title: Hydroxyurea treatment can avoid the need for aggressive surgery in pediatric fibromatosis.
abstract: Aggressive fibromatosis is a rare tumor of borderline malignancy with a marked local aggressiveness. Surgery is the mainstay of treatment but complete tumor resection is often not easy to achieve without functional and cosmetic sequelae. We report a case of a pretreated child with aggressive fibromatosis who responded to hydroxyurea, avoiding the need for demolitive surgery.
authors.affiliation: Department of Pediatrics, Division of Hematology/Oncology, University Hospital of Padova, Padova, Italy.
authors.forename: Gianni
authors.initials: G
authors.lastname: Bisogno
authors.forename: Arianna
authors.initials: A
authors.lastname: Tagarelli
authors.forename: Roberto
authors.initials: R
authors.lastname: Stramare
authors.forename: Valeria
authors.initials: V
authors.lastname: Beltrame
authors.forename: Modesto
authors.initials: M
authors.lastname: Carli
mesh_terms: D000293:Adolescent; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D018222:Desmoid Tumors / Q000188:drug therapy* / Q000601:surgery; D006801:Humans; D006918:Hydroxyurea / Q000627:therapeutic use*; D008297:Male; D012983:Soft Tissue Neoplasms / Q000188:drug therapy* / Q000601:surgery; D013848:Thigh / Q000473:pathology
chemical_list: D000970:Antineoplastic Agents; D006918:Hydroxyurea