title: Plasma cytokines in polycythemia vera: phenotypic correlates, prognostic relevance, and comparison with myelofibrosis.
abstract: Plasma cytokine milieu is abnormal in primary myelofibrosis (PMF) and correlates with disease phenotype and prognosis. In this study, we show that several plasma cytokines are also abnormally expressed in polycythemia vera (PV; n = 65), compared to normal controls (n = 35), but with a significantly different pattern than that of PMF (n = 127). Direct phenotypic correlation in PV included levels of IL-12 with hematocrit; IL-1b, IL-2, IL-7, FGF-b, and HGF with leukocytosis; and IFN-α and IFN-γ with thrombocytosis. In univariate analysis, levels of 13 cytokines (out of 30 analyzed) correlated with survival but only MIP-1β remained significant on multivariable analysis that included the other cytokines as covariates. Increased level of MIP-1β (P < 0.01), older age (P < 0.01), and leukocytosis (P = 0.03) maintained their association with shortened survival, on multivariable analysis. This study provides preliminary observations that warrant a larger scale study and suggests the value of plasma cytokines as prognostic biomarkers in PV.
authors.affiliation: Division of Hematology, Department of Internal Medicine, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA.
authors.forename: Rakhee
authors.initials: R
authors.lastname: Vaidya
authors.forename: Naseema
authors.initials: N
authors.lastname: Gangat
authors.forename: Thitina
authors.initials: T
authors.lastname: Jimma
authors.forename: Christy M
authors.initials: CM
authors.lastname: Finke
authors.forename: Terra L
authors.initials: TL
authors.lastname: Lasho
authors.forename: Animesh
authors.initials: A
authors.lastname: Pardanani
authors.forename: Ayalew
authors.initials: A
authors.lastname: Tefferi
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015415:Biomarkers / Q000097:blood; D016022:Case-Control Studies; D016207:Cytokines / Q000097:blood*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D053208:Kaplan-Meier Estimate; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D010641:Phenotype; D011087:Polycythemia Vera / Q000097:blood* / Q000276:immunology / Q000401:mortality; D011237:Predictive Value of Tests; D055728:Primary Myelofibrosis / Q000097:blood* / Q000276:immunology / Q000401:mortality; D011379:Prognosis; D016016:Proportional Hazards Models
chemical_list: D015415:Biomarkers; D016207:Cytokines