title: [A case of large cell neuroendocrine carcinoma (LCNEC) of the uterine cervix successfully treated by postoperative CPT-11+CDDP chemotherapy after non-curative surgery].
abstract: A 31-year-old woman, gravida 3 para 3, visited a local clinic because of post-coital bleeding. She was diagnosed as having a uterine-cervical tumor and was referred to our hospital. Large cell neuroendocrine carcinoma (LCNEC) of the uterine cervix was pathologically shown by biopsy. The patient was initially treated by radical hysterectomy. Postoperative pathological examination revealed a direct invasion to the parametrium and the positive resection margin. Postoperatively, she was treated by CPT-11+CDDP. One course of treatment was 60mg/m² of CPT-11 administered on day 1, 8 and 15, and 60 mg/m² of CDDP on day 1, with an intermission after administration for 7 days. Six courses were carried out. This treatment resulted in complete remission. A follow-up at the outpatient clinic revealed the patient had been tumor-free for one year and three months after the first treatment. We suggest that postoperative chemotherapy with CPT-11+CDDP might be useful in the treatment of patients with LCNEC of the uterine cervix.
authors.affiliation: Dept. of Obstetrics and Gynecology, Hiroshima City Asa Hospital.
authors.forename: Hirotoshi
authors.initials: H
authors.lastname: Tanimoto
authors.forename: Aki
authors.initials: A
authors.lastname: Hamasaki
authors.forename: Yumiko
authors.initials: Y
authors.lastname: Akimoto
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Honda
authors.forename: Yuko
authors.initials: Y
authors.lastname: Takao
authors.forename: Kei
authors.initials: K
authors.lastname: Okamoto
authors.forename: Mitsue
authors.initials: M
authors.lastname: Teramoto
authors.forename: Hideki
authors.initials: H
authors.lastname: Teramoto
authors.forename: Mayumi
authors.initials: M
authors.lastname: Kaneko
authors.forename: Takafumi
authors.initials: T
authors.lastname: Oshita
mesh_terms: D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D002166:Camptothecin / Q000008:administration & dosage / Q000031:analogs & derivatives; D018287:Carcinoma, Large Cell / Q000188:drug therapy* / Q000473:pathology / Q000601:surgery; D018278:Carcinoma, Neuroendocrine / Q000188:drug therapy* / Q000473:pathology / Q000601:surgery; D002945:Cisplatin / Q000008:administration & dosage; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D000077146:Irinotecan; D009361:Neoplasm Invasiveness; D014057:Tomography, X-Ray Computed; D002583:Uterine Cervical Neoplasms / Q000188:drug therapy* / Q000473:pathology / Q000601:surgery
chemical_list: D000077146:Irinotecan; D002945:Cisplatin; D002166:Camptothecin