title: Primary results of chest wall reconstruction with polydioxanone mesh on animals.
abstract: BACKGROUND
  With the development of surgical techniques and biomedical material, increasing synthetic materials are applied to the chest wall reconstruction, such as autologous rib, muscle flap, bovine pericardium and sheet metal.
  
  
  OBJECTIVE
  To detect the safety and efficiency of synthetic material Polydioxanone (PDO) in chest wall reconstruction.
  
  
  METHODS
  Healthy adult mongrel dogs operated with PDO, and then some clinical data were collected.
  
  
  RESULTS
  Here we showed that PDO mesh could close down the function of chest wall defect, and PDO mesh could be degraded gradually and forms a fibrous layer with the surrounding tissues. Our data further demonstrated PDO mesh leads to slight lung adhesion with a small shrinkage.
  
  
  CONCLUSIONS
  These findings thus provide the first evidence that the feasibility of PDO mesh in chest wall reconstruction in dogs.
authors.affiliation: Department of Thoracic Surgery, Tongji Hospital, Tongji University School of Medicine, Shanghai, China.
authors.forename: Ruan
authors.initials: R
authors.lastname: Zheng
authors.forename: Wang
authors.initials: W
authors.lastname: Yong-Wu
authors.forename: Zhou
authors.initials: Z
authors.lastname: Yong-Xing
authors.forename: Wang
authors.initials: W
authors.lastname: Shao-Hua
mesh_terms: D000818:Animals; D001672:Biocompatible Materials; D004285:Dogs; D004867:Equipment Design; D005240:Feasibility Studies; D005260:Female; D008297:Male; D023421:Models, Animal; D016687:Polydioxanone / Q000009:adverse effects; D019651:Plastic Surgery Procedures / Q000009:adverse effects / Q000295:instrumentation*; D013526:Surgical Mesh / Q000009:adverse effects; D019616:Thoracic Surgical Procedures / Q000009:adverse effects / Q000295:instrumentation*; D035441:Thoracic Wall / Q000601:surgery*; D013997:Time Factors; D000267:Tissue Adhesions; D014945:Wound Healing
chemical_list: D001672:Biocompatible Materials; D016687:Polydioxanone