title: [Intrasellar gangliocytoma associated with growth hormone-producing pituitary adenoma. Case report].
abstract: BACKGROUND
  Intrasellar gangliocytomas are uncommon entities which, unusually, may be found in association with hormone-releasing pituitary adenomas.
  
  
  METHODS
  The patient was a 49-year-old female who presented a sellar lesion with associated acromegaly. A trans-sphenoidal tumour was removed, with no medical improvement. Histopathological analysis revealed a gangliocytoma with an associated somatotroph adenoma.
  
  
  CONCLUSIONS
  We found 85 cases of intrasellar gangliocytomas with associated hormone-releasing pituitary adenomas reported in the literature, with the following distribution: 50 growth hormone-releasing (GH) cases (59%), 15 mixed (GH and prolactin-releasing) cases (17%), 11 prolactin-releasing cases (13%), 7 adrenocorticotropic hormone-releasing (ACTH) cases (8%) and 2 corticotropin hormone-releasing (CRH) cases (2%).
  
  
  CONCLUSIONS
  Mixed gangliocytomas-adenomas are uncommon entities. Association with growth hormone-releasing cases is more frequent and the most common presentation is among middle-aged females. Diagnosis is histopathological. Identification of this entity is important because it may lead to a limitation in therapeutic response in incomplete resections.
authors.affiliation: Servicio de Neurocirugía, Hospital Regional Universitario Carlos Haya, Málaga, España. Electronic address: lorenaromeromoreno@gmail.com.
authors.forename: Lorena
authors.initials: L
authors.lastname: Romero
authors.forename: Andrea
authors.initials: A
authors.lastname: Arcos
authors.forename: María Dolores
authors.initials: MD
authors.lastname: Bautista
authors.forename: Miguel
authors.initials: M
authors.lastname: Domínguez
authors.forename: Juan M
authors.initials: JM
authors.lastname: Medina
authors.forename: Miguel A
authors.initials: MA
authors.lastname: Arráez
mesh_terms: D000172:Acromegaly; D000236:Adenoma; D005729:Ganglioneuroma; D013006:Growth Hormone; D006801:Humans; D010911:Pituitary Neoplasms / Q000601:surgery
chemical_list: D013006:Growth Hormone