title: Gelator-polysaccharide hybrid hydrogel for selective and controllable dye release.
abstract: In this paper, 1,4-bi(phenylalanine-diglycol)-benzene (PDB) based Low-Molecular-Weight-Gelator (LMWG) hydrogels are modified using hydrophilic polysaccharide (sodium alginate). A set of techniques including Fourier transform infrared (FT-IR) spectroscopy, (1)H Nuclear Magnetic Resonance ((1)H NMR), X-ray powder diffraction (XRD), Ultraviolet-Visible (UV-Vis), and circular dichroism (CD) had confirmed a β-turn arrangement of PDB gelators and a semi-interpenetrating network (semi-IPN), which was formed through hydrogen bonds between LMWG fibers and polysaccharide chains. The evaluation of physicochemical properties of hydrogels indicates that gelator-polysaccharide hybrid hydrogels possess better mechanical and water retention properties than LMWG hydrogels. The release study of dyes (model drug) from both LMWG and hybrid hydrogels was carried out. Compared with PDB based hydrogels, hybrid hydrogels show a selective and controllable release property for certain dyes. The results suggest LMWG-polysaccharide hybrid gels may find potential applications as promising drug delivery vehicles for drug molecules.
authors.affiliation: State Key Lab of Metal Matrix Composites, School of Materials Science and Engineering, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai 200240, China.
authors.forename: Ping
authors.initials: P
authors.lastname: Li
authors.forename: Xiao-Qiu
authors.initials: XQ
authors.lastname: Dou
authors.forename: Yi-Tian
authors.initials: YT
authors.lastname: Tang
authors.forename: Shenmin
authors.initials: S
authors.lastname: Zhu
authors.forename: Jiajun
authors.initials: J
authors.lastname: Gu
authors.forename: Chuan-Liang
authors.initials: CL
authors.lastname: Feng
authors.forename: Di
authors.initials: D
authors.lastname: Zhang
mesh_terms: D000464:Alginates / Q000737:chemistry*; D004396:Coloring Agents / Q000008:administration & dosage*; D003692:Delayed-Action Preparations / Q000737:chemistry*; D020723:Glucuronic Acid / Q000737:chemistry; D006603:Hexuronic Acids / Q000737:chemistry; D020100:Hydrogels / Q000737:chemistry*; D006860:Hydrogen Bonding; D009682:Magnetic Resonance Spectroscopy; D010649:Phenylalanine / Q000031:analogs & derivatives / Q000737:chemistry; D017550:Spectroscopy, Fourier Transform Infrared; D014961:X-Ray Diffraction
chemical_list: D000464:Alginates; D004396:Coloring Agents; D003692:Delayed-Action Preparations; D006603:Hexuronic Acids; D020100:Hydrogels; D010649:Phenylalanine; D020723:Glucuronic Acid