title: Peri-implantitis versus periodontitis: functional differences indicated by transcriptome profiling.
abstract: BACKGROUND
  Periodontitis and Periimplantitis are oftentimes discussed as one entity, which is reflected by therapeutical as well as by scientific approaches. It is unclear, to which extent the similarity of the clinical characteristics is attributed to similarities in the underlying disease mechanisms.
  
  
  OBJECTIVE
  The main objective of the study is to display if or how different periimplantitis and periodontitis are on the mRNA level, representing a high-resolution map of disease-associated events.
  
  
  METHODS
  Aiming to describe the pathophysiological mechanisms in vivo, primary gingival tissue from 7 periimplantitis patients, 7 periodontitis patients and 8 healthy controls was employed in order to generate genome wide transcriptome profiles.
  
  
  RESULTS
  On the basis of quantitative transcriptome analysis, we could show that periimplantitis and periodontitis exhibit significantly different mRNA signatures. Additionally we present a disease associated mRNA profile, which displays potential periimplantitis disease mechanisms. A gene ontology analysis revealed various pathways, supporting the hypothesis of periimplantitis being a complex inflammatory disorder with a unique pathophysiology. While in periimplantitis tissue the regulation of transcripts related to innate immune responses and defense responses were dominating, in periodontitis tissues bacterial response systems prevailed.
  
  
  CONCLUSIONS
  Taken together, our results suggest considering periimplantitis and periodontitis as disease entities with shared as well as with distinct features, which should be reflected on the therapeutical as well as on the scientific level.
authors.affiliation: Department of Oral and Maxillofacial Surgery, Christian-Albrechts University of Kiel, Kiel, Germany.
authors.forename: Stephan T
authors.initials: ST
authors.lastname: Becker
authors.forename: Benedicta E
authors.initials: BE
authors.lastname: Beck-Broichsitter
authors.forename: Christian
authors.initials: C
authors.lastname: Graetz
authors.forename: Christof E
authors.initials: CE
authors.lastname: Dörfer
authors.forename: Jörg
authors.initials: J
authors.lastname: Wiltfang
authors.forename: Robert
authors.initials: R
authors.lastname: Häsler
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D015331:Cohort Studies; D005260:Female; D020869:Gene Expression Profiling; D006801:Humans; D008297:Male; D008875:Middle Aged; D057873:Peri-Implantitis / Q000235:genetics / Q000503:physiopathology*; D010518:Periodontitis / Q000235:genetics / Q000503:physiopathology*; D059467:Transcriptome; D055815:Young Adult