title: Anterior segment optical coherence tomography in congenital corneal opacities.
abstract: OBJECTIVE
  To evaluate the clinical usefulness of anterior segment (AS) optical coherence tomography (OCT) in diagnosis and follow-up of children with congenital corneal opacities.
  
  
  METHODS
  Noncomparative case series.
  
  
  METHODS
  Seven consecutive patients with bilateral congenital corneal opacity between 2 days and 2.5 years of age.
  
  
  METHODS
  In addition to basic outpatient examination, eyes were imaged using AS OCT. Anterior segment structures and corneal thicknesses were evaluated from the images. Three children also underwent evaluation under anesthesia, including measurement of corneal thickness with ultrasound pachymetry.
  
  
  METHODS
  Evaluation of the type and severity of the congenital corneal opacity based on the findings in AS OCT.
  
  
  RESULTS
  Thirteen of the 14 eyes could be imaged using AS OCT. The youngest patient studied was only 2 days old. Three distinct phenotypes were found based on the AS OCT findings. Three patients with iridocorneal adhesions were deduced to have type 1 Peters' anomaly, and 2 patients with lenticulocorneal adhesions were deduced to have type 2 Peters' anomaly. The 2 youngest patients had complete corneal opacity with features of corneal staphyloma and marked changes in the AS structures during the first months of life.
  
  
  CONCLUSIONS
  Anterior segment OCT was a valuable method in the diagnosis and follow-up of patients with congenital corneal opacities. As a fast and noncontact technique, it was applicable even for neonates. It allowed early characterization of the type and the extent of the AS disorder.
  
  
  BACKGROUND
  The author(s) have no proprietary or commercial interest in any materials discussed in this article.
authors.affiliation: Helsinki University Eye Hospital, Helsinki, Finland. anna.majander@hus.fi
authors.forename: Anna S
authors.initials: AS
authors.lastname: Majander
authors.forename: Päivi M
authors.initials: PM
authors.lastname: Lindahl
authors.forename: L Kristiina
authors.initials: LK
authors.lastname: Vasara
authors.forename: Kari
authors.initials: K
authors.lastname: Krootila
mesh_terms: D002675:Child, Preschool; D003315:Cornea / Q000002:abnormalities / Q000473:pathology*; D003318:Corneal Opacity / Q000145:classification / Q000151:congenital* / Q000175:diagnosis*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007429:Intraocular Pressure / Q000502:physiology; D008297:Male; D033401:Microscopy, Acoustic; D009887:Ophthalmoscopy; D041623:Tomography, Optical Coherence; D014065:Tonometry, Ocular