title: Bioinformatic analysis of data generated from MALDI mass spectrometry for biomarker discovery.
abstract: In this chapter we first describe the applications of matrix-assisted laser desorption/ionization (MALDI) mass spectrometry (MS) in biomarker discovery. After a summary of the general analysis pipeline of MALDI MS data, each step of the pipeline will be elaborated in detail. In particular we try to provide a categorization of existing solutions with the hope that the reader can obtain a global picture on this topic. In addition we show how to apply such an analysis pipeline in protein and glycan profiling for biomarker discovery and for a deeper understanding of diseases. Finally we discuss the limitations of current analysis methods and the perspectives of future research.
authors.affiliation: School of Software, Dalian University of Technology, Dalian, China. zyhe@dlut.edu.cn
authors.forename: Zengyou
authors.initials: Z
authors.lastname: He
authors.forename: Robert Z
authors.initials: RZ
authors.lastname: Qi
authors.forename: Weichuan
authors.initials: W
authors.lastname: Yu
mesh_terms: D000818:Animals; D015415:Biomarkers / Q000032:analysis; D019295:Computational Biology / Q000379:methods*; D057225:Data Mining / Q000379:methods; D006801:Humans; D010455:Peptides / Q000032:analysis; D011134:Polysaccharides / Q000032:analysis; D011506:Proteins / Q000032:analysis; D019032:Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization / Q000379:methods*
chemical_list: D015415:Biomarkers; D010455:Peptides; D011134:Polysaccharides; D011506:Proteins