title: Effect of the factor V Leiden mutation on the incidence and outcome of severe infection and sepsis.
abstract: Activation of coagulation frequently occurs in severe infection and sepsis and may contribute to the development of multiple organ dysfunction. Factor V Leiden is a relatively common mutation resulting in a mild prohaemostatic state and consequently with an increased tendency to develop thrombosis. Hypothetically, patients with factor V Leiden may suffer from more severe coagulopathy in case of severe infection or sepsis. Aggravation of the procoagulant state in sepsis may subsequently result in more severe organ dysfunction and an increased risk of death. Here we discuss the experimental and clinical evidence regarding the relationship between the presence of a factor V Leiden mutation and the incidence and outcome of sepsis.
authors.affiliation: Department of Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.
authors.forename: M
authors.initials: M
authors.lastname: Schouten
authors.forename: C
authors.initials: C
authors.lastname: van 't Veer
authors.forename: T
authors.initials: T
authors.lastname: van der Poll
authors.forename: M
authors.initials: M
authors.lastname: Levi
mesh_terms: D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D005165:Factor V / Q000235:genetics*; D006801:Humans; D015994:Incidence; D009154:Mutation; D018805:Sepsis / Q000188:drug therapy* / Q000453:epidemiology*; D016896:Treatment Outcome
chemical_list: D000900:Anti-Bacterial Agents; C095381:factor V Leiden; D005165:Factor V