title: Carboplatin plus paclitaxel in the successful treatment of advanced inflammatory myofibroblastic tumor.
abstract: A 26-year-old man with unresectable inflammatory myofibroblastic tumor (IMT) presented with multiple metastases in the thoracic vertebra and lymph nodes as detected by positron emission tomography (PET) received chemotherapy with carboplatin plus paclitaxel. After three cycles of chemotherapy, fluorine-18-fluorodeoxyglucose (FDG)-PET/CT revealed tumor regression and significant reduction of FDG uptake in all lesions. The patient received six cycles of chemotherapy without any severe adverse event, and there was no sign of disease progression for seven months. This regimen is well tolerated and may be considered the treatment of choice for unresectable IMT.
authors.affiliation: Research Institute for Disease of the Chest, Graduate School of Medical Sciences, Kyushu University, Japan.
authors.forename: Naoki
authors.initials: N
authors.lastname: Kubo
authors.forename: Taishi
authors.initials: T
authors.lastname: Harada
authors.forename: Satoshi
authors.initials: S
authors.lastname: Anai
authors.forename: Kohei
authors.initials: K
authors.lastname: Otsubo
authors.forename: Yasuto
authors.initials: Y
authors.lastname: Yoneshima
authors.forename: Kayo
authors.initials: K
authors.lastname: Ijichi
authors.forename: Takaomi
authors.initials: T
authors.lastname: Koga
authors.forename: Koichi
authors.initials: K
authors.lastname: Takayama
authors.forename: Yoichi
authors.initials: Y
authors.lastname: Nakanishi
mesh_terms: D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D001859:Bone Neoplasms / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000556:secondary; D016190:Carboplatin / Q000627:therapeutic use*; D019788:Fluorodeoxyglucose F18; D006801:Humans; D008207:Lymphatic Metastasis / Q000000981:diagnostic imaging; D008297:Male; D008479:Mediastinal Neoplasms / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000473:pathology; D009367:Neoplasm Staging; D009379:Neoplasms, Muscle Tissue / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000556:secondary; D017239:Paclitaxel / Q000627:therapeutic use*; D049268:Positron-Emission Tomography; D011859:Radiography; D013904:Thoracic Vertebrae / Q000000981:diagnostic imaging; D016896:Treatment Outcome
chemical_list: D019788:Fluorodeoxyglucose F18; D016190:Carboplatin; D017239:Paclitaxel