title: Value of debridement and irrigation for the treatment of peri-prosthetic infections. A systematic review.
abstract: Debridement and irrigation has been proposed as a salvage procedure for early post-operative and late acute haematogenous periprosthetic hip and knee infections, however the effective ability of this procedure to avoid recurrent infection is still debated. In this systematic review of the literature we reviewed full-text papers published from 1970 through 2011, that reported the success rate of infection eradication after debridement and irrigation with prosthesis retention for the treatment of early septic complications (within six weeks from surgery) or late acute haematogenous infections after hip or knee prosthesis. In all, 14 original articles, reporting the results of 710 patients were retrieved. The average success rate has been, respectively, 45.9% and 52% after a single or repeated debridement and irrigation procedures, at a mean follow-up of 53.3 months. The methodological limitations of this study and the heterogeneous material in the reviewed papers notwithstanding, this systematic review shows that debridement and irrigation procedure is associated with a rather poor outcome, even in a population of patients selected on the basis of symptoms' duration and patients should be adequately informed prior to undergo this salvage procedure.
authors.affiliation: Centre for Reconstructive Surgery and Osteo-articular Infections, IRCCS Galeazzi Orthopaedic Institute, Milan - Italy. carlo.romano@grupposandonato.it
authors.forename: Carlo L
authors.initials: CL
authors.lastname: Romanò
authors.forename: Giovanni
authors.initials: G
authors.lastname: Manzi
authors.forename: Nicola
authors.initials: N
authors.lastname: Logoluso
authors.forename: Delia
authors.initials: D
authors.lastname: Romanò
mesh_terms: D019644:Arthroplasty, Replacement, Hip / Q000009:adverse effects; D019645:Arthroplasty, Replacement, Knee / Q000009:adverse effects; D003646:Debridement / Q000379:methods*; D006621:Hip Joint / Q000382:microbiology / Q000601:surgery*; D006622:Hip Prosthesis / Q000382:microbiology; D006801:Humans; D017053:Infection Control / Q000379:methods*; D007719:Knee Joint / Q000382:microbiology / Q000601:surgery*; D007720:Knee Prosthesis / Q000382:microbiology; D023821:Limb Salvage / Q000379:methods*; D011475:Prosthesis Failure; D016459:Prosthesis-Related Infections / Q000209:etiology / Q000601:surgery*; D055502:Secondary Prevention; D007507:Therapeutic Irrigation; D016896:Treatment Outcome