title: Neuroprotective effect of sinapic acid in a mouse model of amyloid β(1-42) protein-induced Alzheimer's disease.
abstract: Sinapic acid (SA) is a phenylpropanoid compound with anti-inflammatory and neuroprotective activities. The neuroprotective effects of SA in a mouse model of amyloid β (Aβ)(1-42) protein-induced Alzheimer's disease (AD) were investigated. Mice received a bilateral injection of Aβ(1-42) protein into the hippocampus to verify the efficacy of SA. Mice were treated with SA (10mg/kg/day, p.o.) for 7days beginning immediately after Aβ(1-42) protein injection, and an acquisition trial of the passive avoidance task was conducted 1h after the last administration of SA. Retention trial was conducted 24h after the acquisition trial, and mice were sacrificed for immunohistochemistry immediately after the retention trial. SA rescued neuronal cell death in the hippocampal CA1 region and also attenuated the increase of iNOS expression, glial cell activations and nitrotyrosine expressions induced by Aβ(1-42) protein. SA significantly attenuated memory impairment in the passive avoidance task. These results suggest that SA ameliorated Aβ(1-42) protein-related pathology including neuronal cell death and cognitive dysfunction via its anti-oxidative and anti-inflammatory activities, and may be an efficacious treatment for AD.
authors.affiliation: Department of Life and Nanopharmaceutical Science, Kyung Hee University, Seoul 130-701, Republic of Korea.
authors.forename: Hyung Eun
authors.initials: HE
authors.lastname: Lee
authors.forename: Dong Hyun
authors.initials: DH
authors.lastname: Kim
authors.forename: Se Jin
authors.initials: SJ
authors.lastname: Park
authors.forename: Jong Min
authors.initials: JM
authors.lastname: Kim
authors.forename: Young Woo
authors.initials: YW
authors.lastname: Lee
authors.forename: Jun Man
authors.initials: JM
authors.lastname: Jung
authors.forename: Chang Hwan
authors.initials: CH
authors.lastname: Lee
authors.forename: Jin Gyu
authors.initials: JG
authors.lastname: Hong
authors.forename: Xiaotong
authors.initials: X
authors.lastname: Liu
authors.forename: Mudan
authors.initials: M
authors.lastname: Cai
authors.forename: Keon Ju
authors.initials: KJ
authors.lastname: Park
authors.forename: Dae Sik
authors.initials: DS
authors.lastname: Jang
authors.forename: Jong Hoon
authors.initials: JH
authors.lastname: Ryu
mesh_terms: D000544:Alzheimer Disease / Q000378:metabolism / Q000517:prevention & control*; D016229:Amyloid beta-Peptides / Q000378:metabolism*; D000818:Animals; D001362:Avoidance Learning; D015153:Blotting, Western; D003373:Coumaric Acids / Q000494:pharmacology*; D004195:Disease Models, Animal; D007150:Immunohistochemistry; D020287:In Situ Nick-End Labeling; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D010446:Peptide Fragments / Q000378:metabolism*
chemical_list: D016229:Amyloid beta-Peptides; D003373:Coumaric Acids; D010446:Peptide Fragments; C075222:amyloid beta-protein (1-42); C073734:sinapinic acid