title: Effect of L-arginine supplementation on blood pressure in pregnant women: a meta-analysis of placebo-controlled trials.
abstract: OBJECTIVE
  A meta-analysis of placebo-controlled trials was conducted to evaluate the effect of L-arginine supplementation on blood pressure (BP) in pregnancy.
  
  
  METHODS
  Trials were searched in PubMed, Embase, and Cochrane Library. A total of five trials were included in the meta-analysis.
  
  
  RESULTS
  L-arginine supplementation exhibited a mean decrease of 3.07 mmHg (p = 0.004) for diastolic blood pressure and a mean increase of 1.23 weeks (p = 0.002) for gestation age at delivery in pregnancy, but did not reduce systolic BP (p = 0.19) as compared to placebo.
  
  
  CONCLUSIONS
  L-arginine supplementation had a significant effect of lowering diastolic blood pressure and prolonging gestation age in pregnancy.
authors.affiliation: Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education and Chinese Ministry of Public Health, Jinan, PR China.
authors.forename: Qing
authors.initials: Q
authors.lastname: Zhu
authors.forename: Xin
authors.initials: X
authors.lastname: Yue
authors.forename: Qing-Yin
authors.initials: QY
authors.lastname: Tian
authors.forename: Gaowa
authors.initials: G
authors.lastname: Saren
authors.forename: Ming-Hui
authors.initials: MH
authors.lastname: Wu
authors.forename: Yun
authors.initials: Y
authors.lastname: Zhang
authors.forename: Tong-Tao
authors.initials: TT
authors.lastname: Liu
mesh_terms: D001120:Arginine / Q000494:pharmacology / Q000627:therapeutic use*; D001794:Blood Pressure / Q000187:drug effects*; D018849:Controlled Clinical Trials as Topic; D019587:Dietary Supplements; D005260:Female; D005865:Gestational Age; D006801:Humans; D046110:Hypertension, Pregnancy-Induced / Q000188:drug therapy*; D011247:Pregnancy
chemical_list: D001120:Arginine