title: Lymph and blood cytokines in fever of different severity.
abstract: Experiments on rats showed that pyrogenal-induced fever is associated with elevation of IL-1β, IL-6, and IL-10 content in the thoracic duct lymph and blood plasma, whereas low-grade fever induced by administration of Freund's complete adjuvant is associated with elevation of only IL-6 concentration. The increase in IL-1β concentration during fever and IL-6 concentration in both processes was more pronounced in the central lymph than in blood plasma. Unchanged concentrations of IL-1β and IL-10 in low-grade fever apparently reflect differences in the mechanisms of these pathological processes.
authors.affiliation: Department of Pathophysiology, Kazan State Medical University, Russia. fimka54@mail.ru
authors.forename: F I
authors.initials: FI
authors.lastname: Mukhutdinova
authors.forename: I G
authors.initials: IG
authors.lastname: Mustafin
authors.forename: R Kh
authors.initials: RKh
authors.lastname: Khafiz'yanova
mesh_terms: D000818:Animals; D016207:Cytokines / Q000097:blood*; D004797:Enzyme-Linked Immunosorbent Assay; D005334:Fever / Q000097:blood* / Q000139:chemically induced; D005620:Freund's Adjuvant / Q000008:administration & dosage / Q000633:toxicity; D016753:Interleukin-10 / Q000097:blood; D053583:Interleukin-1beta / Q000097:blood; D015850:Interleukin-6 / Q000097:blood; D008070:Lipopolysaccharides / Q000008:administration & dosage / Q000633:toxicity; D008196:Lymph / Q000378:metabolism*; D051381:Rats; D013897:Thoracic Duct / Q000378:metabolism*
chemical_list: D016207:Cytokines; D053583:Interleukin-1beta; D015850:Interleukin-6; D008070:Lipopolysaccharides; C009136:pyrogenal; D016753:Interleukin-10; D005620:Freund's Adjuvant