title: Management of precancerous lesions prior to conception and during pregnancy: a narrative review of the literature.
abstract: Special considerations aiming at preserving reproductive function have to be implemented when treating young patients with precancerous lesions of the lower genital tract. These high-grade lesions may progress into invasive cancer if left untreated. Currently, there are limited data on the impact of vulvar and vaginal precancerous lesions on fertility and its management during pregnancy. However, management and outcomes for cervical lesions have been extensively reported. The main approach for vulvar and vaginal lesions are maintaining anatomical function and cosmetics; whereas, treatment options for cervical precancerous lesions range from observation, cryotherapy or the more aggressive conisation. Gestational age is the most important factor in determining expectant management or surgical intervention. This narrative review draws attention to the relevant aspects of precancerous lesions of the lower genital tract, the potential effects and management prior to conception and during pregnancy.
authors.affiliation: Department of Obstetrics and Gynecology, Taipei Veterans General Hospital, Taipei, Taiwan.
authors.forename: J-Y
authors.initials: JY
authors.lastname: Tseng
authors.forename: E
authors.initials: E
authors.lastname: Bastu
authors.forename: F
authors.initials: F
authors.lastname: Gungor-Ugurlucan
mesh_terms: D002278:Carcinoma in Situ / Q000628:therapy*; D003376:Counseling; D005260:Female; D005833:Genital Neoplasms, Female / Q000628:therapy*; D006801:Humans; D007247:Infertility, Female / Q000517:prevention & control; D011230:Precancerous Conditions / Q000628:therapy*; D016742:Preconception Care / Q000379:methods*; D011247:Pregnancy; D011252:Pregnancy Complications, Neoplastic / Q000628:therapy*; D011295:Prenatal Care / Q000379:methods*; D002583:Uterine Cervical Neoplasms / Q000628:therapy; D014625:Vaginal Neoplasms / Q000628:therapy; D014846:Vulvar Neoplasms / Q000628:therapy; D002578:Uterine Cervical Dysplasia / Q000628:therapy