title: Dental composites and amalgam and physical development in children.
abstract: Resin-based composite dental restoration materials may release bisphenol-A, an endocrine-disrupting chemical. Using secondary analysis of a randomized clinical safety trial of amalgam vs. composites, we tested the hypothesis that dental restoration materials affect children's growth. Children (N = 218 boys, N = 256 girls) aged 6 to 10 yrs at baseline with ≥ 2 decayed posterior teeth were randomized to amalgam or composites (bisphenol-A-diglycidyl-dimethacrylate composite for permanent teeth, urethane-dimethacrylate compomer for primary teeth) for treatment of posterior caries throughout follow-up. Primary outcomes for this analysis were 5-year changes in BMI-for-age z-scores, body fat percentage (BF%), and height velocity; exploratory analyses (n = 113) examined age at menarche. Results showed no significant differences between treatment assignment and changes in physical development in boys [(composites vs. amalgam) BF%, 4.9 vs. 5.7, p = 0.49; (BMI-z-score) 0.13 vs. 0.25, p = 0.36] or girls (8.8 vs. 7.7, p = 0.95; 0.36 vs. 0.21, p = 0.49). Children with more treatment on primary teeth had greater increases in BF% regardless of material type. Girls assigned to composites had lower risk of menarche during follow-up (hazard ratio = 0.57, 95% CI 0.35-0.95). Overall, there were no significant differences in physical development over 5 years in children treated with composites or amalgam. Additional studies examining these restoration materials in relation to age at menarche are warranted (clinicaltrials.gov number NCT00065988).
authors.affiliation: New England Research Institutes, 9 Galen Street, Watertown, MA 02472, USA. nmaserejian@neriscience.com
authors.forename: N N
authors.initials: NN
authors.lastname: Maserejian
authors.forename: R
authors.initials: R
authors.lastname: Hauser
authors.forename: M
authors.initials: M
authors.lastname: Tavares
authors.forename: F L
authors.initials: FL
authors.lastname: Trachtenberg
authors.forename: P
authors.initials: P
authors.lastname: Shrader
authors.forename: S
authors.initials: S
authors.lastname: McKinlay
mesh_terms: D000273:Adipose Tissue / Q000187:drug effects; D000704:Analysis of Variance; D001559:Benzhydryl Compounds; D001827:Body Height / Q000187:drug effects; D015992:Body Mass Index; D002648:Child; D002657:Child Development / Q000187:drug effects*; D003188:Composite Resins / Q000009:adverse effects* / Q000737:chemistry; D003723:Dental Amalgam / Q000009:adverse effects*; D003793:Dental Restoration, Permanent / Q000009:adverse effects* / Q000379:methods; D004968:Estrogens, Non-Steroidal / Q000009:adverse effects*; D005260:Female; D006801:Humans; D016014:Linear Models; D008297:Male; D008572:Menarche / Q000187:drug effects; D008689:Methacrylates / Q000009:adverse effects; D010636:Phenols / Q000009:adverse effects*; D011140:Polyurethanes / Q000009:adverse effects; D012737:Sex Factors; D000098826:Bisphenol A Compounds
chemical_list: D001559:Benzhydryl Compounds; D003188:Composite Resins; D003723:Dental Amalgam; D004968:Estrogens, Non-Steroidal; D008689:Methacrylates; D010636:Phenols; D011140:Polyurethanes; C029824:urethane dimethacrylate luting resin; C006780:bisphenol A; D000098826:Bisphenol A Compounds