title: Laparoscopic adrenalectomy for co-secreting aldosterone and cortisol adenomas.
abstract: There are few published data on aldosterone and cortisol co-secreting adrenal tumours. Failure to perform comprehensive preoperative endocrine investigations in patients with adrenal "incidentalomas" or in those thought to be secreting only one hormone may account for this. Clinically patients with such lesions may have evidence of hypertension and hypokalaemia with no features of cortisol excess. Preoperative diagnosis of such lesions with accurate endocrinological work up is essential to prevent adrenal insufficiency and haemodynamic crises following removal of such glands. We present a series of 4 patients with co-secreting tumours treated by laparoscopic adrenalectomy between September 2010 and March 2011. Our experience suggests that dual secretors are more common than originally thought. A high index of suspicion and adequate endocrine work up is paramount in diagnosing such tumours and in experienced hands, laparoscopic adrenalectomy with appropriate substitutive steroid cover is safe, feasible and curative for these functioning adrenal tumours.
authors.affiliation: Department of Surgery and Endocrinology, St George's Healthcare NHS Trust, Blackshaw Road, Tooting, London SW17 0QT, UK. cheryllobo@doctors.org.uk
authors.forename: C R
authors.initials: CR
authors.lastname: Lobo
authors.forename: A
authors.initials: A
authors.lastname: Kolinioti
authors.forename: A J
authors.initials: AJ
authors.lastname: Hainsworth
authors.forename: G
authors.initials: G
authors.lastname: Bano
authors.forename: S S
authors.initials: SS
authors.lastname: Mudan
authors.forename: A K
authors.initials: AK
authors.lastname: Sharma
mesh_terms: D000236:Adenoma / Q000175:diagnosis / Q000378:metabolism* / Q000601:surgery; D000310:Adrenal Gland Neoplasms / Q000175:diagnosis / Q000378:metabolism* / Q000601:surgery*; D000315:Adrenalectomy / Q000379:methods*; D000368:Aged; D000369:Aged, 80 and over; D000450:Aldosterone / Q000097:blood / Q000378:metabolism*; D005260:Female; D006801:Humans; D006854:Hydrocortisone / Q000097:blood / Q000378:metabolism*; D010535:Laparoscopy / Q000379:methods*; D008297:Male; D019990:Perioperative Care; D014057:Tomography, X-Ray Computed
chemical_list: D000450:Aldosterone; D006854:Hydrocortisone