title: miR-134 inhibits epithelial to mesenchymal transition by targeting FOXM1 in non-small cell lung cancer cells.
abstract: Recent studies have implied that miRNAs act as crucial modulators for epithelial-to-mesenchymal transition (EMT). We found that miR-134 expression correlated with invasive potential and EMT phenotype of NSCLC cells. Functional assays demonstrated that miR-134 inhibited EMT in NSCLC cells. In addition, we showed that Forkhead Box M1 (FOXM1) is a direct target of miR-134. Knockdown of FOXM1 reversed EMT resembling that of miR-134 overexpression. We further found that FOXM1 was involved in TGF-β1-induced EMT in A549 cells. These findings suggest that miR-134 acts as a novel EMT suppressor in NSCLC cells.
authors.affiliation: Department of Clinical Laboratory, Yinzhou People's Hospital, Ningbo 315040, China.
authors.forename: Jipeng
authors.initials: J
authors.lastname: Li
authors.forename: Yiping
authors.initials: Y
authors.lastname: Wang
authors.forename: Jianping
authors.initials: J
authors.lastname: Luo
authors.forename: Zhongming
authors.initials: Z
authors.lastname: Fu
authors.forename: Jianfei
authors.initials: J
authors.lastname: Ying
authors.forename: Yanhong
authors.initials: Y
authors.lastname: Yu
authors.forename: Wanjun
authors.initials: W
authors.lastname: Yu
mesh_terms: D001483:Base Sequence; D002289:Carcinoma, Non-Small-Cell Lung / Q000473:pathology*; D045744:Cell Line, Tumor; D058750:Epithelial-Mesenchymal Transition / Q000187:drug effects / Q000235:genetics*; D000072278:Forkhead Box Protein M1; D051858:Forkhead Transcription Factors / Q000235:genetics*; D015972:Gene Expression Regulation, Neoplastic / Q000187:drug effects; D006801:Humans; D008175:Lung Neoplasms / Q000473:pathology*; D035683:MicroRNAs / Q000235:genetics / Q000378:metabolism*; D009361:Neoplasm Invasiveness; D053773:Transforming Growth Factor beta1 / Q000494:pharmacology
chemical_list: C107585:FOXM1 protein, human; D000072278:Forkhead Box Protein M1; D051858:Forkhead Transcription Factors; C569273:MIRN134 microRNA, human; D035683:MicroRNAs; D053773:Transforming Growth Factor beta1