title: Adsorptive-mediated brain delivery systems.
abstract: The blood-brain barrier (BBB), which impedes drug penetration into the central nervous system, is composed of specific structures formed by brain capillary endothelial cells and sheathed by astrocytic end-feet through basement membrane. Many brain drug delivery strategies have focused on adsorptive-mediated transcytosis (AMT), which is triggered by electrostatic interaction between cationic molecules and anionic microdomains on the cytoplasm membrane of the brain capillary endothelial cells. AMT-based drug delivery to the brain can be achieved by using cationic proteins and basic oligopeptides such as cell-penetrating peptides as targetors. Large therapeutic molecules such as neuropeptides and proteins or even drug-encapsulated vectors such as liposomes and nanoparticles can be allowed to access brain parenchyma through AMT when conjugated with these cationic targetors. In this review, I briefly discuss adsorptive-mediated brain delivery systems that may provide physiologic-based strategies for enhanced delivery of therapeutic substances through the BBB.
authors.affiliation: Department of Biomedical and Pharmaceutical Sciences, College of Pharmacy, The University of Rhode Island, 41 Lower College Road, Kingston, RI 02881, USA. weilu@uri.edu
authors.forename: Wei
authors.initials: W
authors.lastname: Lu
mesh_terms: D000327:Adsorption; D000818:Animals; D001812:Blood-Brain Barrier; D001932:Brain Neoplasms / Q000628:therapy; D057846:Cell-Penetrating Peptides / Q000008:administration & dosage; D016503:Drug Delivery Systems; D015316:Genetic Therapy; D005910:Glioma / Q000628:therapy; D006801:Humans; D008081:Liposomes; D053758:Nanoparticles / Q000737:chemistry; D004364:Pharmaceutical Preparations / Q000008:administration & dosage / Q000737:chemistry; D011506:Proteins / Q000008:administration & dosage / Q000737:chemistry; D053221:TNF-Related Apoptosis-Inducing Ligand / Q000235:genetics; D057900:Transcytosis
chemical_list: D057846:Cell-Penetrating Peptides; D008081:Liposomes; D004364:Pharmaceutical Preparations; D011506:Proteins; D053221:TNF-Related Apoptosis-Inducing Ligand