title: New-onset diabetes mellitus: predictive factors and impact on the outcome of patients undergoing liver transplantation.
abstract: Liver transplantation (LT) for hepatocellular carcinoma (HCC) is the treatment of choice for patients with tumor characteristics within the Milan criteria associated with Child B or C cirrhosis. LT provides the best cure for both the tumor and the cirrhosis. There have been several emerging reports that new-onset diabetes mellitus (NODM) after transplantation (NODAT) is one of the most negative predictive factors for low survival rate and related co-morbidities. Little is known about the onset of NODM in post-transplant patients and, overall, whether the pathogenesis of NODM differs from that known for the general population. Principally, it is still unknown whether NODAT is related to the primary hepatic disease, the surgical procedures, immunosuppressive treatments, or is it due to the donor liver. This review will focus on the identification of factors, in the setting of LT, which may lead to the development of NODM. Early prevention of these factors may abate the incidence of NODM and positively impact survival rate, and thus ameliorate the worsening of cardiovascular risk factors which usually occur after LT.
authors.affiliation: Department of General Surgery and Transplantation Unit, San Giovanni di Dio e Ruggi D'Aragona University Hospital, Scuola Medica Salernitana, Via San Leonardo, Salerno, Italy. gsarno79@yahoo.it
authors.forename: Gerardo
authors.initials: G
authors.lastname: Sarno
authors.forename: Rucha J
authors.initials: RJ
authors.lastname: Mehta
authors.forename: Rodolfo
authors.initials: R
authors.lastname: Guardado-Mendoza
authors.forename: Lilia M
authors.initials: LM
authors.lastname: Jimenez-Ceja
authors.forename: Paride
authors.initials: P
authors.lastname: De Rosa
authors.forename: Giovanna
authors.initials: G
authors.lastname: Muscogiuri
mesh_terms: D006528:Carcinoma, Hepatocellular / Q000378:metabolism / Q000401:mortality / Q000601:surgery*; D002318:Cardiovascular Diseases / Q000378:metabolism / Q000401:mortality / Q000517:prevention & control*; D003924:Diabetes Mellitus, Type 2 / Q000209:etiology / Q000401:mortality / Q000517:prevention & control*; D005260:Female; D006801:Humans; D008103:Liver Cirrhosis / Q000378:metabolism / Q000401:mortality / Q000601:surgery*; D008113:Liver Neoplasms / Q000378:metabolism / Q000401:mortality / Q000601:surgery*; D016031:Liver Transplantation / Q000009:adverse effects* / Q000401:mortality; D008297:Male; D011183:Postoperative Complications; D012307:Risk Factors; D015996:Survival Rate; D016896:Treatment Outcome