title: The surgical treatment of breast cancer in the elderly: a single institution comparative review of 5235 patients with 1028 patients ≥70 years.
abstract: As the wave of the baby boomers shifts the age demographic of patients, the current surgical management of breast cancer in elderly women (≥70 years of age) becomes relevant because deviation from standard treatment often occurs in this group. The purpose of this study was to determine the operative mortality when treated with standard surgical procedures and to investigate trends in the surgical management of breast cancer in the elderly. A total of 5,235 patients undergoing either mastectomy or breast conservation surgery (BCS) for invasive and ductal carcinoma in situ (DCIS) were identified in a retrospective review of a prospectively accrued data base between the years of 1994 and 2007 at the Moffitt Cancer Center. Of the 5,235 patients, 1,028 (20%) patients were ≥70 years of age. The 30-day and 90-day mortality in the elderly group (age ≥70 years) was 0.2% (95% CI 0.02-0.7%) and 0.7% (95% CI 0.3-1.4%), respectively. The 30-day and 90-day mortality among patients <70 years was 0 and 0.05% (2 of 4,207 patients) (95% CI 0.005-0.2), respectively. BCS rates for invasive carcinomas were the highest for patients between 40 and 70 years of age, whereas the mastectomy rates were higher among patients <40 years of age (53%). Elderly women were as likely as women <40 years to have BCS for invasive carcinoma (OR 1.1, 95% CI 0.8-1.5), but more likely to have BCS for DCIS (OR 1.9, 95% CI 1.1-3.3). Surgical mortality in elderly women treated for breast cancer was extremely low and was related to the extent of surgery performed. Breast cancer treatment differed by age groups.
authors.affiliation: The University of South Florida, Department of Surgery, and H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida 33612, USA.
authors.forename: Paramjeet
authors.initials: P
authors.lastname: Kaur
authors.forename: Alfredo A
authors.initials: AA
authors.lastname: Santillan
authors.forename: Kandace
authors.initials: K
authors.lastname: McGuire
authors.forename: Kiran K
authors.initials: KK
authors.lastname: Turaga
authors.forename: Corinne
authors.initials: C
authors.lastname: Shamehdi
authors.forename: Tammi
authors.initials: T
authors.lastname: Meade
authors.forename: Daniel
authors.initials: D
authors.lastname: Ramos
authors.forename: Morgan
authors.initials: M
authors.lastname: Mathias
authors.forename: Jateen
authors.initials: J
authors.lastname: Parbhoo
authors.forename: Michelle
authors.initials: M
authors.lastname: Davis
authors.forename: Nazanin
authors.initials: N
authors.lastname: Khakpour
authors.forename: Jeff
authors.initials: J
authors.lastname: King
authors.forename: Lodovico
authors.initials: L
authors.lastname: Balducci
authors.forename: Charles E
authors.initials: CE
authors.lastname: Cox
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001943:Breast Neoplasms / Q000401:mortality* / Q000601:surgery*; D002285:Carcinoma, Intraductal, Noninfiltrating / Q000401:mortality* / Q000601:surgery*; D005260:Female; D006801:Humans; D016015:Logistic Models; D008408:Mastectomy / Q000379:methods / Q000401:mortality* / Q000706:statistics & numerical data; D015412:Mastectomy, Segmental / Q000379:methods / Q000401:mortality / Q000706:statistics & numerical data; D008875:Middle Aged; D012189:Retrospective Studies