title: CT imaging and histopathological features of renal epithelioid angiomyolipomas.
abstract: OBJECTIVE
  To describe computed tomography (CT) imaging and histopathological manifestations of renal epithelioid angiomyolipomas (EAMLs) for better understanding and cognition in the diagnosis of this new category of renal tumours.
  
  
  METHODS
  Clinical data and CT images from 10 cases of EAML were retrospectively analysed. All patients underwent CT with and without contrast medium administration, with multiplanar reconstruction (MPR) when needed.
  
  
  RESULTS
  Plain CT manifestations of EAMLs were a higher density of mass (10-25 HU) than renal parenchyma, bulging contour of the involved kidney, absence of fat, distinct edges without a lobulate appearance. Contrast-enhanced CT features were markedly heterogeneous enhancement (from rapid wash-in to slow wash-out), large tumour size without lobular appearance, complete capsule with distinct margins and frequent mild necrotic areas. Histopathological features were epithelioid cells with eosinophilic cytoplasm, large and deeply stained nuclei, and dense arrangement of tumour cells with patchy necrosis; diffuse sheets of epithelioid cells were positive for HMB-45 (melanoma-associated antigen) and negative for epithelial membrane antigen (EMA) staining.
  
  
  CONCLUSIONS
  Multiple specific CT features correlated well with the histopathology and may play an important role in the primary diagnosis of EAMLs.
authors.affiliation: Department of Radiology, The Second Affiliated Hospital of Nantong University, Jiangsu Province, People's Republic of China.
authors.forename: L
authors.initials: L
authors.lastname: Cui
authors.forename: J-G
authors.initials: JG
authors.lastname: Zhang
authors.forename: X-Y
authors.initials: XY
authors.lastname: Hu
authors.forename: X-M
authors.initials: XM
authors.lastname: Fang
authors.forename: A
authors.initials: A
authors.lastname: Lerner
authors.forename: X-J
authors.initials: XJ
authors.lastname: Yao
authors.forename: Z-M
authors.initials: ZM
authors.lastname: Zhu
mesh_terms: D000328:Adult; D018207:Angiomyolipoma / Q000000981:diagnostic imaging* / Q000473:pathology; D003287:Contrast Media; D003937:Diagnosis, Differential; D015622:Epithelioid Cells / Q000000981:diagnostic imaging* / Q000473:pathology; D005260:Female; D006801:Humans; D007680:Kidney Neoplasms / Q000000981:diagnostic imaging* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D011857:Radiographic Image Interpretation, Computer-Assisted; D012189:Retrospective Studies; D014057:Tomography, X-Ray Computed / Q000379:methods*
chemical_list: D003287:Contrast Media