title: Evaluation of hypolipidemic effects of peanut skin-derived polyphenols in rats on Western-diet.
abstract: The effect of water soluble polyphenolic extract of peanut skin (PE) was investigated for its hypolipidemic properties in rats on Western diet. Seven-weeks old Wistar rats received control diet (AIN-93G), Western diet with and without a bolus of PE five times a week for 10weeks. Group which received 300mg/kg body weight showed significantly reduced body weight and epididymal fat. Plasma and liver triglyceride (TG) and cholesterol (TC) levels were significantly reduced while faecal secretion of TG and TC was greatly increased upon PE administration. Liver mRNA expression of enzymes involved in fatty acid synthesis, such as fatty acid synthase (FAS), sterol receptor element binding protein (SREBP)-1c, acetyl-CoA carboxylase (ACC1) and lipid uptake genes, such as PPARγ, were decreased, while PPARα was up-regulated by administration of PE. These data suggest that administration of PE may contribute to the improved lipid homoeostasis in rats on diets high in cholesterol and lipids.
authors.affiliation: Center for Excellence in Post-Harvest Technologies, North Carolina Agricultural and Technical State University, North Carolina Research Campus, Kannapolis, NC 28081, USA. rbansode@ncat.edu
authors.forename: Rishipal R
authors.initials: RR
authors.lastname: Bansode
authors.forename: Priscilla
authors.initials: P
authors.lastname: Randolph
authors.forename: Steven
authors.initials: S
authors.lastname: Hurley
authors.forename: Mohamed
authors.initials: M
authors.lastname: Ahmedna
mesh_terms: D000103:Acetyl-CoA Carboxylase / Q000235:genetics / Q000378:metabolism; D000818:Animals; D010367:Arachis / Q000737:chemistry*; D002784:Cholesterol / Q000378:metabolism; D004041:Dietary Fats / Q000008:administration & dosage; D004353:Drug Evaluation, Preclinical; D006801:Humans; D000960:Hypolipidemic Agents / Q000008:administration & dosage*; D050356:Lipid Metabolism / Q000187:drug effects*; D008297:Male; D047495:PPAR gamma / Q000235:genetics / Q000378:metabolism; D010936:Plant Extracts / Q000008:administration & dosage*; D059808:Polyphenols / Q000008:administration & dosage*; D051381:Rats; D017208:Rats, Wistar; D012639:Seeds / Q000737:chemistry*; D014280:Triglycerides / Q000378:metabolism
chemical_list: D004041:Dietary Fats; D000960:Hypolipidemic Agents; D047495:PPAR gamma; D010936:Plant Extracts; D059808:Polyphenols; D014280:Triglycerides; D002784:Cholesterol; D000103:Acetyl-CoA Carboxylase