title: KPNA3 variation is associated with schizophrenia, major depression, opiate dependence and alcohol dependence.
abstract: KPNA3 is a gene that has been linked to schizophrenia susceptibility. In this study we investigated the possible association between KPNA3 variation and schizophrenia. To investigate a wider role of KPNA3 across psychiatric disorders we also analysed major depression, PTSD, nicotine dependent, alcohol dependent and opiate dependent cohorts. Using a haplotype block-based gene-tagging approach we genotyped six KPNA3 single nucleotide polymorphisms (SNPs) in 157 schizophrenia patients, 121 post-traumatic stress disorder patients, 120 opiate dependent patients, 231 alcohol dependent patients, 147 nicotine dependent patients and 266 major depression patients. One SNP rs2273816 was found to be significantly associated with schizophrenia, opiate dependence and alcohol dependence at the genotype and allele level. Major depression was also associated with rs2273816 but only at the allele level. Our study suggests that KPNA3 may contribute to the genetic susceptibility to schizophrenia as well as other psychiatric disorders.
authors.affiliation: Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Queensland, Australia.
authors.forename: Charles P
authors.initials: CP
authors.lastname: Morris
authors.forename: Bernhard T
authors.initials: BT
authors.lastname: Baune
authors.forename: Katharina
authors.initials: K
authors.lastname: Domschke
authors.forename: Volker
authors.initials: V
authors.lastname: Arolt
authors.forename: Christopher D
authors.initials: CD
authors.lastname: Swagell
authors.forename: Ian P
authors.initials: IP
authors.lastname: Hughes
authors.forename: Bruce R
authors.initials: BR
authors.lastname: Lawford
authors.forename: Ross
authors.initials: R
authors.lastname: McD Young
authors.forename: Joanne
authors.initials: J
authors.lastname: Voisey
mesh_terms: D000328:Adult; D000437:Alcoholism / Q000235:genetics*; D016022:Case-Control Studies; D003866:Depressive Disorder / Q000235:genetics*; D005260:Female; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006239:Haplotypes; D006801:Humans; D008297:Male; D008875:Middle Aged; D009293:Opioid-Related Disorders / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D012559:Schizophrenia / Q000235:genetics*; D013313:Stress Disorders, Post-Traumatic / Q000235:genetics; D014029:Tobacco Use Disorder / Q000235:genetics; D028901:alpha Karyopherins / Q000235:genetics*
chemical_list: C106306:KPNA3 protein, human; D028901:alpha Karyopherins