title: Strategies for p53 reactivation in human sarcoma.
abstract: Emerging strategies in cancer therapeutics link the genomic mutational and proteomic landscape, allowing intelligent reasoning on target selection. In this issue of Cancer Cell, Piccinin and colleagues use this approach to demonstrate that the mesenchymal protein Twist1 inhibits p53, providing a novel target for reactivation of p53 in human sarcoma.
authors.affiliation: Institute of Genetics and Molecular Medicine, University of Edinburgh, UK. ted.hupp@ed.ac.uk
authors.forename: Ted R
authors.initials: TR
authors.lastname: Hupp
authors.forename: Richard L
authors.initials: RL
authors.lastname: Hayward
authors.forename: Borek
authors.initials: B
authors.lastname: Vojtesek