title: Amorphous nanosilica particles induce ROS generation in Langerhans cells.
abstract: Generation of total intracellular reactive oxygen species (ROS) was measured in XS52 cells, a Langerhans cell-like line, treated with different sized amorphous silica particles. The results suggested that exposure to amorphous nanosilica particles (nSPs) with a particle size of 70 nm induced a higher level of ROS generation than did exposure to micron-sized amorphous silica particles. This finding means that it is essential to examine the biological effects of ROS generated after exposure to nSPs, which will provide useful information for hazard identification as well as the design of safer nanomaterials.
authors.affiliation: Laboratory of Toxicology and Safety Science, Graduate School of Pharmaceutical Sciences, Osaka University, Osaka, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Yoshida
authors.forename: T
authors.initials: T
authors.lastname: Yoshikawa
authors.forename: H
authors.initials: H
authors.lastname: Nabeshi
authors.forename: K
authors.initials: K
authors.lastname: Matsuyama
authors.forename: T
authors.initials: T
authors.lastname: Hirai
authors.forename: T
authors.initials: T
authors.lastname: Akase
authors.forename: Y
authors.initials: Y
authors.lastname: Yoshioka
authors.forename: N
authors.initials: N
authors.lastname: Itoh
authors.forename: Y
authors.initials: Y
authors.lastname: Tsutsumi
mesh_terms: D002460:Cell Line; D006801:Humans; D007801:Langerhans Cells / Q000187:drug effects / Q000378:metabolism*; D053758:Nanoparticles / Q000633:toxicity*; D010316:Particle Size; D017382:Reactive Oxygen Species / Q000378:metabolism*; D012822:Silicon Dioxide / Q000633:toxicity*
chemical_list: D017382:Reactive Oxygen Species; D012822:Silicon Dioxide