title: Substitution-free hemodiafiltration.
abstract: Hemodiafiltration (HDF) has been reported to deliver better dialysis outcomes in patients with end-stage renal disease. Technical advances now allow online-based HDF to be used on a clinical basis. However, HDF is being performed at a limited rate because of the requirement of exogenous fluid infusion, which causes safety and cost issues. Therefore, various modifications on HDF strategies have been devised to achieve the HDF without exogenous fluid infusion, which can be achieved by spontaneous fluid reinfusion. In this article, substitution-free HDF strategies are reviewed in detail, with specific attention to technical aspects of the methodology, in vivo and in vitro efficacies, and applicability to clinical use.
authors.affiliation: Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI, USA.
authors.forename: Kyungsoo
authors.initials: K
authors.lastname: Lee
authors.forename: Christopher J
authors.initials: CJ
authors.lastname: Pino
authors.forename: H David
authors.initials: HD
authors.lastname: Humes
mesh_terms: D002986:Clinical Trials as Topic; D017583:Hemodiafiltration / Q000295:instrumentation / Q000379:methods*; D015312:Hemodialysis Solutions; D006439:Hemodynamics; D018056:Hemorheology; D006801:Humans; D007676:Kidney Failure, Chronic / Q000503:physiopathology / Q000628:therapy; D008954:Models, Biological; D011312:Pressure; D016896:Treatment Outcome
chemical_list: D015312:Hemodialysis Solutions