title: Decision making and management of gliomas: practical considerations.
abstract: Over the last decade, diagnostic options and introduction of novel treatments have expanded the armamentarium in the management of malignant glioma. Combined chemoradiotherapy has become the standard of care in glioblastoma up to the age of 70 years, while treatment in elderly patients or with lower grade glioma is less well defined. Molecular markers define different disease subtypes and allow for adapted treatment selection. This review focuses on simple questions arising in the daily management of patients.
authors.affiliation: Department of Clinical Neurosciences Centre Hospitalier Universitaire Vaudois and University of Lausanne, Switzerland.
authors.forename: A F
authors.initials: AF
authors.lastname: Hottinger
authors.forename: K
authors.initials: K
authors.lastname: Homicsko
authors.forename: L
authors.initials: L
authors.lastname: Negretti
authors.forename: B
authors.initials: B
authors.lastname: Lhermitte
authors.forename: R
authors.initials: R
authors.lastname: Stupp
mesh_terms: D000368:Aged; D001254:Astrocytoma / Q000188:drug therapy / Q000473:pathology; D014408:Biomarkers, Tumor / Q000032:analysis; D001932:Brain Neoplasms / Q000188:drug therapy / Q000473:pathology; D015254:DNA Modification Methylases / Q000032:analysis; D045643:DNA Repair Enzymes / Q000032:analysis; D003606:Dacarbazine / Q000031:analogs & derivatives / Q000627:therapeutic use; D005909:Glioblastoma / Q000188:drug therapy / Q000473:pathology; D006801:Humans; D007521:Isocitrate Dehydrogenase / Q000378:metabolism; D015201:Meta-Analysis as Topic; D009837:Oligodendroglioma / Q000188:drug therapy / Q000473:pathology; D000077204:Temozolomide; D025521:Tumor Suppressor Proteins / Q000032:analysis
chemical_list: D014408:Biomarkers, Tumor; D025521:Tumor Suppressor Proteins; D003606:Dacarbazine; D007521:Isocitrate Dehydrogenase; C543588:IDH1 protein, human; D015254:DNA Modification Methylases; C515491:MGMT protein, human; D045643:DNA Repair Enzymes; D000077204:Temozolomide