title: Utility of 18F-fluoride PET/CT and 18F-FDG PET/CT in the detection of bony metastases in heightened-risk head and neck cancer patients.
abstract: This study compared the diagnostic accuracy of (18)F-FDG PET/CT with that of (18)F-fluoride PET/CT in the detection of bony metastases in heightened-risk head and neck cancer patients.
  
  
  METHODS
  The study participants underwent (18)F-FDG PET/CT and (18)F-fluoride PET/CT within 2 wk of each another.
  
  
  RESULTS
  A total of 98 bony metastases were found in 18 of our 80 patients. (18)F-fluoride PET/CT and (18)F-FDG PET/CT showed similar lesion-based sensitivity (69.4% vs. 57.1%, P = 0.126) and areas under the curve (0.7561 vs. 0.7959, P = 0.149). Their combined interpretation demonstrated a significantly greater sensitivity and areas under the curve than that obtained with either modality alone (P < 0.001) in lesion-based analysis but not in patient-based analysis, with a treatment strategy change in 2 patients.
  
  
  CONCLUSIONS
  (18)F-fluoride PET/CT is a feasible modality for detecting bony metastases in patients with head and neck cancers, with similar sensitivity to (18)F-FDG PET/CT. Their combined use may not be justifiable.
authors.affiliation: Department of Nuclear Medicine, Chang Gung Memorial Hospital, Keelong, Taiwan.
authors.forename: Sheng-Chieh
authors.initials: SC
authors.lastname: Chan
authors.forename: Hung-Ming
authors.initials: HM
authors.lastname: Wang
authors.forename: Shu-Hang
authors.initials: SH
authors.lastname: Ng
authors.forename: Cheng-Lung
authors.initials: CL
authors.lastname: Hsu
authors.forename: Yu-Jr
authors.initials: YJ
authors.lastname: Lin
authors.forename: Chien-Yu
authors.initials: CY
authors.lastname: Lin
authors.forename: Chun-Ta
authors.initials: CT
authors.lastname: Liao
authors.forename: Tzu-Chen
authors.initials: TC
authors.lastname: Yen
mesh_terms: D001859:Bone Neoplasms / Q000000981:diagnostic imaging* / Q000556:secondary*; D005459:Fluorides; D019788:Fluorodeoxyglucose F18; D006258:Head and Neck Neoplasms / Q000473:pathology*; D006801:Humans; D007457:Iodine Radioisotopes; D008297:Male; D008875:Middle Aged; D064847:Multimodal Imaging / Q000379:methods*; D049268:Positron-Emission Tomography; D012306:Risk; D012680:Sensitivity and Specificity; D014057:Tomography, X-Ray Computed
chemical_list: D007457:Iodine Radioisotopes; D019788:Fluorodeoxyglucose F18; D005459:Fluorides