title: The effect of obstructive sleep apnea-hypopnea syndrome on acute myocardial infarction.
abstract: OBJECTIVE
  Obstructive sleep apnea-hypopnea syndrome (OSAHS) is the most clinically common type of sleep-related breathing disorders. In this study, the effect of OSAHS on ST segment elevation myocardial infarction (STEMI) was investigated.
  
  
  METHODS
  Seventy-five patients with STEMI were included in this study. The patients were divided into two groups: STEMI accompanied by OSAHS (O+) group (33 patients) and STEMI without OSAHS (O-) group (42 patients). The differences of the clinical characteristics between the two groups were compared. The relationship between oxyhemoglobin desaturation index (ODI) and Gensini Score, and the relationships between OSAHS and clinical parameters were analyzed by a regression analysis.
  
  
  RESULTS
  AMI mainly occurred from 10 pm to 6 am in the O+ group (45.5 %) and from 6 am to 2 pm in the O-group (52.3 %). The peak of serous creatine kinase (CK), high-sensitivity C-reactive protein (hs-CRP), N-terminal Pro-brain natriuretic peptide (NT-proBNP), and left ventricle end-diastolic volume index (LVEDVI) were significantly increased in the O+ group compared to the O- group, while the left ventricular ejection fraction (LVEF) were significantly decreased. The regression analysis showed that ODI was positively correlated with Gensini Score, while serous CK, hs-CRP, NT-proBNP, and OSAHS were independently associated with left ventricular insufficiency (LVI), and the incidence of LVI in O+ group was 5.8 times as O- group.
  
  
  CONCLUSIONS
  In STEMI patients with OSAHS, myocardial infarction mainly occurred from 10 pm to 6 am, and the incidence of LVI was significantly higher than STEMI patients without OSAHS (Tab. 5, Fig. 2, Ref. 26).
authors.affiliation: Department of Cardiology, Chinese PLA General Hospital, Beijing, China.
authors.forename: W
authors.initials: W
authors.lastname: Zhang
authors.forename: Y
authors.initials: Y
authors.lastname: Sun
authors.forename: T
authors.initials: T
authors.lastname: Li
authors.forename: G
authors.initials: G
authors.lastname: Zhang
authors.forename: Y
authors.initials: Y
authors.lastname: Wang
authors.forename: H
authors.initials: H
authors.lastname: Sun
mesh_terms: D000328:Adult; D000368:Aged; D015415:Biomarkers / Q000032:analysis; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000150:complications / Q000175:diagnosis / Q000503:physiopathology*; D010108:Oxyhemoglobins / Q000032:analysis; D020181:Sleep Apnea, Obstructive / Q000150:complications* / Q000503:physiopathology
chemical_list: D015415:Biomarkers; D010108:Oxyhemoglobins