title: Association of three SNPs in interleukin-28B with graft hepatic  dysfunction after liver  transplantation in Chinese Han population.
abstract: BACKGROUND
  Recurrent graft infection limited the effect of LT, early recognition and prophylaxis of HBV recurrence are very important, and interleukin 28B (IL‐28B) gene was reported to be associated with HBV infection.
  
  
  OBJECTIVE
  To explore the association between IL-28B single-nucleotide polymorphisms (SNPs) and graft re-infection after liver transplantation(LT).
  
  
  METHODS
  21 recipients with hepatitis B virus(HBV) recurrence and 157 recipients without HBV recurrence were included. We studied three SNPs in the promoter region of IL-28B gene at the positions rs12979860,rs12980275 and rs8099917 by HRM analysis (high-resolution melting curve analysis).
  
  
  RESULTS
  Hepatic allograft dysfunction was more likely to be associated with IL-28B SNPs. However, there was no significant difference in the frequencies of IL-28B gene distribution in recipients with or without HBV recurrence.
  
  
  CONCLUSIONS
  IL-28B gene polymorphism may be associated with the prognosis of LT recipients but it needs more experiments.
authors.affiliation: Department of Laboratory Medicine, West China Hospital, Sichuan University, Chengdu 610041, PR China.
authors.forename: Jie
authors.initials: J
authors.lastname: Chen
authors.forename: Yi
authors.initials: Y
authors.lastname: Li
authors.forename: Lanlan
authors.initials: L
authors.lastname: Wang
authors.forename: Yang
authors.initials: Y
authors.lastname: Fu
authors.forename: Yun
authors.initials: Y
authors.lastname: Liao
authors.forename: Junlong
authors.initials: J
authors.lastname: Zhang
mesh_terms: D000328:Adult; D044466:Asian People / Q000235:genetics*; D016022:Case-Control Studies; D004247:DNA / Q000235:genetics; D005260:Female; D006084:Graft Rejection / Q000235:genetics*; D006509:Hepatitis B / Q000235:genetics / Q000821:virology; D006515:Hepatitis B virus / Q000472:pathogenicity; D006801:Humans; D007372:Interferons; D007378:Interleukins / Q000235:genetics*; D008107:Liver Diseases / Q000235:genetics* / Q000628:therapy / Q000821:virology; D016031:Liver Transplantation / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged; D016133:Polymerase Chain Reaction; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D012008:Recurrence; D000095022:Interferon Lambda
chemical_list: D004247:DNA; D007372:Interferons; D007378:Interleukins; C000624353:interferon-lambda, human; D000095022:Interferon Lambda