title: Oseltamivir-resistant influenza A(H1N1)pdm09 virus in Dutch travellers returning from Spain, August 2012.
abstract: Two Dutch travellers were infected with oseltamivir-resistant influenza A(H1N1)pdm09 viruses with an H275Y neuraminidase substitution in early August 2012. Both cases were probably infected during separate holidays at the Catalonian coast (Spain). No epidemiological connection between the two cases was found, and neither of them was treated with oseltamivir before specimen collection. Genetic analysis of the neuraminidase gene revealed the presence of previously described permissive mutations that may increase the likelihood of such strains emerging and spreading widely.
authors.affiliation: Laboratory for Infectious Diseases and Screening, National Institute for Public Health and the Environment (RIVM), Bilthoven, The Netherlands. adam.meijer@rivm.nl
authors.forename: A
authors.initials: A
authors.lastname: Meijer
authors.forename: M
authors.initials: M
authors.lastname: Jonges
authors.forename: P
authors.initials: P
authors.lastname: van Beek
authors.forename: C M
authors.initials: CM
authors.lastname: Swaan
authors.forename: A D
authors.initials: AD
authors.lastname: Osterhaus
authors.forename: R S
authors.initials: RS
authors.lastname: Daniels
authors.forename: A C
authors.initials: AC
authors.lastname: Hurt
authors.forename: M P
authors.initials: MP
authors.lastname: Koopmans
mesh_terms: D000293:Adolescent; D000998:Antiviral Agents / Q000494:pharmacology*; D024882:Drug Resistance, Viral / Q000235:genetics; D006801:Humans; D053118:Influenza A Virus, H1N1 Subtype / Q000187:drug effects* / Q000235:genetics / Q000302:isolation & purification; D007251:Influenza, Human / Q000175:diagnosis / Q000188:drug therapy / Q000821:virology*; D008969:Molecular Sequence Data; D009154:Mutation; D009426:Netherlands; D009439:Neuraminidase / Q000235:genetics; D053139:Oseltamivir / Q000494:pharmacology*; D018571:Sentinel Surveillance; D013030:Spain; D014195:Travel; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D000998:Antiviral Agents; D053139:Oseltamivir; D009439:Neuraminidase