title: Malaria incidence among kidney-transplanted recipients in an endemic malaria area, Sudan.
abstract: Malaria is endemic all over Sudan. The population are at risk of malaria infection to variable degrees. Kidney-transplanted patients on maintenance immunosuppressive therapy are known to be prone to infection, but there is not enough data in the medical literature as to whether they are more susceptible to malaria infection in endemic areas. This study was conducted in the Gezira Hospital for Renal Diseases and Surgery to assess the effect of maintenance immunosuppressive therapy in renal transplantation on malaria incidence. A total of 110 individuals were enrolled: 55 were renal-transplanted patients with end-stage renal disease who received kidney transplantation at least one year earlier and were on maintenance immunosuppressive medications. The other 55 individuals were the compatible healthy group. Thorough follow-up was exercised for both groups for one year (January-December 2009). Following the World Health Organization criteria for malaria diagnosis, a total of 51 malarial attacks were reported in both the groups, 25 in the transplanted group and 26 in the controls. The incidence difference between both groups was statistically insignificant [0.76 (± 1.170) and 1.09 (± 1.917) P = 0.282 among transplanted group and control group, respectively]. Providing routine malaria prophylaxis is not required for renal transplant recipients on maintenance immunosuppressive.
authors.affiliation: Department of Nephrology, Gezira Hospital for Renal Diseases, Khartoum, Sudan. drhafize@hotmail.com
authors.forename: Mohamed E
authors.initials: ME
authors.lastname: Elsharif
authors.forename: Elfatih M
authors.initials: EM
authors.lastname: Malik
authors.forename: Mohamed E
authors.initials: ME
authors.lastname: Imam
authors.forename: Mustafa O
authors.initials: MO
authors.lastname: Omran
authors.forename: Elham G
authors.initials: EG
authors.lastname: Elsharif
mesh_terms: D000962:Antimalarials / Q000627:therapeutic use; D016022:Case-Control Studies; D004359:Drug Therapy, Combination; D019353:Endemic Diseases; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects*; D015994:Incidence; D016030:Kidney Transplantation / Q000009:adverse effects*; D008288:Malaria / Q000175:diagnosis / Q000453:epidemiology* / Q000517:prevention & control; D008297:Male; D016017:Odds Ratio; D018570:Risk Assessment; D012307:Risk Factors; D013397:Sudan / Q000453:epidemiology; D013997:Time Factors
chemical_list: D000962:Antimalarials; D007166:Immunosuppressive Agents