title: Normal hematopoiesis and hematologic malignancies: role of canonical Wnt signaling pathway and stromal microenvironment.
abstract: Wnts are a family of evolutionary-conserved secreted signaling molecules critically involved in a variety of developmental processes and in cell fate determination. A growing body of evidence suggests that Wnt signaling plays a crucial role in the influence of bone marrow stromal microenvironment on the balance between hematopoietic stem cell self-renewal and differentiation. Emerging clinical and experimental evidence also indicates Wnt signaling involvement in the disruption of the latter balance in hematologic malignancies, where the stromal microenvironment favors the homing of cancer cells to the bone marrow, as well as leukemia stem cell development and chemoresistance. In the present review, we summarize and discuss the role of the canonical Wnt signaling pathway in normal hematopoiesis and hematologic malignancies, with regard to recent findings on the stromal microenvironment involvement in these process and diseases.
authors.affiliation: Department of Basic Health Sciences, College of Applied Medical Sciences, Qassim University, Buraydah, 51452 Al-Qaseem, Saudi Arabia.
authors.forename: Paul Faustin
authors.initials: PF
authors.lastname: Seke Etet
authors.forename: Lorella
authors.initials: L
authors.lastname: Vecchio
authors.forename: Patrice
authors.initials: P
authors.lastname: Bogne Kamga
authors.forename: Elias
authors.initials: E
authors.lastname: Nchiwan Nukenine
authors.forename: Mauro
authors.initials: M
authors.lastname: Krampera
authors.forename: Armel Hervé
authors.initials: AH
authors.lastname: Nwabo Kamdje
mesh_terms: D000818:Animals; D019337:Hematologic Neoplasms / Q000378:metabolism* / Q000473:pathology*; D006410:Hematopoiesis / Q000502:physiology*; D006801:Humans; D017154:Stromal Cells / Q000378:metabolism / Q000473:pathology; D059016:Tumor Microenvironment / Q000502:physiology*; D051153:Wnt Proteins / Q000378:metabolism*; D060449:Wnt Signaling Pathway
chemical_list: D051153:Wnt Proteins