title: Comparative study on the histomorphology and molecular biology of radial artery conduits in patients with diabetes mellitus who underwent coronary bypass surgery.
abstract: We studied the impact of diabetes mellitus (DM) on the radial artery (RA) in 30 patients with DM and 30 non-diabetic patients undergoing coronary artery bypass grafting with autologous RA. RAs were recorded as normal if there was no cellular or stromal tissue between the endothelium and the internal elastic lamina. The RA was normal in 26.7% of diabetic and 76.7% of non-diabetic patients (p = 0.000298). Intimal thickness index and intima:media ratio were higher in the former than in the latter (p < 0.05; p < 0.05), with no significant difference in luminal narrowing (p > 0.05). Electron microscopy scores were lower in the non-diabetic group (p < 0.001); endothelial nitric oxide synthase (eNOS) protein expression and optical density were higher (p < 0.001). Von Willebrand factor and endothelin-1 messenger RNA (mRNA) levels were higher in the DM patients (p < 0.001). The quality of the RA in patients with DM was thus inferior to that in non-diabetic patients. Care should be taken when selecting RA as a conduit in patients with DM.
authors.affiliation: Department of Thoracic and Cardiovascular Surgery, Nanjing First Hospital Affiliated to Nanjing Medical University, Nanjing, People's Republic of China.
authors.forename: Liang
authors.initials: L
authors.lastname: Zou
authors.forename: Xujun
authors.initials: X
authors.lastname: Chen
authors.forename: Wen
authors.initials: W
authors.lastname: Chen
authors.forename: Li
authors.initials: L
authors.lastname: Li
authors.forename: Fuhua
authors.initials: F
authors.lastname: Huang
authors.forename: Fei
authors.initials: F
authors.lastname: Xiang
authors.forename: Xin
authors.initials: X
authors.lastname: Chen
mesh_terms: D000368:Aged; D059168:Carotid Intima-Media Thickness; D016893:Carotid Stenosis / Q000209:etiology / Q000517:prevention & control; D001026:Coronary Artery Bypass; D003324:Coronary Artery Disease / Q000150:complications / Q000378:metabolism / Q000473:pathology* / Q000601:surgery; D003925:Diabetic Angiopathies / Q000378:metabolism / Q000473:pathology* / Q000601:surgery; D019332:Endothelin-1 / Q000096:biosynthesis* / Q000235:genetics / Q000378:metabolism; D004730:Endothelium, Vascular / Q000201:enzymology / Q000378:metabolism / Q000648:ultrastructure; D005260:Female; D006801:Humans; D006965:Hyperplasia; D008297:Male; D046529:Microscopy, Electron, Transmission; D008875:Middle Aged; D052250:Nitric Oxide Synthase Type III / Q000378:metabolism*; D012333:RNA, Messenger / Q000378:metabolism; D017534:Radial Artery / Q000378:metabolism / Q000601:surgery / Q000648:ultrastructure*; D014182:Transplantation, Autologous; D015854:Up-Regulation; D014841:von Willebrand Factor / Q000096:biosynthesis* / Q000235:genetics / Q000378:metabolism
chemical_list: D019332:Endothelin-1; D012333:RNA, Messenger; D014841:von Willebrand Factor; C496314:NOS3 protein, human; D052250:Nitric Oxide Synthase Type III