title: The combination of triiodothyronine (T3) and sertraline is not superior to sertraline monotherapy in the treatment of major depressive disorder.
abstract: OBJECTIVE
  To determine whether the combination of triiodothyronine (T3) plus sertraline at treatment initiation confers greater antidepressant efficacy than sertraline plus placebo in patients with major depressive disorder.
  
  
  METHODS
  Eight-week, double blind, randomized placebo controlled clinical trial of 153 adult outpatients between 18 and 60 years of age, with DSM-IV defined major depressive disorder. Patients were treated with sertraline flexibly adjusted for tolerability and in a double blind fashion with placebo or T3 (25 μg/day in week 1 and increasing to 50 μg/day in week 2). Response was defined categorically as 50% reduction and total score less than 15 in 21-item Hamilton Rating Scale for Depression (HRSD-21) at week 8 and remission as HRSD-21 less than 8.
  
  
  RESULTS
  There was no difference between treatment groups at final assessment; 65% of placebo and 61.8% of T3 treated subjects achieved response and 50.6% of placebo and 40.8% of T3 treated patients achieved remission. The mean daily dose at final assessment of sertraline and T3, respectively was 144.7 mg (± 48.7 mg) and 48.2 μg (± 7 μg). Median time to response did not differ between treatment groups. Baseline thyroid function tests did not predict response to sertraline treatment or T3 augmentation.
  
  
  CONCLUSIONS
  These results do not support the routine use of T3 to enhance or accelerate onset of antidepressant response in patients with major depressive disorder.
authors.affiliation: Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA 30322, USA. sgarlow@emory.edu
authors.forename: Steven J
authors.initials: SJ
authors.lastname: Garlow
authors.forename: Boadie W
authors.initials: BW
authors.lastname: Dunlop
authors.forename: Philip T
authors.initials: PT
authors.lastname: Ninan
authors.forename: Charles B
authors.initials: CB
authors.lastname: Nemeroff
mesh_terms: D000293:Adolescent; D000328:Adult; D003865:Major Depressive Disorder / Q000188:drug therapy*; D004311:Double-Blind Method; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D020280:Sertraline / Q000008:administration & dosage*; D012720:Severity of Illness Index; D016896:Treatment Outcome; D014284:Triiodothyronine / Q000008:administration & dosage*; D055815:Young Adult
chemical_list: D014284:Triiodothyronine; D020280:Sertraline