title: Design of new quantum dot materials for deep tissue infrared imaging.
abstract: Near infrared fluorescence offers several advantages for tissue and in vivo imaging thanks to deeper photon penetration. In this article, we review a promising class of near infrared emitting probes based on semiconductor quantum dots (QDs), which have the potential to considerably improve in vivo fluorescence imaging thanks to their high brightness and stability. We discuss in particular the different criteria to optimize the design of near infrared QDs. We present the recent developments in the synthesis of novel QD materials and their different in vivo imaging applications, including lymph node localization, vasculature imaging, tumor localization, as well as cell tracking and QD-based multimodal probes.
authors.affiliation: LPEM, ESPCI/CNRS/UPMC UMR 8213, 10, Rue Vauquelin, 75005 Paris, France.
authors.forename: Elsa
authors.initials: E
authors.lastname: Cassette
authors.forename: Marion
authors.initials: M
authors.lastname: Helle
authors.forename: Lina
authors.initials: L
authors.lastname: Bezdetnaya
authors.forename: Frédéric
authors.initials: F
authors.lastname: Marchal
authors.forename: Benoit
authors.initials: B
authors.lastname: Dubertret
authors.forename: Thomas
authors.initials: T
authors.lastname: Pons
mesh_terms: D000818:Animals; D003952:Diagnostic Imaging / Q000379:methods*; D015195:Drug Design; D006801:Humans; D045663:Quantum Dots; D019265:Spectroscopy, Near-Infrared / Q000379:methods*; D014018:Tissue Distribution / Q000502:physiology