title: [Risk pregnancies and how to treat them].
abstract: Recurrent abortions are a common problem. A therapy with low-molecular- weight heparin is usual in deep vein thrombosis with thrombophilia, in woman with recurrent abortions or other risks, like EPH-gestosis or HELLP-Syndrom.
  
  
  METHODS
  The efficacy of a mono-therapy with LMWH (3000-16000 daily) in women with risk pregnancies has been examined prospectively. The dates of 676 pregnant women have been analysed and compared to the current literature about live birth rates without therapy and tot he results of other, similar studies. The live birth rate has been the target variable.
  
  
  RESULTS
  We obtained main a live birth rate of 98.6%. There has been no record of serious adverse effects. We obtained a live birth rate of 95.8% if NMH therapy starts early, and a live birth rate of 100% if NMH therapy starts between week 20 and 25. For the live birth rate the existence of thrombophilic gene polymorphisms is irrelevant.
  
  
  CONCLUSIONS
  The high live birth weight is depended on early starting the therapy with NMH. For the late risk it is favourable to start the therapy with heparin between week 20 and 25 week of pregnancy.
authors.affiliation: Haemostaseologicum MVZ GbR Berlin, Berlin. kiesewetter@haemostaseologicum.com
authors.forename: H
authors.initials: H
authors.lastname: Kiesewetter
authors.forename: H
authors.initials: H
authors.lastname: Radtke
authors.forename: R
authors.initials: R
authors.lastname: Becker
authors.forename: F-P
authors.initials: FP
authors.lastname: Schmidt
authors.forename: K
authors.initials: K
authors.lastname: Körber
authors.forename: N
authors.initials: N
authors.lastname: Vehlow
mesh_terms: D000026:Abortion, Habitual / Q000453:epidemiology* / Q000517:prevention & control*; D000293:Adolescent; D000328:Adult; D000925:Anticoagulants / Q000627:therapeutic use; D001778:Blood Coagulation Disorders / Q000453:epidemiology* / Q000517:prevention & control*; D015897:Comorbidity; D005260:Female; D005858:Germany / Q000453:epidemiology; D006495:Heparin, Low-Molecular-Weight / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D011247:Pregnancy; D011248:Pregnancy Complications / Q000453:epidemiology* / Q000517:prevention & control*; D015995:Prevalence; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D000925:Anticoagulants; D006495:Heparin, Low-Molecular-Weight