title: Inferring evoked brain connectivity through adaptive perturbation.
abstract: Inference of functional networks-representing the statistical associations between time series recorded from multiple sensors-has found important applications in neuroscience. However, networksexhibiting time-locked activity between physically independent elements can bias functional connectivity estimates employing passive measurements. Here, a perturbative and adaptive method of inferring network connectivity based on measurement and stimulation-so called "evoked network connectivity" is introduced. This procedure, employing a recursive Bayesian update scheme, allows principled network stimulation given a current network estimate inferred from all previous stimulations and recordings. The method decouples stimulus and detector design from network inference and can be suitably applied to a wide range of clinical and basic neuroscience related problems. The proposed method demonstrates improved accuracy compared to network inference based on passive observation of node dynamics and an increased rate of convergence relative to network estimation employing a naïve stimulation strategy.
authors.affiliation: Department of Mathematics & Statistics, Boston University, Boston, MA 02215, USA. lepage@math.bu.edu
authors.forename: Kyle Q
authors.initials: KQ
authors.lastname: Lepage
authors.forename: ShiNung
authors.initials: S
authors.lastname: Ching
authors.forename: Mark A
authors.initials: MA
authors.lastname: Kramer
mesh_terms: D000818:Animals; D001499:Bayes Theorem; D001683:Biological Clocks / Q000502:physiology*; D001703:Biophysics; D001921:Brain / Q000502:physiology*; D003198:Computer Simulation; D006801:Humans; D008959:Models, Neurological; D016571:Neural Networks, Computer