title: Estradiol supplementation in intracytoplasmic sperm injection cycles with thin endometrium.
abstract: OBJECTIVE
  To evaluate the efficacy of estradiol supplementation starting on the day of human chorionic gonadotrophin (hCG) in patients with thin endometrium in intracytoplasmic sperm injection (ICSI) cycles.
  
  
  METHODS
  A total of 117 consecutive patients with the endometrial thickness on the hCG day ≤ 8 mm were reviewed. Estradiol supplementation was given in 57 patients and the remaining 60 patients were accepted as control group. Estradiol supplemented (ES) group received estradiol hemihydrate 4 mg/day started on the day of hCG. Luteal phase was supported using the vaginal progesterone gel in both groups. Clinical pregnancy rate, implantation rate, miscarriage rate, endometrial thickness on the day of oocyte pick-up and on the day of embryo transferred were accepted as main outcome measures.
  
  
  RESULTS
  There were no statistical differences in terms of clinical pregnancy rate (28.1% vs. 23.3%), implantation rate (16% vs. 10.4%), miscarriage rate (21% vs. 31.6%), endometrial thickness on the oocyte pick-up day (8.5 ± 1.8 vs. 8.4 ± 1.4, mm) and embryo transferred day (9.6 ± 2.9 vs. 10.3 ± 2.4, mm) in the ES group vs. control group.
  
  
  CONCLUSIONS
  Estradiol supplementation starting on the hCG day for the patients with thin endometrium does not provide any benefit on the pregnancy outcome in ICSI cycles.
authors.affiliation: Department of IVF, Etlik Zubeyde Hanım Women's Health Teaching and Research Hospital, Ankara, Turkey.
authors.forename: Berfu
authors.initials: B
authors.lastname: Demir
authors.forename: Serdar
authors.initials: S
authors.lastname: Dilbaz
authors.forename: Ozgur
authors.initials: O
authors.lastname: Cinar
authors.forename: Ozlem
authors.initials: O
authors.lastname: Ozdegirmenci
authors.forename: Suat
authors.initials: S
authors.lastname: Dede
authors.forename: Betul
authors.initials: B
authors.lastname: Dundar
authors.forename: Umit
authors.initials: U
authors.lastname: Goktolga
mesh_terms: D000022:Abortion, Spontaneous / Q000517:prevention & control; D000328:Adult; D006063:Chorionic Gonadotropin / Q000008:administration & dosage; D016208:Databases, Factual; D010064:Embryo Implantation / Q000187:drug effects; D004717:Endometrium / Q000187:drug effects / Q000473:pathology*; D004958:Estradiol / Q000008:administration & dosage*; D004967:Estrogens / Q000008:administration & dosage; D005260:Female; D005307:Fertilization in Vitro / Q000379:methods*; D006801:Humans; D007247:Infertility, Female / Q000188:drug therapy* / Q000473:pathology*; D008183:Luteal Phase / Q000187:drug effects; D011247:Pregnancy; D018873:Pregnancy Rate; D011374:Progesterone / Q000008:administration & dosage; D012189:Retrospective Studies; D020554:Sperm Injections, Intracytoplasmic / Q000379:methods*
chemical_list: D006063:Chorionic Gonadotropin; D004967:Estrogens; D011374:Progesterone; D004958:Estradiol