title: [Amino acids content in the blood serum of patients with multiple sclerosis].
abstract: Content of amino acids in the blood serum using ion-exchange chromatography and a quantitative crystalloscopic "closed drop" method was measured in 105 patients with multiple sclerosis of different severity. The relation between the dynamics of content of glutamic, asparagine acids and glycine and the disease severity was determined. The highest level of glutamic acid was found in the patients with severe disease course. The dynamics of quantitative changes in the amino acid content was accompanied by the disturbance of blood serum structuration and appearance of selective micromorphotypes. The positive correlation between the severity of motor and coordination disorders and the increase in levels of glutamic acid and glycine in the severe cases was detected.
authors.forename: E M
authors.initials: EM
authors.lastname: Ivanova
authors.forename: M A
authors.initials: MA
authors.lastname: Barabanova
authors.forename: G G
authors.initials: GG
authors.lastname: Muzlaev
authors.forename: T A
authors.initials: TA
authors.lastname: Petropavlovskaia
authors.forename: O V
authors.initials: OV
authors.lastname: Stoianova
mesh_terms: D000328:Adult; D001224:Aspartic Acid / Q000097:blood*; D002852:Chromatography, Ion Exchange; D005260:Female; D018698:Glutamic Acid / Q000097:blood*; D005998:Glycine / Q000097:blood*; D006801:Humans; D008297:Male; D009103:Multiple Sclerosis / Q000097:blood* / Q000503:physiopathology*; D012720:Severity of Illness Index
chemical_list: D001224:Aspartic Acid; D018698:Glutamic Acid; D005998:Glycine