title: In vitro antioxidant activity potential of lantadene A, a pentacyclic triterpenoid of Lantana plants.
abstract: Lantadenes are pentacyclic triterpenoids present in the leaves of the plant Lantana camara. In the present study, in vitro antioxidant activity and free radical scavenging capacity of lantadene A was evaluated using established in vitro models such as ferric reducing antioxidant power (FRAP), 2,2-diphenyl-1-picryl-hydrazyl (DPPH•), hydroxyl radical (OH•), nitric oxide radical (NO•), superoxide anion scavenging activities and ferrous ion chelating assay. Interestingly, lantadene A showed considerable in vitro antioxidant, free radical scavenging capacity activities in a dose dependant manner when compared with the standard antioxidant in nitric oxide scavenging, superoxide anion radical scavenging and ferrous ion chelating assay. These findings show that the lantadene A possesses antioxidant activity with different mechanism of actions towards the different free radicals tested. Since lantadene A is a very popular drug in modern medicine, it is a promising candidate for use as an antioxidant and hepatoprotective agent.
authors.affiliation: Institute for Research in Molecular Medicine, Universiti Sains Malaysia, Pulau Pinang 11800, Malaysia. gracelynn87@gmail.com
authors.forename: Chong
authors.initials: C
authors.lastname: Grace-Lynn
authors.forename: Ibrahim
authors.initials: I
authors.lastname: Darah
authors.forename: Yeng
authors.initials: Y
authors.lastname: Chen
authors.forename: Lachimanan Yoga
authors.initials: LY
authors.lastname: Latha
authors.forename: Subramanion L
authors.initials: SL
authors.lastname: Jothy
authors.forename: Sreenivasan
authors.initials: S
authors.lastname: Sasidharan
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000737:chemistry / Q000494:pharmacology* / Q000633:toxicity; D001713:Biphenyl Compounds / Q000737:chemistry; D002460:Cell Line; D002522:Chlorocebus aethiops; D016166:Free Radical Scavengers / Q000737:chemistry / Q000494:pharmacology / Q000633:toxicity; D017665:Hydroxyl Radical / Q000378:metabolism; D032410:Lantana / Q000737:chemistry*; D009569:Nitric Oxide / Q000378:metabolism; D009828:Oleanolic Acid / Q000031:analogs & derivatives* / Q000737:chemistry / Q000494:pharmacology / Q000633:toxicity; D010084:Oxidation-Reduction; D010851:Picrates / Q000737:chemistry; D018515:Plant Leaves / Q000737:chemistry; D013481:Superoxides / Q000378:metabolism; D014315:Triterpenes / Q000737:chemistry / Q000494:pharmacology / Q000633:toxicity; D014709:Vero Cells
chemical_list: D000975:Antioxidants; D001713:Biphenyl Compounds; D016166:Free Radical Scavengers; D010851:Picrates; D014315:Triterpenes; D013481:Superoxides; D009569:Nitric Oxide; D017665:Hydroxyl Radical; D009828:Oleanolic Acid; C019074:rehmannic acid; C004931:1,1-diphenyl-2-picrylhydrazyl