title: Crotalariosis equorum ("jaagsiekte") in horses in southern Mozambique, a rare form of pyrrolizidine alkaloid poisoning.
abstract: Twenty-eight horses in southern Mozambique died after exhibiting severe respiratory distress. At necropsy, the overinflated lungs did not collapse, had prominent rib impressions, and were fibrotic and emphysematous. Microscopically, prominent proliferation of nonciliated epithelial (Clara) cells in the terminal bronchioles and pulmonary fibrosis were observed, indicative of chronic pneumotoxicity. Transmission electron microscopy demonstrated hyperplasia, desquamation, and apical bulging of Clara cells into the bronchiolar lumen. The outbreak was attributed to ingestion of Crotalaria dura J.M. Wood & M.S. Evans subsp. mozambica Polhill and Crotalaria monteiroi Taub. ex Baker f. var. monteiroi. Semiquantitative gas chromatography-mass spectrometry revealed the presence of pyrrolizidine alkaloids in these 2 Crotalaria species.
authors.affiliation: Department of Paraclinical Sciences, Faculty of VeterinaryScience, University of Pretoria, South Africa. christo.botha@up.ac.za
authors.forename: Christo J
authors.initials: CJ
authors.lastname: Botha
authors.forename: Alex
authors.initials: A
authors.lastname: Lewis
authors.forename: Elizabeth C
authors.initials: EC
authors.lastname: du Plessis
authors.forename: Sarah J
authors.initials: SJ
authors.lastname: Clift
authors.forename: Mark C
authors.initials: MC
authors.lastname: Williams
mesh_terms: D000818:Animals; D029864:Crotalaria / Q000737:chemistry / Q000633:toxicity*; D006734:Horse Diseases / Q000139:chemically induced*; D006736:Horses; D008168:Lung / Q000648:ultrastructure; D008171:Lung Diseases / Q000139:chemically induced / Q000473:pathology / Q000662:veterinary*; D009073:Mozambique / Q000453:epidemiology; D010939:Plant Poisoning / Q000662:veterinary*; D011763:Pyrrolizidine Alkaloids / Q000737:chemistry / Q000506:poisoning*
chemical_list: D011763:Pyrrolizidine Alkaloids