title: Successful treatment of syringotropic CD8+ mycosis fungoides accompanied by hypohidrosis with vorinostat and retinoids.
abstract: We describe a 34-year-old Japanese man with syringotropic CD8+ mycosis fungoides (MF) accompanied by hypohidrosis who was treated with vorinostat and retinoids. Interestingly, immunohistochemical staining for dermcidin revealed a decrease of sweat in the eccrine glands, and a sweat test by the iodine starch method proved hypohidrosis in the MF-affected areas. Six months after treatment with this combination therapy, the patient's advanced MF was under control.
authors.affiliation: Department of Dermatology, Tohoku University Graduate School of Medicine, Sendai, Japan.
authors.forename: Aya
authors.initials: A
authors.lastname: Kakizaki
authors.forename: Taku
authors.initials: T
authors.lastname: Fujimura
authors.forename: Masato
authors.initials: M
authors.lastname: Mizuashi
authors.forename: Akiko
authors.initials: A
authors.lastname: Watabe
authors.forename: Yumi
authors.initials: Y
authors.lastname: Kambayashi
authors.forename: Setsuya
authors.initials: S
authors.lastname: Aiba
mesh_terms: D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D016827:CD8 Antigens / Q000032:analysis; D006801:Humans; D006877:Hydroxamic Acids / Q000008:administration & dosage; D007007:Hypohidrosis / Q000150:complications*; D007150:Immunohistochemistry; D008297:Male; D009182:Mycosis Fungoides / Q000150:complications* / Q000188:drug therapy* / Q000473:pathology; D012176:Retinoids / Q000008:administration & dosage; D012878:Skin Neoplasms / Q000150:complications / Q000188:drug therapy* / Q000473:pathology; D000077337:Vorinostat
chemical_list: D016827:CD8 Antigens; D006877:Hydroxamic Acids; D012176:Retinoids; D000077337:Vorinostat