title: C677T Methylenetetrahydrofolate Reductase (MTHFR) Gene Polymorphism in Schizophrenia and Bipolar Disorder: An Association Study in Iranian Population.
abstract: OBJECTIVE
  The methylenetetrahydrofolate reductase (MTHFR) gene polymorphism C677T is suspected to be a risk factor for psychiatric disorders, but it remains inconclusive whether the MTHFR polymorphism C677T is imputed to vulnerability to schizophrenia and bipolar disorder.
  
  
  METHODS
  We prompted impetus to appraise this polymorphism in an Iranian population. Therefore, 90 patients with bipolar disorder type I (BID), 66 patients with schizophrenia diagnosed according to DSM-IV criteria, and 94 unrelated controls with no history of psychiatric disorders were recruited for this study. Genotype distribution and allelic frequencies of C677T polymorphism were investigated.
  
  
  RESULTS
  We found no robust differences between patients with BID and schizophrenia with control participants either for allele frequencies or genotype distribution of MTHFR C677T polymorphism. However, a trend toward an increased risk for T allele was observed in the BID patients [with odds ratio (OR) of 1.28(CI 95%: 0.8-1.31), p>0.05].
  
  
  CONCLUSIONS
  However, the present and some previous studies failed to elucidate possible interaction between MTHFR C677T polymorphism and vulnerability to schizophrenia and bipolar disorder; still some associations have been revealed in performed meta-analyses that warrant further studies.
authors.affiliation: Psychosomatic Research Group, Endocrinology and Metabolism Research Center, Tehran University of Medical Sciences, Tehran, Iran.
authors.forename: Seyed Masoud
authors.initials: SM
authors.lastname: Arzaghi
authors.forename: Arash
authors.initials: A
authors.lastname: Hossein-Nezhad
authors.forename: Seyed Vahid
authors.initials: SV
authors.lastname: Shariat
authors.forename: Alireza
authors.initials: A
authors.lastname: Ghodsipour
authors.forename: Jamal
authors.initials: J
authors.lastname: Shams
authors.forename: Bagher
authors.initials: B
authors.lastname: Larijani