title: Germinal center kinases in immune regulation.
abstract: Germinal center kinases (GCKs) participate in a variety of signaling pathways needed to regulate cellular functions including apoptosis, cell proliferation, polarity and migration. Recent studies have shown that GCKs are participants in both adaptive and innate immune regulation. However, the differential activation and regulatory mechanisms of GCKs, as well as upstream and downstream signaling molecules, remain to be fully defined. It remains unresolved whether and how GCKs may cross-talk with existing signaling pathways. This review stresses the progresses in research of GCKs relevant to the immune system.
authors.affiliation: Department of Trauma and Orthopaedics, General Hospital of Jinan Military Region, Jinan, China.
authors.forename: Hailei
authors.initials: H
authors.lastname: Yin
authors.forename: Zhubing
authors.initials: Z
authors.lastname: Shi
authors.forename: Shi
authors.initials: S
authors.lastname: Jiao
authors.forename: Cuicui
authors.initials: C
authors.lastname: Chen
authors.forename: Wenjia
authors.initials: W
authors.lastname: Wang
authors.forename: Mark I
authors.initials: MI
authors.lastname: Greene
authors.forename: Zhaocai
authors.initials: Z
authors.lastname: Zhou
mesh_terms: D000818:Animals; D000081410:Germinal Center Kinases; D006801:Humans; D007109:Immunity / Q000276:immunology*; D007249:Inflammation / Q000276:immunology / Q000473:pathology; D008214:Lymphocytes / Q000166:cytology / Q000201:enzymology / Q000276:immunology; D018448:Models, Immunological; D017346:Protein Serine-Threonine Kinases / Q000276:immunology*; D015398:Signal Transduction / Q000276:immunology
chemical_list: D000081410:Germinal Center Kinases; D017346:Protein Serine-Threonine Kinases