title: Does prenatal methamphetamine exposure induce cross-sensitization to cocaine and morphine in adult male rats?
abstract: The aim of the present study was to examine the cross-sensitization           induced by prenatal methamphetamine (MA) exposure to challenge dose of           cocaine or morphine. Rat mothers received a daily injection of MA (5 mg/kg) or           saline throughout the gestation period. Adult male offspring (prenatally MA- or           saline-exposed) were divided to groups with challenge doses of saline (1 ml/kg),           cocaine (5 mg/kg) or morphine (5 mg/kg). Behavior in unknown environment was           examined in Laboras, nociception in Plantar test, and active drug-seeking behavior           in conditioned place preference (CPP). Our data demonstrate that cocaine           increased the exploratory activity in Laboras test in prenatally saline-exposed,           but decreased it in prenatally MA-exposed rats. An analgesic effect of cocaine was           demonstrated only by the tail withdrawal and it was independent of the prenatal           drug exposure. CPP test showed that prenatal MA exposure induced rather           tolerance than sensitization to cocaine. In contrast to cocaine effects, morphine           decreased rearing activity in both, prenatally MA-exposed and saline-exposed rats,           and locomotion only in prenatally MA-exposed rats in the Laboras. In the Plantar           test, the results demonstrated that morphine had an analgesic effect in prenatally           saline-exposed rats but this effect was suppressed in prenatally MA-exposed rats.           In the CPP test morphine induced drug-seeking behavior, which however was not           affected by prenatal drug exposure. Thus, our data demonstrate that there is a           cross-effect between prenatal MA exposure and the challenge dose of other drug           in adulthood, however drug-seeking behavior is not increased by prenatal MA           exposure as we expected.
authors.affiliation: Department of Normal, Pathological and Clinical Physiology, Charles University, Prague, Czech Republic. rslamber@lf3.cuni.cz
authors.forename: R
authors.initials: R
authors.lastname: Slamberová
authors.forename: A
authors.initials: A
authors.lastname: Yamamotová
authors.forename: M
authors.initials: M
authors.lastname: Pometlová
authors.forename: B
authors.initials: B
authors.lastname: Schutová
authors.forename: L
authors.initials: L
authors.lastname: Hrubá
authors.forename: K
authors.initials: K
authors.lastname: Nohejlová-Deykun
authors.forename: E
authors.initials: E
authors.lastname: Nová
authors.forename: E
authors.initials: E
authors.lastname: Macúchová
mesh_terms: D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects*; D003042:Cocaine / Q000494:pharmacology*; D058999:Drug-Seeking Behavior / Q000187:drug effects*; D005260:Female; D008297:Male; D008694:Methamphetamine / Q000494:pharmacology*; D009020:Morphine / Q000494:pharmacology*; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D051381:Rats
chemical_list: D008694:Methamphetamine; D009020:Morphine; D003042:Cocaine