title: Synthesis and Preliminary In-Vitro Cytotoxic Activity of Various Novel 4-(N-Substituted Benzothiazolyl) Amino-7-Methoxy-6-(3-Morpholinopropoxy) Quinazoline Derivatives.
abstract: A variety of 4-(N-substituted benzothiazolyl) amino-7-methoxy-6-(3-morpholinopropoxy) quinazoline were synthesized by using various N-substituted 2-amino benzothiazole, and substituted quinazoline. The structures of these compounds were confirmed by IR, Mass and 1HNMR spectral analysis. Newly synthesized compounds were tested for their In-Vitro Cytotoxic Activity using MTT assay. Results of the study indicated novel series of N-substituted (1, 3-benzothiazole)-7-methoxy-6-(3-morpholinopropoxy) quinazoline-4-yl-amine derivatives are potential class of anticancer agents.
authors.affiliation: Department of Pharmaceutical Chemistry, Shree Dhanvantary Pharmacy College, Kim, Surat, Gujarat 394110, India. gopnitk@gmail.com.
authors.forename: Nisharth
authors.initials: N
authors.lastname: Dave
authors.forename: P
authors.initials: P
authors.lastname: Gopkumar
authors.forename: Badiger M
authors.initials: BM
authors.lastname: Arvind
authors.forename: G
authors.initials: G
authors.lastname: Sridevi