title: Perioperative values of glutathione peroxidase activity and malondialdehyde levels in enolic cirrhotic recipients of a liver transplant.
abstract: Reactive oxygen species play a central role in ischemia-reperfusion injury after organ transplantation. They are degraded by endogenous radical scavengers such as antioxidant enzymes. The purpose of this study was to evaluate the temporal variation in glutathione peroxidase (GPX) activity and malondialdehyde (MDA) levels among alcoholic cirrhotic recipients of liver transplantations. The study included 30 recipients: 26 males and 4 females in the provided blood samples before and after transplantation. The results showed significant enhancement of MDA levels at 1 and 6 hours after transplantation: 4.458 ± 2.273 μmol/L and 4.4628 ± 2.405 μmol/L respectively (P < .001). In contrast, GPX activity showed a maximum at 3 days there after 3.541 ± 2,315 nmol/mg protein. In conclusion, although MDA levels show an enormous increase at 1 hour after transplantation suggesting lipid peroxidation, they were compensated by GPX activity thereafter, indicating control of the oxidative stress generated by liver transplantation.
authors.affiliation: General and Digestive Surgery Service, Virgen de las Nieves University Hospital, Granada, Spain.
authors.forename: K
authors.initials: K
authors.lastname: Muffak-Granero
authors.forename: C
authors.initials: C
authors.lastname: Olmedo
authors.forename: T
authors.initials: T
authors.lastname: Villegas
authors.forename: A
authors.initials: A
authors.lastname: Comino
authors.forename: A
authors.initials: A
authors.lastname: Becerra
authors.forename: J M
authors.initials: JM
authors.lastname: Villar
authors.forename: Y
authors.initials: Y
authors.lastname: Fundora
authors.forename: D
authors.initials: D
authors.lastname: Garrote
authors.forename: P
authors.initials: P
authors.lastname: Bueno
authors.forename: J-A
authors.initials: JA
authors.lastname: Ferrón
mesh_terms: D005260:Female; D005979:Glutathione Peroxidase / Q000097:blood*; D006801:Humans; D008104:Liver Cirrhosis, Alcoholic / Q000601:surgery*; D016031:Liver Transplantation; D008297:Male; D008315:Malondialdehyde / Q000097:blood*; D008875:Middle Aged; D018384:Oxidative Stress
chemical_list: D008315:Malondialdehyde; D005979:Glutathione Peroxidase