title: Vascular endothelial growth factor +936C/T polymorphism and gastric cancer risk: A meta-analysis.
abstract: The aim of this study was to determine whether the vascular endothelial growth factor (VEGF) +936C/T polymorphism confers susceptibility to gastric cancer (GC) by conducting a meta-analysis. Publications addressing the association between the VEGF +936C/T polymorphism and GC risk were selected from the Pubmed, Embase and CBM databases. Data were extracted from the studies by two independent reviewers. The meta-analysis was performed using RevMan 5.0.25 and STATA 9.2 software. From these data, the odds ratio (OR) with 95% confidence interval (CI) was calculated. Finally, 8 case-control studies were retrieved reporting a total of 2,131 gastrointestinal cancer patients and 2,670 controls. Meta-analysis results showed that there was no significant association between the VEGF +936C/T polymorphism and GC risk in all comparisons of the T allele vs. C allele (OR=1.08, 95% CI 0.90-1.30, P=0.42), CT+TT vs. CC (OR=1.08, 95% CI 0.87-1.34, P=0.49), TT vs. CC+CT (OR=1.14, 95% CI 0.85-1.53, P=0.37), TT vs. CC (OR=1.18, 95% CI 0.87-1.59, P=0.28) and TT vs. CT (OR=1.11, 95% CI 0.79-1.56, P=0.56). This meta-analysis confirms that there is a lack of association between the VEGF +936C/T polymorphism and GC risk.
authors.affiliation: Department of Laboratory Medicine, The First Hospital of China Medical University, Shenyang 110001, P.R.  China.
authors.forename: Li-Ping
authors.initials: LP
authors.lastname: Zhou
authors.forename: Hong
authors.initials: H
authors.lastname: Luan
authors.forename: Xin-Hua
authors.initials: XH
authors.lastname: Dong
authors.forename: Guo-Jiang
authors.initials: GJ
authors.lastname: Jin
authors.forename: Dong-Liang
authors.initials: DL
authors.lastname: Man
authors.forename: Hong
authors.initials: H
authors.lastname: Shang