title: [Efficacy of diuretics in the treatment of Morbihan's disease: three cases].
abstract: BACKGROUND
  Morbihan's disease (MD), also known as 'persistent facial oedema' or 'rosaceous lymphoedema', is an uncommon facial condition that is difficult to treat. Its cause remains unclear.
  
  
  OBJECTIVE
  We report three new cases of solid persistent facial oedema, which, after treatment with furosemide, showed dramatic improvement.
  
  
  METHODS
  Three men (respectively aged 38, 66 and 76 years) presented Morbihan's disease progressing respectively for 2, 5 and 8 years. These patients presented with facial oedema, mainly affecting the eyelids. The diagnosis of MD was based on clinical and laboratory criteria (after exclusion of other aetiologies such as sarcoidosis, lupus erythematosus, facial demodicidosis and rosacea). After several unsuccessful treatments (tetracyclines, synthetic antimalarials, danazol, systemic steroids and isotretinoin), the patients received diuretics: furosemide (60 mg/d) in two cases and spironolactone 75 mg twice daily for the third patient. The patients were evaluated after 1 month, then every 3 months.
  
  
  RESULTS
  Regression of oedema was complete or almost complete with follow-up of between 1 and 16 years. No adverse effects were reported.
  
  
  CONCLUSIONS
  Treatment of Morbihan's disease remains difficult and empirical. Diuretics may be of value since they help significantly reduce swelling even if they do not definitely cure patients.
authors.affiliation: Service de dermatologie, université de Franche-Comté, CHU Saint-Jacques, Inserm U1098, SFR FED 4234-IBCT, 2, place Saint-Jacques, 25030 Besançon cedex, France.
authors.forename: R
authors.initials: R
authors.lastname: Messikh
authors.forename: C
authors.initials: C
authors.lastname: Try
authors.forename: B
authors.initials: B
authors.lastname: Bennani
authors.forename: P
authors.initials: P
authors.lastname: Humbert
mesh_terms: D000328:Adult; D000368:Aged; D004232:Diuretics / Q000627:therapeutic use*; D004487:Edema / Q000188:drug therapy*; D005145:Face; D005665:Furosemide / Q000627:therapeutic use*; D006801:Humans; D008297:Male
chemical_list: D004232:Diuretics; D005665:Furosemide