title: Aminoglycoside antibiotics bind to the influenza A virus RNA promoter.
abstract: Aminoglycosides bind to the influenza A virus promoter (vRNA) at submicromolar concentration. The complex structure between the vRNA and neomycin illustrates that binding of neomycin causes a conformational change which would affect further transcription processes. Thus, aminoglycosides represent lead compounds for the discovery of antiviral therapeutics against influenza A virus.
authors.affiliation: Department of Chemistry, KAIST, 291 Daehak-ro, Yuseong-gu, Daejeon 305-701, Korea.
authors.forename: Henna
authors.initials: H
authors.lastname: Kim
authors.forename: Mi-Kyung
authors.initials: MK
authors.lastname: Lee
authors.forename: Junsang
authors.initials: J
authors.lastname: Ko
authors.forename: Chin-Ju
authors.initials: CJ
authors.lastname: Park
authors.forename: Meehyein
authors.initials: M
authors.lastname: Kim
authors.forename: Yujeong
authors.initials: Y
authors.lastname: Jeong
authors.forename: Sungwoo
authors.initials: S
authors.lastname: Hong
authors.forename: Gabriele
authors.initials: G
authors.lastname: Varani
authors.forename: Byong-Seok
authors.initials: BS
authors.lastname: Choi
mesh_terms: D000617:Aminoglycosides / Q000737:chemistry* / Q000378:metabolism*; D000998:Antiviral Agents / Q000737:chemistry / Q000378:metabolism; D009980:Influenza A virus / Q000235:genetics*; D009355:Neomycin / Q000737:chemistry / Q000378:metabolism; D012367:RNA, Viral / Q000235:genetics*
chemical_list: D000617:Aminoglycosides; D000998:Antiviral Agents; D012367:RNA, Viral; D009355:Neomycin