title: Synthesis, antimicrobial and cytotoxicity study of 1,3-disubstituted-1H-naphtho[1,2-e][1,3]oxazines.
abstract: A series of new 1,3-disubstituted-1H-naphtho[1,2-e][1,3]oxazines (3 and 7) was synthesized in good yields and the structure was determined with the help of NMR, 2D-NMR, HRMS studies and X-ray crystallography. These compounds were tested in vitro for their antibacterial activity against Gram-positive and Gram-negative bacteria and as well as for antifungal activity. The compounds 3c, 3e, 7a, 7d and 7k showed significant antibacterial activity and 7l showed moderate antifungal activity. The cytotoxicity of 1,3-disubstituted-1H-naphtho[1,2-e][1,3]oxazines showed that 3e and 7e are more effective against breast, lung and colon cell proliferation.
authors.affiliation: Department of Chemistry, Guru Jambheshwar University of Science & Technology, Hisar 125001, Haryana, India.
authors.forename: Vikas
authors.initials: V
authors.lastname: Verma
authors.forename: Kuldeep
authors.initials: K
authors.lastname: Singh
authors.forename: Devinder
authors.initials: D
authors.lastname: Kumar
authors.forename: Thomas M
authors.initials: TM
authors.lastname: Klapötke
authors.forename: Jörg
authors.initials: J
authors.lastname: Stierstorfer
authors.forename: Balasubramanian
authors.initials: B
authors.lastname: Narasimhan
authors.forename: Asif Khurshid
authors.initials: AK
authors.lastname: Qazi
authors.forename: Abid
authors.initials: A
authors.lastname: Hamid
authors.forename: Sundeep
authors.initials: S
authors.lastname: Jaglan
mesh_terms: D000900:Anti-Bacterial Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D000935:Antifungal Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D001234:Aspergillus niger / Q000187:drug effects*; D002176:Candida albicans / Q000187:drug effects*; D049109:Cell Proliferation / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D004354:Drug Screening Assays, Antitumor; D006090:Gram-Negative Bacteria / Q000187:drug effects*; D006094:Gram-Positive Bacteria / Q000187:drug effects*; D006801:Humans; D008826:Microbial Sensitivity Tests; D008958:Models, Molecular; D015394:Molecular Structure; D013329:Structure-Activity Relationship; D014407:Tumor Cells, Cultured
chemical_list: D000900:Anti-Bacterial Agents; D000935:Antifungal Agents