title: Errors introduced by dose scaling for relative dosimetry.
abstract: Some dosimeters require a relationship between detector signal and delivered dose. The relationship (characteristic curve or calibration equation) usually depends on the environment under which the dosimeters are manufactured or stored. To compensate for the difference in radiation response among different batches of dosimeters, the measured dose can be scaled by normalizing the measured dose to a specific dose. Such a procedure, often called "relative dosimetry", allows us to skip the time-consuming production of a calibration curve for each irradiation. In this study, the magnitudes of errors due to the dose scaling procedure were evaluated by using the characteristic curves of BANG3 polymer gel dosimeter, radiographic EDR2 films, and GAFCHROMIC EBT2 films. Several sets of calibration data were obtained for each type of dosimeters, and a calibration equation of one set of data was used to estimate doses of the other dosimeters from different batches. The scaled doses were then compared with expected doses, which were obtained by using the true calibration equation specific to each batch. In general, the magnitude of errors increased with increasing deviation of the dose scaling factor from unity. Also, the errors strongly depended on the difference in the shape of the true and reference calibration curves. For example, for the BANG3 polymer gel, of which the characteristic curve can be approximated with a linear equation, the error for a batch requiring a dose scaling factor of 0.87 was larger than the errors for other batches requiring smaller magnitudes of dose scaling, or scaling factors of 0.93 or 1.02. The characteristic curves of EDR2 and EBT2 films required nonlinear equations. With those dosimeters, errors larger than 5% were commonly observed in the dose ranges of below 50% and above 150% of the normalization dose. In conclusion, the dose scaling for relative dosimetry introduces large errors in the measured doses when a large dose scaling is applied, and this procedure should be applied with special care.
authors.affiliation: Department of Therapeutic Radiology, University of Minnesota, Minneapolis, MN 55455, USA. watan016@umn.edu
authors.forename: Yoichi
authors.initials: Y
authors.lastname: Watanabe
authors.forename: Naoki
authors.initials: N
authors.lastname: Hayashi
mesh_terms: D002138:Calibration; D003951:Diagnostic Errors; D004307:Dose-Response Relationship, Radiation; D005373:Film Dosimetry / Q000295:instrumentation / Q000379:methods*; D005782:Gels / Q000737:chemistry*; D006801:Humans; D016014:Linear Models; D011108:Polymers / Q000737:chemistry*; D011880:Radiotherapy Planning, Computer-Assisted
chemical_list: D005782:Gels; D011108:Polymers