title: A unique complex translocation involving six different chromosomes in a case of childhood acute lymphoblastic leukemia with the Philadelphia chromosome and adverse prognosis.
abstract: Acute lymphoblastic leukemia (ALL) is the most common childhood malignancy. Approximately 84% of cases of ALL are classified as B-precursor ALL, 14% of cases are T-cell and 2% of cases are B-cell (B-)ALL. About one third of B-ALL cases show an abnormal karyotype. Combining data obtained by immunophenotyping, karyotyping and molecular cytogenetic analyses allows for a better understanding of this heterogeneous disease. This study reports an exceptional B-ALL case with a poor prognosis and unique complex chromosomal aberrations not previously observed, i.e., a translocation involving the six chromosomal regions 1q42, 4q21, 4q24, 4q35 (twice), 8q22 and 10p15.3 besides 9q34 and 22q11.2.
authors.affiliation: Molecular Biology and Biotechnology Department, Human Genetics Division, Atomic Energy Commission of Syria, Damascus, Syria.
authors.forename: Walid Al
authors.initials: WA
authors.lastname: Achkar
authors.forename: Abdulsamad
authors.initials: A
authors.lastname: Wafa
authors.forename: Hasmik
authors.initials: H
authors.lastname: Mkrtchyan
authors.forename: Faten
authors.initials: F
authors.lastname: Moassass
authors.forename: Thomas
authors.initials: T
authors.lastname: Liehr