title: Application of a stochastic model to response assessments in a study of squamous cell carcinoma of the head and neck.
abstract: This paper discusses the application of a stochastic model in the analysis of response assessments made at various time points in a clinical trial of patients with squamous cell carcinoma of the head and neck. The transition rates and probabilities during treatment administration are derived using maximum likelihood methods. The results are then compared with the standard analyses used in solid tumour studies. Stochastic modelling is considered to complement the standard analyses, provide a holistic approach and better explain the underlying disease process.
authors.affiliation: GlaxoSmithKline, Oncology Biometrics and Epidemiology, Uxbridge, Middlesex, UK. habib.h.hassani@gsk.com
authors.forename: Habib
authors.initials: H
authors.lastname: Hassani
mesh_terms: D000970:Antineoplastic Agents / Q000627:therapeutic use; D002294:Carcinoma, Squamous Cell / Q000473:pathology / Q000628:therapy*; D003131:Combined Modality Therapy; D004311:Double-Blind Method; D006258:Head and Neck Neoplasms / Q000473:pathology / Q000628:therapy*; D006801:Humans; D016013:Likelihood Functions; D008390:Markov Chains; D015233:Models, Statistical; D011336:Probability; D013269:Stochastic Processes; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: D000970:Antineoplastic Agents