title: Rho GTPases in pulmonary vascular dysfunction.
abstract: Rho proteins, best known for their regulatory role in actin dynamics, stimulate a variety of processes important in the control of vascular function, including morphogenesis, migration, cell proliferation and adhesion, cell survival, gene expression, vesicle transport and microparticle formation. Rho GTPases have been implicated in several pulmonary vascular pathologies. Here we give an overview of the current knowledge of the role of Rho GTPases in vascular dysfunction, and pulmonary diseases such as pulmonary hypertension, pulmonary embolism, chronic obstructive pulmonary disease, acute lung injury and acute respiratory distress syndrome.
authors.affiliation: Centre for Pharmacology and Therapeutics, Imperial College London, UK.
authors.forename: Elisabeth M
authors.initials: EM
authors.lastname: Storck
authors.forename: Beata
authors.initials: B
authors.lastname: Wojciak-Stothard
mesh_terms: D000199:Actins / Q000378:metabolism; D000818:Animals; D006801:Humans; D006976:Hypertension, Pulmonary / Q000503:physiopathology; D008171:Lung Diseases / Q000503:physiopathology*; D011652:Pulmonary Circulation; D014652:Vascular Diseases / Q000503:physiopathology*; D020741:rho GTP-Binding Proteins / Q000378:metabolism*
chemical_list: D000199:Actins; D020741:rho GTP-Binding Proteins