title: Androgen receptor influences on body defense system via modulation of innate and adaptive immune systems: lessons from conditional AR knockout mice.
abstract: Upon insult, such as infection or tissue injury, the innate and adaptive immune systems initiate a series of responses to defend the body. Recent studies from immune cell-specific androgen receptor (AR) knockout mice demonstrated that androgen and its receptor (androgen/AR) play significant roles in both immune regulations. In the innate immunity, androgen/AR is required for generation and proper function of neutrophils; androgen/AR also regulates wound healing processes through macrophage recruitment and proinflammatory cytokine production. In adaptive immunity, androgen/AR exerts suppressive effects on development and activation of T and B cells. Removal of such suppression causes thymic enlargement and excessive export of immature B cells. Altogether, androgen/AR plays distinct roles in individual immune cells, and targeting androgen/AR may help in treatment and management of immune-related diseases.
authors.affiliation: George Whipple Laboratory for Cancer Research, University of Rochester Medical Center, Rochester, New York, USA.
authors.forename: Jiann-Jyh
authors.initials: JJ
authors.lastname: Lai
authors.forename: Kuo-Pao
authors.initials: KP
authors.lastname: Lai
authors.forename: Weiping
authors.initials: W
authors.lastname: Zeng
authors.forename: Kuang-Hsiang
authors.initials: KH
authors.lastname: Chuang
authors.forename: Saleh
authors.initials: S
authors.lastname: Altuwaijri
authors.forename: Chawnshang
authors.initials: C
authors.lastname: Chang
mesh_terms: D056704:Adaptive Immunity / Q000276:immunology*; D000818:Animals; D007113:Immunity, Innate / Q000276:immunology*; D008213:Lymphocyte Activation / Q000276:immunology; D051379:Mice; D018345:Mice, Knockout; D018448:Models, Immunological; D011944:Receptors, Androgen / Q000172:deficiency* / Q000378:metabolism; D015398:Signal Transduction
chemical_list: D011944:Receptors, Androgen