title: A nonmetal approach to α-heterofunctionalized carbonyl derivatives by formal reductive X-H insertion.
abstract: Keeping it organic: A direct synthesis of α-alkoxy and α-amino ester derivatives by direct reductive coupling of widely available, stable α-keto esters and protic pronucleophiles is described (see scheme; X = OR, NR(2)). The method serves as a convenient nonmetal alternative to X-H insertion by diazo decomposition.
authors.affiliation: Department of Chemistry, Pennsylvania State University, University Park, PA 16802, USA.
authors.forename: Eric J
authors.initials: EJ
authors.lastname: Miller
authors.forename: Wei
authors.initials: W
authors.lastname: Zhao
authors.forename: Jonathan D
authors.initials: JD
authors.lastname: Herr
authors.forename: Alexander T
authors.initials: AT
authors.lastname: Radosevich