title: [Effects of different neuromediators and regulatory peptides on the impulse activity of inferior vestibular nucleus neurons].
abstract: Microelectrode techniques and microionophoresis of physiologically active substances were used in experiments with cats to show the ability of classic neuromediators (L-glutamate, L-aspartate, acetylcholine, noradrenaline, gamma-aminobutyric acid (GABA), glycine and others) and regulatory peptides (enkephalines, TRH, substance P, vasoactive interstitial peptide (VIP), somatostatin (SS) and others) to influence directly the majority (60 to 100%) of neurons in the inferior vestibular nucleus (IVN). The inhibitory effect of enkephalines, VIP and SS on the neurons impulse activity was virtually uncompromised on the background of L-glutamate activity. In addition, it was stated that enkephalines, VIP and SS are potent to augment the inhibitory effect of GABA and glycine. Consequently, these substances have the capability to act as IVN neuromediators and/or neuromodulators.
mesh_terms: D000818:Animals; D002415:Cats; D018698:Glutamic Acid / Q000378:metabolism; D007478:Iontophoresis; D008297:Male; D008839:Microelectrodes; D009474:Neurons / Q000378:metabolism; D018377:Neurotransmitter Agents / Q000378:metabolism*; D010455:Peptides / Q000378:metabolism*; D014726:Vestibular Nuclei / Q000378:metabolism*
chemical_list: D018377:Neurotransmitter Agents; D010455:Peptides; D018698:Glutamic Acid