title: Hairless promotes PPARγ expression and is required for white adipogenesis.
abstract: Adipose tissue is the largest compartment in the mammalian body for storing energy as fat, providing an important reservoir of fuel for maintaining whole body energy homeostasis. Herein, we identify the transcriptional cofactor hairless (HR) to be required for white adipogenesis. Moreover, forced expression of HR in non-adipogenic precursor cells induces adipogenic gene expression and enhances adipocyte formation under permissive conditions. HR exerts its proadipogenic effects by regulating the expression of PPARγ, one of the central adipogenic transcription factors. In conclusion, our data provide a new mechanism required for white adipogenesis.
authors.affiliation: Institute of Cell Biology, ETH Zurich, Zurich 8093, Switzerland.
authors.forename: Susann
authors.initials: S
authors.lastname: Kumpf
authors.forename: Michael
authors.initials: M
authors.lastname: Mihlan
authors.forename: Alexander
authors.initials: A
authors.lastname: Goginashvili
authors.forename: Gerald
authors.initials: G
authors.lastname: Grandl
authors.forename: Helmuth
authors.initials: H
authors.lastname: Gehart
authors.forename: Aurélie
authors.initials: A
authors.lastname: Godel
authors.forename: Juliane
authors.initials: J
authors.lastname: Schmidt
authors.forename: Julius
authors.initials: J
authors.lastname: Müller
authors.forename: Marco
authors.initials: M
authors.lastname: Bezzi
authors.forename: Arne
authors.initials: A
authors.lastname: Ittner
authors.forename: Ernesto
authors.initials: E
authors.lastname: Guccione
authors.forename: Christian
authors.initials: C
authors.lastname: Wolfrum
authors.forename: Romeo
authors.initials: R
authors.lastname: Ricci
mesh_terms: D016475:3T3 Cells; D052438:Adipocytes, White / Q000166:cytology* / Q000378:metabolism; D050156:Adipogenesis / Q000235:genetics*; D000818:Animals; D002454:Cell Differentiation; D018507:Gene Expression Regulation, Developmental; D051379:Mice; D018345:Mice, Knockout; D009154:Mutation; D047495:PPAR gamma / Q000235:genetics / Q000378:metabolism*; D014157:Transcription Factors / Q000235:genetics / Q000378:metabolism*; D014158:Transcription, Genetic
chemical_list: D047495:PPAR gamma; D014157:Transcription Factors; C088661:hr protein, mouse