title: Association of -607 C/A polymorphism of IL-18 gene (rs1946518) with breast cancer risk in Zahedan, Southeast Iran.
abstract: It is known that interleukin-18 (IL-18) is a proinflammatory cytokine           with dual effects on tumor development and progression. It can increase the           immune defense against tumor cells. Polymorphisms in the IL-18 genes are known           to influence both expression levels and may be associated with outcome of           cancers. This study was aimed to find out the possible association of IL-18           polymorphism at position -607 C/A (rs1946518) with breast cancer in a sample           of Iranian population. We investigated IL-18 rs1946518 polymorphism           on 72 breast cancer patients and 93 cancer free women. Genotyping was done           using amplification refractory mutation system-PCR (ARMS-PCR). We found           no significant differences between breast cancer patients and control subjects           regarding IL-18 rs1946518 polymorphism (χ2=1.78, p=0.411). In conclusion, our           finding showed that IL-18 rs1946518 polymorphism was not associated with breast           cancer in a sample of Iranian population.
authors.affiliation: Genetic of Non-Communicable Disease Research Center, Zahedan University of Medical Sciences, Zahedan, Iran.
authors.forename: M
authors.initials: M
authors.lastname: Taheri
authors.forename: M
authors.initials: M
authors.lastname: Hashemi
authors.forename: E
authors.initials: E
authors.lastname: Eskandari-Nasab
authors.forename: A
authors.initials: A
authors.lastname: Fazaeli
authors.forename: F
authors.initials: F
authors.lastname: Arababi
authors.forename: M
authors.initials: M
authors.lastname: Bahrani-Zeidabadi
authors.forename: G
authors.initials: G
authors.lastname: Bahari
mesh_terms: D000328:Adult; D001943:Breast Neoplasms / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D020382:Interleukin-18 / Q000235:genetics*; D007492:Iran; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide
chemical_list: D020382:Interleukin-18