title: The cytotoxic activity of diterpenoids from Isodon species.
abstract: Fifteen Isodon diterpenoids (1-15) were evaluated for their cytotoxic activity against HeLa and HL-60 human cancer cell lines, and against murine vincristine (VCR)-resistant P388 cells. Kamebanin (14) showed efficient cytotoxic activity against HeLa and HL-60 cells. In addition, although dihydroenmein (2) and trichorabdal B (7) were inactive against several tested cell types, they were found to have cytotoxic-enhancing activity of VCR against VCR-resistant P388 cells.
authors.affiliation: Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University 2-3-10, Kanda Surugadai, Chiyoda-ku, Tokyo 101-0062, Japan. a-ohsaki.chem@tmd.ac.jp
authors.forename: Ayumi
authors.initials: A
authors.lastname: Ohsaki
authors.forename: Masaaki
authors.initials: M
authors.lastname: Ozawa
authors.forename: Kanki
authors.initials: K
authors.lastname: Komiyama
authors.forename: Akio
authors.initials: A
authors.lastname: Kishida
authors.forename: Takahiko
authors.initials: T
authors.lastname: Isobe
mesh_terms: D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry* / Q000494:pharmacology*; D002460:Cell Line; D004224:Diterpenes / Q000737:chemistry* / Q000494:pharmacology*; D006801:Humans; D037602:Isodon / Q000737:chemistry*; D051379:Mice; D015394:Molecular Structure
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D004224:Diterpenes