title: Azacitidine-induced pneumonitis in a patient with myelodysplastic syndrome: first case report in Japan.
abstract: A 74-year-old Japanese man with myelodysplastic syndrome (MDS) received chemotherapy with azacitidine. From the second day after starting the administration, he complained of fever, cough and shortness of breath. Chest roentgenography and computed tomography showed consolidations and ground-glass opacities. His symptoms grew from worse to life-threatening. We diagnosed him with azacitidine-induced pneumonitis and began administering corticosteroids. Thereafter, his symptoms and radiographic abnormalities improved. Azacitidine is a hypomethylating agent that improves the survival of MDS patients. Although this drug is commonly well tolerated and rarely causes severe lung injury, it is important to consider the potentially serious adverse effects of azacitidine-induced pneumonitis.
authors.affiliation: Department of Respiratory Medicine, Showa University Fujigaoka Hospital, Japan.
authors.forename: Makoto
authors.initials: M
authors.lastname: Hayashi
authors.forename: Hiromi
authors.initials: H
authors.lastname: Takayasu
authors.forename: Mami
authors.initials: M
authors.lastname: Tada
authors.forename: Yohei
authors.initials: Y
authors.lastname: Yamazaki
authors.forename: Hidetsugu
authors.initials: H
authors.lastname: Tateno
authors.forename: Sakiko
authors.initials: S
authors.lastname: Tazawa
authors.forename: Aya
authors.initials: A
authors.lastname: Wakabayashi
authors.forename: Takuya
authors.initials: T
authors.lastname: Iwasaki
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Tsuchiya
authors.forename: Jun
authors.initials: J
authors.lastname: Yamashita
authors.forename: Norikazu
authors.initials: N
authors.lastname: Takeda
authors.forename: Shogo
authors.initials: S
authors.lastname: Tomita
authors.forename: Hiraku
authors.initials: H
authors.lastname: Mori
authors.forename: Fumio
authors.initials: F
authors.lastname: Kokubu
mesh_terms: D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D000368:Aged; D000964:Antimetabolites, Antineoplastic / Q000009:adverse effects / Q000627:therapeutic use; D001374:Azacitidine / Q000009:adverse effects* / Q000627:therapeutic use*; D006801:Humans; D007564:Japan; D008297:Male; D009190:Myelodysplastic Syndromes / Q000188:drug therapy*; D011014:Pneumonia / Q000139:chemically induced* / Q000175:diagnosis / Q000188:drug therapy; D016896:Treatment Outcome
chemical_list: D000305:Adrenal Cortex Hormones; D000964:Antimetabolites, Antineoplastic; D001374:Azacitidine