title: T2-weighted and delayed enhancement MRI of eosinophilic myocarditis: relationship with clinical phases and global cardiac function.
abstract: OBJECTIVE
  To evaluate the usefulness of magnetic resonance imaging (MRI) for detection and quantification of myocardial damage related to clinical phases and cardiac function during eosinophilic myocarditis.
  
  
  METHODS
  Four eosinophilic myocarditis patients received seven MRI studies. The left ventricular myocardium was divided into 48 layers, and we quantified the extent of abnormal intensity detected by T2-weighted or delayed enhancement MRI relative to the clinical phase and global cardiac function.
  
  
  RESULTS
  T2-weighted imaging detected extensive myocardial hyperintensity during the acute phase of eosinophilic myocarditis. Diffuse myocardial delayed enhancement was observed in one patient during the acute phase, but not in the other. Little or no hyperintensity was detected by T2-weighted imaging or myocardial delayed enhancement during the convalescent phase. The extent of hyperenhancing myocardial layers was inversely correlated with the ejection fraction (EF) (r = -0.87).
  
  
  CONCLUSIONS
  MRI can evaluate the presence and extent of myocardial damage related to the clinical phases and EF during eosinophilic myocarditis.
authors.affiliation: Department of Radiology, Nippon Medical School, 1-1-5 Sendagi, Bunkyo-ku, Tokyo 113-8603, Japan. h-tsuji@nms.ac.jp
authors.forename: Hitomi
authors.initials: H
authors.lastname: Tani
authors.forename: Yasuo
authors.initials: Y
authors.lastname: Amano
authors.forename: Masaki
authors.initials: M
authors.lastname: Tachi
authors.forename: Tadashi
authors.initials: T
authors.lastname: Machida
authors.forename: Kyoichi
authors.initials: K
authors.lastname: Mizuno
authors.forename: Shinichiro
authors.initials: S
authors.lastname: Kumita
mesh_terms: D000328:Adult; D000368:Aged; D003287:Contrast Media; D003937:Diagnosis, Differential; D004804:Eosinophils; D005260:Female; D006801:Humans; D017681:Hypereosinophilic Syndrome / Q000175:diagnosis* / Q000503:physiopathology*; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D008875:Middle Aged; D009205:Myocarditis / Q000175:diagnosis* / Q000503:physiopathology*; D011237:Predictive Value of Tests; D012189:Retrospective Studies; D012680:Sensitivity and Specificity; D013318:Stroke Volume; D016277:Ventricular Function, Left
chemical_list: D003287:Contrast Media