title: Novel therapeutic targets in depression: minocycline as a candidate treatment.
abstract: Mood disorders are marked by high rates of non-recovery, recurrence, and chronicity, which are insufficiently addressed by current therapies. Several patho-etiological models have been proposed that are not mutually exclusive and include but are not limited to the monoamine, inflammatory, neurotrophic, gliotrophic, excitatory, and oxidative stress systems. A derivative of these observations is that treatment(s) which target one or more of these mechanistic steps may be capable of mitigating, or preventing, disparate psychopathological features. Minocycline is an agent with pleiotropic properties that targets multiple proteins and cellular processes implicated in the patho-etiology of mood disorders. Moreover, preclinical and preliminary clinical evidence suggests that minocycline possesses antidepressant properties. Herein, we provide the rationale for conducting a randomized, controlled trial to test the antidepressant properties of minocycline.
authors.affiliation: Institute of Medical Science, University of Toronto, Toronto, Canada.
authors.forename: Joanna K
authors.initials: JK
authors.lastname: Soczynska
authors.forename: Rodrigo B
authors.initials: RB
authors.lastname: Mansur
authors.forename: Elisa
authors.initials: E
authors.lastname: Brietzke
authors.forename: Walter
authors.initials: W
authors.lastname: Swardfager
authors.forename: Sidney H
authors.initials: SH
authors.lastname: Kennedy
authors.forename: Hanna O
authors.initials: HO
authors.lastname: Woldeyohannes
authors.forename: Alissa M
authors.initials: AM
authors.lastname: Powell
authors.forename: Marena S
authors.initials: MS
authors.lastname: Manierka
authors.forename: Roger S
authors.initials: RS
authors.lastname: McIntyre
mesh_terms: D000818:Animals; D000928:Antidepressive Agents / Q000627:therapeutic use*; D001921:Brain / Q000187:drug effects / Q000473:pathology; D016207:Cytokines / Q000378:metabolism; D003863:Depression / Q000188:drug therapy* / Q000473:pathology; D006801:Humans; D008911:Minocycline / Q000627:therapeutic use*; D008954:Models, Biological; D009473:Neuronal Plasticity / Q000187:drug effects; D009474:Neurons / Q000187:drug effects; D018384:Oxidative Stress / Q000187:drug effects
chemical_list: D000928:Antidepressive Agents; D016207:Cytokines; D008911:Minocycline