title: AlCl3 mediated unexpected migration of sulfonyl groups: regioselective synthesis of 7-sulfonyl indoles of potential pharmacological interest.
abstract: A conceptually new and straightforward introduction of sulfonyl groups at the C-7 position of an indole ring has been achieved via AlCl(3) mediated unexpected regioselective sulfonyl group migration for N-alkyl/aryl/heteroarylsulfonyl indoles affording potential inhibitors of Mycobacterium tuberculosis H37Rv chorismate mutase.
authors.affiliation: Institute of Life Sciences, University of Hyderabad Campus, Gachibowli, Hyderabad 500 046, India.
authors.forename: Bagineni
authors.initials: B
authors.lastname: Prasad
authors.forename: Raju
authors.initials: R
authors.lastname: Adepu
authors.forename: Sandhya
authors.initials: S
authors.lastname: Sandra
authors.forename: D
authors.initials: D
authors.lastname: Rambabu
authors.forename: G Rama
authors.initials: GR
authors.lastname: Krishna
authors.forename: C Malla
authors.initials: CM
authors.lastname: Reddy
authors.forename: Girdhar Singh
authors.initials: GS
authors.lastname: Deora
authors.forename: Parimal
authors.initials: P
authors.lastname: Misra
authors.forename: Manojit
authors.initials: M
authors.lastname: Pal
mesh_terms: D000077410:Aluminum Chloride; D017607:Aluminum Compounds / Q000737:chemistry*; D002712:Chlorides / Q000737:chemistry*; D002826:Chorismate Mutase / Q000037:antagonists & inhibitors* / Q000378:metabolism; D018360:Crystallography, X-Ray; D004791:Enzyme Inhibitors / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D007211:Indoles / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D008958:Models, Molecular; D015394:Molecular Structure; D009169:Mycobacterium tuberculosis / Q000201:enzymology*; D013237:Stereoisomerism; D013329:Structure-Activity Relationship; D013450:Sulfones / Q000737:chemistry*
chemical_list: D017607:Aluminum Compounds; D002712:Chlorides; D004791:Enzyme Inhibitors; D007211:Indoles; D013450:Sulfones; D000077410:Aluminum Chloride; D002826:Chorismate Mutase