title: Complementary roles of mitochondrial respiration and ROS signaling on cellular aging and longevity.
abstract: Although it is widely accepted that mitochondria play fundamental roles in the mechanisms of cellular and organismal aging and lifespan extension, some open questions remain concerning the requirements for aerobic energy production and the effect of the potentially hazardous reactive oxygen species (ROS) byproducts as well as their interplay with nutrition and caloric intake.
authors.affiliation: Departments of Neurology and of Biochemistry and Molecular Biology, University of Miami Miller School of Medicine, Miami, FL 33136, USA. abarrientos@med.miami.edu
authors.forename: Antoni
authors.initials: A
authors.lastname: Barrientos
mesh_terms: D000375:Aging / Q000502:physiology; D000818:Animals; D019069:Cell Respiration / Q000502:physiology*; D016922:Cellular Senescence / Q000502:physiology*; D006801:Humans; D008136:Longevity / Q000502:physiology; D008928:Mitochondria / Q000502:physiology*; D008954:Models, Biological; D018384:Oxidative Stress / Q000502:physiology; D017382:Reactive Oxygen Species / Q000378:metabolism; D015398:Signal Transduction / Q000502:physiology*
chemical_list: D017382:Reactive Oxygen Species