title: Long-range interactions in nonsense-mediated mRNA decay are mediated by intrinsically disordered protein regions.
abstract: In nonsense-mediated mRNA decay (NMD), large protein complexes cooperate to trigger degradation of mRNA with a premature termination codon. Due to the extreme variation in the size and topology of its mRNA substrate, the structural underpinning of the fidelity of NMD is little understood. Based on bioinformatic predictions, we suggest that fly-casting mechanisms enabled by long disordered regions in NMD complexes are exploited for the underlying effective long-range communication.
authors.affiliation: Institute of Enzymology, Research Centre for Natural Sciences, Hungarian Academy of Sciences, Karolina út 29, H-1113 Budapest, Hungary.
authors.forename: Lajos
authors.initials: L
authors.lastname: Kalmar
authors.forename: Veronika
authors.initials: V
authors.lastname: Acs
authors.forename: Daniel
authors.initials: D
authors.lastname: Silhavy
authors.forename: Peter
authors.initials: P
authors.lastname: Tompa
mesh_terms: D019295:Computational Biology / Q000379:methods; D008954:Models, Biological; D046912:Multiprotein Complexes / Q000737:chemistry* / Q000378:metabolism*; D059365:Nonsense Mediated mRNA Decay; D011485:Protein Binding; D011487:Protein Conformation; D012333:RNA, Messenger / Q000378:metabolism*
chemical_list: D046912:Multiprotein Complexes; D012333:RNA, Messenger