title: Objective and subjective in vivo comparison of two emollient products.
abstract: BACKGROUND
  Few studies have directly compared the effectiveness of different emollients in vivo, and the important matter of patient preference is generally overlooked.
  
  
  METHODS
  We report the results of an assessor-blinded, bilateral, concurrent comparison of two emollient pharmaceutical presentations, ie, Doublebase gel (DB) and Aqueous cream BP (AC), applied by 20 participants three times daily for 7 consecutive days. The primary efficacy endpoint was cumulative improvement in skin hydration measured by corneometry on days 1, 3, and 5 immediately before the first application and approximately 2 hours after the third application of the day. Secondary endpoints were investigator assessment of skin condition at these time points and participant assessment of product acceptability at the end of the study.
  
  
  RESULTS
  Both products increased skin hydration, but the effect of AC was relatively modest, with morning values readily returning to pretreatment levels. Hydration levels were higher for DB gel, maintained at all time points, and showed stepwise, cumulative increases over the 7 days of use. Overall patient satisfaction scores were higher for DB gel, and especially for "consistency," "ease of use," and "ease of absorption into the skin." Eighty-five percent of participants expressed a desire to use DB gel again as compared with 40% for AC.
authors.affiliation: Research and Development Department, Dermal Laboratories Ltd, Hitchin.
authors.forename: Jasmina
authors.initials: J
authors.lastname: Djokic-Gallagher
authors.forename: Phil
authors.initials: P
authors.lastname: Rosher
authors.forename: Jennine
authors.initials: J
authors.lastname: Walker
authors.forename: Valerie
authors.initials: V
authors.lastname: Hart