title: Effects of intrahippocampal L-NAME treatment on the behavioral long-term potentiation in dentate gyrus.
abstract: Using a combination of electrophysiological recordings, behavioral tests and local pharmacological administration in hippocampus, we investigated in the present study the effects of nitric oxide (NO) synthase inhibitor N-nitro-l-arginine methyl ester (l-NAME) on the behavioral long-term potentiation (LTP) and maze learning performance in freely moving rats. The results showed as follows: (1) intrahippocampal l-NAME administration led to a defect in maze learning performance of the animals; (2) l-NAME treatment also substantially impaired the induction of the behavioral LTP in perforant pathway to dentate gyrus (PP-DG) pathway induced by maze learning task, while it had no significant effects on basic synaptic transmission in PP-DG pathway; Collectively, these results indicate that NO synthesis may be critical for the behavioral LTP in PP-DG pathway and maze learning performance.
authors.affiliation: College of Life Science, South China Normal University, Guangzhou 510631, China.
authors.forename: Chu-Hua
authors.initials: CH
authors.lastname: Li
authors.forename: Shu-Zhen
authors.initials: SZ
authors.lastname: Wang
authors.forename: Zhao-Lin
authors.initials: ZL
authors.lastname: Cai
authors.forename: Wen-Xiao
authors.initials: WX
authors.lastname: Liu
authors.forename: Shi-Tong
authors.initials: ST
authors.lastname: Xu
authors.forename: Peng
authors.initials: P
authors.lastname: Xiao
mesh_terms: D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects*; D018891:Dentate Gyrus / Q000187:drug effects* / Q000502:physiology; D006624:Hippocampus / Q000187:drug effects* / Q000502:physiology; D017774:Long-Term Potentiation / Q000187:drug effects*; D008297:Male; D018782:Maze Learning / Q000187:drug effects; D008568:Memory / Q000187:drug effects; D019331:NG-Nitroarginine Methyl Ester / Q000494:pharmacology*; D019001:Nitric Oxide Synthase / Q000037:antagonists & inhibitors*; D019580:Perforant Pathway / Q000187:drug effects / Q000502:physiology; D051381:Rats; D017207:Rats, Sprague-Dawley; D009435:Synaptic Transmission / Q000187:drug effects
chemical_list: D019001:Nitric Oxide Synthase; D019331:NG-Nitroarginine Methyl Ester