title: The exportomer: the peroxisomal receptor export machinery.
abstract: Peroxisomes constitute a dynamic compartment of almost all eukaryotic cells. Depending on environmental changes and cellular demands peroxisomes can acquire diverse metabolic roles. The compartmentalization of peroxisomal matrix enzymes is a prerequisite to carry out their physiologic function. The matrix proteins are synthesized on free ribosomes in the cytosol and are ferried to the peroxisomal membrane by specific soluble receptors. Subsequent to cargo release into the peroxisomal matrix, the receptors are exported back to the cytosol to facilitate further rounds of matrix protein import. This dislocation step is accomplished by a remarkable machinery, which comprises enzymes required for the ubiquitination as well as the ATP-dependent extraction of the receptor from the membrane. Interestingly, receptor ubiquitination and dislocation are the only known energy-dependent steps in the peroxisomal matrix protein import process. The current view is that the export machinery of the receptors might function as molecular motor not only in the dislocation of the receptors but also in the import step of peroxisomal matrix protein by coupling ATP-dependent removal of the peroxisomal import receptor with cargo translocation into the organelle. In this review we will focus on the architecture and function of the peroxisomal receptor export machinery, the peroxisomal exportomer.
authors.affiliation: Abteilung für Systembiochemie, Medizinische Fakultät der Ruhr-Universität Bochum, Ruhr-Universität Bochum, Universitätsstr. 150, 44780, Bochum, Germany. harald.platta@rub.de
authors.forename: Harald W
authors.initials: HW
authors.lastname: Platta
authors.forename: Stefanie
authors.initials: S
authors.lastname: Hagen
authors.forename: Ralf
authors.initials: R
authors.lastname: Erdmann
mesh_terms: D000251:Adenosine Triphosphatases / Q000378:metabolism; D000818:Animals; D003600:Cytosol / Q000378:metabolism; D006801:Humans; D008565:Membrane Proteins / Q000378:metabolism*; D020675:Peroxisomes / Q000201:enzymology / Q000378:metabolism*; D021381:Protein Transport; D018160:Receptors, Cytoplasmic and Nuclear / Q000378:metabolism*; D012441:Saccharomyces cerevisiae / Q000378:metabolism; D029701:Saccharomyces cerevisiae Proteins / Q000378:metabolism; D054875:Ubiquitination
chemical_list: D008565:Membrane Proteins; D018160:Receptors, Cytoplasmic and Nuclear; D029701:Saccharomyces cerevisiae Proteins; D000251:Adenosine Triphosphatases