title: An association and haplotype analysis of porcine maternal infanticide: a model for human puerperal psychosis?
abstract: An association analysis using the Illumina porcine SNP60 beadchip was performed to identify SNPs significantly associated with porcine maternal infanticide. We previously hypothesised that this was a good animal model for human puerperal psychosis, an extreme form of postnatal mood disorder. Animals were selected from carefully phenotyped unrelated infanticide and control groups (representing extremes of the phenotypic spectrum), from four different lines. Permutation and sliding window analyses and an analysis to see which haplotypes were in linkage disequilibrium (LD) were compared to identify concordant regions. Across all analyses, intervals on SSCs 1, 3, 4, 10, and 13 were constant, contained genes associated with psychiatric or neurological disorders and were significant in multiple lines. The strongest (near GWS) consistent candidate region across all analyses and all breeds was the one located on SSC3 with one peak at 23.4 Mb, syntenic to a candidate region for bipolar disorder and another at 31.9 Mb, syntenic to a candidate region for human puerperal psychosis (16p13). From the haplotype/LD analysis, two regions reached genome wide significance (GWS): the first on SSC4 (KHDRBS3 to FAM135B), which was significant (-logP 5.57) in one Duroc based breed and is syntenic to a region in humans associated with cognition and neurotism; the second on SSC15, which was significant (-log10P 5.68) in two breeds and contained PAX3, which is expressed in the brain.
authors.affiliation: Human Molecular Genetics Group, Department of Pathology, University of Cambridge, Cambridge, UK. crq20@cam.ac.uk
authors.forename: C R
authors.initials: CR
authors.lastname: Quilter
authors.forename: C A
authors.initials: CA
authors.lastname: Sargent
authors.forename: J
authors.initials: J
authors.lastname: Bauer
authors.forename: M R
authors.initials: MR
authors.lastname: Bagga
authors.forename: C P
authors.initials: CP
authors.lastname: Reiter
authors.forename: E L
authors.initials: EL
authors.lastname: Hutchinson
authors.forename: O I
authors.initials: OI
authors.lastname: Southwood
authors.forename: G
authors.initials: G
authors.lastname: Evans
authors.forename: A
authors.initials: A
authors.lastname: Mileham
authors.forename: D K
authors.initials: DK
authors.lastname: Griffin
authors.forename: N A
authors.initials: NA
authors.lastname: Affara
mesh_terms: D000818:Animals; D001522:Behavior, Animal; D001714:Bipolar Disorder / Q000235:genetics; D002874:Chromosome Mapping; D004268:DNA-Binding Proteins / Q000235:genetics; D019052:Depression, Postpartum / Q000235:genetics; D004195:Disease Models, Animal; D005260:Female; D020022:Genetic Predisposition to Disease; D055106:Genome-Wide Association Study; D005838:Genotype; D006239:Haplotypes; D006801:Humans; D007231:Infant, Newborn; D015810:Linkage Disequilibrium; D008425:Maternal Behavior; D020641:Polymorphism, Single Nucleotide; D011618:Psychotic Disorders / Q000235:genetics*; D011644:Puerperal Disorders / Q000235:genetics*; D040641:Quantitative Trait Loci / Q000235:genetics; D016601:RNA-Binding Proteins / Q000235:genetics; D013552:Swine
chemical_list: D004268:DNA-Binding Proteins; D016601:RNA-Binding Proteins