title: Solid-organ transplantation in older adults: current status and future research.
abstract: An increasing number of patients older than 65 years are referred for and have access to organ transplantation, and an increasing number of older adults are donating organs. Although short-term outcomes are similar in older versus younger transplant recipients, older donor or recipient age is associated with inferior long-term outcomes. However, age is often a proxy for other factors that might predict poor outcomes more strongly and better identify patients at risk for adverse events. Approaches to transplantation in older adults vary across programs, but despite recent gains in access and the increased use of marginal organs, older patients remain less likely than other groups to receive a transplant, and those who do are highly selected. Moreover, few studies have addressed geriatric issues in transplant patient selection or management, or the implications on health span and disability when patients age to late life with a transplanted organ. This paper summarizes a recent trans-disciplinary workshop held by ASP, in collaboration with NHLBI, NIA, NIAID, NIDDK and AGS, to address issues related to kidney, liver, lung, or heart transplantation in older adults and to propose a research agenda in these areas.
authors.affiliation: Departments of Surgery and Microbiology-Immunology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
authors.forename: M
authors.initials: M
authors.lastname: Abecassis
authors.forename: N D
authors.initials: ND
authors.lastname: Bridges
authors.forename: C J
authors.initials: CJ
authors.lastname: Clancy
authors.forename: M A
authors.initials: MA
authors.lastname: Dew
authors.forename: B
authors.initials: B
authors.lastname: Eldadah
authors.forename: M J
authors.initials: MJ
authors.lastname: Englesbe
authors.forename: M F
authors.initials: MF
authors.lastname: Flessner
authors.forename: J C
authors.initials: JC
authors.lastname: Frank
authors.forename: J
authors.initials: J
authors.lastname: Friedewald
authors.forename: J
authors.initials: J
authors.lastname: Gill
authors.forename: C
authors.initials: C
authors.lastname: Gries
authors.forename: J B
authors.initials: JB
authors.lastname: Halter
authors.forename: E L
authors.initials: EL
authors.lastname: Hartmann
authors.forename: W R
authors.initials: WR
authors.lastname: Hazzard
authors.forename: F M
authors.initials: FM
authors.lastname: Horne
authors.forename: J
authors.initials: J
authors.lastname: Hosenpud
authors.forename: P
authors.initials: P
authors.lastname: Jacobson
authors.forename: B L
authors.initials: BL
authors.lastname: Kasiske
authors.forename: J
authors.initials: J
authors.lastname: Lake
authors.forename: R
authors.initials: R
authors.lastname: Loomba
authors.forename: P N
authors.initials: PN
authors.lastname: Malani
authors.forename: T M
authors.initials: TM
authors.lastname: Moore
authors.forename: A
authors.initials: A
authors.lastname: Murray
authors.forename: M-H
authors.initials: MH
authors.lastname: Nguyen
authors.forename: N R
authors.initials: NR
authors.lastname: Powe
authors.forename: P P
authors.initials: PP
authors.lastname: Reese
authors.forename: H
authors.initials: H
authors.lastname: Reynolds
authors.forename: M D
authors.initials: MD
authors.lastname: Samaniego
authors.forename: K E
authors.initials: KE
authors.lastname: Schmader
authors.forename: D L
authors.initials: DL
authors.lastname: Segev
authors.forename: A S
authors.initials: AS
authors.lastname: Shah
authors.forename: L G
authors.initials: LG
authors.lastname: Singer
authors.forename: J A
authors.initials: JA
authors.lastname: Sosa
authors.forename: Z A
authors.initials: ZA
authors.lastname: Stewart
authors.forename: J C
authors.initials: JC
authors.lastname: Tan
authors.forename: W W
authors.initials: WW
authors.lastname: Williams
authors.forename: D W
authors.initials: DW
authors.lastname: Zaas
authors.forename: K P
authors.initials: KP
authors.lastname: High
mesh_terms: D000368:Aged; D015276:Health Care Rationing; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D016377:Organ Transplantation; D018579:Patient Selection; D012935:Social Justice; D014019:Tissue Donors; D016896:Treatment Outcome
chemical_list: D007166:Immunosuppressive Agents