title: The characterization and management of Castleman's disease.
abstract: OBJECTIVE
  Castleman's disease (CD) is a rare disorder of unknown aetiology characterized by lymph node enlargement. This study evaluated the clinical features, diagnosis and outcomes of surgical treatment in patients with CD.
  
  
  METHODS
  The medical records of 10 patients with histologically  confirmed CD who underwent surgery between 2003 and 2008 were retrospectively reviewed. Study endpoints were survival and recurrence.
  
  
  RESULTS
  The age of disease onset ranged from 11 to 63 years (median 38 years). Of the 10 patients included in the study, eight were diagnosed with localized  (unicentric) CD and two with multicentric CD. All eight patients with localized (unicentric) CD were asymptomatic. Histological evidence indicated the hyaline vascular form of CD in eight patients and the plasmacytic form in the remaining two patients. The primary treatment was complete surgical  resection in nine cases, and these patients were alive with no evidence of recurrence or exacerbation at the time of writing (June 2011).
  
  
  CONCLUSIONS
  Localized (unicentric) CD is usually of the hyaline vascular form and complete surgical excision of the tumour allows full recovery in most  cases.
authors.affiliation: Department of Dermatology, Changzheng Hospital, and Fudan University, Shanghai, China.
authors.forename: N
authors.initials: N
authors.lastname: Zhou
authors.forename: C W
authors.initials: CW
authors.lastname: Huang
authors.forename: C
authors.initials: C
authors.lastname: Huang
authors.forename: W
authors.initials: W
authors.lastname: Liao
mesh_terms: D000293:Adolescent; D000328:Adult; D005871:Castleman Disease / Q000000981:diagnostic imaging* / Q000601:surgery; D002648:Child; D019468:Disease Management; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011859:Radiography; D012189:Retrospective Studies; D016896:Treatment Outcome; D055815:Young Adult