title: High antitumor activity of highly resistant salan-titanium(IV) complexes in nanoparticles: an identified active species.
abstract: A nanoformulated trinuclear hydrolysis product of a bis(alkoxo) salan-Ti(IV)  complex shows high antitumor activity, which identifies it as an active species in cells. Additional highly stable mononuclear derivatives also show high activity, when formulated into nanoparticles, thus evincing that biologically friendly Ti(IV)  can provide high cytotoxicity with controlled biological function.
authors.affiliation: Institute of Chemistry, The Hebrew University of Jerusalem, Jerusalem, 91904, Israel.
authors.forename: Sigalit
authors.initials: S
authors.lastname: Meker
authors.forename: Katrin
authors.initials: K
authors.lastname: Margulis-Goshen
authors.forename: Ester
authors.initials: E
authors.lastname: Weiss
authors.forename: Shlomo
authors.initials: S
authors.lastname: Magdassi
authors.forename: Edit Y
authors.initials: EY
authors.lastname: Tshuva
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry / Q000494:pharmacology*; D045744:Cell Line, Tumor; D056831:Coordination Complexes / Q000737:chemistry / Q000494:pharmacology*; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D008958:Models, Molecular; D053758:Nanoparticles / Q000737:chemistry / Q000627:therapeutic use*; D013329:Structure-Activity Relationship; D014025:Titanium / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D000970:Antineoplastic Agents; D056831:Coordination Complexes; D014025:Titanium