title: Aspirin triggered-lipoxin A4 reduces the adhesion of human polymorphonuclear neutrophils to endothelial cells initiated by preeclamptic plasma.
abstract: BACKGROUND
  Preeclampsia is a disorder of pregnancy, characterized by hypertension and proteinuria after 20 weeks of gestation. Here, we evaluated the role of aspirin triggered-lipoxin A(4) (ATL, 15-epi-LXA(4)) on the modulation of the adhesion of human polymorphonuclear neutrophils (PMN) to endothelial cells initiated by preeclamptic plasma.
  
  
  METHODS
  Plasma from preeclamptic, normotensive pregnant, and non-pregnant women were analyzed for factors involved in regulating angiogenesis, inflammation and lipid peroxidation. Plasma from preeclamptic women was added to human umbilical vein endothelial cells, and the adhesion of PMN (incubated with or without ATL) to cells was evaluated.
  
  
  RESULTS
  Preeclampsia was associated with some augmented anti-angiogenic, oxidative and pro-inflammatory markers, as well as increasing human PMN-endothelial cell adhesion. This cell adhesion was reduced when human PMN were incubated with ATL prior to addition to endothelial monolayers.
  
  
  CONCLUSIONS
  Our results are the starting point for further research on the efficacy and rational use of aspirin in preeclampsia.
authors.affiliation: Grupo Reproducción, Facultad de Medicina. Universidad de Antioquia. Medellín, Colombia. auramariagilvilla@gmail.com
authors.forename: A M
authors.initials: AM
authors.lastname: Gil-Villa
authors.forename: L V
authors.initials: LV
authors.lastname: Norling
authors.forename: C N
authors.initials: CN
authors.lastname: Serhan
authors.forename: D
authors.initials: D
authors.lastname: Cordero
authors.forename: M
authors.initials: M
authors.lastname: Rojas
authors.forename: A
authors.initials: A
authors.lastname: Cadavid
mesh_terms: D000293:Adolescent; D000328:Adult; D001241:Aspirin / Q000494:pharmacology*; D002448:Cell Adhesion / Q000187:drug effects*; D002478:Cells, Cultured; D005260:Female; D061307:Human Umbilical Vein Endothelial Cells / Q000166:cytology / Q000187:drug effects / Q000378:metabolism; D006801:Humans; D015227:Lipid Peroxidation / Q000187:drug effects; D044045:Lipoxins / Q000378:metabolism*; D009504:Neutrophils / Q000166:cytology* / Q000187:drug effects / Q000378:metabolism*; D011225:Pre-Eclampsia / Q000097:blood*; D011247:Pregnancy; D055815:Young Adult
chemical_list: D044045:Lipoxins; C040527:lipoxin A4; D001241:Aspirin