title: Changes in phospholipid composition of erythrocyte membrane in Alzheimer's disease.
abstract: BACKGROUND
  There are several reports indicating a decrease of ethanolamine plasmalogen (pl-PE) in brain tissues and in serum of patients with Alzheimer's disease (AD). The present study aimed to examine the composition of erythrocyte phospholipids including pl-PE in patients with AD.
  
  
  METHODS
  A high-performance liquid chromatography (HPLC) method that can separate intact plasmalogens and all other phospholipid classes by a single chromatographic run was used.
  
  
  RESULTS
  The ratios of pl-PE, phosphatidylethanolamine (PE) and phosphatidylserine (PS) to sphingomyelin were low as compared to those of the age-matched controls.
  
  
  CONCLUSIONS
  These changes in erythrocyte phospholipids may reflect changes induced by oxidative stress, indicating the presence of high oxidative stress in the peripheral blood of AD patients.
authors.affiliation: Department of Neurology, Fukuoka University School of Medicine, Fukuoka, Japan.
authors.forename: Shinji
authors.initials: S
authors.lastname: Oma
authors.forename: Shiro
authors.initials: S
authors.lastname: Mawatari
authors.forename: Kazuyuki
authors.initials: K
authors.lastname: Saito
authors.forename: Chikako
authors.initials: C
authors.lastname: Wakana
authors.forename: Yoshio
authors.initials: Y
authors.lastname: Tsuboi
authors.forename: Tatsuo
authors.initials: T
authors.lastname: Yamada
authors.forename: Takehiko
authors.initials: T
authors.lastname: Fujino