title: Synaptic energy use and supply.
abstract: Neuronal computation is energetically expensive. Consequently, the brain's limited energy supply imposes constraints on its information processing capability. Most brain energy is used on synaptic transmission, making it important to understand how energy is provided to and used by synapses. We describe how information transmission through presynaptic terminals and postsynaptic spines is related to their energy consumption, assess which mechanisms normally ensure an adequate supply of ATP to these structures, consider the influence of synaptic plasticity and changing brain state on synaptic energy use, and explain how disruption of the energy supply to synapses leads to neuropathology.
authors.affiliation: Department of Neuroscience, Physiology & Pharmacology, University College London, Gower Street, London WC1E 6BT, UK.
authors.forename: Julia J
authors.initials: JJ
authors.lastname: Harris
authors.forename: Renaud
authors.initials: R
authors.lastname: Jolivet
authors.forename: David
authors.initials: D
authors.lastname: Attwell
mesh_terms: D000818:Animals; D001921:Brain / Q000378:metabolism* / Q000502:physiology; D001923:Brain Chemistry / Q000502:physiology*; D004734:Energy Metabolism / Q000502:physiology*; D006801:Humans; D009473:Neuronal Plasticity / Q000502:physiology*; D009435:Synaptic Transmission / Q000502:physiology*