title: Cholinergic receptor exocytosis under conditions of depression of acetylcholine-induced current in edible snail neurons in cellular analogue of habituation.
abstract: Exocytosis inhibitor Exo 1 potentiates depression of acetylcholine-induced inward current in defensive behavior command neurons of edible snail, when acetylcholine is applied rhythmically to the soma in cellular correlate of habituation. A mathematical model presupposing different receptor localization in the cell and regularities of their translocations made it possible to analyze the dependence of acetylcholine-induced current depression on a number of intracellular processes. It was concluded that depression of choline-sensitive extrasynaptic zones on the membrane of defensive behavior command neurons in edible snail in cellular correlate of habituation is partially determined by attenuation of exocytosis of internalized cholinergic receptors.
authors.affiliation: Department of Higher Nervous Activity, M. V. Lomonosov Moscow State University, Moscow, Russia.
authors.forename: D A
authors.initials: DA
authors.lastname: Makhnovskiy
authors.forename: G B
authors.initials: GB
authors.lastname: Murzina
authors.forename: A S
authors.initials: AS
authors.lastname: Pivovarov
mesh_terms: D000109:Acetylcholine / Q000008:administration & dosage / Q000494:pharmacology; D000818:Animals; D001549:Benzamides / Q000008:administration & dosage / Q000494:pharmacology; D001565:Benzoates / Q000008:administration & dosage / Q000494:pharmacology; D059329:Cholinergic Neurons / Q000187:drug effects / Q000502:physiology*; D004121:Dimethyl Sulfoxide; D005089:Exocytosis / Q000502:physiology*; D006185:Habituation, Psychophysiologic / Q000187:drug effects / Q000502:physiology*; D006372:Helix, Snails / Q000502:physiology*; D008564:Membrane Potentials / Q000187:drug effects*; D008959:Models, Neurological; D011950:Receptors, Cholinergic / Q000378:metabolism*
chemical_list: C568977:2-(4-fluorobenzoylamino)benzoic acid methyl ester; D001549:Benzamides; D001565:Benzoates; D011950:Receptors, Cholinergic; D000109:Acetylcholine; D004121:Dimethyl Sulfoxide