title: "Quasi-symmetric" FDG avidity of bilateral salivary glands in Mikulicz disease yielding false-positive staging in lung cancer.
abstract: A 77-year-old man with lung cancer underwent fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT). Cervical FDG uptake of variable intensity was detected corresponding to enlarged masses in the bilateral parotid and left submandibular regions. We suspected metastases from primary lung cancer or coexisting salivary gland neoplasms. Histopathological examination of the FDG-avid parotid mass revealed Mikulicz disease, an uncommon autoimmune disease involving the salivary glands. We present this case of Mikulicz disease with "quasi-symmetric" FDG avidity in the major salivary glands. We believe that salivary FDG uptake can lead to erroneous interpretation of tumor staging using PET.
authors.affiliation: PET Center and Department of Nuclear Medicine, Tri-Service General Hospital & National Defense Medical Center, 325, Cheng-Kung Road, Sec. 2, Taipei, Taiwan, Republic of China.
authors.forename: Li-Fan
authors.initials: LF
authors.lastname: Lin
authors.forename: Daniel Hy
authors.initials: DH
authors.lastname: Shen
authors.forename: Wen-Chiuan
authors.initials: WC
authors.lastname: Tsai
authors.forename: Cheng-Han
authors.initials: CH
authors.lastname: Hou
authors.forename: Cheng-Yi
authors.initials: CY
authors.lastname: Cheng
authors.forename: Ching-Yuan
authors.initials: CY
authors.lastname: Chen
mesh_terms: D000368:Aged; D005189:False Positive Reactions; D019788:Fluorodeoxyglucose F18; D006801:Humans; D008175:Lung Neoplasms / Q000150:complications / Q000000981:diagnostic imaging* / Q000473:pathology*; D008297:Male; D008882:Mikulicz' Disease / Q000150:complications / Q000000981:diagnostic imaging* / Q000473:pathology; D064847:Multimodal Imaging; D009367:Neoplasm Staging; D049268:Positron-Emission Tomography; D012469:Salivary Glands / Q000000981:diagnostic imaging* / Q000473:pathology; D014057:Tomography, X-Ray Computed
chemical_list: D019788:Fluorodeoxyglucose F18