title: LAPTM4B allele *2 is a marker of poor prognosis for gallbladder carcinoma.
abstract: BACKGROUND
  Lysosomal protein transmembrane 4 beta (LAPTM4B) is a novel cancer-related gene which has two alleles designated LAPTM4B*1 and LAPTM4B*2. In this study we investigated the correlation of LAPTM4B genotype with prognosis and clinicopathologic features in patients who had undergone curative resection for gallbladder carcinoma (GBC).
  
  
  RESULTS
  PCR assay was performed to determine the LAPTM4B genotype in 85 patients. The correlation of LAPTM4B genotype with clinicopathologic parameters was assessed with the Chi-squared test. Differences in patient survival were determined by the Kaplan-Meier method. Multivariate analysis of prognostic factors was carried out with Cox regression analysis. Patients with LAPTM4B *2 had both significantly shorter overall survival (OS) and shorter disease-free survival (DFS) (both P<0.001). Multivariate analysis showed that LAPTM4B genotype is a prognostic factor for OS and DFS (both P<0.001).
  
  
  CONCLUSIONS
  LAPTM4B allele *2 is a risk factor associated with poor prognosis in patients with resected GBC, and LAPTM4B status may be therefore be useful preoperatively as an adjunct in evaluation of the operability of GBC.
authors.affiliation: Department of Interventional Radiology and Vascular Surgery, Peking University Third Hospital, Beijing, China.
authors.forename: Guojun
authors.initials: G
authors.lastname: Zhai
authors.forename: Kaowen
authors.initials: K
authors.lastname: Yan
authors.forename: Xiaoxu
authors.initials: X
authors.lastname: Ji
authors.forename: Wenrui
authors.initials: W
authors.lastname: Xu
authors.forename: Jiuling
authors.initials: J
authors.lastname: Yang
authors.forename: Fuxia
authors.initials: F
authors.lastname: Xiong
authors.forename: Jing
authors.initials: J
authors.lastname: Su
authors.forename: Michael A
authors.initials: MA
authors.lastname: McNutt
authors.forename: Hua
authors.initials: H
authors.lastname: Yang
mesh_terms: D000328:Adult; D000368:Aged; D000483:Alleles; D014408:Biomarkers, Tumor / Q000235:genetics*; D016009:Chi-Square Distribution; D005260:Female; D005706:Gallbladder Neoplasms / Q000235:genetics* / Q000473:pathology / Q000601:surgery; D005838:Genotype; D006801:Humans; D053208:Kaplan-Meier Estimate; D008297:Male; D008565:Membrane Proteins / Q000235:genetics*; D008875:Middle Aged; D015999:Multivariate Analysis; D015513:Oncogene Proteins / Q000235:genetics*; D016133:Polymerase Chain Reaction; D011379:Prognosis; D016016:Proportional Hazards Models; D018570:Risk Assessment / Q000706:statistics & numerical data; D012307:Risk Factors
chemical_list: D014408:Biomarkers, Tumor; C477083:LAPTM4B protein, human; D008565:Membrane Proteins; D015513:Oncogene Proteins