title: Cross-reactive antibody response to the pandemic A (H1N1) 2009 influenza virus induced by vaccination with a seasonal trivalent influenza vaccine: a longitudinal study of three influenza seasons in Japan.
abstract: The cross-reactivity of antibody to the swine-origin pandemic influenza A (H1N1) 2009 virus induced by vaccination with a seasonal trivalent influenza vaccine was studied. Paired sera from a cohort of adult volunteers vaccinated with a trivalent seasonal influenza vaccine every year from 2006 to 2008 were collected each year and tested by hemagglutination inhibition (HI) for antibody against the pandemic influenza A (H1N1) 2009 virus. There was little increase in the geometric mean titer overall; a slight increase was detected in the sera obtained in the 2007-2008 season but not in the other two seasons. The proportion of individuals with HI antibody titers ≥ 1:40 did not change significantly from year to year. These results indicate that cross-reactivity of the antibodies induced by a trivalent seasonal vaccine to the pandemic influenza A (H1N1) 2009 virus is marginal.
authors.affiliation: Headquarters, Chemo-Sero-Therapeutic Research Institute Kaketsuken, Kumamoto 860-8568, Japan. uno-shi@kaketsuken.or.jp
authors.forename: Shingo
authors.initials: S
authors.lastname: Uno
authors.forename: Kazuhiko
authors.initials: K
authors.lastname: Kimachi
authors.forename: Fujio
authors.initials: F
authors.lastname: Matsuo
authors.forename: Keiichiro
authors.initials: K
authors.lastname: Miyazaki
authors.forename: Ayano
authors.initials: A
authors.lastname: Oohama
authors.forename: Junko
authors.initials: J
authors.lastname: Kei
authors.forename: Tomohiro
authors.initials: T
authors.lastname: Nishimura
authors.forename: Koichi
authors.initials: K
authors.lastname: Odoh
authors.forename: Yoichiro
authors.initials: Y
authors.lastname: Kino
mesh_terms: D000328:Adult; D000914:Antibodies, Viral / Q000097:blood*; D003429:Cross Reactions; D005260:Female; D006385:Hemagglutination Inhibition Tests; D006801:Humans; D053118:Influenza A Virus, H1N1 Subtype / Q000276:immunology*; D007252:Influenza Vaccines / Q000008:administration & dosage* / Q000276:immunology*; D007251:Influenza, Human / Q000276:immunology / Q000517:prevention & control* / Q000821:virology; D007564:Japan; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged
chemical_list: D000914:Antibodies, Viral; D007252:Influenza Vaccines