title: Short term effects of non-surgical periodontal treatment on gingival crevicular fluid levels of tissue plasminogen activator (t-PA) and plasminogen activator inhibitor 2 (PAI-2) in patients with chronic and aggressive periodontitis.
abstract: OBJECTIVE
  The purpose of this study was to evaluate the gingival crevicular fluid (GCF) levels of tissue type plasminogen activator (t-PA) and plasminogen activator inhibitor 2 (PAI-2) in aggressive periodontitis (AgP), chronic periodontitis (CP) and periodontally healthy control subjects, before (BT) and after (AT) the non-surgical periodontal treatment.
  
  
  METHODS
  Systemically healthy 12 CP and 13 AgP patients and 20 control subjects were included in this study. Plaque index, gingival index, probing depth and clinical attachment levels were recorded and GCF samples were collected BT and AT. Assays for GCF t-PA and PAI-2 levels were carried out by an enzyme linked immunosorbent assay (ELISA). The χ(2), Wilcoxon and Mann-Whitney U tests and Spearman correlation coefficient were used for data analyses.
  
  
  RESULTS
  Statistically significant reductions in clinical index scores were noted in both periodontitis groups after treatment. No significant differences were detected in GCF levels of t-PA and PAI-2 between CP and AgP groups at either BT or AT. There was a statistically significant decrease in GCF PAI-2 levels in CP after therapy (p<0.01). GCF t-PA levels in CP and AgP groups exhibited significant correlations with PD and CAL measurements at both BT and AT (p<0.01).
  
  
  CONCLUSIONS
  Significant decrease was detected for GCF PAI-2 levels in CP and clinical parameters in both CP and AgP by non-surgical periodontal treatment.
authors.affiliation: Gazi University, Faculty of Dentistry, Department of Periodontology, Ankara, Turkey. gulay@gazi.edu.tr
authors.forename: Gülay
authors.initials: G
authors.lastname: Tüter
authors.forename: Burcu
authors.initials: B
authors.lastname: Ozdemir
authors.forename: Bülent
authors.initials: B
authors.lastname: Kurtiş
authors.forename: Muhittin
authors.initials: M
authors.lastname: Serdar
authors.forename: Ayşegül Atak
authors.initials: AA
authors.lastname: Yücel
authors.forename: Eylem
authors.initials: E
authors.lastname: Ayhan
mesh_terms: D000328:Adult; D010520:Aggressive Periodontitis / Q000378:metabolism / Q000628:therapy*; D016022:Case-Control Studies; D055113:Chronic Periodontitis / Q000378:metabolism / Q000628:therapy*; D003774:Dental Plaque Index; D012534:Dental Scaling; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D005883:Gingival Crevicular Fluid / Q000378:metabolism*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010512:Periodontal Index; D017396:Plasminogen Activator Inhibitor 2 / Q000378:metabolism*; D016745:Root Planing; D018709:Statistics, Nonparametric; D010959:Tissue Plasminogen Activator / Q000378:metabolism*
chemical_list: D017396:Plasminogen Activator Inhibitor 2; D010959:Tissue Plasminogen Activator