title: Surgical excision of endometriomas and ovarian reserve: a systematic review on serum antimüllerian hormone level modifications.
abstract: OBJECTIVE
  To evaluate serum antimüllerian hormone (AMH) level modification after surgical excision of ovarian endometriomas.
  
  
  METHODS
  Systematic review. MEDLINE search from January 1990 to April 2012 using the combination of medical terms endometriosis, endometrioma, endometriotic cyst, and AMH or antimüllerian hormone, MIF or müllerian inhibiting factor. Reference lists of selected studies were checked for additional potential contributions.
  
  
  METHODS
  Not applicable.
  
  
  METHODS
  Women with ovarian endometriomas requiring surgery.
  
  
  METHODS
  Serum AMH level assessment.
  
  
  METHODS
  Serum AMH level modifications.
  
  
  RESULTS
  Eleven articles satisfied our selection criteria. Data pooling were deemed inopportune owing to the heterogeneity of the study designs and of the reported parameters. Nine of 11 studies documented a statistically significant reduction of serum AMH level after surgery. The two studies failing to document this decrease were published by the same study group and partly overlapped. The magnitude of the decline was more evident in women operated on for bilateral endometriomas.
  
  
  CONCLUSIONS
  Evidence deriving from the evaluation of serum AMH level modifications after surgical excision of endometriomas supports a surgery-related damage to ovarian reserve.
authors.affiliation: Fondazione Cà Granda, Ospedale Maggiore Policlinico, Milan, Italy. dadosomigliana@yahoo.it
authors.forename: Edgardo
authors.initials: E
authors.lastname: Somigliana
authors.forename: Nicola
authors.initials: N
authors.lastname: Berlanda
authors.forename: Laura
authors.initials: L
authors.lastname: Benaglia
authors.forename: Paola
authors.initials: P
authors.lastname: Viganò
authors.forename: Paolo
authors.initials: P
authors.lastname: Vercellini
authors.forename: Luigi
authors.initials: L
authors.lastname: Fedele
mesh_terms: D054304:Anti-Mullerian Hormone / Q000097:blood*; D002452:Cell Count / Q000706:statistics & numerical data; D004715:Endometriosis / Q000097:blood* / Q000601:surgery*; D005260:Female; D006801:Humans; D009865:Oocytes / Q000473:pathology*; D010049:Ovarian Diseases / Q000097:blood* / Q000453:epidemiology / Q000601:surgery*; D015995:Prevalence
chemical_list: D054304:Anti-Mullerian Hormone