title: A nanomaterial-based breath test for short-term follow-up after lung tumor resection.
abstract: In this case study, we demonstrate the feasibility of nanomaterial-based sensors for identifying the breath-print of early-stage lung cancer (LC) and for short-term follow-up after LC-resection. Breath samples were collected from a small patient cohort prior to and after lung resection. Gas-chromatography/mass-spectrometry showed that five volatile organic compounds were significantly reduced after LC surgery. A nanomaterial-based sensor-array distinguished between pre-surgery and post-surgery LC states, as well as between pre-surgery LC and benign states. In contrast, the same sensor-array could neither distinguish between pre-surgery and post-surgery benign states, nor between LC and benign states after surgery. This indicates that the observed pattern is associated with the presence of malignant lung tumors. The proof-of-concept presented here has initiated a large-scale clinical study for post-surgery follow-up of LC patients.
  
  
  BACKGROUND
  Monitoring for tumor recurrence remains very challenging due to post-surgical and radiation therapy induced changes in target organs, which often renders standard radiological identification of recurrent malignancies inaccurate. In this paper a novel nanotechnology-based sensor array is used for identification of volatile organic compounds in exhaled air that enable identification of benign vs. malignant states.
authors.affiliation: Department of Chemical Engineering and Russell Berrie Nanotechnology Institute, Technion-Israel Institute of Technology, Haifa, Israel.
authors.forename: Yoav Y
authors.initials: YY
authors.lastname: Broza
authors.forename: Ran
authors.initials: R
authors.lastname: Kremer
authors.forename: Ulrike
authors.initials: U
authors.lastname: Tisch
authors.forename: Arsen
authors.initials: A
authors.lastname: Gevorkyan
authors.forename: Ala
authors.initials: A
authors.lastname: Shiban
authors.forename: Lael Anson
authors.initials: LA
authors.lastname: Best
authors.forename: Hossam
authors.initials: H
authors.lastname: Haick
mesh_terms: D001944:Breath Tests; D015331:Cohort Studies; D008401:Gas Chromatography-Mass Spectrometry; D006801:Humans; D008175:Lung Neoplasms / Q000503:physiopathology / Q000601:surgery*; D036103:Nanotechnology; D055549:Volatile Organic Compounds / Q000032:analysis
chemical_list: D055549:Volatile Organic Compounds