title: Outcomes in women age 40 years and older with cytologically benign endometrial cells.
abstract: OBJECTIVE
  We sought to estimate cytologically benign endometrial cell (CBEC)-associated endometrial hyperplasia and cancer rates, and describe clinical and histologic outcomes.
  
  
  METHODS
  Medical records of women age >40 years with CBEC in 2005 through 2010 were reviewed for clinical characteristics; assessment with endometrial biopsy, ultrasound, or hysteroscopy; and consequent outcomes.
  
  
  RESULTS
  Of 658 women, 281 (42.7%) were assessed: 39.4% of 330 premenopausal, and 46.0% of 328 postmenopausal women. Among these, cancer rate was 3.6% and differed between premenopausal (0.8%) and postmenopausal (6.0%) women (P = .019). Hyperplasia rate was similar in premenopausal (3.9%) and postmenopausal (3.3%) women. Of 20 assessed women with endometrial pathology, 4 (1 premenopausal) women with cancer and 4 (2 premenopausal) women with hyperplasia had no abnormal bleeding.
  
  
  CONCLUSIONS
  Cancer was more common in postmenopausal women with assessed CBEC while hyperplasia was comparably distributed between premenopausal and postmenopausal women. Findings support CBEC assessment regardless of menopausal status or abnormal bleeding.
authors.affiliation: Department of Obstetrics and Gynecology, Mayo Clinic, Rochester, MN 55905, USA. Casey.petra@mayo.edu
authors.forename: Petra M
authors.initials: PM
authors.lastname: Casey
authors.forename: Mary M
authors.initials: MM
authors.lastname: Gallenberg
authors.forename: Thomas M
authors.initials: TM
authors.lastname: Kastner
authors.forename: Brigitte A
authors.initials: BA
authors.lastname: Barrette
authors.forename: Paula D M
authors.initials: PD
authors.lastname: Chantigian
authors.forename: Lynne T
authors.initials: LT
authors.lastname: Shuster
authors.forename: Kathy L
authors.initials: KL
authors.lastname: MacLaughlin
authors.forename: Sumer K
authors.initials: SK
authors.lastname: Allensworth
authors.forename: Amy L
authors.initials: AL
authors.lastname: Weaver
mesh_terms: D000328:Adult; D001706:Biopsy; D004714:Endometrial Hyperplasia / Q000453:epidemiology* / Q000473:pathology*; D016889:Endometrial Neoplasms / Q000453:epidemiology* / Q000473:pathology*; D004717:Endometrium / Q000000981:diagnostic imaging / Q000473:pathology*; D005260:Female; D006801:Humans; D015907:Hysteroscopy; D015994:Incidence; D008875:Middle Aged; D011127:Polyps / Q000000981:diagnostic imaging / Q000453:epidemiology / Q000473:pathology; D017698:Postmenopause; D017697:Premenopause; D016896:Treatment Outcome; D014463:Ultrasonography