title: Higher serum retinol binding protein 4 may be a predictor of weak metabolic control in chinese patients with type 2 diabetes mellitus.
abstract: OBJECTIVE
  To investigate relationships between serum levels of retinol binding protein 4 (RBP4) and clinical and metabolic variables in Chinese patients with type 2 diabetes mellitus.
  
  
  METHODS
  A total of 513 patients (286 males/227 females) provided clinical and lifestyle data and blood and urine samples for analysis. Patients were stratified into four quartile groups according to serum RBP4 concentrations.
  
  
  RESULTS
  RBP4 concentration was independently associated with gender, systolic blood pressure, serum triglyceride and creatinine levels, and estimated glomerular filtration rate (eGFR). Hypertension, dyslipidaemia, micro albuminuria and impaired eGFR (<60 ml/min per 1.73 m2) were significantly more prevalent in patients with the highest RBP4 levels than in those with the lowest levels. Increased serum RBP4 was associated with increased risk of hypertension, dyslipidaemia, micro albuminuria and impaired eGFR after adjusting for gender, age, body mass index and duration of diabetes.
  
  
  CONCLUSIONS
  Serum RBP4 may be a useful marker of overall metabolic control in Chinese patients with type 2 diabetes mellitus.
authors.affiliation: Department of Endocrinology and Metabolism, The Second Affiliated Hospital of Harbin Medical University and The Key Laboratory of Hormonal and Endocrine Diseases, Harbin Medical University, Harbin, Heilongjiang Province, China.
authors.forename: M N
authors.initials: MN
authors.lastname: Wang
authors.forename: Y B
authors.initials: YB
authors.lastname: Han
authors.forename: Q
authors.initials: Q
authors.lastname: Li
authors.forename: L
authors.initials: L
authors.lastname: Guo
authors.forename: Y M
authors.initials: YM
authors.lastname: Yang
authors.forename: W
authors.initials: W
authors.lastname: Wang
authors.forename: J C
authors.initials: JC
authors.lastname: Zhang
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000097:blood; D002681:China; D015897:Comorbidity; D003924:Diabetes Mellitus, Type 2 / Q000097:blood* / Q000453:epidemiology / Q000378:metabolism; D050171:Dyslipidemias / Q000097:blood / Q000453:epidemiology; D005260:Female; D005919:Glomerular Filtration Rate; D006801:Humans; D006973:Hypertension / Q000097:blood / Q000453:epidemiology; D015994:Incidence; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D051437:Renal Insufficiency / Q000097:blood / Q000453:epidemiology; D054839:Retinol-Binding Proteins, Plasma / Q000378:metabolism*; D012189:Retrospective Studies; D012306:Risk; D018709:Statistics, Nonparametric
chemical_list: D015415:Biomarkers; C101326:RBP4 protein, human; D054839:Retinol-Binding Proteins, Plasma