title: A new treatment alternative for sensitive teeth: a desensitizing oral rinse.
abstract: OBJECTIVE
  Tooth sensitivity is a common, painful dental condition. Consumer dental products, mostly dentifrices, play an important role in sensitivity treatment. The objective of this review is to describe a new mouthwash-based desensitizing technology.
  
  
  METHODS
  Background literature concerning desensitizing products is reviewed. Potassium salts are the most commonly used active ingredients in desensitizing dentifrices. Clinical studies show that while potassium salt dentifrices are generally effective; most formulations require several weeks to exert their desensitizing effect. Recently, a new desensitizing dentifrice containing the amino acid arginine was introduced. This dentifrice acts to occlude the dentinal tubules, and has been shown to be highly effective in multiple clinical studies. This arginine-containing dentifrice has also been shown to provide instant relief of sensitivity pain when applied directly to the sensitive tooth surface. In contrast to dentifrices, there are few desensitizing mouthwashes available. Building on the success of the arginine-based dentifrice, an arginine-based mouthwash formula was developed and tested.
  
  
  METHODS
  Published studies in peer-reviewed publications.
  
  
  METHODS
  Controlled and blinded clinical studies to provide evidence of efficacy. In vitro studies are included to indicate the mechanism of action. This review includes studies testing the new arginine-based desensitizing mouthwash.
  
  
  CONCLUSIONS
  Clinical findings indicate that this new desensitizing mouthwash, based on the Pro-Argin™ mouthwash technology effectively reduces sensitivity symptoms and can be used alone or as a adjunct to the use of the arginine-containing dentifrice in the home treatment of tooth sensitivity.
authors.affiliation: Department of Oral Biology, New Jersey Dental School, University of Medicine and Dentistry of New Jersey, 185 South Orange Ave, Newark, NJ 07103, USA. markowkj@umdnj.edu
authors.forename: Kenneth
authors.initials: K
authors.lastname: Markowitz
mesh_terms: D001120:Arginine / Q000737:chemistry / Q000627:therapeutic use*; D002119:Calcium Carbonate / Q000737:chemistry / Q000627:therapeutic use*; D057133:Dentin Desensitizing Agents / Q000737:chemistry / Q000627:therapeutic use*; D003807:Dentin Sensitivity / Q000188:drug therapy*; D019234:Dentinal Fluid; D011756:Diphosphates / Q000627:therapeutic use; D004338:Drug Combinations; D005459:Fluorides / Q000737:chemistry / Q000627:therapeutic use*; D006801:Humans; D008298:Maleates / Q000627:therapeutic use*; D009067:Mouthwashes / Q000737:chemistry / Q000627:therapeutic use*; D010710:Phosphates / Q000737:chemistry / Q000627:therapeutic use*; D011095:Polyethylenes / Q000627:therapeutic use*; D012969:Sodium Fluoride / Q000627:therapeutic use
chemical_list: D057133:Dentin Desensitizing Agents; D011756:Diphosphates; D004338:Drug Combinations; D008298:Maleates; D009067:Mouthwashes; D010710:Phosphates; D011095:Polyethylenes; C585805:pro-argin; C012980:fluorophosphate; C107241:diphosphoric acid; D012969:Sodium Fluoride; C043105:poly(methyl vinyl ether-co-maleic anhydride); D001120:Arginine; D002119:Calcium Carbonate; D005459:Fluorides