title: The 50 Hz (10 mT) sinusoidal magnetic field: effects on stress-related behavior of rats.
abstract: OBJECTIVE
  The purpose of this study was to investigate the behavioral changes induced by 50 Hz, 10 mT flux density Sinusoidal Magnetic Field (MF).
  
  
  METHODS
  Seventy-six young adult male Wistar albino rats were used in the study. They were separated into two groups: control group (C) n=38; MF group n=38. C animals were left under the same conditions with the MF group for 21 days but with prevented or avoided exposure to MF. Anxiety and stress-related behavioral changes were investigated by elevated plus-maze and hole-board systems. Just before being tested in the maze, each animal was tested by means of the hole-board method in order to separate the directed exploration behavior and locomotion activity changes from anxiety-related behavior.
  
  
  RESULTS
  In the hole-board system parameters there were no statistically significant differences between the two groups. There was a statistically significant difference between MF and C groups when the ratio of time spent on open arms to the total time spent on all arms was evaluated (0.12±0.08 and 0.34±0.18 respectively and p <0.01).
  
  
  CONCLUSIONS
  Our results suggest that after 21 days, a continuous exposure to extremely low frequency of magnetic field (50 Hz, 10 mT) has no significant effect on activity and exploration activity but significantly induces stress and anxiety-related behavior in rats (Tab. 2, Fig. 9, Ref. 19).
authors.affiliation: Department of Biophysics, Istanbul University, Istanbul, Turkey.
authors.forename: M A
authors.initials: MA
authors.lastname: Korpinar
authors.forename: M T
authors.initials: MT
authors.lastname: Kalkan
authors.forename: H
authors.initials: H
authors.lastname: Tuncel
mesh_terms: D000818:Animals; D001007:Anxiety; D001522:Behavior, Animal; D004574:Electromagnetic Fields; D008297:Male; D018782:Maze Learning; D051381:Rats; D017208:Rats, Wistar