title: Ceramide, cerebroside and triterpenoid saponin from the bark of aerial roots of Ficus elastica (Moraceae).
abstract: Three compounds, ficusamide (1), ficusoside (2) and elasticoside (3), were isolated from the bark of aerial roots of Ficus elastica (Moraceae), together with nine known compounds, including four triterpenes, three steroids and two aliphatic linear alcohols. The chemical structures of the three compounds were established by extensive 1D and 2D NMR spectroscopy, mass spectrometry and by comparison with published data. The growth inhibitory effect of the crude extract and isolated compounds was evaluated against several microorganisms and fungi. The cytotoxicity against human cancer cell lines was also assessed. Ficusamide (1) displayed a moderate in vitro growth inhibitory activity against the human A549 lung cancer cell line and a strong activity against Staphylococcus saprophyticus, while elasticoside (3) showed a potent activity on Enterococcus faecalis.
authors.affiliation: Laboratory of Biopolymers and Supramolecular Nanomaterials, Faculté de Pharmacie, Université Libre de Bruxelles-ULB, Campus Plaine-CP 206/4, Boulevard du Triomphe, B-1050 Brussels, Belgium. jmbossot@ulb.ac.be
authors.forename: Emmanuel Jean Teinkela
authors.initials: EJ
authors.lastname: Mbosso
authors.forename: Jules Clément Assob
authors.initials: JC
authors.lastname: Nguedia
authors.forename: Franck
authors.initials: F
authors.lastname: Meyer
authors.forename: Bruno Ndjakou
authors.initials: BN
authors.lastname: Lenta
authors.forename: Silvère
authors.initials: S
authors.lastname: Ngouela
authors.forename: Benjamin
authors.initials: B
authors.lastname: Lallemand
authors.forename: Véronique
authors.initials: V
authors.lastname: Mathieu
authors.forename: Pierre Van
authors.initials: PV
authors.lastname: Antwerpen
authors.forename: Anna Longdoh
authors.initials: AL
authors.lastname: Njunda
authors.forename: Dieudonné
authors.initials: D
authors.lastname: Adiogo
authors.forename: Etienne
authors.initials: E
authors.lastname: Tsamo
authors.forename: Yvan
authors.initials: Y
authors.lastname: Looze
authors.forename: Robert
authors.initials: R
authors.lastname: Kiss
authors.forename: René
authors.initials: R
authors.lastname: Wintjens
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D004354:Drug Screening Assays, Antitumor; D013293:Enterococcus faecalis / Q000187:drug effects*; D006801:Humans; D008826:Microbial Sensitivity Tests; D008968:Molecular Conformation; D029586:Moraceae / Q000737:chemistry*; D035261:Plant Components, Aerial / Q000737:chemistry; D018517:Plant Roots / Q000737:chemistry; D012503:Saponins / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D057790:Staphylococcus saprophyticus / Q000187:drug effects*; D013329:Structure-Activity Relationship
chemical_list: D000900:Anti-Bacterial Agents; D000972:Antineoplastic Agents, Phytogenic; D012503:Saponins