title: Cell polarisation and the immunological synapse.
abstract: Directed secretion by immune cells requires formation of the immunological synapse at the site of cell-cell contact, concomitant with a dramatic induction of cell polarity. Recent findings provide us with insights into the various steps that are required for these processes: for example, the first identification of a protein at the centrosome that regulates its relocation to the plasma membrane; the use of super-resolution imaging techniques to reveal a residual actin network at the immunological synapse that may permit secretory granule exocytosis; and the drawing of parallels between primary cilia and IS architecture. Here we discuss these and other novel findings that have advanced our understanding of the complex process of immunological synapse formation and subsequent induced cell polarity in immune cells.
authors.affiliation: Cambridge Institute for Medical Research, Addenbrooke's Hospital, Cambridge, CB2 0XY, England, UK.
authors.forename: Karen L
authors.initials: KL
authors.lastname: Angus
authors.forename: Gillian M
authors.initials: GM
authors.lastname: Griffiths
mesh_terms: D000199:Actins / Q000378:metabolism; D000818:Animals; D002462:Cell Membrane / Q000378:metabolism; D016764:Cell Polarity; D018385:Centrosome / Q000378:metabolism; D002923:Cilia / Q000276:immunology / Q000378:metabolism; D005089:Exocytosis / Q000276:immunology; D054992:Immunological Synapses / Q000378:metabolism*; D007694:Killer Cells, Natural / Q000166:cytology / Q000276:immunology / Q000378:metabolism; D022142:Secretory Vesicles / Q000378:metabolism; D013602:T-Lymphocytes, Cytotoxic / Q000166:cytology / Q000276:immunology / Q000378:metabolism
chemical_list: D000199:Actins