title: [Chronic inflammatory and dystrophic diseases of the eye anterior segment and their association with genetic polymorphisms in workers of metallurgic industry].
abstract: The ophthalmologic investigation of workers of the two metallurgical enterprises has shown that 1045 persons (55%) from 1911 observed workers suffer chronic diseases of a forward piece of eyes. Chronic inflammatory diseases (blepharitis, conjunctivitis and blepharoconjunctivitis) are found at 28,9% of them, and dystrophic diseases (pinguecula/pterygium)--at 25,8%. Among metallurgists (1801 persons) ophthalmopathy was found in 2, 2 times more often than at persons in control group (110 observed engineers and managers). Two polymorphisms of cytochrome P450 1A1 (CYP1A1) and P-450 2E1 (CYP2E1) genes were defined in 91 workers, by the method of allele-specific polymerase chain reaction. It is revealed that CYP1A1 Ile462Val polymorphism associates with pinguecula/pterygium, raising risk of their development almost in 3 times, unlike CYP 2E1 -1293G/C polymorphism. Development of chronic inflammatory diseases is not connected with tested polymorphisms.
authors.forename: M A
authors.initials: MA
authors.lastname: Mel'nichenko
authors.forename: N V
authors.initials: NV
authors.lastname: Mal'tseva
authors.forename: A L
authors.initials: AL
authors.lastname: Onishchenko
authors.forename: O F
authors.initials: OF
authors.lastname: Lykova
authors.forename: T V
authors.initials: TV
authors.lastname: Konysheva
authors.forename: V I
authors.initials: VI
authors.lastname: Zabelin
mesh_terms: D000328:Adult; D002908:Chronic Disease; D003229:Conjunctival Diseases / Q000201:enzymology / Q000453:epidemiology / Q000209:etiology* / Q000235:genetics; D019363:Cytochrome P-450 CYP1A1 / Q000235:genetics*; D019392:Cytochrome P-450 CYP2E1 / Q000235:genetics*; D005141:Eyelid Diseases / Q000201:enzymology / Q000453:epidemiology / Q000209:etiology* / Q000235:genetics; D005260:Female; D006801:Humans; D008297:Male; D008669:Metallurgy; D008875:Middle Aged; D009784:Occupational Diseases / Q000201:enzymology / Q000453:epidemiology / Q000209:etiology* / Q000235:genetics; D016273:Occupational Exposure / Q000517:prevention & control; D020641:Polymorphism, Single Nucleotide; D015995:Prevalence; D012426:Russia
chemical_list: D019392:Cytochrome P-450 CYP2E1; C569463:CYP1A1 protein, human; D019363:Cytochrome P-450 CYP1A1