title: Cleft-like formation of the aortic valve in an adult patient with a single coronary artery.
abstract: A 51-year-old woman was admitted to our hospital with heart failure due to aortic regurgitation. Examination showed severe aortic regurgitation mainly due to cleft-like deformity of the right coronary cusp and single coronary artery. Aortic valve replacement was performed, and the deformity was seen in all aortic cusps. Histological study showed elongation of the leaflets by myofibrotic and fibrotic hyperplasia without calcification and inflammation in the aortic valve. This deformity likely arose from an acquired modification of a congenitally malformed aortic valve.
authors.affiliation: Department of Cardiovascular Medicine, Nagasaki University Graduate School of Biomedical Sciences, Japan. hkawano@nagasaki-u.ac.jp
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Kawano
authors.forename: Tomayoshi
authors.initials: T
authors.lastname: Hayashi
authors.forename: Takako
authors.initials: T
authors.lastname: Minami
authors.forename: Yuji
authors.initials: Y
authors.lastname: Koide
authors.forename: Kiyoyuki
authors.initials: K
authors.lastname: Eishi
authors.forename: Koji
authors.initials: K
authors.lastname: Maemura
mesh_terms: D001021:Aortic Valve / Q000002:abnormalities* / Q000473:pathology; D001022:Aortic Valve Insufficiency / Q000209:etiology / Q000601:surgery; D003330:Coronary Vessel Anomalies / Q000175:diagnosis* / Q000473:pathology; D003331:Coronary Vessels / Q000473:pathology*; D005260:Female; D006330:Heart Defects, Congenital / Q000150:complications / Q000473:pathology; D019918:Heart Valve Prosthesis Implantation; D006801:Humans; D008875:Middle Aged; D016896:Treatment Outcome