title: Clinical trial of ghrelin synthesis administration for upper GI surgery.
abstract: Appetite and weight loss following gastrectomy or esophagectomy is one of the major problems that affect the postoperative QoL. Ghrelin, mainly secreted from the stomach, is related to appetite, weight gain, and positive energy balance. This hormone level had been shown to become low for a long time after upper GI surgery. The efficacy of ghrelin synthesis administration for postoperative weight loss was investigated from a clinical trial to develop a new strategy for weight gain. In addition to this treatment for appetite and weight loss, we focused on the anti-inflammatory role of ghrelin. For the purpose of controlling postoperative cytokine storm after esophagectomy, this hormone was introduced in the clinical trial. Finally, ghrelin replacement therapy during chemotherapy in patients with esophageal cancer is also presented. Our clinical trials and their results are presented in this chapter.
authors.affiliation: Division of Gastroenterological Surgery, Department of Surgery, Graduate School of Medicine, Osaka University, Osaka, Japan.
authors.forename: Shuji
authors.initials: S
authors.lastname: Takiguchi
authors.forename: Yuichiro
authors.initials: Y
authors.lastname: Hiura
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Miyazaki
authors.forename: Akihiro
authors.initials: A
authors.lastname: Takata
authors.forename: Kohei
authors.initials: K
authors.lastname: Murakami
authors.forename: Yuichiro
authors.initials: Y
authors.lastname: Doki
mesh_terms: D000368:Aged; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage / Q000627:therapeutic use; D001066:Appetite / Q000187:drug effects; D019167:Appetite Stimulants / Q000008:administration & dosage / Q000627:therapeutic use; D004435:Eating / Q000187:drug effects; D016629:Esophagectomy / Q000009:adverse effects; D005260:Female; D005743:Gastrectomy / Q000009:adverse effects; D054439:Ghrelin / Q000008:administration & dosage* / Q000097:blood / Q000378:metabolism* / Q000627:therapeutic use; D020249:Hormone Replacement Therapy / Q000379:methods*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications / Q000188:drug therapy; D013274:Stomach Neoplasms / Q000378:metabolism / Q000601:surgery; D041742:Upper Gastrointestinal Tract / Q000187:drug effects / Q000378:metabolism / Q000601:surgery*; D015431:Weight Loss
chemical_list: D000893:Anti-Inflammatory Agents; D019167:Appetite Stimulants; D054439:Ghrelin