title: Contrast-enhanced ultrasound analysis of renal perfusion in normal micropigs.
abstract: Contrast-enhanced ultrasound is one of method for evaluating renal perfusion. The purpose of this project was to assess perfusion patterns and dynamics in normal micropig kidney using ultrasonographic contrast media. Eight young healthy micropigs were included in this study. Micropigs were anesthetized with propofol and received an intravenous bolus of microbubble contrast media through an ear vein. Time/mean pixel value (MPV) curves were generated for selected regions in the right renal cortex and medulla. The parenchyma was enhanced in two phases. The cortex was first enhanced followed by a more gradual enhancement of the medulla. A significant difference in perfusion was detected between the cortex and medulla. Following the bolus injection, the average upslope was 0.68 ± 0.27 MPV/sec, downslope was -0.27 ± 0.13 MPV/sec, baseline was 73.9 ± 16.5 MPV, peak was 84.6 ± 17.2 MPV, and time-to-peak (from injection) was 17.5 ± 6.6 sec for the cortex. For the medulla, the average upslope was 0.50 ± 0.24 MPV/sec, downslope was -0.12 ± 0.06 MPV/sec, baseline was 52.7 ± 7.0 MPV, peak was 65.2 ± 9.3 MPV, and time-to-peak (from injection) was 27.5 ± 5.0 sec. These data can be used as normal reference values for studying young micropigs.
authors.affiliation: Department of Veterinary Medical Imaging, and Research Institute for Veterinary Science, College of Veterinary Medicine, Seoul National University, Seoul 151-742, Korea.
authors.forename: Kangjae
authors.initials: K
authors.lastname: Yi
authors.forename: Seoyeoun
authors.initials: S
authors.lastname: Ji
authors.forename: Junyoung
authors.initials: J
authors.lastname: Kim
authors.forename: Junghee
authors.initials: J
authors.lastname: Yoon
authors.forename: Mincheol
authors.initials: M
authors.lastname: Choi
mesh_terms: D000818:Animals; D003287:Contrast Media; D007091:Image Processing, Computer-Assisted; D007275:Injections, Intravenous / Q000662:veterinary; D007668:Kidney / Q000098:blood supply* / Q000000981:diagnostic imaging; D007677:Kidney Function Tests / Q000662:veterinary; D016014:Linear Models; D045423:Microbubbles / Q000662:veterinary; D012016:Reference Values; D012079:Renal Circulation; D013459:Sulfur Hexafluoride; D013552:Swine; D013556:Swine, Miniature / Q000502:physiology*; D014463:Ultrasonography / Q000379:methods* / Q000662:veterinary
chemical_list: D003287:Contrast Media; D013459:Sulfur Hexafluoride