title: [Effect of salvia miltiorrhiza and Ligustrazine injection on the early myocardial damage of patients with severe burn].
abstract: OBJECTIVE
  To observe the effect of salvia miltiorrhiza and ligustrazine injection on the early myocardial damage of severely burned patients.
  
  
  METHODS
  Twenty severely burned patients hospitalized from January 2010 to August 2011, with burn area equal to or more than 50% TBSA, were divided into two groups following hospitalization sequence, with odd number patients entering treatment group (T, n = 10) and even number patients entering control group (C, n = 10). Patients in C group were treated with routine methods, including fluid resuscitation based on the Third Military Medical University formula, anti-infection treatment, support treatment, and organ-protection treatment, etc. In addition to routine treatment methods, patients in T group received intravenous infusion of 250 mL glucose injection (50 g/L) containing 10 mL salvia miltiorrhiza and ligustrazine concoction, once a day, and continued for three days. Venous blood of patients was drawn at post burn hour (PBH) 12, 24, 48, and 72 to determine the plasma levels of cardiac troponin I (cTnI), creatine kinase isozyme MB (CK-MB), and atrial natriuretic peptide (ANP). Data were processed with t test.
  
  
  RESULTS
  At each time point, levels of cTnI, CK-MB, and ANP were lower in T group than in C group. Differences in contents of these parameters between two groups were statistically significant at most time points, with t values from 2.136 to 2.918, P < 0.05 or P < 0.01. Plasma levels of cTnI, CK-MB, and ANP in both groups peaked at PBH 12, which were respectively (28 ± 10) ng/mL, (76 ± 13) U/L, (430 ± 87) pg/mL in T group, and (38 ± 11) ng/mL, (87 ± 10) U/L, (453 ± 91) pg/mL in C group. From PBH 24 to 72, contents of above-mentioned parameters decreased gradually in both groups.
  
  
  CONCLUSIONS
  Early use of salvia miltiorrhiza and ligustrazine injection in severely burned patients can effectively reduce myocardial damage, thus protect the myocardium from injury.
authors.affiliation: Department of Burns and Plastic Surgery, the Third Affiliated Hospital of Nantong University, Wuxi 214041, China.
authors.forename: Ling-tao
authors.initials: LT
authors.lastname: Ding
authors.forename: Yu-gang
authors.initials: YG
authors.lastname: Zhu
authors.forename: Zai-qiu
authors.initials: ZQ
authors.lastname: Gu
authors.forename: Liang-liang
authors.initials: LL
authors.lastname: Cai
authors.forename: Jing-liang
authors.initials: JL
authors.lastname: Peng
authors.forename: Guo-zhong
authors.initials: GZ
authors.lastname: Lü
mesh_terms: D000293:Adolescent; D000328:Adult; D002056:Burns / Q000097:blood / Q000188:drug therapy*; D052279:Creatine Kinase, MB Form / Q000097:blood; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009206:Myocardium / Q000473:pathology*; D011719:Pyrazines / Q000627:therapeutic use*; D027561:Salvia miltiorrhiza; D019210:Troponin I / Q000097:blood; D055815:Young Adult
chemical_list: D004365:Drugs, Chinese Herbal; D011719:Pyrazines; D019210:Troponin I; D052279:Creatine Kinase, MB Form; C017953:tetramethylpyrazine