title: Synthesis, characterization of (Z)-N-(1-(2-(2-amino-3-(dimethylamino) methyl)phenyl)-5-phenyl-1,3,4, oxadiazol-3(2H)-yl)ethanone analogs as potent antimicrobial and hydrogen peroxide scavenging agents.
abstract: A series of (Z)-N-(1-(2-(2-amino-3-((dimethylamino) methyl) phenyl)-5-phenyl-1,3,4,oxadiazol-3(2H)- yl)ethanone derivatives was prepared and studied for its antimicrobial and antioxidant activities. Among the synthesized derivatives, compounds (7c) (Z)-N-(1-(2-(2-amino-3-((dimethylamino)methyl)phenyl)-5-phenyl-1,3,4-oxadiazol-3(2H)- yl)ethylidene)-4-chloroaniline, (7g) (Z)-N-(1-(2-(2-amino-3-((dimethylamino)methyl)phenyl)-5-phenyl-1,3,4-oxadiazol- 3(2H)-yl)ethylidene)-4-nitroaniline and (7i) (Z)-N-(1-(2-(2-amino-3-((dimethylamino)methyl)phenyl)-5-phenyl-1,3,4- oxadiazol-3(2H)-yl)ethylidene)-4-methoxyaniline were found to be the most effective antimicrobial compounds. While the compounds 7c and 7g were the most potent antioxidant compounds with significant hydrogen peroxide scavenging activity.
authors.forename: Manav
authors.initials: M
authors.lastname: Malhotra
authors.forename: Vikramdeep
authors.initials: V
authors.lastname: Monga
authors.forename: Rajiv
authors.initials: R
authors.lastname: Sharma
authors.forename: Kapendra
authors.initials: K
authors.lastname: Sahu
authors.forename: Gaurav
authors.initials: G
authors.lastname: Sharma
authors.forename: Jainendra
authors.initials: J
authors.lastname: Jain
authors.affiliation: Department of Pharmaceutical Sciences, Maharshi Dayanand University, Rohtak-124001, India. aakashdeep82@gmail.com.
authors.forename: Aakash
authors.initials: A
authors.lastname: Deep
mesh_terms: D000890:Anti-Infective Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D016166:Free Radical Scavengers / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D006090:Gram-Negative Bacteria / Q000187:drug effects; D006094:Gram-Positive Bacteria / Q000187:drug effects; D006861:Hydrogen Peroxide / Q000737:chemistry*; D008826:Microbial Sensitivity Tests; D003904:Mitosporic Fungi / Q000187:drug effects; D015394:Molecular Structure; D010069:Oxadiazoles / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology
chemical_list: D000890:Anti-Infective Agents; D016166:Free Radical Scavengers; D010069:Oxadiazoles; C583463:1,3,4-oxadiazole; D006861:Hydrogen Peroxide