title: Inhibitory effects of Drynaria fortunei extract on house dust mite antigen-induced atopic dermatitis in NC/Nga mice.
abstract: BACKGROUND
  Drynaria fortunei (Kunze) J. Sm has been widely used in traditional medicine for the treatment of inflammation, hyperlipidemia, arteriosclerosis, rheumatism, and bone healing. We investigated the anti-inflammatory effects of a 70% ethanol extract of Drynaria fortunei (DFE).
  
  
  METHODS
  We evaluated the anti-inflammatory effects of topically applied DFE on house dust mite Dermatophargoides farinae-induced atopic dermatitis-like skin lesions in NC/Nga mice.
  
  
  RESULTS
  Treatment of NC/Nga mice with DFE reduced the dermatitis score, ear thickness, and serum levels of IgE, IgG1, and IL-6. Histopathological analyses of ear and skin lesions showed inhibition of the thickening of the epidermis and reduced epidermal/dermal infiltration of inflammatory cells. In ear lesions, mRNA expression levels of IL-4, IL-6, and tumor necrosis factor-α were reduced by DFE treatment.
  
  
  CONCLUSIONS
  DFE inhibited the development of dermatitis-like skin lesions in NC/Nga mice. These results suggest that DFE may be a therapeutic candidate for the treatment of AD.
authors.affiliation: Basic Herbal Medicine Research Group, Korea Institute of Oriental Medicine, Daejeon 305-811, Republic of Korea.
authors.forename: Yoon-Young
authors.initials: YY
authors.lastname: Sung
authors.forename: Dong-Seon
authors.initials: DS
authors.lastname: Kim
authors.forename: Won-Kyung
authors.initials: WK
authors.lastname: Yang
authors.forename: Kyoung Jin
authors.initials: KJ
authors.lastname: Nho
authors.forename: Hyeong Seok
authors.initials: HS
authors.lastname: Seo
authors.forename: Young Sang
authors.initials: YS
authors.lastname: Kim
authors.forename: Ho Kyoung
authors.initials: HK
authors.lastname: Kim
mesh_terms: D000485:Allergens / Q000276:immunology; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use*; D039741:Antigens, Dermatophagoides; D016207:Cytokines / Q000097:blood / Q000235:genetics; D003876:Dermatitis, Atopic / Q000097:blood / Q000188:drug therapy* / Q000473:pathology; D040001:Dermatophagoides farinae / Q000276:immunology; D007073:Immunoglobulin E / Q000097:blood; D007074:Immunoglobulin G / Q000097:blood; D008297:Male; D051379:Mice; D008517:Phytotherapy; D010936:Plant Extracts / Q000627:therapeutic use*; D029621:Polypodiaceae; D027343:Rhizome
chemical_list: D000485:Allergens; D000893:Anti-Inflammatory Agents; D039741:Antigens, Dermatophagoides; D016207:Cytokines; D007074:Immunoglobulin G; D010936:Plant Extracts; D007073:Immunoglobulin E