title: [Shifts in the mice blood-forming system and energy exchange of erythrocytes due to chronic exposure to chemical agents (acetone, ethanol, acetaldehyde) and radiation in concentrations and doses modeling the conditions in extended orbital mission].
abstract: The paper presents the results of an investigation with mice subjected to isolated and successive exposure to a blend of chemical agents (acetone, ethanol, acetaldehyde) at MPC levels defined for piloted space vehicles followed by fractionated gamma-irradiation by daily 1 cGy (30 cGy total). The selected chemicals are the primary contributors to total air contamination and present in the prioritized list of compounds to be monitored to ensure air quality on piloted space vehicles. Radiation levels were determined with allowance for mice radiosensitivity to simulate the actual absorbed dose accumulated by crewmembers of orbital mission of up to a year in duration (10 cGy). Based on the findings in the hematopoietic system and erythrocyte biochemistry, energy exchange and redox parameters, pre-irradiation exposure to chemical agents within the MPC limits accentuated radiosensitivity gravely and, therefore, made mouse organism less tolerant to radiation. It was shown that adaptation of the hematopoietic system calls forth activation and significant straining of regulatory mechanisms equally in opposing to a single factor or combination of chemical and radiation exposure. The marked tension of these mechanisms persisted till day 30 of recovery.
mesh_terms: D000079:Acetaldehyde / Q000008:administration & dosage / Q000633:toxicity*; D000096:Acetone / Q000008:administration & dosage / Q000633:toxicity*; D000393:Air Pollutants / Q000633:toxicity; D000818:Animals; D004784:Environmental Monitoring / Q000379:methods; D004912:Erythrocytes / Q000187:drug effects* / Q000528:radiation effects; D000431:Ethanol / Q000008:administration & dosage / Q000633:toxicity*; D005720:Gamma Rays / Q000009:adverse effects*; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D010084:Oxidation-Reduction; D013026:Space Flight; D013997:Time Factors
chemical_list: D000393:Air Pollutants; D000096:Acetone; D000431:Ethanol; D000079:Acetaldehyde