title: Effect of recombinant erythropoietin on functional activity of cultured human cells.
abstract: We studied the effect of recombinant human erythropoietin on functional activity of skin cells in vitro. It was found that erythropoietin stimulated proliferation of mesenchymal and epithelial cells and effectively protected epidermal HaCaT cells from apoptosis. Insignificant effect of erythropoietin on contraction of collagen gel by mesenchymal cells was revealed. These findings suggest that erythropoietin can be a promising component of wound-healing preparations.
authors.affiliation: N. K. Kol'tsov Institute of Developmental Biology, Russian Academy of Sciences, Moscow, Russia.
authors.forename: E A
authors.initials: EA
authors.lastname: Emel'yanova
authors.forename: A V
authors.initials: AV
authors.lastname: Kosykh
authors.forename: Yu V
authors.initials: YV
authors.lastname: Sukhanov
authors.forename: E A
authors.initials: EA
authors.lastname: Vorotelyak
authors.forename: A V
authors.initials: AV
authors.lastname: Vasil'ev
mesh_terms: D000273:Adipose Tissue / Q000187:drug effects*; D017209:Apoptosis / Q000187:drug effects*; D002460:Cell Line; D049109:Cell Proliferation / Q000187:drug effects*; D002478:Cells, Cultured; D003094:Collagen / Q000187:drug effects; D004847:Epithelial Cells / Q000187:drug effects; D004921:Erythropoietin / Q000494:pharmacology*; D005347:Fibroblasts / Q000187:drug effects; D005782:Gels; D006801:Humans; D020287:In Situ Nick-End Labeling; D015603:Keratinocytes / Q000187:drug effects; D008648:Mesoderm / Q000166:cytology / Q000187:drug effects*; D011994:Recombinant Proteins / Q000494:pharmacology*; D017154:Stromal Cells / Q000187:drug effects; D013997:Time Factors
chemical_list: D005782:Gels; D011994:Recombinant Proteins; D004921:Erythropoietin; D003094:Collagen