title: Parametric mapping of brain tissues from diffusion kurtosis tensor.
abstract: Diffusion kurtosis imaging (DKI) is a new diffusion magnetic resonance imaging (MRI) technique to go beyond the shortages of conventional diffusion tensor imaging (DTI) from the assumption that water diffuse in biological tissue is Gaussian. Kurtosis is used to measure the deviation of water diffusion from Gaussian model, which is called non-Gaussian, in DKI. However, the high-order kurtosis tensor in the model brings great difficulties in feature extraction. In this study, parameters like fractional anisotropy of kurtosis eigenvalues (FAek) and mean values of kurtosis eigenvalues (Mek) were proposed, and regional analysis was performed for 4 different tissues: corpus callosum, crossing fibers, thalamus, and cerebral cortex, compared with other parameters. Scatterplot analysis and Gaussian mixture decomposition of different parametric maps are used for tissues identification. Diffusion kurtosis information extracted from kurtosis tensor presented a more detailed classification of tissues actually as well as clinical significance, and the FAek of D-eigenvalues showed good sensitivity of tissues complexity which is important for further study of DKI.
authors.affiliation: Department of Biomedical Engineering, Tianjin University, Tianjin 300072, China.
authors.forename: Yuanyuan
authors.initials: Y
authors.lastname: Chen
authors.forename: Xin
authors.initials: X
authors.lastname: Zhao
authors.forename: Hongyan
authors.initials: H
authors.lastname: Ni
authors.forename: Jie
authors.initials: J
authors.lastname: Feng
authors.forename: Hao
authors.initials: H
authors.lastname: Ding
authors.forename: Hongzhi
authors.initials: H
authors.lastname: Qi
authors.forename: Baikun
authors.initials: B
authors.lastname: Wan
authors.forename: Dong
authors.initials: D
authors.lastname: Ming
mesh_terms: D000328:Adult; D016880:Anisotropy; D001921:Brain / Q000473:pathology; D001931:Brain Mapping / Q000379:methods; D002540:Cerebral Cortex / Q000473:pathology; D004058:Diffusion; D056324:Diffusion Tensor Imaging / Q000379:methods; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods; D008279:Magnetic Resonance Imaging / Q000379:methods*; D056004:Molecular Dynamics Simulation; D016011:Normal Distribution; D014867:Water / Q000737:chemistry
chemical_list: D014867:Water