title: [The role of hyperinsulinemia and insulin resistance in development of chronic kidney disease in patients with metabolic syndrome].
abstract: OBJECTIVE
  To examine relations between hyperinsulinemia, insulin resistance (IR). components of metabolic syndrome (MS) and predisposition to renal damage,
  
  
  METHODS
  A total of 94 MS patients (64 males and 30 females, age 30-67 years, mean age 52 +/- 9 years) entered the study. The examination included measurement of waist and hip circumference, body mass index (BMI), HOMA index, estimation of lipids and immunoreactive insulin concentrations. Renal damage was assessed by glomerular filtration rate and urinary excretion of albumin. The patients were divided into groups by IR and BMI.
  
  
  RESULTS
  A strong correlation was found between IR markers and lipid metabolism disorders, hemodynamic parameters. Statistics show that IR is an independent unfavourable factor of renal damage in MS patients.
  
  
  CONCLUSIONS
  IR is an essential component of MS and an independent factor of development of chronic kidney disease in MS patients.
authors.forename: I M
authors.initials: IM
authors.lastname: Kutyrina
authors.forename: A A
authors.initials: AA
authors.lastname: Kriachkova
authors.forename: S A
authors.initials: SA
authors.lastname: Savel'eva
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000097:blood; D001786:Blood Glucose / Q000032:analysis; D001794:Blood Pressure / Q000502:physiology; D015992:Body Mass Index; D001835:Body Weight / Q000502:physiology; D005260:Female; D006801:Humans; D006946:Hyperinsulinism / Q000097:blood / Q000150:complications* / Q000000981:diagnostic imaging; D007328:Insulin / Q000097:blood; D007333:Insulin Resistance; D007677:Kidney Function Tests; D050356:Lipid Metabolism / Q000502:physiology; D008055:Lipids / Q000097:blood; D008297:Male; D024821:Metabolic Syndrome / Q000097:blood / Q000150:complications* / Q000000981:diagnostic imaging; D008875:Middle Aged; D051436:Renal Insufficiency, Chronic / Q000097:blood / Q000000981:diagnostic imaging / Q000209:etiology*; D014463:Ultrasonography; D055105:Waist Circumference
chemical_list: D015415:Biomarkers; D001786:Blood Glucose; D007328:Insulin; D008055:Lipids