title: Design of a cellular-uptake-shielding magnetic catcher for cancer cell separation.
abstract: Fluorescent-magnetic-biotargeting multifunctional microcapsules (FMBMMs) are designed and fabricated via layer-by-layer assembly. It is found that the arginine-glycine-aspartate-modified FMBMMs were capable of sensitively detecting and efficiently isolating approximately 80% target cancer cells within 20 min. More importantly, FMBMMs present a general template for identifying and separating multiple types of cancer cells simply by altering the recognition motif.
authors.affiliation: Key Laboratory of Biomedical Polymers of Ministry of Education & Department of Chemistry, Wuhan University, Wuhan 430072, China.
authors.forename: Ya
authors.initials: Y
authors.lastname: Wang
authors.forename: Jing
authors.initials: J
authors.lastname: Zhang
authors.forename: Hui-Zhen
authors.initials: HZ
authors.lastname: Jia
authors.forename: Juan
authors.initials: J
authors.lastname: Yang
authors.forename: Si-Yong
authors.initials: SY
authors.lastname: Qin
authors.forename: Chen-Wei
authors.initials: CW
authors.lastname: Liu
authors.forename: Ren-Xi
authors.initials: RX
authors.lastname: Zhuo
authors.forename: Xian-Zheng
authors.initials: XZ
authors.lastname: Zhang
mesh_terms: D000818:Animals; D019556:COS Cells; D002214:Capsules / Q000138:chemical synthesis*; D002469:Cell Separation / Q000295:instrumentation / Q000379:methods*; D002522:Chlorocebus aethiops; D052203:Ferrosoferric Oxide / Q000737:chemistry; D016650:Fluorescein-5-isothiocyanate; D005456:Fluorescent Dyes; D006367:HeLa Cells; D006801:Humans; D059346:Magnets; D008855:Microscopy, Electron, Scanning; D009842:Oligopeptides / Q000737:chemistry*; D011073:Polyamines / Q000737:chemistry
chemical_list: D002214:Capsules; D005456:Fluorescent Dyes; D009842:Oligopeptides; D011073:Polyamines; C063994:polyallylamine; D016650:Fluorescein-5-isothiocyanate; D052203:Ferrosoferric Oxide