title: The evolution of pigeon paramyxovirus type 1 (PPMV-1) in Great Britain: a molecular epidemiological study.
abstract: Newcastle disease (ND), caused by virulent strains of avian paramyxovirus type 1 (APMV-1), is considered throughout the world as one of the most important animal diseases. For over three decades now, there has been a continuing panzootic caused by a variant virulent APMV-1 strain, so-called pigeon paramyxovirus type 1 (PPMV-1), primarily in racing pigeons, which has also spread to wild birds and poultry. PPMV-1 isolations have been made in Great Britain every year since 1983. In this study, we have completed a comparative phylogenetic analysis based on a 374 nucleotide section of the fusion protein gene of 63 isolates of PPMV-1 that were isolated over a 26-year period; 43 of these were sequenced for this study. Phylogenetic analysis of these sequences revealed that all were closely related and placed in the genetic sublineage 4b (VIb), subdivision 4biif.
authors.affiliation: AHVLA-Weybridge, Surrey, UK.
authors.forename: E W
authors.initials: EW
authors.lastname: Aldous
authors.forename: C M
authors.initials: CM
authors.lastname: Fuller
authors.forename: J H
authors.initials: JH
authors.lastname: Ridgeon
authors.forename: R M
authors.initials: RM
authors.lastname: Irvine
authors.forename: D J
authors.initials: DJ
authors.lastname: Alexander
authors.forename: I H
authors.initials: IH
authors.lastname: Brown
mesh_terms: D000818:Animals; D010856:Columbidae / Q000821:virology*; D004196:Disease Outbreaks / Q000662:veterinary; D016021:Epidemiologic Studies; D017720:Molecular Epidemiology / Q000379:methods; D009521:Newcastle Disease / Q000453:epidemiology / Q000821:virology*; D009522:Newcastle disease virus / Q000235:genetics* / Q000302:isolation & purification; D010802:Phylogeny; D012367:RNA, Viral / Q000032:analysis*; D060888:Real-Time Polymerase Chain Reaction; D006113:United Kingdom / Q000453:epidemiology
chemical_list: D012367:RNA, Viral