title: Kidney transplantation from living donors genetically related or unrelated to the recipients: a single-center analysis.
abstract: Living-donor programs have gradually become an attractive strategy to expand the donor pool for kidney transplantation (KT). Grafts from living-related donors (LRD) display superior function and longer survival than those obtained from cadaveric sources. Recent reports have shown that outcomes from living-unrelated donors (LUD) are not worse than those from LRD. In this study, we evaluated 135 procedures using living donors performed in our center between 1987 and 2010 (LRD: n = 111; LUD: n = 24). Among the LRD, most donors were mothers (n = 61; 54.95%), fathers (n = 25; 22.52%), and sisters (n = 16; 14.41%). The LUD included wives (n = 17; 70.83%) and husbands (n = 7; 29.17%). The mean recipient ages for LRD versus LUD were 26.94 ± 13.51 and 50.04 ± 8.86 years, respectively (P < .0001). The recipient female/male distribution was 33/78 (29.73%/70.27%) for the LRD versus 6/18 (25%/75%) for the LUD group (P = .643). The donor age was 48.79 ± 9 years in LRD and 49.25 ± 8.44 years in LUD (P = .696). The donor female/male distribution was 72/39 (64.86%/35.16%) in LRD and 17/7 (70.83%/29.17%) in LUD (P = .576). The follow up was 123.79 ± 87.87 months (range, 0.91-279.93). Overall patient and graft survivals were 94.1% and 67.6%, respectively. There was no significant difference in patient survival after stratifying for donor type (LRD: 93.9%; LUD: 95.8%; P = .961) or in graft survival after stratifying for donor type (LRD: 63.8%; LUD: 87.8%; P = .124). Entering donor type as an independent variable in a univariate Cox regression, we observed no significance for either recipient (P = .961) or graft survival (P = .142). The results of this study suggest that LUD utilization should be encouraged in KT programs.
authors.affiliation: Department of Surgical Sciences and Integrated Diagnostics (DISC), Organ Transplantation Section, University of Genoa, Genoa, Italy. gregorio.santori@gmail.com
authors.forename: G
authors.initials: G
authors.lastname: Santori
authors.forename: S
authors.initials: S
authors.lastname: Barocci
authors.forename: I
authors.initials: I
authors.lastname: Fontana
authors.forename: M
authors.initials: M
authors.lastname: Bertocchi
authors.forename: A
authors.initials: A
authors.lastname: Tagliamacco
authors.forename: R
authors.initials: R
authors.lastname: Biticchi
authors.forename: U
authors.initials: U
authors.lastname: Valente
authors.forename: A
authors.initials: A
authors.lastname: Nocera
mesh_terms: D000328:Adult; D005190:Family; D005260:Female; D006801:Humans; D007166:Immunosuppressive Agents / Q000494:pharmacology; D016030:Kidney Transplantation; D019520:Living Donors; D008297:Male
chemical_list: D007166:Immunosuppressive Agents