title: Anti-microbial activities of sulfonamides using disc diffusion method.
abstract: Sulfonamides, being the member of the oldest anti-microbial group of compounds possess wide anti-microbial activities and are effective against pathogenic strains of gram-positive and gram-negative bacteria. They are widely used in the treatment of various infectious diseases e.g. malaria, urinary tract infections, respiratory tract infections etc. Based on their effectiveness against most of the bacteria, two novel sulfonamides (N-(2-methoxy phenyl)-4-methylbenzenesulfonamide and N-ethyl-4-methyl-N-(3-methyl phenyl)benzenesulfonamide) were synthesized. The compounds were characterized by FT-IR and elemental analyzer. Their anti-microbial activity was assessed and observed against gram-positive and gram-negative bacteria using disc diffusion method. They showed good anti-microbial activities.
authors.affiliation: Department of Chemistry, Government College University Lahore, Lahore, Pakistan.
authors.forename: Saba
authors.initials: S
authors.lastname: Ahmad
authors.forename: Muhammad Akhyar
authors.initials: MA
authors.lastname: Farrukh
mesh_terms: D000890:Anti-Infective Agents / Q000138:chemical synthesis / Q000494:pharmacology*; D018360:Crystallography, X-Ray; D052978:Disk Diffusion Antimicrobial Tests; D006090:Gram-Negative Bacteria / Q000187:drug effects / Q000254:growth & development; D006094:Gram-Positive Bacteria / Q000187:drug effects / Q000254:growth & development; D015394:Molecular Structure; D017550:Spectroscopy, Fourier Transform Infrared; D013449:Sulfonamides / Q000138:chemical synthesis / Q000494:pharmacology*
chemical_list: D000890:Anti-Infective Agents; D013449:Sulfonamides