title: Synchronous gastrointestinal stromal tumor and primary lung adenocarcinoma.
abstract: Although rare, gastrointestinal stromal tumors (GIST) are the most common mesenchymal tumors of the gastrointestinal tract. The asynchronous occurrence of other malignancies in patients with GIST during the clinical course is relatively common. However, the synchronous coexistence of GIST and lung cancer has only rarely been reported. We experienced a case of coincidental primary lung adenocarcinoma and intestinal GIST. The present case is not only of interest due to the rare coincidence of GIST and lung cancer, but also because there was an epidermal growth factor receptor gene mutation in the lung cancer and a c-kit mutation in the GIST.
authors.affiliation: The First Department of Internal Medicine, Shinshu University School of Medicine, Japan.
authors.forename: Yousuke
authors.initials: Y
authors.lastname: Wada
authors.forename: Tomonobu
authors.initials: T
authors.lastname: Koizumi
authors.forename: Toshiki
authors.initials: T
authors.lastname: Yokoyama
authors.forename: Kazuhisa
authors.initials: K
authors.lastname: Urushihata
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Yamamoto
authors.forename: Masayuki
authors.initials: M
authors.lastname: Hanaoka
authors.forename: Keishi
authors.initials: K
authors.lastname: Kubo
mesh_terms: D000230:Adenocarcinoma / Q000175:diagnosis* / Q000235:genetics / Q000628:therapy; D001932:Brain Neoplasms / Q000175:diagnosis / Q000556:secondary; D066246:ErbB Receptors / Q000235:genetics; D005260:Female; D005770:Gastrointestinal Neoplasms / Q000175:diagnosis* / Q000235:genetics / Q000628:therapy; D046152:Gastrointestinal Stromal Tumors / Q000175:diagnosis* / Q000235:genetics / Q000628:therapy; D006801:Humans; D008175:Lung Neoplasms / Q000175:diagnosis* / Q000235:genetics / Q000628:therapy; D008875:Middle Aged; D009154:Mutation / Q000235:genetics; D009378:Neoplasms, Multiple Primary / Q000175:diagnosis* / Q000235:genetics / Q000628:therapy; D010166:Palliative Care; D019009:Proto-Oncogene Proteins c-kit / Q000235:genetics
chemical_list: D066246:ErbB Receptors; D019009:Proto-Oncogene Proteins c-kit