title: Extranodal natural killer/T-cell lymphoma, nasal type: clinical and computed tomography findings in the head and neck region.
abstract: OBJECTIVE
  In patients with nasal natural killer/T-cell lymphoma (NKTL), it is commonly without an obvious mass found in the nasal cavity by clinical or computed tomography (CT) findings. As a result, it takes longer to make a definite diagnosis when compared with other nasal malignancy. This study was designed to investigate clinical and CT findings of nasal NKTL.
  
  
  METHODS
  Forty-three patients with nasal NKTL were enrolled. The patients' data were collected retrospectively.
  
  
  METHODS
  All patients underwent contrast-enhanced CT scans and endoscopic examinations. Symptoms were noted and recorded in detail.
  
  
  RESULTS
  Patients with lymphoma limited to their nasal cavity or paranasal sinus (N/PN) presented symptoms similar to chronic rhinosinusitis, such as nasal obstruction and purulent nasal discharge. Patients with lymphoma of the nasopharynx or oropharynx (NPx/OPx) tended to present more frequently with epistaxis or blood-tinged sputum. On CT, NKTL was usually nonenhanced (79.1%), homogenous (100%), unilateral (61.9%), infiltrative (67.4%), and without central necrosis. Only 30.2% of the patients presented with a prominent mass. One disease-specific sign, different from patients with chronic rhinosinusitis, was that the mucosa of the nasal cavity was thickened without involvement of the mucosa of the paranasal sinus (40.6%).
  
  
  CONCLUSIONS
  The thickening of the mucosa of the nasal cavity without similar involvement of the paranasal sinuses is easily overlooked in patients with NKTL. In addition, the imaging findings of thickened mucosa of the nasal floor and/or nasal septum near the inferior meatus, a prominent mass, and bony destruction should raise suspicion of this diagnosis.
authors.affiliation: Department of Otolaryngology, Chang Gung Memorial Hospital and Chang Gung University, Taoyuan, Taiwan.
authors.forename: Liang-Yueh
authors.initials: LY
authors.lastname: Hung
authors.forename: Po-Hung
authors.initials: PH
authors.lastname: Chang
authors.forename: Ta-Jen
authors.initials: TJ
authors.lastname: Lee
authors.forename: Yin-Ping
authors.initials: YP
authors.lastname: Hsu
authors.forename: Yi-Wei
authors.initials: YW
authors.lastname: Chen
authors.forename: Chia-Hsiang
authors.initials: CH
authors.lastname: Fu
authors.forename: Chi-Che
authors.initials: CC
authors.lastname: Huang
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002648:Child; D003937:Diagnosis, Differential; D004724:Endoscopy; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D054391:Lymphoma, Extranodal NK-T-Cell / Q000000981:diagnostic imaging* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009296:Nasal Cavity / Q000000981:diagnostic imaging* / Q000473:pathology; D055611:Natural Killer T-Cells / Q000473:pathology*; D009669:Nose Neoplasms / Q000000981:diagnostic imaging* / Q000473:pathology; D012189:Retrospective Studies; D014057:Tomography, X-Ray Computed / Q000379:methods*; D055815:Young Adult