title: Pharmacokinetics of liposomal gentamicin.
abstract: We present data on pharmacokinetics of free and liposomal forms of gentamicin. Comparative study of two drug forms showed that immobilization of gentamicin in liposomes significantly increased most important pharmacokinetic parameters of the antibiotic (AUC, Cmax, MRTpo, T(1/2), Kel, Vzpo) and reduced Clpo and Kel.
authors.affiliation: Volgograd Antiplague Institute, Russian Agency for Health and Consumer Rights, Russia. vari2@sprint-v.com.ru
authors.forename: K A
authors.initials: KA
authors.lastname: Rotov
authors.forename: S N
authors.initials: SN
authors.lastname: Tikhonov
authors.forename: V V
authors.initials: VV
authors.lastname: Alekseev
authors.forename: E A
authors.initials: EA
authors.lastname: Snatenkov
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000493:pharmacokinetics* / Q000494:pharmacology; D005839:Gentamicins / Q000008:administration & dosage / Q000493:pharmacokinetics* / Q000494:pharmacology; D007274:Injections, Intraperitoneal; D007457:Iodine Radioisotopes / Q000378:metabolism; D015227:Lipid Peroxidation / Q000187:drug effects; D008081:Liposomes / Q000378:metabolism* / Q000648:ultrastructure; D051379:Mice; D008854:Microscopy, Electron; D013053:Spectrophotometry; D013997:Time Factors
chemical_list: D000900:Anti-Bacterial Agents; D005839:Gentamicins; D007457:Iodine Radioisotopes; D008081:Liposomes