title: Dysplasia in inflammatory bowel diseases.
abstract: In both Crohn's disease and ulcerative colitis, the secondary prevention of colorectal cancer basically relies on the histological detection of dysplasia. In inflammatory bowel diseases, dysplasia identifies the subgroup of patients eligible for stricter surveillance (or prophylactic colectomy). In clinical practice, a number of issues may influence the benefits of clinico-pathological surveillance for inflammatory bowel disease patients with dysplasia, including: sampling errors, inconsistent biopsy assessments, patients' compliance with follow-up requirements, and how heath care is organized. Even in such a multifaceted context, it has been demonstrated that dysplasia surveillance is effective in reducing colorectal cancer-related mortality and morbidity. This paper focuses on current issues concerning the histological assessment of inflammatory bowel disease-associated dysplastic lesions.
authors.affiliation: Department of Medicine (DIMED), Surgical Pathology & Cytopathology Unit, University of Padova, Italy.
authors.forename: Claudia
authors.initials: C
authors.lastname: Mescoli
authors.forename: Laura
authors.initials: L
authors.lastname: Albertoni
authors.forename: Renata
authors.initials: R
authors.lastname: D'incá
authors.forename: Massimo
authors.initials: M
authors.lastname: Rugge
mesh_terms: D000230:Adenocarcinoma / Q000209:etiology / Q000473:pathology* / Q000517:prevention & control; D001706:Biopsy; D002278:Carcinoma in Situ / Q000209:etiology / Q000473:pathology* / Q000517:prevention & control; D003082:Colectomy; D003093:Colitis, Ulcerative / Q000150:complications / Q000473:pathology*; D003113:Colonoscopy; D015179:Colorectal Neoplasms / Q000209:etiology / Q000473:pathology* / Q000517:prevention & control; D003424:Crohn Disease / Q000150:complications / Q000473:pathology*; D006801:Humans; D011230:Precancerous Conditions / Q000209:etiology / Q000473:pathology*; D055502:Secondary Prevention