title: Neural regeneration in Caenorhabditis elegans.
abstract: Axon regeneration is a medically relevant process that can repair damaged neurons. This review describes current progress in understanding axon regeneration in the model organism Caenorhabditis elegans. Factors that regulate axon regeneration in C. elegans have broadly similar roles in vertebrate neurons. This means that using C. elegans as a tool to leverage discovery is a legitimate strategy for identifying conserved mechanisms of axon regeneration.
authors.affiliation: Department of Genetics, Program in Cellular Neuroscience, Neurodegeneration, and Repair, Yale University, New Haven, Connecticut 06510, USA.
authors.forename: Rachid
authors.initials: R
authors.lastname: El Bejjani
authors.forename: Marc
authors.initials: M
authors.lastname: Hammarlund
mesh_terms: D000818:Animals; D001369:Axons / Q000378:metabolism / Q000502:physiology*; D019771:Axotomy / Q000379:methods; D017173:Caenorhabditis elegans / Q000235:genetics / Q000378:metabolism / Q000502:physiology*; D029742:Caenorhabditis elegans Proteins / Q000235:genetics / Q000378:metabolism; D015220:Calcium Channels / Q000378:metabolism; D000242:Cyclic AMP / Q000378:metabolism; D020930:MAP Kinase Kinase Kinases / Q000235:genetics / Q000378:metabolism; D020935:MAP Kinase Signaling System; D035683:MicroRNAs / Q000235:genetics / Q000378:metabolism; D008870:Microtubules / Q000378:metabolism; D023421:Models, Animal; D009416:Nerve Regeneration; D009474:Neurons / Q000378:metabolism / Q000502:physiology; D020196:Trauma, Nervous System / Q000378:metabolism / Q000503:physiopathology
chemical_list: D029742:Caenorhabditis elegans Proteins; D015220:Calcium Channels; C554747:EFA-6 protein, C elegans; D035683:MicroRNAs; D000242:Cyclic AMP; C498050:DLK-1 protein, C elegans; D020930:MAP Kinase Kinase Kinases