title: Urinary chiro- and myo-inositol levels as a biological marker for type 2 diabetes mellitus.
abstract: BACKGROUND
  The aim of this study was to investigate the role of the urinary chiro- and myo-inositol levels in predicting type 2 diabetes mellitus (T2DM).
  
  
  METHODS
  A total of 212 normal controls and 101 type 2 diabetic patients were enrolled this study. The concentrations of urinary chiro- and myo-inositol were measured by high performance liquid chromatography/mass spectrometry.
  
  
  RESULTS
  The concentration of urinary chiro-inositol was significantly higher in the diabetic subjects (2.24 ± 5.18 ng/L) than those in the control group (0.38 ± 0.62 ng/L; p < 0.001). The urinary myo-inositol level of the diabetic subjects (36.95 ± 37.77 ng/L) was also significantly higher than that of the controls (8.17 ± 13.29 ng/L; p < 0.001). The urinary chiro-inositol multiplied by myo-inositol level of the diabetic subjects (148.10 ± 544.91) was significantly higher than in the controls (5.12 ± 24.15; p < 0.001). The area under the receiver operating characteristic curve for the urinary chiro-inositol multiplied by myo-inositol level to predict T2DM was 0.840 (confidence interval 0.789-0.891, p < 0.001). The cut-off value for the urinary chiro-inositol multiplied by myo-inositol level to predict T2DM was 2.20 (sensitivity 81.3%, specificity 70.3%).
  
  
  CONCLUSIONS
  The urinary chiro- and myo-inositol concentrations were increased in the type 2 diabetic patients and the urinary chiro- times the myo-inositol was considered to be a sufficient marker in predicting T2DM.
authors.affiliation: Department of Internal Medicine, Chungnam National University School of Medicine, Daejeon, Korea.
authors.forename: Jun Hwa
authors.initials: JH
authors.lastname: Hong
authors.forename: Hye Won
authors.initials: HW
authors.lastname: Jang
authors.forename: Yea Eun
authors.initials: YE
authors.lastname: Kang
authors.forename: Ju Hee
authors.initials: JH
authors.lastname: Lee
authors.forename: Koon Soon
authors.initials: KS
authors.lastname: Kim
authors.forename: Hyun Jin
authors.initials: HJ
authors.lastname: Kim
authors.forename: Kyu Ri
authors.initials: KR
authors.lastname: Park
authors.forename: Bon Jeong
authors.initials: BJ
authors.lastname: Ku
mesh_terms: D000328:Adult; D000368:Aged; D015415:Biomarkers / Q000652:urine; D016022:Case-Control Studies; D003924:Diabetes Mellitus, Type 2 / Q000175:diagnosis* / Q000652:urine; D005260:Female; D006801:Humans; D007294:Inositol / Q000652:urine*; D008297:Male; D008875:Middle Aged
chemical_list: D015415:Biomarkers; D007294:Inositol