title: Synthesis and cellular compatibility of Co-doped ZnO particles in silk-fibroin peptides.
abstract: Co-doped ZnO particles were successfully prepared via a facile biomineralization process in the template of silk-fibroin (SF) peptides at room temperature, and SF peptides were coated onto the surface of particles. The ratio of Zn/Co in reactive solution could substantially influence the morphology of as-prepared particles, and the rough spherical particles including some nanoparticles of 50 nm diameters could be obtained at 4:1 ratio of Zn/Co. The saturation magnetization of SF-coated Co-ZnO particles was 8.63 emu/g, much larger than that of Co-ZnO without SF. L929 cell test revealed that the Co-doped ZnO particles had a good cellular compatibility at the concentration of less than 0.25 mg/mL due to silk-peptide coating, indicating that the prepared Co-doped ZnO particles have a potential for the biomedical applications.
authors.affiliation: College of Materials Science and Engineering, Sichuan University, Chengdu, 610065, China.
authors.forename: Yuanwen
authors.initials: Y
authors.lastname: Zou
authors.forename: Zhongbing
authors.initials: Z
authors.lastname: Huang
authors.forename: Yan
authors.initials: Y
authors.lastname: Wang
authors.forename: Xiaoming
authors.initials: X
authors.lastname: Liao
authors.forename: Guangfu
authors.initials: G
authors.lastname: Yin
authors.forename: Jianwen
authors.initials: J
authors.lastname: Gu
mesh_terms: D002460:Cell Line / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D005349:Fibroins / Q000737:chemistry*; D006801:Humans; D008956:Models, Chemical; D053758:Nanoparticles / Q000009:adverse effects / Q000737:chemistry*; D010455:Peptides / Q000737:chemistry*; D047011:Silk / Q000737:chemistry*; D015034:Zinc Oxide / Q000737:chemistry*
chemical_list: D010455:Peptides; D047011:Silk; D005349:Fibroins; D015034:Zinc Oxide