title: Two new nonacosanetriols from Ginkgo biloba sarcotesta.
abstract: Two new fatty alcohols named as (7S,8R,11S)-nonacosanetriol (1) and (10R,12R,15S)-nonacosanetriol (2), along with eight known compounds including ginkgolic acid (3), hydroginkgolic acid (4), sciadopitysin (5), ginkgetin (6), isoginkgetin (7), ginkgolide A (8), ginkgolide B (9) and ginkgolide C (10) have been isolated from the petroleum ether extract of Ginkgo biloba sarcotesta. Their structures were elucidated by means of chemical and extensive spectroscopic analysis. The absolute stereochemistry of compounds 1 and 2 was elucidated on the spectroscopic analysis of the R- and S-MTPA esters. Compounds 1 and 2 exhibited slight activity of antithrombin and moderate activity of antiplatelet aggregation in vitro. This was the first report regarding the anticoagulative activities of biflavonoids in G. biloba, and isoginkgetin (7) showed significant antithrombin and antiplatelet aggregation activity.
authors.affiliation: Jiangsu Key Laboratory for High Technology of TCM Formulae Research, Nanjing University of Chinese Medicine, Nanjing 210046, China.
authors.forename: Guisheng
authors.initials: G
authors.lastname: Zhou
authors.forename: Xin
authors.initials: X
authors.lastname: Yao
authors.forename: Yuping
authors.initials: Y
authors.lastname: Tang
authors.forename: Nianyun
authors.initials: N
authors.lastname: Yang
authors.forename: Hanqing
authors.initials: H
authors.lastname: Pang
authors.forename: Xuan
authors.initials: X
authors.lastname: Mo
authors.forename: Shaoqing
authors.initials: S
authors.lastname: Zhu
authors.forename: Shulan
authors.initials: S
authors.lastname: Su
authors.forename: Dawei
authors.initials: D
authors.lastname: Qian
authors.forename: Chun
authors.initials: C
authors.lastname: Jin
authors.forename: Yong
authors.initials: Y
authors.lastname: Qin
authors.forename: Jin-ao
authors.initials: JA
authors.lastname: Duan
mesh_terms: D000107:Acetylation; D000818:Animals; D000925:Anticoagulants / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D001777:Blood Coagulation / Q000187:drug effects; D002850:Chromatography, Gel; D002855:Chromatography, Thin Layer; D005233:Fatty Alcohols / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D020441:Ginkgo biloba / Q000737:chemistry*; D066298:In Vitro Techniques; D015394:Molecular Structure; D011817:Rabbits; D021241:Spectrometry, Mass, Electrospray Ionization; D013237:Stereoisomerism; D053719:Tandem Mass Spectrometry; D044366:Transition Temperature
chemical_list: C579829:(7S,8R,11S)-nonacosanetriol; D000925:Anticoagulants; D005233:Fatty Alcohols