title: Cytokines and cellular inflammatory sequence in non-athletes after prolonged exercise.
abstract: OBJECTIVE
  The goal of the study was to clarify the sequence of cytokines and inflammatory cells in non-athletes performed an intense running exercise.
  
  
  METHODS
  Sixteen young healthy men participated in the exercise trial that involved 90-min run at 65% VO2max.
  
  
  RESULTS
  The plasma concentrations of anti-inflammatory cytokines IL-4, IL-6 and IL-10 increased immediately after exercise simultaneously with number of white blood cells. Between IL-6 and IL-10, and neutrophils the relationships were observed. The correlation value for IL-6 and neutrophils was 0.775 whereas for IL-10 and neutrophils was 0.506. The proinflammatory cytokines IL-1β and TNFα were detected at 6 h after exercise and moderately correlated with monocytes count. The high level of proinflammatory cytokines, monocytes and creatine kinase (CK) remained until 48 h rest. The CK activity significantly correlated with IL-1β (r=0.578) and TNFα (r=0.452), and also with monocytes count (r=0.439).
  
  
  CONCLUSIONS
  The results have shown that: 1) exercise induces anti-inflammatory cytokines production first and then proinflammatory cytokines; and 2) prolonged proinflammatory response is closely related with muscle damage present.
authors.affiliation: Department of Sport Medicine and Biochemistry, Faculty of Physical Culture Gorzow Wlkp, University of Physical Education, Poznan, Poland. joanna.ostapiuk@gmail.com.
authors.forename: J
authors.initials: J
authors.lastname: Ostapiuk-Karolczuk
authors.forename: A
authors.initials: A
authors.lastname: Zembron-Lacny
authors.forename: M
authors.initials: M
authors.lastname: Naczk
authors.forename: M
authors.initials: M
authors.lastname: Gajewski
authors.forename: A
authors.initials: A
authors.lastname: Kasperska
authors.forename: H
authors.initials: H
authors.lastname: Dziewiecka
authors.forename: K
authors.initials: K
authors.lastname: Szyszka
mesh_terms: D000704:Analysis of Variance; D016207:Cytokines / Q000097:blood*; D005080:Exercise Test; D006801:Humans; D007249:Inflammation / Q000097:blood; D007958:Leukocyte Count; D008297:Male; D010101:Oxygen Consumption / Q000502:physiology; D012420:Running / Q000502:physiology*; D055815:Young Adult
chemical_list: D016207:Cytokines