title: Impact of olive oil phenolic concentration on human plasmatic phenolic metabolites.
abstract: Three different functional phenol-enriched virgin olive oils (FVOO) were prepared with a phenolic content of 250 (L-FVOO), 500 (M-FVOO), and 750 mg (H-FVOO) total phenols/kg. In a randomised, cross-over study with 12 healthy volunteers, the pharmacokinetics of phenolic biological metabolites was assessed. An increasing linear trend was observed for hydroxytyrosol sulfate, the main phenolic metabolite quantified in plasma, with C(max) values of 1.35, 3.32, and 4.09 μmol/l, and AUC mean values of 263.7, 581.4, and 724.4 μmol/min for L-FVOO, M-FVOO, and H-FVOO, respectively. From our data an acute intake of phenol-enriched olive oils promotes a dose-dependent response of phenol conjugate metabolites in human plasma. Also, we point out for the first time hydroxytyrosol acetate sulfate as a main biological metabolite of hydroxytyrosol from olive oil ingestion.
authors.affiliation: Food Technology Department, XaRTA-TPV, Escuela Técnica Superior de Ingeniería Agraria, University of Lleida, Av/Alcalde Rovira Roure 191, 25198 Lleida, Spain.
authors.forename: Laura
authors.initials: L
authors.lastname: Rubió
authors.forename: Rosa-M
authors.initials: RM
authors.lastname: Valls
authors.forename: Alba
authors.initials: A
authors.lastname: Macià
authors.forename: Anna
authors.initials: A
authors.lastname: Pedret
authors.forename: Montse
authors.initials: M
authors.lastname: Giralt
authors.forename: Maria-Paz
authors.initials: MP
authors.lastname: Romero
authors.forename: Rafael
authors.initials: R
authors.lastname: de la Torre
authors.forename: Maria-Isabel
authors.initials: MI
authors.lastname: Covas
authors.forename: Rosa
authors.initials: R
authors.lastname: Solà
authors.forename: Maria-José
authors.initials: MJ
authors.lastname: Motilva
mesh_terms: D000328:Adult; D000975:Antioxidants / Q000032:analysis / Q000378:metabolism; D018592:Cross-Over Studies; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D000069463:Olive Oil; D010636:Phenols / Q000097:blood* / Q000493:pharmacokinetics; D010938:Plant Oils / Q000737:chemistry / Q000378:metabolism*; D055815:Young Adult
chemical_list: D000975:Antioxidants; D000069463:Olive Oil; D010636:Phenols; D010938:Plant Oils