title: Histidine based fluorescence sensor detects Hg2+ in solution, paper strips, and in cells.
abstract: A chemosensor having a bipodal thiocarbamate scaffold attached to histidine moieties senses Hg(2+) with a remarkable selectivity. The binding results in a 50 nm blue shift in the fluorescence spectra and a 19-fold enhancement of the fluorescence quantum yield of the ligand. In addition to the detection of Hg(2+) visually under UV light in solution, the chemosensor was used for fabrication of paper strips that detected Hg(2+) in aqueous samples. The sensor was also used for imaging Hg(2+) in adult zebrafish and in human epithelial carcinoma HeLa S3 cells.
authors.affiliation: Department of Chemical Sciences, Indian Institute of Science Education and Research Kolkata, BCKV Campus PO, Mohanpur, Nadia, WB 741252, India.
authors.forename: Joydev
authors.initials: J
authors.lastname: Hatai
authors.forename: Suman
authors.initials: S
authors.lastname: Pal
authors.forename: Gregor P
authors.initials: GP
authors.lastname: Jose
authors.forename: Subhajit
authors.initials: S
authors.lastname: Bandyopadhyay
mesh_terms: D000818:Animals; D002413:Cations, Divalent / Q000032:analysis; D005456:Fluorescent Dyes / Q000737:chemistry*; D006367:HeLa Cells; D006639:Histidine / Q000031:analogs & derivatives*; D006801:Humans; D008628:Mercury / Q000032:analysis*; D008856:Microscopy, Fluorescence / Q000379:methods; D010209:Paper; D012680:Sensitivity and Specificity; D013050:Spectrometry, Fluorescence / Q000379:methods*; D014867:Water / Q000032:analysis; D051598:Whole Body Imaging / Q000379:methods; D015027:Zebrafish
chemical_list: D002413:Cations, Divalent; D005456:Fluorescent Dyes; D014867:Water; D006639:Histidine; D008628:Mercury