title: Preparation of poly(methyl methacrylate) microcapsules by in situ polymerization on the surface of calcium carbonate particles.
abstract: Poly(methyl methacrylate) (PMMA) microcapsules were prepared by the in situ polymerization of methyl methacrylate (MMA) and N,N'-methylenebisacrylamide on the surface of calcium carbonate (CaCO(3)) particles, followed by the dissolution of the CaCO(3) core in ethylenediaminetetraacetic acid solution. The microcapsules were characterized using fluorescence microscopy, atomic force microscopy, scanning electron microscopy, and Fourier transform infrared spectroscopy. The average sizes of the CaCO(3) particles and PMMA capsules were 3.8±0.6 and 4.0±0.6 μm, respectively. A copolymer consisting of MMA and rhodamine B-bearing MMA was also used to prepare microcapsules for fluorescent microscopy observations. Fluorescein isothiocyanate-labeled bovine serum albumin was enclosed in the PMMA microcapsules and its release properties were studied.
authors.affiliation: Graduate School of Pharmaceutical Sciences, Tohoku University, Aramaki, Aoba-ku, Sendai 980-8578, Japan. satok@m.tohoku.ac.jp
authors.forename: Katsuhiko
authors.initials: K
authors.lastname: Sato
authors.forename: Tatsuya
authors.initials: T
authors.lastname: Nakajima
authors.forename: Jun-ichi
authors.initials: J
authors.lastname: Anzai
mesh_terms: D000818:Animals; D002119:Calcium Carbonate / Q000737:chemistry*; D002214:Capsules / Q000737:chemistry*; D002417:Cattle; D016650:Fluorescein-5-isothiocyanate / Q000008:administration & dosage / Q000031:analogs & derivatives*; D058105:Polymerization; D019904:Polymethyl Methacrylate / Q000737:chemistry*; D012710:Serum Albumin, Bovine / Q000008:administration & dosage*
chemical_list: D002214:Capsules; C039217:fluorescein isothiocyanate bovine serum albumin; D012710:Serum Albumin, Bovine; D019904:Polymethyl Methacrylate; D002119:Calcium Carbonate; D016650:Fluorescein-5-isothiocyanate