title: Detection of respiratory viruses in asymptomatic children undergoing allogeneic hematopoietic cell transplantation.
abstract: Detection of respiratory viruses by molecular methods, in children without respiratory symptoms undergoing hematopoietic cell transplantation (HCT), has not been well described. A prospective study of 33 asymptomatic children detected respiratory viruses in 8 of 33 (24%) patients before HCT. Human rhinovirus (HRV) was detected in five patients, and human adenovirus (hADV) in three patients. Two additional patients shed HRV, and one shed human coronavirus (hCoV), post-HCT. Two patients had co-infections. Of the 11 asymptomatic patients where respiratory virus was detected, 3 (27%) later developed an upper respiratory tract infection, from the same virus.
authors.affiliation: Department of Bone Marrow Transplantation and Cellular Therapy (BMTCT), St. Jude Children's Research Hospital, Memphis, TN 38105, USA. ashok.srinivasan@stjude.org
authors.forename: Ashok
authors.initials: A
authors.lastname: Srinivasan
authors.forename: Patricia
authors.initials: P
authors.lastname: Flynn
authors.forename: Zhengming
authors.initials: Z
authors.lastname: Gu
authors.forename: Christine
authors.initials: C
authors.lastname: Hartford
authors.forename: Richard
authors.initials: R
authors.lastname: Lovins
authors.forename: Anusha
authors.initials: A
authors.lastname: Sunkara
authors.forename: Deo K
authors.initials: DK
authors.lastname: Srivastava
authors.forename: Wing
authors.initials: W
authors.lastname: Leung
authors.forename: Randall T
authors.initials: RT
authors.lastname: Hayden
mesh_terms: D000260:Adenoviruses, Human / Q000302:isolation & purification*; D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D015331:Cohort Studies; D017934:Coronavirus / Q000302:isolation & purification*; D005260:Female; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D007223:Infant; D008297:Male; D011446:Prospective Studies; D012229:Rhinovirus / Q000302:isolation & purification*; D014184:Transplantation, Homologous