title: Nonenzymatic electrochemical glucose sensor based on novel Pt-Pd nanoflakes.
abstract: The sluggish kinetic-controlled glucose oxidation reaction on Pt electrodes is well recognized as the most critical issue that blocks the development and commercialization of enzyme-free glucose sensors, and increasing attention is being focused on improving the analytical performances of these nonenzymatic sensors through exploring new Pt-based catalysts. In the present research, we synthesized novel Pt-Pd nanoflakes (Pt-Pd NFs) with three-dimensional architectures on a homemade screen-printed gold film electrode (SPGFE) substrate using a facile electrochemical deposition without any template, and further investigated the properties of the as-fabricated Pt-Pd NFs/SPGFE for enzymeless glucose detection. The results reveal that the proposed Pt-Pd nanostructure can provide preeminent electrocatalytic activity and excellent selectivity for enzyme-free glucose sensing under simulative physiological conditions, mainly attributing to its attractive structure, large active surface and appropriate applied potential. The resulting Pt-Pd NFs/SPGFE offers linear current responses for glucose with the concentration upper limit to 16 mM. The obtained sensitivity is calculated to be as high as 48.0 μA cm(-2) mM(-1) in the presence of 0.15 M chlorides ions, and practical applications for blood sample analysis are also demonstrated. The proposed Pt-Pd structure is considered as a great potential building block for the fabrication of nonenzymatic electrochemical glucose sensors.
authors.affiliation: Shanghai Key Laboratory of Functional Materials Chemistry, and Research Centre of Analysis and Test, East China University of Science and Technology, Shanghai 200237, PR China.
authors.forename: Xiangheng
authors.initials: X
authors.lastname: Niu
authors.forename: Minbo
authors.initials: M
authors.lastname: Lan
authors.forename: Chen
authors.initials: C
authors.lastname: Chen
authors.forename: Hongli
authors.initials: H
authors.lastname: Zhao
mesh_terms: D002623:Chemistry Techniques, Analytical / Q000295:instrumentation*; D002712:Chlorides / Q000737:chemistry; D004563:Electrochemistry / Q000295:instrumentation / Q000379:methods*; D004566:Electrodes; D005947:Glucose / Q000032:analysis* / Q000737:chemistry; D006046:Gold / Q000737:chemistry; D053768:Metal Nanoparticles / Q000737:chemistry*; D010084:Oxidation-Reduction; D010165:Palladium / Q000737:chemistry*; D010984:Platinum / Q000737:chemistry*; D013499:Surface Properties
chemical_list: D002712:Chlorides; D010984:Platinum; D010165:Palladium; D006046:Gold; D005947:Glucose