title: Rosette-forming glioneuronal tumor -- evidence of stem cell origin with biphenotypic differentiation.
abstract: Rosette-forming glioneuronal tumor (RGNT) of the fourth ventricle is a new addition to the WHO classification of central nervous system tumors. To date, 72 cases have been described in literature. In the present study, we report the clinical and imaging features, with detailed histopathological and immunohistochemical profile, of eight cases. Confocal microscopic evidence of stem cell origin with biphenotypic, glial and neurocytic differentiation is presented with a comprehensive review of literature.
authors.affiliation: Department of Pathology, Kasturba Medical College, Mangalore, Karnataka, India.
authors.forename: S
authors.initials: S
authors.lastname: Chakraborti
authors.forename: A
authors.initials: A
authors.lastname: Mahadevan
authors.forename: A
authors.initials: A
authors.lastname: Govindan
authors.forename: A
authors.initials: A
authors.lastname: Bhateja
authors.forename: S
authors.initials: S
authors.lastname: Dwarakanath
authors.forename: H R
authors.initials: HR
authors.lastname: Aravinda
authors.forename: A A
authors.initials: AA
authors.lastname: Phalguni
authors.forename: V
authors.initials: V
authors.lastname: Santosh
authors.forename: T C
authors.initials: TC
authors.lastname: Yasha
authors.forename: P
authors.initials: P
authors.lastname: Rout
authors.forename: S
authors.initials: S
authors.lastname: Sampath
authors.forename: S K
authors.initials: SK
authors.lastname: Shankar
mesh_terms: D000293:Adolescent; D000328:Adult; D014408:Biomarkers, Tumor / Q000378:metabolism; D001932:Brain Neoplasms / Q000378:metabolism / Q000473:pathology*; D002648:Child; D005260:Female; D018303:Ganglioglioma / Q000378:metabolism / Q000473:pathology*; D006801:Humans; D007124:Immunoenzyme Techniques; D008279:Magnetic Resonance Imaging; D008297:Male; D018613:Microscopy, Confocal; D008875:Middle Aged; D014411:Neoplastic Stem Cells / Q000378:metabolism / Q000473:pathology*; D010641:Phenotype; D055815:Young Adult
chemical_list: D014408:Biomarkers, Tumor