title: Primary surgical treatment of T3 glottic carcinoma: long-term results and decision-making aspects.
abstract: OBJECTIVE
  The aim of this study was to assess the efficacy of primary surgical treatment in the management of T3 glottic carcinomas.
  
  
  METHODS
  Retrospective clinical study.
  
  
  METHODS
  A retrospective evaluation of the records for all patients treated with primary surgery for T3 glottic carcinomas at a tertiary referral center between 1980 and 2005 was carried out. Data for the 5-year disease-specific survival (DSS) were assessed, as well as local control rates in relation to vocal cord immobility, N classification, choice of surgical modality, and adjuvant therapy. Patients who underwent partial laryngectomy were also evaluated in relation to organ preservation and the rate of permanent tracheotomies.
  
  
  RESULTS
  The 5-year DSS in the 120 patients was 78.3%. Positive neck disease was shown to be a significant negative prognostic factor. Organ preservation was achieved in 90.1% of the patients who underwent partial laryngectomy and in 50% of the overall patient group. The occult metastasis rate was 14%.
  
  
  CONCLUSIONS
  Primary surgical treatment is an effective modality against T3 glottic carcinomas. Partial laryngectomy is a reliable method in carefully selected cases. Low complication rates can be expected.
authors.affiliation: Department of Otorhinolaryngology-Head and Neck Surgery, University of Erlangen-Nuremberg, Erlangen, Germany. konstantinos.mantsopoulos@uk-erlangen.de
authors.forename: Konstantinos
authors.initials: K
authors.lastname: Mantsopoulos
authors.forename: Georgios
authors.initials: G
authors.lastname: Psychogios
authors.forename: Christopher
authors.initials: C
authors.lastname: Bohr
authors.forename: Johannes
authors.initials: J
authors.lastname: Zenk
authors.forename: Markus
authors.initials: M
authors.lastname: Kapsreiter
authors.forename: Frank
authors.initials: F
authors.lastname: Waldfahrer
authors.forename: Heinrich
authors.initials: H
authors.lastname: Iro
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003657:Decision Making; D005260:Female; D005858:Germany / Q000453:epidemiology; D005931:Glottis; D006801:Humans; D015994:Incidence; D007822:Laryngeal Neoplasms / Q000401:mortality / Q000473:pathology / Q000601:surgery*; D007825:Laryngectomy / Q000379:methods*; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000453:epidemiology; D009367:Neoplasm Staging; D012189:Retrospective Studies; D015996:Survival Rate / Q000639:trends; D013997:Time Factors