title: Circulating adiponectin levels and their associated factors in young lean healthy Japanese women.
abstract: OBJECTIVE
  The aim of the current study was to investigate circulating adiponectin levels and their associated factors in young lean healthy Japanese women.
  
  
  METHODS
  We recruited 82 healthy Japanese women in their twenties and thirties with their body mass index <25 kg/m(2), and performed anthropometric, sphygmomanometric, and laboratory examinations. Laboratory examinations included adiponectin levels, as well as lipid profiles, glucose, hemoglobin A1c, transaminase, and creatinine levels, from which the glomerular filtration rate was estimated (eGFR).
  
  
  RESULTS
  The median and interquartile range of circulating adiponectin levels were 8.1 (6.2-10.0) µg/ mL. HDL cholesterol levels and eGFR, but not the other examined clinical parameters, were significantly correlated with log-transformed adiponectin levels; their correlation coefficients were 0.323 (p<0.01) and -0.311 (p<0.01), respectively. Statistical significance was still observed even after adjustment for each other (both p= 0.02). In adjusted models, subjects with HDL cholesterol levels ≥80 mg/dL had 1.3 times higher adiponectin levels than those with 40-60 mg/dL, whereas eGFR ≥110 mL/min/1.73m(2) and 60-90 mL/min/1.73m(2) showed a 1.5-fold difference in adiponectin levels.
  
  
  CONCLUSIONS
  Adiponectin levels of young lean healthy Japanese women had significant associations with HDL cholesterol levels and eGFR, even though their HDL cholesterol levels and eGFR were distributed within normal ranges. It seems important to take into account these two variables in evaluating adiponectin levels of these subjects, even if the two variables are within normal ranges.
authors.affiliation: Department of Metabolic Medicine, Osaka University Graduate School of Medicine, Osaka, Japan. takahara@endmet.med.osaka-u.ac.jp
authors.forename: Mitsuyoshi
authors.initials: M
authors.lastname: Takahara
authors.forename: Naoto
authors.initials: N
authors.lastname: Katakami
authors.forename: Ken
authors.initials: K
authors.lastname: Kishida
authors.forename: Hideaki
authors.initials: H
authors.lastname: Kaneto
authors.forename: Tohru
authors.initials: T
authors.lastname: Funahashi
authors.forename: Iichiro
authors.initials: I
authors.lastname: Shimomura
authors.forename: Sai
authors.initials: S
authors.lastname: Matsunaga
authors.forename: Satoko
authors.initials: S
authors.lastname: Kubo
authors.forename: Hideaki
authors.initials: H
authors.lastname: Fukamizu
authors.forename: Akihito
authors.initials: A
authors.lastname: Otsuka
authors.forename: Kikuo
authors.initials: K
authors.lastname: Ichihara
authors.forename: Tadashi
authors.initials: T
authors.lastname: Nakamura
mesh_terms: D052242:Adiponectin / Q000097:blood*; D000328:Adult; D000886:Anthropometry; D001786:Blood Glucose / Q000032:analysis; D003404:Creatinine / Q000097:blood; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D005919:Glomerular Filtration Rate; D006442:Glycated Hemoglobin / Q000032:analysis; D006801:Humans; D008055:Lipids / Q000097:blood; D012016:Reference Values
chemical_list: D052242:Adiponectin; D001786:Blood Glucose; D003404:Creatinine; D006442:Glycated Hemoglobin; D008055:Lipids; C517652:hemoglobin A1c protein, human