title: Synthesis and protective effect of scutellarein on focal cerebral ischemia/reperfusion in rats.
abstract: Scutellarein, the main metabolite of scutellarin in vivo, has relatively better solubility, bioavailability and bio-activity than scutellarin. However, compared with scutellarin, it is very difficult to obtain scutellarein from Nature. Therefore, the present study focused on establishing an efficient route for the synthesis of scutellarein by hydrolyzing scutellarin. Neurological deficit score and cerebral infarction volume with the administration of scutellarein were then used to compare its neuroprotective effects on focal cerebral ischemia/reperfusion in rats induced by middle cerebral artery occlusion (MCAO) with those of scutellarin. The results showed that scutellarein had better protective effect on focal cerebral ischemia/reperfusion than scutellarin, which laid the foundation for further research and development of scutellarein as a promising candidate for ischemic cerebro-vascular disease.
authors.affiliation: Jiangsu Key Laboratory for High Technology Research of TCM Formulae, Nanjing University of Chinese Medicine, Nanjing 210046, China.
authors.forename: Lihua
authors.initials: L
authors.lastname: Qian
authors.forename: Minzhe
authors.initials: M
authors.lastname: Shen
authors.forename: Hao
authors.initials: H
authors.lastname: Tang
authors.forename: Yuping
authors.initials: Y
authors.lastname: Tang
authors.forename: Li
authors.initials: L
authors.lastname: Zhang
authors.forename: Yifan
authors.initials: Y
authors.lastname: Fu
authors.forename: Qianping
authors.initials: Q
authors.lastname: Shi
authors.forename: Nian-Guang
authors.initials: NG
authors.lastname: Li
mesh_terms: D000818:Animals; D047310:Apigenin / Q000138:chemical synthesis* / Q000378:metabolism / Q000494:pharmacology*; D002545:Brain Ischemia / Q000188:drug therapy*; D005965:Glucuronates / Q000378:metabolism / Q000494:pharmacology*; D020244:Infarction, Middle Cerebral Artery / Q000188:drug therapy*; D018696:Neuroprotective Agents / Q000494:pharmacology; D051381:Rats; D015427:Reperfusion Injury / Q000188:drug therapy
chemical_list: D005965:Glucuronates; D018696:Neuroprotective Agents; C484876:scutellarin; D047310:Apigenin; C458179:scutellarein