title: The characteristics, functions and inhibitors of three aminopeptidases belonging to the m1 family.
abstract: Various aminopeptidases belong to the M1 aminopeptidase family. They are all zinc dependent enzymes playing important roles in several biological processes such as regulation of blood pressure under both physiological and pathological conditions, and the angiogenesis and metastasis of tumor, etc. They all have the highly conserved HEXXH(X)18E zinc-binding and GAMEN motifs essential for enzyme activities. In this review, the current situation regarding the biochemical characteristics, biological functions and inhibitors of three important members of these enzymes, aminopeptidase A, aminopeptidase N and aminopeptidase B are summarized.
authors.affiliation: Institute of Medicinal Chemistry, School of Pharmaceutical Sciences, Shandong University, Ji'nan, Shandong province, P.R. China. sunnyboyluan@yahoo.com.cn
authors.forename: Yepeng
authors.initials: Y
authors.lastname: Luan
authors.forename: Chunhua
authors.initials: C
authors.lastname: Ma
authors.forename: Yan
authors.initials: Y
authors.lastname: Wang
authors.forename: Hao
authors.initials: H
authors.lastname: Fang
authors.forename: Wenfang
authors.initials: W
authors.lastname: Xu
mesh_terms: D020816:Amino Acid Motifs; D000626:Aminopeptidases / Q000037:antagonists & inhibitors / Q000737:chemistry / Q000378:metabolism*; D000818:Animals; D018826:CD13 Antigens / Q000037:antagonists & inhibitors / Q000737:chemistry / Q000378:metabolism*; D004791:Enzyme Inhibitors / Q000737:chemistry* / Q000494:pharmacology*; D043384:Glutamyl Aminopeptidase / Q000037:antagonists & inhibitors / Q000737:chemistry / Q000378:metabolism*; D006801:Humans; D006973:Hypertension / Q000188:drug therapy / Q000201:enzymology; D008958:Models, Molecular; D009369:Neoplasms / Q000188:drug therapy / Q000201:enzymology; D012084:Renin-Angiotensin System / Q000187:drug effects
chemical_list: D004791:Enzyme Inhibitors; D000626:Aminopeptidases; D018826:CD13 Antigens; C019721:aminopeptidase B; D043384:Glutamyl Aminopeptidase