title: Dramatic response to inhaled dobesilate in a patient with lung squamous cell cancer.
abstract: The effectiveness of local application, by inhalation, of dobesilate, an inhibitor of fibroblast growth factor signalling, in a patient with squamous cell lung carcinoma is reported. To our knowledge, these are the first published data on the efficacy of dobesilate in the treatment of this disease. The antimitotic, antiangiogenic, proapoptotic and anti-inflammatory activities of dobesilate can be important factors to consider, in explaining the efficacy of the treatment. Dobesilate administration can be a therapeutic option in patients with lung cancer having poor performance status or severe complications.
authors.affiliation: Departamento de Investigación, IRYCIS, Madrid, Spain. pedro.cuevas@hrc.es
authors.forename: Pedro
authors.initials: P
authors.lastname: Cuevas
authors.forename: Antonio
authors.initials: A
authors.lastname: Sueiro
authors.forename: Pilar
authors.initials: P
authors.lastname: Navío
authors.forename: Guillermo
authors.initials: G
authors.lastname: Giménez-Gallego
mesh_terms: D000280:Administration, Inhalation; D000368:Aged; D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D002123:Calcium Dobesilate / Q000008:administration & dosage / Q000627:therapeutic use*; D002294:Carcinoma, Squamous Cell / Q000188:drug therapy* / Q000473:pathology; D006801:Humans; D008168:Lung / Q000473:pathology; D008175:Lung Neoplasms / Q000188:drug therapy* / Q000473:pathology; D008297:Male
chemical_list: D000970:Antineoplastic Agents; D002123:Calcium Dobesilate