title: The association between obesity and acute myocardial infarction is age- and gender-dependent in a Japanese population.
abstract: Controversies concerning the association between obesity and acute myocardial infarction (AMI) are still ongoing in Japan. We investigated the association between obesity defined by body mass index of 25 kg/m(2) or higher and AMI by a case-control study using data from 1199 AMI cases and 4056 apparently healthy controls. The analysis was performed in age- and sex-matched samples of 621 case-control pairs younger than 80 years and in crude samples aged 40-79 years divided into 10-year age groups. Prevalence of obesity, diabetes, current smoking, hypertension, and hypercholesterolemia were compared between cases and controls, and a multivariable odds ratio (OR) of AMI was calculated for each risk factor in various age groups. The OR (95 % confidence interval (CI)) of AMI for obesity was 1.63 (1.23-2.17), P = 0.0008 in men younger than 80 years; 2.65 (1.41-5.00), P = 0.0025 in women younger than 80 years; 2.23 (1.46-3.41), P = 0.0002 in men aged 59 years or younger; 1.34 (0.90-2.01), P = 0.1510 in men aged 60-79 years; and 2.98 (1.56-5.71), P = 0.0010 in women aged 60-79 years using paired samples. The OR (95 % CI) of AMI for obesity was 4.92 (2.53-9.58), P < 0.0001 in men aged 40-49 years; 1.54 (1.07-2.21), P = 0.0197 in men aged 50-59 years; 1.07 (0.69-1.66), P = 0.7717 in men aged 60-69 years; 2.24 (1.20-4.20), P = 0.0118 in men aged 70-79 years; 2.48 (1.12-5.48), P = 0.0245 in women aged 60-69 years; and 3.05 (1.46-6.37), P = 0.0029 in women aged 70-79 years using crude samples. The association between obesity and AMI was age- and gender-dependent in a Japanese population.
authors.affiliation: Medical Check-up Center, Tachikawa Medical Center, Nagachou 2-2-16, Nagaoka, Niigata, 940-0053, Japan, ijie@venus.sannet.ne.jp.
authors.forename: Eiji
authors.initials: E
authors.lastname: Oda
authors.forename: Masayuki
authors.initials: M
authors.lastname: Goto
authors.forename: Hirooki
authors.initials: H
authors.lastname: Matsushita
authors.forename: Ken
authors.initials: K
authors.lastname: Takarada
authors.forename: Makoto
authors.initials: M
authors.lastname: Tomita
authors.forename: Atsushi
authors.initials: A
authors.lastname: Saito
authors.forename: Koichi
authors.initials: K
authors.lastname: Fuse
authors.forename: Satoru
authors.initials: S
authors.lastname: Fujita
authors.forename: Yoshio
authors.initials: Y
authors.lastname: Ikeda
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Kitazawa
authors.forename: Minoru
authors.initials: M
authors.lastname: Takahashi
authors.forename: Masahito
authors.initials: M
authors.lastname: Sato
authors.forename: Masaaki
authors.initials: M
authors.lastname: Okabe
authors.forename: Yoshifusa
authors.initials: Y
authors.lastname: Aizawa
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D044466:Asian People; D015992:Body Mass Index; D016022:Case-Control Studies; D016009:Chi-Square Distribution; D015897:Comorbidity; D003920:Diabetes Mellitus / Q000208:ethnology; D005260:Female; D006801:Humans; D006937:Hypercholesterolemia / Q000208:ethnology; D006973:Hypertension / Q000208:ethnology; D007564:Japan / Q000453:epidemiology; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D009203:Myocardial Infarction / Q000208:ethnology*; D056128:Obesity, Abdominal / Q000175:diagnosis / Q000208:ethnology*; D016017:Odds Ratio; D015995:Prevalence; D012307:Risk Factors; D012737:Sex Factors; D012907:Smoking / Q000208:ethnology