title: Regulatory T-cells in chronic lymphocytic leukemia and autoimmune diseases.
abstract: Regulatory T-cells (Tregs) constitute a small subset of cells that are actively involved in maintaining self-tolerance, in immune homeostasis and in antitumor immunity. They are thought to play a significant role in the progression of cancer and are generally increased in patient with chronic lymphocytic leukemia (CLL). Their number correlates with more aggressive disease status and is predictive of the time to treatment, as well. Moreover, it is now clear that dysregulation in Tregs cell frequency and/or function may result in a plethora of autoimmune diseases, including multiple sclerosis, type 1 diabetes mellitus, myasthenia gravis, systemic lupus erythematosus, autoimmune lymphoproliferative disorders, rheumatoid arthritis, and psoriasis. Efforts are made aiming to develop approaches to deplete Tregs or inhibit their function in cancer and autoimmune disorders, as well.
authors.affiliation: Department of Onco-Hematology, IRCCS "Centro di Riferimento Oncologico della Basilicata", Rionero in Vulture, Italy.
authors.forename: Giovanni
authors.initials: G
authors.lastname: D'Arena
authors.forename: Giovanni
authors.initials: G
authors.lastname: Rossi
authors.forename: Barbara
authors.initials: B
authors.lastname: Vannata
authors.forename: Silvia
authors.initials: S
authors.lastname: Deaglio
authors.forename: Giovanna
authors.initials: G
authors.lastname: Mansueto
authors.forename: Fiorella
authors.initials: F
authors.lastname: D'Auria
authors.forename: Teodora
authors.initials: T
authors.lastname: Statuto
authors.forename: Vittorio
authors.initials: V
authors.lastname: Simeon
authors.forename: Laura
authors.initials: L
authors.lastname: De Martino
authors.forename: Aurelio
authors.initials: A
authors.lastname: Marandino
authors.forename: Giovanni
authors.initials: G
authors.lastname: Del Poeta8
authors.forename: Vincenzo
authors.initials: V
authors.lastname: De Feo
authors.forename: Pellegrino
authors.initials: P
authors.lastname: Musto