title: Nephro-protective effect of vitamin C and Nigella sativa oil on gentamicin associated nephrotoxicity in rabbits.
abstract: Oxidative stress causes the generation of reactive oxygen species (ROS) that lead to nephrotoxicity. An aminoglycoside, gentamicin, has pronounced nephrotoxic effect in humans and animals and this study was planned to observe the nephro-protective effect of antioxidants, vitamin C and Nigella sativa oil. Serum creatinine, blood urea nitrogen, and antioxidant activity were measured as indicators of nephrotoxicity for all the groups of rabbits. Results showed that vitamin C and Nigella sativa oil both had nephro-protective effect as they lowered the values of nephrotoxicity indicators (serum creatinine, blood urea nitrogen, and antioxidant activity) as compared to gentamicin control group values. When these two antioxidants were given as combination, they proved to have synergistic nephro-protective effect.
authors.affiliation: College of Pharmacy, Govt. College University, Faisalabad, Pakistan. uzma95@gmail.com
authors.forename: Uzma
authors.initials: U
authors.lastname: Saleem
authors.forename: Bashir
authors.initials: B
authors.lastname: Ahmad
authors.forename: Kanwal
authors.initials: K
authors.lastname: Rehman
authors.forename: Saeed
authors.initials: S
authors.lastname: Mahmood
authors.forename: Maqsood
authors.initials: M
authors.lastname: Alam
authors.forename: Alia
authors.initials: A
authors.lastname: Erum
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D001205:Ascorbic Acid / Q000494:pharmacology*; D015415:Biomarkers / Q000097:blood; D001806:Blood Urea Nitrogen; D003404:Creatinine / Q000097:blood; D019610:Cytoprotection; D004195:Disease Models, Animal; D004357:Drug Synergism; D004359:Drug Therapy, Combination; D005839:Gentamicins; D007674:Kidney Diseases / Q000139:chemically induced / Q000378:metabolism / Q000517:prevention & control*; D008297:Male; D009399:Nephrons / Q000187:drug effects* / Q000378:metabolism; D018384:Oxidative Stress / Q000187:drug effects*; D010938:Plant Oils / Q000494:pharmacology*; D011817:Rabbits; D013997:Time Factors; D029974:Carum
chemical_list: D000975:Antioxidants; D015415:Biomarkers; D005839:Gentamicins; D010938:Plant Oils; D003404:Creatinine; C104525:caraway oil; D001205:Ascorbic Acid