title: Nanosized tamoxifen-porphyrin-glucose [TPG] conjugate: novel selective anti-breast-cancer agent, synthesis and in vitro evaluations.
abstract: Tumor and especially breast cancer is among the most common causes of death worldwide. Finding novel nanosized therapeutic compounds have important role to decrease the chance of death and increase the survival. Cancer cells are highly attractive to glucose [with a nanosize bimolecular structure 1nm] as an energy source more than normal cell and nanosized therapeutics due to possessing different pharmacokinetic and pharmacodynamic have advantageous over classical dosage forms in cancer therapy. The aim of the study was to synthesize Glucosamin-Porphyrin-Tamoxifen [TPG] nanosized complex as a novel selective biocompatible anti breast cancer agent. After the synthesis procedure, this complex was purified and then tested In Vitro on breast cancer cells [MCF-7] in the absence or presence of the red light and found totally successful. The results showed a good anti breast cancer activity mediated by the activation of TNF-α and necrosis/apoptosis pathways for the nanosized complex with no alteration effects on blood PT/APTT and glucose or hexokinase levels/ activity. TPG nanoconjugate seems to be very good opponents to current anti breast cancer drugs and needs to be further investigated in near future.
authors.affiliation: Department of Hepatitis and AIDS, Pasteur Institute of Iran, Tehran, Iran.
authors.forename: Massoud
authors.initials: M
authors.lastname: Amanlou
authors.forename: Zahra
authors.initials: Z
authors.lastname: Heidari
authors.forename: Seyed Davar
authors.initials: SD
authors.lastname: Siadat
authors.forename: Mohammad Reza
authors.initials: MR
authors.lastname: Aghasadeghi
authors.forename: Masoud
authors.initials: M
authors.lastname: Ghorbani
authors.forename: Seyed Esmaeil Sadat
authors.initials: SE
authors.lastname: Ebrahimi
authors.forename: Seyed Mehdi
authors.initials: SM
authors.lastname: Sadat
authors.forename: Mehdi
authors.initials: M
authors.lastname: Hajmohammadi
authors.forename: Ali Jabbari
authors.initials: AJ
authors.lastname: Arabzadeh
authors.forename: Soheila
authors.initials: S
authors.lastname: Hekmat
authors.forename: Mahmood
authors.initials: M
authors.lastname: Alaei-Beirami
authors.forename: Alireza Azizi
authors.initials: AA
authors.lastname: Saraji
authors.forename: Hadi Fathi
authors.initials: HF
authors.lastname: Moghaddam
authors.forename: Mohammad Shafiee
authors.initials: MS
authors.lastname: Alavidjeh
authors.forename: Seyed Ali
authors.initials: SA
authors.lastname: Delbaz
authors.forename: Abolfazl
authors.initials: A
authors.lastname: Dashtbani-Roozbehani
authors.forename: Mehdi Shafiee
authors.initials: MS
authors.lastname: Ardestani
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry* / Q000494:pharmacology; D017209:Apoptosis; D001943:Breast Neoplasms / Q000188:drug therapy*; D045744:Cell Line, Tumor; D005260:Female; D005944:Glucosamine / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D005947:Glucose / Q000737:chemistry*; D006801:Humans; D053758:Nanoparticles; D011166:Porphyrins / Q000138:chemical synthesis* / Q000737:chemistry* / Q000494:pharmacology; D013629:Tamoxifen / Q000031:analogs & derivatives* / Q000138:chemical synthesis* / Q000737:chemistry* / Q000494:pharmacology
chemical_list: D000970:Antineoplastic Agents; D011166:Porphyrins; D013629:Tamoxifen; D005947:Glucose; D005944:Glucosamine