title: Pd/Cu-catalyzed C-H arylation of 1,3,4-thiadiazoles with (hetero)aryl iodides, bromides, and triflates.
abstract: The direct C-H arylation of 1,3,4-thiadiazoles with a wide range of (hetero)aryl iodides, bromides, and triflates is described using a Pd/Cu-catalyzed protocol. The methodology is compatible with substrates possessing electron-donating or electron-withdrawing substituents and also tolerates sterically hindered aryl halides. The utility of the developed protocol is demonstrated by a one-pot C-H arylation-Suzuki coupling sequence.
authors.affiliation: Laboratory for Organic & Microwave-Assisted Chemistry (LOMAC), Department of Chemistry, KU Leuven, Celestijnenlaan 200F, B-3001, Leuven, Belgium.
authors.forename: Dipak D
authors.initials: DD
authors.lastname: Vachhani
authors.forename: Abhishek
authors.initials: A
authors.lastname: Sharma
authors.forename: Erik
authors.initials: E
authors.lastname: Van der Eycken
mesh_terms: D001965:Bromides / Q000737:chemistry*; D002384:Catalysis; D003300:Copper / Q000737:chemistry*; D006846:Hydrocarbons, Halogenated / Q000737:chemistry*; D006860:Hydrogen Bonding; D007454:Iodides / Q000737:chemistry*; D015394:Molecular Structure; D010165:Palladium / Q000737:chemistry*; D013830:Thiadiazoles / Q000737:chemistry*
chemical_list: D001965:Bromides; D006846:Hydrocarbons, Halogenated; D007454:Iodides; D013830:Thiadiazoles; D010165:Palladium; D003300:Copper