title: False-positive amphetamine/ecstasy (MDMA/3,4-methylenedioxymethamphetamine) (CEDIA) and ecstasy (MDMA/3,4-methylenedioxymethamphetamine) (DRI) test results with fenofibrate.
abstract: This case report describes a false-positive amphetamine/ecstasy [3,4-methylenedioxymethamphetamine (MDMA)] and ecstasy (MDMA) screen after therapeutic use of antihyperlipidemic drug, fenofibrate. A 60-year-old male patient was admitted to inpatient psychiatry unit with the diagnosis of alcohol dependency. He was prescribed diazepam 30 mg/day, thiamine 300 mg/day, and naltrexone 50 mg/day. He had also been using fenofibrate 267 mg/day for 3 years for hyperlipidemia and trazodone 100 mg/day for 5 months for insomnia. On routine, urine drugs-of-abuse screening amphetamine/MDMA (CEDIA) test was positive for 4 different occasions and MDMA (DRI) test was positive on 5 different occasions. Gas chromatography/mass spectrometry confirmation of the first positive 3 samples were negative for amphetamine and MDMA. After discontinuation of fenofibrate, amphetamine/MDMA, and MDMA immunoassay results turned out to be negative. Caution should be given to interpretation of amphetamine/MDMA (CEDIA) and MDMA (DRI) tests in patients taking fenofibrate. Specific confirmation with a suitable method should be used to prevent erroneous interpretations.
authors.affiliation: Department of Pharmacology, Clinical Pharmacology, and Toxicology Unit, Izmir Katip Celebi University Faculty of Medicine, Ataturk Training and Research Hospital, Izmir, Turkey. seawise@gmail.com
authors.forename: Yusuf Cem
authors.initials: YC
authors.lastname: Kaplan
authors.forename: Almla
authors.initials: A
authors.lastname: Erol
authors.forename: Barş
authors.initials: B
authors.lastname: Karadaş
mesh_terms: D000662:Amphetamines / Q000737:chemistry / Q000652:urine*; D005189:False Positive Reactions; D011345:Fenofibrate / Q000493:pharmacokinetics / Q000627:therapeutic use*; D008401:Gas Chromatography-Mass Spectrometry; D006801:Humans; D007004:Hypoglycemic Agents / Q000493:pharmacokinetics / Q000627:therapeutic use; D007118:Immunoassay / Q000379:methods; D008297:Male; D008875:Middle Aged; D018817:N-Methyl-3,4-methylenedioxyamphetamine / Q000737:chemistry / Q000652:urine*; D015813:Substance Abuse Detection / Q000379:methods
chemical_list: D000662:Amphetamines; D007004:Hypoglycemic Agents; D018817:N-Methyl-3,4-methylenedioxyamphetamine; D011345:Fenofibrate