title: Relationship between mean platelet volume and coronary blood flow in patients with atrial fibrillation.
abstract: BACKGROUND
  Atrial fibrillation (AF) is associated with impaired coronary flow by means of Thrombolysis in Myocardial Infarction (TIMI) frame count (TFC). Mean platelet volume (MPV) is elevated in patients with AF. In the present study we aimed to investigate the relationship between MPV and TFC in patients with AF in the absence of obstructive coronary artery disease (CAD).
  
  
  METHODS
  This observational study enrolled 185 AF patients and 189 control subjects, all with angiographically documented normal coronary arteries. MPV was measured at baseline and mean TFC was assessed after diagnostic coronary angiography.
  
  
  RESULTS
  The MPV was 9.95±1.32 in the AF group and 9.02±1.16 in the control group (p<0.001). In AF patients, MPV was significantly correlated with mean TFC (r=0.419, p<0.001), AF duration (r=0.407, p<0.001), AF classification (r=0.378, p<0.001), systemic hypertension (r=0.165, p=0.024), diabetes mellitus (r=0.233, p=0.001), left ventricular ejection fraction (r=-0.347, p<0.001), and baseline use of diuretics (r=0.177, p=0.016). In linear regression analysis, mean TFC, left ventricular ejection fraction and diabetes mellitus were found to be independently associated with MPV (p<0.001, p=0.028 and p=0.045 respectively).
  
  
  CONCLUSIONS
  Mean platelet volume seems to be independently associated with coronary blood flow in patients with atrial fibrillation in the absence of obstructive coronary artery disease.
authors.affiliation: Department of Cardiology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China. chongfeng1970@yahoo.com.cn
authors.forename: Chong
authors.initials: C
authors.lastname: Feng
authors.forename: Weiyi
authors.initials: W
authors.lastname: Mei
authors.forename: Chufan
authors.initials: C
authors.lastname: Luo
authors.forename: Ming
authors.initials: M
authors.lastname: Long
authors.forename: Xun
authors.initials: X
authors.lastname: Hu
authors.forename: Yong
authors.initials: Y
authors.lastname: Huang
authors.forename: Yuantao
authors.initials: Y
authors.lastname: Hao
authors.forename: Zhimin
authors.initials: Z
authors.lastname: Du
mesh_terms: D000368:Aged; D001281:Atrial Fibrillation / Q000097:blood* / Q000000981:diagnostic imaging / Q000503:physiopathology*; D001783:Blood Flow Velocity; D001792:Blood Platelets; D017023:Coronary Angiography; D003326:Coronary Circulation; D048909:Diabetes Complications / Q000097:blood / Q000000981:diagnostic imaging / Q000503:physiopathology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D013318:Stroke Volume