title: Xenograft enriched with autologous bone marrow in inlay reconstructions: a tomographic and histomorphometric study in rabbit calvaria.
abstract: Objective. The aim of this study was to evaluate the bone healing after the usage of a scaffold enriched with bone marrow. Study Design. Ten rabbits were divided into 2 groups of 5 animals. Bilateral 12 mm diameter defects were created in the parietal bones. In control group Bio-Oss were inserted in both defects and, in experimental group, Bio-Oss enriched with autologous bone marrow were inserted in both defects. In these two groups, one of the calvarial defects was covered with Bio-Gide. The rabbits were sacrified 8 weeks after surgery and both CT and histomorphometric analysis were done. Results. The CT showed a lower remaining defect area in the experimental group covered with Bio-Gide when compared with control group, with and without Bio-Gide. The histomorphometrics showed no difference between groups regarding the non-vital mineralized tissue area. For vital mineralized tissue area, the experimental group covered with Bio-Gide obtained a higher percentage area when compared with control group, with and without Bio-Gide. For non-mineralized tissue area, the experimental group covered with Bio-Gide obtained a lower percentage area when compared with control group, with and without Bio-Gide. Conclusion. Both autologous bone marrow and membrane can contribute to the enhancement of bone healing.
authors.affiliation: Medicine School, Unifesp, Rua Pedro de Toledo, 781-11 andar, 04039-032 São Paulo, SP, Brazil.
authors.forename: Marcelo
authors.initials: M
authors.lastname: de Oliveira E Silva
authors.forename: André Antonio
authors.initials: AA
authors.lastname: Pelegrine
authors.forename: Alexandre
authors.initials: A
authors.lastname: Alves Pinheiro da Silva
authors.forename: Luiz Roberto
authors.initials: LR
authors.lastname: Manhães Júnior
authors.forename: Rafael
authors.initials: R
authors.lastname: de Mello E Oliveira
authors.forename: Silvana
authors.initials: S
authors.lastname: Gaiba França
authors.forename: Antonio Carlos
authors.initials: AC
authors.lastname: Aloise
authors.forename: Lydia Masako
authors.initials: LM
authors.lastname: Ferreira