title: The nexus of Aβ, aging, and sleep.
abstract: Roh et al. report a positive feedback loop between sleep-wake irregularities and aggregation of β-amyloid peptide, suggesting that sleep alterations could be an early event in Alzheimer's disease.
authors.affiliation: Center for Sleep and Circadian Neurobiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA. gerstner@upenn.edu
authors.forename: Jason R
authors.initials: JR
authors.lastname: Gerstner
authors.forename: Isaac J
authors.initials: IJ
authors.lastname: Perron
authors.forename: Allan I
authors.initials: AI
authors.lastname: Pack
mesh_terms: D000544:Alzheimer Disease / Q000473:pathology* / Q000503:physiopathology*; D016229:Amyloid beta-Peptides / Q000378:metabolism*; D000818:Animals; D002940:Circadian Rhythm / Q000502:physiology*; D006801:Humans; D012890:Sleep / Q000502:physiology*; D014851:Wakefulness / Q000502:physiology*
chemical_list: D016229:Amyloid beta-Peptides