title: [Research progress of the anti-HIV activity of SAMHD1].
abstract: The SAM and HD domain containing protein 1 (Sterile alpha motif domain and HD domain-containing protein 1, SAMHD1) is a putative negative regulator of the antiviral innate immune response. It can significantly increase the antiviral immune response, mediates the interferon-induced inflammatory response involved in the host foreign-virus defense system. The early studies have focused on its gene mutations associated with Aicardi-Goutières syndrome (AGS), the latest study found that SAMHD1 as a potent dGTP-stimulated triphosphohydrolase restricts HIV-1 replication by hydrolyzing the majority of cellular dNTPs, thus inhibiting reverse transcription and viral complementary DNA (cDNA) synthesis. Auxiliary gene of HIV-2 and simian immunodeficiency virus (SIVsm / mac) encoding the Vpx protein can eliminate HIV-1 restriction. In recent years, the research on SAMHD1, mores forward rapidly this paper overviews the recent research progression related to the above fields.
authors.affiliation: Shanghai Public Health Clinical Center Affiliated to Fudan University, Institutes of Biomedical Sciences, Fudan University, Shanghai 201508, China.
authors.forename: Jun
authors.initials: J
authors.lastname: Huang
authors.forename: Chao
authors.initials: C
authors.lastname: Qiu
authors.forename: Xiao-Yan
authors.initials: XY
authors.lastname: Zhang
mesh_terms: D000818:Animals; D002460:Cell Line; D006678:HIV / Q000378:metabolism / Q000502:physiology*; D006801:Humans; D020559:Monomeric GTP-Binding Proteins / Q000235:genetics / Q000378:metabolism*; D000076106:SAM Domain and HD Domain-Containing Protein 1; D054334:Viral Regulatory and Accessory Proteins / Q000378:metabolism
chemical_list: D054334:Viral Regulatory and Accessory Proteins; D000076106:SAM Domain and HD Domain-Containing Protein 1; C484280:SAMHD1 protein, human; D020559:Monomeric GTP-Binding Proteins