title: 2,2',3,5',6-Pentachlorobiphenyl (PCB 95) and its hydroxylated metabolites are enantiomerically enriched in female mice.
abstract: Epidemiological and laboratory studies link polychlorinated biphenyls and their metabolites to adverse neurodevelopmental outcomes. Several neurotoxic PCB congeners are chiral and undergo enantiomeric enrichment in mammalian species, which may modulate PCB developmental neurotoxicity. This study measures levels and enantiomeric enrichment of PCB 95 and its hydroxylated metabolites (OH-PCBs) in adult female C57Bl/6 mice following subchronic exposure to racemic PCB 95. Tissue levels of PCB 95 and OH-PCBs increased with increasing dose. Dose-dependent enantiomeric enrichment of PCB 95 was observed in brain and other tissues. OH-PCBs also displayed enantiomeric enrichment in blood and liver, but were not detected in adipose and brain. In light of data suggesting enantioselective effects of chiral PCBs on molecular targets linked to PCB developmental neurotoxicity, our observations highlight the importance of accounting for PCB and OH-PCB enantiomeric enrichment in the assessment of PCB developmental neurotoxicity.
authors.affiliation: Department of Occupational and Environmental Health, College of Public Health, The University of Iowa, Iowa City, Iowa, USA.
authors.forename: Izabela
authors.initials: I
authors.lastname: Kania-Korwel
authors.forename: Christopher D
authors.initials: CD
authors.lastname: Barnhart
authors.forename: Marianna
authors.initials: M
authors.lastname: Stamou
authors.forename: Kim M
authors.initials: KM
authors.lastname: Truong
authors.forename: Mohammed H M E
authors.initials: MH
authors.lastname: El-Komy
authors.forename: Pamela J
authors.initials: PJ
authors.lastname: Lein
authors.forename: Peter
authors.initials: P
authors.lastname: Veng-Pedersen
authors.forename: Hans-Joachim
authors.initials: HJ
authors.lastname: Lehmler
mesh_terms: D000818:Animals; D004785:Environmental Pollutants / Q000378:metabolism* / Q000633:toxicity; D005260:Female; D006900:Hydroxylation; D051379:Mice; D008810:Mice, Inbred C57BL; D011078:Polychlorinated Biphenyls / Q000378:metabolism* / Q000633:toxicity; D013237:Stereoisomerism
chemical_list: D004785:Environmental Pollutants; C032904:2,2',3,5',6-pentachlorobiphenyl; D011078:Polychlorinated Biphenyls