title: Physical training prevents oxidative stress in L-NAME-induced hypertension rats.
abstract: The present study investigated the effects of a 6-week swimming training on blood pressure, nitric oxide (NO) levels and oxidative stress parameters such as protein and lipid oxidation, antioxidant enzyme activity and endogenous non-enzymatic antioxidant content in kidney and circulating fluids, as well as on serum biochemical parameters (cholesterol, triglycerides, urea and creatinine) from Nω-nitro-L-arginine methyl ester hydrochloride (L-NAME)-induced hypertension treated rats. Animals were divided into four groups (n = 10): Control, Exercise, L-NAME and Exercise L-NAME. Results showed that exercise prevented a decrease in NO levels in hypertensive rats (P < 0·05). An increase in protein and lipid oxidation observed in the L-NAME-treated group was reverted by physical training in serum from the Exercise L-NAME group (P < 0·05). A decrease in the catalase (CAT) and superoxide dismutase (SOD) activities in the L-NAME group was observed when compared with normotensive groups (P < 0·05). In kidney, exercise significantly augmented the CAT and SOD activities in the Exercise L-NAME group when compared with the L-NAME group (P < 0·05). There was a decrease in the non-protein thiols (NPSH) levels in the L-NAME-treated group when compared with the normotensive groups (P < 0·05). In the Exercise L-NAME group, there was an increase in NPSH levels when compared with the L-NAME group (P < 0·05). The elevation in serum cholesterol, triglycerides, urea and creatinine levels observed in the L-NAME group were reverted to levels close to normal by exercise in the Exercise L-NAME group (P < 0·05). Exercise training had hypotensive effect, reducing blood pressure in the Exercise L-NAME group (P < 0·05). These findings suggest that physical training could have a protector effect against oxidative damage and renal injury caused by hypertension.
authors.affiliation: Post-Graduation Program in Toxicological Biochemistry, Department of Chemistry of the Center of Natural and Exact Sciences, Federal University of Santa Maria, Santa Maria, RS, Brazil.
authors.forename: Andréia Machado
authors.initials: AM
authors.lastname: Cardoso
authors.forename: Caroline Curry
authors.initials: CC
authors.lastname: Martins
authors.forename: Fernando da Silva
authors.initials: Fda S
authors.lastname: Fiorin
authors.forename: Roberta
authors.initials: R
authors.lastname: Schmatz
authors.forename: Fátima Husein
authors.initials: FH
authors.lastname: Abdalla
authors.forename: Jessié
authors.initials: J
authors.lastname: Gutierres
authors.forename: Daniela
authors.initials: D
authors.lastname: Zanini
authors.forename: Amanda Maino
authors.initials: AM
authors.lastname: Fiorenza
authors.forename: Naiara
authors.initials: N
authors.lastname: Stefanello
authors.forename: Jonas Daci da Silva
authors.initials: JD
authors.lastname: Serres
authors.forename: Fabiano
authors.initials: F
authors.lastname: Carvalho
authors.forename: Verônica Paiva
authors.initials: VP
authors.lastname: Castro
authors.forename: Cinthia Melazzo
authors.initials: CM
authors.lastname: Mazzanti
authors.forename: Luiz Fernando Freire
authors.initials: LF
authors.lastname: Royes
authors.forename: Adriane
authors.initials: A
authors.lastname: Belló-Klein
authors.forename: Jeferson Ferraz
authors.initials: JF
authors.lastname: Goularte
authors.forename: Vera Maria
authors.initials: VM
authors.lastname: Morsch
authors.forename: Margarete Dulce
authors.initials: MD
authors.lastname: Bagatini
authors.forename: Maria Rosa Chitolina
authors.initials: MR
authors.lastname: Schetinger
mesh_terms: D000818:Animals; D001205:Ascorbic Acid / Q000378:metabolism; D015415:Biomarkers / Q000378:metabolism; D001794:Blood Pressure; D001835:Body Weight; D002374:Catalase / Q000097:blood; D006339:Heart Rate; D006973:Hypertension / Q000097:blood / Q000473:pathology* / Q000503:physiopathology; D007668:Kidney / Q000201:enzymology / Q000473:pathology; D015227:Lipid Peroxidation; D008055:Lipids / Q000097:blood; D008297:Male; D019331:NG-Nitroarginine Methyl Ester; D009569:Nitric Oxide / Q000378:metabolism; D010084:Oxidation-Reduction; D018384:Oxidative Stress; D010805:Physical Conditioning, Animal; D050050:Protein Carbonylation; D051381:Rats; D017208:Rats, Wistar; D013438:Sulfhydryl Compounds / Q000097:blood; D013482:Superoxide Dismutase / Q000097:blood; D013550:Swimming; D013599:Systole; D017392:Thiobarbituric Acid Reactive Substances / Q000378:metabolism
chemical_list: D015415:Biomarkers; D008055:Lipids; D013438:Sulfhydryl Compounds; D017392:Thiobarbituric Acid Reactive Substances; D009569:Nitric Oxide; D002374:Catalase; D013482:Superoxide Dismutase; D001205:Ascorbic Acid; D019331:NG-Nitroarginine Methyl Ester