title: [How does central cornea thickness influence intraocular pressure during applanation and contour tonometry?].
abstract: BACKGROUND
  Golmann applanation tonometry represents a well-established procedure for measuring intraocular pressure (IOP). This implies the necessity of an accurate measurement of IOP with the reference tonometer. One example is the contour tonometer Pascal with a measuring probe, adapted to the cornea geometry, for measuring the IOP and the ocular pulse amplitude. There is controversy of how strongly corneal thickness affects the measurement of IOP. We thus analysed, for a number of eyes, the correlation of IOP, as measured by two types of applanation tonometers and one contour tonometer and the central corneal thickness.
  
  
  METHODS
  In all 158 patient eyes were investigated in a clinical comparison of applanation tonometers AT 870 and Ocuton-A. The study was performed by a trained ophthalmologist and the comparison was in accordance with international standard ISO 8612. In addition, the corneal thickness in the vertex was repeatedly determined using an Oculus Pentacam. The potential effect of central corneal thickness on the IOP as measured by the mentioned tonometers was statistically evaluated by rank correlation analysis.
  
  
  RESULTS
  We found that the measured IOP values for the three investigated tonometers were not normally distributed. The central corneal thickness values, in contrast, measured on 158 eyes by means of an ultrasound pachymeter and additionally on 235 eyes by the Pentacam, obeyed a Gaussian distribution. For the correlation analysis of both parameters the Spearman linear rank correlation coefficient (r) was considered. We found a very weak (|r| < 0.2) correlation between central corneal thickness and IOP for all 3 tonometers. The softness of the correlation is also illustrated by a large standard deviation of the regression line. A comparison of the different devices for corneal-thickness measurements shows less variance and a smaller variation coefficient when the ultrasoundpachymeter AL-1000 is used.
  
  
  CONCLUSIONS
  The measured values for IOP are only very weakly correlated to the central corneal thickness. For the 3 tonometer types studied there is no need to correct the indicated pressure values according to the central corneal thickness of the investigated eye. Clinical comparisons according to the ISO 8612 standard between a tonometer under test and a reference Goldmann applanation tonometer are always a time-consuming procedure. Additional measures to determine the central corneal thickness of every investigated eyes are dispensable.
authors.affiliation: thomas.schwenteck@ptb.de
authors.forename: T
authors.initials: T
authors.lastname: Schwenteck
authors.forename: M
authors.initials: M
authors.lastname: Knappe
authors.forename: I
authors.initials: I
authors.lastname: Moros
mesh_terms: D000328:Adult; D003315:Cornea / Q000033:anatomy & histology / Q000502:physiology*; D019781:Corneal Topography / Q000295:instrumentation* / Q000379:methods*; D004867:Equipment Design; D019544:Equipment Failure Analysis; D005260:Female; D006801:Humans; D007429:Intraocular Pressure / Q000502:physiology*; D008297:Male; D008365:Manometry / Q000379:methods*; D008875:Middle Aged; D009929:Organ Size; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D014065:Tonometry, Ocular / Q000295:instrumentation* / Q000379:methods*; D055815:Young Adult