title: The distinct contributions of fitness and genetic barrier to the development of antiviral drug resistance.
abstract: The selection of resistance to antiviral drugs depends on multiple parameters, including the genetic barrier that is often broadly defined as the number of mutations required to overcome drug selective pressure. In this review, it is intended to assess the roles of genetic barrier and viral fitness at various stages of the selection process. Several examples in the fields of HIV and HCV drug resistance show that the two parameters are distinct and independent. An analogy to the concept of kinetic versus thermodynamic control of chemical reactions supports a more narrow definition of the genetic barrier as the kinetic obstacle for the generation of genetic changes required to overcome selective pressure.
authors.affiliation: Department of Microbiology & Immunology, McGill University, 3775 University Street, Montreal, Quebec H3A 2B4, Canada. matthias.gotte@mcgill.ca
authors.forename: Matthias
authors.initials: M
authors.lastname: Götte
mesh_terms: D000818:Animals; D000998:Antiviral Agents / Q000494:pharmacology*; D055808:Drug Discovery; D024882:Drug Resistance, Viral; D015658:HIV Infections / Q000188:drug therapy* / Q000821:virology; D015497:HIV-1 / Q000187:drug effects / Q000235:genetics* / Q000502:physiology; D016174:Hepacivirus / Q000187:drug effects / Q000235:genetics* / Q000502:physiology; D006526:Hepatitis C / Q000188:drug therapy* / Q000821:virology; D006801:Humans
chemical_list: D000998:Antiviral Agents