title: Regional cerebral blood flow differences in patients with mild cognitive impairment between those who did and did not develop Alzheimer's disease.
abstract: Mild cognitive impairment (MCI) is a heterogeneous condition associated with increased risk of Alzheimer's disease (AD) and other dementias. This study aimed to identify areas of initial hypoperfusion in MCI conversion to AD using technetium (Tc-99m) hexamethylpropyleneamine oxime (TC-99m HMPAO) single photon emission computed tomography (SPECT) to compare baseline cerebral hypoperfusion in converted MCI and non-converted MCI patients and normal controls. Forty-nine MCI patients were recruited for brain magnetic resonance imaging (MRI), detailed neuropsychological testing, Tc-99m HMPAO SPECT, and 1- to 2-year periodic follow-up to monitor progression to dementia status. We processed SPECT images with Statistical Parametric Mapping 8 (SPM8) software and performed voxel-based statistical parametric mapping analysis. Thirty-nine of 49 MCI patients were included in our analysis. Nine patients were diagnosed with conversion to AD, on average 19.0±6.6 months after initial assessment. Compared with normal controls, converted MCI patients demonstrated perfusion deficits in both parahippocampal gyri and right precuneus, and non-converted MCI patients demonstrated hypoperfusion in the left parahippocampal gyrus. Compared with non-converted MCI patients, converted MCI patients demonstrated significant hypoperfusion in both cingulate gyri and right precuneus. Our study suggests that using brain SPECT to identify initial hypoperfusion in patients with MCI may be helpful for predicting MCI patients likely to develop AD.
authors.affiliation: Department of Neurology, Dong-A University College of Medicine, Busan, Republic of Korea. neuropark@dau.ac.kr
authors.forename: Kyung Won
authors.initials: KW
authors.lastname: Park
authors.forename: Hyun Jin
authors.initials: HJ
authors.lastname: Yoon
authors.forename: Do-Young
authors.initials: DY
authors.lastname: Kang
authors.forename: Byeong C
authors.initials: BC
authors.lastname: Kim
authors.forename: Sangyun
authors.initials: S
authors.lastname: Kim
authors.forename: Jae Woo
authors.initials: JW
authors.lastname: Kim
mesh_terms: D000544:Alzheimer Disease / Q000000981:diagnostic imaging*; D001921:Brain / Q000098:blood supply* / Q000000981:diagnostic imaging*; D002545:Brain Ischemia / Q000000981:diagnostic imaging; D002531:Cerebellum / Q000098:blood supply / Q000000981:diagnostic imaging; D060825:Cognitive Dysfunction / Q000000981:diagnostic imaging*; D018450:Disease Progression; D004292:Dominance, Cerebral / Q000502:physiology; D005500:Follow-Up Studies; D006179:Gyrus Cinguli / Q000098:blood supply / Q000000981:diagnostic imaging; D006801:Humans; D007090:Image Interpretation, Computer-Assisted; D021621:Imaging, Three-Dimensional; D008279:Magnetic Resonance Imaging; D009483:Neuropsychological Tests; D020534:Parahippocampal Gyrus / Q000098:blood supply / Q000000981:diagnostic imaging; D010296:Parietal Lobe / Q000098:blood supply / Q000000981:diagnostic imaging; D011237:Predictive Value of Tests; D012016:Reference Values; D012039:Regional Blood Flow / Q000502:physiology; D019690:Technetium Tc 99m Exametazime; D015899:Tomography, Emission-Computed, Single-Photon
chemical_list: D019690:Technetium Tc 99m Exametazime