title: Chapter 11 Clinical, haematological and biochemical parameters in patients receiving renal replacement therapy in paediatric centres in the UK in 2010: national and centre-specific analyses.
abstract: BACKGROUND
  The British Association for Paediatric Nephrology Registry was established to analyse data related to renal replacement therapy (RRT) for children. The registry receives data from the 13 paediatric nephrology centres in the UK.
  
  
  OBJECTIVE
  To provide centre specific data so that individual centres can reflect on the contribution that their data makes to the national picture and to determine the extent to which their patient parameters meet nationally agreed audit standards for the management of children with established renal failure.
  
  
  METHODS
  Data returns have been a mixture of electronic and paper returns. Data were analysed to calculate summary statistics and where applicable the percentage achieving an audit standard. The standards used were those set out by the Renal Association and the National Institute for Health and Clinical Excellence.
  
  
  RESULTS
  Anthropometric data confirmed that children receiving RRT are short compared to healthy peers. Amongst patients with a height z-score of <2SD between 2000 and 2010, 27% were receiving growth hormone if they were on dialysis compared to 10% if they had a functioning transplant. Blood pressure was higher in children receiving RRT than in healthy children with wide inter-centre variation. The percentage of patients achieving the treatment standards for haemoglobin and ferritin has gradually increased over the last decade, more noticeably in dialysis patients. Analysis by age showed that the proportion of children with a haemoglobin below the standard was greatest for the under 5 years age group irrespective of RRT modality. The control of renal bone disease remained challenging.
  
  
  CONCLUSIONS
  Optimizing growth in children on RRT remains challenging and the control of bone biochemistry in children on dialysis is imperfect. However there is some room for optimism as this year's data shows an improving trend in the control of anaemia and systolic blood pressure.
authors.affiliation: UK Renal Registry, Bristol, UK.
authors.forename: Rishi
authors.initials: R
authors.lastname: Pruthi
authors.forename: Heather
authors.initials: H
authors.lastname: Maxwell
authors.forename: Anna
authors.initials: A
authors.lastname: Casula
authors.forename: Yincent
authors.initials: Y
authors.lastname: Tse
authors.forename: Manish D
authors.initials: MD
authors.lastname: Sinha
authors.forename: Catherine
authors.initials: C
authors.lastname: O'Brien
authors.forename: Malcolm
authors.initials: M
authors.lastname: Lewis
authors.forename: Carol
authors.initials: C
authors.lastname: Inward
mesh_terms: D000293:Adolescent; D000740:Anemia / Q000097:blood / Q000209:etiology / Q000517:prevention & control; D000886:Anthropometry; D001794:Blood Pressure; D002118:Calcium / Q000097:blood; D002391:Catchment Area, Health; D002648:Child; D002675:Child, Preschool; D057286:Electronic Health Records; D005260:Female; D005293:Ferritins / Q000097:blood; D006130:Growth Disorders / Q000188:drug therapy / Q000209:etiology / Q000517:prevention & control; D019983:Guideline Adherence; D006436:Hemodialysis Units, Hospital / Q000706:statistics & numerical data; D006454:Hemoglobins / Q000032:analysis; D019382:Human Growth Hormone / Q000627:therapeutic use; D006801:Humans; D006973:Hypertension / Q000209:etiology / Q000517:prevention & control; D007223:Infant; D007676:Kidney Failure, Chronic / Q000097:blood / Q000453:epidemiology / Q000503:physiopathology / Q000628:therapy*; D008297:Male; D010710:Phosphates / Q000097:blood; D017410:Practice Guidelines as Topic; D012042:Registries / Q000706:statistics & numerical data*; D017582:Renal Replacement Therapy / Q000592:standards / Q000706:statistics & numerical data*; D062606:Tertiary Care Centers / Q000706:statistics & numerical data; D006113:United Kingdom / Q000453:epidemiology
chemical_list: D006454:Hemoglobins; D010710:Phosphates; D019382:Human Growth Hormone; D005293:Ferritins; D002118:Calcium