title: Minimally invasive mutagenesis gives rise to a biosynthetic polyketide library.
abstract: Not in the public domain: Site-directed mutagenesis of megasynthases was the key to the generation of a library of polyketides in bacteria. Redox derivatizations are used to change the bioactivity profile of the compounds.
authors.affiliation: Fakultät für Chemie, Chemische Biologie, Technische Universität Dortmund, Otto-Hahn-Strasse 6, 44221 Dortmund, Germany.
authors.forename: Susanna
authors.initials: S
authors.lastname: Kushnir
authors.forename: Uschi
authors.initials: U
authors.lastname: Sundermann
authors.forename: Samir
authors.initials: S
authors.lastname: Yahiaoui
authors.forename: Andreas
authors.initials: A
authors.lastname: Brockmeyer
authors.forename: Petra
authors.initials: P
authors.lastname: Janning
authors.forename: Frank
authors.initials: F
authors.lastname: Schulz
mesh_terms: D009682:Magnetic Resonance Spectroscopy; D016296:Mutagenesis; D010084:Oxidation-Reduction; D048630:Polyketide Synthases / Q000235:genetics* / Q000378:metabolism*; D061065:Polyketides / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D061065:Polyketides; D048630:Polyketide Synthases