title: Continuous renal replacement therapy in neonates weighing less than 3 kg.
abstract: OBJECTIVE
  Continuous renal replacement therapy (CRRT) is becoming the treatment of choice for supporting critically ill pediatric patients. However, a few studies present have reported CRRT use and outcome in neonates weighing less than 3 kg. The aim of this study is to describe the clinical application, outcome, and complications of CRRT in small neonates.
  
  
  METHODS
  A retrospective review was performed in 8 neonatal patients who underwent at least 24 hours of pumped venovenous CRRT at the Samsung Medical Center in Seoul, Korea, between March 2007 and July 2010. Data, including demographic characteristics, diagnosis, vital signs, medications, laboratory, and CRRT parameters were recorded.
  
  
  RESULTS
  The data of 8 patients were analyzed. At the initiation of CRRT, the median age was 5 days (corrected age, 38(+2) weeks to 23 days), and the median body weight was 2.73 kg (range, 2.60 to 2.98 kg). Sixty-two patient-days of therapy were reviewed; the median time for CRRT in each patient was 7.8 days (range, 1 to 37 days). Adverse events included electrolyte disturbances, catheter-related complications, and CRRT-related hypotension. The mean circuit functional survival was 13.9±8.6 hours. Overall, 4 patients (50%) survived; the other 4 patients, who developed multiorgan dysfunction syndrome, died.
  
  
  CONCLUSIONS
  The complications of CRRT in newborns are relatively high. However, the results of this study suggest that venovenous CRRT is feasible and effective in neonates weighing less than 3 kg under elaborate supportive care. Furthermore, for using potential benefit of CRRT in neonates, efforts are required for prolonging filter survival.
authors.affiliation: Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
authors.forename: Young Bae
authors.initials: YB
authors.lastname: Sohn
authors.forename: Kyung Hoon
authors.initials: KH
authors.lastname: Paik
authors.forename: Hee Yeon
authors.initials: HY
authors.lastname: Cho
authors.forename: Su Jin
authors.initials: SJ
authors.lastname: Kim
authors.forename: Sung Won
authors.initials: SW
authors.lastname: Park
authors.forename: Eun Sun
authors.initials: ES
authors.lastname: Kim
authors.forename: Yun Sil
authors.initials: YS
authors.lastname: Chang
authors.forename: Won-Soon
authors.initials: WS
authors.lastname: Park
authors.forename: Yoon-Ho
authors.initials: YH
authors.lastname: Choi
authors.forename: Dong-Kyu
authors.initials: DK
authors.lastname: Jin