title: Gastric dysmotility and low serum vitamin D levels in patients with gastroparesis.
abstract: Nutritional abnormalities are common in patients with gastroparesis (Gp), a disorder that may affect gastric motility and may delay emptying. The aim of this work was to identify relationships between serum nutrition markers including 25-OH vitamin D and gastric motility measures in Gp patients. We enrolled 59 consecutive gastric motility clinic patients (48 females, 11 males; mean age 44 years; 42 idiopathic; 17 diabetes mellitus) with Gp symptoms. The 25-OH vitamin D levels, for most patients slightly above the lower limit of normal (96.98 nmol/l ± 60.99), were lowest in diabetic range (DM) (75.68 nmol/l ± 34.22) vs. idiopathic (ID) (105.03 nmol/l ± 67.08) gastroparesis patients. First hour GET: one unit increase in 25-OH vitamin D level was associated 0.11% improvement (95% CI -0.22, 0.01 p=0.056) in gastric motility in all patients; this association, although marked in ID Gp patients, (-0.13, CI -0.25, -0.01 p=0.034), was not seen in DM Gp, (0.2, CI -0.45, 0.87, p=0.525). Fourth hour GET: Every unit increase of 25-OH vitamin D was associated with significant improvement in all patients, ( 0.11% CI -0.23, 0.01, p=0.053), and some weak improvement in ID group, (0.11% -0.24, 0.01, p=0.076) and absent in patients with DM (0.03, CI -0.66, 0.72, p=0.932). It is concluded that 25-OH vitamin D levels may influence gastric emptying. Underlying mechanisms for this observation might include the impact of 25-OH vitamin D on the health of the enteric nervous system. 25-OH vitamin D contributions to enteric nerve functions should be explored, particularly where autonomic nervous system comorbidities exist.
authors.affiliation: Division of Digestive Diseases, Department of Medicine, University of Mississippi Medical Center, Jackson, Mississippi 39216, USA. akedar@umc.edu
authors.forename: A
authors.initials: A
authors.lastname: Kedar
authors.forename: Y
authors.initials: Y
authors.lastname: Nikitina
authors.forename: O R
authors.initials: OR
authors.lastname: Henry
authors.forename: K B
authors.initials: KB
authors.lastname: Abell
authors.forename: V
authors.initials: V
authors.lastname: Vedanarayanan
authors.forename: M E
authors.initials: ME
authors.lastname: Griswold
authors.forename: C
authors.initials: C
authors.lastname: Subramony
authors.forename: T L
authors.initials: TL
authors.lastname: Abell
mesh_terms: D000328:Adult; D001798:Blood Proteins / Q000378:metabolism; D005260:Female; D005746:Gastric Emptying; D005769:Gastrointestinal Motility / Q000502:physiology*; D018589:Gastroparesis / Q000097:blood* / Q000503:physiopathology*; D006801:Humans; D008297:Male; D018977:Micronutrients / Q000097:blood; D014807:Vitamin D / Q000097:blood*
chemical_list: D001798:Blood Proteins; D018977:Micronutrients; D014807:Vitamin D