title: Bladder cancer survival in a former industrial area in Saxony-Anhalt, Germany.
abstract: Long-term follow-ups on bladder cancer patients from highly industrialized areas are rare. Therefore, we present a follow-up of bladder cancer patients from the greater area Lutherstadt Wittenberg, a center of the chemical industry of the former German Democratic Republic. Relapse-free survival times of 213 confirmed bladder cancer cases from the greater area Lutherstadt Wittenberg were collected between 2008 and 2009. Data on lifestyle and occupational exposure to potential carcinogens was recorded by questionnaire. Genotypes of N-acetyltransferase 2 (NAT2), glutathione S-transferase M1 (GSTM1), glutathione S-transferase T1 (GSTT1), rs710521, and rs9642880 were determined by standard methods. Cox models were used to evaluate differences in relapse-free survival. Clear differences in relapse-free survival could be observed for the number of relapses, multilocular tumor growth, and relapses with higher staging or grading than the primary tumor, as well as GSTT1. None of the other investigated polymorphisms showed significant impact on prognosis. This is the first study on two recently detected single-nucleotide polymorphisms (SNPs) showing that these polymorphisms may also contribute to shorter relapse-free times.
authors.affiliation: Department of Urology, Paul Gerhardt Foundation, Lutherstadt Wittenberg, Germany.
authors.forename: Emanuel
authors.initials: E
authors.lastname: Roth
authors.forename: Silvia
authors.initials: S
authors.lastname: Selinski
authors.forename: Christian
authors.initials: C
authors.lastname: Schikowsky
authors.forename: Thilo
authors.initials: T
authors.lastname: Seidel
authors.forename: Frank
authors.initials: F
authors.lastname: Volkert
authors.forename: Meinolf
authors.initials: M
authors.lastname: Blaszkewicz
authors.forename: Jan G
authors.initials: JG
authors.lastname: Hengstler
authors.forename: Klaus
authors.initials: K
authors.lastname: Golka
mesh_terms: D000368:Aged; D001191:Arylamine N-Acetyltransferase / Q000235:genetics; D005260:Female; D005500:Follow-Up Studies; D005819:Genetic Markers; D020022:Genetic Predisposition to Disease; D005858:Germany / Q000453:epidemiology; D005982:Glutathione Transferase / Q000235:genetics; D006801:Humans; D008297:Male; D008875:Middle Aged; D009154:Mutation; D016273:Occupational Exposure; D020641:Polymorphism, Single Nucleotide; D016016:Proportional Hazards Models; D012307:Risk Factors; D001749:Urinary Bladder Neoplasms / Q000453:epidemiology* / Q000235:genetics* / Q000473:pathology
chemical_list: D005819:Genetic Markers; D001191:Arylamine N-Acetyltransferase; D005982:Glutathione Transferase