title: Using noise to determine cardiac restitution with memory.
abstract: Variation in cardiac pacing cycles, as seen, for example, in heart rate variability, has been observed for decades. Contemporarily, various mathematical models have been constructed to investigate the electrical activity of paced cardiac cells. Yet there has not been a study of these cardiac models when there is variation in the pacing cycles such as noise. We present a method that uses the stochasticity of pacing cycles to determine approximate models of the dynamics of cardiac cells, and use these models to detect bifurcations to alternans.
authors.affiliation: Mathematical Biosciences Institute, The Ohio State University, Columbus, Ohio 43210, USA.
authors.forename: Shu
authors.initials: S
authors.lastname: Dai
authors.forename: James P
authors.initials: JP
authors.lastname: Keener
mesh_terms: D000200:Action Potentials / Q000502:physiology*; D000818:Animals; D001683:Biological Clocks / Q000502:physiology*; D003198:Computer Simulation; D006329:Heart Conduction System / Q000502:physiology*; D006801:Humans; D008955:Models, Cardiovascular; D015233:Models, Statistical; D032383:Myocytes, Cardiac / Q000502:physiology*