title: Unusual pyrrolyl 4-quinolinone alkaloids from the marine-derived fungus Penicillium sp. ghq208.
abstract: One new pyrrolyl 4-quinolinone alkaloid, penicinoline E (1), together with three known deriverites, methyl-penicinoline (2), penicinoline (3), and quinolactacide (4), were isolated from the marine-derived fungus Penicillium sp. ghq208. The structures of these isolated compounds were elucidated by spectroscopic methods. Compounds (2, 3) exhibited moderate cytotoxicities against the HepG2 cell line with IC(50) values of 11.3 and 13.2 µM, respectively.
authors.affiliation: Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, P R China.
authors.forename: Huquan
authors.initials: H
authors.lastname: Gao
authors.forename: Lianqing
authors.initials: L
authors.lastname: Zhang
authors.forename: Tianjiao
authors.initials: T
authors.lastname: Zhu
authors.forename: Qianqun
authors.initials: Q
authors.lastname: Gu
authors.forename: Dehai
authors.initials: D
authors.lastname: Li
mesh_terms: D042462:4-Quinolones / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D000470:Alkaloids / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D000970:Antineoplastic Agents / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D002470:Cell Survival / Q000187:drug effects; D056945:Hep G2 Cells; D006801:Humans; D020128:Inhibitory Concentration 50; D008113:Liver Neoplasms / Q000188:drug therapy; D010407:Penicillium / Q000737:chemistry*; D011758:Pyrroles / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology
chemical_list: D042462:4-Quinolones; D000470:Alkaloids; D000970:Antineoplastic Agents; D011758:Pyrroles