title: [Advances in the structure and function of pandemic A/H1N1/2009 influenza virus HA protein].
abstract: Since March 2009, pandemic A/H1N1/2009 influenza virus has been spreading throughout many countries including China. The emerged virus caused great harm to human health and social economy. Hemagglutinin (HA) is the most important viral surface glycoprotein, mainly possessing three kinds of functions: (1) binding to host cell receptor, (2) triggering the fusion between viral envelop and target cell membrane, (3) stimulating the body to generate the neutralizing antibody. Advances in the structure, primary function, evolution and antigenicity of pandemic A/H1N1/2009 influenza virus HA protein are reviewed in this paper.
authors.affiliation: Shandong Center for Disease Control and Prevention, Shandong Provincial Key Laboratory of Disease Control and Prevention, Shandong University Institute for Prevention Medicine, Jinan 250014, China. wenqiang782002@yahoo.com.cn
authors.forename: Wen-Qiang
authors.initials: WQ
authors.lastname: Zhang
authors.forename: Shao-Xia
authors.initials: SX
authors.lastname: Song
authors.forename: Tong-Zhan
authors.initials: TZ
authors.lastname: Wang
mesh_terms: D000818:Animals; D019143:Evolution, Molecular; D019267:Hemagglutinin Glycoproteins, Influenza Virus / Q000737:chemistry* / Q000235:genetics / Q000276:immunology / Q000378:metabolism*; D006801:Humans; D053118:Influenza A Virus, H1N1 Subtype / Q000235:genetics / Q000276:immunology / Q000472:pathogenicity / Q000502:physiology; D007251:Influenza, Human / Q000453:epidemiology* / Q000821:virology; D058873:Pandemics
chemical_list: D019267:Hemagglutinin Glycoproteins, Influenza Virus