title: [Systemic distribution of prorenin and its receptor].
abstract: The (pro)renin receptor was first identified as a 350-amino acid protein with a single transmembrane domain. This receptor binds to prorenin to mediate its dual functions: activation of ERK1/2 independently from angiotensin II generation and induction of full enzymatic activity to initiate angiotensin II-dependent effects. (Pro) renin receptor has recently been shown to undergo intracellular processing, such that it exists in three different molecular forms. These include the full-length (pro)renin receptor, truncated amino-terminal soluble fragment, and carboxy-terminal fragment containing an accessory protein of the vacuolar-type H(+)-ATPase. Their exact distributions and existing molecular forms remain to be determined.
authors.affiliation: Molecular Endocrinology, Cedars-Sinai Medical Center, USA.
authors.forename: Yuji
authors.initials: Y
authors.lastname: Tani
authors.forename: Masayoshi
authors.initials: M
authors.lastname: Shichiri
mesh_terms: D000818:Animals; D006801:Humans; D011956:Receptors, Cell Surface / Q000032:analysis / Q000378:metabolism*; D012083:Renin / Q000378:metabolism*; D012084:Renin-Angiotensin System; D015398:Signal Transduction; D025262:Vacuolar Proton-Translocating ATPases / Q000032:analysis / Q000378:metabolism*; D000093342:Prorenin Receptor
chemical_list: D011956:Receptors, Cell Surface; D012083:Renin; D025262:Vacuolar Proton-Translocating ATPases; C458319:ATP6AP2 protein, human; D000093342:Prorenin Receptor