title: Respiratory syncytial virus infection and chronic respiratory morbidity - is there a functional or genetic predisposition?
abstract: A systematic literature review has been undertaken. Respiratory syncytial virus (RSV) lower respiratory tract infection (LRTI) in infancy is associated with chronic respiratory morbidity. Premorbid abnormal lung function may predispose to RVS LRTI in prematurely born infants.
  
  
  CONCLUSIONS
  Single-nucleotide polymorphisms in genes coding for IL-8, IL-19, IL-20, IL-13 mannose-binding lectin, IFNG and a RANTES polymorphism have been associated with subsequent wheeze following RSV LRTI in term-born infants.
authors.affiliation: Division of Asthma, Allergy and Lung Biology, the MRC and Asthma UK Centre in Allergic Mechanisms of Asthma, King's College London, UK.
authors.forename: Simon B
authors.initials: SB
authors.lastname: Drysdale
authors.forename: Anthony D
authors.initials: AD
authors.lastname: Milner
authors.forename: Anne
authors.initials: A
authors.lastname: Greenough
mesh_terms: D001249:Asthma / Q000209:etiology* / Q000235:genetics / Q000503:physiopathology; D001990:Bronchiolitis, Viral / Q000150:complications*; D002908:Chronic Disease; D003371:Cough / Q000209:etiology / Q000235:genetics / Q000503:physiopathology; D004198:Disease Susceptibility / Q000503:physiopathology; D005819:Genetic Markers; D020022:Genetic Predisposition to Disease; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007234:Infant, Premature; D007235:Infant, Premature, Diseases / Q000209:etiology / Q000235:genetics / Q000503:physiopathology; D008168:Lung / Q000503:physiopathology; D020641:Polymorphism, Single Nucleotide; D012129:Respiratory Function Tests; D012135:Respiratory Sounds / Q000209:etiology* / Q000235:genetics / Q000503:physiopathology; D018357:Respiratory Syncytial Virus Infections / Q000150:complications*
chemical_list: D005819:Genetic Markers