title: Effect of cyclin [corrected] D1 (CCND1) gene polymorphism on tumor formation and behavior in patients with prolactinoma.
abstract: The objective of this study was to investigate the effect of G870A gene polymorphism of CCND1 on the formation and behavioral features of prolactinomas. One hundred and thirteen patients with prolactinoma and 108 age and gender matched control were included in the study. The patients were divided into two groups as noninvasive and invasive tumors. CCND1 G870A gene polymorphism was compared in patients/control and invasive/noninvasive groups. A and G allele frequencies were found as 41.7% and 58.3% in the controls, and 61.1% and 38.9% in the patients (p<0.01). Rates of G/G, G/A and A/A genotypes were found as 11.8%, 55.9% and 32.4% in the noninvasive group, and 15.6%, 44.4% and 40.0% in the invasive group, respectively. Differences between patient and control groups were significant but were not between invasive and noninvasive groups in terms of the allele frequencies and genotype distribution. Mean tumor size and serum levels of prolactin at the time of diagnosis and change in these values after the treatment were not found statistically significant in genotype subgroups. CCND1 G870A gene polymorphism may be an important factor in the early stages of the tumor formation. However, it did not affect the features of the tumor.
authors.affiliation: Uludag University, Medical School, Department of Endocrinology and Metabolism, Bursa, Turkey. drcander@gmail.com
authors.forename: Soner
authors.initials: S
authors.lastname: Cander
authors.forename: Erdinç
authors.initials: E
authors.lastname: Ertürk
authors.forename: Mutlu
authors.initials: M
authors.lastname: Karkucak
authors.forename: Ozen
authors.initials: O
authors.lastname: Oz Gül
authors.forename: Orhan
authors.initials: O
authors.lastname: Görükmez
authors.forename: Tahsin
authors.initials: T
authors.lastname: Yakut
authors.forename: Oğuz Kaan
authors.initials: OK
authors.lastname: Unal
authors.forename: Canan
authors.initials: C
authors.lastname: Ersoy
authors.forename: Ercan
authors.initials: E
authors.lastname: Tuncel
authors.forename: Sazi
authors.initials: S
authors.lastname: Imamoğlu
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001483:Base Sequence; D016022:Case-Control Studies; D003430:Cross-Sectional Studies; D019938:Cyclin D1 / Q000235:genetics*; D017931:DNA Primers / Q000235:genetics; D005260:Female; D005787:Gene Frequency; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009361:Neoplasm Invasiveness / Q000235:genetics / Q000473:pathology; D010911:Pituitary Neoplasms / Q000235:genetics* / Q000473:pathology; D020641:Polymorphism, Single Nucleotide; D015175:Prolactinoma / Q000235:genetics* / Q000473:pathology; D011519:Proto-Oncogenes; D012189:Retrospective Studies; D055815:Young Adult
chemical_list: C530104:CCND1 protein, human; D017931:DNA Primers; D019938:Cyclin D1