title: Monitoring and control of microbioreactors: an expert opinion on development needs.
abstract: This perspective article is based on an expert panel review on microbioreactor applications in biochemical and biomedical engineering that was organized by the M³C (measurement, monitoring, modelling and control) Working Group of the European Section of Biochemical Engineering Science (ESBES) in the European Federation of Biotechnology (EFB). The aim of the panel was to provide an updated view on the present status of the subject and to identify critical needs and issues for furthering the successful development of microbioreactor monitoring and control. This will benefit future bioprocess development and in vitro toxicity testing. The article concludes with a set of recommendations for extended use and further development of microbioreactors.
authors.affiliation: Technical University of Denmark, Lyngby, Denmark.
authors.forename: Krist V
authors.initials: KV
authors.lastname: Gernaey
authors.forename: Frank
authors.initials: F
authors.lastname: Baganz
authors.forename: Ezequiel
authors.initials: E
authors.lastname: Franco-Lara
authors.forename: Frank
authors.initials: F
authors.lastname: Kensy
authors.forename: Ulrich
authors.initials: U
authors.lastname: Krühne
authors.forename: Marc
authors.initials: M
authors.lastname: Luebberstedt
authors.forename: Uwe
authors.initials: U
authors.lastname: Marx
authors.forename: Eva
authors.initials: E
authors.lastname: Palmqvist
authors.forename: Andreas
authors.initials: A
authors.lastname: Schmid
authors.forename: Frank
authors.initials: F
authors.lastname: Schubert
authors.forename: Carl-Fredrik
authors.initials: CF
authors.lastname: Mandenius
mesh_terms: D000818:Animals; D057005:Bioengineering; D035843:Biomedical Research; D019149:Bioreactors; D001709:Biotechnology; D057166:High-Throughput Screening Assays; D006801:Humans; D046210:Microfluidic Analytical Techniques