title: [Alcohol intake--a two-edged sword. Part 1: metabolism and pathogenic effects of alcohol].
abstract: From the biomedical point of view alcohol is a Janus-faced dietary component with a dose-dependent effect varying from cardiovascular protection to cytotoxicity. Alcohol is absorbed in the upper gastrointestinal tract by passive diffusion, is quickly distributed throughout body water and is mostly eliminated through oxidation. The enzymatically-catalyzed oxidative degradation to acetaldehyde and further to acetate is primarily localized in the liver. In case of a low blood alcohol concentration (<0.5 per thousand) alcohol is predominantely metabolized by the enzyme aldehyde dehydrogenase; higher blood concentrations (>0.5 per thousand) are increasingly oxidized by the microsomal ethanoloxidizing system (MEOS). Alcohol consumption induces several metabolic reactions as well as acute effects on the central nervous system. Chronic alcohol consumption to some extent irreparably damages nearly every organ with the liver being particularly concerned. There are three stages of alcohol-induced liver disease (fatty liver, alcohol hepatitis, liver cirrhosis) and the liver damages mainly result from reaction products of alcohol degradation (acetaldehyde, NADH and reactive oxygen species). An especially dreaded clinical complication of the alcohol-induced liver disease is the hepatic encephalopathy. Its pathogenesis is a multifactorial and self-perpetuating process with the swelling of astrocytes being a crucial point. Swollen astrocytes induce several reactions such as oxidative/nitrosative stress, impaired signal transduction, protein modifications and a modified gene expression profile. The swelling of astrocytes and the change in neuronal activity are attributed to several neurotoxins, especially ammonia and aromatic amino acids. In alcohol addicted subjects multiple micronutrient deficiencies are common. The status of folic acid, thiamine, pyridoxine and zinc is especially critical.
authors.affiliation: Leibniz Universität Hannover, Institut für Lebensmittelwissenschaft und Humanernährung, Hannover. stroehle@nutrition.uni-hannover.de
authors.forename: Alexander
authors.initials: A
authors.lastname: Ströhle
authors.forename: Maike
authors.initials: M
authors.lastname: Wolters
authors.forename: Andreas
authors.initials: A
authors.lastname: Hahn
mesh_terms: D000428:Alcohol Drinking / Q000009:adverse effects* / Q000378:metabolism; D000444:Aldehyde Dehydrogenase / Q000378:metabolism; D002492:Central Nervous System Depressants / Q000009:adverse effects* / Q000378:metabolism; D004347:Drug Interactions; D000431:Ethanol / Q000009:adverse effects* / Q000378:metabolism; D005234:Fatty Liver / Q000139:chemically induced / Q000473:pathology; D006501:Hepatic Encephalopathy / Q000473:pathology / Q000523:psychology; D006519:Hepatitis, Alcoholic / Q000473:pathology; D006801:Humans; D008103:Liver Cirrhosis / Q000473:pathology; D018384:Oxidative Stress / Q000187:drug effects
chemical_list: D002492:Central Nervous System Depressants; D000431:Ethanol; D000444:Aldehyde Dehydrogenase