title: The value of chromosomal analysis in oligozoospermic men.
abstract: OBJECTIVE
  To determine the prevalence of chromosomal abnormalities in relation to sperm concentration in subfertile oligozoospermic men.
  
  
  METHODS
  Retrospective cohort study.
  
  
  METHODS
  Two teaching hospitals.
  
  
  METHODS
  We retrospectively studied all men who received chromosomal analysis prior to intracytoplasmic sperm injection (ICSI) treatment from 2000 to 2010 in two teaching hospitals.
  
  
  METHODS
  None.
  
  
  METHODS
  The results of chromosomal analysis and semen analysis were recorded. The frequency of abnormal karyotypes was analyzed in relation to the sperm concentration, categorized as extreme oligozoospermia (>0 to ≤1 million/mL), severe oligozoospermia (>1 to ≤5 million/mL), moderate oligozoospermia (>5 to ≤20 million/mL), or normospermia (>20 million/mL).
  
  
  RESULTS
  Among 582 male ICSI candidates, the rates of abnormal karyotypes were 1.2% (2/162), 2.2% (5/227), and 1.5% (2/130) for men with extreme, severe, and moderate oligozoospermia, respectively. No abnormalities were present in normospermic men.
  
  
  CONCLUSIONS
  The risk of conceiving a viable child with unbalanced structural chromosomal abnormalities in men with oligozoospermia may not justify karyotyping.
authors.affiliation: Department of Obstetrics and Gynecology, Maxima Medical Center, Veldhoven, The Netherlands. stegencarcia@gmail.com
authors.forename: Çarcia
authors.initials: Ç
authors.lastname: Stegen
authors.forename: Minouche M E
authors.initials: MM
authors.lastname: van Rumste
authors.forename: Ben Willem J
authors.initials: BW
authors.lastname: Mol
authors.forename: Carolien A M
authors.initials: CA
authors.lastname: Koks
mesh_terms: D000328:Adult; D002869:Chromosome Aberrations / Q000706:statistics & numerical data*; D025063:Chromosome Disorders / Q000453:epidemiology* / Q000235:genetics*; D020022:Genetic Predisposition to Disease / Q000453:epidemiology* / Q000235:genetics*; D005820:Genetic Testing / Q000706:statistics & numerical data; D006801:Humans; D007621:Karyotyping / Q000706:statistics & numerical data; D008297:Male; D008875:Middle Aged; D009426:Netherlands / Q000453:epidemiology; D009845:Oligospermia / Q000453:epidemiology* / Q000235:genetics*; D015995:Prevalence; D012307:Risk Factors; D055815:Young Adult