title: Early administration of branched-chain amino acid granules.
abstract: The effect of malnutrition on survival in patients with decompensated liver cirrhosis has not been well defined. Nutritional intervention with branched-chain amino acid (BCAA) can increase serum albumin concentration in patients with decompensated cirrhosis but its effects on survival are unclear. The BCAA to tyrosine ratio (BTR) is a surrogate marker (the normal range of BTR is between 4.41 and 10.05, and a Fischer's ratio of 1.8 corresponds to a BTR of 3.5) in patients with decompensated liver cirrhosis, and BCAA inhibits hepatic carcinogenesis in patients with compensated cirrhosis. This review discusses data regarding the effect of early administration of BCAA granules based on the ratio of BCAA to BTR on prognosis in patients with cirrhosis.
authors.affiliation: Department of Gastroenterology and Hepatology, Saiseikai Niigata Daini Hospital, Niigata 950-1104, Japan. toruishi@ngt.saiseikai.or.jp
authors.forename: Toru
authors.initials: T
authors.lastname: Ishikawa
mesh_terms: D000597:Amino Acids, Branched-Chain / Q000627:therapeutic use*; D015415:Biomarkers / Q000097:blood; D006801:Humans; D008103:Liver Cirrhosis / Q000150:complications* / Q000175:diagnosis / Q000401:mortality; D008113:Liver Neoplasms / Q000517:prevention & control; D011379:Prognosis; D011502:Protein-Energy Malnutrition / Q000097:blood / Q000188:drug therapy* / Q000209:etiology*; D012709:Serum Albumin / Q000378:metabolism; D015996:Survival Rate; D013997:Time Factors; D014443:Tyrosine / Q000097:blood
chemical_list: D000597:Amino Acids, Branched-Chain; D015415:Biomarkers; D012709:Serum Albumin; D014443:Tyrosine