title: Anti-inflammatory activities of fractions from Geranium nepalense and related polyphenols.
abstract: Geranium nepalense Sweet is a common Chinese herbal medicine and has been used as influenza, dysentery, antiphlogistic and analgesic tonic, hemostatic, stomachic, and antidiabetic drugs. The anti-inflammatory effects of G. nepalense on tetradecanoyl phorbol acetate (TPA)-induced mouse ear edema were studied in this work. The results showed that ethyl acetate fraction of the water extract of G. nepalense possessed significant activity at 2.5 g/kg (p < 0.01) with aspirin as a positive control (0.6 g/kg). Six polyphenolic compounds, including three flavonoids, i.e. kaempferol, kaempferol-7-O-β-D-glucopyranoside, and quercetin-7-O-α-rhamnopyranoside, and two tannins, i.e. pyrogallol and gallic acid, and one lignin, i.e. epipinoresinol, were isolated and characterized from ethyl acetate fraction. The isolation of polyphenols provides a clue for beneficial effects of G. nepalense in the demonstrated anti-inflammatory activity.
authors.affiliation: School of Pharmaceutical Sciences, Shandong University, Ji'nan, Shandong, China.
authors.forename: C H
authors.initials: CH
authors.lastname: Lu
authors.forename: Y Y
authors.initials: YY
authors.lastname: Li
authors.forename: L J
authors.initials: LJ
authors.lastname: Li
authors.forename: L Y
authors.initials: LY
authors.lastname: Liang
authors.forename: Y M
authors.initials: YM
authors.lastname: Shen
mesh_terms: D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000302:isolation & purification / Q000494:pharmacology* / Q000627:therapeutic use; D004195:Disease Models, Animal; D004365:Drugs, Chinese Herbal / Q000302:isolation & purification / Q000494:pharmacology* / Q000627:therapeutic use; D004487:Edema / Q000188:drug therapy; D031315:Geranium / Q000737:chemistry*; D051379:Mice; D008815:Mice, Inbred Strains; D015394:Molecular Structure; D059808:Polyphenols / Q000302:isolation & purification / Q000494:pharmacology* / Q000627:therapeutic use; D016896:Treatment Outcome
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D004365:Drugs, Chinese Herbal; D059808:Polyphenols