title: Anxiogenic effect of low-dose methamphetamine in the test of elevated plus-maze.
abstract: Methamphetamines (MA) are psychostimulant drugs that are known to           change individuals' behavior. Psychostimulants could either evoke positive emotions           (e.g. joy and happiness) or attenuate negative emotional states (e.g. anxiety and           depression) in humans. In animal experiments, the test of elevated plus-maze (EPM)           is widely used. This test is appropriate for evaluation of anxiolytic and anxiogenic           drug effects, or for examination of specific subtypes of anxiety disorders. The aim of           the present study was to examine the effect of acute single dose of MA (1 mg/kg)           on the behavior of laboratory rat in the EPM. The detailed ethologic analysis of           behavior was performed using a modified protocol based on the study of Fernández           Espejo (1997). Our results demonstrated that MA affects rat's behavior in the EPM           in the majority of analyzed categories. The present protocol allowed us to determine           positive anxiogenic effect of MA.
authors.affiliation: Department of Normal, Pathological and Clinical Physiology, Charles University, Prague, Czech Republic. mpomet@lf3.cuni.cz
authors.forename: M
authors.initials: M
authors.lastname: Pometlová
authors.forename: K
authors.initials: K
authors.lastname: Nohejlová-Deykun
authors.forename: R
authors.initials: R
authors.lastname: Slamberová
mesh_terms: D000818:Animals; D014151:Anti-Anxiety Agents / Q000494:pharmacology*; D001522:Behavior, Animal / Q000187:drug effects*; D008297:Male; D018782:Maze Learning / Q000187:drug effects*; D008694:Methamphetamine / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar
chemical_list: D014151:Anti-Anxiety Agents; D008694:Methamphetamine