title: Cytosolic lipid inclusions formed during infection by viral and bacterial pathogens.
abstract: Lipid inclusions play an important role in several pathological processes. Intracellular bacterial pathogens, such as members of the Mycobacterium and Chlamydia species are able to trigger the formation of lipid-laden foamy macrophages. Lipid droplet accumulation in the host constitutes a reservoir used by the bacilli for long-term persistence. Viruses need lipid droplets as assembly platform. We present the current knowledge about structural, functional and regulatory aspects of lipid inclusions.
authors.affiliation: Department of Gene Regulation and Differentiation, Helmholtz Centre for Infection Research, Inhoffenstrasse 7, Braunschweig, Germany. mst@lionex.de
authors.forename: Matthias
authors.initials: M
authors.lastname: Stehr
authors.forename: Ayssar A
authors.initials: AA
authors.lastname: Elamin
authors.forename: Mahavir
authors.initials: M
authors.lastname: Singh
mesh_terms: D000818:Animals; D002689:Chlamydia / Q000502:physiology; D002690:Chlamydia Infections / Q000378:metabolism / Q000382:microbiology; D003600:Cytosol / Q000378:metabolism; D005487:Foam Cells / Q000382:microbiology*; D054884:Host-Pathogen Interactions; D006801:Humans; D002479:Inclusion Bodies / Q000378:metabolism*; D050356:Lipid Metabolism; D008055:Lipids / Q000737:chemistry* / Q000235:genetics; D008264:Macrophages / Q000382:microbiology*; D009161:Mycobacterium / Q000502:physiology; D009164:Mycobacterium Infections / Q000378:metabolism / Q000382:microbiology; D014777:Virus Diseases / Q000378:metabolism / Q000821:virology
chemical_list: D008055:Lipids