title: Quaternized chitosan-organic rectorite intercalated composites based nanoparticles for protein controlled release.
abstract: Organic rectorite (OREC) was added in the quaternized chitosan (QC)/alginate (ALG) nanoparticles using an ionic gelation method to fabricate a controllable release system for proteins for the first time. The morphology of nanoparticles, the intercalated structure of OREC, bovine serum albumin encapsulation efficiency and in vitro release properties were investigated. Fourier transform infrared spectra, energy dispersive X-ray, X-ray photoelectron spectroscopy, small angle X-ray diffraction and size distribution analysis were performed to characterize the composite nanoparticles. With the addition of OREC, the encapsulation efficiency and the loading capacity of nanoparticles had increased from 21.2% to 44.9% and from 13.7% to 25.0%, respectively. In addition, the rapid initial release was inhibited successfully from 20.15% to 11.07% in stimulated gastric fluid and from 14.69% to 4.52% in stimulated intestinal fluid. The results verified that the addition of OREC could make these nanoparticles effective carriers to encapsulate drug and slow the drug controlled release of nanoparticles.
authors.affiliation: Department of Anesthesiology, School of Stomatology, Fourth Military Medical University, Xi'an 710032, China.
authors.forename: Ruifen
authors.initials: R
authors.lastname: Xu
authors.forename: Shangjing
authors.initials: S
authors.lastname: Xin
authors.forename: Xue
authors.initials: X
authors.lastname: Zhou
authors.forename: Wei
authors.initials: W
authors.lastname: Li
authors.forename: Feng
authors.initials: F
authors.lastname: Cao
authors.forename: Xuyang
authors.initials: X
authors.lastname: Feng
authors.forename: Hongbing
authors.initials: H
authors.lastname: Deng
mesh_terms: D000464:Alginates / Q000737:chemistry*; D000538:Aluminum Silicates / Q000737:chemistry*; D048271:Chitosan / Q000737:chemistry*; D003692:Delayed-Action Preparations / Q000737:chemistry; D004337:Drug Carriers / Q000737:chemistry*; D005750:Gastric Juice / Q000737:chemistry; D020723:Glucuronic Acid / Q000737:chemistry; D006603:Hexuronic Acids / Q000737:chemistry; D008855:Microscopy, Electron, Scanning; D046529:Microscopy, Electron, Transmission; D008903:Minerals / Q000737:chemistry*; D053758:Nanoparticles / Q000737:chemistry* / Q000648:ultrastructure; D010316:Particle Size; D012710:Serum Albumin, Bovine / Q000737:chemistry*; D017550:Spectroscopy, Fourier Transform Infrared; D014961:X-Ray Diffraction
chemical_list: D000464:Alginates; D000538:Aluminum Silicates; D003692:Delayed-Action Preparations; D004337:Drug Carriers; D006603:Hexuronic Acids; D008903:Minerals; C546376:rectorite; D012710:Serum Albumin, Bovine; D020723:Glucuronic Acid; D048271:Chitosan