title: New alkaloids from Lycopodium japonicum.
abstract: Three new alkaloids (1-3), together with ten known alkaloids, were isolated from the ethanolic extract of the whole plants of Lycopodium japonicum THUNB. Their structures were elucidated on the basis of spectroscopic analysis, including MS and NMR methods. All alkaloids isolated were assayed for cytotoxic activity against four human cancer cell lines and acetylcholinesterase (AChE) inhibitory activity. No alkaloid showed either cytotoxic activity against four human cancer cell lines or AChE inhibitory activity.
authors.affiliation: Shanghai Institute of Pharmaceutical Industry, China State Institute of Pharmaceutical Industry, Shanghai 200040, P R China.
authors.forename: Bo
authors.initials: B
authors.lastname: Li
authors.forename: Wei-Dong
authors.initials: WD
authors.lastname: Zhang
authors.forename: Yi-Ren
authors.initials: YR
authors.lastname: He
authors.forename: Lu
authors.initials: L
authors.lastname: Lu
authors.forename: De-Yun
authors.initials: DY
authors.lastname: Kong
authors.forename: Yun-Heng
authors.initials: YH
authors.lastname: Shen
mesh_terms: D000110:Acetylcholinesterase / Q000378:metabolism; D000470:Alkaloids / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D045744:Cell Line, Tumor; D002800:Cholinesterase Inhibitors / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D006801:Humans; D032502:Lycopodium / Q000737:chemistry*; D009369:Neoplasms / Q000188:drug therapy
chemical_list: D000470:Alkaloids; D000972:Antineoplastic Agents, Phytogenic; D002800:Cholinesterase Inhibitors; D000110:Acetylcholinesterase