title: Neuroprotective effect of mesenchymal and neural stem and progenitor cells on sensorimotor recovery after brain injury.
abstract: We studied the effect of systemic administration of multipotent stem cells on impaired neurological status in rats with brain injury. It was found that transplantation of multipotent mesenchymal stromal cells of the bone marrow or human neural stem and progenitor cells to rats with local brain injury promoted recovery of the brain control over locomotor function and proprioceptive sensitivity of forelegs. The dynamics of neurological recovery was similar after transplantation of fetal neural stem and progenitor cells and multipotent mesenchymal stromal cells. Transplantation of cell cultures improved survival of experimental animals. It should be noted that administration of neural stem and progenitor cells prevented animal death not only in the acute traumatic period, but also in delayed periods.
authors.affiliation: V. I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health and Social Development of the Russian Federation, Moscow, Russia. rimpol@mail.ru
authors.forename: R A
authors.initials: RA
authors.lastname: Poltavtseva
authors.forename: D N
authors.initials: DN
authors.lastname: Silachev
authors.forename: S V
authors.initials: SV
authors.lastname: Pavlovich
authors.forename: M I
authors.initials: MI
authors.lastname: Kesova
authors.forename: K N
authors.initials: KN
authors.lastname: Yarygin
authors.forename: A Yu
authors.initials: AY
authors.lastname: Lupatov
authors.forename: L V
authors.initials: LV
authors.lastname: Van'ko
authors.forename: M P
authors.initials: MP
authors.lastname: Shuvalova
authors.forename: G T
authors.initials: GT
authors.lastname: Sukhikh
mesh_terms: D000818:Animals; D001835:Body Weight; D001930:Brain Injuries / Q000473:pathology* / Q000628:therapy*; D064987:Cell- and Tissue-Based Therapy / Q000379:methods*; D056228:Feedback, Sensory; D006801:Humans; D008297:Male; D045164:Mesenchymal Stem Cell Transplantation; D008954:Models, Biological; D058953:Neural Stem Cells / Q000637:transplantation*; D011597:Psychomotor Performance; D051381:Rats; D018709:Statistics, Nonparametric