title: Aerobic oxidative amidation of aromatic and cinnamic aldehydes with secondary amines by CuI/2-pyridonate catalytic system.
abstract: A simple and convenient CuI/2-pyridonate catalytic system for the oxidative amidation of aldehydes with secondary amines has been developed. With this system, a variety of useful arylamides have been synthesized in moderate to good yields in the presence of small amount of copper catalyst and the pyridonate ligand, generating only water as a coproduct. Synthesis of cinnamamides was also achieved by the reactions of cinnamaldehydes with secondary amines in moderate yields. Air was successfully employed as a green oxidant in this catalytic system, achieving a safe and atom-efficient system for the synthesis of amides.
authors.affiliation: Graduate School of Human and Environmental Studies, Kyoto University, Sakyo-ku, Kyoto 606-8501, Japan.
authors.forename: Mingwen
authors.initials: M
authors.lastname: Zhu
authors.forename: Ken-ichi
authors.initials: K
authors.lastname: Fujita
authors.forename: Ryohei
authors.initials: R
authors.lastname: Yamaguchi
mesh_terms: D000447:Aldehydes / Q000737:chemistry*; D000577:Amides / Q000138:chemical synthesis* / Q000737:chemistry; D000588:Amines / Q000737:chemistry*; D002384:Catalysis; D003300:Copper / Q000737:chemistry*; D007454:Iodides / Q000737:chemistry*; D015394:Molecular Structure; D010084:Oxidation-Reduction; D011728:Pyridones / Q000737:chemistry*
chemical_list: D000447:Aldehydes; D000577:Amides; D000588:Amines; D007454:Iodides; D011728:Pyridones; D003300:Copper; C073870:cuprous iodide