title: Association between Serum Uric Acid Levels and Sleep Variables: Results from the National Health and Nutrition Survey 2005-2008.
abstract: Sleep disordered breathing as well as high serum uric acid levels are independent risk factors for cardiovascular disease. However, studies evaluating the relationship between sleep-disordered breathing and hyperuricemia are limited. We examined the 2005-2008 National Health and Nutrition Examination survey's sleep variables and high serum uric acid among 6491 participants aged ≥20 years. The sleep variables included sleep duration, snoring, snorting, and daytime sleepiness. The main outcome was high serum uric acid level, defined as levels of serum uric acid >6.8 mg/dL in males and >6.0 mg/dL in females. We found that snoring more than 5 nights per week, daytime sleepiness, and an additive composite score of sleep variables were associated with high serum uric acid in the age- , sex-adjusted model and in a multivariable model adjusting for demographic and lifestyle/behavioral risk factors. The association was attenuated with the addition of variables related to clinical outcomes such as depression, diabetes, hypertension, and high-cholesterol levels. Our results indicate a positive relationship between sleep variables, including the presence of snoring, snorting, and daytime sleepiness, and high serum uric acid levels.
authors.affiliation: Department of Dental Practice and Rural Health, Health Sciences North, West Virginia University, P.O. Box 9448, Morgantown, WV 26506, USA.
authors.forename: R Constance
authors.initials: RC
authors.lastname: Wiener
authors.forename: Anoop
authors.initials: A
authors.lastname: Shankar