title: [A case of paclitaxel-induced peripheral neuropathy successfully treated with pregabalin].
abstract: Were port a 51-year-old male left renal pelvic cancer patient with paclitaxel (PTX)-induced peripheral neuropathy, which was successfully treated with pregabalin. From June 2010, a gemcitabine/PTX (GP) regimen was used as third-line treatment. In order to relieve the PTX-induced peripheral neuropathy, pregabalin (75mg/day, at night) was administered from day 6 of the 16th course. Moreover, pregabalin was increased to 150mg/day from day 12 of the course. Sensory neurotoxicity after the administration of pregabalin was decreased from CTCAE (version 4. 0) grade 3 to 1 at day 19 of the course. Therefore, there is a possibility that the PTX -induced peripheral neuropathy may be improved by pregabalin administration. Further trials may be needed to confirm the value of pregabalin.
authors.affiliation: Dept. of Pharmacy, National Hospital Organization Kure Medical Center and Chugoku Cancer Center.
authors.forename: Toshihisa
authors.initials: T
authors.lastname: Nakashima
authors.forename: Takayoshi
authors.initials: T
authors.lastname: Kiba
authors.forename: Yoshikazu
authors.initials: Y
authors.lastname: Ogawa
authors.forename: Atsuko
authors.initials: A
authors.lastname: Hosokawa
authors.forename: Hiromi
authors.initials: H
authors.lastname: Shintani
authors.forename: Yuuko
authors.initials: Y
authors.lastname: Okada
authors.forename: Takako
authors.initials: T
authors.lastname: Taniguchi
authors.forename: Masanobu
authors.initials: M
authors.lastname: Shigeta
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Kozawa
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D006801:Humans; D007680:Kidney Neoplasms / Q000188:drug therapy / Q000473:pathology / Q000601:surgery; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D017239:Paclitaxel / Q000008:administration & dosage / Q000009:adverse effects*; D010523:Peripheral Nervous System Diseases / Q000139:chemically induced / Q000188:drug therapy*; D000069583:Pregabalin; D005680:gamma-Aminobutyric Acid / Q000031:analogs & derivatives* / Q000627:therapeutic use
chemical_list: D000069583:Pregabalin; D005680:gamma-Aminobutyric Acid; D017239:Paclitaxel