title: Near IR fluorescent polystyrene/albumin core/shell nanoparticles for specific targeting of colonic neoplasms.
abstract: Previous studies have shown that albumin has a high affinity towards tumours, and, as a result, many drug/albumin conjugates, as well as albumin nanoparticles, have been studied as antineoplastic drug carriers. Numerous studies have also shown the high affinity of cyanine dyes for albumin. This work combines the former and the latter for the preparation of NIR fluorescent and photostable nanoparticles as diagnostic biomaterials. Tumour-specific labelling by NIR fluorescent polystyrene/albumin core/shell nanoparticles is demonstrated, without the presence of additional targeting moieties, and they possess great potential for clinical applications.
authors.affiliation: Department of Chemistry, Bar-Ilan Institute of Nanotechnology and Advanced Materials, Bar-Ilan University, Ramat Gan, 52900, Israel.
authors.forename: Michal
authors.initials: M
authors.lastname: Pellach
authors.forename: Igor
authors.initials: I
authors.lastname: Grinberg
authors.forename: Shlomo
authors.initials: S
authors.lastname: Margel
mesh_terms: D000230:Adenocarcinoma / Q000378:metabolism* / Q000473:pathology / Q000628:therapy; D000327:Adsorption; D000818:Animals; D001692:Biological Transport; D045744:Cell Line, Tumor; D002642:Chick Embryo; D003110:Colonic Neoplasms / Q000378:metabolism* / Q000473:pathology / Q000628:therapy; D004337:Drug Carriers / Q000138:chemical synthesis* / Q000494:pharmacology; D005456:Fluorescent Dyes; D006801:Humans; D006863:Hydrogen-Ion Concentration; D051379:Mice; D008819:Mice, Nude; D053758:Nanoparticles / Q000737:chemistry* / Q000627:therapeutic use; D055668:Photochemical Processes; D011137:Polystyrenes / Q000737:chemistry*; D012709:Serum Albumin / Q000737:chemistry*; D019265:Spectroscopy, Near-Infrared; D055672:Static Electricity; D013499:Surface Properties
chemical_list: D004337:Drug Carriers; D005456:Fluorescent Dyes; D011137:Polystyrenes; D012709:Serum Albumin