title: Plasma adrenomedullin and subclinical cardiorenal syndrome in patients with type 2 diabetes mellitus.
abstract: OBJECTIVE
  To evaluate whether plasma adrenomedullin is involved in the previously reported significant inverse correlation between left ventricular (LV) end-diastolic pressure (peak velocity of early transmitral flow/peak velocity of early diastolic mitral annular motion ratio [E/E' ]) and estimated glomerular filtration rate (eGFR) in patients with type 2 diabetes mellitus, mild-to-moderate renal function impairment and LV relaxation impairment (E'≤7.1 cm/s).
  
  
  METHODS
  Plasma adrenomedullin concentration, E/E' and eGFR were assessed in 82 patients with type 2 diabetes.
  
  
  RESULTS
  Plasma adrenomedullin concentration was positively correlated with eGFR in patients with or without LV relaxation impairment, and inversely correlated with E/E' in patients with LV relaxation impairment. Multivariate linear regression analysis supported a role for plasma adrenomedullin in the association between E/E' and eGFR.
  
  
  CONCLUSIONS
  These results support the hypothesis that adrenomedullin modulates the interaction between the heart and kidneys in early subclinical cardiorenal syndrome in patients with type 2 diabetes mellitus.
authors.affiliation: Department of Medicine, University Hospital Motol, Second Medical School, Charles University, V Úvalu 84, 150 06 Prague 5, Czech Republic. marenkapecka@gmail.com
authors.forename: M
authors.initials: M
authors.lastname: Pecková
authors.forename: J
authors.initials: J
authors.lastname: Charvat
authors.forename: O
authors.initials: O
authors.lastname: Schuck
authors.forename: V
authors.initials: V
authors.lastname: Zamrazil
authors.forename: R
authors.initials: R
authors.lastname: Bilek
authors.forename: M
authors.initials: M
authors.lastname: Hill
authors.forename: P
authors.initials: P
authors.lastname: Svab
authors.forename: M
authors.initials: M
authors.lastname: Horackova
mesh_terms: D053607:Adrenomedullin / Q000097:blood*; D000368:Aged; D059347:Cardio-Renal Syndrome / Q000097:blood* / Q000209:etiology / Q000503:physiopathology; D003924:Diabetes Mellitus, Type 2 / Q000097:blood* / Q000150:complications / Q000503:physiopathology; D005260:Female; D005919:Glomerular Filtration Rate; D006801:Humans; D016014:Linear Models; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D018487:Ventricular Dysfunction, Left / Q000097:blood / Q000209:etiology / Q000503:physiopathology
chemical_list: C507862:ADM protein, human; D053607:Adrenomedullin