title: Incidence and outcomes of surgical resection for giant pulmonary bullae--a population-based study.
abstract: BACKGROUND
  Giant pulmonary bullae (GPB) are rare and there is little information on incidence, long-term prognosis, and outcome of treatment.
  
  
  OBJECTIVE
  To assess the incidence of GPB in the Icelandic population and to evaluate the outcome of surgical treatment.
  
  
  METHODS
  Twelve consecutive patients (11 males; mean age 60 ± 15.7 years) underwent resection for GPB in Iceland between 1992 and 2009. All were heavy smokers and had bullae occupying > 30% of the involved lung. There were 8 bilateral and 3 unilateral bullectomies and one lobectomy. Pulmonary function tests were performed preoperatively, and at one month and 5.4 years postoperatively. Age-standardized incidence rate (ASR) was calculated, complications and operative mortality were registered, and overall survival was estimated. Mean follow-up time was 8.2 years.
  
  
  RESULTS
  The ASR for GPB was 0.40 and 0.03 per 100,000 per year for men and women, respectively. There was no operative mortality, but prolonged air leakage (75%) and pneumonia (17%) were the most common postoperative complications. One month postoperatively, mean FEV1 increased from 1.0 ± 0.48 L (33% predicted) to 1.75 ± 0.75 L (57.5% predicted) (p < 0.01), but FVC remained unchanged. RV decreased from 3.9 ± 0.8 L (177% predicted) to 3.0 ± 1.0 L (128% predicted) (p < 0.05), but TLC and DLCO did not change after operation. At long-term follow-up the FEV1 and FVC had declined to near-baseline values. Five-year and 10-year survival were 100% and 60%, respectively.
  
  
  CONCLUSIONS
  The ASR of GPB in Iceland was 0.21 per 100,000 per year. In this small series, bullectomy was found to be a safe procedure that significantly improved pulmonary function. The functional improvement then declined over time. Prolonged air leakage was a common postoperative complication that prolonged hospital stay.
authors.affiliation: Department of Cardiothoracic Surgery, Landspitali University Hospital, Reykjavik, Iceland.
authors.forename: S I
authors.initials: SI
authors.lastname: Gunnarsson
authors.forename: K B
authors.initials: KB
authors.lastname: Johannesson
authors.forename: M
authors.initials: M
authors.lastname: Gudjonsdottir
authors.forename: B
authors.initials: B
authors.lastname: Magnusson
authors.forename: S
authors.initials: S
authors.lastname: Jonsson
authors.forename: T
authors.initials: T
authors.lastname: Gudbjartsson
mesh_terms: D000328:Adult; D000368:Aged; D001768:Blister / Q000453:epidemiology* / Q000209:etiology / Q000401:mortality / Q000601:surgery*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007055:Iceland / Q000453:epidemiology; D015994:Incidence; D053208:Kaplan-Meier Estimate; D008171:Lung Diseases / Q000453:epidemiology* / Q000209:etiology / Q000401:mortality / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D011013:Pneumonectomy; D011183:Postoperative Complications / Q000453:epidemiology; D011656:Pulmonary Emphysema / Q000150:complications; D012042:Registries; D012129:Respiratory Function Tests; D012189:Retrospective Studies; D012907:Smoking / Q000009:adverse effects; D015996:Survival Rate; D016896:Treatment Outcome