title: Human herpesvirus 6 latent infection in patients with glioma.
abstract: The etiology of glioma remains unclear so far. Human herpesvirus 6 (HHV-6) might be associated with glioma, but there is no direct evidence to support this. High percentages of HHV-6 DNA and protein were detected in tissue from gliomas, compared with normal brain tissue. In addition, a strain of HHV-6A was isolated from the fluid specimens from glioma cysts. High levels of interleukin 6 (IL-6), interleukin 8 (IL-8), tumor necrosis factor α, and transforming growth factor β (TGF-β) were detected in the cyst fluid specimens from HHV-6-positive patients with glioma. Furthermore, HHV-6A infection promoted IL-6, IL-8, and TGF-β production in astrocyte cultures. Our studies strongly suggest the involvement of HHV-6 infection in the pathogenesis of glioma.
authors.affiliation: Department of Microbiology and Immunology, Nanjing Medical University, China.
authors.forename: Jing
authors.initials: J
authors.lastname: Chi
authors.forename: Bin
authors.initials: B
authors.lastname: Gu
authors.forename: Chun
authors.initials: C
authors.lastname: Zhang
authors.forename: Guangyong
authors.initials: G
authors.lastname: Peng
authors.forename: Feng
authors.initials: F
authors.lastname: Zhou
authors.forename: Yun
authors.initials: Y
authors.lastname: Chen
authors.forename: Guofeng
authors.initials: G
authors.lastname: Zhang
authors.forename: Yidi
authors.initials: Y
authors.lastname: Guo
authors.forename: Dandan
authors.initials: D
authors.lastname: Guo
authors.forename: Jian
authors.initials: J
authors.lastname: Qin
authors.forename: Jinfeng
authors.initials: J
authors.lastname: Wang
authors.forename: Lingyun
authors.initials: L
authors.lastname: Li
authors.forename: Fang
authors.initials: F
authors.lastname: Wang
authors.forename: Genyan
authors.initials: G
authors.lastname: Liu
authors.forename: Fangyi
authors.initials: F
authors.lastname: Xie
authors.forename: Dongju
authors.initials: D
authors.lastname: Feng
authors.forename: Hong
authors.initials: H
authors.lastname: Zhou
authors.forename: Xingxu
authors.initials: X
authors.lastname: Huang
authors.forename: Shiqiang
authors.initials: S
authors.lastname: Lu
authors.forename: Yingxia
authors.initials: Y
authors.lastname: Liu
authors.forename: Weixing
authors.initials: W
authors.lastname: Hu
authors.forename: Kun
authors.initials: K
authors.lastname: Yao
mesh_terms: D000328:Adult; D000368:Aged; D058070:Asymptomatic Diseases; D002353:Carrier State / Q000453:epidemiology / Q000821:virology; D016207:Cytokines / Q000378:metabolism; D005260:Female; D005910:Glioma / Q000209:etiology / Q000821:virology*; D015654:Herpesvirus 6, Human / Q000302:isolation & purification*; D006801:Humans; D008297:Male; D008875:Middle Aged; D019349:Roseolovirus Infections / Q000150:complications / Q000453:epidemiology* / Q000821:virology*; D055815:Young Adult
chemical_list: D016207:Cytokines