title: Effects of photodynamic therapy for superficial esophageal squamous cell carcinoma in vivo and in vitro.
abstract: Photodynamic therapy (PDT) is an ablative treatment leading to intracellular photoexcitation and injury. A total of 15 patients with superficial esophageal squamous cell carcinoma (ESCC) without metastasis underwent PDT and 48-72 h after intravenous Photofrin, the patients were treated with a 630-nm excimer dye laser. A total of 13 patients had local tumor recurrence after definitive chemoradiotherapy (CRT) consisting of 5-fluorouracil (5-FU) and cisplatin (CDDP). Of 6 patients, 5 had submucosal ESCC and were treated with S-1. Complete reponse was achieved by 11 patients with initial PDT, but 2 had recurrences. The recurrent/residual tumors were successfully treated with repeated PDT. Two patients with intramucosal ESCC succumbed due to metastatic disease, but 11 patients were disease-free. The 5 patients treated with S-1 remained alive despite submucosal ESCC. PDT was applied to human ESCC cells in vitro in the presence or absence of 5-FU or CDDP. The combination of PDT with 5-FU or CDDP resulted in enhanced cytotoxic effects, thereby reducing the effective dosage of each drug. PDT is a promising treatment option for selected ESCC cases, particularly for local recurrence following CRT. Our experience suggests that PDT is more effective when combined with chemotherapy.
authors.affiliation: Department of Gastroenterology and Hepatology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki 852-8501, Japan.
authors.forename: Kaoru
authors.initials: K
authors.lastname: Kawazoe
authors.forename: Hajime
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authors.lastname: Isomoto
authors.forename: Naoyuki
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authors.lastname: Yamaguchi
authors.forename: Naoki
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authors.lastname: Inoue
authors.forename: Ryohei
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authors.lastname: Uehara
authors.forename: Kayoko
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authors.lastname: Matsushima
authors.forename: Tatsuki
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authors.lastname: Ichikawa
authors.forename: Fuminao
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authors.lastname: Takeshima
authors.forename: Takashi
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authors.lastname: Nonaka
authors.forename: Atsushi
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authors.lastname: Nanashima
authors.forename: Takeshi
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authors.lastname: Nagayasu
authors.forename: Masataka
authors.initials: M
authors.lastname: Uehara
authors.forename: Izumi
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authors.lastname: Asahina
authors.forename: Kazuhiko
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authors.lastname: Nakao