title: Estimating glomerular filtration rate (GFR) in diabetes: the performance of MDRD and CKD-EPI equations in patients with various degrees of albuminuria.
abstract: OBJECTIVE
  The aim of this study was to compare the performance of Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) and Modification of Diet in Renal Disease Study (MDRD) equations in estimating GFR in a large cohort of diabetic patients with various degrees of albuminuria.
  
  
  METHODS
  In a group of 842 diabetic patients GFR was estimated from standardized creatinine, with MDRD-Study and CKD-EPI equations, and their performance evaluated regarding clinical stages of albuminuria and chronic kidney disease (CKD).
  
  
  RESULTS
  Patients with normoalbuminuria had higher eGFR when calculated by CKD-EPI, than MDRD-Study equation [median (IQR): 103 (91-115) vs 97 (85-113)mL/min/1.73 m(2), P=0.006, n=364], which significantly influenced the prevalence of stage 1 CKD [eGFR>90 mL/min/1.73 m(2): 76.7% (CKD-EPI) vs. 65.1% (MDRD-Study), P=0.005]. There were no differences between the eGFR values derived by two equations in patients with micro- and macroalbuminuria, and more advanced staging of CKD.
  
  
  CONCLUSIONS
  CKD-EPI equation might be a superior surrogate marker of GFR in patients with normoalbuminuria and hyperfiltration and could be used as a screening tool for early renal impairment in diabetes. It's validity as a marker of progression of diabetic nephropathy merits further investigation.
authors.affiliation: Institute of Clinical Chemistry and Laboratory Medicine, Merkur Teaching Hospital, Zajčeva 19, 10000 Zagreb, Croatia. vucic@idb.hr
authors.forename: Marijana
authors.initials: M
authors.lastname: Vučić Lovrenčić
authors.forename: Vanja
authors.initials: V
authors.lastname: Radišić Biljak
authors.forename: Sandra
authors.initials: S
authors.lastname: Božičević
authors.forename: Manja
authors.initials: M
authors.lastname: Prašek
authors.forename: Pajica
authors.initials: P
authors.lastname: Pavković
authors.forename: Mladen
authors.initials: M
authors.lastname: Knotek
mesh_terms: D000328:Adult; D000368:Aged; D000419:Albuminuria / Q000150:complications* / Q000503:physiopathology*; D003920:Diabetes Mellitus / Q000503:physiopathology*; D004032:Diet; D005260:Female; D005919:Glomerular Filtration Rate / Q000502:physiology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D051436:Renal Insufficiency, Chronic / Q000150:complications / Q000453:epidemiology* / Q000503:physiopathology*