title: Candida-associated gastric ulcer relapsing in a different position with a different appearance.
abstract: An 87-year-old, Japanese woman was shown to have a submucosal tumor-like lesion with a deep, central ulceration covered with thick, whitish exudate in the stomach. Biopsy showed Candida tropicalis but not Helicobacter pylori (H. pylori). She had no predisposing factors or history of peptic ulcers nor had taken non-steroidal anti-inflammatory drugs (NSAIDs), diagnosed with Candida-associated gastric ulcer. Though cured of the lesion, she developed another ulcer in a different position, in which Candida was demonstrated but H. pylori was undetectable. This is the first case of recurrent Candida-associated gastric ulcer in the world. Detected in both the original and recurrent lesions in an H. pylori-negative patient with no antecedent ulcers who had not taken NSAIDs, Candida is considered, contrary to the prevailing opinion, to play an etiologic role in ulcer formation.
authors.affiliation: Department of Internal Medicine, Tome Municipal Hospital of Toyosato, Tome, Miyagi 987-0364, Japan. kydosarnymai@aria.ocn.ne.jp
authors.forename: Kenji
authors.initials: K
authors.lastname: Sasaki
mesh_terms: D000369:Aged, 80 and over; D001706:Biopsy; D041022:Candida tropicalis; D002177:Candidiasis / Q000150:complications*; D005260:Female; D006801:Humans; D054328:Proton Pump Inhibitors / Q000627:therapeutic use; D012008:Recurrence; D013270:Stomach / Q000473:pathology; D013276:Stomach Ulcer / Q000188:drug therapy / Q000453:epidemiology* / Q000382:microbiology*; D016896:Treatment Outcome
chemical_list: D054328:Proton Pump Inhibitors