title: Clinical effectiveness and safety of permissive hypercapnia.
abstract: Experimental and clinical data indicate that ventilator strategies with permissive hypercapnia may reduce lung injury by a variety of mechanisms. Seven randomized controlled trials in preterm neonates suggest that permissive hypercapnia started early, before the initiation of mechanical ventilation (in conjunction with continuous positive airway pressure), followed by prolonged permissive hypercapnia if mechanical ventilation is needed is an alternative to early ventilation and surfactant. Permissive hypercapnia may improve pulmonary outcomes and survival.
authors.affiliation: Department of Pediatrics, Rady Children's Hospital, University of California San Diego, 9500 Gilman Drive, MC 0735, La Jolla, CA 92093, USA.
authors.forename: Julie
authors.initials: J
authors.lastname: Ryu
authors.forename: Gabriel
authors.initials: G
authors.lastname: Haddad
authors.forename: Waldemar A
authors.initials: WA
authors.lastname: Carlo
mesh_terms: D001997:Bronchopulmonary Dysplasia / Q000517:prevention & control*; D006801:Humans; D006935:Hypercapnia; D007231:Infant, Newborn; D007234:Infant, Premature; D012121:Respiration, Artificial / Q000379:methods*; D012127:Respiratory Distress Syndrome, Newborn / Q000628:therapy*