title: Syntheses, characterization, and antitumor activities of platinum(II) and palladium(II) complexes with sugar-conjugated triazole ligands.
abstract: Four platinum(II) and palladium(II) complexes with sugar-conjugated bipyridine-type triazole ligands, [Pt(II)Cl(2)(AcGlc-pyta)] (3), [Pd(II)Cl(2)(AcGlc-pyta)] (4), [Pt(II)Cl(2)(Glc-pyta)] (5), and [Pd(II)Cl(2)(Glc-pyta)] (6), were prepared and characterized by mass spectrometry, elemental analysis, (1)H- and (13)C-NMR, IR as well as UV/VIS spectroscopy, where AcGlc-pyta and Glc-pyta denote 2-[4-(pyridin-2-yl)-1H-1,2,3-triazol-1-yl]ethyl 2,3,4,6-tetra-O-acetyl-β-D-glucopyranoside (1) and 2-[4-(pyridin-2-yl)-1H-1,2,3-triazol-1-yl]ethyl β-D-glucopyranoside (2), respectively. The solid-state structure of complex 6 was determined by single-crystal X-ray-diffraction analysis. These complexes exhibited in vitro cytotoxicity against human cervix tumor cells (HeLa) though weaker than that of cisplatin.
authors.affiliation: Graduate School of Material Science, Nara Institute of Science and Technology, 8916-5, Takayama-cho, Ikoma, Nara 630-0192, Japan. yano-shigenobu@ms.naist.jp
authors.forename: Shigenobu
authors.initials: S
authors.lastname: Yano
authors.forename: Hiromi
authors.initials: H
authors.lastname: Ohi
authors.forename: Mizue
authors.initials: M
authors.lastname: Ashizaki
authors.forename: Makoto
authors.initials: M
authors.lastname: Obata
authors.forename: Yuji
authors.initials: Y
authors.lastname: Mikata
authors.forename: Rika
authors.initials: R
authors.lastname: Tanaka
authors.forename: Takanori
authors.initials: T
authors.lastname: Nishioka
authors.forename: Isamu
authors.initials: I
authors.lastname: Kinoshita
authors.forename: Yuko
authors.initials: Y
authors.lastname: Sugai
authors.forename: Ichiro
authors.initials: I
authors.lastname: Okura
authors.forename: Shun-ichiro
authors.initials: S
authors.lastname: Ogura
authors.forename: Justyna A
authors.initials: JA
authors.lastname: Czaplewska
authors.forename: Michael
authors.initials: M
authors.lastname: Gottschaldt
authors.forename: Ulrich S
authors.initials: US
authors.lastname: Schubert
authors.forename: Takuzo
authors.initials: T
authors.lastname: Funabiki
authors.forename: Keiko
authors.initials: K
authors.lastname: Morimoto
authors.forename: Misaki
authors.initials: M
authors.lastname: Nakai
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000627:therapeutic use; D002241:Carbohydrates / Q000737:chemistry; D002945:Cisplatin / Q000737:chemistry / Q000627:therapeutic use; D056831:Coordination Complexes / Q000138:chemical synthesis* / Q000737:chemistry / Q000627:therapeutic use; D018360:Crystallography, X-Ray; D006367:HeLa Cells; D006801:Humans; D008024:Ligands; D009682:Magnetic Resonance Spectroscopy; D008958:Models, Molecular; D009369:Neoplasms / Q000188:drug therapy; D010165:Palladium / Q000737:chemistry*; D010984:Platinum / Q000737:chemistry*; D014230:Triazoles / Q000138:chemical synthesis* / Q000737:chemistry / Q000627:therapeutic use
chemical_list: D000970:Antineoplastic Agents; D002241:Carbohydrates; D056831:Coordination Complexes; D008024:Ligands; D014230:Triazoles; D010984:Platinum; D010165:Palladium; D002945:Cisplatin