title: Tianjin Gestational Diabetes Mellitus Prevention Program: study design, methods, and 1-year interim report on the feasibility of lifestyle intervention program.
abstract: OBJECTIVE
  To assess whether lifestyle intervention can reduce type 2 diabetes risk in women with prior GDM in the Tianjin Gestational Diabetes Mellitus (GDM) Prevention Program.
  
  
  METHODS
  1180 women who were diagnosed with GDM from 2005 to 2009 were randomly assigned to either a lifestyle intervention (n=586) or a control group (n=594). Major elements of the intervention include six face-to-face meetings with study dietitians in the first year, and two additional sessions and two telephone calls in second year.
  
  
  RESULTS
  During the first year, average body weight loss in the first 404 subjects was 1.40 kg (2.1%) in the intervention group vs 0.21 kg (0.3%) in the control group (P=0.001), and the decrease was more significant among baseline overweight women (body bass index [BMI]≥24 kg/m²) in the intervention (2.91 kg/4.2%) compared with that in the control group (0.51 kg/0.7%) (P<0.001). In addition, women in the intervention group, compared with those in the control group, have decreased BMI, body fat, waist circumference, and plasma insulin levels, and have improved behaviors including increased leisure time activity and dietary fiber intake and decreased sedentary time and fat consumptions.
  
  
  CONCLUSIONS
  The interim results support the efficacy and feasibility of the lifestyle intervention program.
authors.affiliation: Pennington Biomedical Research Center, Baton Rouge, LA 70808, USA. gang.hu@pbrc.edu
authors.forename: Gang
authors.initials: G
authors.lastname: Hu
authors.forename: Huiguang
authors.initials: H
authors.lastname: Tian
authors.forename: Fuxia
authors.initials: F
authors.lastname: Zhang
authors.forename: Huikun
authors.initials: H
authors.lastname: Liu
authors.forename: Cuiping
authors.initials: C
authors.lastname: Zhang
authors.forename: Shuang
authors.initials: S
authors.lastname: Zhang
authors.forename: Leishen
authors.initials: L
authors.lastname: Wang
authors.forename: Gongshu
authors.initials: G
authors.lastname: Liu
authors.forename: Zhijie
authors.initials: Z
authors.lastname: Yu
authors.forename: Xilin
authors.initials: X
authors.lastname: Yang
authors.forename: Lu
authors.initials: L
authors.lastname: Qi
authors.forename: Cuilin
authors.initials: C
authors.lastname: Zhang
authors.forename: Hua
authors.initials: H
authors.lastname: Wang
authors.forename: Min
authors.initials: M
authors.lastname: Li
authors.forename: Junhong
authors.initials: J
authors.lastname: Leng
authors.forename: Yi
authors.initials: Y
authors.lastname: Li
authors.forename: Ling
authors.initials: L
authors.lastname: Dong
authors.forename: Jaakko
authors.initials: J
authors.lastname: Tuomilehto
mesh_terms: D000328:Adult; D015992:Body Mass Index; D002681:China; D015331:Cohort Studies; D003131:Combined Modality Therapy; D016640:Diabetes, Gestational / Q000208:ethnology / Q000209:etiology / Q000517:prevention & control*; D018752:Diet, Fat-Restricted / Q000208:ethnology; D004043:Dietary Fiber / Q000627:therapeutic use*; D005240:Feasibility Studies; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008019:Life Style / Q000208:ethnology; D008875:Middle Aged; D009043:Motor Activity; D050177:Overweight / Q000178:diet therapy / Q000208:ethnology / Q000503:physiopathology / Q000628:therapy*; D010353:Patient Education as Topic; D011247:Pregnancy; D055502:Secondary Prevention; D014504:Urban Health / Q000208:ethnology; D015431:Weight Loss / Q000208:ethnology; D055815:Young Adult