title: Changes in the serotypes of Hungarian pneumococci isolated mainly from invasive infections: a review of all available data between 1988 and 2011.
abstract: Streptococcus pneumoniae is responsible for a high level of morbidity and mortality, especially among children. For a long time, only the polysaccharide vaccine was available against pneumococcal infections, but in the last decade special conjugate vaccines were developed for paediatric use. These vaccines have made a deep impact on serotype distribution all over the world, by suppressing those serotypes included in the vaccines, while new, previously rare types emerged. These changes have been monitored closely in numerous publications all over the world. Nevertheless, data on pneumococcal serotypes in Hungary were mostly published in Hungarian, therefore not available in the international literature. In this meta-analysis, our aim was to collect and summarise all available data, and try to follow the changes observed after the introduction of the conjugate vaccines.
authors.affiliation: Semmelweis University, Institute of Medical Microbiology, Budapest, Hungary.
authors.forename: Adrienn
authors.initials: A
authors.lastname: Tóthpál
authors.forename: Krisztina
authors.initials: K
authors.lastname: Laub
authors.forename: Szilvia
authors.initials: S
authors.lastname: Kardos
authors.forename: Károly
authors.initials: K
authors.lastname: Nagy
authors.forename: Orsolya
authors.initials: O
authors.lastname: Dobay
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D006814:Hungary / Q000453:epidemiology; D007223:Infant; D008297:Male; D008875:Middle Aged; D011008:Pneumococcal Infections / Q000453:epidemiology / Q000382:microbiology* / Q000517:prevention & control; D022242:Pneumococcal Vaccines / Q000008:administration & dosage / Q000235:genetics; D012703:Serotyping; D013296:Streptococcus pneumoniae / Q000145:classification* / Q000235:genetics / Q000302:isolation & purification*; D055815:Young Adult
chemical_list: D022242:Pneumococcal Vaccines