title: Score Study Report 12: Development of venous collaterals in the Score Study.
abstract: OBJECTIVE
  To investigate the prevalence of venous collaterals after branch and central retinal vein occlusion, assess the association of venous collaterals with other clinical features (including visual acuity), and determine if treatment with intravitreal corticosteroids influences the development of new venous collaterals.
  
  
  METHODS
  Review of data from two multicenter randomized clinical trials in the Standard of Care versus COrticosteroid for REtinal Vein Occlusion (SCORE) Study.
  
  
  RESULTS
  Statistically significant associations of venous collaterals and visual acuity at baseline or at follow-up were not found. Treatment with intravitreal triamcinolone acetonide did not appear to influence the development of venous collaterals.
  
  
  CONCLUSIONS
  In contrast to some previous reports, development of venous collaterals did not demonstrate an independent association with visual acuity in eyes with branch retinal vein occlusion or central retinal vein occlusion in the SCORE Study. Intravitreal steroid effects do not appear to influence the development of venous collaterals.
authors.affiliation: Medical College of Wisconsin, Milwaukee, Wisconsin, USA.
authors.forename: David V
authors.initials: DV
authors.lastname: Weinberg
authors.forename: Aimee E
authors.initials: AE
authors.lastname: Wahle
authors.forename: Michael S
authors.initials: MS
authors.lastname: Ip
authors.forename: Ingrid U
authors.initials: IU
authors.lastname: Scott
authors.forename: Paul C
authors.initials: PC
authors.lastname: VanVeldhuisen
authors.forename: Barbara A
authors.initials: BA
authors.lastname: Blodi
mesh_terms: D003097:Collateral Circulation / Q000502:physiology*; D005260:Female; D005451:Fluorescein Angiography; D005938:Glucocorticoids / Q000008:administration & dosage / Q000627:therapeutic use; D006801:Humans; D058449:Intravitreal Injections; D008269:Macular Edema / Q000188:drug therapy / Q000503:physiopathology*; D008297:Male; D009898:Optic Disk / Q000098:blood supply; D012169:Retinal Vein / Q000502:physiology*; D012170:Retinal Vein Occlusion / Q000188:drug therapy / Q000503:physiopathology*; D041623:Tomography, Optical Coherence; D014222:Triamcinolone Acetonide / Q000008:administration & dosage / Q000627:therapeutic use; D014792:Visual Acuity / Q000502:physiology
chemical_list: D005938:Glucocorticoids; D014222:Triamcinolone Acetonide