title: Super-secondary structure: a historical perspective.
abstract: The history of the concept of protein folds is discussed, starting with the original concept of super-secondary structure. This has led to the recognition of a fairly small number of distinct folds defining individual domains within larger proteins. Each fold can usually be associated with a specific function. Thus the active site of an enzyme is likely to be at the boundary between domains, each contributing a simple function to a more complex process.
authors.affiliation: Department of Biological Sciences, Purdue University, West Lafayette, IN, USA. mr@purdue.edu
authors.forename: Michael G
authors.initials: MG
authors.lastname: Rossmann
mesh_terms: D049673:History, 20th Century; D008958:Models, Molecular; D017510:Protein Folding; D017433:Protein Structure, Secondary; D011506:Proteins / Q000737:chemistry / Q000266:history*
chemical_list: D011506:Proteins