title: Evidence-based practice: sublingual immunotherapy for allergic rhinitis.
abstract: In this article, the authors review the current evidence regarding the public health and economic impact of allergic rhinitis. Diagnostic methods for allergic disease are discussed as well as certain nuances of allergy skin testing protocols. In addition, the evidence supporting sublingual immunotherapy (SLIT) for allergic rhinitis is reviewed, with subsequent attention to certain subgroups, such as adults and children, seasonal versus perennial allergens, and SLIT efficacy for individual antigens. The authors consider the evidence supporting appropriate SLIT dosing as well as the existing data on SLIT safety.
authors.affiliation: Otolaryngology-Head and Neck Surgery, Emory University, 550 Peachtree Street, MOT 9th Floor, Atlanta, GA 30308, USA.
authors.forename: Sarah K
authors.initials: SK
authors.lastname: Wise
authors.forename: Rodney J
authors.initials: RJ
authors.lastname: Schlosser
mesh_terms: D000286:Administration, Sublingual; D000328:Adult; D000485:Allergens / Q000145:classification / Q000627:therapeutic use; D002648:Child; D003888:Desensitization, Immunologic / Q000379:methods*; D004305:Dose-Response Relationship, Drug; D004391:Dust; D055317:Evidence-Based Practice; D006801:Humans; D007073:Immunoglobulin E / Q000097:blood; D011058:Pollen; D016032:Randomized Controlled Trials as Topic; D012221:Rhinitis, Allergic, Perennial / Q000175:diagnosis / Q000276:immunology / Q000628:therapy*; D006255:Rhinitis, Allergic, Seasonal / Q000175:diagnosis / Q000276:immunology / Q000628:therapy*; D012307:Risk Factors; D012882:Skin Tests; D016896:Treatment Outcome
chemical_list: D000485:Allergens; D004391:Dust; D007073:Immunoglobulin E