title: The effects of aerobic training and age on plasma sICAM-1.
abstract: Chronic low-grade systemic inflammation plays a role in the development of cardiovascular (CV) disease. Habitual endurance exercise training reduces the risk of CV disease in part through anti-inflammatory mechanisms. The purpose of this study was to investigate the effects of age, endurance training status, and their interaction on pro-inflammatory plasma cytokines involved in the pathogenesis of CV disease. Subjects were BMI-matched young (25±3 years; endurance trained: n=9, sedentary: n=11) and older (62±5 years; endurance-trained: n=12, sedentary: n=11) men. Plasma cytokine concentrations were determined by multiplex cytometric bead assay. Soluble intercellular adhesion molecule-1 (sICAM-1) levels were 40% higher in sedentary older men compared to young sedentary subjects (P=0.048), but they were not different between the young and older trained men. Furthermore, sICAM-1 levels were negatively correlated with maximal oxygen uptake (V˙O2max; r= - 0.38, P=0.01) across all subjects. There were no significant differences among the groups in plasma concentrations of monocyte chemoattractant protein-1 (MCP-1), soluble tumor necrosis-α receptor (sTNFR), soluble CD40 ligand (sCD40L), or resistin. We conclude that habitual endurance training is associated with an attenuated age-related increase in plasma sICAM-1.
authors.affiliation: Children's National Medical Center, Research Center for Genetic Medicine, Washington DC, USA. gmany@cnmcresearch.org
authors.forename: G M
authors.initials: GM
authors.lastname: Many
authors.forename: N T
authors.initials: NT
authors.lastname: Jenkins
authors.forename: S
authors.initials: S
authors.lastname: Witkowski
authors.forename: J M
authors.initials: JM
authors.lastname: Damsker
authors.forename: J
authors.initials: J
authors.lastname: Hagberg
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D015415:Biomarkers / Q000097:blood; D016022:Case-Control Studies; D003430:Cross-Sectional Studies; D016207:Cytokines / Q000097:blood; D015444:Exercise / Q000502:physiology*; D005080:Exercise Test; D006801:Humans; D018799:Intercellular Adhesion Molecule-1 / Q000097:blood*; D008297:Male; D008875:Middle Aged; D010101:Oxygen Consumption; D057185:Sedentary Behavior
chemical_list: D015415:Biomarkers; D016207:Cytokines; D018799:Intercellular Adhesion Molecule-1