title: Setting sail for glucose homeostasis with the AKAP150-PP2B-anchor.
abstract: Glucose-stimulated insulin secretion, controlled by multiple protein phosphorylation events, is critical for the regulation of glucose homeostasis. Protein kinase A (PKA) is known to play a role in β cell physiology, but the role of its anchoring protein is not fully understood. Hinke et al (2012) illustrate the significance of A-kinase anchoring protein 150 in tethering protein phosphatase 2B to mediate nutrient-stimulated insulin secretion and thus modulate glucose homeostasis.
authors.affiliation: Section of Islet Cell Biology and Regenerative Medicine, Joslin Diabetes Center and Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
authors.forename: Adrian Kee Keong
authors.initials: AK
authors.lastname: Teo
authors.forename: Rohit N
authors.initials: RN
authors.lastname: Kulkarni
mesh_terms: D054758:A Kinase Anchor Proteins / Q000502:physiology*; D000818:Animals; D005947:Glucose / Q000378:metabolism*; D006706:Homeostasis / Q000502:physiology*; D007333:Insulin Resistance / Q000235:genetics*; D008297:Male; D008565:Membrane Proteins / Q000502:physiology*; D010749:Phosphoprotein Phosphatases / Q000502:physiology*
chemical_list: D054758:A Kinase Anchor Proteins; C520665:Akap5 protein, mouse; D008565:Membrane Proteins; D010749:Phosphoprotein Phosphatases; D005947:Glucose