title: A genetic snapshot of small cell lung cancer.
abstract: Overexpression of PARP1 and enhancer of zeste homolog 2 (EZH2) has been identified in an integrated analysis of multiple proteins involved in intracellular signaling pathways in small cell lung cancer (SCLC) cell lines. The knockdown of PARP1 and EZH2 abrogated SCLC growth. These findings provide the basis for novel predictive markers and new treatment strategies in SCLC, for which there is now a paucity of available therapies.
authors.affiliation: Catalan Institute of Oncology, Badalona, Spain. rrosell@iconcologia.net
authors.forename: Rafael
authors.initials: R
authors.lastname: Rosell
authors.forename: Luciano
authors.initials: L
authors.lastname: Wannesson
mesh_terms: D006801:Humans; D008175:Lung Neoplasms / Q000188:drug therapy* / Q000235:genetics*; D000071137:Poly (ADP-Ribose) Polymerase-1; D000067856:Poly(ADP-ribose) Polymerase Inhibitors; D040901:Proteomics / Q000379:methods*; D055752:Small Cell Lung Carcinoma / Q000188:drug therapy* / Q000235:genetics*
chemical_list: D000067856:Poly(ADP-ribose) Polymerase Inhibitors; C499320:PARP1 protein, human; D000071137:Poly (ADP-Ribose) Polymerase-1