title: Nitro-fatty acids as novel electrophilic ligands for peroxisome proliferator-activated receptors.
abstract: Lipid nitration has been observed during oxidative/nitrative stress conditions generating a variety of biomolecules capable of modulating cellular responses. This concept has grown as a result of studies with nitro-derivatives of long-chain unsaturated fatty acids containing a nitroalkene group (nitro-fatty acids). This review focuses on the interactions of nitro-fatty acids with members of the peroxisome proliferator-activated receptors (PPARs) family. These nuclear receptors belong to a superfamily of ligand-activated transcription factors, which serve as sensors of lipophilic molecules and regulate the expression of a set of genes involved in glucose and lipid metabolism. Here we discuss how nitro-fatty acids bind and activate PPARs, including the current knowledge of the molecular interactions and cell signaling events involved as well as their therapeutic potential associated with chronic inflammation and metabolic disorders.
authors.affiliation: Cátedra de Inmunología, Facultad de Ciencias/Química, Universidad de la República, Montevideo, Uruguay.
authors.forename: Ana M
authors.initials: AM
authors.lastname: Ferreira
authors.forename: Lucía
authors.initials: L
authors.lastname: Minarrieta
authors.forename: María
authors.initials: M
authors.lastname: Lamas Bervejillo
authors.forename: Homero
authors.initials: H
authors.lastname: Rubbo
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D017124:Conserved Sequence; D005227:Fatty Acids / Q000737:chemistry / Q000378:metabolism* / Q000502:physiology; D006801:Humans; D008024:Ligands; D008969:Molecular Sequence Data; D009574:Nitro Compounds / Q000737:chemistry / Q000378:metabolism*; D018384:Oxidative Stress; D047492:Peroxisome Proliferator-Activated Receptors / Q000378:metabolism* / Q000502:physiology; D011485:Protein Binding; D015398:Signal Transduction
chemical_list: D005227:Fatty Acids; D008024:Ligands; D009574:Nitro Compounds; D047492:Peroxisome Proliferator-Activated Receptors