title: Highly enantioselective synthesis of warfarin and its analogs catalysed by primary amine-phosphinamide bifunctional catalysts.
abstract: An efficient enantioselective Michael addition of 4-hydroxycoumarin to α,β-unsaturated ketones catalysed by primary amine-phosphinamide bifunctional catalysts has been developed. This reaction afforded Warfarin and its analogs in moderate to excellent yields (up to 99%) and good to excellent enantioselectivities (up to 99% ee).
authors.affiliation: School of Chemical Engineering and Environment, Beijing Institute of Technology, Beijing 100081, People's Republic of China.
authors.forename: Juan
authors.initials: J
authors.lastname: Dong
authors.forename: Da-Ming
authors.initials: DM
authors.lastname: Du
mesh_terms: D000577:Amides / Q000737:chemistry*; D000588:Amines / Q000737:chemistry*; D002384:Catalysis; D015394:Molecular Structure; D009943:Organophosphorus Compounds / Q000737:chemistry*; D013237:Stereoisomerism; D014859:Warfarin / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D000577:Amides; D000588:Amines; D009943:Organophosphorus Compounds; D014859:Warfarin