title: Galectin 3 complements BNP in risk stratification in acute heart failure.
abstract: BACKGROUND
  Galectin 3 (G3) is a mediator of fibrosis and remodeling in heart failure.
  
  
  METHODS
  Patients diagnosed with and treated for Acute Heart Failure Syndromes were prospectively enrolled in the Decision Making in Acute Decompensated Heart Failure multicenter trial.
  
  
  RESULTS
  Patients with a higher G3 had a history of renal disease, a lower heart rate and acute kidney injury. They also tended to have a history of HF and 30-day adverse events compared with B-type natriuretic peptide.
  
  
  CONCLUSIONS
  In Acute Heart Failure Syndromes, G3 levels do not provide prognostic value, but when used complementary to B-type natriuretic peptide, G3 is associated with renal dysfunction and may predict 30-day events.
authors.affiliation: Department of Emergency Medicine, University of Cincinnati, Cincinnati, OH 34267-0769, USA. gregory.fermann@uc.edu
authors.forename: Gregory J
authors.initials: GJ
authors.lastname: Fermann
authors.forename: Christopher J
authors.initials: CJ
authors.lastname: Lindsell
authors.forename: Alan B
authors.initials: AB
authors.lastname: Storrow
authors.forename: Kimberly
authors.initials: K
authors.lastname: Hart
authors.forename: Matthew
authors.initials: M
authors.lastname: Sperling
authors.forename: Susan
authors.initials: S
authors.lastname: Roll
authors.forename: Neal L
authors.initials: NL
authors.lastname: Weintraub
authors.forename: Karen F
authors.initials: KF
authors.lastname: Miller
authors.forename: David J
authors.initials: DJ
authors.lastname: Maron
authors.forename: Allen J
authors.initials: AJ
authors.lastname: Naftilan
authors.forename: John A
authors.initials: JA
authors.lastname: McPherson
authors.forename: Douglas B
authors.initials: DB
authors.lastname: Sawyer
authors.forename: Robert
authors.initials: R
authors.lastname: Christenson
authors.forename: Sean P
authors.initials: SP
authors.lastname: Collins
mesh_terms: D000208:Acute Disease; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015415:Biomarkers / Q000097:blood*; D005260:Female; D037502:Galectin 3 / Q000097:blood*; D006333:Heart Failure / Q000097:blood* / Q000175:diagnosis / Q000628:therapy; D006801:Humans; D008297:Male; D008875:Middle Aged; D020097:Natriuretic Peptide, Brain / Q000097:blood*; D017063:Outcome Assessment, Health Care; D011379:Prognosis; D011446:Prospective Studies; D018570:Risk Assessment; D012307:Risk Factors; D013577:Syndrome
chemical_list: D015415:Biomarkers; D037502:Galectin 3; D020097:Natriuretic Peptide, Brain