title: Cutaneous leukocytoclastic vasculitis due to Salmonella enteritidis in a child with interleukin-12 receptor beta-1 deficiency.
abstract: Defects in the interleukin 12 (IL-12)/interferon gamma (IFN-γ) pathway result in Mendelian susceptibility to mycobacterial disease (MSMD). IL-12 receptor beta 1 (IL-12Rβ1) deficiency, the most common form of MSMD, is associated with weakly virulent mycobacteria and salmonella. Infections in patients with this deficiency are extraintestinal, or septicemic, recurrent infections with nontyphoid salmonellae. Here we report a case of an IL-12Rβ1 deficiency with cutaneous leukocytoclastic vasculitis due to Salmonella enteritidis.
authors.affiliation: Department of Pediatric Allergy and Immunology, Akdeniz University School of Medicine, Antalya, TurkeyDepartment of Pediatric Hematology, Akdeniz University School of Medicine, Antalya, TurkeyDepartment of Pathology, Akdeniz University School of Medicine, Antalya, TurkeyDepartment of Infectious Diseases, Leiden University Medical Center, Leiden, The Netherlands.
authors.forename: Serkan
authors.initials: S
authors.lastname: Filiz
authors.forename: Dilara F
authors.initials: DF
authors.lastname: Kocacik Uygun
authors.forename: Els M
authors.initials: EM
authors.lastname: Verhard
authors.forename: Jaap T
authors.initials: JT
authors.lastname: van Dissel
authors.forename: Vedat
authors.initials: V
authors.lastname: Uygun
authors.forename: Cumhur
authors.initials: C
authors.lastname: Bassorgun
authors.forename: Aysen
authors.initials: A
authors.lastname: Bingol
authors.forename: Olcay
authors.initials: O
authors.lastname: Yegin
authors.forename: Esther
authors.initials: E
authors.lastname: van de Vosse
mesh_terms: D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D001706:Biopsy; D002443:Ceftriaxone / Q000627:therapeutic use; D002675:Child, Preschool; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D053707:Receptors, Interleukin-12 / Q000172:deficiency*; D012477:Salmonella enteritidis / Q000302:isolation & purification*; D018366:Vasculitis, Leukocytoclastic, Cutaneous / Q000188:drug therapy / Q000235:genetics / Q000382:microbiology*
chemical_list: D000900:Anti-Bacterial Agents; D053707:Receptors, Interleukin-12; D002443:Ceftriaxone