title: Coordination polymer coated mesoporous silica nanoparticles for pH-responsive drug release.
abstract: Coordination polymer coated mesoporous silica nanoparticles for drug delivery are successfully synthesized. The system ensures that drugs are stored in the mesopores under a physiological environment. Upon H(+)  stimulus in the endosomal and lysosomal compartments, the drugs are released into the intracellular organelles of cancer cells, effectively killing the cells.
authors.affiliation: School of Chemistry and Chemical Engineering, State Key Laboratory Metal Matrix Composites, Key Laboratory for Thin Film and Microfabrication Technology of the Ministry of Education, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai 200240, China.
authors.forename: Lei
authors.initials: L
authors.lastname: Xing
authors.forename: Haoquan
authors.initials: H
authors.lastname: Zheng
authors.forename: Yuanyuan
authors.initials: Y
authors.lastname: Cao
authors.forename: Shunai
authors.initials: S
authors.lastname: Che
mesh_terms: D016503:Drug Delivery Systems; D006863:Hydrogen-Ion Concentration; D053758:Nanoparticles / Q000737:chemistry*; D010316:Particle Size; D011108:Polymers / Q000138:chemical synthesis / Q000737:chemistry*; D016062:Porosity; D012822:Silicon Dioxide / Q000737:chemistry*; D013499:Surface Properties; D019772:Topotecan / Q000737:chemistry*
chemical_list: D011108:Polymers; D012822:Silicon Dioxide; D019772:Topotecan