title: Light-regulated host-guest interaction as a new strategy for intracellular PEG-detachable polyplexes to facilitate nuclear entry.
abstract: PEG-detachable polyplexes were constructed for the first time via host-guest interactions between β-cyclodextrin and azobenzene. The polyplexes had excellent colloidal stability and competition stability. Moreover, the intracellular light-regulated dePEGylation facilitated DNA release and nuclear entry, thus resulting in efficient transfection.
authors.affiliation: MOE key Laboratory of Macromolecular Synthesis and Functionalization, Department of Polymer Science and Engineering, Zhejiang University, Hangzhou 310027, PR China.
authors.forename: Wenyu
authors.initials: W
authors.lastname: Li
authors.forename: Youxiang
authors.initials: Y
authors.lastname: Wang
authors.forename: Lina
authors.initials: L
authors.lastname: Chen
authors.forename: Zhixiong
authors.initials: Z
authors.lastname: Huang
authors.forename: Qiaoling
authors.initials: Q
authors.lastname: Hu
authors.forename: Jian
authors.initials: J
authors.lastname: Ji
mesh_terms: D001391:Azo Compounds / Q000737:chemistry* / Q000378:metabolism; D004247:DNA / Q000008:administration & dosage* / Q000235:genetics; D004337:Drug Carriers / Q000737:chemistry* / Q000378:metabolism; D057809:HEK293 Cells; D056945:Hep G2 Cells; D006801:Humans; D008027:Light; D011092:Polyethylene Glycols / Q000737:chemistry* / Q000378:metabolism; D014162:Transfection; D047392:beta-Cyclodextrins / Q000737:chemistry* / Q000378:metabolism
chemical_list: D001391:Azo Compounds; D004337:Drug Carriers; D047392:beta-Cyclodextrins; D011092:Polyethylene Glycols; D004247:DNA; C009850:azobenzene; C031215:betadex