title: Increased serum heat shock protein 27 antibody titers and prooxidant-antioxidant balance in patients with beta-thalassemia major.
abstract: OBJECTIVE
  Determination of the serum heat shock protein 27 (Hsp27) antibody titers and prooxidant-antioxidant balance (PAB) in patients with thalassemia as markers of cell and oxidative stress, respectively.
  
  
  METHODS
  Serum PAB and anti-Hsp27 antibody titers were measured in 140 patients with thalassemia major and 140 sex- and age-matched healthy volunteers.
  
  
  RESULTS
  A significantly higher serum PAB value was observed in patients in comparison to controls. In the patient group, anti-Hsp27 antibody titers were significantly higher than for the control group (p < 0.001). We found a weak negative correlation between anti-Hsp27 antibody concentrations and the PAB (p = 0.03), but these values were not correlated with serum superoxide dismutase activity in the thalassemic patients.
  
  
  CONCLUSIONS
  Increased levels of serum PAB and Hsp27 antibodies may be involved in the pathological consequences of β-thalassemia major and may contribute to the development of endothelial injury.
authors.affiliation: Blood Transfusion Research Center, High Institute for Research and Education in Transfusion Medicine, Bojnurd, Iran.
authors.forename: Elham
authors.initials: E
authors.lastname: Ghahremanlu
authors.forename: Abdollah
authors.initials: A
authors.lastname: Banihashem
authors.forename: Hamidreza
authors.initials: H
authors.lastname: Saber
authors.forename: Shima
authors.initials: S
authors.lastname: Tavallaie
authors.forename: Naghmeh
authors.initials: N
authors.lastname: Mirhosseini
authors.forename: Majid
authors.initials: M
authors.lastname: Ghayour-Mobarhan
authors.forename: Gordon A A
authors.initials: GA
authors.lastname: Ferns
mesh_terms: D000293:Adolescent; D000906:Antibodies / Q000097:blood*; D000975:Antioxidants / Q000378:metabolism*; D002648:Child; D003710:Demography; D005260:Female; D055551:HSP27 Heat-Shock Proteins / Q000276:immunology*; D006801:Humans; D008297:Male; D016877:Oxidants / Q000097:blood*; D013482:Superoxide Dismutase / Q000378:metabolism; D055815:Young Adult; D017086:beta-Thalassemia / Q000378:metabolism* / Q000473:pathology
chemical_list: D000906:Antibodies; D000975:Antioxidants; D055551:HSP27 Heat-Shock Proteins; D016877:Oxidants; D013482:Superoxide Dismutase