title: Computational multiscale modeling of embryo development.
abstract: Recent advances in live imaging and genetics of mammalian development which integrate observations of biochemical activity, cell-cell signaling and mechanical interactions between cells pave the way for predictive mathematical multi-scale modeling. In early mammalian embryo development, two of the most critical events which lead to tissue patterning involve changes in gene expression as well as mechanical interactions between cells. We discuss the relevance of mathematical modeling of multi-cellular systems and in particular in simulating these patterns and describe some of the technical challenges one encounters. Many of these issues are not unique for the embryonic system but are shared by other multi-cellular modeling areas.
authors.affiliation: Computational Biology and Biological Physics, Lund University, Lund, Sweden.
authors.forename: Pawel
authors.initials: P
authors.lastname: Krupinski
authors.forename: Vijay
authors.initials: V
authors.lastname: Chickarmane
authors.forename: Carsten
authors.initials: C
authors.lastname: Peterson
mesh_terms: D000818:Animals; D019521:Body Patterning / Q000235:genetics*; D002450:Cell Communication; D003198:Computer Simulation; D047108:Embryonic Development / Q000235:genetics*; D008322:Mammals / Q000235:genetics / Q000254:growth & development*; D008962:Models, Theoretical; D015398:Signal Transduction; D049490:Systems Biology