title: Diagnostic power of the mid-regional pro-atrial natriuretic peptide for heart failure patients with dyspnea: a meta-analysis.
abstract: OBJECTIVE
  To evaluate the diagnostic performance of the mid-regional portion of the pro-atrial natriuretic peptide (MR-proANP) for heart failure (HF) in dyspnea patients.
  
  
  METHODS
  We performed a systematic review of English-language studies published during the past three decades. The performance characteristics (diagnostic sensitivity, specificity, and other measures of accuracy) were pooled and examined by random-effects models.
  
  
  RESULTS
  Five studies met the inclusion criteria, which included 1153 patients with HF and 1904 non-HF patients. The summary estimates for MR-proANP in HF diagnosis had a diagnostic sensitivity of 0.90 (95% confidence interval (CI), 0.88-0.92), a specificity of 0.68 (95% CI, 0.66-0.70), and a diagnostic odds ratio (DOR) of 22.89 (95% CI, 12.54-41.77). The area under the curve (AUC) and Q value for the summary receiver operating characteristic (sROC) curves were 0.88 and 0.81, respectively.
  
  
  CONCLUSIONS
  MR-proANP showed a high diagnostic accuracy for HF in dyspnea patients.
authors.affiliation: Department of Laboratory Medicine, General Hospital of Ji'nan Military Command Region, Ji'nan 250031, China.
authors.forename: Zhide
authors.initials: Z
authors.lastname: Hu
authors.forename: Zhijun
authors.initials: Z
authors.lastname: Han
authors.forename: Yuanlan
authors.initials: Y
authors.lastname: Huang
authors.forename: Yi
authors.initials: Y
authors.lastname: Sun
authors.forename: Bo
authors.initials: B
authors.lastname: Li
authors.forename: Anmei
authors.initials: A
authors.lastname: Deng
mesh_terms: D009320:Atrial Natriuretic Factor / Q000737:chemistry* / Q000378:metabolism*; D004417:Dyspnea / Q000150:complications* / Q000175:diagnosis*; D006333:Heart Failure / Q000150:complications* / Q000175:diagnosis*; D006801:Humans; D012372:ROC Curve; D058028:Research Report; D012680:Sensitivity and Specificity
chemical_list: D009320:Atrial Natriuretic Factor