title: Relationship between fasting and 2-hour postprandial plasma glucose levels and vascular complications in patients with type 2 diabetes mellitus.
abstract: OBJECTIVE
  To investigate the relationship between fasting and 2-h postprandial plasma glucose concentrations and vascular complications in type 2 diabetes.
  
  
  METHODS
  Consecutive patients with type 2 diabetes admitted for blood glucose control were grouped according to their fasting and 2-h postprandial plasma glucose levels. Frequency and severity of diabetic retinopathy and nephropathy, number of carotid artery plaques, coefficient of variation of R-R intervals (CVRR), brachial-ankle pulse wave velocity (baPWV), intima-media thickness, brain natriuretic peptide level, ankle-brachial index, and high-sensitivity C-reactive protein levels were compared.
  
  
  RESULTS
  In the 206 patients studied, mean±SD age, glycosylated haemoglobin and duration of diabetes were 63.4±13.7 years, 9.8±1.8% and 13.4±8.9 years, respectively. Patients with high fasting plasma glucose levels had a higher frequency of proliferative retinopathy than those with low fasting levels. Patients with medium or high 2-h postprandial plasma glucose levels had higher baPWV and lower CVRR, respectively, than those with low 2-h levels. There was an inverse correlation between baPWV and CVRR.
  
  
  CONCLUSIONS
  Elevated fasting and postprandial plasma glucose levels are risk factors for vascular complications in type 2 diabetes mellitus.
authors.affiliation: Department of Internal Medicine, School of Medicine, Keio University, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, Japan. tana176k@sepia.ocn.ne.jp
authors.forename: M
authors.initials: M
authors.lastname: Tanaka
mesh_terms: D000368:Aged; D001786:Blood Glucose; D002340:Carotid Artery Diseases / Q000097:blood; D003924:Diabetes Mellitus, Type 2 / Q000097:blood*; D003928:Diabetic Nephropathies / Q000097:blood; D003930:Diabetic Retinopathy / Q000097:blood*; D005215:Fasting; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D019518:Postprandial Period; D012307:Risk Factors; D059289:Vascular Stiffness
chemical_list: D001786:Blood Glucose