title: Use of Integra and interval brachytherapy in a 2-stage auricular reconstruction after excision of a recurrent keloid.
abstract: Keloids present a formidable clinical challenge. Surgical excision in conjunction with radiation therapy may decrease the chance of keloid recurrence. Split-thickness skin grafts, however, are more prone to failure in the setting of radiation. In this report, we present a patient with a recurrent auricular keloid who underwent excision and immediate Integra (Integra LifeSciences, Plainsboro, NJ) application, followed by high-dose rate brachytherapy and interval split-thickness skin graft placement. A 23-year-old woman with a history of a recurrent auricular keloid after previous surgical excision, corticosteroid injection, and radiation underwent reexcision of her keloid. Integra was used to cover the resultant exposed auricular perichondrium. The patient then received high-dose rate brachytherapy (1500 cGy) on postoperative days 1 and 2, followed by definitive split-thickness skin graft placement 3 weeks after her initial surgery. The patient recovered from all interventions without complication. There was no evidence of keloid formation 27 months after the interval split-thickness skin graft placement at either the auricular recipient or thigh donor sites. We report the first case of a 2-stage reconstruction of a recurrent auricular keloid (composed of keloid excision and placement of Integra in conjunction with high-dose rate brachytherapy, followed by interval split-thickness skin grafting), resulting in an acceptable cosmetic result without evidence of recurrence at long-term follow-up.
authors.affiliation: Division of Plastic Surgery, Weill Cornell Medical College, New York, NY 10065, USA.
authors.forename: Alyssa J
authors.initials: AJ
authors.lastname: Reiffel
authors.forename: Allie M
authors.initials: AM
authors.lastname: Sohn
authors.forename: Peter W
authors.initials: PW
authors.lastname: Henderson
authors.forename: Natalia
authors.initials: N
authors.lastname: Fullerton
authors.forename: Jason A
authors.initials: JA
authors.lastname: Spector
mesh_terms: D001918:Brachytherapy / Q000379:methods*; D004431:Ear, External; D005260:Female; D006801:Humans; D007627:Keloid / Q000532:radiotherapy* / Q000601:surgery*; D011879:Radiotherapy Dosage; D012008:Recurrence; D016038:Skin Transplantation / Q000379:methods*; D013848:Thigh; D055815:Young Adult