title: Breast reconstruction with autologous fat graft mixed with platelet-rich plasma.
abstract: BACKGROUND
  The purpose of this study was to review the authors' experience of fat grafting, evaluating the effects related to the use of fat grafting with platelet-rich plasma (PRP) in the improvement of fat volume in breast reconstruction and comparing the results with a control group (only centrifuged fat grafting).
  
  
  METHODS
  A total of 50 patients aged between 19 and 60 years affected by breast soft-tissue defects were analyzed at the Plastic and Reconstructive Department of the University of Tor Vergata. They were treated with fat grafting + PRP. The control group (50 patients with breast soft-tissue defects) were treated with centrifuged fat grafting injection according to Coleman's procedure.
  
  
  RESULTS
  The patients treated with PRP added to the autologous fat grafts showed a 69% maintenance of the contour restoring and of 3-dimensional volume after 1 year, whereas the patients of the control group treated with centrifuged fat grafting showed a 39% maintenance.
  
  
  CONCLUSIONS
  PRP mixed with fat grafting leads to an improvement in maintaining breast volume in patients affected by breast soft-tissue defects.
authors.affiliation: University of Study "Tor Vergata," Rome, Italy. pietrogentile2004@libero.it
authors.forename: Pietro
authors.initials: P
authors.lastname: Gentile
authors.forename: Camilla
authors.initials: C
authors.lastname: Di Pasquali
authors.forename: Ilaria
authors.initials: I
authors.lastname: Bocchini
authors.forename: Micol
authors.initials: M
authors.lastname: Floris
authors.forename: Tati
authors.initials: T
authors.lastname: Eleonora
authors.forename: Valeria
authors.initials: V
authors.lastname: Fiaschetti
authors.forename: Roberto
authors.initials: R
authors.lastname: Floris
authors.forename: Valerio
authors.initials: V
authors.lastname: Cervelli
mesh_terms: D000273:Adipose Tissue / Q000637:transplantation*; D000328:Adult; D000704:Analysis of Variance; D001940:Breast / Q000637:transplantation*; D005260:Female; D006801:Humans; D016462:Mammaplasty / Q000379:methods*; D008875:Middle Aged; D053657:Platelet-Rich Plasma; D014057:Tomography, X-Ray Computed; D014182:Transplantation, Autologous