title: Vascular morphology and tortuosity analysis of breast tumor inside and outside contour by 3-D power Doppler ultrasound.
abstract: This study aimed to evaluate morphologic and tortuous features of vessels inside and outside the tumor region on three-dimensional power Doppler ultrasonography (PDUS) in 113 breast mass lesions, including 60 benign and 53 malignant tumors. Compared with benign lesions, malignant breast lesions had significantly larger values of vascular morphologic and tortuous features and larger tumor sizes. The receiver operating characteristic curve analysis and Student's t-test were used to estimate the performance of a proposed classification system using 13 vascular features and tumor size selected by the neural network. Accuracy, sensitivity, specificity, positive predictive value, negative predictive value and the A(Z) value of the diagnosis performance based on 14 features were 89.38% (101/113), 84.91% (45/53), 93.33% (56/60), 91.84% (45/49), 87.50% (56/64) and 0.9188, respectively. The three-dimensional PDUS morphologic and tortuous characteristics of blood vessels inside and outside breast mass lesions can be effectively used to classify benign and malignant tumors.
authors.affiliation: Department of Medical Imaging, National Taiwan Univesity Hospital and National Taiwan University College of Medicine, Taipei, Taiwan.
authors.forename: Yeun-Chung
authors.initials: YC
authors.lastname: Chang
authors.forename: Yan-Hao
authors.initials: YH
authors.lastname: Huang
authors.forename: Chiun-Sheng
authors.initials: CS
authors.lastname: Huang
authors.forename: Ruey-Feng
authors.initials: RF
authors.lastname: Chang
mesh_terms: D000328:Adult; D000368:Aged; D000465:Algorithms; D001943:Breast Neoplasms / Q000098:blood supply / Q000150:complications / Q000000981:diagnostic imaging*; D005260:Female; D006801:Humans; D007089:Image Enhancement / Q000379:methods; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D021621:Imaging, Three-Dimensional / Q000379:methods*; D008875:Middle Aged; D009389:Neovascularization, Pathologic / Q000150:complications / Q000000981:diagnostic imaging*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D018617:Ultrasonography, Doppler, Pulsed / Q000379:methods*; D016217:Ultrasonography, Mammary / Q000379:methods*