title: Ghrelin and obestatin expression in serous ovarian tumours.
abstract: OBJECTIVE
  To investigate ghrelin and obestatin expression in serous ovarian tumours.
  
  
  METHODS
  Preparations of deparaffinized blocks obtained from the pathology archives of a total of 47 previously diagnosed cases of benign serous tumour (n = 20), borderline serous tumour (n = 7) and malignant serous tumour (n = 20) were subjected to immunohistochemical examination to find out ghrelin and obestatin expressions.
  
  
  RESULTS
  Mean ghrelin expressions decreased significantly in the benign group, relative to the malignant group (p < 0.05), while there was no significant change in mean obestatin expression. It was established that rates of preparations with moderate and severe ghrelin and obestatin expression displayed a significant increase from benign to malignant ones (p < 0.05).
  
  
  CONCLUSIONS
  The fact that rates of preparations with severe expression correlated with an increase in malignancy suggests that ghrelin and obestatin may be effective in the malignant transformation in at least some cases.
authors.affiliation: Division of Gynecologic Oncology, Department of Obstetric and Gynecology, Firat University Medical School, Elazig, Turkey. cnurkalen@yahoo.com
authors.forename: Cemile
authors.initials: C
authors.lastname: Nurkalem
authors.forename: Husnu
authors.initials: H
authors.lastname: Celik
authors.forename: Ferda
authors.initials: F
authors.lastname: Dagli
authors.forename: Bilgin
authors.initials: B
authors.lastname: Gurates
authors.forename: Burcin
authors.initials: B
authors.lastname: Kavak
authors.forename: Zeynep
authors.initials: Z
authors.lastname: Dogan
authors.forename: Yakup
authors.initials: Y
authors.lastname: Baykus
authors.forename: Suleyman
authors.initials: S
authors.lastname: Aydin
mesh_terms: D000328:Adult; D000368:Aged; D015992:Body Mass Index; D002471:Cell Transformation, Neoplastic / Q000378:metabolism; D005260:Female; D005500:Follow-Up Studies; D054439:Ghrelin / Q000378:metabolism*; D006801:Humans; D007150:Immunohistochemistry; D008875:Middle Aged; D009363:Neoplasm Proteins / Q000378:metabolism*; D009364:Neoplasm Recurrence, Local; D009367:Neoplasm Staging; D010051:Ovarian Neoplasms / Q000378:metabolism* / Q000473:pathology; D012189:Retrospective Studies
chemical_list: C515349:GHRL protein, human; D054439:Ghrelin; D009363:Neoplasm Proteins; C505799:obestatin, human