title: Mood congruent psychotic symptoms and specific cognitive deficits in carriers of the novel schizophrenia risk variant at MIR-137.
abstract: OBJECTIVE
  The Schizophrenia Psychiatric Genome-wide Association (GWAS) Consortium recently reported on five novel schizophrenia susceptibility loci. The most significant finding mapped to a micro-RNA, MIR-137, which may be involved in regulating the function of other schizophrenia and bipolar disorder susceptibility genes.
  
  
  METHODS
  We genotyped 821 patients with confirmed DSM-IV diagnoses of schizophrenia, bipolar affective disorder I and schizoaffective disorder for the risk SNP (rs1625579) and investigated the clinical profiles of risk allele carriers using a within-case design. We also assessed neurocognitive performance in a subset of cases (n=399) and controls (n=171).
  
  
  RESULTS
  Carriers of the risk allele had lower scores for an OPCRIT-derived positive symptom factor (p=0.04) and lower scores on a lifetime measure of psychosis incongruity (p=0.017). Risk allele carriers also had more cognitive deficits involving episodic memory and attentional control.
  
  
  CONCLUSIONS
  This is the first evidence that the MIR-137 risk variant may be associated with a specific subgroup of psychosis patients. Although the effect of this single SNP was not clinically relevant, investigation of the impact of carrying multiple risk SNPs in the MIR-137 regulatory network on diagnosis and illness profile may be warranted.
authors.affiliation: Dept of Psychiatry & Neuropsychiatric Genetics Group, Institute of Molecular Medicine, Trinity College Dublin, Dublin 2, Ireland.
authors.forename: E
authors.initials: E
authors.lastname: Cummings
authors.forename: G
authors.initials: G
authors.lastname: Donohoe
authors.forename: A
authors.initials: A
authors.lastname: Hargreaves
authors.forename: S
authors.initials: S
authors.lastname: Moore
authors.forename: C
authors.initials: C
authors.lastname: Fahey
authors.forename: T G
authors.initials: TG
authors.lastname: Dinan
authors.forename: C
authors.initials: C
authors.lastname: McDonald
authors.forename: E
authors.initials: E
authors.lastname: O'Callaghan
authors.forename: F A
authors.initials: FA
authors.lastname: O'Neill
authors.forename: J L
authors.initials: JL
authors.lastname: Waddington
authors.forename: K C
authors.initials: KC
authors.lastname: Murphy
authors.forename: D W
authors.initials: DW
authors.lastname: Morris
authors.forename: M
authors.initials: M
authors.lastname: Gill
authors.forename: A
authors.initials: A
authors.lastname: Corvin
mesh_terms: D000293:Adolescent; D000328:Adult; D001714:Bipolar Disorder / Q000235:genetics; D016022:Case-Control Studies; D003072:Cognition Disorders / Q000235:genetics*; D056726:Genetic Association Studies; D005838:Genotype; D006579:Heterozygote; D006801:Humans; D035683:MicroRNAs / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D011618:Psychotic Disorders / Q000235:genetics; D012559:Schizophrenia / Q000235:genetics*; D012565:Schizophrenic Psychology; D055815:Young Adult
chemical_list: C545567:MIRN137 microRNA, human; D035683:MicroRNAs