title: Cell targeting in anti-cancer gene therapy.
abstract: Gene therapy is a promising approach towards cancer treatment. The main aim of the therapy is to destroy cancer cells, usually by apoptotic mechanisms, and preserving others. However, its application has been hindered by many factors including poor cellular uptake, non-specific cell targeting and undesirable interferences with other genes or gene products. A variety of strategies exist to improve cellular uptake efficiency of gene-based therapies. This paper highlights advancements in gene therapy research and its application in relation to anti-cancer treatment.
authors.affiliation: Institute of Bioscience, Faculty of Veterinary Medicine, Universiti Putra Malaysia, 43400 UPM Serdang, Malaysia.
authors.forename: Mohd Azmi Mohd
authors.initials: MA
authors.lastname: Lila
authors.forename: John Shia Kwong
authors.initials: JS
authors.lastname: Siew
authors.forename: Hayati
authors.initials: H
authors.lastname: Zakaria
authors.forename: Suria Mohd
authors.initials: SM
authors.lastname: Saad
authors.forename: Lim Shen
authors.initials: LS
authors.lastname: Ni
authors.forename: Jafri Malin
authors.initials: JM
authors.lastname: Abdullah