title: Future therapies for Hirschsprung's disease.
abstract: The current management of Hirschsprung's disease (HSCR) is still associated with significant long-term morbidities despite on-going refinements in surgical care. Over the course of the past 20 years, significant inroads have been made in our understanding of the development of the enteric nervous system and what factors are responsible for the development of HSCR. This has prompted increased interest in the possibility of using this knowledge to develop new alternative and adjunctive therapies for HSCR. The aim of this review is to provide an overview of the current progress being made toward the development of future therapies to improve the outcome for children with HSCR.
authors.affiliation: Department of Paediatric Surgery, Alder Hey Children's NHS Foundation Trust, Liverpool, UK.
authors.forename: David J
authors.initials: DJ
authors.lastname: Wilkinson
authors.forename: David H
authors.initials: DH
authors.lastname: Edgar
authors.forename: Simon E
authors.initials: SE
authors.lastname: Kenny
mesh_terms: D053595:Embryonic Stem Cells / Q000637:transplantation*; D046128:Fetal Therapies; D005819:Genetic Markers; D006627:Hirschsprung Disease / Q000175:diagnosis / Q000196:embryology / Q000235:genetics / Q000601:surgery*; D006801:Humans; D007422:Intestines / Q000196:embryology / Q000294:innervation / Q000473:pathology / Q000601:surgery; D058953:Neural Stem Cells / Q000637:transplantation*; D011296:Prenatal Diagnosis; D014182:Transplantation, Autologous
chemical_list: D005819:Genetic Markers