title: Omentin-1, visfatin and adiponectin levels in relation to bone mineral density in Iranian postmenopausal women.
abstract: The bone and fat interface is implicated in the pathogenesis of postmenopausal osteoporosis. The association between circulating omentin-1 levels and bone mineral density (BMD) in postmenopausal women has never been assessed. A total of 382 healthy postmenopausal women were randomly selected. Omentin-1, visfatin, adiponectin, the receptor activator of nuclear factor-κB ligand (RANKL), osteoprotegerin, high sensitivity C-reactive protein, degradation products of C-terminal telopeptides of type I collagen, and osteocalcin were measured by highly specific enzyme-linked immunosorbent assay methods. BMD was determined for the lumbar spine (L2-L4) and the proximal femur using dual-energy X-ray absorptiometry. In multivariable-adjusted linear regression, serum omentin-1 levels were inversely correlated with BMD at the lumbar spine (β=-0.11, p=0.020). In multiple regression analyses, serum visfatin and adiponectin levels were not significantly correlated with BMD at different skeletal sites after controlling for age, body mass index, and bone-related markers. However, the highest quartile of adiponectin compared to the lowest quartile, after adjusting for potential confounders, revealed an inverse association with BMD in the lumbar spine (β=-0.19, p=0.010). In conclusion, circulating omentin-1 levels had an inverse correlation with BMD at the lumbar spine in Iranian postmenopausal women. To further understand the role of omentin-1 in bone and mineral metabolism, large-scale longitudinal studies focusing on BMD and osteoporotic fractures are warranted.
authors.affiliation: Department of Endocrine and Metabolic Diseases, The Persian Gulf Tropical Medicine Research Centre, Bushehr University of Medical Sciences, 7514763448, Bushehr, Iran.
authors.forename: Maasumeh
authors.initials: M
authors.lastname: Tohidi
authors.forename: Samad
authors.initials: S
authors.lastname: Akbarzadeh
authors.forename: Bagher
authors.initials: B
authors.lastname: Larijani
authors.forename: Mohammadreza
authors.initials: M
authors.lastname: Kalantarhormozi
authors.forename: Afshin
authors.initials: A
authors.lastname: Ostovar
authors.forename: Majid
authors.initials: M
authors.lastname: Assadi
authors.forename: Katayoun
authors.initials: K
authors.lastname: Vahdat
authors.forename: Maryam
authors.initials: M
authors.lastname: Farrokhnia
authors.forename: Zahra
authors.initials: Z
authors.lastname: Sanjdideh
authors.forename: Roya
authors.initials: R
authors.lastname: Amirinejad
authors.forename: Iraj
authors.initials: I
authors.lastname: Nabipour
mesh_terms: D015502:Absorptiometry, Photon; D052242:Adiponectin / Q000097:blood*; D000368:Aged; D000369:Aged, 80 and over; D015519:Bone Density / Q000502:physiology; D016207:Cytokines / Q000097:blood*; D005260:Female; D058851:GPI-Linked Proteins / Q000097:blood; D006801:Humans; D007492:Iran; D037102:Lectins / Q000097:blood*; D008875:Middle Aged; D054409:Nicotinamide Phosphoribosyltransferase / Q000097:blood*; D015663:Osteoporosis, Postmenopausal / Q000097:blood* / Q000378:metabolism; D017698:Postmenopause / Q000097:blood
chemical_list: C499918:ADIPOQ protein, human; D052242:Adiponectin; D016207:Cytokines; D058851:GPI-Linked Proteins; C432397:ITLN1 protein, human; D037102:Lectins; D054409:Nicotinamide Phosphoribosyltransferase