title: What We Know about the Molecular Genetics of Central Nervous System (CNS) Tumours in Malaysia.
abstract: The new millennium has been regarded as a genomic era. A lot of researchers and pathologists are beginning to understand the scientific basis of molecular genetics and relates with the progression of the diseases. Central nervous system (CNS) tumours are among the most rapidly fatal of all cancers. It has been proposed that the progression of malignant tumours may result from multi-step of genetic alterations, including activation of oncogenes, inactivation of tumour suppressor genes and also the presence of certain molecular marker such as telomerase activity. In this paper, we review some recent data from the literature, including our own studies, on the molecular genetics analysis in CNS tumours. Our studies have shown that two types of tumour suppressor genes, p53 and PTEN were involved in the development of these tumours but not in p16 gene among the patients from Hospital Universiti Sains Malaysia (HUSM). Telomerase activity also has been detected in various types of CNS tumours. Thus, it is important to assemble all data which related to this study and may provide as a vital information in a new approach to neuro-oncology studies in Malaysia.
authors.affiliation: Human Genome Center, Department of Neurosciences.
authors.forename: Sarina
authors.initials: S
authors.lastname: Sulong
authors.forename: Abdul Aziz Mohamed
authors.initials: AA
authors.lastname: Yusoff
authors.forename: Norafiza
authors.initials: N
authors.lastname: Zainuddin
authors.forename: Jafri Malin
authors.initials: JM
authors.lastname: Abdullah
authors.forename: Jain George
authors.initials: JG
authors.lastname: Pannatil
authors.forename: Hasnan
authors.initials: H
authors.lastname: Jaafar
authors.forename: Mohd Nizam
authors.initials: MN
authors.lastname: Isa