title: Quantification of anaesthetic effects on atrial fibrillation rate by partial least-squares.
abstract: The mechanism underlying atrial fibrillation (AF) remains poorly understood. Multiple wandering propagation wavelets drifting through both atria under hierarchical models are not understood. Some pharmacological drugs, known as antiarrhythmics, modify the cardiac ionic currents supporting the fibrillation process within the atria and may modify the AF propagation dynamics terminating the fibrillation process. Other medications, theoretically non-antiarrhythmic, may slightly affect the fibrillation process in non-defined mechanisms. We evaluated whether the most commonly used anaesthetic agent, propofol, affects AF patterns. Partial least-squares (PLS) analysis was performed to reduce significant noise into the main latent variables to find the differences between groups. The final results showed an excellent discrimination between groups with slow atrial activity during the propofol infusion.
authors.affiliation: Escuela Universitaria Politécnica, Campus Universitario, Group of Bioengineering Innovation (GIBI), DIEEAC, UCLM,. Camino del Pozuelo sn, E-16071, Cuenca, Spain. raquel.cervigon@uclm.es
authors.forename: R
authors.initials: R
authors.lastname: Cervigón
authors.forename: J
authors.initials: J
authors.lastname: Moreno
authors.forename: R B
authors.initials: RB
authors.lastname: Reilly
authors.forename: J
authors.initials: J
authors.lastname: Pérez-Villacastín
authors.forename: F
authors.initials: F
authors.lastname: Castells
mesh_terms: D000777:Anesthetics / Q000494:pharmacology*; D001281:Atrial Fibrillation / Q000503:physiopathology* / Q000628:therapy; D017115:Catheter Ablation; D055724:Electrophysiological Phenomena / Q000187:drug effects*; D005260:Female; D006325:Heart Atria / Q000187:drug effects / Q000503:physiopathology; D006801:Humans; D016018:Least-Squares Analysis; D008297:Male; D008875:Middle Aged; D015742:Propofol / Q000494:pharmacology*; D012815:Signal Processing, Computer-Assisted; D013997:Time Factors
chemical_list: D000777:Anesthetics; D015742:Propofol