title: Preparation of dicationic palladium catalysts for asymmetric catalytic reactions.
abstract: The synthesis of Pd(OTf)(2)·2H(2)O is described. This was used to generate two different types of chiral dicationic palladium complexes for highly enantioselective addition of aromatic amines to α, β-unsaturated conjugate alkenes ([(R-BINAP)Pd(OH(2))(2)][OTf](2) and [(R-BINAP)Pd(μ-OH)](2)[OTf](2)). The resulting optically active N-arylated β-amino acid derivatives are valuable synthetic intermediates for the synthesis of biologically active molecules and peptidomimetics. The reaction of (2E)-but-2-enoylcarbamate and aniline is shown as an example of the use of these catalysts for enantioselective aza-Michael addition. For the preparation of palladium(II) triflate, the time scale is 20 h 50 min, plus 5 h 15 min for the monomeric complex and plus 6 h 45 min for the dimeric complex.
authors.affiliation: Department of Chemistry, Imperial College London, South Kensington, London, UK.
authors.forename: Andrey E
authors.initials: AE
authors.lastname: Sheshenev
authors.forename: Alexander M R
authors.initials: AM
authors.lastname: Smith
authors.forename: King Kuok Mimi
authors.initials: KK
authors.lastname: Hii
mesh_terms: D002384:Catalysis; D002621:Chemistry / Q000295:instrumentation / Q000379:methods; D010165:Palladium / Q000737:chemistry*
chemical_list: D010165:Palladium