title: Prostate cancer, Version 3.2012: featured updates to the NCCN guidelines.
abstract: The NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines) for Prostate Cancer provide multidisciplinary recommendations for the clinical management of patients with prostate cancer. These NCCN Guidelines Insights highlight notable recent updates. Abiraterone acetate is a first-in-class hormonal agent that represents a new standard of care for patients with metastatic castration-recurrent prostate cancer who have previously received docetaxel (category 1 recommendation). Abiraterone acetate also received category 2B recommendations in the prechemotherapy setting for asymptomatic patients or symptomatic patients who are not candidates for docetaxel. The NCCN Prostate Cancer Panel also added new indications for existing agents, including the option of sipuleucel-T as second-line therapy. In addition, brachytherapy in combination with external beam radiation therapy with or without androgen deprivation therapy is now an alternative for patients with high-risk localized tumors or locally advanced disease.
authors.affiliation: Roswell Park Cancer Institute, James Cancer Hospital and Solove Research Institute, USA.
authors.forename: James L
authors.initials: JL
authors.lastname: Mohler
authors.forename: Andrew J
authors.initials: AJ
authors.lastname: Armstrong
authors.forename: Robert R
authors.initials: RR
authors.lastname: Bahnson
authors.forename: Barry
authors.initials: B
authors.lastname: Boston
authors.forename: J Erik
authors.initials: JE
authors.lastname: Busby
authors.forename: Anthony Victor
authors.initials: AV
authors.lastname: D'Amico
authors.forename: James A
authors.initials: JA
authors.lastname: Eastham
authors.forename: Charles A
authors.initials: CA
authors.lastname: Enke
authors.forename: Thomas
authors.initials: T
authors.lastname: Farrington
authors.forename: Celestia S
authors.initials: CS
authors.lastname: Higano
authors.forename: Eric Mark
authors.initials: EM
authors.lastname: Horwitz
authors.forename: Philip W
authors.initials: PW
authors.lastname: Kantoff
authors.forename: Mark H
authors.initials: MH
authors.lastname: Kawachi
authors.forename: Michael
authors.initials: M
authors.lastname: Kuettel
authors.forename: Richard J
authors.initials: RJ
authors.lastname: Lee
authors.forename: Gary R
authors.initials: GR
authors.lastname: MacVicar
authors.forename: Arnold W
authors.initials: AW
authors.lastname: Malcolm
authors.forename: David
authors.initials: D
authors.lastname: Miller
authors.forename: Elizabeth R
authors.initials: ER
authors.lastname: Plimack
authors.forename: Julio M
authors.initials: JM
authors.lastname: Pow-Sang
authors.forename: Mack
authors.initials: M
authors.lastname: Roach
authors.forename: Eric
authors.initials: E
authors.lastname: Rohren
authors.forename: Stan
authors.initials: S
authors.lastname: Rosenfeld
authors.forename: Sandy
authors.initials: S
authors.lastname: Srinivas
authors.forename: Seth A
authors.initials: SA
authors.lastname: Strope
authors.forename: Jonathan
authors.initials: J
authors.lastname: Tward
authors.forename: Przemyslaw
authors.initials: P
authors.lastname: Twardowski
authors.forename: Patrick C
authors.initials: PC
authors.lastname: Walsh
authors.forename: Maria
authors.initials: M
authors.lastname: Ho
authors.forename: Dorothy A
authors.initials: DA
authors.lastname: Shead
mesh_terms: D000069501:Abiraterone Acetate; D000726:Androgen Antagonists / Q000627:therapeutic use; D000730:Androstadienes / Q000627:therapeutic use; D000970:Antineoplastic Agents / Q000627:therapeutic use; D001918:Brachytherapy; D000077143:Docetaxel; D006801:Humans; D008297:Male; D009919:Orchiectomy; D011471:Prostatic Neoplasms / Q000188:drug therapy / Q000532:radiotherapy / Q000628:therapy*; D043823:Taxoids / Q000627:therapeutic use; D014020:Tissue Extracts / Q000627:therapeutic use
chemical_list: D000726:Androgen Antagonists; D000730:Androstadienes; D000970:Antineoplastic Agents; D043823:Taxoids; D014020:Tissue Extracts; D000077143:Docetaxel; C511774:sipuleucel-T; D000069501:Abiraterone Acetate