title: Herpes simplex viruses: mechanisms of DNA replication.
abstract: Herpes simplex virus (HSV) encodes seven proteins necessary for viral DNA synthesis-UL9 (origin-binding protein), ICP8 (single-strand DNA [ssDNA]-binding protein), UL30/UL42 (polymerase), and UL5/UL8/UL52 (helicase/primase). It is our intention to provide an up-to-date analysis of our understanding of the structures of these replication proteins and how they function during HSV replication. The potential roles of host repair and recombination proteins will also be discussed.
authors.affiliation: Department of Molecular, Microbial and Structural Biology, University of Connecticut Health Center, Farmington, Connecticut 06030-3205, USA. weller@nso2.uchc.edu
authors.forename: Sandra K
authors.initials: SK
authors.lastname: Weller
authors.forename: Donald M
authors.initials: DM
authors.lastname: Coen
mesh_terms: D004261:DNA Replication / Q000502:physiology*; D004259:DNA-Directed DNA Polymerase / Q000737:chemistry / Q000502:physiology; D016679:Genome, Viral; D008957:Models, Genetic; D017434:Protein Structure, Tertiary; D018741:Replication Origin; D018139:Simplexvirus / Q000235:genetics* / Q000502:physiology; D014764:Viral Proteins / Q000737:chemistry / Q000502:physiology*; D014779:Virus Replication / Q000502:physiology*
chemical_list: D014764:Viral Proteins; D004259:DNA-Directed DNA Polymerase