title: Two new glycosidated coumaramides from Clerodendron cyrtophyllum.
abstract: Two new glycosidated coumaramides clerodendiod A (1) and B (2), together with seven known glycosidic compounds were isolated from the branches of Clerodendron cyrtophyllum Turcz. Clerodendiod A and B were elucidated as β-D-glucopyranosyl-(1→3)-β-D-glucopyranosyl-(1→3)-[6-O-(E)-p-methoxycinnamoyl]-β-D-glucopyranosyl-(1→2)-[4-O-((E)-2-(4-acetamidobutylcarbamoyl)vinyl)-phenyl]-α-L-rhamnopyranoside (1) and 6-O-(E)-p-coumaroyl-β-D-glucopyranosyl-(1→3)-β-D-glucopyranosyl-(1→3)-[6-O-(E)-p-methoxycinnamoyl]-β-D-glucopyranosyl-(1→2)-[4-O-((E)-2-(4-acetamidobutylcarbamoyl)vinyl)-phenyl]-α-L-rhamnopyranoside (2) on the basis of chemical and spectral evidence. The isolated new compound 2 was assayed for the inhibition of the NF-κB pathway and showed potent activity in inhibiting NF-κB which its IC(50) values was found to be 24.9 nM.
authors.affiliation: School of Pharmacy, Shanghai University of Traditional Chinese Medicine, 1200 Cailun Road, Shanghai, 201203, PR China.
authors.forename: Peng
authors.initials: P
authors.lastname: Wang
authors.forename: Li
authors.initials: L
authors.lastname: Sun
authors.forename: Junjie
authors.initials: J
authors.lastname: Tan
authors.forename: Jinwen
authors.initials: J
authors.lastname: Xu
authors.forename: Fujiang
authors.initials: F
authors.lastname: Guo
authors.forename: Yiming
authors.initials: Y
authors.lastname: Li
mesh_terms: D000893:Anti-Inflammatory Agents / Q000737:chemistry / Q000494:pharmacology; D002934:Cinnamates / Q000737:chemistry*; D032409:Clerodendrum / Q000737:chemistry*; D006027:Glycosides / Q000737:chemistry*; D057809:HEK293 Cells; D006801:Humans; D015394:Molecular Structure; D016328:NF-kappa B / Q000037:antagonists & inhibitors
chemical_list: D000893:Anti-Inflammatory Agents; D002934:Cinnamates; D006027:Glycosides; D016328:NF-kappa B; C581116:clerodendiod A; C581117:clerodendiod B