title: Adjunctive treatment with gabapentin in bipolar patients during acute mania.
abstract: OBJECTIVE
  In this clinical trial, we studied the effects of adjunctive treatment with gabapentin in controlling the symptoms of acute mania in patients admitted with bipolar disorder.
  
  
  METHODS
  Sixty patients with bipolar disorder (30 men and 30 women) admitted in the acute phase of mania were categorized as case and control groups, each holding 30 patients. Both groups were treated with lithium for 6 weeks and the case group received an adjunctive treatment with 900 mg gabapentin simultaneously. All patients were evaluated at the beginning and the end of the trial using Young's Mania Rating Scale (YMRS), and two groups were compared for improvement in acute symptoms.
  
  
  RESULTS
  The final score of YMRS was significantly improved in the case group compared to the control group (p = 0.00). The improvement of YMRS score was not significantly different between men and women and between different age groups.
  
  
  CONCLUSIONS
  Adjunctive treatment with gabapentin is effective for controlling symptoms of acute mania.
authors.affiliation: University of Social Welfare and Rehabilitation Sciences, Tehran, Iran.
authors.forename: Ali Nazeri
authors.initials: AN
authors.lastname: Astaneh
authors.forename: Omid
authors.initials: O
authors.lastname: Rezaei
mesh_terms: D000208:Acute Disease; D017677:Age Distribution; D000588:Amines / Q000627:therapeutic use*; D000704:Analysis of Variance; D018692:Antimanic Agents / Q000627:therapeutic use*; D001714:Bipolar Disorder / Q000150:complications / Q000188:drug therapy* / Q000209:etiology; D003509:Cyclohexanecarboxylic Acids / Q000627:therapeutic use*; D004359:Drug Therapy, Combination / Q000379:methods; D005260:Female; D000077206:Gabapentin; D006801:Humans; D007492:Iran; D018020:Lithium Compounds / Q000008:administration & dosage; D008297:Male; D011569:Psychiatric Status Rating Scales / Q000706:statistics & numerical data; D017678:Sex Distribution; D016896:Treatment Outcome; D005680:gamma-Aminobutyric Acid / Q000627:therapeutic use*
chemical_list: D000588:Amines; D018692:Antimanic Agents; D003509:Cyclohexanecarboxylic Acids; D018020:Lithium Compounds; D005680:gamma-Aminobutyric Acid; D000077206:Gabapentin