title: Systemic inflammation associated with severe intestinal injury in extremely low gestational age newborns.
abstract: To define the role of systemic inflammation in infants with intestinal perforation (IP) and necrotizing enterocolitis (NEC), we measured 25 blood protein concentrations on days 1, 7 and 14 in 939 infants born before 28 weeks' gestation. On days 7 and 14, infants with NEC had elevated levels of C-reactive protein (CRP), serum amyloid A (SAA), IL-6 and IL-8. Infants with IP had elevated levels of CRP and insulin growth factor binding protein-1 on day 7 and elevated CRP, SAA, TNF-receptor-2 and matrix metalloproteinase-9 levels on day 14. A better understanding of systemic inflammation might help prevent and treat these disorders.
authors.affiliation: Department of Neonatology, Beth Israel Deaconess Medical Center, Boston, MA, USA. cmartin1@bidmc.harvard.edu
authors.forename: Camilia R
authors.initials: CR
authors.lastname: Martin
authors.forename: Melissa
authors.initials: M
authors.lastname: Bellomy
authors.forename: Elizabeth N
authors.initials: EN
authors.lastname: Allred
authors.forename: Raina N
authors.initials: RN
authors.lastname: Fichorova
authors.forename: Alan
authors.initials: A
authors.lastname: Leviton
mesh_terms: D015415:Biomarkers / Q000097:blood; D001798:Blood Proteins / Q000378:metabolism; D003092:Colitis / Q000097:blood / Q000150:complications / Q000473:pathology*; D005260:Female; D005865:Gestational Age; D006801:Humans; D062071:Infant, Extremely Premature; D007231:Infant, Newborn; D007235:Infant, Premature, Diseases / Q000097:blood / Q000473:pathology*; D007416:Intestinal Perforation / Q000097:blood / Q000150:complications / Q000473:pathology*; D009336:Necrosis; D010920:Placenta / Q000382:microbiology / Q000473:pathology; D011247:Pregnancy; D047928:Premature Birth; D018805:Sepsis / Q000097:blood / Q000150:complications / Q000473:pathology*
chemical_list: D015415:Biomarkers; D001798:Blood Proteins