title: [Effect of mu- and kappa-opioid receptor antagonists on aggressiveness of male mice with repeated experience of aggression].
abstract: Mu and kappa opioid receptors often show opposite actions in the regulation ofphysiological functions and behaviors including aggressive behavior. In the present study, effects ofmu antagonist CTAP (1 and 2 mg/kg, sc) and kappa antagonist nor-BNI (0.5 mg/kg, sc) on the manifestation of aggressive behavior of C57BL/6J male mice with a short (3 days) and a long (20 days) experience of victories in daily intermale confrontations were investigated. It was shown that the mice with a short experience of aggression are tolerant to blockade of both mu and kappa opioid receptors. In the mice with a long experience of aggression, CTAP increased latency of aggression in dose-dependent manner, but did not change the duration of attacks. Nor-BNI had no influence on the behavior of the male mice with a long experience of aggression in the intermale confrontation. The possible changes in opioid receptor sensitivity in C57BL/6J male mice under the influence ofa long experience of aggression are discussed.
authors.forename: N P
authors.initials: NP
authors.lastname: Bondar'
mesh_terms: D000374:Aggression / Q000187:drug effects* / Q000502:physiology; D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects* / Q000502:physiology; D004305:Dose-Response Relationship, Drug; D007279:Injections, Subcutaneous; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D009271:Naltrexone / Q000008:administration & dosage / Q000031:analogs & derivatives*; D009292:Narcotic Antagonists / Q000008:administration & dosage*; D010446:Peptide Fragments / Q000008:administration & dosage*; D017473:Receptors, Opioid, kappa / Q000037:antagonists & inhibitors / Q000378:metabolism; D017450:Receptors, Opioid, mu / Q000037:antagonists & inhibitors / Q000378:metabolism; D013004:Somatostatin / Q000008:administration & dosage*
chemical_list: C529311:CTAP octapeptide; D009292:Narcotic Antagonists; D010446:Peptide Fragments; D017473:Receptors, Opioid, kappa; D017450:Receptors, Opioid, mu; C051844:norbinaltorphimine; D013004:Somatostatin; D009271:Naltrexone