title: Sleep deprivation alters phosphorylated CREB levels in the amygdala: relationship with performance in a fear conditioning task.
abstract: We investigated the relationship between deficits in fear memory induced by sleep deprivation and pCREB expression in the basal and central nuclei of the amygdala. Sleep deprivation reduced pCREB expression in the central nucleus compared to control or sleep recovered groups, and in the basal nucleus only compared to sleep recovered group. Moreover, 24h of sleep recovery prior to training prevented changes in both pCREB expression and performance.
authors.affiliation: Departamento de Psicobiologia, Universidade Federal de São Paulo, São Paulo, SP, Brazil.
authors.forename: Nadine
authors.initials: N
authors.lastname: Pinho
authors.affiliation: Departamento de Psicobiologia, Universidade Federal de São Paulo, São Paulo, SP, Brazil.
authors.forename: Karin Monteiro
authors.initials: KM
authors.lastname: Moreira
authors.affiliation: Departamento de Psicobiologia, Universidade Federal de São Paulo, São Paulo, SP, Brazil. Electronic address: dchipolide@unifesp.br.
authors.forename: Debora Cristina
authors.initials: DC
authors.lastname: Hipolide
authors.affiliation: Centro de Microscopia Eletrônica, Laboratório de Fisiopatologia Clínica e Experimental, Universidade Federal de São Paulo, São Paulo, SP, Brazil.
authors.forename: Rita
authors.initials: R
authors.lastname: Sinigaglia-Coimbra
authors.affiliation: Mathematics, Computation and Cognition Center, Universidade Federal do ABC, Santo Andre, SP, Brazil.
authors.forename: Tatiana Lima
authors.initials: TL
authors.lastname: Ferreira
authors.affiliation: Research Imaging Centre, Center for Addiction and Mental Health, Toronto, Canada.
authors.forename: José N
authors.initials: JN
authors.lastname: Nobrega
authors.affiliation: Departamento de Psicobiologia, Universidade Federal de São Paulo, São Paulo, SP, Brazil.
authors.forename: Sergio
authors.initials: S
authors.lastname: Tufik
authors.affiliation: Departamento de Psicobiologia, Universidade Federal de São Paulo, São Paulo, SP, Brazil.
authors.forename: Maria Gabriela Menezes
authors.initials: MGM
authors.lastname: Oliveira
mesh_terms: D000679:Amygdala / Q000378:metabolism*; D000818:Animals; D003213:Conditioning, Psychological / Q000502:physiology*; D017362:Cyclic AMP Response Element-Binding Protein / Q000378:metabolism*; D005239:Fear / Q000502:physiology*; D007150:Immunohistochemistry; D008297:Male; D008568:Memory / Q000502:physiology; D010766:Phosphorylation; D011597:Psychomotor Performance / Q000502:physiology; D051381:Rats; D017208:Rats, Wistar; D012892:Sleep Deprivation
chemical_list: D017362:Cyclic AMP Response Element-Binding Protein