title: Convenient syntheses of 1,2-trans selenoglycosides using isoselenuronium salts as glycosylselenenyl transfer reagents.
abstract: Se-glycosyl-isoselenuronium salts such as three and four which can be prepared in one high-yielding step from acetohalogeno sugars proved to be convenient starting materials for the syntheses of a variety of selenoglycosides. Reaction with (ar)alkyl halides proceeds under mild conditions, in short time, at room temperature to afford the corresponding selenoglycosides in good yields. Aryl halides react to appreciable extent only if bearing activating nitro groups on the aromatic ring. Reactions with acylating reagents such as acetic anhydride and benzoyl chlorides furnished anomeric selenoesters some of which were recently proposed as starting compounds for alternative selenoglycoside syntheses. Selenodisaccharides with two different monosaccharide units could also be prepared via reactions of glycosyl-isoselenuronium salts with monosaccharide derivatives bearing primary or secondary triflate groups.
authors.affiliation: Department of Organic Chemistry, University of Debrecen, H-4010 Debrecen Pf 20, Hungary.
authors.forename: Ambati Ashok
authors.initials: AA
authors.lastname: Kumar
authors.forename: Tünde Zita
authors.initials: TZ
authors.lastname: Illyés
authors.forename: Katalin E
authors.initials: KE
authors.lastname: Kövér
authors.forename: László
authors.initials: L
authors.lastname: Szilágyi
mesh_terms: D006027:Glycosides / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D016566:Organoselenium Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D012492:Salts / Q000737:chemistry
chemical_list: D006027:Glycosides; D016566:Organoselenium Compounds; D012492:Salts