title: STOX1A induces phosphorylation of tau proteins at epitopes hyperphosphorylated in Alzheimer's disease.
abstract: Intraneuronal fibrillary tangles are a major hallmark of several neurodegenerative diseases including Alzheimer's disease. The major constituents of these hallmarks are hyper-phosphorylated tau. In this study we used a neuronal cellular model which over-expresses transcription factor STOX1A in combination with the longest human tau isoform to test the effect of STOX1A on tau phosphorylation. Our results show that STOX1A induces phosphorylation of the longest human tau isoform at phospho-epitopes typically found in neurofibrillary tangles in Alzheimer's disease. In conclusion, our results show a STOX1A-dependent effect on tau phosphorylation found in neurodegenerative diseases such as Alzheimer's disease.
authors.affiliation: Department of Clinical Chemistry, VU University Medical Center, Amsterdam, The Netherlands.
authors.forename: Daan
authors.initials: D
authors.lastname: van Abel
authors.forename: Omar
authors.initials: O
authors.lastname: Abdulhamid
authors.forename: Wiep
authors.initials: W
authors.lastname: Scheper
authors.forename: Marie
authors.initials: M
authors.lastname: van Dijk
authors.forename: Cees B M
authors.initials: CB
authors.lastname: Oudejans
mesh_terms: D000544:Alzheimer Disease / Q000378:metabolism*; D016203:CDC2 Protein Kinase / Q000378:metabolism; D002352:Carrier Proteins / Q000378:metabolism*; D045744:Cell Line, Tumor; D000939:Epitopes; D006801:Humans; D009474:Neurons / Q000378:metabolism*; D010766:Phosphorylation; D016875:tau Proteins / Q000378:metabolism*
chemical_list: D002352:Carrier Proteins; D000939:Epitopes; C500784:STOX1 protein, human; D016875:tau Proteins; D016203:CDC2 Protein Kinase