title: Potentials and challenges in self-nanoemulsifying drug delivery systems.
abstract: BACKGROUND
  A significant number of new chemical entities (almost 40%), that are outcome of contemporary drug discovery programs, have a potential therapeutic promise for patient, as they are highly potent but poorly water soluble resulting in reduced oral bioavailability. Self-nanoemulsifying drug delivery systems (SNEDDS) have emerged as a vital strategy to formulate these poorly soluble compounds for bioavailability enhancement.
  
  
  METHODS
  The review gives an insight about potential of SNEDDS with regards to oral drug delivery. The effect of various key constituents on formulation of SNEDDS and their applications in oral drug delivery is also discussed. Various aspects of formulation, characterization and biopharmaceutical aspects of SNEDDS are also been explored. The choice and selection of excipients for development of SNEDDS is also discussed.
  
  
  CONCLUSIONS
  The ability of SNEDDS to present the drug in single unit dosage form either as soft or hard gelatin capsule with enhanced solubility maintaining the uniformity of dose is unique. With the ease of large-scale production, high drug-loading capacity, improvement in release behavior of poorly water-soluble drugs and improvement of oral bioavailability, SNEDDS have emerged as preferable system for the formulation of drug compounds with bioavailability problems due to poor aqueous solubility.
authors.affiliation: Department of Pharmaceutics, Faculty of Pharmacy, Jamia Hamdard, Hamdard Nagar, New Delhi 110062, India. jali@jamiahamdard.ac.in
authors.forename: Abdul Wadood
authors.initials: AW
authors.lastname: Khan
authors.forename: Sabna
authors.initials: S
authors.lastname: Kotta
authors.forename: Shahid H
authors.initials: SH
authors.lastname: Ansari
authors.forename: Rakesh Kumar
authors.initials: RK
authors.lastname: Sharma
authors.forename: Javed
authors.initials: J
authors.lastname: Ali
mesh_terms: D000284:Administration, Oral; D001682:Biological Availability; D002214:Capsules; D004339:Drug Compounding; D016503:Drug Delivery Systems / Q000379:methods*; D004655:Emulsions; D005079:Excipients; D005780:Gelatin; D006801:Humans; D008055:Lipids; D004364:Pharmaceutical Preparations / Q000008:administration & dosage*; D012995:Solubility
chemical_list: D002214:Capsules; D004655:Emulsions; D005079:Excipients; D008055:Lipids; D004364:Pharmaceutical Preparations; D005780:Gelatin