title: Secondary metabolites from the unripe pulp of Persea americana and their antimycobacterial activities.
abstract: The fruits of Persea americana (Avocado) are nowadays used as healthy fruits in the world. Bioassay-guided fractionation of the active ethyl acetate soluble fraction has led to the isolation of five new fatty alcohol derivatives, avocadenols A-D (1-4) and avocadoin (5) from the unripe pulp of P. americana, along with 12 known compounds (6-17). These structures were elucidated by spectroscopic analysis. Among the isolates, avocadenol A (1), avocadenol B (2), (2R,4R)-1,2,4-trihydroxynonadecane (6), and (2R,4R)-1,2,4-trihydroxyheptadec-16-ene (7) showed antimycobacterial activity against Mycobacterium tuberculosis H(37)R(V)in vitro, with MIC values of 24.0, 33.8, 24.9, and 35.7 μg/ml, respectively.
authors.affiliation: Graduate Institute of Natural Products, College of Pharmacy, Kaohsiung Medical University, Kaohsiung, Taiwan 807, Taiwan, ROC.
authors.forename: Ying-Chen
authors.initials: YC
authors.lastname: Lu
authors.forename: Hsun-Shuo
authors.initials: HS
authors.lastname: Chang
authors.forename: Chien-Fang
authors.initials: CF
authors.lastname: Peng
authors.forename: Chu-Hung
authors.initials: CH
authors.lastname: Lin
authors.forename: Ih-Sheng
authors.initials: IS
authors.lastname: Chen
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000378:metabolism* / Q000494:pharmacology*; D005233:Fatty Alcohols / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology; D005638:Fruit / Q000737:chemistry / Q000378:metabolism; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D009169:Mycobacterium tuberculosis / Q000187:drug effects; D027421:Persea / Q000737:chemistry* / Q000378:metabolism; D010936:Plant Extracts / Q000737:chemistry / Q000378:metabolism* / Q000494:pharmacology*
chemical_list: D000900:Anti-Bacterial Agents; D005233:Fatty Alcohols; D010936:Plant Extracts