title: [Effects of di'ao xinxuekang soft capsule on lipid peroxidation and the endothelial function in patients with coronary heart disease].
abstract: OBJECTIVE
  To observe the effects of Di' ao Xinxuekang Soft Capsule (DK) on the plasma levels of superoxide dismutase (SOD), malondialdehyde (MDA), nitric oxide (NO), and endothelin (ET) in patients with coronary heart disease (CHD), and to study its underlying mechanisms.
  
  
  METHODS
  Totally 100 patients with CHD confirmed by coronary angiography were randomly assigned to two groups, the control group (60 cases) and the DK treatment group (40 cases). Patients in the control group received conventional therapy, while those in the DK treatment group received DK additionally. The therapeutic course for all was 3 months. The plasma levels of SOD, MDA, ET, and NO were determined pre-treatment, 4, 8, and 12 weeks after treatment.
  
  
  RESULTS
  Compared with before treatment, the serum levels of SOD and NO increased and the levels of MDA and ET decreased at each time point. Besides, better effects were obtained in the DK treatment group (P < 0.05).
  
  
  CONCLUSIONS
  DK possibly played a role in inhibiting lipid peroxidation and improving the endothelial dysfunction.
authors.affiliation: Department of Cardiology, Affiliated Hospital of Zunyi Medical College, Guizhou.
authors.forename: Zheng-Long
authors.initials: ZL
authors.lastname: Wang
authors.forename: Bei
authors.initials: B
authors.lastname: Shi
authors.forename: Zhi-Jiang
authors.initials: ZJ
authors.lastname: Liu
mesh_terms: D000368:Aged; D003327:Coronary Disease / Q000188:drug therapy* / Q000378:metabolism*; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D016232:Endothelins / Q000097:blood; D004730:Endothelium, Vascular / Q000503:physiopathology*; D005260:Female; D006801:Humans; D015227:Lipid Peroxidation; D008297:Male; D008315:Malondialdehyde / Q000097:blood; D008875:Middle Aged; D009569:Nitric Oxide / Q000097:blood; D008517:Phytotherapy; D013482:Superoxide Dismutase / Q000097:blood
chemical_list: D004365:Drugs, Chinese Herbal; D016232:Endothelins; D009569:Nitric Oxide; D008315:Malondialdehyde; D013482:Superoxide Dismutase