title: Crohn's disease susceptibility genes are associated with leprosy in the Vietnamese population.
abstract: A genomewide association study in Chinese patients with leprosy detected association signals in 16 single-nucleotide polymorphisms (SNPs) belonging to 6 loci, of which 4 are related to the NOD2 signaling pathway and are Crohn's disease susceptibility loci. Here, we studied these 16 SNPs as potential leprosy susceptibility factors in 474 Vietnamese leprosy simplex families. We replicated SNPs at HLA-DR-DQ, RIPK2, CCDC122-LACC1, and NOD2 as leprosy susceptibility factors in Vietnam. These results validated the striking overlap in the genetic control of Crohn's disease and leprosy.
authors.affiliation: Laboratoire de Génétique des Maladies Infectieuses, Institut National de la Santé et de la Recherche Médicale, University Paris Descartes, Sorbonne Paris Cité, Necker Medical School, Paris, France.
authors.forename: Audrey V
authors.initials: AV
authors.lastname: Grant
authors.forename: Andrea
authors.initials: A
authors.lastname: Alter
authors.forename: Nguyen Thu
authors.initials: NT
authors.lastname: Huong
authors.forename: Marianna
authors.initials: M
authors.lastname: Orlova
authors.forename: Nguyen
authors.initials: N
authors.lastname: Van Thuc
authors.forename: Nguyen Ngoc
authors.initials: NN
authors.lastname: Ba
authors.forename: Vu Hong
authors.initials: VH
authors.lastname: Thai
authors.forename: Laurent
authors.initials: L
authors.lastname: Abel
authors.forename: Erwin
authors.initials: E
authors.lastname: Schurr
authors.forename: Alexandre
authors.initials: A
authors.lastname: Alcais
mesh_terms: D044466:Asian People / Q000235:genetics*; D003424:Crohn Disease / Q000235:genetics*; D005190:Family; D005786:Gene Expression Regulation; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D007918:Leprosy / Q000453:epidemiology / Q000235:genetics*; D053473:Nod2 Signaling Adaptor Protein / Q000235:genetics / Q000378:metabolism; D020641:Polymorphism, Single Nucleotide; D015398:Signal Transduction; D014744:Vietnam / Q000453:epidemiology
chemical_list: C429018:NOD2 protein, human; D053473:Nod2 Signaling Adaptor Protein