title: Ischemia modified albumin levels cannot predict stress induced ischemia shown by myocardial perfusion scintigraphy.
abstract: OBJECTIVE
  Ischemia modified albumin (IMA) is a new marker of ischemia which is used in especially emergency room. Aim of this study is showing the association of IMA with stress induced ischemia on Tc-99m 2-methoxyisobutyl-nitrate (MIBI) myocardial perfusion scintigraphy (MPS).
  
  
  METHODS
  56 patients (23 F, 33 M; 56.04 ± 8.45 years old) were included in our study. Stress-rest two days protocol Tc-99m MIBI MPS single photon emission tomography (SPECT) was performed to all patients. IMA levels from the blood samples which were taken before and after the treadmill test were measured. Thirty patients additionally underwent coronary angiography.
  
  
  RESULTS
  The difference of IMA levels of ischemia between positive and negative groups was not statistically significant. Also, there was not statistically significant difference between IMA levels of patients who have narrowing in the coronary arteries and not.
  
  
  CONCLUSIONS
  Although IMA is an important marker of ischemia, probably because of other ischemic process during stress; it cannot reflect stress induced ischemic changes on MPS.
authors.affiliation: Nuclear Medicine Department, Firat University Medical Faculty, Elazig, Turkey. zehrapinarkoc@gmail.com
authors.forename: Z P
authors.initials: ZP
authors.lastname: Koc
authors.forename: M
authors.initials: M
authors.lastname: Erkilic
authors.forename: I
authors.initials: I
authors.lastname: Basarıcı
authors.forename: N
authors.initials: N
authors.lastname: Deger
authors.forename: S
authors.initials: S
authors.lastname: Ozdem
authors.forename: O
authors.initials: O
authors.lastname: Saka
mesh_terms: D015415:Biomarkers / Q000032:analysis / Q000097:blood / Q000378:metabolism; D003035:Cobalt / Q000378:metabolism; D003124:Colorimetry; D017023:Coronary Angiography; D023921:Coronary Stenosis / Q000097:blood / Q000000981:diagnostic imaging; D004630:Emergencies; D005080:Exercise Test; D005260:Female; D006439:Hemodynamics; D006801:Humans; D008297:Male; D008875:Middle Aged; D017202:Myocardial Ischemia / Q000097:blood / Q000000981:diagnostic imaging*; D055414:Myocardial Perfusion Imaging; D011446:Prospective Studies; D019275:Radiopharmaceuticals; D015203:Reproducibility of Results; D012709:Serum Albumin / Q000032:analysis* / Q000378:metabolism; D000075462:Serum Albumin, Human; D016037:Single-Blind Method; D017256:Technetium Tc 99m Sestamibi; D015899:Tomography, Emission-Computed, Single-Photon
chemical_list: D015415:Biomarkers; D019275:Radiopharmaceuticals; D012709:Serum Albumin; C561522:ischemia-modified albumin; D003035:Cobalt; D017256:Technetium Tc 99m Sestamibi; C018021:cobaltous chloride; D000075462:Serum Albumin, Human