title: High RSF-1 expression correlates with poor prognosis in patients with gastric adenocarcinoma.
abstract: OBJECTIVE
  To investigate the expression and prognostic significance of RSF-1 in gastric adenocarcinoma.
  
  
  METHODS
  RSF-1 expression was analyzed using immunohistochemical staining on tissue samples from a consecutive series of 287 gastric adenocarcinoma patients who underwent tumor resections between 2003 and 2006.The relationship between RSF-1 expression, clinicopathological factors, and patient survival was investigated.
  
  
  RESULTS
  Immunohistochemical staining indicated that RSF-1 is highly expressed in 52.6% of gastric adenocarcinomas. RSF-1 expression levels were closely associated with tumor size, histological differentiation, tumor stage, and lymph node involvement. Kaplan-Meier survival analysis showed that high RSF-1 expression exhibited a significant correlation with poor prognosis for gastric adenocarcinoma patients. Multivariate analysis revealed that RSF-1 expression is an independent prognostic parameter for the overall survival rate of gastric adenocarcinoma patients.
  
  
  CONCLUSIONS
  Our data suggest that RSF-1 plays an important role in gastric adenocarcinoma progression and that high RSF-1 expression predicts an unfavorable prognosis in gastric adenocarcinoma patients.
authors.affiliation: Department of General Surgery, Jiangyuan Hospital Affiliated to Jiangsu Institute of Nuclear Medicine, Wuxi 214000, China. hubenshun2008@yahoo.com.cn
authors.forename: Ben-Shun
authors.initials: BS
authors.lastname: Hu
authors.forename: Hai-Feng
authors.initials: HF
authors.lastname: Yu
authors.forename: Gao
authors.initials: G
authors.lastname: Zhao
authors.forename: Tian-Zhou
authors.initials: TZ
authors.lastname: Zha
mesh_terms: D000230:Adenocarcinoma / Q000378:metabolism* / Q000401:mortality / Q000556:secondary; D014408:Biomarkers, Tumor / Q000378:metabolism; D002681:China / Q000453:epidemiology; D005260:Female; D005743:Gastrectomy; D006801:Humans; D007150:Immunohistochemistry; D008198:Lymph Nodes / Q000473:pathology; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D009687:Nuclear Proteins / Q000378:metabolism*; D011379:Prognosis; D013274:Stomach Neoplasms / Q000378:metabolism* / Q000401:mortality / Q000473:pathology; D015996:Survival Rate; D015534:Trans-Activators / Q000378:metabolism*
chemical_list: D014408:Biomarkers, Tumor; D009687:Nuclear Proteins; C452851:RSF1 protein, human; D015534:Trans-Activators