title: Induction of anti-Plasmodium immunity following subpatent infection with live erythrocytic stages and drug cure.
abstract: An effective malaria vaccine remains an important priority for the millions of people living in malaria endemic regions. Subambitious goals for the development of a vaccine have been set, which aim to achieve a licensed first-generation P. falciparum malaria vaccine with more than 50% protective efficacy against severe disease and death, lasting for at least 1 year by 2015. These goals were set in the context of a subunit vaccine. However, a whole-parasite vaccine might be expected to induce substantially superior protection. Our group has been focusing on low dose blood-stage parasites as a valid vaccine approach, and we present here the relevant methodology for this.
authors.affiliation: Glycomics Institute, Griffith University, Gold Coast, QLD, Australia.
authors.forename: Danielle I
authors.initials: DI
authors.lastname: Stanisic
authors.forename: Michael F
authors.initials: MF
authors.lastname: Good
mesh_terms: D000818:Animals; D000852:Anopheles / Q000469:parasitology; D004912:Erythrocytes / Q000469:parasitology*; D006801:Humans; D017780:Malaria Vaccines / Q000008:administration & dosage / Q000276:immunology*; D016778:Malaria, Falciparum / Q000469:parasitology* / Q000517:prevention & control* / Q000635:transmission; D010963:Plasmodium falciparum / Q000276:immunology*
chemical_list: D017780:Malaria Vaccines