title: Prevalence, risk factors and molecular epidemiology of methicillin-resistant Staphylococcus aureus (MRSA) colonization in residents of long-term care facilities in Luxembourg, 2010.
abstract: A prevalence survey of methicillin-resistant Staphylococcus aureus (MRSA) was performed in 2010 in 19 long-term care facilities in Luxembourg. Of the 954 participating residents, 69 (7·2%) were colonized by MRSA. Previous history of MRSA [odds ratio (OR) 7·20, 95% confidence interval (CI) 3·19-16·27], quinolone therapy in the previous year (OR 2·27, 95% CI 1·17-4·41) and ≥24 h care administered per week (OR 4·29, 95% CI 1·18-15·56) were independent risk factors for MRSA colonization. More than 75% of strains were of clonal complex (CC)5, mainly spa-type t003 or sequence type (ST)225 and ST710, which is a rapidly emerging lineage prevalent in central Europe. Five residents were colonized by livestock-associated genotypes belonging to CC398. Previously dominant CC8 strains have recently been replaced by more resistant CC5 strains in Luxembourg.
authors.affiliation: Surveillance & Epidemiology of Infectious Diseases, National Health Laboratory, Luxembourg. joelmossong@gmail.com
authors.forename: J
authors.initials: J
authors.lastname: Mossong
authors.forename: E
authors.initials: E
authors.lastname: Gelhausen
authors.forename: F
authors.initials: F
authors.lastname: Decruyenaere
authors.forename: A
authors.initials: A
authors.lastname: Devaux
authors.forename: M
authors.initials: M
authors.lastname: Perrin
authors.forename: J
authors.initials: J
authors.lastname: Even
authors.forename: E
authors.initials: E
authors.lastname: Heisbourg
mesh_terms: D000368:Aged; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D003430:Cross-Sectional Studies; D005260:Female; D005838:Genotype; D006801:Humans; D016015:Logistic Models; D008134:Long-Term Care / Q000706:statistics & numerical data*; D008189:Luxembourg / Q000453:epidemiology; D008297:Male; D055624:Methicillin-Resistant Staphylococcus aureus / Q000235:genetics; D017720:Molecular Epidemiology; D016017:Odds Ratio; D015995:Prevalence; D015363:Quinolones / Q000627:therapeutic use; D012307:Risk Factors; D013203:Staphylococcal Infections / Q000453:epidemiology* / Q000209:etiology / Q000235:genetics
chemical_list: D000900:Anti-Bacterial Agents; D015363:Quinolones