title: A new flavanocoumarin from the root of Flemingia philippinensis.
abstract: One new flavanocoumarin, flemicoumarin A (1) was isolated from the EtOAc-soluble partition of the root of Flemingia philippinensis, along with three known compounds, namely 4,2'-epoxy-4',5-dihydroxy-7,5'-dimethoxy-3-phenylcoumarin (2), kaempferol 6-C-glucoside (3) and dracocephaloside (4). The structure of compound 1 was elucidated on the basis of its 1D, 2D NMR, CD and MS data. The structures of the known compounds were identified by comparison of their spectroscopic data with those reported in the literature. Compounds 1-4 exhibited inactivity against MCF-7, A549 and Hep-G2 human cancer cell lines in vitro by MTT colorimetric assay.
authors.affiliation: Guangdong Open Access Laboratory of Agricultural Product Processing, Sericulture and Farm Produce Processing Research Institute, Guangdong Academy of Agricultural Sciences, Guangzhou 510610, PR China.
authors.forename: Manqin
authors.initials: M
authors.lastname: Fu
authors.forename: Dun
authors.initials: D
authors.lastname: Deng
authors.forename: Riming
authors.initials: R
authors.lastname: Huang
authors.forename: Nenling
authors.initials: N
authors.lastname: Zhang
authors.forename: Zhiwei
authors.initials: Z
authors.lastname: Su
authors.forename: Samuel X
authors.initials: SX
authors.lastname: Qiu
mesh_terms: D002942:Circular Dichroism; D003374:Coumarins / Q000737:chemistry / Q000302:isolation & purification*; D000431:Ethanol; D007887:Fabaceae / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D015394:Molecular Structure; D010936:Plant Extracts / Q000737:chemistry*; D018517:Plant Roots / Q000737:chemistry*
chemical_list: D003374:Coumarins; D010936:Plant Extracts; D000431:Ethanol