title: [Case of acquired hepatocerebral degeneration with prominent improvement of parkinsonism and cognitive deficits after living-donor liver transplantation].
abstract: A 53-year-old woman visited us for a neurological consultation before her liver transplantation. She had a history of primary biliary cirrhosis that began at 37 years of age. She showed falling episodes and met with a traffic accident at 52 years old. Since then, her symptoms had worsened. The neurological examination showed masked face, rigidity on bilateral arms and legs, and lack of balance. Her Mini-Mental State Examination Score was 28/30, but she suffered from loss of memory and had trouble with executive function in detailed examinations. Her T(1) weighted image showed hyperintensity in bilateral globus pallidus, putamen, dentate nucleus and cerebral peduncle. There was a significant improvement in intellectual function and neurological signs 6 months after her orthotopic liver transplantation. In addition, post-liver transplantation images showed a decrease in the area of hyperintensities. This case suggests that even in a patient with severe liver cirrhosis a complete cure of neurological manifestations can be obtained after the liver transplantation.
authors.affiliation: Department of Neurology, Nagoya University Graduate School of Medicine.
authors.forename: Tetsuro
authors.initials: T
authors.lastname: Ishihara
authors.forename: Mizuki
authors.initials: M
authors.lastname: Ito
authors.forename: Hirohisa
authors.initials: H
authors.lastname: Watanabe
authors.forename: Masatoshi
authors.initials: M
authors.lastname: Ishigami
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Kiuchi
authors.forename: Gen
authors.initials: G
authors.lastname: Sobue
mesh_terms: D003072:Cognition Disorders / Q000209:etiology*; D005260:Female; D006527:Hepatolenticular Degeneration / Q000209:etiology* / Q000473:pathology / Q000601:surgery*; D006801:Humans; D008105:Liver Cirrhosis, Biliary / Q000150:complications* / Q000601:surgery*; D016031:Liver Transplantation; D019520:Living Donors; D008279:Magnetic Resonance Imaging; D008875:Middle Aged; D020734:Parkinsonian Disorders / Q000209:etiology*; D016896:Treatment Outcome