title: Relation of sensory peripheral neuropathy in Sjögren syndrome to anti-Ro/SSA.
abstract: BACKGROUND
  Sjögren syndrome is a common, chronic autoimmune disease that typically produces inflammation and poor function of the salivary and lacrimal glands. Other organs can be affected, including the nervous system. Sensory peripheral neuropathy is a common manifestation of the disease.
  
  
  METHODS
  Eight-eight patients attending a dry eyes-dry mouth clinic were diagnosed to have primary Sjögren syndrome and underwent a neurological examination. Anti-Ro (or SSA) and anti-La (or SSB) were determined using immunodiffusion as well as Inno-Lia and BioPlex ANA screen. Serum vitamin B(12) levels were determined using an enzyme-linked microtiter plate assay.
  
  
  RESULTS
  Twenty-seven (31%) of the 88 patients had peripheral neuropathy as defined by loss of light touch, proprioception, or vibratory sensation. Anti-Ro and anti-La were found by immunodiffusion in 12 patients, and 8 of these 12 had neuropathy (χ(2) = 8.46, P = 0.0036, odds ratio = 6.0 compared to those without precipitating anti-Ro and anti-La). Of the 27 patients with only anti-Ro by immunodiffusion, 13 (48.1%) had neuropathy (χ(2) = 5.587, P = 0.018, compared to those without anti-Ro). There was no relationship of the other, more sensitive measures of anti-Ro and anti-La to neuropathy. In addition, we found no association of serum vitamin B(12) levels to neuropathy among these patients with Sjögren syndrome.
  
  
  CONCLUSIONS
  Sensory peripheral neuropathy is common among patients with Sjögren syndrome and is associated with the presence of anti-Ro and anti-La when determined by immunodiffusion.
authors.affiliation: Arthritis & Clinical Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, USA.
authors.forename: Amanda Kyle
authors.initials: AK
authors.lastname: Scofield
authors.forename: Lida
authors.initials: L
authors.lastname: Radfar
authors.forename: John A
authors.initials: JA
authors.lastname: Ice
authors.forename: Evan
authors.initials: E
authors.lastname: Vista
authors.forename: Juan-Manuel
authors.initials: JM
authors.lastname: Anaya
authors.forename: Glen
authors.initials: G
authors.lastname: Houston
authors.forename: David
authors.initials: D
authors.lastname: Lewis
authors.forename: Donald U
authors.initials: DU
authors.lastname: Stone
authors.forename: James
authors.initials: J
authors.lastname: Chodosh
authors.forename: Kimberly
authors.initials: K
authors.lastname: Hefner
authors.forename: Christopher J
authors.initials: CJ
authors.lastname: Lessard
authors.forename: Kathy L
authors.initials: KL
authors.lastname: Moser
authors.forename: Robert Hal
authors.initials: RH
authors.lastname: Scofield
mesh_terms: D000328:Adult; D000368:Aged; D000974:Antibodies, Antinuclear / Q000097:blood*; D001324:Autoantigens / Q000097:blood*; D015331:Cohort Studies; D005260:Female; D006801:Humans; D005779:Immunodiffusion; D008297:Male; D008875:Middle Aged; D010523:Peripheral Nervous System Diseases / Q000209:etiology / Q000276:immunology*; D012261:Ribonucleoproteins / Q000097:blood*; D012859:Sjogren's Syndrome / Q000150:complications / Q000276:immunology*; D014805:Vitamin B 12 / Q000097:blood; D000097585:SS-B Antigen; D000099207:SS-A Antigen
chemical_list: D000974:Antibodies, Antinuclear; D001324:Autoantigens; D012261:Ribonucleoproteins; D014805:Vitamin B 12; D000097585:SS-B Antigen; D000099207:SS-A Antigen