title: Modulation of drug release from nanocarriers loaded with a poorly water soluble drug (flurbiprofen) comprising natural waxes.
abstract: In this study, flurbiprofen (FLB) Solid Lipid Nanoparticles (SLN) composed from a mixture of beeswax and carnauba wax, Tween 80 and egg lecithin as emulsifiers have been prepared. FLB was incorporated as model lipophilic drug to assess the influence of matrix composition in the drug release profile. SLN were produced by microemulsion technique. In vitro studies were performed in Phosphate Buffered Saline (PBS). The FLB loaded SLN showed a mean particle size of 75 +/- 4 nm, a polydispersity index approximately 0.2 +/- 0.02 and an entrapment efficiency (EE) of more than 95%. Suspensions were stable, with zeta potential values in the range of -15 to -17 mV. DSC thermograms and UV analysis indicated the stability of nanoparticles with negligible drug leakage. Nanoparticles with higher beeswax content in their core exhibited faster drug release than those containing more carnauba wax.
authors.affiliation: Institute of Pharmaceutical Education, Boradi, Tal-Shirpur, Dist-Dhule, India. baviskar@sancharnet.in
authors.forename: D T
authors.initials: DT
authors.lastname: Baviskar
authors.forename: A S
authors.initials: AS
authors.lastname: Amritkar
authors.forename: H S
authors.initials: HS
authors.lastname: Chaudhari
authors.forename: D K
authors.initials: DK
authors.lastname: Jain
mesh_terms: D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage* / Q000737:chemistry*; D002152:Calorimetry, Differential Scanning; D003692:Delayed-Action Preparations; D004337:Drug Carriers; D005079:Excipients; D005480:Flurbiprofen / Q000008:administration & dosage* / Q000737:chemistry*; D007700:Kinetics; D053758:Nanoparticles; D010316:Particle Size; D011136:Polysorbates; D012995:Solubility; D013501:Surface-Active Agents; D014885:Waxes / Q000737:chemistry*
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D003692:Delayed-Action Preparations; D004337:Drug Carriers; D005079:Excipients; D011136:Polysorbates; D013501:Surface-Active Agents; D014885:Waxes; C038228:beeswax; D005480:Flurbiprofen; C026344:carnauba wax