title: Efficacy of homemade hemostatics of injected gelatin matrix for immediately treating blunt hepatic trauma in canine model without additional pressure.
abstract: OBJECTIVE
  To explore the efficacy of homemade hemostatics of injected gelatin matrix (HIGM) for immediately treating blunt hepatic trauma in canine model without additional pressure.
  
  
  METHODS
  A total of 27 commercial hybrid dogs underwent celiotomy to establish hepatic trauma model after general anesthesia. The dogs were prospectively randomized into 3 groups: the treatment group (n=9, with the direct application of homemade hemostat), the positive control group (n=9, with thrombin solution), and the negative control group (n=9, with 0.9% normal saline). Time to hemostasis and intra-abdominal blood loss were recorded, and heart rate (HR), mean arterial pressure (MAP), and hematological parameters were compared among these three groups. Gross examinations were performed 30 minutes after surgery.
  
  
  RESULTS
  Significantly shorter time to hemostasis [(1.20±0.33) min] and less blood loss [(47.22±8.61) ml] were observed in the treatment group than in control groups (P 0.05). No cases of bleeding occurred in any animals in the treatment group, and no signs of infection and adhesion formation were evident due to exposure to HIGM. Two cases in the positive control group (22.22%) were found to have rebleeding. All animals in the negative control group experienced visible bleeding.
  
  
  CONCLUSIONS
  HIGM is effective for controlling bleeding after hepatic trauma without the additional compression, and therefore may be valuable in field surgery.
authors.affiliation: Department of Ultrasound, General Hospital of Chinese PLA, Beijing, China.
authors.forename: Xia
authors.initials: X
authors.lastname: Xie
authors.forename: Jiang-ke
authors.initials: JK
authors.lastname: Tian
authors.forename: Teng-fei
authors.initials: TF
authors.lastname: Yu
authors.forename: Fa-qin
authors.initials: FQ
authors.lastname: Lv
authors.forename: Rong
authors.initials: R
authors.lastname: Wu
authors.forename: Yu-kun
authors.initials: YK
authors.lastname: Luo
authors.forename: Jie
authors.initials: J
authors.lastname: Tang
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D004285:Dogs; D005780:Gelatin / Q000008:administration & dosage*; D006490:Hemostatics / Q000008:administration & dosage*; D007267:Injections; D008099:Liver / Q000293:injuries*
chemical_list: D006490:Hemostatics; D005780:Gelatin