title: Ring-closing metathesis/isomerization/Pictet-Spengler cascade via ruthenium/chiral phosphoric acid sequential catalysis.
abstract: Chiral phosphoric acid worked together with Hoveyda-Grubbs II catalyst enabling highly efficient synthesis of enantioenriched tetrahydro-β-carbolines (up to 98% yield, 99% ee) through a ring-closing metathesis/isomerization/Pictet-Spengler cascade reaction via sequential catalysis.
authors.affiliation: State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Lu, Shanghai 200032, China.
authors.forename: Quan
authors.initials: Q
authors.lastname: Cai
authors.forename: Xiao-Wei
authors.initials: XW
authors.lastname: Liang
authors.forename: Shou-Guo
authors.initials: SG
authors.lastname: Wang
authors.forename: Jun-Wei
authors.initials: JW
authors.lastname: Zhang
authors.forename: Xiao
authors.initials: X
authors.lastname: Zhang
authors.forename: Shu-Li
authors.initials: SL
authors.lastname: You
mesh_terms: D002384:Catalysis; D015394:Molecular Structure; D010756:Phosphoric Acids / Q000737:chemistry*; D012428:Ruthenium / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D010756:Phosphoric Acids; D012428:Ruthenium; C030242:phosphoric acid