title: A snapshot of histone modifications within transposable elements in Drosophila wild type strains.
abstract: Transposable elements (TEs) are a major source of genetic variability in genomes, creating genetic novelty and driving genome evolution. Analysis of sequenced genomes has revealed considerable diversity in TE families, copy number, and localization between different, closely related species. For instance, although the twin species Drosophila melanogaster and D. simulans share the same TE families, they display different amounts of TEs. Furthermore, previous analyses of wild type derived strains of D. simulans have revealed high polymorphism regarding TE copy number within this species. Several factors may influence the diversity and abundance of TEs in a genome, including molecular mechanisms such as epigenetic factors, which could be a source of variation in TE success. In this paper, we present the first analysis of the epigenetic status of four TE families (roo, tirant, 412 and F) in seven wild type strains of D. melanogaster and D. simulans. Our data shows intra- and inter-specific variations in the histone marks that adorn TE copies. Our results demonstrate that the chromatin state of common TEs varies among TE families, between closely related species and also between wild type strains.
authors.affiliation: Laboratoire de Biométrie et Biologie Evolutive, UMR5558, CNRS, Université de Lyon, Université Lyon 1, Villeurbanne, France.
authors.forename: Rita
authors.initials: R
authors.lastname: Rebollo
authors.forename: Béatrice
authors.initials: B
authors.lastname: Horard
authors.forename: Flora
authors.initials: F
authors.lastname: Begeot
authors.forename: Marion
authors.initials: M
authors.lastname: Delattre
authors.forename: Eric
authors.initials: E
authors.lastname: Gilson
authors.forename: Cristina
authors.initials: C
authors.lastname: Vieira
mesh_terms: D000818:Animals; D005075:Biological Evolution; D002843:Chromatin / Q000378:metabolism; D056915:DNA Copy Number Variations; D019175:DNA Methylation; D004251:DNA Transposable Elements; D004330:Drosophila / Q000235:genetics* / Q000378:metabolism; D004331:Drosophila melanogaster / Q000235:genetics / Q000378:metabolism; D044127:Epigenesis, Genetic; D015870:Gene Expression; D014644:Genetic Variation; D049750:Genome, Insect; D005838:Genotype; D006657:Histones / Q000235:genetics* / Q000378:metabolism; D011499:Protein Processing, Post-Translational; D013045:Species Specificity
chemical_list: D002843:Chromatin; D004251:DNA Transposable Elements; D006657:Histones