title: Pten-less dentate granule cells make fits.
abstract: Hippocampal dentate granule cell abnormalities are thought to play a causative role in temporal lobe epilepsy, but their precise contribution has not been dissociated from coexisting pathological changes. In this issue of Neuron, Pun et al. (2012) show, for the first time, that inducing proexcitatory changes in a subset of DGCs in isolation is sufficient to cause epilepsy in a rodent.
authors.affiliation: Department of Neurology and Neuroscience Graduate Program, University of Michigan Medical Center, Ann Arbor, MI 48109, USA.
authors.forename: Alison L
authors.initials: AL
authors.lastname: Althaus
authors.forename: Jack M
authors.initials: JM
authors.lastname: Parent
mesh_terms: D000818:Animals; D018891:Dentate Gyrus / Q000473:pathology*; D004827:Epilepsy / Q000235:genetics* / Q000473:pathology*; D005786:Gene Expression Regulation / Q000502:physiology*; D009474:Neurons / Q000473:pathology*; D058570:TOR Serine-Threonine Kinases / Q000378:metabolism*
chemical_list: C546843:mTOR protein, mouse; D058570:TOR Serine-Threonine Kinases