title: Two new alkylresorcinols from Homalomena wendlandii and their cytotoxic activity.
abstract: In the course of our search for antineoplasic agents from Panamanian Flora, two new alkylresorcinols: 1-(2,6-dihydroxyphenyl)octan-l-one (1) and (+)-1-(3-(1-(2,6-dihydroxyphenyl)butyl)-2,6-dihydroxyphenyl)octan-l-one (2), together with three known compounds, (1R, 2R)-l-(benzo[d][1,3]dioxol-5-yl)propane-1,2,3-triol (3), (+)-aptosimon (4) and (-)-sesamin (5), were identified from the leaves of Homalomena wendlandii Schott (Araceae). Their structures were established by 1D and 2D NMR and IR spectroscopic, and MS methods. Compound 2 exhibited IC50 values of 3.3, 5.8 and 4.0 microg/mL against MCF-7, SF-268 and H-460 cancer human cell lines, respectively.
authors.affiliation: Center for Pharmacognostic Research on Panamanian Flora (CIFLORPAN), College of Pharmacy, University of Panama, Calle Manuel Espinosa Batista, 0824-00172, Estafeta Universitaria, Panamá, República de Panamá.
authors.forename: Luis A
authors.initials: LA
authors.lastname: Sánchez
authors.forename: Dionisio
authors.initials: D
authors.lastname: Olmedo
authors.forename: José Luis
authors.initials: JL
authors.lastname: López-Pérez
authors.forename: Todd D
authors.initials: TD
authors.lastname: Williams
authors.forename: Mahabir P
authors.initials: MP
authors.lastname: Gupta
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000494:pharmacology*; D029064:Araceae / Q000737:chemistry*; D015394:Molecular Structure; D012118:Resorcinols / Q000737:chemistry*
chemical_list: C575460:1-(2,6-dihydroxyphenyl)octan-l-one; C575461:1-(3-(1-(2,6-dihydroxyphenyl)butyl)-2,6-dihydroxyphenyl)octan-l-one; D000972:Antineoplastic Agents, Phytogenic; D012118:Resorcinols