title: An efficient thiol-ene chemistry for the preparation of amphiphilic PHA-based graft copolymers.
abstract: We present a straightforward method to prepare amphiphilic graft copolymers consisting of hydrophobic poly(3-hydroxyalkanoates) (PHAs) backbone and hydrophilic α-amino-ω-methoxy poly(oxyethylene-co-oxypropylene) (Jeffamine®) units. Poly(3-hydroxyoctanoate)-co-(3-hydroxyundecenoate) (PHOU) was first methanolyzed to obtain the desired molar mass. The amino end groups of Jeffamine were converted into thiol by a reaction with N-acetylhomocysteine thiolactone and subsequently photografted. This "one-pot" functionalization prevents from arduous and time-consuming functionalization of the hydrophilic precursor or tedious modifications of PHAs, thus simplifying the process. The amphiphilic nature of modified PHAs leads to water-soluble copolymers exhibiting thermoresponsive behavior.
authors.affiliation: Institut de Chimie et des Matériaux Paris-Est (ICMPE), Systèmes Polymères, Complexes, UMR-CNRS 7182, 2-8 rue Henri Dunant, 94320 Thiais, France.
authors.forename: Gaëlle
authors.initials: G
authors.lastname: Le Fer
authors.forename: Julien
authors.initials: J
authors.lastname: Babinot
authors.forename: Davy-Louis
authors.initials: DL
authors.lastname: Versace
authors.forename: Valérie
authors.initials: V
authors.lastname: Langlois
authors.forename: Estelle
authors.initials: E
authors.lastname: Renard
mesh_terms: D000588:Amines / Q000737:chemistry; D057927:Hydrophobic and Hydrophilic Interactions; D011108:Polymers / Q000138:chemical synthesis / Q000737:chemistry*; D013438:Sulfhydryl Compounds / Q000737:chemistry*; D014867:Water / Q000737:chemistry
chemical_list: D000588:Amines; D011108:Polymers; D013438:Sulfhydryl Compounds; D014867:Water