title: Impact of cerebrospinal-fluid oligoclonal immunoglobulin bands and HLA-DRB1 risk alleles on brain magnetic-resonance-imaging lesion load in Swedish multiple sclerosis patients.
abstract: Approximately 95% of Nordic multiple sclerosis (MS) patients display oligoclonal immunoglobulin G bands (OCB) in the cerebrospinal fluid. From a cohort of 2094 MS patients we retrieved well-characterized data from 40 OCB-negative and 60 OCB-positive patients, in an effort to determine whether lesion load on brain magnetic resonance imaging is affected by OCB status and carriage of HLA-DRB1*15 or HLA-DRB1*04. Positivity for OCB did not increase the risk of belonging to higher-lesion-load groups; nor did carrying HLA-DRB1*15 or HLA-DRB1*04. A trend was seen, however, whereby OCB positivity conferred a two-fold risk of displaying higher lesion loads infratentorially.
authors.affiliation: MS Research Unit, Department of Clinical Neuroscience, Center for Molecular Medicine, Karolinska Institutet, Stockholm, Sweden. virginija.karrenbauer@ki.se
authors.forename: Virginija Danylaitė
authors.initials: VD
authors.lastname: Karrenbauer
authors.forename: Robert
authors.initials: R
authors.lastname: Prejs
authors.forename: Thomas
authors.initials: T
authors.lastname: Masterman
authors.forename: Jan
authors.initials: J
authors.lastname: Hillert
authors.forename: Anna
authors.initials: A
authors.lastname: Glaser
authors.forename: Kerstin
authors.initials: K
authors.lastname: Imrell
mesh_terms: D000328:Adult; D000483:Alleles; D001921:Brain / Q000473:pathology*; D005260:Female; D005500:Follow-Up Studies; D059811:HLA-DRB1 Chains / Q000235:genetics*; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000134:cerebrospinal fluid / Q000235:genetics / Q000473:pathology; D043025:Oligoclonal Bands / Q000134:cerebrospinal fluid*; D012189:Retrospective Studies; D012307:Risk Factors; D013548:Sweden / Q000453:epidemiology; D055815:Young Adult
chemical_list: D059811:HLA-DRB1 Chains; D043025:Oligoclonal Bands