title: Enteroviruses isolated from herpangina and hand-foot-and-mouth disease in Korean children.
abstract: Hand-foot-and-mouth disease (HFMD) and herpangina are commonly prevalent illness in young children. They are similarly characterized by lesions on the skin and oral mucosa. Both diseases are associated with various enterovirus serotypes. In this study, enteroviruses from patients with these diseases in Korea in 2009 were isolated and analyzed. Demographic data for patients with HFMD and herpangina were compared and all enterovirus isolates were amplified in the VP1 region by reverse transcription-polymerase chain reaction and sequenced. Among the enterovirus isolates, prevalent agents were coxsackievirus A16 in HFMD and coxsackievirus A5 in herpangina. More prevalent months for HFMD were June (69.2%) and May (11.5%), and June (40.0%) and July (24.0%) for herpangina. Age prevalence of HFMD patients with enterovirus infection was 1 year (23.1%), 4 years (19.2%), and over 5 years (19.2%). However, the dominant age group of herpangina patients with enterovirus infection was 1 year (48.0%) followed by 2 years (28.0%). Comparison of pairwise VP1 nucleotide sequence alignment of all isolates within the same serotypes revealed high intra-type variation of CVA2 isolates (84.6-99.3% nucleotide identity). HFMD and herpangina showed differences in demographic data and serotypes of isolated enteroviruses, but there was no notable difference in amino acid sequences by clinical syndromes in multiple comparison of the partial VP1 gene sequence.
authors.affiliation: Department of Clinical Pathology, Daejeon Health Sciences College, Daejeon, South Korea.
authors.forename: KwiSung
authors.initials: K
authors.lastname: Park
authors.forename: BaeckHee
authors.initials: B
authors.lastname: Lee
authors.forename: KyoungAh
authors.initials: K
authors.lastname: Baek
authors.forename: DooSung
authors.initials: D
authors.lastname: Cheon
authors.forename: SangGu
authors.initials: S
authors.lastname: Yeo
authors.forename: JoonSoo
authors.initials: J
authors.lastname: Park
authors.forename: JaeWan
authors.initials: J
authors.lastname: Soh
authors.forename: HaeKyung
authors.initials: H
authors.lastname: Cheon
authors.forename: KyungAh
authors.initials: K
authors.lastname: Yoon
authors.forename: YoungJin
authors.initials: Y
authors.lastname: Choi
mesh_terms: D017677:Age Distribution; D044466:Asian People; D002648:Child; D002675:Child, Preschool; D004770:Enterovirus / Q000302:isolation & purification*; D005260:Female; D014644:Genetic Variation; D006232:Hand, Foot and Mouth Disease / Q000453:epidemiology / Q000821:virology*; D006557:Herpangina / Q000453:epidemiology / Q000821:virology*; D006801:Humans; D007223:Infant; D008297:Male; D017720:Molecular Epidemiology; D008969:Molecular Sequence Data; D015995:Prevalence; D012367:RNA, Viral / Q000235:genetics; D056910:Republic of Korea / Q000453:epidemiology; D020133:Reverse Transcriptase Polymerase Chain Reaction; D017422:Sequence Analysis, DNA; D015678:Viral Structural Proteins / Q000235:genetics
chemical_list: D012367:RNA, Viral; D015678:Viral Structural Proteins