title: Features of Urrets-Zavalia syndrome after descemet stripping automated endothelial keratoplasty.
abstract: OBJECTIVE
  To report a case series of pupil abnormalities consistent with features of Urrets-Zavalia syndrome (UZS) after Descemet stripping automated endothelial keratoplasty (DSAEK) for corneal edema secondary to corneal endothelial cell dysfunction.
  
  
  METHODS
  Retrospective chart analysis of subjects who developed UZS after DSAEK at the University of Texas Southwestern Medical Center.
  
  
  RESULTS
  We present a series of 7 eyes with features consistent with UZS, after undergoing DSAEK. Elevated intraocular pressures (IOP) were noted in the early postoperative period in all cases. Five of 7 had graft dislocation in the postoperative period and required rebubbling or repeat DSAEK to obtain a well-apposed graft. Patients were followed for 3 to 14 months and showed improvement in visual acuity and IOP, but fixed dilated pupils persisted.
  
  
  CONCLUSIONS
  A fixed irregular or dilated pupil is a rare complication that can be associated with DSAEK surgery. Patients with an elevated IOP and complicated postoperative course seem to be at greater risk for developing iris ischemia and pupil abnormalities consistent with the diagnosis of UZS.
authors.affiliation: Department of Ophthalmology, University of Texas Southwestern Medical Center, Dallas, TX 75390-9057, USA.
authors.forename: Didar S
authors.initials: DS
authors.lastname: Anwar
authors.forename: Claire Y
authors.initials: CY
authors.lastname: Chu
authors.forename: Pawan
authors.initials: P
authors.lastname: Prasher
authors.forename: Robert W
authors.initials: RW
authors.lastname: Bowman
authors.forename: V Vinod
authors.initials: VV
authors.lastname: Mootha
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000959:Antihypertensive Agents / Q000008:administration & dosage; D001284:Atrophy; D057111:Descemet Stripping Endothelial Keratoplasty / Q000009:adverse effects*; D005260:Female; D005642:Fuchs' Endothelial Dystrophy / Q000601:surgery; D006801:Humans; D007429:Intraocular Pressure / Q000187:drug effects; D007498:Iris / Q000473:pathology*; D019654:Lens Implantation, Intraocular; D008297:Male; D008875:Middle Aged; D015878:Mydriasis / Q000175:diagnosis* / Q000209:etiology; D009798:Ocular Hypertension / Q000188:drug therapy / Q000209:etiology; D018918:Phacoemulsification; D011183:Postoperative Complications; D011681:Pupil Disorders / Q000175:diagnosis* / Q000209:etiology; D012189:Retrospective Studies; D012307:Risk Factors; D014792:Visual Acuity / Q000502:physiology
chemical_list: D000959:Antihypertensive Agents