title: Hypoglycaemia: exercise for the brain?
abstract: Low blood sugar, or hypoglycaemia, is detected by specialised sugar sensing neurones in the brain. However, the detection of hypoglycaemia is blunted after repeated hypoglycaemia and this is a result of adaptive mechanisms kicking in within the brain; mechanisms that resemble the 'training effect' in muscle. These adaptations most likely not only increase the tolerance of the brain to stress, but also perturb the detection of hypoglycaemia, further increasing the likelihood of hypoglycaemia.
authors.affiliation: Division of Cardiovascular and Diabetes Medicine, Medical Research Institute, Ninewells Hospital & Medical School, University of Dundee, Dundee, UK.
authors.forename: Michael
authors.initials: M
authors.lastname: Ashford
authors.forename: Craig
authors.initials: C
authors.lastname: Beall
authors.forename: Rory
authors.initials: R
authors.lastname: McCrimmon
mesh_terms: D001786:Blood Glucose / Q000378:metabolism; D001921:Brain / Q000503:physiopathology*; D001923:Brain Chemistry / Q000502:physiology; D003920:Diabetes Mellitus / Q000378:metabolism; D004734:Energy Metabolism / Q000502:physiology; D006801:Humans; D007003:Hypoglycemia / Q000378:metabolism / Q000503:physiopathology*
chemical_list: D001786:Blood Glucose