title: Genetic visualization of notch signaling in mammalian neurogenesis.
abstract: Notch signaling plays crucial roles in fate determination and the differentiation of neural stem cells in embryonic and adult brains. It is now clear that the notch pathway is under more complex and dynamic regulation than previously thought. To understand the functional details of notch signaling more precisely, it is important to reveal when, where, and how notch signaling is dynamically communicated between cells, for which the visualization of notch signaling is essential. In this review, we introduce recent technical advances in the visualization of notch signaling during neural development and in the adult brain, and we discuss the physiological significance of dynamic regulation of notch signaling.
authors.affiliation: Institute for Virus Research, Kyoto University, Shogoin-Kawahara, Sakyo-ku, Kyoto, 606-8507, Japan. iimayosh@virus.kyoto-u.ac.jp
authors.forename: Itaru
authors.initials: I
authors.lastname: Imayoshi
authors.forename: Hiromi
authors.initials: H
authors.lastname: Shimojo
authors.forename: Masayuki
authors.initials: M
authors.lastname: Sakamoto
authors.forename: Toshiyuki
authors.initials: T
authors.lastname: Ohtsuka
authors.forename: Ryoichiro
authors.initials: R
authors.lastname: Kageyama
mesh_terms: D000818:Animals; D001921:Brain / Q000196:embryology* / Q000254:growth & development*; D005786:Gene Expression Regulation / Q000235:genetics / Q000502:physiology*; D049452:Green Fluorescent Proteins; D006801:Humans; D008156:Luciferases; D051379:Mice; D008822:Mice, Transgenic; D008954:Models, Biological; D055495:Neurogenesis / Q000235:genetics / Q000502:physiology*; D051880:Receptors, Notch / Q000235:genetics / Q000378:metabolism*; D015398:Signal Transduction / Q000235:genetics / Q000502:physiology*; D001616:beta-Galactosidase
chemical_list: D051880:Receptors, Notch; D049452:Green Fluorescent Proteins; D008156:Luciferases; D001616:beta-Galactosidase