title: Sequential analysis of diethylnitrosamine-induced hepatocarcinogenesis in rats.
abstract: In the present study, we examined the sequential changes of diethylnitrosamine (DEN)-induced hepatocarcinogenesis in Wistar rats. After 14 weeks of DEN treatment, hyperplastic nodules developed as a consequence of the appearance of renewed hepatocytes, degenerated hepatocytes, oval cells and fibrotic changes. Total bilirubin and alanine aminotransferase levels were significantly higher in the DEN group compared to the control group throughout the experimental period. Our data may prove beneficial to future analyses of chemopreventive compounds during various stages of hepatocarcinogenesis in rats.
authors.affiliation: Second Department of Internal Medicine, Tottori University School of Medicine, Yonago, Tottori 683-8504, Japan.
authors.forename: Ryo
authors.initials: R
authors.lastname: Abe
authors.forename: Jun-Ichi
authors.initials: JI
authors.lastname: Okano
authors.forename: Ryu
authors.initials: R
authors.lastname: Imamoto
authors.forename: Yuki
authors.initials: Y
authors.lastname: Fujise
authors.forename: Yoshikazu
authors.initials: Y
authors.lastname: Murawaki