title: Hepatocellular carcinoma that relapsed 54 months after living donor liver transplantation.
abstract: We report the case of a 41-year-old woman with hepatocellular carcinoma (HCC). She received living donor liver transplantation (LDLT) from her husband for HCC at 36 years of age. She had few risk factors for HCC recurrence, such as elevated alpha-fetoprotein (AFP), protein induced by vitamin K absence (PIVKA) II, vascular invasion, and number, size of tumors. However, recurrent tumors were found in the graft at 54 months after LDLT. Although we examined the sex chromosomes of the HCC by fluorescence in situ hybridization (FISH) methods, the origin of the HCC was unclear. This is a very rare case of recurrent HCC appearing more than 4 years after LDLT in the absence of risk factors for recurrence.
authors.affiliation: Department of Gastroenterology and Rheumatology, Fukushima Medical University School of Medicine, Japan.
authors.forename: Yukiko
authors.initials: Y
authors.lastname: Kanno
authors.forename: Atsushi
authors.initials: A
authors.lastname: Takahashi
authors.forename: Kazumichi
authors.initials: K
authors.lastname: Abe
authors.forename: Toru
authors.initials: T
authors.lastname: Takagi
authors.forename: Ken
authors.initials: K
authors.lastname: Okai
authors.forename: Fumiko
authors.initials: F
authors.lastname: Katsushima
authors.forename: Hironobu
authors.initials: H
authors.lastname: Saito
authors.forename: Takayuki
authors.initials: T
authors.lastname: Anazawa
authors.forename: Takashi
authors.initials: T
authors.lastname: Kimura
authors.forename: Akira
authors.initials: A
authors.lastname: Kenjo
authors.forename: Takao
authors.initials: T
authors.lastname: Tsuchiya
authors.forename: Takuro
authors.initials: T
authors.lastname: Saito
authors.forename: Mitsukazu
authors.initials: M
authors.lastname: Gotoh
authors.forename: Hiromasa
authors.initials: H
authors.lastname: Ohira
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000097:blood; D014408:Biomarkers, Tumor / Q000097:blood; D006528:Carcinoma, Hepatocellular / Q000601:surgery*; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D008113:Liver Neoplasms / Q000601:surgery*; D016031:Liver Transplantation; D009364:Neoplasm Recurrence, Local / Q000097:blood / Q000175:diagnosis* / Q000000981:diagnostic imaging; D011498:Protein Precursors / Q000097:blood; D011516:Prothrombin; D013997:Time Factors; D014057:Tomography, X-Ray Computed
chemical_list: D015415:Biomarkers; D014408:Biomarkers, Tumor; D011498:Protein Precursors; C008208:acarboxyprothrombin; D011516:Prothrombin