title: Screening for symptoms of obstructive sleep apnea in children with severe craniofacial anomalies: assessment in a multidisciplinary unit.
abstract: OBJECTIVE
  To assess the incidence of airway obstruction symptoms and the presence of obstructive sleep apnea in children with severe craniofacial anomalies by a proactive screening program using a standard questionnaire and cardiorespiratory polygraphy.
  
  
  METHODS
  Children with severe craniofacial anomalies referred to our paediatric airway unit from February 2001 to June 2011 were eligible to be included in this retrospective, single centre study. Symptoms of airway obstruction were proactively investigated using the shorter version of the Pediatric Sleep Questionnaire (PSQ). Obstructive sleep apnea was assessed by means of cardiorespiratory polygraphy. Demographic data and reason for referral were also recorded. Primary outcomes were the prevalence of symptoms of airway obstruction and OSA.
  
  
  RESULTS
  44 children (24 girls) with severe craniofacial anomalies (15 Crouzon, 13 Apert, 9 Goldenhar, 5 Treacher-Collins, 2 Pfeiffer) were included, at a mean age of 5 years (range 8 months to 14 years). Reason for referral was routine follow up in 30 patients and overt OSA symptoms and signs in the remaining 14. PSQ results showed symptoms of airway obstruction in 82% of patients, being snoring the most frequent symptom (64.1%) followed by apneas (33.3%). Polygraphic studies showed inconclusive results in 8 children (18.2%), normal apnea-hypopnea index (AHI) in 16 (36.4%), mild obstructive sleep apnea in 9 (20.4%), moderate in 4 (9.1%) and severe obstructive sleep apnea in 7 (15.9%).
  
  
  CONCLUSIONS
  Children with craniofacial anomalies have a high prevalence of symptoms of airway obstruction and obstructive sleep apnea that support a proactive screening strategy in this highly selected population.
authors.affiliation: Pediatric Airway Unit, Division of Pediatric Pulmonology and Division of Pediatric Surgery, Hospital Universitario "12 de Octubre", Universidad Complutense de Madrid, Madrid, Spain. cluna.hdoc@salud.madrid.org
authors.forename: Carmen
authors.initials: C
authors.lastname: Luna-Paredes
authors.forename: Juan L
authors.initials: JL
authors.lastname: Antón-Pacheco
authors.forename: Gloria
authors.initials: G
authors.lastname: García Hernández
authors.forename: Antonio
authors.initials: A
authors.lastname: Martínez Gimeno
authors.forename: Ana I
authors.initials: AI
authors.lastname: Romance García
authors.forename: Ignacio I
authors.initials: II
authors.lastname: García Recuero
mesh_terms: D000293:Adolescent; D017677:Age Distribution; D002648:Child; D002675:Child, Preschool; D015331:Cohort Studies; D015897:Comorbidity; D019465:Craniofacial Abnormalities / Q000175:diagnosis* / Q000453:epidemiology*; D005260:Female; D006776:Hospitals, Pediatric; D006801:Humans; D007223:Infant; D008297:Male; D008403:Mass Screening / Q000379:methods; D017286:Polysomnography / Q000379:methods; D015995:Prevalence; D011379:Prognosis; D012189:Retrospective Studies; D018570:Risk Assessment; D012720:Severity of Illness Index; D017678:Sex Distribution; D020181:Sleep Apnea, Obstructive / Q000175:diagnosis* / Q000453:epidemiology*; D013030:Spain / Q000453:epidemiology; D011795:Surveys and Questionnaires