title: IDH1 mutations disrupt blood, brain, and barriers.
abstract: The first two murine models of IDH1(R132H) mutation provide mechanistic insights into transformation. In hematopoietic cells, inhibition of TET2 and histone demethylases leads to epigenetic alterations and accumulation of hematopoietic precursors. In the central nervous system, inhibition of collagen and prolyl hydroxylases lead to altered microenvironment and defective angiogenesis.
authors.affiliation: Human Oncology and Pathogenesis Program, Leukemia Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
authors.forename: Alan H
authors.initials: AH
authors.lastname: Shih
authors.forename: Ross L
authors.initials: RL
authors.lastname: Levine
mesh_terms: D000818:Animals; D001921:Brain / Q000378:metabolism*; D002471:Cell Transformation, Neoplastic; D044127:Epigenesis, Genetic; D006410:Hematopoiesis; D006412:Hematopoietic Stem Cells / Q000166:cytology* / Q000502:physiology; D006413:Hematopoietic System / Q000502:physiology*; D007521:Isocitrate Dehydrogenase / Q000235:genetics* / Q000378:metabolism*; D051379:Mice; D023421:Models, Animal; D050505:Mutant Proteins / Q000235:genetics / Q000378:metabolism; D009154:Mutation; D009389:Neovascularization, Pathologic; D010641:Phenotype
chemical_list: D050505:Mutant Proteins; D007521:Isocitrate Dehydrogenase