title: Biotransformation of progesterone by Absidia griseolla var. igachii and Rhizomucor pusillus.
abstract: Biotransformation of progesterone using Absidia griseolla var. igachii and Rhizomucor pusillus strains as biocatalysts were investigated. Microbial hydroxylation of progesterone by A. griseolla produced two hydroxylated pregnane-like steroids. The metabolites identified as 6β,14α-dihydroxyprogesterone and 7α,14α-dihydroxyprogesterone. R. pusillus produced 6β,11α-dihydroxyprogesterone with excellent yield (65.5%) and 7α,14α-dihydroxyprogesterone. These metabolites were purified by TLC followed by their identification through (1)H, (13)C NMR and other spectroscopic data.
authors.affiliation: Department of Chemistry, Faculty of Science, Shahid Beheshti University, G.C., Tehran, Iran. z_habibi@sbu.ac.ir
authors.forename: Zohreh
authors.initials: Z
authors.lastname: Habibi
authors.forename: Maryam
authors.initials: M
authors.lastname: Yousefi
authors.forename: Shamim
authors.initials: S
authors.lastname: Ghanian
authors.forename: Mehdi
authors.initials: M
authors.lastname: Mohammadi
authors.forename: Sabrieh
authors.initials: S
authors.lastname: Ghasemi
mesh_terms: D020095:Absidia / Q000378:metabolism*; D001711:Biotransformation; D006900:Hydroxylation; D011374:Progesterone / Q000737:chemistry / Q000378:metabolism*; D020103:Rhizomucor / Q000378:metabolism*
chemical_list: D011374:Progesterone