title: Pathophysiology of aerodigestive pulmonary disorders in the neonate.
abstract: No test can provide a definitive diagnosis of aerodigestive disease. When interpreting tests, one should weigh the benefits and weaknesses of different technologies and methods, scientific appropriateness of the testing conditions, clinicopathologic correlation, and pharmacologic approaches. Gastroesophageal reflux disease (GERD) symptoms and airway symptoms can coexist, and they cannot be distinguished without specific testing and direct observations. Important aerodigestive disorders include dysphagia, GERD, and aggravation of airway injury due to malfunctions of swallowing or airway protection mechanisms. Objective evaluation of aerodigestive reflexes and symptom correlation may provide support for evidence-based personalized management of feeding and airway protection strategies.
authors.affiliation: The Neonatal and Infant Feeding Disorders Program, Center for Perinatal Research, The Research Institute at Nationwide Children's Hospital, The Ohio State University Wexner College of Medicine, 700 Children's Drive, Columbus, OH 43205, USA. sudarshan.jadcherla@nationwidechildrens.org
authors.forename: Sudarshan R
authors.initials: SR
authors.lastname: Jadcherla
mesh_terms: D003680:Deglutition Disorders / Q000503:physiopathology* / Q000628:therapy; D005764:Gastroesophageal Reflux / Q000503:physiopathology* / Q000628:therapy; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature; D008171:Lung Diseases / Q000503:physiopathology* / Q000628:therapy; D012018:Reflex / Q000502:physiology; D012143:Respiratory Physiological Phenomena; D012137:Respiratory System / Q000033:anatomy & histology; D041742:Upper Gastrointestinal Tract / Q000033:anatomy & histology / Q000502:physiology