title: Toward efficient asymmetric carbon-carbon bond formation: continuous flow with chiral heterogeneous catalysts.
abstract: A chiral Ca catalyst based on CaCl(2)  with a chiral ligand was developed and applied to the asymmetric 1,4-addition of 1,3-dicarbonyl compounds to nitroalkenes as a model system. To address product inhibition issues, the Ca catalyst was applied to continuous flow with a chiral heterogeneous catalyst. The continuous flow system using a newly synthesized, polymer-supported Pybox was successfully employed, and the TON was improved 25-fold compared with those of the previous Ca(OR)(2)  catalysts.
authors.affiliation: Department of Chemistry, School of Science, The University of Tokyo, Hongo, Bunkyo-ku, Japan.
authors.forename: Tetsu
authors.initials: T
authors.lastname: Tsubogo
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Yamashita
authors.forename: Shū
authors.initials: S
authors.lastname: Kobayashi
mesh_terms: D000475:Alkenes / Q000737:chemistry; D002118:Calcium / Q000737:chemistry; D002244:Carbon / Q000737:chemistry*; D002384:Catalysis; D010080:Oxazoles / Q000737:chemistry; D011108:Polymers / Q000737:chemistry; D011725:Pyridines / Q000737:chemistry; D013237:Stereoisomerism
chemical_list: C530038:(4'S,5'S)-2,6-bis(4'-(triisopropylsilyl)oxymethyl-5'-phenyl-1',3'-oxazolin-2'-yl)pyridine; D000475:Alkenes; D010080:Oxazoles; D011108:Polymers; D011725:Pyridines; D002244:Carbon; D002118:Calcium