title: Helical self-assembly of 2-(1,4,7,10-tetraazacyclododecan-1-yl)cyclohexan-1-ol (cycyclen).
abstract: The title macrocyclic amino alcohol compound, C(14)H(30)N(4)O, is investigated as a solid-state synthon for the design of a self-assembled tubular structure. It crystallizes in a helical column constructed by stereospecific O-H···N and N-H···N interactions. The hydrogen-bonding interactions, dependent upon macrocyclic ring helicity and molecular conformation, link R,R and S,S enantiomers in a head-to-tail fashion, forming a continuous hydrophilic inner core.
authors.affiliation: School of Chemistry, Molecular Sciences Institute, University of the Witwatersrand, Johannesburg, South Africa. alvaro.desousa@wits.ac.za
authors.forename: Alvaro S de
authors.initials: AS
authors.lastname: Sousa
authors.forename: Denzel
authors.initials: D
authors.lastname: Sannasy
authors.forename: Manuel A
authors.initials: MA
authors.lastname: Fernandes
authors.forename: Helder M
authors.initials: HM
authors.lastname: Marques