title: Impact of maternally-derived antibodies against Salmonella enterica serovar Typhimurium on the bacterial load in suckling piglets.
abstract: The significance of maternal immunity against non-typhoid Salmonella spp. acquired by piglets via colostrum and milk was evaluated in a Salmonella enterica serovar Typhimurium challenge experiment. Piglets from sows vaccinated with an experimental inactivated vaccine exhibited high levels of serum immunoglobulins G and A against S. Typhimurium 4 days after birth, just prior to experimental oral challenge. The S. Typhimurium load in the ileal and caecal wall of piglets 3 days after experimental inoculation was lower by a 2-log magnitude compared to unvaccinated controls. Such a vaccine, delivering colostral/lactogenic immunity to piglets thus has the potential to reduce the prevalence non-typhoid Salmonella spp. infection.
authors.affiliation: Veterinary Research Institute, Hudcova 70, Brno, Czech Republic. matiasovic@vri.cz
authors.forename: Jan
authors.initials: J
authors.lastname: Matiasovic
authors.forename: Hana
authors.initials: H
authors.lastname: Kudlackova
authors.forename: Karolina
authors.initials: K
authors.lastname: Babickova
authors.forename: Hana
authors.initials: H
authors.lastname: Stepanova
authors.forename: Jiri
authors.initials: J
authors.lastname: Volf
authors.forename: Ivan
authors.initials: I
authors.lastname: Rychlik
authors.forename: Vladimir
authors.initials: V
authors.lastname: Babak
authors.forename: Martin
authors.initials: M
authors.lastname: Faldyna
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D058491:Bacterial Load / Q000662:veterinary; D001428:Bacterial Vaccines / Q000276:immunology*; D002432:Cecum / Q000382:microbiology; D003126:Colostrum / Q000276:immunology; D005260:Female; D007082:Ileum / Q000382:microbiology; D007112:Immunity, Maternally-Acquired; D018928:Immunity, Mucosal; D007070:Immunoglobulin A / Q000097:blood; D007074:Immunoglobulin G / Q000097:blood; D008892:Milk / Q000276:immunology; D012481:Salmonella Infections, Animal / Q000276:immunology* / Q000382:microbiology; D012486:Salmonella typhimurium / Q000276:immunology*; D013552:Swine; D013553:Swine Diseases / Q000276:immunology* / Q000382:microbiology; D015164:Vaccines, Inactivated / Q000276:immunology
chemical_list: D001428:Bacterial Vaccines; D007070:Immunoglobulin A; D007074:Immunoglobulin G; D015164:Vaccines, Inactivated