title: Use of antimetabolites in the reconstruction of severe anophthalmic socket contraction.
abstract: OBJECTIVE
  The use of antimetabolites is well established in ophthalmology with expanded uses still being defined. We describe our experience of antimetabolite use in the reconstruction of severe anophthalmic socket contraction.
  
  
  METHODS
  Nonrandomized, retrospective case series. The medical records and clinical photographs of 5 patients with severe socket contraction were reviewed. Either 5-Fluorouracil (5-FU) (50 mg/ml) or Mitomycin C (MMC) (0.4 mg/ml) was used during the course of the surgery via direct injection into the operative bed in the area of scarring. In addition, in 3 cases, 5-FU was also applied after surgery, in the clinic setting. Variables examined included: number of previous socket operations; preoperative ability to retain a prosthesis; type of socket reconstruction; type, amount, and location of antimetabolite injected; number of postoperative injections; average follow-up; and the postoperative ability to retain a prosthesis.
  
  
  RESULTS
  All 5 patients had multiple operations previously. After surgery, all 5 were able to retain an ocular prosthesis. We did not observe any delay in wound healing, implant exposure, or extrusion, and no significant side effects were noted.
  
  
  CONCLUSIONS
  The use of adjunct antimetabolite in severe anophthalmic socket reconstruction is an effective option that is well tolerated with minimal side effects.
authors.affiliation: UCSD Department of Ophthalmology, Division of Oculofacial Plastic and Reconstructive Surgery, Shiley Eye Center, La Jolla, California 92093-0946, USA.
authors.forename: Ayelet
authors.initials: A
authors.lastname: Priel
authors.forename: Sang-Rog
authors.initials: SR
authors.lastname: Oh
authors.forename: Katherine M
authors.initials: KM
authors.lastname: Whipple
authors.forename: Bobby S
authors.initials: BS
authors.lastname: Korn
authors.forename: Don O
authors.initials: DO
authors.lastname: Kikkawa
mesh_terms: D000328:Adult; D000963:Antimetabolites / Q000627:therapeutic use*; D015353:Eye Enucleation; D005137:Eye, Artificial; D005260:Female; D005472:Fluorouracil / Q000627:therapeutic use; D006801:Humans; D008297:Male; D008875:Middle Aged; D016685:Mitomycin / Q000627:therapeutic use; D009916:Orbital Diseases / Q000188:drug therapy / Q000601:surgery*; D020273:Orbital Implants; D019651:Plastic Surgery Procedures; D012189:Retrospective Studies
chemical_list: D000963:Antimetabolites; D016685:Mitomycin; D005472:Fluorouracil