title: c-fos and its Consequences in Pain.
abstract: The discovery that c-fos, a proto-oncogene, has a role in pain, has triggered extensive research on the consequences of c-fos expression. It has been shown that c-fos, through its protein form, FOS, leads to expression of dynorphin gene and subsequently dynorphin protein which is implicated in the development of a pain state. This mini review looks at the properties of c-fos and the consequences of its expression following noxious (painful) stimulation.
authors.affiliation: Department of Physiology, School of Medical Sciences, Universiti Sains Malaysia, 16150 Kubang Kerian, Kelantan, Malaysia.
authors.forename: Asma Hayati
authors.initials: AH
authors.lastname: Ahmad
authors.forename: Zalina
authors.initials: Z
authors.lastname: Ismail