title: Worry about cancer progression and low perceived social support: implications for quality of life among early-stage breast cancer patients.
abstract: BACKGROUND
  Worry about cancer progression and perceived social support can affect cancer survivors' quality of life (QOL).
  
  
  METHODS
  In 480 early-stage breast cancer survivors, we examined how worry about cancer progression and perceived social support 6 months after definitive surgery were associated with QOL (RAND 36-item Health Survey) at 6-, 12-, and 24-month follow-up.
  
  
  RESULTS
  At 6 months post-surgery, higher worry was associated with worse QOL for five of eight subscales. Lower social support was associated with worse QOL for four subscales. The negative effects of worry and limited social support dissipated for four subscales (worry) and two subscales (social support) by 12-month follow-up and for all subscales by 24-month follow-up. Social support at 6 months moderated the relationship between T2 worry and T4 emotional well-being; post hoc tests did not clarify the nature of the interaction.
  
  
  CONCLUSIONS
  Early-stage breast cancer survivors who worry about cancer progression and/or have low social support may experience lower levels of QOL that can take several months to resolve.
authors.affiliation: Division of Public Health Sciences, Department of Surgery, Washington University School of Medicine, St. Louis, MO, USA. waterse@wudosis.wustl.edu
authors.forename: Erika A
authors.initials: EA
authors.lastname: Waters
authors.forename: Ying
authors.initials: Y
authors.lastname: Liu
authors.forename: Mario
authors.initials: M
authors.lastname: Schootman
authors.forename: Donna B
authors.initials: DB
authors.lastname: Jeffe
mesh_terms: D000328:Adult; D001007:Anxiety / Q000523:psychology*; D001943:Breast Neoplasms / Q000175:diagnosis / Q000473:pathology / Q000523:psychology*; D018270:Carcinoma, Ductal, Breast / Q000175:diagnosis / Q000523:psychology*; D016022:Case-Control Studies; D003430:Cross-Sectional Studies; D018450:Disease Progression; D042241:Early Diagnosis; D005260:Female; D006801:Humans; D008137:Longitudinal Studies; D008875:Middle Aged; D009367:Neoplasm Staging; D011788:Quality of Life / Q000523:psychology*; D012944:Social Support; D017741:Survivors / Q000523:psychology*