title: Effect of cholecystokinin on rectal motor and sensory function in patients with irritable bowel syndrome and healthy controls.
abstract: OBJECTIVE
  Ingestion of a meal frequently induces an urge to defaecate, the so-called gastro-colonic or gastro-rectal reflex. In patients with irritable bowel syndrome (IBS), symptoms are often provoked by meals. Cholecystokinin (CCK), a proximal gut peptide released after ingestion of a meal, may mediate these postprandial changes. The potential role of CCK in rectal sensory and motor function was evaluated by a rectal barostat study in healthy controls and patients with IBS. METHOD ; The sensory effects on serosal and mucosal receptors were studied. Twelve healthy controls and 12 patients with IBS underwent a ramp distension procedure of the rectum during infusion of CCK and placebo in random order. In 10 other healthy controls and 10 IBS patients an intermittent distension procedure was performed during infusion of CCK and placebo in random order.
  
  
  RESULTS
  No differences were found in rectal compliance during ramp distensions between IBS patients and controls. CCK did not affect perception of urge and pain in controls or in IBS patients. Similar results were obtained during the intermittent distensions, but at higher distension pressures CCK significantly increased rectal sensitivity in IBS patients.
  
  
  CONCLUSIONS
  Infusion of exogenous CCK to plasma levels normally seen in the postprandial state did not influence rectal motor function or sensations during ramp distension but it did significantly increase pain sensation in IBS patients during rapid intermittent distension.
authors.affiliation: Department of Gastroenterology-Hepatology, Antonius Hospital Nieuwegein, Nieuwegein, The Netherlands.
authors.forename: P J
authors.initials: PJ
authors.lastname: van der Schaar
authors.forename: E
authors.initials: E
authors.lastname: van Hoboken
authors.forename: S
authors.initials: S
authors.lastname: Ludidi
authors.forename: A A M
authors.initials: AA
authors.lastname: Masclee
mesh_terms: D000328:Adult; D000704:Analysis of Variance; D016022:Case-Control Studies; D002756:Cholagogues and Choleretics / Q000494:pharmacology*; D002766:Cholecystokinin / Q000494:pharmacology*; D005260:Female; D005769:Gastrointestinal Motility / Q000187:drug effects*; D006801:Humans; D043183:Irritable Bowel Syndrome / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D019518:Postprandial Period; D011312:Pressure / Q000009:adverse effects; D011446:Prospective Studies; D012007:Rectum / Q000187:drug effects* / Q000294:innervation / Q000502:physiology; D012677:Sensation / Q000187:drug effects*; D059265:Visceral Pain / Q000209:etiology; D055815:Young Adult
chemical_list: D002756:Cholagogues and Choleretics; D002766:Cholecystokinin