title: The antimicrobial and osteoinductive properties of silver nanoparticle/poly (DL-lactic-co-glycolic acid)-coated stainless steel.
abstract: Implant-associated bacterial infections are one of the most serious complications in orthopedic surgery. Treatment of these infections often requires multiple operations, device removal, long-term systemic antibiotics, and extended rehabilitation, and is frequently ineffective, leading to worse clinical outcomes and increased financial costs. In this study, we evaluated silver nanoparticle/poly(DL-lactic-co-glycolic acid) (PLGA)-coated stainless steel alloy(SNPSA) as a potential antimicrobial implant material. We found that SNPSA exhibited strong antibacterial activity in vitro and ex vivo, and promoted MC3T3-E1 pre-osteoblasts proliferation and maturation in vitro. Furthermore, SNPSA implants induced osteogenesis while suppressing bacterial survival in contaminated rat femoral canals. Our results indicate that SNPSA has simultaneous antimicrobial and osteoinductive properties that make it a promising therapeutic material in orthopedic surgery.
authors.affiliation: Shandong Provincial Laboratory of Oral Biomedicine, School and Hospital of Stomatology, Shandong University, Jinan, Shandong 250012, PR China.
authors.forename: Yi
authors.initials: Y
authors.lastname: Liu
authors.forename: Zhong
authors.initials: Z
authors.lastname: Zheng
authors.forename: Janette N
authors.initials: JN
authors.lastname: Zara
authors.forename: Chingyun
authors.initials: C
authors.lastname: Hsu
authors.forename: Donnalisa E
authors.initials: DE
authors.lastname: Soofer
authors.forename: Kevin S
authors.initials: KS
authors.lastname: Lee
authors.forename: Ronald K
authors.initials: RK
authors.lastname: Siu
authors.forename: Lloyd S
authors.initials: LS
authors.lastname: Miller
authors.forename: Xinli
authors.initials: X
authors.lastname: Zhang
authors.forename: Doug
authors.initials: D
authors.lastname: Carpenter
authors.forename: Chunling
authors.initials: C
authors.lastname: Wang
authors.forename: Kang
authors.initials: K
authors.lastname: Ting
authors.forename: Chia
authors.initials: C
authors.lastname: Soo
mesh_terms: D016475:3T3 Cells; D000818:Animals; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects; D001424:Bacterial Infections / Q000188:drug therapy / Q000209:etiology; D020099:Coated Materials, Biocompatible / Q000737:chemistry / Q000494:pharmacology*; D005269:Femur / Q000000981:diagnostic imaging / Q000254:growth & development / Q000382:microbiology; D019344:Lactic Acid / Q000737:chemistry; D008297:Male; D051379:Mice; D053758:Nanoparticles / Q000737:chemistry; D010006:Osteoblasts / Q000166:cytology; D010012:Osteogenesis; D011100:Polyglycolic Acid / Q000737:chemistry; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D019736:Prostheses and Implants / Q000009:adverse effects; D011859:Radiography; D051381:Rats; D017207:Rats, Sprague-Dawley; D012834:Silver / Q000737:chemistry / Q000494:pharmacology*; D013193:Stainless Steel / Q000737:chemistry
chemical_list: D000900:Anti-Bacterial Agents; D020099:Coated Materials, Biocompatible; D013193:Stainless Steel; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D011100:Polyglycolic Acid; D019344:Lactic Acid; D012834:Silver