title: Evidence-based practice: endoscopic skull base resection for malignancy.
abstract: Successful outcomes of endoscopic approaches to benign sinonasal tumors have launched interest in expanding its use for sinonasal malignancy. Because of the heterogeneity and rarity of sinonasal malignancy, evidence for clinical outcomes of endoscopic approaches versus traditional craniofacial resection is low. Using the Oxford Center for Evidence-based Medicine guidelines, we present the existing evidence comparing both techniques for a variety of sinonasal malignancies.
authors.affiliation: Department of Otolaryngology-Head and Neck Surgery, University of North Carolina at Chapel Hill, 170 Manning Drive, CB 7070, Chapel Hill, NC 27599-7070, USA.
authors.forename: Rounak B
authors.initials: RB
authors.lastname: Rawal
authors.forename: Mitchell R
authors.initials: MR
authors.lastname: Gore
authors.forename: Richard J
authors.initials: RJ
authors.lastname: Harvey
authors.forename: Adam M
authors.initials: AM
authors.lastname: Zanation
mesh_terms: D000230:Adenocarcinoma / Q000473:pathology*; D002648:Child; D004210:Dissection / Q000009:adverse effects / Q000379:methods / Q000706:statistics & numerical data; D004724:Endoscopy / Q000009:adverse effects / Q000379:methods / Q000706:statistics & numerical data; D018304:Esthesioneuroblastoma, Olfactory / Q000473:pathology*; D055317:Evidence-Based Practice; D006801:Humans; D015994:Incidence; D008545:Melanoma / Q000473:pathology*; D008875:Middle Aged; D060787:Neoplasm Grading; D009367:Neoplasm Staging; D009669:Nose Neoplasms / Q000145:classification / Q000453:epidemiology / Q000473:pathology / Q000601:surgery*; D017063:Outcome Assessment, Health Care; D010255:Paranasal Sinus Neoplasms / Q000145:classification / Q000453:epidemiology / Q000473:pathology / Q000601:surgery*; D012307:Risk Factors; D019291:Skull Base / Q000473:pathology / Q000601:surgery; D015996:Survival Rate; D016896:Treatment Outcome