title: Enantioselective synthesis of coumarin derivatives by PYBOX-DIPH-Zn(II) complex catalyzed Michael reaction.
abstract: A potential pharmacologically active chiral 3-substituted 4-hydroxy-2-oxo-2H-chromene skeleton has been synthesized by enantioselective Michael addition catalyzed by PYBOX-DIPH-Zn(OTf)(2) complex. The methodology has successfully been employed in the synthesis of (R)-Warfarin and another related compounds.
authors.affiliation: Department of Chemistry, Indian Institute of Technology Kanpur, Kanpur, Uttar Pradesh, 208 016, India.
authors.forename: Sumit K
authors.initials: SK
authors.lastname: Ray
authors.forename: Pradeep K
authors.initials: PK
authors.lastname: Singh
authors.forename: Nagaraju
authors.initials: N
authors.lastname: Molleti
authors.forename: Vinod K
authors.initials: VK
authors.lastname: Singh
mesh_terms: D001578:Benzopyrans / Q000138:chemical synthesis / Q000737:chemistry*; D002384:Catalysis; D003374:Coumarins / Q000138:chemical synthesis* / Q000737:chemistry; D058116:Lewis Acids / Q000737:chemistry*; D015394:Molecular Structure; D010080:Oxazoles / Q000737:chemistry*; D013237:Stereoisomerism; D017967:Zinc Compounds / Q000737:chemistry*
chemical_list: C578546:4-hydroxy-2-oxo-2H-chromene; D001578:Benzopyrans; D003374:Coumarins; D058116:Lewis Acids; D010080:Oxazoles; D017967:Zinc Compounds; C030123:coumarin