title: [Recomendations on the management of controversies in advanced castrate-resistant prostate cancer].
abstract: BACKGROUND
  Controversies and uncertainties among integral management of advanced castration resistant prostate cancer continue to exist despite the number of evidence based clinical practice guidelines published with high international consensus.
  
  
  OBJECTIVE
  To develop a document that reviews the management of controversies in advanced castration resistant prostate cancer, with recommendations from the definition, to the management in hormonal maneuvers, first-line treatment and second-line with new treatments as cabazitaxel or abirarerone and the multidisciplinary approach of the pathology with the goal of finding the most efficient, best time to act and safety.
  
  
  METHODS
  Two meetings of a multidisciplinary group of experts involved in the management of this disease (Oncologist and Urologist) where pooled analysis of original literature and reached consensus document of recommendations on castration resistant prostate cancer, reviewing and attempting to address the current controversies of the disease.
  
  
  RESULTS
  This document is endorsed by the corresponding Scientific Associations and Working Groups involved in the current management of Genitourinary Tumours: the Spanish Association of Urology (AEU) with the Uro-Oncoloy Group (GUO) and the Spanish Oncology of Genitourinary Group (SOGUG).
  
  
  CONCLUSIONS
  With the adaptation and implementation of this Document of Recommendations for clinical practice are available for the first time, a real road map for quality, efficiency and safety in the management of patients with CRPC.
authors.affiliation: Servicio de Urología, Hospital Universitario Virgen de las Nieves, Granada, España. cozarjm@yahoo.es
authors.forename: J M
authors.initials: JM
authors.lastname: Cózar
authors.forename: E
authors.initials: E
authors.lastname: Solsona
authors.forename: J
authors.initials: J
authors.lastname: Morote
authors.forename: B
authors.initials: B
authors.lastname: Miñana
authors.forename: J P
authors.initials: JP
authors.lastname: Maroto
authors.forename: A
authors.initials: A
authors.lastname: González Del Alba
authors.forename: M A
authors.initials: MA
authors.lastname: Climent
authors.forename: J
authors.initials: J
authors.lastname: Carles
authors.forename: A
authors.initials: A
authors.lastname: Alcaraz
authors.forename: D
authors.initials: D
authors.lastname: Castellano
mesh_terms: D006801:Humans; D008297:Male; D009367:Neoplasm Staging; D064129:Prostatic Neoplasms, Castration-Resistant / Q000188:drug therapy* / Q000473:pathology