title: Perspectives on brain-targeting drug delivery systems.
abstract: Due to the presence of the blood-brain barrier, there is limited drug access into the brain. In order to overcome this challenge, various strategies have been developed to enhance penetration of drugs into the brain. Of these, the most frequently used are pharmacological technologies or comparable methods being developed for brain-targeting drug delivery using receptor- or adsorptive- or transporter-mediated transcytosis and the nose-to-brain route. It goes without saying that exploration of Brain-targeting drug delivery systems has created another potential option for the treatment of central nervous system diseases. In addition to above methods, other technologies for brain-targeting drug delivery (e.g. chemical delivery systems, prodrugs, pharmacological disruption of the BBB and inhibition of drug efflux by P-glycoprotein) are also summarized in this review.
authors.affiliation: School of Pharmacy, Fudan University, Shanghai, P.R. China.
authors.forename: Liangran
authors.initials: L
authors.lastname: Guo
authors.forename: Jinfeng
authors.initials: J
authors.lastname: Ren
authors.forename: Xinguo
authors.initials: X
authors.lastname: Jiang
mesh_terms: D000818:Animals; D001921:Brain / Q000378:metabolism*; D002493:Central Nervous System Diseases / Q000188:drug therapy / Q000378:metabolism; D016503:Drug Delivery Systems; D004705:Endocytosis; D006801:Humans; D026901:Membrane Transport Proteins / Q000378:metabolism; D009296:Nasal Cavity / Q000378:metabolism
chemical_list: D026901:Membrane Transport Proteins