title: RON is not a prognostic marker for resectable pancreatic cancer.
abstract: BACKGROUND
  The receptor tyrosine kinase RON exhibits increased expression during pancreatic cancer progression and promotes migration, invasion and gemcitabine resistance of pancreatic cancer cells in experimental models. However, the prognostic significance of RON expression in pancreatic cancer is unknown.
  
  
  METHODS
  RON expression was characterized in several large cohorts, including a prospective study, totaling 492 pancreatic cancer patients and relationships with patient outcome and clinico-pathologic variables were assessed.
  
  
  RESULTS
  RON expression was associated with outcome in a training set, but this was not recapitulated in the validation set, nor was there any association with therapeutic responsiveness in the validation set or the prospective study.
  
  
  CONCLUSIONS
  Although RON is implicated in pancreatic cancer progression in experimental models, and may constitute a therapeutic target, RON expression is not associated with prognosis or therapeutic responsiveness in resected pancreatic cancer.
authors.affiliation: Cancer Research Program, Garvan Institute of Medical Research, 384 Victoria St, Darlinghurst, Sydney, NSW 2010, Australia.
authors.forename: Carole M
authors.initials: CM
authors.lastname: Tactacan
authors.forename: David K
authors.initials: DK
authors.lastname: Chang
authors.forename: Mark J
authors.initials: MJ
authors.lastname: Cowley
authors.forename: Emily S
authors.initials: ES
authors.lastname: Humphrey
authors.forename: Jianmin
authors.initials: J
authors.lastname: Wu
authors.forename: Anthony J
authors.initials: AJ
authors.lastname: Gill
authors.forename: Angela
authors.initials: A
authors.lastname: Chou
authors.forename: Katia
authors.initials: K
authors.lastname: Nones
authors.forename: Sean M
authors.initials: SM
authors.lastname: Grimmond
authors.forename: Robert L
authors.initials: RL
authors.lastname: Sutherland
authors.forename: Andrew V
authors.initials: AV
authors.lastname: Biankin
authors.forename: Roger J
authors.initials: RJ
authors.lastname: Daly
mesh_terms: D000230:Adenocarcinoma / Q000378:metabolism* / Q000401:mortality / Q000601:surgery; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000032:analysis*; D015153:Blotting, Western; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D053208:Kaplan-Meier Estimate; D008297:Male; D008875:Middle Aged; D010190:Pancreatic Neoplasms / Q000378:metabolism* / Q000401:mortality / Q000601:surgery; D011379:Prognosis; D016016:Proportional Hazards Models; D020794:Receptor Protein-Tyrosine Kinases / Q000032:analysis / Q000096:biosynthesis*; D046888:Tissue Array Analysis
chemical_list: D014408:Biomarkers, Tumor; C080835:RON protein; D020794:Receptor Protein-Tyrosine Kinases