title: Synthesis and pharmacological profile of a new selective G protein-coupled receptor 119 agonist; 6-((2-fluoro-3-(1-(3-isopropyl-1,2,4-oxadiazol-5-yl)piperidin-4-yl)propyl)amino)-2,3-dihydro-1H-inden-1-one.
abstract: 6-((2-Fluoro-3-(1-(3-isopropyl-1,2,4-oxadiazol-5-yl)piperidin-4-yl)propyl)amino)-2,3-dihydro-1H-inden-1-one is a potent drug-like G protein-coupled receptor 119 (GPR119) agonist. It is hoped that this compound would be instrumental in probing the pharmacological potential of GPR119 agonists.
authors.affiliation: Drug Discovery Laboratories, Sanwa Kagaku Kenkyusho Co., Ltd., 363 Shiosaki, Hokusei-cho, Inabe, Mie 511-0406, Japan.
authors.forename: Masao
authors.initials: M
authors.lastname: Sakairi
authors.forename: Masakazu
authors.initials: M
authors.lastname: Kogami
authors.forename: Masafumi
authors.initials: M
authors.lastname: Torii
authors.forename: Mitsuhiro
authors.initials: M
authors.lastname: Makino
authors.forename: Daisuke
authors.initials: D
authors.lastname: Kataoka
authors.forename: Ryuji
authors.initials: R
authors.lastname: Okamoto
authors.forename: Toshiyuki
authors.initials: T
authors.lastname: Miyazawa
authors.forename: Megumi
authors.initials: M
authors.lastname: Inoue
authors.forename: Naoki
authors.initials: N
authors.lastname: Takahashi
authors.forename: Satoko
authors.initials: S
authors.lastname: Harada
authors.forename: Nobuhide
authors.initials: N
authors.lastname: Watanabe
mesh_terms: D000818:Animals; D002460:Cell Line; D005951:Glucose Tolerance Test; D006801:Humans; D007192:Indenes / Q000138:chemical synthesis / Q000737:chemistry* / Q000493:pharmacokinetics / Q000494:pharmacology*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D010880:Piperidines / Q000138:chemical synthesis / Q000737:chemistry* / Q000493:pharmacokinetics / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D043562:Receptors, G-Protein-Coupled / Q000819:agonists* / Q000378:metabolism
chemical_list: C519854:GPR119 protein, human; D007192:Indenes; D010880:Piperidines; D043562:Receptors, G-Protein-Coupled