title: A magnetic cell-based sensor.
abstract: Cell-based sensing represents a new paradigm for performing direct and accurate detection of cell- or tissue-specific responses by incorporating living cells or tissues as an integral part of a sensor. Here we report a new magnetic cell-based sensing platform by combining magnetic sensors implemented in the complementary metal-oxide-semiconductor (CMOS) integrated microelectronics process with cardiac progenitor cells that are differentiated directly on-chip. We show that the pulsatile movements of on-chip cardiac progenitor cells can be monitored in a real-time manner. Our work provides a new low-cost approach to enable high-throughput screening systems as used in drug development and hand-held devices for point-of-care (PoC) biomedical diagnostic applications.
authors.affiliation: Department of Electrical Engineering, California Institute of Technology, Pasadena, CA 91125, USA.
authors.forename: Hua
authors.initials: H
authors.lastname: Wang
authors.forename: Alborz
authors.initials: A
authors.lastname: Mahdavi
authors.forename: David A
authors.initials: DA
authors.lastname: Tirrell
authors.forename: Ali
authors.initials: A
authors.lastname: Hajimiri
mesh_terms: D000818:Animals; D002454:Cell Differentiation; D053595:Embryonic Stem Cells / Q000166:cytology*; D057166:High-Throughput Screening Assays; D008280:Magnetics / Q000295:instrumentation / Q000379:methods*; D051379:Mice; D012666:Semiconductors