title: Guidelines change the diagnostic process of cow milk food allergy:  problem-based learning.
abstract: OBJECTIVE
  The accurate diagnosis of food allergy and its management has been the subject of two published guidelines, the National Institute of Health Sponsored Expert Panel Guidelines and the World Allergy Organization guidelines: Diagnosis and Rationale for Action Against Cow Milk Allergy. Both guidelines have drawn attention to the unique aspects of different food allergens. They have highlighted the possible overdiagnosis and underdiagnosis of food allergy. The purpose of this review is to demonstrate the utility and application of the two published guidelines in a real-life scenario that the pediatrician or allergy/immunology specialist may be faced with.
  
  
  RESULTS
  This review is divided into two sections: the first section is problem-based learning, presenting a clinical scenario of a child suspected of cow milk allergy (CMA) and followed over time. At each step, the guidelines are consulted and referenced. The second section reviews recent research that demonstrates that CMA has a high prevalence, and that testing methodologies can be improved on.
  
  
  CONCLUSIONS
  Clinicians taking the approach outlined by the guidelines will be able to confirm or refute a diagnosis of CMA, all the while minimizing unnecessary tests and procedures.
authors.affiliation: Division of Allergy and Immunology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA. amal.assa'ad@cchmc.org
authors.forename: Amal
authors.initials: A
authors.lastname: Assa'ad
authors.forename: Alessandro
authors.initials: A
authors.lastname: Fiocchi
mesh_terms: D000485:Allergens / Q000276:immunology; D000818:Animals; D002675:Child, Preschool; D006801:Humans; D007073:Immunoglobulin E / Q000097:blood; D008297:Male; D008892:Milk / Q000276:immunology; D016269:Milk Hypersensitivity / Q000175:diagnosis* / Q000453:epidemiology / Q000209:etiology; D017410:Practice Guidelines as Topic / Q000592:standards*; D015995:Prevalence; D018794:Problem-Based Learning / Q000379:methods*; D012882:Skin Tests
chemical_list: D000485:Allergens; D007073:Immunoglobulin E