title: Natural material adsorbed onto a polymer to enhance immune function.
abstract: BACKGROUND
  In this study, we produced poly(ethylene glycol) (PEG) microspheres of different sizes and adsorbing a medicinal plant mixture, and verified their effect in vitro on the viability, superoxide production, and bactericidal activity of phagocytes in the blood.
  
  
  METHODS
  The medicinal plant mixture was adsorbed onto PEG microspheres and its effects were evaluated by flow cytometry and fluorescence microscopy.
  
  
  RESULTS
  Adsorption of the herbal mixture onto the PEG microspheres was achieved and the particles were internalized by phagocytes. PEG microspheres bearing the adsorbed herbal mixture stimulated superoxide release, and activated scavenging and microbicidal activity in phagocytes. No differences in functional activity were observed when the phagocytes were not incubated with PEG microspheres bearing the adsorbed herbal mixture.
  
  
  CONCLUSIONS
  This system may be useful for the delivery of a variety of medicinal plants and can confer additional protection against infection. The data reported here suggest that a polymer adsorbed with a natural product is a treatment alternative for enhancing immune function.
authors.affiliation: Federal University of Mato Grosso, Barra do Garças, Brazil.
authors.forename: Ana Paula Barcelos
authors.initials: AP
authors.lastname: Reinaque
authors.forename: Eduardo Luzía
authors.initials: EL
authors.lastname: França
authors.forename: Edson Fredulin
authors.initials: EF
authors.lastname: Scherer
authors.forename: Mayra Aparecida
authors.initials: MA
authors.lastname: Côrtes
authors.forename: Francisco José Dutra
authors.initials: FJ
authors.lastname: Souto
authors.forename: Adenilda Cristina
authors.initials: AC
authors.lastname: Honorio-França
mesh_terms: D000293:Adolescent; D000327:Adsorption; D000328:Adult; D004926:Escherichia coli / Q000187:drug effects; D005434:Flow Cytometry; D006801:Humans; D008297:Male; D008856:Microscopy, Fluorescence; D008863:Microspheres; D010586:Phagocytes / Q000187:drug effects* / Q000276:immunology; D010587:Phagocytosis / Q000187:drug effects; D010936:Plant Extracts / Q000008:administration & dosage* / Q000032:analysis / Q000494:pharmacology; D011092:Polyethylene Glycols / Q000008:administration & dosage*; D013481:Superoxides / Q000378:metabolism
chemical_list: D010936:Plant Extracts; D013481:Superoxides; D011092:Polyethylene Glycols