title: Chemistry on Boranils: an entry to functionalized fluorescent dyes.
abstract: A Boranil fluorophore bearing a nitro-phenyl group has been selectively reduced to its anilino form and then successfully converted to amide, imine, urea, and thiourea derivatives which are fluorescent dyes. Its isolated isothiocyanate intermediate derivative was used in a model labeling experiment with Bovine Serum Albumin (BSA). The purified labeled-BSA exhibits strong luminescence (Φ(f) = 47%) in a phosphate buffer at pH = 7.4.
authors.affiliation: Laboratoire de Chimie Organique et Spectroscopies Avancées (LCOSA),UMR 7515 au CNRS, Ecole de Chimie, Polymères, Matériaux de Strasbourg (ECPM), 25 rue Becquerel, 67087 Strasbourg, Cedex 02, France.
authors.forename: Denis
authors.initials: D
authors.lastname: Frath
authors.forename: Sébastien
authors.initials: S
authors.lastname: Azizi
authors.forename: Gilles
authors.initials: G
authors.lastname: Ulrich
authors.forename: Raymond
authors.initials: R
authors.lastname: Ziessel
mesh_terms: D001896:Boron Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D005456:Fluorescent Dyes / Q000138:chemical synthesis* / Q000737:chemistry; D006863:Hydrogen-Ion Concentration; D017879:Isothiocyanates; D015394:Molecular Structure; D012710:Serum Albumin, Bovine / Q000737:chemistry; D013890:Thiourea / Q000737:chemistry; D014508:Urea / Q000737:chemistry
chemical_list: D001896:Boron Compounds; D005456:Fluorescent Dyes; D017879:Isothiocyanates; D012710:Serum Albumin, Bovine; C037152:isothiocyanic acid; D014508:Urea; D013890:Thiourea