title: Protein biomarkers of alcohol abuse.
abstract: Alcohol abuse can lead to a number of health and social issues. Our current inability to accurately assess long-term drinking behaviors is an important obstacle to its diagnosis and treatment. Biomarkers for chronic alcohol consumption have made a number of important advances but have yet to become highly accurate and as accepted as objective tests for other diseases. Thus, there is a crucial need for the development of more sensitive and specific markers of alcohol abuse. Recent advancements in proteomic technologies have greatly increased the potential for alcohol abuse biomarker discovery. Here, the authors review established and novel protein biomarkers for long-term alcohol consumption and the proteomic technologies that have been used in their study.
authors.affiliation: Department of Pharmacology, Pennsylvania State University College of Medicine, 500 University Drive, Hershey, PA 17033, USA.
authors.forename: Mariana P
authors.initials: MP
authors.lastname: Torrente
authors.forename: Willard M
authors.initials: WM
authors.lastname: Freeman
authors.forename: Kent E
authors.initials: KE
authors.lastname: Vrana
mesh_terms: D000345:Affinity Labels / Q000737:chemistry; D000428:Alcohol Drinking / Q000009:adverse effects* / Q000097:blood; D020751:Alcohol-Induced Disorders / Q000473:pathology; D000437:Alcoholism / Q000175:diagnosis* / Q000378:metabolism; D015415:Biomarkers / Q000097:blood*; D051152:Clusterin / Q000097:blood; D016207:Cytokines / Q000097:blood; D020404:Glycerophospholipids / Q000097:blood; D006801:Humans; D020543:Proteome / Q000032:analysis*; D040901:Proteomics / Q000379:methods; D012680:Sensitivity and Specificity; D013997:Time Factors; D014168:Transferrin / Q000737:chemistry
chemical_list: D000345:Affinity Labels; D015415:Biomarkers; C495242:CLU protein, human; D051152:Clusterin; D016207:Cytokines; D020404:Glycerophospholipids; D020543:Proteome; D014168:Transferrin; C051521:phosphatidylethanol