title: miR-518b is down-regulated, and involved in cell proliferation and invasion by targeting Rap1b in esophageal squamous cell carcinoma.
abstract: MicroRNAs (miRNAs) represent a class of small non-coding RNAs that regulate gene expression at the post-transcriptional levels. Recent studies show that miRNAs may function as oncogenes or tumor suppressor genes. In this study, we demonstrated that miR-518b was down-regulated in esophageal squamous cell carcinoma (ESCC) tissues and correlated with metastasis and survival. miR-518b suppressed the proliferation by inducing apoptosis and repressed the invasion in ESCC cells, but had no effect on the cell cycle. Furthermore, Rap1b was revealed to be directly regulated by miR-518b. These findings indicate that miR-518b may function as a tumor suppressor by targeting Rap1b in the development of ESCC and has important clinical and prognostic value.
authors.affiliation: Department of Thoracic Oncosurgery, First Affiliated Hospital, Medical School, Xi'an Jiaotong University, Xi'an 710061, Shaanxi Province, China.
authors.forename: Mingxin
authors.initials: M
authors.lastname: Zhang
authors.forename: Suna
authors.initials: S
authors.lastname: Zhou
authors.forename: Lingmin
authors.initials: L
authors.lastname: Zhang
authors.forename: Jia
authors.initials: J
authors.lastname: Zhang
authors.forename: Hui
authors.initials: H
authors.lastname: Cai
authors.forename: Jinxiang
authors.initials: J
authors.lastname: Zhu
authors.forename: Chen
authors.initials: C
authors.lastname: Huang
authors.forename: Jiansheng
authors.initials: J
authors.lastname: Wang
mesh_terms: D000368:Aged; D017209:Apoptosis / Q000235:genetics; D001483:Base Sequence; D002294:Carcinoma, Squamous Cell / Q000235:genetics* / Q000378:metabolism / Q000473:pathology* / Q000556:secondary; D002453:Cell Cycle; D045744:Cell Line, Tumor; D049109:Cell Proliferation; D018572:Disease-Free Survival; D015536:Down-Regulation; D004938:Esophageal Neoplasms / Q000235:genetics* / Q000378:metabolism / Q000473:pathology*; D005260:Female; D006801:Humans; D008297:Male; D035683:MicroRNAs / Q000037:antagonists & inhibitors / Q000235:genetics* / Q000378:metabolism; D008875:Middle Aged; D009361:Neoplasm Invasiveness / Q000235:genetics; D012334:RNA, Neoplasm / Q000235:genetics / Q000378:metabolism; D020668:rap GTP-Binding Proteins / Q000235:genetics / Q000378:metabolism*
chemical_list: C571457:MIRN518 microRNA, human; D035683:MicroRNAs; D012334:RNA, Neoplasm; C116753:RAP1B protein, human; D020668:rap GTP-Binding Proteins