title: Comparative study of the cytotoxicity and genotoxicity of alpha- and Beta-asarone.
abstract: The cytotoxicity of alpha- and beta-asarone was investigated with the BrdU assay in HepG2-cells. Alpha-asarone was found to be more toxic than beta-asarone after 24 hours of treatment. Investigation of the genotoxicity using the micronucleus assay in the HepG2-cell system showed that only after metabolic activation by a liver microsomal preparation, beta-asarone was able to induce micronuclei at concentrations higher than 50 μg/mL.
authors.affiliation: Institut für Pharmazie, Freie Universität Berlin, Königin-Luise-Straße 2+4, D-14195 Berlin, Germany.
authors.forename: Pascal
authors.initials: P
authors.lastname: Unger
authors.forename: Matthias F
authors.initials: MF
authors.lastname: Melzig