title: Age-related Epstein-Barr virus-positive cutaneous ulcer arising after a self-limited subcutaneous abscess: a case report.
abstract: BACKGROUND
  Epstein-Barr virus-positive mucocutaneous ulcer is a newly recognized clinicopathologic entity in the spectrum of Epstein-Barr virus-positive lymphoproliferative disorders. This entity is characterized by a self-limited, indolent course.
  
  
  METHODS
  We report the case of a 74-year-old, type 2 diabetic man who presented with an ulceroinfiltrative skin lesion on the left side of his neck. Histological examination showed that the lesion consisted of large atypical cells, some with Hodgkin-Reed-Sternberg-like morphology, in the midst of reactive lymphocytes, plasma cells, eosinophils and histiocytes. The atypical cells were partially positive for CD45, CD20, CD79a, CD30, B-cell lymphoma 2 and latent membrane protein 1 (CS.1-4), and negative for CD15, B-cell lymphoma 6 and CD10. In situ hybridization for Epstein-Barr virus-encoded ribonucleic acid was positive. Two years before, the patient had been diagnosed with a self-limited subcutaneous abscess in the same anatomic area that healed after antibiotic therapy.
  
  
  CONCLUSIONS
  Older patients with positive Epstein-Barr virus serology may develop B-cell lymphoproliferations due to age-related immune suppression. Epstein-Barr virus-encoded ribonucleic acid testing and clonality analysis, eventually complemented with close clinical follow-up, should be performed for suspicious inflammatory lesions in older patients.
authors.affiliation: Institute of Anatomic Pathology, University Clinical Center of Kosovo, "Rrethi i Spitalit" p,n,10000, Prishtina, Republic of Kosova. fkurshumliu@yahoo.com.
authors.forename: Shemsedin
authors.initials: S
authors.lastname: Sadiku
authors.forename: Fisnik
authors.initials: F
authors.lastname: Kurshumliu
authors.forename: Xhevdet
authors.initials: X
authors.lastname: Krasniqi
authors.forename: Ahmet
authors.initials: A
authors.lastname: Brovina
authors.forename: Emrush
authors.initials: E
authors.lastname: Kryeziu
authors.forename: Ibrahim
authors.initials: I
authors.lastname: Rrudhani
authors.forename: Kastriot
authors.initials: K
authors.lastname: Meqa
authors.forename: Lumturije
authors.initials: L
authors.lastname: Gashi-Luci
authors.forename: Hartmut
authors.initials: H
authors.lastname: Merz