title: [Examination of the effectiveness of heart rate control using intravenous β-blocker in 64-slice coronary computed tomography angiography].
abstract: The purpose of this study is to clarify the effectiveness of the use of β-blocker in coronary computed tomography angiography (CCTA). In 1783 patients, heart rate was controlled by propranolol injection to patients with heart rates of 61 bpm or more. As a result, the scan heart rate (58.8±6.5 bpm) decreased significantly compared with the initial heart rate (72.7±9.4 bpm). Prospective gating method was used by 61.9% including 64.3% of the intravenous β-blocker injection group. Moreover, daily use of oral β-blocker had influence on reduction of the scan heart rate (daily use group: 60.1±6.5 bpm vs. unuse group: 58.5±6.3 bpm p<0.01). When we evaluated the image quality of CCTA by the score, the improvement of the score was obviously admitted by 65 bpm or less of the scan heart rate. The ratio of scan heart rate that was controlled by 65 bpm or less was decreased in the initial heart rate groups that were 81 bpm or more. The incidence of adverse reactions by the propranolol injection was few, and these instances only involved slight symptoms. Therefore, heart rate control with the use of β-blocker is useful for the image quality improvement of CCTA. This form of treatment can be safely enforced.
authors.affiliation: Department of Radiology, Hokkaido Social Insurance Hospital.
authors.forename: Takayoshi
authors.initials: T
authors.lastname: Yamaguchi
authors.forename: Daichi
authors.initials: D
authors.lastname: Takahashi
authors.forename: Shingo
authors.initials: S
authors.lastname: Nakagawa
authors.forename: Mari
authors.initials: M
authors.lastname: Morita
authors.forename: Rie
authors.initials: R
authors.lastname: Noda
authors.forename: Yoko
authors.initials: Y
authors.lastname: Nakamura
authors.forename: Keiichi
authors.initials: K
authors.lastname: Igarashi
mesh_terms: D000319:Adrenergic beta-Antagonists / Q000008:administration & dosage / Q000494:pharmacology*; D000368:Aged; D017023:Coronary Angiography / Q000379:methods*; D005260:Female; D006339:Heart Rate / Q000187:drug effects*; D006801:Humans; D007275:Injections, Intravenous; D008297:Male; D011433:Propranolol / Q000008:administration & dosage / Q000494:pharmacology; D014057:Tomography, X-Ray Computed / Q000379:methods*
chemical_list: D000319:Adrenergic beta-Antagonists; D011433:Propranolol