title: Determination of the maximal lactate steady state in obese Zucker rats.
abstract: This study aims to identify the maximum lactate steady state (MLSS) in obese rats in order to provide a more effective tool in the exercise training prescription for this important animal model. To make such determination, obese (Zucker, n=5) (390.0±18.8 g) and lean (Wistar, n=5) (227.3±26.2 g) rats were studied. After adaptation of animals to treadmill, the MLSS was determined by using 3 different velocities (10 m.min⁻¹, 12.5 m.min⁻¹ and 15 m.min⁻¹ for Zucker and 15 m.min⁻¹, 20 m.min⁻¹ and 25 m.min⁻¹ for Wistar). The MLSS was defined as the highest blood lactate concentration that increased up to 1 mmol.L⁻¹ during constant exercise. In obese rats, the MLSS was found in a velocity considerably lower than in lean controls (12.5 m.min⁻¹ and 20 m.min⁻¹), respectively (p<0.05). Therefore, the identification of MLSS in obese Zucker rats is an important tool for exercise prescription and evaluation in obese rat models.
authors.affiliation: Physical Education, Catholic University of Brasilia, Taguatinga, Brazil.
authors.forename: J A
authors.initials: JA
authors.lastname: Almeida
authors.forename: B A
authors.initials: BA
authors.lastname: Petriz
authors.forename: C P C
authors.initials: CP
authors.lastname: Gomes
authors.forename: L A O
authors.initials: LA
authors.lastname: Rocha
authors.forename: R W
authors.initials: RW
authors.lastname: Pereira
authors.forename: O L
authors.initials: OL
authors.lastname: Franco
mesh_terms: D015308:Anaerobic Threshold; D000818:Animals; D015415:Biomarkers / Q000097:blood; D005080:Exercise Test; D005260:Female; D019344:Lactic Acid / Q000097:blood*; D009043:Motor Activity / Q000502:physiology*; D009765:Obesity / Q000097:blood / Q000503:physiopathology*; D051381:Rats; D017208:Rats, Wistar; D011924:Rats, Zucker
chemical_list: D015415:Biomarkers; D019344:Lactic Acid