title: Precocious puberty in children: A review of imaging findings.
abstract: OBJECTIVE
  This review was aimed at determining the imaging findings in patients with precocious puberty.
  
  
  RESULTS
  Within a period of 8 years (from 2002 to 2010) there were 53 patients diagnosed with precocious puberty. Out of the 53 patients, 37 had undergone diagnostic imaging to detect the possible organic causes of precocious puberty. Imaging findings were positive in 31 patients and out of that, 3 patients had 2 findings each (34 abnormalities). Of the patients with positive imaging findings, central precocious puberty (gonadotrophin-dependent) was more common (81%; 25/31) and the causes included: tuber cinereum hamartoma (n = 10), glioma (n = 6), pineal gland tumour (n = 4), hydrocephalous (n = 3), arachnoid cyst (n = 2) and others (n = 3). Peripheral precocious puberty (gonadotrophin-independent) causes included: testicular adrenal rest tumour (n = 3), adrenal carcinoma (n = 1), ovarian granulosa thecal cell tumour (n = 1), and tuberous sclerosis (n = 1).
  
  
  CONCLUSIONS
  Positive imaging findings were observed in 84% (31/37) of the subjects. Hypothalamic hamartoma was the most common imaging finding in central precocious puberty while testicular adrenal rest tumour was the most common imaging finding in peripheral precocious puberty.
authors.affiliation: Department of Radiology, Universiti Kebangsaan Malaysia Medical Centre (UKMMC), Kuala Lumpur, Malaysia.
authors.forename: Mz
authors.initials: M
authors.lastname: Faizah
authors.forename: Ah
authors.initials: A
authors.lastname: Zuhanis
authors.forename: R
authors.initials: R
authors.lastname: Rahmah
authors.forename: Aa
authors.initials: A
authors.lastname: Raja
authors.forename: Ll
authors.initials: L
authors.lastname: Wu
authors.forename: Aa
authors.initials: A
authors.lastname: Dayang
authors.forename: Ma
authors.initials: M
authors.lastname: Zulfiqar