title: Isolation of lomaiviticins C-E, transformation of lomaiviticin C to lomaiviticin A, complete structure elucidation of lomaiviticin A, and structure-activity analyses.
abstract: We describe the isolation of (-)-lomaiviticins C-E (6-8), elucidation of the complete absolute and relative stereochemistry of (-)-lomaiviticin A (1), the synthetic conversion of (-)-lomaiviticin C (6) to (-)-lomaiviticin A (1), and the first evidence that the dimeric diazofluorene of (-)-lomaiviticin A (1) plays a defining and critical role in antiproliferative activity.
authors.affiliation: Department of Chemistry, Yale University, New Haven, Connecticut 06520, USA.
authors.forename: Christina M
authors.initials: CM
authors.lastname: Woo
authors.forename: Nina E
authors.initials: NE
authors.lastname: Beizer
authors.forename: Jeffrey E
authors.initials: JE
authors.lastname: Janso
authors.forename: Seth B
authors.initials: SB
authors.lastname: Herzon
mesh_terms: D005449:Fluorenes / Q000737:chemistry / Q000302:isolation & purification*; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D013329:Structure-Activity Relationship
chemical_list: D005449:Fluorenes