title: Risk factors for the incidence of dengue virus infection in preschool children.
abstract: OBJECTIVE
  To estimate the seroincidence of dengue in children living in Salvador, Bahia, Brazil and to evaluate the factors associated.
  
  
  METHODS
  A prospective serological survey was carried out in a sample of children 0-3 years of age. A multilevel logistic model was used to identify the determinants of seroincidence.
  
  
  RESULTS
  The seroprevalence of dengue was 26.6% in the 625 children evaluated. A second survey detected an incidence of 33.2%. Multilevel logistic regression showed a statistically significant association between the seroincidence of dengue and age and the premises index.
  
  
  CONCLUSIONS
  In Salvador, the dengue virus is in active circulation during early childhood; consequently, children have heterotypic antibodies and run a high risk of developing dengue haemorrhagic fever, because the sequence and intensity of the three dengue virus serotypes currently circulating in this city are very similar to those that were circulating in Rio de Janeiro, Brazil, in 2008. Therefore, the authors strongly recommend that the health authorities in cities with a similar epidemiological scenario be aware of this risk and implement improvements in health care, particularly targeting the paediatric age groups. In addition, information should be provided to the population and actions should be implemented to combat this vector.
authors.affiliation: Instituto de Saúde Coletiva, Federal University of Bahia, Salvador, Bahia, Brazil  Faculdade de Medicina, Federal University of Bahia, Salvador, Bahia, Brazil.
authors.forename: Maria G
authors.initials: MG
authors.lastname: Teixeira
authors.forename: Vanessa
authors.initials: V
authors.lastname: Morato
authors.forename: Florisneide R
authors.initials: FR
authors.lastname: Barreto
authors.forename: Carlos M C
authors.initials: CM
authors.lastname: Mendes
authors.forename: Maurício L
authors.initials: ML
authors.lastname: Barreto
authors.forename: Maria da Conceição N
authors.initials: Mda C
authors.lastname: Costa
mesh_terms: D001938:Brazil / Q000453:epidemiology; D002675:Child, Preschool; D003715:Dengue / Q000453:epidemiology* / Q000821:virology; D003716:Dengue Virus / Q000302:isolation & purification*; D005260:Female; D006801:Humans; D015994:Incidence; D007223:Infant; D016015:Logistic Models; D008297:Male; D011446:Prospective Studies; D012307:Risk Factors; D016036:Seroepidemiologic Studies; D012959:Socioeconomic Factors