title: Antibiotic susceptibility in prostate-derived Propionibacterium acnes isolates.
abstract: The aim of this study was to determine antibiotic susceptibility of Propionibacterium acnes isolates from prostate. Prostate-derived P. acnes isolates (n = 24, Umeå & Örebro, Sweden, 2007-2010) and a panel of control strains (n = 25, Sweden) collected from skin and deep infections were assessed for resistance to penicillin G, piperacillin-tazobactam, imipenem, gentamicin, azithromycin, erythromycin, vancomycin, ciprofloxacin, moxifloxacin, tetracycline, tigecycline, fusidic acid, clindamycin, rifampicin, linezolid, daptomycin, trimethoprim-sulfamethoxazole, and metronidazole. In addition, the isolates were tested for inducible clindamycin resistance. All prostate derived P. acnes isolates displayed wild-type distribution of MIC-values, without evidence of acquired resistance. In the reference panel, 5 of 25 isolates had acquired macrolide resistance with cross-resistance to azithromycin, clindamycin, and erythromycin. In addition, one of these isolates was resistant to tetracycline.
authors.affiliation: Department of Clinical Microbiology, Umeå University, Sweden. jan.olsson@climi.umu.se
authors.forename: Jan
authors.initials: J
authors.lastname: Olsson
authors.forename: Sabina
authors.initials: S
authors.lastname: Davidsson
authors.forename: Magnus
authors.initials: M
authors.lastname: Unemo
authors.forename: Paula
authors.initials: P
authors.lastname: Mölling
authors.forename: Swen-Olov
authors.initials: SO
authors.lastname: Andersson
authors.forename: Ove
authors.initials: O
authors.lastname: Andrén
authors.forename: Bo
authors.initials: B
authors.lastname: Söderquist
authors.forename: Mats
authors.initials: M
authors.lastname: Sellin
authors.forename: Fredrik
authors.initials: F
authors.lastname: Elgh
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001707:Biopsy, Needle; D003470:Culture Media; D024901:Drug Resistance, Multiple, Bacterial; D006801:Humans; D008297:Male; D008826:Microbial Sensitivity Tests; D011425:Propionibacterium acnes / Q000187:drug effects* / Q000235:genetics / Q000302:isolation & purification; D011467:Prostate / Q000382:microbiology* / Q000601:surgery; D011471:Prostatic Neoplasms / Q000382:microbiology* / Q000601:surgery; D012867:Skin / Q000382:microbiology; D013548:Sweden
chemical_list: D000900:Anti-Bacterial Agents; D003470:Culture Media