title: In vivo photoacoustic therapy with cancer-targeted indocyanine green-containing nanoparticles.
abstract: OBJECTIVE
  The objective of this work was to study the photoacoustic effect of a special nanoparticle for selective cancer cell killing both in vitro and in vivo.
  
  
  METHODS
  The nanoparticles (NPs) consisting of indocyanine green (ICG), phospholipid-polyethylene glycol (PL-PEG) and folic acid (FA) were used as cancer-targeting nanoprobes. Cancer cells incubated with the ICG-PL-PEG-FA solution were exposed to laser pulses. Finally, tumors in mice were treated with photoacoustic technique.
  
  
  RESULTS
  High selectivity of the photoacoustic destruction of cancer cells was observed. The tumors in mice after photoacoustic treatment showed a much slower growth rate.
  
  
  CONCLUSIONS
  The destruction of the cells was due to the photoacoustic effect originating from the NPs. The ICG-PL-PEG NP-based photoacoustic therapy would be a safe and highly efficient cancer treatment technique.
authors.affiliation: MOE Key Laboratory of Laser Life Science & Institute of Laser Life Science, College of Biophotonics, South China Normal University, Guangzhou 510631, China.
authors.forename: Junping
authors.initials: J
authors.lastname: Zhong
authors.forename: Sihua
authors.initials: S
authors.lastname: Yang
authors.forename: Xiaohui
authors.initials: X
authors.lastname: Zheng
authors.forename: Ting
authors.initials: T
authors.lastname: Zhou
authors.forename: Da
authors.initials: D
authors.lastname: Xing
mesh_terms: D000818:Animals; D001940:Breast / Q000473:pathology; D001943:Breast Neoplasms / Q000473:pathology / Q000628:therapy*; D045744:Cell Line, Tumor; D004396:Coloring Agents / Q000493:pharmacokinetics / Q000627:therapeutic use*; D005260:Female; D005492:Folic Acid / Q000493:pharmacokinetics / Q000627:therapeutic use; D007208:Indocyanine Green / Q000493:pharmacokinetics / Q000627:therapeutic use*; D053685:Laser Therapy / Q000379:methods; D051379:Mice; D008807:Mice, Inbred BALB C; D053758:Nanoparticles / Q000032:analysis / Q000627:therapeutic use*; D010743:Phospholipids / Q000493:pharmacokinetics / Q000627:therapeutic use; D061088:Photoacoustic Techniques / Q000379:methods*; D011092:Polyethylene Glycols / Q000493:pharmacokinetics / Q000627:therapeutic use
chemical_list: D004396:Coloring Agents; D010743:Phospholipids; D011092:Polyethylene Glycols; D005492:Folic Acid; D007208:Indocyanine Green