title: Bone mineral density in patients with stroke: relationship with motor impairment and functional mobility.
abstract: OBJECTIVE
  Patients with stroke have a 2- to 4-fold increased risk of hip fracture compared to the general population, because of decreased bone mineral density (BMD) on the paretic side and the high incidence of accidental falls. However, the relationship between BMD and stroke-related motor impairment and functional mobility is not known. The purpose of this study was to investigate these relationships.
  
  
  METHODS
  A convenience sample of 87 patients with stroke was recruited from an outpatient rehabilitation clinic. Demographics and clinical history were collected, and patients answered questionnaires regarding functional status. Motor impairment was assessed using motor items of the National Institutes of Health Stroke Scale (NIHSS), and BMD was measured using dual energy X-ray absorptiometry.
  
  
  RESULTS
  Mean BMD measured at the total hip was lower on the paretic side relative to the contralateral side (0.883 ± 0.148 g/cm2 vs 0.923 ± 0.136 g/cm2;P < .001). Compared to patients without limitations in walking, those reporting limitations had lower BMD at the paretic total hip (0.808 ± 0.141 g/cm2 vs 0.917 ± 0.139 g/cm2;P = .001) and lower BMDZ scores (-0.282 ± 0.888 vs -0.028 ± 0.813;P = .035). A significant correlation was found between mean BMD and the BMDZ score at the total hip on the paretic side and motor impairment in that lower extremity (r = -0.326,P = .003;r = -0.312,P = .004, respectively).
  
  
  CONCLUSIONS
  In patients with stroke, BMD at the paretic hip correlated with motor impairment. Furthermore, ability to ambulate was shown to be a simple yet useful test to determine which individuals had increased bone loss at the paretic versus nonparetichip.
authors.affiliation: Department of Physical Medicine and Rehabilitation, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.
authors.forename: Thomas J
authors.initials: TJ
authors.lastname: Schnitzer
authors.forename: Richard L
authors.initials: RL
authors.lastname: Harvey
authors.forename: S Hillary
authors.initials: SH
authors.lastname: Nack
authors.forename: P
authors.initials: P
authors.lastname: Supanwanid
authors.forename: L
authors.initials: L
authors.lastname: Maskala-Streff
authors.forename: E
authors.initials: E
authors.lastname: Roth
mesh_terms: D015502:Absorptiometry, Photon; D000368:Aged; D015519:Bone Density / Q000502:physiology*; D005260:Female; D006620:Hip Fractures / Q000453:epidemiology; D006621:Hip Joint / Q000000981:diagnostic imaging / Q000503:physiopathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D009043:Motor Activity / Q000502:physiology; D019957:Motor Skills Disorders / Q000453:epidemiology / Q000503:physiopathology* / Q000534:rehabilitation*; D010291:Paresis / Q000453:epidemiology / Q000503:physiopathology / Q000534:rehabilitation; D020127:Recovery of Function / Q000502:physiology; D012307:Risk Factors; D020521:Stroke / Q000453:epidemiology / Q000503:physiopathology*; D000071939:Stroke Rehabilitation