title: Total antioxidant capacity from diet and risk of myocardial infarction: a prospective cohort of women.
abstract: BACKGROUND
  There are no previous studies investigating the effect of all dietary antioxidants in relation to myocardial infarction. The total antioxidant capacity of diet takes into account all antioxidants and synergistic effects between them. The aim of this study was to examine how total antioxidant capacity of diet and antioxidant-containing foods were associated with incident myocardial infarction among middle-aged and elderly women.
  
  
  METHODS
  In the population-based prospective Swedish Mammography Cohort of 49-83-year-old women, 32,561 were cardiovascular disease-free at baseline. Women completed a food-frequency questionnaire, and dietary total antioxidant capacity was calculated using oxygen radical absorbance capacity values. Information on myocardial infarction was identified from the Swedish Hospital Discharge and the Cause of Death registries. Hazard ratios (HR) and 95% confidence intervals (CI) were calculated using Cox proportional hazard models.
  
  
  RESULTS
  During the follow-up (September 1997-December 2007), we identified 1114 incident cases of myocardial infarction (321,434 person-years). In multivariable-adjusted analysis, the HR for women comparing the highest quintile of dietary total antioxidant capacity to the lowest was 0.80 (95% CI, 0.67-0.97; P for trend=0.02). Servings of fruit and vegetables and whole grains were nonsignificantly inversely associated with myocardial infarction.
  
  
  CONCLUSIONS
  These data suggest that dietary total antioxidant capacity, based on fruits, vegetables, coffee, and whole grains, is of importance in the prevention of myocardial infarction.
authors.affiliation: Division of Nutritional Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden. susanne.rautiainen@ki.se
authors.forename: Susanne
authors.initials: S
authors.lastname: Rautiainen
authors.forename: Emily B
authors.initials: EB
authors.lastname: Levitan
authors.forename: Nicola
authors.initials: N
authors.lastname: Orsini
authors.forename: Agneta
authors.initials: A
authors.lastname: Åkesson
authors.forename: Ralf
authors.initials: R
authors.lastname: Morgenstern
authors.forename: Murray A
authors.initials: MA
authors.lastname: Mittleman
authors.forename: Alicja
authors.initials: A
authors.lastname: Wolk
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000975:Antioxidants; D003069:Coffee; D015331:Cohort Studies; D004032:Diet; D004034:Diet Surveys; D002523:Edible Grain; D005260:Female; D005638:Fruit; D006801:Humans; D008875:Middle Aged; D015999:Multivariate Analysis; D009203:Myocardial Infarction / Q000209:etiology / Q000517:prevention & control*; D016016:Proportional Hazards Models; D011446:Prospective Studies; D012042:Registries; D011795:Surveys and Questionnaires; D013548:Sweden; D014675:Vegetables
chemical_list: D000975:Antioxidants; D003069:Coffee