title: Altered expression levels of HLA class Ⅱ and costimulatory molecules             on circulating monocytes from patients with cervical intraepithelial neoplasia             and squamous cervical cancer.
abstract: The aim of this study was to investigate the role of the cell surface expression             levels of HLA class I and II molecules, the costimulatory molecules CD80/B7-1             and CD86/B7-2, and the adhesion molecules CD54 and CD58 during cervical carcinogenesis.             The expression levels of MHC class I and II molecules, the costimulatory molecules             CD80/B7-1 and CD86/B7-2 and the adhesion molecules CD54 and CD58 on CD14+ peripheral             blood monocytes (PBMs) from 21 cases of cervical intraepithelial neoplasia (CIN)             II-III, 51 squamous cervical carcinomas (SCCs) and 18 healthy controls were analyzed             using flow cytometry analysis. We found increased expression levels of HLA-DR             (p=0.000), HLA-DQ (p=0.000), CD86/B7-2 (p=0.002) and CD58 (p=0.000) on PBMs from             patients with SCC and CIN II-III, compared with healthy control subjects, whereas             no significant difference existed in the expression levels of HLA class I antigens,             HLA-DP CD80/B7-1 and CD54. Upregulated expression levels of HLA-DR, HLA-DQ, CD86/B7-2             and CD58 were associated with disease progression, indicating that an increased             expression of HLA-DR, HLA-DQ, CD86/B7-2 and CD58 on PBMs may be correlated with             the evolution of cervical cancer.
authors.affiliation: Department of Gynecologic Oncology, Women's Hospital, School                     of Medicine, Zhejiang University, Hangzhou 310006, P.R. China.
authors.forename: Ting
authors.initials: T
authors.lastname: Feng
authors.forename: Jian-Hong
authors.initials: JH
authors.lastname: Zhou
authors.forename: Jia
authors.initials: J
authors.lastname: Liu
authors.forename: Feng
authors.initials: F
authors.lastname: Ye
authors.forename: Weiguo
authors.initials: W
authors.lastname: Lu
authors.forename: Xing
authors.initials: X
authors.lastname: Xie
mesh_terms: D000328:Adult; D018122:B7-1 Antigen / Q000378:metabolism; D051940:B7-2 Antigen / Q000378:metabolism; D018968:CD58 Antigens / Q000378:metabolism; D002294:Carcinoma, Squamous Cell / Q000378:metabolism* / Q000473:pathology; D005260:Female; D006683:HLA-DQ Antigens / Q000378:metabolism; D006684:HLA-DR Antigens / Q000378:metabolism; D000949:Histocompatibility Antigens Class II / Q000378:metabolism*; D006801:Humans; D018799:Intercellular Adhesion Molecule-1 / Q000378:metabolism; D008875:Middle Aged; D009000:Monocytes / Q000166:cytology / Q000378:metabolism*; D015854:Up-Regulation; D002583:Uterine Cervical Neoplasms / Q000378:metabolism* / Q000473:pathology; D002578:Uterine Cervical Dysplasia / Q000378:metabolism* / Q000473:pathology
chemical_list: D018122:B7-1 Antigen; D051940:B7-2 Antigen; D018968:CD58 Antigens; C497964:CD86 protein, human; D006683:HLA-DQ Antigens; D006684:HLA-DR Antigens; D000949:Histocompatibility Antigens Class II; D018799:Intercellular Adhesion Molecule-1