title: Prevalence of abnormal gastric emptying in asymptomatic women with newly detected diabetes and its reversibility after glycemic control-a prospective case control study.
abstract: OBJECTIVE
  Effects of systemic hyperglycemia and normoglycemia on gastric emptying in people with type 2 diabetes are not clear. The aim of the study was to investigate the gastric emptying time in people with newly detected diabetes before and after control of diabetes compared with healthy controls.
  
  
  METHODS
  Gastric emptying to solid meal was studied in 30 asymptomatic women with newly detected diabetes before and after achieving euglycemia and compared with 20 healthy age, sex and weight matched controls using egg white labelled with Technetium 99m Sulfur Colloid.
  
  
  RESULTS
  Delayed gastric emptying was seen in 90% of women with diabetes and none in healthy controls. Lag phase was 83.1±11.8 min in cases compared to 37.2±4.0 in controls (p=0.05). Gastric emptying at 4h was 46.73%±4.84% in cases and 97.65%±0.59% in controls (p=0.05).T50 was 250±8.8 min in cases against 94.70±5.10 min in controls (p<0.05). After control of diabetes, lag phase normalized to 37.2±4.0 min against 35.2±4.6 min in controls. Similarly all other parameters also normalized after control of diabetes.
  
  
  CONCLUSIONS
  Delayed gastric emptying to solids was seen in 90% of women with type 2 diabetes at the time of hyperglycemia and normalized after control of diabetes.
authors.affiliation: Department of Endocrinology, Sher-I-Kashmir Institute of Medical Sciences, Soura Srinagar, India.
authors.forename: Bashir Ahmad
authors.initials: BA
authors.lastname: Laway
authors.forename: Tajamul Syed
authors.initials: TS
authors.lastname: Malik
authors.forename: Shoukat Hussain
authors.initials: SH
authors.lastname: Khan
authors.forename: Tanveer Ahmad
authors.initials: TA
authors.lastname: Rather
mesh_terms: D000328:Adult; D058070:Asymptomatic Diseases; D001786:Blood Glucose / Q000187:drug effects / Q000378:metabolism; D016022:Case-Control Studies; D003924:Diabetes Mellitus, Type 2 / Q000150:complications / Q000188:drug therapy* / Q000503:physiopathology*; D004529:Egg White; D005260:Female; D005746:Gastric Emptying / Q000187:drug effects* / Q000502:physiology; D018589:Gastroparesis / Q000188:drug therapy* / Q000209:etiology / Q000503:physiopathology; D006801:Humans; D007004:Hypoglycemic Agents / Q000627:therapeutic use*; D007553:Isotope Labeling; D008875:Middle Aged; D015995:Prevalence; D011446:Prospective Studies; D013671:Technetium Tc 99m Sulfur Colloid; D013997:Time Factors
chemical_list: D001786:Blood Glucose; D007004:Hypoglycemic Agents; D013671:Technetium Tc 99m Sulfur Colloid