title: Ceftiaxone-induced neurotoxicity: case report, pharmacokinetic considerations, and literature review.
abstract: Ceftriaxone is widely used in patients for the treatment of serious gram-negative infections. Ceftriaxone can induce some potential side effects, including neurotoxicity, however, nonconvulsive status epilepticus has rarely been reported. We report a case of acute reversible neurotoxicity associated with ceftriaxone. A 65-yr-old woman with chronic kidney disease developed altered consciousness during ceftriaxone treatment for urinary tract infection. The electroencephalogram demonstrated continuous bursts of generalized, high-voltage, 1 to 2 Hz sharp wave activity. Neurologic symptoms disappeared following withdrawal of ceftriaxone. The possibility of ceftriaxone-induced neurotoxicity should be considered in patients developing neurological impairment during ceftriaxone use, and the discontinuation of the drug could lead to complete neurological improvement.
authors.affiliation: Department of Internal Medicine, Chungbuk National University Hospital, Cheongju, Korea.
authors.forename: Ki Bae
authors.initials: KB
authors.lastname: Kim
authors.forename: Sun Moon
authors.initials: SM
authors.lastname: Kim
authors.forename: Woori
authors.initials: W
authors.lastname: Park
authors.forename: Ji Seon
authors.initials: JS
authors.lastname: Kim
authors.forename: Soon Kil
authors.initials: SK
authors.lastname: Kwon
authors.forename: Hye-Young
authors.initials: HY
authors.lastname: Kim
mesh_terms: D000368:Aged; D000900:Anti-Bacterial Agents / Q000009:adverse effects* / Q000627:therapeutic use; D000925:Anticoagulants / Q000627:therapeutic use; D002443:Ceftriaxone / Q000009:adverse effects* / Q000627:therapeutic use; D004569:Electroencephalography; D005260:Female; D006801:Humans; D009422:Nervous System Diseases / Q000209:etiology*; D006435:Renal Dialysis; D051436:Renal Insufficiency, Chronic / Q000473:pathology; D012640:Seizures / Q000209:etiology; D013927:Thrombosis / Q000175:diagnosis / Q000188:drug therapy; D014057:Tomography, X-Ray Computed; D016482:Urinalysis; D014552:Urinary Tract Infections / Q000175:diagnosis / Q000188:drug therapy
chemical_list: D000900:Anti-Bacterial Agents; D000925:Anticoagulants; D002443:Ceftriaxone