title: Detection of coronary thrombosis after multi-phase postmortem CT-angiography.
abstract: The aim of this study was to compare postmortem angiography-based, autopsy-based and histology-based diagnoses of acute coronary thrombosis in a series of medicolegal cases that underwent postmortem angiographies according to multiphase CT-angiography protocol. Our study included 150 medicolegal cases. All cases underwent native CT-scan, postmortem angiography, complete conventional autopsy and histological examination of the main organs and coronary arteries. In 10 out of the 150 investigated cases, postmortem angiographies revealed coronary arterial luminal filling defects and the absence of collateral vessels, suggesting acute coronary thromboses. Radiological findings were confirmed by autopsy and histological examinations in all cases. In 40 out of 150 cases, angiograms revealed complete or incomplete coronary arterial luminal filling defects and the presence of collateral vessels. Histological examinations did not reveal free-floating or non-adherent thrombi in the coronary arteries in any of these cases. Though postmortem angiography examination has not been well-established for the diagnosis of acute coronary thrombosis, luminal filling defects in coronary arteries suggesting acute thromboses can be observed through angiography and subsequently confirmed by autopsy and histological examinations.
authors.affiliation: University Center of Legal Medicine, Lausanne-Geneva, University Hospital of Lausanne, Rue du Bugnon 21, Lausanne, Switzerland. cristian.palmiere@chuv.ch
authors.forename: Cristian
authors.initials: C
authors.lastname: Palmiere
authors.forename: Johannes Alexander
authors.initials: JA
authors.lastname: Lobrinus
authors.forename: Patrice
authors.initials: P
authors.lastname: Mangin
authors.forename: Silke
authors.initials: S
authors.lastname: Grabherr
mesh_terms: D000328:Adult; D000368:Aged; D001344:Autopsy / Q000379:methods*; D017023:Coronary Angiography / Q000379:methods*; D003328:Coronary Thrombosis / Q000473:pathology*; D003331:Coronary Vessels / Q000473:pathology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D014057:Tomography, X-Ray Computed / Q000379:methods