title: Assessment of inflammatory and oxidative biomarkers in obesity and their associations with body mass index.
abstract: The aim of this study was to evaluate the inflammatory and oxidative biomarkers' levels in obese subjects and their associations with body mass index (BMI), in order to investigate the role of these biomarkers in obesity. Fasting glucose, total cholesterol, HDL cholesterol, LDL cholesterol, triglycerides, apolipoprotein A, apolipoprotein B, albumin, urinary albumin, creatinine, glomerular filtration rate, interleukin-6 (IL-6), nitrate/nitrite (NOx), and ischemia-modified albumin (IMA) were measured in 93 subjects divided according to different BMI. IL-6, urinary albumin, and IMA levels were significantly higher in obese subjects. However, the levels of NOx were significantly lower in this population. Significant correlations between BMI and IL-6 (r = 0.326, P = 0.002), NOx (r = -0.249, P = 0.021), urinary albumin (r = 0.270, P = 0.008), and IMA (r = 0.286, P = 0.005) were reported. We have shown an increase of IL-6, urinary albumin, and IMA combined with lower levels of NOx in obese patients and an association between of these biomarkers with BMI, suggesting a possible interplay of oxidative stress, inflammation, and endothelial dysfunction state in obesity.
authors.affiliation: Laboratório de Pesquisa em Bioquímica Clínica, Departamento de Análises Clínicas e Toxicológicas, Centro de Ciências da Saúde, Universidade Federal de Santa Maria, Avenida Roraima 1000, Prédio 26, Sala 1401, 97105-900, Santa Maria, Rio Grande do Sul, Brazil.
authors.forename: Sílvia Juliane
authors.initials: SJ
authors.lastname: Piva
authors.forename: Etiane
authors.initials: E
authors.lastname: Tatsch
authors.forename: José Antonio Mainardi
authors.initials: JA
authors.lastname: De Carvalho
authors.forename: Guilherme Vargas
authors.initials: GV
authors.lastname: Bochi
authors.forename: Helena
authors.initials: H
authors.lastname: Kober
authors.forename: Thiago
authors.initials: T
authors.lastname: Duarte
authors.forename: Marta Maria Medeiros Frescura
authors.initials: MM
authors.lastname: Duarte
authors.forename: Ivana Beatrice Mânica
authors.initials: IB
authors.lastname: da Cruz
authors.forename: Maria Beatriz
authors.initials: MB
authors.lastname: Moretto
authors.forename: Rafael Noal
authors.initials: RN
authors.lastname: Moresco
mesh_terms: D000419:Albuminuria; D001053:Apolipoproteins / Q000097:blood; D015415:Biomarkers / Q000097:blood*; D001786:Blood Glucose; D015992:Body Mass Index; D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D003404:Creatinine / Q000097:blood; D005260:Female; D005919:Glomerular Filtration Rate; D006801:Humans; D007249:Inflammation / Q000150:complications*; D015850:Interleukin-6 / Q000097:blood; D008297:Male; D008875:Middle Aged; D009569:Nitric Oxide / Q000097:blood; D009765:Obesity / Q000097:blood / Q000150:complications* / Q000503:physiopathology; D018384:Oxidative Stress; D012709:Serum Albumin; D014280:Triglycerides / Q000097:blood
chemical_list: D001053:Apolipoproteins; D015415:Biomarkers; D001786:Blood Glucose; D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D015850:Interleukin-6; D012709:Serum Albumin; D014280:Triglycerides; D009569:Nitric Oxide; D003404:Creatinine