title: Hyperin and quercetin modulate oxidative stress-induced melanogenesis.
abstract: Hyperin and quercetin are phenolic compounds present in fruits and vegetables that have been reported to possess strong anti-oxidative properties. Although increasing evidence strongly suggests that antioxidants suppress the melanin synthesis that is causally associated with oxidative stress, the protective actions of hyperin and quercetin against oxidative stress-induced melanogenesis have not been fully explored. To elucidate the suppressive effects of hyperin and quercetin on oxidative stress and melanin synthesis, peroxynitrite (ONOO(-)) scavenging activity was measured in vitro as were quantifications of melanin content, intracellular total RS, ONOO(-), superoxide ((•)O(2)), nitric oxide (NO(•)), catalase activity and the reduced glutathione (GSH)/oxidized glutathione (GSSG) ratio. Results showed that in vitro, hyperin and quercetin reduced ONOO(-). Additionally, hyperin and quercetin suppressed total RS, ONOO(-), (•)O(2), and NO(•), catalase activity, and melanin synthesis, while they boosted the GSH/GSSG ratio in B16F10 melanoma cells (B16 cells). Therefore, I propose that hyperin and quercetin have a powerful capacity to modulate oxidative stress-induced melanogenesis.
authors.affiliation: Department of Dental Hygiene, Busan Women's College, Busan 617–734, Korea. yjknutr@yahoo.co.kr
authors.forename: You Jung
authors.initials: YJ
authors.lastname: Kim
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D002374:Catalase / Q000378:metabolism; D045744:Cell Line, Tumor; D005978:Glutathione / Q000378:metabolism; D019803:Glutathione Disulfide / Q000378:metabolism; D008543:Melanins / Q000378:metabolism*; D051379:Mice; D018384:Oxidative Stress / Q000187:drug effects; D011794:Quercetin / Q000031:analogs & derivatives* / Q000494:pharmacology*; D017382:Reactive Oxygen Species / Q000378:metabolism
chemical_list: D000975:Antioxidants; D008543:Melanins; D017382:Reactive Oxygen Species; C021304:hyperoside; D011794:Quercetin; D002374:Catalase; D005978:Glutathione; D019803:Glutathione Disulfide