title: Short communication: Glutamine increases autophagy of liver cells in weaned calves.
abstract: The objectives of this study were to determine the effects of an increased jugular supply of l-Gln on the autophagy of weaned calves. At 35 d of age, 24 Holstein calves (initial body weight of 50±0.5 kg; 35±2 d of age) were randomly allocated to 4 treatments, with each treatment including 5 male calves and 1 female calf. Holstein calves were assigned to treatments of (1) intravenous infusion of 2d of 0.85% NaCl (control group) (2) intravenous infusion of 8 g/d of L-Gln mixed with 2d of 0.85% NaCl solution, (3) intravenous infusion of 16 g/d of L-Gln mixed with 2d of 0.85% NaCl solution, and (4) intravenous infusion of 32 g/d of L-Gln mixed with 2d of 0.85% NaCl. The infusion was administered 2h/d for 7 consecutive days starting on d 1 after weaning. Feed and water were freely available to all calves. All calves were killed on d 7 postweaning to measure the autophagy of liver cells. The level of autophagy in liver cells was improved when the Gln infusion dose increased.
authors.affiliation: State Key Laboratory of Animal Nutrition, College of Animal Science and Technology, China Agricultural University, Beijing, China.
authors.forename: Z Y
authors.initials: ZY
authors.lastname: Hu
authors.forename: S L
authors.initials: SL
authors.lastname: Li
authors.forename: Z J
authors.initials: ZJ
authors.lastname: Cao
mesh_terms: D000818:Animals; D000831:Animals, Newborn / Q000378:metabolism / Q000502:physiology; D001343:Autophagy / Q000187:drug effects*; D002417:Cattle; D004305:Dose-Response Relationship, Drug; D005260:Female; D005973:Glutamine / Q000008:administration & dosage / Q000494:pharmacology*; D007262:Infusions, Intravenous / Q000662:veterinary; D008099:Liver / Q000187:drug effects* / Q000502:physiology; D008297:Male; D014886:Weaning
chemical_list: D005973:Glutamine