title: Dealcoholized red wine decreases systolic and diastolic blood pressure and increases plasma nitric oxide: short communication.
abstract: BACKGROUND
  Experimental studies have shown a potential blood pressure (BP) lowering effect of red wine polyphenols, whereas the effects of ethanol and polyphenols on BP in humans are not yet clear.
  
  
  OBJECTIVE
  The aim of the present work was to evaluate the effects of red wine fractions (alcoholic and nonalcoholic) on BP and plasma nitric oxide (NO) in subjects at high cardiovascular risk.
  
  
  RESULTS
  Sixty-seven men at high cardiovascular risk were studied. After a 2-week run-in period, subjects were randomized into 3 treatment periods in a crossover clinical trial, with a common background diet plus red wine (30g alcohol/day), the equivalent amount of dealcoholized red wine, or gin (30g alcohol/day), lasting 4 weeks each intervention. At baseline and after each intervention, anthropometrical parameters, BP and plasma NO were measured. Systolic and diastolic BP decreased significantly after the dealcoholized red wine intervention and these changes correlated with increases in plasma NO.
  
  
  CONCLUSIONS
  Dealcoholized red wine decreases systolic and diastolic BP. Our results point out through an NO-mediated mechanism. The daily consumption of dealcoholized red wine could be useful for the prevention of low to moderate hypertension. Trial registered at controlled-trials.com: ISRCTN88720134.
authors.affiliation: Department of Internal Medicine, Hospital Clínic, Institut d'Investigacions Biomèdiques August Pi i Sunyer, University of Barcelona, Barcelona, Spain.
authors.forename: Gemma
authors.initials: G
authors.lastname: Chiva-Blanch
authors.forename: Mireia
authors.initials: M
authors.lastname: Urpi-Sarda
authors.forename: Emilio
authors.initials: E
authors.lastname: Ros
authors.forename: Sara
authors.initials: S
authors.lastname: Arranz
authors.forename: Palmira
authors.initials: P
authors.lastname: Valderas-Martínez
authors.forename: Rosa
authors.initials: R
authors.lastname: Casas
authors.forename: Emilio
authors.initials: E
authors.lastname: Sacanella
authors.forename: Rafael
authors.initials: R
authors.lastname: Llorach
authors.forename: Rosa M
authors.initials: RM
authors.lastname: Lamuela-Raventos
authors.forename: Cristina
authors.initials: C
authors.lastname: Andres-Lacueva
authors.forename: Ramon
authors.initials: R
authors.lastname: Estruch
mesh_terms: D000368:Aged; D001794:Blood Pressure / Q000187:drug effects* / Q000502:physiology; D002492:Central Nervous System Depressants / Q000008:administration & dosage; D018592:Cross-Over Studies; D000431:Ethanol / Q000008:administration & dosage; D006801:Humans; D006973:Hypertension / Q000188:drug therapy* / Q000453:epidemiology / Q000517:prevention & control; D008297:Male; D008875:Middle Aged; D009569:Nitric Oxide / Q000097:blood*; D059808:Polyphenols / Q000008:administration & dosage*; D012307:Risk Factors; D040242:Risk Reduction Behavior; D016896:Treatment Outcome; D014920:Wine
chemical_list: D002492:Central Nervous System Depressants; D059808:Polyphenols; D009569:Nitric Oxide; D000431:Ethanol