title: Renalase, hypertension, and kidney - the discussion continues.
abstract: Hypertension and cardiovascular complications are very common in chronic kidney disease (CKD). Overactivation of sympathetic nervous system is also widely recognized in CKD. Renalase may play an important role in the control of blood pressure (BP) by its regulatory function of catecholamine metabolism. Renalase could be synthesized not only by the kidney but also by cardiomyocytes, liver, and adipose tissue. It probably exerts a hypotensive action, at least in animal models. Whether it metabolizes catecholamines remains to be proved. Another issue that remains to be resolved is the relationship between renalase and renal natriuresis and phosphaturia. In this review, the updated experimental and clinical data on renalase are presented and possible interactions with the endothelium are discussed. Renalase is "a new postulated therapeutic target." Proof of concept studies are needed to define the pathophysiological link between the kidney, sympathetic tone, BP, and cardiovascular complications.
authors.affiliation: Department of Nephrology and Transplantology, Medical University in Bialystok, Bialystok, Poland. jolmal@poczta.onet.pl
authors.forename: Jolanta
authors.initials: J
authors.lastname: Malyszko
authors.forename: Jacek S
authors.initials: JS
authors.lastname: Malyszko
authors.forename: Jacek
authors.initials: J
authors.lastname: Rysz
authors.forename: Michal
authors.initials: M
authors.lastname: Mysliwiec
authors.forename: Vladimir
authors.initials: V
authors.lastname: Tesar
authors.forename: Nomy
authors.initials: N
authors.lastname: Levin-Iaina
authors.forename: Maciej
authors.initials: M
authors.lastname: Banach
mesh_terms: D002318:Cardiovascular Diseases / Q000209:etiology / Q000503:physiopathology; D004298:Dopamine / Q000378:metabolism; D006801:Humans; D006973:Hypertension / Q000503:physiopathology*; D007015:Hypophosphatemia, Familial / Q000503:physiopathology; D007668:Kidney / Q000503:physiopathology*; D008995:Monoamine Oxidase / Q000008:administration & dosage / Q000502:physiology*; D009318:Natriuresis / Q000502:physiology; D011954:Receptors, Dopamine / Q000502:physiology; D051436:Renal Insufficiency, Chronic / Q000150:complications / Q000503:physiopathology*
chemical_list: D011954:Receptors, Dopamine; D008995:Monoamine Oxidase; C521557:renalase; D004298:Dopamine