title: Complications of total hip replacement.
abstract: OBJECTIVE
  To determine the factors causing complications in unilateral total hip replacement.
  
  
  METHODS
  Analytical study.
  
  
  METHODS
  The Aga Khan University Hospital, Karachi, between 2000 and 2010.
  
  
  METHODS
  During the study period, 199 patients underwent elective unilateral total hip replacement at the Aga Khan University Hospital. Patients were divided into two groups on the basis of postoperative complications within 30 days of surgery. Significant factors at 5% significance level on univariate analysis were further analyzed by multivariate logistic regression.
  
  
  RESULTS
  Postoperative complications occurred in 39 patients (19.6%); dislocation being most common in 13 patients (6.5%), followed by wound infection in four (2%), all of these patients required intervention. Other minor complications which were managed conservatively included wound infection (2.5%), urinary tract infection (2.5%), dislocation (1%), pleural effusion and pneumonia (2%), deep venous thrombosis (0.5%) and myocardial infarction (0.5%). On univariate analysis, patients with ASA III and IV, peri-operative blood transfusion, pre-operative hip deformity and post-operative bisphosphonate use were significantly associated with complications. On multi-variate analysis, adjusted odd's ratio for perioperative transfusion (3; 95% CI: 1.17-7.7) and hip deformity (3.2, 95% CI: 1.4-3.4) was found statistically significant.
  
  
  CONCLUSIONS
  Pre-operative hip deformity and perioperative blood transfusion significantly influence the rates of complication after unilateral THR.
authors.affiliation: Department of Surgery, The Aga Khan University Hospital, Karachi.
authors.forename: Kashif
authors.initials: K
authors.lastname: Abbas
authors.forename: Ghulam
authors.initials: G
authors.lastname: Murtaza
authors.forename: Masood
authors.initials: M
authors.lastname: Umer
authors.forename: Haroon
authors.initials: H
authors.lastname: Rashid
authors.forename: Irfan
authors.initials: I
authors.lastname: Qadir
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D019645:Arthroplasty, Replacement, Knee / Q000009:adverse effects*; D001803:Blood Transfusion / Q000706:statistics & numerical data; D015992:Body Mass Index; D017558:Elective Surgical Procedures / Q000009:adverse effects*; D005260:Female; D006785:Hospitals, University; D006801:Humans; D007902:Length of Stay; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D016017:Odds Ratio; D010154:Pakistan; D019990:Perioperative Care; D011183:Postoperative Complications; D012189:Retrospective Studies; D012307:Risk Factors; D013530:Surgical Wound Infection / Q000453:epidemiology / Q000209:etiology*; D065227:Transfusion Reaction; D016896:Treatment Outcome; D020246:Venous Thrombosis / Q000150:complications / Q000209:etiology