title: Infection retardant coated inflatable penile prostheses decrease the incidence of infection: a systematic review and meta-analysis.
abstract: OBJECTIVE
  This systematic review was done to compare the effectiveness of infection retardant coated inflatable penile prostheses vs noncoated devices.
  
  
  METHODS
  We systematically reviewed PubMed® and Galileo® to identify all relevant case studies. The postoperative infection incidence rate was compared for coated and noncoated inflatable penile prostheses to determine whether coating the implant affects the rate of surgical implant infection.
  
  
  RESULTS
  Included in analysis were 14 clinical case studies in a total of 9,910 patients with a first time implant, including 5,214 inflatable penile prostheses without an infection retardant coating and 4,696 coated inflatable penile prostheses impregnated with minocycline/rifampin (3,158), rifampin/gentamycin immersion (181), vancomycin/gentamycin immersion (181) and a hydrophilic coating only (1,176). For noncoated vs coated prostheses the infection rate was 2.32% vs 0.89% (p <0.01), including 0.63%, 0.55%, 4.42% and 1.11% for minocycline/rifampin, rifampin/gentamycin immersion, vancomycin/gentamycin immersion and hydrophilic coatings, respectively.
  
  
  CONCLUSIONS
  This analysis documents a significant advantage of using coated compared to noncoated inflatable penile prostheses to prevent postoperative device infection. Infection retardant coatings that allow antibiotics to elute off the device components decrease the incidence of device infection by approximately 50%. Future studies must address novel techniques, such as preventing bacterial adhesion, to further decrease infectious etiologies.
authors.affiliation: Department of Urology, Tulane University, New Orleans, Louisiana 70112, USA.
authors.forename: Sree Harsha
authors.initials: SH
authors.lastname: Mandava
authors.forename: Ege Can
authors.initials: EC
authors.lastname: Serefoglu
authors.forename: Matthew T
authors.initials: MT
authors.lastname: Freier
authors.forename: Steven K
authors.initials: SK
authors.lastname: Wilson
authors.forename: Wayne J G
authors.initials: WJ
authors.lastname: Hellstrom
mesh_terms: D000900:Anti-Bacterial Agents / Q000008:administration & dosage*; D020099:Coated Materials, Biocompatible; D006801:Humans; D015994:Incidence; D008297:Male; D015917:Penile Prosthesis; D011474:Prosthesis Design; D016459:Prosthesis-Related Infections / Q000453:epidemiology* / Q000517:prevention & control*
chemical_list: D000900:Anti-Bacterial Agents; D020099:Coated Materials, Biocompatible