title: Lanostane triterpenoids and sterols from Antrodia camphorata.
abstract: Four lanostane triterpenes, 3,7,11-trioxo-5α-lanosta-8,24(E)-dien-26-oic acid, methyl 11α-3,7-dioxo-5α-lanosta-8,24(E)-dien-26-oate, methyl 3,7,11,12,15,23-hexaoxo-5α-lanost-8-en-26-oate, and ethyl 3,7,11,12,15,23-hexaoxo-5α-lanost-8-en-26-oate, two sterols, (14α,22E)-14-hydroxyergosta-7,22-diene-3,6-dione and a steroid named as camphosterol A were isolated from a mixture of fruiting bodies and mycelia of solid cultures of Antrodia camphorata. The ¹H and ¹³C NMR spectra of all compounds were fully assigned using a combination of 2D NMR experiments, including COSY, HMQC, HMBC and NOESY sequences. Six compounds were evaluated for cytotoxicity against several human tumor cell lines, all of which has moderate activity.
authors.affiliation: Department of Chinese Pharmaceutical Sciences and Chinese Medicine Resources, China Medical University, Taichung 404, Taiwan.
authors.forename: Hui-Chi
authors.initials: HC
authors.lastname: Huang
authors.forename: Chih-Chuang
authors.initials: CC
authors.lastname: Liaw
authors.forename: Hsin-Ling
authors.initials: HL
authors.lastname: Yang
authors.forename: You-Cheng
authors.initials: YC
authors.lastname: Hseu
authors.forename: Hsiou-Ting
authors.initials: HT
authors.lastname: Kuo
authors.forename: Yao-Ching
authors.initials: YC
authors.lastname: Tsai
authors.forename: Shih-Chang
authors.initials: SC
authors.lastname: Chien
authors.forename: Sakae
authors.initials: S
authors.lastname: Amagaya
authors.forename: Yu-Chang
authors.initials: YC
authors.lastname: Chen
authors.forename: Yueh-Hsiung
authors.initials: YH
authors.lastname: Kuo
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D055491:Antrodia / Q000737:chemistry*; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D004354:Drug Screening Assays, Antitumor; D005638:Fruit / Q000737:chemistry; D006801:Humans; D061986:MCF-7 Cells; D015394:Molecular Structure; D025282:Mycelium / Q000737:chemistry; D013261:Sterols / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D013329:Structure-Activity Relationship; D014315:Triterpenes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D013261:Sterols; D014315:Triterpenes