title: Chemical composition and antimicrobial activity of essential oil of different parts of Seseli rigidum.
abstract: The chemical composition and antimicrobial activity of the essential oil of the Balkan endemic species Seseli rigidum Waldst. & Kit. (Apiaceae) was investigated. The monoterpene alpha-pinene was predominant in the volatile oil from aerial parts (57.4%) and fruit (23.3%). In the essential oil of the aerial parts limonene (6.7%), camphene (5.8%) and sabinene (5.5%) were also present in high amounts, and in the fruit oil, beta-phellandrene (17.4%) and sabinene (12.9%). On the contrary, the root essential oil was composed almost entirely of the polyacetylene falcarinol (88.8%). The antimicrobial activity of the root essential oil was significant against Staphylococcus aureus, S. epidermidis, Micrococcus luteus and Enterococcus faecalis (MICs 6.25-25.00 microg/mL). Volatile constituents from the root strongly inhibited the growth of methicillin-resistant strains of S. aureus (MICs 6.25-50.00 microg/mL). Anti-staphylococcal activity can be attributed to the main volatile constituent ofS. rigidum root, falcarinol.
authors.affiliation: Department of Pharmacognosy, University of Belgrade-Faculty of Pharmacy, V. Stepe 450, 11221 Belgrade, Serbia. mirasim@pharmacy.bg.ac.rs
authors.forename: Mirjana
authors.initials: M
authors.lastname: Marcetić
authors.forename: Dragana
authors.initials: D
authors.lastname: Bozić
authors.forename: Marina
authors.initials: M
authors.lastname: Milenković
authors.forename: Branislava
authors.initials: B
authors.lastname: Lakusić
authors.forename: Nada
authors.initials: N
authors.lastname: Kovacević
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000494:pharmacology*; D019661:Apiaceae / Q000737:chemistry*; D001419:Bacteria / Q000187:drug effects; D009822:Oils, Volatile / Q000737:chemistry / Q000494:pharmacology*; D035261:Plant Components, Aerial; D010938:Plant Oils / Q000737:chemistry / Q000494:pharmacology*; D018517:Plant Roots / Q000737:chemistry
chemical_list: D000900:Anti-Bacterial Agents; D009822:Oils, Volatile; D010938:Plant Oils