title: Serum 25(OH)D is inversely associated with metabolic syndrome risk profile among urban middle-aged Chinese population.
abstract: BACKGROUND
  Vitamin D deficiency is associated with a variety of chronic metabolic diseases. Limited evidence regarding vitamin D deficiency exists within the Chinese population. The present study aims to examine the association between serum vitamin D concentrations and cardiometabolic risk factors in the young and middle-aged, urban Chinese population
  
  
  METHODS
  The cross-sectional relationships between serum 25-hydroxyvitamin D [25(OH)D] concentrations and indices of adiposity and cardiometabolic risk factors (e.g., body mass index, waist circumference, fasting plasma glucose, etc.) were evaluated in 601 non-diabetic adults.
  
  
  RESULTS
  Vitamin D deficiency or insufficiency was present in 66% of the tested population, and serum 25(OH)D levels were lower in patients who were overweight/obese or suffered metabolic syndrome when compared to individuals of healthy weight without metabolic syndrome (24.08 ± 8.08 vs 31.70 ± 11.77 ng/ml, 21.52 ± 6.9 vs 31.74 ± 10.21 ng/ml respectively). 25(OH)D was inversely associated with waist circumference, fasting glucose, fasting insulin, triglycerides and LDL-cholesterol, and it was positively associated with HDL-cholesterol in a multivariable-adjusted regression model.
  
  
  CONCLUSIONS
  Vitamin D deficiency is common in the young and middle-aged, urban Chinese population, with high prevalence in overweight/obese individuals and patients with metabolic syndrome. Low vitamin D concentration was associated with indices of adiposity and cardiometabolic risk factors. Further studies are warranted to elucidate the cause-effect relation between vitamin D status, obesity and related metabolic disorders.
authors.affiliation: Center for Health management and Policy, Shandong University, Jinan, China.
authors.forename: Xiao
authors.initials: X
authors.lastname: Yin
authors.forename: Qiang
authors.initials: Q
authors.lastname: Sun
authors.forename: Xiuping
authors.initials: X
authors.lastname: Zhang
authors.forename: Yong
authors.initials: Y
authors.lastname: Lu
authors.forename: Chao
authors.initials: C
authors.lastname: Sun
authors.forename: Ying
authors.initials: Y
authors.lastname: Cui
authors.forename: Shaolian
authors.initials: S
authors.lastname: Wang
mesh_terms: D015652:25-Hydroxyvitamin D 2 / Q000097:blood*; D050154:Adiposity; D000328:Adult; D015992:Body Mass Index; D002112:Calcifediol / Q000097:blood*; D002681:China / Q000453:epidemiology; D015331:Cohort Studies; D003430:Cross-Sectional Studies; D005260:Female; D006786:Hospitals, Urban; D006801:Humans; D015994:Incidence; D008297:Male; D024821:Metabolic Syndrome / Q000150:complications* / Q000453:epidemiology; D008875:Middle Aged; D009765:Obesity / Q000150:complications*; D050177:Overweight / Q000150:complications*; D015995:Prevalence; D012307:Risk Factors; D012720:Severity of Illness Index; D014504:Urban Health; D014808:Vitamin D Deficiency / Q000097:blood / Q000150:complications* / Q000453:epidemiology / Q000503:physiopathology
chemical_list: D015652:25-Hydroxyvitamin D 2; D002112:Calcifediol