title: Kinetic control of nucleosome displacement by ISWI/ACF chromatin remodelers.
abstract: Chromatin structure is dynamically organized by chromatin remodelers, motor protein complexes which move and remove nucleosomes. The regulation of remodeler action has recently been proposed to underlie a kinetic proofreading scheme which combines the recognition of histone-tail states and the ATP-dependent loosening of DNA around nucleosomes. Members of the ISWI-family of remodelers additionally recognize linker length between nucleosomes. Here, we show that the additional proofreading step involving linker length alone is sufficient to promote the formation of regular arrays of nucleosomes. ATP-dependent remodeling by bidirectional motors is shown to reinforce positioning as compared to statistical positioning.
authors.affiliation: Max-Planck Institute for the Physics of Complex Systems, Nöthnitzer Strasse 38, D-01187 Dresden, Germany.
authors.forename: Ana-Maria
authors.initials: AM
authors.lastname: Florescu
authors.forename: Helmut
authors.initials: H
authors.lastname: Schiessel
authors.forename: Ralf
authors.initials: R
authors.lastname: Blossey
mesh_terms: D000251:Adenosine Triphosphatases / Q000235:genetics* / Q000378:metabolism; D000255:Adenosine Triphosphate / Q000378:metabolism; D042002:Chromatin Assembly and Disassembly / Q000235:genetics*; D004247:DNA / Q000235:genetics / Q000378:metabolism; D056488:Histone Chaperones / Q000235:genetics* / Q000378:metabolism; D007700:Kinetics; D008957:Models, Genetic; D009707:Nucleosomes / Q000235:genetics* / Q000378:metabolism; D014157:Transcription Factors / Q000235:genetics* / Q000378:metabolism
chemical_list: D056488:Histone Chaperones; C086468:ISWI protein; D009707:Nucleosomes; D014157:Transcription Factors; D000255:Adenosine Triphosphate; D004247:DNA; D000251:Adenosine Triphosphatases