title: MiR-136 promotes apoptosis of glioma cells by targeting AEG-1 and Bcl-2.
abstract: MicroRNAs have the capacity to coordinately repress multiple target genes and interfere with biological functions of the cell, such as proliferation and apoptosis. Here we report that miR-136 is downregulated in human glioma, and that the miRNA promotes apoptosis of glioma cells induced by chemotherapy. Two anti-apoptotic genes, AEG-1 and Bcl-2, are identified as targets of miR-136, and restoration of AEG-1 or Bcl-2 expression suppresses miR-136-enhanced apoptosis. Therefore, miR-136 might play a tumor-suppressive role in human glioma and thereby might represent a potential therapeutic strategy.
authors.affiliation: Key Laboratory of Tropical Disease Control, Sun Yat-Sen University, Ministry of Education, Guangzhou, Guangdong, China.
authors.forename: Yi
authors.initials: Y
authors.lastname: Yang
authors.forename: Jueheng
authors.initials: J
authors.lastname: Wu
authors.forename: Hongyu
authors.initials: H
authors.lastname: Guan
authors.forename: Junchao
authors.initials: J
authors.lastname: Cai
authors.forename: Lishan
authors.initials: L
authors.lastname: Fang
authors.forename: Jun
authors.initials: J
authors.lastname: Li
authors.forename: Mengfeng
authors.initials: M
authors.lastname: Li
mesh_terms: D017209:Apoptosis / Q000187:drug effects / Q000235:genetics*; D001483:Base Sequence; D015815:Cell Adhesion Molecules / Q000235:genetics*; D002945:Cisplatin / Q000494:pharmacology; D015536:Down-Regulation / Q000187:drug effects / Q000235:genetics; D005910:Glioma / Q000235:genetics* / Q000473:pathology*; D006801:Humans; D008565:Membrane Proteins; D035683:MicroRNAs / Q000235:genetics* / Q000378:metabolism*; D019253:Proto-Oncogene Proteins c-bcl-2 / Q000235:genetics*; D016601:RNA-Binding Proteins
chemical_list: D015815:Cell Adhesion Molecules; C577037:MIRN136 microRNA, human; C483039:MTDH protein, human; D008565:Membrane Proteins; D035683:MicroRNAs; D019253:Proto-Oncogene Proteins c-bcl-2; D016601:RNA-Binding Proteins; D002945:Cisplatin