title: Lignans and triterpenes from the root of Pseuderanthemum carruthersii var. atropurpureum.
abstract: Two new lignans, pseuderesinol (1), pseuderanoside (2) and a new triterpene, pseuderanic acid (3) were isolated from the dried root of Pseuderanthemum carruthersii (SEEM.) GUILL. var. atropurpureum (BULL.) FOSB. (Acanthaceae), together with ten known compounds, including five lignans, (+)-eudesmin (4), (+)-magnolin (5), (+)-syringaresinol (6), (+)-episyringaresinol (7), (+)-1-hydroxysyringaresinol (8) and five triterpenes, squalene (9), oleanolic acid (10), lupeol (11), betulin (12), betulinic acid (13). Their chemical structures were elucidated by 1D- and 2D-NMR, computational quantum chemistry, as well as high resolution-electrospray ionization (HR-ESI)-MS spectroscopic analysis. The acetylcholinesterase inhibition and cytotoxic activities against HeLa and MCF-7 cancer cell lines were evaluated on some purified compounds at the concentration of 100 µg/mL. Pseuderesinol (1) and magnolin (5) exhibited moderate cytotoxic activities against the MCF-7 cancer cell line.
authors.affiliation: Department of Chemical-Food Technology, University of Technical Education-Ho Chi Minh City, 1 Vo Van Ngan Str., Thu Duc Dist., Ho Chi Minh 720059, Vietnam.
authors.forename: Thi Nga
authors.initials: TN
authors.lastname: Vo
authors.forename: Phi Linh
authors.initials: PL
authors.lastname: Nguyen
authors.forename: Lam Truong
authors.initials: LT
authors.lastname: Tuong
authors.forename: Lawrence Michael
authors.initials: LM
authors.lastname: Pratt
authors.forename: Phung Nguyen
authors.initials: PN
authors.lastname: Vo
authors.forename: Kim Phi Phung
authors.initials: KP
authors.lastname: Nguyen
authors.forename: Ngoc Suong
authors.initials: NS
authors.lastname: Nguyen
mesh_terms: D027901:Acanthaceae / Q000737:chemistry*; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D006801:Humans; D017705:Lignans / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D009369:Neoplasms / Q000188:drug therapy; D018517:Plant Roots / Q000737:chemistry*; D014315:Triterpenes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D017705:Lignans; D014315:Triterpenes