title: [Correction of early cognitive disorders in school-age children operated under total intravenous anaesthesia].
abstract: The aim of the study was to assess the possibility and effectiveness of hopaten acid use for early postoperative cognitive dysfunction correction in children of school age.
  
  
  METHODS
  In compliance with inclusion and exclusion criteria, totally 40 children of school age (7-16 years old, ASA status I-II) with surgical pathology: (varicocele, cryptorchidism, inguinal hernia) were included A comperative assessment of neuropsychic status during pre - and postoperative are period in children, operated under propofol-fentanyl total intravenous anesthesia (TIVA) was conducted All patients were randomized to the control (without cepebroprotection 1st group, 20 children) and experimental (using cepebroprotection with hopaten acid within 1 month after the operation, 2nd group, 20 children) groups. Dimension of the study: Harvard standard monitoring, respiratory gas composition, neuropsychic tests (Bourdon test, "10 words test", etc.).
  
  
  RESULTS
  For full compatibility groups (age, ASA status and anthropometric data, equal operation duration and the equipotential drug dosage adjustment is revealed, that in group of propofol-fentanyl TIVA in the early postoperative period in school age children postoperative cognitive dysfunction (POCD) is developing, which in case of absence of the corresponding correction is maintained after 1 month after operation (at least) in 80% of cases. In the application of hopaten acid cerebroprotection (40 mg/kg per day) severity of POCD reliably is reduced or compensated by the time of discharge from the hospital (3-7-th day when non-traumatic interventions), and 1 month after the operation in 30% of patients experienced improvement of cognitive functions, which proves the effectiveness of hopaten acid for POCD treatment.
  
  
  CONCLUSIONS
  In case of propofol-fentanyl TIVA anesthesia in children of school age is indicated preventive prescription of multimodal cerebroprotectors without age limitations (for example hopaten acid (40 mg/kg per day) for POCD treatment.
authors.forename: A M
authors.initials: AM
authors.lastname: Ovezov
authors.forename: M A
authors.initials: MA
authors.lastname: Lobov
authors.forename: M V
authors.initials: MV
authors.lastname: Panteleeva
authors.forename: A V
authors.initials: AV
authors.lastname: Lugovoĭ
authors.forename: P S
authors.initials: PS
authors.lastname: Miatchin
authors.forename: I E
authors.initials: IE
authors.lastname: Gus'kov
mesh_terms: D000293:Adolescent; D000771:Anesthesia, Intravenous / Q000009:adverse effects* / Q000379:methods; D019162:Anesthetics, Combined / Q000009:adverse effects*; D018686:Anesthetics, Intravenous / Q000009:adverse effects*; D002648:Child; D003072:Cognition Disorders / Q000209:etiology / Q000517:prevention & control* / Q000523:psychology; D005260:Female; D005283:Fentanyl / Q000009:adverse effects; D006801:Humans; D008297:Male; D057567:Memory, Long-Term / Q000187:drug effects; D008570:Memory, Short-Term / Q000187:drug effects; D009483:Neuropsychological Tests; D018697:Nootropic Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D010205:Pantothenic Acid / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000627:therapeutic use; D059035:Perioperative Period; D015742:Propofol / Q000009:adverse effects; D016896:Treatment Outcome; D005680:gamma-Aminobutyric Acid / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000627:therapeutic use
chemical_list: D019162:Anesthetics, Combined; D018686:Anesthetics, Intravenous; D018697:Nootropic Agents; C016030:pantogab; D010205:Pantothenic Acid; D005680:gamma-Aminobutyric Acid; D005283:Fentanyl; D015742:Propofol