title: Balancing selection on MHC class I in wild brown trout Salmo trutta.
abstract: Evidence is reported for balancing selection acting on variation at major histocompatibility complex (MHC) in wild populations of brown trout Salmo trutta. First, variation at an MHC class I (satr-uba)-linked microsatellite locus (mhc1) is retained in small S. trutta populations isolated above waterfalls although variation is lost at neutral microsatellite markers. Second, populations across several catchments are less differentiated at mhc1 than at neutral markers, as predicted by theory. The population structure of these fish was also elucidated.
authors.affiliation: Environmental Research Institute, University College Cork, Cork, Ireland. b.ofarrell@ucc.ie
authors.forename: B
authors.initials: B
authors.lastname: O'Farrell
authors.forename: C
authors.initials: C
authors.lastname: Dennis
authors.forename: J A
authors.initials: JA
authors.lastname: Benzie
authors.forename: P
authors.initials: P
authors.lastname: McGinnity
authors.forename: J
authors.initials: J
authors.lastname: Carlsson
authors.forename: E
authors.initials: E
authors.lastname: de Eyto
authors.forename: J P
authors.initials: JP
authors.lastname: Coughlan
authors.forename: F
authors.initials: F
authors.lastname: Igoe
authors.forename: R
authors.initials: R
authors.lastname: Meehan
authors.forename: T F
authors.initials: TF
authors.lastname: Cross
mesh_terms: D000818:Animals; D005805:Genes, MHC Class I / Q000235:genetics*; D014644:Genetic Variation; D005828:Genetics, Population; D018895:Microsatellite Repeats / Q000235:genetics; D012641:Selection, Genetic; D014337:Trout / Q000235:genetics*