title: One-pot synthesis of amides from aldehydes and amines via C-H bond activation.
abstract: A one-pot synthesis of amides from aldheydes with N-chloroamines, prepared in situ from amines, has been developed. Both aliphatic and aromatic aldehydes and many types of mono- and disubstituted amines are tolerant in this transformation. This cross-coupling reaction appears simple and convenient, has a wide substrate scope and makes use of cheap, abundant, and easily available reagents.
authors.affiliation: Dipartimento di Chimica e Farmacia, Università degli Studi di Sassari, Via Vienna 2, I-07100 Sassari, Italy.
authors.forename: Roberta
authors.initials: R
authors.lastname: Cadoni
authors.forename: Andrea
authors.initials: A
authors.lastname: Porcheddu
authors.forename: Giampaolo
authors.initials: G
authors.lastname: Giacomelli
authors.forename: Lidia
authors.initials: L
authors.lastname: De Luca
mesh_terms: D000447:Aldehydes / Q000737:chemistry*; D000577:Amides / Q000138:chemical synthesis*; D000588:Amines / Q000737:chemistry*; D002244:Carbon / Q000737:chemistry; D005609:Free Radicals / Q000737:chemistry; D006859:Hydrogen / Q000737:chemistry; D015394:Molecular Structure; D010084:Oxidation-Reduction
chemical_list: D000447:Aldehydes; D000577:Amides; D000588:Amines; D005609:Free Radicals; D002244:Carbon; D006859:Hydrogen