title: -374 T/A polymorphism in RAGE gene is associated with onset of diabetes mellitus, atherosclerosis, and renal dysfunction in patients with hypertension.
abstract: Receptor of advanced glycation end products (RAGE) is reportedly linked with chronic inflammatory diseases due to aging or diabetes. The aim of this study was to show how -374 T/A RAGE has an impact on systemic vascular damage and renal function. The study subjects were a total of 468 essential hypertension patients from the Non-Invasive Atherosclerotic Evaluation in Hypertension (NOAH) study cohort. We prospectively examined the association of -374 T/A RAGE with their prognoses and investigated the correlation between -374 T/A RAGE and multiple clinical parameters. Kaplan-Meier analysis did not show a significant association of -374 T/A RAGE with total mortality or the prevalence of cardiovascular events. Carriers of the A allele showed a significantly higher prevalence of diabetes mellitus (DM) and lower estimated glomerular filtration rate (eGFR) than subjects without this allele. In subjects with DM, carriers of the A allele showed a significantly lower eGFR. These significant correlations were only seen in male subjects. Carriers of the A allele of -374 T/A RAGE show an independent risk of atherosclerosis and reduced renal function in male hypertensive patients with DM.
authors.affiliation: Department of Geriatric Medicine and Nephrology, Osaka University Graduate School of Medicine, Suita, Osaka, Japan.
authors.forename: Tatsuo
authors.initials: T
authors.lastname: Kawai
authors.forename: Kei
authors.initials: K
authors.lastname: Kamide
authors.forename: Norihisa
authors.initials: N
authors.lastname: Ito
authors.forename: Miyuki
authors.initials: M
authors.lastname: Onishi
authors.forename: Ryosuke
authors.initials: R
authors.lastname: Oguro
authors.forename: Yasushi
authors.initials: Y
authors.lastname: Takeya
authors.forename: Yuji
authors.initials: Y
authors.lastname: Tatara
authors.forename: Yoshihiro
authors.initials: Y
authors.lastname: Maekawa
authors.forename: Tomohiro
authors.initials: T
authors.lastname: Katsuya
authors.forename: Mitsuru
authors.initials: M
authors.lastname: Ohishi
authors.forename: Hiromi
authors.initials: H
authors.lastname: Rakugi
mesh_terms: D000368:Aged; D000483:Alleles; D050197:Atherosclerosis / Q000150:complications / Q000235:genetics*; D015331:Cohort Studies; D048909:Diabetes Complications / Q000235:genetics*; D003920:Diabetes Mellitus / Q000235:genetics*; D005260:Female; D005838:Genotype; D005919:Glomerular Filtration Rate / Q000235:genetics; D006801:Humans; D006973:Hypertension / Q000150:complications / Q000235:genetics*; D053208:Kaplan-Meier Estimate; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D011446:Prospective Studies; D000067759:Receptor for Advanced Glycation End Products; D011971:Receptors, Immunologic / Q000235:genetics*; D051436:Renal Insufficiency, Chronic / Q000150:complications / Q000235:genetics*; D012737:Sex Factors
chemical_list: D000067759:Receptor for Advanced Glycation End Products; D011971:Receptors, Immunologic