title: Unusual presentation of sarcoid-like reaction on bone marrow level associated with mediastinal lymphadenopathy on (18)F-FDG-PET/CT resembling an early recurrence of Hodgkin's Lymphoma.
abstract: (18)F-FDG-PET/CT is widely employed to evaluate lymphoma patients. False positive results are quite frequent, generally due to active phase of inflammation. We describe an unusual PET/CT presentation of a sarcoid-like reaction (SLR) in a patient monitored for Hodgkin Lymphoma characterized by an intense uptake in lymph nodes and multiple bone foci in a PET/CT study. The final diagnosis was obtained by biopsy. This study draws attention to the fact that multifocal bone marrow uptakes due to a sarcoideal reaction may be a possible cause of false positive results in (18)F-FDG-PET/CT studies in oncology patients.
authors.affiliation: Nuclear Medicine Department, San Raffaele Scientific Institute, Milan, Italy.
authors.forename: F
authors.initials: F
authors.lastname: Fallanca
authors.forename: M
authors.initials: M
authors.lastname: Picchio
authors.forename: C
authors.initials: C
authors.lastname: Crivellaro
authors.forename: P
authors.initials: P
authors.lastname: Mapelli
authors.forename: A M
authors.initials: AM
authors.lastname: Samanes Gajate
authors.forename: E
authors.initials: E
authors.lastname: Sabattini
authors.forename: L
authors.initials: L
authors.lastname: Gianolli
authors.forename: C
authors.initials: C
authors.lastname: Messa
mesh_terms: D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D001761:Bleomycin / Q000008:administration & dosage; D001847:Bone Diseases / Q000000981:diagnostic imaging* / Q000473:pathology; D001853:Bone Marrow / Q000000981:diagnostic imaging* / Q000473:pathology; D003131:Combined Modality Therapy; D003606:Dacarbazine / Q000008:administration & dosage; D003841:Deoxycytidine / Q000008:administration & dosage / Q000031:analogs & derivatives; D003937:Diagnosis, Differential; D004317:Doxorubicin / Q000008:administration & dosage; D005189:False Positive Reactions; D005260:Female; D005462:Fluorine Radioisotopes; D019788:Fluorodeoxyglucose F18; D006099:Granuloma / Q000000981:diagnostic imaging* / Q000473:pathology; D006689:Hodgkin Disease / Q000000981:diagnostic imaging* / Q000188:drug therapy / Q000532:radiotherapy / Q000601:surgery; D006801:Humans; D007069:Ifosfamide / Q000008:administration & dosage; D008198:Lymph Nodes / Q000000981:diagnostic imaging* / Q000473:pathology; D008482:Mediastinum / Q000000981:diagnostic imaging* / Q000473:pathology; D064847:Multimodal Imaging; D036102:Peripheral Blood Stem Cell Transplantation; D049268:Positron-Emission Tomography; D011241:Prednisone / Q000008:administration & dosage; D019275:Radiopharmaceuticals; D012008:Recurrence; D012074:Remission Induction; D012507:Sarcoidosis / Q000175:diagnosis; D014057:Tomography, X-Ray Computed; D014182:Transplantation, Autologous; D014747:Vinblastine / Q000008:administration & dosage / Q000031:analogs & derivatives; D000077235:Vinorelbine; D000093542:Gemcitabine
chemical_list: D005462:Fluorine Radioisotopes; D019275:Radiopharmaceuticals; D003841:Deoxycytidine; D019788:Fluorodeoxyglucose F18; D001761:Bleomycin; D014747:Vinblastine; D003606:Dacarbazine; D004317:Doxorubicin; D000077235:Vinorelbine; D007069:Ifosfamide; D011241:Prednisone; D000093542:Gemcitabine