title: IgG4-associated tubulointerstitial nephritis: two case reports and a literature review.
abstract: IgG4-related systemic disease (IgG4-RSD) is an autoimmune disease that includes a wide variety of lesions. IgG4-RSD is characterized by high levels of serum IgG4, abundant levels of IgG4-positive plasma cells and T-lymphocyte infiltration in various organs. Tubulointerstitial nephritis (TIN) is a major finding when the kidneys are involved and is effectively treated with corticosteroid therapy. We herein describe two cases of IgG4-related TIN. Such cases have rarely been reported in China.
authors.affiliation: Department of Nephrology, Zhongshan Hospital, Shanghai Fudan University, China.
authors.forename: Yi
authors.initials: Y
authors.lastname: Fang
authors.forename: Jun
authors.initials: J
authors.lastname: Hou
authors.forename: Fengqing
authors.initials: F
authors.lastname: Cai
authors.forename: Xiaoqiang
authors.initials: X
authors.lastname: Ding
authors.forename: Hong
authors.initials: H
authors.lastname: Liu
mesh_terms: D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D000368:Aged; D001327:Autoimmune Diseases / Q000175:diagnosis* / Q000188:drug therapy / Q000276:immunology*; D002465:Cell Movement; D002681:China; D006801:Humans; D007074:Immunoglobulin G / Q000378:metabolism*; D007668:Kidney / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009395:Nephritis, Interstitial / Q000175:diagnosis* / Q000188:drug therapy / Q000276:immunology*; D013601:T-Lymphocytes / Q000473:pathology; D016896:Treatment Outcome
chemical_list: D000305:Adrenal Cortex Hormones; D007074:Immunoglobulin G