title: A ubiquitin-binding rhomboid protease aimed at ERADication.
abstract: Proteins are degraded from the ER by endoplasmic reticulum-associated degradation (ERAD). In a recent issue of Molecular Cell, Fleig et al. (2012) describe a role for a ubiquitin-binding rhomboid protease, RHBDL4, in degradation of select ERAD substrates. These findings and the significance of rhomboids and other intramembrane proteases are discussed.
authors.affiliation: Laboratory of Protein Dynamics and Signaling, Center for Cancer Research, National Cancer Institute, 1050 Boyles Street, Frederick, MD 21701, USA. tsaiyien@mail.nih.gov
authors.forename: Yien Che
authors.initials: YC
authors.lastname: Tsai
authors.forename: Allan M
authors.initials: AM
authors.lastname: Weissman