title: The mitochondrial SIRT1-PGC-1α axis in podocyte injury.
abstract: Dysfunction of mitochondria in podocytes is believed to be a trigger of injury and contributes to progressive glomerular sclerosis; however, the mechanisms had not been fully understood. Yuan et al. report involvement of SIRT1 (a homolog of the life-extending gene sir2 in mammals) and PPAR-γ coactivator 1α, a major regulator of oxidative metabolism, in mitochondria during podocyte injury. This information will be important in exploration of the mechanisms and future treatment of glomerular sclerosis.
authors.affiliation: Department of Nephrology, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan.
authors.forename: Shuichi
authors.initials: S
authors.lastname: Tsuruoka
authors.forename: Akira
authors.initials: A
authors.lastname: Hiwatashi
authors.forename: Joichi
authors.initials: J
authors.lastname: Usui
authors.forename: Kunihiro
authors.initials: K
authors.lastname: Yamagata
mesh_terms: D000450:Aldosterone; D000818:Animals; D017209:Apoptosis; D007674:Kidney Diseases / Q000517:prevention & control*; D008928:Mitochondria / Q000378:metabolism*; D000071248:Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; D050199:Podocytes / Q000378:metabolism*; D015534:Trans-Activators / Q000378:metabolism*; D014157:Transcription Factors
chemical_list: D000071248:Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; C485290:Ppargc1a protein, mouse; D015534:Trans-Activators; D014157:Transcription Factors; D000450:Aldosterone