title: Neuropsychological study of patients with obsessive-compulsive disorder and their parents in China: searching for potential endophenotypes.
abstract: OBJECTIVE
  The existence of neuropsychological deficits has been implicated in obsessive-compulsive disorder (OCD), particularly memory, attention, and executive functions. However, few studies have focused on neuropsychological deficits in the relatives of OCD patients. The aim of this study was to investigate cognitive deficits in OCD patients and their parents.
  
  
  METHODS
  Forty patients with OCD, 48 parents of these patients, and 87 healthy controls completed a neuropsychological testing battery.
  
  
  RESULTS
  Both OCD patients and their parents showed impairments in delayed verbal memory and delayed visual memory. Furthermore, they performed worse than healthy controls in problem-solving ability.
  
  
  CONCLUSIONS
  Our study demonstrated familial aggregation of delayed memory deficits and impaired problem-solving ability, which may be the potential neuropsychological endophenotypes of hereditary susceptibility to OCD.
authors.affiliation: Department of Psychiatry, West China Hospital, Sichuan University, Chengdu, 610041, China.
authors.forename: Bin
authors.initials: B
authors.lastname: Li
authors.forename: Jin-Hua
authors.initials: JH
authors.lastname: Sun
authors.forename: Tao
authors.initials: T
authors.lastname: Li
authors.forename: Yan-Chun
authors.initials: YC
authors.lastname: Yang
mesh_terms: D000293:Adolescent; D000328:Adult; D002681:China / Q000453:epidemiology; D058068:Endophenotypes; D005260:Female; D006801:Humans; D008297:Male; D009483:Neuropsychological Tests; D009771:Obsessive-Compulsive Disorder / Q000453:epidemiology / Q000235:genetics* / Q000523:psychology*; D010290:Parents / Q000523:psychology*; D011446:Prospective Studies; D055815:Young Adult