title: Biocompatible hydrogels by oxime Click chemistry.
abstract: Oxime Click chemistry was used to form hydrogels that support cell adhesion. Eight-armed aminooxy poly(ethylene glycol) (PEG) was mixed with glutaraldehyde to form oxime-linked hydrogels. The mechanical properties, gelation kinetics, and water swelling ratios were studied and found to be tunable. It was also shown that gels containing the integrin ligand arginine-glycine-aspartic acid (RGD) supported mesenchymal stem cell (MSC) incorporation. High cell viability and proliferation of the encapsulated cells demonstrated biocompatibility of the material.
authors.affiliation: Department of Chemistry and Biochemistry, University of California, Los Angeles, CA 90095, USA.
authors.forename: Gregory N
authors.initials: GN
authors.lastname: Grover
authors.forename: Jonathan
authors.initials: J
authors.lastname: Lam
authors.forename: Thi H
authors.initials: TH
authors.lastname: Nguyen
authors.forename: Tatiana
authors.initials: T
authors.lastname: Segura
authors.forename: Heather D
authors.initials: HD
authors.lastname: Maynard
mesh_terms: D001672:Biocompatible Materials / Q000138:chemical synthesis* / Q000737:chemistry; D049109:Cell Proliferation; D002470:Cell Survival; D057930:Click Chemistry; D005976:Glutaral / Q000737:chemistry; D020100:Hydrogels / Q000138:chemical synthesis* / Q000737:chemistry; D007700:Kinetics; D059630:Mesenchymal Stem Cells / Q000737:chemistry; D009842:Oligopeptides / Q000737:chemistry; D010091:Oximes / Q000138:chemical synthesis / Q000737:chemistry*; D011092:Polyethylene Glycols / Q000737:chemistry
chemical_list: D001672:Biocompatible Materials; D020100:Hydrogels; D009842:Oligopeptides; D010091:Oximes; D011092:Polyethylene Glycols; C047981:arginyl-glycyl-aspartic acid; D005976:Glutaral