title: Synovial sarcoma individual chemotherapy directed by collagen gel droplet embedded culture drug sensitivity test: A case report.
abstract: The collagen gel droplet embedded culture-drug sensitivity test (CD-DST) is an anticancer drug sensitivity test developed about 10 years ago. This study reports the application of this test in the choice of neoadjuvant chemotherapy for the treatment of one patient with a large synovial sarcoma in the right shank. A 28-year old man presented at our hospital with a large mass in his right shank which had a hard texture and an obscure boundary. The histopathological diagnosis of excisional biopsy specimens was synovial sarcoma with low differentiation. Theprubicin/Cisplatin (THP/CDDP) neoadjuvant chemotherapy was selected based on the results obtained from the CD-DST. After three courses, a computed tomography (CT) scan was performed which indicated that the volume of the tumor had decreased significantly. Additionally, tumor necrosis, as well as the clinical response, showed complete response. The histopathological diagnosis of wide excision specimens indicated a grade III chemotherapy response. The patient was alive and without recurrence after a follow-up of 16 months. Our results indicated that the CD-DST is a useful tool for selecting neoadjuvant chemotherapeutic drugs for patients with synovial sarcoma.
authors.affiliation: Anti-tumor Drug Sensitivity Test Lab, Department of Breast Cancer Pathology and Research Laboratory, Key Laboratory of Breast Cancer Prevention and Therapy of the Ministry of Education, Key Laboratory of Cancer Prevention and Therapy of Tianjin.
authors.forename: Feng
authors.initials: F
authors.lastname: Gu
authors.forename: Yongjie
authors.initials: Y
authors.lastname: Ma
authors.forename: Yu
authors.initials: Y
authors.lastname: Fan
authors.forename: Ronggang
authors.initials: R
authors.lastname: Lang
authors.forename: Ting
authors.initials: T
authors.lastname: Ding
authors.forename: Xishan
authors.initials: X
authors.lastname: Hao
authors.forename: Yun
authors.initials: Y
authors.lastname: Gong
authors.forename: Hisayuki
authors.initials: H
authors.lastname: Kobayahsi
authors.forename: Zhiwei
authors.initials: Z
authors.lastname: Fang
authors.forename: Li
authors.initials: L
authors.lastname: Fu