title: Sphingolipid signaling in metabolic disorders.
abstract: Sphingolipids, ubiquitous membrane lipids in eukaryotes, carry out a myriad of critical cellular functions. The past two decades have seen significant advances in sphingolipid research, and in 2010 a first sphingolipid receptor modulator was employed as a human therapeutic. Furthermore, cellular signaling mechanisms regulated by sphingolipids are being recognized as critical players in metabolic diseases. This review focuses on recent advances in cellular and physiological mechanisms of sphingolipid regulation and how sphingolipid signaling influences metabolic diseases. Progress in this area may contribute to new understanding and therapeutic options in complex diseases such as atherosclerosis, diabetes, metabolic syndromes, and cancer.
authors.affiliation: Center for Vascular Biology, Department of Pathology and Laboratory Medicine, Weill Cornell Medical College, Cornell University, New York, NY 10065, USA. tih2002@med.cornell.edu
authors.forename: Timothy
authors.initials: T
authors.lastname: Hla
authors.forename: Andrew J
authors.initials: AJ
authors.lastname: Dannenberg
mesh_terms: D050197:Atherosclerosis / Q000378:metabolism / Q000473:pathology; D006801:Humans; D008565:Membrane Proteins / Q000378:metabolism; D008659:Metabolic Diseases / Q000378:metabolism* / Q000473:pathology; D009369:Neoplasms / Q000378:metabolism / Q000473:pathology; D010744:Phosphoric Monoester Hydrolases / Q000378:metabolism; D015398:Signal Transduction; D013107:Sphingolipids / Q000378:metabolism*; D013108:Sphingomyelin Phosphodiesterase / Q000378:metabolism; D013927:Thrombosis / Q000378:metabolism / Q000473:pathology
chemical_list: D008565:Membrane Proteins; D013107:Sphingolipids; C401298:sphingosine-1-phosphate phosphatase; D010744:Phosphoric Monoester Hydrolases; D013108:Sphingomyelin Phosphodiesterase