title: ISG15 regulates IFN-γ immunity in human mycobacterial disease.
abstract: Interferon-gamma (IFN-γ) is crucial for immunity against different pathogens due to its broad effects on the multiple arms of the immune system. The regulation of IFN-γ immunity is of extensive interest to research as well as practical activity for drug discovery. New evidence supports previous findings that ubiquitin-like protein ISG15 acts as an extracellular cytokine and promotes IFN-γ production, providing intriguing insights of the importance of ISG15 into the control of human mycobacterial disease.
authors.affiliation: Moores Cancer Center, University of California, San Diego, La Jolla, CA 92093, USA.
authors.forename: Jun-Bao
authors.initials: JB
authors.lastname: Fan
authors.forename: Dong-Er
authors.initials: DE
authors.lastname: Zhang
mesh_terms: D000293:Adolescent; D000595:Amino Acid Sequence; D000818:Animals; D001500:BCG Vaccine / Q000276:immunology; D017252:CD3 Complex / Q000378:metabolism; D002648:Child; D016207:Cytokines / Q000235:genetics / Q000378:metabolism*; D005260:Female; D006801:Humans; D007371:Interferon-gamma / Q000378:metabolism*; D007694:Killer Cells, Natural / Q000276:immunology / Q000378:metabolism; D008214:Lymphocytes / Q000276:immunology / Q000378:metabolism; D008297:Male; D051379:Mice; D009164:Mycobacterium Infections / Q000276:immunology / Q000378:metabolism* / Q000517:prevention & control; D014452:Ubiquitins / Q000235:genetics / Q000378:metabolism*; D014611:Vaccination
chemical_list: D001500:BCG Vaccine; D017252:CD3 Complex; D016207:Cytokines; D014452:Ubiquitins; C074034:ISG15 protein, human; D007371:Interferon-gamma