title: Long-term olive oil-based parenteral nutrition sustains innate immune function in home patients without active underlying disease.
abstract: OBJECTIVE
  It remains unclear whether impaired host defenses contribute to the increased risk for infectious complications seen in patients on home parenteral nutrition (HPN). The aim of this study was to compare the innate immune function of patients on olive oil-based HPN with that of healthy controls.
  
  
  METHODS
  Innate immune functions and (anti-)oxidant balance were studied in 20 patients on olive oil-based HPN without an active underlying immune-mediated disease (Clinoleic(®), ≥ 6 months; >3 times/week), and 21 age- and sex-matched healthy controls.
  
  
  RESULTS
  Neutrophils of patients and controls had a similar capacity to eliminate Streptococcus pneumoniae. Also, levels of activation markers (CD66b, CD11b, CD62L) in granulocytes and monocytes, phorbol ester- and zymosan-induced neutrophil oxygen radical production were not different between patients and controls. No differences in (anti-)oxidant status were found, except for higher concentrations of oxidized glutathione and lower plasma selenium and vitamin C in patients compared to controls.
  
  
  CONCLUSIONS
  Compromised innate immune function does not seem to explain the increased risk for infectious complications in HPN patients using olive oil-based lipid emulsions.
authors.affiliation: Department of Gastroenterology and Hepatology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands. e.olthof@mdl.umcn.nl
authors.forename: E D
authors.initials: ED
authors.lastname: Olthof
authors.forename: H M J
authors.initials: HM
authors.lastname: Roelofs
authors.forename: M W J
authors.initials: MW
authors.lastname: Versleijen
authors.forename: R H M
authors.initials: RH
authors.lastname: Te Morsche
authors.forename: E R
authors.initials: ER
authors.lastname: Simonetti
authors.forename: P W M
authors.initials: PW
authors.lastname: Hermans
authors.forename: G J A
authors.initials: GJ
authors.lastname: Wanten
mesh_terms: D000328:Adult; D015703:Antigens, CD / Q000378:metabolism; D000975:Antioxidants / Q000378:metabolism; D001205:Ascorbic Acid / Q000097:blood; D015415:Biomarkers / Q000097:blood; D039481:CD11b Antigen / Q000378:metabolism; D015815:Cell Adhesion Molecules / Q000378:metabolism; D005260:Female; D058851:GPI-Linked Proteins / Q000378:metabolism; D019803:Glutathione Disulfide / Q000097:blood; D006098:Granulocytes / Q000276:immunology; D006801:Humans; D007113:Immunity, Innate; D019041:L-Selectin / Q000378:metabolism; D015227:Lipid Peroxidation / Q000187:drug effects; D008297:Male; D008875:Middle Aged; D009000:Monocytes / Q000276:immunology; D009504:Neutrophils / Q000276:immunology; D000069463:Olive Oil; D016331:Parenteral Nutrition, Home; D010938:Plant Oils / Q000008:administration & dosage*; D012307:Risk Factors; D012643:Selenium / Q000097:blood; D013024:Soybean Oil / Q000008:administration & dosage*; D013296:Streptococcus pneumoniae
chemical_list: D015703:Antigens, CD; D000975:Antioxidants; D015415:Biomarkers; D039481:CD11b Antigen; C504120:CEACAM8 protein, human; D015815:Cell Adhesion Molecules; C568346:ClinOleic; D058851:GPI-Linked Proteins; C509295:ITGAM protein, human; D000069463:Olive Oil; D010938:Plant Oils; D019041:L-Selectin; D013024:Soybean Oil; D012643:Selenium; D001205:Ascorbic Acid; D019803:Glutathione Disulfide