title: Influence of donor microbiota on the severity of experimental graft-versus-host-disease.
abstract: The link between microbial flora and the shaping of immune responses is being increasingly appreciated, and recent data have uncovered a role for recipient microbiota in the severity of graft-versus-host disease (GVHD). The impact of donor microbiota on T cell-mediated alloresponses and GVHD is not known, however. Using multiple clinically relevant murine models, we analyzed the effect of donor microbiota on the severity of GVHD induced by T cells from specific pathogen-free and germ-free donors, and found that donor microbiota does not alter the expansion or differentiation of alloreactive T cells or the severity of GVHD.
authors.affiliation: Department of Internal Medicine, University of Michigan Comprehensive Cancer Center, Ann Arbor, Michigan, USA.
authors.forename: Isao
authors.initials: I
authors.lastname: Tawara
authors.forename: Chen
authors.initials: C
authors.lastname: Liu
authors.forename: Hiroya
authors.initials: H
authors.lastname: Tamaki
authors.forename: Tomomi
authors.initials: T
authors.lastname: Toubai
authors.forename: Yaping
authors.initials: Y
authors.lastname: Sun
authors.forename: Rebecca
authors.initials: R
authors.lastname: Evers
authors.forename: Evelyn
authors.initials: E
authors.lastname: Nieves
authors.forename: Nathan
authors.initials: N
authors.lastname: Mathewson
authors.forename: Gabriel
authors.initials: G
authors.lastname: Nunez
authors.forename: Pavan
authors.initials: P
authors.lastname: Reddy
mesh_terms: D000818:Animals; D001419:Bacteria / Q000276:immunology*; D002454:Cell Differentiation / Q000276:immunology*; D049109:Cell Proliferation; D004195:Disease Models, Animal; D006086:Graft vs Host Disease / Q000276:immunology* / Q000382:microbiology* / Q000473:pathology; D051379:Mice; D012720:Severity of Illness Index; D013601:T-Lymphocytes / Q000276:immunology* / Q000473:pathology