title: Crystallography of DNA and RNA G-quadruplex nucleic acids and their ligand complexes.
abstract: Quadruplexes are higher-order structures formed by natural guanine-rich nucleic acid sequences. They may play a role in gene regulation and in telomere function. This article focuses on the crystallization of quadruplexes and their complexes with small-molecule ligands. Protocols for successful crystallization, as used in the author's laboratory, are described in detail.
authors.affiliation: Cancer Research UK Biomolecular Structure Group, The UCL School of Pharmacy, London, United Kingdom.
authors.forename: Nancy
authors.initials: N
authors.lastname: Campbell
authors.forename: Gavin W
authors.initials: GW
authors.lastname: Collie
authors.forename: Stephen
authors.initials: S
authors.lastname: Neidle
mesh_terms: D001483:Base Sequence; D003460:Crystallization; D018360:Crystallography, X-Ray; D004247:DNA / Q000138:chemical synthesis / Q000737:chemistry*; D054856:G-Quadruplexes; D006801:Humans; D008024:Ligands; D008958:Models, Molecular; D012313:RNA / Q000138:chemical synthesis / Q000737:chemistry*; D016615:Telomere / Q000737:chemistry
chemical_list: D008024:Ligands; D012313:RNA; D004247:DNA