title: The photodynamic inactivation of Staphylococcus aureus in water using visible light with a new expanded porphyrin.
abstract: In this work, the results of the application of organic expanded porphyrins in the disinfection of water by the photodynamic inactivation (PDI) technique are presented. The photoinactivation properties of a novel, expanded porphyrin, namely 20-(4-carboxyphenyl)-2,13-dimethyl-3,12-diethyl-(22π) pentaphyrin (PCCox), were tested in the disinfection of water using Staphylococcus aureus as a Gram-positive bacteria model. The data showed that PCCox was effective against S. aureus bacteria at nanomolar concentrations. The variation with irradiation time and concentration was studied using both a multi-LED monochromatic light (λ = 470 nm) and an incandescent light bulb with a wide emission spectrum. A PCCox dosage of 5 μM was sufficient to achieve a 99.997% abatement of S. aureus within 1 h of 40 W/m(2) irradiation with monochromatic light (λ = 470 nm), whereas under the same conditions using irradiation with white light, the abatement was 99.9997%.
authors.affiliation: Department of Chemistry, Physics and Environment, University of Udine, Via del Cotonificio, 108, I-33100, Udine, Italy.
authors.forename: G
authors.initials: G
authors.lastname: Rossi
authors.forename: D
authors.initials: D
authors.lastname: Goi
authors.forename: C
authors.initials: C
authors.lastname: Comuzzi
mesh_terms: D004203:Disinfection / Q000379:methods; D008027:Light; D015394:Molecular Structure; D017319:Photosensitizing Agents / Q000737:chemistry / Q000494:pharmacology; D011166:Porphyrins / Q000737:chemistry / Q000494:pharmacology*; D013211:Staphylococcus aureus / Q000528:radiation effects*; D014871:Water Microbiology; D018508:Water Purification / Q000379:methods*
chemical_list: C576492:20-(4-carboxyphenyl)-2,13-dimethyl-3,12-diethyl-(22pi)pentaphyrin; D017319:Photosensitizing Agents; D011166:Porphyrins