title: Reducing adverse effects of proton pump inhibitors.
abstract: Proton pump inhibitors effectively treat gastroesophageal reflux disease, erosive esophagitis, duodenal ulcers, and pathologic hypersecretory conditions. Proton pump inhibitors cause few adverse effects with short-term use; however, long-term use has been scrutinized for appropriateness, drug-drug interactions, and the potential for adverse effects (e.g., hip fractures, cardiac events, iron deficiency, Clostridium difficile infection, pneumonia). Adults 65 years and older are more vulnerable to these adverse effects because of the higher prevalence of chronic diseases in this population. Proton pump inhibitors administered for stress ulcer prophylaxis should be discontinued after the patient is discharged from the intensive care unit unless other indications exist.
authors.affiliation: Excela Health Latrobe Family Medicine Residency Program, Latrobe, PA, USA. pament@excelahealth.org
authors.forename: Paul W
authors.initials: PW
authors.lastname: Ament
authors.forename: Daniel B
authors.initials: DB
authors.lastname: Dicola
authors.forename: Mary E
authors.initials: ME
authors.lastname: James
mesh_terms: D018798:Anemia, Iron-Deficiency / Q000150:complications; D000077144:Clopidogrel; D016360:Clostridioides difficile; D003422:Critical Care; D003967:Diarrhea / Q000209:etiology; D004347:Drug Interactions; D004761:Enterocolitis, Pseudomembranous / Q000150:complications; D005764:Gastroesophageal Reflux / Q000628:therapy; D006471:Gastrointestinal Hemorrhage / Q000139:chemically induced; D006620:Hip Fractures / Q000139:chemically induced; D006801:Humans; D009203:Myocardial Infarction / Q000517:prevention & control; D010975:Platelet Aggregation Inhibitors / Q000009:adverse effects; D011014:Pneumonia / Q000139:chemically induced; D054328:Proton Pump Inhibitors / Q000009:adverse effects*; D012008:Recurrence; D012307:Risk Factors; D013276:Stomach Ulcer / Q000628:therapy; D013312:Stress, Physiological / Q000502:physiology; D013988:Ticlopidine / Q000009:adverse effects / Q000031:analogs & derivatives; D014456:Ulcer / Q000503:physiopathology / Q000517:prevention & control
chemical_list: D010975:Platelet Aggregation Inhibitors; D054328:Proton Pump Inhibitors; D000077144:Clopidogrel; D013988:Ticlopidine