title: Terpene and lignan glycosides from the twigs and leaves of an endangered conifer, Cathaya argyrophylla.
abstract: Labdane diterpene glycosides cathargyroside A and cathargyroside B, monoterpene glycosides vervenone-10-O-β-D-glucopyranoside and vervenone-10-O-β-D-apiofuranosyl-(1″→6')-β-D-glucopyranoside, as well as lignan glycosides cedrusinin-4-O-α-L-rhamnopyranoside and (+)-cyclo-olivil-9'-O-β-D-xylopyranoside, along with 39 known compounds, were obtained from the methanol extract of the twigs and leaves of Cathaya argyrophylla. These compounds were identified mainly by analyzing their NMR and MS data. Almost all of these compounds were hitherto unknown in this genus. The isolated compounds were screened against Candida albicans and Staphylococcus aureus for antimicrobial assay, and against K562, HT-29, BEL-7402, SGC-7901, B16, BGC-823, U251 and A549 cancer cell lines for cytotoxic activities. One compound showed antimicrobial activity against C. albicans, and four of them displayed cytotoxicity. Similarity analysis on the chemical constituents of the genera Cathaya, Picea and Pinus supported their close phylogenetic relationships.
authors.affiliation: State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, Yunnan, PR China.
authors.forename: Wen-Jun
authors.initials: WJ
authors.lastname: He
authors.forename: Zhao-Hui
authors.initials: ZH
authors.lastname: Fu
authors.forename: Guang-Zhi
authors.initials: GZ
authors.lastname: Zeng
authors.forename: Yu-Mei
authors.initials: YM
authors.lastname: Zhang
authors.forename: Hong-Jin
authors.initials: HJ
authors.lastname: Han
authors.forename: He
authors.initials: H
authors.lastname: Yan
authors.forename: Chang-Jiu
authors.initials: CJ
authors.lastname: Ji
authors.forename: Hong-Biao
authors.initials: HB
authors.lastname: Chu
authors.forename: Ning-Hua
authors.initials: NH
authors.lastname: Tan
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D002176:Candida albicans / Q000187:drug effects*; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D004354:Drug Screening Assays, Antitumor; D006027:Glycosides / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D006801:Humans; D017705:Lignans / Q000737:chemistry; D008826:Microbial Sensitivity Tests; D008968:Molecular Conformation; D028201:Pinaceae / Q000737:chemistry*; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D018515:Plant Leaves / Q000737:chemistry; D018547:Plant Stems / Q000737:chemistry; D013211:Staphylococcus aureus / Q000187:drug effects*; D013329:Structure-Activity Relationship; D013729:Terpenes / Q000737:chemistry
chemical_list: D000900:Anti-Bacterial Agents; D000972:Antineoplastic Agents, Phytogenic; D006027:Glycosides; D017705:Lignans; D010936:Plant Extracts; D013729:Terpenes