title: Monoamine oxidase inhibitors and neuroprotection:  a review.
abstract: Monoamine oxidase inhibitors have been available for more than 50 years, initially developed as antidepressants but currently used in a variety of psychiatric and neurological conditions. There has been a recent surge of interest in monoamine oxidase inhibitors because of their reported neuroprotective and/or neurorescue properties. Interestingly, it seems that often these properties are independent of their ability to inhibit monoamine oxidase. This review article presents an overview of the neuroprotective/neurorescue properties of these multifaceted drugs and focuses on phenelzine, (-)-deprenyl, rasagiline, ladostigil, tranylcypromine, moclobemide, and clorgyline and their possible neuroprotective mechanisms.
authors.affiliation: Neurochemical Research Unit, Department of Psychiatry, University of Alberta, Edmonton, Alberta, Canada.
authors.forename: Saleem K
authors.initials: SK
authors.lastname: Al-Nuaimi
authors.forename: Erin M
authors.initials: EM
authors.lastname: Mackenzie
authors.forename: Glen B
authors.initials: GB
authors.lastname: Baker
mesh_terms: D000818:Animals; D000928:Antidepressive Agents / Q000494:pharmacology / Q000627:therapeutic use; D006801:Humans; D001523:Mental Disorders / Q000188:drug therapy / Q000503:physiopathology; D008996:Monoamine Oxidase Inhibitors / Q000494:pharmacology / Q000627:therapeutic use*; D009422:Nervous System Diseases / Q000188:drug therapy* / Q000503:physiopathology; D018696:Neuroprotective Agents / Q000494:pharmacology / Q000627:therapeutic use*
chemical_list: D000928:Antidepressive Agents; D008996:Monoamine Oxidase Inhibitors; D018696:Neuroprotective Agents