title: Chronic periodontitis and the subsequent risk of trigeminal neuralgia: a 5-year follow-up study.
abstract: OBJECTIVE
  This study set out to explore the possibility that chronic periodontitis (CP) may also be a condition that could potentially result in secondary or symptomatic trigeminal neuralgia (TN) by utilizing a population-based dataset and cohort study design in Taiwan.
  
  
  METHODS
  We included 110,104 subjects with CP in our study cohort, and randomly selected 110,104 subjects without a history of CP as a comparison cohort. We individually tracked each patient in this study for a 5-year period to identify those who received a subsequent diagnosis of TN.
  
  
  RESULTS
  The incidence rate of TN during the 5-year follow-up period was 4.40 (95% CI = 3.87-4.98) per 10,000 person-years for subjects with CP, and 2.60 (95% CI = 2.20-3.05) per 10,000 person-years in comparison subjects. Cox proportional analysis revealed that the adjusted hazard ratio (HR) of TN during the 5-year follow-up period for subjects with CP was 1.65 (95% CI = 1.34-2.03) times higher than that of comparison subjects. However, the study subjects who had undergone a gingivectomy or periodontal flap operation did not have a higher adjusted risk of TN than comparison subjects (HR = 0.93, 95% CI = 0.54-1.61).
  
  
  CONCLUSIONS
  Our study detected a greater risk for TN among patients with CP than matched comparison subjects.
authors.affiliation: School of Public Health, Taipei Medical University, Taipei, Taiwan.
authors.forename: Joseph J
authors.initials: JJ
authors.lastname: Keller
authors.forename: Jau-Jiuan
authors.initials: JJ
authors.lastname: Sheu
authors.forename: Herng-Ching
authors.initials: HC
authors.lastname: Lin
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D016022:Case-Control Studies; D055113:Chronic Periodontitis / Q000453:epidemiology*; D015331:Cohort Studies; D015897:Comorbidity; D005260:Female; D006801:Humans; D015994:Incidence; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D016016:Proportional Hazards Models; D012189:Retrospective Studies; D012307:Risk Factors; D013624:Taiwan / Q000453:epidemiology; D014277:Trigeminal Neuralgia / Q000453:epidemiology*; D055815:Young Adult