title: Equine G3P[3] rotavirus strain E3198 related to simian RRV and feline/canine-like rotaviruses based on complete genome analyses.
abstract: Equine group A rotavirus (RVA) strains are the most important cause of gastroenteritis in equine neonates and foals worldwide, and G3P[12] and G14P[12] are epidemiologically the most important genotypes. The genotype constellation of an unusual Argentinean G3P[3] RVA strain (RVA/Horse-wt/E3198/2008/G3P[3]) detected in fecal samples of a diarrheic foal in 2008 was shown to be G3-P[3]-I3-R3-C3-M3-A9-N3-T3-E3-H6. Each of these genotypes has been found typically in feline and canine RVA strains, and the genotype constellation is reminiscent to those of Cat97-like RVA strains. However, the phylogenetic analyses revealed only a distant relationship between E3198 and known feline, canine and feline/canine-like human RVA strains. Surprisingly, a rather close relationship was found between E3198 and simian RVA strains RVA/Simian-tc/USA/RRV/1975/G3P[3] for at least 5 gene segments. RRV is believed to be a reassortant between a bovine-like RVA strain and a RVA strains distantly related to feline/canine RVA strains. These analyses indicate that E3198 is unlikely to be of equine origin, and most likely represents a RVA interspecies transmitted virus, possibly in combination with one or more reassortments, from a feline, canine or related host species to a horse. Further studies are in progress to evaluate if this strain was a single interspecies transmission event, or if this strain started to circulate in the equine population.
authors.affiliation: Instituto de Virología, CICVyA, INTA Castelar, Buenos Aires, Argentina.
authors.forename: S
authors.initials: S
authors.lastname: Miño
authors.forename: J
authors.initials: J
authors.lastname: Matthijnssens
authors.forename: A
authors.initials: A
authors.lastname: Badaracco
authors.forename: L
authors.initials: L
authors.lastname: Garaicoechea
authors.forename: M
authors.initials: M
authors.lastname: Zeller
authors.forename: E
authors.initials: E
authors.lastname: Heylen
authors.forename: M
authors.initials: M
authors.lastname: Van Ranst
authors.forename: M
authors.initials: M
authors.lastname: Barrandeguy
authors.forename: V
authors.initials: V
authors.lastname: Parreño
mesh_terms: D000818:Animals; D001483:Base Sequence; D002415:Cats; D002417:Cattle; D004285:Dogs; D005243:Feces / Q000821:virology; D005759:Gastroenteritis / Q000662:veterinary / Q000821:virology; D016679:Genome, Viral; D005838:Genotype; D006734:Horse Diseases / Q000821:virology*; D006736:Horses; D006801:Humans; D008969:Molecular Sequence Data; D010802:Phylogeny; D012401:Rotavirus / Q000145:classification* / Q000235:genetics; D012400:Rotavirus Infections / Q000235:genetics / Q000662:veterinary* / Q000821:virology*