title: Heritability of ambulatory and beat-to-beat office blood pressure in large multigenerational Arab pedigrees: the 'Oman Family study'.
abstract: OBJECTIVE
  To estimate the heritability of ambulatory blood pressure (BP), heart rate (HR), and beat-to-beat office BP and HR in an isolated, environmentally and genetically homogeneous Omani Arab population.
  
  
  METHODS
  Ambulatory BP measurements were recorded in 1,124 subjects with a mean age of 33.8 ± 16.2 years, using the auscultatory mode of the validated Schiller ambulatory BP Monitor. Beat-to-beat BP and HR were recorded by the Task Force Monitor. Heritability was estimated using quantitative genetic analysis. This was achieved by applying the maximum-likelihood-based variance decomposition method implemented in SOLAR software.
  
  
  RESULTS
  We detected statistically significant heritability estimates for office beat-to-beat, 24-hour, daytime, and sleep HR of 0.31, 0.21, 0.20, and 0.07, respectively. Heritability estimates in the above mentioned conditions for systolic BP (SBP)/diastolic BP (DBP)/mean BP (MBP)were all significant and estimated at 0.19/0.19/0.19, 0.30/0.44/0.41, 0.28/0.38/0.39, and 0.21/0.18/0.20,respectively. Heritability estimates for 24-hour and daytime ambulatory SBP, DBP, and MBP ranged from 0.28 to 0.44, and were higher than the heritability estimates for beat-to-beat recordings and sleep periods,which were estimated within a narrow range of 0.18-0.21.
  
  
  CONCLUSIONS
  In this cohort, because shared environments are common to all, the environmental influence that occurs is primarily due to the variation in non-shared environment that is unique to the individual. We demonstrated significant heritability estimates for both beat-to-beat office and ambulatory BP and HR recordings, but 24-hour and daytime ambulatory heritabilities are higher than those from beat-to-beat resting levels and ambulatory night-time recordings.
authors.affiliation: College of Medicine and Health Sciences, Sultan Qaboos University, Muscat, Sultanate of Oman. salbarwani@squ.edu.om
authors.forename: Sulayma
authors.initials: S
authors.lastname: Albarwani
authors.forename: M Loretto
authors.initials: ML
authors.lastname: Muñoz
authors.forename: V Saroja
authors.initials: VS
authors.lastname: Voruganti
authors.forename: Deepali
authors.initials: D
authors.lastname: Jaju
authors.forename: V Saeed
authors.initials: VS
authors.lastname: Al-Yahyaee
authors.forename: Syed G
authors.initials: SG
authors.lastname: Rizvi
authors.forename: Juan C
authors.initials: JC
authors.lastname: Lopez-Alvarenga
authors.forename: Zahir M
authors.initials: ZM
authors.lastname: Al-Anqoudi
authors.forename: Riad A
authors.initials: RA
authors.lastname: Bayoumi
authors.forename: Anthony G
authors.initials: AG
authors.lastname: Comuzzie
authors.forename: Harold
authors.initials: H
authors.lastname: Snieder
authors.forename: Mohammed O
authors.initials: MO
authors.lastname: Hassan
mesh_terms: D018912:Arabs / Q000235:genetics*; D001794:Blood Pressure / Q000235:genetics*; D005190:Family; D005260:Female; D006339:Heart Rate / Q000235:genetics*; D006801:Humans; D008297:Male; D009850:Oman; D010375:Pedigree