title: Recurrence of cutaneous necrosis in an infant with probable catastrophic antiphospholipid syndrome.
abstract: We present the case of a 3-month-old child with probable catastrophic antiphospholipid syndrome who, after initial successful management with immunomodulary therapies including rituximab, experienced a cutaneous relapse. This rare event was successfully re-treated with repeated administration of rituximab, supporting its role in the control of this disorder. Dermatologic manifestations may be the main clinical presentation of antiphospholipid syndrome, a possible underdiagnosed but potentially fatal pathology.
authors.affiliation: Department of Pediatric Infectious Diseases and Immunology, Hospital Infantil Virgen del Rocío, Seville, Spain. marisolcl@ono.com
authors.forename: Soledad
authors.initials: S
authors.lastname: Camacho-Lovillo
authors.forename: Jose
authors.initials: J
authors.lastname: Bernabeu-Wittel
authors.forename: Estíbaliz
authors.initials: E
authors.lastname: Iglesias-Jimenez
authors.forename: Doloresm
authors.initials: D
authors.lastname: Falcón-Neyra
authors.forename: Olaf
authors.initials: O
authors.lastname: Neth
mesh_terms: D058846:Antibodies, Monoclonal, Murine-Derived / Q000627:therapeutic use*; D016736:Antiphospholipid Syndrome / Q000188:drug therapy* / Q000276:immunology*; D006801:Humans; D007155:Immunologic Factors / Q000627:therapeutic use*; D007223:Infant; D008297:Male; D009336:Necrosis / Q000188:drug therapy / Q000276:immunology; D000069283:Rituximab; D055502:Secondary Prevention; D012720:Severity of Illness Index; D016896:Treatment Outcome
chemical_list: D058846:Antibodies, Monoclonal, Murine-Derived; D007155:Immunologic Factors; D000069283:Rituximab