title: An evaluation of polymorphisms in casein kinase 1 delta and epsilon genes in major psychiatric disorders.
abstract: Disturbances of the circadian rhythm are involved in the pathophysiology of bipolar disorder (BD), schizophrenia (SCZ) and major depressive disorder (MDD). Specifically, because clock gene dysfunction is good candidate for enhancing the susceptibility to these psychiatric disorders, we selected two circadian rhythm-related genes (CSNK1D and CSNK1E) and investigated genetic associations of the genes with these three disorders. None of the SNPs showed a significant association with MDD, but a SNP (rs2075984) in CSNK1E and SNP (rs6502097) in CSNK1D were associated with SCZ (P=0.0091, uncorrected) and BD (P=0.030, uncorrected), respectively. To confirm these findings, we analyzed an independent dataset (maximum N=3815) but found a lack of association (P=0.63 for rs2075984 and P=0.61 for rs6502097). The final meta-analysis showed no association between these SNPs with SCZ (P=0.21) and BD (P=0.53). These results do not support that genetic variation in CSNK1D and CSNK1E is a susceptibility factor for major psychiatric disorders in the Japanese population.
authors.affiliation: Department of Psychiatry, Fujita Health University School of Medicine, Toyoake, Aichi, Japan.
authors.forename: Shinji
authors.initials: S
authors.lastname: Matsunaga
authors.forename: Masashi
authors.initials: M
authors.lastname: Ikeda
authors.forename: Taro
authors.initials: T
authors.lastname: Kishi
authors.forename: Yasuhisa
authors.initials: Y
authors.lastname: Fukuo
authors.forename: Branko
authors.initials: B
authors.lastname: Aleksic
authors.forename: Reiji
authors.initials: R
authors.lastname: Yoshimura
authors.forename: Tomo
authors.initials: T
authors.lastname: Okochi
authors.forename: Yoshio
authors.initials: Y
authors.lastname: Yamanouchi
authors.forename: Yoko
authors.initials: Y
authors.lastname: Kinoshita
authors.forename: Kunihiro
authors.initials: K
authors.lastname: Kawashima
authors.forename: Wakako
authors.initials: W
authors.lastname: Umene-Nakano
authors.forename: Toshiya
authors.initials: T
authors.lastname: Inada
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Kunugi
authors.forename: Tadafumi
authors.initials: T
authors.lastname: Kato
authors.forename: Takeo
authors.initials: T
authors.lastname: Yoshikawa
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Ujike
authors.forename: Jun
authors.initials: J
authors.lastname: Nakamura
authors.forename: Norio
authors.initials: N
authors.lastname: Ozaki
authors.forename: Tsuyoshi
authors.initials: T
authors.lastname: Kitajima
authors.forename: Nakao
authors.initials: N
authors.lastname: Iwata
mesh_terms: D048149:Casein Kinase 1 epsilon / Q000235:genetics*; D048148:Casein Kinase Idelta / Q000235:genetics*; D005260:Female; D005819:Genetic Markers / Q000235:genetics; D020022:Genetic Predisposition to Disease / Q000453:epidemiology* / Q000235:genetics*; D006801:Humans; D007564:Japan / Q000453:epidemiology; D008297:Male; D001523:Mental Disorders / Q000453:epidemiology* / Q000235:genetics*; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D015995:Prevalence; D012307:Risk Factors
chemical_list: D005819:Genetic Markers; D048149:Casein Kinase 1 epsilon; D048148:Casein Kinase Idelta