title: From A1 to A3 en passant through A(2A) receptors in the hippocampus: pharmacological implications.
abstract: The role of A1 and A3 receptors is discussed based on data almost exclusively obtained in the hippocampus. This brain area, where A1 receptor expression predominates, has been a matter of intensive research in the adenosine field. Interestingly, in the last decade, the relevance of the much less expressed adenosine receptor in the hippocampus, the A2A receptor, has been put forward. These two high affinity receptors operate as effective regulators of a number of neurotransmitters and/or neuromodulators, through modulation of their release, action, or even inactivation. Therefore, A1 and A2A receptors constitute a must in the discussion about adenosine receptors in the hippocampus, and consequently, about the potential implications of their pharmacological manipulation and drug targeting.
authors.affiliation: Institute of Pharmacology and Neurosciences, Faculty of Medicine, and Unit of Neurosciences, Institute of Molecular Medicine, Av. Prof. Egas Moniz, 1649-028 Lisbon, Portugal.
authors.forename: Ana M
authors.initials: AM
authors.lastname: Sebastiao
authors.forename: Filipa F
authors.initials: FF
authors.lastname: Ribeiro
authors.forename: Joaquim A
authors.initials: JA
authors.lastname: Ribeiro
mesh_terms: D000241:Adenosine / Q000378:metabolism*; D000818:Animals; D018698:Glutamic Acid / Q000378:metabolism; D006624:Hippocampus / Q000378:metabolism*; D006801:Humans; D043682:Receptor, Adenosine A1 / Q000378:metabolism / Q000502:physiology*; D043705:Receptor, Adenosine A2A / Q000378:metabolism / Q000502:physiology*; D043684:Receptor, Adenosine A3 / Q000378:metabolism / Q000502:physiology*; D017470:Receptors, Glutamate / Q000378:metabolism
chemical_list: D043682:Receptor, Adenosine A1; D043705:Receptor, Adenosine A2A; D043684:Receptor, Adenosine A3; D017470:Receptors, Glutamate; D018698:Glutamic Acid; D000241:Adenosine