title: Genome sequences of Brucella melitensis 16M and its two derivatives 16M1w and 16M13w, which evolved in vivo.
abstract: Brucella melitensis is an intracellular pathogen that induces chronic infection in humans. Here, we report the genome sequences of 16M and its two derivatives, 16M1w and 16M13w, which were allowed to adapt in vivo for 1 and 13 weeks, respectively. Our findings contribute to the investigation of adaptive mutations and mechanisms of chronic infection by B. melitensis.
authors.affiliation: Department of Infectious Disease Control, Beijing Institute of Disease Control and Prevention, Beijing, People's Republic of China.
authors.forename: Yuehua
authors.initials: Y
authors.lastname: Ke
authors.forename: Xitong
authors.initials: X
authors.lastname: Yuan
authors.forename: Yufei
authors.initials: Y
authors.lastname: Wang
authors.forename: Yaoxia
authors.initials: Y
authors.lastname: Bai
authors.forename: Jie
authors.initials: J
authors.lastname: Xu
authors.forename: Hongbin
authors.initials: H
authors.lastname: Song
authors.forename: Liuyu
authors.initials: L
authors.lastname: Huang
authors.forename: Zeliang
authors.initials: Z
authors.lastname: Chen
mesh_terms: D000818:Animals; D017347:Brucella melitensis / Q000145:classification* / Q000235:genetics*; D002006:Brucellosis / Q000382:microbiology*; D019143:Evolution, Molecular; D016680:Genome, Bacterial; D051379:Mice; D008807:Mice, Inbred BALB C; D008969:Molecular Sequence Data