title: High nuclear protein kinase CβII expression is a marker of disease recurrence in oral squamous cell carcinoma.
abstract: BACKGROUND
  Protein kinase C beta II (PKCβII) is a member of the family of serine/threonine kinases which are involved in tumor formation and progression. This study investigated the significance of PKCβII in oral squamous cell carcinoma (OSCC).
  
  
  METHODS
  The expression of PKCβII was determined in tumors from 59 patients with OSCC using immunohistochemistry and was correlated with patients' clinical characteristics and outcomes.
  
  
  RESULTS
  Twenty-six cases (44%) exhibited nuclear PKCβII staining. High nuclear PKCβII expression was significantly associated with the consumption of betel quid (p=0.015) and alcohol (p=0.024) in OSCC. Kaplan-Meier analysis revealed a shorter time-to-recurrence in patients with high nuclear PKCβII expression (p=0.018). In multivariate analysis for recurrence, high nuclear staining of PKCβII remained an independent adverse prognostic factor (hazard ratio=2.3, p=0.016).
  
  
  CONCLUSIONS
  The present study provides evidence of the potential prognostic value of PKCβII analysis in OSCC.
authors.affiliation: Department of Pathology, St Martin De Porres Hospital, Chiayi, Taiwan, ROC.
authors.forename: Pei-Yi
authors.initials: PY
authors.lastname: Chu
authors.forename: Nicholas Chung-Heng
authors.initials: NC
authors.lastname: Hsu
authors.forename: Shu-Hui
authors.initials: SH
authors.lastname: Lin
authors.forename: Ming-Feng
authors.initials: MF
authors.lastname: Hou
authors.forename: Kun-Tu
authors.initials: KT
authors.lastname: Yeh
mesh_terms: D014408:Biomarkers, Tumor / Q000096:biosynthesis*; D002294:Carcinoma, Squamous Cell / Q000201:enzymology* / Q000473:pathology; D002467:Cell Nucleus / Q000201:enzymology; D005260:Female; D006801:Humans; D008297:Male; D009062:Mouth Neoplasms / Q000201:enzymology* / Q000473:pathology; D009364:Neoplasm Recurrence, Local / Q000201:enzymology* / Q000473:pathology; D016612:Paraffin Embedding; D011493:Protein Kinase C / Q000096:biosynthesis*; D064546:Protein Kinase C beta; D012189:Retrospective Studies
chemical_list: D014408:Biomarkers, Tumor; D011493:Protein Kinase C; D064546:Protein Kinase C beta