title: Comparison of structural bone autografts and allografts in pediatric foot surgery.
abstract: BACKGROUND
  Autogenous bone has been the gold standard as the source for structural bone-graft material due to its osteogenic potential, nonimmunogenicity, and efficiency of incorporation. However, donor-site morbidity can lead to significant problems. Allograft bone is readily available and obviates the risks associated with bone-graft harvesting. However, its use raises concerns of disease transmission, infection, slower incorporation, and immunologic reaction. Despite these concerns, allograft use has become widespread. The few comparative studies of the 2 graft types used in spine and tumor surgery are promising. We sought to compare the speed and completeness of graft incorporation and the relative safety of autograft and allograft structural bone in pediatric foot surgery.
  
  
  METHODS
  A retrospective analysis was performed on 161 children who underwent foot surgery requiring 182 allografts and 63 autografts from 1982 to 1994. Follow-up ranged from 2 to 146 months (mean=51.4).
  
  
  RESULTS
  Graft-host union, defined as radiographic evidence of healing with a clinical lack of tenderness at graft insertion site, occurred within 12 weeks in both groups. Average time to healing in both groups was just over 7 weeks. In the allograft group, there was 1 nonunion, 3 graft displacements due to technical error requiring reoperation, and 1 partial displacement that did not require reoperation. All of these complications can be attributed to technique rather than to graft type. There were no infections or instances of disease transmission. There were no reported complications in the autograft group.
  
  
  CONCLUSIONS
  Small, structural bone allografts provide a safe, efficient, and cost-effective alternative to iliac crest bone autograft in pediatric foot surgery.
  
  
  METHODS
  Level III, therapeutic study, retrospective comparative study.
authors.affiliation: Department of Orthopaedics, Seattle Children's Hospital, Seattle, WA 98015-0371, USA. ncvining@alumni.unc.edu
authors.forename: Neil C
authors.initials: NC
authors.lastname: Vining
authors.forename: Winston J
authors.initials: WJ
authors.lastname: Warme
authors.forename: Vincent S
authors.initials: VS
authors.lastname: Mosca
mesh_terms: D000293:Adolescent; D016025:Bone Transplantation / Q000009:adverse effects / Q000191:economics / Q000379:methods*; D002648:Child; D002675:Child, Preschool; D003362:Cost-Benefit Analysis; D005260:Female; D005500:Follow-Up Studies; D005530:Foot Deformities / Q000601:surgery*; D005534:Foot Diseases; D006801:Humans; D008297:Male; D012189:Retrospective Studies; D013997:Time Factors; D014182:Transplantation, Autologous; D014184:Transplantation, Homologous; D016896:Treatment Outcome; D055815:Young Adult