title: Radiotherapy for pleomorphic adenoma.
abstract: OBJECTIVE
  The aim of this study was to update our experience in treating pleomorphic adenoma with radiotherapy (RT).
  
  
  METHODS
  This is a retrospective analysis of 25 patients treated with RT alone (2 patients) or combined with surgery (23 patients), with follow-up ranging from 1.8 to 34.9 years (median, 10.5 years).
  
  
  RESULTS
  Local control was achieved in 13 (75%) of 16 patients with subclinical disease and 5 (56%) of 9 patients with gross disease. Overall local control was achieved in 18 (72%) of 25 patients. The 5-, 10-, and 15-year overall local control rates were 76 %, 76%, and 68%, respectively. Ten patients died of the following causes: recurrent disease, 2; malignant transformation, 2; and intercurrent disease, 6. At last follow-up, 14 patients were alive without evidence of disease, and 1 patient was alive with disease. Dental carries and transient facial nerve deficits were the most common complications. No patients developed severe complications subsequent to RT.
  
  
  CONCLUSIONS
  In patients at high risk for developing recurrent pleomorphic adenoma after surgery, RT is effective in controlling subclinical disease.
authors.affiliation: Department of Radiation Oncology, University of Florida College of Medicine, Gainesville, FL 32610-0385, USA.
authors.forename: Audrey S
authors.initials: AS
authors.lastname: Wallace
authors.forename: Christopher G
authors.initials: CG
authors.lastname: Morris
authors.forename: Jessica M
authors.initials: JM
authors.lastname: Kirwan
authors.forename: John W
authors.initials: JW
authors.lastname: Werning
authors.forename: William M
authors.initials: WM
authors.lastname: Mendenhall
mesh_terms: D008949:Adenoma, Pleomorphic / Q000473:pathology / Q000532:radiotherapy*; D000328:Adult; D000368:Aged; D018572:Disease-Free Survival; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local; D011829:Radiation Dosage; D012189:Retrospective Studies; D012468:Salivary Gland Neoplasms / Q000473:pathology / Q000532:radiotherapy*; D013997:Time Factors; D016896:Treatment Outcome