title: S1P1 bridges mechanotransduction and angiogenesis during vascular development.
abstract: Mechanisms of stabilization of the vascular plexus and the role of mechanotransduction in this process are not well understood. In this issue of Developmental Cell, Jung et al. (2012) and Gaengel et al. (2012) describe the ligand-sensitive and mechanosensitive functions of an important vascular G protein-coupled receptor, S1P1.
authors.affiliation: Department of Cell Biology and Physiology, McAllister Heart Institute, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
authors.forename: Christopher
authors.initials: C
authors.lastname: Givens
authors.forename: Ellie
authors.initials: E
authors.lastname: Tzima