title: Determination of sedatives and adrenergic blockers in blood meal using accelerated solvent extraction and Orbitrap mass spectrometry.
abstract: The detection of veterinary drugs in blood meal is needed since it is used as an environment-friendly agricultural material despite its origination from animal blood. A method using accelerated solvent extraction and liquid chromatographic linear ion trap quadrupole Orbitrap mass spectrometry was developed to determine sedatives and adrenergic blockers in blood meal. The determination method was established following optimizations of accelerated solvent extraction, dispersive solid-phase extraction and high resolution mass spectrometric detection. Linearity, sensitivity, accuracy, repeatability and reproducibility of the method were fully validated. The method was applied to commercial blood meal products.
authors.affiliation: Institute of Environmental Research of the Faculty of Chemistry, Dortmund University of Technology, Otto-Hahn-Strasse 6, 44227 Dortmund, Germany.
authors.forename: Jeong-Heui
authors.initials: JH
authors.lastname: Choi
authors.forename: Marc
authors.initials: M
authors.lastname: Lamshöft
authors.forename: Sebastian
authors.initials: S
authors.lastname: Zühlke
authors.forename: Ki Hun
authors.initials: KH
authors.lastname: Park
authors.forename: Jae-Han
authors.initials: JH
authors.lastname: Shim
authors.forename: Michael
authors.initials: M
authors.lastname: Spiteller
mesh_terms: D018674:Adrenergic Antagonists / Q000032:analysis*; D000821:Animal Feed / Q000032:analysis*; D004350:Drug Residues / Q000032:analysis*; D005308:Fertilizers / Q000032:analysis; D006993:Hypnotics and Sedatives / Q000032:analysis*; D013058:Mass Spectrometry / Q000379:methods*; D011312:Pressure; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D052616:Solid Phase Extraction / Q000379:methods; D012997:Solvents; D013696:Temperature; D019155:Veterinary Drugs / Q000032:analysis*
chemical_list: D018674:Adrenergic Antagonists; D005308:Fertilizers; D006993:Hypnotics and Sedatives; D012997:Solvents; D019155:Veterinary Drugs