title: Chronotherapeutic drug delivery.
abstract: Living organisms follow a circadian rhythm in which physiological processes such as hormonal secretion, metabolism, heart rate, and renal output are affected by the time of day. Chronotherapy coordinates drug delivery with the circadian rhythm to enhance effectiveness and mitigate adverse effects and is achieved by delivering a drug when the system is most susceptible. Cancer is a chronotherapeutic disorder. Cancer treatment requires high doses of intravenous medication to kill cancerous cells; however, normal cells are also killed, creating intolerable side effects. This review shows that chronotherapy can play a vital role in the quality of life and survival rate for oncology patients.
authors.affiliation: Department of Pharmacy, Banner Good Samaritan Medical Center, Phoenix, Arizona 85006, USA. paul.alcantaralibrodo@bannerhealth.com
authors.forename: Paul
authors.initials: P
authors.lastname: Librodo
authors.forename: Mitchell
authors.initials: M
authors.lastname: Buckley
authors.forename: Marilyn
authors.initials: M
authors.lastname: Luk
authors.forename: Andrea
authors.initials: A
authors.lastname: Bisso
mesh_terms: D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D019454:Chronotherapy / Q000379:methods*; D002940:Circadian Rhythm; D016503:Drug Delivery Systems; D005260:Female; D006801:Humans; D007262:Infusions, Intravenous / Q000379:methods / Q000451:nursing*; D008175:Lung Neoplasms / Q000188:drug therapy; D009369:Neoplasms / Q000188:drug therapy* / Q000451:nursing; D009859:Oncology Nursing / Q000379:methods*
chemical_list: D000970:Antineoplastic Agents