title: Radioembolization of the spleen: a revisited approach for the treatment of malignant lymphomatous splenomegaly.
abstract: Intraarterial administration of (90)Y microspheres to the spleen in patients with malignant lymphoma was mentioned once in the literature in 1973. This case study illustrates the potential indication of selective internal radiotherapy in a heavily pretreated patient with highly refractory disease with a marginal zone lymphoma in leukemic phase and symptomatic splenomegaly. We describe the clinical course of disease; the biological and clinical response to the treatment after radioembolization; and simulation and dosimetry by multimodal imaging via single-photon emission computed tomography and computed tomography. The advantages of radioembolization for the management of lymphomatous splenomegaly are discussed.
authors.affiliation: Department of Nuclear Medicine, Jules Bordet Institute, ULB, Héger Bordetstraat 1, 1000, Brussels, Belgium. kristoff.muylle@bordet.be
authors.forename: Kristoff
authors.initials: K
authors.lastname: Muylle
authors.forename: Jasmine
authors.initials: J
authors.lastname: Nguyen
authors.forename: Alexandre
authors.initials: A
authors.lastname: de Wind
authors.forename: Nathalie
authors.initials: N
authors.lastname: Meuleman
authors.forename: Philippe
authors.initials: P
authors.lastname: Delatte
authors.forename: Bruno
authors.initials: B
authors.lastname: Vanderlinden
authors.forename: Martine
authors.initials: M
authors.lastname: Roelandts
authors.forename: Anja
authors.initials: A
authors.lastname: Van der Stappen
authors.forename: Dominique
authors.initials: D
authors.lastname: Bron
authors.forename: Patrick
authors.initials: P
authors.lastname: Flamen
mesh_terms: D000368:Aged; D001707:Biopsy, Needle; D018450:Disease Progression; D004621:Embolization, Therapeutic / Q000379:methods; D017809:Fatal Outcome; D006801:Humans; D007150:Immunohistochemistry; D008223:Lymphoma / Q000000981:diagnostic imaging / Q000473:pathology / Q000532:radiotherapy*; D008297:Male; D008863:Microspheres; D064847:Multimodal Imaging / Q000379:methods*; D011829:Radiation Dosage; D019275:Radiopharmaceuticals / Q000627:therapeutic use; D013154:Spleen / Q000000981:diagnostic imaging / Q000473:pathology; D013156:Splenectomy / Q000379:methods; D013163:Splenomegaly / Q000000981:diagnostic imaging / Q000473:pathology* / Q000532:radiotherapy* / Q000601:surgery; D015899:Tomography, Emission-Computed, Single-Photon / Q000379:methods; D014057:Tomography, X-Ray Computed / Q000379:methods; D015021:Yttrium Radioisotopes / Q000627:therapeutic use*
chemical_list: D019275:Radiopharmaceuticals; D015021:Yttrium Radioisotopes