title: Excretion of himantane and its metabolites with the urine and feces in rats.
abstract: The levels of himantane and its metabolites in daily urine and feces of rats were measured after intraperitoneal and oral dose of 25 mg/kg. The injected dose of the initial substance and 1.3% its metabolites were eliminated with excrements within 24 h after administration via both routes 0.23%.
authors.affiliation: Laboratory of Pharmacokinetics, V. V. Zakusov Institute of Pharmacology, the Russian Academy of Medical Sciences, Moscow, Russia. zlanomar@gmail.com
authors.forename: E A
authors.initials: EA
authors.lastname: Litvin
authors.forename: D V
authors.initials: DV
authors.lastname: Bastrygin
authors.forename: G B
authors.initials: GB
authors.lastname: Kolyvanov
authors.forename: K V
authors.initials: KV
authors.lastname: Alekseyev
authors.forename: V P
authors.initials: VP
authors.lastname: Zherdev
mesh_terms: D000218:Adamantane / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000378:metabolism / Q000493:pharmacokinetics / Q000652:urine; D000284:Administration, Oral; D000818:Animals; D000978:Antiparkinson Agents / Q000008:administration & dosage / Q000378:metabolism* / Q000493:pharmacokinetics* / Q000652:urine; D001711:Biotransformation; D005243:Feces / Q000737:chemistry; D007274:Injections, Intraperitoneal; D013058:Mass Spectrometry; D051381:Rats; D013997:Time Factors
chemical_list: D000978:Antiparkinson Agents; C122112:N-(2-adamantyl)hexamethylenimine; D000218:Adamantane