title: In vitro antifungal activity of isavuconazole against Madurella mycetomatis.
abstract: Currently, therapy of black-grain mycetoma caused by Madurella mycetomatis consists of extensive debridement of the infected tissue combined with prolonged antifungal therapy with ketoconazole or itraconazole. In the present study, the in vitro activity of the new triazole isavuconazole toward M. mycetomatis was evaluated. Isavuconazole appeared to have high activity against M. mycetomatis, with MICs ranging from ≤0.016 to 0.125 μg/ml. Due to its favorable pharmacokinetics, isavuconazole could be a promising antifungal agent in the treatment of mycetoma.
authors.affiliation: Erasmus MC, University Medical Center Rotterdam, Department of Medical Microbiology and Infectious Diseases, Rotterdam, The Netherlands. w.kloezen@erasmusmc.nl
authors.forename: Wendy
authors.initials: W
authors.lastname: Kloezen
authors.forename: Jacques F
authors.initials: JF
authors.lastname: Meis
authors.forename: Ilse
authors.initials: I
authors.lastname: Curfs-Breuker
authors.forename: Ahmed H
authors.initials: AH
authors.lastname: Fahal
authors.forename: Wendy W J
authors.initials: WW
authors.lastname: van de Sande
mesh_terms: D000935:Antifungal Agents / Q000494:pharmacology*; D006801:Humans; D017964:Itraconazole / Q000494:pharmacology*; D007654:Ketoconazole / Q000494:pharmacology*; D020461:Madurella / Q000187:drug effects* / Q000254:growth & development / Q000302:isolation & purification; D008826:Microbial Sensitivity Tests; D008271:Mycetoma / Q000188:drug therapy / Q000382:microbiology; D009570:Nitriles / Q000494:pharmacology*; D011725:Pyridines / Q000494:pharmacology*; D014230:Triazoles / Q000494:pharmacology*
chemical_list: D000935:Antifungal Agents; D009570:Nitriles; D011725:Pyridines; D014230:Triazoles; D017964:Itraconazole; C508735:isavuconazole; D007654:Ketoconazole