title: Quantitative emergence of hetero[4]rotaxanes by template-directed click chemistry.
abstract: In one fell swoop, polyrotaxanes comprising up to 64 rings can be synthesized as a result of cucurbit[6]uril-templated 1,3-dipolar azide-alkyne cycloadditions accelerated in the presence of cyclodextrins as a consequence of self-sorting and positive cooperativity, brought about by hydrogen bonding. Mixing six components in one pot affords a hetero[4]rotaxane in one minute in quantitative yield.
authors.affiliation: Center for the Chemistry of Integrated Systems, Department of Chemistry, Northwestern University, Evanston, IL 60208, USA.
authors.forename: Chenfeng
authors.initials: C
authors.lastname: Ke
authors.forename: Ronald A
authors.initials: RA
authors.lastname: Smaldone
authors.forename: Takashi
authors.initials: T
authors.lastname: Kikuchi
authors.forename: Hao
authors.initials: H
authors.lastname: Li
authors.forename: Anthony P
authors.initials: AP
authors.lastname: Davis
authors.forename: J Fraser
authors.initials: JF
authors.lastname: Stoddart
mesh_terms: D057930:Click Chemistry / Q000379:methods*; D007700:Kinetics; D043862:Rotaxanes / Q000737:chemistry*; D013816:Thermodynamics
chemical_list: D043862:Rotaxanes