title: A multifaceted prospective memory intervention to improve medication adherence: design of a randomized control trial.
abstract: Adherence to prescribed antihypertensive agents is critical because control of elevated blood pressure is the single most important way to prevent stroke and other end organ damage. Unfortunately, nonadherence remains a significant problem. Previous interventions designed to improve adherence have demonstrated only small benefits of strategies that target single facets such as understanding medication directions. The intervention described here is informed by prospective memory theory and performance of older adults in laboratory-based paradigms and uses a comprehensive, multifaceted approach to improve adherence. It incorporates multiple strategies designed to support key components of prospective remembering involved in taking medication. The intervention is delivered by nurses in the home with an education control group for comparison. Differences between groups in overall adherence following the intervention and 6 months later will be tested. Systolic and diastolic blood pressure levels also will be examined between groups and as they relate to adherence. Intra-individual regression is planned to examine change in adherence over time and its predictors. Finally, we will examine the association between executive function/working memory and adherence, predicting that adherence will be related to executive/working memory in the control group but not in the intervention group.
authors.affiliation: College of Nursing, University of Arizona, PO 210203, Tucson, AZ 85721, USA. insel@email.arizona.edu
authors.forename: Kathleen C
authors.initials: KC
authors.lastname: Insel
authors.forename: Gilles O
authors.initials: GO
authors.lastname: Einstein
authors.forename: Daniel G
authors.initials: DG
authors.lastname: Morrow
authors.forename: Joseph T
authors.initials: JT
authors.lastname: Hepworth
mesh_terms: D000368:Aged; D000959:Antihypertensive Agents / Q000627:therapeutic use*; D001794:Blood Pressure / Q000187:drug effects; D005260:Female; D006801:Humans; D006973:Hypertension / Q000188:drug therapy*; D008297:Male; D055118:Medication Adherence; D010349:Patient Compliance; D010353:Patient Education as Topic / Q000379:methods*; D011446:Prospective Studies; D016032:Randomized Controlled Trials as Topic / Q000379:methods*
chemical_list: D000959:Antihypertensive Agents