title: [Survey on examinations for diagnosis of bone marrow failure in Japan: a report from the Japanese National Research Group on Idiopathic Bone Marrow Failure Syndromes].
abstract: Using a registration sheet of a prospective registration system for aplastic anemia (AA)/myelodysplastic syndromes (MDS), by the National Research Group on Idiopathic Bone Marrow Failure Syndromes, Japan, we carried out a survey on examinations for diagnosis of bone marrow failure. Bone marrow trephine biopsy was performed in 66 of 105 cases (63%) [Original diagnosis: AA 51 cases (80%), MDS 12 (32%), undiagnosable 3 (75%)]. Bone marrow aspiration was performed in all cases, and aspiration was performed at least twice in 36 cases (34%). The first-line anatomic site for bone marrow aspiration was the posterior iliac crest (62%). Cytogenetic examination was performed in 93%. The concordance rate between the original and the central review diagnosis was 93% among the studied cases: AA, Idiopathic cytopenia of undetermined significance (ICUS) and MDS in total. Flow cytometry analysis to detect paroxysmal nocturnal hemoglobinuria (PNH)-type blood cells was performed in 32%.
authors.affiliation: Division of Hematology, Department of Internal Medicine, Faculty of Medicine, Saitama Medical University.
authors.forename: Kayano
authors.initials: K
authors.lastname: Araseki
authors.forename: Akira
authors.initials: A
authors.lastname: Matsuda
authors.forename: Kaoru
authors.initials: K
authors.lastname: Tohyama
authors.forename: Takayuki
authors.initials: T
authors.lastname: Ishikawa
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Kawabata
authors.forename: Yasushi
authors.initials: Y
authors.lastname: Miyazaki
authors.forename: Shinji
authors.initials: S
authors.lastname: Nakao
authors.forename: Masao
authors.initials: M
authors.lastname: Tomonaga
authors.forename: Akifumi
authors.initials: A
authors.lastname: Takaori-Kondo
authors.forename: Mineo
authors.initials: M
authors.lastname: Kurokawa
authors.forename: Mitsuhiro
authors.initials: M
authors.lastname: Omine
authors.forename: Keiya
authors.initials: K
authors.lastname: Ozawa
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000741:Anemia, Aplastic / Q000175:diagnosis* / Q000473:pathology; D001707:Biopsy, Needle; D001853:Bone Marrow / Q000473:pathology*; D020732:Cytogenetic Analysis; D005260:Female; D005434:Flow Cytometry; D006457:Hemoglobinuria, Paroxysmal / Q000175:diagnosis; D006801:Humans; D007085:Ilium / Q000473:pathology; D007564:Japan; D008297:Male; D008875:Middle Aged; D009190:Myelodysplastic Syndromes / Q000175:diagnosis* / Q000473:pathology; D055815:Young Adult