title: Effects of dexamethasone on the development of neonatal rats and level of active caspase-3 in brain cortex.
abstract: Dexamethasone increased the levels of active caspase-3 form in the brain cortex of neonatal rats 120 h after drug administration, but did not affect the expression of this key apoptotic protease in the brain 6 or 24 h postinjection. Increased expression of the active form of caspase-3 in the cerebral cortex was associated with earlier eye opening and delayed formation of startle-reflex in rats.
authors.affiliation: Laboratory of Functional Neurogenomics, Institute of Cytology and Genetics, Siberian Division of Russian Academy of Sciences, Novosibirsk, Russia. eternity@bionet.nsc.ru
authors.forename: P N
authors.initials: PN
authors.lastname: Menshanov
authors.forename: V V
authors.initials: VV
authors.lastname: Muzyka
authors.forename: N N
authors.initials: NN
authors.lastname: Dygalo
mesh_terms: D000704:Analysis of Variance; D000818:Animals; D000831:Animals, Newborn / Q000254:growth & development*; D053148:Caspase 3 / Q000378:metabolism*; D002540:Cerebral Cortex / Q000378:metabolism*; D003720:Densitometry; D003907:Dexamethasone / Q000494:pharmacology*; D005938:Glucocorticoids / Q000494:pharmacology*; D048788:Growth and Development / Q000187:drug effects*; D051381:Rats; D017208:Rats, Wistar; D013216:Reflex, Startle / Q000187:drug effects; D013997:Time Factors
chemical_list: D005938:Glucocorticoids; D003907:Dexamethasone; D053148:Caspase 3