title: Change in plasma visfatin level after severe traumatic brain injury.
abstract: Higher plasma visfatin concentration has been associated with ischemic stroke. Thus, we sought to investigate change in plasma visfatin level after traumatic brain injury and to evaluate its relation with disease outcome. Seventy-six healthy controls and 98 patients with acute severe traumatic brain injury were recruited. Twenty-seven patients (27.6%) died and 48 patients (49.0%) suffered from unfavorable outcome (Glasgow outcome scale score of 1-3) in 6 months. On admission, plasma visfatin level was increased in patients than in healthy controls and was highly correlated with Glasgow Coma Scale score. A multivariate analysis identified plasma visfatin level as an independent predictor for 6-month mortality and unfavorable outcome. According to receiver operating characteristic curve analysis, the predictive value of the plasma visfatin concentration was similar to Glasgow Coma Scale score's. In a combined logistic-regression model, visfatin did not improve the predictive value of Glasgow Coma Scale score. Thus, increased plasma visfatin level is associated with 6-month clinical outcomes after severe traumatic brain injury.
authors.affiliation: Department of Neurosurgery, the Second People's Hospital of Cixi City, Cixi 315315, China.
authors.forename: Jun
authors.initials: J
authors.lastname: Chen
authors.forename: Jian-Feng
authors.initials: JF
authors.lastname: Weng
authors.forename: Wei-Cong
authors.initials: WC
authors.lastname: Hong
authors.forename: Li-Feng
authors.initials: LF
authors.lastname: Luo
authors.forename: Wei
authors.initials: W
authors.lastname: Yu
authors.forename: Shi-Da
authors.initials: SD
authors.lastname: Luo
mesh_terms: D000328:Adult; D001930:Brain Injuries / Q000097:blood* / Q000401:mortality*; D016022:Case-Control Studies; D016207:Cytokines / Q000097:blood*; D005260:Female; D023261:Glasgow Outcome Scale; D006801:Humans; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D054409:Nicotinamide Phosphoribosyltransferase / Q000097:blood*; D011237:Predictive Value of Tests; D011379:Prognosis; D012372:ROC Curve
chemical_list: D016207:Cytokines; D054409:Nicotinamide Phosphoribosyltransferase; C085455:nicotinamide phosphoribosyltransferase, human