title: Expression  profiling based on coexpressed modules in obese prepubertal children.
abstract: The  aim of this study was to identify related genes and the underlying molecular  mechanisms in obese patients who show a series of clinical and metabolic  abnormalities known as metabolic syndrome. We identified expression profiles  through a coexpression network. In addition, a similarity matrix and expression  modules were constructed based on domain and pathway enrichment analysis. The  genes in module 1 were mainly involved in the metabolism of xenobiotics by  cytochrome P450, aldosterone-regulated sodium reabsorption, and focal adhesion  owing to the presence of aldo/ketoreductase, basic helix-loop-helix, von  Willebrand factor, Frizzled-related domain, and other domains. The genes in  module 3 may be involved in cell cycle (hsa04110) and DNA replication (hsa03030)  pathways through mini-chromosome maintenance, serine/threonine protein kinase,  the protein kinase domain, and other domains. We analyzed the published  molecular mechanisms of obesity and found many genes and pathways that have not  been given enough attention and require further confirmation.
authors.affiliation: Department of Child Health Care, Shanghai Children's Hospital, Shanghai Jiao Tong University, Shanghai, China.
authors.forename: J F
authors.initials: JF
authors.lastname: Zhang
authors.forename: G Y
authors.initials: GY
authors.lastname: Yao
authors.forename: Y H
authors.initials: YH
authors.lastname: Wu
mesh_terms: D002648:Child; D016000:Cluster Analysis; D020869:Gene Expression Profiling; D005786:Gene Expression Regulation; D053263:Gene Regulatory Networks / Q000235:genetics*; D006801:Humans; D009765:Obesity / Q000235:genetics*; D011627:Puberty / Q000235:genetics*; D015398:Signal Transduction / Q000235:genetics