title: Etanercept therapy for psoriatic arthritis in the presence of recurrent non-Hodgkin lymphoma.
abstract: Tumor necrosis factor inhibitors (TNFi) have established efficacy in psoriasis and psoriatic arthritis; however, there are concerns regarding the risk of lymphoma with their use. Although current data suggest that this risk is not increased with TNFi treatment, there are no data on the risk of recurrence of previously treated lymphoma under TNFi therapy. Herein, we describe a 46-year-old man with recurrent non-Hodgkin lymphoma whose refractory psoriatic arthritis was effectively treated for 5.5 years with the TNFi etanercept, initiated just 7 months after achieving lymphoma remission, without recurrence of non-Hodgkin lymphoma. However, he subsequently died 6.5 years later of pancreatic adenocarcinoma.
authors.affiliation: Department of Medicine, Englewood Hospital and Medical Center, Englewood, NJ, USA.
authors.forename: Sneha
authors.initials: S
authors.lastname: Pai
authors.forename: Elliot D
authors.initials: ED
authors.lastname: Rosenstein
authors.forename: Neil
authors.initials: N
authors.lastname: Kramer
mesh_terms: D015535:Arthritis, Psoriatic / Q000150:complications / Q000188:drug therapy*; D003131:Combined Modality Therapy; D000068800:Etanercept; D017809:Fatal Outcome; D006801:Humans; D007074:Immunoglobulin G / Q000627:therapeutic use*; D007166:Immunosuppressive Agents / Q000627:therapeutic use*; D008228:Lymphoma, Non-Hodgkin / Q000150:complications* / Q000473:pathology / Q000532:radiotherapy; D008297:Male; D008875:Middle Aged; D009303:Nasopharyngeal Neoplasms / Q000150:complications* / Q000473:pathology / Q000532:radiotherapy; D009364:Neoplasm Recurrence, Local; D009367:Neoplasm Staging; D018124:Receptors, Tumor Necrosis Factor / Q000627:therapeutic use*; D014409:Tumor Necrosis Factor-alpha / Q000037:antagonists & inhibitors
chemical_list: D007074:Immunoglobulin G; D007166:Immunosuppressive Agents; D018124:Receptors, Tumor Necrosis Factor; D014409:Tumor Necrosis Factor-alpha; D000068800:Etanercept