title: Relationship of serum osteocalcin levels with blood glucose, insulin resistance and lipid profile in central Indian men with type 2 diabetes.
abstract: OBJECTIVE
  To assess the relationship of serum osteocalcin levels with blood glucose, insulin resistance and lipid profile in central Indian men with type 2 diabetes.
  
  
  METHODS
  Anthropometric and biochemical parameters were measured in 56 newly diagnosed type 2 diabetic men and in 56 age and body mass index (BMI) matched controls. Insulin resistance was calculated by homeostasis model assessment of insulin resistance (HOMA-IR).
  
  
  RESULTS
  After adjustment for age and BMI, osteocalcin levels were negatively correlated with fasting plasma glucose (p = 0.0004), fasting insulin (p = 0.0311), HOMA-IR (p = 0.0023), and triglycerides (p = 0.0095), and positively correlated with high density lipoprotein (HDL)-cholesterol (p = 0.0042) in type 2 diabetic patients. In multivariate logistic regression analyses that adjusted for age, BMI, waist circumference and waist-to-hip ratio, osteocalcin was inversely associated with the presence of type 2 diabetes (p < 0.0001).
  
  
  CONCLUSIONS
  Osteocalcin may play a protective role in the pathogenesis of type 2 diabetes, not only through direct involvement in glucose homeostasis, but also through improving lipid profile.
authors.affiliation: Department of Biochemistry, MGM Medical College, Madhya Pradesh, India.
authors.forename: Purnima Dey
authors.initials: PD
authors.lastname: Sarkar
authors.forename: Anil Baran
authors.initials: AB
authors.lastname: Choudhury
mesh_terms: D001786:Blood Glucose / Q000378:metabolism*; D003924:Diabetes Mellitus, Type 2 / Q000097:blood* / Q000378:metabolism* / Q000503:physiopathology; D005215:Fasting / Q000097:blood; D006801:Humans; D007194:India; D007333:Insulin Resistance; D050356:Lipid Metabolism; D008297:Male; D008875:Middle Aged; D015675:Osteocalcin / Q000097:blood*
chemical_list: D001786:Blood Glucose; D015675:Osteocalcin