title: [Influence of сycloferon on the сytokine blood profile and production of proinflammatory сytokines in the cultures of mononucleares of peripheral blood of the patients with chronic tonsillitis].
abstract: The 88 patients with chronic tonsillitis (CT) was investigated. The 46 patients (basic group) got the modern immunoactive preparation cycloferon and 42 patients (comparison group) - only the generally accepted therapy. During immunological researches on a background clinical manifestation of СT the increase proinflammatory cytokines (CK) (TNFα, IL-1Β) in the serum, and also increase the level of spontaneous products of these CK in the cultures mononucleares of periferal blood was detected. At general accepted treatment took place increase level proinflammatory CK at serum on background decline stimulated product of CK at mononucleares cultures. Aрplication of cycloferon at the treatment of CT provided to normalization cytokines profile of the blood and production of CK in the cultures mononucleares.
authors.forename: V R
authors.initials: VR
authors.lastname: Demenkov
authors.forename: V M
authors.initials: VM
authors.lastname: Frolov
authors.forename: N A
authors.initials: NA
authors.lastname: Peresadin
authors.forename: O V
authors.initials: OV
authors.lastname: Kruglova
mesh_terms: D000166:Acridines / Q000008:administration & dosage / Q000493:pharmacokinetics; D000328:Adult; D001682:Biological Availability; D002908:Chronic Disease; D016207:Cytokines / Q000097:blood*; D005260:Female; D006801:Humans; D056747:Immunomodulation / Q000187:drug effects*; D007369:Interferon Inducers / Q000008:administration & dosage / Q000493:pharmacokinetics; D008297:Male; D008875:Middle Aged; D015166:Monitoring, Immunologic / Q000379:methods; D014069:Tonsillitis / Q000097:blood / Q000276:immunology / Q000503:physiopathology / Q000628:therapy; D016896:Treatment Outcome
chemical_list: D000166:Acridines; D016207:Cytokines; D007369:Interferon Inducers; C026430:10-carboxymethyl-9-acridanone