title: Physiological effects and tissue distribution from large doses of tocotrienol in rats.
abstract: Supplementation to an AIN93G-based diet of tocotrienol (T3) for 13 weeks administered to Fischer 344/slc rats showed a safety profile with no side effects. Dose-dependent T3 levels were detected in many tissues. Under the present experimental conditions, a continuous intake of the T3 concentrate would be safe in the rats as long as the T3 content was less than 0.20% of the dietary intake.
authors.affiliation: Food and Biodynamic Chemistry Laboratory, Graduate School of Agricultural Science, Tohoku University, Sendai 981-8555, Japan.
authors.forename: Akira
authors.initials: A
authors.lastname: Shibata
authors.forename: Kiyotaka
authors.initials: K
authors.lastname: Nakagawa
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Shirakawa
authors.forename: Teiko
authors.initials: T
authors.lastname: Kobayashi
authors.forename: Yuki
authors.initials: Y
authors.lastname: Kawakami
authors.forename: Rie
authors.initials: R
authors.lastname: Takashima
authors.forename: Ai
authors.initials: A
authors.lastname: Ohashi
authors.forename: Shoko
authors.initials: S
authors.lastname: Sato
authors.forename: Yusuke
authors.initials: Y
authors.lastname: Ohsaki
authors.forename: Fumiko
authors.initials: F
authors.lastname: Kimura
authors.forename: Toshiyuki
authors.initials: T
authors.lastname: Kimura
authors.forename: Tsuyoshi
authors.initials: T
authors.lastname: Tsuduki
authors.forename: Michio
authors.initials: M
authors.lastname: Komai
authors.forename: Teruo
authors.initials: T
authors.lastname: Miyazawa
mesh_terms: D000818:Animals; D001835:Body Weight / Q000187:drug effects; D004032:Diet; D019587:Dietary Supplements; D004334:Drug Administration Schedule; D008297:Male; D051381:Rats; D011916:Rats, Inbred F344; D014018:Tissue Distribution; D024508:Tocotrienols / Q000008:administration & dosage / Q000493:pharmacokinetics*; D014810:Vitamin E / Q000008:administration & dosage / Q000493:pharmacokinetics*
chemical_list: D024508:Tocotrienols; D014810:Vitamin E