title: Farnesol induces apoptosis-like phenotype in the phytopathogenic fungus Botrytis cinerea.
abstract: This study demonstrates that the isoprenoid farnesol produces a toxic effect on the phytopathogenic fungus Botrytis cinerea in solid and liquid media. In solid media farnesol retarded 72 h the beginning of mycelial growth. Also, it was demonstrated that the toxic effect is due to farnesol triggers apoptosis in B. cinerea because ROS accumulation, DNA fragmentation and phosphatidylserine externalization were detected in farnesol-treated mycelium. Therefore, compounds that increase the intracellular farnesol or induce apoptosis could have a potential application as fungicide against B. cinerea.
authors.affiliation: Facultad de Química y Biología, Universídad de Santiago de Chile, Santiago, Chile. milena.cotoras@usach.cl
authors.forename: Milena
authors.initials: M
authors.lastname: Cotoras
authors.forename: Paulo
authors.initials: P
authors.lastname: Castro
authors.forename: Herman
authors.initials: H
authors.lastname: Vivanco
authors.forename: Ricardo
authors.initials: R
authors.lastname: Melo
authors.forename: Leonora
authors.initials: L
authors.lastname: Mendoza
mesh_terms: D017209:Apoptosis / Q000187:drug effects*; D020171:Botrytis / Q000166:cytology* / Q000187:drug effects* / Q000235:genetics / Q000378:metabolism; D053938:DNA Fragmentation / Q000187:drug effects; D005204:Farnesol / Q000633:toxicity*; D025282:Mycelium / Q000187:drug effects / Q000254:growth & development / Q000378:metabolism; D010935:Plant Diseases / Q000382:microbiology*; D017382:Reactive Oxygen Species / Q000378:metabolism
chemical_list: D017382:Reactive Oxygen Species; D005204:Farnesol