title: Identifying cancer highly-expressed membrane receptors for targeted drug delivery.
abstract: Currently, the accompanying side effects of anti-cancer drugs owing to incorrect delivery to normal tissues should be reduced. We present a database (MRTDD) with identified cancer highly-expressed membrane receptors (CHMRs) which can be used in targeted drug delivery. To evaluate the probability of occurrence of incorrect delivery, we calculate tissue index for each CHMR and expect to identify good candidates. The information provided includes: (1) genomic annotations; (2) gene expression profiles of membrane receptors in cancer tissue vs. corresponding normal tissue, normal tissues of body and cancer cell-lines; (3) available antibody services of manufacturers. MRTDD is available at http://mrtdd.mbc.nctu.edu.tw/.
authors.affiliation: Institute of Bioinformatics and Systems Biology, National Chiao Tung University, Hsin-Chu, Taiwan. loveariddle.bi96g@g2.nctu.edu.tw
authors.forename: Wei-Chih
authors.initials: WC
authors.lastname: Huang
authors.forename: Feng-Mao
authors.initials: FM
authors.lastname: Lin
authors.forename: Tzu-Hao
authors.initials: TH
authors.lastname: Chang
authors.forename: Kuang-Wen
authors.initials: KW
authors.lastname: Liao
authors.forename: Hsien-Da
authors.initials: HD
authors.lastname: Huang
mesh_terms: D000906:Antibodies / Q000627:therapeutic use; D000970:Antineoplastic Agents / Q000627:therapeutic use; D030562:Databases, Protein; D016503:Drug Delivery Systems; D023281:Genomics; D006801:Humans; D009369:Neoplasms / Q000188:drug therapy*; D018160:Receptors, Cytoplasmic and Nuclear / Q000737:chemistry* / Q000378:metabolism
chemical_list: D000906:Antibodies; D000970:Antineoplastic Agents; D018160:Receptors, Cytoplasmic and Nuclear