title: Fetuin-A triggers the secretion of a novel set of exosomes in detached tumor cells that mediate their adhesion and spreading.
abstract: Our goal in this study was to define the mechanisms by which fetuin-A mediates the adhesion of tumor cells. The data show that in the absence of fetuin-A, detached tumor cells secrete exosomes that contain most of the known exosomal associated proteins but lack the capacity to mediate cellular adhesion. In the presence of fetuin-A, the cells secrete exosomes, which contain, in addition to the other exosomal proteins, fetuin-A, plasminogen and histones. These exosomes mediate adhesion and cell spreading. Plasminogen is a participant in this novel adhesion mechanism. The data suggest that these exosomes play a role in tumor progression.
authors.affiliation: Department of Biochemistry, Meharry Medical College, Nashville, TN 37208, United States.
authors.forename: Kurt
authors.initials: K
authors.lastname: Watson
authors.forename: Rainelli
authors.initials: R
authors.lastname: Koumangoye
authors.forename: Pamela
authors.initials: P
authors.lastname: Thompson
authors.forename: Amos M
authors.initials: AM
authors.lastname: Sakwe
authors.forename: Tina
authors.initials: T
authors.lastname: Patel
authors.forename: Siddharth
authors.initials: S
authors.lastname: Pratap
authors.forename: Josiah
authors.initials: J
authors.lastname: Ochieng
mesh_terms: D001943:Breast Neoplasms / Q000473:pathology / Q000503:physiopathology; D002448:Cell Adhesion / Q000502:physiology; D045744:Cell Line, Tumor; D002465:Cell Movement / Q000502:physiology; D015179:Colorectal Neoplasms / Q000473:pathology / Q000503:physiopathology; D055354:Exosomes / Q000502:physiology*; D005260:Female; D006801:Humans; D008954:Models, Biological; D009361:Neoplasm Invasiveness / Q000473:pathology / Q000503:physiopathology; D009363:Neoplasm Proteins / Q000502:physiology; D009369:Neoplasms / Q000473:pathology* / Q000503:physiopathology*; D010958:Plasminogen / Q000502:physiology; D060749:alpha-2-HS-Glycoprotein / Q000502:physiology*
chemical_list: C556354:AHSG protein, human; D009363:Neoplasm Proteins; D060749:alpha-2-HS-Glycoprotein; D010958:Plasminogen