title: Postoperative infections are associated with adverse outcome after resection with curative intent for colorectal cancer.
abstract: This study focused on the impact of post-operative infection on patient outcome after resection with curative intent for colorectal cancer. Postoperative surgical and medical complications have been implicated as a negative predictor of long-term outcome in various malignancies. We studied a population of 1083 patients who underwent resection with curative intent for colorectal cancer. These patients were divided into 2 groups based on the occurrence (65 patients, 6%) or absence (1018 patients, 94%) of postoperative complications due to infection. We investigated the demographic and clinicopathological features of each patient with and without postoperative infectious complications, as well as the impact of postoperative infection on long-term survival. Results showed that patients with postoperative infectious complications had diabetes mellitus more frequently and also had urgent surgery compared to those without infectious complications. In addition, patients with postoperative infectious complications had a significantly more unfavorable outcome compared with those without postoperative infection in cancer-specific, but not overall survival. Multivariate analysis demonstrated that age, rectal cancer and tumor stage correlated with overall survival, but not postoperative infectious complications. However, postoperative infections, as well as gender, were associated with the length of time until the patient succumbed from the recurrence of colorectal cancer after resection for curative intent. Thus, postoperative infectious complications are predictors of adverse clinical outcome in patients with colorectal cancer. However, further immunological study is necessary to confirm the biological significance of these findings.
authors.affiliation: Department of Surgery, National Defense Medical College, Tokorozawa 359-8513, Japan.
authors.forename: Hironori
authors.initials: H
authors.lastname: Tsujimoto
authors.forename: Hideki
authors.initials: H
authors.lastname: Ueno
authors.forename: Yojiro
authors.initials: Y
authors.lastname: Hashiguchi
authors.forename: Satoshi
authors.initials: S
authors.lastname: Ono
authors.forename: Takashi
authors.initials: T
authors.lastname: Ichikura
authors.forename: Kazuo
authors.initials: K
authors.lastname: Hase