title: Inflammatory proteins and the severity of dilated Virchow-Robin Spaces in the elderly.
abstract: Recent studies suggest dilated Virchow-Robin Spaces (dVRS) could be a manifestation of cerebral small-vessel disease, but little is known about their risk factors. As inflammation has been associated with other brain MRI findings, we investigated whether interleukin-6 and C-reactive protein were associated with the severity of dVRS in the eldery. dVRS were assessed in basal ganglia and white matter and rated on a severity scale. We found that elevated interleukin-6 levels were associated with higher severity of dVRS in basal ganglia, suggesting that inflammation might be associated with the burden of dVRS in the elderly.
authors.affiliation: INSERM U708 Neuroepidemiology, Bordeaux, France.
authors.forename: Claudia L
authors.initials: CL
authors.lastname: Satizabal
authors.forename: Yi-Cheng
authors.initials: YC
authors.lastname: Zhu
authors.forename: Carole
authors.initials: C
authors.lastname: Dufouil
authors.forename: Christophe
authors.initials: C
authors.lastname: Tzourio
mesh_terms: D000368:Aged; D000375:Aging / Q000473:pathology; D001479:Basal Ganglia / Q000098:blood supply / Q000473:pathology; D001480:Basal Ganglia Diseases / Q000453:epidemiology / Q000276:immunology / Q000473:pathology; D002097:C-Reactive Protein / Q000276:immunology* / Q000378:metabolism; D002560:Cerebrovascular Circulation / Q000276:immunology*; D002561:Cerebrovascular Disorders / Q000453:epidemiology / Q000276:immunology* / Q000473:pathology; D003711:Demyelinating Diseases / Q000453:epidemiology / Q000276:immunology / Q000473:pathology; D004108:Dilatation, Pathologic / Q000453:epidemiology / Q000276:immunology / Q000473:pathology; D004660:Encephalitis / Q000453:epidemiology / Q000276:immunology* / Q000473:pathology; D005260:Female; D006801:Humans; D015850:Interleukin-6 / Q000276:immunology* / Q000378:metabolism; D056784:Leukoencephalopathies / Q000453:epidemiology / Q000276:immunology / Q000473:pathology; D008279:Magnetic Resonance Imaging; D008297:Male; D008833:Microcirculation / Q000276:immunology*; D012307:Risk Factors; D012720:Severity of Illness Index
chemical_list: C508600:IL6 protein, human; D015850:Interleukin-6; D002097:C-Reactive Protein