title: Community cluster of meningococcal disease by Neisseria meningitidis serogroup C in Andalusia, Spain, March to May 2011.
abstract: Between March and May of 2011, a cluster of three fatal cases of meningococcal sepsis occurred in Andalusia, Spain, in a municipality with a population of around 20,000 inhabitants. The cases were in their mid-teens to early thirties and were notified to the epidemiological surveillance system of Andalusia (Sistema de Vigilancia Epidemiológica de Andalucía, SVEA) during a 68-day period from March through May 2011. All three were infected with the same strain of Neisseria meningitidis serogroup C genosubtype VR1:5-1;VR2:10-8. None of the cases had been previously vaccinated against N. meningitidis serogroup C. Antibiotic post-exposure chemoprophylaxis was administered to close contacts of every diagnosed case. Once the cluster was confirmed, the local population was informed through the media about the control measures taken by the health authorities. The vaccination history against N. meningitidis serogroup C of the population under 25 years-old in the municipality was checked. Vaccination was offered to unimmunised individuals younger than 25 years of age and an additional dose of vaccine was offered to those who had been vaccinated between 2000 and 2006 with a vaccination schedule of three doses before the first year of age. No further cases occurred since the beginning of these actions.
authors.affiliation: Regional Ministry of Health of the Government of Andalusia, Seville, Spain. josem.mayoral.sspa@juntadeandalucia.es
authors.forename: J M
authors.initials: JM
authors.lastname: Mayoral Cortés
authors.forename: E
authors.initials: E
authors.lastname: Torres Butrón
authors.forename: M
authors.initials: M
authors.lastname: García Fernández
authors.forename: Z
authors.initials: Z
authors.lastname: Herrador Ortiz
authors.forename: S
authors.initials: S
authors.lastname: Huarte Osakar
authors.forename: R
authors.initials: R
authors.lastname: Santos Luque
authors.forename: E
authors.initials: E
authors.lastname: Pérez Morilla
authors.forename: J
authors.initials: J
authors.lastname: Guillén Enriquez
mesh_terms: D000293:Adolescent; D000328:Adult; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D016000:Cluster Analysis; D016358:Contact Tracing; D018563:Disease Notification; D004196:Disease Outbreaks / Q000517:prevention & control*; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D008297:Male; D008589:Meningococcal Infections / Q000175:diagnosis* / Q000188:drug therapy / Q000453:epidemiology / Q000517:prevention & control; D022401:Meningococcal Vaccines / Q000008:administration & dosage; D038542:Neisseria meningitidis, Serogroup C / Q000235:genetics / Q000302:isolation & purification*; D056990:Post-Exposure Prophylaxis; D012189:Retrospective Studies; D018805:Sepsis / Q000209:etiology; D012703:Serotyping; D013030:Spain / Q000453:epidemiology; D014505:Urban Population; D014611:Vaccination; D055815:Young Adult
chemical_list: D000900:Anti-Bacterial Agents; D022401:Meningococcal Vaccines