title: A case of Lambert-Eaton myasthenic syndrome with possible myasthenia gravis.
abstract: Lambert-Eaton myasthenic syndrome (LEMS) is a rare autoimmune disorder of neuromuscular transmission (NMJ) that shares many clinical features with myasthenia gravis (MG). We report a 73 year-old lady who presented 10 years previously with stiffness of both calves, dry mouth, fatigue, proximal weakness and areflexia in lower limbs. Neurophysiological studies were consistent with LEMS. Her work up for an underlying neoplasm was negative. She recently developed unilateral ptosis and diplopia which dramatically improved with pyridostigmine suggesting concomitant MG.
authors.affiliation: Department of Neurology, St James's Hospital, James's St, Dublin 8. mudassir213@hotmail.com
authors.forename: M
authors.initials: M
authors.lastname: Iqbal
authors.forename: S
authors.initials: S
authors.lastname: Connolly
authors.forename: Y
authors.initials: Y
authors.lastname: Langan
authors.forename: J
authors.initials: J
authors.lastname: Redmond
mesh_terms: D000200:Action Potentials; D000368:Aged; D002800:Cholinesterase Inhibitors / Q000627:therapeutic use; D015897:Comorbidity; D005260:Female; D006801:Humans; D015624:Lambert-Eaton Myasthenic Syndrome / Q000453:epidemiology* / Q000503:physiopathology; D009157:Myasthenia Gravis / Q000188:drug therapy / Q000453:epidemiology*; D011729:Pyridostigmine Bromide / Q000627:therapeutic use
chemical_list: D002800:Cholinesterase Inhibitors; D011729:Pyridostigmine Bromide