title: Tetrapeptide H-Ala-Glu-Asp-Arg-OH stimulates expression of cytoskeletal and nuclear matrix proteins.
abstract: Tetrapeptide H-Ala-Glu-Asp-Arg-OH enhances the expression of cytoskeletal (actin, tubulin, vimentin) and nuclear matrix proteins (lamin A, lamin C) in cultured mouse embryonic fibroblasts by 2-5 and 2-3 times, respectively. Thus, the previously reported cardioprotective activity of this tetrapeptide is determined by its capacity to activate synthesis of cytoskeletal and nuclear matrix proteins, which stimulates cell proliferation and reduces apoptosis.
authors.affiliation: I. P. Pavlov Institute of Physiology, Russian Academy of Sciences, St. Petersburg, Russia.
authors.forename: V Kh
authors.initials: VKh
authors.lastname: Khavinson
authors.forename: N S
authors.initials: NS
authors.lastname: Lin'kova
authors.forename: V O
authors.initials: VO
authors.lastname: Polyakova
authors.forename: I M
authors.initials: IM
authors.lastname: Kvetnoy
authors.forename: V V
authors.initials: VV
authors.lastname: Benberin
authors.forename: M M
authors.initials: MM
authors.lastname: D'yakonov
authors.forename: Yu S
authors.initials: YS
authors.lastname: Titkov
mesh_terms: D000818:Animals; D017209:Apoptosis / Q000187:drug effects; D049109:Cell Proliferation / Q000187:drug effects; D002478:Cells, Cultured; D003598:Cytoskeletal Proteins / Q000378:metabolism*; D005347:Fibroblasts; D005786:Gene Expression Regulation / Q000187:drug effects*; D007091:Image Processing, Computer-Assisted; D034904:Lamin Type A / Q000235:genetics; D051379:Mice; D018345:Mice, Knockout; D008856:Microscopy, Fluorescence; D034521:Nuclear Matrix-Associated Proteins / Q000378:metabolism*; D009842:Oligopeptides / Q000494:pharmacology*
chemical_list: D003598:Cytoskeletal Proteins; D034904:Lamin Type A; C576142:Lmna protein, mouse; D034521:Nuclear Matrix-Associated Proteins; D009842:Oligopeptides