title: Pathogenic pore-forming proteins: function and host response.
abstract: Organisms from all kingdoms produce pore-forming proteins, with the best-characterized being of bacterial origin. The last decade of research has revealed that the channels formed by these proteins can be very diverse, thus differentially affecting target cell-membrane permeability and consequent cellular outcome. The responses to these toxins are also extremely diverse due to multiple downstream effects of pore-induced changes in ion balance. Determining the secondary effects of pore-forming toxins is essential to understand their contribution to infection.
authors.affiliation: Ecole Polytechnique Fédérale de Lausanne, Global Health Institute, Station 15, CH-1015 Lausanne, Switzerland.
authors.forename: Mirko
authors.initials: M
authors.lastname: Bischofberger
authors.forename: Ioan
authors.initials: I
authors.lastname: Iacovache
authors.forename: F Gisou
authors.initials: FG
authors.lastname: van der Goot
mesh_terms: D000818:Animals; D001419:Bacteria / Q000378:metabolism; D002463:Cell Membrane Permeability; D054884:Host-Pathogen Interactions; D006801:Humans; D007477:Ions / Q000378:metabolism; D052899:Pore Forming Cytotoxic Proteins / Q000633:toxicity*
chemical_list: D007477:Ions; D052899:Pore Forming Cytotoxic Proteins