title: [A case study; ethnicity and clozapine, a risky combination?].
abstract: Agranulocytosis is a very serious side-effect of treatment with clozapine. For this reason, the Dutch guidelines state the specific values of leukocyte and neutrophil counts at which treatment with clozapine should be discontinued. We focus on a patient with a benign ethnic neutropenia who, despite a low neutrophil count, was allowed to continue taking clozapine. We discuss a number of important practical considerations that can affect the way in which leukocyte and neutrophil counts are interpreted in relation to the use of clozapine.
authors.affiliation: w.laan@parnassia.nl
authors.forename: W J D M
authors.initials: WJ
authors.lastname: Laan
authors.forename: D
authors.initials: D
authors.lastname: Ramlal
mesh_terms: D000380:Agranulocytosis / Q000097:blood / Q000139:chemically induced* / Q000208:ethnology*; D014150:Antipsychotic Agents / Q000009:adverse effects* / Q000627:therapeutic use; D001772:Blood Cell Count; D003024:Clozapine / Q000009:adverse effects*; D006801:Humans; D007958:Leukocyte Count; D008297:Male; D009503:Neutropenia / Q000097:blood / Q000139:chemically induced; D009504:Neutrophils / Q000187:drug effects; D012559:Schizophrenia / Q000097:blood / Q000188:drug therapy; D055815:Young Adult
chemical_list: D014150:Antipsychotic Agents; D003024:Clozapine