title: Protein adsorption on nano-scaled, rippled TiO2 and Si surfaces.
abstract: We synthesized nano-scaled periodic ripple patterns on silicon and titanium dioxide (TiO(2)) surfaces by xenon ion irradiation, and performed adsorption experiments with human plasma fibrinogen (HPF) on such surfaces as a function of the ripple wavelength. Atomic force microscopy showed the adsorption of HPF in mostly globular conformation on crystalline and amorphous flat Si surfaces as well as on nano-structured Si with long ripple wavelengths. For short ripple wavelengths the proteins seem to adsorb in a stretched formation and align across or along the ripples. In contrast to that, the proteins adsorb in a globular assembly on flat and long-wavelength rippled TiO(2), but no adsorbed proteins could be observed on TiO(2) with short ripple wavelengths due to a decrease of the adsorption energy caused by surface curvature. Consequently, the adsorption behavior of HPF can be tuned on biomedically interesting materials by introducing a nano-sized morphology while not modifying the stoichiometry/chemistry.
authors.affiliation: Institute of Solid State Physics, Friedrich Schiller University, Jena, Germany. jana.sommerfeld@uni-jena.de
authors.forename: Jana
authors.initials: J
authors.lastname: Sommerfeld
authors.forename: Jessica
authors.initials: J
authors.lastname: Richter
authors.forename: Raphael
authors.initials: R
authors.lastname: Niepelt
authors.forename: Stefanie
authors.initials: S
authors.lastname: Kosan
authors.forename: Thomas F
authors.initials: TF
authors.lastname: Keller
authors.forename: Klaus D
authors.initials: KD
authors.lastname: Jandt
authors.forename: Carsten
authors.initials: C
authors.lastname: Ronning
mesh_terms: D000327:Adsorption; D005340:Fibrinogen / Q000737:chemistry* / Q000378:metabolism; D006801:Humans; D018625:Microscopy, Atomic Force; D012825:Silicon / Q000737:chemistry* / Q000378:metabolism; D014025:Titanium / Q000737:chemistry* / Q000378:metabolism
chemical_list: C009495:titanium dioxide; D005340:Fibrinogen; D014025:Titanium; D012825:Silicon