title: [Prospective study of the association between fasting glucose concentrations and liver cirrhosis risk].
abstract: OBJECTIVE
  To investigate the association between concentration levels of fasting serum glucose and liver cirrhosis.
  
  
  METHODS
  A nested case-control study was carried out based on the sample cohort from the Nutrition Intervention Trials previously conducted in one country in Henan province. Using an automatic biochemical analysis system and enzyme-linked immunoassay, baseline serum samples from 310 liver cirrhosis patients and 620 healthy controls were tested for fasting glucose concentration, hepatitis B surface antigen (HBsAg), hepatitis B core antibody (anti-HBc), and hepatitis C virus antibody (anti-HCV). Baseline demographic information was collected by questionnaire. The serum glucose values were divided into quintiles and applied to a logistic regression model to estimate odds ratios (ORs) and 95% confidence intervals (95% CIs).
  
  
  RESULTS
  The mean fasting blood glucose level was significantly higher in cases (4.5+/-1.8 mmol/L) than in controls (4.2+/-2.1 mmol/L) (t=-2.414, P=0.016). The individuals in the highest quintile had a significantly higher risk of disease than those in the lowest quintile [OR=1.672 (1.080, 2.588)]. Moreover, increase in glucose level was accompanied by increased risk, and the relation showed statistically significant linearity (P=0.002). The statistical significance of risk remained after adjustment for potential confounders, including sex, age, HBsAg, anti-HBc, and residence running water status [OR=1.96 (1.216, 3.157), P=0.001].
  
  
  CONCLUSIONS
  Elevated serum fasting glucose concentration was an independent risk factor of cirrhosis.
authors.affiliation: School of Public Health and Administration, Chongqing Medical University, Chongqing, China.
authors.forename: Liang-yu
authors.initials: LY
authors.lastname: Yin
authors.forename: Wen
authors.initials: W
authors.lastname: Chen
authors.forename: Jian-feng
authors.initials: JF
authors.lastname: Cui
authors.forename: Bin
authors.initials: B
authors.lastname: Liu
authors.forename: Jiang
authors.initials: J
authors.lastname: Yin
authors.forename: Jin-hu
authors.initials: JH
authors.lastname: Fan
authors.forename: Feng
authors.initials: F
authors.lastname: Chen
authors.forename: Xin-fu
authors.initials: XF
authors.lastname: Liu
authors.forename: Chun-jing
authors.initials: CJ
authors.lastname: Fu
authors.forename: Xing-bi
authors.initials: XB
authors.lastname: Dai
mesh_terms: D000328:Adult; D001786:Blood Glucose / Q000378:metabolism*; D016022:Case-Control Studies; D002681:China / Q000453:epidemiology; D005260:Female; D006801:Humans; D008103:Liver Cirrhosis / Q000097:blood* / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D012307:Risk Factors
chemical_list: D001786:Blood Glucose