title: Autoimmune manifestations in large granular lymphocyte leukemia.
abstract: Large granular lymphocyte (LGL) leukemia features a group of indolent lymphoproliferative diseases that display a strong association with various autoimmune conditions. Notwithstanding, these autoimmune conditions have not been comprehensively characterized or systematized to date. As a result, their clinical implications remain largely unknown. The authors offer a comprehensive review of the existing literature on various autoimmune conditions documented in the course of T-cell LGL (T-LGL) leukemia. Though some of them are thought be secondary to the LGL leukemia, others could be primary and might even play a role in its pathogenesis. A considerable clinico-laboratory overlap between T-LGL leukemia associated with rheumatoid arthritis and Felty's syndrome suggests that they are just different eponyms for the same clinical entity.
authors.affiliation: Department of Medicine, University of Connecticut Medical Center, Farmington, CT 06030-1235, USA. bbockorny@resident.uchc.edu
authors.forename: Bruno
authors.initials: B
authors.lastname: Bockorny
authors.forename: Constantin A
authors.initials: CA
authors.lastname: Dasanu
mesh_terms: D001172:Arthritis, Rheumatoid / Q000276:immunology / Q000473:pathology; D005258:Felty Syndrome / Q000276:immunology / Q000473:pathology; D006801:Humans; D054066:Leukemia, Large Granular Lymphocytic / Q000276:immunology* / Q000473:pathology