title: Medical and surgical management of esophageal and gastric motor dysfunction.
abstract: he occurrence of esophageal and gastric motor dysfunctions happens, when the software of the esophagus and the stomach is injured. This is really a program previously established in the enteric nervous system as a constituent of the newly called neurogastroenterology. The enteric nervous system is composed of small aggregations of nerve cells, enteric ganglia, the neural connections between these ganglia, and nerve fibers that supply effectors tissues, including the muscle of the gut wall. The wide range of enteric neuropathies that includes esophageal achalasia and gastroparesis highlights the importance of the enteric nervous system. A classification of functional gastrointestinal disorders based on symptoms has received attention. However, a classification based solely in symptoms and consensus may lack an integral approach of disease. As an alternative to the Rome classification, an international working team in Bangkok presented a classification of motility disorders as a physiology-based diagnosis. Besides, the Chicago Classification of esophageal motility was developed to facilitate the interpretation of clinical high-resolution esophageal pressure topography studies. This review covers exclusively the medical and surgical management of the esophageal and gastric motor dysfunction using evidence from well-designed studies. Motor control of the esophagus and the stomach, motor esophageal and gastric alterations, treatment failure, side effects of PPIs, overlap of gastrointestinal symptoms, predictors of treatment, burden of GERD medical management, data related to conservative treatment vs. antireflux surgery, and postsurgical esophagus and gastric motor dysfunction are also taken into account.
authors.affiliation: Experimental Medicine and Motility Unit, Gastroenterology Service U-107, Mexico City General Hospital, 06726 México, DF, México. awadrichardalexander@prodigy.net.mx
authors.forename: R A
authors.initials: RA
authors.lastname: Awad
mesh_terms: D004377:Dumping Syndrome / Q000503:physiopathology / Q000628:therapy; D017615:Enteric Nervous System / Q000503:physiopathology; D004931:Esophageal Achalasia / Q000503:physiopathology / Q000628:therapy; D015154:Esophageal Motility Disorders / Q000145:classification / Q000175:diagnosis / Q000503:physiopathology* / Q000628:therapy*; D018662:Fundoplication; D005764:Gastroesophageal Reflux / Q000503:physiopathology / Q000628:therapy; D018589:Gastroparesis / Q000175:diagnosis / Q000503:physiopathology* / Q000628:therapy*; D006801:Humans; D010535:Laparoscopy / Q000379:methods; D008019:Life Style; D054328:Proton Pump Inhibitors / Q000008:administration & dosage / Q000009:adverse effects; D016032:Randomized Controlled Trials as Topic; D012307:Risk Factors; D016896:Treatment Outcome
chemical_list: D054328:Proton Pump Inhibitors