title: The nucleolus and herpesviral usurpation.
abstract: The nucleolus is a distinct subnuclear compartment known as the site for ribosome biogenesis in eukaryotes. Consequently, the nucleolus is also proposed to function in cell-cycle control, stress sensing and senescence, as well as in viral infection. An increasing number of viral proteins have been found to localize to the nucleolus. In this article, we review the current understanding of the functions of the nucleolus, the molecular mechanism of cellular and viral protein targeting to the nucleolus and the functional roles of the nucleolus during viral infection with a specific focus on the herpesvirus family.
authors.affiliation: Molecular Virology and Viral Immunology Research Group, State Key Laboratory of Virology, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan 430071, PR China.
authors.forename: Liwen
authors.initials: L
authors.lastname: Ni
authors.affiliation: Molecular Virology and Viral Immunology Research Group, State Key Laboratory of Virology, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan 430071, PR China.
authors.forename: Shuai
authors.initials: S
authors.lastname: Wang
authors.affiliation: Molecular Virology and Viral Immunology Research Group, State Key Laboratory of Virology, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan 430071, PR China.
authors.forename: Chunfu
authors.initials: C
authors.lastname: Zheng
mesh_terms: D000818:Animals; D059447:Cell Cycle Checkpoints; D002466:Cell Nucleolus / Q000378:metabolism*; D006564:Herpesviridae / Q000378:metabolism*; D006566:Herpesviridae Infections / Q000378:metabolism* / Q000821:virology*; D006801:Humans; D021381:Protein Transport; D012270:Ribosomes / Q000378:metabolism; D014764:Viral Proteins / Q000378:metabolism*
chemical_list: D014764:Viral Proteins