title: Solving the convergence problem in the synthesis of triantennary N-glycan relevant to prostate-specific membrane antigen (PSMA).
abstract: The first total synthesis of triantennary, fully sialylated N-glycan of complex type is described. Two strategies for installation of sialylated antennae are explored, and both approaches converge on a global glycosylation step that delivers the desired tetradecasaccharide in good yields.
authors.affiliation: Laboratory for Bioorganic Chemistry, Sloan-Kettering Institute for Cancer Research, 1275 York Avenue, New York, New York 10065, USA.
authors.forename: Maciej A
authors.initials: MA
authors.lastname: Walczak
authors.forename: Samuel J
authors.initials: SJ
authors.lastname: Danishefsky
mesh_terms: D000954:Antigens, Surface / Q000276:immunology / Q000378:metabolism*; D019496:Cancer Vaccines / Q000276:immunology / Q000378:metabolism; D060326:Chemistry Techniques, Synthetic; D043425:Glutamate Carboxypeptidase II / Q000276:immunology / Q000378:metabolism*; D006031:Glycosylation; D008358:Mannose / Q000737:chemistry; D011134:Polysaccharides / Q000138:chemical synthesis* / Q000737:chemistry / Q000378:metabolism*
chemical_list: D000954:Antigens, Surface; D019496:Cancer Vaccines; D011134:Polysaccharides; C473848:FOLH1 protein, human; D043425:Glutamate Carboxypeptidase II; D008358:Mannose