title: Temporal lobe epilepsy after refractory status epilepticus: an illustrative case and review of the literature.
abstract: New onset refractory status epilepticus (NORSE) is a relatively newly defined disease entity, where otherwise healthy individuals develop unrelenting seizures that do not respond to conventional anticonvulsant therapy and may require months of therapy with anesthetic drugs. We have described a case of NORSE who subsequently developed mesial temporal lobe sclerosis (MTS) and recurrent temporal lobe seizures. We discuss the possible pathophysiological mechanisms by which refractory seizures may contribute to the development of temporal lobe epilepsy (TLE).
authors.affiliation: Division of Critical Care Medicine, Kingston General Hospital, Queen's University, Kingston, ON, Canada K7L 2V7.
authors.forename: J
authors.initials: J
authors.lastname: Gordon Boyd
authors.forename: Derek B
authors.initials: DB
authors.lastname: Debicki
authors.forename: G Bryan
authors.initials: GB
authors.lastname: Young