title: Prophylactic antibiotic administration for prevention of surgical site infection in  urological laparoscopic surgeries.
abstract: BACKGROUND
  The purpose of this study is to investigate the occurrence of surgical site infection (SSI) in our cases after laparoscopic surgery with prophylactic antibiotics administration (PAA) of 1-2 days or 3 days duration.
  
  
  METHODS
  Two hundred and nine patients were enrolled in this study. SSIs were categorized as urinary tract and/or wound infection. Laboratory data relating to infection such as serum white blood cell (WBC) and C-reactive protein (CRP) were investigated after surgeries and compared to the data before surgeries. Data were collected and analyzed retrospectively.
  
  
  RESULTS
  There were 4 SSI patients in total. SSI was 4/125 (3.2 %) cases of PAA of 1-2 days (shorter) duration patients and there was 0/84 (0 %) of PAA of 3 days (longer) duration. Longer group showed the tendency of lower SSI ratio even though the difference did not reach statistically significant (p=0.0978) because of small number of SSI cases and ratios. Change of serum WBC at 4th day from pre-surgery was significantly suppressed in longer group than shorter group.
  
  
  CONCLUSIONS
  Our data showed 3-days of PAA might be better to be selected according to the cases especially such as, for instance, immune-compromised hosts. Future prospective study with more number of patients may be necessary for further evaluation.
authors.affiliation: Division of Urology, Department of Organs Therapeutics, Faculty of Medicine,  Kobe University Graduate School of Medicine, Kobe 650-0017, Japan.
authors.forename: Minori
authors.initials: M
authors.lastname: Matsumoto
authors.forename: Katsumi
authors.initials: K
authors.lastname: Shigemura
authors.forename: Fukashi
authors.initials: F
authors.lastname: Yamamichi
authors.forename: Yuzo
authors.initials: Y
authors.lastname: Nakano
authors.forename: Kazushi
authors.initials: K
authors.lastname: Tanaka
authors.forename: Soichi
authors.initials: S
authors.lastname: Arakawa
authors.forename: Masato
authors.initials: M
authors.lastname: Fujisawa
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D019072:Antibiotic Prophylaxis / Q000706:statistics & numerical data*; D005260:Female; D006801:Humans; D010535:Laparoscopy; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D013530:Surgical Wound Infection / Q000517:prevention & control*; D013520:Urologic Surgical Procedures; D055815:Young Adult