title: Intractable hypotension and myocardial ischaemia induced by co-ingestion of ethanol and disulfiram.
abstract: We report a case of a 42-year-old woman who presented with intractable hypotension and non-ST-elevation myocardial infarction as a result of a disulfiram-ethanol reaction. During hypotension and ischaemic ECG changes we assessed cardiac function by echocardiography. Aggressive intravenous fluid resuscitation was unsuccessful. Only after starting intravenous norepinephrine, blood pressure and ECG normalized. Coronary angiography performed three days after admission was normal. Cardiovascular adverse events are a known, potentially fatal complication of concomitant ingestion of ethanol and disulfiram, but only few cases are reported in literature. Cardiologists and emergency care physicians should be aware of this interaction when a patient with chronic alcohol abuse presents with severe hypotension or myocardial ischaemia.
authors.affiliation: Department of Cardiology, UZLeuven, Leuven, Belgium. sofiemoreels@yahoo.com
authors.forename: Sofie
authors.initials: S
authors.lastname: Moreels
authors.forename: Ann
authors.initials: A
authors.lastname: Neyrinck
authors.forename: Walter
authors.initials: W
authors.lastname: Desmet
mesh_terms: D000328:Adult; D000427:Alcohol Deterrents / Q000009:adverse effects*; D000435:Alcoholic Intoxication / Q000150:complications*; D000437:Alcoholism / Q000150:complications; D004221:Disulfiram / Q000009:adverse effects*; D004562:Electrocardiography; D005260:Female; D006801:Humans; D007022:Hypotension / Q000139:chemically induced / Q000209:etiology*; D009203:Myocardial Infarction / Q000139:chemically induced / Q000209:etiology*
chemical_list: D000427:Alcohol Deterrents; D004221:Disulfiram