title: Current analytical strategies for C-reactive protein quantification in blood.
abstract: The measurement of serum C-reactive protein (CRP) levels has been given particular interest as a marker of inflammation associated with cardiovascular diseases. CRP belongs to the pentraxin family of proteins and the routine clinical analysis of CRP in blood samples is used as an important factor in primary prevention programmes together with causative and predisposing factors. This review focuses on the most representative methodologies and strategies for CRP detection and quantification that have been recently proposed, as well as reviewing those that are currently being developed for the specific, sensitive, inexpensive and high-throughput blood analysis of this protein.
authors.affiliation: Centro de Geologia, Departamento de Geociências, Ambiente e Ordenamento do Território do Porto, Faculdade de Ciências, Universidade do Porto, Porto, Portugal. magonzal@fc.up.pt
authors.forename: Manuel
authors.initials: M
authors.lastname: Algarra
authors.forename: Diana
authors.initials: D
authors.lastname: Gomes
authors.forename: Joaquim C G
authors.initials: JC
authors.lastname: Esteves da Silva
mesh_terms: D015415:Biomarkers / Q000097:blood; D002097:C-Reactive Protein / Q000032:analysis* / Q000191:economics; D002318:Cardiovascular Diseases / Q000097:blood* / Q000175:diagnosis / Q000517:prevention & control; D004983:Ethanolamines / Q000737:chemistry; D057166:High-Throughput Screening Assays / Q000191:economics / Q000592:standards* / Q000639:trends; D006801:Humans; D007118:Immunoassay; D007249:Inflammation / Q000097:blood; D054802:Molecular Imprinting; D010767:Phosphorylcholine / Q000737:chemistry; D011322:Primary Prevention; D012307:Risk Factors; D012680:Sensitivity and Specificity; D020349:Surface Plasmon Resonance
chemical_list: D015415:Biomarkers; D004983:Ethanolamines; D010767:Phosphorylcholine; C005448:phosphorylethanolamine; D002097:C-Reactive Protein