title: Lichen sclerosus and immunobullous disease.
abstract: We report 3 patients with long-standing lichen sclerosus who subsequently developed new onset erosive disease in affected sites. Repeated biopsies were performed which, although not diagnostic, showed some features of bullous pemphigoid for 1 patient and nonspecific findings for the 2 others. Direct immunofluorescence showed the characteristic findings of bullous pemphigoid in the first and pemphigus vulgaris in the others. All 3 patients were treated with immunosuppressive agents, and their condition improved dramatically.
authors.affiliation: Department of Dermatology, Broadgreen Hospital, Liverpool, United Kingdom. maeve.walsh@rlbuht.nhs.uk
authors.forename: Maeve L
authors.initials: ML
authors.lastname: Walsh
authors.forename: Niamh
authors.initials: N
authors.lastname: Leonard
authors.forename: Howida
authors.initials: H
authors.lastname: Shawki
authors.forename: Hazel K
authors.initials: HK
authors.lastname: Bell
mesh_terms: D000368:Aged; D001706:Biopsy; D005260:Female; D006651:Histocytochemistry; D006801:Humans; D007150:Immunohistochemistry; D018459:Lichen Sclerosus et Atrophicus / Q000175:diagnosis* / Q000473:pathology*; D008853:Microscopy; D008875:Middle Aged; D010391:Pemphigoid, Bullous / Q000473:pathology; D010392:Pemphigus / Q000473:pathology; D014845:Vulvar Diseases / Q000175:diagnosis* / Q000473:pathology*