title: Furandiones from an endophytic Aspergillus terreus residing in Malus halliana.
abstract: Two new furandiones named asperterone B (1) and C (2) together with four known metabolites (3-6) were isolated from the liquid culture of the endophytic fungus Aspergillus terreus MHL-P22 residing in the fresh leaves of Malus halliana. The structures of the new compounds were elucidated by analysis of their MS, IR, 1D- and 2D-NMR spectra. 1 and 2 showed moderate cytotoxic activities against human colorectal carcinoma SW1116 cells with IC(50) values of 57.5 and 71.0 µM, respectively. The biosynthetic pathway for 1, 2 and their analogues was also postulated and briefly discussed.
authors.affiliation: College of Chemical Engineering, Nanjing Forestry University, 159 Longpan Road, Nanjing 210037, P R China. njguwen@163.com
authors.forename: Wen
authors.initials: W
authors.lastname: Gu
authors.forename: Chao
authors.initials: C
authors.lastname: Qiao
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D001230:Aspergillus / Q000737:chemistry* / Q000302:isolation & purification; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D015179:Colorectal Neoplasms / Q000188:drug therapy; D005663:Furans / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D006801:Humans; D020128:Inhibitory Concentration 50; D009682:Magnetic Resonance Spectroscopy; D027845:Malus / Q000382:microbiology*; D013058:Mass Spectrometry; D018515:Plant Leaves / Q000382:microbiology; D013055:Spectrophotometry, Infrared
chemical_list: D000970:Antineoplastic Agents; D005663:Furans; C554909:asperterone