement and recurrence in the Finnish otitis media vaccine trial.
abstract: We reanalyzed the 7-valent pneumococcal conjugate vaccine trial FinOM for prevention of acute otitis media (AOM), with a focus on disease replacement due to other pathogens and AOM recurrence. We found evidence of replacement disease occurring early during the trial follow-up and little vaccine impact on recurrent overall AOM episodes.
authors.affiliation: Department of Vaccination and Immune Protection, National Institute for Health and Welfare, Helsinki, Finland. jukka.jokinen@thl.fi
authors.forename: Jukka
authors.initials: J
authors.lastname: Jokinen
authors.forename: Arto A
authors.initials: AA
authors.lastname: Palmu
authors.forename: Terhi
authors.initials: T
authors.lastname: Kilpi
mesh_terms: D000208:Acute Disease; D002675:Child, Preschool; D005387:Finland / Q000453:epidemiology; D000069443:Heptavalent Pneumococcal Conjugate Vaccine; D006801:Humans; D007223:Infant; D010033:Otitis Media / Q000453:epidemiology / Q000382:microbiology / Q000517:prevention & control*; D022242:Pneumococcal Vaccines / Q000008:administration & dosage*; D012008:Recurrence
chemical_list: D000069443:Heptavalent Pneumococcal Conjugate Vaccine; D022242:Pneumococcal Vaccines