title: Antiretrovirals for HIV Exposure Prophylaxis.
abstract: Infection with Human Immunodeficiency Virus (HIV) remains a global public health problem. Although the epidemic has not been completely controlled, there was considerable progress in HIV prevention and treatment during the last 30 years. The modern prevention approaches are multi-component including also the administration of combinations of potent antiretroviral agents as a prophylaxis after occupational or non-occupational exposures to HIV. The aim of the current review is to present the chemical and pharmacological characteristics of antiretroviral drugs used in HIV prophylaxis and to describe briefly the medical management of exposures to potentially infectious body fluids.
authors.affiliation: Hellenic Centre for Disease Control and Prevention, 3-5 Agrafon Str., 15123 Maroussi, Athens, Greece. gknikolopoulos@gmail.com
authors.forename: G
authors.initials: G
authors.lastname: Nikolopoulos
authors.forename: S
authors.initials: S
authors.lastname: Tsiodras
authors.forename: S
authors.initials: S
authors.lastname: Bonovas
authors.forename: A
authors.initials: A
authors.lastname: Hatzakis
mesh_terms: D000225:Adenine / Q000031:analogs & derivatives / Q000494:pharmacology / Q000627:therapeutic use; D019380:Anti-HIV Agents / Q000494:pharmacology / Q000627:therapeutic use*; D003841:Deoxycytidine / Q000031:analogs & derivatives / Q000494:pharmacology / Q000627:therapeutic use; D015224:Dideoxynucleosides / Q000494:pharmacology / Q000627:therapeutic use; D000068679:Emtricitabine; D006678:HIV / Q000187:drug effects; D015658:HIV Infections / Q000188:drug therapy* / Q000517:prevention & control; D006801:Humans; D019259:Lamivudine / Q000494:pharmacology / Q000627:therapeutic use; D016273:Occupational Exposure; D063065:Organophosphonates / Q000494:pharmacology / Q000627:therapeutic use; D018119:Stavudine / Q000494:pharmacology / Q000627:therapeutic use; D000068698:Tenofovir; D015215:Zidovudine / Q000494:pharmacology / Q000627:therapeutic use; D000099227:Abacavir
chemical_list: D000225:Adenine; D019380:Anti-HIV Agents; D003841:Deoxycytidine; D015224:Dideoxynucleosides; D000068679:Emtricitabine; D019259:Lamivudine; D063065:Organophosphonates; D018119:Stavudine; D000068698:Tenofovir; D015215:Zidovudine; D000099227:Abacavir