title: Neurolymphomatosis diagnosed by (18)F-FDG PET-CT.
abstract: Neurolymphomatosis is defined as infiltration of the nervous system by hematological malignancy and is difficult to diagnose. We report a case of a 57-year-old man, treated for small B-cell non-Hodgkin lymphoma, presenting with sensorimotor impairment of the lower limbs, which started 6 years after diagnosis. He was treated with chemotherapy, after which, the symptoms disappeared. After 7 months, he developed sensorimotor impairment of both upper limbs. MRI of the brachial plexus showed no abnormalities. F-FDG PET-CT showed increased uptake at the brachial plexus and nerves, suggesting neurolymphomatosis. Confirmatory biopsy revealed conversion of the malignancy to diffuse large B-cell lymphoma.
authors.affiliation: Department of Nuclear Medicine, Leiden University Medical Center, Leiden, The Netherlands.
authors.forename: Liesbeth P
authors.initials: LP
authors.lastname: Salm
authors.forename: Bernies
authors.initials: B
authors.lastname: Van der Hiel
authors.forename: Marcel P M
authors.initials: MP
authors.lastname: Stokkel
mesh_terms: D044963:Biopsy, Fine-Needle; D019788:Fluorodeoxyglucose F18; D006801:Humans; D016393:Lymphoma, B-Cell / Q000175:diagnosis* / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D064847:Multimodal Imaging; D009423:Nervous System Neoplasms / Q000175:diagnosis* / Q000473:pathology*; D011877:Radionuclide Imaging
chemical_list: D019788:Fluorodeoxyglucose F18