title: A chemically programmed antibody is a long-lasting and potent inhibitor of influenza neuraminidase.
abstract: Programming an anti-flu strategy: A new and potent neuraminidase inhibitor that maintains long-term systemic exposure of an antibody and the therapeutic activity of the neuraminadase inhibitor zanamivir has been created. This strategy could provide a promising new class of influenza A drugs for therapy and prophylaxis, and validates enzyme inhibitors as programming agents in synthetic immunology.
authors.affiliation: Department of Chemistry, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA.
authors.forename: Masahiko
authors.initials: M
authors.lastname: Hayakawa
authors.forename: Narihiro
authors.initials: N
authors.lastname: Toda
authors.forename: Nancy
authors.initials: N
authors.lastname: Carrillo
authors.forename: Natalie J
authors.initials: NJ
authors.lastname: Thornburg
authors.forename: James E
authors.initials: JE
authors.lastname: Crowe
authors.forename: Carlos F
authors.initials: CF
authors.lastname: Barbas
mesh_terms: D000818:Animals; D000911:Antibodies, Monoclonal / Q000737:chemistry* / Q000493:pharmacokinetics / Q000494:pharmacology; D000998:Antiviral Agents / Q000737:chemistry* / Q000493:pharmacokinetics / Q000494:pharmacology; D057930:Click Chemistry; D005634:Fructose-Bisphosphate Aldolase / Q000276:immunology; D006801:Humans; D018796:Immunoconjugates / Q000737:chemistry* / Q000493:pharmacokinetics / Q000494:pharmacology; D009980:Influenza A virus / Q000187:drug effects / Q000201:enzymology*; D007251:Influenza, Human / Q000188:drug therapy / Q000821:virology; D051379:Mice; D008958:Models, Molecular; D009439:Neuraminidase / Q000037:antagonists & inhibitors* / Q000378:metabolism; D009976:Orthomyxoviridae Infections / Q000188:drug therapy / Q000821:virology; D053243:Zanamivir / Q000737:chemistry* / Q000493:pharmacokinetics / Q000494:pharmacology
chemical_list: D000911:Antibodies, Monoclonal; D000998:Antiviral Agents; D018796:Immunoconjugates; D009439:Neuraminidase; D005634:Fructose-Bisphosphate Aldolase; D053243:Zanamivir