title: [Expression of SOX11 mRNA in mantle cell lymphoma and its clinical significance].
abstract: OBJECTIVE
  To investigate the expression level of SOX11 mRNA in mantle cell lymphoma (MCL) and other B-cell non-Hodgkin lymphoma (B-NHL) and its prognostic value in MCL.
  
  
  METHODS
  The expression level of SOX11 mRNA in 80 B-NHL patients were determined by real-time quantitative RT-PCR, GAPDH was used as internal control. The dispersion of SOX11 expression ratio of groups with different prognostic factors was described by Mann-Whitney U test.
  
  
  RESULTS
  The SOX11 mRNA expression level was 2.90 (0.75 - 4.63) in 80 B-NHL patients, and the expression level was significantly higher in MCL than that in other B-NHL (P = 0.014). The SOX11 expression level was statistically lower in the group of MCL with hyperleukocytosis, 12 trisomy, MYC amplification and therapeutic effect < PR (P = 0.042, 0.013, 0.028, 0.009) than that of MCL in other group. But SOX11 expression was not associated with MCL international prognostic index (MIPI) (P = 0.333), lactate dehydrogenase (LDH) (P = 0.790), ATM mutation (P = 0.865) and P53 deletion (P = 0.116). The progression free survival (PFS) and overall survival (OS) were significantly longer in the MCL patients with high level of SOX11 than that of other MCL patients.
  
  
  CONCLUSIONS
  There was statistically significant differences in SOX11 mRNA expression between MCL with other B-NHL. SOX11 maybe a good prognostic factor in MCL.
authors.affiliation: Institute of Hematology and Blood Diseases Hospital, CAMS & PUMC, Tianjin 300020, China.
authors.forename: Yan-ying
authors.initials: YY
authors.lastname: Wang
authors.forename: Zhen
authors.initials: Z
authors.lastname: Yu
authors.forename: Shu-hua
authors.initials: SH
authors.lastname: Yi
authors.forename: Zeng-jun
authors.initials: ZJ
authors.lastname: Li
authors.forename: Chang-hong
authors.initials: CH
authors.lastname: Li
authors.forename: Zhen-qing
authors.initials: ZQ
authors.lastname: Xie
authors.forename: Fei
authors.initials: F
authors.lastname: Li
authors.forename: Mei-rong
authors.initials: MR
authors.lastname: Zang
authors.forename: Mu
authors.initials: M
authors.lastname: Hao
authors.forename: Lu-gui
authors.initials: LG
authors.lastname: Qiu
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D015870:Gene Expression; D006801:Humans; D020522:Lymphoma, Mantle-Cell / Q000235:genetics* / Q000378:metabolism / Q000473:pathology; D008228:Lymphoma, Non-Hodgkin / Q000235:genetics / Q000473:pathology; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D012333:RNA, Messenger / Q000235:genetics; D055751:SOXC Transcription Factors / Q000235:genetics / Q000378:metabolism*
chemical_list: D012333:RNA, Messenger; C097473:SOX11 protein, human; D055751:SOXC Transcription Factors