title: Association of a polymorphism of BTN2A1 with dyslipidemia in East Asian populations.
abstract: We previously identified rs6929846 of the butyrophilin, subfamily 2, member A1 gene (BTN2A1) as a susceptibility locus for myocardial infarction in Japanese individuals by a genome-wide association study. The aim of the present study was to examine the relation of the rs6929846 polymorphism of BTN2A1 to dyslipidemia in Japanese and Korean populations, given that dyslipidemia is an important risk factor for myocardial infarction. A total of 10,953 individuals from three independent subject panels were examined. The relations of the rs6929846 polymorphism of BTN2A1 to serum concentrations of triglycerides, high-density lipoprotein (HDL)-cholesterol and low-density lipoprotein (LDL)-cholesterol were examined in each subject panel. The C→T polymorphism (rs6929846) of BTN2A1 was significantly associated with serum concentrations of triglycerides in Japanese subject panels A (P=0.0004) and B (P=0.0010), and in the Korean population (P=0.0095), with the minor T allele being related to an increased serum concentration of triglycerides. The rs6929846 was associated with serum concentrations of HDL-cholesterol in Japanese subject panels A (P=0.0047) and B (P=0.0015), with the T allele being related to a decreased serum concentration of HDL-cholesterol, but not in the Korean population. This polymorphism was associated with the serum concentration of LDL-cholesterol only in Japanese subject panel B (P=0.0059), with the T allele being related to an increased serum concentration of LDL-cholesterol. The results suggest that BTN2A1 may be a susceptibility gene for hypertriglyceridemia in East Asian populations and for low serum HDL-cholesterol in the Japanese population.
authors.affiliation: Department of Cardiovascular Medicine, Inabe General Hospital, Inabe;
authors.forename: Tetsuo
authors.initials: T
authors.lastname: Fujimaki
authors.forename: Kimihiko
authors.initials: K
authors.lastname: Kato
authors.forename: Mitsutoshi
authors.initials: M
authors.lastname: Oguri
authors.forename: Tetsuro
authors.initials: T
authors.lastname: Yohida
authors.forename: Hideki
authors.initials: H
authors.lastname: Horibe
authors.forename: Kiyoshi
authors.initials: K
authors.lastname: Yokoi
authors.forename: Sachiro
authors.initials: S
authors.lastname: Watanabe
authors.forename: Kei
authors.initials: K
authors.lastname: Satoh
authors.forename: Yukitoshi
authors.initials: Y
authors.lastname: Aoyagi
authors.forename: Masashi
authors.initials: M
authors.lastname: Tanaka
authors.forename: Hiroto
authors.initials: H
authors.lastname: Yoshida
authors.forename: Shoji
authors.initials: S
authors.lastname: Shinkai
authors.forename: Yoshinori
authors.initials: Y
authors.lastname: Nozawa
authors.forename: Dong-Jik
authors.initials: DJ
authors.lastname: Shin
authors.forename: Jong Ho
authors.initials: JH
authors.lastname: Lee
authors.forename: Yangsoo
authors.initials: Y
authors.lastname: Jang
authors.forename: Yoshiji
authors.initials: Y
authors.lastname: Yamada