title: Iron-catalyzed cross-coupling of N-heterocyclic chlorides and bromides with arylmagnesium reagents.
abstract: A simple, practical iron salt catalyzed procedure allows fast cross-couplings of N-heterocyclic chlorides and bromides with various electron-rich and -poor arylmagnesium reagents. A solvent mixture of THF and tBuOMe is found to be essential for achieving high yields mainly by avoiding homocoupling side reactions.
authors.affiliation: Department Chemie, Ludwig-Maximilians-Universität München, Butenandtstr. 5-13, 81377 München, Germany.
authors.forename: Olesya M
authors.initials: OM
authors.lastname: Kuzmina
authors.forename: Andreas K
authors.initials: AK
authors.lastname: Steib
authors.forename: Dietmar
authors.initials: D
authors.lastname: Flubacher
authors.forename: Paul
authors.initials: P
authors.lastname: Knochel
mesh_terms: D001896:Boron Compounds / Q000737:chemistry*; D001897:Boronic Acids / Q000737:chemistry*; D002384:Catalysis; D006842:Hydrocarbons, Brominated / Q000138:chemical synthesis / Q000737:chemistry*; D006843:Hydrocarbons, Chlorinated / Q000138:chemical synthesis / Q000737:chemistry*; D007202:Indicators and Reagents; D007501:Iron / Q000737:chemistry*; D008274:Magnesium / Q000737:chemistry*; D015394:Molecular Structure; D009942:Organometallic Compounds / Q000737:chemistry*
chemical_list: D001896:Boron Compounds; D001897:Boronic Acids; D006842:Hydrocarbons, Brominated; D006843:Hydrocarbons, Chlorinated; D007202:Indicators and Reagents; D009942:Organometallic Compounds; D007501:Iron; D008274:Magnesium