title: Electroanalytical and isothermal calorimetric study of As(III) complexation by the metal poisoning remediators, 2,3-dimercapto-1-propanesulfonate and meso-2,3-dimercaptosuccinic acid.
abstract: A recently developed methodology, which combines voltammetry, ITC, ESI-MS and several chemometric tools, has been applied for the first time to the study of As(III) complexes. The ligands considered, DMSA and DMPS, are commonly used to treat heavy metal poisoning. The study yields a reliable and consistent picture of the binding of As(III) by the chelating therapy agents DMSA and DMPS providing an unambiguous description of the stoichiometries of the complexes (ML(2), with the occasional appearance of ML in the case of DMSA), both ligands have stability constants of the same order, with a logβ(2) of 9.2 and 9.8, respectively. These values confirm the potential efficiency of both ligands in the treatment of As(III) poisoning.
authors.affiliation: Departament de Química Analítica, Universitat de Barcelona, Martí i Franquès, 1-11, E-08028 Barcelona, Spain.
authors.forename: Santiago
authors.initials: S
authors.lastname: Cavanillas
authors.forename: Elena
authors.initials: E
authors.lastname: Chekmeneva
authors.forename: Cristina
authors.initials: C
authors.lastname: Ariño
authors.forename: José Manuel
authors.initials: JM
authors.lastname: Díaz-Cruz
authors.forename: Miquel
authors.initials: M
authors.lastname: Esteban
mesh_terms: D001149:Arsenates / Q000032:analysis / Q000737:chemistry*; D020261:Arsenic Poisoning / Q000188:drug therapy; D002151:Calorimetry / Q000379:methods*; D002614:Chelating Agents / Q000737:chemistry* / Q000627:therapeutic use; D055664:Electrochemical Techniques; D000075322:Heavy Metal Poisoning; D006801:Humans; D016018:Least-Squares Analysis; D019216:Metals, Heavy / Q000037:antagonists & inhibitors; D016011:Normal Distribution; D011041:Poisoning; D021241:Spectrometry, Mass, Electrospray Ionization / Q000379:methods; D004113:Succimer / Q000737:chemistry* / Q000627:therapeutic use; D014494:Unithiol / Q000737:chemistry* / Q000627:therapeutic use
chemical_list: D001149:Arsenates; D002614:Chelating Agents; D019216:Metals, Heavy; D014494:Unithiol; D004113:Succimer