title: The effect of atypical antipsychotic medications in individuals with anorexia nervosa: a systematic review and meta-analysis.
abstract: OBJECTIVE
  Given that atypical antipsychotic medications have been increasingly prescribed for improving weight gain in anorexia nervosa (AN), we conducted a systematic review and meta-analyses to estimate the influence of atypical antipsychotics on BMI, eating disorder, and psychiatric symptoms in individuals with AN.
  
  
  METHODS
  Independent reviewers selected studies and extracted study characteristics, methodologic quality, and outcomes for the intention-to-treat group from randomized clinical trials comparing the effect of atypical antipsychotic use to placebo or an active control treatment on BMI.
  
  
  RESULTS
  Compared with placebo, atypical antipsychotics were associated with a nonsignificant increase in BMI (weighted mean difference, WMD = 0.18, 95% CI: -0.36, 0.72; I(2) = 26%) and a nonsignificant effect on the drive for thinness and body dissatisfaction. Compared with placebo or active control, these medications led to an increase in anxiety and overall eating disorder symptoms. However, there was a significant reduction over placebo or active control on level of depression.
authors.affiliation: Department of Psychiatry and Psychology, Mayo Clinic, Minnesota 55905, USA.
authors.forename: Jocelyn
authors.initials: J
authors.lastname: Lebow
authors.forename: Leslie A
authors.initials: LA
authors.lastname: Sim
authors.forename: Patricia J
authors.initials: PJ
authors.lastname: Erwin
authors.forename: M Hassan
authors.initials: MH
authors.lastname: Murad
mesh_terms: D000328:Adult; D000856:Anorexia Nervosa / Q000188:drug therapy*; D014150:Antipsychotic Agents / Q000494:pharmacology / Q000627:therapeutic use*; D001835:Body Weight / Q000187:drug effects*; D006801:Humans; D016896:Treatment Outcome; D015430:Weight Gain / Q000187:drug effects
chemical_list: D014150:Antipsychotic Agents