title: Serum antibodies to 25 myelin oligodendrocyte glycoprotein epitopes in multiple sclerosis and neuromyelitis optica: clinical value for diagnosis and disease activity.
abstract: BACKGROUND
  Whether antibody to myelin oligodendrocyte glycoprotein (MOG) can be a diagnostic marker for multiple sclerosis (MS) is still controversial. Recent studies suggested that serum specific anti-MOG epitope antibody might be an MS specific marker. However, these studies did not include neuromyelitis optica (NMO) which might be proven to also have anti-MOG antibody. Hence, the present study was undertaken to investigate the clinical value of serum antibodies to 25 MOG epitopes in conventional MS (CMS) and NMO.
  
  
  METHODS
  Serum anti-MOG epitope IgG was detected in 61 CMS patients, 54 NMO patients, and 77 healthy controls, using enzyme-linked immunosorbent assay (ELISA).
  
  
  RESULTS
  Anti-MOG(27-38) IgG levels in both CMS and NMO patients were significantly higher than that in healthy controls (optical density (OD): 0.64 ± 0.38, 0.48 ± 0.23 vs. 0.19 ± 0.09; P = 0.000). CMS and NMO patients in relapse stage had significantly higher anti-MOG(27-38) IgG level than patients in remission stage (OD: 0.55 ± 0.14 vs. 0.24 ± 0.09, P = 0.027).
  
  
  CONCLUSIONS
  Although serum anti-MOG epitope IgG could not differentiate MS from NMO, it may be a useful marker for monitoring disease activity.
authors.affiliation: Department of Neurology, Peking Union Medical College Hospital, Beijing, China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Xu
authors.forename: Yao
authors.initials: Y
authors.lastname: Zhang
authors.forename: Cai-yan
authors.initials: CY
authors.lastname: Liu
authors.forename: Bin
authors.initials: B
authors.lastname: Peng
authors.forename: Jian-ming
authors.initials: JM
authors.lastname: Wang
authors.forename: Xiao-jun
authors.initials: XJ
authors.lastname: Zhang
authors.forename: Hai-feng
authors.initials: HF
authors.lastname: Li
authors.forename: Li-ying
authors.initials: LY
authors.lastname: Cui
mesh_terms: D000328:Adult; D000906:Antibodies / Q000097:blood* / Q000276:immunology*; D000939:Epitopes / Q000276:immunology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000097:blood* / Q000276:immunology*; D063308:Myelin-Oligodendrocyte Glycoprotein / Q000276:immunology*; D009471:Neuromyelitis Optica / Q000097:blood* / Q000276:immunology*
chemical_list: D000906:Antibodies; D000939:Epitopes; D063308:Myelin-Oligodendrocyte Glycoprotein