title: Thermosensitive poly(N-isopropylacrylamide-co-glycidyl methacrylate) microgels for controlled drug release.
abstract: A new type of thermosensitive microgels with epoxy functional groups is designed and synthesized for drug delivery. The thermosensitive poly(N-isopropylacrylamide-co-glycidyl methacrylate) (designated as P(NIPAM-co-GMA)) microgels are prepared by an emulsifier-free emulsion polymerization method and the chemical composition of the copolymer is determined by Fourier transform infrared spectroscopy (FTIR) and nuclear magnetic resonance ((1)H NMR). The lower critical solution temperature (LCST) of the microgels is 32°C based on the transmittance changes at 500 nm monitored by UV/visible spectrophotometry. The hydrodynamic diameter and morphology of the microgel particles are examined by dynamic light scattering (DLS) and scanning electron microscopy (SEM), respectively. The drug release properties determined using 5-FU as the drug model in vitro reveal temperature dependence and low cytotoxicity. The thermosensitive microgels have large potential as targeted anti-cancer drug carriers.
authors.affiliation: Department of Physics and Materials Science, City University of Hong Kong, Kowloon, Hong Kong, China.
authors.forename: Penghui
authors.initials: P
authors.lastname: Li
authors.forename: Ruizhen
authors.initials: R
authors.lastname: Xu
authors.forename: Wenhao
authors.initials: W
authors.lastname: Wang
authors.forename: Xiaolong
authors.initials: X
authors.lastname: Li
authors.forename: Zushun
authors.initials: Z
authors.lastname: Xu
authors.forename: Kelvin W K
authors.initials: KW
authors.lastname: Yeung
authors.forename: Paul K
authors.initials: PK
authors.lastname: Chu
mesh_terms: D016475:3T3 Cells; D000465:Algorithms; D000818:Animals; D000964:Antimetabolites, Antineoplastic / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology; D002470:Cell Survival / Q000187:drug effects; D003692:Delayed-Action Preparations; D016503:Drug Delivery Systems; D004655:Emulsions; D004852:Epoxy Compounds / Q000737:chemistry; D005079:Excipients / Q000737:chemistry*; D005472:Fluorouracil / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology; D005782:Gels; D008027:Light; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D008855:Microscopy, Electron, Scanning; D010006:Osteoblasts / Q000187:drug effects; D011109:Polymethacrylic Acids / Q000737:chemistry*; D012542:Scattering, Radiation; D013056:Spectrophotometry, Ultraviolet; D017550:Spectroscopy, Fourier Transform Infrared; D013696:Temperature
chemical_list: D000964:Antimetabolites, Antineoplastic; D003692:Delayed-Action Preparations; D004655:Emulsions; D004852:Epoxy Compounds; D005079:Excipients; D005782:Gels; D011109:Polymethacrylic Acids; C580938:poly(N-isopropylacrylamide-co-glycidyl methacrylate); D005472:Fluorouracil