title: Dendrimers as vectors for genetic material delivery to the nervous system.
abstract: Transfection of genetic material into primary neuronal cultures remains a challenge because of the intrinsic difficulty in transfecting this type of cell. This review covers the recent developments in the use of dendrimers for siRNA and DNA transfection in both neuronal and glial cells. Crossing the blood brain barrier crossing represents a challenge for the effective use of dendrimer-mediated delivery of therapeutic agents to the central nervous system. We will discuss the effectiveness, both in vitro and in vivo, of various dendrimers in delivering genetic material to neural tissue and its ability to cross the blood-brain barrier. In addition, the use of dendrimers as a potential new therapy in the treatment of glioblastoma will be presented.
authors.affiliation: Unidad Asociada Neurodeath, CSIC-Universidad de Castilla-La Mancha, Departamento de Ciencias Médicas, Albacete, Spain.
authors.forename: F C
authors.initials: FC
authors.lastname: Pérez-Martínez
authors.forename: A V
authors.initials: AV
authors.lastname: Ocaña
authors.forename: M D
authors.initials: MD
authors.lastname: Pérez-Carrión
authors.forename: V
authors.initials: V
authors.lastname: Ceña
mesh_terms: D000818:Animals; D001812:Blood-Brain Barrier / Q000378:metabolism; D050091:Dendrimers / Q000008:administration & dosage / Q000737:chemistry* / Q000493:pharmacokinetics; D004337:Drug Carriers / Q000008:administration & dosage / Q000737:chemistry / Q000493:pharmacokinetics; D018014:Gene Transfer Techniques; D005822:Genetic Vectors / Q000008:administration & dosage / Q000737:chemistry* / Q000493:pharmacokinetics; D006801:Humans; D014162:Transfection
chemical_list: D050091:Dendrimers; D004337:Drug Carriers