title: Progesterone and Cerebral Function during Emotion Processing in Men and Women with Schizophrenia.
abstract: Schizophrenia has been associated with disturbed levels of sex-steroid hormones, including estrogen and testosterone. In the present study we have examined the implication of a less studied hormone progesterone. Forty-three patients with schizophrenia (21 women) and 43 control participants (21 women) underwent functional MRI while viewing emotionally positive, negative, and neutral images. Blood samples were taken prior to the scanning session to evaluate progesterone levels. Simple regression analyses between levels of progesterone and brain activations associated with emotion processing were performed using SPM5. A positive correlation was found between progesterone levels and brain activations during processing of emotionally charged images in both healthy and schizophrenia men, but no significant relationship was revealed in women. These preliminary results indicate that progesterone is significantly associated with brain activations during processing of positive and negative affect in healthy and schizophrenia men, but not in women. Further investigation is warranted.
authors.affiliation: Centre de Recherche Fernand-Séguin, Hôpital Louis-Hippolyte Lafontaine, 7331 Rue Hochelaga, Montréal, QC, Canada H1N 3V2.
authors.forename: Julie
authors.initials: J
authors.lastname: Champagne
authors.forename: Nadia
authors.initials: N
authors.lastname: Lakis
authors.forename: Josiane
authors.initials: J
authors.lastname: Bourque
authors.forename: Emmanuel
authors.initials: E
authors.lastname: Stip
authors.forename: Olivier
authors.initials: O
authors.lastname: Lipp
authors.forename: Adrianna
authors.initials: A
authors.lastname: Mendrek