title: Bacteria-responsive multifunctional nanogel for targeted antibiotic delivery.
abstract: Bacteria-Responsive Multifunctional Nanogel: We developed a bacteria-responsive multifunctional nanogel for targeted antibiotic delivery, in which bacterial enzymes are utilized to trigger antibiotic release by degrading the polyphosphoester core. The mannosylated nanogel preferentially delivers drugs to macrophages and leads to drug accumulation at bacterial infection sites through macrophage transport. This nanogel provides macrophage targeting and lesion site-activatable drug release properties, which enhances bacterial growth inhibition.
authors.affiliation: CAS Key Laboratory of Soft Matter Chemistry and Department of Polymer Science and Engineering, University of Science and Technology of China, Hefei, Anhui 230026, P. R. China.
authors.forename: Meng-Hua
authors.initials: MH
authors.lastname: Xiong
authors.forename: Ya-Juan
authors.initials: YJ
authors.lastname: Li
authors.forename: Yan
authors.initials: Y
authors.lastname: Bao
authors.forename: Xian-Zhu
authors.initials: XZ
authors.lastname: Yang
authors.forename: Bing
authors.initials: B
authors.lastname: Hu
authors.forename: Jun
authors.initials: J
authors.lastname: Wang
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects* / Q000201:enzymology; D002460:Cell Line; D004337:Drug Carriers / Q000737:chemistry*; D004625:Embryo, Nonmammalian / Q000378:metabolism; D008264:Macrophages / Q000378:metabolism; D055624:Methicillin-Resistant Staphylococcus aureus / Q000187:drug effects; D051379:Mice; D018613:Microscopy, Confocal; D000080385:Nanogels; D010587:Phagocytosis / Q000187:drug effects; D010740:Phospholipases / Q000378:metabolism; D011092:Polyethylene Glycols / Q000737:chemistry*; D011094:Polyethyleneimine / Q000737:chemistry*; D014640:Vancomycin / Q000737:chemistry / Q000494:pharmacology; D015027:Zebrafish / Q000254:growth & development
chemical_list: D000900:Anti-Bacterial Agents; D004337:Drug Carriers; D000080385:Nanogels; C413692:polyethylene glycol polyethyleneimine nanogel; D011092:Polyethylene Glycols; D014640:Vancomycin; D011094:Polyethyleneimine; D010740:Phospholipases