title: The effects of perinatal fluoxetine treatment on the circadian system of the adult mouse.
abstract: BACKGROUND
  Depression is prevalent among women of childbearing age and is frequently treated with selective serotonin reuptake inhibitors (SSRIs). As some SSRIs, such as fluoxetine (Flx), can cross the placenta, it is possible that the neurodevelopment of the fetus may be affected, leading to altered behavior in adulthood.
  
  
  OBJECTIVE
  In this study, we examined the effects of perinatal Flx exposure on the subsequent expression of circadian rhythms in adult mice.
  
  
  METHODS
  Dams were treated with 25 mg/kg/day Flx in their drinking water from embryonic day 15 to postnatal day 12. Circadian organization of wheel running rhythms and phase shifts to photic and non-photic stimuli were assessed in the offspring starting at 6 weeks of age.
  
  
  RESULTS
  We found that perinatal Flx exposure led to larger light-induced phase advances (1.19 ± 0.51 vs. 0.55 ± 0.25 h), smaller phase advances to the serotonin agonist 8-OH-DPAT during the mid-subjective day (0.44 ± 0.15 vs. 0.70 ± 0.17 h), and a shorter free-running period in constant darkness (23.47 ± 0.13 vs. 23.64 ± 0.13 h).
  
  
  CONCLUSIONS
  These results suggest that perinatal exposure to SSRIs may have consequences for the functioning of the circadian system later in life.
authors.affiliation: Department of Psychology, University of Calgary, 2500 University Drive NW, Calgary, Alberta, Canada.
authors.forename: Veronika
authors.initials: V
authors.lastname: Kiryanova
authors.forename: Victoria M
authors.initials: VM
authors.lastname: Smith
authors.forename: Richard H
authors.initials: RH
authors.lastname: Dyck
authors.forename: Michael C
authors.initials: MC
authors.lastname: Antle
mesh_terms: D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects; D057906:Circadian Clocks / Q000187:drug effects*; D003624:Darkness; D005260:Female; D005473:Fluoxetine / Q000008:administration & dosage / Q000009:adverse effects*; D005865:Gestational Age; D008027:Light; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D009043:Motor Activity / Q000187:drug effects; D010775:Photic Stimulation; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects / Q000139:chemically induced* / Q000523:psychology; D017367:Selective Serotonin Reuptake Inhibitors / Q000008:administration & dosage / Q000009:adverse effects*
chemical_list: D005473:Fluoxetine; D017367:Selective Serotonin Reuptake Inhibitors