title: Evolution of blood pressure from adolescents to youth in salt sensitivies: a 18-year follow-up study in Hanzhong children cohort.
abstract: BACKGROUND
  Essential hypertension mostly originates from children. Salt Sensitivity (SS) is regarded as the intermediate phenotype of essential hypertension. The present study investigated the effects of salt-sensitivity on evolution of blood pressure (BP) and development to hypertension from adolescents to youth.
  
  
  METHODS
  A baseline survey was carried out in 4,623 adolescents aged 6-15 years old in Hanzhong rural areas in 1987, 310 of whom (mean 9.2 years) were randomly recruited for determination of salt sensitivity using the tests of oral saline load and furosemide sodium-volume depletion. SS was diagnosed in 101 subjects while 209 were determined as non-salt-sensitive (NSS). We made a 18-year followed-up of the cohort in 2005.
  
  
  RESULTS
  The response rate for surviving baseline adolescents was 71.9%. At follow up, BP in youth with baseline SS was higher than that in NSS (SBP:122.9 ± 13.1 VS 117.3 ± 12.4, P < 0.01; DBP: 78.2 ± 10.4 VS 74.7 ± 10.8, P < 0.05). Longitudinal analysis of 18-year BP evolution, subjects in SS had greater Systolic BP change than subjects in NSS(19.6 ± 12.714.7 ± 12.2, P < 0.01). The incidence of hypertension in salt sensitive group was higher than that in NSS group (15.5% VS 6.3%, RR = 2.34, P < 0.05).
  
  
  CONCLUSIONS
  Our findings indicate that adolescents with higher BP salt-sensitivity have a higher rate of incident hypertension in youth. Salt sensitivity could be at high risk predisposing to development of hypertension from adolescents to youth.
authors.affiliation: Department of Cardiology, First Affiliated Hospital of Medical College, Xian Jiaotong University, Xian Shaanxi, 710061, PR China. mujjun@163.com
authors.forename: Jianjun
authors.initials: J
authors.lastname: Mu
authors.forename: Shuhui
authors.initials: S
authors.lastname: Zheng
authors.forename: Qiufang
authors.initials: Q
authors.lastname: Lian
authors.forename: Fuqiang
authors.initials: F
authors.lastname: Liu
authors.forename: Zhiquan
authors.initials: Z
authors.lastname: Liu
mesh_terms: D000293:Adolescent; D041923:Adolescent Development; D002648:Child; D002657:Child Development; D002681:China / Q000453:epidemiology; D015331:Cohort Studies; D018450:Disease Progression; D000075222:Essential Hypertension; D005260:Female; D005500:Follow-Up Studies; D006306:Health Surveys; D006801:Humans; D006973:Hypertension / Q000453:epidemiology* / Q000208:ethnology / Q000209:etiology; D015994:Incidence; D008137:Longitudinal Studies; D008297:Male; D058246:Prehypertension / Q000453:epidemiology* / Q000208:ethnology / Q000503:physiopathology; D011446:Prospective Studies; D012307:Risk Factors; D012423:Rural Health / Q000208:ethnology; D017673:Sodium Chloride, Dietary / Q000009:adverse effects*
chemical_list: D017673:Sodium Chloride, Dietary