title: Trifluoromethylation of α-haloketones.
abstract: The C-X bond (X = Br, Cl) of α-haloketones is smoothly trifluoromethylated with the fluoroform-derived CuCF(3) reagent recently developed in our laboratories. This is the first nucleophilic α-trifluoromethylation reaction of carbonyl compounds and a rare example of CF(3)-C(sp(3)) coupling. The transformation employs only low-cost chemicals and cleanly occurs in up to 99% yield at room temperature, thereby providing an unprecedentedly easy entry to valuable 2,2,2-trifluoroethylketones.
authors.affiliation: Institute of Chemical Research of Catalonia, Tarragona 43007, Spain.
authors.forename: Petr
authors.initials: P
authors.lastname: Novák
authors.forename: Anton
authors.initials: A
authors.lastname: Lishchynskyi
authors.forename: Vladimir V
authors.initials: VV
authors.lastname: Grushin
mesh_terms: D005617:Chlorofluorocarbons, Methane / Q000737:chemistry*; D006219:Halogens / Q000737:chemistry*; D007659:Ketones / Q000737:chemistry*; D013237:Stereoisomerism; D013379:Substrate Specificity; D013696:Temperature
chemical_list: D005617:Chlorofluorocarbons, Methane; D006219:Halogens; D007659:Ketones; C009554:fluoroform