title: Asymmetric formal [3+2] cycloaddition reaction of α-aryl isocyanoesters with N-aryl maleimides by bifunctional cinchona alkaloids-based squaramide/AgSbF6 cooperative catalysis.
abstract: It is better to be cooperative: A highly diastereo- and enantioselective asymmetric [3+2] cycloaddition reaction of α-aryl isocyanoacetates with N-aryl maleimides through cooperative catalysis of cinchona alkaloid-derived squaramide/AgSbF(6) was developed. A wide range of optically active, substituted 1,3a,4,5,6,6a-hexahydropyrrolo[3,4-c] pyrrole derivatives was obtained in high yields (up to 98%), high diastereoselectivities (>20:1 d.r.), and good to excellent enantioselectivities (up to 92% ee) under mild reaction conditions.
authors.affiliation: Key Laboratory for Advanced Materials and Institute of Fine Chemicals, East China University of Science and Technology, 130 Meilong Road, Shanghai, 200237, PR China. mxzhao@ecust.edu.cn
authors.forename: Mei-Xin
authors.initials: MX
authors.lastname: Zhao
authors.forename: Deng-Ke
authors.initials: DK
authors.lastname: Wei
authors.forename: Fei-Hu
authors.initials: FH
authors.lastname: Ji
authors.forename: Xiao-Li
authors.initials: XL
authors.lastname: Zhao
authors.forename: Min
authors.initials: M
authors.lastname: Shi