title: Hematopoietic stem cell transplantation and rhinosinusitis: the utility of screening sinus computed tomography.
abstract: OBJECTIVE
  To compare prehematopoietic stem cell transplantation (SCT) sinus computed tomography (CT) scans to post-SCT sinus CT scans and to evaluate the relationship between pre-SCT sinus CT scans and the incidence of otolaryngology consultation after SCT.
  
  
  METHODS
  Retrospective chart review.
  
  
  METHODS
  Charts of 228 adult SCT patients from January 2003 to June 2009 with pre-SCT sinus CT scans were reviewed. Data gathered included diagnosis, type of SCT, otolaryngology referral requests, and rhinosinusitis management. Pre- and post-SCT sinus CT scans were scored using the staging system introduced by Lund and Mackay.
  
  
  RESULTS
  Two hundred thirty-nine SCTs were performed on the 228 patients included in this study. No disease was identified on 25.1% of pre-SCT CT scans, mild sinus inflammation was identified on 60.7% of scans, 11.3% had moderate inflammation, and 2.9% had severe inflammation. Pre-SCT scans were found to be predictive of post-SCT CT scans. A significant proportion of patients demonstrated worsening of their Lund-Mackay score post-SCT. Pre-SCT CT scores had no predictive ability for otolaryngology consultations.
  
  
  CONCLUSIONS
  Pre-SCT CT scan scores are associated with post-SCT scan scores; disease severity on CT may worsen following SCT and may be useful for stratifying patients into surgical versus non-surgical candidates. Further study is needed to outline the benefit of sinus surgery in these patients.
authors.affiliation: Division of Rhinology and Sinus Surgery, Department of Otolaryngology and Communication Sciences, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA.
authors.forename: Susan
authors.initials: S
authors.lastname: Fulmer
authors.forename: Sung-won
authors.initials: SW
authors.lastname: Kim
authors.forename: Jess C
authors.initials: JC
authors.lastname: Mace
authors.forename: Matthew E
authors.initials: ME
authors.lastname: Leach
authors.forename: Sergey
authors.initials: S
authors.lastname: Tarima
authors.forename: Qun
authors.initials: Q
authors.lastname: Xiang
authors.forename: Zachary M
authors.initials: ZM
authors.lastname: Soler
authors.forename: Christopher
authors.initials: C
authors.lastname: Bredeson
authors.forename: Todd A
authors.initials: TA
authors.lastname: Loehrl
authors.forename: David M
authors.initials: DM
authors.lastname: Poetker
mesh_terms: D000328:Adult; D000368:Aged; D002908:Chronic Disease; D005260:Female; D018380:Hematopoietic Stem Cell Transplantation / Q000009:adverse effects*; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications; D015203:Reproducibility of Results; D012189:Retrospective Studies; D012220:Rhinitis / Q000000981:diagnostic imaging* / Q000453:epidemiology / Q000209:etiology; D012307:Risk Factors; D012720:Severity of Illness Index; D012852:Sinusitis / Q000000981:diagnostic imaging* / Q000453:epidemiology / Q000209:etiology; D014057:Tomography, X-Ray Computed / Q000706:statistics & numerical data*; D014481:United States / Q000453:epidemiology; D055815:Young Adult