title: Ceria nanoparticles that can protect against ischemic stroke.
abstract: Uniform 3 nm-sized ceria nanoparticles can protect against ischemic stroke by scavenging reactive oxygen species (ROS) and reducing apoptosis. PEGylated ceria nanoparticles showed protective effects against ROS-induced cell death in vitro. Optimal doses of ceria nanoparticles reduced infarct volumes and the rate of ischemic cell death in vivo.
authors.affiliation: Department of Neurology, Seoul National University Hospital, Seoul 110-744, Korea.
authors.forename: Chi Kyung
authors.initials: CK
authors.lastname: Kim
authors.forename: Taeho
authors.initials: T
authors.lastname: Kim
authors.forename: In-Young
authors.initials: IY
authors.lastname: Choi
authors.forename: Min
authors.initials: M
authors.lastname: Soh
authors.forename: Dohoung
authors.initials: D
authors.lastname: Kim
authors.forename: Young-Ju
authors.initials: YJ
authors.lastname: Kim
authors.forename: Hyunduk
authors.initials: H
authors.lastname: Jang
authors.forename: Hye-Sung
authors.initials: HS
authors.lastname: Yang
authors.forename: Jun Yup
authors.initials: JY
authors.lastname: Kim
authors.forename: Hong-Kyun
authors.initials: HK
authors.lastname: Park
authors.forename: Seung Pyo
authors.initials: SP
authors.lastname: Park
authors.forename: Sangseung
authors.initials: S
authors.lastname: Park
authors.forename: Taekyung
authors.initials: T
authors.lastname: Yu
authors.forename: Byung-Woo
authors.initials: BW
authors.lastname: Yoon
authors.forename: Seung-Hoon
authors.initials: SH
authors.lastname: Lee
authors.forename: Taeghwan
authors.initials: T
authors.lastname: Hyeon
mesh_terms: D000818:Animals; D002545:Brain Ischemia / Q000188:drug therapy / Q000378:metabolism / Q000517:prevention & control*; D016466:CHO Cells; D016923:Cell Death / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D002563:Cerium / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology*; D006224:Cricetinae; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D016166:Free Radical Scavengers / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology*; D053768:Metal Nanoparticles / Q000008:administration & dosage / Q000737:chemistry*; D051381:Rats; D017382:Reactive Oxygen Species / Q000378:metabolism; D020521:Stroke / Q000188:drug therapy / Q000378:metabolism / Q000517:prevention & control*; D014018:Tissue Distribution
chemical_list: D016166:Free Radical Scavengers; D017382:Reactive Oxygen Species; D002563:Cerium