title: Development of an experimental model of cardiac failure combined with type I diabetes mellitus.
abstract: The doses and mode of streptozotocin injection for modeling heart failure combined with type 1 diabetes mellitus have been determined. Combined disease was induced in animals by injecting the selected streptozotocin dose (60 mg/kg intraperitoneally) at the stage of heart failure formation (2 weeks after coronary occlusion). This protocol of experiment led to development of hyperglycemia, body weight loss, and formation of myocardial cicatrix and hypertrophy corresponding to signs of heart failure paralleled by diabetes mellitus.
authors.affiliation: Institute of Cardiology, Tomsk Research Center, Siberian Division of the Russian Academy of Medical Sciences, Russia.
authors.forename: S A
authors.initials: SA
authors.lastname: Afanasiev
authors.forename: D S
authors.initials: DS
authors.lastname: Kondratyeva
authors.forename: S V
authors.initials: SV
authors.lastname: Popov
mesh_terms: D000818:Animals; D001786:Blood Glucose / Q000032:analysis; D054059:Coronary Occlusion; D003921:Diabetes Mellitus, Experimental / Q000150:complications / Q000473:pathology*; D004195:Disease Models, Animal; D006333:Heart Failure / Q000209:etiology / Q000473:pathology*; D008297:Male; D009203:Myocardial Infarction / Q000150:complications*; D051381:Rats; D017208:Rats, Wistar; D018709:Statistics, Nonparametric; D020257:Ventricular Remodeling / Q000502:physiology*
chemical_list: D001786:Blood Glucose