title: Antimicrobial treatment and containment measures for an extremely drug-resistant Klebsiella pneumoniae ST101 isolate carrying pKPN101-IT, a novel fully sequenced bla(KPC-2) plasmid.
abstract: An extremely drug-resistant Klebsiella pneumoniae isolate, sequence type ST101, was isolated from a patient in Italy. We describe antibiotic treatment, measures to clear and contain the infection, and a complete sequence analysis of a novel large plasmid, pKPN101-IT, harboring the bla(KPC-2) gene and arising from the threatening recombination of different worldwide-distributed backbones.
authors.affiliation: Department of Molecular Medicine, Padua, Italy.
authors.forename: Ilaria
authors.initials: I
authors.lastname: Frasson
authors.forename: Enrico
authors.initials: E
authors.lastname: Lavezzo
authors.forename: Elisa
authors.initials: E
authors.lastname: Franchin
authors.forename: Stefano
authors.initials: S
authors.lastname: Toppo
authors.forename: Luisa
authors.initials: L
authors.lastname: Barzon
authors.forename: Antonietta
authors.initials: A
authors.lastname: Cavallaro
authors.forename: Sara N
authors.initials: SN
authors.lastname: Richter
authors.forename: Giorgio
authors.initials: G
authors.lastname: Palù
mesh_terms: D000900:Anti-Bacterial Agents / Q000008:administration & dosage* / Q000494:pharmacology; D004269:DNA, Bacterial / Q000737:chemistry / Q000235:genetics; D024901:Drug Resistance, Multiple, Bacterial; D006801:Humans; D017053:Infection Control / Q000379:methods*; D007558:Italy; D007710:Klebsiella Infections / Q000188:drug therapy* / Q000382:microbiology*; D007711:Klebsiella pneumoniae / Q000187:drug effects* / Q000201:enzymology / Q000235:genetics / Q000302:isolation & purification; D008297:Male; D008875:Middle Aged; D008969:Molecular Sequence Data; D010957:Plasmids; D017422:Sequence Analysis, DNA; D001618:beta-Lactamases / Q000235:genetics / Q000378:metabolism*
chemical_list: D000900:Anti-Bacterial Agents; D004269:DNA, Bacterial; D001618:beta-Lactamases; C547585:beta-lactamase KPC-2, Klebsiella pneumoniae