title: Anti-inflammatory constituents from Tabebuia avellanedae.
abstract: Five novel compounds were isolated from the water extract of Tabebuia avellanedae, and their structures were established by analysis of NMR spectroscopy and mass spectrometry. Compounds 1-5 at 25μM showed strong inhibitory activity on the inflammatory cytokine, tumor-necrosis factor-α and interleukin-1β production in cultured human myeloma THP-1 cells co-stimulated with lipopolysaccharide without any significant cytotoxicity, and their anti-allergic and antioxidant activities were evaluated.
authors.affiliation: Department of Pharmacognosy and Chemistry of Natural Products, Faculty of Pharmaceutical Sciences, Kanazawa University, Kakuma-machi, Kanazawa 920-1192, Japan. suomaorong@163.com
authors.forename: Maorong
authors.initials: M
authors.lastname: Suo
authors.forename: Hasegawa
authors.initials: H
authors.lastname: Isao
authors.forename: Hikaru
authors.initials: H
authors.lastname: Kato
authors.forename: Fumihide
authors.initials: F
authors.lastname: Takano
authors.forename: Tomihisa
authors.initials: T
authors.lastname: Ohta
mesh_terms: D000893:Anti-Inflammatory Agents / Q000737:chemistry* / Q000494:pharmacology*; D001713:Biphenyl Compounds; D002460:Cell Line; D016166:Free Radical Scavengers / Q000494:pharmacology; D005786:Gene Expression Regulation / Q000187:drug effects; D006801:Humans; D053583:Interleukin-1beta / Q000235:genetics / Q000378:metabolism; D015394:Molecular Structure; D010851:Picrates; D010936:Plant Extracts / Q000737:chemistry* / Q000494:pharmacology*; D029663:Tabebuia / Q000737:chemistry*; D014409:Tumor Necrosis Factor-alpha / Q000235:genetics / Q000378:metabolism; D001619:beta-N-Acetylhexosaminidases / Q000235:genetics / Q000378:metabolism
chemical_list: D000893:Anti-Inflammatory Agents; D001713:Biphenyl Compounds; D016166:Free Radical Scavengers; D053583:Interleukin-1beta; D010851:Picrates; D010936:Plant Extracts; D014409:Tumor Necrosis Factor-alpha; C004931:1,1-diphenyl-2-picrylhydrazyl; D001619:beta-N-Acetylhexosaminidases