title: Interplay between vitamin D and the drug metabolizing enzyme CYP3A4.
abstract: Cytochrome P450 3A4 (CYP3A4) is a multifunctional enzyme involved in both xenobiotic and endobiotic metabolism. This review focuses on two aspects: regulation of CYP3A4 expression by vitamin D and metabolism of vitamin D by CYP3A4. Enterohepatic circulation of vitamin D metabolites and their conjugates will be also discussed. The interplay between vitamin D and CYP3A4 provides new insights into our understanding of how enzyme induction can contribute to vitamin D deficiency. This article is part of a Special Issue entitled 'Vitamin D Workshop'.
authors.affiliation: Department of Pharmaceutics, University of Washington, Seattle, WA 98195,, United States.
authors.forename: Zhican
authors.initials: Z
authors.lastname: Wang
authors.forename: Erin G
authors.initials: EG
authors.lastname: Schuetz
authors.forename: Yang
authors.initials: Y
authors.lastname: Xu
authors.forename: Kenneth E
authors.initials: KE
authors.lastname: Thummel
mesh_terms: D000818:Animals; D001711:Biotransformation; D051544:Cytochrome P-450 CYP3A / Q000378:metabolism*; D004764:Enterohepatic Circulation; D004790:Enzyme Induction / Q000502:physiology; D006801:Humans; D008954:Models, Biological; D014807:Vitamin D / Q000493:pharmacokinetics*; D014808:Vitamin D Deficiency / Q000209:etiology
chemical_list: D014807:Vitamin D; D051544:Cytochrome P-450 CYP3A; C510163:CYP3A4 protein, human