title: Pregnancy modifies the antibody response to trivalent influenza immunization.
abstract: We report the immunogenicity of trivalent influenza immunization in 29 pregnant women compared with 22 nonpregnant women. We obtained blood specimens on day 0 prior to 2011-2012 influenza vaccine administration and day 28 after immunization. Hemagglutination inhibition (HAI) geometric mean titers were similar before immunization but were significantly reduced by 40%-50% in pregnant women after immunization for influenza A/California(H1N1) (P = .027) and A/Perth(H3N2) (P = .037). Postimmunization HAI titers were similar between groups for influenza B/Brisbane (P = .390). The geometric mean ratio (fold increase) for influenza A(H1N1) was nonsignificantly reduced in pregnant participants (P = .089). The percentages of participants who seroconverted and achieved seroprotection were similar between groups.
authors.affiliation: Division of Infectious Diseases, Global Health Center, Cincinnati Children's Hospital Medical Center, 3333 Burnet Ave, Cincinnati, Ohip 45229, USA. elizabeth.schlaudecker@cchmc.org
authors.forename: Elizabeth P
authors.initials: EP
authors.lastname: Schlaudecker
authors.forename: Monica M
authors.initials: MM
authors.lastname: McNeal
authors.forename: Caitlin N
authors.initials: CN
authors.lastname: Dodd
authors.forename: Joseph B
authors.initials: JB
authors.lastname: Ranz
authors.forename: Mark C
authors.initials: MC
authors.lastname: Steinhoff
mesh_terms: D000328:Adult; D000914:Antibodies, Viral / Q000097:blood*; D000918:Antibody Specificity; D005260:Female; D006385:Hemagglutination Inhibition Tests; D006801:Humans; D009980:Influenza A virus / Q000145:classification / Q000276:immunology; D009981:Influenza B virus / Q000145:classification / Q000276:immunology; D007252:Influenza Vaccines / Q000276:immunology*; D007251:Influenza, Human / Q000517:prevention & control*; D011247:Pregnancy; D055815:Young Adult
chemical_list: D000914:Antibodies, Viral; D007252:Influenza Vaccines