title: A microwave promoted solvent-free approach to steroidal quinolines and their in vitro evaluation for antimicrobial activities.
abstract: The preparation of A-ring and D-ring fused steroidal quinolines is described from one-pot reaction of steroidal β-bromovinylaldehydes and arylamines in solvent-free and catalyst-free condition under microwave irradiation. The antimicrobial activities of the compounds were tested by agar diffusion assay and broth macro dilution method. Compounds 7a, 7e and 7g-h showed promising in vitro activity when tested against fungal pathogen Aspergillus niger whereas compounds 7e-h and 7j showed promising activity when tested against fungal pathogen Candida albicans. Compounds 7c and 7f showed potent inhibition against the growth of Gram negative bacteria Pseudomonas aeruginosa and compounds 7e, 7g-h and 7j inhibited the growth of tested Gram positive bacteria Bacillus subtilis and Staphylococcus aureus.
authors.affiliation: Medicinal Chemistry Division, CSIR-North East Institute of Science and Technology, Jorhat 785006, India.
authors.forename: Shyamalee
authors.initials: S
authors.lastname: Gogoi
authors.forename: Kommuri
authors.initials: K
authors.lastname: Shekarrao
authors.forename: Aparajita
authors.initials: A
authors.lastname: Duarah
authors.forename: Tarun C
authors.initials: TC
authors.lastname: Bora
authors.forename: Sanjib
authors.initials: S
authors.lastname: Gogoi
authors.forename: Romesh C
authors.initials: RC
authors.lastname: Boruah
mesh_terms: D000890:Anti-Infective Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects; D060326:Chemistry Techniques, Synthetic; D005658:Fungi / Q000187:drug effects; D055772:Green Chemistry Technology / Q000379:methods*; D008826:Microbial Sensitivity Tests; D008872:Microwaves; D011804:Quinolines / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D013256:Steroids / Q000737:chemistry*
chemical_list: D000890:Anti-Infective Agents; D011804:Quinolines; D013256:Steroids