title: Synthesis and pharmacological evaluation of a novel series of 3-aryl-2-(2-substituted-4-methylthiazole-5-yl)thiazolidin-4-one as possible anti-inflammatory and antimicrobial agents.
abstract: A new series of 3-aryl-2-(2-aryl/benzyl-4-methylthiazole-5-yl)thiazolidin-4-one was synthesized by condensation of 2-aryl/benzyl-4-methylthiazole-5-carbaldehyde, aromatic amines and thioglycolic acid in toluene. All the synthesized compounds are characterized by IR, NMR and elemental or mass analysis. Sixteen out of the newly synthesized compounds were screened for in vivo anti-inflammatory activity using carrageenan-induced rat paw edema method. Some of the synthesized compounds exhibited good anti-inflammatory activity compared with indomethacin. The synthesized compounds were also evaluated for their in vitro antimicrobial activity. Some of the compounds showed mild antibacterial activity while most of the compounds showed good antifungal activity.
authors.affiliation: Department of Chemistry, HPT Arts and RYK Science College, Vidyanagari, Nashik 422005, India.
authors.forename: Shivaji H
authors.initials: SH
authors.lastname: Shelke
authors.forename: Pravin C
authors.initials: PC
authors.lastname: Mhaske
authors.forename: Mukesh
authors.initials: M
authors.lastname: Nandave
authors.forename: Sachin
authors.initials: S
authors.lastname: Narkhade
authors.forename: Namdeo M
authors.initials: NM
authors.lastname: Walhekar
authors.forename: Vivek D
authors.initials: VD
authors.lastname: Bobade
mesh_terms: D000818:Animals; D000890:Anti-Infective Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D000893:Anti-Inflammatory Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects; D001424:Bacterial Infections / Q000188:drug therapy; D002351:Carrageenan; D004487:Edema / Q000139:chemically induced / Q000188:drug therapy; D005658:Fungi / Q000187:drug effects; D006801:Humans; D007213:Indomethacin / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D009181:Mycoses / Q000188:drug therapy; D051381:Rats; D013844:Thiazoles / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D053778:Thiazolidines / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*
chemical_list: D000890:Anti-Infective Agents; D000893:Anti-Inflammatory Agents; D013844:Thiazoles; D053778:Thiazolidines; D002351:Carrageenan; C410590:4-methylthiazole; D007213:Indomethacin