title: Orienting the direction of EGFR activation.
abstract: Morphogens are typically distributed symmetrically from their source of production. In this issue of Developmental Cell, Peng et al. (2012) demonstrate that a bias in the directionality of protrusions emanating from cells secreting the EGFR ligand Spitz leads to asymmetric activation of the pathway.
authors.affiliation: Department of Molecular Genetics, Weizmann Institute of Science, Rehovot 76100, Israel. benny.shilo@weizmann.ac.il
authors.forename: Ben-Zion
authors.initials: BZ
authors.lastname: Shilo
authors.forename: Eyal D
authors.initials: ED
authors.lastname: Schejter