title: Functional PLGA NPs for oral drug delivery: recent strategies and developments.
abstract: This article presents the potential of PLGA nanoparticles for the oral administration of drugs. Different strategies are used to improve oral absorption of these nanoparticles. These strategies are based on modification of nanoparticle surface properties. They can be achieved either by coating the nanoparticle surface with stabilizing hydrophilic bioadhesive polymers or surfactants, or by incorporating biodegradable copolymers containing a hydrophilic moiety. Some substances such as chitosan, vitamin E, methacrylates, lectins, lecithins, bile salts and RGD molecules are employed for this purpose. Of especial interest are nanoparticles production methods and, in order to improve oral bioavailability, the mechanism of each additive.
authors.affiliation: Departamento de Farmacia y Tecnología Farmacéutica, Facultad de Farmacia, Universidad de Sevilla, Sevilla, España. luciamartin@us.es
authors.forename: L
authors.initials: L
authors.lastname: Martin-Banderas
authors.forename: M
authors.initials: M
authors.lastname: Durán-Lobato
authors.forename: I
authors.initials: I
authors.lastname: Muñoz-Rubio
authors.forename: J
authors.initials: J
authors.lastname: Alvarez-Fuentes
authors.forename: M
authors.initials: M
authors.lastname: Fernández-Arevalo
authors.forename: M A
authors.initials: MA
authors.lastname: Holgado
mesh_terms: D000284:Administration, Oral; D000818:Animals; D004337:Drug Carriers / Q000737:chemistry*; D004738:Engineering; D006801:Humans; D019344:Lactic Acid / Q000737:chemistry*; D053758:Nanoparticles / Q000737:chemistry*; D011100:Polyglycolic Acid / Q000737:chemistry*; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer
chemical_list: D004337:Drug Carriers; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D011100:Polyglycolic Acid; D019344:Lactic Acid