title: Hemodynamic effects of furosemide on renal perfusion as evaluated by ASL-MRI.
abstract: OBJECTIVE
  The aim of this study was to investigate the short-term effects of furosemide on renal perfusion by using arterial spin labeling (ASL) magnetic resonance imaging.
  
  
  METHODS
  Eleven healthy human subjects were enrolled in the study. The measurement of renal blood flow (RBF) was performed by applying an ASL technique with flow-sensitive alternating inversion recovery spin preparation and a single-shot fast spin-echo imaging strategy on a 3.0-T magnetic resonance scanner. For all subjects, the ASL magnetic resonance images were obtained before agent injection as a baseline scan. Then 20 mg of furosemide was injected intravenously. Postfurosemide ASL images were acquired following administration to evaluate the renal hemodynamic response.
  
  
  RESULTS
  Postinjection scans showed that cortical RBF decreased from 366.59 ± 41.19 mL/100 g/min at baseline to 314.33 ± 48.83 mL/100 g/min at 10 minutes after the administration of furosemide (paired t test, P = .04 vs baseline), and medullary RBF decreased from 118.59 ± 24.69 mL/100 g/min at baseline to 97.38 ± 18.40 mL/100 g/min at 10 minutes after the administration of furosemide (paired t test, P = .01 vs baseline). There was a negative correlation between the furosemide-induced diuretic effect and the reduction of RBF (Spearman's r = -0.61).
  
  
  CONCLUSIONS
  The dominant hemodynamic effect of furosemide on the kidney is associated with a decrease in both cortical and medullary blood perfusion. Furthermore, the quantitative ASL technique may provide an alternative way to noninvasively monitor the change in renal function due to furosemide administration.
authors.affiliation: Academy for Advanced Interdisciplinary Studies, Peking University, Yiheyuan Road No 5, Beijing 100871, China.
authors.forename: Jing
authors.initials: J
authors.lastname: Wang
authors.forename: Yudong
authors.initials: Y
authors.lastname: Zhang
authors.forename: Xuedong
authors.initials: X
authors.lastname: Yang
authors.forename: Xiaoying
authors.initials: X
authors.lastname: Wang
authors.forename: Jue
authors.initials: J
authors.lastname: Zhang
authors.forename: Jing
authors.initials: J
authors.lastname: Fang
authors.forename: Xuexiang
authors.initials: X
authors.lastname: Jiang
mesh_terms: D000328:Adult; D001783:Blood Flow Velocity / Q000187:drug effects / Q000502:physiology; D004232:Diuretics / Q000008:administration & dosage; D005260:Female; D005665:Furosemide / Q000008:administration & dosage*; D006801:Humans; D018810:Magnetic Resonance Angiography / Q000379:methods*; D008297:Male; D012077:Renal Artery / Q000033:anatomy & histology* / Q000503:physiopathology*; D012079:Renal Circulation / Q000187:drug effects*; D013113:Spin Labels; D055815:Young Adult
chemical_list: D004232:Diuretics; D013113:Spin Labels; D005665:Furosemide