title: Cytokine-induced cytokine production by conventional and innate lymphoid cells.
abstract: Innate immune and differentiated T cells produce signature cytokines in response to cytokine stimulation. Optimal production requires stimulation by an NF-κB inducer, most commonly an interleukin (IL)-1 family member, and a STAT activator. Usually, there is linkage between the IL-1 family member, the activated STAT and the cytokines produced: IFNγ producers respond to the IL-1 family member, IL-18 and IL-12, a STAT4 activator; IL-13 producers respond to IL-33 (although for ILC2 cells this may be replaced by IL-25) and STAT5 activators; for cells producing IL-17A or IL-22, the combination is IL-1 and a STAT3 inducer. Cytokine-induced cytokine production may have broad significance in orchestrating innate responses to distinct infectious agents and in maintaining inflammatory responses after elimination of the inciting antigen.
authors.affiliation: Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA. lguo@niaid.nih.gov
authors.forename: Liying
authors.initials: L
authors.lastname: Guo
authors.forename: Ilkka S
authors.initials: IS
authors.lastname: Junttila
authors.forename: William E
authors.initials: WE
authors.lastname: Paul
mesh_terms: D001491:Basophils / Q000276:immunology; D006801:Humans; D007113:Immunity, Innate; D007378:Interleukins / Q000096:biosynthesis / Q000276:immunology*; D008214:Lymphocytes / Q000276:immunology*; D008407:Mast Cells / Q000276:immunology; D009504:Neutrophils / Q000276:immunology
chemical_list: D007378:Interleukins