title: Crystal structure of IFIT2 (ISG54) predicts functional properties of IFITs.
abstract: Interferon carries out its cellular effects, including its antiviral effects, by inducing the synthesis of many new proteins, amongst which is the IFIT (ISG56) family of proteins. The first crystal structure of an IFIT, reported by Yang et al., revealed several functional properties of the protein that may help us to better understand the biological functions of these proteins.
authors.affiliation: Department of Molecular Genetics, Lerner Research Institute, Cleveland Clinic, OH 44195, USA. seng@ccf.org
authors.forename: Ganes C
authors.initials: GC
authors.lastname: Sen
authors.forename: Volker
authors.initials: V
authors.lastname: Fensterl
mesh_terms: D000818:Animals; D051017:Apoptosis Regulatory Proteins; D018360:Crystallography, X-Ray; D006801:Humans; D051379:Mice; D011485:Protein Binding; D017434:Protein Structure, Tertiary; D011506:Proteins / Q000737:chemistry* / Q000378:metabolism*; D012313:RNA / Q000378:metabolism; D016601:RNA-Binding Proteins; D014157:Transcription Factors / Q000737:chemistry / Q000378:metabolism
chemical_list: D051017:Apoptosis Regulatory Proteins; C484289:IFIT2 protein, human; D011506:Proteins; D016601:RNA-Binding Proteins; D014157:Transcription Factors; D012313:RNA