title: Neurologic manifestations of Fusobacterium infections in children.
abstract: Fusobacterium necrophorum causes various clinical syndromes, ranging from otitis media to life-threatening Lemierre's syndrome. The purpose of this study was to review our experience with pediatric Fusobacterium infections. The medical records of all children aged 0 to 18 years who were diagnosed between 1999 and 2011 with Fusobacterium infection were reviewed. Fusobacterium was isolated from clinical samples of 27 children: blood cultures (n = 16), abscesses (n = 8), joint fluids (n = 2), and cerebrospinal fluid (n = 1). The median age at admission was 3.5 years (range, 7 months to 17 years). Eight children (30 %) had seizures at presentation. Ten children (37 %) underwent lumbar puncture. Fifteen children (56 %) underwent brain imaging, and in seven of these children, a thrombus was identified either in a sinus vein or in an internal jugular vein. The most common source of infection was otogenic in 19 (70 %) of the children. Six of the children presented in 2011. All patients recovered.
  
  
  CONCLUSIONS
  Neurologic manifestations are common at presentation of children with Fusobacterium infections. In young children, the most common source of infection is otogenic. Thrombotic complications are common, and imaging should be considered in all children with Fusobacterium infections arising from the head or neck region. There was a recent increase in the isolation of this bacterium, either because of better culturing techniques and increased awareness to this entity or a true increase in infections due to this organism.
authors.affiliation: Pediatric Department and Pediatric Infectious Diseases Unit, Shaare Zedek Medical Center, Hadassah-Hebrew University Medical School, P.O.B. 3235, Jerusalem, Israel. orlimegged@yahoo.com
authors.forename: Orli
authors.initials: O
authors.lastname: Megged
authors.forename: Marc V
authors.initials: MV
authors.lastname: Assous
authors.forename: Hagit
authors.initials: H
authors.lastname: Miskin
authors.forename: Uri
authors.initials: U
authors.lastname: Peleg
authors.forename: Yechiel
authors.initials: Y
authors.lastname: Schlesinger
mesh_terms: D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D005260:Female; D005674:Fusobacterium Infections / Q000150:complications / Q000175:diagnosis*; D005675:Fusobacterium necrophorum / Q000302:isolation & purification*; D006801:Humans; D007223:Infant; D008297:Male; D009422:Nervous System Diseases / Q000175:diagnosis* / Q000382:microbiology