title: Association of topical amphotericin B lipid complex treatment to standard therapy for rhinomaxillary mucormycosis after liver transplantation: a case report.
abstract: Solid organ transplantation is becoming increasingly more common in the treatment of end-stage organ failure. The advent of newer immunosuppressive protocols and refined surgical techniques has allowed therapy to become standard care. Infection is a major and frequently life-threatening complication after transplantation and the incidence of opportunistic fungal infections in organ transplant recipients ranges from 2%-50% depending on the type of organ transplanted. We present a case of rhinomaxillary form of mucormycosis infection after liver transplantation. The succession of multiple risk factors in a torpid postoperative period was a key factor in the development of this disease. Multidisciplinary management with an early diagnosis, aggressive surgery, and intravenous and topical antifungal therapy care were definitive for the eradication of infection. The goal of the present report was to show efficacious management including the association of topical treatment with amphotericin B complex lipid to standard therapy and the absence of side effects.
authors.affiliation: Intensive Care Unit, Hospital Infanta Cristina, Badajoz, Spain. victoriatrasmontemartinez@hotmail.com
authors.forename: M V
authors.initials: MV
authors.lastname: Trasmonte
authors.forename: J D
authors.initials: JD
authors.lastname: Jiménez
authors.forename: M Á
authors.initials: MÁ
authors.lastname: Santiago
authors.forename: E
authors.initials: E
authors.lastname: Gálvez
authors.forename: V
authors.initials: V
authors.lastname: Jerez
authors.forename: D
authors.initials: D
authors.lastname: Pérez
authors.forename: M
authors.initials: M
authors.lastname: Robles
authors.forename: V K
authors.initials: VK
authors.lastname: Farje
authors.forename: P
authors.initials: P
authors.lastname: Martínez
authors.forename: P
authors.initials: P
authors.lastname: Nieto
authors.forename: J A
authors.initials: JA
authors.lastname: Rubio
mesh_terms: D000287:Administration, Topical; D000666:Amphotericin B / Q000008:administration & dosage* / Q000627:therapeutic use; D006801:Humans; D007571:Jaw Diseases / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D009091:Mucormycosis / Q000188:drug therapy*; D009668:Nose Diseases / Q000188:drug therapy*
chemical_list: D000666:Amphotericin B