title: 1,5-Anhydro-D-fructose: A natural antibiotic that inhibits the growth of gram-positive bacteria and microbial biofilm formation to prevent nosocomial infection.
abstract: Nosocomial infections caused by microbial opportunistic infections or microbial biofilms may occur during hospitalization and increase patient morbidity, mortality and health care costs. Artificial antibiotic agents were initially used to prevent infection; however, the high prevalence of nosocomial infections has resulted in their excessive use, which has led to microbial resistance to these agents. The increase in microbial resistance to antibiotics and the development of antibiotic agents may be the cause of the production of other microbial resistance. Thus, natural compounds that have no adverse side effects would be a preferred treatment modality. Recently, the monosaccharide 1,5-anhydro-D-fructose (1,5-AF), a natural plant compound derived from starch, has been found to have multifunctional properties, including antioxidant, antiplatelet aggregation by thrombin and anti-inflammatory activities. The results of the present study demonstrate that 1,5-AF suppressed the growth of coagulase-negative staphylococci on the hands as well as the growth of Staphylococcus epidermidis, which is a cause of opportunistic infections. Furthermore, 1,5-AF suppressed biofilm formation by the methicillin-resistant Staphylococcus aureus. In conclusion, 1,5-AF is a natural compound that may be effective in preventing nosocomial infections, without causing adverse side effects.
authors.affiliation: Department of Laboratory and Vascular Medicine, Cardiovascular and Respiratory Disorders, Advanced Therapeutics;
authors.forename: Xiaojie
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authors.lastname: Meng
authors.forename: Ko-Ichi
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authors.lastname: Kawahara
authors.forename: Hiroaki
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authors.lastname: Miyanohara
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authors.lastname: Yoshimoto
authors.forename: Kazuhiro
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authors.forename: Satoshi
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authors.lastname: Noma
authors.forename: Kiyoshi
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authors.forename: Binita
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authors.lastname: Shrestha
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authors.lastname: Chandan
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authors.forename: Ko-Ichi
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authors.lastname: Tada
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authors.lastname: Miura
authors.forename: Yoshiko
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authors.lastname: Ono
authors.forename: Kazunori
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authors.lastname: Takenouchi
authors.forename: Ryuichi
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authors.lastname: Maenosono
authors.forename: Tomoka
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authors.lastname: Nagasato
authors.forename: Teruto
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authors.lastname: Hashiguchi
authors.forename: Ikuro
authors.initials: I
authors.lastname: Maruyama