title: Ohno's hypothesis and Muller's paradox: sex chromosome dosage compensation may serve collective gene functions.
abstract: Muller found halving gene dosage, as in males with one X chromosome, did not affect specific gene function. Why then was dosage "compensated?" This paradox was solved by invoking collective gene functions such as self/not self discrimination afforded by protein aggregation pressure. This predicts female susceptibility to autoimmune disease.
authors.affiliation: Department of Biomedical and Molecular Sciences, Queen's University, Kingston, Ontario, Canada. forsdyke@queensu.ca
authors.forename: Donald R
authors.initials: DR
authors.lastname: Forsdyke
mesh_terms: D000818:Animals; D005075:Biological Evolution; D004303:Dosage Compensation, Genetic; D018628:Gene Dosage; D005796:Genes / Q000235:genetics*; D006801:Humans; D008957:Models, Genetic; D012730:Sex Chromosomes / Q000235:genetics*