title: Two pregnane derivatives and a quinolone alkaloid from Helicteres angustifolia.
abstract: Phytochemical investigation of the ethanol extract from roots of Helicteres angustifolia led to the isolation of two new pregnane derivatives, heligenin A-B (1-2), and a new quinolone alkaloid, helicterone A (3), along with thirteen known compounds (4-16). The structures of new compounds were established by analysis of extensive spectroscopic data. The absolute configuration of 1 was determined by application of the modified Mosher's method. All of the isolates were evaluated for their anti-proliferative activities against HT-29 human colon cancer cells and OVCA 429 ovarian cancer cells by MTT assay.
authors.affiliation: Institute of Traditional Chinese Medicine and Natural Products, College of Pharmacy, Jinan University, Guangzhou, 510632, PR China.
authors.forename: Guo-Cai
authors.initials: GC
authors.lastname: Wang
authors.forename: Tao
authors.initials: T
authors.lastname: Li
authors.forename: Ying-Rou
authors.initials: YR
authors.lastname: Wei
authors.forename: Yan-Bo
authors.initials: YB
authors.lastname: Zhang
authors.forename: Yao-Lan
authors.initials: YL
authors.lastname: Li
authors.forename: Stephen Cho Wing
authors.initials: SC
authors.lastname: Sze
authors.forename: Wen-Cai
authors.initials: WC
authors.lastname: Ye
mesh_terms: D000470:Alkaloids / Q000737:chemistry*; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000494:pharmacology; D045744:Cell Line, Tumor; D006801:Humans; D019660:Malvaceae / Q000737:chemistry*; D015394:Molecular Structure; D018517:Plant Roots / Q000737:chemistry; D011278:Pregnanes / Q000737:chemistry*; D015363:Quinolones / Q000737:chemistry*
chemical_list: D000470:Alkaloids; D000972:Antineoplastic Agents, Phytogenic; D011278:Pregnanes; D015363:Quinolones