title: Enhanced detection of virus particles by nanoisland-based localized surface plasmon resonance.
abstract: In this paper, we investigate localized surface plasmon resonance (SPR) detection based on nanoislands. Theoretical calculation performed with rigorous coupled-wave analysis and analytical transfer matrix method using effective medium theory suggests improvement on nanoislands in the limit of detection and sensitivity over conventional thin film-based SPR detection. Experimental results obtained with non-specific detection of ambient adenovirus confirm the improvement by more than one order of magnitude increase in the limit of detection. The enhancement achieved with nanoislands was explored in connection with efficient overlap between target and near-field distribution produced by nanoislands.
authors.affiliation: School of Electrical and Electronic Engineering, Yonsei Institute of Medical Instruments Technology, Seoul 120-749, Republic of Korea.
authors.forename: Hojeong
authors.initials: H
authors.lastname: Yu
authors.forename: Kyujung
authors.initials: K
authors.lastname: Kim
authors.forename: Kyungjae
authors.initials: K
authors.lastname: Ma
authors.forename: Wonju
authors.initials: W
authors.lastname: Lee
authors.forename: Joung-Woo
authors.initials: JW
authors.lastname: Choi
authors.forename: Chae-Ok
authors.initials: CO
authors.lastname: Yun
authors.forename: Donghyun
authors.initials: D
authors.lastname: Kim
mesh_terms: D000256:Adenoviridae / Q000737:chemistry* / Q000302:isolation & purification*; D015374:Biosensing Techniques / Q000295:instrumentation*; D004867:Equipment Design; D019544:Equipment Failure Analysis; D053758:Nanoparticles / Q000737:chemistry* / Q000648:ultrastructure; D036103:Nanotechnology / Q000295:instrumentation*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D020349:Surface Plasmon Resonance / Q000295:instrumentation*; D014771:Virion / Q000737:chemistry* / Q000302:isolation & purification*