title: In vivo investigation on the potential of galangin, kaempferol and myricetin for protection of D-galactose-induced cognitive impairment.
abstract: The potential of three natural flavonols (galangin, kaempferol and myricetin) to protect against D-galactose-induced cognitive impairment in mice was investigated. After 8 weeks treatment, the mice were assessed by behavioural tests. The levels of oxidative stress, the amount of Na(+),K(+)-ATPase and extracellular signal-regulated kinases (ERK)-cyclic AMP response element binding protein (CREB) signaling pathway in hippocampus were also analysed. It was found that all the three dietary flavonols could ameliorate the oxidative stress, enhance the activity of Na(+),K(+)-ATPase and regulate the expression of ERK-CREB pathway in mice. However, only kaempferol and myricetin could significantly improve the learning and memory capability when compared with D-galactose model. Our results suggest that the presence of hydroxyl groups in the B ring of flavonols may have contribution to the neuroprotective activity.
authors.affiliation: Department of Pharmacy, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
authors.forename: Yongfang
authors.initials: Y
authors.lastname: Lei
authors.forename: Jinglou
authors.initials: J
authors.lastname: Chen
authors.forename: Wenting
authors.initials: W
authors.lastname: Zhang
authors.forename: Wei
authors.initials: W
authors.lastname: Fu
authors.forename: Guanghua
authors.initials: G
authors.lastname: Wu
authors.forename: Han
authors.initials: H
authors.lastname: Wei
authors.forename: Qing
authors.initials: Q
authors.lastname: Wang
authors.forename: Jinlan
authors.initials: J
authors.lastname: Ruan
mesh_terms: D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects; D003072:Cognition Disorders / Q000139:chemically induced / Q000188:drug therapy* / Q000378:metabolism* / Q000523:psychology; D017362:Cyclic AMP Response Element-Binding Protein / Q000235:genetics / Q000378:metabolism; D048049:Extracellular Signal-Regulated MAP Kinases / Q000235:genetics / Q000378:metabolism; D005419:Flavonoids / Q000008:administration & dosage*; D005690:Galactose / Q000009:adverse effects; D006624:Hippocampus / Q000187:drug effects / Q000378:metabolism; D006801:Humans; D044949:Kaempferols / Q000008:administration & dosage*; D008297:Male; D051379:Mice; D018696:Neuroprotective Agents / Q000008:administration & dosage*; D018384:Oxidative Stress / Q000187:drug effects*; D015398:Signal Transduction / Q000187:drug effects
chemical_list: D017362:Cyclic AMP Response Element-Binding Protein; D005419:Flavonoids; D044949:Kaempferols; D018696:Neuroprotective Agents; C037032:galangin; C006552:kaempferol; C040015:myricetin; D048049:Extracellular Signal-Regulated MAP Kinases; D005690:Galactose