title: IVUS detection of vasa vasorum blood flow distribution in coronary artery vessel wall.
abstract: There is an increased body of evidence to suggest that the vasa vasorum play a major role in the progression and complications of vulnerable plaque leading to acute coronary syndrome. We propose that detecting changes in the flow in the vascular wall by intravascular ultrasound signals can quantify the presence of vasa vasorum. The results obtained in a porcine model of atherosclerosis suggest that intravascular ultrasound-based estimates of blood flow in the arterial wall can be used in vivo in a clinical research setting to establish the density of vasa vasorum as an indicator of plaque vulnerability.
authors.affiliation: Department of Physiology and Biomedical Engineering, Mayo Clinic College of Medicine, Rochester, Minnesota 55902, USA.
authors.forename: Regina
authors.initials: R
authors.lastname: Moritz
authors.forename: Diane R
authors.initials: DR
authors.lastname: Eaker
authors.forename: Jill L
authors.initials: JL
authors.lastname: Anderson
authors.forename: Timothy L
authors.initials: TL
authors.lastname: Kline
authors.forename: Steven M
authors.initials: SM
authors.lastname: Jorgensen
authors.forename: Amir
authors.initials: A
authors.lastname: Lerman
authors.forename: Erik L
authors.initials: EL
authors.lastname: Ritman
mesh_terms: D000818:Animals; D003324:Coronary Artery Disease / Q000000981:diagnostic imaging* / Q000503:physiopathology; D003326:Coronary Circulation; D003331:Coronary Vessels / Q000000981:diagnostic imaging* / Q000503:physiopathology; D004195:Disease Models, Animal; D042241:Early Diagnosis; D005240:Feasibility Studies; D005260:Female; D058226:Plaque, Atherosclerotic; D011237:Predictive Value of Tests; D034421:Sus scrofa; D018084:Ultrasonography, Interventional; D014651:Vasa Vasorum / Q000000981:diagnostic imaging* / Q000503:physiopathology