title: Correlation of neutrophil to lymphocyte ratio with the presence and severity of metabolic syndrome.
abstract: OBJECTIVE
  The aim of this study is to investigate the relationship between the criteria comprising metabolic syndrome (MS) and neutrophil-lymphocyte ratio (NLR), a simple and reliable indicator of inflammation.
  
  
  METHODS
  Seventy patients with MS and 71 age- and sex-matched control participants were included. Patients were classified into 3 groups based on the number of MS criteria: group 1 (with 3 criteria), group 2 (with 4 criteria), and group 3 (with 5 criteria). The NLR was calculated from complete blood count.
  
  
  RESULTS
  Patients with MS had significantly higher NLR compared to the control group. Moreover, the group 3 patients had higher NLR than those in groups 2 and 1 (P = .008 and P = .078, respectively), whereas there was no difference between the patients meeting 3 and 4 MS criteria (P = .320). Besides, NLR increased as the severity of MS increased (r = .586, P < .001). The cutoff level for NLR with optimal sensitivity and specificity was calculated as 1.84. Serum glucose and high-sensitive C-reactive protein level were found to be independent predictors of an NLR value greater than 1.84.
  
  
  CONCLUSIONS
  The present study indicated a significant correlation between the criteria of MS and inflammation on the basis of NLR. Furthermore, there an increase in NLR as the severity of MS increases.
authors.affiliation: 1Department of Cardiology, Mustafa Kemal University School of Medicine, Hatay, Turkey.
authors.forename: Eyup
authors.initials: E
authors.lastname: Buyukkaya
authors.forename: Mehmet Fatih
authors.initials: MF
authors.lastname: Karakas
authors.forename: Esra
authors.initials: E
authors.lastname: Karakas
authors.forename: Adnan Burak
authors.initials: AB
authors.lastname: Akçay
authors.forename: Ibrahim Halil
authors.initials: IH
authors.lastname: Tanboga
authors.forename: Mustafa
authors.initials: M
authors.lastname: Kurt
authors.forename: Nihat
authors.initials: N
authors.lastname: Sen
mesh_terms: D002097:C-Reactive Protein / Q000276:immunology; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D007249:Inflammation / Q000097:blood; D008214:Lymphocytes / Q000276:immunology / Q000473:pathology*; D008297:Male; D024821:Metabolic Syndrome / Q000097:blood* / Q000145:classification; D008875:Middle Aged; D009504:Neutrophils / Q000276:immunology / Q000473:pathology*
chemical_list: D002097:C-Reactive Protein