title: Proteasome activity and their subunit composition in endometrial cancer tissue: correlations with clinical morphological parameters.
abstract: The development of endometrial cancer is related to the status of the intracellular proteasome system. Total proteasome activity and pools 26S and 20S activities are higher in tumor tissue than in intact endometrium, and their composition is different. The expression of α1α2α3α5α6α7 is lower in endometrial cancer tissue in comparison with intact endometrium and the content of immune subunits LMP7, LMP2, and PA28β is increased. Total proteasome activity depends on the disease stage.
authors.affiliation: Institute of Oncology, Siberian Division of the Russian Academy of Medical Sciences, Tomsk, Russia. SpirinaLV@oncology.tomsk.ru
authors.forename: L V
authors.initials: LV
authors.lastname: Spirina
authors.forename: I V
authors.initials: IV
authors.lastname: Kondakova
authors.forename: V D
authors.initials: VD
authors.lastname: Koval'
authors.forename: L A
authors.initials: LA
authors.lastname: Kolomiets
authors.forename: A L
authors.initials: AL
authors.lastname: Chernyshova
authors.forename: E L
authors.initials: EL
authors.lastname: Choinzonov
authors.forename: N P
authors.initials: NP
authors.lastname: Sharova
mesh_terms: D004586:Electrophoresis; D016889:Endometrial Neoplasms / Q000378:metabolism* / Q000473:pathology*; D004717:Endometrium / Q000378:metabolism*; D005260:Female; D006801:Humans; D008875:Middle Aged; D046988:Proteasome Endopeptidase Complex / Q000378:metabolism*; D021122:Protein Subunits / Q000378:metabolism*; D018709:Statistics, Nonparametric
chemical_list: D021122:Protein Subunits; D046988:Proteasome Endopeptidase Complex