title: Effect of subthalamic deep brain stimulation on pain in Parkinson's disease.
abstract: Painful sensations are common in Parkinson's disease. In many patients, such sensations correspond to neuropathic pain and could be related to central alterations of pain processing. Subthalamic nuclei deep brain stimulation improves motor function in Parkinson's disease. Several structures of the basal ganglia are involved in nociceptive function, and deep brain stimulation could thus also modify pain perception in Parkinson's disease. To test this hypothesis, we compared subjective heat pain thresholds, in deep brain stimulation OFF and ON conditions in 2 groups of Parkinson's disease patients with or without neuropathic pain. We also compared pain-induced cerebral activations during experimental nociceptive stimulations using H(2)(15)O positron emission tomography in both deep brain stimulation OFF and ON conditions. Correlation analyses were performed between clinical and neuroimaging results. Deep brain stimulation significantly increased subjective heat pain threshold (from 40.3 ± 4.2 to 41.6 ± 4.3, P=.03) and reduced pain-induced cerebral activity in the somatosensory cortex (BA 40) in patients with pain, whereas it had no effect in pain-free patients. There was a significant negative correlation in the deep brain stimulation OFF condition between pain threshold and pain-induced activity in the insula of patients who were pain free but not in those who had pain. There was a significant positive correlation between deep brain stimulation-induced changes in pain threshold and in pain-induced cerebral activations in the primary somatosensory cortex and insula of painful patients only. These results suggest that subthalamic nuclei deep brain stimulation raised pain thresholds in Parkinson's disease patients with pain and restored better functioning of the lateral discriminative pain system.
authors.affiliation: INSERM, Imagerie cérébrale et handicaps neurologiques, Toulouse, France Université de Toulouse, Imagerie cérébrale et handicaps neurologiques, Toulouse, France Department of Neurology, University Hospital of Toulouse, Toulouse, France INSERM, Clinical Investigation Center, Purpan, Toulouse, France Department of Neurosurgery, University Hospital of Toulouse, Toulouse, France Department of Clinical Pharmacology, University of Medicine, Toulouse, France.
authors.forename: Estelle
authors.initials: E
authors.lastname: Dellapina
authors.forename: Fabienne
authors.initials: F
authors.lastname: Ory-Magne
authors.forename: Wafa
authors.initials: W
authors.lastname: Regragui
authors.forename: Claire
authors.initials: C
authors.lastname: Thalamas
authors.forename: Yves
authors.initials: Y
authors.lastname: Lazorthes
authors.forename: Olivier
authors.initials: O
authors.lastname: Rascol
authors.forename: Pierre
authors.initials: P
authors.lastname: Payoux
authors.forename: Christine
authors.initials: C
authors.lastname: Brefel-Courbon
mesh_terms: D000368:Aged; D015331:Cohort Studies; D018592:Cross-Over Studies; D046690:Deep Brain Stimulation / Q000379:methods*; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009437:Neuralgia / Q000000981:diagnostic imaging / Q000209:etiology / Q000628:therapy*; D010147:Pain Measurement / Q000379:methods; D010300:Parkinson Disease / Q000150:complications / Q000000981:diagnostic imaging / Q000628:therapy*; D011877:Radionuclide Imaging; D020531:Subthalamic Nucleus / Q000000981:diagnostic imaging / Q000502:physiology*