title: Risk factors for peristomal pyoderma gangrenosum complicating inflammatory bowel disease.
abstract: OBJECTIVE
  Risk factors for peristomal pyoderma gangrenosum (PPG) are not well defined. The aim of this study was to evaluate risk factors associated with development of PPG.
  
  
  METHODS
  Both PPG patients and controls were obtained by searching a database of the Cleveland Clinic using the ICD-9 code from March 2005 to May 2011. The control group was selected by matching for underlying diseases and type of stoma in a ratio of 3:1. Univariate and multivariate analyses were performed.
  
  
  RESULTS
  A total of 15 PPG cases and 45 controls were included. The mean age at the time of PPG diagnosis was 46.0 ± 14.4 years. The underlying disease was Crohn's disease in 7 patients (46.7%), ulcerative colitis in 7 (46.7%) and indeterminate colitis in 1 (6.7%). Eleven patients (73.3%) had end ileostomy, 3 (20.0%) had loop ileostomy and 1 (6.7%) had colostomy. Eleven patients (73.3%) had active intestinal disease. In multivariate analysis, female gender, the presence of concurrent autoimmune disorders, and a high body mass index (BMI) were significantly associated with the presence of PPG, with odds ratios of 8.385 (95% confidence interval [CI]: 1.496-46.982, p=0.015), 6.882 (95% CI:1.438-32.941, p=0.016), and 9.895 (95% CI: 1.970-43.704, p=0.005), respectively. After a median follow-up of 12.8 (interquartile range: 7.9-20.1) months with appropriate therapy, PPG healed in 8 patients (53.3%) and improved in 7 (46.7%) patients, after treatment.
  
  
  CONCLUSIONS
  Female gender, the presence of autoimmune disorders and a high BMI appeared to be associated with an increased risk for the development of PPG in IBD patients.
authors.affiliation: Department of Colorectal Surgery, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA.
authors.forename: Xian-rui
authors.initials: XR
authors.lastname: Wu
authors.forename: Saurabh
authors.initials: S
authors.lastname: Mukewar
authors.forename: Ravi P
authors.initials: RP
authors.lastname: Kiran
authors.forename: Feza H
authors.initials: FH
authors.lastname: Remzi
authors.forename: Jeffery
authors.initials: J
authors.lastname: Hammel
authors.forename: Bo
authors.initials: B
authors.lastname: Shen
mesh_terms: D000328:Adult; D001327:Autoimmune Diseases / Q000150:complications; D015992:Body Mass Index; D016022:Case-Control Studies; D003093:Colitis, Ulcerative / Q000150:complications* / Q000601:surgery; D003125:Colostomy / Q000009:adverse effects; D003424:Crohn Disease / Q000150:complications* / Q000601:surgery; D005260:Female; D006801:Humans; D007081:Ileostomy / Q000009:adverse effects; D008297:Male; D008875:Middle Aged; D017511:Pyoderma Gangrenosum / Q000150:complications* / Q000628:therapy; D012307:Risk Factors; D012737:Sex Factors