title: Alteration patterns of trabecular bone microarchitectural characteristics induced by osteoarthritis over time.
abstract: Information regarding the alteration of trabecular bone microarchitecture, which is one of the important criteria to estimate bone condition, induced by osteoarthritis (OA) is sparse. The current study therefore aimed to identify and quantify patterns of alterations in trabecular bone microarchitectural characteristics at tibial epiphysis induced by OA using in vivo microcomputed tomography. Fourteen 8-week-old female Sprague Dawley rats were randomly divided into control (n = 7) and OA (n = 7) groups. Rats in the OA group were administered monoiodoacetate into the knee-joint cavity. The tibial joints were scanned by in vivo microcomputed tomography at 0, 4, and 8 weeks after administration. Two-way analysis of variance with Tukey's honestly significant difference post hoc test was carried out for statistical analyses. The results showed that patterns of alterations in the trabecular bone microarchitectural characteristics in the OA group were not different from those in the control group from 0 to 4 weeks (P > 0.05), but differed from 4 to 8 weeks (P < 0.05). In particular, both trabecular bone thickness and trabecular bone separation distributions over time (4-8 weeks) differed significantly (P < 0.05). These findings suggest that the patterns of bone microarchitecture changes brought about by OA should be periodically considered in the diagnosis and management of arthritic symptoms over time. Improved understanding of the alteration pattern on trabecular bone microarchitecture may assist in developing more targeted treatment interventions for OA.
authors.affiliation: Department of Mechanical Engineering, Sejong University, Seoul, South Korea.
authors.forename: Joo Hyung
authors.initials: JH
authors.lastname: Lee
authors.forename: Keyoung Jin
authors.initials: KJ
authors.lastname: Chun
authors.forename: Han Sung
authors.initials: HS
authors.lastname: Kim
authors.forename: Sang Ho
authors.initials: SH
authors.lastname: Kim
authors.forename: Paul
authors.initials: P
authors.lastname: Han
authors.forename: Yongtae
authors.initials: Y
authors.lastname: Jun
authors.forename: Dohyung
authors.initials: D
authors.lastname: Lim
mesh_terms: D000704:Analysis of Variance; D000818:Animals; D001842:Bone and Bones / Q000000981:diagnostic imaging / Q000187:drug effects / Q000473:pathology*; D002358:Cartilage, Articular / Q000000981:diagnostic imaging / Q000187:drug effects; D004195:Disease Models, Animal; D018450:Disease Progression; D005260:Female; D007461:Iodoacetates / Q000494:pharmacology; D010003:Osteoarthritis / Q000139:chemically induced / Q000000981:diagnostic imaging / Q000473:pathology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D055114:X-Ray Microtomography
chemical_list: D007461:Iodoacetates