title: Intraocular schwannoma.
abstract: Schwannoma is a proliferation of neoplastic Schwann cells. Whereas schwannomas of the head and neck region are common, intraocular tissues are rarely affected. Uveal schwannoma has been aptly called a "pseudomelanoma", reflecting the difficulty in its clinical distinction from uveal malignant melanoma. Most of our current knowledge on intraocular schwannoma is limited to case reports, short case series, and non-comprehensive literature reviews. Three isolated reports of uveal schwannoma with extrascleral extension exist in literature, but the prognostic significance of this growth pattern is unknown. We present a patient with choroidal schwannoma with extrascleral extension and review 46 previously reported cases of uveal schwannomas to delineate clinical and pathologic characteristics of these intraocular tumors with a specific emphasis on schwannoma with extraocular extension.
authors.affiliation: Department of Pathology and Laboratory Medicine, The New York Eye and Ear Infirmary, New York, NY 10003, USA.
authors.forename: Jae Young
authors.initials: JY
authors.lastname: You
authors.forename: Paul T
authors.initials: PT
authors.lastname: Finger
authors.forename: Codrin
authors.initials: C
authors.lastname: Iacob
authors.forename: Steven A
authors.initials: SA
authors.lastname: McCormick
authors.forename: Tatyana
authors.initials: T
authors.lastname: Milman
mesh_terms: D014408:Biomarkers, Tumor / Q000032:analysis; D002830:Choroid Neoplasms / Q000000981:diagnostic imaging / Q000473:pathology*; D015353:Eye Enucleation; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D064847:Multimodal Imaging; D009361:Neoplasm Invasiveness; D009442:Neurilemmoma / Q000000981:diagnostic imaging / Q000473:pathology*; D049268:Positron-Emission Tomography; D015422:Scleral Diseases / Q000000981:diagnostic imaging / Q000473:pathology*; D014057:Tomography, X-Ray Computed; D014463:Ultrasonography; D014792:Visual Acuity / Q000502:physiology; D055815:Young Adult
chemical_list: D014408:Biomarkers, Tumor