title: The influence of compatibility of traditional Chinese medicine on the pharmacokinetic of main components in Fructus aurantii.
abstract: BACKGROUND
  Fructus Aurantii is one of the commonly used traditional Chinese medicines and the compatibility of Fructus Aurantii, Radix et Rhizoma Rhei and Semen Crotonis Pulveratum were the main components in a Chinese traditional patent medicine Weichang'an pill. Naringin and neohesperidin are two main flavonoid glycosides in the extract of Fructus Aurantii. The pharmacokinetics of naringin and neohesperidin, as the main marker constituents were analysis by a simple and accurate method.
  
  
  METHODS
  In the present study, pharmacokinetic differences of two flavonoid glycosides were detected after oral administration of the extract of single herb and different compatibility of Fructus Aurantii, Radix et Rhizoma Rhei and Semen Crotonis Pulveratum which at doses of approximately 700 mg/kg naringin and 300 mg/kg neohesperidin.
  
  
  RESULTS
  It indicated that the pharmacokinetic process of naringin and neohesperidin in four groups were demonstrated bimodal phenomenon after oral administration. Comparing to pharmacokinetic parameters of the single herbs administration, there were no significant difference after the compatibility of Fructus Aurantii and Radix et Rhizoma Rhei. However, the absorption of two flavonoid glycosides was increased dramatically after the compatibility of Fructus Aurantii or Semen Crotonis Pulveratum. The same results were attained after co-administration of the extract of three herbs.
  
  
  CONCLUSIONS
  Some components in the extract of Semen Crotonis Pulveratum promoted the absorption of naringin and neohesperidin.
authors.affiliation: School of Pharmaceutical Science and Technology, Tianjin University, Weijin Road, Tianjin, China.
authors.forename: Jingze
authors.initials: J
authors.lastname: Zhang
authors.forename: Wenyuan
authors.initials: W
authors.lastname: Gao
authors.forename: Xiao
authors.initials: X
authors.lastname: Hu
authors.forename: Zhen
authors.initials: Z
authors.lastname: Liu
authors.forename: Changxiao
authors.initials: C
authors.lastname: Liu
mesh_terms: D000818:Animals; D002957:Citrus; D004365:Drugs, Chinese Herbal / Q000032:analysis / Q000493:pharmacokinetics*; D006027:Glycosides / Q000032:analysis / Q000493:pharmacokinetics*; D008297:Male; D008516:Medicine, Chinese Traditional; D051381:Rats; D017208:Rats, Wistar
chemical_list: D004365:Drugs, Chinese Herbal; D006027:Glycosides