title: NF-kappaB activation: Tax sumoylation is out, but what about Tax ubiquitination?
abstract: Activation of the NF-κB transcription factors by the viral protein Tax plays a vital role in the pathogenesis of diseases associated with human T-cell lymphotropic virus type I (HTLV-I). The Tax oncoprotein undergoes constitutive K63-linked ubiquitination and sumoylation; however, the roles and molecular mechanisms of these post-translational modifications in Tax-mediated NF-κB activation are being debated. Here, we discuss our current understanding of Tax activation of NF-κB, with a focus on the controversies and the challenges that we are facing.
authors.affiliation: University of Pittsburgh Cancer Institute, University of Pittsburgh Medical Centers, Pittsburgh, PA 15213, USA. xiaog2@upmc.edu
authors.forename: Gutian
authors.initials: G
authors.lastname: Xiao
mesh_terms: D016356:Gene Products, tax / Q000378:metabolism*; D054884:Host-Pathogen Interactions; D015368:Human T-lymphotropic virus 1 / Q000472:pathogenicity*; D006801:Humans; D008954:Models, Biological; D016328:NF-kappa B / Q000276:immunology* / Q000378:metabolism*; D058207:Sumoylation; D054875:Ubiquitination
chemical_list: D016356:Gene Products, tax; D016328:NF-kappa B; C514970:tax protein, Human T-lymphotrophic virus 1