title: Cognitive development from two to ten years after pediatric epilepsy surgery.
abstract: The development of cognitive functions and the sustainability of seizure control between two and ten years after epilepsy surgery were prospectively investigated in 17 children and adolescents. Intelligence quotient remained stable. Learning capacity improved. Verbal memory improved in half of the subjects and declined in half, whereas figurative memory declined in most patients. Working memory improved as did attention regarding sustained attention and impulse control. In contrast, reaction times were longer, and the auditory attention span was shorter. Executive functions were not affected. Six subjects (35%) were seizure free at the 10-year follow-up, and a seizure reduction of more than 75% had been achieved in 13 (76%). Seizure control improved in five and seizures recurred in two subjects between the two- and the 10-year follow-up.
authors.affiliation: Department of Paediatrics, Institute of Clinical Sciences at the Sahlgrenska Academy, Gothenburg University, Gothenburg, Sweden.
authors.forename: Gerd
authors.initials: G
authors.lastname: Viggedal
authors.forename: Ragnhildur
authors.initials: R
authors.lastname: Kristjansdottir
authors.forename: Ingrid
authors.initials: I
authors.lastname: Olsson
authors.forename: Bertil
authors.initials: B
authors.lastname: Rydenhag
authors.forename: Paul
authors.initials: P
authors.lastname: Uvebrant
mesh_terms: D000293:Adolescent; D000328:Adult; D001288:Attention; D002648:Child; D003072:Cognition Disorders / Q000209:etiology* / Q000601:surgery*; D002658:Developmental Disabilities / Q000209:etiology* / Q000601:surgery*; D007174:Disruptive, Impulse Control, and Conduct Disorders / Q000209:etiology / Q000601:surgery; D004827:Epilepsy / Q000150:complications* / Q000601:surgery*; D005260:Female; D006801:Humans; D007360:Intelligence; D008137:Longitudinal Studies; D008297:Male; D008570:Memory, Short-Term / Q000502:physiology; D009483:Neuropsychological Tests; D010372:Pediatrics; D012189:Retrospective Studies; D018709:Statistics, Nonparametric; D016896:Treatment Outcome; D014706:Verbal Learning / Q000502:physiology; D055815:Young Adult