title: Clinical and histologic predictors of voice and disease outcome in patients with early glottic cancer.
abstract: OBJECTIVE
  To determine preliminarily if clinical or histological features of patients with laryngeal dysplasia/early carcinoma correlate with voice and disease outcomes.
  
  
  METHODS
  Retrospective case series.
  
  
  METHODS
  All UCSF Voice Center patients treated with endoscopic surgery for severe dysplasia or early laryngeal cancer between 2004 and 2010 were identified. Preoperative stroboscopy, intraoperative appearance, and histologic characteristics (pattern of invasion, degree of inflammation, and degree of keratinization) of the neoplastic lesions were compared with cordectomy type and the outcomes of voice quality and disease-free interval.
  
  
  RESULTS
  Eighteen patients were evaluated. Increased stromal chronic inflammation correlated with longer disease-free interval (r(2) = 0.38). Cordectomy type correlated with both preoperative and postoperative voice parameters (r(2) = 0.42-0.68 and 0.33-0.39).
  
  
  CONCLUSIONS
  Increased stromal chronic inflammation correlates with improved disease outcome. Voice outcome correlates with the amount of tissue removed. The clinical appearance of the lesion did not correlate with disease or voice outcome.
authors.affiliation: School of Medicine, University of California, San Francisco, San Francisco, California, USA.
authors.forename: Joseph
authors.initials: J
authors.lastname: Chang
authors.forename: Tuan-Jen
authors.initials: TJ
authors.lastname: Fang
authors.forename: Katherine
authors.initials: K
authors.lastname: Yung
authors.forename: Annemieke
authors.initials: A
authors.lastname: van Zante
authors.forename: Theodore
authors.initials: T
authors.lastname: Miller
authors.forename: Soha
authors.initials: S
authors.lastname: Al-Jurf
authors.forename: Sarah
authors.initials: S
authors.lastname: Schneider
authors.forename: Mark
authors.initials: M
authors.lastname: Courey
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001706:Biopsy; D002294:Carcinoma, Squamous Cell / Q000150:complications / Q000473:pathology* / Q000601:surgery; D018572:Disease-Free Survival; D005260:Female; D005931:Glottis / Q000473:pathology*; D006801:Humans; D007822:Laryngeal Neoplasms / Q000150:complications / Q000473:pathology* / Q000601:surgery; D007827:Laryngitis / Q000150:complications; D007828:Laryngoscopy; D008297:Male; D008875:Middle Aged; D010865:Pilot Projects; D015203:Reproducibility of Results; D012189:Retrospective Studies; D016896:Treatment Outcome; D014833:Voice Quality