title: Effect of silymarin on sodium fluoride-induced toxicity and oxidative stress in rat cardiac tissues.
abstract: This study aim to evaluate the protective effect of silymarin on sodium fluoride-induced oxidative stress in rat cardiac tissues. Animals were pretreated with silymarin at 20 and 10 mg/kg prior to sodium fluoride consumption (600 ppm through drinking water). Vitamin C at 10 mg/kg was used as standard antioxidant. There was a significant increase in thiobarbituric acid reactive substances level (59.36 ± 2.19 nmol MDA eq/g tissue) along with a decrease in antioxidant enzymes activity (64.27 ± 1.98 U/g tissue for superoxide dismutase activity and 29.17 ± 1.01 µmol/min/mg protein for catalase activity) and reduced glutathione level (3.8 ± 0.15 µg/mg protein) in the tissues homogenates of the sodium fluoride-intoxicated rats. Silymarin administration to animals before sodium fluoride consumption modified the levels of biochemical parameters.
authors.affiliation: Applied Biotechnology Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran. nabavi208@gmail.com
authors.forename: Seyed M
authors.initials: SM
authors.lastname: Nabavi
authors.forename: Seyed F
authors.initials: SF
authors.lastname: Nabavi
authors.forename: Akbar H
authors.initials: AH
authors.lastname: Moghaddam
authors.forename: William N
authors.initials: WN
authors.lastname: Setzer
authors.forename: Morteza
authors.initials: M
authors.lastname: Mirzaei
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000627:therapeutic use*; D001205:Ascorbic Acid / Q000627:therapeutic use*; D006321:Heart / Q000187:drug effects*; D006801:Humans; D008297:Male; D018384:Oxidative Stress / Q000187:drug effects*; D051381:Rats; D017208:Rats, Wistar; D012838:Silymarin / Q000627:therapeutic use*; D012969:Sodium Fluoride / Q000633:toxicity*
chemical_list: D000975:Antioxidants; D012838:Silymarin; D012969:Sodium Fluoride; D001205:Ascorbic Acid