title: Engineered nonviral nanocarriers for intracellular gene delivery applications.
abstract: The efficient delivery of nucleic acids into mammalian cells is a central aspect of cell biology and of medical applications, including cancer therapy and tissue engineering. Non-viral chemical methods have been received with great interest for transfecting cells. However, further development of nanocarriers that are biocompatible, efficient and suitable for clinical applications is still required. In this paper, the different material platforms for gene delivery are comparatively addressed, and the mechanisms of interaction with biological systems are discussed carefully.
authors.affiliation: Institut Català de Nanotecnologia, UAB Campus, 08193 Cerdanyola del Vallés, Barcelona, Spain. Isaac.Ojea@icn.cat
authors.forename: Isaac
authors.initials: I
authors.lastname: Ojea-Jiménez
authors.forename: Olivia
authors.initials: O
authors.lastname: Tort
authors.forename: Julia
authors.initials: J
authors.lastname: Lorenzo
authors.forename: Victor F
authors.initials: VF
authors.lastname: Puntes
mesh_terms: D001672:Biocompatible Materials / Q000737:chemistry*; D057005:Bioengineering; D001693:Biological Transport, Active; D002130:Calcium Phosphates / Q000737:chemistry; D048271:Chitosan / Q000737:chemistry; D050091:Dendrimers / Q000737:chemistry; D018014:Gene Transfer Techniques; D006801:Humans; D008055:Lipids / Q000737:chemistry; D008081:Liposomes / Q000737:chemistry; D058185:Magnetite Nanoparticles / Q000737:chemistry; D008422:Materials Testing; D053768:Metal Nanoparticles / Q000737:chemistry; D053769:Nanocapsules / Q000737:chemistry*; D037742:Nanotubes, Carbon / Q000737:chemistry; D009696:Nucleic Acids / Q000008:administration & dosage / Q000235:genetics; D011094:Polyethyleneimine / Q000737:chemistry; D045663:Quantum Dots; D012822:Silicon Dioxide / Q000737:chemistry
chemical_list: D001672:Biocompatible Materials; D002130:Calcium Phosphates; D050091:Dendrimers; D008055:Lipids; D008081:Liposomes; D058185:Magnetite Nanoparticles; D053769:Nanocapsules; D037742:Nanotubes, Carbon; D009696:Nucleic Acids; D012822:Silicon Dioxide; D011094:Polyethyleneimine; D048271:Chitosan; C020243:calcium phosphate