title: NXCL-4950, a novel composite applicable to peripheral skin, is capable of increasing skin temperature by enhancing capillary circulation.
abstract: BACKGROUND
  Rapid skin warming and prompt correct medical treatment lead to dramatic improvement in patients with peripheral capillary-related damage, such as injuries, Raynaud disease and frostbite.
  
  
  OBJECTIVE
  To characterize a novel composite, NXCL-4950, for use in a cosmetic lotion.
  
  
  METHODS
  The effects of NXCL-4950 on enhancing skin blood flow, skin temperature warming, and expansion of peripheral blood vessels and scalp microvessels were investigated.
  
  
  RESULTS
  Monitoring by laser Doppler perfusion imaging and thermal imaging showed that application of NXCL-4950 to the hands increased skin blood flow and temperature relative to the control (or placebo) group. For the 20 participants with a high Raynaud Condition Score, application of NXCL-4950 to the skin resulted in a mean increase of 215.53% in microvessel diameter and mean increase of 164.96% in the speed of blood flow. When NXCL-4950 was applied to the scalp, the microvessels around the hair roots were clearly visible after 20 min.
  
  
  CONCLUSIONS
  NXCL-4950 is a potential candidate for enhancing peripheral skin temperature, and might be useful in the treatment of capillary-related disorders.
authors.affiliation: Department of Biomedical Laboratory Science, Gimcheon University, Gimcheon, Korea. jenokin@nate.com
authors.forename: D-C
authors.initials: DC
authors.lastname: Kim
authors.forename: C-E
authors.initials: CE
authors.lastname: Lee
mesh_terms: D000287:Administration, Topical; D000328:Adult; D045424:Complex Mixtures / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D017078:Laser-Doppler Flowmetry; D008297:Male; D055806:Microvessels / Q000187:drug effects; D016491:Peripheral Vascular Diseases / Q000188:drug therapy*; D010936:Plant Extracts / Q000627:therapeutic use*; D012039:Regional Blood Flow / Q000187:drug effects*; D012535:Scalp / Q000187:drug effects; D012867:Skin / Q000098:blood supply; D012871:Skin Diseases / Q000188:drug therapy*; D012881:Skin Temperature / Q000187:drug effects*; D014665:Vasodilator Agents / Q000627:therapeutic use*; D055815:Young Adult
chemical_list: D045424:Complex Mixtures; C583429:NXCL-4950; D010936:Plant Extracts; D014665:Vasodilator Agents