title: Thrombophilia and venous thromboembolism: RIETE experience.
abstract: RIETE is an ongoing registry of consecutive patients with acute venous thromboembolism (VTE). First we learned that in RIETE the prevalence of positive tests was 32%. One in every 2 patients younger than 50 years tested positive, with no differences between idiopathic or secondary, first event or recurrent VTE. In contrast, one in every 4 patients older than 50 years tested positive. Then, we found that the younger age of women with factor V Leiden or prothrombin G20210A may be attributed to the higher proportion of women who had the VTE during pregnancy or contraceptive use. At variance with this, 60% of men had idiopathic VTE, and only those with factor V Leiden were younger than those who tested negative. We need more patients, more data and a longer follow-up. In a near future we might be able to learn more about the outcome of VTE patients.
authors.affiliation: Department of Internal Medicine, Hospital Universitari Germans Trias i Pujol, Badalona, Spain. mmonreal.germanstrias@gencat.cat
authors.forename: Manuel
authors.initials: M
authors.lastname: Monreal
authors.forename: Raquel Del
authors.initials: RD
authors.lastname: Campo
authors.forename: Emmanouil
authors.initials: E
authors.lastname: Papadakis
mesh_terms: D000208:Acute Disease; D000328:Adult; D000367:Age Factors; D003276:Contraceptives, Oral / Q000009:adverse effects; D005165:Factor V / Q000032:analysis*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009154:Mutation; D011247:Pregnancy; D011516:Prothrombin / Q000032:analysis / Q000235:genetics; D012042:Registries; D012737:Sex Factors; D019851:Thrombophilia / Q000150:complications / Q000175:diagnosis* / Q000209:etiology; D054556:Venous Thromboembolism / Q000175:diagnosis* / Q000209:etiology / Q000473:pathology
chemical_list: D003276:Contraceptives, Oral; C095381:factor V Leiden; D005165:Factor V; D011516:Prothrombin