title: Microcirculation diagnostics and applied studies in circulatory shock - research from the bench to the bedside.
abstract: Macrohemodynamic targets such as mean arterial pressure, cardiac output, and mixed or central venous oxygen saturation have been used to guide treatment of patients presenting circulatory shock. However, it has been shown that despite of improvement of macrocirculatory parameters there is persisting microcirculatory dysfunction. The restoration of microvascular perfusion in order to improve oxygenation, prevent tissue hypoxia, and maintain organ function represents the main aim of hemodynamic resuscitation. Therefore, microcirculatory targets may represent the most important endpoints to optimize therapy of circulatory shock.
authors.affiliation: Department of Anesthesia, Pain Management and Perioperative Medicine, Dalhousie University, Halifax, NS, Canada. chlehmann@me.com
authors.forename: Christian
authors.initials: C
authors.lastname: Lehmann
authors.forename: Vladimir
authors.initials: V
authors.lastname: Cerny
authors.forename: Islam
authors.initials: I
authors.lastname: Abdo
authors.forename: Hartmut
authors.initials: H
authors.lastname: Kern
authors.forename: Michael
authors.initials: M
authors.lastname: Sander
mesh_terms: D000818:Animals; D002302:Cardiac Output / Q000502:physiology; D015687:Cell Hypoxia / Q000502:physiology; D006439:Hemodynamics; D006801:Humans; D008833:Microcirculation / Q000502:physiology; D012769:Shock / Q000175:diagnosis* / Q000473:pathology / Q000503:physiopathology*