title: Cardiomyocytes derived from human induced pluripotent stem cells as models for normal and diseased cardiac electrophysiology and contractility.
abstract: Since the first description of human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs), these cells have garnered tremendous interest for their potential use in patient-specific analysis and therapy. Additionally, hiPSC-CMs can be derived from donor cells from patients with specific cardiac disorders, enabling in vitro human disease models for mechanistic study and therapeutic drug assessment. However, a full understanding of their electrophysiological and contractile function is necessary before this potential can be realized. Here, we review this emerging field from a functional perspective, with particular emphasis on beating rate, action potential, ionic currents, multicellular conduction, calcium handling and contraction. We further review extant hiPSC-CM disease models that recapitulate genetic myocardial disease.
authors.affiliation: Department of Biomedical Engineering, The Johns Hopkins University, 720 Rutland Ave., Baltimore, MD 21205, USA.
authors.forename: Adriana
authors.initials: A
authors.lastname: Blazeski
authors.forename: Renjun
authors.initials: R
authors.lastname: Zhu
authors.forename: David W
authors.initials: DW
authors.lastname: Hunter
authors.forename: Seth H
authors.initials: SH
authors.lastname: Weinberg
authors.forename: Elias T
authors.initials: ET
authors.lastname: Zambidis
authors.forename: Leslie
authors.initials: L
authors.lastname: Tung
mesh_terms: D000818:Animals; D055724:Electrophysiological Phenomena; D006321:Heart / Q000502:physiology / Q000503:physiopathology; D006331:Heart Diseases / Q000473:pathology* / Q000503:physiopathology*; D006801:Humans; D057026:Induced Pluripotent Stem Cells / Q000166:cytology* / Q000473:pathology; D019344:Lactic Acid; D009200:Myocardial Contraction; D032383:Myocytes, Cardiac / Q000166:cytology* / Q000473:pathology
chemical_list: C006756:biolactin; D019344:Lactic Acid