title: [Inhibitor development after changing FVIII/IX products in patients with haemophilia].
abstract: The retrospective observational study surveys the relationship between development of inhibitors in the treatment of haemophilia patients and risk factors such as changing FVIII products. A total of 119 patients were included in this study, 198 changes of FVIII products were evaluated.
  
  
  RESULTS
  During the observation period of 12 months none of the patients developed an inhibitor, which was temporally associated with a change of FVIII products. A frequent change of FVIII products didn't lead to an increase in inhibitor risk. The change between plasmatic and recombinant preparations could not be confirmed as a risk factor. Furthermore, no correlation between treatment regimens, severity, patient age and comorbidities of the patients could be found.
authors.affiliation: Hämophiliezentrum, Medizinische Klinik III, Institut für Transfusionsmedizin, JW-Goethe-Universitätsklinikum, Frankfurt am Main.
authors.forename: S
authors.initials: S
authors.lastname: Kocher
authors.forename: G
authors.initials: G
authors.lastname: Asmelash
authors.forename: V
authors.initials: V
authors.lastname: Makki
authors.forename: S
authors.initials: S
authors.lastname: Müller
authors.forename: S
authors.initials: S
authors.lastname: Krekeler
authors.forename: S
authors.initials: S
authors.lastname: Alesci
authors.forename: W
authors.initials: W
authors.lastname: Miesbach
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D019774:Blood Coagulation Factor Inhibitors / Q000097:blood*; D003029:Coagulants / Q000627:therapeutic use; D057915:Drug Substitution / Q000706:statistics & numerical data; D005164:Factor IX / Q000627:therapeutic use*; D005169:Factor VIII / Q000627:therapeutic use*; D005260:Female; D005858:Germany / Q000453:epidemiology; D006467:Hemophilia A / Q000097:blood* / Q000188:drug therapy* / Q000453:epidemiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D012189:Retrospective Studies; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D019774:Blood Coagulation Factor Inhibitors; D003029:Coagulants; D005169:Factor VIII; D005164:Factor IX