title: Transcriptional elongation and alternative splicing.
abstract: Alternative splicing has emerged as a key contributor to proteome diversity, highlighting the importance of understanding its regulation. In recent years it became apparent that splicing is predominantly cotranscriptional, allowing for crosstalk between these two nuclear processes. We discuss some of the links between transcription and splicing, with special emphasis on the role played by transcription elongation in the regulation of alternative splicing events and in particular the kinetic model of alternative splicing regulation. This article is part of a Special Issue entitled: RNA polymerase II Transcript Elongation.
authors.affiliation: Departamento de Fisiología, Universidad de Buenos Aires, Ciudad Universitaria, Buenos Aires, Argentina.
authors.forename: Gwendal
authors.initials: G
authors.lastname: Dujardin
authors.forename: Celina
authors.initials: C
authors.lastname: Lafaille
authors.forename: Ezequiel
authors.initials: E
authors.lastname: Petrillo
authors.forename: Valeria
authors.initials: V
authors.lastname: Buggiano
authors.forename: Luciana I
authors.initials: LI
authors.lastname: Gómez Acuña
authors.forename: Ana
authors.initials: A
authors.lastname: Fiszbein
authors.forename: Micaela A
authors.initials: MA
authors.lastname: Godoy Herz
authors.forename: Nicolás
authors.initials: N
authors.lastname: Nieto Moreno
authors.forename: Manuel J
authors.initials: MJ
authors.lastname: Muñoz
authors.forename: Mariano
authors.initials: M
authors.lastname: Alló
authors.forename: Ignacio E
authors.initials: IE
authors.lastname: Schor
authors.forename: Alberto R
authors.initials: AR
authors.lastname: Kornblihtt
mesh_terms: D017398:Alternative Splicing / Q000235:genetics / Q000502:physiology*; D000818:Animals; D002843:Chromatin / Q000737:chemistry / Q000378:metabolism / Q000502:physiology; D006801:Humans; D007700:Kinetics; D008954:Models, Biological; D011485:Protein Binding / Q000502:physiology; D012319:RNA Polymerase II / Q000378:metabolism / Q000502:physiology; D061805:Transcription Elongation, Genetic / Q000502:physiology*
chemical_list: D002843:Chromatin; D012319:RNA Polymerase II