title: The filling of powdered herbs into two-piece hard capsules using hydrogenated cotton seed oil as lubricant.
abstract: The aim of this work was to investigate the plug formation and filling properties of powdered herbal leaves using hydrogenated cotton seed oil as an alternative lubricant. In a first step, unlubricated and lubricated herbal powders were studied on a small scale using a plug simulator, and low-force compression physics and parameterization techniques were used to narrow down the range in which the optimum amount of lubricant required would be found. In a second step these results were complemented with investigations into the flow properties of the powders based on packing (tapping) experiments to establish the final optimum lubricant concentration. Finally, capsule filling of the optimum formulations was undertaken using an instrumented tamp filling machine. This work has shown that hydrogenated cotton seed oil can be used advantageously for the lubrication of herbal leaf powders. Stickiness as observed with magnesium stearate did not occur, and the optimum lubricant concentration was found to be less than that required for magnesium stearate. In this work, lubricant concentrations of 1% or less hydrogenated cotton seed oil were required to fill herbal powders into capsules on the instrumented tamp-filling machine. It was found that in principle all powders could be filled successfully, but that for some powders the use of higher compression settings was disadvantageous. Relationships between the particle size distributions of the powders, their flow and consolidation as well as their filling properties could be identified by multivariate statistical analysis. The work has demonstrated that a combination of the identification of plug formation and powder flow properties is helpful in establishing the optimum lubricant concentration required using a small quantity of powder and a powder plug simulator. On an automated tamp-filling machine, these optimum formulations produced satisfactory capsules in terms of coefficient of fill weight variability and capsule weight.
authors.affiliation: School of Pharmacy, University of London, UK.
authors.forename: Joanna
authors.initials: J
authors.lastname: Aling
authors.forename: Fridrun
authors.initials: F
authors.lastname: Podczeck
mesh_terms: D002214:Capsules / Q000737:chemistry*; D002626:Chemistry, Pharmaceutical / Q000379:methods; D003369:Cottonseed Oil / Q000737:chemistry*; D029001:Herbal Medicine / Q000379:methods; D054327:Lubricants / Q000737:chemistry*; D008153:Lubrication / Q000379:methods; D010316:Particle Size; D018515:Plant Leaves / Q000737:chemistry; D011208:Powders / Q000737:chemistry*; D012639:Seeds / Q000737:chemistry; D013229:Stearic Acids / Q000737:chemistry; D013678:Technology, Pharmaceutical / Q000379:methods
chemical_list: D002214:Capsules; D003369:Cottonseed Oil; D054327:Lubricants; D011208:Powders; D013229:Stearic Acids; C031183:stearic acid