title: [Research progress of magnesium and its alloys as orthopedic implant biomaterial].
abstract: Magnesium based implants have the characteristics of bio-degradability, osteoconductive, and, regulatory strength. After the tissue has healed sufficiently, the burden of a second surgical procedure can be avoided. However, the degradation speed is so fast as to limit its clinical application. Hence, it is crucial for the biomedical magnesium alloys to be able to change their biodegradation behavior and speed. This paper reviews the degradability, biological activity and biocompatibility of magnesium and its alloys as orthopedic biomaterial in vitro and vivo to explore the possible way to modify the characteristics of its degradability, for the purpose of controllable degradation speed.
authors.affiliation: Department of Orthopedic Surgery, the First Affiliated Hospital of Harbin Medical University, Harbin 150001, China.
authors.forename: Fengjiao
authors.initials: F
authors.lastname: Wang
authors.forename: Jinpeng
authors.initials: J
authors.lastname: Zhuang
authors.forename: Lei
authors.initials: L
authors.lastname: Zhou
authors.forename: Jinglong
authors.initials: J
authors.lastname: Yan
mesh_terms: D020341:Absorbable Implants; D000497:Alloys / Q000737:chemistry*; D000818:Animals; D001672:Biocompatible Materials / Q000138:chemical synthesis*; D001860:Bone Plates; D001863:Bone Screws; D018786:Bone Substitutes / Q000737:chemistry; D006801:Humans; D008274:Magnesium / Q000737:chemistry*
chemical_list: D000497:Alloys; D001672:Biocompatible Materials; D018786:Bone Substitutes; D008274:Magnesium