title: Transfemoral versus conventional aortic valve implantation--early postoperative cognitive outcome.
abstract: OBJECTIVE
  Reduction of cognitive function is a possible side effect after cardiac surgery. We investigated the effect of transfemoral versus conventional aortic valve replacement on cognitive performance early after surgery.
  
  
  METHODS
  50 patients with transfemoral, catheter-based aortic valve implantations were compared to 50 patients with conventional surgical aortic valve replacement. Six neuropsychological subtests from the Syndrom Kurz Test and Alzheimer's Disease Assessment Scale were performed preoperatively and on the third postoperative day in a double blind fashion. To assess the overall cognitive function and the degree of cognitive change across all tests after surgery we combined the six test-scores by principal component analysis.
  
  
  RESULTS
  The preoperative (Spre), as well as postoperative (Spost) overall cognitive function scores, were not significantly different between the groups and showed deterioration within both groups (Spre conv. 0.2 ± 1.0 vs Spost conv. -0.6 ± 1.1, p <0.0005 and Spre transfem. -0.2 ± 1.0 vs Spost transfem. -0.6 ± 1.1, p = 0.002). This decline (Spre -Spost) was not associated with the type of operation (p = 0.1).
  
  
  CONCLUSIONS
  Transfemoral aortic valve implantation has no cerebroprotective advantage since it leads also to an early postoperative decline of neuropsychological abilities, which is comparable to conventional aortic valve replacement.
authors.affiliation: Department of Cardiovascular Surgery of Charité Hospital, Medical University, Berlin, Germany. sebastian.holinski@charite.de
authors.forename: Sebastian
authors.initials: S
authors.lastname: Holinski
authors.forename: Paul
authors.initials: P
authors.lastname: Staebe
authors.forename: Torsten
authors.initials: T
authors.lastname: Geyer
authors.forename: Konrad
authors.initials: K
authors.lastname: Neumann
authors.forename: Ralf
authors.initials: R
authors.lastname: Uebelhack
authors.forename: Wolfgang
authors.initials: W
authors.lastname: Konertz
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001021:Aortic Valve / Q000601:surgery*; D001288:Attention; D006328:Cardiac Catheterization / Q000009:adverse effects / Q000379:methods*; D016009:Chi-Square Distribution; D003071:Cognition; D003072:Cognition Disorders / Q000175:diagnosis / Q000209:etiology* / Q000523:psychology; D004311:Double-Blind Method; D005260:Female; D005263:Femoral Artery; D019918:Heart Valve Prosthesis Implantation / Q000009:adverse effects / Q000379:methods*; D006801:Humans; D016014:Linear Models; D016015:Logistic Models; D008297:Male; D011939:Mental Recall; D008875:Middle Aged; D009483:Neuropsychological Tests; D025341:Principal Component Analysis; D013997:Time Factors; D016896:Treatment Outcome