title: [Study on the time course of macular pigment density measurement in patients with a macular hole--clinical course and impact of surgery].
abstract: BACKGROUND
  In a prospective clinical study we examined the course of the optical density of the macular pigment (MPOD) in patients with idiopathic macular holes before and after pars-plana vitrectomy.
  
  
  METHODS
  Of the 26 patients four had macular holes stage 1, six patients had stage 2 or stage 4 holes and ten people had a macular hole stage 3. The surgical procedure consisted always of a standard 3-port pars plana vitrectomy (PPV) with colouring assisted peeling of the internal limiting membrane. The optical density of macular pigment was determined by the 1-wavelength reflection method before pars plana vitrectomy and after macular hole closure.
  
  
  RESULTS
  The macular hole was completely closed in 25 of 26 eyes (96.15 %). This anatomical success is also the basis for a postoperative improvement in the retinal function. In the case of macular holes from stages 3 and 4 the surgery achieved an increase in visual acuity and an increase of the optical density of the the macular pigment. In patients with macular holes stage 2 the visual acuity and the optical density of the macular pigment were reduced after vitrectomy. In the case of stage 1 holes the visual acuity and the volume of macular pigment also were reduced after the operation.
  
  
  CONCLUSIONS
  In the group of stage 4 macular holes there was a significant increase in maximum optical density and volume of macular pigment after successful surgical hole closure, so the functional profit of PPV is very high in these patients. Even in the case of macular holes of stage 3 the PPV effected a functional improvement in the sense of an increase of the optical density of macular pigment. The increase in volume proved to be significant. For macular holes stage 2 the vitrectomy as a therapy option is generally recognised but PPV does not effect positively the height of the optical density of macular pigment. In these patients both the maximum optical density as well as the volume of macular pigment were reduced in the therapeutic course. Whether surgical intervention is indicated in stage 1 is still controversial. Taking into account the development of MPOD the profit from surgery for the patients is very low. This led to a decrease in volume of macular pigment and only a slight increase in maximum optical density after pars plana vitrectomy.
authors.affiliation: Klinik für Augenheilkunde, Universitätsklinikum Jena.
authors.forename: F
authors.initials: F
authors.lastname: Jordan
authors.forename: S
authors.initials: S
authors.lastname: Jentsch
authors.forename: R
authors.initials: R
authors.lastname: Augsten
authors.forename: J
authors.initials: J
authors.lastname: Strobel
authors.forename: J
authors.initials: J
authors.lastname: Dawczynski
mesh_terms: D000368:Aged; D003720:Densitometry; D019773:Epiretinal Membrane / Q000473:pathology* / Q000601:surgery*; D005260:Female; D005451:Fluorescein Angiography; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D009887:Ophthalmoscopy; D011183:Postoperative Complications / Q000175:diagnosis* / Q000503:physiopathology; D011446:Prospective Studies; D012167:Retinal Perforations / Q000145:classification / Q000175:diagnosis* / Q000601:surgery*; D041623:Tomography, Optical Coherence; D014792:Visual Acuity / Q000502:physiology; D014821:Vitrectomy / Q000379:methods*