title: Quantum dot-Eu3+ conjugate as a luminescence turn-on sensor for ultrasensitive detection of nucleoside triphosphates.
abstract: We report a conjugate of thioglycolic acid (TGA) capped CdTe quantum dot and Eu(3+) ion (TGA-CdTe QD-Eu(3+)) that can be used as an ultrasensitive luminescence turn-on sensor for nucleoside triphosphates (NTPs). The TGA-CdTe QD-Eu(3+) conjugate is a weakly luminescent species as a result of the strong quenching effect of Eu(3+) ion on the luminescence of TGA-CdTe QDs. The conjugate's luminescence can be readily restored by its reaction with adenosine triphosphate (ATP) and other NTPs, and thus gives an ultrasensitive detection of NTPs, with a detection limit of 2 nM. The sensing mechanism has also been explored, and the effective quenching of TGA-CdTe QDs emission by Eu(3+) ions has been attributed to photoinduced electron transfer (PET). ATP, as the representative of NTPs, can remove Eu(3+) from the surface of TGA-CdTe QDs, leading to restoration of the TGA-CdTe QDs luminescence.
authors.affiliation: The Key Laboratory for Chemical Biology of Fujian Province, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen 361005, China.
authors.forename: Jinqing
authors.initials: J
authors.lastname: Hong
authors.forename: Dejun
authors.initials: D
authors.lastname: Pei
authors.forename: Xiangqun
authors.initials: X
authors.lastname: Guo
mesh_terms: D000255:Adenosine Triphosphate / Q000032:analysis / Q000737:chemistry; D019187:Cadmium Compounds / Q000737:chemistry; D002623:Chemistry Techniques, Analytical / Q000295:instrumentation*; D004579:Electron Transport; D005063:Europium / Q000737:chemistry*; D008163:Luminescent Measurements; D009711:Nucleotides / Q000032:analysis* / Q000737:chemistry*; D045663:Quantum Dots; D013691:Tellurium / Q000737:chemistry; D013864:Thioglycolates / Q000737:chemistry
chemical_list: D019187:Cadmium Compounds; D009711:Nucleotides; D013864:Thioglycolates; D005063:Europium; C017487:2-mercaptoacetate; D000255:Adenosine Triphosphate; D013691:Tellurium; C028337:cadmium telluride