title: Potential blood biomarkers for stroke.
abstract: Stroke is one of the most common causes of death worldwide and a major cause of acquired disability in adults. Despite advances in research during the last decade, prevention and treatment strategies still suffer from significant limitations, and therefore new theoretical and technical approaches are required. Technological advances in the proteomic and metabolomic areas, during recent years, have permitted a more effective search for novel biomarkers and therapeutic targets that may allow for effective risk stratification and early diagnosis with subsequent rapid treatment. This review provides a comprehensive overview of the latest candidate proteins and metabolites proposed as new potential biomarkers in stroke.
authors.affiliation: Laboratory of Vascular Pathophysiology, Hospital Nacional de Paraplejicos, SESCAM, Toledo, Spain.
authors.forename: Carlos M
authors.initials: CM
authors.lastname: Laborde
authors.forename: Laura
authors.initials: L
authors.lastname: Mourino-Alvarez
authors.forename: Finn
authors.initials: F
authors.lastname: Akerstrom
authors.forename: Luis R
authors.initials: LR
authors.lastname: Padial
authors.forename: Fernando
authors.initials: F
authors.lastname: Vivanco
authors.forename: Felix
authors.initials: F
authors.lastname: Gil-Dones
authors.forename: Maria G
authors.initials: MG
authors.lastname: Barderas
mesh_terms: D015415:Biomarkers / Q000097:blood*; D001798:Blood Proteins / Q000032:analysis*; D001921:Brain / Q000378:metabolism / Q000473:pathology; D006801:Humans; D013058:Mass Spectrometry / Q000379:methods; D055442:Metabolome; D055432:Metabolomics / Q000379:methods / Q000592:standards; D011379:Prognosis; D020543:Proteome / Q000032:analysis*; D040901:Proteomics / Q000379:methods / Q000592:standards; D012372:ROC Curve; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D020521:Stroke / Q000145:classification / Q000175:diagnosis* / Q000378:metabolism; D013917:Thrombin / Q000378:metabolism
chemical_list: D015415:Biomarkers; D001798:Blood Proteins; D020543:Proteome; D013917:Thrombin