title: Extracorporeal life support in patients with severe trauma: an advanced treatment strategy for refractory clinical settings.
abstract: OBJECTIVE
  Major trauma is a leading cause of death, particularly among young patients. New strategies in management are needed to improve poor outcomes in cases of severe trauma. Extracorporeal life support (ECLS) has proven to be effective in acute cardiopulmonary failure of different causes, even when conventional therapies fail. We report our initial experience with ECLS as a rescue therapy in severely polytraumatized patients in a refractory clinical setting. This study identifies the pre-ECLS characteristics of patients to predict the appropriateness of ECLS treatment.
  
  
  METHODS
  From December 2008 to May 2012, 375 patients with polytrauma were treated in the Careggi Teaching Hospital, a tertiary-level referral trauma center. Our ECLS team was alerted on 30 patients and applied ECLS in 18 adult patients with trauma. We adopted venoarterial ECLS in 14 patients with cardiopulmonary failure with refractory shock and venovenous ECLS in 4 patients with isolated refractory acute respiratory failure.
  
  
  RESULTS
  ECLS was initiated at a mean of 359.176 ± 216.606 (145-950) minutes from trauma. In 4 patients, the ECLS treatment failed because of an incapability to maintain adequate ECLS flow and perfusion. In 14 patients, efficiently supported by ECLS, the cardiac index, mean arterial pressure, blood lactate concentration, arterial oxygen tension, arterial carbon dioxide tension, and pH showed significant improvement, with normal values reached at 3.5 ± 1.5 hours.
  
  
  CONCLUSIONS
  From our data, ECLS seems to be a valuable option to resuscitate patients with severe trauma when conventional therapies are insufficient. ECLS is safe, feasible, and effective in providing hemodynamic support and blood gas exchange.
authors.affiliation: Medical and Surgical Critical Care Department, Cardiac Surgery, University of Florence, Florence, Italy. massimo.bonacchi@unifi.it
authors.forename: Massimo
authors.initials: M
authors.lastname: Bonacchi
authors.forename: Rosario
authors.initials: R
authors.lastname: Spina
authors.forename: Leonardo
authors.initials: L
authors.lastname: Torracchi
authors.forename: Guy
authors.initials: G
authors.lastname: Harmelin
authors.forename: Guido
authors.initials: G
authors.lastname: Sani
authors.forename: Adriano
authors.initials: A
authors.lastname: Peris
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D005112:Extracorporeal Circulation; D005260:Female; D005440:Fluid Therapy / Q000379:methods; D006801:Humans; D015601:Injury Severity Score; D008020:Life Support Care / Q000379:methods*; D008297:Male; D008875:Middle Aged; D009104:Multiple Trauma / Q000628:therapy*; D012372:ROC Curve; D014193:Trauma Centers; D016896:Treatment Outcome