title: Non-invasive identification of melanoma with near-infrared and skin impedance spectroscopy.
abstract: OBJECTIVE
  An early diagnosis of cutaneous malignant melanoma is of high importance for good prognosis. An objective, non-invasive instrument could improve the diagnostic accuracy of melanoma and decrease unnecessary biopsies. The aim of this study was to investigate the use of Near-infrared and skin impedance spectroscopy in combination as a tool to distinguish between malignant and benign skin tumours.
  
  
  METHODS
  Near-infrared and skin impedance spectra were collected in vivo on 50 naevi or suspect melanomas prior to excision. Received data were analysed using multivariate techniques and the results were compared to histopathology analyses of the tumours. A total of 12 cutaneous malignant melanomas, 19 dysplastic naevi and 19 benign naevi were included in the study.
  
  
  RESULTS
  The observed sensitivity and specificity of the proposed method were 83% and 95%, respectively, for malignant melanoma.
  
  
  CONCLUSIONS
  The results indicate that the combination of near-infrared and skin impedance spectroscopy is a promising tool for non-invasive diagnosis of suspect cutaneous malignant melanomas.
authors.affiliation: Department of Surgical and Perioperative Sciences, Surgery, Umeå University, SE-901 85, Umeå, Sweden.
authors.forename: Ida
authors.initials: I
authors.lastname: Bodén
authors.forename: Josefina
authors.initials: J
authors.lastname: Nyström
authors.forename: Bertil
authors.initials: B
authors.lastname: Lundskog
authors.forename: Virginia
authors.initials: V
authors.lastname: Zazo
authors.forename: Paul
authors.initials: P
authors.lastname: Geladi
authors.forename: Britta
authors.initials: B
authors.lastname: Lindholm-Sethson
authors.forename: Peter
authors.initials: P
authors.lastname: Naredi
mesh_terms: D003937:Diagnosis, Differential; D058266:Dielectric Spectroscopy / Q000379:methods* / Q000592:standards; D004416:Dysplastic Nevus Syndrome / Q000145:classification / Q000473:pathology*; D042241:Early Diagnosis; D006801:Humans; D008545:Melanoma / Q000145:classification / Q000473:pathology*; D008954:Models, Biological; D009369:Neoplasms / Q000145:classification / Q000473:pathology; D012680:Sensitivity and Specificity; D012878:Skin Neoplasms / Q000145:classification / Q000473:pathology*; D019265:Spectroscopy, Near-Infrared / Q000379:methods* / Q000592:standards