title: Comparison of glucose fluctuations between day- and night-time measured using a continuous glucose monitoring system in diabetic dogs.
abstract: Monitoring of blood glucose concentration is important to evaluate the diabetic status of dogs. Continuous glucose monitoring systems (CGMS) have been applied in veterinary medicine for glucose monitoring in diabetic dogs. The purpose of the study was to evaluate the daily glycemic profiles obtained with CGMS and compare glucose fluctuations between day- and night-time in diabetic dogs. Five diabetic dogs were used in this study and were treated with either NPH insulin or insulin detemir. For data analyses, day-time was defined as 9:00 am-9:00 pm and night-time as 9:00 pm-9:00 am. Using glucose profiles, we determined the mean glucose concentrations (1- and 12-hr intervals), and times spent in hyperglycemia >200 mg/dl or hypoglycemia <60 mg/dl. None of the parameters differed significantly between day-time and night-time in dogs treated with NPH insulin or insulin detemir. In conclusion, this study confirmed, using CGMS, that there are no differences in glucose fluctuations between day- and night-time, in diabetic dogs on a similar feeding regimen and insulin administration.
authors.affiliation: Department of Veterinary Nursing & Technology, School of Veterinary Science, Nippon Veterinary and Life Science University, 1-7-1 Kyonancho, Musashino, Tokyo 180-8602, Japan. amori@nvlu.ac.jp
authors.forename: Akihiro
authors.initials: A
authors.lastname: Mori
authors.forename: Miyuki
authors.initials: M
authors.lastname: Kurishima
authors.forename: Hitomi
authors.initials: H
authors.lastname: Oda
authors.forename: Kaori
authors.initials: K
authors.lastname: Saeki
authors.forename: Toshiro
authors.initials: T
authors.lastname: Arai
authors.forename: Toshinori
authors.initials: T
authors.lastname: Sako
mesh_terms: D000818:Animals; D001786:Blood Glucose / Q000378:metabolism* / Q000502:physiology; D002940:Circadian Rhythm / Q000502:physiology*; D003921:Diabetes Mellitus, Experimental / Q000097:blood*; D003922:Diabetes Mellitus, Type 1 / Q000097:blood / Q000662:veterinary*; D004283:Dog Diseases / Q000097:blood*; D004285:Dogs; D005260:Female; D000069057:Insulin Detemir; D007336:Insulin, Isophane; D049528:Insulin, Long-Acting; D008297:Male; D008991:Monitoring, Physiologic / Q000379:methods / Q000662:veterinary*; D013997:Time Factors
chemical_list: D001786:Blood Glucose; D049528:Insulin, Long-Acting; D000069057:Insulin Detemir; D007336:Insulin, Isophane