title: Formation of a physical stable delivery system by simply autoclaving nanostructured lipid carriers (NLC).
abstract: A unique long term stable carrier system for poorly soluble drugs was obtained by simply autoclaving nanostructured lipid carriers (NLC). NLC composed of Precirol ATO, oleic acid, glycerol 85%, Eumulgin SML 20 and water as well as NLC loaded with the poorly soluble drug Itraconazole formed a special organized matrix containing lamellar bilayers similar to biological membranes after the sterilization process. The tendency to expel the poorly soluble drug from the matrix was thereby avoided.
authors.affiliation: Institute of Pharmaceutical Sciences, Department of Pharmaceutical Technology, Karl-Franzens Universität Graz, Humboldtstrasse 46, 8010 Graz, Austria. jana-pardeike@web.de
authors.forename: Jana
authors.initials: J
authors.lastname: Pardeike
authors.forename: Sabrina
authors.initials: S
authors.lastname: Weber
authors.forename: Nadejda
authors.initials: N
authors.lastname: Matsko
authors.forename: Andreas
authors.initials: A
authors.lastname: Zimmer
mesh_terms: D004337:Drug Carriers / Q000737:chemistry*; D006358:Hot Temperature; D017964:Itraconazole / Q000737:chemistry; D008055:Lipids / Q000737:chemistry*; D049329:Nanostructures / Q000737:chemistry*
chemical_list: D004337:Drug Carriers; D008055:Lipids; D017964:Itraconazole