title: The association between levels of tissue inhibitor of metalloproteinase-1 with acute heart failure and left ventricular dysfunction in patients with ST elevation myocardial infarction treated by primary percutaneous coronary intervention.
abstract: OBJECTIVE
  Tissue inhibitors of metalloproteinase (TIMPs) bind to active matrix metalloproteinase (MMPs), and thereby inhibit their proteolytic activity. We investigated the role of polymorphisms in the gene for TIMP-1 and serum levels of TIMP-1 in association with postmyocardial infarction (MI), left ventricular (LV) dysfunction, and symptoms of acute heart failure (AHF) in patients treated with primary percutaneous coronary intervention.
  
  
  METHODS
  In total, 556 patients with STEMI were evaluated. Levels of TIMP-1 were measured at admission and 24 h after MI onset. The TIMP-1 exon 5 SNP rs4898 (F124F with T>C) located at X chromosome was assayed.
  
  
  RESULTS
  TIMP-1 levels were higher for men with AHF as well as for men with LV dysfunction (ejection fraction [EF]<40%). According to multivariate analysis, the TIMP-1 level was a factor with an independent negative relationship to EF and AHF in men. An independent relationship between exon 5 TIMP-1 gene polymorphism and EF, AHF or TIMP-1 level was not documented.
  
  
  CONCLUSIONS
  These results provide evidence that a higher level of circulating TIMP-1 is independently associated with worse EF and AHF.
authors.affiliation: Institute of Pathological Physiology, Masaryk University, Brno, Czech Republic.
authors.forename: Monika Pavkova
authors.initials: MP
authors.lastname: Goldbergova
authors.forename: Jiri
authors.initials: J
authors.lastname: Parenica
authors.forename: Jiri
authors.initials: J
authors.lastname: Jarkovsky
authors.forename: Petr
authors.initials: P
authors.lastname: Kala
authors.forename: Martin
authors.initials: M
authors.lastname: Poloczek
authors.forename: Jan
authors.initials: J
authors.lastname: Manousek
authors.forename: Krystyna
authors.initials: K
authors.lastname: Kluz
authors.forename: Lenka
authors.initials: L
authors.lastname: Kubkova
authors.forename: Simona
authors.initials: S
authors.lastname: Littnerova
authors.forename: Martin
authors.initials: M
authors.lastname: Tesak
authors.forename: Ondrej
authors.initials: O
authors.lastname: Toman
authors.forename: Nikolas
authors.initials: N
authors.lastname: Pavek
authors.forename: Zdenka
authors.initials: Z
authors.lastname: Cermakova
authors.forename: Josef
authors.initials: J
authors.lastname: Tomandl
authors.forename: Anna
authors.initials: A
authors.lastname: Vasku
authors.forename: Jindrich
authors.initials: J
authors.lastname: Spinar
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D006333:Heart Failure / Q000097:blood* / Q000235:genetics; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000097:blood* / Q000235:genetics / Q000628:therapy*; D062645:Percutaneous Coronary Intervention / Q000379:methods*; D011110:Polymorphism, Genetic; D019715:Tissue Inhibitor of Metalloproteinase-1 / Q000097:blood* / Q000235:genetics; D018487:Ventricular Dysfunction, Left / Q000097:blood* / Q000235:genetics
chemical_list: C560822:TIMP1 protein, human; D019715:Tissue Inhibitor of Metalloproteinase-1