title: Measuring the longitudinal relaxation time of GABA in vivo at 3 Tesla.
abstract: OBJECTIVE
  To measure the in vivo longitudinal relaxation time T1 of GABA at 3 Tesla (T).
  
  
  METHODS
  J-difference edited single-voxel MR spectroscopy was used to isolate γ-aminobutyric acid (GABA) signals. An increased echo time (80 ms) acquisition was used, accommodating the longer, more selective editing pulses required for symmetric editing-based suppression of co-edited macromolecular signal. Acquiring edited GABA measurements at a range of relaxation times in 10 healthy participants, a saturation-recovery equation was used to model the integrated data.
  
  
  RESULTS
  The longitudinal relaxation time of GABA was measured as T(1,GABA) = 1.31 ± 0.16 s.
  
  
  CONCLUSIONS
  The method described has been successfully applied to measure the T1 of GABA in vivo at 3T.
authors.affiliation: Russel H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA.
authors.forename: Nicolaas A J
authors.initials: NA
authors.lastname: Puts
authors.forename: Peter B
authors.initials: PB
authors.lastname: Barker
authors.forename: Richard A E
authors.initials: RA
authors.lastname: Edden
mesh_terms: D000328:Adult; D016477:Artifacts; D005260:Female; D006801:Humans; D007089:Image Enhancement / Q000379:methods*; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D009682:Magnetic Resonance Spectroscopy / Q000379:methods*; D008297:Male; D015233:Models, Statistical; D010296:Parietal Lobe / Q000737:chemistry*; D019047:Phantoms, Imaging; D005680:gamma-Aminobutyric Acid / Q000032:analysis*
chemical_list: D005680:gamma-Aminobutyric Acid