title: Increased percentage of CD8+CD28- T cells correlates with clinical activity in primary Sjögren's syndrome.
abstract: The role of CD28- T cell subpopulations in primary Sjögren's syndrome (pSS) has become controversial. Changes in the number of CD28- T cells have been demonstrated in autoimmune diseases in co-existence with Sjögren's syndrome. The study aimed to indicate differences in the number of CD4+CD28- and CD8+CD28- T cells in patients with sicca syndrome and suspected pSS. Thirty patients with sicca syndrome at baseline were studied and followed up for 5 months. After final diagnosis, comparison was made of the previously recorded lymphocyte subpopulations in patients with pSS and those in other defined subgroups. Notably high percentages of CD8+CD28- T cells were indicated in pSS patients, which correlated with the severity of the sicca symptoms and cutaneous and muscular systemic disease activity. Changes in CD8+CD28- T cell percentages may thus assist in the early differential diagnosis of pSS patients from those with similar clinical symptoms.
authors.affiliation: Department of Internal Medicine, Connective Tissue Diseases and Geriatrics, Medical University of Gdańsk, Poland.
authors.forename: Zaneta
authors.initials: Z
authors.lastname: Smoleńska
authors.forename: Justyna
authors.initials: J
authors.lastname: Pawłowska
authors.forename: Zbigniew
authors.initials: Z
authors.lastname: Zdrojewski
authors.forename: Agnieszka
authors.initials: A
authors.lastname: Daca
authors.forename: Ewa
authors.initials: E
authors.lastname: Bryl
mesh_terms: D000328:Adult; D000368:Aged; D018106:CD28 Antigens / Q000276:immunology; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology / Q000473:pathology*; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology / Q000473:pathology*; D005260:Female; D005434:Flow Cytometry; D006801:Humans; D018655:Lymphocyte Count; D008297:Male; D008875:Middle Aged; D012720:Severity of Illness Index; D012859:Sjogren's Syndrome / Q000276:immunology / Q000473:pathology*
chemical_list: D018106:CD28 Antigens