title: Microwave-assisted synthesis of 4-chloro-N-(naphthalen-1-ylmethyl)-5-(3-(piperazin-1-yl)phenoxy)thiophene-2-sulfonamide (B-355252): a new potentiator of Nerve Growth Factor (NGF)-induced neurite outgrowth.
abstract: The synthesis of 4-chloro-N-(naphthalen-1-ylmethyl)-5-(3-(piperazin-1-yl)phenoxy)thiophene-2-sulfonamide (B-355252) using a MW-assisted nucleophilic aromatic substitution (S(N)Ar) reaction will be discussed. Utilization of this method allowed for the rapid generation of B-355252 heteroaryl ether core structure in the presence of cesium carbonate in dimethylformamide or tripotassium phosphate in N-methyl-2-pyrrolidone in 94% yield. Evaluation of B-355252 enhancement of nerve growth factor's ability to stimulate neurite outgrowths was determined using NS-1 cells.
authors.affiliation: Department of Pharmaceutical Sciences, North Carolina Central University, Durham, NC, 27707 USA 2.
authors.forename: Alfred L
authors.initials: AL
authors.lastname: Williams
authors.forename: Srinivasa R
authors.initials: SR
authors.lastname: Dandepally
authors.forename: Nailya
authors.initials: N
authors.lastname: Gilyazova
authors.forename: Sam M
authors.initials: SM
authors.lastname: Witherspoon
authors.forename: Gordon
authors.initials: G
authors.lastname: Ibeanu