title: Peritrabecular clefting in fibrous dysplasia of the jaws: an important histopathologic feature for differentiating fibrous dysplasia from central ossifying fibroma.
abstract: OBJECTIVE
  The aim of this multicenter study was to perform a histomorphometric analysis of peritrabecular clefting in fibrous dysplasia (FD) in an attempt to obtain data that could be useful for distinguishing between FD and ossifying fibroma (OF).
  
  
  METHODS
  A clinicopathologic analysis was performed in 68 patients diagnosed with FD and 37 patients diagnosed with OF. Histologic sections were scanned using an Aperio ScanScope CS. A histomorphometric analysis was performed with the aid of an image analyzer (UTHSCSA Image Tool 3.0 version) on 37 randomly selected samples of FD, and the results were compared with the 37 OF specimens.
  
  
  RESULTS
  The presence of peritrabecular clefting was observed in 32 (86.5%) cases of FD, whereas no case of OF presented peritrabecular clefting.
  
  
  CONCLUSIONS
  Peritrabecular clefting may be a hallmark of the lesions in patients with FD, and it may be a valuable microscopic feature for distinguishing it from OF.
authors.affiliation: Department of Oral Diagnosis, University of Campinas, Piracicaba Dental School, Piracicaba, São Paulo, Brasil.
authors.forename: Ana Carolina
authors.initials: AC
authors.lastname: Prado Ribeiro
authors.forename: Roman
authors.initials: R
authors.lastname: Carlos
authors.forename: Paul M
authors.initials: PM
authors.lastname: Speight
authors.forename: Keith D
authors.initials: KD
authors.lastname: Hunter
authors.forename: Alan Roger
authors.initials: AR
authors.lastname: Santos-Silva
authors.forename: Oslei Paes
authors.initials: OP
authors.lastname: de Almeida
authors.forename: Pablo Agustin
authors.initials: PA
authors.lastname: Vargas
mesh_terms: D000328:Adult; D054893:Cone-Beam Computed Tomography; D003937:Diagnosis, Differential; D005260:Female; D018214:Fibroma, Ossifying / Q000000981:diagnostic imaging / Q000473:pathology*; D005357:Fibrous Dysplasia of Bone / Q000000981:diagnostic imaging / Q000473:pathology*; D006801:Humans; D007573:Jaw Neoplasms / Q000000981:diagnostic imaging / Q000473:pathology*; D008297:Male; D011862:Radiography, Panoramic; D012189:Retrospective Studies