title: Two new p-terphenyl derivatives from the marine fungal strain Aspergillus sp. AF119.
abstract: Two new p-terphenyl derivatives (1, 2), together with six known ones (3-8), have been isolated from the marine fungal strain Aspergillus sp. AF119. The structures for terphyl acid (1) and terphyl diacid (2) were determined on the basis of HR Q-TOF-MS, and 1D- and 2D-NMR spectroscopic data. The in vitro cytotoxic activities of compounds 1-8 were tested against human tumor cell lines HeLa, HepG-2 and MDA-MB-435; only compounds 5-8 exhibited inhibitory activity against the tested cell lines with IC50 values < 20 microM. Moreover, compound 5 showed a mechanism of inducing cell cycle arrest and apoptosis mediated by the generation of ROS and subsequent DNA double-strand break.
authors.affiliation: School of Life Sciences, Xiamen University, Fujian 361005, PR China.
authors.forename: Shao-Song
authors.initials: SS
authors.lastname: Liu
authors.forename: Bao-Bing
authors.initials: BB
authors.lastname: Zhao
authors.forename: Chun-Hua
authors.initials: CH
authors.lastname: Lu
authors.forename: Jing-Jing
authors.initials: JJ
authors.lastname: Huang
authors.forename: Yue-Mao
authors.initials: YM
authors.lastname: Shen
mesh_terms: D000935:Antifungal Agents / Q000737:chemistry* / Q000494:pharmacology*; D001230:Aspergillus / Q000737:chemistry*; D015394:Molecular Structure; D013730:Terphenyl Compounds / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D000935:Antifungal Agents; D013730:Terphenyl Compounds