title: Corneal angiogenesis and lymphangiogenesis.
abstract: OBJECTIVE
  The purpose of the present review is to describe new antilymphangiogenic treatment strategies and recent findings on strain-dependency of corneal lymphangiogenesis and the interdependency between blood and lymphatic vessel growth.
  
  
  RESULTS
  Studies on mice have revealed that apart from haemangiogenesis, lymphangiogenesis can also differ markedly between several mouse strains under normal and inflammatory conditions. Although haemangiogenesis and lymphangiogenesis are closely interconnected in their spatial-temporal patterning, recent data suggest that they can also occur independently.
  
  
  CONCLUSIONS
  Understanding the coordinated regulation of blood and lymphatic vessel growth and genetic factors determining lymphangiogenesis in more detail could improve the development of specifically targeted antihaemangiogenic or antilymphangiogenic strategies.
authors.affiliation: Department of Ophthalmology, University Hospital of Cologne, Cologne, Germany.
authors.forename: Birgit
authors.initials: B
authors.lastname: Regenfuss
authors.forename: Felix
authors.initials: F
authors.lastname: Bock
authors.forename: Claus
authors.initials: C
authors.lastname: Cursiefen
mesh_terms: D000818:Animals; D016510:Corneal Neovascularization / Q000235:genetics / Q000503:physiopathology; D004195:Disease Models, Animal; D018740:Genetic Heterogeneity; D006801:Humans; D042583:Lymphangiogenesis / Q000235:genetics / Q000502:physiology; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL