title: Effect of tripeptide Lys-Glu-Asp on physiological activity of neuroimmunoendocrine system cells.
abstract: Tripeptide Lys-Glu-Asp stimulates proliferation and inhibits apoptosis in organotypic cultures of neuroimmunoendocrine system cells. Lys-Glu-Asp accelerates cell renewal processes (decrease of apoptosis marker p53 and increase of proliferation marker Ki-67) in the pineal gland; this effect is more pronounced in cultures derived from old animals than in young cultures. The tripeptide induces the expression of low-differentiated lymphocyte marker CD5 and macrophage marker CD68, but in "old" cultures this effect is less pronounced than in "young" ones. Thus, in tissue culture Lys-Glu-Asp primarily affects the nervous and endocrine tissues during aging and produces a less pronounced effect on the nervous tissue. Physiological activity of the tripeptide consists in modulation of associative learning of honey bee in the model of short-term and the long-term memory.
authors.affiliation: N. I. Pavlov Institute of Physiology, Russian Academy of Sciences, St. Petersburg, Russia.
authors.forename: N I
authors.initials: NI
authors.lastname: Chalisova
authors.forename: N G
authors.initials: NG
authors.lastname: Lopatina
authors.forename: N G
authors.initials: NG
authors.lastname: Kamishev
authors.forename: N S
authors.initials: NS
authors.lastname: Linkova
authors.forename: E A
authors.initials: EA
authors.lastname: Koncevaya
authors.forename: A V
authors.initials: AV
authors.lastname: Dudkov
authors.forename: L S
authors.initials: LS
authors.lastname: Kozina
authors.forename: V Kh
authors.initials: VKh
authors.lastname: Khavinson
authors.forename: Yu S
authors.initials: YS
authors.lastname: Titkov
mesh_terms: D000818:Animals; D017209:Apoptosis / Q000187:drug effects*; D001516:Bees; D049109:Cell Proliferation / Q000187:drug effects*; D002478:Cells, Cultured; D003214:Conditioning, Classical / Q000187:drug effects* / Q000502:physiology; D004703:Endocrine System / Q000187:drug effects* / Q000502:physiology; D005247:Feeding Behavior / Q000187:drug effects*; D007091:Image Processing, Computer-Assisted; D007150:Immunohistochemistry; D008297:Male; D015213:Neuroimmunomodulation / Q000187:drug effects* / Q000502:physiology; D009812:Odorants; D009842:Oligopeptides / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D018709:Statistics, Nonparametric
chemical_list: D009842:Oligopeptides; C533570:lysyl-glutamyl-aspartic acid