title: [Central nervous system complications in patients undergoing cytotoxic chemotherapy and targeted therapies].
abstract: Anti-cancer treatments (cytotoxic chemotherapies, targeted therapies and hormonotherapies) are known to induce early and delayed neurological toxicities. Acute encephalopathies and posterior reversible encephalopathies are better known and described, physiopathological hypotheses are emerging. It is difficult to discriminate what drug is causing the symptoms in patients treated with multiple cytotoxic drugs. Methotrexate and ifosfamide are responsible for acute encephalopathies. L-asparaginase and methotrexate or targeted therapies may induce cerebrovascular complications. As life expectancy increases and more complex regimen including innovative targeted therapies are developed, new toxicity profiles can be expected. To be able to provide an early diagnosis, prevention, and treatment (when existing) of these pathologies remains a tremendous challenge that would allow a good quality of life with social and professional life after their cancer is cured.
authors.affiliation: Hôpital Pitié-Salpêtrière, service de neurologie Mazarin, Paris, France.
authors.forename: Dimitri
authors.initials: D
authors.lastname: Psimaras
authors.forename: Flavie
authors.initials: F
authors.lastname: Bompaire
authors.forename: Hervé
authors.initials: H
authors.lastname: Taillia
authors.forename: Damien
authors.initials: D
authors.lastname: Ricard
authors.forename: Sophie
authors.initials: S
authors.lastname: Taillibert
mesh_terms: D020533:Angiogenesis Inhibitors / Q000009:adverse effects*; D000911:Antibodies, Monoclonal / Q000627:therapeutic use; D000970:Antineoplastic Agents / Q000009:adverse effects*; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects*; D001691:Biological Therapy / Q000009:adverse effects*; D002493:Central Nervous System Diseases / Q000139:chemically induced*; D006801:Humans; D007167:Immunotherapy / Q000009:adverse effects*
chemical_list: D020533:Angiogenesis Inhibitors; D000911:Antibodies, Monoclonal; D000970:Antineoplastic Agents