title: Phototherapy for pityriasis lichenoides: our experience.
abstract: Pityriasis lichenoides is a benign disease that includes a continuous spectrum with two polar ends: pityriasis lichenoides et varioliformis acuta (PLEVA) and pityriasis lichenoides chronica (PLC). Although its benign and self-limited character, treatment is required, both for itch relief and for cosmetic issues. The present study is a retrospective analysis of 13 patients (11 PLC and 2 PLEVA) treated in our institution with psoralen plus ultraviolet A (PUVA) or ultraviolet A combined with ultraviolet B (UVA/UVB) during the period 1998-2011. In the PUVA group, complete response was achieved in five patients and partial response in two. Total cumulative UVA dose was 84.4 J/cm(2). One patient quit therapy without therapeutic response. In the UVA/UVB group, complete response was achieved in two patients and partial response in an equal number of patients. One patient did not reach a significant improvement. Total cumulative doses were: 26.1 J/cm(2) for UVA and 3.62 J/cm(2) for UVB. There were no acute side effects in either therapeutic group. In the present study, PUVA phototherapy was preferred for patients with more widespread or long-evolving disease, while UVA/UVB was selected for patients who presented more recent disease or contraindications for PUVA therapy. Regardless of the absence of clinical guidelines, both therapeutic options proved to be successful, ascertaining phototherapy as an effective and safe option for pityriasis lichenoides patients.
authors.affiliation: Hospital de Curry Cabral, Dermatology and Venereology Department, Lisbon, Portugal. vmcmacias@gmail.com
authors.forename: Vasco Coelho
authors.initials: VC
authors.lastname: Macias
authors.forename: Gabriela
authors.initials: G
authors.lastname: Marques-Pinto
authors.forename: Jorge
authors.initials: J
authors.lastname: Cardoso
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D005363:Ficusin / Q000627:therapeutic use; D006801:Humans; D008297:Male; D008875:Middle Aged; D017319:Photosensitizing Agents / Q000627:therapeutic use; D017514:Pityriasis Lichenoides / Q000628:therapy*; D016896:Treatment Outcome; D014467:Ultraviolet Therapy; D055815:Young Adult
chemical_list: D017319:Photosensitizing Agents; D005363:Ficusin