title: Concentrations of IL-15, IL-18, IFN-γ and activity of CD4+, CD8+and NK cells at admission in children with viral bronchiolitis.
abstract: The pathogenesis of viral bronchiolitis is poorly understood. The aim of this study was to analyze interleukin (IL)-15, IL-18 and interferon (IFN)-γ concentrations and the activity of NK cells and CD4+and CD8+lymphocytes in 23 children not older than 30 months of age with acute viral bronchiolitis using blood samples drawn within the first 24 h of their hospital admission, in comparison to a healthy group. In children with bronchiolitis, the mean concentrations of IL-15, IL-18 and IFN-γ were 9.39±11.55, 884.03±645.44 and 17.92±27.14 pg/ml, respectively, and were significantly higher than those in the control group [2.34±0.61 pg/ml (p<0.05), 248.69±98.73 pg/ml (p<0.001) and 2.75±1.72 pg/ml (p<0.005), respectively]. In the bronchiolitis group, mean z-scores were -1.15±1.9 for CD4+cells and -0.9±1.23 for CD8+cells; these scores were significantly lower than those of the general Polish population (p<0.001 and <0.01, respectively). However, the mean z-score of the ratio of CD4+/CD8+and the NK cell count in children with bronchiolitis did not differ significantly from those of the controls. In conclusion, cytokines such as IL-15, IL-18 and IFN-γ play a role in the pathogenesis of bronchiolitis in children.
authors.affiliation: Departments of Pediatrics, Hematology and Oncology.
authors.forename: Elżbieta
authors.initials: E
authors.lastname: Grześk
authors.affiliation: Departments of Pediatrics, Hematology and Oncology.
authors.forename: Sylwia
authors.initials: S
authors.lastname: Kołtan
authors.affiliation: Departments of Pediatrics, Hematology and Oncology.
authors.forename: Robert
authors.initials: R
authors.lastname: Dębski
authors.affiliation: Departments of Pediatrics, Hematology and Oncology.
authors.forename: Mariusz
authors.initials: M
authors.lastname: Wysocki
authors.affiliation: Laboratory Medicine, Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Torun, 85-094 Bydgoszcz, Poland.
authors.forename: Marzena
authors.initials: M
authors.lastname: Gruszka
authors.affiliation: Departments of Pediatrics, Hematology and Oncology.
authors.forename: Małgorzata
authors.initials: M
authors.lastname: Kubicka
authors.affiliation: Departments of Pediatrics, Hematology and Oncology.
authors.forename: Andrzej
authors.initials: A
authors.lastname: Kołtan
authors.affiliation: Pharmacology and Therapeutics, and.
authors.forename: Grzegorz
authors.initials: G
authors.lastname: Grześk
authors.affiliation: Laboratory Medicine, Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Torun, 85-094 Bydgoszcz, Poland.
authors.forename: Sławomir
authors.initials: S
authors.lastname: Manysiak
authors.affiliation: Laboratory Medicine, Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Torun, 85-094 Bydgoszcz, Poland.
authors.forename: Grażyna
authors.initials: G
authors.lastname: Odrowąż-Sypniewska