title: Comparative efficacy of two treatment regimens combining in-office and at-home programs for dentin hypersensitivity relief: a 24-week clinical study.
abstract: OBJECTIVE
  Dentin hypersensitivity is a significant clinical problem that affects numerous individuals. This sharp pain, arising from exposed dentin in response to external stimuli, can be a particularly uncomfortable and unpleasant sensation for patients, because it interferes with their quality of life. The objective of this 24-week, single-center, parallel group, double-blind, stratified and randomized clinical study was to evaluate the clinical efficacy of a single professional treatment with an in-office desensitizing paste followed by twice daily brushing with a desensitizing toothpaste and toothbrush for 24 weeks.
  
  
  METHODS
  100 adults with confirmed dentin hypersensitivity were randomly assigned into two groups. One group received a single in-office treatment with a desensitizing paste containing 8% arginine and calcium carbonate (marketed as Colgate Sensitive Pro-Relief Desensitizing Paste and Elmex Sensitive Professional desensitizing paste), after dental scaling, followed by 24 weeks of brushing twice daily with a desensitizing toothpaste containing 8% arginine, calcium carbonate with 1450 ppm fluoride as MFP (marketed as Colgate Sensitive Pro-Relief toothpaste and Elmex Sensitive Professional toothpaste) and using the Colgate Sensitive Pro-Relief toothbrush (Test Group). The other group received a single in-office treatment with Nupro-M pumice prophylaxis paste, after dental scaling, followed by 24 weeks of brushing twice daily with a non-desensitizing toothpaste containing 1450 ppm fluoride as MFP and with the Oral-B Indicator toothbrush (Negative Control Group). Hypersensitivity was reexamined immediately after in-office product application and after 8 and 24 weeks of twice daily brushing.
  
  
  RESULTS
  Immediately after professional product application, and after 8 and 24 weeks, subjects assigned to the Test Group demonstrated statistically significant improvements in dentin hypersensitivity compared to subjects assigned to the Negative Control Group in tactile (49.8%, 57.5% and 32.9%, respectively) and air blast (26.0%, 38.4% and 34.3%, respectively) sensitivity scores. The instant reductions in dentin hypersensitivity provided by the single professional application of a desensitizing paste for in-office use, containing 8% arginine and calcium carbonate were maintained by twice daily brushing with the 8% arginine, calcium carbonate toothpaste with 1450 ppm fluoride as MFP and the Colgate Sensitive Pro-Relief toothbrush for at least 24 weeks.
authors.affiliation: Contract Dental Evaluations, Langhorne, Pennsylvania, USA.
authors.forename: David
authors.initials: D
authors.lastname: Hamlin
authors.forename: Luis R
authors.initials: LR
authors.lastname: Mateo
authors.forename: Serge
authors.initials: S
authors.lastname: Dibart
authors.forename: Evaristo
authors.initials: E
authors.lastname: Delgado
authors.forename: Yun Po
authors.initials: YP
authors.lastname: Zhang
authors.forename: William
authors.initials: W
authors.lastname: DeVizio
mesh_terms: D000328:Adult; D000368:Aged; D000704:Analysis of Variance; D001120:Arginine / Q000627:therapeutic use; D002130:Calcium Phosphates / Q000627:therapeutic use; D016009:Chi-Square Distribution; D045424:Complex Mixtures / Q000627:therapeutic use; D057133:Dentin Desensitizing Agents / Q000627:therapeutic use*; D003807:Dentin Sensitivity / Q000188:drug therapy*; D003959:Diamines / Q000627:therapeutic use*; D004311:Double-Blind Method; D004338:Drug Combinations; D005260:Female; D005459:Fluorides / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010710:Phosphates / Q000627:therapeutic use; D017680:Potassium Compounds / Q000627:therapeutic use*; D014099:Toothbrushing; D014100:Toothpastes / Q000627:therapeutic use*; D055815:Young Adult
chemical_list: D002130:Calcium Phosphates; D045424:Complex Mixtures; D057133:Dentin Desensitizing Agents; D003959:Diamines; D004338:Drug Combinations; D010710:Phosphates; D017680:Potassium Compounds; D014100:Toothpastes; C444700:colgate sensitive; C012980:fluorophosphate; C495399:Olaflur; D001120:Arginine; C020243:calcium phosphate; D005459:Fluorides