title: [The association between beta-adrenergic receptor gene polymorphisms and personality traits].
abstract: The relationship between the polymorphisms (SNPs) of the beta-adrenergic receptor (beta-AR) gene and personality assessed by TCI (Temperament and Character Inventory), was studied among 192 healthy Japanese subjects (121 male subjects and 71 female subjects). In this study, the statistical analyses were performed overall and separately for each sex. As a result, it was shown that there were significant relationships between SD (self-directedness) and 49Ser/Gly (rs1801252) in ADRB1, P (persistence) and 389Arg/Gly (rs1801253) in ADRB1, and ST (self-transcendence) and 27Gln/Glu (rs1042714) in ADRB2 overall. Among the male subjects, there were further significant relationships between ST and 49Ser/Gly in ADRB1, NS (novelty-seeking), HA (harm avoidance) and P and 389Arg/Gly in ADRB1, and P and 64Arg/Trp(rsrs4994) in ADRB3. Among the female subjects, there were also significant relationships between SD and 49Ser/Gly in ADRB1, and C (cooperativeness) and 389Arg/Gly in ADRB1. Thus it was shown that there were correlations between beta-AR gene polymorphisms and several subscales of TCI.
authors.affiliation: Laboratory of Neurophysiology the Graduate School of Environmental Health Sciences Azabu University, 1-17-71 Fuchinobe, Chuo-ku, Sagamihara, 252-5201 Japan.
authors.forename: Maki
authors.initials: M
authors.lastname: Numajiri
authors.forename: Jun
authors.initials: J
authors.lastname: Aoki
authors.forename: Daisuke
authors.initials: D
authors.lastname: Nishizawa
authors.forename: Shinya
authors.initials: S
authors.lastname: Kasai
authors.forename: Yasukazu
authors.initials: Y
authors.lastname: Ogai
authors.forename: Kazutaka
authors.initials: K
authors.lastname: Ikeda
authors.forename: Kazuhiko
authors.initials: K
authors.lastname: Iwahashi
mesh_terms: D000328:Adult; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010551:Personality / Q000235:genetics*; D010554:Personality Disorders / Q000235:genetics*; D011110:Polymorphism, Genetic / Q000235:genetics*; D011943:Receptors, Adrenergic, beta / Q000235:genetics*; D013694:Temperament / Q000502:physiology*; D055815:Young Adult
chemical_list: D011943:Receptors, Adrenergic, beta