title: Subversion of cell signaling by pathogens.
abstract: Pathogens exploit several eukaryotic signaling pathways during an infection. They have evolved specific effectors and toxins to hijack host cell machinery for their own benefit. Signaling molecules are preferentially targeted by pathogens because they globally regulate many cellular processes. Both viruses and bacteria manipulate and control pathways that regulate host cell survival and shape, including MAPK signaling, G-protein signaling, signals controlling cytoskeletal dynamics, and innate immune responses.
authors.affiliation: UT Southwestern Medical Center, Dallas, Texas 75390, USA.
authors.forename: Neal M
authors.initials: NM
authors.lastname: Alto
authors.forename: Kim
authors.initials: K
authors.lastname: Orth
mesh_terms: D001426:Bacterial Proteins / Q000378:metabolism / Q000502:physiology*; D003599:Cytoskeleton / Q000378:metabolism; D019204:GTP-Binding Proteins / Q000378:metabolism / Q000502:physiology; D054884:Host-Pathogen Interactions; D007113:Immunity, Innate; D050356:Lipid Metabolism; D020935:MAP Kinase Signaling System / Q000502:physiology*; D008954:Models, Biological; D009856:Oncogene Proteins, Viral / Q000378:metabolism / Q000502:physiology; D025801:Ubiquitin / Q000378:metabolism; D014764:Viral Proteins / Q000378:metabolism / Q000502:physiology*
chemical_list: D001426:Bacterial Proteins; D009856:Oncogene Proteins, Viral; D025801:Ubiquitin; D014764:Viral Proteins; D019204:GTP-Binding Proteins