title: Simple and effective large-scale preparation of geniposide from fruit of Gardenia jasminoides Ellis using a liquid-liquid two-phase extraction.
abstract: Geniposide was prepared on a large-scale using a selective two-phase liquid-liquid extraction. The aqueous residue from the fruit of Gardenia jasminoides Ellis was treated with sodium carbonate and extracted with n-butanol several times. The n-butanol extracts were treated with activated granular charcoal to remove pigments and were then concentrated to produce a residue with a high solid content. The residue was crystallized to obtain geniposide with 98% purity. For large-scale synthesis, the residue (solid content 45%, geniposide 5.5%) was extracted to generate 70g of geniposide with 98% purity and 84.8% recovery using 1500g residue.
authors.affiliation: Department of Chemistry, Guangxi University, Nanning, 530004, PR China.
authors.forename: Min
authors.initials: M
authors.lastname: Zhou
authors.forename: Jiaxiong
authors.initials: J
authors.lastname: Zhuo
authors.forename: Wanxing
authors.initials: W
authors.lastname: Wei
authors.forename: Jianwen
authors.initials: J
authors.lastname: Zhu
authors.forename: Xiurong
authors.initials: X
authors.lastname: Ling
mesh_terms: D000440:Butanols; D005638:Fruit / Q000737:chemistry*; D032062:Gardenia / Q000737:chemistry*; D006863:Hydrogen-Ion Concentration; D039823:Iridoids / Q000737:chemistry*; D059625:Liquid-Liquid Extraction; D015394:Molecular Structure
chemical_list: D000440:Butanols; D039823:Iridoids; C007835:geniposide