title: Isolation of six new flavonoids from Melicope triphylla.
abstract: Six new flavonoids--5-hydroxy-3,8-dimethoxy-3',4':6,7-bismethylenedioxyflavone (1), 3,3',4',5-tetramethoxy-7-(3-methylbut-2-enyloxy)flavone (2), 7-(2-hydroxy-3-methylbut-3-enyloxy)-3,3',4',5-tetramethoxyflavone (3), 7-(2-hydroxy-3-methylbut-3-enyloxy)-3,5-dimethoxy-3',4'-methylenedioxyflavone (4), 7-(2-hydroxy-3-methylbut-3-enyloxy)-3,3',4',5,8-pentamethoxyflavone (5), and 7-(2-hydroxy-3-methylbut-3-enyloxy)-3,5,8-trimethoxy-3',4'-methylenedioxyflavone (6)--were isolated from the leaves of Melicope triphylla. In addition, six already known flavonoids were also detected: 5-hydroxy-3,6,7-trimethoxy-3',4'-methylenedioxyflavone (7), 5,7-dihydroxy-3,3',4',8-tetramethoxyflavone (8), 4',5-dihydroxy-3,3',7,8-tetramethoxyflavone (9), 3,5,6,7,8-pentamethoxy-3',4'-methylenedioxyflavone (10), 3,5,6,7-tetramethoxy-3',4'-methylenedioxyflavone (11), and 3,3',4',5,6,7,8-heptamethoxyflavone (12). The structures of the new compounds were established by spectroscopic methods. Compound 2 displayed ichthyotoxic activity against Japanese killifish (medaka in Japanese) (Oryzias latipes var.) at 10 ppm.
authors.affiliation: College of Science, University of The Ryukyus, Nishihara, Okinawa 903-0213, Japan. matuhiga@sci.u-ryukyu.ac.jp
authors.forename: Matsutake
authors.initials: M
authors.lastname: Higa
authors.forename: Megumi
authors.initials: M
authors.lastname: Imamura
authors.forename: Kanae
authors.initials: K
authors.lastname: Shimoji
authors.forename: Kazuhito
authors.initials: K
authors.lastname: Ogihara
authors.forename: Toshimasa
authors.initials: T
authors.lastname: Suzuka
mesh_terms: D005419:Flavonoids / Q000737:chemistry* / Q000302:isolation & purification*; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification; D018515:Plant Leaves / Q000737:chemistry*; D027821:Rutaceae / Q000737:chemistry*
chemical_list: D005419:Flavonoids; D010936:Plant Extracts