title: Lysophosphatidic acid: chemical signature of neuropathic pain.
abstract: Acute inflammatory pain signal originates from transient hypersensitivity in afferent fibers when depolarized via injured tissues or proinflammatory cells-derived pronociceptive ligand binding. This pain is sensitive to opioids and NSAIDs. In neuropathic pain, however, damage to the nerve along the pain pathway results in spontaneous generation of action potential and lowered nociceptive threshold, as seen in allodynia and hyperalgesia. This abnormal pain transmission had been linked to LPA production in the spinal cord, through activation of NMDA and NK1 activation by glutamate and SP in iPLA(2)/cPLA(2)/ATX-dependent pathway. In a bifurcated response involving G(q/11) and G(12/13) coupling, Schwann cell LPA(1) mediates degradation and transcriptional suppression of myelin proteins, respectively. The loss of contact inhibition on axonal growth creates cytoskeletal framework for axonal sprouting. LPA causes an amplification of LPA production through activation of LPA(3) signaling in microglia immediately after nerve injury. LPA(1) deficient mice (LPA(1)(-/-)) show no neuropathic-pain behavior or demyelination in response to intrathecal LPA injection or nerve injury. Given these bodies of research evidence, LPA therefore presents as the chemical signature for the initiation of neuropathic pain. This article is part of a Special Issue entitled Advances in Lysophospholipid Research.
authors.affiliation: Department of Molecular Pharmacology and Neuroscience, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan. ueda@nagasaki-u.ac.jp
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Ueda
authors.forename: Hayato
authors.initials: H
authors.lastname: Matsunaga
authors.forename: Omotuyi I
authors.initials: OI
authors.lastname: Olaposi
authors.forename: Jun
authors.initials: J
authors.lastname: Nagai
mesh_terms: D000818:Animals; D003711:Demyelinating Diseases / Q000235:genetics / Q000473:pathology; D006801:Humans; D008246:Lysophospholipids / Q000378:metabolism*; D008954:Models, Biological; D009437:Neuralgia / Q000378:metabolism* / Q000473:pathology; D009474:Neurons / Q000378:metabolism / Q000473:pathology; D015398:Signal Transduction
chemical_list: D008246:Lysophospholipids; C032881:lysophosphatidic acid