title: The inhibitory effects of representative chalcones contained in Angelica keiskei on melanin biosynthesis in B16 melanoma cells.
abstract: In our effort to find new whitening agents, we evaluated the effects of representative chalcones [4-hydroxyderricin (1), xanthoangelol (2), xanthoangelol H (3), deoxyxanthoangelol H (4), and deoxydihydroxanthoangelol H (5)] contained in the stem of Angelica keiskei on tyrosinase and melanin formation in B16 melanoma cells. In addition, the antioxidant effects of these chalcones in ORAC and DPPH assays were also determined. Interestingly, all chalcones (1-5) inhibit melanin formation in B16 melanoma cells, with low cytotoxicity.
authors.affiliation: Department of Forest Product Technology, Faculty of Forestry, Mulawarman University, Samarinda, 75123, Indonesia.
authors.forename: Enos Tangke
authors.initials: ET
authors.lastname: Arung
authors.forename: Shoko
authors.initials: S
authors.lastname: Furuta
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Sugamoto
authors.forename: Kuniyoshi
authors.initials: K
authors.lastname: Shimizu
authors.forename: Hiroya
authors.initials: H
authors.lastname: Ishikawa
authors.forename: Yoh-ichi
authors.initials: Y
authors.lastname: Matsushita
authors.forename: Ryuichiro
authors.initials: R
authors.lastname: Kondo
mesh_terms: D029969:Angelica / Q000737:chemistry*; D000818:Animals; D045744:Cell Line, Tumor; D047188:Chalcones / Q000737:chemistry* / Q000494:pharmacology*; D008543:Melanins / Q000037:antagonists & inhibitors* / Q000096:biosynthesis*; D015394:Molecular Structure
chemical_list: D047188:Chalcones; D008543:Melanins