title: Organometallic ruthenium and osmium compounds of pyridin-2- and -4-ones as potential anticancer agents.
abstract: Organometallic Ru(II) compounds are among the most widely studied anticancer agents. Functionalizing metal centers with biomolecule-derived ligands has been shown to be a promising strategy to improve the antiproliferative activity of metal-based chemotherapeutics. Herein, the synthesis of a series of novel 3-hydroxypyridin-2-one-derived ligands and their M(II)(η(6)-p-cymene) half-sandwich complexes (M = Ru, Os) is described. The compounds were characterized by 1D- and 2D-NMR spectroscopy, and elemental analysis.
authors.affiliation: University of Vienna, Institute of Inorganic Chemistry, Waehringer Str. 42, AT-1090 Vienna.
authors.forename: Helena
authors.initials: H
authors.lastname: Henke
authors.forename: Wolfgang
authors.initials: W
authors.lastname: Kandioller
authors.forename: Muhammad
authors.initials: M
authors.lastname: Hanif
authors.forename: Bernhard K
authors.initials: BK
authors.lastname: Keppler
authors.forename: Christian G
authors.initials: CG
authors.lastname: Hartinger
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000737:chemistry*; D009942:Organometallic Compounds / Q000138:chemical synthesis / Q000737:chemistry*; D017892:Osmium Compounds / Q000737:chemistry*; D011728:Pyridones / Q000737:chemistry*; D012428:Ruthenium / Q000737:chemistry*
chemical_list: D000970:Antineoplastic Agents; D009942:Organometallic Compounds; D017892:Osmium Compounds; D011728:Pyridones; D012428:Ruthenium