title: In vivo fluorescence imaging with Ag2S quantum dots in the second near-infrared region.
abstract: Hits the dot: Ag(2)S quantum dots (QDs) with bright near-infrared-II fluorescence emission (around 1200 nm) and six-arm branched PEG surface coating were synthesized for in vivo small-animal imaging. The 6PEG-Ag(2)S QDs afforded a tumor uptake of approximately 10 % injected dose/gram, owing to a long circulation half-life of approximately 4 h. Clearance of the injected 6PEG-Ag(2)S QDs occurs mainly through the biliary pathway in mice.
authors.affiliation: Department of Chemistry, Stanford University, Stanford, CA 94305, USA.
authors.forename: Guosong
authors.initials: G
authors.lastname: Hong
authors.forename: Joshua T
authors.initials: JT
authors.lastname: Robinson
authors.forename: Yejun
authors.initials: Y
authors.lastname: Zhang
authors.forename: Shuo
authors.initials: S
authors.lastname: Diao
authors.forename: Alexander L
authors.initials: AL
authors.lastname: Antaris
authors.forename: Qiangbin
authors.initials: Q
authors.lastname: Wang
authors.forename: Hongjie
authors.initials: H
authors.lastname: Dai
mesh_terms: D000818:Animals; D005260:Female; D005456:Fluorescent Dyes / Q000737:chemistry; D051379:Mice; D008807:Mice, Inbred BALB C; D009369:Neoplasms / Q000175:diagnosis*; D061848:Optical Imaging / Q000379:methods*; D045663:Quantum Dots; D018030:Silver Compounds / Q000737:chemistry; D019265:Spectroscopy, Near-Infrared / Q000379:methods
chemical_list: D005456:Fluorescent Dyes; D018030:Silver Compounds; C013251:silver sulfide