title: Curative effect of Terminalia chebula extract on acetic acid-induced experimental colitis: role of antioxidants, free radicals and acute inflammatory marker.
abstract: The present study has evaluated the healing effects of extract of dried fruit pulp of Terminalia chebula (TCE) on acetic acid (AA)-induced colitis in rats. TCE (600 mg/kg) showed healing effects against AA-induced colonic damage score and weight when administered orally daily for 14 days. TCE was further studied for its effects on various physical (mucus/blood in stool and stool frequency, food and water intake and body weight changes), histology, antibacterial activity and free radicals (NO and LPO), antioxidants (SOD, CAT and GSH) and myeloperoxidase in colonic tissue. Intra-colonic AA administration increased colonic mucosal damage and inflammation, mucus/bloody diarrhoea, stool frequency, but decreased body weight which were reversed by TCE and sulfasalazine (SS, positive control) treatments. TCE showed antibacterial activity and both TCE and SS enhanced the antioxidants, but decreased free radicals and myeloperoxidase activities affected in acetic acid-induced colitis. TCE indicated the presence of active principles with proven antioxidants, anti-inflammatory, immunomodulatory, and free radical scavenging and healing properties. Thus, TCE seemed to be safe and effective in healing experimental colitis.
authors.affiliation: Department of Pharmacology, Institute of Medical Sciences, Banaras Hindu University, Varanasi, 221005, India.
authors.forename: M K
authors.initials: MK
authors.lastname: Gautam
authors.forename: Shalini
authors.initials: S
authors.lastname: Goel
authors.forename: R R
authors.initials: RR
authors.lastname: Ghatule
authors.forename: A
authors.initials: A
authors.lastname: Singh
authors.forename: G
authors.initials: G
authors.lastname: Nath
authors.forename: R K
authors.initials: RK
authors.lastname: Goel
mesh_terms: D019342:Acetic Acid / Q000494:pharmacology; D000818:Animals; D000897:Anti-Ulcer Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D000975:Antioxidants / Q000378:metabolism*; D015415:Biomarkers / Q000378:metabolism; D003093:Colitis, Ulcerative / Q000139:chemically induced / Q000188:drug therapy* / Q000276:immunology / Q000473:pathology; D004195:Disease Models, Animal; D005260:Female; D005609:Free Radicals / Q000378:metabolism*; D005638:Fruit / Q000737:chemistry; D007413:Intestinal Mucosa / Q000187:drug effects / Q000276:immunology / Q000382:microbiology / Q000473:pathology; D008297:Male; D051379:Mice; D010936:Plant Extracts / Q000008:administration & dosage / Q000627:therapeutic use*; D051381:Rats; D011919:Rats, Inbred Strains; D029766:Terminalia / Q000737:chemistry*
chemical_list: D000897:Anti-Ulcer Agents; D000975:Antioxidants; D015415:Biomarkers; D005609:Free Radicals; D010936:Plant Extracts; D019342:Acetic Acid