title: Clinical, histologic, and genetic features of mesothelioma in a 7-year-old child.
abstract: Malignant mesothelioma (MM) is a highly aggressive malignancy that is extremely rare in children. This case report documents a 7-year-old male without previous asbestos exposure with peritoneal MM that initially responded to chemotherapy with cisplatin and gemcitabine but ultimately metastasized to his chest. He was diagnosed with MM based on histology, extensive immunohistochemical analyses, and an elevated serum CA-125 level. Cytogenetics and comparative genomic hybridization (CGH) analysis of his tumor identified a single extra copy number of chromosome 11 with few other changes noted.
authors.affiliation: Department of Pediatrics and Greehey Children's Cancer Research Institute, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA.
authors.forename: Aaron
authors.initials: A
authors.lastname: Sugalski
authors.forename: Mary
authors.initials: M
authors.lastname: Davis
authors.forename: Latha
authors.initials: L
authors.lastname: Prasannan
authors.forename: Victor
authors.initials: V
authors.lastname: Saldivar
authors.forename: Jaclyn Y
authors.initials: JY
authors.lastname: Hung
authors.forename: Gail E
authors.initials: GE
authors.lastname: Tomlinson
mesh_terms: D018394:CA-125 Antigen / Q000097:blood; D002648:Child; D002880:Chromosomes, Human, Pair 11; D055028:Comparative Genomic Hybridization; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008654:Mesothelioma / Q000175:diagnosis* / Q000235:genetics* / Q000473:pathology / Q000628:therapy; D010534:Peritoneal Neoplasms / Q000175:diagnosis* / Q000235:genetics* / Q000473:pathology / Q000628:therapy
chemical_list: D018394:CA-125 Antigen