title: Inhibited PTHLH downstream leukocyte adhesion-mediated protein amino acid N-linked glycosylation coupling Notch and JAK-STAT cascade to iron-sulfur cluster assembly-induced aging network in no-tumor hepatitis/cirrhotic tissues (HBV or HCV infection) by systems-theoretical analysis.
abstract: We analyzed the different biological processes and occurrence numbers between low expression inhibited PTHLH downstream-mediated aging gene ontology (GO) network of no-tumor hepatitis/cirrhotic tissues (HBV or HCV infection) and the corresponding high expression (fold change ≥2) inhibited GO network of human hepatocellular carcinoma (HCC). Inhibited PTHLH downstream-mediated aging network consisted of aging, branched chain family amino acid biosynthesis, cellular metabolism, cholesterol biosynthesis, coupled to cyclic nucleotide second messenger, cytolysis, 'de novo' GDP-l-fucose biosynthesis, detection of mechanical stimulus, glucose homeostasis, G-protein signaling, leukocyte adhesion, iron-sulfur cluster assembly, JAK-STAT cascade, Notch signaling pathway, nucleotide-sugar metabolism, peptidyl-tyrosine sulfation, protein amino acid N-linked glycosylation, protein amino acid phosphorylation, response to drug, rRNA processing, translational initiation, ubiquitin-dependent protein catabolism, homophilic cell adhesion in no-tumor hepatitis/cirrhotic tissues. We proposed inhibited PTHLH downstream leukocyte adhesion-mediated protein amino acid N-linked glycosylation coupling Notch and JAK-STAT cascade to iron-sulfur cluster assembly-induced aging network. Our hypothesis was verified by the same inhibited PTHLH downstream-mediated aging GO network in no-tumor hepatitis/cirrhotic tissues with the corresponding activated GO network of HCC, or the different with the corresponding activated GO network of no-tumor hepatitis/cirrhotic tissues. Inhibited PTHLH downstream leukocyte adhesion-mediated protein amino acid N-linked glycosylation coupling Notch and JAK-STAT cascade to iron-sulfur cluster assembly-induced aging network included TSTA3, ALK, CIAO1, NOTCH3 in no-tumor hepatitis/cirrhotic tissues from the GEO data set using gene regulatory network inference method and our programming.
authors.affiliation: Biomedical Center, School of Electronic Engineering, Beijing University of Posts and Telecommunications, Beijing, 100876, China. wanglin98@tsinghua.org.cn
authors.forename: Lin
authors.initials: L
authors.lastname: Wang
authors.forename: Juxiang
authors.initials: J
authors.lastname: Huang
authors.forename: Minghu
authors.initials: M
authors.lastname: Jiang
authors.forename: Hong
authors.initials: H
authors.lastname: Lin
authors.forename: Lianxiu
authors.initials: L
authors.lastname: Qi
authors.forename: Haizhen
authors.initials: H
authors.lastname: Diao
mesh_terms: D000375:Aging; D005355:Fibrosis / Q000378:metabolism*; D015972:Gene Expression Regulation, Neoplastic; D006031:Glycosylation; D016174:Hepacivirus / Q000378:metabolism; D006505:Hepatitis / Q000378:metabolism*; D006515:Hepatitis B virus / Q000378:metabolism; D006706:Homeostasis; D006801:Humans; D007506:Iron-Sulfur Proteins / Q000737:chemistry*; D007962:Leukocytes / Q000166:cytology*; D008954:Models, Biological; D009369:Neoplasms / Q000378:metabolism; D020411:Oligonucleotide Array Sequence Analysis; D044162:Parathyroid Hormone-Related Protein / Q000378:metabolism*; D010766:Phosphorylation; D051880:Receptors, Notch / Q000378:metabolism*; D015398:Signal Transduction; D013598:Systems Theory
chemical_list: D007506:Iron-Sulfur Proteins; C470121:PTHLH protein, human; D044162:Parathyroid Hormone-Related Protein; D051880:Receptors, Notch