title: Prosthetic limb salvage surgery for bone and soft tissue tumors around             the knee.
abstract: In this study, we analyzed long-term survival, limb function and associated             complications after prosthetic limb salvage treatment in patients with bone and             soft tissue tumors around the knee joint. A total of 63 patients treated with             prosthetic limb salvage surgery around the knee were reviewed. The bone tumors             involved the distal femur in 45 patients, the proximal tibia in 14 patients and             the soft tissue tumors of the proximal lower leg in 4 patients. The median follow-up             period after the first operation was 8.0 years. The medical records of the patients,             surgical reports, radiographs and histological specimens were retrospectively             reviewed. The 5-year overall survival rate was 63.2% in the patients with distal             femur tumors and 86.2% in those with tumors of the proximal lower leg. The 5‑year             prosthetic survival rate was 72.8% in the distal femur and 74.6% in the proximal             lower leg. The mean functional score according to the scoring system of the Musculoskeletal             Tumor Society (MSTS) was 81% in the patients with distal femur tumors and 82%             in the patients with proximal lower leg tumors. Post-operative complications occurred             in 27 patients. Limb salvage surgery is considered to be an effective treatment             option. However, the high complication rate is a major concern for prosthetic             replacement. Future improvements of prostheses are very important.
authors.affiliation: Department of Orthopaedic Surgery, Mie University Graduate School of Medicine, Mie 514-8507, Japan.
authors.forename: Rui
authors.initials: R
authors.lastname: Niimi
authors.forename: Akihiko
authors.initials: A
authors.lastname: Matsumine
authors.forename: Takahiko
authors.initials: T
authors.lastname: Hamaguchi
authors.forename: Tomoki
authors.initials: T
authors.lastname: Nakamura
authors.forename: Atsumasa
authors.initials: A
authors.lastname: Uchida
authors.forename: Akihiro
authors.initials: A
authors.lastname: Sudo
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001186:Artificial Limbs; D001859:Bone Neoplasms / Q000401:mortality / Q000601:surgery*; D002648:Child; D002813:Chondrosarcoma / Q000401:mortality / Q000601:surgery; D005260:Female; D005269:Femur / Q000473:pathology / Q000601:surgery; D005870:Giant Cell Tumors / Q000401:mortality / Q000601:surgery; D051677:Histiocytoma, Malignant Fibrous / Q000401:mortality / Q000601:surgery; D006801:Humans; D007717:Knee / Q000473:pathology / Q000601:surgery; D007719:Knee Joint / Q000473:pathology / Q000601:surgery; D007720:Knee Prosthesis; D007866:Leg / Q000473:pathology / Q000601:surgery; D023821:Limb Salvage; D008297:Male; D008875:Middle Aged; D012516:Osteosarcoma / Q000401:mortality / Q000601:surgery; D012189:Retrospective Studies; D012983:Soft Tissue Neoplasms / Q000401:mortality / Q000601:surgery*; D015996:Survival Rate; D013977:Tibia / Q000473:pathology / Q000601:surgery; D016896:Treatment Outcome; D055815:Young Adult