title: First polymorphisms in JY-1 gene in cattle (Bos taurus indicus) and their association with sexual precocity and growth traits.
abstract: Protein JY-1 is a bovine oocyte-specific protein that regulates granulosa cell function and is involved in early embryonic development, influencing the chance of pregnancy. This study investigated molecular markers for the JY-1 gene. Seven SNPs were identified in exon 3 of the gene. The positions of the SNPs in the exon and the respective substitutions are: 163 (T/C), 281 (T/C), 321 (T/C), 532 (T/C), 652 (A/G), 679 (T/C), and 722 (G/C) (GenBank: JN592587 and JF262042.2). SNP 163 is located in a coding region and causes a proline-to-leucine substitution. The other SNPs are located in the 3'UTR region. SNPs 163, 281, 321, and 679 were genotyped in 297 Nellore heifers and the haplotypes were constructed. The haplotypes of JY-1 were not correlated with the traits studied at 5 %.
authors.affiliation: São Paulo State University, Jaboticabal, Brazil. gregoriocamargo@hotmail.com
authors.forename: Gregório Miguel Ferreira
authors.initials: GM
authors.lastname: de Camargo
authors.forename: Diercles Francisco
authors.initials: DF
authors.lastname: Cardoso
authors.forename: Fernanda Maria Monsalves
authors.initials: FM
authors.lastname: Gil
authors.forename: Patrícia Dias da Silva
authors.initials: PD
authors.lastname: Fonseca
authors.forename: Larissa
authors.initials: L
authors.lastname: Zetouni
authors.forename: Camila Urbano
authors.initials: CU
authors.lastname: Braz
authors.forename: Ana Claudia
authors.initials: AC
authors.lastname: de Freitas
authors.forename: Fábio Ricardo Pablos
authors.initials: FR
authors.lastname: de Souza
authors.forename: Rusbel Raul
authors.initials: RR
authors.lastname: Aspilcueta-Borquis
authors.forename: Fernando
authors.initials: F
authors.lastname: Baldi
authors.forename: Lucia Galvão
authors.initials: LG
authors.lastname: de Albuquerque
authors.forename: Luciana Correia de Almeida
authors.initials: LC
authors.lastname: Regitano
authors.forename: Humberto
authors.initials: H
authors.lastname: Tonhati
mesh_terms: D019943:Amino Acid Substitution; D000818:Animals; D002417:Cattle / Q000235:genetics* / Q000254:growth & development / Q000502:physiology; D004527:Egg Proteins / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D006239:Haplotypes; D008297:Male; D008969:Molecular Sequence Data; D020641:Polymorphism, Single Nucleotide; D011247:Pregnancy; D011629:Puberty, Precocious / Q000235:genetics*; D017422:Sequence Analysis, DNA; D015430:Weight Gain / Q000235:genetics
chemical_list: D004527:Egg Proteins