title: Upregulation of β3-adrenergic receptor expression in the atrium of rats with chronic heart failure.
abstract: OBJECTIVE
  To investigate the expression of β(3)-adrenergic receptor (β(3)-AR) in the atrium of rats with chronic heart failure (CHF).
  
  
  METHODS
  The heart failure rat model was established by aortic constriction. Thirty-six male Wistar rats were divided into Sham group (n = 10) and heart failure model group (n = 26), which were further divided into CHF control (CHF group) and BRL group. The rats in the BRL group were treated with a selective β(3)-AR agonist, BRL-37344 (4.0 nmol/kg, twice weekly) for 4 weeks.
  
  
  RESULTS
  In the BRL group, the left ventricular end-systolic pressure (83.21 ± 13.0 vs 101.50 ± 12.12 mm Hg) and the absolute values of the maximal rate of rise and fall of left ventricular pressure ([±dP/dtmax] 2.81 ± 0.04 vs 0.35 ± 0.04 and -2.72 ± 0.06 vs -3.33 ± 0.06) were lower than in the CHF group (P < .01). The left atrial mass index (LAMI) in the BRL group (0.4132 ± 0.0306) was higher than that in the CHF (0.3212 ± 0.0136) or Sham group (0.2683 ± 0.0145; P < .01). The levels of the left atrial β(3)-AR messenger RNA (mRNA) expression in the BRL group (0.932 ± 0.055) was higher than that in the CHF (0.706 ± 0.043) or Sham group (0.310 ± 0.020; P < .01). In all animals, there was a positive correlation between the level of β(3)-AR mRNA expression and the left or right atrial mass index (correlation coefficient ranged from 0.744 to 0.937).
  
  
  CONCLUSIONS
  There is a significant increase in the β(3)-AR mRNA expression in the atrium of rats with heart failure. The level of β(3)-AR mRNA expression was associated with the AMI and was enhanced by a selective β(3)-AR agonist, BRL-37344.
authors.affiliation: Department of Cardiology, the Red Cross Hospital of Guangzhou City, the Fourth Affiliated Hospital of Jinan University, Guangzhou, People's Republic of China.
authors.forename: Qiang
authors.initials: Q
authors.lastname: Zhao
authors.forename: Fang
authors.initials: F
authors.lastname: Zeng
authors.forename: Jiang-Bo
authors.initials: JB
authors.lastname: Liu
authors.forename: Yun
authors.initials: Y
authors.lastname: He
authors.forename: Biao
authors.initials: B
authors.lastname: Li
authors.forename: Zuo-Feng
authors.initials: ZF
authors.lastname: Jiang
authors.forename: Tong-Guo
authors.initials: TG
authors.lastname: Wu
authors.forename: Le-Xin
authors.initials: LX
authors.lastname: Wang
mesh_terms: D000818:Animals; D002908:Chronic Disease; D006325:Heart Atria / Q000378:metabolism* / Q000473:pathology; D006333:Heart Failure / Q000378:metabolism* / Q000473:pathology; D008297:Male; D012333:RNA, Messenger / Q000096:biosynthesis; D051381:Rats; D017208:Rats, Wistar; D022702:Receptors, Adrenergic, beta-3 / Q000096:biosynthesis* / Q000235:genetics; D015854:Up-Regulation / Q000235:genetics
chemical_list: D012333:RNA, Messenger; D022702:Receptors, Adrenergic, beta-3