title: Salivary bisphenol-A levels due to dental sealant/resin: a case-control study in Korean children.
abstract: Dental sealants and composite filling materials containing bisphenol-A (BPA) derivatives are increasingly used in children. The aim of this study was to evaluate the association between salivary BPA and the number of tooth surfaces filled with dental sealant, and to determine a cutoff BPA level. Salivary BPA concentration and the number of tooth surfaces filled with dental sealant/resin were determined in 124 age and gender matched children: 62 controls had no dental sealant/resin on their tooth surfaces and 62 cases had more than 4 tooth surfaces with dental sealant/resin. Analysis of covariance (ANCOVA) and conditional logistic regression were performed after controlling for age, gender, salivary flow rate, salivary buffer capacity, frequency of snacking, and frequency of tooth brushing. Salivary BPA levels were 0.002 to 8.305 µg/L. The BPA level of control (0.40 µg/L) was significantly lower than that of case (0.92 µg/L) after controlling for confounders (P = 0.026). Although the 90th BPA percentile had an adjusted OR of 4.58 (95% CI 1.04-20.26, P = 0.045), the significance disappeared in the conditional logistic model. There may be a relationship between salivary BPA level and dental sealant/resin.
authors.affiliation: Department of Preventive and Social Dentistry, School of Dentistry, Seoul National University, Seoul, Korea. dhhan73@snu.ac.kr
authors.forename: Dong-Hun
authors.initials: DH
authors.lastname: Han
authors.forename: Min-Ji
authors.initials: MJ
authors.lastname: Kim
authors.forename: Eun-Joo
authors.initials: EJ
authors.lastname: Jun
authors.forename: Jin-Bom
authors.initials: JB
authors.lastname: Kim
mesh_terms: D000293:Adolescent; D000704:Analysis of Variance; D044466:Asian People; D001559:Benzhydryl Compounds / Q000032:analysis*; D016022:Case-Control Studies; D002648:Child; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D016015:Logistic Models; D008297:Male; D016017:Odds Ratio; D010636:Phenols / Q000032:analysis*; D010895:Pit and Fissure Sealants / Q000737:chemistry*; D056910:Republic of Korea; D012117:Resins, Synthetic / Q000737:chemistry*; D012463:Saliva / Q000737:chemistry*; D062410:Snacks; D000098826:Bisphenol A Compounds
chemical_list: D001559:Benzhydryl Compounds; D010636:Phenols; D010895:Pit and Fissure Sealants; D012117:Resins, Synthetic; C006780:bisphenol A; D000098826:Bisphenol A Compounds