title: Incompatibility between propericiazine oral solution and tea-based drink.
abstract: Here, we studied the incompatibility between an oral solution of propericiazine (PCZ), an antipsychotic drug, and various commercially available bottled tea-based drinks. When 0.5 mL of the PCZ oral solution (10 mg/mL) was mixed with 16.5 mL of a tea-based drink (such as green tea, oolong tea, and black tea), the residual PCZ content declined to approximately 50% in some mixed solutions. After mixing with other tea-based drinks, the residual PCZ content declined to approximately 30%, while in others, it changed very little. The residual PCZ content declined immediately after mixing with tea-based drinks, but the rate remained almost unchanged for the next 24 h. Furthermore, the pH of the mixture increased to 4.5-5.1 after the oral solution of PCZ (original pH 3.8) was diluted with various tea-based drinks. Afterwards, the pH did not change for 24 h. The mixture became cloudy immediately after diluting PCZ oral solution with tea-based drinks, and the insoluble substance gradually precipitated. In order to elucidate factors responsible for the decline in the content of PCZ, a (-)-epigallocatechin gallate solution, which is a main ingredient of green tea polyphenol, was mixed with the PCZ oral solution. After mixing, the residual PCZ content declined to approximately 60-75%. On the other hand, the content of PCZ did not decline when a (-)-epigallocatechin solution was mixed with the PCZ oral solution. The results from this study demonstrated that PCZ content was reduced after dilution in tea-based drinks because of the interaction between PCZ and polyphenol with a galloyl group in tea-based drinks.
authors.affiliation: Faculty of Pharmaceutical Sciences, Fukuoka University, 8-19-1 Nanakuma, Fukuoka 814-0180, Japan. ikeda@fukuoka-u.ac.jp
authors.forename: Hirohito
authors.initials: H
authors.lastname: Ikeda
authors.forename: Erika
authors.initials: E
authors.lastname: Tsuji
authors.forename: Tomonori
authors.initials: T
authors.lastname: Matsubara
authors.forename: Miho
authors.initials: M
authors.lastname: Yukawa
authors.forename: Masao
authors.initials: M
authors.lastname: Fujisawa
authors.forename: Eiji
authors.initials: E
authors.lastname: Yukawa
authors.forename: Hatsumi
authors.initials: H
authors.lastname: Aki
mesh_terms: D000284:Administration, Oral; D014150:Antipsychotic Agents / Q000008:administration & dosage / Q000737:chemistry*; D002392:Catechin / Q000031:analogs & derivatives / Q000737:chemistry; D010640:Phenothiazines / Q000008:administration & dosage / Q000737:chemistry*; D013662:Tea / Q000737:chemistry*
chemical_list: D014150:Antipsychotic Agents; D010640:Phenothiazines; D013662:Tea; C084584:periciazine; D002392:Catechin; C045651:epigallocatechin gallate; C057580:gallocatechol