title: Effects of [123I]ADAM, a serotonin transporter radiopharmaceutical, on pregnant Sprague-Dawley rats.
abstract: Serotonin transport abnormalities are implicated in neuropsychiatric disorders. [(123)I]ADAM ([(123)I]-2-([2-({dimethylamino}methyl)phenyl]thio)-5-iodophenylamine) is a novel radiotracer that targets serotonin transporters. We assessed the toxicity of [(123)I]ADAM (18.5 MBq) administered in early- and late-phases (8 and 14 day postfertilization, respectively) of pregnancy. The mortality, clinical status, and gross necropsy were measured in pregnant rats, and the fertility index was measured in rat offspring (weight, clinical observations). We found no dosing-related clinical signs. In conclusion, [(123)I]ADAM was not toxic in an animal pregnancy model.
authors.affiliation: Institute of Nuclear Energy Research, Division of Isotope Application, Taoyuan County, Taiwan.
authors.forename: K W
authors.initials: KW
authors.lastname: Chang
authors.forename: M C
authors.initials: MC
authors.lastname: Lin
authors.forename: S Y
authors.initials: SY
authors.lastname: Lee
authors.forename: H Y
authors.initials: HY
authors.lastname: Chen
authors.forename: C C
authors.initials: CC
authors.lastname: Chen
authors.forename: Y K
authors.initials: YK
authors.lastname: Fu
mesh_terms: D000818:Animals; D002928:Cinanserin / Q000031:analogs & derivatives* / Q000633:toxicity; D005260:Female; D005298:Fertility / Q000187:drug effects / Q000528:radiation effects; D007457:Iodine Radioisotopes; D011247:Pregnancy; D011270:Pregnancy, Animal / Q000528:radiation effects*; D019275:Radiopharmaceuticals / Q000633:toxicity; D051381:Rats; D017207:Rats, Sprague-Dawley; D050486:Serotonin Plasma Membrane Transport Proteins / Q000494:pharmacology / Q000528:radiation effects*
chemical_list: C413491:2-((2-((dimethylamino)methyl)phenyl)thio)-5-iodophenylamine; D007457:Iodine Radioisotopes; D019275:Radiopharmaceuticals; D050486:Serotonin Plasma Membrane Transport Proteins; D002928:Cinanserin