title: Platelet distribution width and saphenous vein disease in patients after CABG. Association with graft occlusion.
abstract: OBJECTIVE
  Platelets are involved in the pathogenesis of atherosclerosis. The inflammatory process in atherosclerosis may cause an increase in red blood cell distribution width (RDW) and platelet distribution width (PDW) values. Therefore, in this study we aimed to investigate whether PDW and RDW are associated with the patency of saphenous vein graft in patients at least 1 year after coronary artery bypass graft (CABG) surgery.
  
  
  METHODS
  Patients who had undergone CABG surgery at least 1 year previously with at least one saphenous vein graft were included in the study population. Patients were referred to cardiac catheterization for stable anginal symptoms or positive stress test results. Before coronary angiography, all patients referred had routine blood tests including RDW and PDW values.
  
  
  RESULTS
  Saphenous vein grafts were found to be patent in 69 patients and occluded in 40 patients. Although RDW levels were similar between patients with patent and occluded grafts (13.1 ± 1.1% and 13.2 ± 0.7% respectively, p = 0.37), PDW levels were significantly different between the two groups (13.1 ± 1.3% and 14.1 ± 1.1 respectively, p = 0.03). Although time after CABG operation differs significantly between the two groups (p < 0.001), multiple logistic regression analyses showed that PDW levels were found to be significantly associated with the patency of vein graft (β = 1.682, 95% CI 1.117-2.532, p = 0.013).
  
  
  CONCLUSIONS
  Our results showed that PDW levels were higher in patients with an occluded saphenous vein graft. However no association was found between the saphenous vein graft disease and RDW values. To verify this relationship between PDW values and saphenous vein graft patency, further investigations are needed.
authors.affiliation: Clinic of Cardiology, Kavaklidere Umut Hospital, Buklum sokak, no 72, Ankara, Turkey. drmeltemege@yahoo.com.tr
authors.forename: M R
authors.initials: MR
authors.lastname: Ege
authors.forename: U
authors.initials: U
authors.lastname: Guray
authors.forename: Y
authors.initials: Y
authors.lastname: Guray
authors.forename: S
authors.initials: S
authors.lastname: Acıkgoz
authors.forename: B
authors.initials: B
authors.lastname: Demirkan
mesh_terms: D001792:Blood Platelets / Q000473:pathology*; D015984:Causality; D015897:Comorbidity; D001026:Coronary Artery Bypass / Q000706:statistics & numerical data*; D023921:Coronary Stenosis / Q000453:epidemiology / Q000473:pathology / Q000601:surgery*; D005260:Female; D006083:Graft Occlusion, Vascular / Q000453:epidemiology / Q000473:pathology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D018570:Risk Assessment; D012501:Saphenous Vein / Q000473:pathology / Q000637:transplantation*; D014421:Turkey / Q000453:epidemiology; D014689:Venous Insufficiency / Q000453:epidemiology / Q000473:pathology*