title: Reduced expression of claudin-7 is associated with poor outcome in non-small cell lung cancer.
abstract: Claudin-7 is a tight junction protein that plays an important role in tumorigenesis, tumor invasion and metastasis. We examined the clinical significance of claudin-7 expression in 75 postsurgical non-small cell lung cancer (NSCLC) patients. Claudin-7 expression was measured immunohistochemically and was found to be high in 25 patients (33.3%) and low in 50 (66.7%). Survival was significantly poorer in patients with claudin-7-low than in those with claudin-7-high NSCLCs (P=0.024). In particular, survival was significantly poorer in patients with claudin-7-low than in those with claudin-7-high squamous cell carcinomas (P=0.011). A reduced expression of claudin-7 was associated with poor outcome in NSCLCs. Claudin-7 may thus be a useful biomarker and a potential therapeutic target in patients with NSCLC.
authors.affiliation: Department of Surgery, Yokohama City University, Kanagawa 236-0004.
authors.forename: Taketsugu
authors.initials: T
authors.lastname: Yamamoto
authors.forename: Takashi
authors.initials: T
authors.lastname: Oshima
authors.forename: Kazue
authors.initials: K
authors.lastname: Yoshihara
authors.forename: Sumitaka
authors.initials: S
authors.lastname: Yamanaka
authors.forename: Teppei
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authors.lastname: Nishii
authors.forename: Hiromasa
authors.initials: H
authors.lastname: Arai
authors.forename: Kenji
authors.initials: K
authors.lastname: Inui
authors.forename: Takeshi
authors.initials: T
authors.lastname: Kaneko
authors.forename: Akinori
authors.initials: A
authors.lastname: Nozawa
authors.forename: Tetsukan
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authors.lastname: Woo
authors.forename: Yasushi
authors.initials: Y
authors.lastname: Rino
authors.forename: Munetaka
authors.initials: M
authors.lastname: Masuda
authors.forename: Toshio
authors.initials: T
authors.lastname: Imada