title: Prevalence of human leukocyte antigen-B*5701 among HIV-infected children in Thailand and Cambodia: implications for abacavir use.
abstract: Human leukocyte antigen (HLA)-B*5701 allele is associated with abacavir hypersensitivity. Limited data among Asians showed lower rates of HLA-B*5701 compared with Caucasians. In 296 children with HIV in Thailand and Cambodia, the prevalence of HLA-B*5701 was 4.0% (95% confidence interval: 1.6-8.0%) among Thai and 3.4% (95% confidence interval: 0.9-8.5%) among Cambodian children. HLA-B*5701 carriage is not uncommon among Thai and Cambodian children; it is close to the prevalence found in European and higher than the prevalence found in East Asian and African studies.
authors.affiliation: HIV Netherlands Australia Thailand (HIV-NAT) Research Collaboration, The Thai Red Cross AIDS Research Center, Bangkok, Thailand. thanyawee.p@hivnat.or
authors.forename: Thanyawee
authors.initials: T
authors.lastname: Puthanakit
authors.forename: Torsak
authors.initials: T
authors.lastname: Bunupuradah
authors.forename: Pope
authors.initials: P
authors.lastname: Kosalaraksa
authors.forename: Ung
authors.initials: U
authors.lastname: Vibol
authors.forename: Rawiwan
authors.initials: R
authors.lastname: Hansudewechakul
authors.forename: Sasiwimol
authors.initials: S
authors.lastname: Ubolyam
authors.forename: Tulathip
authors.initials: T
authors.lastname: Suwanlerk
authors.forename: Suparat
authors.initials: S
authors.lastname: Kanjanavanit
authors.forename: Chaiwat
authors.initials: C
authors.lastname: Ngampiyaskul
authors.forename: Jurai
authors.initials: J
authors.lastname: Wongsawat
authors.forename: Wicharn
authors.initials: W
authors.lastname: Luesomboon
authors.forename: Saphonn
authors.initials: S
authors.lastname: Vonthanak
authors.forename: Jintanat
authors.initials: J
authors.lastname: Ananworanich
authors.forename: Kiat
authors.initials: K
authors.lastname: Ruxrungtham
mesh_terms: D002160:Cambodia; D002648:Child; D002675:Child, Preschool; D015224:Dideoxynucleosides / Q000009:adverse effects* / Q000627:therapeutic use*; D004342:Drug Hypersensitivity / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D015658:HIV Infections / Q000188:drug therapy*; D015235:HLA-B Antigens / Q000235:genetics*; D006801:Humans; D007223:Infant; D008297:Male; D015995:Prevalence; D013785:Thailand; D000099227:Abacavir
chemical_list: D015224:Dideoxynucleosides; D015235:HLA-B Antigens; D000099227:Abacavir; C484830:HLA-B*57:01 antigen