title: [Identification of hydrolysates and alcoholysates of aconitum alkaloids].
abstract: OBJECTIVE
  To identify products decomposed in high temperature water and alcohol from diester alkaloids such as aconitum alkaloid, in order to study their transformation regularity.
  
  
  METHODS
  Structures of multiple converted products were determined by analyzing on multistage mass spectrometry of known compounds and literature searching.
  
  
  RESULTS
  Benzaconine and pyraconitine were the major hydrolysates, while pyraconitine and ethoxy-aconitine were the major alcoholysates from diester alkaloids.
  
  
  CONCLUSIONS
  Pyraconitine alkaloids, as pyrolytic products, are not related to the type of solvent. 8-ethoxy-aconitine alkaloids, as alcoholysates, are related to the type of solvent. This study identifies multiple converted products from alkaloids and summarizes mass spectrometry fragmentation regularity by LC-MS, laying a firm foundation for studies on the transformation of toxic diester alkaloids contained in aconitum and providing a basis for studies on the transformation of alkaloids contained in aconitum during boiling.
authors.affiliation: China Pharmaceutical University, Nanjing 210009, China. wangff666@126.com
authors.forename: Fengfeng
authors.initials: F
authors.lastname: Wang
authors.forename: Zhaohui
authors.initials: Z
authors.lastname: Song
authors.forename: Lanlan
authors.initials: L
authors.lastname: Zhang
authors.forename: Shuiping
authors.initials: S
authors.lastname: Zhou
authors.forename: Feng
authors.initials: F
authors.lastname: Feng
mesh_terms: D031841:Aconitum / Q000737:chemistry*; D000470:Alkaloids / Q000737:chemistry*; D000431:Ethanol / Q000737:chemistry*; D006868:Hydrolysis; D013058:Mass Spectrometry
chemical_list: D000470:Alkaloids; D000431:Ethanol