title: Signaling from the podocyte intercellular junction to the actin cytoskeleton.
abstract: Observations of hereditary glomerular disease support the contention that podocyte intercellular junction proteins are essential for junction formation and maintenance. Genetic deletion of most of these podocyte intercellular junction proteins results in foot process effacement and proteinuria. This review focuses on the current understanding of molecular mechanisms by which podocyte intercellular junction proteins such as the nephrin-neph1-podocin-receptor complex coordinate cytoskeletal dynamics and thus intercellular junction formation, maintenance, and injury-dependent remodeling.
authors.affiliation: Renal-Electrolyte and Hypertension Division, University of Pennsylvania, Philadelphia, PA 19104, USA.
authors.forename: Britta
authors.initials: B
authors.lastname: George
authors.forename: Lawrence B
authors.initials: LB
authors.lastname: Holzman
mesh_terms: D008841:Actin Cytoskeleton / Q000378:metabolism*; D000818:Animals; D006801:Humans; D007365:Intercellular Junctions / Q000378:metabolism* / Q000473:pathology; D047908:Intracellular Signaling Peptides and Proteins / Q000378:metabolism; D008565:Membrane Proteins / Q000378:metabolism; D050199:Podocytes / Q000166:cytology / Q000378:metabolism*; D015398:Signal Transduction
chemical_list: D047908:Intracellular Signaling Peptides and Proteins; C431137:KIRREL1 protein, human; D008565:Membrane Proteins; C407223:NPHS2 protein; C113267:nephrin