title: A new, highly water-soluble, fluorescent turn-on chemodosimeter for direct measurement of hydrogen sulfide in biological fluids.
abstract: A new reaction-based fluorescent reporter for H(2)S has been developed based on 8-aminopyrene-1,3,6-trisulfonate. This reporter shows high selectivity for H(2)S over other ions and thiols, and can detect H(2)S directly in serum without additives.
authors.affiliation: Department of Chemistry, Virginia Commonwealth University (VCU), 1001 W. Main St. P.O. Box 842006, Richmond, VA 23284, USA. mchartman@vcu.edu
authors.forename: Matthew C T
authors.initials: MC
authors.lastname: Hartman
authors.forename: M Michael
authors.initials: MM
authors.lastname: Dcona
mesh_terms: D001386:Azides / Q000138:chemical synthesis / Q000737:chemistry*; D002623:Chemistry Techniques, Analytical / Q000295:instrumentation*; D005456:Fluorescent Dyes / Q000138:chemical synthesis / Q000737:chemistry*; D006801:Humans; D006862:Hydrogen Sulfide / Q000097:blood* / Q000737:chemistry; D011721:Pyrenes / Q000138:chemical synthesis / Q000737:chemistry*; D012995:Solubility; D013050:Spectrometry, Fluorescence; D013451:Sulfonic Acids / Q000138:chemical synthesis / Q000737:chemistry*; D014867:Water / Q000737:chemistry*
chemical_list: C098210:1-aminopyrene-3,6,8-trisulfonic acid; C578447:8-azidopyrene-1,3,6-trisulfonic acid; D001386:Azides; D005456:Fluorescent Dyes; D011721:Pyrenes; D013451:Sulfonic Acids; D014867:Water; D006862:Hydrogen Sulfide