title: The role of inflammatory cells in fostering pancreatic cancer cell growth and invasion.
abstract: The pancreatic ductal adenocarcinoma (PDAC) microenvironment accommodates a variety of cell types and a plethora of complex interactions between tumor cells, host cells and extracellular matrix (ECM) components. Here we review the role of inflammatory cells, in particular mast cells, myeloid-derived suppressor cells, macrophages, T regulatory cells, T helper cells and neutrophils. The picture that emerges is that of a tumor microenvironment, in which the immune response is actively suppressed, and inflammatory cells contribute in a variety of ways to tumor progression.
authors.affiliation: Liverpool Cancer Research UK Centre, University of Liverpool Liverpool, UK.
authors.forename: Anthony
authors.initials: A
authors.lastname: Evans
authors.forename: Eithne
authors.initials: E
authors.lastname: Costello