title: On the noninvasive optical monitoring and differentiation of methemoglobinemia and sulfhemoglobinemia.
abstract: There are several pathologies whose study and diagnosis is impaired by a relatively small number of documented cases. A practical approach to overcome this obstacle and advance the research in this area consists in employing computer simulations to perform controlled in silico experiments. The results of these experiments, in turn, may be incorporated in the design of differential protocols for these pathologies. Accordingly, in this paper, we investigate the spectral responses of human skin affected by the presence of abnormal amounts of two dysfunctional hemoglobins, methemoglobin and sulfhemoglobin, which are associated with two life-threatening medical conditions, methemoglobinemia and sulfhemoglobinemia, respectively. We analyze the results of our in silico experiments and discuss their potential applications to the development of more effective noninvasive monitoring and differentiation procedures for these medical conditions.
authors.affiliation: University of Waterloo, Natural Phenomena Simulation Group, School of Computer Science, 200 University Avenue West, Waterloo, Ontario, Canada N2L 3G1. gvgbaran@curumin.math.uwaterloo.ca
authors.forename: Gladimir V G
authors.initials: GV
authors.lastname: Baranoski
authors.forename: Tenn F
authors.initials: TF
authors.lastname: Chen
authors.forename: Bradley W
authors.initials: BW
authors.lastname: Kimmel
authors.forename: Erik
authors.initials: E
authors.lastname: Miranda
authors.forename: Daniel
authors.initials: D
authors.lastname: Yim
mesh_terms: D003936:Diagnosis, Computer-Assisted / Q000379:methods; D003937:Diagnosis, Differential; D006454:Hemoglobins / Q000032:analysis*; D008708:Methemoglobinemia / Q000175:diagnosis* / Q000378:metabolism*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D012867:Skin / Q000378:metabolism*; D013057:Spectrum Analysis / Q000379:methods*; D013436:Sulfhemoglobinemia / Q000175:diagnosis* / Q000378:metabolism*
chemical_list: D006454:Hemoglobins