title: Isolation of a new meroterpene and inhibitors of nitric oxide production from Psoralea corylifolia fruits guided by TLC bioautography.
abstract: A new meroterpene, psoracorylifol F (1), was isolated from Psoralea corylifolia fruits, along with two known meroterpenes (2 and 3), guided by TLC bioautography against O(2)(-) radicals. The structure of 1 was elucidated by means of NMR, HRESIMS, and X-ray crystallographic analysis. All the three metroterpenes possessed potential inhibitory activity against LPS-induced NO production in RAW 264.7 cells with IC(50) values ranging from 7.71 to 27.63μM.
authors.affiliation: Key Laboratory of Standardization of Chinese Medicines of Ministry of Education, The Shanghai Key Laboratory for Compound Chinese Medicines, Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China.
authors.forename: Guodong
authors.initials: G
authors.lastname: Xiao
authors.forename: Xiangkun
authors.initials: X
authors.lastname: Li
authors.forename: Tao
authors.initials: T
authors.lastname: Wu
authors.forename: Zhihong
authors.initials: Z
authors.lastname: Cheng
authors.forename: Qingjiu
authors.initials: Q
authors.lastname: Tang
authors.forename: Tong
authors.initials: T
authors.lastname: Zhang
mesh_terms: D000818:Animals; D002855:Chromatography, Thin Layer / Q000379:methods*; D005638:Fruit / Q000737:chemistry*; D008264:Macrophages / Q000187:drug effects; D051379:Mice; D015394:Molecular Structure; D009569:Nitric Oxide / Q000378:metabolism*; D029907:Psoralea / Q000737:chemistry*; D013729:Terpenes / Q000737:chemistry* / Q000494:pharmacology*
chemical_list: D013729:Terpenes; D009569:Nitric Oxide