title: Multiple sensor array of Mn2+, Fe2+, Co2+, Ni2+, Cu2+, and Zn2+ complexes of a triazole linked imino-phenol based calix[4]arene conjugate for the selective recognition of Asp, Glu, Cys, and His.
abstract: The triazole linked o-imino phenol appended calix[4]arene conjugate (L) has been synthesized and characterized. The structure of L has been established based on single crystal XRD. The binding and recognition behavior of conjugate, L toward the transition metal ions, such as Mn(2+), Fe(2+), Co(2+), Ni(2+), Cu(2+), and Zn(2+), has been demonstrated using fluorescence, absorption and ESI-MS techniques. The in situ prepared complexes of these metal ions, namely, [Mn(2)L], [Fe(2)L], [Co(2)L], [Ni(2)L], [Cu(2)L], and [Zn(2)L] have shown recognition toward Glu, Asp, His and Cys. Hence L provides a multiple sensing molecular tool where the response for the recognition of biologically active amino acids of metalloproteins is elicited by the presence of specific metal ion.
authors.affiliation: Bioinorganic Laboratory, Department of Chemistry, Indian Institute of Technology Bombay, Powai, Mumbai 400 076, India.
authors.forename: Rakesh K
authors.initials: RK
authors.lastname: Pathak
authors.forename: Jayaraman
authors.initials: J
authors.lastname: Dessingou
authors.forename: Chebrolu P
authors.initials: CP
authors.lastname: Rao
mesh_terms: D001224:Aspartic Acid / Q000032:analysis*; D047250:Calixarenes / Q000737:chemistry; D003545:Cysteine / Q000032:analysis*; D018698:Glutamic Acid / Q000032:analysis*; D006639:Histidine / Q000032:analysis*; D007097:Imines / Q000737:chemistry; D008958:Models, Molecular; D015394:Molecular Structure; D009942:Organometallic Compounds / Q000138:chemical synthesis / Q000737:chemistry*; D010636:Phenols / Q000737:chemistry; D013050:Spectrometry, Fluorescence; D021241:Spectrometry, Mass, Electrospray Ionization; D028561:Transition Elements / Q000737:chemistry; D014230:Triazoles / Q000737:chemistry
chemical_list: D007097:Imines; D009942:Organometallic Compounds; D010636:Phenols; D028561:Transition Elements; D014230:Triazoles; C121325:calix(4)arene; D047250:Calixarenes; D001224:Aspartic Acid; D018698:Glutamic Acid; D006639:Histidine; D003545:Cysteine