title: [Apnea after general anesthesia for revision of uterus in parturient with K-variant of the butyrylcholinesterase enzyme (BChE)].
abstract: A 30 years old parturient was admitted to the operating theatre for revision of uterus after spontaneous labor because of hemorrhage. She underwent general anesthesia induced by rapid sequence induction (RSI) technique. Apnea for 45 minutes was observed after succinylcholine administration. Biochemistry laboratory tests from the operation day showed very low butyrylcholinesterase activity, and a repeated test after one month showed normal enzyme activity and inhibitors within the normal range. Genetic tests revealed heterozygosity for the K variant of BChE. This may explain the increased sensitivity to succinylcholine during pregnancy.
authors.affiliation: Department of Anesthesiology, Assaf Harofeh Medical Center, Zerifin, Israel.
authors.forename: Tamar
authors.initials: T
authors.lastname: Miller-Roll
authors.forename: Izabella
authors.initials: I
authors.lastname: Pilcha
authors.forename: Natan
authors.initials: N
authors.lastname: Weksler
authors.forename: Sorina
authors.initials: S
authors.lastname: Negomireanu
authors.forename: Murat
authors.initials: M
authors.lastname: Bahar
mesh_terms: D000328:Adult; D000768:Anesthesia, General / Q000009:adverse effects / Q000379:methods; D001049:Apnea / Q000209:etiology*; D002091:Butyrylcholinesterase / Q000235:genetics* / Q000378:metabolism; D005260:Female; D006801:Humans; D007743:Labor, Obstetric; D009467:Neuromuscular Depolarizing Agents / Q000009:adverse effects / Q000627:therapeutic use; D011247:Pregnancy; D013390:Succinylcholine / Q000008:administration & dosage / Q000009:adverse effects*; D014592:Uterine Hemorrhage / Q000150:complications; D014599:Uterus / Q000601:surgery
chemical_list: D009467:Neuromuscular Depolarizing Agents; D002091:Butyrylcholinesterase; D013390:Succinylcholine