title: Plasma rich in growth factors in human extraction sockets: a radiographic and histomorphometric study on early bone deposition.
abstract: OBJECTIVE
  To determine whether and to what extent the additional application of plasma rich in growth factors (PRGF) to an extraction socket may influence the early bone deposition, as assessed by micro-computed tomography (micro-CT) scan as well as histomorphometric markers.
  
  
  METHODS
  Twenty-eight patients (age range: 34-74 years) contributing 36 extraction sockets were included in the study. Sockets were either treated with PRGF (PRGF group; 18 sites in 11 patients) or left to spontaneous healing (control group; 18 sites in 17 patients). Radiographic and histomorphometric analysis was performed on bone cores trephined from each healing socket after 4-6 (T1) or 7-10 (T2) weeks of healing.
  
  
  RESULTS
  Patients treated with PRGF application showed (i) similar bone volume and tissue mineral content, (ii) a trend, although not statistically significant, toward a greater number of CD68+ cells (at T1 and T2) and vVW+ cells (at T1), and (iii) a similar OCN staining score throughout the study, when compared with control group.
  
  
  CONCLUSIONS
  Plasma rich in growth factors-treated group did not show any enhancement in early (4 and 8 weeks) bone deposition compared with control group.
authors.affiliation: Research Centre for the Study of Periodontal and Peri-Implant Diseases, University of Ferrara, Ferrara, Italy.
authors.forename: Roberto
authors.initials: R
authors.lastname: Farina
authors.forename: Eriberto
authors.initials: E
authors.lastname: Bressan
authors.forename: Andrei
authors.initials: A
authors.lastname: Taut
authors.forename: Alessandro
authors.initials: A
authors.lastname: Cucchi
authors.forename: Leonardo
authors.initials: L
authors.lastname: Trombelli
mesh_terms: D000328:Adult; D000368:Aged; D015703:Antigens, CD / Q000378:metabolism; D015214:Antigens, Differentiation, Myelomonocytic / Q000378:metabolism; D001861:Bone Regeneration / Q000187:drug effects*; D005260:Female; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins / Q000494:pharmacology*; D008297:Male; D008875:Middle Aged; D015675:Osteocalcin / Q000378:metabolism; D010949:Plasma / Q000737:chemistry*; D014081:Tooth Extraction; D020390:Tooth Socket / Q000000981:diagnostic imaging / Q000187:drug effects*; D014945:Wound Healing / Q000187:drug effects*; D055114:X-Ray Microtomography; D014841:von Willebrand Factor / Q000378:metabolism; D000097382:CD68 Molecule
chemical_list: D015703:Antigens, CD; D015214:Antigens, Differentiation, Myelomonocytic; D036341:Intercellular Signaling Peptides and Proteins; D015675:Osteocalcin; D014841:von Willebrand Factor; C067980:CD68 antigen, human; D000097382:CD68 Molecule; C029417:Von Willebrand antigen