title: Meta-analysis of genetic association of chromosome 9p21 with early-onset coronary artery disease.
abstract: OBJECTIVE
  A number of studies reported on associations of single nucleotide polymorphisms (SNPs) present in chromosome 9p21 with early-onset coronary artery disease (CAD). The present study was then undertaken to perform a meta-analysis of all the results published to date.
  
  
  METHODS
  All studies of the 9p21 association with early-onset CAD that were published between 2007 and 2012 were retrieved from the PubMed database. RevMan 5.0 software was used to perform meta-analysis of the data that fulfilled the criteria for our meta-analysis. The effect size of four SNPs in the 9p21 region on early-onset CAD risk was assessed based on the odds ratios (ORs) with calculation of 95% confidence interval (CI).
  
  
  RESULTS
  A total of 7123 subjects from 7 case-control studies were genotyped. Meta-analysis demonstrated disease association for rs2383207 (OR=0.79, 95% CI 0.71-0.88, P<0.0001), rs2383206 (OR=1.17, 95% CI 1.10-1.25, P<0.00001), rs10757278 (OR=1.28, 95% CI 1.15-1.42, P<0.00001), and rs10757274 (OR=1.17, 95% CI 1.08-1.33, P=0.02).
  
  
  CONCLUSIONS
  Genetic variation in the chromosome 9p21 region may contribute to the etiology of early-onset CAD although their effect size is rather small.
authors.affiliation: Department of Occupational and Environmental Health, School of Public Health, Jilin University, Changchun, China.
authors.forename: Li-Ting
authors.initials: LT
authors.lastname: Zhou
authors.forename: Ling
authors.initials: L
authors.lastname: Qin
authors.forename: Dong-Chun
authors.initials: DC
authors.lastname: Zheng
authors.forename: Zi-Kai
authors.initials: ZK
authors.lastname: Song
authors.forename: Lin
authors.initials: L
authors.lastname: Ye
mesh_terms: D016022:Case-Control Studies; D002899:Chromosomes, Human, Pair 9; D003324:Coronary Artery Disease / Q000235:genetics*; D055106:Genome-Wide Association Study; D006801:Humans; D016017:Odds Ratio