title: Effect of age and correlation between esophageal visceral chemosensitivity and mechanosensitivity in healthy Japanese subjects.
abstract: BACKGROUND
  The aim of this study was to examine the impact of age on esophageal sensation, and to determine whether esophageal mechanosensitivity and chemosensitivity are correlated in healthy Japanese subjects.
  
  
  METHODS
  To evaluate chemosensitivity, a catheter was inserted and placed 10 cm above the upper border of the lower esophageal sphincter (LES), which was determined with an esophageal manometric catheter. After saline had been infused into the esophagus at a rate of 10 mL/min for 2 min, 0.1 N hydrochloric acid, instead of saline-without the subjects' knowledge-was infused for 10 min at the same rate. The acid perfusion sensitivity score (APSS) was assessed. To evaluate mechanosensitivity, a barostat test was performed, with a balloon being placed 10 cm above the upper border of the LES. The initial perception threshold (IPT), pain threshold (PT), and maximal pain were quantified.
  
  
  RESULTS
  The APSS was significantly inversely correlated with age. IPT, PT, and mean maximal pain were significantly correlated with age. Body mass index, drinking, and smoking habits were not correlated with the esophageal perception threshold. The correlation of chemosensitivity and mechanosensitivity was also assessed, and the APSS was inversely correlated with IPT, PT, and maximal pain.
  
  
  CONCLUSIONS
  The thresholds of esophageal visceral chemosensitivity and mechanosensitivity in same individuals were significantly correlated and both of these thresholds were inversely correlated with age.
authors.affiliation: Division of Upper Gastroenterology, Department of Internal Medicine, Hyogo College of Medicine, 1-1 Mukogawa-cho, Nishinomiya, Hyogo, 663-8501, Japan.
authors.forename: Takahisa
authors.initials: T
authors.lastname: Yamasaki
authors.forename: Tadayuki
authors.initials: T
authors.lastname: Oshima
authors.forename: Toshihiko
authors.initials: T
authors.lastname: Tomita
authors.forename: Takashi
authors.initials: T
authors.lastname: Kondo
authors.forename: Fumihiko
authors.initials: F
authors.lastname: Toyoshima
authors.forename: Jun
authors.initials: J
authors.lastname: Sakurai
authors.forename: Hirokazu
authors.initials: H
authors.lastname: Fukui
authors.forename: Takayuki
authors.initials: T
authors.lastname: Matsumoto
authors.forename: Jiro
authors.initials: J
authors.lastname: Watari
authors.forename: Hiroto
authors.initials: H
authors.lastname: Miwa
mesh_terms: D000328:Adult; D000368:Aged; D000375:Aging / Q000502:physiology*; D004106:Dilatation; D004947:Esophagus / Q000187:drug effects* / Q000502:physiology; D005260:Female; D006801:Humans; D006851:Hydrochloric Acid / Q000494:pharmacology; D008297:Male; D008365:Manometry; D040542:Mechanotransduction, Cellular / Q000502:physiology; D008875:Middle Aged; D010147:Pain Measurement / Q000379:methods; D017288:Pain Threshold / Q000502:physiology; D012684:Sensory Thresholds / Q000502:physiology; D013314:Stress, Mechanical; D055815:Young Adult
chemical_list: D006851:Hydrochloric Acid