title: Hyperglycemia secondary to consumption of cocaine and atypical antipsychotic drugs.
abstract: Drugs such as cocaine and atypical antipsychotic agents, such as olanzapine, are sometimes related to hyperglycemia. Whereas cocaine raises plasma glucose through catecholamine release, atypical antipsychotic agents mainly increase appetite and induce weight gain and the development of metabolic syndrome. Moreover, the latter group of drugs also act independently from weight gain or adiposity, due to inhibition of beta pancreatic cells and reduction of peripheral insulin action. We present the case of a 29-year-old non-diabetic woman with severe acute hyperglycemia in the context of a suicide attempt through intake of olanzapine and cocaine. After discontinuation of olanzapine and cocaine consumption, glycemia was immediately normalized without subsequent diagnosis of diabetes.
authors.affiliation: Servicio de Endocrinología y Nutrición. Hospital Clínico Universitario de Valencia. Valencia. España. Electronic address: carlosargente@hotmail.com.
authors.forename: Carlos R
authors.initials: CR
authors.lastname: Argente Villaplana
authors.forename: Miguel
authors.initials: M
authors.lastname: Civera Andrés
authors.forename: José T
authors.initials: JT
authors.lastname: Real Collado
authors.forename: Sergio
authors.initials: S
authors.lastname: Martínez-Hervás
authors.forename: Juan F
authors.initials: JF
authors.lastname: Ascaso Gimilio
authors.forename: Rafael
authors.initials: R
authors.lastname: Carmena Rodríguez