title: Anti-ATP synthase autoantibodies induce neuronal death by apoptosis and impair cognitive performance in C57BL/6J mice.
abstract: Previous studies have suggested a pathogenetic role of autoantibodies (Abs) against ATP synthase (ATPs) in patients with Alzheimer's disease (AD). Using a mouse model, we found that intracerebroventricular administration of anti-ATPs-Abs, purified from AD patients, leads to poor cognitive performance and pronounced cell damage in the hippocampus, a brain region specifically involved in learning and memory processes, which is severely affected in AD. Our results are suggestive of a role of anti-ATPs-Abs in the onset and progression of AD and also provide a fruitful model for the study of memory disturbances in neurodegenerative diseases.
authors.affiliation: Department of Cell Biology and Neurosciences, Istituto Superiore di Sanità, Rome, Italy.
authors.forename: Alessandra
authors.initials: A
authors.lastname: Berry
authors.forename: Davide
authors.initials: D
authors.lastname: Vacirca
authors.forename: Sara
authors.initials: S
authors.lastname: Capoccia
authors.forename: Veronica
authors.initials: V
authors.lastname: Bellisario
authors.forename: Walter
authors.initials: W
authors.lastname: Malorni
authors.forename: Elena
authors.initials: E
authors.lastname: Ortona
authors.forename: Francesca
authors.initials: F
authors.lastname: Cirulli
mesh_terms: D000818:Animals; D000910:Antibodies, Heterophile / Q000276:immunology / Q000494:pharmacology; D017209:Apoptosis / Q000276:immunology*; D001323:Autoantibodies / Q000276:immunology* / Q000494:pharmacology; D003071:Cognition / Q000502:physiology; D003072:Cognition Disorders / Q000276:immunology* / Q000473:pathology; D004195:Disease Models, Animal; D018450:Disease Progression; D006624:Hippocampus / Q000276:immunology / Q000473:pathology; D006801:Humans; D007276:Injections, Intraventricular; D008297:Male; D018782:Maze Learning / Q000502:physiology; D008569:Memory Disorders / Q000276:immunology / Q000473:pathology; D051379:Mice; D008810:Mice, Inbred C57BL; D008928:Mitochondria / Q000276:immunology / Q000473:pathology; D025261:Mitochondrial Proton-Translocating ATPases / Q000037:antagonists & inhibitors* / Q000276:immunology*; D019636:Neurodegenerative Diseases / Q000276:immunology / Q000473:pathology; D009474:Neurons / Q000276:immunology* / Q000473:pathology
chemical_list: D000910:Antibodies, Heterophile; D001323:Autoantibodies; D025261:Mitochondrial Proton-Translocating ATPases