title: Myocardial fatty acid metabolism and lipotoxicity in the setting of insulin resistance.
abstract: Management of diabetes and insulin resistance in the setting of cardiovascular disease has become an important issue in an increasingly obese society. Besides the development of hypertension and buildup of atherosclerotic plaques, the derangement of fatty acid and lipid metabolism in the heart plays an important role in promoting cardiac dysfunction and oxidative stress. This review discusses the mechanisms by which metabolic inflexibility in the use of fatty acids as the preferred cardiac substrate in diabetes produces detrimental effects on mechanical efficiency, mitochondrial function, and recovery from ischemia. Lipid accumulation and the consequences of toxic lipid metabolites are also discussed.
authors.affiliation: Signal Transduction Research Group, Department of Biochemistry, School of Translational Medicine, University of Alberta, 11207 87th Avenue, Edmonton, Alberta, Canada.
authors.forename: Bernard P C
authors.initials: BP
authors.lastname: Kok
authors.forename: David N
authors.initials: DN
authors.lastname: Brindley
mesh_terms: D002318:Cardiovascular Diseases / Q000209:etiology / Q000473:pathology; D058065:Diabetic Cardiomyopathies / Q000209:etiology* / Q000378:metabolism / Q000473:pathology; D004721:Endoplasmic Reticulum; D005227:Fatty Acids / Q000378:metabolism*; D006801:Humans; D006943:Hyperglycemia / Q000150:complications* / Q000473:pathology; D006949:Hyperlipidemias / Q000150:complications* / Q000378:metabolism / Q000473:pathology; D007333:Insulin Resistance; D008928:Mitochondria; D009206:Myocardium / Q000378:metabolism* / Q000473:pathology; D032383:Myocytes, Cardiac; D018384:Oxidative Stress; D012307:Risk Factors
chemical_list: D005227:Fatty Acids