title: Microbial transformation of 20(S)-protopanaxatriol by Absidia corymbifera and their cytotoxic activities against two human prostate cancer cell lines.
abstract: Seven hydroxylates of 20(S)-protopanaxatriol (1) transformed by Absidia corymbifera AS 3.3387 were isolated and identified by spectral methods including 2D-NMR. Among them, 7β-hydroxyl-20(S)-protopanaxatriol (2), 7α-hydroxyl-20(S)-protopanaxatriol (3), and 7β, 15α-dihydroxyl-20(S)-protopanaxatriol (7) are new compounds. The metabolites 2, 6, 7, and 8 showed the more potent inhibitory effects against DU-145 and PC-3 cell lines than the substrate.
authors.affiliation: School of Medicine, Nantong University, Nantong, People's Republic of China. guangtong_chen@163.com
authors.forename: Guangtong
authors.initials: G
authors.lastname: Chen
authors.forename: Xue
authors.initials: X
authors.lastname: Yang
authors.forename: Xuguang
authors.initials: X
authors.lastname: Zhai
authors.forename: Min
authors.initials: M
authors.lastname: Yang
mesh_terms: D020095:Absidia / Q000378:metabolism*; D000970:Antineoplastic Agents / Q000737:chemistry / Q000493:pharmacokinetics* / Q000494:pharmacology*; D001711:Biotransformation; D016923:Cell Death / Q000187:drug effects*; D045744:Cell Line, Tumor; D006801:Humans; D008297:Male; D008958:Models, Molecular; D019906:Nuclear Magnetic Resonance, Biomolecular; D011471:Prostatic Neoplasms / Q000188:drug therapy* / Q000378:metabolism; D012502:Sapogenins / Q000737:chemistry / Q000493:pharmacokinetics* / Q000494:pharmacology*
chemical_list: D000970:Antineoplastic Agents; D012502:Sapogenins; C081552:protopanaxatriol