title: Wound healing after radiation therapy: review of the literature.
abstract: Radiation therapy is an established modality in the treatment of head and neck cancer patients. Compromised wound healing in irradiated tissues is a common and challenging clinical problem. The pathophysiology and underlying cellular mechanisms including the complex interaction of cytokines and growth factors are still not understood completely. In this review, the current state of research regarding the pathomechanisms of compromised wound healing in irradiated tissues is presented. Current and possible future treatment strategies are critically reviewed.
authors.affiliation: Department of Otorhinolaryngology, Division of Facial Plastic Surgery, University of Regensburg, Regensburg, Germany. frank.haubner@klinik.uni-regensburg.de
authors.forename: Frank
authors.initials: F
authors.lastname: Haubner
authors.forename: Elisabeth
authors.initials: E
authors.lastname: Ohmann
authors.forename: Fabian
authors.initials: F
authors.lastname: Pohl
authors.forename: Jürgen
authors.initials: J
authors.lastname: Strutz
authors.forename: Holger G
authors.initials: HG
authors.lastname: Gassner
mesh_terms: D000465:Algorithms; D017690:Cell Transplantation / Q000379:methods; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins / Q000627:therapeutic use; D009369:Neoplasms / Q000150:complications / Q000532:radiotherapy*; D059351:Organ Sparing Treatments / Q000379:methods / Q000639:trends; D011855:Radiodermatitis / Q000188:drug therapy / Q000517:prevention & control / Q000628:therapy; D011878:Radiotherapy / Q000009:adverse effects* / Q000379:methods; D016038:Skin Transplantation / Q000706:statistics & numerical data; D014945:Wound Healing / Q000502:physiology / Q000528:radiation effects*
chemical_list: D036341:Intercellular Signaling Peptides and Proteins