title: [Type 2 diabetes--a heterogeneous disease with a foetal predisposition].
abstract: Type 2 diabetes (T2D) is a heterogeneous disease with a multifactorial aetiology involving defects in the pancreatic beta cells, liver, muscles, adipose tissue, guts, brain, kidneys and heart. While genetics may only explain a minor proportion of T2D, the contribution of an adverse intrauterine environment may take centre stage in the global propagation of T2D. Impaired expandability of subcutaneous adipose tissue in persons with low birthweight may cause T2D due to lipotoxicity in non-adipose organs. Future implications include a stronger focus on individualized treatments in T2D patients and prevention of T2D in the next generations.
authors.affiliation: Medicinsk Endokrinologisk Klinik, Rigshospitalet, Blegdamsvej 9, 2100 København Ø, Denmark. allan.vaag@rh.regionh.dk
authors.forename: Allan
authors.initials: A
authors.lastname: Vaag
mesh_terms: D000273:Adipose Tissue / Q000378:metabolism; D015984:Causality; D019175:DNA Methylation; D003924:Diabetes Mellitus, Type 2 / Q000209:etiology* / Q000235:genetics / Q000378:metabolism / Q000503:physiopathology; D044127:Epigenesis, Genetic; D020022:Genetic Predisposition to Disease; D005838:Genotype; D055451:Growth Differentiation Factor 3 / Q000235:genetics / Q000378:metabolism; D006360:Heat-Shock Proteins / Q000235:genetics; D006801:Humans; D007230:Infant, Low Birth Weight / Q000378:metabolism; D007231:Infant, Newborn; D050356:Lipid Metabolism; D035683:MicroRNAs / Q000378:metabolism; D000071248:Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; D010641:Phenotype; D012307:Risk Factors; D014157:Transcription Factors / Q000235:genetics
chemical_list: D055451:Growth Differentiation Factor 3; D006360:Heat-Shock Proteins; C548912:MIRN483 microRNA, human; D035683:MicroRNAs; C486497:PPARGC1A protein, human; D000071248:Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; D014157:Transcription Factors