title: In vivo/in vitro studies of the effects of the type II arabinogalactan isolated from Maytenus ilicifolia Mart. ex Reissek on the gastrointestinal tract of rats.
abstract: Type II arabinogalactan (AG) is a polysaccharide found in Maytenus ilicifolia (Celastraceae), a plant reputed as gastroprotective. Oral and intraperitoneal administration of the AG protected rats from gastric ulcers induced by ethanol. No alteration of mechanisms related to acid gastric secretion and gastrointestinal motility were observed. In vitro, the AG showed a potent scavenging activity against the radical of DPPH (2,2-diphenyl-1-picrylhydrazyl) with an IC50 value of 9.3 microM. However, the mechanism of the gastroprotective action remains to be identified.
authors.affiliation: Department of Pharmacology, Sector of Biological Sciences, Universidade Federal do Paraná, Curitiba, PR, Brazil. crisbaggio@hotmail.com
authors.forename: Cristiane H
authors.initials: CH
authors.lastname: Baggio
authors.forename: Cristina S
authors.initials: CS
authors.lastname: Freitas
authors.forename: André
authors.initials: A
authors.lastname: Twardowschy
authors.forename: Ana Cristina
authors.initials: AC
authors.lastname: dos Santosa
authors.forename: Bárbara
authors.initials: B
authors.lastname: Mayer
authors.forename: Francine B
authors.initials: FB
authors.lastname: Potrich
authors.forename: Thales R
authors.initials: TR
authors.lastname: Cipriani
authors.forename: Guilherme L
authors.initials: GL
authors.lastname: Sassaki
authors.forename: Marcello
authors.initials: M
authors.lastname: Iacomini
authors.forename: Maria Consuelo A
authors.initials: MC
authors.lastname: Marques
authors.forename: Sonia
authors.initials: S
authors.lastname: Mesia-Velaa
mesh_terms: D000818:Animals; D005260:Female; D005685:Galactans / Q000302:isolation & purification / Q000494:pharmacology*; D041981:Gastrointestinal Tract / Q000187:drug effects*; D066298:In Vitro Techniques; D029755:Maytenus / Q000737:chemistry*; D051381:Rats; D017208:Rats, Wistar
chemical_list: D005685:Galactans; C005653:arabinogalactan