title: Significance of stromal decorin expression during the progression of             breast cancer.
abstract: Decorin, a small leucine-rich proteoglycan and important component of the             extracellular matrix (ECM), is a natural anticancer agent that modulates several             receptors involved in cell growth and survival. Reductions in decorin expression             may weaken the ECM and enhance the effectiveness of these receptors and may, consequently,             lead to tumor spreading. To determine the contribution of stromal decorin regulation             in the development of breast cancer and in tumor invasiveness, immunohistochemistry             was used to examine the expression of stromal decorin in 120 breast cancer tissue             samples. In patients with invasive breast carcinoma (IBC), stromal decorin expression             was highest in normal gland tissue, lower in in situ components and the lowest             in invasive components. Stromal decorin expression adjacent to malignant cells             in IBC tumors was also significantly weaker compared to that in pure ductal carcinoma             in situ (DCIS). These findings indicate that there is a striking difference in             the stromal decorin expression around normal glands and around DCIS or IBC tumors.             Reduced levels of decorin were associated with more aggressive disease; this finding             was consistent with the view that reduced decorin expression may facilitate tumorigenesis,             tumor invasion and/or tumor growth. Given these and other reported findings, evaluating             stromal decorin expression may be useful in assessing prognosis and malignant             potential; therefore, a large-scale study of decorin expression is warranted.
authors.affiliation: Department of Surgical Oncology, Tokyo Medical and Dental University, Graduate School of Medicine and Dentistry, Bunkyo-ku, Tokyo 113-8519, Japan.
authors.forename: Goshi
authors.initials: G
authors.lastname: Oda
authors.forename: Takanobu
authors.initials: T
authors.lastname: Sato
authors.forename: Toshiaki
authors.initials: T
authors.lastname: Ishikawa
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Kawachi
authors.forename: Tsuyoshi
authors.initials: T
authors.lastname: Nakagawa
authors.forename: Takashi
authors.initials: T
authors.lastname: Kuwayama
authors.forename: Megumi
authors.initials: M
authors.lastname: Ishiguro
authors.forename: Satoru
authors.initials: S
authors.lastname: Iida
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Uetake
authors.forename: Kenichi
authors.initials: K
authors.lastname: Sugihara
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000378:metabolism; D001943:Breast Neoplasms / Q000378:metabolism* / Q000473:pathology; D002285:Carcinoma, Intraductal, Noninfiltrating / Q000378:metabolism*; D058575:Decorin / Q000096:biosynthesis*; D018450:Disease Progression; D005109:Extracellular Matrix / Q000378:metabolism*; D016326:Extracellular Matrix Proteins / Q000378:metabolism; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D017154:Stromal Cells / Q000378:metabolism*
chemical_list: D014408:Biomarkers, Tumor; C546878:DCN protein, human; D058575:Decorin; D016326:Extracellular Matrix Proteins