title: Molecular aspects of vitamin D anticancer activity.
abstract: Environment may influence the development and prevention of cancer. Calcitriol has been associated with calcium homeostasis regulation. Many epidemiological, biochemical, and genetic studies have shown non-classic effects of vitamin D, such as its involvement in the progression of different cancers. Although vitamin D induces cellular arrest, triggers apoptotic pathways, inhibits angiogenesis, and alters cellular adhesion, the precise mechanisms of its action are still not completely established. This article will present a revision about the molecular aspects proposed to be involved in the anticancer action of calcitriol. Adequate levels of vitamin D to prevent cancer development will also be discussed.
authors.affiliation: Cátedra de Bioquímica y Biología Molecular, Ciencias Médicas, Ciudad Universitaria, Córdoba, Argentina. gpicotto@conicet.gov.ar
authors.forename: Gabriela
authors.initials: G
authors.lastname: Picotto
authors.forename: Ana C
authors.initials: AC
authors.lastname: Liaudat
authors.forename: Luciana
authors.initials: L
authors.lastname: Bohl
authors.forename: Nori
authors.initials: N
authors.lastname: Tolosa de Talamoni
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000378:metabolism / Q000494:pharmacology; D000970:Antineoplastic Agents / Q000378:metabolism* / Q000494:pharmacology; D017209:Apoptosis / Q000187:drug effects; D001343:Autophagy / Q000187:drug effects; D002117:Calcitriol / Q000378:metabolism / Q000494:pharmacology; D020013:Calcium Signaling / Q000187:drug effects; D015815:Cell Adhesion Molecules / Q000378:metabolism; D002453:Cell Cycle / Q000187:drug effects; D002454:Cell Differentiation / Q000187:drug effects; D006801:Humans; D009369:Neoplasms / Q000235:genetics* / Q000378:metabolism* / Q000517:prevention & control; D018919:Neovascularization, Physiologic / Q000187:drug effects; D011110:Polymorphism, Genetic; D017382:Reactive Oxygen Species / Q000378:metabolism; D018167:Receptors, Calcitriol / Q000235:genetics; D014807:Vitamin D / Q000378:metabolism* / Q000494:pharmacology
chemical_list: D000893:Anti-Inflammatory Agents; D000970:Antineoplastic Agents; D015815:Cell Adhesion Molecules; D017382:Reactive Oxygen Species; D018167:Receptors, Calcitriol; D014807:Vitamin D; D002117:Calcitriol