title: Cerebrospinal fluid S100B levels reflect symptoms of depression in patients with non-inflammatory neurological disorders.
abstract: Recent findings document numerous interactions between neuronal and glial systems that likely play a role in the pathophysiology of depression. These findings suggest that glia-derived neurotrophic protein S100B may play a significant role in developing depression. To test the relationship between S100B and depressive symptoms we designed cross-sectional clinical study including S100B serum and CSF levels in neurological patients with non-inflammatory disorders (NIND), who undergone cerebrospinal fluid assessment for diagnostic purposes. The present study was focused on psychometric testing of depression (BDI-II), anxiety (SAS) and alexithymia (TAS-20), and neurochemical measure of cerebrospinal fluid (CSF) and serum levels of S100B in 40 NIND inpatients [mean age 41.67]. The main result shows that S100B in CSF is significantly negatively correlated with BDI-II (Spearman R=-0.51, p<0.0009) but not with SAS and TAS-20. The finding indicates that decreased level of S100B in CSF is related to increased symptoms of depression in the NIND patients.
authors.affiliation: Center for Neuropsychiatric Research of Traumatic Stress, Department of Psychiatry & UHSL, 1st Faculty of Medicine, Charles University, Prague, Czech Republic. uhertomas@hotmail.com
authors.forename: Tomas
authors.initials: T
authors.lastname: Uher
authors.forename: Petr
authors.initials: P
authors.lastname: Bob
mesh_terms: D015415:Biomarkers / Q000097:blood / Q000134:cerebrospinal fluid; D003430:Cross-Sectional Studies; D003863:Depression / Q000134:cerebrospinal fluid* / Q000150:complications / Q000523:psychology; D005260:Female; D006801:Humans; D008297:Male; D009414:Nerve Growth Factors / Q000097:blood / Q000134:cerebrospinal fluid*; D009422:Nervous System Diseases / Q000134:cerebrospinal fluid* / Q000150:complications / Q000523:psychology; D011594:Psychometrics; D064568:S100 Calcium Binding Protein beta Subunit; D009418:S100 Proteins / Q000097:blood / Q000134:cerebrospinal fluid*
chemical_list: D015415:Biomarkers; D009414:Nerve Growth Factors; D064568:S100 Calcium Binding Protein beta Subunit; D009418:S100 Proteins; C579160:S100B protein, human