title: Clinically significant anti M antibodies--a report of two cases.
abstract: BACKGROUND
  Most anti-M antibodies are not active at 37°C and are thus of no clinical significance. Occasionally these antibodies have a wide thermal range and can lead to hemolytic transfusion reactions or hemolytic disease of the new born.
  
  
  METHODS
  We describe two cases of anti-M antibodies, both of which were clinically significant.
  
  
  RESULTS
  The first case was detected due to crossmatch incompatibility and the second presented as a blood group discrepancy.
  
  
  CONCLUSIONS
  When the antibody is active at 37°C, M antigen negative red cell units should be issued.
authors.affiliation: Department of Transfusion Medicine, Government Medical College and Hospital, Sector-32, Chandigarh 160032, India. docvpsingh@yahoo.co.in
authors.forename: Gagandeep
authors.initials: G
authors.lastname: Kaur
authors.forename: Sabita
authors.initials: S
authors.lastname: Basu
authors.forename: Paramjit
authors.initials: P
authors.lastname: Kaur
authors.forename: Ravneet
authors.initials: R
authors.lastname: Kaur
mesh_terms: D000888:Antibodies, Anti-Idiotypic / Q000097:blood*; D001789:Blood Group Antigens / Q000097:blood*; D002648:Child; D006801:Humans; D007075:Immunoglobulin M / Q000097:blood*; D007223:Infant; D008951:MNSs Blood-Group System / Q000097:blood*; D008297:Male
chemical_list: D000888:Antibodies, Anti-Idiotypic; D001789:Blood Group Antigens; D007075:Immunoglobulin M; D008951:MNSs Blood-Group System