title: Genomics-driven discovery of taiwachelin, a lipopeptide siderophore from Cupriavidus taiwanensis.
abstract: A genome mining study led to the identification of a previously unrecognised siderophore biosynthesis gene cluster in the nitrogen-fixing bacterium Cupriavidus taiwanensis LMG19424. Based upon predicted structural residues, a convenient strategy for an NMR-assisted isolation of the associated metabolite was designed. The structure of the purified siderophore, taiwachelin, was fully characterized by spectroscopic methods and chemical derivatisation.
authors.affiliation: Leibniz Institute for Natural Product Research and Infection Biology, HKI, Beutenbergstr. 11a, D-07745, Jena, Germany.
authors.forename: Martin F
authors.initials: MF
authors.lastname: Kreutzer
authors.forename: Markus
authors.initials: M
authors.lastname: Nett
mesh_terms: D019295:Computational Biology; D049921:Cupriavidus / Q000737:chemistry* / Q000235:genetics*; D023281:Genomics; D055666:Lipopeptides / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D017262:Siderophores / Q000737:chemistry*; D017550:Spectroscopy, Fourier Transform Infrared
chemical_list: D055666:Lipopeptides; D017262:Siderophores; C580725:taiwachelin