title: Utility of cefixime as a complexing reagent for the determination of Ni(II) in synthetic mixture and water samples.
abstract: A simple, sensitive, and accurate UV spectrophotometric method has been developed for the determination of nickel in synthetic mixture and water samples. The method is based on the complexation reaction of nickel ion with cefixime, thus leading to the formation of Ni-cefixime complex in ethanol-distilled water medium at room temperature. The complex showed the maximum absorption wavelength at 332 nm. Beer's law is obeyed in the working concentration range of 0.447-4.019 μg mL(-1) with apparent molar absorptivity of 7.314 × 10(3) L mol(-1) cm(-1) and Sandell's sensitivity of 0.008 μg/cm(2)/0.001 absorbance unit. The limits of detection and quantitation for the proposed method are 0.016 and 0.054 μg mL(-1), respectively. The factors such as cefixime concentration and solvent affecting the complexation reaction were carefully studied and optimized. The method is validated as per the International Conference on Harmonisation guideline. The method is successfully applied to the determination of Ni(II) in synthetic mixture and wadi water samples collected from Al Rustaq. The same water samples are also analyzed by atomic absorption spectrophotometry. Both methods determined the amount of Ni(II) in water sample and found to be approximately the same.
authors.affiliation: Department of Applied Sciences, Chemistry Section, Higher College of Technology, Al-Khuwair-133, P O Box 74, Muscat, Sultanate of Oman. snhazmi@yahoo.com
authors.forename: Syed Najmul Hejaz
authors.initials: SN
authors.lastname: Azmi
authors.forename: Bashir
authors.initials: B
authors.lastname: Iqbal
authors.forename: Reem Saif
authors.initials: RS
authors.lastname: Al Khanbashi
authors.forename: Nadia Humaid
authors.initials: NH
authors.lastname: Al Hamhami
authors.forename: Nafisur
authors.initials: N
authors.lastname: Rahman
mesh_terms: D020682:Cefixime / Q000737:chemistry*; D004784:Environmental Monitoring / Q000379:methods*; D008956:Models, Chemical; D009532:Nickel / Q000032:analysis* / Q000737:chemistry; D014874:Water Pollutants, Chemical / Q000032:analysis* / Q000737:chemistry
chemical_list: D014874:Water Pollutants, Chemical; D009532:Nickel; D020682:Cefixime