title: A synthetic pathway for an unsymmetrical N(5)O(2) heptadentate ligand and its heterodinuclear iron(III)zinc(II) complex: a biomimetic model for the purple acid phosphatases.
abstract: One major field of interest in bioinorganic chemistry is the design and synthesis of inorganic compounds with low molecular mass, showing structural, spectroscopic, and reactivity properties that mimic enzymes, such as purple acid phosphatases (PAPs). In this study, the unsymmetrical heptadentate ligand 2-[(4,7-diisopropyl-1,4,7-triazacyclonon-1-yl)methyl]-6-{[(2-hydroxybenzyl)(pyridin-2-ylmethyl)-amino]methyl}-4-methylphenol (H(2)L) and its first mixed-valence complex [Fe(III)Zn(II)(L)(μ-OAc)(2)]ClO(4)(1) were synthesized. Physical and chemical measurements (crystal structure, conductometry, IR and UV/VIS spectroscopy, and electrochemistry) were performed for 1, and these properties are compared with those presented by the kbPAPs active sites. Potentiometric titration studies of 1 have confirmed its acid/base properties that are crucial for the understanding of the phosphodiester and DNA catalytic cleavage in future studies.
authors.affiliation: Departamento de Química, Universidade Federal de Santa Catarina, Florianópolis - SC, Brazil. dqm2frx@joinville.udesc.br
authors.forename: Fernando R
authors.initials: FR
authors.lastname: Xavier
authors.forename: Adailton J
authors.initials: AJ
authors.lastname: Bortoluzzi
authors.forename: Ademir
authors.initials: A
authors.lastname: Neves
mesh_terms: D000135:Acid Phosphatase / Q000737:chemistry*; D032701:Biomimetics; D020134:Catalytic Domain; D056831:Coordination Complexes / Q000138:chemical synthesis* / Q000737:chemistry; D018360:Crystallography, X-Ray; D006023:Glycoproteins / Q000737:chemistry*; D007501:Iron / Q000737:chemistry*; D008958:Models, Molecular; D015032:Zinc / Q000737:chemistry*
chemical_list: D056831:Coordination Complexes; D006023:Glycoproteins; D007501:Iron; C091137:purple acid phosphatase; D000135:Acid Phosphatase; D015032:Zinc