title: A single exposure to bisphenol A alters the levels of important neuroproteins in adult male and female mice.
abstract: Bisphenol A (BPA) is widely used in polymer products in food and beverage containers, baby bottles, dental sealants and fillings, adhesives, protective coatings, flame retardants, water supply pipes, and compact discs, and is found in the environment and in placental tissue, fetuses and breast milk. We have recently reported that a single neonatal exposure to bisphenol A can induce persistent aberrations in spontaneous behavior, in a dose-dependent manner, and affect the adult response to the cholinergic agent nicotine. Furthermore, other recent reports indicate that pre- and perinatal exposure to bisphenol A can induce neurotoxic effects. The present study indicates that a single neonatal exposure to bisphenol A, on postnatal day 10, during the peak of the brain growth spurt, can alter the adult levels of proteins important for normal brain development (CaMKII and synaptophysin). These alterations are induced in both male and female mice and effects are seen in both hippocampus and cerebral cortex. These results further support our recent study showing that neonatal exposure to bisphenol A can act as a developmental neurotoxicant and the effects are similar to effects seen after a single postnatal exposure to other POPs, such as PBDEs, PCBs and PFCs.
authors.affiliation: Department of Environmental Toxicology, Uppsala University, Uppsala, Sweden. Henrik.Viberg@ebc.uu.se
authors.forename: Henrik
authors.initials: H
authors.lastname: Viberg
authors.forename: Iwa
authors.initials: I
authors.lastname: Lee
mesh_terms: D000704:Analysis of Variance; D000818:Animals; D000831:Animals, Newborn; D001559:Benzhydryl Compounds / Q000494:pharmacology*; D001921:Brain / Q000187:drug effects / Q000254:growth & development / Q000378:metabolism; D054732:Calcium-Calmodulin-Dependent Protein Kinase Type 2 / Q000378:metabolism; D004305:Dose-Response Relationship, Drug; D004968:Estrogens, Non-Steroidal / Q000494:pharmacology*; D005260:Female; D019922:GAP-43 Protein / Q000378:metabolism; D018507:Gene Expression Regulation, Developmental / Q000187:drug effects*; D008297:Male; D051379:Mice; D009419:Nerve Tissue Proteins / Q000378:metabolism*; D010636:Phenols / Q000494:pharmacology*; D011247:Pregnancy; D016708:Synaptophysin / Q000378:metabolism; D016875:tau Proteins / Q000378:metabolism; D000098826:Bisphenol A Compounds
chemical_list: D001559:Benzhydryl Compounds; D054732:Calcium-Calmodulin-Dependent Protein Kinase Type 2; D004968:Estrogens, Non-Steroidal; D019922:GAP-43 Protein; D009419:Nerve Tissue Proteins; D010636:Phenols; D016708:Synaptophysin; D016875:tau Proteins; C006780:bisphenol A; D000098826:Bisphenol A Compounds