title: No effect of polymorphisms in the non-duplicated region of the CHRNA7 gene on sensory gating P50 ratios in patients with schizophrenia and bipolar disorder.
abstract: Previous research has reported that bipolar disorder and schizophrenic patients evidence sensory gating deficits. The use of intermediate phenotypes may facilitate genetic studies. Four single nucleotide polymorphisms (SNPs) located on the non-duplicated region of the alpha-7 nicotinic receptor gene (CHRNA7) were genotyped in 95 healthy subjects, 127 bipolar disorder and 153 schizophrenic patients. We evaluated the association of these polymorphisms with P50 evoked potential measures. Our results do not support a role for the candidate gene in this neurophysiological disturbance.
authors.affiliation: Institute of Psychiatry and Mental Health, Hospital Clínico San Carlos, Martín Lagos, S/N 28040, Madrid, Spain.
authors.forename: José Antonio
authors.initials: JA
authors.lastname: Cabranes
authors.forename: Inés
authors.initials: I
authors.lastname: Ancín
authors.forename: José Luis
authors.initials: JL
authors.lastname: Santos
authors.forename: Eva
authors.initials: E
authors.lastname: Sánchez-Morla
authors.forename: María Ángeles
authors.initials: MÁ
authors.lastname: García-Jiménez
authors.forename: Juan José
authors.initials: JJ
authors.lastname: López-Ibor
authors.forename: Ana
authors.initials: A
authors.lastname: Barabash
mesh_terms: D000328:Adult; D001714:Bipolar Disorder / Q000235:genetics* / Q000503:physiopathology; D005260:Female; D005838:Genotype; D006801:Humans; D008297:Male; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D011978:Receptors, Nicotinic / Q000235:genetics* / Q000502:physiology; D012559:Schizophrenia / Q000235:genetics* / Q000503:physiopathology; D055139:Sensory Gating / Q000235:genetics*; D064569:alpha7 Nicotinic Acetylcholine Receptor
chemical_list: C579167:Chrna7 protein, human; D011978:Receptors, Nicotinic; D064569:alpha7 Nicotinic Acetylcholine Receptor