title: Three new sesquiterpenes from Tithonia diversifolia and their anti-hyperglycemic activity.
abstract: Three new germacrane sesquiterpenes (1), (2), (3), along with eleven known sesquiterpenes, namely, tirotundin-3-O-methyl ether (4), deacetylvguiestin (5), 1β-hydroxydiversifolin-3-O-methyl ether (6), tagitinin C (7), 1β-hydroxytirotundin-3-O-methyl ether (8), 1β-hydroxytirotundin-1,3-O-dimethyl ether (9), tagitinin F-3-O-methyl ether (10), tagitinin F (11), tagitinin A (12), 3β-acetoxy-4α-hydroxyeduesm-11(13)-en-12-oic acid (13) and ilicic acid (14) were isolated from the aerial parts of Tithonia diversifolia. Their structures were established by spectroscopic analysis, while the relative configuration of compound 1 was confirmed by X-ray diffraction analysis. In addition, compounds 1-14 were evaluated in vitro for their anti-hyperglycemic activity by glucose uptake in 3T3-L1 adipocytes. It was found that 10μg/mL 1, 3, 6 and 8 could significantly increase glucose uptake without significant toxic effects.
authors.affiliation: School of Pharmacy, Second Military Medical University, Guohe Road 325#, Shanghai 200433, People's Republic of China.
authors.forename: Guijun
authors.initials: G
authors.lastname: Zhao
authors.forename: Xia
authors.initials: X
authors.lastname: Li
authors.forename: Wansheng
authors.initials: W
authors.lastname: Chen
authors.forename: Zhongxin
authors.initials: Z
authors.lastname: Xi
authors.forename: Lianna
authors.initials: L
authors.lastname: Sun
mesh_terms: D017667:Adipocytes / Q000187:drug effects / Q000378:metabolism; D000818:Animals; D019659:Asteraceae / Q000737:chemistry*; D005947:Glucose / Q000378:metabolism; D007004:Hypoglycemic Agents / Q000737:chemistry* / Q000494:pharmacology*; D012717:Sesquiterpenes / Q000737:chemistry*
chemical_list: D007004:Hypoglycemic Agents; D012717:Sesquiterpenes; D005947:Glucose