title: Facilitation of neurotransmitter release in mouse motor synapses in different modes of protein kinase C activation.
abstract: Protein kinase C blocker chelerythrine prevented the increase in quantal content of single and rhythmic evoked end-plate potentials after disinhibition of L-type Ca(2+)-channels with paxillin. Phorbol ester increased quantal content of single end-plate potentials and changed rhythmic activity of mouse motor synapses. The effects of phorbol ester were to a great extent neutralized by L-type Ca(2+)-channel blocker nitrendipine and were completely abolished by K(+)-channel blocker 4-aminopyridine. Thus, we discovered different facilitations of transmission after protein kinase C activation with calcium current through L-type channels and with phorbol ester.
authors.affiliation: Department of Human and Animal Physiology, Biological Faculty, M. V. Lomonosov Moscow State University, Russia. gaydukov@gmail.com
authors.forename: A E
authors.initials: AE
authors.lastname: Gaydukov
authors.forename: A A
authors.initials: AA
authors.lastname: Marchenkova
authors.forename: O P
authors.initials: OP
authors.lastname: Balezina
mesh_terms: D015761:4-Aminopyridine; D000818:Animals; D053119:Benzophenanthridines / Q000494:pharmacology; D002121:Calcium Channel Blockers; D020746:Calcium Channels, L-Type / Q000378:metabolism; D004789:Enzyme Activation / Q000502:physiology; D019706:Excitatory Postsynaptic Potentials / Q000187:drug effects; D051379:Mice; D009046:Motor Neurons / Q000378:metabolism*; D018377:Neurotransmitter Agents / Q000378:metabolism*; D009568:Nitrendipine; D051419:Paxillin; D010703:Phorbol Esters / Q000378:metabolism; D011493:Protein Kinase C / Q000378:metabolism*; D018709:Statistics, Nonparametric; D013569:Synapses / Q000378:metabolism*
chemical_list: D053119:Benzophenanthridines; D002121:Calcium Channel Blockers; D020746:Calcium Channels, L-Type; D018377:Neurotransmitter Agents; D051419:Paxillin; D010703:Phorbol Esters; D009568:Nitrendipine; D015761:4-Aminopyridine; C016299:chelerythrine; D011493:Protein Kinase C