title: Wnt signaling regulates postembryonic hypothalamic progenitor differentiation.
abstract: Previous studies have raised the possibility that Wnt signaling may regulate both neural progenitor maintenance and neuronal differentiation within a single population. Here we investigate the role of Wnt/β-catenin activity in the zebrafish hypothalamus and find that the pathway is first required for the proliferation of unspecified hypothalamic progenitors in the embryo. At later stages, including adulthood, sequential activation and inhibition of Wnt activity is required for the differentiation of neural progenitors and negatively regulates radial glia differentiation. The presence of Wnt activity is conserved in hypothalamic progenitors of the adult mouse, where it plays a conserved role in inhibiting the differentiation of radial glia. This study establishes the vertebrate hypothalamus as a model for Wnt-regulated postembryonic neural progenitor differentiation and defines specific roles for Wnt signaling in neurogenesis.
authors.affiliation: Department of Neurobiology and Anatomy, University of Utah, Salt Lake City, Utah 84112, USA.
authors.forename: Xu
authors.initials: X
authors.lastname: Wang
authors.forename: Daniel
authors.initials: D
authors.lastname: Kopinke
authors.forename: Junji
authors.initials: J
authors.lastname: Lin
authors.forename: Adam D
authors.initials: AD
authors.lastname: McPherson
authors.forename: Robert N
authors.initials: RN
authors.lastname: Duncan
authors.forename: Hideo
authors.initials: H
authors.lastname: Otsuna
authors.forename: Enrico
authors.initials: E
authors.lastname: Moro
authors.forename: Kazuyuki
authors.initials: K
authors.lastname: Hoshijima
authors.forename: David J
authors.initials: DJ
authors.lastname: Grunwald
authors.forename: Francesco
authors.initials: F
authors.lastname: Argenton
authors.forename: Chi-Bin
authors.initials: CB
authors.lastname: Chien
authors.forename: L Charles
authors.initials: LC
authors.lastname: Murtaugh
authors.forename: Richard I
authors.initials: RI
authors.lastname: Dorsky
mesh_terms: D000818:Animals; D007031:Hypothalamus / Q000166:cytology* / Q000378:metabolism; D051379:Mice; D055495:Neurogenesis; D009457:Neuroglia / Q000166:cytology / Q000378:metabolism; D013234:Stem Cells / Q000166:cytology* / Q000378:metabolism; D051153:Wnt Proteins / Q000378:metabolism*; D060449:Wnt Signaling Pathway; D015027:Zebrafish / Q000196:embryology / Q000254:growth & development*
chemical_list: D051153:Wnt Proteins