title: Advances in research on G protein-coupled inward rectifier K(+) channel gene.
abstract: G protein-coupled inward rectifier K(+) channel 4(GIRK4) is a G protein-coupled inward rectifier potassium channel family member. Encoded by the KCNJ5, it is widely distributed in the mammalian heart, brain, and other tissues and organs. Recent studies have demonstrated that the abnormal expression of GIRK4 gene is associated with atrial fibrillation, and meanwhile may be closely related to obesity, metabolic syndrome, and many other clinical conditions. Further research on the role the GIRK4 gene in the pathophysiology of these clinical conditions will definitely facilitate their clinical diagnosis and treatment.
authors.affiliation: Medical College of Shihezi University, Shihezi, Xinjiang, China.
authors.forename: Yong-an
authors.initials: YA
authors.lastname: Kang
authors.forename: Yan-rong
authors.initials: YR
authors.lastname: Hu
authors.forename: Nan-fang
authors.initials: NF
authors.lastname: Li
mesh_terms: D001281:Atrial Fibrillation / Q000235:genetics; D051676:G Protein-Coupled Inwardly-Rectifying Potassium Channels / Q000235:genetics*; D006801:Humans; D024821:Metabolic Syndrome / Q000235:genetics
chemical_list: D051676:G Protein-Coupled Inwardly-Rectifying Potassium Channels; C484274:KCNJ5 protein, human