title: RNAi-based nanomedicines for targeted personalized therapy.
abstract: RNA interference (RNAi) has just made it through the pipeline to clinical trials. However, in order for RNAi to serve as an ideal personalized therapeutics and be clinically approved-safe, specific, and potent strategies must be devised for efficient delivery of RNAi payloads to specific cell types, which despite the immense potential, remains a challenge. Through evaluating the recent reported studies in this field, we introduce the progress in designing targeted nano-scaled strategies that are anticipated to overcome the delivery drawbacks and along with the exciting "omics" discipline to personalize RNAi-based therapeutics.
authors.affiliation: Laboratory of Nanomedicine, Department of Cell Research and Immunology, George S. Wise Faculty of Life Science, Israel.
authors.forename: Ala
authors.initials: A
authors.lastname: Daka
authors.forename: Dan
authors.initials: D
authors.lastname: Peer
mesh_terms: D000818:Animals; D006801:Humans; D050997:Nanomedicine; D053758:Nanoparticles / Q000008:administration & dosage; D057285:Precision Medicine; D034622:RNA Interference; D034741:RNA, Small Interfering / Q000008:administration & dosage
chemical_list: D034741:RNA, Small Interfering