title: Analysis of Vis-NIR spectra changes to measure the inflammatory response in the nasal mucosal region of influenza A and B virus-infected patients.
abstract: BACKGROUND
  Human influenza A and B viruses cause severe seasonal respiratory tract infections, especially in infants and young children. Influenza A and B viruses have been reported to produce different symptoms and/or severity in infected patients, although these remain inconclusive.
  
  
  OBJECTIVE
  In this study, non-invasive visible and near-infrared (Vis-NIR) spectroscopy was used for comparative analysis of the inflammatory response to influenza A and B virus infections, by measuring changes in water peak (970 nm) spectra collected from patient nasal mucosal regions.
  
  
  RESULTS
  The results suggested that infection with influenza B virus induced more severe inflammatory responses in the nasal mucosal region than influenza A virus.
  
  
  CONCLUSIONS
  These are the first data showing different inflammatory responses to influenza A and B viruses at the sites of virus infection.
authors.affiliation: Department of Virology, Center for Infectious Disease Control, Research Institute for Microbial Diseases, Osaka University, Yamadaoka, Suita, Osaka 565-0871, Japan. sakudo@med.u-ryukyu.ac.jp
authors.forename: Akikazu
authors.initials: A
authors.lastname: Sakudo
authors.forename: Koichi
authors.initials: K
authors.lastname: Baba
authors.forename: Kazuyoshi
authors.initials: K
authors.lastname: Ikuta
mesh_terms: D012634:Bodily Secretions / Q000737:chemistry*; D002675:Child, Preschool; D006801:Humans; D007223:Infant; D009980:Influenza A virus / Q000472:pathogenicity*; D009981:Influenza B virus / Q000472:pathogenicity*; D007251:Influenza, Human / Q000175:diagnosis* / Q000473:pathology* / Q000821:virology; D009297:Nasal Mucosa / Q000737:chemistry*; D013057:Spectrum Analysis / Q000379:methods*