title: Priming the engine of DNA synthesis.
abstract: In this issue of Structure, Rymer and colleagues present the first crystal structures of a bacterial DnaG primase with bound substrate NTPs and alarmone inhibitors. A thoughtful comparative structural analysis provides important insights into the chemical mechanism of primase.
authors.affiliation: School of Chemistry, University of Wollongong, New South Wales 2522, Australia.
authors.forename: Robyn E
authors.initials: RE
authors.lastname: Mansfield
authors.forename: Nicholas E
authors.initials: NE
authors.lastname: Dixon
mesh_terms: D001426:Bacterial Proteins / Q000737:chemistry*; D019915:DNA Primase / Q000737:chemistry*; D003854:Deoxyribonucleotides / Q000737:chemistry*; D006158:Guanosine Pentaphosphate / Q000737:chemistry*; D006159:Guanosine Tetraphosphate / Q000737:chemistry*; D013211:Staphylococcus aureus / Q000201:enzymology*
chemical_list: D001426:Bacterial Proteins; D003854:Deoxyribonucleotides; D006159:Guanosine Tetraphosphate; D006158:Guanosine Pentaphosphate; D019915:DNA Primase