title: [Reseanh advance in human astrovirus].
abstract: Human astroviruses have been recognized as one of the important causes of viral gastroenteritis in infants and young children. In the present work, we reviewed the progress of astrovirus infections in humans, focusing on the serotypes molecular biological, characteristics of disease, pathogenic mechanism, epidemiology and detection methods, and concluded that there were multiple astroviruses circulating in the world, and several novel astroviruses were discovered in recent years. Human astrovirus 1 was the most prevailing serotype. Which caused intestinal and parenteral infections, and the characteristics of infections were similar to other diarrheal viruses. However, the pathogenic mechanism remained unknown. Only limited data was available about the correlation between the novel astroviruses and diseases, and the laboratory detection methods needed to be established.
authors.affiliation: Department of Pediatrics, The First Clinical Medical School of Lanzhou University, Lanzhou 730000, China. libertywang@126.com
authors.forename: Yong-Xia
authors.initials: YX
authors.lastname: Wang
authors.forename: Zhao-Jun
authors.initials: ZJ
authors.lastname: Duan
authors.forename: Yu-Ning
authors.initials: YN
authors.lastname: Li
mesh_terms: D000818:Animals; D019350:Astroviridae Infections / Q000175:diagnosis / Q000453:epidemiology / Q000473:pathology; D002460:Cell Line; D016679:Genome, Viral / Q000235:genetics; D006801:Humans; D001257:Mamastrovirus / Q000145:classification / Q000235:genetics / Q000472:pathogenicity / Q000502:physiology; D014779:Virus Replication