title: Ginsenosides extracted from nanoscale Chinese white ginseng enhances anticancer effect.
abstract: Ginsenosides, the major chemical composition of Chinese white ginseng (Panax ginseng C. A. Meyer), can inhibit tumor, enhance body immune function, prevent neurodegeneration. In this paper, for the first time we reported that the amount of ginsenosides in the equivalent extraction of the nanoscale Chinese white ginseng particles (NWGP) was 2.5 times more than that of microscale Chinese white ginseng particles (WGP). And the extractions from NWGP (1000 microg/ml) reached a high tumor inhibition of 64% exposed to human lung carcinoma cells (A549) and 74% exposed to human cervical cancer cells (Hela) after 72 h. Our work shows that the nanoscale Chinese WGP greatly improves the bioavailability of ginsenosides.
authors.affiliation: School of Chinese Medicinal Material, Jilin Agricultural University, Changchun 130118, P. R. China.
authors.forename: Yanxia
authors.initials: Y
authors.lastname: Ji
authors.forename: Ziyu
authors.initials: Z
authors.lastname: Rao
authors.forename: Jinlei
authors.initials: J
authors.lastname: Cui
authors.forename: Haiying
authors.initials: H
authors.lastname: Bao
authors.forename: Chunying
authors.initials: C
authors.lastname: Chen
authors.forename: Chunying
authors.initials: C
authors.lastname: Shu
authors.forename: Jian Ru
authors.initials: JR
authors.lastname: Gong
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000494:pharmacology*; D045744:Cell Line, Tumor; D002851:Chromatography, High Pressure Liquid; D036145:Ginsenosides / Q000302:isolation & purification*; D049672:History, 19th Century; D006801:Humans; D008855:Microscopy, Electron, Scanning; D036103:Nanotechnology; D005894:Panax / Q000737:chemistry*; D010936:Plant Extracts / Q000494:pharmacology*
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D036145:Ginsenosides; D010936:Plant Extracts