title: Pituitary dysfunction in survivors of spontaneous subarachnoid hemorrhage of anterior communicating artery and middle cerebral artery aneurysms: A comparative study.
abstract: BACKGROUND
  The data on incidence of hypopituitarism after SAH are conflicting. Furthermore, it is still not known whether there is any difference in hormonal deficiencies between SAH due to anterior communicating artery (A-com) and middle cerebral artery (MCA) aneurysms.
  
  
  METHODS
  This study includes both retrospective and prospective arms. The data collected included baseline demographic profile, clinical severity on admission to the hospital by the Hunt and Hess grading system and World Federation of Neurological Surgeons (WFNS) grading, radiological severity of bleed by the Fisher's classification, and treatment details. All the patients underwent detailed hormonal evaluation at baseline and 6 months in prospective group while at the end of 1 year in the retrospective group. Hormonal deficiencies between patients with A-com and MCA aneurysmal SAH were compared using appropriate statistical tests.
  
  
  RESULTS
  Of 60 patients studied, 47 patients (A-com: 28 and MCA: 19) were in the retrospective group, while 13 patients (A-com-9, MCA-4) were in the prospective group. The baseline data were comparable between the two groups. At or after 6 months follow-up, 19 (31.6%) patients, 10 patients with A-com and 9 patients with MCA aneurysmal SAH, had some form of hormone deficiency. Furthermore, there was no difference in endocrine dysfunctions between the two groups. There was no correlation between the severity of hormonal deficiency and the clinical severity of SAH grade by Hunt and Hess and radiological grade of SAH by Fisher's grade.
  
  
  CONCLUSIONS
  Hormonal deficiencies are not uncommon in patients with SAH. There is no difference in hormonal deficiencies and severity of hypopituitarism in patients with SAH due to A-com and MCA bleed.
authors.affiliation: Department of Neurosurgery, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
authors.forename: Pinaki
authors.initials: P
authors.lastname: Dutta
authors.forename: Kanchan K
authors.initials: KK
authors.lastname: Mukherjee
authors.forename: Prashant K
authors.initials: PK
authors.lastname: Chaudhary
authors.forename: Shriq Rashid
authors.initials: SR
authors.lastname: Masoodi
authors.forename: Srinivasan
authors.initials: S
authors.lastname: Anand
authors.forename: Ashis
authors.initials: A
authors.lastname: Pathak
authors.forename: Viral N
authors.initials: VN
authors.lastname: Shah
authors.forename: Suresh Narain
authors.initials: SN
authors.lastname: Mathuriya
mesh_terms: D001158:Arteries; D006801:Humans; D002532:Intracranial Aneurysm / Q000601:surgery; D011446:Prospective Studies; D012189:Retrospective Studies; D013345:Subarachnoid Hemorrhage / Q000601:surgery; D017741:Survivors