title: Sensitive detection of rutin with novel ferrocene benzyne derivative modified electrodes.
abstract: A new ferrocene benzyne derivative (Fc-SAc) that contained oligo-(phenylene-ethynylene) skeleton, ferrocene and thiolate terminal groups was firstly synthesized. The hydrolysis product of Fc-SAc (Fc-SH) was immobilized onto gold nanoparticles (AuNPs) modified glass carbon electrode (GCE) as sensing element for rutin detection with high sensitivity. The new sensing strategy was proposed by using two Fc-SH modified electrodes: Fc-S/AuNPs/GCE (Electrode1) and Fc-S/AuNPs/graphene-chitosan/GCE (Electrode2). The electrochemical oxidation of rutin on Electrode2 was a diffusion-controlled process, which was different from a mass-controlled process on Electrode1. Under the optimal conditions, the peak currents of the sensors were linearly related to the concentrations of rutin. The linear responses ranges were 0.05-30 μM and 0.04-100 μM with the regression coefficients of 0.998 and 0.997 on Electrode1 and Electrode2, respectively. Electrode2 presented wider linear range, superior high sensitivity, lower detection limit and better stability on determination of rutin.
authors.affiliation: Key Laboratory of Chemical Biology & Traditional Chinese Medicine Research (Ministry of Education, China), College of Chemistry and Chemical Engineering, Hunan Normal University, Changsha 410081, PR China.
authors.forename: Meiling
authors.initials: M
authors.lastname: Liu
authors.forename: Jianhui
authors.initials: J
authors.lastname: Deng
authors.forename: Qiong
authors.initials: Q
authors.lastname: Chen
authors.forename: Yan
authors.initials: Y
authors.lastname: Huang
authors.forename: Linping
authors.initials: L
authors.lastname: Wang
authors.forename: Yan
authors.initials: Y
authors.lastname: Zhao
authors.forename: Youyu
authors.initials: Y
authors.lastname: Zhang
authors.forename: Haitao
authors.initials: H
authors.lastname: Li
authors.forename: Shouzhuo
authors.initials: S
authors.lastname: Yao
mesh_terms: D001554:Benzene / Q000737:chemistry*; D015374:Biosensing Techniques / Q000295:instrumentation*; D003217:Conductometry / Q000295:instrumentation*; D004566:Electrodes; D004867:Equipment Design; D019544:Equipment Failure Analysis; D005296:Ferrous Compounds / Q000737:chemistry*; D006046:Gold / Q000737:chemistry; D053768:Metal Nanoparticles / Q000737:chemistry*; D000075163:Metallocenes; D015203:Reproducibility of Results; D012431:Rutin / Q000032:analysis* / Q000737:chemistry; D012680:Sensitivity and Specificity
chemical_list: D005296:Ferrous Compounds; D000075163:Metallocenes; D012431:Rutin; D006046:Gold; D001554:Benzene; C004998:ferrocene