title: Electrochemical determination of olmesartan medoxomil using hydrothermally prepared nanoparticles composed SnO2-Co3O4 nanocubes in tablet dosage forms.
abstract: Low-dimensional nanoparticles composed SnO(2)-Co(3)O(4) nanocubes (NCs) were prepared by a hydrothermal method using reducing agents. The doped nanomaterials were investigated by UV/vis, powder X-ray diffraction, FT-IR, energy-dispersive X-ray spectroscopy (EDS), and Raman spectroscopy, and field-emission scanning electron microscopy. They were deposited on a silver electrode (AgE, surface area, 0.0216 cm(2)) to give a drug sensor with a fast response towards Olmesartan medoxomil (OSM) in 0.1 mol L(-1) phosphate buffer-phases. The sensor also exhibits higher sensitivity, long-term stability, and enhanced electrochemical response. The calibration plot is linear (r(2)=0.9948) over the 0.28 nmol L(-1)-1.4 μM OSM concentration range. The sensitivity is ~2.083 μA cm(-2) mmol L(-1) and the detection limit is 0.17 nmol L(-1) (at an SNR of 3). We discuss the possible potential uses of this nanoparticles doped semiconductor NCs in terms of drug sensing, which could also be employed for the determination of drugs in quality control of formulation.
authors.affiliation: Center of Excellence for Advanced Materials Research (CEAMR), King Abdulaziz University, Jeddah 21589, P.O. Box 80203, Saudi Arabia. mmrahman@kau.edu.sa
authors.forename: Mohammed M
authors.initials: MM
authors.lastname: Rahman
authors.forename: Sher Bahadar
authors.initials: SB
authors.lastname: Khan
authors.forename: M
authors.initials: M
authors.lastname: Faisal
authors.forename: Malik Abdul
authors.initials: MA
authors.lastname: Rub
authors.forename: Abdulrahman O
authors.initials: AO
authors.lastname: Al-Youbi
authors.forename: Abdullah M
authors.initials: AM
authors.lastname: Asiri
mesh_terms: D003035:Cobalt / Q000737:chemistry*; D004563:Electrochemistry / Q000379:methods*; D007093:Imidazoles / Q000032:analysis* / Q000737:chemistry; D053758:Nanoparticles / Q000737:chemistry*; D000068557:Olmesartan Medoxomil; D055620:Optical Phenomena; D010087:Oxides / Q000737:chemistry*; D010710:Phosphates / Q000737:chemistry; D013607:Tablets; D013696:Temperature; D013777:Tetrazoles / Q000032:analysis* / Q000737:chemistry; D013997:Time Factors; D017971:Tin Compounds / Q000737:chemistry*
chemical_list: D007093:Imidazoles; D010087:Oxides; D010710:Phosphates; D013607:Tablets; D013777:Tetrazoles; D017971:Tin Compounds; D003035:Cobalt; D000068557:Olmesartan Medoxomil; C045358:stannic oxide; C060728:cobalt oxide