title: Risk estimation of metabolic syndrome at one and three years after a pregnancy complicated by preeclampsia.
abstract: BACKGROUND
  Our goal was to determine the prevalence of metabolic syndrome in women following a pregnancy complicated by preeclampsia and to determine whether this changes between one- and three-years postpartum.
  
  
  METHODS
  We recruited women into a longitudinal prospective  cohort following a pregnancy with or without preeclampsia.  The prevalence of cardiometabolic factors were assessed at  one- and three-years postpartum. A total of 217 women completed a visit at one year postpartum (n = 99 preeclampsia, n = 118 control subjects) and 120 completed a visit at three-years  (n = 73 preeclampsia, n = 47 control subjects).
  
  
  RESULTS
  The prevalence of metabolic syndrome at one- and three-years postpartum was significantly greater in women who had preeclampsia (18.18% at one year, 21.92% at three-years) than in control subjects (6.78%, 6.38%) (P < 0.05), but did not change over time.
  
  
  CONCLUSIONS
  Given the difficulty in following women long-term, either clinically or as part of study, and because cardiometabolic factors do not change significantly between one- and three-years postpartum, strategies for health preservation and disease prevention should be adopted in the first-year postpartum.
authors.affiliation: Department of Obstetrics and Gynaecology, Kingston General Hospital, Queen's University, Kingston ON; Department of Biomedical and Molecular Sciences, Kingston General Hospital, Queen's University, Kingston ON.
authors.forename: Graeme N
authors.initials: GN
authors.lastname: Smith
authors.affiliation: Department of Obstetrics and Gynaecology, Kingston General Hospital, Queen's University, Kingston ON; Department of Biomedical and Molecular Sciences, Kingston General Hospital, Queen's University, Kingston ON.
authors.forename: Jessica
authors.initials: J
authors.lastname: Pudwell
authors.affiliation: Department of Obstetrics and Gynecology, Ottawa Health Research Institute, University of Ottawa, Ottawa ON.
authors.forename: Mark
authors.initials: M
authors.lastname: Walker
authors.affiliation: Department of Obstetrics and Gynecology, Ottawa Health Research Institute, University of Ottawa, Ottawa ON.
authors.forename: Shi-Wu
authors.initials: SW
authors.lastname: Wen
mesh_terms: D000328:Adult; D029681:Arabidopsis Proteins; D001786:Blood Glucose / Q000032:analysis; D001794:Blood Pressure; D015992:Body Mass Index; D005215:Fasting; D005260:Female; D006801:Humans; D008137:Longitudinal Studies; D024821:Metabolic Syndrome / Q000453:epidemiology* / Q000209:etiology / Q000517:prevention & control; D009687:Nuclear Proteins; D049590:Postpartum Period; D011225:Pre-Eclampsia / Q000503:physiopathology*; D011247:Pregnancy; D011446:Prospective Studies; D012307:Risk Factors
chemical_list: D029681:Arabidopsis Proteins; D001786:Blood Glucose; D009687:Nuclear Proteins; C523534:TIC protein, Arabidopsis