title: Dose-dependent effect in the inhibition of oxidative stress and anticlastogenic potential of ginger in STZ induced diabetic rats.
abstract: Ginger is an important medicinal herb has numerous bioactive components and is used in the management, control and/or treatment of diseases including diabetes mellitus. The present study was undertaken to see the dose-response effect of ginger and evaluate the possible protective effects of dietary ginger on oxidative stress and genotoxicity induced by streptozotocin (STZ) diabetic rats. Inbred male Wistar/NIN rats of 8-9 weeks old were treated with 30 mg/kg of STZ. Rats were divided into different groups of control, diabetic non-treated, and diabetic treated with ginger powder at 0.5%, 1% and 5% respectively. After feeding for a month, blood and tissues were collected to see the effect of ginger on antioxidant status, DNA damage and bone marrow genotoxicity. In this study ginger exerted a protective effect against STZ-induced diabetes by modulating antioxidant enzymes and glutathione and down regulating lipid and protein oxidation and inhibition in genotoxicity in a dose-response manner.
authors.affiliation: Food and Drug Toxicology Research Centre, National Institute of Nutrition (ICMR), PO - Jamai Osmania, Hyderabad 500 007, India. knimy7@yahoo.com
authors.forename: Nirmala
authors.initials: N
authors.lastname: Kota
authors.forename: Virendra Vasant
authors.initials: VV
authors.lastname: Panpatil
authors.forename: Rajakumar
authors.initials: R
authors.lastname: Kaleb
authors.forename: Bhaskar
authors.initials: B
authors.lastname: Varanasi
authors.forename: Kalpagam
authors.initials: K
authors.lastname: Polasa
mesh_terms: D000818:Animals; D001786:Blood Glucose / Q000032:analysis; D004249:DNA Damage / Q000187:drug effects; D003921:Diabetes Mellitus, Experimental / Q000188:drug therapy* / Q000235:genetics / Q000378:metabolism; D004305:Dose-Response Relationship, Drug; D015536:Down-Regulation / Q000187:drug effects; D020939:Zingiber officinale / Q000737:chemistry*; D005978:Glutathione / Q000378:metabolism; D006801:Humans; D007004:Hypoglycemic Agents / Q000008:administration & dosage*; D050356:Lipid Metabolism / Q000187:drug effects*; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D018384:Oxidative Stress / Q000187:drug effects*; D010936:Plant Extracts / Q000008:administration & dosage*; D051381:Rats; D017208:Rats, Wistar
chemical_list: D001786:Blood Glucose; D007004:Hypoglycemic Agents; D010936:Plant Extracts; D008315:Malondialdehyde; D005978:Glutathione