title: Manganese: a new contrast agent for lung imaging?
abstract: Lung parenchyma remains one of the most difficult tissues to be imaged by means of magnetic resonance imaging (MRI). Several MRI techniques are routinely used for lung imaging. However, manganese-enhancement MRI (MEMRI) technique has not been associated with pulmonary MRI. Here, we evaluated T(1) -enhancement in the rat lung after a manganese instillation, using a 4.7 T magnet with a radial ultrashort echo time sequence. Our data showed that the signal intensity was increased in lungs receiving a manganese solution compared with a control solution to the lungs. MR signal enhancements above 30% were measured in lung parenchyma following 200 µl instillation of a 1 mm manganese chloride solution. MEMRI, therefore, may be a useful novel tool for enhancing signal intensity and image contrast in lung tissue.
authors.affiliation: School of Pharmacy and Pharmaceutical Sciences, Trinity College Dublin, Dublin, Ireland.
authors.forename: Oliviero L
authors.initials: OL
authors.lastname: Gobbo
authors.forename: Magdalena
authors.initials: M
authors.lastname: Zurek
authors.forename: Frederic
authors.initials: F
authors.lastname: Tewes
authors.forename: Carsten
authors.initials: C
authors.lastname: Ehrhardt
authors.forename: Yannick
authors.initials: Y
authors.lastname: Crémillieux
mesh_terms: D000818:Animals; D002712:Chlorides; D003287:Contrast Media / Q000737:chemistry; D007089:Image Enhancement; D008168:Lung / Q000473:pathology*; D008279:Magnetic Resonance Imaging; D008297:Male; D017895:Manganese Compounds; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D002712:Chlorides; D003287:Contrast Media; D017895:Manganese Compounds; C025340:manganese chloride