title: Evaluation of histopathological changes in control biopsies which taken 48 sessions after NBUVB phototherapy for early-stage mycosis fungoides.
abstract: BACKGROUND
  There are not many studies investigating histomorphological changes in 48 sessions in patients with early-stage MF after narrowband UVB (NBUVB) treatment. Our purpose is to evaluate histological features of phototherapy after 48 sessions and determine which parameters are more reliable for controlling skin biopsies.
  
  
  METHODS
  Biopsies of 32 patients with early stage of MF, who were treated with NBUVB phototherapy, were histologically evaluated before and after the treatments, including epidermotropism, stratum corneum, epidermal thickness, dermal infiltration, papillary dermal fibrosis, vascular alterations, and other dermal changes. We discuss the histomorphological effects of NBUVB phototherapy on skin biopsies by comparing the responders with nonresponders, with before and after the treatment.
  
  
  RESULTS
  9 patients (28%) did not give any response to treatment. Alleviation in epidermotropism, increases in parakeratosis and normal keratosis, perivascular infiltration, and melanophages, decrease in the lichenoid/patchy lichenoid infiltration pattern after the treatment was statistically significant. Comparing by response, normalization of stratum corneum and epidermis, orthohyperkeratosis, decrease in linearly arranged cells, the lichenoid/patchy lichenoid infiltration, the loss of inflammation were statistically significant in responders group.
  
  
  CONCLUSIONS
  We detected a significant decrease in linearly arranged cells after phototherapy, indicating that it is an "important diagnostic parameter" in evaluation of therapeutic response.
authors.affiliation: Department of Pathology, Training and Research Hospital, Istanbul Medeniyet University, SB Goztepe, Turkey. ebruzemheri@gmail.com
authors.forename: Ebru
authors.initials: E
authors.lastname: Zemheri
authors.forename: Seyma
authors.initials: S
authors.lastname: Ozkanli
authors.forename: Ilkin
authors.initials: I
authors.lastname: Zindanci
authors.forename: Serkan
authors.initials: S
authors.lastname: Senol
authors.forename: Ozge
authors.initials: O
authors.lastname: Akbulak
authors.forename: Elvan
authors.initials: E
authors.lastname: Turfanda
authors.forename: Mehtap
authors.initials: M
authors.lastname: Toprak
authors.forename: Duygu
authors.initials: D
authors.lastname: Kosemetin
authors.forename: Abdullah
authors.initials: A
authors.lastname: Aydin
mesh_terms: D000328:Adult; D000368:Aged; D001706:Biopsy / Q000379:methods; D004817:Epidermis / Q000473:pathology; D005260:Female; D006801:Humans; D006965:Hyperplasia / Q000473:pathology; D007249:Inflammation / Q000473:pathology / Q000628:therapy; D007642:Keratosis / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009182:Mycosis Fungoides / Q000473:pathology* / Q000628:therapy*; D009367:Neoplasm Staging; D010241:Parakeratosis / Q000473:pathology; D012680:Sensitivity and Specificity; D012867:Skin / Q000473:pathology*; D012878:Skin Neoplasms / Q000473:pathology / Q000628:therapy; D013684:Telangiectasis / Q000473:pathology; D016896:Treatment Outcome; D014467:Ultraviolet Therapy / Q000379:methods*