title: Dechlorane Plus in serum from e-waste recycling workers: influence of gender and potential isomer-specific metabolism.
abstract: Dechlorane Plus (DP) and its dechlorinated product, anti-Cl₁₁-DP, were measured in serum of 70 occupationally exposed workers in an e-waste recycling region and 13 residents of an urban area in South China. The DP levels were significantly higher in the workers (22-2200 ng/g with median of 150 ng/g lipid) than in the urban residents (2.7-91 ng/g with median of 4.6 ng/g lipid). The DP concentrations in females were found to be associated with their age but such relation was not found for males. Significant differences in DP levels and DP isomer composition were found between genders. The females had remarkably higher DP levels and f(anti) values (fraction of anti-DP to total DPs) in serum than the males. Anti-Cl₁₁-DP was significantly correlated with anti-DP for both genders but with different slope of regression line. The ratios of anti-Cl₁₁-DP to anti-DP (mean of 0.017) in males were significantly higher than those (mean of 0.010) in females. Combining with the lower f(anti) values in males, it is likely that males have higher metabolic potential for DPs than females which resulted in the lower DP loading in serum. However, the different patterns of selective uptake and/or excretion of different compounds between genders cannot be eliminated as a possible reason for the observed gender differences. This study is the first to report on the gender difference in DP accumulation in human, and its mechanism is worth further investigation.
authors.affiliation: State Key Laboratory for Biocontrol, School of Life Sciences, Sun Yat-Sen University, Guangzhou 510275, China.
authors.forename: Xiao
authors.initials: X
authors.lastname: Yan
authors.forename: Jing
authors.initials: J
authors.lastname: Zheng
authors.forename: Ke-Hui
authors.initials: KH
authors.lastname: Chen
authors.forename: Junzhi
authors.initials: J
authors.lastname: Yang
authors.forename: Xiao-Jun
authors.initials: XJ
authors.lastname: Luo
authors.forename: Le-Huan
authors.initials: LH
authors.lastname: Yu
authors.forename: She-Jun
authors.initials: SJ
authors.lastname: Chen
authors.forename: Bi-Xian
authors.initials: BX
authors.lastname: Mai
authors.forename: Zhong-Yi
authors.initials: ZY
authors.lastname: Yang
mesh_terms: D000328:Adult; D000395:Air Pollutants, Occupational / Q000097:blood*; D002681:China; D059029:Electronic Waste / Q000706:statistics & numerical data*; D005260:Female; D005411:Flame Retardants / Q000378:metabolism*; D005783:Gender Identity; D006801:Humans; D006843:Hydrocarbons, Chlorinated / Q000097:blood*; D007536:Isomerism; D008297:Male; D008875:Middle Aged; D016273:Occupational Exposure / Q000032:analysis / Q000706:statistics & numerical data*; D011083:Polycyclic Compounds / Q000097:blood*; D059027:Recycling / Q000706:statistics & numerical data; D012737:Sex Factors; D055815:Young Adult
chemical_list: D000395:Air Pollutants, Occupational; D005411:Flame Retardants; D006843:Hydrocarbons, Chlorinated; D011083:Polycyclic Compounds; C526360:dechlorane plus