title: [A silent-growing and fast-killing melanoma in a teenager].
abstract: Malignant melanoma is a relatively rare but potentially aggressive tumor in children and adolescents. We report the case of a metastatic malignant melanoma in a 17-year-old girl, first diagnosed on cytological features of a fine-needle lymph node aspiration and then histologically confirmed by both examination of the metastatic adenopathy and a clinically harmless skin lesion of the scalp, which harbored focal microscopic pattern of melanoma. A fluorescent in situ hybridization study revealed that both metastatic and primary cutaneous tumours contained the same and pejorative chromosomal aberration consisting in CCND1 amplification (11q13). This observation raises actual limits and challenges in the fields of diagnosis and treatment of fast-killing melanomas.
authors.affiliation: Service d'anatomie pathologique, pôle biologie-pathologie, CHRU de Brest, 2, avenue Foch, 29609 Brest cedex, France. arnaud.uguen@gmail.com
authors.forename: Arnaud
authors.initials: A
authors.lastname: Uguen
authors.forename: Matthieu
authors.initials: M
authors.lastname: Talagas
authors.forename: Isabelle
authors.initials: I
authors.lastname: Quintin-Roué
authors.forename: Claire
authors.initials: C
authors.lastname: Abasq
authors.forename: Charlotte
authors.initials: C
authors.lastname: Coat
authors.forename: Françoise
authors.initials: F
authors.lastname: Charles-Pétillon
authors.forename: Marc
authors.initials: M
authors.lastname: De Braekeleer
authors.forename: Pascale
authors.initials: P
authors.lastname: Marcorelles
mesh_terms: D000293:Adolescent; D000911:Antibodies, Monoclonal / Q000627:therapeutic use; D018906:Antineoplastic Agents, Alkylating / Q000627:therapeutic use; D001416:Back Pain / Q000209:etiology; D003131:Combined Modality Therapy; D019938:Cyclin D1 / Q000235:genetics; D003606:Dacarbazine / Q000627:therapeutic use; D019008:Drug Resistance, Neoplasm; D017809:Fatal Outcome; D005260:Female; D005784:Gene Amplification; D006258:Head and Neck Neoplasms / Q000175:diagnosis* / Q000188:drug therapy / Q000235:genetics / Q000473:pathology / Q000601:surgery; D006801:Humans; D007167:Immunotherapy; D017404:In Situ Hybridization, Fluorescence; D000074324:Ipilimumab; D008207:Lymphatic Metastasis / Q000175:diagnosis; D008545:Melanoma / Q000175:diagnosis* / Q000188:drug therapy / Q000235:genetics / Q000473:pathology / Q000556:secondary / Q000601:surgery; D009325:Nausea / Q000209:etiology; D009363:Neoplasm Proteins / Q000235:genetics; D016609:Neoplasms, Second Primary / Q000175:diagnosis* / Q000235:genetics / Q000473:pathology; D009506:Nevus / Q000473:pathology; D010014:Osteolysis / Q000209:etiology; D012535:Scalp / Q000473:pathology*; D012878:Skin Neoplasms / Q000175:diagnosis* / Q000235:genetics / Q000473:pathology; D015431:Weight Loss
chemical_list: D000911:Antibodies, Monoclonal; D018906:Antineoplastic Agents, Alkylating; C530104:CCND1 protein, human; D000074324:Ipilimumab; D009363:Neoplasm Proteins; D019938:Cyclin D1; D003606:Dacarbazine