title: A new gorgostane derivative from the Egyptian Red Sea soft coral Heteroxenia ghardaqensis.
abstract: Chemical investigation of the chloroform extract of the Egyptian Red Sea soft coral, Heteroxenia ghardaqensis (Family Xeniidae), led to the isolation of three gorgostane derivatives, namely gorgosten-5(E)-3β-ol (1), gorgostan-3β,5α,6β, 11α-tetraol (sarcoaldosterol A) (2) and gorgostan-3β,5α,6β-triol-11α-acetate (3). To our knowledge, sterol 3 is reported in this article for the first time. The structure elucidation of these compounds was deduced by 1-D and 2-D NMR as well as ESIMS. Sterol 1 showed moderate activity as growth inhibitor of human colon tumour cell lines.
authors.affiliation: Department of Chemistry of Natural Compounds, National Research Center, Dokki 12622, Cairo, Egypt.
authors.forename: Abdelsamed I
authors.initials: AI
authors.lastname: Elshamy
authors.forename: Ayman F
authors.initials: AF
authors.lastname: Abdel-Razik
authors.forename: Mahmoud I
authors.initials: MI
authors.lastname: Nassar
authors.forename: Tahia K
authors.initials: TK
authors.lastname: Mohamed
authors.forename: Mohamed A
authors.initials: MA
authors.lastname: Ibrahim
authors.forename: Salah M
authors.initials: SM
authors.lastname: El-Kousy
mesh_terms: D000818:Animals; D037421:Anthozoa / Q000737:chemistry*; D018938:Caco-2 Cells; D002470:Cell Survival / Q000187:drug effects; D002725:Chloroform; D045424:Complex Mixtures / Q000737:chemistry*; D004305:Dose-Response Relationship, Drug; D004534:Egypt; D006801:Humans; D019156:Indian Ocean; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D013261:Sterols / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*
chemical_list: D045424:Complex Mixtures; D013261:Sterols; D002725:Chloroform