title: The many roles of the conserved eukaryotic Paf1 complex in regulating transcription, histone modifications, and disease states.
abstract: The Paf1 complex was originally identified over fifteen years ago in budding yeast through its physical association with RNA polymerase II. The Paf1 complex is now known to be conserved throughout eukaryotes and is well studied for promoting RNA polymerase II transcription elongation and transcription-coupled histone modifications. Through these critical regulatory functions, the Paf1 complex participates in numerous cellular processes such as gene expression and silencing, RNA maturation, DNA repair, cell cycle progression and prevention of disease states in higher eukaryotes. In this review, we describe the historic and current research involving the eukaryotic Paf1 complex to explain the cellular roles that underlie its conservation and functional importance. This article is part of a Special Issue entitled: RNA polymerase II Transcript Elongation.
authors.affiliation: Department of Biological Sciences, University of Pittsburgh, Pittsburgh, PA 15260, USA.
authors.forename: Brett N
authors.initials: BN
authors.lastname: Tomson
authors.forename: Karen M
authors.initials: KM
authors.lastname: Arndt
mesh_terms: D000818:Animals; D017124:Conserved Sequence; D004194:Disease / Q000235:genetics*; D056890:Eukaryota / Q000235:genetics*; D006657:Histones / Q000378:metabolism*; D006801:Humans; D008954:Models, Biological; D009687:Nuclear Proteins / Q000737:chemistry / Q000235:genetics / Q000378:metabolism / Q000502:physiology*; D046188:Protein Modification, Translational / Q000235:genetics / Q000502:physiology; D021122:Protein Subunits / Q000737:chemistry / Q000235:genetics / Q000378:metabolism / Q000502:physiology; D014157:Transcription Factors; D014158:Transcription, Genetic / Q000235:genetics* / Q000502:physiology
chemical_list: D006657:Histones; D009687:Nuclear Proteins; C501972:PAF1 protein, human; D021122:Protein Subunits; D014157:Transcription Factors