title: Equine multinodular pulmonary fibrosis in association with asinine herpesvirus type 5 and equine herpesvirus type 5: a case report.
abstract: A standardbred gelding with a history of 10 days pyrexia and lethargy was referred to the Equine Hospital at the Swedish University of Agricultural Sciences in Uppsala, Sweden.The horse had tachypnea with increased respiratory effort and was in thin body condition. Laboratory findings included leukocytosis, hyperfibrinogenemia and hypoxemia. Thoracic radiographs showed signs of pneumonia with a multifocal nodular pattern, which in combination with lung biopsy findings indicated Equine Multinodular Pulmonary Fibrosis (EMPF). EMPF is a recently described disease in adult horses with clinical signs of fever, weight loss and respiratory problems. The pathological findings include loss of functional pulmonary parenchyma due to extensive nodular interstitial fibrosis which has been related to infection with the equine herpesvirus type 5 (EHV-5). In this case, lung biopsy and tracheal wash samples tested positive for both asinine herpesvirus type 5 (AHV-5) and EHV-5 using PCR assays. The horse failed to respond to treatment and was euthanized for humane reasons. Postmortem examination confirmed the diagnosis of EMPF. This case suggests that not only EHV-5 alone should be considered in association with the development of this disease.
authors.affiliation: Department of Virology, Immunology and Parasitology, The National Veterinary Institute, Uppsala, Sweden. helena.back@sva.se
authors.forename: Helena
authors.initials: H
authors.lastname: Back
authors.forename: Anna
authors.initials: A
authors.lastname: Kendall
authors.forename: Rodrigo
authors.initials: R
authors.lastname: Grandón
authors.forename: Karin
authors.initials: K
authors.lastname: Ullman
authors.forename: Louise
authors.initials: L
authors.lastname: Treiberg-Berndtsson
authors.forename: Karl
authors.initials: K
authors.lastname: Ståhl
authors.forename: John
authors.initials: J
authors.lastname: Pringle
mesh_terms: D000818:Animals; D004259:DNA-Directed DNA Polymerase / Q000235:genetics / Q000378:metabolism; D017809:Fatal Outcome; D018142:Gammaherpesvirinae / Q000145:classification* / Q000235:genetics / Q000302:isolation & purification* / Q000378:metabolism; D006566:Herpesviridae Infections / Q000175:diagnosis / Q000473:pathology / Q000662:veterinary* / Q000821:virology; D006734:Horse Diseases / Q000175:diagnosis* / Q000473:pathology / Q000821:virology; D006736:Horses; D008297:Male; D016133:Polymerase Chain Reaction / Q000662:veterinary; D011658:Pulmonary Fibrosis / Q000175:diagnosis / Q000473:pathology / Q000662:veterinary* / Q000821:virology; D013045:Species Specificity; D013548:Sweden
chemical_list: D004259:DNA-Directed DNA Polymerase