title: Biochemical lung, liver and kidney markers and early death among elderly following hip fracture.
abstract: BACKGROUND
  In the elderly, hip fracture is a common injury associated with high early mortality dominated by cardiorespiratory and thromboembolic events. Identification of risk factors that can be modified by treatment has caught attention over the last years. This study was conducted to assess biological markers on perioperative organ dysfunction and its association with early mortality within 3 months after surgery.
  
  
  METHODS
  Blood samples were collected before, during and until 4 days after surgery. Analyses on PaO(2), alanine aminotransaminase (ALAT), gamma-glutamyl transpeptidase (g-GT) and creatinine were performed and used as markers on lung, liver and kidney functions.
  
  
  METHODS
  Three hundred and two patients over 75 years of age with acute dislocated hip fracture were consecutively enrolled from two hospitals in Norway.
  
  
  RESULTS
  We found a positive correlation between the plasma levels of ALAT, creatinine and death, and an inverse relationship between PaO(2) and death. After controlling for confounding factors such as sex, age and comorbidity, ALAT and creatinine levels were shown to be significantly and independently related to risk for fatal outcome.
  
  
  CONCLUSIONS
  Our results provide data on clinically important biomarkers in patients undergoing hip fracture surgery. We suggest a stronger emphasis on monitoring and correcting these biomarkers when possible.
authors.affiliation: Department of Orthopaedics, Sykehuset Innlandet Hospital Trust, Elverum, Norway. ove.talsnes@sykehuset-innlandet.no
authors.forename: Ove
authors.initials: O
authors.lastname: Talsnes
authors.forename: Fredrik
authors.initials: F
authors.lastname: Hjelmstedt
authors.forename: Ola E
authors.initials: OE
authors.lastname: Dahl
authors.forename: Are Hugo
authors.initials: AH
authors.lastname: Pripp
authors.forename: Olav
authors.initials: O
authors.lastname: Reikerås
mesh_terms: D000368:Aged; D000410:Alanine Transaminase / Q000097:blood; D015415:Biomarkers / Q000097:blood; D001784:Blood Gas Analysis; D003404:Creatinine / Q000097:blood; D005260:Female; D006620:Hip Fractures / Q000097:blood* / Q000378:metabolism / Q000401:mortality*; D006801:Humans; D007668:Kidney / Q000378:metabolism*; D008099:Liver / Q000378:metabolism*; D008168:Lung / Q000503:physiopathology*; D008297:Male; D011446:Prospective Studies; D013997:Time Factors; D005723:gamma-Glutamyltransferase / Q000097:blood
chemical_list: D015415:Biomarkers; D003404:Creatinine; D005723:gamma-Glutamyltransferase; D000410:Alanine Transaminase