title: Plasma levels and distribution of gene polymorphisms of factor VII in Turkish population.
abstract: Three factor VII (FVII) promoter haplotypes are associated with stratified plasma FVII levels. To our knowledge, this is the first study examining the distribution of FVII gene polymorphism and levels in Turkish population. The study population was classified into 3 groups according to the absence of coronary arterial disease and presence or absence of a history of myocardial infarction. It was found that the levels of FVII coagulant activity (FVIIc) were higher in the event group than that of the other groups. Participants with high FVIIc levels were found to have 2-fold increased risk for myocardial infarction. The alleles at the FVII loci in all cases are similar. In conclusion, our results indicate that FVIIc levels have an important predictive role in cardiovascular events. The distribution of FVII gene polymorphisms in the Turkish population shows significant differences when compared with European populations.
authors.affiliation: 1Department of Cardiology, Bezmialem University, Istanbul, Turkey.
authors.forename: Murat
authors.initials: M
authors.lastname: Turfan
authors.forename: Fatih
authors.initials: F
authors.lastname: Poyraz
authors.forename: Aysegül Öztürk
authors.initials: AÖ
authors.lastname: Kaymak
authors.forename: Mehmet Ali
authors.initials: MA
authors.lastname: Ergun
authors.forename: Yusuf
authors.initials: Y
authors.lastname: Tavil
authors.forename: Turkiz
authors.initials: T
authors.lastname: Gursel
authors.forename: Adnan
authors.initials: A
authors.lastname: Abaci
mesh_terms: D000941:Antigens / Q000097:blood* / Q000235:genetics*; D005167:Factor VII / Q000235:genetics*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic; D015995:Prevalence; D014421:Turkey
chemical_list: D000941:Antigens; C042580:factor VII clotting antigen; D005167:Factor VII