title: miRNA regulates noncoding RNA: a noncanonical function model.
abstract: It has long been assumed that miRNAs can only target protein-coding mRNAs in the cytoplasm. Recent studies, however, reveal miRNAs are also transported from the cytoplasm to the nucleus, where they function in a noncanonical manner to regulate noncoding RNAs. Here, we highlight the working model of these noncanonical miRNAs.
authors.affiliation: Jiangsu Engineering Research Center for microRNA Biology and Biotechnology, State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, 22 Hankou Road, Nanjing 210093, China.
authors.forename: Xi
authors.initials: X
authors.lastname: Chen
authors.forename: Hongwei
authors.initials: H
authors.lastname: Liang
authors.forename: Chen-Yu
authors.initials: CY
authors.lastname: Zhang
authors.forename: Ke
authors.initials: K
authors.lastname: Zen
mesh_terms: D000818:Animals; D001692:Biological Transport; D002467:Cell Nucleus / Q000378:metabolism; D006801:Humans; D035683:MicroRNAs / Q000378:metabolism*; D008954:Models, Biological; D020871:RNA Stability; D062085:RNA, Long Noncoding / Q000819:agonists / Q000037:antagonists & inhibitors / Q000378:metabolism; D015138:RNA, Nuclear / Q000819:agonists / Q000037:antagonists & inhibitors / Q000378:metabolism; D022661:RNA, Untranslated / Q000819:agonists / Q000037:antagonists & inhibitors / Q000378:metabolism*
chemical_list: D035683:MicroRNAs; D062085:RNA, Long Noncoding; D015138:RNA, Nuclear; D022661:RNA, Untranslated