title: Postanoxic akinesia with bilateral pallidal lesions: a PET study.
abstract: A 70-year-old woman developed marked akinesia after an anoxic event related to bronchiectasia. Magnetic resonance imaging studies revealed lesions in the bilateral globus pallidus and, to a lesser extent, in the putamen. Positron emission tomography studies with (18)F-6-fluoro-L-dopa and (11)C-N-methylspiperone showed a decreased pre- and post-synaptic uptake in the striatum. Consistent with previous reports, the present case demonstrated the basal ganglia, particularly the globus pallidus, to be selectively susceptible to anoxic insults. Furthermore, a PET study indicated a disrupted presynaptic integrity of the dopaminergic terminals and decreased dopamine D(2) receptor binding, which together appear to underlie the pathophysiology of post-anoxic akinesia, at least in the present case.
authors.affiliation: Department of Neurology, School of Medicine, Fukushima Medical University, Japan. skoba-tky@umin.net
authors.forename: Shunsuke
authors.initials: S
authors.lastname: Kobayashi
authors.forename: Toshimitsu
authors.initials: T
authors.lastname: Momose
authors.forename: Masaki
authors.initials: M
authors.lastname: Sakurai
authors.forename: Ichiro
authors.initials: I
authors.lastname: Kanazawa
mesh_terms: D000368:Aged; D001987:Bronchiectasis / Q000150:complications; D018491:Dopamine Agonists / Q000627:therapeutic use; D059290:Dopaminergic Neurons / Q000502:physiology; D005260:Female; D005917:Globus Pallidus / Q000000981:diagnostic imaging* / Q000473:pathology*; D006801:Humans; D000860:Hypoxia / Q000150:complications* / Q000209:etiology; D007980:Levodopa / Q000627:therapeutic use; D008279:Magnetic Resonance Imaging; D010243:Paralysis / Q000209:etiology* / Q000473:pathology / Q000503:physiopathology; D049268:Positron-Emission Tomography; D017448:Receptors, Dopamine D2 / Q000502:physiology; D016896:Treatment Outcome
chemical_list: D018491:Dopamine Agonists; D017448:Receptors, Dopamine D2; D007980:Levodopa