title: Serum levels of glutathione peroxidase 3 in overweight and obese subjects from central Mexico.
abstract: OBJECTIVE
  Overweight and obesity are considered complex entities in which there are alterations in the concentration of antioxidant enzymes. It has been reported that glutathione peroxidase 3 (GPx3), an extracellular enzyme involved in the reduction of both hydro- and lipoperoxides, shows changes both in gene expression and protein concentration in animal models for type 2 diabetes (T2D) and obesity, but the variability of GPx3 levels in different human populations and under different health conditions are currently unclear. We undertook this study to determine the GPx3 levels in overweight and obese subjects from central Mexico.
  
  
  METHODS
  Biochemical profile (serum glucose, insulin and lipid profile) and GPx3 concentrations were determined in 28 healthy subjects (control) and 133 subjects who were overweight or obese (OW-OB).
  
  
  RESULTS
  The OW-OB group had a higher concentration of triacylglycerides (TAG) compared with the control group (201.2 ± 88.7 vs. 100.3 ± 46.4 mg/dL, p <0.05) and the TAG/high density lipoprotein-cholesterol (HDL-C) index (5.6 ± 2.8 vs. 2.1 ± 1.2, p <0.05), whereas the concentration of HDL-C decreased (38.2 ± 8.7 vs. 50.1 ± 14.5 mg/dL, p <0.05). Serum GPx3 was significantly higher in the OW-OB group than in the control group (175.4 ± 25.4 vs. 143.5 ± 23.1 ng/dL). GPx3 concentration correlated with insulin sensitivity (IS) and the TAG/HDL-C index (Rho = -0.2336 and Rho = 0.2275) (p <0.01).
  
  
  CONCLUSIONS
  The TAG/HDL-C index and serum GPx3 concentration increased in the OW-OB group. In addition, GPx3 had a significant correlation with IS, weight, and the TAG/HDL-C index.
authors.affiliation: Facultad de Medicina, Benemérita Universidad Autónoma de Puebla, Mexico.
authors.forename: Blanca G
authors.initials: BG
authors.lastname: Baez-Duarte
authors.forename: Irma
authors.initials: I
authors.lastname: Zamora-Ginez
authors.forename: Francisco
authors.initials: F
authors.lastname: Mendoza-Carrera
authors.forename: Guadalupe
authors.initials: G
authors.lastname: Ruiz-Vivanco
authors.forename: Enrique
authors.initials: E
authors.lastname: Torres-Rasgado
authors.forename: M Elba
authors.initials: ME
authors.lastname: Gonzalez-Mejia
authors.forename: Alejandra
authors.initials: A
authors.lastname: Garcia-Zapien
authors.forename: Silvia E
authors.initials: SE
authors.lastname: Flores-Martinez
authors.forename: Ricardo
authors.initials: R
authors.lastname: Perez-Fuentes
mesh_terms: D000328:Adult; D015992:Body Mass Index; D008076:Cholesterol, HDL / Q000097:blood; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000378:metabolism; D005260:Female; D005979:Glutathione Peroxidase / Q000097:blood*; D006801:Humans; D007328:Insulin / Q000097:blood; D007333:Insulin Resistance; D008297:Male; D008800:Mexico; D008875:Middle Aged; D009765:Obesity / Q000097:blood* / Q000201:enzymology; D050177:Overweight / Q000097:blood* / Q000201:enzymology
chemical_list: D008076:Cholesterol, HDL; D007328:Insulin; C486484:GPX3 protein, human; D005979:Glutathione Peroxidase