title: Behavioural actions of two new 1-N substituted analogues of melatonin.
abstract: Melatonin has been mainly used for alleviating some disorders related with insomnia and circadian rhythmicity. The use of this hormone has been limited, among others, due to its short half-life and instability. This study reports some behavioural actions of two new melatonin analogues that incorporate a phenyl or a benzoyl group at the nitrogen atom of the melatonin molecule. Although diazepam was about 10 times more potent than either of the melatonin analogues, results show that in general these last display better anxiolytic, anticonvulsant and sedative actions than the original molecule.
authors.affiliation: Escuela Superior de Medicina, IPN, Plan de San Luis y Díaz Mirón Col. Sto. Tomás, México 11340, D.F., Mexico.
authors.forename: Ruth
authors.initials: R
authors.lastname: Bustamante-García
authors.affiliation: Departamento de Farmacia, Facultad de Química, UNAM, Cd. Universitaria, Coyoacán, 04510 México, D.F., Mexico.
authors.forename: Elia B
authors.initials: EB
authors.lastname: Naranjo-Rodríguez
authors.affiliation: Departamento de Farmacia, Facultad de Química, UNAM, Cd. Universitaria, Coyoacán, 04510 México, D.F., Mexico.
authors.forename: Alfonso S
authors.initials: AS
authors.lastname: Lira-Rocha
authors.affiliation: Departamento de Farmacia, Facultad de Química, UNAM, Cd. Universitaria, Coyoacán, 04510 México, D.F., Mexico.
authors.forename: Alejandro
authors.initials: A
authors.lastname: Ortiz-Osornio
authors.affiliation: Escuela Superior de Medicina, IPN, Plan de San Luis y Díaz Mirón Col. Sto. Tomás, México 11340, D.F., Mexico. Electronic address: rifo99mx@yahoo.com.mx.
authors.forename: Ofir
authors.initials: O
authors.lastname: Picazo
mesh_terms: D000818:Animals; D014151:Anti-Anxiety Agents / Q000494:pharmacology; D000927:Anticonvulsants / Q000494:pharmacology; D000975:Antioxidants / Q000494:pharmacology*; D001007:Anxiety / Q000523:psychology; D001522:Behavior, Animal / Q000187:drug effects*; D003975:Diazepam / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D005106:Exploratory Behavior / Q000187:drug effects; D006993:Hypnotics and Sedatives / Q000494:pharmacology; D008297:Male; D008550:Melatonin / Q000031:analogs & derivatives* / Q000494:pharmacology*; D051379:Mice; D009043:Motor Activity / Q000187:drug effects; D004856:Postural Balance / Q000187:drug effects; D012640:Seizures / Q000139:chemically induced / Q000517:prevention & control
chemical_list: D014151:Anti-Anxiety Agents; D000927:Anticonvulsants; D000975:Antioxidants; D006993:Hypnotics and Sedatives; C580581:N-(2-(1-(4-chlorophenyl)-5-methoxy-1H-indole-3-yl)ethyl)acetamide; C580580:N-(2-(1-(4-cyanobenzoyl)-5-methoxy-1H-indole-3-yl)ethyl)acetamide; D008550:Melatonin; D003975:Diazepam