title: Novel tandem column method for the rapid isolation of radiostrontium from human urine.
abstract: A method has been developed for the isolation of strontium from human urine for subsequent determination in sample volumes as low as 5-20 mL. This method involves the acidification of the sample using methanesulfonic acid and its decolorization using charcoal, treatment of the filtrate with Diphonix(®) resin, and subsequent concentration of strontium on Sr resin. Data from retention model simulations provided the initial conditions which were then optimized by actual column separations. Diphonix(®) resin was shown to be effective at removing alkali metal ions from the urine matrix under conditions that retain higher valence ions. The suggested processing method provides 99% recovery of Sr(2+), a concentration factor of 50, and an expected per sample processing time of less than 1 h.
authors.affiliation: Department of Chemistry and Biochemistry, University of Wisconsin - Milwaukee, 3210 N Cramer Street, Milwaukee, WI 53211, USA.
authors.forename: Cory A
authors.initials: CA
authors.lastname: Hawkins
authors.forename: Ilya A
authors.initials: IA
authors.lastname: Shkrob
authors.forename: Carol J
authors.initials: CJ
authors.lastname: Mertz
authors.forename: Mark L
authors.initials: ML
authors.lastname: Dietz
authors.forename: Michael D
authors.initials: MD
authors.lastname: Kaminski
mesh_terms: D053000:Analytic Sample Preparation Methods; D001822:Body Burden; D002852:Chromatography, Ion Exchange / Q000379:methods*; D004781:Environmental Exposure / Q000032:analysis; D006801:Humans; D007475:Ion Exchange Resins / Q000737:chemistry; D012964:Sodium / Q000302:isolation & purification / Q000652:urine; D052616:Solid Phase Extraction / Q000379:methods; D013326:Strontium Radioisotopes / Q000302:isolation & purification* / Q000652:urine*; D014556:Urine / Q000737:chemistry*
chemical_list: D007475:Ion Exchange Resins; D013326:Strontium Radioisotopes; D012964:Sodium