title: Neuroprotective effects of Schisandrin B against transient focal cerebral ischemia in Sprague-Dawley rats.
abstract: Fruits of Schisandra have been traditionally used in East Asia for the treatment of dyspnea, cough, dysentery, insomnia, tonic-clonic seizures, and amnesia. Schisandrin B, a dibenzocyclooctadiene derivative isolated from Fructus Schisandrae, has been shown to produce antioxidant effect on rodent liver and heart. In the present study, we investigated the neuroprotective effects of Schisandrin B, a constituent drug of the fruit of Schisandra, against focal cerebral ischemia in rats. Schisandrin B (10, 30 mg/kg, i.p.) was twice administered 30 min before the onset of ischemia and 2h after reperfusion. Schisandrin B 10 and 30 mg/kg treated groups showed infarct volumes reduced by 25.7% and 53.4%, respectively, 2h after occlusion. Also, Schisandrin B treated animal treatment abrogated protein expression of TNF-α and IL-1β and degradation of MMP-2 and MMP-9 in ischemic hemispheres. These results suggest that Schisandrin B treatment provides a neuroprotective effect to rats after transient focal cerebral ischemia by inhibiting inflammation and by protecting against metalloproteinase degradation.
authors.affiliation: Department of Obstetrics and Gynecology, College of Medicine, Kosin University, Republic of Korea.
authors.forename: Tae Hwa
authors.initials: TH
authors.lastname: Lee
authors.forename: Chang Hwa
authors.initials: CH
authors.lastname: Jung
authors.forename: Dae-Hee
authors.initials: DH
authors.lastname: Lee
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000494:pharmacology; D002544:Cerebral Infarction / Q000188:drug therapy; D034242:Cyclooctanes / Q000494:pharmacology; D004365:Drugs, Chinese Herbal / Q000494:pharmacology; D007249:Inflammation / Q000188:drug therapy; D053583:Interleukin-1beta / Q000235:genetics / Q000378:metabolism; D002546:Ischemic Attack, Transient / Q000188:drug therapy*; D017705:Lignans / Q000494:pharmacology*; D008297:Male; D020778:Matrix Metalloproteinase 2 / Q000235:genetics / Q000378:metabolism; D020780:Matrix Metalloproteinase 9 / Q000235:genetics / Q000378:metabolism; D018696:Neuroprotective Agents / Q000494:pharmacology*; D010936:Plant Extracts / Q000494:pharmacology; D011083:Polycyclic Compounds / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D015424:Reperfusion / Q000379:methods; D032141:Schisandra / Q000737:chemistry; D014409:Tumor Necrosis Factor-alpha / Q000235:genetics / Q000378:metabolism
chemical_list: D000975:Antioxidants; D034242:Cyclooctanes; D004365:Drugs, Chinese Herbal; D053583:Interleukin-1beta; D017705:Lignans; D018696:Neuroprotective Agents; D010936:Plant Extracts; D011083:Polycyclic Compounds; D014409:Tumor Necrosis Factor-alpha; C015499:schizandrin B; D020778:Matrix Metalloproteinase 2; C522363:Mmp2 protein, rat; D020780:Matrix Metalloproteinase 9; C572337:Mmp9 protein, rat