title: Biochemical indicators of atherogenic and protective activity of xydiphone in experimental animals.
abstract: Atherosclerotic plaque formation and vascular calcinosis were modeled in a subchronic experiment. Reduced HDL and elevated LDL concentrations, increased atherogenic index and albumin toxicity index, and high blood levels of triglycerides and uric acid were early markers of pathology. Xydiphone in combination with vitamin D effectively reduced these changes and the degree of vascular calcinosis.
authors.affiliation: Moscow Research Institute of Pediatrics and Pediatric Surgery, Moscow, Russia. trodina@pedklin.ru
authors.forename: E A
authors.initials: EA
authors.lastname: Yur'eva
authors.forename: V S
authors.initials: VS
authors.lastname: Sukhorukov
authors.forename: A N
authors.initials: AN
authors.lastname: Murashov
authors.forename: M S
authors.initials: MS
authors.lastname: Pimenov
authors.forename: I A
authors.initials: IA
authors.lastname: Ilyushina
authors.forename: A A
authors.initials: AA
authors.lastname: Dreval
mesh_terms: D000469:Alkaline Phosphatase / Q000097:blood; D000818:Animals; D050197:Atherosclerosis / Q000188:drug therapy* / Q000473:pathology; D015415:Biomarkers / Q000378:metabolism*; D008078:Cholesterol, LDL / Q000097:blood; D003402:Creatine Kinase / Q000097:blood; D003404:Creatinine / Q000097:blood; D012968:Etidronic Acid / Q000494:pharmacology / Q000627:therapeutic use*; D007770:L-Lactate Dehydrogenase / Q000097:blood; D015227:Lipid Peroxidation / Q000502:physiology; D008297:Male; D051381:Rats; D012709:Serum Albumin; D014280:Triglycerides / Q000097:blood; D014527:Uric Acid / Q000097:blood; D061205:Vascular Calcification / Q000188:drug therapy* / Q000473:pathology; D014807:Vitamin D / Q000494:pharmacology / Q000627:therapeutic use
chemical_list: D015415:Biomarkers; D008078:Cholesterol, LDL; D012709:Serum Albumin; D014280:Triglycerides; D014807:Vitamin D; D014527:Uric Acid; D003404:Creatinine; D007770:L-Lactate Dehydrogenase; D003402:Creatine Kinase; D000469:Alkaline Phosphatase; D012968:Etidronic Acid