title: Selenium/Tellurium-Containing Hyperbranched Polymers: Effect of Molecular Weight and Degree of Branching on Glutathione Peroxidase-Like Activity.
abstract: A series of novel hyperbranched polyselenides and polytellurides with multiple catalytic sites at the branching units has been synthesized via the polycondensation of A2 + B3 monomers. The GPx-like activities of these polymer mimics were assessed and it was found that the polytellurides showed higher GPx-like activities than the corresponding polyselenides. Interestingly, the polymers with higher molecular weights and degree of branching (DB) showed higher GPx-like activities than the analogous lower molecular weight polymer. The enhancement in the catalytical activity of the hyperbranched polymers with increasing molecular weight affirmed the importance of the incorporation of multiple catalytic groups in the macromolecule which increases the local concentration of catalytic sites.
authors.affiliation: Molecular Design and Synthesis, Department of Chemistry, University of Leuven, Celestijnenlaan, 200F, 3001 Leuven (Heverlee), Belgium.
authors.forename: Joice
authors.initials: J
authors.lastname: Thomas
authors.affiliation: Molecular Design and Synthesis, Department of Chemistry, University of Leuven, Celestijnenlaan, 200F, 3001 Leuven (Heverlee), Belgium.|State Key Laboratory of Supramolecular Structure and Materials, College of Chemistry, Jilin University, 2699 Qianjin Road, Changchun 130012, P. R. China.
authors.forename: Zeyuan
authors.initials: Z
authors.lastname: Dong
authors.affiliation: Molecular Design and Synthesis, Department of Chemistry, University of Leuven, Celestijnenlaan, 200F, 3001 Leuven (Heverlee), Belgium.
authors.forename: Wim
authors.initials: W
authors.lastname: Dehaen
authors.affiliation: Molecular Design and Synthesis, Department of Chemistry, University of Leuven, Celestijnenlaan, 200F, 3001 Leuven (Heverlee), Belgium. Mario.Smet@chem.kuleuven.be.
authors.forename: Mario
authors.initials: M
authors.lastname: Smet
mesh_terms: D040761:Biomimetic Materials / Q000138:chemical synthesis / Q000737:chemistry*; D002384:Catalysis; D020134:Catalytic Domain; D005979:Glutathione Peroxidase / Q000737:chemistry; D008970:Molecular Weight; D016566:Organoselenium Compounds / Q000138:chemical synthesis / Q000737:chemistry*; D011108:Polymers / Q000138:chemical synthesis / Q000737:chemistry*; D012643:Selenium / Q000737:chemistry*; D013691:Tellurium / Q000737:chemistry*
chemical_list: D016566:Organoselenium Compounds; D011108:Polymers; D005979:Glutathione Peroxidase; D012643:Selenium; D013691:Tellurium