title: Dynamics and efficiency of hole transport in LNA:DNA hybrid diblock oligomers.
abstract: We report here the effect of replacing one or both of the purine or pyrimidine blocks of a diblock stilbene donor-acceptor capped hairpin with locked nucleic acid (LNA) bases on the dynamics and efficiency of hole transport. The structures of the DNA and LNA:DNA hybrids are tentatively assigned to B- or A-type structures on the basis of their circular dichroism spectra. Replacing the bases in either the A-block or the G-block of the diblock DNA hairpin with LNA bases results in a modest decrease in the base-to-base hopping rate constant and quantum yield for charge separation. Somewhat larger decreases are observed when all of the purine or pyrimidine bases are replaced by LNA bases.
authors.affiliation: Department of Chemistry and Argonne-Northwestern Solar Energy Research Center, Northwestern University, Evanston, Illinois 60208, USA.
authors.forename: Arun K
authors.initials: AK
authors.lastname: Thazhathveetil
authors.forename: Josh
authors.initials: J
authors.lastname: Vura-Weis
authors.forename: Anton
authors.initials: A
authors.lastname: Trifonov
authors.forename: Michael R
authors.initials: MR
authors.lastname: Wasielewski
authors.forename: Frederick D
authors.initials: FD
authors.lastname: Lewis
mesh_terms: D004247:DNA / Q000737:chemistry* / Q000235:genetics; D055029:Inverted Repeat Sequences; D056004:Molecular Dynamics Simulation; D009690:Nucleic Acid Conformation; D009693:Nucleic Acid Hybridization; D009841:Oligonucleotides / Q000737:chemistry* / Q000235:genetics
chemical_list: D009841:Oligonucleotides; C477371:locked nucleic acid; D004247:DNA