title: Effects of a Pseudomonas aeruginosa eradication policy in a cystic fibrosis clinic.
abstract: OBJECTIVE
  This review is based upon the recent literature regarding eradication of newly acquired infection with Pseudomonas aeruginosa (Psa) in patients with cystic fibrosis (CF) and the economic and other effects of such an early eradication policy in a CF clinic.
  
  
  RESULTS
  Various Psa eradication protocols which utilize intravenous or aerosol anti-pseudomonal antibiotics, with or without oral antibiotics, have been reported. The recent ELITE trial reported successful eradication of 90% of Psa in selected Psa antibody negative patients after 28 days of tobramycin for inhalation. Another recent report of a protocol based on intravenous antibiotic use reported elimination of 'first growth' Psa in over 96% of all patients, accompanied by decreased chronic Psa infection, decreased anti-Psa treatment costs and decreased hospitalization costs.
  
  
  CONCLUSIONS
  The effects of early eradication protocols for Psa have included decreased prevalence of chronic Psa infection, improved patient health and pulmonary function, and decreased hospital and antibiotic costs.
authors.affiliation: Department of Pediatrics, Faculty of Medicine, University of British Columbia, and Cystic Fibrosis Clinic, BC Children's Hospital, Vancouver, British Columbia, Canada. GDavidson@cw.bc.ca
authors.forename: A George F
authors.initials: AG
authors.lastname: Davidson
authors.forename: Mark A
authors.initials: MA
authors.lastname: Chilvers
authors.forename: Yolanda P
authors.initials: YP
authors.lastname: Lillquist
mesh_terms: D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D003550:Cystic Fibrosis / Q000150:complications* / Q000191:economics; D060740:Disease Eradication; D006801:Humans; D011552:Pseudomonas Infections / Q000150:complications / Q000191:economics / Q000517:prevention & control*; D011550:Pseudomonas aeruginosa
chemical_list: D000900:Anti-Bacterial Agents