title: Novel biochip platform for nucleic acid analysis.
abstract: This manuscript describes the use of a novel biochip platform for the rapid analysis/identification of nucleic acids, including DNA and microRNAs, with very high specificity. This approach combines a unique dynamic chemistry approach for nucleic acid testing and analysis developed by DestiNA Genomics with the STMicroelectronics In-Check platform, which comprises two microfluidic optimized and independent PCR reaction chambers, and a sequential microarray area for nucleic acid capture and identification by fluorescence. With its compact bench-top "footprint" requiring only a single technician to operate, the biochip system promises to transform and expand routine clinical diagnostic testing and screening for genetic diseases, cancers, drug toxicology and heart disease, as well as employment in the emerging companion diagnostics market.
authors.affiliation: DestiNA Genomics Ltd., West Mains Road, Edinburgh, UK. salvatore.pernagallo@destinagenomics.com
authors.forename: Salvatore
authors.initials: S
authors.lastname: Pernagallo
authors.forename: Giorgio
authors.initials: G
authors.lastname: Ventimiglia
authors.forename: Claudia
authors.initials: C
authors.lastname: Cavalluzzo
authors.forename: Enrico
authors.initials: E
authors.lastname: Alessi
authors.forename: Hugh
authors.initials: H
authors.lastname: Ilyine
authors.forename: Mark
authors.initials: M
authors.lastname: Bradley
authors.forename: Juan J
authors.initials: JJ
authors.lastname: Diaz-Mochon
mesh_terms: D001483:Base Sequence; D023281:Genomics; D006801:Humans; D008574:Mengovirus / Q000235:genetics; D035683:MicroRNAs / Q000032:analysis / Q000235:genetics; D046210:Microfluidic Analytical Techniques / Q000379:methods*; D008969:Molecular Sequence Data; D015341:Nucleic Acid Probes / Q000378:metabolism; D009696:Nucleic Acids / Q000032:analysis*; D009841:Oligonucleotides / Q000235:genetics; D012367:RNA, Viral / Q000032:analysis / Q000235:genetics; D015203:Reproducibility of Results
chemical_list: C531907:MIRN122 microRNA, human; D035683:MicroRNAs; D015341:Nucleic Acid Probes; D009696:Nucleic Acids; D009841:Oligonucleotides; D012367:RNA, Viral