title: Influenza A/H1N1 vaccination response is inadequate in down syndrome children when the latest cut-off values are used.
abstract: We determined the response of 48 Down syndrome children to 2 doses of influenza A/H1N1 vaccination. Ninety-two percent of the children reached the previously defined protective level (hemagglutination-inhibition titer ≥1:40), but only 27% of the children reached the level of ≥1:110 which was recently described to predict the conventional 50% clinical protection rate in children. Further studies, and potentially adaptations of the schedule, are needed.
authors.affiliation: Department of Pediatrics, Jeroen Bosch Hospital, `s-Hertogenbosch, Veldhoven, the Netherlands.
authors.forename: Maaike A
authors.initials: MA
authors.lastname: Kusters
authors.forename: Vinus L A
authors.initials: VL
authors.lastname: Bok
authors.forename: W E A
authors.initials: WE
authors.lastname: Bolz
authors.forename: E G W
authors.initials: EG
authors.lastname: Huijskens
authors.forename: M F
authors.initials: MF
authors.lastname: Peeters
authors.forename: Esther
authors.initials: E
authors.lastname: de Vries
mesh_terms: D000293:Adolescent; D000914:Antibodies, Viral / Q000097:blood*; D002648:Child; D002675:Child, Preschool; D004314:Down Syndrome / Q000276:immunology*; D005260:Female; D006385:Hemagglutination Inhibition Tests; D006801:Humans; D007223:Infant; D053118:Influenza A Virus, H1N1 Subtype / Q000276:immunology*; D007252:Influenza Vaccines / Q000008:administration & dosage* / Q000276:immunology*; D007251:Influenza, Human / Q000517:prevention & control*; D008297:Male
chemical_list: D000914:Antibodies, Viral; D007252:Influenza Vaccines