title: Brevianamides with antitubercular potential from a marine-derived isolate of Aspergillus versicolor.
abstract: An Aspergillus versicolor isolated from sediment collected from the Bohai Sea, China, yielded the new dimeric diketopiperazine brevianamide S (1), together with three new monomeric cometabolites, brevianamides T (2), U (3), and V (4). Structures were determined by detailed spectroscopic analysis. Brevianamide S exhibited selective antibacterial activity against Bacille Calmette-Guérin (BCG), suggestive of a new mechanism of action that could inform the development of next-generation antitubercular drugs.
authors.affiliation: Chinese Academy of Sciences Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100190, China.
authors.forename: Fuhang
authors.initials: F
authors.lastname: Song
authors.forename: Xinru
authors.initials: X
authors.lastname: Liu
authors.forename: Hui
authors.initials: H
authors.lastname: Guo
authors.forename: Biao
authors.initials: B
authors.lastname: Ren
authors.forename: Caixia
authors.initials: C
authors.lastname: Chen
authors.forename: Andrew M
authors.initials: AM
authors.lastname: Piggott
authors.forename: Ke
authors.initials: K
authors.lastname: Yu
authors.forename: Hong
authors.initials: H
authors.lastname: Gao
authors.forename: Qian
authors.initials: Q
authors.lastname: Wang
authors.forename: Mei
authors.initials: M
authors.lastname: Liu
authors.forename: Xueting
authors.initials: X
authors.lastname: Liu
authors.forename: Huanqin
authors.initials: H
authors.lastname: Dai
authors.forename: Lixin
authors.initials: L
authors.lastname: Zhang
authors.forename: Robert J
authors.initials: RJ
authors.lastname: Capon
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D000995:Antitubercular Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D001230:Aspergillus / Q000737:chemistry*; D002681:China; D054659:Diketopiperazines / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D009163:Mycobacterium bovis / Q000187:drug effects*; D019906:Nuclear Magnetic Resonance, Biomolecular; D009792:Oceans and Seas
chemical_list: D000900:Anti-Bacterial Agents; D000995:Antitubercular Agents; D054659:Diketopiperazines