title: CC chemokine receptor 5 polymorphism in Italian patients with Behcet's disease.
abstract: OBJECTIVE
  To evaluate the potential role of CC chemokine receptor 5 (CCR5)Δ32 polymorphism in the susceptibility to and clinical expression of Behçet's disease (BD) in a cohort of Italian patients.
  
  
  METHODS
  One hundred and ninety-six consecutive Italian patients satisfying the ISG criteria for BD were followed up for 8 years, and 180 healthy age- and sex-matched blood donors were molecularly genotyped for the CCR5Δ32 polymorphism. A standard microlymphocytotoxicity technique was used to serotype HLA-B51. The patients were subgrouped on the basis of the presence or absence of clinical manifestations.
  
  
  RESULTS
  The distribution of the CCR5Δ32 genotype differed between BD patients and controls (P = 0.02). The CCR5Δ32 allele was more common in BD patients than in controls [P = 0.02, odds ratio (OR) 2.28 (95% CI 1.1, 4.8)]. Carriers of the CCR5Δ32 allele (Δ32/Δ32 + CCR5/Δ32) were significantly more common in BD patients than in controls [P = 0.02, OR 2.37 (95% CI 1.1, 5.1)]. Population-attributable risk was 7.1%. In categorizing patients according to gender, the association between CCR5Δ32 polymorphism and BD was similar in females and males (ORs 2.76 and 2.0, respectively). No significant differences were found when the frequencies of clinical manifestations were compared between CC5RΔ32 allele carriers and non-carriers.
  
  
  CONCLUSIONS
  CCR5Δ32 polymorphism is associated with an increased susceptibility to develop BD. Chemokines may have a role in the pathophysiology of BD.
authors.affiliation: Rheumatology Unit, L. Sacco University Hospital, Milan, Italy.
authors.forename: Fabiola
authors.initials: F
authors.lastname: Atzeni
authors.forename: Luigi
authors.initials: L
authors.lastname: Boiardi
authors.forename: Bruno
authors.initials: B
authors.lastname: Casali
authors.forename: Enrico
authors.initials: E
authors.lastname: Farnetti
authors.forename: Davide
authors.initials: D
authors.lastname: Nicoli
authors.forename: Piercarlo
authors.initials: P
authors.lastname: Sarzi-Puttini
authors.forename: Nicolò
authors.initials: N
authors.lastname: Pipitone
authors.forename: Ignazio
authors.initials: I
authors.lastname: Olivieri
authors.forename: Fabrizio
authors.initials: F
authors.lastname: Cantini
authors.forename: Fabrizio
authors.initials: F
authors.lastname: Salvi
authors.forename: Renato
authors.initials: R
authors.lastname: La Corte
authors.forename: Giovanni
authors.initials: G
authors.lastname: Triolo
authors.forename: Davide
authors.initials: D
authors.lastname: Filippini
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Paolazzi
authors.forename: Carlo
authors.initials: C
authors.lastname: Salvarani
mesh_terms: D000328:Adult; D001528:Behcet Syndrome / Q000208:ethnology / Q000235:genetics*; D016022:Case-Control Studies; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D015235:HLA-B Antigens / Q000235:genetics; D006579:Heterozygote; D006720:Homozygote; D006801:Humans; D007558:Italy / Q000208:ethnology; D008297:Male; D011110:Polymorphism, Genetic / Q000235:genetics*; D019713:Receptors, CCR5 / Q000235:genetics*
chemical_list: D015235:HLA-B Antigens; C103707:HLA-B57 antigen; D019713:Receptors, CCR5