title: Statins, glucocorticoids, and nonsteroidal anti-inflammatory drugs:  their influence on implant healing.
abstract: This article aimed at exploring the effects of common systemic medications used in the United States and their effects on periimplant bone healing. An electronic search for articles evaluating the influence of systemic medications on periimplant bone healing was conducted using the PubMed (MEDLINE) database. Statins, when administered locally or systemically, were found to increase bone formation and density. A reduction in bone turnover and bone-to-implant contact was observed in animal models examining the effect of glucocorticoids on periimplant bone healing. Continued use of nonsteroidal anti-inflammatory drugs (NSAIDs) during or after implant placement was associated with reduced bone-to-implant contact, bone area, and bone density. Evidence seems to suggest that statins improve implant osseointegration. However, glucocorticoids and NSAIDs showed conflicting results. Therefore, more randomized clinical trials are needed to validate the effect of glucocorticoids and NSAIDs on periimplant bone healing.
authors.affiliation: Department of Periodontics, Faculty of Dentistry, National University of Singapore, Singapore.
authors.forename: Jia-Hui
authors.initials: JH
authors.lastname: Fu
authors.forename: Jill D
authors.initials: JD
authors.lastname: Bashutski
authors.forename: Khalid
authors.initials: K
authors.lastname: Al-Hezaimi
authors.forename: Hom-Lay
authors.initials: HL
authors.lastname: Wang
mesh_terms: D000539:Alveolar Process / Q000187:drug effects; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology*; D015921:Dental Implants; D005938:Glucocorticoids / Q000494:pharmacology*; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000494:pharmacology*; D016348:Osseointegration / Q000187:drug effects*; D014945:Wound Healing / Q000187:drug effects
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D015921:Dental Implants; D005938:Glucocorticoids; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors