title: Al3+ ion cross-linked interpenetrating polymeric network microbeads from tailored natural polysaccharides.
abstract: Interpenetrating network (IPN) microbeads of sodium carboxymethyl locust bean gum (SCMLBG) and sodium carboxymethyl cellulose (SCMC) containing diclofenac sodium (DS), a non steroidal anti-inflammatory drug were prepared by single water-in-water (w/w) emulsion gelation process using AlCl(3) as cross-linking agent in a complete aqueous environment. The influence of different variables like total polymer concentration, gelation time and crosslinker content on in vitro physico-chemical characteristics and drug release rate in different media was investigated. Drug loaded microbeads were evaluated through Fourier transform infra-red (FTIR), X-ray diffraction (XRD) and differential scanning calorimetry (DSC) analyses. Scanning electron microscopy (SEM) micrograph of the beads suggested the formation of spherical particles. FTIR analysis indicated the stable nature of the drug in the blend microbeads. DSC and XRD analysis revealed amorphous state of drug after encapsulation. The drug release profile in acidic medium was considerably less in comparison to alkaline media. Formulations showed non-Fickian type transport mechanism. These tri-valent ion crosslinked beads not only improve drug encapsulation efficiency but also enhance drug release in phosphate buffer.
authors.affiliation: School of Pharmaceutical Sciences, IFTM University, Moradabad 244001, Uttar Pradesh, India. shivsankar.bhattacharya@gmail.co.in
authors.forename: Shiv Sankar
authors.initials: SS
authors.lastname: Bhattacharya
authors.forename: Ashoke Kumar
authors.initials: AK
authors.lastname: Ghosh
authors.forename: Subham
authors.initials: S
authors.lastname: Banerjee
authors.forename: Pronobesh
authors.initials: P
authors.lastname: Chattopadhyay
authors.forename: Amitava
authors.initials: A
authors.lastname: Ghosh
mesh_terms: D000077410:Aluminum Chloride; D017607:Aluminum Compounds / Q000737:chemistry*; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000737:chemistry; D001688:Biological Products / Q000737:chemistry*; D002266:Carboxymethylcellulose Sodium / Q000737:chemistry*; D002712:Chlorides / Q000737:chemistry*; D004008:Diclofenac / Q000737:chemistry; D004337:Drug Carriers / Q000737:chemistry*; D005685:Galactans / Q000737:chemistry*; D020100:Hydrogels / Q000737:chemistry; D008351:Mannans / Q000737:chemistry*; D008863:Microspheres; D053149:Plant Gums / Q000737:chemistry*; D013499:Surface Properties; D013997:Time Factors; D014867:Water / Q000737:chemistry
chemical_list: D017607:Aluminum Compounds; D000894:Anti-Inflammatory Agents, Non-Steroidal; D001688:Biological Products; D002712:Chlorides; D004337:Drug Carriers; D005685:Galactans; D020100:Hydrogels; D008351:Mannans; D053149:Plant Gums; D014867:Water; D004008:Diclofenac; D000077410:Aluminum Chloride; D002266:Carboxymethylcellulose Sodium; C017471:locust bean gum