title: Comparison of Hb-200 and 6% hetastarch 450/0.7 during initial fluid resuscitation of 20 dogs with gastric dilatation-volvulus.
abstract: OBJECTIVE
  To compare the use of polymerized stroma-free bovine hemoglobin (Hb-200) and 6% hetastarch 450/0.7 (HES 450/0.7) in 0.9% saline during fluid resuscitation of dogs with gastric dilatation-volvulus (GDV).
  
  
  METHODS
  Prospective, randomized clinical case series.
  
  
  METHODS
  Private specialty and referral clinic.
  
  
  METHODS
  Twenty client-owned dogs presenting with GDV.
  
  
  METHODS
  Dogs presenting with GDV and abnormal perfusion parameters first received rapid IV infusion of a buffered isotonic replacement crystalloid (15 mL/kg) and IV opioids. Patients were then randomized to receive either Hb-200 (N = 10) or HES 450/0.7 (N = 10). Balanced isotonic replacement crystalloids (10-20 mL/kg IV) were rapidly infused along with either Hb-200 or HES in 5 mL/kg IV aliquots to meet resuscitation end points.
  
  
  RESULTS
  Resuscitation was defined as meeting at least 2 of 3 criteria: (1) capillary refill time 1-2 seconds, pink mucous membrane color, strong femoral pulse quality; (2) heart rate (HR) ≤ 150/min; or (3) indirect arterial systolic blood pressure (SBP) > 90 mm Hg. HR, SBP, packed cell volume, hemoglobin, glucose, venous pH, bicarbonate, base excess, anion gap, and colloid osmotic pressure were compared at hospital entry and within 30 minutes post-resuscitation. Compared to the HES group, the Hb-200 group required significantly less colloid (4.2 versus 18.4 mL/kg) and crystalloid (31.3 versus 48.1 mL/kg) to reach resuscitation end points (P = 0.001). Time to resuscitation was significantly shorter in the Hb-200 group (12.5 versus 52.5 min).
  
  
  CONCLUSIONS
  Dogs with GDV receiving Hb-200 during initial resuscitation required smaller volumes of both crystalloid and colloid fluids and reached resuscitation end points faster than dogs receiving HES 450/0.7 (P = 0.02).
authors.affiliation: Animal Emergency Center and Specialty Services, Silver Spring Drive, Glendale, WI, 53209, USA. caraol.haak@gmail.com
authors.forename: Carol E
authors.initials: CE
authors.lastname: Haak
authors.forename: Elke
authors.initials: E
authors.lastname: Rudloff
authors.forename: Rebecca
authors.initials: R
authors.lastname: Kirby
mesh_terms: D000818:Animals; D002417:Cattle; D004285:Dogs; D005260:Female; D005440:Fluid Therapy / Q000662:veterinary*; D013271:Gastric Dilatation / Q000628:therapy / Q000662:veterinary*; D006454:Hemoglobins / Q000008:administration & dosage*; D006895:Hydroxyethyl Starch Derivatives / Q000008:administration & dosage*; D008297:Male; D013277:Stomach Volvulus / Q000628:therapy / Q000662:veterinary*
chemical_list: D006454:Hemoglobins; D006895:Hydroxyethyl Starch Derivatives