title: Association of progranulin and high sensitivity CRP concentrations in gingival crevicular fluid and serum in chronic periodontitis subjects with and without obesity.
abstract: BACKGROUND
  Obesity is considered as a strong risk factor of inflammatory periodontal tissue destruction. The purpose of this study is to determine presence of progranulin (PGRN) and high sensitivity C reactive protein (hs CRP) levels in serum and gingival crevicular fluid (GCF) in obese subjects with chronic periodontitis and to find an association, if any.
  
  
  METHODS
  40 subjects (20 males and 20 females) were selected based on their clinical parameters into four groups (10 subjects in each group): group 1 (healthy non obese), group 2 (healthy obese), group 3 (non obese with chronic periodontitis) and group 4 (obese with chronic periodontitis). Serum and GCF PGRN levels were estimated by enzyme linked immunosorbant assay (ELISA) and hs CRP levels were estimated by immunoturbidimetry method.
  
  
  RESULTS
  The mean PGRN and hs CRP concentration both in serum and GCF were highest for group 4 followed by group 3, group 2 and least in Group 1.
  
  
  CONCLUSIONS
  PGRN and hs CRP may be novel biomarkers of the chronic inflammatory response in obesity and chronic periodontitis.
authors.affiliation: Department of Periodontics, Government Dental College and Research Institute, Bangalore, Karnataka, India. periodonticsgdcri@gmail.com
authors.forename: A R
authors.initials: AR
authors.lastname: Pradeep
authors.forename: N
authors.initials: N
authors.lastname: Priyanka
authors.forename: M V R
authors.initials: MV
authors.lastname: Prasad
authors.forename: Nitish
authors.initials: N
authors.lastname: Kalra
authors.forename: Minal
authors.initials: M
authors.lastname: Kumari
mesh_terms: D000328:Adult; D002097:C-Reactive Protein / Q000032:analysis*; D016022:Case-Control Studies; D055113:Chronic Periodontitis / Q000150:complications / Q000175:diagnosis / Q000378:metabolism*; D005260:Female; D005883:Gingival Crevicular Fluid / Q000737:chemistry; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins / Q000032:analysis* / Q000097:blood; D008297:Male; D009765:Obesity / Q000097:blood / Q000150:complications / Q000378:metabolism*; D000077153:Progranulins
chemical_list: C492314:GRN protein, human; D036341:Intercellular Signaling Peptides and Proteins; D000077153:Progranulins; D002097:C-Reactive Protein