title: Resveratrol attenuates oxidative stress and prevents steatosis and hypertension in obese rats programmed by early weaning.
abstract: We hypothesized that resveratrol, a natural phytoalexin found in grapes, can prevent oxidative stress, obesity and its related disturbances in obese rats programmed by early weaning. Lactating Wistar rats were separated into two groups: early weaning (EW) - dams who were wrapped with a bandage to interrupt the lactation in the last 3 days of lactation; control - dams whose pups had free access to milk during all lactation. At the 150th day, EW offspring were randomly subdivided into EW+resveratrol (EW+Res) - resveratrol (30 mg/kg/day); EW+vehicle (EW) - rats that received 0.5% (w/v) aqueous methylcellulose. The control group received vehicle. Rats were treated by gavage daily for 30 days. EW offspring developed hyperphagia, higher body weight, visceral obesity, higher systolic (SBP) and diastolic blood pressure (DBP) (+15% and +20%, respectively; P<.05) and higher serum triglycerides (TG) and low-density lipoprotein but lower high-density lipoprotein (+55%, +33% and -13%, respectively; P<.05). Resveratrol normalized food intake, SBP and DBP and prevented obesity and dyslipidemia in EW+Res. EW rats had higher plasma and liver thiobarbituric-acid-reactive substances (TBARS) and lower plasma superoxide dismutase (SOD) and liver glutathione peroxidase activities (+51%, +18%, -58%, -31%, respectively; P<.05), and resveratrol normalized both plasma and liver TBARS and increased the activity of SOD and catalase in plasma. EW rats presented liver steatosis and higher liver TG, and resveratrol prevented these hepatic alterations. In conclusion, this study demonstrated a potential therapeutic use of resveratrol in preventing obesity and oxidative stress and reducing the risk of hypertension, dyslipidemia and steatosis in adult rats programmed by early weaning.
authors.affiliation: Department of Physiological Sciences, Roberto Alcantara Gomes Biology Institute, State University of Rio de Janeiro, Rio de Janeiro, RJ, 20550-030, Brazil.
authors.forename: Juliana G
authors.initials: JG
authors.lastname: Franco
authors.forename: Patrícia C
authors.initials: PC
authors.lastname: Lisboa
authors.forename: Natália S
authors.initials: NS
authors.lastname: Lima
authors.forename: Taline A S
authors.initials: TA
authors.lastname: Amaral
authors.forename: Nayara
authors.initials: N
authors.lastname: Peixoto-Silva
authors.forename: Angela C
authors.initials: AC
authors.lastname: Resende
authors.forename: Elaine
authors.initials: E
authors.lastname: Oliveira
authors.forename: Magna C F
authors.initials: MC
authors.lastname: Passos
authors.forename: Egberto G
authors.initials: EG
authors.lastname: Moura
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000494:pharmacology* / Q000627:therapeutic use; D001786:Blood Glucose / Q000378:metabolism; D050171:Dyslipidemias / Q000209:etiology / Q000517:prevention & control; D005234:Fatty Liver / Q000209:etiology / Q000378:metabolism / Q000517:prevention & control*; D005260:Female; D005979:Glutathione Peroxidase / Q000378:metabolism; D006963:Hyperphagia / Q000209:etiology / Q000378:metabolism / Q000517:prevention & control; D006973:Hypertension / Q000209:etiology / Q000378:metabolism / Q000517:prevention & control*; D007333:Insulin Resistance; D008099:Liver / Q000378:metabolism / Q000473:pathology; D009765:Obesity / Q000150:complications / Q000378:metabolism*; D018384:Oxidative Stress; D051381:Rats; D017208:Rats, Wistar; D000077185:Resveratrol; D013267:Stilbenes / Q000494:pharmacology* / Q000627:therapeutic use; D013482:Superoxide Dismutase / Q000097:blood; D017392:Thiobarbituric Acid Reactive Substances / Q000378:metabolism; D014886:Weaning
chemical_list: D000975:Antioxidants; D001786:Blood Glucose; D013267:Stilbenes; D017392:Thiobarbituric Acid Reactive Substances; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase; D000077185:Resveratrol