title: Combinative analysis of factors influence serum alanine aminotransferase activity in adult male population from southern China.
abstract: OBJECTIVE
  Abnormal alanine aminotransferase (ALT) activity is indicative of liver disease even a burden of overall health. We assessed the factors associated with ALT activity and their internal relationships in a male population from southern China.
  
  
  METHODS
  Data of physical examinations, laboratory tests, hepatic ultrasounds and standardized questionnaire were collected from 2119 males participating in a population-based survey from September 2009 to December 2009.
  
  
  RESULTS
  Nonalcoholic fatty liver disease (NAFLD) and metabolic syndrome (MetS) were associated with the elevation of ALT levels (P<0.05). Prevalence of NAFLD was correlated to MetS (r=0.991, P=0.009). The levels of abnormal metabolic syndrome components increased in proportion with the ALT elevation (P<0.01). Obesity and hyperlipidemia were associated with the ALT levels in multivariate regression analysis (P<0.01). There was no synergic effect of hepatitis B virus surface antigen (HBsAg) and MetS on the ALT levels (synergy index [SI]=0.74, 95% confidence interval [CI]: 0.71-0.80).
  
  
  CONCLUSIONS
  NAFLD and MetS were associated with ALT levels in a male population from southern China. Obesity and hyperlipidemia were independent MetS components contributing to elevated ALT (e-ALT). This finding might suggest necessity on justification of these confounding factors when detecting ALT levels among this population.
authors.affiliation: Department of Hepatobiliary Surgery, First Affiliated Hospital of Guangxi Medical University, Nanning, 530021, Guangxi Province, China.
authors.forename: Zhengtao
authors.initials: Z
authors.lastname: Liu
authors.forename: Yanling
authors.initials: Y
authors.lastname: Hu
authors.forename: Xiaobo
authors.initials: X
authors.lastname: Yang
authors.forename: Aihua
authors.initials: A
authors.lastname: Tan
authors.forename: Yong
authors.initials: Y
authors.lastname: Gao
authors.forename: Xue
authors.initials: X
authors.lastname: Qin
authors.forename: Yu
authors.initials: Y
authors.lastname: Liang
authors.forename: Zengnan
authors.initials: Z
authors.lastname: Mo
authors.forename: Tao
authors.initials: T
authors.lastname: Peng
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000410:Alanine Transaminase / Q000097:blood*; D002681:China / Q000453:epidemiology; D005234:Fatty Liver / Q000097:blood / Q000150:complications / Q000201:enzymology; D006801:Humans; D007333:Insulin Resistance; D016015:Logistic Models; D008297:Male; D024821:Metabolic Syndrome / Q000097:blood / Q000150:complications / Q000453:epidemiology; D008875:Middle Aged; D065626:Non-alcoholic Fatty Liver Disease; D016017:Odds Ratio; D015995:Prevalence; D055815:Young Adult
chemical_list: D000410:Alanine Transaminase