title: Concise construction of the tetracyclic core of lycorine-type alkaloids and the formal synthesis of α-lycorane based on asymmetric bifunctional thiourea-catalyzed cascade reaction.
abstract: A concise and stereoselective construction of the tetracyclic core of lycorine-type alkaloids and the formal synthesis of α-lycorane has been achieved. The feature of the current method is the employment of a bifunctional thiourea-catalyzed cascade reaction as a powerful tool to construct the skeleton of the natural product, which is a challenging yet very rarely explored strategy. As a result, the tetracyclic core is efficiently synthesized in just three simple operations involving two consecutive cascade reactions.
authors.affiliation: State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University, PR China.
authors.forename: Yao
authors.initials: Y
authors.lastname: Wang
authors.forename: Yong-Chun
authors.initials: YC
authors.lastname: Luo
authors.forename: Hong-Bo
authors.initials: HB
authors.lastname: Zhang
authors.forename: Peng-Fei
authors.initials: PF
authors.lastname: Xu
mesh_terms: D047151:Amaryllidaceae Alkaloids / Q000138:chemical synthesis* / Q000737:chemistry*; D002384:Catalysis; D018360:Crystallography, X-Ray; D003500:Cyclization; D015394:Molecular Structure; D010617:Phenanthridines / Q000737:chemistry*; D013890:Thiourea / Q000737:chemistry*
chemical_list: D047151:Amaryllidaceae Alkaloids; D010617:Phenanthridines; C412290:lycorane; D013890:Thiourea; C015330:lycorine