title: [Mother-to-child HBV transmission--atypical course of hepatitis B in an infant].
abstract: The article presents the course of hepatitis B transmitted from mother to her child. In the nine-week-pregnant mother HBsAg was not detected, but five months after delivery chronic stage hepatitis B was diagnosed. The infant was vaccinated twice against HBV without HBIG. At six months of age, the infant developed acute hepatitis B and Gianotti-Crosti syndrome (GCS) with high level of aminotransferase activity. In the 2nd year of life seroconversion in the HBe system and reduction of hepatitis B activity was observed.
  
  
  CONCLUSIONS
  1. The double HBsAg test in pregnant women may increase the detectability of HBV infection. 2. Current prophylaxis of HBV infection is not sufficient to protect mother-to-child transmission. 3. Spontaneous regression of acute hepatitis B in infants may occur in the period of more than 6 months from the onset, that is in the chronic stage.
authors.affiliation: Klinika Chorób Zakaźnych Wieku Dziecięcego Warszawskiego Uniwersytetu Medycznego, ul. Wołoska 37, 01-201 Warszawa, Poland. barbara.kowalik-mikolajewska@wum.edu.pl
authors.forename: Barbara
authors.initials: B
authors.lastname: Kowalik-Mikołajewska
authors.forename: Małgorzata
authors.initials: M
authors.lastname: Aniszewska
authors.forename: Maria
authors.initials: M
authors.lastname: Pokorska-Śpiewak
mesh_terms: D000328:Adult; D018450:Disease Progression; D005260:Female; D006509:Hepatitis B / Q000175:diagnosis* / Q000635:transmission*; D006801:Humans; D007116:Immunization, Passive; D007136:Immunoglobulins / Q000627:therapeutic use*; D007223:Infant; D007231:Infant, Newborn; D007232:Infant, Newborn, Diseases / Q000175:diagnosis* / Q000628:therapy*; D018445:Infectious Disease Transmission, Vertical; D008297:Male; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000175:diagnosis; D012074:Remission Induction
chemical_list: D007136:Immunoglobulins; C045213:hepatitis B hyperimmune globulin