title: Endogenous regulators of NO bioavailability in rats with acute renal failure.
abstract: We studied the impact of acute glycerol-induced renal failure on blood levels and daily urinary excretion of arginine, monomethylarginine, and asymmetric and symmetric dimethylarginine. Acute renal failure was accompanied by enhanced daily excretion of asymmetric and symmetric dimethylarginine, increased plasma level of symmetric dimethylarginine, and decreased plasma level of arginine. Reabsorption of arginine and its methylated analogues decreased, thus compensating for reduced glomerular filtration rate. These data attest to increased production of dimethylarginines during acute renal failure. These changes can decrease NO bioavailability.
authors.affiliation: Laboratory for the Regulation of Adaptation Processes, Institute of Physiology, Siberian Division of the Russian Academy of Medical Sciences, Novosibirsk, Russia. suhovershin@physiol.ru
authors.forename: R A
authors.initials: RA
authors.lastname: Sukhovershin
authors.forename: M A
authors.initials: MA
authors.lastname: Gilinsky
mesh_terms: D058186:Acute Kidney Injury / Q000097:blood* / Q000139:chemically induced / Q000652:urine*; D000704:Analysis of Variance; D000818:Animals; D001120:Arginine / Q000031:analogs & derivatives / Q000097:blood / Q000378:metabolism* / Q000652:urine; D001682:Biological Availability; D002851:Chromatography, High Pressure Liquid; D016000:Cluster Analysis; D005990:Glycerol / Q000008:administration & dosage / Q000633:toxicity; D007273:Injections, Intramuscular; D008297:Male; D009569:Nitric Oxide / Q000493:pharmacokinetics*; D051381:Rats; D017208:Rats, Wistar; D018709:Statistics, Nonparametric
chemical_list: C487735:dimethylarginine; D009569:Nitric Oxide; D001120:Arginine; D005990:Glycerol