title: [Application value of low-dose computed tomography for the screening of lung cancer in high-risk group].
abstract: OBJECTIVE
  To analyze the value of low-dose computed tomography (LDCT) in early screening of lung cancer in high-risk group.
  
  
  METHODS
  LDCT was performed in 1551 adults over 40-years old (male 1054, female 497) for the screening of lung cancer in Examination Center of West China Hospital, Sichuan University, and the subjects were divided into high-risk group and non-high-risk group according to risk factors of lung caner. The detection rates of lung lesion and lung cancer in these two groups were carefully analyzed.
  
  
  RESULTS
  In the people over 40-years old,the detection rate of pulmonary lesions by LDCT was 54.41% (844/1551), the detection rate of nodules was 29.4% (456/1551). Detection rate of lung cancer was 0.51% (8/1551), while it was 1.21% (7/577) in high-risk group, and 2.01% (6/298) in heavy smoker group. The difference of lung cancer detection rate was significant (P < 0.05). When stratified with the number of risk factors, the detection rate of lung cancer by LDCT was 0.10% (1/974) in the subjects without any high-risk factors, 0.98% (5/506) in the subjects with one high-risk factor and 2.86% (2/70) in the subjects with more high-risk factors, and the differences were stastatically significant (P < 0.05).
  
  
  CONCLUSIONS
  LDCT can detect asymptomatic lung cancer sensitively with low radiation dose, which could be helpful for the screening of lung cancer.
authors.affiliation: General Ward, West China Hospital, Sichuan University, Chengdu 610041, China.
authors.forename: Yi
authors.initials: Y
authors.lastname: Lei
authors.forename: Bo-Jiang
authors.initials: BJ
authors.lastname: Chen
authors.forename: Li
authors.initials: L
authors.lastname: Zeng
authors.forename: Wei-Min
authors.initials: WM
authors.lastname: Li
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002681:China; D055088:Early Detection of Cancer / Q000379:methods*; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000000981:diagnostic imaging*; D008297:Male; D008403:Mass Screening / Q000379:methods; D008875:Middle Aged; D011829:Radiation Dosage; D013902:Radiography, Thoracic; D012307:Risk Factors; D012907:Smoking / Q000009:adverse effects; D014057:Tomography, X-Ray Computed / Q000379:methods*