title: Prenylated phloroglucinol derivatives from Hypericum sampsonii.
abstract: Six new acylphloroglucinol derivatives, sampsonols A-F (1-6), were isolated from the petroleum ether extract of the aerial parts of Hypericum sampsonii. The structures and relative configurations of sampsonols A-F were elucidated by extensive spectroscopic analyses. All these compounds were tested for their in vitro cytotoxic and anti-inflammatory activities. Sampsonols A and B (1 and 2) showed significant cytotoxicity against four human tumor cell lines with IC(50) values in the range of 13-28μM, whereas sampsonols C and F (3 and 6) showed potent inhibitory activities against LPS-induced NO production in RAW 264.7 macrophages with IC(50) values of 27.3 and 29.3μM, respectively.
authors.affiliation: Department of Pharmacognosy, School of Pharmacy, Second Military Medical University, 325 Guohe Road, Shanghai 200433, PR China.
authors.forename: Wen-bo
authors.initials: WB
authors.lastname: Xin
authors.forename: Xiao-hua
authors.initials: XH
authors.lastname: Man
authors.forename: Cheng-jian
authors.initials: CJ
authors.lastname: Zheng
authors.forename: Min
authors.initials: M
authors.lastname: Jia
authors.forename: Yi-ping
authors.initials: YP
authors.lastname: Jiang
authors.forename: Xiang-xiang
authors.initials: XX
authors.lastname: Zhao
authors.forename: Gui-lin
authors.initials: GL
authors.lastname: Jin
authors.forename: Zhu-jun
authors.initials: ZJ
authors.lastname: Mao
authors.forename: Hai-qiu
authors.initials: HQ
authors.lastname: Huang
authors.forename: Lu-ping
authors.initials: LP
authors.lastname: Qin
mesh_terms: D000893:Anti-Inflammatory Agents / Q000737:chemistry / Q000494:pharmacology; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000494:pharmacology; D045744:Cell Line, Tumor; D006801:Humans; D020902:Hypericum / Q000737:chemistry*; D008264:Macrophages / Q000187:drug effects; D008958:Models, Molecular; D015394:Molecular Structure; D010696:Phloroglucinol / Q000031:analogs & derivatives* / Q000737:chemistry*; D018515:Plant Leaves / Q000737:chemistry; D018547:Plant Stems / Q000737:chemistry
chemical_list: D000893:Anti-Inflammatory Agents; D000972:Antineoplastic Agents, Phytogenic; D010696:Phloroglucinol