title: Arteriolar biomechanics in a rat polycystic ovary syndrome model - effects of parallel vitamin D3 treatment.
abstract: To clarify the effects of dihydrotestosterone (DHT)-induced polycystic ovary syndrome (PCOS) on arteriolar biomechanics in a rat model and the possible modulatory role of vitamin D3.
  
  
  RESULTS
  The PCOS model was induced in female Wistar rats by ten-weeks DHT treatment. Arteriolar biomechanics was tested in arterioles by pressure arteriography in control as well as DHT- and DHT with vitamin D3-treated animals in contracted and passive conditions. Increased wall stress and distensibility as well as increased vascular lumen were detected after DHT treatment. Concomitant vitamin D3 treatment lowered the mechanical load of the arterioles and restored the vascular diameter.
  
  
  CONCLUSIONS
  The hyperandrogenic state resulted in more rigid, less flexible arteriolar walls with increased vascular lumen compared with controls. DHT treatment caused eutrophic remodelling of gracilis arteriole. These prehypertensive alterations caused by chronic DHT treatment were mostly reversed by concomitant vitamin D3 administration.
authors.affiliation: 2nd Department Obstet. Gynecol, Faculty of Medicine, Semmelweis University, Budapest, Hungary.
authors.forename: L
authors.initials: L
authors.lastname: Sára
authors.forename: Gyl
authors.initials: G
authors.lastname: Nádasy
authors.forename: P
authors.initials: P
authors.lastname: Antal
authors.forename: M
authors.initials: M
authors.lastname: Szekeres
authors.forename: A
authors.initials: A
authors.lastname: Monori-Kiss
authors.forename: E M
authors.initials: EM
authors.lastname: Horváth
authors.forename: A M
authors.initials: AM
authors.lastname: Tőkés
authors.forename: G
authors.initials: G
authors.lastname: Masszi
authors.forename: E
authors.initials: E
authors.lastname: Monos
authors.forename: Sz
authors.initials: S
authors.lastname: Várbíró
mesh_terms: D000222:Adaptation, Physiological / Q000502:physiology; D000818:Animals; D001160:Arterioles / Q000187:drug effects* / Q000502:physiology*; D001696:Biomechanical Phenomena / Q000187:drug effects / Q000502:physiology; D002762:Cholecalciferol / Q000494:pharmacology*; D004195:Disease Models, Animal; D004548:Elasticity / Q000502:physiology; D005260:Female; D018482:Muscle, Skeletal / Q000098:blood supply; D011085:Polycystic Ovary Syndrome / Q000188:drug therapy* / Q000503:physiopathology*; D058246:Prehypertension / Q000503:physiopathology / Q000517:prevention & control*; D051381:Rats; D017208:Rats, Wistar; D013314:Stress, Mechanical; D014815:Vitamins / Q000494:pharmacology
chemical_list: D014815:Vitamins; D002762:Cholecalciferol