title: Successful long-time treatment with mycophenolate-mofetil in a child with acquired factor VIII inhibitor.
abstract: Here, we report about a boy (age: 18 years) who developed an acquired factor VIII inhibitor at the age of 9 years. He presented with bleeding in his right ankle, multiple haematomas and a high-titer factor VIII type II inhibitor (400 BU).
  
  
  METHODS
  He received treatment with MMF (CellCept®), dexamethasone-immunoglobulin pulses, and rituximab together with high dose FVIII (Hannover protocol). His inhibitor titer decreased rapidly, and half-life and recovery normalized. Inhibitor titres increased after reduction of the factor VIII dose, and increased further after MMF was stopped. A second treatment course with MMF again resulted in reduction of the titre, improvement in half life and recovery, and no more bleedings. Inhibitor reappeared with MMF dose reduction, again accompanied by severe bleeding. Additional rituximab stopped the bleedings, and treatment with MMF has been continued since.
  
  
  CONCLUSIONS
  Although the laboratory parameters showed no complete remission, severe bleedings and expensive factor replacement could be avoided by long-term treatment with MMF.
authors.affiliation: Department of Paediatric Haematology and Oncology, Medical School Hannover, Hannover, Germany. wermes.cornelia@mh-hannover.de
authors.forename: C
authors.initials: C
authors.lastname: Wermes
authors.forename: C
authors.initials: C
authors.lastname: Niekrens
authors.forename: K-W
authors.initials: KW
authors.lastname: Sykora
mesh_terms: D000293:Adolescent; D019774:Blood Coagulation Factor Inhibitors / Q000097:blood*; D005169:Factor VIII / Q000037:antagonists & inhibitors*; D006467:Hemophilia A / Q000097:blood* / Q000188:drug therapy* / Q000517:prevention & control; D006801:Humans; D007166:Immunosuppressive Agents / Q000008:administration & dosage; D008137:Longitudinal Studies; D008297:Male; D009173:Mycophenolic Acid / Q000008:administration & dosage / Q000031:analogs & derivatives*; D016896:Treatment Outcome
chemical_list: D019774:Blood Coagulation Factor Inhibitors; D007166:Immunosuppressive Agents; D005169:Factor VIII; D009173:Mycophenolic Acid