title: An efficient labeling strategy of drug like molecules with functionalized alkyl linkers using CH-activation.
abstract: Heterocyclic drugs can be cross-coupled with functionalized thiophene derivatives under dehydrogenative conditions using Pd-catalysts. Upon reductive desulfurization an alkyl linker is introduced with a functional group at its terminus, which will allow the immobilization of the drug molecule onto a solid support for chemical proteomics.
authors.affiliation: Institute of Organic Chemistry, Graz University of Technology, Graz 8010, Austria.
authors.forename: Jana
authors.initials: J
authors.lastname: Rentner
authors.forename: Rolf
authors.initials: R
authors.lastname: Breinbauer
mesh_terms: D002384:Catalysis; D006571:Heterocyclic Compounds / Q000138:chemical synthesis / Q000737:chemistry*; D010165:Palladium / Q000737:chemistry; D004364:Pharmaceutical Preparations / Q000138:chemical synthesis / Q000737:chemistry*; D040901:Proteomics; D013194:Staining and Labeling; D013876:Thiophenes / Q000737:chemistry*
chemical_list: D006571:Heterocyclic Compounds; D004364:Pharmaceutical Preparations; D013876:Thiophenes; D010165:Palladium