title: Reengineered epipodophyllotoxin.
abstract: A variant structural skeleton of epipodophyllotoxin was synthesized and found to rival the natural cyclolignan in antiproliferative and microtubule destabilizing properties. This discovery leads to a new structural class of tubulin targeting agents.
authors.affiliation: Department of Chemistry, New Mexico Institute of Mining and Technology, Socorro, New Mexico 87801, USA. imagedov@nmt.edu
authors.forename: Igor V
authors.initials: IV
authors.lastname: Magedov
authors.forename: Nikolai M
authors.initials: NM
authors.lastname: Evdokimov
authors.forename: Menuka
authors.initials: M
authors.lastname: Karki
authors.forename: Amanda S
authors.initials: AS
authors.lastname: Peretti
authors.forename: Dustin T
authors.initials: DT
authors.lastname: Lima
authors.forename: Liliya V
authors.initials: LV
authors.lastname: Frolova
authors.forename: Mary R
authors.initials: MR
authors.lastname: Reisenauer
authors.forename: Anntherese E
authors.initials: AE
authors.lastname: Romero
authors.forename: Paul
authors.initials: P
authors.lastname: Tongwa
authors.forename: Alexandr
authors.initials: A
authors.lastname: Fonari
authors.forename: Jeff
authors.initials: J
authors.lastname: Altig
authors.forename: Snezna
authors.initials: S
authors.lastname: Rogelj
authors.forename: Mikhail Yu
authors.initials: MY
authors.lastname: Antipin
authors.forename: Charles B
authors.initials: CB
authors.lastname: Shuster
authors.forename: Alexander
authors.initials: A
authors.lastname: Kornienko
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D017209:Apoptosis / Q000187:drug effects; D049109:Cell Proliferation / Q000187:drug effects; D018360:Crystallography, X-Ray; D004354:Drug Screening Assays, Antitumor; D006367:HeLa Cells; D006801:Humans; D019169:Jurkat Cells; D061986:MCF-7 Cells; D008958:Models, Molecular; D015394:Molecular Structure; D011034:Podophyllotoxin / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D011034:Podophyllotoxin