title: Clonal trisomy 4 cells detected in the ossifying renal tumor of infancy: study of 3 cases.
abstract: The ossifying renal tumor of infancy is a rare neoplasm diagnosed in the first 2 years of life, predominantly in boys. The neoplasm is primarily characterized by the presence of a large ossifying component. Its most common mode of presentation is hematuria, and it has a uniformly benign behavior. The karyotypic makeup of the process has not been reported. Thus, a study was undertaken and it allowed demonstration of clonal trisomy 4, which was confirmed by the fluorescent in-situ hybridization-probing of two additional archival formalin-fixed, paraffin-imbedded similar tumors. On the basis of the findings in these three cases, it seems that clonal trisomy 4 may be considered as a characteristic of the tumor, which makes it distinct from any other infantile renal tumor.
authors.affiliation: Department of Pathology and Laboratory Medicine, Drexel University College of Medicine and St. Christopher's Hospital for Children, Philadelphia, PA, USA.
authors.forename: Jinglan
authors.initials: J
authors.lastname: Liu
authors.forename: Miguel A
authors.initials: MA
authors.lastname: Guzman
authors.forename: Bruce R
authors.initials: BR
authors.lastname: Pawel
authors.forename: Donna M
authors.initials: DM
authors.lastname: Pezanowski
authors.forename: Dilipkumar M
authors.initials: DM
authors.lastname: Patel
authors.forename: Jonathan A
authors.initials: JA
authors.lastname: Roth
authors.forename: Gregory E
authors.initials: GE
authors.lastname: Halligan
authors.forename: Jean-Pierre
authors.initials: JP
authors.lastname: de Chadarévian
mesh_terms: D002894:Chromosomes, Human, Pair 4; D006801:Humans; D007223:Infant; D007680:Kidney Neoplasms / Q000235:genetics / Q000473:pathology*; D008297:Male; D009999:Ossification, Heterotopic / Q000235:genetics / Q000473:pathology*; D014314:Trisomy / Q000235:genetics / Q000473:pathology*