title: CYP1A1 Ile462Val polymorphism contributes to lung cancer susceptibility among lung squamous carcinoma and smokers: a meta-analysis.
abstract: Many studies have examined the association between the CYP1A1 Ile462Val gene polymorphisms and lung cancer risk in various populations, but their results have been inconsistent. To assess this relationship more precisely, a meta-analysis was performed. Ultimately, 43 case-control studies, comprising 19,228 subjects were included. A significantly elevated lung cancer risk was associated with 2 Ile462Val genotype variants (for Val/Val vs Ile/Ile: OR = 1.22, 95% CI = 1.08-1.40; for (Ile/Val +Val/Val) vs Ile/Ile: OR = 1.15, 95% CI = 1.07-1.23) in overall population. In the stratified analysis, a significant association was found in Asians, Caucasians and lung SCC, not lung AC and lung SCLC. Additionally, a significant association was found in smoker population and not found in non-smoker populations. This meta-analysis suggests that the Ile462Val polymorphisms of CYP1A1 correlate with increased lung cancer susceptibility in Asian and Caucasian populations and there is an interaction with smoking status, but these associations vary in different histological types of lung caner.
authors.affiliation: Jiangsu Province Hospital of Traditional Chinese Medicine, Nanjing, China. jiyanan1128@163.com
authors.forename: Ya-Nan
authors.initials: YN
authors.lastname: Ji
authors.forename: Qin
authors.initials: Q
authors.lastname: Wang
authors.forename: Li-Jun
authors.initials: LJ
authors.lastname: Suo
mesh_terms: D002294:Carcinoma, Squamous Cell / Q000235:genetics*; D016022:Case-Control Studies; D019363:Cytochrome P-450 CYP1A1 / Q000235:genetics*; D005091:Exons; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D007532:Isoleucine / Q000737:chemistry*; D008175:Lung Neoplasms / Q000235:genetics*; D008957:Models, Genetic; D016017:Odds Ratio; D011110:Polymorphism, Genetic; D012907:Smoking; D014633:Valine / Q000737:chemistry*
chemical_list: D007532:Isoleucine; D019363:Cytochrome P-450 CYP1A1; D014633:Valine