title: Relationships of decreased lung function with metabolic syndrome and obstructive sleep apnea in Japanese males.
abstract: OBJECTIVE
  Decreased lung function as assessed by forced vital capacity (FVC) and forced expiratory volume in one second (FEV(1)) is shown to be associated with cardiovascular morbidity and mortality. Although the underlying mechanisms for this association remain unknown, metabolic syndrome and obstructive sleep apnea (OSA) may have a role. We analyzed the relationships between metabolic syndrome and OSA in a cross-sectional health survey of middle-aged male employees.
  
  
  METHODS
  In this secondary analysis, we re-analyzed the relationships of lung function determined by spirometry with metabolic syndrome and OSA based on the respiratory disturbance index (RDI) with a type 3 portable monitor.
  
  
  RESULTS
  We analyzed 273 subjects. Independent of age, body mass index (BMI) and smoking, quartiles for lower FVC and FEV(1) were associated with a higher risk of metabolic syndrome compared with quartiles for the highest FVC and FEV(1), respectively. A similar trend was observed regarding the risk associated with waist circumference, and in FVC cases, dyslipidemia. The risk of hyperglycemia was significantly higher in quartiles for the second lowest FVC and FEV(1) than in quartiles for the highest FVC and FEV(1), respectively. A significant trend for an increase in RDI was observed in accordance with quartiles for lower FVC, but not FEV(1).
  
  
  CONCLUSIONS
  There was a significant relationship between lung function impairment and metabolic syndrome through mainly abdominal obesity, partially through hyperglycemia, and also through dyslipidemia, but only with respect to restrictive lung function. Restrictive lung function was also related to OSA. This epidemiologic evidence may indicate underlying mechanisms between decreased lung function and cardiovascular risk.
authors.affiliation: Department of Respiratory Care and Sleep Control Medicine, Graduate School of Medicine, Kyoto University, Japan.
authors.forename: Chikara
authors.initials: C
authors.lastname: Yoshimura
authors.forename: Toru
authors.initials: T
authors.lastname: Oga
authors.forename: Kazuo
authors.initials: K
authors.lastname: Chin
authors.forename: Misa
authors.initials: M
authors.lastname: Takegami
authors.forename: Ken-ichi
authors.initials: K
authors.lastname: Takahashi
authors.forename: Kensuke
authors.initials: K
authors.lastname: Sumi
authors.forename: Takaya
authors.initials: T
authors.lastname: Nakamura
authors.forename: Yukiyo
authors.initials: Y
authors.lastname: Nakayama-Ashida
authors.forename: Itsunari
authors.initials: I
authors.lastname: Minami
authors.forename: Sachiko
authors.initials: S
authors.lastname: Horita
authors.forename: Yasunori
authors.initials: Y
authors.lastname: Oka
authors.forename: Tomoko
authors.initials: T
authors.lastname: Wakamura
authors.forename: Shunichi
authors.initials: S
authors.lastname: Fukuhara
authors.forename: Michiaki
authors.initials: M
authors.lastname: Mishima
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Kadotani
mesh_terms: D000328:Adult; D003430:Cross-Sectional Studies; D005541:Forced Expiratory Volume / Q000502:physiology; D006306:Health Surveys; D006801:Humans; D006943:Hyperglycemia / Q000503:physiopathology; D007564:Japan; D008168:Lung / Q000503:physiopathology*; D008297:Male; D024821:Metabolic Syndrome / Q000150:complications* / Q000208:ethnology / Q000503:physiopathology*; D008875:Middle Aged; D056128:Obesity, Abdominal / Q000503:physiopathology; D012129:Respiratory Function Tests; D012131:Respiratory Insufficiency / Q000209:etiology / Q000503:physiopathology; D020181:Sleep Apnea, Obstructive / Q000150:complications* / Q000208:ethnology / Q000503:physiopathology*; D014797:Vital Capacity / Q000502:physiology