title: Leukocyte adhesion deficiency syndrome: report on the first case in Chile and South America.
abstract: BACKGROUND
  Adhesion molecule deficiency type 1 is a rare disease that should be suspected in any patient whose umbilical cord presents delay in falling off, and who presents recurrent severe infections. Early diagnostic suspicion and early treatment improve the prognosis.
  
  
  METHODS
  The case of a four-month-old boy with recurrent hospitalizations because of severe bronchopneumonia and several episodes of acute otitis media with non-purulent drainage of mucus and positive bacterial cultures is presented. His medical history included neonatal sepsis and delayed umbilical cord detachment. Laboratory studies showed marked leukocytosis with predominance of neutrophils and decreased CD11b and CD18. These were all compatible with a diagnosis of leukocyte adhesion deficiency type I [LAD type 1].
authors.affiliation: Department of Pediatrics, Campus Centro, Facultad de Medicina de la Universidad de Chile, Santiago, Chile. rvasquezk@gmail.com
authors.forename: Rodrigo
authors.initials: R
authors.lastname: Vásquez-De Kartzow
authors.forename: Cristian
authors.initials: C
authors.lastname: Jesam
authors.forename: Valentina
authors.initials: V
authors.lastname: Nehgme
authors.forename: Francisco
authors.initials: F
authors.lastname: Várgas
authors.forename: Carolina
authors.initials: C
authors.lastname: Sepúlveda
mesh_terms: D039481:CD11b Antigen / Q000097:blood; D018821:CD18 Antigens / Q000097:blood; D002677:Chile / Q000453:epidemiology; D006801:Humans; D007223:Infant; D018370:Leukocyte-Adhesion Deficiency Syndrome / Q000097:blood / Q000175:diagnosis* / Q000453:epidemiology; D008297:Male; D013020:South America / Q000453:epidemiology
chemical_list: D039481:CD11b Antigen; D018821:CD18 Antigens