title: Treatment of chest wall osteosarcoma presenting as second primary after treatment of neuroblastoma.
abstract: Only 2 cases of osteosarcoma as a second primary malignancy after neuroblastoma have been reported in the literature. We present a case of chest wall osteosarcoma that developed in a 14-year-old boy 7 years after completion of chemotherapy, autologous peripheral blood stem cell transplantation, radiation, and resection for stage 3, high-risk neuroblastoma. A biopsy of a painful chest wall mass arising from the right third rib diagnosed osteosarcoma. He went on to have preoperative chemotherapy followed by wide local excision and chest wall reconstruction. He then received additional chemotherapy. This case highlights the importance of close observation for second malignancies in this patient population.
authors.affiliation: Department of Pediatric Surgery, Children's Mercy Hospitals and Clinics, Kansas City, MO 64108, USA. mknott@cmh.edu
authors.forename: E Marty
authors.initials: EM
authors.lastname: Knott
authors.forename: Sohail R
authors.initials: SR
authors.lastname: Shah
authors.forename: Gary
authors.initials: G
authors.lastname: Jones
authors.forename: Maxine
authors.initials: M
authors.lastname: Hetherington
authors.forename: Ronald J
authors.initials: RJ
authors.lastname: Sharp
mesh_terms: D000293:Adolescent; D000970:Antineoplastic Agents / Q000627:therapeutic use; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D001859:Bone Neoplasms / Q000175:diagnosis / Q000188:drug therapy / Q000601:surgery*; D017024:Chemotherapy, Adjuvant; D002648:Child; D003131:Combined Modality Therapy; D006801:Humans; D008297:Male; D016609:Neoplasms, Second Primary / Q000175:diagnosis / Q000188:drug therapy / Q000601:surgery*; D009447:Neuroblastoma / Q000628:therapy*; D012516:Osteosarcoma / Q000175:diagnosis / Q000188:drug therapy / Q000601:surgery*; D019651:Plastic Surgery Procedures; D012186:Retroperitoneal Neoplasms / Q000628:therapy*; D012272:Ribs / Q000473:pathology / Q000601:surgery
chemical_list: D000970:Antineoplastic Agents