title: Hepatic portal venous gas associated with severe graft-versus-host disease of the gastrointestinal tract.
abstract: We report a 67-year-old woman who was diagnosed with hepatic portal venous gas associated with severe graft-versus-host disease (GVHD) of the gastrointestinal tract. The patient received allogenic peripheral blood stem cell transplantation from a haploidentical son against Philadelphia chromosome-positive acute lymphocytic leukemia. The patient developed grade 3 intestinal GVHD on day 90 from the transplantation. On day 149, she presented septic shock and computed tomography (CT) scan revealed hepatic portal venous gas (HPVG); an ileocecal resection was performed immediately. The damage of gastrointestinal mucosa by GVHD resulted in the invasion of gas-producing bacteria. Although HPVG-associated gastrointestinal GVHD is extremely rare, we should pay special attention to this pathogenesis.
authors.affiliation: Department of Hematology, Yamagata Prefectural Central Hospital, Japan.
authors.forename: Junichiro
authors.initials: J
authors.lastname: Yuda
authors.forename: Riko
authors.initials: R
authors.lastname: Honma
authors.forename: Gen
authors.initials: G
authors.lastname: Tamura
authors.forename: Eijiro
authors.initials: E
authors.lastname: Omoto
mesh_terms: D000368:Aged; D017209:Apoptosis; D002432:Cecum / Q000473:pathology / Q000601:surgery; D017809:Fatal Outcome; D005260:Female; D005740:Gases / Q000378:metabolism*; D005767:Gastrointestinal Diseases / Q000209:etiology / Q000276:immunology / Q000378:metabolism*; D041981:Gastrointestinal Tract / Q000276:immunology / Q000378:metabolism* / Q000382:microbiology; D006086:Graft vs Host Disease / Q000209:etiology / Q000276:immunology / Q000378:metabolism*; D006801:Humans; D007082:Ileum / Q000473:pathology / Q000601:surgery; D036102:Peripheral Blood Stem Cell Transplantation / Q000009:adverse effects; D011169:Portal Vein / Q000378:metabolism*; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000601:surgery; D012720:Severity of Illness Index
chemical_list: D005740:Gases