title: GLP-1 expression in von Ebner's gland of diabetic rats.
abstract: GLP-1, a peptidergic endocrine hormone, which associate with appetite control, glucose homeostasis and satiety. It might play an important role in the gustatory system. We tried to investigate the expression of GLP-1 in von Ebner's gland of diabetic and control rats, and the ultrastructure changes on von Ebner's gland of diabetes rats. GLP-1 expression in von Ebner's gland was evaluated by immunohistochemistry. The number of GLP-1 positive cells in diabetic rat von Ebner's gland was significantly higher than that in normal controls. Electron micrographs showed that a series of pathologic changes in von Ebner's gland of diabetes rats. The results suggest that GLP-1 have some effects within the gustatory systems, and elevated von Ebner's gland GLP-1 expression may be one cause of diabetic taste impairment.
authors.affiliation: Department of Endocrinology, The First Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou 310006, China. fengxh_1991@163.com
authors.forename: Xiao-hong
authors.initials: XH
authors.lastname: Feng
authors.forename: Li-hong
authors.initials: LH
authors.lastname: Zhou
authors.forename: Dong
authors.initials: D
authors.lastname: Wang
authors.forename: Xiao
authors.initials: X
authors.lastname: Yuan
mesh_terms: D000818:Animals; D003921:Diabetes Mellitus, Experimental / Q000378:metabolism*; D052216:Glucagon-Like Peptide 1 / Q000378:metabolism*; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D013311:Streptozocin; D054838:von Ebner Glands / Q000378:metabolism* / Q000648:ultrastructure
chemical_list: D013311:Streptozocin; D052216:Glucagon-Like Peptide 1