title: Relief with rapamycin: mTOR inhibition protects against radiation-induced mucositis.
abstract: In this issue of Cell Stem Cell, Iglesias-Bartolome et al. (2012) show that mTOR inhibition with rapamycin protects against mucositis in mice, suggesting potential treatment strategies against this harmful side effect of anticancer therapies. In normal tissues, rapamycin prevents epithelial stem cell senescence by reducing oxidative stress through increased MnSOD.
authors.affiliation: Center for Molecular Medicine, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA. finkelt@nih.gov
authors.forename: Toren
authors.initials: T
authors.lastname: Finkel
mesh_terms: D000818:Animals; D016922:Cellular Senescence; D019610:Cytoprotection; D004847:Epithelial Cells / Q000473:pathology*; D006801:Humans; D052016:Mucositis / Q000517:prevention & control*; D011832:Radiation Injuries / Q000517:prevention & control*; D013234:Stem Cells / Q000473:pathology*; D058570:TOR Serine-Threonine Kinases / Q000037:antagonists & inhibitors*
chemical_list: C546842:MTOR protein, human; D058570:TOR Serine-Threonine Kinases