title: A case of NDM-1-producing Acinetobacter baumannii transferred from India to Japan.
abstract: A 52-year-old male Japanese businessman with massive cerebral bleeding was transferred from India to Japan and was admitted to our hospital. Multidrug-resistant Acinetobacter baumannii was isolated from his sputum. The minimum inhibitory concentrations for this strain were as follows: imipenem, 64 μg/ml; meropenem, 32 μg/ml; ciprofloxacin, 16 μg/ml; amikacin, 16 μg/ml; aztreonam, 16 μg/ml; colistin, <1 μg/ml. This A. baumannii strain had both bla NDM-1 and bla OXA-23 by polymerase chain reaction analysis. In Japan, NDM-1-producing bacteria are extremely rare in clinical specimens. To date, three NDM-1-positive cases have been detected in Japan, and this is the first case of A. baumannii-producing NDM-1 in Japan. Our case suggests that NDM-1-producing bacteria could be introduced into our country easily. There is concern that various resistant bacteria may be transferred from epidemic countries as a result of international medical care.
authors.affiliation: Department of Infection Control and Infectious Disease, Jikei University School of Medicine, 3-25-8 Nishi-shinbashi, Minatoku-ku, Tokyo, Japan. ynakazawa@jikei.ac.jp
authors.forename: Yasushi
authors.initials: Y
authors.lastname: Nakazawa
authors.forename: Ryoko
authors.initials: R
authors.lastname: Ii
authors.forename: Taku
authors.initials: T
authors.lastname: Tamura
authors.forename: Tokio
authors.initials: T
authors.lastname: Hoshina
authors.forename: Kumiko
authors.initials: K
authors.lastname: Tamura
authors.forename: Shinji
authors.initials: S
authors.lastname: Kawano
authors.forename: Tetsuro
authors.initials: T
authors.lastname: Kato
authors.forename: Fumiya
authors.initials: F
authors.lastname: Sato
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Horino
authors.forename: Masaki
authors.initials: M
authors.lastname: Yoshida
authors.forename: Seiji
authors.initials: S
authors.lastname: Hori
authors.forename: Masamitsu
authors.initials: M
authors.lastname: Sanui
authors.forename: Yoshikazu
authors.initials: Y
authors.lastname: Ishii
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Tateda
mesh_terms: D000151:Acinetobacter Infections / Q000382:microbiology*; D040981:Acinetobacter baumannii / Q000201:enzymology* / Q000235:genetics / Q000302:isolation & purification*; D000900:Anti-Bacterial Agents; D001426:Bacterial Proteins / Q000096:biosynthesis / Q000235:genetics; D006801:Humans; D007194:India; D007564:Japan; D008297:Male; D008826:Microbial Sensitivity Tests; D008875:Middle Aged; D058889:Molecular Typing; D016133:Polymerase Chain Reaction; D062486:Public Health Surveillance; D001618:beta-Lactamases / Q000096:biosynthesis* / Q000235:genetics
chemical_list: D000900:Anti-Bacterial Agents; D001426:Bacterial Proteins; D001618:beta-Lactamases; C552864:beta-lactamase NDM-1