title: Solid-in-oil dispersion: a novel core technology for drug delivery systems.
abstract: Drug delivery systems using a solid-in-oil (S/O) dispersion as a core technology have advanced significantly over the past ten years. A novel, effective and practical preparation method for a S/O dispersion was originally established in 1997 as a tool for enzymatic catalysis in organic media. This oil-based dispersion containing proteins in non-aqueous media had great potential for applications to other research with one of the most successful being its adaptation as a drug delivery system. The history and features of novel processes for preparing S/O dispersions are presented in this article. In addition, recent research into the use of S/O dispersions for innovative oral and skin drug delivery systems is discussed.
authors.affiliation: Department of Applied Chemistry, Graduate School of Engineering, Kyushu University, 744 Moto-oka, Fukuoka 819-0395, Japan.
authors.forename: Yoshiro
authors.initials: Y
authors.lastname: Tahara
authors.forename: Noriho
authors.initials: N
authors.lastname: Kamiya
authors.forename: Masahiro
authors.initials: M
authors.lastname: Goto
mesh_terms: D000279:Administration, Cutaneous; D000284:Administration, Oral; D002626:Chemistry, Pharmaceutical; D003102:Colloids; D016503:Drug Delivery Systems; D009821:Oils; D004364:Pharmaceutical Preparations / Q000008:administration & dosage / Q000737:chemistry
chemical_list: D003102:Colloids; D009821:Oils; D004364:Pharmaceutical Preparations