title: Significance of aldehyde dehydrogenase 1 expression in stromal cells of diffuse large B-cell lymphoma.
abstract: Aldehyde dehydrogenase (ALDH) 1 is expressed in various stem/progenitor cells, including cancer-initiating cells (CICs). In the present study, ALDH1 expression was immunohistochemically examined in diffuse large B-cell lymphoma (DLBCL). Unexpectedly, ALDH1 expression was occasionally detected in stromal cells, but not in lymphoma cells. Positively stained cells were CD68(+) cells with voluminous cytoplasm and fascin(+) cells with reticular morphology, designated as macrophages and dendritic cells (DCs), respectively. The presence of ALDH1(+) macrophages was not correlated with stage, response to therapies and prognosis. However, cases with ALDH1(+) DCs were mostly nodal, which showed a poorer response to therapies and a worse overall survival rate than cases without ALDH1(+) DCs. The presence of ALDH1(+) DCs appears to be involved in the malignant potential of DLBCL in lymph node.
authors.affiliation: Department of Pathology, Osaka University Graduate School of Medicine, Suita 565-0871,  Japan.
authors.forename: Shigeki
authors.initials: S
authors.lastname: Fujita
authors.forename: Eiichi
authors.initials: E
authors.lastname: Morii
authors.forename: Nur
authors.initials: N
authors.lastname: Rahadiani
authors.forename: Naoki
authors.initials: N
authors.lastname: Wada
authors.forename: Yumiko
authors.initials: Y
authors.lastname: Hori
authors.forename: Jun-Ichiro
authors.initials: JI
authors.lastname: Ikeda
authors.forename: Katsuyuki
authors.initials: K
authors.lastname: Aozasa