title: DNA methylation inhibitors in cancer: recent and future approaches.
abstract: This review presents the different human DNA methyltransferases (DNMTs), their biological roles, their mechanisms of action and their role in cancer. The description of assays for detecting DNMT inhibitors (DNMTi) follows. The different known DNMTi are reported along with their advantages, drawbacks and clinical trials. A discussion on the features of the future DNMT inhibitors will conclude this review.
authors.affiliation: USR CNRS-Pierre Fabre n° 3388-ETaC Epigenetic Targeting of Cancer, CRDPF 3 avenue Hubert Curien, 31035 Toulouse Cedex 01, France.
authors.forename: Christina
authors.initials: C
authors.lastname: Gros
authors.forename: Jacques
authors.initials: J
authors.lastname: Fahy
authors.forename: Ludovic
authors.initials: L
authors.lastname: Halby
authors.forename: Isabelle
authors.initials: I
authors.lastname: Dufau
authors.forename: Alexandre
authors.initials: A
authors.lastname: Erdmann
authors.forename: Jean-Marc
authors.initials: JM
authors.lastname: Gregoire
authors.forename: Fréderic
authors.initials: F
authors.lastname: Ausseil
authors.forename: Stéphane
authors.initials: S
authors.lastname: Vispé
authors.forename: Paola B
authors.initials: PB
authors.lastname: Arimondo
mesh_terms: D000818:Animals; D004248:DNA (Cytosine-5-)-Methyltransferases / Q000037:antagonists & inhibitors / Q000378:metabolism; D019175:DNA Methylation / Q000187:drug effects*; D004791:Enzyme Inhibitors / Q000494:pharmacology / Q000627:therapeutic use; D006801:Humans; D009369:Neoplasms / Q000188:drug therapy / Q000201:enzymology / Q000235:genetics*
chemical_list: D004791:Enzyme Inhibitors; D004248:DNA (Cytosine-5-)-Methyltransferases