title: Interactions between HIV-1 and innate immunity in dendritic cells.
abstract: Dendritic cells couple pathogen sensing with induction of innate and adaptive immune responses. Pathogen sensing in dendritic cells relies on interactions between molecular patterns of the pathogens and germline-encoded, also referred to as innate, receptors. In this chapter, we analyze some of the interactions between HIV-1 and the innate immune system in dendritic cells. The HIV-1 replication cycle is constituted by an extracellular and an intracellular phase. The two phases of the cycle provide distinct opportunities for interactions with cell-extrinsic and cell-intrinsic mechanisms in dendritic cells. According to the types of dendritic cells, the mechanisms of innate interactions between dendritic cells and HIV-1 lead to specific responses. These innate interactions may contribute to influencing and shaping the adaptive immune response against the virus.
authors.affiliation: Department of Immunity and Cancer, Institut Curie-INSERM U932, Paris, France.
authors.forename: Aymeric
authors.initials: A
authors.lastname: Silvin
authors.forename: Nicolas
authors.initials: N
authors.lastname: Manel
mesh_terms: D003713:Dendritic Cells / Q000276:immunology*; D015497:HIV-1 / Q000276:immunology / Q000502:physiology*; D006801:Humans; D007113:Immunity, Innate; D014779:Virus Replication