title: Craving for cannabis in patients with psychotic disorder, their non-affected siblings and healthy controls: psychometric analysis of the obsessive compulsive drug use scale.
abstract: Cannabis use is more common in individuals with non-affective psychotic disorder and their siblings compared to healthy controls. As cannabis use is associated with a greater risk to develop psychotic disorder and an adverse outcome in those who already developed psychosis, it is important to know the role of craving in continued cannabis use and relapse in these vulnerable subjects. Therefore, we examined the validity of the Obsessive Compulsive Drug Use Scale for cannabis (OCDUS-CAN) in patients with non-affective psychotic disorder, their siblings, and healthy controls who all used cannabis in the past year. Simultaneous component analysis (SCA) was used to determine component weights that optimally explained the (co)variance of the OCDUS-CAN variables in these different populations simultaneously. A three-component SCA solution explained 74.2 % of the total variance, and consisted of well-interpretable subscales that could be best described as craving/urge, resistance, and impact. Reliability of the subscales was good. The three subscales significantly discriminated between frequent and infrequent cannabis users. Patients scored higher on the craving/urge and impact scale than siblings and controls, which could be related to primary and secondary symptoms of their disorder. The OCDUS-CAN is well suitable for people with or without vulnerability for psychotic disorder.
authors.affiliation: Department of Psychiatry, Academic Medical Centre, Amsterdam, The Netherlands.
authors.forename: Nienke
authors.initials: N
authors.lastname: Dekker
authors.forename: Maarten
authors.initials: M
authors.lastname: Koeter
authors.forename: Wim
authors.initials: W
authors.lastname: Van Den Brink
mesh_terms: D000293:Adolescent; D000328:Adult; D015331:Cohort Studies; D003192:Compulsive Behavior / Q000175:diagnosis* / Q000209:etiology*; D058999:Drug-Seeking Behavior / Q000502:physiology*; D005260:Female; D006801:Humans; D008297:Male; D002189:Marijuana Abuse / Q000523:psychology*; D008875:Middle Aged; D025341:Principal Component Analysis; D011569:Psychiatric Status Rating Scales; D011594:Psychometrics; D011618:Psychotic Disorders / Q000150:complications* / Q000523:psychology; D015203:Reproducibility of Results; D035781:Siblings / Q000523:psychology; D055815:Young Adult