title: [Diminished expression of CD5 and/or CD7 surface antigens as the first clue of diagnosis for monoclonal T lymphocytosis].
abstract: The significance of precursor status for mature T-cell neoplasms has not been elucidated. Diagnosis of T-cell neoplasms is often challenging and sometimes overlooked when leukocytosis is not evident and neoplastic cell morphology is hardly distinguishable. Here, we report two cases of monoclonal T lymphocytosis (MTL) without evident lymphocytosis and lymphadenopathies that show slightly diminished CD5 and/or CD7 surface antigens as the first clue of diagnosis. Recently, some reports have demonstrated the possibility that monoclonal lymphocytosis precedes leukemia/lymphoma. Although its clinical significance is unknown, flow cytometric analysis of peripheral blood is useful for detection of occult MTL and careful follow-up is required.
authors.affiliation: Kobe University Graduate School of Medicine, Japan.
authors.forename: Hiroki
authors.initials: H
authors.lastname: Kawano
authors.forename: Kentaro
authors.initials: K
authors.lastname: Minagawa
authors.forename: Kanako
authors.initials: K
authors.lastname: Wakahashi
authors.forename: Yuko
authors.initials: Y
authors.lastname: Kawano
authors.forename: Akiko
authors.initials: A
authors.lastname: Sada
authors.forename: Toshimitsu
authors.initials: T
authors.lastname: Matsui
authors.forename: Yoshio
authors.initials: Y
authors.lastname: Katayama
mesh_terms: D000368:Aged; D015415:Biomarkers / Q000097:blood*; D018956:CD5 Antigens / Q000097:blood*; D005260:Female; D005434:Flow Cytometry; D006801:Humans; D008218:Lymphocytosis / Q000175:diagnosis* / Q000276:immunology; D008297:Male; D008875:Middle Aged; D009419:Nerve Tissue Proteins / Q000097:blood*; D013601:T-Lymphocytes / Q000276:immunology*
chemical_list: D015415:Biomarkers; D018956:CD5 Antigens; C088470:D-7 antigen; D009419:Nerve Tissue Proteins