title: Zebrafish as potential model for developmental neurotoxicity testing: a mini review.
abstract: The zebrafish is a powerful toxicity model; biochemical assays can be combined with observations at a structural and functional level within one individual. This mini review summarises the potency of zebrafish as a model for developmental neurotoxicity screening, and its possibilities to investigate working mechanisms of toxicants. The use of zebrafish in toxicity research can ultimately lead to the refinement or reduction of animal use.
authors.affiliation: TNO, Research group Quality and Safety, Zeist, The Netherlands.
authors.forename: Celine
authors.initials: C
authors.lastname: de Esch
authors.forename: Roderick
authors.initials: R
authors.lastname: Slieker
authors.forename: André
authors.initials: A
authors.lastname: Wolterbeek
authors.forename: Ruud
authors.initials: R
authors.lastname: Woutersen
authors.forename: Didima
authors.initials: D
authors.lastname: de Groot
mesh_terms: D023401:Animal Use Alternatives; D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects; D004625:Embryo, Nonmammalian / Q000187:drug effects*; D047108:Embryonic Development / Q000187:drug effects*; D009420:Nervous System / Q000187:drug effects* / Q000196:embryology; D018675:Toxicity Tests / Q000379:methods*; D015027:Zebrafish / Q000196:embryology*