title: Asymmetric synthesis of a highly functionalized enantioenriched system close to thapsigargin framework.
abstract: A straightforward approach to a highly functionalized enantioenriched bicyclo[5.3.0]decadienone system close to the thapsigargin framework has been achieved. The developed synthetic route involves two main stages: installation of the chains on either side of the quaternary center at C7 starting from a central enantiopure epoxide and formation of the bicyclic octahydroazulene through subsequent Pauson-Khand annelation.
authors.affiliation: Faculté de Pharmacie, CNRS UMR 8638, Université Paris Descartes, 4 avenue de l'Observatoire, 75270 Paris Cedex 06, France.
authors.forename: Aurélien
authors.initials: A
authors.lastname: Tap
authors.forename: Morgan
authors.initials: M
authors.lastname: Jouanneau
authors.forename: Gilles
authors.initials: G
authors.lastname: Galvani
authors.forename: Geoffroy
authors.initials: G
authors.lastname: Sorin
authors.forename: Marie-Isabelle
authors.initials: MI
authors.lastname: Lannou
authors.forename: Jean-Pierre
authors.initials: JP
authors.lastname: Férézou
authors.forename: Janick
authors.initials: J
authors.lastname: Ardisson
mesh_terms: D003500:Cyclization; D015394:Molecular Structure; D013237:Stereoisomerism; D019284:Thapsigargin / Q000138:chemical synthesis* / Q000737:chemistry*
chemical_list: D019284:Thapsigargin