title: Morphofunctional changes in the kidneys in chronic endotoxemia against the background of hypothyroidism.
abstract: We studied morphological structure of the kidneys in chronic endotoxemia modeled against the background of hypothyroidism. The detected changes did not differ from those under conditions of basic endotoxemia model and were characterized by the development of glomerulosclerosis and glomerulohyalinosis. The changes were less severe in rats with hypothyroidism and appeared at the late terms of the experiment. This indicated a moderate protective effect of preexisting thyroid hormone deficiency.
authors.affiliation: Volgograd State Medical University, Ministry of Health and Social Development of the Russian Federation, Moscow, Russia. Kalashnikova-SA@yandex.ru
authors.forename: S A
authors.initials: SA
authors.lastname: Kalashnikova
authors.forename: G A
authors.initials: GA
authors.lastname: Kovnatskaya
authors.forename: A I
authors.initials: AI
authors.lastname: Shchyogolev
mesh_terms: D000818:Animals; D019446:Endotoxemia / Q000150:complications / Q000473:pathology* / Q000503:physiopathology*; D004797:Enzyme-Linked Immunosorbent Assay; D007037:Hypothyroidism / Q000150:complications*; D007668:Kidney / Q000473:pathology* / Q000503:physiopathology*; D008297:Male; D051381:Rats; D013972:Thyrotropin / Q000097:blood; D013974:Thyroxine / Q000097:blood; D014284:Triiodothyronine / Q000097:blood
chemical_list: D014284:Triiodothyronine; D013972:Thyrotropin; D013974:Thyroxine