title: Unchanged serum adipokine concentrations in the setting of short-term thyroidectomy-induced hypothyroidism.
abstract: OBJECTIVE
  To investigate short-term effects of thyroidectomy-induced hypothyroidism on leptin, adiponectin, and resistin concentrations in association with anthropometric data.
  
  
  METHODS
  Thirty premenopausal women with euthyroid nodular goiter-mean age, 44.0 ± 11.6 years; mean body mass index (BMI), 28.6 ± 5.9 kg/m2; 13 obese, 7 overweight, and 10 normal weight subjects-scheduled for total thyroidectomy were included in the study. Serum leptin, adiponectin, resistin, free triiodothyronine, free thyroxine, thyroid-stimulating hormone, glucose, insulin, and C-reactive protein concentrations, lipid profile, and anthropometric variables were determined in the euthyroid state (preoperatively) and the hypothyroid state (postoperatively, with a thyroid-stimulating hormone concentration >30 mIU/L).
  
  
  RESULTS
  Body weight, BMI, waist and hip circumferences, body fat mass, and serum lipid concentrations increased significantly after thyroidectomy. No significant difference was found between preoperative and postoperative serum leptin, adiponectin, and resistin concentrations. Fat tissue mass-corrected leptin, adiponectin, and resistin concentrations did not differ significantly between euthyroid and hypothyroid periods. Thyroid hormone concentrations showed no significant correlations with adipokine levels.
  
  
  CONCLUSIONS
  Serum adipokine concentrations seem not to change significantly during short-term thyroidectomy-induced hypothyroidism despite significant increases in body weight, BMI, fat mass, and lipid concentrations.
authors.affiliation: Department of Internal Medicine, Istanbul Training and Research Hospital, Istanbul, Turkey.
authors.forename: Ozlem
authors.initials: O
authors.lastname: Kaplan
authors.forename: Ayse Kubat
authors.initials: AK
authors.lastname: Uzum
authors.forename: Hale
authors.initials: H
authors.lastname: Aral
authors.forename: Gungor
authors.initials: G
authors.lastname: Uzum
authors.forename: Vahit
authors.initials: V
authors.lastname: Tunali
authors.forename: Ozlem
authors.initials: O
authors.lastname: Demir
authors.forename: Kezban Nur
authors.initials: KN
authors.lastname: Planci
authors.forename: Ozgu
authors.initials: O
authors.lastname: Kesmezacar
authors.forename: Nese Colak
authors.initials: NC
authors.lastname: Ozbey
mesh_terms: D054392:Adipokines / Q000097:blood*; D000328:Adult; D015992:Body Mass Index; D001835:Body Weight; D005260:Female; D005500:Follow-Up Studies; D006044:Goiter, Nodular / Q000601:surgery; D006801:Humans; D007037:Hypothyroidism / Q000097:blood* / Q000209:etiology*; D020738:Leptin / Q000097:blood; D008055:Lipids / Q000097:blood; D008875:Middle Aged; D052243:Resistin / Q000097:blood; D013965:Thyroidectomy / Q000009:adverse effects*
chemical_list: D054392:Adipokines; D020738:Leptin; D008055:Lipids; D052243:Resistin