title: Polyketide metabolites from the endophytic fungus Microdiplodia sp. KS 75-1.
abstract: Through our screening for new natural compounds, four new polyketide metabolites, 7,8-dihydonivefuranone A (1), 6(7)-dehydro-8-hydroxyterrefuranone (2), 8-hydroxyterrefuranone (3), and 6-hydroxyterrefuranone (4) were isolated from the fermentation extract of Microdiplodia sp. KS 75-1, together with the known compounds nivefuranones A (5) and B (6); their structures were determined by spectroscopic (NMR, UV and IR) and MS analysis. Compounds 1, 2, 4 and 5 showed antimicrobial activity against Candida albicans and Staphylococcus aureus.
authors.affiliation: Department ofFood, Life, and Environmental Science, Faculty ofAgriculture Yamagata University, Tsuruoka, Yamagata 997-8555, Japan. yshiono@tdsl.tr.yamagata-u.ac.jp
authors.forename: Yoshihito
authors.initials: Y
authors.lastname: Shiono
authors.forename: Taiji
authors.initials: T
authors.lastname: Hatakeyama
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Murayama
authors.forename: Takuya
authors.initials: T
authors.lastname: Koseki
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000494:pharmacology*; D001203:Ascomycota / Q000737:chemistry* / Q000378:metabolism*; D015394:Molecular Structure; D061065:Polyketides / Q000737:chemistry* / Q000378:metabolism*
chemical_list: D000900:Anti-Bacterial Agents; D061065:Polyketides