title: Coxsackievirus and adenovirus receptor promotes antitumor activity of             oncolytic adenovirus H101 in esophageal cancer.
abstract: Esophageal cancer is an intractable disease due to late diagnosis, high             incidence of post-surgical locoregional recurrence and frequent distant metastasis.             Oncolytic adenovirus (Ad) vectors are a promising method for cancer treatment.             The H101 virus is a recombinant Ad which has replication-selective properties             and replicates only in tumor cells. The coxsackievirus and adenovirus receptor             (CAR) is considered a surrogate marker that monitors the outcome of Ad-mediated             gene therapy. Accumulating evidence indicates that CAR expression levels are lower             in various types of tumors such as ovarian, lung, breast and bladder when compared             to their normal counterparts. In this study, we reported that trichostatin A (TSA)             induced the expression of CAR in esophageal squamous cell carcinoma (ESCC) cell             lines through the MAPK/ERK1/2 signaling pathway. The expression levels of CAR             were positively related with the antitumor activity of H101. Our results suggest             that TSA increases the antitumor activity of the oncolytic adenovirus H101 through             the MAPK/ERK pathway.
authors.affiliation: Department of Pathophysiology, School of Basic Medical Sciences,                     Zhengzhou University, Zhengzhou 450001, P.R. China.
authors.forename: Junfen
authors.initials: J
authors.lastname: Ma
authors.forename: Jimin
authors.initials: J
authors.lastname: Zhao
authors.forename: Jing
authors.initials: J
authors.lastname: Lu
authors.forename: Yanan
authors.initials: Y
authors.lastname: Jiang
authors.forename: Hongyan
authors.initials: H
authors.lastname: Yang
authors.forename: Pei
authors.initials: P
authors.lastname: Li
authors.forename: Mingyao
authors.initials: M
authors.lastname: Zhao
authors.forename: Kangdong
authors.initials: K
authors.lastname: Liu
authors.forename: Ziming
authors.initials: Z
authors.lastname: Dong
mesh_terms: D000256:Adenoviridae / Q000502:physiology*; D002294:Carcinoma, Squamous Cell; D002470:Cell Survival / Q000187:drug effects; D062727:Coxsackie and Adenovirus Receptor-Like Membrane Protein / Q000235:genetics / Q000378:metabolism*; D004938:Esophageal Neoplasms; D015870:Gene Expression / Q000187:drug effects; D006367:HeLa Cells; D056572:Histone Deacetylase Inhibitors / Q000494:pharmacology; D006801:Humans; D006877:Hydroxamic Acids / Q000494:pharmacology; D020935:MAP Kinase Signaling System; D050504:Oncolytic Viruses / Q000502:physiology*; D015533:Transcriptional Activation / Q000187:drug effects; D053586:Virus Internalization; D014779:Virus Replication
chemical_list: C568771:CLMP protein, human; D062727:Coxsackie and Adenovirus Receptor-Like Membrane Protein; D056572:Histone Deacetylase Inhibitors; D006877:Hydroxamic Acids; C012589:trichostatin A