title: Stretch-induced biodegradation of polyelectrolyte multilayer films for drug release.
abstract: The design of stimuli-responsive polymer assemblies for the controlled release of bioactive molecules has raised considerable interest these two last decades. Herein, we report the design of mechanically responsive drug-releasing films made of polyelectrolyte multilayers. A layer-by-layer (LbL) reservoir containing biodegradable polyelectrolytes is capped with a mechanosensitive LbL barrier and responds to stretching by a total enzymatic degradation of the film. This strategy is successfully applied for the release in solution of an anticancer drug initially loaded within the architecture.
authors.affiliation: Institut National de la Santé et de la Recherche Médicale, INSERM Unité 977, 11 rue Humann, 67085 Strasbourg Cedex, France.
authors.forename: Julien
authors.initials: J
authors.lastname: Barthes
authors.forename: Damien
authors.initials: D
authors.lastname: Mertz
authors.forename: Charlotte
authors.initials: C
authors.lastname: Bach
authors.forename: Marie-Hélène
authors.initials: MH
authors.lastname: Metz-Boutigue
authors.forename: Bernard
authors.initials: B
authors.lastname: Senger
authors.forename: Jean-Claude
authors.initials: JC
authors.lastname: Voegel
authors.forename: Pierre
authors.initials: P
authors.lastname: Schaaf
authors.forename: Philippe
authors.initials: P
authors.lastname: Lavalle
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000378:metabolism*; D004573:Electrolytes / Q000737:chemistry / Q000378:metabolism; D008567:Membranes, Artificial; D008968:Molecular Conformation; D017239:Paclitaxel / Q000737:chemistry / Q000378:metabolism*; D011108:Polymers / Q000737:chemistry / Q000378:metabolism*; D013314:Stress, Mechanical
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D004573:Electrolytes; D008567:Membranes, Artificial; D011108:Polymers; D017239:Paclitaxel