title: Qualitative screening in doping control by MALDI-TOF/TOF mass spectrometry: a proof-of-evidence.
abstract: The analysis of doping agents in biological fluids is of top significance in clinical and forensic toxicology. Herein we describe the study of a screening method for the detection of a mixture of drugs of potential abuse including cocaine and its metabolites. By using matrix-assisted laser desorption/ionization MALDI-TOF/TOF mass spectrometry. This screening procedure to detect the presence of different drugs, avoiding time consuming procedures could be useful in different fields of forensic analytical toxicology, including antidoping analysis.
authors.affiliation: Department of Organic Chemistry and Biochemistry, University of Naples Federico II, Naples, Italy. eugenio.galano@unina.it
authors.forename: E
authors.initials: E
authors.lastname: Galano
authors.forename: M
authors.initials: M
authors.lastname: Fidani
authors.forename: F
authors.initials: F
authors.lastname: Baia
authors.forename: L
authors.initials: L
authors.lastname: Palomba
authors.forename: G
authors.initials: G
authors.lastname: Marino
authors.forename: A
authors.initials: A
authors.lastname: Amoresano
mesh_terms: D000818:Animals; D003042:Cocaine / Q000097:blood* / Q000737:chemistry / Q000652:urine*; D006736:Horses; D006801:Humans; D013287:Illicit Drugs / Q000097:blood* / Q000652:urine*; D015203:Reproducibility of Results; D019032:Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization / Q000379:methods*; D015813:Substance Abuse Detection / Q000379:methods; D053719:Tandem Mass Spectrometry / Q000379:methods*
chemical_list: D013287:Illicit Drugs; D003042:Cocaine