title: α-Glucosidase inhibitory activity of selected Philippine plants.
abstract: BACKGROUND
  Antidesma bunius Spreng. (Phyllantaceae), Averrhoa bilimbi L. (Oxalidaceae), Biophytum sensitivum (L.) DC. (Oxalidaceae), Ceriops tagal (Perr.) C.B. Rob. (Rhizophoraceae), Kyllinga monocephala Rottb. (Cyperaceae), and Rhizophora mucronata Lam. (Rhizophoraceae) are used as remedies to control diabetes. In the present study, these plants were screened for their potential α-glucosidase inhibitory activity.
  
  
  METHODS
  The 80% aqueous ethanolic extracts were screened for their α-glucosidase enzyme inhibitory activity using yeast alpha glucosidase enzyme.
  
  
  RESULTS
  Except for A. bilimbi with IC(50) at 519.86±3.07, all manifested a significant enzyme inhibitory activity. R. mucronata manifested the highest activity with IC(50) at 0.08±1.82 μg mL(-1), followed by C. tagal with IC(50) at 0.85±1.46 μg mL(-1) and B. sensitivum with IC(50) at 2.24±1.58 μg mL(-1).
  
  
  CONCLUSIONS
  This is the first report on the α-glucosidase inhibitory effect of the six Philippine plants; thus, partly defining the mechanism on why these medicinal plants possess antidiabetic properties.
authors.affiliation: Graduate School, University of Santo Tomas, España, Manila, Philippines.
authors.forename: Ivan L
authors.initials: IL
authors.lastname: Lawag
authors.forename: Alicia M
authors.initials: AM
authors.lastname: Aguinaldo
authors.forename: Suad
authors.initials: S
authors.lastname: Naheed
authors.forename: Mohammad
authors.initials: M
authors.lastname: Mosihuzzaman
mesh_terms: D003920:Diabetes Mellitus / Q000188:drug therapy; D004791:Enzyme Inhibitors / Q000494:pharmacology*; D065089:Glycoside Hydrolase Inhibitors; D019684:Magnoliopsida; D010679:Philippines; D035261:Plant Components, Aerial; D010936:Plant Extracts / Q000494:pharmacology*; D018517:Plant Roots; D010946:Plants, Medicinal
chemical_list: D004791:Enzyme Inhibitors; D065089:Glycoside Hydrolase Inhibitors; D010936:Plant Extracts