title: Enhanced efficacy and sensory properties of an anti-dandruff shampoo containing zinc pyrithione and climbazole.
abstract: Dandruff is a common complaint and is suffered by as much as half of the population at some time post puberty. The condition is characterized by the presence of flakes on the scalp and in the hair, and is often accompanied by itch. The most common treatment for dandruff is the use of shampoo formulations that contain fungistatic agents such as zinc pyrithione (ZPT) and octopirox. Whilst most antidandruff shampoos are effective in resolving the symptoms of dandruff these shampoos can often result in hair condition that is less than acceptable to consumers which can lead to a tendency for them to revert to use of a non-antidandruff shampoo. This can result in a rapid return of dandruff symptoms. The aim of this investigation was to study the impact of using a combination of antidandruff actives and silicones on the resolution of dandruff and to deliver superior sensory properties to the hair. We have demonstrated that shampoo containing the dual active system of ZPT/Climbazole deposits both active agents onto a model skin surface (VitroSkin) and reduces Malassezia furfur regrowth in vitro. Clinical evaluation of the dual active shampoo demonstrated superior efficacy and retained superiority during a regression phase where all subjects reverted to using a non-antidandruff shampoo. We have also demonstrated that it is possible to deposit silicone materials from antidandruff shampoo uniformly over both virgin and damaged hair fibres that results in smoother hair fibres (as evidenced by reduced dry friction). This combination of antidandruff agents and conditioning silicones delivered from a shampoo provides subjects with superior antidandruff efficacy and desired end sensory benefits ensuring compliance and longer term dandruff removal.
authors.affiliation: Unilever Research & Development Port Sunlight, Quarry Road East, Bebington, Merseyside, CH63 3JW, UK. graham.turner@unilever.com
authors.forename: G A
authors.initials: GA
authors.lastname: Turner
authors.forename: J R
authors.initials: JR
authors.lastname: Matheson
authors.forename: G-Z
authors.initials: GZ
authors.lastname: Li
authors.forename: X-Q
authors.initials: XQ
authors.lastname: Fei
authors.forename: D
authors.initials: D
authors.lastname: Zhu
authors.forename: F L
authors.initials: FL
authors.lastname: Baines
mesh_terms: D006203:Hair Preparations; D006801:Humans; D007093:Imidazoles / Q000494:pharmacology*; D009942:Organometallic Compounds / Q000494:pharmacology*; D011725:Pyridines / Q000494:pharmacology*; D013052:Spectrometry, X-Ray Emission
chemical_list: D006203:Hair Preparations; D007093:Imidazoles; D009942:Organometallic Compounds; D011725:Pyridines; C108286:climbazole; C010423:pyrithione zinc