title: Can the beneficial effects of methionine restriction in rats be explained in part by decreased methylglyoxal generation resulting from suppressed carbohydrate metabolism?
abstract: The mechanisms by which dietary restriction of the amino acid methionine exerts beneficial effects on oxidative damage towards rat liver mitochondria are discussed. It is suggested that methionine restriction decreases amino acid utilization in protein synthesis which, by decreasing synthesis of non-essential amino acids from carbohydrate precursors, also decreases formation of the highly deleterious glycolytic by-product methylglyoxal, a well-recognised source of age-related damage including formation of reactive oxygen species, mitochondrial dysfunction and proteotoxicity. Additionally, decreased protein synthesis will lower the error-protein load which the protein quality system (proteasomal and autophagic) must deal with to maintain proteostasis.
authors.affiliation: Aston Research Centre for Healthy Ageing (ARCHA), School of Health and Life Sciences, Aston University, Birmingham B4 7ET, UK. alanandjill@lineone.net
authors.forename: Alan R
authors.initials: AR
authors.lastname: Hipkiss
mesh_terms: D000375:Aging / Q000378:metabolism*; D000818:Animals; D050260:Carbohydrate Metabolism; D004099:Dihydroxyacetone Phosphate / Q000378:metabolism; D019648:Foods, Specialized; D005986:Glyceraldehyde 3-Phosphate / Q000378:metabolism; D006019:Glycolysis; D008136:Longevity / Q000502:physiology*; D008715:Methionine / Q000378:metabolism*; D008930:Mitochondria, Liver / Q000378:metabolism*; D018384:Oxidative Stress; D014176:Protein Biosynthesis; D011765:Pyruvaldehyde / Q000378:metabolism; D051381:Rats; D017382:Reactive Oxygen Species / Q000378:metabolism
chemical_list: D017382:Reactive Oxygen Species; D005986:Glyceraldehyde 3-Phosphate; D004099:Dihydroxyacetone Phosphate; D011765:Pyruvaldehyde; D008715:Methionine