title: One-pot access to a library of structurally diverse nicotinamide derivatives via a three-component formal aza [3 + 3] cycloaddition.
abstract: The three-component formal [3 + 3] aza-annulation between chalcones, β-ketoamides, and ammonium acetate in the presence of CAN as a Lewis acid affords good to excellent yields of highly substituted nicotinamides or their fused derivatives. This transformation leads to the formation of one C-C and two C-N bonds in a single synthetic operation and involves up to five individual steps.
authors.affiliation: Departamento de Química Orgánica y Farmacéutica, Universidad Complutense , 28040 Madrid, Spain.
authors.forename: Giammarco
authors.initials: G
authors.lastname: Tenti
authors.forename: Ma Teresa
authors.initials: MT
authors.lastname: Ramos
authors.forename: J Carlos
authors.initials: JC
authors.lastname: Menéndez
mesh_terms: D000085:Acetates / Q000737:chemistry*; D000577:Amides / Q000737:chemistry*; D047188:Chalcones / Q000737:chemistry*; D020650:Combinatorial Chemistry Techniques; D003500:Cyclization; D015394:Molecular Structure; D009536:Niacinamide / Q000138:chemical synthesis / Q000737:chemistry*
chemical_list: D000085:Acetates; D000577:Amides; D047188:Chalcones; C520957:beta-ketoamide; D009536:Niacinamide; C018824:ammonium acetate