title: An efficient one-pot synthesis and photoinduced DNA cleavage studies of 2-chloro-3-(5-aryl-4,5-dihydroisoxazol-3-yl)quinolines.
abstract: 4,5-Dihydroisoxazoles continue to attract considerable interest due to their wide spread biological activities. Here, we identify an efficient protocol for the preparation of 4,5-dihydroisoxazoles (2-isaxazolines) (4a-g) from quinolinyl chalcones. The nucleolytic activities of synthesized compounds were investigated by agarose gel electrophoresis. All these compounds were showed the remarkable DNA cleavage activity (concentration dependent) with pUC19 DNA at 365nm UV light. The DNA cleavage activity was significantly enhanced by the presence of iminyl and carboxy radicals of DIQ.
authors.affiliation: Department of Studies and Research in Chemistry, Kuvempu University, Shankaraghatt 577 451, India. bindu12_naik@rediffmail.com
authors.forename: P J
authors.initials: PJ
authors.lastname: Bindu
authors.forename: K M
authors.initials: KM
authors.lastname: Mahadevan
authors.forename: T R
authors.initials: TR
authors.lastname: Ravikumar Naik
mesh_terms: D053837:DNA Cleavage / Q000187:drug effects* / Q000528:radiation effects*; D007555:Isoxazoles / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D055668:Photochemical Processes; D017319:Photosensitizing Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology* / Q000528:radiation effects; D010957:Plasmids / Q000187:drug effects / Q000528:radiation effects; D011804:Quinolines / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology* / Q000528:radiation effects; D013329:Structure-Activity Relationship; D014466:Ultraviolet Rays
chemical_list: D007555:Isoxazoles; D017319:Photosensitizing Agents; D011804:Quinolines