title: Disease mechanisms in MS: phases of disease improvement unrelated to relapses.
abstract: Natural history of multiple sclerosis includes phases of relapse, remission and insidious progression. New data show that sustained improvements in disease, defined by reductions in EDSS scores, occur independent of relapses almost half as frequently as disease worsening. This finding might facilitate research into the biological processes involved in disease improvement.
authors.affiliation: Institute of Neuroscience and Physiology, University of Gothenburg, Sahlgrenska University Hospital, Sweden. oluf.andersen@neuro.gu.se
authors.forename: Oluf
authors.initials: O
authors.lastname: Andersen
mesh_terms: D002986:Clinical Trials as Topic / Q000639:trends; D018450:Disease Progression; D006801:Humans; D053208:Kaplan-Meier Estimate; D020529:Multiple Sclerosis, Relapsing-Remitting / Q000175:diagnosis* / Q000453:epidemiology / Q000473:pathology; D012008:Recurrence; D012720:Severity of Illness Index