title: Effect of NF-κB inhibitor aurothiomalate on local inflammation in experimental Th1- and Th2-type immune response.
abstract: We compared the effect of NF-κB inhibitor aurothiomalate and voltaren on local inflammation in different types of immune response. Both substances reduced edema caused by sheep erythrocytes (Th1-type immune response) and local immediate-type hypersensitivity response induced with ovalbumin (Th2-dependent response). The anti-inflammatory effects of aurothiomalate were similar to those of voltaren during Th1-type immune response.
authors.affiliation: Institute of Pharmacology, Siberian Division of the Russian Academy of Medical Sciences, Tomsk, Russia. vittelli@mail.ru
authors.forename: A A
authors.initials: AA
authors.lastname: Ligacheva
authors.forename: A N
authors.initials: AN
authors.lastname: Ivanova
authors.forename: Yu P
authors.initials: YP
authors.lastname: Belsky
authors.forename: N V
authors.initials: NV
authors.lastname: Belska
authors.forename: E S
authors.initials: ES
authors.lastname: Trofimova
authors.forename: M G
authors.initials: MG
authors.lastname: Danilets
authors.forename: A M
authors.initials: AM
authors.lastname: Dygai
mesh_terms: D000704:Analysis of Variance; D000818:Animals; D016207:Cytokines / Q000276:immunology; D004008:Diclofenac / Q000494:pharmacology / Q000627:therapeutic use; D004912:Erythrocytes; D005260:Female; D006052:Gold Sodium Thiomalate / Q000494:pharmacology* / Q000627:therapeutic use; D006968:Hypersensitivity, Delayed / Q000139:chemically induced / Q000188:drug therapy*; D006969:Hypersensitivity, Immediate / Q000139:chemically induced / Q000188:drug therapy*; D007111:Immunity, Cellular / Q000276:immunology*; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D016328:NF-kappa B / Q000037:antagonists & inhibitors*; D010047:Ovalbumin / Q000633:toxicity; D018417:Th1 Cells / Q000276:immunology*; D018418:Th2 Cells / Q000276:immunology*
chemical_list: D016207:Cytokines; D016328:NF-kappa B; D006052:Gold Sodium Thiomalate; D004008:Diclofenac; D010047:Ovalbumin