title: Antiviral properties against HIV of water soluble copper carbosilane dendrimers and their EPR characterization.
abstract: We describe here the use of anionic carbosilane dendrimers to obtain new copper complexes. UV-Vis and a computer aided analysis of the EPR spectra provided information about the coordination modes of copper depending on the nature of the dendrimer and about the geometry and structure of the complexes in solution. Some of these metallo-dendrimers have been tested "in vitro" as antiviral compounds in the inhibition of HIV infection in pre and post-infection treatment.
authors.affiliation: Departamento de Quimica Inorganica, Universidad de Alcala, Campus Universitario. Edificio de Farmacia, 28871 Alcala de Henares, Spain.
authors.forename: M
authors.initials: M
authors.lastname: Galan
authors.forename: J
authors.initials: J
authors.lastname: Sanchez-Rodriguez
authors.forename: M
authors.initials: M
authors.lastname: Cangiotti
authors.forename: S
authors.initials: S
authors.lastname: Garcia-Gallego
authors.forename: J L
authors.initials: JL
authors.lastname: Jimenez
authors.forename: R
authors.initials: R
authors.lastname: Gomez
authors.forename: M F
authors.initials: MF
authors.lastname: Ottaviani
authors.forename: M A
authors.initials: MA
authors.lastname: Munoz-Fernandez
authors.forename: F J
authors.initials: FJ
authors.lastname: de la Mata
mesh_terms: D019380:Anti-HIV Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D045744:Cell Line, Tumor; D056831:Coordination Complexes / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D003300:Copper / Q000737:chemistry* / Q000494:pharmacology; D050091:Dendrimers / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D004578:Electron Spin Resonance Spectroscopy; D004847:Epithelial Cells / Q000821:virology; D005260:Female; D015658:HIV Infections / Q000517:prevention & control / Q000821:virology; D015497:HIV-1 / Q000502:physiology; D006801:Humans; D012821:Silanes / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D013056:Spectrophotometry, Ultraviolet; D014621:Vagina / Q000821:virology; D053586:Virus Internalization / Q000187:drug effects
chemical_list: D019380:Anti-HIV Agents; D056831:Coordination Complexes; D050091:Dendrimers; D012821:Silanes; C504072:carbosilane; D003300:Copper