title: [Study on intestinal absorption of mollugin and purpurin in rats].
abstract: OBJECTIVE
  To study the absorption kinetic characteristics of mollugin and purpurin in each intestinal segment of rats.
  
  
  METHODS
  The in situ single-way perfusion rat model was established to study absorption characteristics of mollugin and purpurin in each intestinal segment of rats. The volume of recirculation fluid was regulated by phenol red.
  
  
  RESULTS
  Different quality concentrations (12.33, 24.66, 49.32 mg x L(-1)) of mollugin and (8.455, 16.91, 33.82 mg x L(-1)) purpurin showed a concentration gradient of absorption dose in each intestinal segment, with the osmotic coefficient increasing to more than 0.2 x 10(-4) cm x s(-1). In the same concentration, mollugin and purpurin showed an identical trend of P(eff) in each intestinal segment in the order of colon > duodenum > ileum > jejunum, with a significant difference (P < 0.05).
  
  
  CONCLUSIONS
  Mollugin and purpurin are highly permeable in rat intestinal segments, with absorption in each segment, while the specific absorption existed in the colon segment.
authors.affiliation: Nanjing University of Chinese Medicine, Nanjing 210046, China. wangkan86@hotmail.com
authors.forename: Kan
authors.initials: K
authors.lastname: Wang
authors.forename: Xing
authors.initials: X
authors.lastname: Chen
authors.forename: Mingqiu
authors.initials: M
authors.lastname: Shan
authors.forename: Anwei
authors.initials: A
authors.lastname: Ding
mesh_terms: D000818:Animals; D000880:Anthraquinones / Q000378:metabolism*; D005260:Female; D007408:Intestinal Absorption; D008297:Male; D011714:Pyrans / Q000378:metabolism*; D051381:Rats; D017207:Rats, Sprague-Dawley; D015203:Reproducibility of Results
chemical_list: D000880:Anthraquinones; D011714:Pyrans; C046245:rubimaillin; C511975:purpurin anthraquinone