title: A case of transient central diabetes insipidus after aorto-coronary bypass operation.
abstract: Diabetes insipidus (DI) is characterized by excessive urination and thirst. This disease results from inadequate output of antidiuretic hormone (ADH) from the pituitary gland or the absence of the normal response to ADH in the kidney. We present a case of transient central DI in a patient who underwent a cardiopulmonary bypass (CPB) for coronary artery bypass grafting (CABG). A 44-yr-old male underwent a CABG operation. An hour after the operation, the patient developed polyuria and was diagnosed with central DI. The patient responded to desmopressin and completely recovered five days after surgery. It is probable that transient cerebral ischemia resulted in the dysfunction of osmotic receptors in the hypothalamus or hypothalamus-pituitary axis during CPB. It is also possible that cardiac standstill altered the left atrial non-osmotic receptor function and suppressed ADH release. Therefore, we suggest that central DI is a possible cause of polyuria after CPB.
authors.affiliation: Department of Internal Medicine, Kyungpook National University Hospital, Daegu, Korea.
authors.forename: Chung-Hoon
authors.initials: CH
authors.lastname: Yu
authors.forename: Jang-Hee
authors.initials: JH
authors.lastname: Cho
authors.forename: Hee-Yeon
authors.initials: HY
authors.lastname: Jung
authors.forename: Jeong-Hoon
authors.initials: JH
authors.lastname: Lim
authors.forename: Mi-Kyung
authors.initials: MK
authors.lastname: Jin
authors.forename: Owen
authors.initials: O
authors.lastname: Kwon
authors.forename: Kyung-Deuk
authors.initials: KD
authors.lastname: Hong
authors.forename: Ji-Young
authors.initials: JY
authors.lastname: Choi
authors.forename: Se-Hee
authors.initials: SH
authors.lastname: Yoon
authors.forename: Chan-Duck
authors.initials: CD
authors.lastname: Kim
authors.forename: Yong-Lim
authors.initials: YL
authors.lastname: Kim
authors.forename: Gun-Jik
authors.initials: GJ
authors.lastname: Kim
authors.forename: Sun-Hee
authors.initials: SH
authors.lastname: Park
mesh_terms: D000328:Adult; D050034:Antidiuretic Agents / Q000627:therapeutic use; D001026:Coronary Artery Bypass / Q000009:adverse effects*; D003331:Coronary Vessels; D003894:Deamino Arginine Vasopressin / Q000627:therapeutic use; D020790:Diabetes Insipidus, Neurogenic / Q000175:diagnosis* / Q000188:drug therapy / Q000209:etiology; D006801:Humans; D007031:Hypothalamus / Q000000981:diagnostic imaging; D008279:Magnetic Resonance Imaging; D008297:Male; D010902:Pituitary Gland / Q000000981:diagnostic imaging; D011141:Polyuria / Q000175:diagnosis / Q000209:etiology; D011183:Postoperative Complications / Q000175:diagnosis* / Q000188:drug therapy / Q000209:etiology; D011877:Radionuclide Imaging
chemical_list: D050034:Antidiuretic Agents; D003894:Deamino Arginine Vasopressin