title: Hormone resistance in diabetes and obesity: insulin, leptin, and FGF21.
abstract: This an edited transcript of the Lee E. Farr Lecture given by Dr. Jeffrey Flier on May 8, 2012, at the culmination of the annual Student Research Day at the Yale School of Medicine. In this presentation, Dr. Flier discusses his and his wife's research on insulin, leptin, and FGF21 in the context of his reflections upon his life's work and his advice for young investigators.
authors.affiliation: Harvard University, Harvard Medical School, Boston, MA 02115, USA. Jeffrey_Flier@hms.harvard.edu
authors.forename: Jeffrey S
authors.initials: JS
authors.lastname: Flier
mesh_terms: D000273:Adipose Tissue / Q000378:metabolism / Q000503:physiopathology; D000818:Animals; D001835:Body Weight; D003920:Diabetes Mellitus / Q000235:genetics / Q000378:metabolism / Q000503:physiopathology*; D055423:Diet, Ketogenic; D005234:Fatty Liver / Q000378:metabolism / Q000503:physiopathology; D005346:Fibroblast Growth Factors / Q000235:genetics / Q000378:metabolism*; D006801:Humans; D007328:Insulin / Q000235:genetics / Q000378:metabolism*; D007333:Insulin Resistance; D020738:Leptin / Q000378:metabolism*; D051379:Mice; D018345:Mice, Knockout; D009765:Obesity / Q000378:metabolism / Q000503:physiopathology
chemical_list: D007328:Insulin; D020738:Leptin; C414620:fibroblast growth factor 21; D005346:Fibroblast Growth Factors