title: Synthesis, characterization and biological screening of sulfonamides derived form 2-phenylethylamine.
abstract: In the present study, a series of N-substituted derivatives of 2-phenylethylamine has been synthesized. The reaction of 2-phenylethylamine (1) with benzene sulfonyl chloride (2) yielded N-(2-phenylethyl) benzenesulfonamide (3), which further on treatment with alkyl/acyl halides (4a-i) in the presence of sodium hydride furnished into N-substituted sulfonamides (5a-i).  These derivatives were characterized by IR, (1)H-NMR and EI-MS and then screened against acetyl cholinesterase (AChE), butyryl cholinesterase (BChE) and lipoxygenase enzyme (LOX)  and were found to be potent inhibitors of butyryl cholinesterase only.
authors.affiliation: Department of Chemistry, Government College University, Lahore, Pakistan. azizryk@yahoo.com
authors.forename: Aziz-ur
authors.initials: AU
authors.lastname: Rehman
authors.forename: Sumbel
authors.initials: S
authors.lastname: Afroz
authors.forename: Muhammad Athar
authors.initials: MA
authors.lastname: Abbasi
authors.forename: Wajeeha
authors.initials: W
authors.lastname: Tanveer
authors.forename: Khalid Mohammed
authors.initials: KM
authors.lastname: Khan
authors.forename: Muhammad
authors.initials: M
authors.lastname: Ashraf
authors.forename: Irshad
authors.initials: I
authors.lastname: Ahmad
authors.forename: Iftikhar
authors.initials: I
authors.lastname: Afzal
authors.forename: Nida
authors.initials: N
authors.lastname: Ambreen
mesh_terms: D000110:Acetylcholinesterase / Q000378:metabolism; D002091:Butyrylcholinesterase / Q000378:metabolism; D002800:Cholinesterase Inhibitors / Q000138:chemical synthesis* / Q000494:pharmacology*; D016859:Lipoxygenase Inhibitors / Q000138:chemical synthesis / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D015394:Molecular Structure; D010627:Phenethylamines / Q000138:chemical synthesis* / Q000494:pharmacology*; D013055:Spectrophotometry, Infrared; D013449:Sulfonamides / Q000138:chemical synthesis* / Q000494:pharmacology*
chemical_list: D002800:Cholinesterase Inhibitors; D016859:Lipoxygenase Inhibitors; D010627:Phenethylamines; D013449:Sulfonamides; C029261:phenethylamine; D000110:Acetylcholinesterase; D002091:Butyrylcholinesterase