title: Experimental study of antinociceptive potency of dipeptide GB-115 during chemical and thermal stimulation.
abstract: The study examined the antinociceptive potency of dipeptide compound GB-115 (amide N-6-phenylhexanoyl-glycyl-L-tryptophan) during thermal and chemical noxious stimulation of mice. Peroral administration of GB-115 (0.1-20 mg/kg) decreased the incidence of abdominal contractions induced with intraperitoneal acetic acid (0.75%). This effect was comparable to that of sodium diclofenac (20 mg/kg); it was only partially antagonized with naloxone indicating the presence of significant non-opioid component in analgesic effect of GB-115. Ability of this dipeptide to moderate the nociceptive response in tail flick test under a non-selective blockade of the opioid receptors with naloxone and the absence of similar analgesic potency assessed in the hot plate test attest to predominant effect of GB-115 on spinal opioid receptors.
authors.affiliation: V. V. Zakusov Research Institute of Pharmacology, Russian Academy of Medical Sciences, Moscow, Russia. lgkolik@mail.ru
authors.forename: L G
authors.initials: LG
authors.lastname: Kolik
authors.forename: V N
authors.initials: VN
authors.lastname: Zhukov
authors.forename: T A
authors.initials: TA
authors.lastname: Gudasheva
authors.forename: S B
authors.initials: SB
authors.lastname: Seredenin
mesh_terms: D015746:Abdominal Pain / Q000139:chemically induced / Q000188:drug therapy*; D019342:Acetic Acid / Q000633:toxicity; D000284:Administration, Oral; D000700:Analgesics / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D000704:Analysis of Variance; D000818:Animals; D004151:Dipeptides / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D006358:Hot Temperature; D008297:Male; D051379:Mice; D009270:Naloxone; D010147:Pain Measurement; D018709:Statistics, Nonparametric; D013268:Stimulation, Chemical
chemical_list: D000700:Analgesics; D004151:Dipeptides; C520797:GB-115; D009270:Naloxone; D019342:Acetic Acid