title: A population-based study of the risk of repeat clinical chorioamnionitis in Washington State, 1989-2008.
abstract: OBJECTIVE
  Chorioamnionitis can cause severe complications for the infant; therefore, characterization of the risk of recurrence and identification of the factors that modify it are clinically relevant to pregnant women and their providers.
  
  
  METHODS
  The risk of recurrence was examined in a retrospective population-based cohort study with the use of birth certificate and delivery hospitalization discharge data from Washington State for the years 1989-2008.
  
  
  RESULTS
  Women who had chorioamnionitis in their first deliveries were 3.43 times as likely to have chorioamnionitis in their second deliveries as were women who did not have chorioamnionitis in their first deliveries (95% confidence interval [CI], 2.67-4.42; P < .001). Smoking status modified this association (smokers: odds ratio, 1.38 [95% CI, 0.62-3.08]; nonsmokers: odds ratio, 3.80 [95% CI, 2.88-5.00]).
  
  
  CONCLUSIONS
  These data provide strong evidence for the occurrence of repeat chorioamnionitis; the association is strongest in women who do not smoke during pregnancy.
authors.affiliation: Department of Epidemiology, School of Public Health, University of Washington, Seattle, WA, USA.
authors.forename: Hannah N
authors.initials: HN
authors.lastname: Cohen-Cline
authors.forename: Talia R
authors.initials: TR
authors.lastname: Kahn
authors.forename: Carolyn M
authors.initials: CM
authors.lastname: Hutter
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D002821:Chorioamnionitis / Q000175:diagnosis / Q000453:epidemiology*; D015331:Cohort Studies; D005260:Female; D005322:Premature Rupture of Fetal Membranes / Q000453:epidemiology; D006801:Humans; D015994:Incidence; D011247:Pregnancy; D012008:Recurrence; D012189:Retrospective Studies; D018570:Risk Assessment; D012907:Smoking / Q000453:epidemiology; D014861:Washington / Q000453:epidemiology; D055815:Young Adult