title: Regio- and diastereoselective nickel-catalyzed allylation of aromatic aldehydes with α-halo-β,β-difluoropropene derivatives.
abstract: A one-pot nickel-catalyzed allylation of aromatic aldehydes with α-halo-β,β-difluoropropene-containing compounds promoted by ZnEt(2) under mild conditions was described. The reaction displays moderate to good regio- and diastereoselectivity, tolerates a wide range of functional groups, and provides an efficient method for the synthesis of γ-fluorinated homoallylic alcohols.
authors.affiliation: Key Laboratory of Organofluorine Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Lu, Shanghai 200032, China.
authors.forename: Xiaowei
authors.initials: X
authors.lastname: Lin
authors.forename: Feng
authors.initials: F
authors.lastname: Zheng
authors.forename: Feng-Ling
authors.initials: FL
authors.lastname: Qing
mesh_terms: D000447:Aldehydes / Q000737:chemistry*; D000498:Allyl Compounds / Q000737:chemistry*; D002384:Catalysis; D006845:Hydrocarbons, Fluorinated / Q000737:chemistry*; D009532:Nickel / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: C572308:3,3-difluoropropene; D000447:Aldehydes; D000498:Allyl Compounds; D006845:Hydrocarbons, Fluorinated; D009532:Nickel