title: Prognostic value of ultra-sensitive pregnancy associated plasma protein-A in patients with acute coronary syndrome.
abstract: OBJECTIVE
  To investigate the prognostic value of ultra-sensitive pregnancy associated plasma protein-A (PAPP-A) level in the early phase of acute coronary syndrome (ACS) attack.
  
  
  METHODS
  Patients diagnosed as ACS were enrolled and the level of circulatory PAPP-A was measured within 12 hours after ACS attack. The patients were followed at the time of 1st, 6th, and 12th months post-ACS attack in order to observe the incidence of the cardiovascular adverse events. According to the highest quintile, the patients were divided into 2 groups: high level (≥26.08 μg/L) group and low level (<26.08 μg/L) group, to evaluate the association between the level of PAPP-A and the incidence of the cardiovascular events.
  
  
  RESULTS
  Compared with the low level group, the incidence of the composite outcome is significantly increased in the high level group, and the values of OR are 4.76, 4.38, 3.75 for 1st, 6th, 12th months respectively (P=0.000). For myocardial infarction (MI) + cardiac death (CD) the values of OR were 9.81, 6.08, 4.12 (P<0.01). Multivariate logistic regression analysis demonstrates that PAPP-A was an independent risk factor for the cardiovascular adverse events in the early, median, and late phase of ACS (P<0.05).
  
  
  CONCLUSIONS
  In the early phase of ACS attack, the elevation of PAPP-A is an independent risk factor for the occurrence of cardiovascular adverse events.
authors.affiliation: Chinese PLA General Hospital, Beijing, China.
authors.forename: Yu-fa
authors.initials: YF
authors.lastname: Sun
authors.forename: Zhi-yong
authors.initials: ZY
authors.lastname: Yi
authors.forename: Zhi-xin
authors.initials: ZX
authors.lastname: Jiang
authors.forename: Li
authors.initials: L
authors.lastname: Fan
authors.forename: Xiao-ying
authors.initials: XY
authors.lastname: Li
authors.forename: Mei-qin
authors.initials: MQ
authors.lastname: Li
authors.forename: Bo
authors.initials: B
authors.lastname: Zhang
authors.forename: Zheng
authors.initials: Z
authors.lastname: Cha
authors.forename: Ya-wei
authors.initials: YW
authors.lastname: Liu
authors.forename: Feng-yi
authors.initials: FY
authors.lastname: Yuan
authors.forename: Jian
authors.initials: J
authors.lastname: Cao
mesh_terms: D054058:Acute Coronary Syndrome / Q000097:blood* / Q000175:diagnosis*; D000368:Aged; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011266:Pregnancy-Associated Plasma Protein-A / Q000378:metabolism*; D011379:Prognosis; D012307:Risk Factors
chemical_list: D011266:Pregnancy-Associated Plasma Protein-A