title: Evidence for global reduction in brain cyclic adenosine monophosphate signaling in depression.
authors.affiliation: Department of Behavioral Medicine and Psychiatry, School of Medicine, West Virginia University, Morgantown, West Virginia 25606, USA. jodonnell@hsc.wvu.edu
authors.forename: James M
authors.initials: JM
authors.lastname: O'Donnell
authors.forename: Ying
authors.initials: Y
authors.lastname: Xu
mesh_terms: D000818:Animals; D001921:Brain / Q000000981:diagnostic imaging*; D054703:Cyclic Nucleotide Phosphodiesterases, Type 4 / Q000378:metabolism*; D003865:Major Depressive Disorder / Q000000981:diagnostic imaging*; D015536:Down-Regulation / Q000187:drug effects*; D005260:Female; D006801:Humans; D008297:Male; D058988:Phosphodiesterase 4 Inhibitors / Q000493:pharmacokinetics*; D011877:Radionuclide Imaging; D020889:Rolipram / Q000493:pharmacokinetics*
chemical_list: D058988:Phosphodiesterase 4 Inhibitors; D054703:Cyclic Nucleotide Phosphodiesterases, Type 4; D020889:Rolipram