title: Molecular signature in HCV-positive lymphomas.
abstract: Hepatitis C virus (HCV) is a positive, single-stranded RNA virus, which has been associated to different subtypes of B-cell non-Hodgkin lymphoma (B-NHL). Cumulative evidence suggests an HCV-related antigen driven process in the B-NHL development. The underlying molecular signature associated to HCV-related B-NHL has to date remained obscure. In this review, we discuss the recent developments in this field with a special mention to different sets of genes whose expression is associated with BCR coupled to Blys signaling which in turn was found to be linked to B-cell maturation stages and NF-κb transcription factor. Even if recent progress on HCV-B-NHL signature has been made, the precise relationship between HCV and lymphoma development and phenotype signature remain to be clarified.
authors.affiliation: Unit of Clinical and Experimental Pharmacology, IRCCS, Centro di Riferimento Oncologico, National Cancer Institute, 33081 Aviano, Pordenone, Italy. vdere@cro.it
authors.forename: Valli
authors.initials: V
authors.lastname: De Re
authors.forename: Laura
authors.initials: L
authors.lastname: Caggiari
authors.forename: Marica
authors.initials: M
authors.lastname: Garziera
authors.forename: Mariangela
authors.initials: M
authors.lastname: De Zorzi
authors.forename: Ombretta
authors.initials: O
authors.lastname: Repetto
mesh_terms: D053264:B-Cell Activating Factor / Q000378:metabolism; D001402:B-Lymphocytes / Q000276:immunology / Q000378:metabolism; D016174:Hepacivirus / Q000235:genetics / Q000276:immunology / Q000502:physiology; D018936:Hepatitis C Antigens; D019698:Hepatitis C, Chronic / Q000276:immunology / Q000378:metabolism / Q000821:virology; D006801:Humans; D016393:Lymphoma, B-Cell / Q000235:genetics* / Q000378:metabolism / Q000821:virology*; D016328:NF-kappa B / Q000378:metabolism; D011947:Receptors, Antigen, B-Cell / Q000276:immunology / Q000378:metabolism; D015398:Signal Transduction
chemical_list: D053264:B-Cell Activating Factor; D018936:Hepatitis C Antigens; D016328:NF-kappa B; D011947:Receptors, Antigen, B-Cell; C505719:TNFSF13B protein, human