title: EGFR mutations and human papillomavirus in lung cancer.
abstract: Our previous study reported a frequent detection of human papillomavirus (HPV) genome in primary lung adenocarcinomas of the recurrent patients who were responsive to epidermal growth factor receptor (EGFR)-tyrosine kinase inhibitor, suggesting that HPV presence in lung cancer may be related to a genetic background related to EGFR mutations. The present study examined the association between the HPV presence and mutations in exons 19 and 21 of EGFR gene in Japanese lung cancer patients. Thirteen (31%) out of 42 cases had EGFR mutations. Although these mutations were tended to be observed in females, non-smokers, or adenocarcinomas, there was no statistically significant associations. HPV DNA was found in 7/42 (17%) lung tumors. The frequency of HPV presence did not differ in histological types. The presence of HPV DNA was significantly related to EGFR mutations (P=0.021), especially in adenocarcinomas of the lung (P=0.014). HPV-positive lung tumors accounted for 38% and 7% of those with and without EGFR mutations, respectively. Our results suggest that EGFR mutations are associated with HPV presence in Japanese patients with lung cancer.
authors.affiliation: Department of Epidemiology and Preventive Medicine, Graduate School of Medical and Dental Sciences, Kagoshima University, 8-35-1 Sakuragaoka, Kagoshima 890-8544, Japan.
authors.forename: Takuya
authors.initials: T
authors.lastname: Kato
authors.forename: Chihaya
authors.initials: C
authors.lastname: Koriyama
authors.forename: Noureen
authors.initials: N
authors.lastname: Khan
authors.forename: Takuya
authors.initials: T
authors.lastname: Samukawa
authors.forename: Masakazu
authors.initials: M
authors.lastname: Yanagi
authors.forename: Tsutomu
authors.initials: T
authors.lastname: Hamada
authors.forename: Naoya
authors.initials: N
authors.lastname: Yokomakura
authors.forename: Takeshi
authors.initials: T
authors.lastname: Otsuka
authors.forename: Hiromasa
authors.initials: H
authors.lastname: Inoue
authors.forename: Masami
authors.initials: M
authors.lastname: Sato
authors.forename: Shoji
authors.initials: S
authors.lastname: Natsugoe
authors.forename: Suminori
authors.initials: S
authors.lastname: Akiba
mesh_terms: D000230:Adenocarcinoma / Q000235:genetics* / Q000821:virology; D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000235:genetics* / Q000821:virology; D066246:ErbB Receptors / Q000235:genetics*; D005260:Female; D052162:Human papillomavirus 16 / Q000235:genetics / Q000502:physiology*; D006801:Humans; D008175:Lung Neoplasms / Q000235:genetics* / Q000821:virology; D008297:Male; D009154:Mutation; D030361:Papillomavirus Infections / Q000235:genetics* / Q000821:virology; D019562:Viral Load
chemical_list: D066246:ErbB Receptors