title: Synthesis and anticoagulation activities of polymer/functional graphene oxide nanocomposites via Reverse Atom Transfer Radical Polymerization (RATRP).
abstract: The anticoagulation properties of biomaterials are crucial for biomedical applications, especially for blood-contacting materials. In this work, a range of functional graphene oxide based on the biomimetic monomer 2-(methacryloyloxy) ethyl phosphorylcholine (GO-g-pMPC) were synthesized by RATRP in alcoholic media using peroxide groups as initiator, and then filled into the polyurethane matrix to obtain the polyurethane (PU)/functional graphene oxide nanocomposite films (PU/GO-g-pMPC). The tensile strength and elongation and morphology of the PU/GO-g-pMPC were characterized by mechanical properties test, Transmission electron microscope (TEM), respectively. The results showed that a small amount of graphene oxide can improve the mechanical properties of PU. The blood compatibility of the PU substrates was evaluated by protein adsorption tests and platelet adhesion tests in vitro. It was found that all the PU/GO-g-pMPC showed improved resistance to nonspecific protein adsorption and platelet adhesion.
authors.affiliation: Jiangsu Key Laboratory of Biofunctional Materials, College of Chemistry and Materials Science, Nanjing Normal University, Nanjing 210097, China.
authors.forename: Su-xing
authors.initials: SX
authors.lastname: Jin
authors.forename: Ning-lin
authors.initials: NL
authors.lastname: Zhou
authors.forename: Dong
authors.initials: D
authors.lastname: Xu
authors.forename: Yue
authors.initials: Y
authors.lastname: Wu
authors.forename: Yi-da
authors.initials: YD
authors.lastname: Tang
authors.forename: Chun-yan
authors.initials: CY
authors.lastname: Lu
authors.forename: Jun
authors.initials: J
authors.lastname: Zhang
authors.forename: Jian
authors.initials: J
authors.lastname: Shen
mesh_terms: D000327:Adsorption; D000925:Anticoagulants / Q000138:chemical synthesis* / Q000494:pharmacology*; D040761:Biomimetic Materials; D006108:Graphite / Q000737:chemistry* / Q000494:pharmacology*; D006461:Hemolysis / Q000187:drug effects; D006801:Humans; D007700:Kinetics; D055595:Mechanical Phenomena; D008855:Microscopy, Electron, Scanning; D046529:Microscopy, Electron, Transmission; D049329:Nanostructures / Q000737:chemistry*; D010545:Peroxides / Q000737:chemistry; D010973:Platelet Adhesiveness / Q000187:drug effects; D058105:Polymerization; D011140:Polyurethanes / Q000737:chemistry; D013718:Tensile Strength
chemical_list: D000925:Anticoagulants; D010545:Peroxides; D011140:Polyurethanes; D006108:Graphite