title: New insights into pre-mRNA processing factor 19: A multi-faceted protein in humans.
abstract: During the dynamic assembly and activation of the spliceosome, human pre-mRNA processing factor 19 (hPrp19) plays a major role alone or as a part of a protein complex. In addition to participating in post-transcriptional regulation of eukaryotic gene, hPrp19 takes part in many physiological events such as ubiquitin-proteasome system, DNA damage response, proliferation and apoptosis. Increasing evidence also indicates a potential role of hPrp19 during oncogenesis, possibly owing to its activity of repressing apoptosis. Together, these studies add a new dimension to our understanding of hPrp19, and we have reason to believe that continuing excavation of this multi-faceted protein may shed light on its roles in human diseases, especially in cancer.
authors.affiliation: Department of Gastroenterology, Zhongshan Hospital, Fudan University, Shanghai 200032, P.R. China.
authors.forename: Jie
authors.initials: J
authors.lastname: Yin
authors.forename: Ji-Min
authors.initials: JM
authors.lastname: Zhu
authors.forename: Xi-Zhong
authors.initials: XZ
authors.lastname: Shen
mesh_terms: D017209:Apoptosis; D049109:Cell Proliferation; D002471:Cell Transformation, Neoplastic / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D004249:DNA Damage; D045643:DNA Repair Enzymes / Q000235:genetics / Q000378:metabolism*; D015972:Gene Expression Regulation, Neoplastic / Q000235:genetics; D006801:Humans; D009363:Neoplasm Proteins / Q000235:genetics / Q000378:metabolism*; D009369:Neoplasms / Q000201:enzymology* / Q000235:genetics / Q000473:pathology; D009687:Nuclear Proteins / Q000235:genetics / Q000378:metabolism*; D046988:Proteasome Endopeptidase Complex / Q000235:genetics / Q000378:metabolism; D000072260:RNA Splicing Factors; D017381:Spliceosomes / Q000235:genetics / Q000378:metabolism*; D025801:Ubiquitin / Q000235:genetics / Q000378:metabolism
chemical_list: D009363:Neoplasm Proteins; D009687:Nuclear Proteins; D000072260:RNA Splicing Factors; D025801:Ubiquitin; D046988:Proteasome Endopeptidase Complex; D045643:DNA Repair Enzymes; C417041:PRPF19 protein, human