title: Cannabinoid Receptor 1 (CNR1) 4895 C/T Genetic Polymorphism was Associated with Obesity in Japanese Men.
abstract: OBJECTIVE
  The aim of this study was to investigate the association of cannabinoid receptor 1 (CNR1) 4895 C/T gene polymorphism with obesity and obesity-related cardiovascular disease (CVD) risk factors in Japanese.
  
  
  METHODS
  This study included 1,452 Japanese (678 men and 774 women, aged 25 to 74) from rural communities in Shimane Prefecture, Japan.
  
  
  RESULTS
  The frequency of the C minor allele of CNR1 4895 C/T polymorphism was 47%. In men, the CC genotype carriers showed significantly greater body mass index (BMI) and waist circumference (WC) values than T allele carriers, even after adjusting for age and medications for hypertension, dyslipidemia and type 2 diabetes. The frequency of obesity (BMI ≥25 kg/m(2)) in CC genotype carriers was significantly greater than in T allele carriers (31.8% vs 21.5%), but the frequency of central obesity (WC ≥85 for men and WC ≥90 cm for women) was not significant by CNR1 4895 C/T genotype. CC genotype carriers of CNR1 4895 C/T showed, in logistic regression analysis, significantly greater odds for obesity than T allele carriers, even after adjustment for age and the above-mentioned medications. Systolic blood pressure (SBP) values were also significantly different between the CC genotype and T allele carriers after controlling for age, medications for hypertension, dyslipidemia, and type 2 diabetes, and BMI or WC.
  
  
  CONCLUSIONS
  This study supports the association of CNR1 4895 C/T with interindividual differences in obesity in men.
authors.affiliation: Department of Environmental & Preventive Medicine, Shimane University School of Medicine, Shimane, Japan.
authors.forename: Paulin Beya Wa Bitadi
authors.initials: PB
authors.lastname: Mutombo
authors.forename: Masayuki
authors.initials: M
authors.lastname: Yamasaki
authors.forename: Toru
authors.initials: T
authors.lastname: Nabika
authors.forename: Kuninori
authors.initials: K
authors.lastname: Shiwaku
mesh_terms: D015992:Body Mass Index; D002318:Cardiovascular Diseases / Q000209:etiology*; D016022:Case-Control Studies; D004247:DNA / Q000032:analysis / Q000235:genetics; D003924:Diabetes Mellitus, Type 2 / Q000503:physiopathology*; D050171:Dyslipidemias / Q000150:complications / Q000235:genetics*; D005838:Genotype; D006801:Humans; D006973:Hypertension / Q000150:complications / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000150:complications / Q000235:genetics*; D016133:Polymerase Chain Reaction; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D011379:Prognosis; D043884:Receptor, Cannabinoid, CB1 / Q000235:genetics*; D012307:Risk Factors; D055105:Waist Circumference
chemical_list: C571130:CNR1 protein, human; D043884:Receptor, Cannabinoid, CB1; D004247:DNA