title: Access to sultams by rhodium(III)-catalyzed directed C-H activation.
abstract: Director's cut: The pharmaceutically relevant sulfonamide group is shown to be a competent directing group for [Cp*Rh(OAc)(2)]-catalyzed C-H functionalizations. Reactions of the cyclometalated intermediate with internal alkynes provide access to a wide range of sultam derivatives. The reaction is high yielding and works best under aerobic conditions with catalytic amounts of CuOAc as an oxidation mediator. Cp* = C(5)Me(5).
authors.affiliation: Laboratory of Asymmetric Catalysis and Synthesis, EPFL SB ISIC LCSA, BCH 4305, CH-1015 Lausanne, Switzerland.
authors.forename: Manh V
authors.initials: MV
authors.lastname: Pham
authors.forename: Baihua
authors.initials: B
authors.lastname: Ye
authors.forename: Nicolai
authors.initials: N
authors.lastname: Cramer
mesh_terms: D000480:Alkynes; D002244:Carbon / Q000737:chemistry*; D002384:Catalysis; D003500:Cyclization; D006571:Heterocyclic Compounds / Q000737:chemistry*; D006859:Hydrogen / Q000737:chemistry*; D012238:Rhodium / Q000737:chemistry*; D013449:Sulfonamides / Q000737:chemistry*
chemical_list: D000480:Alkynes; D006571:Heterocyclic Compounds; D013449:Sulfonamides; D002244:Carbon; D006859:Hydrogen; D012238:Rhodium