title: Lifestyle changes in women at genetic risk of breast cancer: an observational study.
abstract: BACKGROUND
  Lifestyle influences breast cancer risk. Women at increased familial risk may benefit from modifying behaviour, but it is not known to what extent they do so.
  
  
  OBJECTIVE
  This study aims to measure changes that UK (Scottish) women make in response to increased familial risk of breast cancer and attitudes to a risk-reduction trial.
  
  
  METHODS
  A questionnaire, completed by 140 "breast cancer family" clinic patients, generated data on habitual diet, alcohol consumption and exercise, changes made after learning of breast cancer risk and attitudes to possible further changes. Subgroups of patients were defined by criteria likely to influence changes in behaviour. Between-group differences were analysed by Fisher's exact test and overall correlations by linear regression.
  
  
  RESULTS
  Thirty-six subjects (26 %) reported no behavioural change but, overall, around 25 % of diet, exercise and alcohol items had been changed. Women perceiving their lifetime cancer risk to be high (>50 %) and those who were obese (BMI >25) had made significantly more changes than others. Younger women (<40 years) and those with daughters had made fewer changes. Almost all suggested elements of a risk-reduction trial were strongly supported.
  
  
  CONCLUSIONS
  Scottish women at increased risk of breast cancer have scope for protective changes in lifestyle and support a risk-reduction trial. The needs of younger women and of those with daughters should be addressed in its design.
authors.affiliation: Department of Clinical Genetics, Ninewells Hospital and Medical School, Dundee, DD1 9SY, UK.
authors.forename: Lorna
authors.initials: L
authors.lastname: McLeish
authors.forename: Marta M
authors.initials: MM
authors.lastname: Reis
authors.forename: Clare
authors.initials: C
authors.lastname: Stewart
authors.forename: David R
authors.initials: DR
authors.lastname: Goudie
authors.forename: Jonathan N
authors.initials: JN
authors.lastname: Berg
authors.forename: Michelle
authors.initials: M
authors.lastname: Harvie
authors.forename: Kirstie A
authors.initials: KA
authors.lastname: Hanning
authors.forename: Helen
authors.initials: H
authors.lastname: Vysny
authors.forename: C Michael
authors.initials: CM
authors.lastname: Steel
mesh_terms: D000328:Adult; D000428:Alcohol Drinking / Q000517:prevention & control; D001294:Attitude to Health; D001943:Breast Neoplasms / Q000235:genetics / Q000517:prevention & control*; D015444:Exercise; D005260:Female; D006801:Humans; D007389:Internal-External Control; D008019:Life Style; D008875:Middle Aged; D009765:Obesity / Q000517:prevention & control; D012044:Regression Analysis; D012307:Risk Factors; D040242:Risk Reduction Behavior; D012606:Scotland; D000074606:Smoking Prevention; D011795:Surveys and Questionnaires; D014930:Women