title: Emergency neurological life support: status epilepticus.
abstract: Patients with prolonged or rapidly recurring convulsions lasting more than 5 min are in status epilepticus (SE) and require immediate resuscitation. Although there are relatively few randomized clinical trials, available evidence and experience suggest that early and aggressive treatment of SE improves patient outcomes, for which reason it was chosen as an Emergency Neurologic Life Support protocol. The current approach to the emergency treatment of SE emphasizes rapid initiation of adequate doses of first line therapy, as well as accelerated second line anticonvulsant drugs and induced coma when these fail, coupled with admission to a unit capable of neurologic critical care and electroencephalography monitoring. This protocol not only will focus on the initial treatment of SE but also review subsequent steps in the protocol once the patient is hospitalized.
authors.affiliation: Division of Neurocritical Care and the Comprehensive Epilepsy Center, Department of Neurology, Columbia University, New York, NY, USA. jc1439@mail.cumc.columbia.edu
authors.forename: Jan
authors.initials: J
authors.lastname: Claassen
authors.forename: Robert
authors.initials: R
authors.lastname: Silbergleit
authors.forename: Scott D
authors.initials: SD
authors.lastname: Weingart
authors.forename: Wade S
authors.initials: WS
authors.lastname: Smith
mesh_terms: D000465:Algorithms; D000927:Anticonvulsants / Q000627:therapeutic use*; D004569:Electroencephalography; D004632:Emergency Medical Services / Q000379:methods; D006801:Humans; D017410:Practice Guidelines as Topic; D013226:Status Epilepticus / Q000188:drug therapy*
chemical_list: D000927:Anticonvulsants