title: Prominent megakaryocytic dysplasia after regression of transient abnormal myelopoiesis associated with GATA-1 mutation.
abstract: About a quarter of children with Down syndrome and transient abnormal myelopoiesis (TAM) progress to acute megakaryoblastic leukemia (AMKL). We describe isolated dysmegakaryopoiesis despite complete resolution of TAM in an 18-month-old girl, who developed AMKL 6 months later.
authors.affiliation: Department of Pediatric Hemato-Oncology, Royal Marsden Hospital, Surrey, UK. aparan@doctors.org.uk
authors.forename: Parameswaran
authors.initials: P
authors.lastname: Anoop
authors.forename: Ayad
authors.initials: A
authors.lastname: Atra
mesh_terms: D019070:Cell Lineage; D002467:Cell Nucleus / Q000648:ultrastructure; D002999:Clone Cells; D018450:Disease Progression; D004314:Down Syndrome / Q000097:blood* / Q000150:complications* / Q000209:etiology / Q000235:genetics; D005260:Female; D050982:GATA1 Transcription Factor / Q000235:genetics*; D006801:Humans; D007231:Infant, Newborn; D007947:Leukemia, Megakaryoblastic, Acute / Q000209:etiology* / Q000235:genetics / Q000473:pathology; D007955:Leukemoid Reaction / Q000209:etiology* / Q000235:genetics; D008533:Megakaryocytes / Q000473:pathology; D011289:Preleukemia / Q000209:etiology* / Q000473:pathology; D013921:Thrombocytopenia / Q000209:etiology*; D034061:Thrombopoiesis; D014617:Vacuoles / Q000648:ultrastructure
chemical_list: D050982:GATA1 Transcription Factor; C494688:GATA1 protein, human