title: The pregnancy rate and live birth rate after kidney transplantation: a single-center experience.
abstract: Kidney transplantation is the treatment of choice for end-stage renal disease (ESRD). Kidney transplantation recipients live longer and have better quality of life than patients on dialysis. Hypothalamic gonadal dysfunction in females who have ESRD may be reversed within the first few months after kidney transplantation, such as the ability to have children. Despite thousands of successful pregnancies in transplantation recipients, there is limited information about it. In this study, we evaluated the pregnancy rates and live birth rates in women (n = 133) who underwent kidney transplantation in our center from 1983 to 2010. Recipients of a second kidney transplantation and recipients of multiorgan transplantations were excluded. We observed 33 pregnancies with 11 live births (33.3%), 12 spontaneous abortions (36.36%), and 10 therapeutic abortions (30.3%). The pregnancy rate was 18%. The live birth rate was 33.3%. Therapeutic abortions were 36.3%, and the pregnancies resulting in fetal loss were 30.3%. The pregnancies were identified in 32 women. The majority of women (n = 32; 96.9%) had a single pregnancy, whereas 1 woman (3.1%) had two pregnancies. In our series, the pregnancy rates for kidney transplantation recipients were markedly lower and decreased more rapidly than those reported in the general population.
authors.affiliation: General Surgery and Organ Transplantation Unit, IRCCS San Martino University Hospital, IST National Institute for Cancer Research, Genoa, Italy. iris.fontana@hsanmartino.it
authors.forename: I
authors.initials: I
authors.lastname: Fontana
authors.forename: G
authors.initials: G
authors.lastname: Santori
authors.forename: F
authors.initials: F
authors.lastname: Fazio
authors.forename: U
authors.initials: U
authors.lastname: Valente
mesh_terms: D005260:Female; D006801:Humans; D016030:Kidney Transplantation; D011247:Pregnancy; D011256:Pregnancy Outcome; D018873:Pregnancy Rate