title: Synthesis, structure and molecular modelling of anionic carbosilane dendrimers.
abstract: Anionic carbosilane dendrimers of generations 1-3 have been synthesized containing carboxylate G(n)X(C(2)H(4)CO(2)Na)(m) and sulfonate G(n)X(C(2)H(4)SO(3)Na)(m) peripheral groups and derived from two different cores, 1,3,5-(HO)(3)C(6)H(3) (X = O(3)) and Si(C(3)H(5))(4) (X = Si). The peripheral anionic groups make these dendrimers water soluble, despite their highly hydrophobic framework. These dendrimers present a net negative charge in water, which was influenced by the pH of the medium. This characteristic was studied by pH titration. Also molecular modeling calculations have been performed to study differences in an aqueous medium between carboxylate and sulfonate dendrimers of different cores. The results obtained were also compared with those obtained from DOSY NMR experiments and zeta-potential measurements.
authors.affiliation: Dpto. de Química Inorgánica, Universidad de Alcalá, Campus Universitario, E-28871 Alcalá de Henares (Madrid), Spain.
authors.forename: Beatriz
authors.initials: B
authors.lastname: Rasines
authors.forename: Javier
authors.initials: J
authors.lastname: Sánchez-Nieves
authors.forename: Massimo
authors.initials: M
authors.lastname: Maiolo
authors.forename: Marek
authors.initials: M
authors.lastname: Maly
authors.forename: Louis
authors.initials: L
authors.lastname: Chonco
authors.forename: José Luis
authors.initials: JL
authors.lastname: Jiménez
authors.forename: M Ángeles
authors.initials: MÁ
authors.lastname: Muñoz-Fernández
authors.forename: F Javier
authors.initials: FJ
authors.lastname: de la Mata
authors.forename: Rafael
authors.initials: R
authors.lastname: Gómez
mesh_terms: D002264:Carboxylic Acids / Q000737:chemistry; D050091:Dendrimers / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D008958:Models, Molecular; D015394:Molecular Structure; D059808:Polyphenols / Q000737:chemistry; D012821:Silanes / Q000737:chemistry*; D012825:Silicon / Q000737:chemistry; D013451:Sulfonic Acids / Q000737:chemistry
chemical_list: D002264:Carboxylic Acids; D050091:Dendrimers; D059808:Polyphenols; D012821:Silanes; D013451:Sulfonic Acids; C504072:carbosilane; D012825:Silicon