title: Three bioactive sesquiterpene quinones from the Fijian marine sponge of the genus Hippospongia.
abstract: A sesquiterpenoid quinone, epi-ilimaquinone (1), and two sesquiterpene amino quinones, smenospongine (2) and glycinylilimaquinone (3), were isolated from the Fijian marine sponge Hippospongia sp. The structures of these compounds were determined by spectroscopic analysis. Compounds 1 and 3 were reported for the first time in this study from the sponge of the genus Hippospongia. Compound 1 displayed potent cytotoxic activity and showed antibacterial activity against methicillin-resistant Staphylococcus aureus, wild type S. aureus and vancomycin-resistant Enterococcus faecium and displayed antifungal activity against amphotericin-resistant Candida albicans while compounds 2 and 3 showed moderate cytotoxic activity. However, compound 1 did not show appreciable antifungal activity against wild type C. albicans, Cryptococcus neoformans, Aspergillus niger, Penicillium sp., Rhizopus sporangia or Sordaria sp.
authors.affiliation: a Centre for Drug Discovery and Conservation, Institute of Applied Sciences, The University of the South Pacific , Suva , Fiji Islands.
authors.forename: Rohitesh
authors.initials: R
authors.lastname: Kumar
authors.forename: Ramesh
authors.initials: R
authors.lastname: Subramani
authors.forename: William
authors.initials: W
authors.lastname: Aalbersberg
mesh_terms: D000818:Animals; D000935:Antifungal Agents / Q000737:chemistry / Q000494:pharmacology*; D001230:Aspergillus / Q000187:drug effects; D002176:Candida albicans / Q000187:drug effects; D010407:Penicillium / Q000187:drug effects; D011161:Porifera / Q000737:chemistry*; D011809:Quinones / Q000737:chemistry*; D012233:Rhizopus / Q000187:drug effects; D012717:Sesquiterpenes / Q000737:chemistry*
chemical_list: D000935:Antifungal Agents; D011809:Quinones; D012717:Sesquiterpenes