title: Designing a vaccination strategy against dengue.
abstract: In this work we propose a mathematical approach to estimate the dengue force of infection, the average age of dengue first infection, the optimum age to vaccinate children against dengue in a routine fashion and the optimum age interval to introduce the dengue vaccine in a mass vaccination campaign. The model is based on previously published models for vaccination against other childhood infections, which resulted in actual vaccination programmes in Brazil. The model was applied for three areas of distinct levels of endemicity of the city of Recife in Northeastern State of Pernambuco, Brazil. Our results point to an optimal age to introduce the dengue vaccine in the routine immunization programme at two years of age and an age interval to introduce a mass vaccination between three and 14 years of age.
authors.affiliation: School of Veterinary Medicine, University of São Paulo, Brazil.
authors.forename: Marcos
authors.initials: M
authors.lastname: Amaku
authors.forename: Laurent
authors.initials: L
authors.lastname: Coudeville
authors.forename: Eduardo
authors.initials: E
authors.lastname: Massad
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D001938:Brazil; D002648:Child; D002675:Child, Preschool; D003715:Dengue / Q000517:prevention & control*; D053059:Dengue Vaccines / Q000008:administration & dosage*; D003716:Dengue Virus / Q000276:immunology*; D006801:Humans; D017589:Immunization Programs / Q000458:organization & administration; D007223:Infant; D007231:Infant, Newborn; D008875:Middle Aged; D008962:Models, Theoretical; D016036:Seroepidemiologic Studies; D014611:Vaccination; D055815:Young Adult
chemical_list: D053059:Dengue Vaccines