title: Serine-type carboxypeptidase KexA of Aspergillus oryzae has broader substrate specificity than Saccharomyces cerevisiae Kex1 and is required for normal hyphal growth and conidiation.
abstract: Aspergillus oryzae has an ortholog of Saccharomyces cerevisiae KEX1, termed kexA. A truncated form of KexA protein showed serine-type carboxypeptidase activity and somewhat broader substrate specificity than Kex1 protease. Furthermore, our results indicated that KexA is required for normal growth of A. oryzae and that it might be involved in hyphal branching.
authors.affiliation: Department of Applied Molecular Biology and Biochemistry, Tokyo University of Agriculture and Technology, Fuchu, Tokyo, Japan.
authors.forename: Hiroto
authors.initials: H
authors.lastname: Morita
authors.forename: Sayako
authors.initials: S
authors.lastname: Tomita
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Maeda
authors.forename: Ayako
authors.initials: A
authors.lastname: Okamoto
authors.forename: Youhei
authors.initials: Y
authors.lastname: Yamagata
authors.forename: Ken-Ichi
authors.initials: K
authors.lastname: Kusumoto
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Amano
authors.forename: Hiroki
authors.initials: H
authors.lastname: Ishida
authors.forename: Michio
authors.initials: M
authors.lastname: Takeuchi
mesh_terms: D001236:Aspergillus oryzae / Q000201:enzymology* / Q000254:growth & development; D002268:Carboxypeptidases / Q000737:chemistry / Q000378:metabolism*; D025301:Hyphae / Q000201:enzymology* / Q000254:growth & development; D012441:Saccharomyces cerevisiae / Q000201:enzymology; D013379:Substrate Specificity; D037521:Virulence Factors / Q000737:chemistry / Q000378:metabolism*
chemical_list: D037521:Virulence Factors; D002268:Carboxypeptidases; C022633:serine carboxypeptidase