title: Target-based selection of flavonoids for neurodegenerative disorders.
abstract: Habitual consumption of dietary flavonoids known to improve mitochondrial bioenergetics and inhibit various secondary sources of reactive oxygen species (ROS) reduces the risk for neurodegenerative disorders such as Parkinson's disease (PD), stroke, and Alzheimer's disease (AD). Combining specific dietary flavonoids selected on the basis of oral bioavailability, brain penetration, and the inhibition of multiple processes responsible for excessive ROS production may be a viable approach for the prevention and treatment of neurodegenerative disorders. Inclusion of flavonoids that raise cAMP levels in the brain may be of additional benefit by reducing the production of proinflammatory mediators and stimulating the transcriptional machinery necessary for mitochondrial biosynthesis. Preclinical models suggest that flavonoids reduce hearing loss resulting from treatment with the chemotherapeutic drug cisplatin by opposing the excessive production of ROS and proinflammatory mediators implicated in PD, stroke, and AD. Flavonoid combinations optimized for efficacy in models of cisplatin-induced hearing loss (CIHL) may therefore have therapeutic utility for neurodegenerative disorders.
authors.affiliation: Department of Pharmacology, Faculty of Medicine, 1459 Oxford Street, Dalhousie University, Halifax, Nova Scotia, Canada B3H 4R2.
authors.forename: Quinton R D
authors.initials: QR
authors.lastname: Jones
authors.forename: Jordan
authors.initials: J
authors.lastname: Warford
authors.forename: H P Vasantha
authors.initials: HP
authors.lastname: Rupasinghe
authors.forename: George S
authors.initials: GS
authors.lastname: Robertson
mesh_terms: D000544:Alzheimer Disease / Q000188:drug therapy*; D000818:Animals; D002945:Cisplatin / Q000633:toxicity; D005419:Flavonoids / Q000737:chemistry / Q000493:pharmacokinetics / Q000494:pharmacology / Q000627:therapeutic use*; D006801:Humans; D008928:Mitochondria / Q000378:metabolism; D010300:Parkinson Disease / Q000188:drug therapy*; D017382:Reactive Oxygen Species / Q000037:antagonists & inhibitors / Q000378:metabolism
chemical_list: D005419:Flavonoids; D017382:Reactive Oxygen Species; D002945:Cisplatin