title: [Relevance of long non-coding RNAs in tumour biology].
abstract: The discovery of the biological relevance of non-coding RNA molecules represents one of the most significant advances in contemporary molecular biology. It has turned out that a major fraction of the non-coding part of the genome is transcribed. Beside small RNAs (including microRNAs) more and more data are disclosed concerning long non-coding RNAs of 200 nucleotides to 100 kb length that are implicated in the regulation of several basic molecular processes (cell proliferation, chromatin functioning, microRNA-mediated effects, etc.). Some of these long non-coding RNAs have been associated with human tumours, including H19, HOTAIR, MALAT1, etc., the different expression of which has been noted in various neoplasms relative to healthy tissues. Long non-coding RNAs may represent novel markers of molecular diagnostics and they might even turn out to be targets of therapeutic intervention.
authors.affiliation: Semmelweis Egyetem, Általános Orvostudományi Kar II. Belgyógyászati Klinika Budapest.
authors.forename: Zoltán
authors.initials: Z
authors.lastname: Nagy
authors.forename: Diána Rita
authors.initials: DR
authors.lastname: Szabó
authors.forename: Adrienn
authors.initials: A
authors.lastname: Zsippai
authors.forename: András
authors.initials: A
authors.lastname: Falus
authors.forename: Károly
authors.initials: K
authors.lastname: Rácz
authors.forename: Péter
authors.initials: P
authors.lastname: Igaz
mesh_terms: D006801:Humans; D009369:Neoplasms / Q000235:genetics* / Q000378:metabolism; D022661:RNA, Untranslated / Q000235:genetics / Q000378:metabolism / Q000627:therapeutic use
chemical_list: D022661:RNA, Untranslated