title: Apple can act as anti-aging on yeast cells.
abstract: In recent years, epidemiological and biochemical studies have shown that eating apples is associated with reduction of occurrence of cancer, degenerative, and cardiovascular diseases. This association is often attributed to the presence of antioxidants such as ascorbic acid (vitamin C) and polyphenols. The substances that hinder the presence of free radicals are also able to protect cells from aging. In our laboratory we used yeast, a unicellular eukaryotic organism, to determine in vivo efficacy of entire apples and their components, such as flesh, skin and polyphenolic fraction, to influence aging and oxidative stress. Our results indicate that all the apple components increase lifespan, with the best result given by the whole fruit, indicating a cooperative role of all apple components.
authors.affiliation: Dipartimento di Biologia e Biotecnologie Charles Darwin, Istituto Pasteur-Fondazione Cenci Bolognetti, Sapienza Università di Roma, Piazzale Aldo Moro 5, 00185 Roma, Italy.
authors.forename: Vanessa
authors.initials: V
authors.lastname: Palermo
authors.forename: Fulvio
authors.initials: F
authors.lastname: Mattivi
authors.forename: Romano
authors.initials: R
authors.lastname: Silvestri
authors.forename: Giuseppe
authors.initials: G
authors.lastname: La Regina
authors.forename: Claudio
authors.initials: C
authors.lastname: Falcone
authors.forename: Cristina
authors.initials: C
authors.lastname: Mazzoni
mesh_terms: D001205:Ascorbic Acid / Q000737:chemistry / Q000494:pharmacology; D002470:Cell Survival / Q000187:drug effects; D016922:Cellular Senescence / Q000187:drug effects; D005638:Fruit / Q000737:chemistry; D027845:Malus / Q000737:chemistry*; D018384:Oxidative Stress / Q000187:drug effects; D059808:Polyphenols / Q000737:chemistry / Q000494:pharmacology; D017382:Reactive Oxygen Species / Q000378:metabolism; D012441:Saccharomyces cerevisiae / Q000187:drug effects*
chemical_list: D059808:Polyphenols; D017382:Reactive Oxygen Species; D001205:Ascorbic Acid