title: Markers of inflammation and bone remodelling associated with improvement in clinical response measures in psoriatic arthritis patients treated with golimumab.
abstract: OBJECTIVE
  To determine serum biomarker associations with clinical response to golimumab treatment in patients with psoriatic arthritis (PsA).
  
  
  METHODS
  GO-REVEAL was a randomised, placebo-controlled study of golimumab in patients with active PsA. Samples were collected from 100 patients at baseline, week 4 and week 14, and analysed for serum-based biomarkers and protein profiling (total 92 markers); data were correlated with clinical measures at week 14.
  
  
  RESULTS
  Serum levels of a subset of proteins (apolipoprotein C III, ENRAGE, IL-16, myeloperoxidase, vascular endothelial growth factor, pyridinoline, matrix metalloproteinase 3, C-reactive protein (CRP), carcinoembryonic antigen, intercellular adhesion molecule 1 and macrophage inflammatory protein 1α) at baseline or week 4 were strongly associated with American College of Rheumatology 20% improvement (ACR20) response and/or disease activity score in 28 joints (DAS28) at week 14. A smaller subset of proteins was significantly associated with a 75% improvement in the psoriasis area and severity index score (PASI75) at week 14, (adiponectin, apolipoprotein CIII, serum glutamic oxaloacetic transaminase, and tumour necrosis factor α). Subsets of proteins were identified as potentially predictive of clinical response for each of the clinical measures, and the power of these biomarker panels to predict clinical response to golimumab treatment was stronger than for CRP alone.
  
  
  CONCLUSIONS
  This analysis provides insight into several panels of markers that may have utility in identifying PsA patients likely to have ACR20, DAS28, or PASI75 responses following golimumab treatment.
authors.affiliation: Department of Immunology, Janssen Research & Development, LLC, Spring House, PA, USA. cwagner@its.jnj.com
authors.forename: Carrie L
authors.initials: CL
authors.lastname: Wagner
authors.forename: Sudha
authors.initials: S
authors.lastname: Visvanathan
authors.forename: Michael
authors.initials: M
authors.lastname: Elashoff
authors.forename: Iain B
authors.initials: IB
authors.lastname: McInnes
authors.forename: Philip J
authors.initials: PJ
authors.lastname: Mease
authors.forename: Gerald G
authors.initials: GG
authors.lastname: Krueger
authors.forename: Frederick T
authors.initials: FT
authors.lastname: Murphy
authors.forename: Kim
authors.initials: K
authors.lastname: Papp
authors.forename: Juan J
authors.initials: JJ
authors.lastname: Gomez-Reino
authors.forename: Michael
authors.initials: M
authors.lastname: Mack
authors.forename: Anna
authors.initials: A
authors.lastname: Beutler
authors.forename: Dafna
authors.initials: D
authors.lastname: Gladman
authors.forename: Arthur
authors.initials: A
authors.lastname: Kavanaugh
mesh_terms: D000328:Adult; D000911:Antibodies, Monoclonal / Q000627:therapeutic use*; D018501:Antirheumatic Agents / Q000627:therapeutic use*; D015535:Arthritis, Psoriatic / Q000097:blood / Q000188:drug therapy*; D015415:Biomarkers / Q000097:blood*; D016723:Bone Remodeling / Q000187:drug effects*; D005260:Female; D006801:Humans; D007249:Inflammation / Q000097:blood* / Q000188:drug therapy; D008297:Male; D008875:Middle Aged
chemical_list: D000911:Antibodies, Monoclonal; D018501:Antirheumatic Agents; D015415:Biomarkers; C529000:golimumab