title: Transcription factor-mediated epigenetic reprogramming.
abstract: Input from various signaling pathways in conjunction with specific transcription factors (TFs), noncoding RNAs, and epigenetic modifiers governs the maintenance of cellular identity. Endogenous or exogenous TFs operate within certain boundaries, which are set, in part, by the cell type-specific epigenetic landscape. Ectopic expression of selected TFs can override the cellular identity and induce reprogramming to alternative fates. In this minireview, we summarize many of the classic examples and a large number of recent studies that have taken advantage of TF-mediated reprogramming to produce cell types of biomedical relevance.
authors.affiliation: Department of Stem Cell and Regenerative Biology, Harvard University and Harvard Stem Cell Institute, Cambridge, Massachusetts 02138, USA.
authors.forename: Camille
authors.initials: C
authors.lastname: Sindhu
authors.forename: Payman
authors.initials: P
authors.lastname: Samavarchi-Tehrani
authors.forename: Alexander
authors.initials: A
authors.lastname: Meissner
mesh_terms: D054337:Cell Dedifferentiation; D044127:Epigenesis, Genetic; D006801:Humans; D014157:Transcription Factors / Q000235:genetics / Q000378:metabolism*
chemical_list: D014157:Transcription Factors