title: Plasma alkylresorcinols, biomarkers of whole-grain intake, are related to lower BMI in older adults.
abstract: Alkylresorcinols (AR) are phenolic lipids found in the bran fraction of whole-grain wheat, rye, and barley. In intervention studies, plasma AR concentration increased in response to greater intakes of whole grain, wheat, and rye. This study examined the cross-sectional associations between plasma AR and habitual whole-grain intake, BMI, and metabolic risk factors in 407 free-living older adults (166 men and 241 women; aged 60-81y; median BMI: 27 kg/m(2)). Plasma AR were measured by liquid chromatography-tandem MS, and whole-grain intakes were estimated by using an FFQ. After adjustment for fasting TG concentrations, median plasma AR concentrations across quartile categories of AR were 5, 14, 27, and 62 nmol/L, respectively. Spearman correlation coefficients between plasma AR and whole-grain wheat-rich foods and total bran intake were 0.31 and 0.27, respectively (both P < 0.0001). After adjustment for multiple covariates, the geometric means of BMI in the lowest and highest quartile category of plasma AR were 27.6 and 26.7 kg/m(2), respectively (P-trend = 0.04). No associations were observed between plasma AR and glucose and insulin. Our study shows a dose-dependent relationship between whole-grain intake and plasma AR and confirms the previously observed inverse relationship between whole-grain intake and BMI using an independent biomarker of whole-grain wheat intake.
authors.affiliation: Nutrition Epidemiology Program, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA, USA.
authors.forename: Jiantao
authors.initials: J
authors.lastname: Ma
authors.forename: Alastair B
authors.initials: AB
authors.lastname: Ross
authors.forename: M Kyla
authors.initials: MK
authors.lastname: Shea
authors.forename: Stephen J
authors.initials: SJ
authors.lastname: Bruce
authors.forename: Paul F
authors.initials: PF
authors.lastname: Jacques
authors.forename: Edward
authors.initials: E
authors.lastname: Saltzman
authors.forename: Alice H
authors.initials: AH
authors.lastname: Lichtenstein
authors.forename: Sarah L
authors.initials: SL
authors.lastname: Booth
authors.forename: Nicola M
authors.initials: NM
authors.lastname: McKeown
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D015415:Biomarkers / Q000097:blood*; D001823:Body Composition; D015992:Body Mass Index; D003430:Cross-Sectional Studies; D004043:Dietary Fiber / Q000008:administration & dosage*; D002523:Edible Grain / Q000737:chemistry*; D002149:Energy Intake; D005247:Feeding Behavior; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D016032:Randomized Controlled Trials as Topic; D012118:Resorcinols / Q000097:blood*; D012307:Risk Factors
chemical_list: D015415:Biomarkers; D004043:Dietary Fiber; D012118:Resorcinols