title: [Advance in the study of targeting delivery system for siRNA mediated by aptamers].
abstract: RNA interference (RNAi), as a new technology of gene therapy, has been used in the studies of many diseases in vitro, however, targeting delivery of small interference RNA (siRNA) is still a bottleneck for clinical therapy of siRNA agents. Aptamer is a group of oligonucleotides with high affinity and targeting, and is becoming another important means of delivery for siRNA. In this review, we summarized siRNA delivery obstacles in vivo and recent attractive developments increatively using cell-internalizing aptamers to deliver siRNAs to target cells.
authors.affiliation: Guangxi Medical University, Nanning 530002, China.
authors.forename: Xiao-Lin
authors.initials: XL
authors.lastname: Wang
authors.forename: Qing-Qing
authors.initials: QQ
authors.lastname: Wang
authors.forename: Hai-Feng
authors.initials: HF
authors.lastname: Song
mesh_terms: D052157:Aptamers, Nucleotide / Q000008:administration & dosage / Q000378:metabolism*; D016503:Drug Delivery Systems / Q000379:methods*; D006801:Humans; D009369:Neoplasms / Q000628:therapy*; D034622:RNA Interference; D034741:RNA, Small Interfering / Q000008:administration & dosage / Q000378:metabolism*; D052156:SELEX Aptamer Technique
chemical_list: D052157:Aptamers, Nucleotide; D034741:RNA, Small Interfering