title: Initial In Vivo Quantification of Tc-99m Sestamibi Uptake as a Function of Tissue Type in Healthy Breasts Using Dedicated Breast SPECT-CT.
abstract: A pilot study is underway to quantify in vivo the uptake and distribution of Tc-99m Sestamibi in subjects without previous history of breast cancer using a dedicated SPECT-CT breast imaging system. Subjects undergoing diagnostic parathyroid imaging studies were consented and imaged as part of this IRB-approved breast imaging study. For each of the seven subjects, one randomly selected breast was imaged prone-pendant using the dedicated, compact breast SPECT-CT system underneath the shielded patient support. Iteratively reconstructed and attenuation and/or scatter corrected images were coregistered; CT images were segmented into glandular and fatty tissue by three different methods; the average concentration of Sestamibi was determined from the SPECT data using the CT-based segmentation and previously established quantification techniques. Very minor differences between the segmentation methods were observed, and the results indicate an average image-based in vivo Sestamibi concentration of 0.10 ± 0.16 μCi/mL with no preferential uptake by glandular or fatty tissues.
authors.affiliation: Medical Physics Graduate Program, Duke University, Durham, NC 27710, USA.
authors.forename: Steve D
authors.initials: SD
authors.lastname: Mann
authors.forename: Kristy L
authors.initials: KL
authors.lastname: Perez
authors.forename: Emily K E
authors.initials: EK
authors.lastname: McCracken
authors.forename: Jainil P
authors.initials: JP
authors.lastname: Shah
authors.forename: Terence Z
authors.initials: TZ
authors.lastname: Wong
authors.forename: Martin P
authors.initials: MP
authors.lastname: Tornai