title: Acute combined central and peripheral demyelination showing anti-aquaporin 4 antibody positivity.
abstract: Neuromyelitis optica spectrum disorder (NMOSD) is characterized by optic neuritis or transverse myelitis with anti-aquaporin 4 (AQP4) antibodies (1). We herein present the case of a patient with NMOSD who also was affected with peripheral neuropathy. A 58-year-old woman developed gait disturbance and sensory impairment in the lower limbs. She exhibited longitudinally extensive transverse myelitis with anti-AQP4 antibodies. Nerve conduction studies showed demyelinating changes. Laboratory findings showed hepatitis-C virus (HCV) infection. Her peripheral neuropathy improved after immunotherapy. There have been no previous reports of NMO or NMOSD associated with neuropathy. The HCV infection or undetermined humoral factors other than the anti-AQP4 antibodies may have caused her peripheral neuropathy.
authors.affiliation: Department of Neurology, Kinki University School of Medicine, Japan.
authors.forename: Mari
authors.initials: M
authors.lastname: Kitada
authors.forename: Hidekazu
authors.initials: H
authors.lastname: Suzuki
authors.forename: Juri
authors.initials: J
authors.lastname: Ichihashi
authors.forename: Rino
authors.initials: R
authors.lastname: Inada
authors.forename: Katsuichi
authors.initials: K
authors.lastname: Miyamoto
authors.forename: Toshiyuki
authors.initials: T
authors.lastname: Takahashi
authors.forename: Yoshiyuki
authors.initials: Y
authors.lastname: Mitsui
authors.forename: Kazuo
authors.initials: K
authors.lastname: Fujihara
authors.forename: Susumu
authors.initials: S
authors.lastname: Kusunoki
mesh_terms: D000208:Acute Disease; D000888:Antibodies, Anti-Idiotypic / Q000097:blood*; D051401:Aquaporin 4 / Q000276:immunology*; D002220:Carbamazepine / Q000627:therapeutic use; D015897:Comorbidity; D005260:Female; D006801:Humans; D008775:Methylprednisolone / Q000627:therapeutic use; D008875:Middle Aged; D009471:Neuromyelitis Optica / Q000188:drug therapy / Q000453:epidemiology* / Q000276:immunology*; D010523:Peripheral Nervous System Diseases / Q000188:drug therapy / Q000453:epidemiology* / Q000276:immunology*; D011239:Prednisolone / Q000627:therapeutic use; D016896:Treatment Outcome
chemical_list: D000888:Antibodies, Anti-Idiotypic; D051401:Aquaporin 4; D002220:Carbamazepine; D011239:Prednisolone; D008775:Methylprednisolone