title: Fractionation, rearrangement and subgenome dominance.
abstract: BACKGROUND
  Fractionation is arguably the greatest cause of gene order disruption following whole genome duplication, causing severe biases in chromosome rearrangement-based estimates of evolutionary divergence.
  
  
  RESULTS
  We show how to correct for this bias almost entirely by means of a 'consolidation' algorithm for detecting and suitably transforming identifiable regions of fractionation. We characterize the process of fractionation and the performance of the algorithm through realistic simulations. We apply our method to a number of core eudicot genomes, we and by studying the fractionation regions detected, are able to address topical issues in polyploid evolution.
  
  
  METHODS
  Code for the consolidation algorithm, and sample data, is available at: http://137.122.149.195/Software/Fractionation/fractionation.html
  
  
  BACKGROUND
  sankoff@uottawa.ca.
authors.affiliation: Department of Mathematics and Statistics, University of Ottawa, Ottawa, Canada K1N 6N5. sankoff@uottawa.ca
authors.forename: David
authors.initials: D
authors.lastname: Sankoff
authors.forename: Chunfang
authors.initials: C
authors.lastname: Zheng
mesh_terms: D000465:Algorithms; D019143:Evolution, Molecular; D023061:Gene Order; D016678:Genome; D018745:Genome, Plant; D032107:Populus / Q000235:genetics; D026801:Synteny