title: Vitamin E-coated polysulfone membrane improved red blood cell antioxidant status in hemodialysis patients.
abstract: BACKGROUND
  Oxidative stress has emerged as a strong pathogenic cofactor implicated in the development of long-term complications in hemodialysis (HD) patients, such as anemia, and as a major component of the malnutrition inflammation complex syndrome. This prospective multicenter study aimed at evaluating the short-term effects of the new vitamin E (vitE)-coated polysulfone (PS) membrane (VitabranE) on biocompatibility performances and anemia in HD patients.
  
  
  METHODS
  After a 3-month washout period with a high-flux synthetic dialyzer, 43 HD patients were switched to a vitE-PS dialyzer. Sampling was performed at baseline (corresponding to the end of the washout period) and after 1, 2 and 3 months of treatment. Oxidative stress status, as well as inflammatory parameters, was investigated at the end of each study period. Hemoglobin levels and administered doses of recombinant human erythropoietin or epoetin (EPO) were available in each center.
  
  
  RESULTS
  The use of vitE-coated membranes for 3 months was not associated with any change in inflammatory parameters. By contrast, vitE-PS dialyzer resulted in a progressive increase in red blood cell (RBC) vitE concentration and in RBC superoxide dismutase activity. A concomitant progressive significant decrease in advanced oxidation protein product concentration at 2 months was observed, suggesting a preventive effect on oxidative stress. Finally, a significant decrease of the erythropoietin resistance index was obtained after 3 months of treatment.
  
  
  CONCLUSIONS
  Use of the vitE-PS membrane during a short period improves erythrocyte antioxidant defense mechanisms and seems to lead to a reduction in EPO requirements in HD patients.
authors.affiliation: Biochemistry Laboratory, Montpellier University Hospital, Montpellier, France.
authors.forename: Anne-Sophie
authors.initials: AS
authors.lastname: Bargnoux
authors.forename: Jean-Paul
authors.initials: JP
authors.lastname: Cristol
authors.forename: Isabelle
authors.initials: I
authors.lastname: Jaussent
authors.forename: Lotfi
authors.initials: L
authors.lastname: Chalabi
authors.forename: Pierre
authors.initials: P
authors.lastname: Bories
authors.forename: Jean-Jacques
authors.initials: JJ
authors.lastname: Dion
authors.forename: Patrick
authors.initials: P
authors.lastname: Henri
authors.forename: Martine
authors.initials: M
authors.lastname: Delage
authors.forename: Anne-Marie
authors.initials: AM
authors.lastname: Dupuy
authors.forename: Stéphanie
authors.initials: S
authors.lastname: Badiou
authors.forename: Bernard
authors.initials: B
authors.lastname: Canaud
authors.forename: Marion
authors.initials: M
authors.lastname: Morena
mesh_terms: D000740:Anemia / Q000209:etiology / Q000517:prevention & control; D000975:Antioxidants; D020099:Coated Materials, Biocompatible; D004912:Erythrocytes / Q000187:drug effects* / Q000378:metabolism*; D004921:Erythropoietin / Q000627:therapeutic use; D005260:Female; D006801:Humans; D008297:Male; D008567:Membranes, Artificial; D008875:Middle Aged; D018384:Oxidative Stress / Q000187:drug effects; D011108:Polymers; D011446:Prospective Studies; D006435:Renal Dialysis / Q000009:adverse effects; D013450:Sulfones; D014810:Vitamin E / Q000494:pharmacology*
chemical_list: D000975:Antioxidants; D020099:Coated Materials, Biocompatible; D008567:Membranes, Artificial; D011108:Polymers; D013450:Sulfones; D004921:Erythropoietin; D014810:Vitamin E; C017662:polysulfone P 1700