title: Protein evolution: when two become three.
abstract: Bacterial signaling pathways provide wonderful systems for analyzing protein evolution in vivo. A systematic dissection of the phosphate-sensing machinery in proteobacteria shows that adaptive, not neutral, mutations disable deleterious crosstalk with closely related signaling systems.
authors.affiliation: Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02130, USA.
authors.forename: Pierre
authors.initials: P
authors.lastname: Stallforth
authors.forename: Jon
authors.initials: J
authors.lastname: Clardy
mesh_terms: D020561:Alphaproteobacteria / Q000235:genetics* / Q000378:metabolism*; D001426:Bacterial Proteins / Q000235:genetics*; D019143:Evolution, Molecular; D009154:Mutation; D010802:Phylogeny; D012641:Selection, Genetic; D015398:Signal Transduction
chemical_list: D001426:Bacterial Proteins; C061279:PhoR protein, Bacteria