title: Chronic eyelid swelling as an initial manifestation of myeloma-associated amyloidosis.
abstract: Orbital amyloidosis is uncommon and difficult to diagnose due to their variable clinical presentations. The authors report a case of a patient who presents with chronic eyelid swelling as an initial manifestation of myeloma-associated amyloidosis. This patient was also found to have retrobulbar infiltration with no visual impairment. The authors also describe the first documentation of the atypical necrotic appearance of amyloidosis in the involved eyelid tissues. Myeloma-associated amyloidosis can present as chronic, nonspecific periorbital swelling, hence a biopsy of the affected tissues is important in preventing a delay in the correct diagnosis.
authors.affiliation: Singapore National Eye Center, Singapore.
authors.forename: Elaine
authors.initials: E
authors.lastname: Chee
authors.forename: Yoon-Duck
authors.initials: YD
authors.lastname: Kim
authors.forename: Jung Hye
authors.initials: JH
authors.lastname: Lee
authors.forename: Kyung In
authors.initials: KI
authors.lastname: Woo
mesh_terms: D000686:Amyloidosis / Q000175:diagnosis* / Q000628:therapy; D001706:Biopsy; D019882:Blepharoplasty; D003131:Combined Modality Therapy; D003520:Cyclophosphamide; D004359:Drug Therapy, Combination; D004487:Edema / Q000175:diagnosis* / Q000628:therapy; D005141:Eyelid Diseases / Q000175:diagnosis* / Q000628:therapy; D005938:Glucocorticoids / Q000627:therapeutic use; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009101:Multiple Myeloma / Q000175:diagnosis* / Q000628:therapy; D011239:Prednisolone / Q000627:therapeutic use; D033581:Stem Cell Transplantation; D013792:Thalidomide / Q000627:therapeutic use; D014057:Tomography, X-Ray Computed; D014182:Transplantation, Autologous
chemical_list: D005938:Glucocorticoids; D007166:Immunosuppressive Agents; D013792:Thalidomide; D003520:Cyclophosphamide; D011239:Prednisolone