title: Predictive factors of sustained virological response for recurrent hepatitis C virus after liver transplantation: the hungarian experience.
abstract: Recurrence of hepatitis C virus (HCV) after liver transplantation (OLT) occurs consistently. Early initiation of combined antiviral treatment (AVT) has become a standard treatment seeking to achieve sustained virological response (SVR). We evaluated the files of 108 HCV-positive patients between 2003 and 2010. Seventy-two (72) experienced recurrent HCV within 12 months, 31 of whom completed the AVT (43%) but 9 (29%) exhibited SVR. Factors with impacting SVR were male recipient, no fatty changes in the donor liver, short warm ischemia time, cyclosporine-based immunosuppression, neither infective, septic or bleeding complication nor acute rejection episode and a rapid viral response to AVT. De novo diabetes, and unsuccessful AVT prior to OLT were strongly associated with a a failed SVR. The 1- and 3-year cumulative patient survival rates trended to be better in cases of SVR compared with nonresponders (100% and 100% versus 94% and 89%; P = .07).
authors.affiliation: Clinic of Transplantation and Surgery, Semmelweis University Budapest, Budapest, Hungary. abnemes@hotmail.com
authors.forename: B
authors.initials: B
authors.lastname: Nemes
authors.forename: F
authors.initials: F
authors.lastname: Gelley
authors.forename: G
authors.initials: G
authors.lastname: Zádori
authors.forename: A
authors.initials: A
authors.lastname: Kiss
authors.forename: P
authors.initials: P
authors.lastname: Nagy
authors.forename: Z
authors.initials: Z
authors.lastname: Gerlei
authors.forename: G
authors.initials: G
authors.lastname: Lengyel
authors.forename: E
authors.initials: E
authors.lastname: Sárváry
mesh_terms: D000328:Adult; D005260:Female; D016174:Hepacivirus / Q000302:isolation & purification*; D049670:History, 17th Century; D006801:Humans; D007166:Immunosuppressive Agents / Q000008:administration & dosage; D016031:Liver Transplantation; D008297:Male; D012008:Recurrence
chemical_list: D007166:Immunosuppressive Agents