title: The role of long non-coding RNA in transcriptional gene silencing.
abstract: Transcriptional gene silencing controls the activity of transposable elements and expression of protein-coding genes. It requires non-coding transcription, which in plants is performed by RNA Polymerases IV and V (Pol IV and Pol V). Pol IV produces precursors for siRNA biogenesis while Pol V produces scaffold transcripts required for siRNAs and associated proteins to recognize their target loci. In this review I discuss the mechanisms used by Pol IV and Pol V to mediate repressive chromatin modifications. I further discuss the mechanisms controlling non-coding transcription and their role in regulation of genome activity.
authors.affiliation: University of Michigan, Department of Molecular, Cellular and Developmental Biology, Ann Arbor, MI 48109, USA. wierzbic@umich.edu
authors.forename: Andrzej T
authors.initials: AT
authors.lastname: Wierzbicki
mesh_terms: D017360:Arabidopsis / Q000235:genetics / Q000378:metabolism; D029681:Arabidopsis Proteins / Q000235:genetics; D019175:DNA Methylation; D012321:DNA-Directed RNA Polymerases / Q000235:genetics; D018506:Gene Expression Regulation, Plant / Q000235:genetics*; D020868:Gene Silencing; D008958:Models, Molecular; D010940:Plant Proteins / Q000235:genetics*; D010944:Plants / Q000235:genetics* / Q000378:metabolism; D062085:RNA, Long Noncoding / Q000235:genetics / Q000378:metabolism*; D034741:RNA, Small Interfering / Q000235:genetics; D014158:Transcription, Genetic
chemical_list: D029681:Arabidopsis Proteins; D010940:Plant Proteins; D062085:RNA, Long Noncoding; D034741:RNA, Small Interfering; C499181:RNA polymerase IV, Arabidopsis; C538841:RNA polymerase V, Arabidopsis; D012321:DNA-Directed RNA Polymerases