title: Automated texture-based quantification of centrilobular nodularity and centrilobular emphysema in chest CT images.
abstract: OBJECTIVE
  Characterization of smoking-related lung disease typically consists of visual assessment of chest computed tomographic (CT) images for the presence and extent of emphysema and centrilobular nodularity (CN). Quantitative analysis of emphysema and CN may improve the accuracy, reproducibility, and efficiency of chest CT scoring. The purpose of this study was to develop a fully automated texture-based system for the detection and quantification of centrilobular emphysema (CLE) and CN in chest CT images.
  
  
  METHODS
  A novel approach was used to prepare regions of interest (ROIs) within the lung parenchyma for representation by texture features associated with the gray-level run-length and gray-level gap-length methods. These texture features were used to train a multiple logistic regression classifier to discriminate between normal lung tissue, CN or "smoker's lung," and CLE. This classifier was trained and evaluated on 24 and 71 chest CT scans, respectively.
  
  
  RESULTS
  During training, the classifier correctly classified 89% of ROIs depicting normal lung tissue, 74% of ROIs depicting CN, and 95% of ROIs manifesting CLE. When the performance of the classifier in quantifying extent of CN and CLE was evaluated on 71 chest CT scans, 65% of ROIs in smokers without CLE were classified as CN, compared to 31% in nonsmokers (P < .001) and 28% in smokers with CLE (P < .001).
  
  
  CONCLUSIONS
  The texture-based framework described herein facilitates successful discrimination among normal lung tissue, CN, and CLE and can be used for the automated quantification of smoking-related lung disease.
authors.affiliation: Department of Biomedical Engineering, Rutgers, The State University of New Jersey, Piscataway, NJ 08854, USA. srosskam@eden.rutgers.edu
authors.forename: Shoshana B
authors.initials: SB
authors.lastname: Ginsburg
authors.forename: David A
authors.initials: DA
authors.lastname: Lynch
authors.forename: Russell P
authors.initials: RP
authors.lastname: Bowler
authors.forename: Joyce D
authors.initials: JD
authors.lastname: Schroeder
mesh_terms: D000465:Algorithms; D001185:Artificial Intelligence; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010363:Pattern Recognition, Automated / Q000379:methods*; D011656:Pulmonary Emphysema / Q000000981:diagnostic imaging*; D011856:Radiographic Image Enhancement / Q000379:methods; D011857:Radiographic Image Interpretation, Computer-Assisted / Q000379:methods*; D013902:Radiography, Thoracic / Q000379:methods*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D014057:Tomography, X-Ray Computed / Q000379:methods*