title: Single-subject oscillatory γ responses in tinnitus.
abstract: This study used magnetoencephalography to record oscillatory activity in a group of 17 patients with chronic tinnitus. Two methods, residual inhibition and residual excitation, were used to bring about transient changes in spontaneous tinnitus intensity in order to measure dynamic tinnitus correlates in individual patients. In residual inhibition, a positive correlation was seen between tinnitus intensity and both delta/theta (6/14 patients) and gamma band (8/14 patients) oscillations in auditory cortex, suggesting an increased thalamocortical input and cortical gamma response, respectively, associated with higher tinnitus states. Conversely, 4/4 patients exhibiting residual excitation demonstrated an inverse correlation between perceived tinnitus intensity and auditory cortex gamma oscillations (with no delta/theta changes) that cannot be explained by existing models. Significant oscillatory power changes were also identified in a variety of cortical regions, most commonly midline lobar regions in the default mode network, cerebellum, insula and anterior temporal lobe. These were highly variable across patients in terms of areas and frequency bands involved, and in direction of power change. We suggest a model based on a local circuit function of cortical gamma-band oscillations as a process of mutual inhibition that might suppress abnormal cortical activity in tinnitus. The work implicates auditory cortex gamma-band oscillations as a fundamental intrinsic mechanism for attenuating phantom auditory perception.
authors.affiliation: Auditory Group, Institute of Neuroscience, Newcastle University Medical School, Framlington Place, Newcastle Upon Tyne NE2 4HH, UK. willsedley@gmail.com
authors.forename: William
authors.initials: W
authors.lastname: Sedley
authors.forename: Sundeep
authors.initials: S
authors.lastname: Teki
authors.forename: Sukhbinder
authors.initials: S
authors.lastname: Kumar
authors.forename: Gareth Robert
authors.initials: GR
authors.lastname: Barnes
authors.forename: Doris-Eva
authors.initials: DE
authors.lastname: Bamiou
authors.forename: Timothy David
authors.initials: TD
authors.lastname: Griffiths
mesh_terms: D000328:Adult; D001303:Auditory Cortex / Q000503:physiopathology*; D002540:Cerebral Cortex / Q000503:physiopathology*; D002908:Chronic Disease; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000295:instrumentation / Q000379:methods; D015225:Magnetoencephalography / Q000295:instrumentation / Q000379:methods*; D008297:Male; D008875:Middle Aged; D008959:Models, Neurological; D009483:Neuropsychological Tests; D014012:Tinnitus / Q000503:physiopathology*; D055815:Young Adult