title: Haemocompatibility testing of biomaterials using human platelets.
abstract: Cardiovascular implants are increasingly important in regenerative medicine. To improve the safety and function of blood-contacting implants a major need exists for new polymer-based biomaterials that avoid adverse reactions, particularly thrombotic events. This review is aimed to summarize the multi-stepped and interlinked processes leading to a thrombus growth on body foreign surfaces: protein adsorption, platelet adhesion accompanied by activation and spreading and the release of substances of various organelles activating other neighboured platelets (and the plasmatic coagulation) leading to the formation of a plug of platelets and, finally, to a thrombus.
authors.affiliation: Center for Biomaterial Development and Berlin-Brandenburg Centre for Regenerative Therapies (BCRT), Institute of Polymer Research, Helmholtz-Zentrum Geesthacht, Teltow, Germany. friedrich.jung@hzg.de
authors.forename: F
authors.initials: F
authors.lastname: Jung
authors.forename: S
authors.initials: S
authors.lastname: Braune
authors.forename: A
authors.initials: A
authors.lastname: Lendlein
mesh_terms: D000327:Adsorption; D001672:Biocompatible Materials; D001792:Blood Platelets / Q000378:metabolism*; D005547:Foreign Bodies / Q000378:metabolism; D006801:Humans; D008422:Materials Testing / Q000379:methods*; D015539:Platelet Activation; D010973:Platelet Adhesiveness; D019736:Prostheses and Implants / Q000009:adverse effects; D013499:Surface Properties; D013927:Thrombosis / Q000209:etiology / Q000517:prevention & control
chemical_list: D001672:Biocompatible Materials