title: Molecular mediators of favism-induced acute kidney injury.
abstract: Intolerance to fava beans in subjects with glucose-6-phosphate-dehydrogenase deficiency (favism) may lead to severe hemolytic crises and decreased renal function. Renal biopsy findings exploring the molecular mechanisms of renal damage in favism have not been previously reported. We report a case of favism-associated acute kidney injury in which renal biopsy showed acute tubular necrosis and massive iron deposits in tubular cells. Interestingly, iron deposit areas were characterized by the presence of oxidative stress markers (NADPH-p22 phox and heme-oxigenase-1) and macrophages expressing the hemoglobin scavenger receptor CD163. In addition, iron deposits, NADPH-p22 phox, hemeoxigenase- 1 and CD163 positive cells were observed in some glomeruli. These results identify both glomerular and tubular involvement in favism-associated acute kidney injury and suggest novel therapeutic targets to prevent or accelerate recovery from acute kidney injury.
authors.forename: Rosa María
authors.initials: RM
authors.lastname: García-Camín
authors.forename: Montserrat
authors.initials: M
authors.lastname: Goma
authors.forename: Rosa García
authors.initials: RG
authors.lastname: Osuna
authors.forename: Alfonso
authors.initials: A
authors.lastname: Rubio-Navarro
authors.forename: Irene
authors.initials: I
authors.lastname: Buendía
authors.forename: Alberto
authors.initials: A
authors.lastname: Ortiz
authors.forename: Jesús
authors.initials: J
authors.lastname: Egido
authors.forename: Félix
authors.initials: F
authors.lastname: Manzarbeitia
authors.forename: Julio Leonel
authors.initials: JL
authors.lastname: Chevarria
authors.forename: María Constanza
authors.initials: MC
authors.lastname: Gluksmann
authors.forename: Juan Antonio
authors.initials: JA
authors.lastname: Moreno
mesh_terms: D058186:Acute Kidney Injury / Q000175:diagnosis / Q000209:etiology* / Q000378:metabolism / Q000628:therapy; D015703:Antigens, CD / Q000032:analysis; D015214:Antigens, Differentiation, Myelomonocytic / Q000032:analysis; D015415:Biomarkers / Q000032:analysis; D001706:Biopsy; D005236:Favism / Q000150:complications* / Q000175:diagnosis; D051547:Heme Oxygenase-1 / Q000032:analysis; D006801:Humans; D007150:Immunohistochemistry; D007678:Kidney Glomerulus / Q000737:chemistry* / Q000473:pathology; D007683:Kidney Tubular Necrosis, Acute / Q000209:etiology / Q000378:metabolism; D007684:Kidney Tubules / Q000737:chemistry* / Q000473:pathology; D008264:Macrophages / Q000737:chemistry; D008297:Male; D008875:Middle Aged; D019255:NADPH Oxidases / Q000032:analysis; D011956:Receptors, Cell Surface / Q000032:analysis; D006435:Renal Dialysis; D013997:Time Factors; D016896:Treatment Outcome; D000098902:CD163 Antigen
chemical_list: D015703:Antigens, CD; D015214:Antigens, Differentiation, Myelomonocytic; D015415:Biomarkers; D000098902:CD163 Antigen; D011956:Receptors, Cell Surface; C496541:HMOX1 protein, human; D051547:Heme Oxygenase-1; D019255:NADPH Oxidases; C086986:CYBA protein, human