title: Long-term nonprogressor and elite controller patients who control viremia have a higher percentage of methylation in their HIV-1 proviral promoters than aviremic patients receiving highly active antiretroviral therapy.
abstract: Several factors are involved in the control of HIV transcription/replication, including epigenetic modifications at the promoter level. Analysis of the HIV long terminal repeat (LTR) methylation status in infected patients controlling viremia is scarce. Herein, we show a higher degree of DNA methylation in the 5'-LTR of long-term nonprogressor and elite controller (LTNP/EC) versus progressor patients and a positive correlation with time of infection, indicating a certain contribution of HIV LTR silencing in reducing the number of replicating viruses which may account for a delayed progression.
authors.affiliation: Fundación de Investigación Biomédica, Hospital Carlos III, Madrid, Spain.
authors.forename: Juan Antonio
authors.initials: JA
authors.lastname: Palacios
authors.forename: Teresa
authors.initials: T
authors.lastname: Pérez-Piñar
authors.forename: Carlos
authors.initials: C
authors.lastname: Toro
authors.forename: Beatriz
authors.initials: B
authors.lastname: Sanz-Minguela
authors.forename: Victoria
authors.initials: V
authors.lastname: Moreno
authors.forename: Eulalia
authors.initials: E
authors.lastname: Valencia
authors.forename: César
authors.initials: C
authors.lastname: Gómez-Hernando
authors.forename: Berta
authors.initials: B
authors.lastname: Rodés
mesh_terms: D023241:Antiretroviral Therapy, Highly Active; D019175:DNA Methylation; D044127:Epigenesis, Genetic / Q000235:genetics*; D015658:HIV Infections / Q000097:blood / Q000188:drug therapy*; D016325:HIV Long Terminal Repeat / Q000235:genetics; D020276:HIV Long-Term Survivors; D015497:HIV-1 / Q000235:genetics*; D006801:Humans; D007963:Leukocytes, Mononuclear / Q000378:metabolism / Q000821:virology; D010802:Phylogeny; D011533:Proviruses / Q000235:genetics; D014766:Viremia / Q000235:genetics / Q000517:prevention & control*