title: The first identification of rare human group A rotavirus strain G3P[10] with severe infantile diarrhea in eastern India.
abstract: During an ongoing surveillance for diarrheal pathogens, an unusual human group A rotavirus strain G3P[10] (RVA/Human-wt/IND/mcs60/2011/G3P[10]) was detected in a stool sample of a 14 months old girl child with acute diarrhea in Kolkata, eastern India. The VP7 nucleotide sequence of this strain revealed a close phylogenetic relationship to the prototype G3 strain AU-1 and Australian feline strain Cat2, whereas, the VP4 gene segment was closely related to the G8P[10] rotavirus 69M from Indonesia. Analysis of 11 gene segments of this unusual G3P[10] strain demonstrates a complex evolutionary pattern, with genes possibly derived from the group A rotaviruses of human DS-1-like and AU-1-like strains of simian and caprine host species. To our knowledge, this is the first complete genotyping report of any G3P[10] rotavirus, worldwide.
authors.affiliation: Division of Virology, National Institute of Cholera and Enteric Diseases, P-33 CIT Road Scheme XM, Beliaghata, Kolkata 700 010, West Bengal, India.
authors.forename: Anupam
authors.initials: A
authors.lastname: Mukherjee
authors.forename: Satarupa
authors.initials: S
authors.lastname: Mullick
authors.forename: Nobumichi
authors.initials: N
authors.lastname: Kobayashi
authors.forename: Mamta
authors.initials: M
authors.lastname: Chawla-Sarkar
mesh_terms: D000208:Acute Disease; D000818:Animals; D000956:Antigens, Viral / Q000235:genetics; D036022:Capsid Proteins / Q000235:genetics; D016000:Cluster Analysis; D003967:Diarrhea / Q000821:virology*; D005243:Feces / Q000821:virology; D005260:Female; D005838:Genotype; D006801:Humans; D007194:India; D007223:Infant; D010802:Phylogeny; D016865:Reassortant Viruses / Q000235:genetics; D012401:Rotavirus / Q000145:classification / Q000235:genetics* / Q000302:isolation & purification; D012400:Rotavirus Infections / Q000821:virology*
chemical_list: D000956:Antigens, Viral; D036022:Capsid Proteins; C050779:VP7 protein, Rotavirus