title: Laminopathies: too much SUN is a bad thing.
abstract: SUN proteins accelerate the pathological progression of laminopathies. Although the mechanisms remain to be elucidated, an intriguing possibility is that high levels of SUN proteins lead to a hyperactive DNA damage response.
authors.affiliation: Department of Molecular and Cellular Biology, University of California at Davis, CA 95616, USA. dastarr@ucdavis.edu
authors.forename: Daniel A
authors.initials: DA
authors.lastname: Starr
mesh_terms: D000818:Animals; D004249:DNA Damage; D004260:DNA Repair; D008565:Membrane Proteins / Q000502:physiology*; D008869:Microtubule-Associated Proteins / Q000502:physiology*; D034501:Telomere-Binding Proteins / Q000502:physiology*
chemical_list: D008565:Membrane Proteins; D008869:Microtubule-Associated Proteins; C464932:SUN1 protein, mouse; C520338:Sun2 protein, mouse; D034501:Telomere-Binding Proteins