title: CC chemokine receptor 5 polymorphism in Italian patients with giant cell arteritis.
abstract: OBJECTIVE
  To evaluate the potential role of CC chemokine receptor 5 (CCR5)Δ32 polymorphism in the susceptibility to giant cell arteritis (GCA) in a cohort of Italian patients.
  
  
  METHODS
  176 consecutive Italian patients with biopsy-proven GCA and 180 healthy age- and sex-matched blood donors were molecularly genotyped for the CCR5Δ32 polymorphism.
  
  
  RESULTS
  No statistically significant difference in the Δ32CCR5 allele frequency between GCA patients (5.1 %) and controls (2.8 %) was observed (p = 0.109). Carriers of the CCR5Δ32 allele (Δ32/Δ32 + CCR5/Δ32) were similarly represented in the two groups.
  
  
  CONCLUSIONS
  Our results do not support a role for the CCR5Δ32 polymorphism in determining susceptibility to GCA.
authors.affiliation: Rheumatology Unit, Department of Internal Medicine, Azienda Ospedaliera Arcispedale S Maria Nuova, Istituto di Ricovero e Cura a Carattere Scientifico, Viale Risorgimento n 80, 42100, Reggio Emilia, Italy.
authors.forename: Giulia
authors.initials: G
authors.lastname: Pazzola
authors.forename: Luigi
authors.initials: L
authors.lastname: Boiardi
authors.forename: Bruno
authors.initials: B
authors.lastname: Casali
authors.forename: Enrico
authors.initials: E
authors.lastname: Farnetti
authors.forename: Davide
authors.initials: D
authors.lastname: Nicoli
authors.forename: Nicolò
authors.initials: N
authors.lastname: Pipitone
authors.forename: Ilaria
authors.initials: I
authors.lastname: Padovano
authors.forename: Andrea
authors.initials: A
authors.lastname: Caruso
authors.forename: Mariagrazia
authors.initials: M
authors.lastname: Catanoso
authors.forename: Carlo
authors.initials: C
authors.lastname: Salvarani
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000483:Alleles; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D013700:Giant Cell Arteritis / Q000235:genetics*; D006801:Humans; D007558:Italy; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic; D019713:Receptors, CCR5 / Q000235:genetics*
chemical_list: D019713:Receptors, CCR5