title: Effects of the CACNA1C risk allele on neurocognition in patients with schizophrenia and healthy individuals.
abstract: Recent genetic association studies have identified the A-allele of rs1006737 within CACNA1C as a risk factor for schizophrenia as well as mood disorders. Some evidence suggests that this polymorphism plays a role in cognitive function both in schizophrenia patients and healthy individuals; however, the precise nature of this association remains unclear. Here we investigated the possible association of this polymorphism with a wide range of neurocognitive functions in schizophrenia patients and in healthy subjects. Schizophrenia patients exhibited significantly poorer performance on all the cognitive domains as compared to healthy controls. In patients, A-allele carriers demonstrated significantly worse logical memory performance than the G-allele homozygotes. In controls, no significant association was observed between the genotype and any of the cognitive domains examined. These results add to the literature suggesting that rs1006737 may be associated with schizophrenia through its detrimental effect on endophenotypic traits.
authors.affiliation: Department of Mental Disorder Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Tokyo, Japan. hori@ncnp.go.jp
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Hori
authors.forename: Noriko
authors.initials: N
authors.lastname: Yamamoto
authors.forename: Takashi
authors.initials: T
authors.lastname: Fujii
authors.forename: Toshiya
authors.initials: T
authors.lastname: Teraishi
authors.forename: Daimei
authors.initials: D
authors.lastname: Sasayama
authors.forename: Junko
authors.initials: J
authors.lastname: Matsuo
authors.forename: Yumiko
authors.initials: Y
authors.lastname: Kawamoto
authors.forename: Yukiko
authors.initials: Y
authors.lastname: Kinoshita
authors.forename: Miho
authors.initials: M
authors.lastname: Ota
authors.forename: Kotaro
authors.initials: K
authors.lastname: Hattori
authors.forename: Masahiko
authors.initials: M
authors.lastname: Tatsumi
authors.forename: Kunimasa
authors.initials: K
authors.lastname: Arima
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Kunugi
mesh_terms: D000328:Adult; D000704:Analysis of Variance; D020746:Calcium Channels, L-Type / Q000235:genetics*; D016022:Case-Control Studies; D003071:Cognition; D005260:Female; D005787:Gene Frequency; D056726:Genetic Association Studies; D005838:Genotype; D006801:Humans; D008297:Male; D020641:Polymorphism, Single Nucleotide; D012559:Schizophrenia / Q000235:genetics*; D012565:Schizophrenic Psychology; D017422:Sequence Analysis, DNA
chemical_list: C079146:CACNA1C protein, human; D020746:Calcium Channels, L-Type