title: Presentation of two patients with malignant granulosa cell tumors, with a review of the literature.
abstract: Granulosa cell tumors (GCTs) of the ovary account for 2 to 5 of ovarian malignancies. We present two patients with malignant ovarian adult GCT. In one patient, a combination of bleomycin, etoposide, and cisplatin was effective after initial surgery for malignant GCT. In the other, an aromatase inhibitor was effective for recurrent malignant GCT. We also review the literature for further management of this tumor. Because GCT of the ovary is rare, it will be necessary to elucidate the clinical phenotype and establish treatment protocols by accumulating and analyzing more patients.
authors.affiliation: Department of Obstetrics and Gynecology, Hirosaki University Graduate School of Medicine, 5-Zaifu-cho, Hirosaki, Japan.
authors.forename: Ryousuke
authors.initials: R
authors.lastname: Tamura
authors.forename: Yoshihito
authors.initials: Y
authors.lastname: Yokoyama
authors.forename: Takeshi
authors.initials: T
authors.lastname: Yanagita
authors.forename: Yukiko
authors.initials: Y
authors.lastname: Matsumura
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Abe
authors.forename: Ryousuke
authors.initials: R
authors.lastname: Taniguchi
authors.forename: Hideki
authors.initials: H
authors.lastname: Mizunuma
mesh_terms: D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D001761:Bleomycin / Q000008:administration & dosage; D002945:Cisplatin / Q000008:administration & dosage; D003131:Combined Modality Therapy; D005047:Etoposide / Q000008:administration & dosage; D005260:Female; D006106:Granulosa Cell Tumor / Q000473:pathology* / Q000628:therapy; D006801:Humans; D008197:Lymph Node Excision; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000473:pathology* / Q000628:therapy; D010051:Ovarian Neoplasms / Q000473:pathology* / Q000628:therapy; D012196:Review Literature as Topic; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome
chemical_list: D001761:Bleomycin; D005047:Etoposide; D002945:Cisplatin