title: Phototolerance induced by narrow-band UVB phototherapy in severe erythropoietic protoporphyria.
abstract: Erythropoietic protoporphyria arises from an inherited disorder of porphyrin metabolism which leads to an accumulation of protoporphyrin IX in the erythropoietic system and other tissues. It is characterized by cutaneous photosensitivity, usually difficult to keep under control. Among the scant therapeutic options proposed to reduce photosensitivity in erythropoietic protoporphyria, narrow-band UVB phototherapy has occasionally been used to induce sunlight tolerance. We report an adult case of erythropoietic protoporphyria with a severe photosensitivity treated with narrow-band UVB that developed an appropriate sunlight phototolerance, without adverse events during phototherapy.
authors.affiliation: Dermatology Department, Hospital Universitario de La Princesa, Madrid, Spain. pgarciamartin@aedv.es
authors.forename: Patricia
authors.initials: P
authors.lastname: García-Martín
authors.forename: Diego
authors.initials: D
authors.lastname: De Argila
authors.forename: Jordi
authors.initials: J
authors.lastname: To-Figueras
authors.forename: Mar
authors.initials: M
authors.lastname: Llamas-Velasco
authors.forename: Javier
authors.initials: J
authors.lastname: Fraga
authors.forename: Amaro
authors.initials: A
authors.lastname: García-Diez
mesh_terms: D000328:Adult; D006801:Humans; D008297:Male; D010787:Photosensitivity Disorders / Q000209:etiology / Q000378:metabolism / Q000532:radiotherapy*; D017092:Porphyria, Erythropoietic / Q000150:complications / Q000378:metabolism / Q000532:radiotherapy*; D011524:Protoporphyrins / Q000378:metabolism; D013472:Sunlight / Q000009:adverse effects; D014466:Ultraviolet Rays; D014467:Ultraviolet Therapy
chemical_list: D011524:Protoporphyrins; C028025:protoporphyrin IX