title: A new bioactive Schiff base ligands derived from propylazo-N-pyrimidin-2-yl-benzenesulfonamides Mn(II) and Cu(II) complexes: synthesis, thermal and spectroscopic characterization biological studies and 3D modeling structures.
abstract: New series of Schiff base ligand H(2)L and their Cu(II) and Mn(II) complexes derived from azosulfapyrimidine were synthesized and characterized by elemental and thermal studies conductance measurements IR, electronic and EPR spectra. 3D modeling of the ligand indicate that azo group does not participate in complex formation and surface potential on one of the ligand under study indicate that electron density around azomethine groups are much higher than the azo group therefore coordination takes place around azomethine groups. The variety in the geometrical structures depends on the nature of both the metal ions and the Schiff base ligands. The thermo kinetic parameters are calculated and discussed. The biological activities of the ligands and complexes have been screened in vitro against some bacteria and fungi to study their capacity to inhibit their growth and to study the toxicity of the compounds.
authors.affiliation: Department of Chemistry, Faculty of Education, Ain Shams University, Roxy, Cairo, Egypt.
authors.forename: Abdelrazak M
authors.initials: AM
authors.lastname: Tawfik
authors.forename: Mosad A
authors.initials: MA
authors.lastname: El-Ghamry
authors.forename: Samy M
authors.initials: SM
authors.lastname: Abu-El-Wafa
authors.forename: Naglaa M
authors.initials: NM
authors.lastname: Ahmed
mesh_terms: D000900:Anti-Bacterial Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D000935:Antifungal Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects; D056831:Coordination Complexes / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D003300:Copper / Q000737:chemistry / Q000494:pharmacology*; D004553:Electric Conductivity; D004578:Electron Spin Resonance Spectroscopy; D005658:Fungi / Q000187:drug effects; D008024:Ligands; D008345:Manganese / Q000737:chemistry / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D008958:Models, Molecular; D012545:Schiff Bases / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D013055:Spectrophotometry, Infrared; D013056:Spectrophotometry, Ultraviolet; D055672:Static Electricity; D013449:Sulfonamides / Q000737:chemistry*; D013696:Temperature; D013818:Thermogravimetry; D000096926:Benzenesulfonamides
chemical_list: D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D056831:Coordination Complexes; D003300:Copper; D008024:Ligands; D008345:Manganese; D012545:Schiff Bases; D013449:Sulfonamides; D000096926:Benzenesulfonamides