title: Development of pneumococcal mastoiditis due to multidrug-resistant serotype 19A despite three doses of 13-valent pneumococcal vaccine.
abstract: Acute mastoiditis is a potential complication of acute otitis media (AOM), with Streptococcus pneumoniae historically the most common pathogen isolated. Following the release of the 7-valent pneumococcal conjugate vaccine in 2000, a marked decline in invasive pneumococcal disease and a smaller reduction in pneumococcal AOM were observed, but data regarding its impact on acute mastoiditis are limited. With the recent introduction of the 13-valent pneumococcal conjugate vaccine (PCV13), it is anticipated that pneumococcal AOM and invasive disease will further diminish. We report a case of acute mastoiditis from a multidrug-resistant serotype 19A S. pneumoniae in an immunocompetent child who had received three PCV13 vaccinations.
authors.affiliation: Department of Pediatric Infectious Diseases, F. Edward Hebert School of Medicine, Uniformed Services University of the Health Sciences, 4301 Jones Bridge Rd, Bethesda, MD 20814, United States. richard.ruck@us.army.mil
authors.forename: Richard C
authors.initials: RC
authors.lastname: Ruck
authors.forename: Matthew D
authors.initials: MD
authors.lastname: Eberly
mesh_terms: D000208:Acute Disease; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D003131:Combined Modality Therapy; D024901:Drug Resistance, Multiple, Bacterial; D005260:Female; D005334:Fever / Q000175:diagnosis / Q000209:etiology; D005500:Follow-Up Studies; D006801:Humans; D007223:Infant; D008417:Mastoiditis / Q000382:microbiology* / Q000503:physiopathology / Q000628:therapy*; D008826:Microbial Sensitivity Tests; D008876:Middle Ear Ventilation / Q000379:methods; D011008:Pneumococcal Infections / Q000175:diagnosis / Q000517:prevention & control*; D022242:Pneumococcal Vaccines / Q000008:administration & dosage*; D018570:Risk Assessment; D012703:Serotyping; D012720:Severity of Illness Index; D013296:Streptococcus pneumoniae / Q000145:classification / Q000187:drug effects*; D013997:Time Factors; D016896:Treatment Outcome; D018074:Vaccines, Conjugate / Q000008:administration & dosage
chemical_list: C538862:13-valent pneumococcal vaccine; D000900:Anti-Bacterial Agents; D022242:Pneumococcal Vaccines; D018074:Vaccines, Conjugate