title: Association between indicators of disability burden and subsequent depression among older persons.
abstract: BACKGROUND
  Disability is associated with depression in older persons, yet the effect of disability burden on the likelihood of being depressed is uncertain.
  
  
  METHODS
  A total of 754 community-living persons, aged ≥70, underwent monthly assessments in four essential activities of daily living and assessments of depression (yes/no) every 18 months for up to 108 months. Within each 18-month person-interval, participants' disability burden was operationalized as none or any, and according to severity (none, mild, or severe) and chronicity (none, nonchronic, or chronic) given the highest level of severity or chronicity experienced during a given 18-month interval, respectively. A variable combining severity and chronicity (none, nonchronic mild, nonchronic severe, chronic-mild, or chronic-severe) was also created. Using generalized estimating equations, we evaluated the association between each indicator of disability burden and subsequent depression.
  
  
  RESULTS
  Participants who had any versus no disability during the previous 18 months were 65% more likely to experience subsequent depression (OR = 1.65; 95% confidence interval [CI] 1.34, 2.02). Quantifying severity (mild disability vs. none, OR = 1.43; 95% CI: 1.15, 1.79; severe disability vs. none, OR = 2.07; 95% CI 1.56, 2.74) and chronicity (nonchronic disability vs. none, OR = 1.44; 95% CI 1.13, 1.83; chronic disability vs. none, OR = 1.96; 95% CI 1.50, 2.55) indicated increasingly stronger associations with subsequent depression, with the highest likelihood of subsequent depression (OR = 2.42; 95% CI 1.78, 3.30) observed among participants with chronic-severe disability.
  
  
  CONCLUSIONS
  Quantifying the magnitude of disability burden, particularly on the basis of severity and chronicity, provides additional information regarding the likelihood of experiencing subsequent depression among older persons.
authors.affiliation: Center on Aging, University of Connecticut Health Center, 263 Farmington Avenue, Farmington, CT 06030-5215, USA. LiBarry@uchc.edu
authors.forename: Lisa C
authors.initials: LC
authors.lastname: Barry
authors.forename: Pamela R
authors.initials: PR
authors.lastname: Soulos
authors.forename: Terrence E
authors.initials: TE
authors.lastname: Murphy
authors.forename: Stanislav V
authors.initials: SV
authors.lastname: Kasl
authors.forename: Thomas M
authors.initials: TM
authors.lastname: Gill
mesh_terms: D000203:Activities of Daily Living; D000368:Aged; D003237:Connecticut / Q000453:epidemiology; D003863:Depression / Q000453:epidemiology*; D004185:Disability Evaluation; D006233:Persons with Disabilities / Q000706:statistics & numerical data*; D005260:Female; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D015999:Multivariate Analysis; D012720:Severity of Illness Index