title: The influence of drug use in university hospitals on the pharmaceutical consumption in their surrounding communities.
abstract: OBJECTIVE
  To investigate the influence of hospital drug choices on pharmaceutical consumption for nine competitive classes in the surrounding community.
  
  
  METHODS
  Ecological study. Data from the national survey on drugs in hospitals were used to extract quantities purchased by 25 French university hospitals for three 'hospital classes' (EPOs, LMWHs and setrons) and six 'ambulatory classes' (PPIs, ACEIs and ARBs, statins, α-adrenoreceptor antagonists (AAAs) and selective serotonin re-uptake inhibitors SSRIs). Re-imbursed quantities for patients living in the hospital's catchment area were extracted from the national health insurance database. The relationship between the use of a brand in hospitals and their catchment areas was assessed using multivariate linear regressions with instrumental variables.
  
  
  RESULTS
  An increase of 1 day of treatment with one brand in the hospital was associated with a significant increase of 2.8 days of treatment with the same brand in the catchment area. However, results strongly varied according to classes. An increase of 1 day of treatment in the hospital was significantly associated with an increase of 0.21 day for 'hospital classes' and 21.8 days for 'ambulatory classes' in the catchment area. Strong variations were seen across 'ambulatory classes'. The effect was maximal for cardiovascular classes and not significant for AAAs and SSRIs. The size of the effect also varied with hospital characteristics: small and proximity university hospitals exerted the greatest influence.
  
  
  CONCLUSIONS
  Hospital consumption influences the use of drugs in the community. A significant effect was found, especially for competitive classes used on a long-term basis. The economic consequences of these findings need to be addressed.
authors.affiliation: Epidémiologie et analyses en santé publique, INSERM, UMR 1027, Toulouse, France. adeline.gallini@cict.fr
authors.forename: Adeline
authors.initials: A
authors.lastname: Gallini
authors.forename: Renaud
authors.initials: R
authors.lastname: Legal
authors.forename: Florence
authors.initials: F
authors.lastname: Taboulet
mesh_terms: D000553:Ambulatory Care / Q000191:economics*; D002391:Catchment Area, Health / Q000191:economics*; D016527:Drug Costs; D004363:Drug Utilization / Q000191:economics*; D005602:France; D019538:Health Care Surveys; D006785:Hospitals, University / Q000191:economics*; D006801:Humans; D010818:Practice Patterns, Physicians' / Q000191:economics*