title: The effect of maximum voided volume on response to desmopressin therapy in children with enuresis.
abstract: OBJECTIVE
  This study was aimed to determine the effect of maximum voided volume (MVV) on the efficacy of desmopressin, which is commonly used to treat primary monosymptomatic nocturnal enuresis (PMNE) in children and adolescents.
  
  
  METHODS
  Bladder capacity was measured with different methods in 52 patients with PMNE, and the effect of bladder capacity on desmopressin therapy was investigated.
  
  
  RESULTS
  Patients with PMNE in whom MVV was 70% or less of estimated bladder capacity were found to be unresponsive to desmopressin therapy.
  
  
  CONCLUSIONS
  The MVV can be measured before desmopressin therapy in patients with PMNE as a marker to predict treatment success. Our results suggest that desmopressin should not be used in patients with low MVV.
authors.affiliation: Department of Pediatrics, Duzce University Medical Faculty, Konuralp-Düzce, Turkey. okurmesut@yahoo.com
authors.forename: Mesut
authors.initials: M
authors.lastname: Okur
authors.forename: Semiha Fatma
authors.initials: SF
authors.lastname: Ozen
authors.forename: Kenan
authors.initials: K
authors.lastname: Kocabay
authors.forename: Kamil
authors.initials: K
authors.lastname: Cam
authors.forename: Aybars
authors.initials: A
authors.lastname: Ozkan
authors.forename: Hakan
authors.initials: H
authors.lastname: Uzun
mesh_terms: D000293:Adolescent; D002648:Child; D003894:Deamino Arginine Vasopressin / Q000494:pharmacology* / Q000627:therapeutic use*; D004775:Enuresis / Q000188:drug therapy* / Q000503:physiopathology*; D005260:Female; D006801:Humans; D008297:Male; D016896:Treatment Outcome; D001743:Urinary Bladder / Q000187:drug effects / Q000503:physiopathology; D014554:Urination / Q000187:drug effects*
chemical_list: D003894:Deamino Arginine Vasopressin