title: Perfusion curve f (t) analysis of breast cancer by contrast-enhanced ultrasonography.
abstract: BACKGROUND
  Imaging the perfusion of contrast media in breast tumors may allow improved diagnosing and treating breast cancer.
  
  
  OBJECTIVE
  To compare the perfusion curve f (t) characteristics of contrast-enhanced ultrasonography in benign and malignant breast tumors.
  
  
  METHODS
  Patients with breast tumors (n = 87) were evaluated with contrast-enhanced ultrasonography and the perfusion curve f (t) parameters were calculated using Sonoliver(®) software to compare analysis (tumor) and reference (normal) tissue areas. Differences between breast and breast tumors were assessed.
  
  
  RESULTS
  Compared to benign tumors, malignant tumors had faster enhancement time and a shorter mean transit time (all P values < 0.05). The intensity of the signal was also greater for malignant compared with benign tumors.
  
  
  CONCLUSIONS
  Perfusion curve f (t) parameter measurements can distinguish differences in vascular flow between malignant and benign breast tumors and may provide a new quantitative indicator of breast tumor.
authors.affiliation: Department of Ultrasound, Tumor Hospital of Shaanxi Province, Xi’an, Shaanxi Province, China. 842068005@qq.com
authors.forename: Liang
authors.initials: L
authors.lastname: Guo
authors.forename: Zhi-Gang
authors.initials: ZG
authors.lastname: Liu
authors.forename: Pei-Hua
authors.initials: PH
authors.lastname: Han
authors.forename: Quan
authors.initials: Q
authors.lastname: Yuan
authors.forename: Yu
authors.initials: Y
authors.lastname: He
authors.forename: Jun
authors.initials: J
authors.lastname: Li
mesh_terms: D000328:Adult; D001943:Breast Neoplasms / Q000000981:diagnostic imaging*; D003287:Contrast Media; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D008875:Middle Aged; D009389:Neovascularization, Pathologic / Q000000981:diagnostic imaging*; D010743:Phospholipids; D012189:Retrospective Studies; D012984:Software; D018709:Statistics, Nonparametric; D013459:Sulfur Hexafluoride; D016217:Ultrasonography, Mammary
chemical_list: D003287:Contrast Media; D010743:Phospholipids; C420843:contrast agent BR1; D013459:Sulfur Hexafluoride