title: Animal models in virus research: their utility and limitations.
abstract: Viral diseases are important threats to public health worldwide. With the number of emerging viral diseases increasing the last decades, there is a growing need for appropriate animal models for virus studies. The relevance of animal models can be limited in terms of mimicking human pathophysiology. In this review, we discuss the utility of animal models for studies of influenza A viruses, HIV and SARS-CoV in light of viral emergence, assessment of infection and transmission risks, and regulatory decision making. We address their relevance and limitations. The susceptibility, immune responses, pathogenesis, and pharmacokinetics may differ between the various animal models. These complexities may thwart translating results from animal experiments to the humans. Within these constraints, animal models are very informative for studying virus immunopathology and transmission modes and for translation of virus research into clinical benefit. Insight in the limitations of the various models may facilitate further improvements of the models.
authors.affiliation: National Institute for Public Health and the Environment (RIVM), GMO Office , Bilthoven , The Netherlands.
authors.forename: Derrick
authors.initials: D
authors.lastname: Louz
authors.forename: Hans E
authors.initials: HE
authors.lastname: Bergmans
authors.forename: Birgit P
authors.initials: BP
authors.lastname: Loos
authors.forename: Rob C
authors.initials: RC
authors.lastname: Hoeben
mesh_terms: D000818:Animals; D035843:Biomedical Research / Q000379:methods*; D004195:Disease Models, Animal; D006678:HIV / Q000276:immunology / Q000472:pathogenicity; D006801:Humans; D009980:Influenza A virus / Q000276:immunology / Q000472:pathogenicity; D045473:Severe acute respiratory syndrome-related coronavirus / Q000276:immunology / Q000472:pathogenicity; D014777:Virus Diseases / Q000276:immunology / Q000473:pathology / Q000821:virology*