title: Comparative study on the inhibitory effects of α-tocopherol and radon on carbon tetrachloride-induced renal damage.
abstract: Since the 2011 nuclear accident in Fukushima, the effects of low-dose irradiation, especially internal exposure, are at the forefront of everyone's attention. However, low-dose radiation induced various stimulating effects such as activation of antioxidative and immune functions. In this study, we attempted to evaluate the quantitative effects of the activation of antioxidative activities in kidney induced by radon inhalation on carbon tetrachloride (CCl4)-induced renal damage. Mice were subjected to intraperitoneal (i.p.) injection of CCl4 after inhaling approximately 1000 or 2000 Bq/m3 radon for 24 h, or immediately after i.p. injection of α-tocopherol (100, 300, or 500 mg/kg bodyweight). In case of renal function, radon inhalation at a concentration of 2000 Bq/m3 has the inhibitory effects similar to α-tocopherol treatment at a dose of 300-500 mg/kg bodyweight. The activities of superoxide dismutase and catalase in kidneys were significantly higher in mice exposed to radon as compared to mice treated with CCl4 alone. These findings suggest that radon inhalation has an antioxidative effect against CCl4-induced renal damage similar to the antioxidative effects of α-tocopherol due to induction of antioxidative functions.
authors.affiliation: Graduate School of Health Sciences, Okayama University, Okayama, Japan.
authors.forename: Takahiro
authors.initials: T
authors.lastname: Kataoka
authors.forename: Keiko
authors.initials: K
authors.lastname: Yamato
authors.forename: Yuichi
authors.initials: Y
authors.lastname: Nishiyama
authors.forename: Yuji
authors.initials: Y
authors.lastname: Morii
authors.forename: Reo
authors.initials: R
authors.lastname: Etani
authors.forename: Yuji
authors.initials: Y
authors.lastname: Takata
authors.forename: Katsumi
authors.initials: K
authors.lastname: Hanamoto
authors.forename: Atsuishi
authors.initials: A
authors.lastname: Kawabe
authors.forename: Akihiro
authors.initials: A
authors.lastname: Sakoda
authors.forename: Yuu
authors.initials: Y
authors.lastname: Ishimori
authors.forename: Takehito
authors.initials: T
authors.lastname: Taguchi
authors.forename: Kiyonori
authors.initials: K
authors.lastname: Yamaoka
mesh_terms: D058186:Acute Kidney Injury / Q000209:etiology / Q000473:pathology / Q000517:prevention & control*; D000818:Animals; D000975:Antioxidants / Q000627:therapeutic use; D002251:Carbon Tetrachloride / Q000633:toxicity; D002252:Carbon Tetrachloride Poisoning / Q000150:complications* / Q000188:drug therapy / Q000473:pathology; D004195:Disease Models, Animal; D005260:Female; D005919:Glomerular Filtration Rate / Q000187:drug effects; D007668:Kidney / Q000187:drug effects / Q000473:pathology* / Q000503:physiopathology; D051379:Mice; D008813:Mice, Inbred ICR; D011886:Radon / Q000627:therapeutic use*; D016896:Treatment Outcome; D024502:alpha-Tocopherol / Q000627:therapeutic use*
chemical_list: D000975:Antioxidants; D002251:Carbon Tetrachloride; D024502:alpha-Tocopherol; D011886:Radon