title: Conditional deletion of TrkC does not modify limbic epileptogenesis.
abstract: The neurotrophin receptor, tropomyosin-related kinase B (TrkB), is required for epileptogenesis in the kindling model. The role of a closely related neurotrophin receptor, TrkC, in limbic epileptogenesis is unknown. We examined limbic epileptogenesis in the kindling model in TrkC conditional null mice, using a strategy that previously established a critical role of TrkB. Despite elimination of TrkC mRNA, no differences in development of kindling were detected between TrkC conditional null and wild type control mice. These findings reinforce the central role of TrkB as the principal neurotrophin receptor involved in limbic epileptogenesis.
authors.affiliation: Department of Neurobiology, Duke University Medical Center, Durham, NC 27710, USA.
authors.forename: A
authors.initials: A
authors.lastname: Soren Leonard
authors.forename: Ram S
authors.initials: RS
authors.lastname: Puranam
authors.forename: Jeffrey
authors.initials: J
authors.lastname: Helgager
authors.forename: Gumei
authors.initials: G
authors.lastname: Liu
authors.forename: James O
authors.initials: JO
authors.lastname: McNamara
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D004827:Epilepsy / Q000235:genetics* / Q000503:physiopathology; D017353:Gene Deletion; D019426:Integrases / Q000235:genetics; D007696:Kindling, Neurologic / Q000235:genetics; D008032:Limbic System / Q000503:physiopathology*; D008562:Membrane Glycoproteins / Q000235:genetics*; D051379:Mice; D018345:Mice, Knockout; D011505:Protein-Tyrosine Kinases / Q000235:genetics*; D012333:RNA, Messenger / Q000235:genetics; D020812:Receptor, trkC / Q000235:genetics*; D020813:Receptor, trkB
chemical_list: D019426:Integrases; D008562:Membrane Glycoproteins; D011505:Protein-Tyrosine Kinases; D012333:RNA, Messenger; D020812:Receptor, trkC; C064371:Ntrk2 protein, mouse; D020813:Receptor, trkB; C045073:Cre recombinase