title: What is the future of (ultra) high performance liquid chromatography coupled to low and high resolution mass spectrometry for toxicological drug screening?
abstract: This paper reviews critically LC-MS approaches for toxicological drug screening using (ultra) high performance liquid chromatography (UHPLC) coupled to low and high resolution mass spectrometry (HRMS) published since 2010. A concluding discussion focuses on progress and current status of sample workup, separation by HPLC vs. UHPLC, MS detection modes and their specificity, universality of LC-MS libraries, and validation necessary of LC-MS for screening methods. Finally, a discussion on what the future holds for LC-MS drug screening in clinical and forensic toxicology completes this review article.
authors.affiliation: Department of Experimental and Clinical Toxicology, Institute of Experimental and Clinical Pharmacology and Toxicology, Saarland University, D-66421 Homburg (Saar), Germany. hans.maurer@uks.eu
authors.forename: Hans H
authors.initials: HH
authors.lastname: Maurer
mesh_terms: D000818:Animals; D002853:Chromatography, Liquid / Q000295:instrumentation / Q000379:methods*; D062313:Databases, Pharmaceutical; D004353:Drug Evaluation, Preclinical / Q000295:instrumentation / Q000379:methods*; D053593:Forensic Toxicology / Q000295:instrumentation / Q000379:methods; D006801:Humans; D013058:Mass Spectrometry / Q000295:instrumentation / Q000379:methods*; D018675:Toxicity Tests / Q000295:instrumentation / Q000379:methods