title: Comprehensive synthesis of photoreactive (3-trifluoromethyl)diazirinyl indole derivatives from 5- and 6- trifluoroacetylindoles for photoaffinity labeling.
abstract: 5- and 6-trifluoromethyldiazirinyl indoles were synthesized from corresponding bromoindole derivatives for the first time. They acted as mother skeletons for the comprehensive synthesis of various bioactive indole metabolites. These can be used in biological functional analysis as diazirine-based photoaffinity labels.
authors.affiliation: Graduate School of Agriculture, Hokkaido University, Kita 9, Nishi 9, Kita-ku, Sapporo 060-8589, Japan.
authors.forename: Yuta
authors.initials: Y
authors.lastname: Murai
authors.forename: Katsuyoshi
authors.initials: K
authors.lastname: Masuda
authors.forename: Yasuko
authors.initials: Y
authors.lastname: Sakihama
authors.forename: Yasuyuki
authors.initials: Y
authors.lastname: Hashidoko
authors.forename: Yasumaru
authors.initials: Y
authors.lastname: Hatanaka
authors.forename: Makoto
authors.initials: M
authors.lastname: Hashimoto
mesh_terms: D003978:Diazomethane / Q000031:analogs & derivatives* / Q000737:chemistry* / Q000378:metabolism; D006845:Hydrocarbons, Fluorinated / Q000138:chemical synthesis* / Q000737:chemistry; D007211:Indoles / Q000138:chemical synthesis* / Q000737:chemistry*; D015394:Molecular Structure; D019920:Photoaffinity Labels / Q000138:chemical synthesis* / Q000737:chemistry / Q000378:metabolism; D010777:Photochemistry
chemical_list: C578505:(3-trifluoromethyl)diazirinyl indole; D006845:Hydrocarbons, Fluorinated; D007211:Indoles; D019920:Photoaffinity Labels; D003978:Diazomethane