title: Association of cytotoxic T-lymphocyte associated antigen 4 gene polymorphism with type 1 diabetes mellitus: a meta-analysis.
abstract: To evaluate the association between costimulatory molecule cytotoxic T-lymphocyte-associated antigen-4 (CTLA-4) gene polymorphism and type 1 diabetes mellitus(T1DM), sixty-three published studies before December, 2011 were included. Meta-analysis was performed for each genotype in a random/fixed effect model. The combined odds ratio (OR) with 95% confidence interval (95%CI) was calculated to estimate the strength of the association. Overall, significant correlation was noted between CTLA-4 gene polymorphism (i.e. +49A/G, CT60A/G in a per-allele model) and the risk of T1DM (for +49A/G: OR=1.47, 95%CI=1.36-1.60, P<0.001; for CT60A/G: OR=1.31, 95%CI=1.18-1.45, P<0.001). However, no significant association was noted between C(-318)T polymorphism and T1DM. In the subgroup analysis, for +49A/G and CT60A/G, the statistically significant associations were also demonstrated in diverse racial descents (Caucasian and Asian) and age of onset (<20 years and >20 years). In conclusion, our results suggest that CTLA-4 polymorphism contributes to the susceptibility of T1DM.
authors.affiliation: Department of Endocrinology, The First Affiliated Hospital of Anhui Medical University, 218 Jixi Road, Hefei230022, China.
authors.forename: Song-tao
authors.initials: ST
authors.lastname: Tang
authors.forename: Hai-qin
authors.initials: HQ
authors.lastname: Tang
authors.forename: Qiu
authors.initials: Q
authors.lastname: Zhang
authors.forename: Chang-jiang
authors.initials: CJ
authors.lastname: Wang
authors.forename: You-min
authors.initials: YM
authors.lastname: Wang
authors.forename: Wen-jia
authors.initials: WJ
authors.lastname: Peng
mesh_terms: D060908:CTLA-4 Antigen / Q000235:genetics*; D003922:Diabetes Mellitus, Type 1 / Q000235:genetics*; D005838:Genotype; D006801:Humans; D011110:Polymorphism, Genetic / Q000235:genetics*
chemical_list: D060908:CTLA-4 Antigen; C556706:CTLA4 protein, human