title: Aging-associated inflammation in healthy Japanese individuals and patients with Werner syndrome.
abstract: Minor inflammation-driven aging (inflammaging) has been proposed to explain human aging mechanism. To study the inflammatory condition associated with normal human aging, highly sensitive CRP (hsCRP) was examined in the sera collected from 217 healthy Japanese individuals aged between 1 and 100years and 41 mutation-proven Japanese Werner syndrome (WS) patients. The serum hsCRP was assayed by ELISA. The serum hsCRP level increased significantly (p<0.001) with normal aging from both sexes. The serum hsCRP was significantly elevated in WS (mean±SE: 11.0±1.6μg/ml) compared with age-matched normal population (1.3±0.3μg/ml, p<0.001) and normal elderly population ages between 71 and 100years (4.2±0.7μg/ml, p<0.001). Both normal aging and WS were associated with minor inflammation that can be evaluated by serum hsCRP. WS may be a good candidate to study inflammaging.
authors.affiliation: Division of Anti-Ageing and Longevity Sciences, Department of Medical Technology, Toin University of Yokohama, Japan. werner.goto@gmail.com
authors.forename: Makoto
authors.initials: M
authors.lastname: Goto
authors.forename: Kazunori
authors.initials: K
authors.lastname: Sugimoto
authors.forename: Seigaku
authors.initials: S
authors.lastname: Hayashi
authors.forename: Tetsuhito
authors.initials: T
authors.lastname: Ogino
authors.forename: Masanobu
authors.initials: M
authors.lastname: Sugimoto
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Furuichi
authors.forename: Masaaki
authors.initials: M
authors.lastname: Matsuura
authors.forename: Yuichi
authors.initials: Y
authors.lastname: Ishikawa
authors.forename: Sachiko
authors.initials: S
authors.lastname: Iwaki-Egawa
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Watanabe
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000375:Aging / Q000097:blood / Q000502:physiology*; D015415:Biomarkers / Q000097:blood; D002097:C-Reactive Protein / Q000378:metabolism; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007223:Infant; D007249:Inflammation / Q000097:blood / Q000150:complications / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D014898:Werner Syndrome / Q000097:blood / Q000150:complications / Q000503:physiopathology*; D055815:Young Adult
chemical_list: D015415:Biomarkers; D002097:C-Reactive Protein