title: Study of skin anti-ageing and anti-inflammatory effects of dihydroquercetin, natural triterpenoids, and their synthetic derivatives.
abstract: Accessible triterpenoids of ursane and lupane series, the flavonoid dihydroquercetin and their synthetic derivatives with polar substituentss were tested in vitro for inhibition of collagenase 1 (MMP-1) in UVB irradiation assay. Ursolic acid and uvaol disuccinate were the most active inhibitors in the ursane series. In the lupane series, the best inhibition was manifested by carboxymethyl ester of betulonic acid and betulin succinates. Down- regulation of MMP-1 by dihydroquercetin and its synthetic derivatives surpassed the activity of a standard (retinoic acid).
authors.affiliation: Amore-Pacific Co. R&D Center, 314-1, Bora-dong, Giheung-gu, Yongin-si, Gyeonggi-Do, 446-729, Republic of Korea.
authors.forename: Chan Woo
authors.initials: CW
authors.lastname: Lee
authors.forename: Nok Hyun
authors.initials: NH
authors.lastname: Park
authors.forename: Jin Woong
authors.initials: JW
authors.lastname: Kim
authors.forename: Byung Hun
authors.initials: BH
authors.lastname: Um
authors.forename: A V
authors.initials: AV
authors.lastname: Shpatov
authors.forename: E E
authors.initials: EE
authors.lastname: Shults
authors.forename: I V
authors.initials: IV
authors.lastname: Sorokina
authors.forename: S A
authors.initials: SA
authors.lastname: Popov
mesh_terms: D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000737:chemistry / Q000494:pharmacology*; D002460:Cell Line; D005347:Fibroblasts / Q000187:drug effects; D006801:Humans; D016209:Interleukin-8 / Q000037:antagonists & inhibitors; D015603:Keratinocytes / Q000187:drug effects; D020781:Matrix Metalloproteinase 1; D009828:Oleanolic Acid / Q000031:analogs & derivatives / Q000737:chemistry / Q000494:pharmacology; D011794:Quercetin / Q000031:analogs & derivatives* / Q000737:chemistry / Q000494:pharmacology; D015595:Skin Aging / Q000187:drug effects*; D014212:Tretinoin / Q000737:chemistry / Q000494:pharmacology; D014315:Triterpenes / Q000737:chemistry / Q000494:pharmacology*; D014466:Ultraviolet Rays; D000097245:Ursolic Acid; D000094062:Betulinic Acid; D053978:Pentacyclic Triterpenes
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D016209:Interleukin-8; D020781:Matrix Metalloproteinase 1; D009828:Oleanolic Acid; D011794:Quercetin; D014212:Tretinoin; D014315:Triterpenes; D000097245:Ursolic Acid; C118308:betulonic acid; D000094062:Betulinic Acid; C480546:lupane; D053978:Pentacyclic Triterpenes; C002503:betulin; C003377:taxifolin; C522360:MMP1 protein, human; C013330:uvaol