title: Breast cancer therapies and cardiomyopathy.
abstract: The prevalence of chemotherapy-related cardiac disease is increasing and management demands a multidisciplinary approach from cardiologists and oncologists. Pretreatment identification of predisposing risk factors and assessment of cardiac function before and at intervals during and after therapy with cardiotoxic agents are necessary. In clinical practice, surveillance is largely performed using transthoracic echocardiography or multi-gated radionuclide angiography. Imaging strategies that detect cardiac injury before overt left ventricular systolic dysfunction provide an opportunity for early intervention and improved cardiac outcomes.
authors.affiliation: Division of Cardiovascular Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA.
authors.forename: John
authors.initials: J
authors.lastname: Groarke
authors.forename: Dan
authors.initials: D
authors.lastname: Tong
authors.forename: Jay
authors.initials: J
authors.lastname: Khambhati
authors.forename: Susan
authors.initials: S
authors.lastname: Cheng
authors.forename: Javid
authors.initials: J
authors.lastname: Moslehi
mesh_terms: D000328:Adult; D018943:Anthracyclines / Q000009:adverse effects*; D061067:Antibodies, Monoclonal, Humanized / Q000009:adverse effects; D000970:Antineoplastic Agents / Q000009:adverse effects*; D015415:Biomarkers / Q000097:blood; D001943:Breast Neoplasms / Q000188:drug therapy*; D009202:Cardiomyopathies / Q000139:chemically induced* / Q000175:diagnosis / Q000188:drug therapy; D004452:Echocardiography; D005260:Female; D015637:Gated Blood-Pool Imaging; D006321:Heart / Q000187:drug effects*; D006801:Humans; D018719:Erb-b2 Receptor Tyrosine Kinases / Q000037:antagonists & inhibitors; D018570:Risk Assessment; D000068878:Trastuzumab
chemical_list: D018943:Anthracyclines; D061067:Antibodies, Monoclonal, Humanized; D000970:Antineoplastic Agents; D015415:Biomarkers; D018719:Erb-b2 Receptor Tyrosine Kinases; D000068878:Trastuzumab; C508053:ERBB2 protein, human