title: Association between XPD Asp312Asn polymorphism and esophageal cancer susceptibility: a meta-analysis.
abstract: OBJECTIVE
  To investigate the association between xeroderma pigmentosum group D (XPD) Asp312Asn polymorphism and esophageal cancer (EC) susceptibility by meta-analysis.
  
  
  METHODS
  We searched PubMed up to April 9th, 2012, to identify relevant papers, and 8 published case-control studies including 2165 EC patients and 3141 healthy controls were yielded. Odds ratios (ORs) with relevant 95% confidence intervals (CIs) were applied to assess the association between XPD Asp312Asn polymorphism and EC susceptibility with the Comprehensive Meta-Analysis software, version 2.2.
  
  
  RESULTS
  Overall, the meta-analysis results suggested the XPD Asp312Asn polymorphism to be significantly associated with EC susceptibility [(Asn/Asn+Asp/Asn) vs. Asp/Asp: OR=1.20, 95%CI=1.05-1.36, p=0.01; and Asp/Asn vs. Asp/Asp: OR=1.15, 95%CI=1.01-1.31, p=0.04]. In the subgroup analysis by ethnicity and cancer type, significantly associations were found for Caucasian populations [(Asn/Asn+Asp/Asn) vs. Asp/Asp: OR=1.26, 95%CI=1.08-1.47, p<0.001; Asp/Asn vs. Asp/Asp: OR=1.19, 95%CI=1.02- 1.40, p=0.03] and esophageal squamous cell carcinoma [(Asn/Asn+Asp/Asn) vs. Asp/Asp: OR=1.19, 95%CI=1.01-1.41, p=0.04]. There was no heterogeneity and no publication bias existed.
  
  
  CONCLUSIONS
  This meta-analysis shows that the XPD Asp312Asn polymorphism may be a risk factor for developing EC, especially for Caucasian populations and esophageal squamous cell carcinoma.
authors.affiliation: Department of Digestion Medcine, Taihe Hospital, Hubei University of Medcine, Shiyan, Hubei Province, China.
authors.forename: Xiao-Li
authors.initials: XL
authors.lastname: Duan
authors.forename: Heng
authors.initials: H
authors.lastname: Gong
authors.forename: Xian-Tao
authors.initials: XT
authors.lastname: Zeng
authors.forename: Xiao-Bing
authors.initials: XB
authors.lastname: Ni
authors.forename: Yan
authors.initials: Y
authors.lastname: Yan
authors.forename: Wen
authors.initials: W
authors.lastname: Chen
authors.forename: Guo-Lei
authors.initials: GL
authors.lastname: Liu
mesh_terms: D002294:Carcinoma, Squamous Cell / Q000235:genetics; D016022:Case-Control Studies; D004938:Esophageal Neoplasms / Q000235:genetics*; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D016017:Odds Ratio; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors; D044465:White People / Q000235:genetics; D051759:Xeroderma Pigmentosum Group D Protein / Q000235:genetics*
chemical_list: D051759:Xeroderma Pigmentosum Group D Protein; C497292:ERCC2 protein, human