title: Study of tumor growth under hyperthermia condition.
abstract: The new concept of keeping primary tumor under control in situ to suppress distant foci sheds light on the treatment of metastatic tumor. Hyperthermia is considered as one of the means for controlling tumor growth. To simulate the tumor growth, a continuum mathematical model has been introduced. The newest understanding of the Warburg effect on the cellular metabolism and diffusion of the nutrients in the tissue has been taken into consideration. The numerical results are compared with the in vivo experimental data by fitting the tumor cell doubling time/tumor cell growth rate under different thermal conditions. Both the tumor growth curve and corresponding average glucose concentration have been predicted. The numerical results have quantitatively illustrated the controlling effect on tumor growth under hyperthermia condition in the initial stage.
authors.affiliation: School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai 200240, China.
authors.forename: Qing
authors.initials: Q
authors.lastname: Zhu
authors.forename: Aili
authors.initials: A
authors.lastname: Zhang
authors.forename: Ping
authors.initials: P
authors.lastname: Liu
authors.forename: Lisa X
authors.initials: LX
authors.lastname: Xu
mesh_terms: D000818:Animals; D049109:Cell Proliferation; D019295:Computational Biology / Q000379:methods; D003198:Computer Simulation; D005334:Fever / Q000503:physiopathology*; D005947:Glucose / Q000378:metabolism; D006801:Humans; D006979:Hyperthermia, Induced / Q000379:methods; D051379:Mice; D008807:Mice, Inbred BALB C; D008954:Models, Biological; D015233:Models, Statistical; D008962:Models, Theoretical; D009362:Neoplasm Metastasis; D009369:Neoplasms / Q000473:pathology*; D013997:Time Factors
chemical_list: D005947:Glucose