title: Cardiac output obtained from test bolus injections as a factor in contrast injection rate revision of following coronary CT angiography.
abstract: BACKGROUND
  Optimal contrast enhancement is crucial for the detection of coronary artery stenoses and atherosclerotic changes in coronary CT angiography (CTA).
  
  
  OBJECTIVE
  To demonstrate the feasibility of using the cardiac output (CO) obtained from the test bolus injection data-set (COtest) as a factor in contrast injection rate revision of the following coronary CTA.
  
  
  METHODS
  The test bolus injection data-sets of 52 consecutive coronary CTAs were examined. COtest was calculated from the test bolus data-set. Aortic peak enhancement (APE) was measured on the following coronary CTA. We simulated the APE at a fixed contrast injection rate of 4 mL/s (simAPE) in each patient.
  
  
  RESULTS
  The ranges of COtest and simAPE were 2.82-7.56 L/min and 194-527 Hounsfield Units, respectively. There was a significant negative correlation (R = -0.802, P < 0.001) between simAPE and COtest.
  
  
  CONCLUSIONS
  COtest can be used for injection rate revision on coronary CTA.
authors.affiliation: Division of Diagnostic Image Analysis, Graduate School of Medicine, Tohoku University, Miyagi, Japan. mkonno@med.tohoku.ac.jp
authors.forename: Masahiko
authors.initials: M
authors.lastname: Konno
authors.forename: Yoshiyuki
authors.initials: Y
authors.lastname: Hosokai
authors.forename: Akihito
authors.initials: A
authors.lastname: Usui
authors.forename: Mitsuya
authors.initials: M
authors.lastname: Abe
authors.forename: Toshiki
authors.initials: T
authors.lastname: Tateishi
authors.forename: Yusuke
authors.initials: Y
authors.lastname: Kawasumi
authors.forename: Masashi
authors.initials: M
authors.lastname: Tsuda
authors.forename: Hideki
authors.initials: H
authors.lastname: Ota
authors.forename: Kei
authors.initials: K
authors.lastname: Takase
authors.forename: Haruo
authors.initials: H
authors.lastname: Saito
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002302:Cardiac Output; D003287:Contrast Media / Q000008:administration & dosage*; D017023:Coronary Angiography / Q000379:methods*; D005240:Feasibility Studies; D005260:Female; D006801:Humans; D007472:Iohexol / Q000008:administration & dosage*; D008297:Male; D008875:Middle Aged; D017202:Myocardial Ischemia / Q000000981:diagnostic imaging*; D012189:Retrospective Studies; D014057:Tomography, X-Ray Computed / Q000379:methods*; D055815:Young Adult
chemical_list: D003287:Contrast Media; D007472:Iohexol