title: Synthesis and evaluation of anticonvulsant and antidepressant activities of 5-alkoxytetrazolo[1,5-c]thieno[2,3-e]pyrimidine derivatives.
abstract: A series of 5-alkoxytetrazolo[1,5-c]thieno[2,3-e]pyrimidine derivatives were synthesized and their anticonvulsant and antidepressant activities were evaluated. Pharmacological tests showed that four of the synthesized compounds had weak anticonvulsant activity, while most of the compounds had excellent antidepressant activity. The most active compound was 5-(2,4-dichlorobenzyloxy)tetrazolo[1,5-c] thieno[2,3-e]pyrimidine, which decreased the immobility time by 51.62% at a dose of 100 mg/kg. The results of open-field tests of this compound indicated that it had no significant effects on the locomotor activity compared with the control group at the doses assayed in the forced swimming tests test. This means that the antidepressant activity detected in the FST for the compound is not the result of central nervous system stimulant properties, and further confirms its antidepressant-like effect.
authors.affiliation: College of Pharmacy, Yanbian University, No. 977 Park Road, Yanji, Jilin 133002, China.
authors.forename: Shi-Ben
authors.initials: SB
authors.lastname: Wang
authors.forename: Xian-Qing
authors.initials: XQ
authors.lastname: Deng
authors.forename: Yan
authors.initials: Y
authors.lastname: Zheng
authors.forename: Yan-Ping
authors.initials: YP
authors.lastname: Yuan
authors.forename: Zhe-Shan
authors.initials: ZS
authors.lastname: Quan
authors.forename: Li-Ping
authors.initials: LP
authors.lastname: Guan
mesh_terms: D000818:Animals; D000927:Anticonvulsants / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D000928:Antidepressive Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D008297:Male; D018782:Maze Learning / Q000187:drug effects*; D051379:Mice; D008815:Mice, Inbred Strains; D015394:Molecular Structure; D009043:Motor Activity / Q000187:drug effects*; D011743:Pyrimidines / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D012640:Seizures / Q000188:drug therapy*; D013550:Swimming; D013777:Tetrazoles / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D000927:Anticonvulsants; D000928:Antidepressive Agents; D011743:Pyrimidines; D013777:Tetrazoles