title: SAPIN: a framework for the structural analysis of protein interaction networks.
abstract: CONCLUSIONS
  Protein interaction networks are widely used to depict the relationships between proteins. These networks often lack the information on physical binary interactions, and they do not inform whether there is incompatibility of structure between binding partners. Here, we introduce SAPIN, a framework dedicated to the structural analysis of protein interaction networks. SAPIN first identifies the protein parts that could be involved in the interaction and provides template structures. Next, SAPIN performs structural superimpositions to identify compatible and mutually exclusive interactions. Finally, the results are displayed using Cytoscape Web.
  
  
  BACKGROUND
  The SAPIN server is available at http://sapin.crg.es.
  
  
  BACKGROUND
  jae-seong.yang@crg.eu or christina.kiel@crg.eu.
  
  
  BACKGROUND
  Supplementary data are available at Bioinformatics Online.
authors.affiliation: EMBL/CRG, Design of Biological Systems, Systems Biology Research Unit, Centre for Genomic Regulation-CRG, UPF, 08003 Barcelona, Spain. jae-seong.yang@crg.eu
authors.forename: Jae-Seong
authors.initials: JS
authors.lastname: Yang
authors.forename: Anne
authors.initials: A
authors.lastname: Campagna
authors.forename: Javier
authors.initials: J
authors.lastname: Delgado
authors.forename: Peter
authors.initials: P
authors.lastname: Vanhee
authors.forename: Luis
authors.initials: L
authors.lastname: Serrano
authors.forename: Christina
authors.initials: C
authors.lastname: Kiel
mesh_terms: D006801:Humans; D025941:Protein Interaction Mapping; D060066:Protein Interaction Maps; D011506:Proteins / Q000737:chemistry* / Q000378:metabolism*; D020539:Sequence Analysis, Protein; D012984:Software
chemical_list: D011506:Proteins