title: Hemodynamic analysis for transjugular intrahepatic portosystemic shunt (TIPS) in the liver based on a CT-image.
abstract: In this paper, we apply a 3-D flow model and a 1-D circulation model to the hemodynamic analysis of transjugular intrahepatic portosystemic shunt (TIPS), the therapy for treating acute portal hypertension (PH) induced diseases. Using the 3-D model we are able to simulate the blood flow within a patient-specific TIPS system which was reconstructed from a computed tomography image, and quantify such hemodynamic data as the wall shear stress and flow velocity. The 1-D model is used for the investigation of generic TIPS-induced hepatic circulation phenomena. By incorporating physiological data into the 1-D model we can reproduce some complex flow patterns such as the increased arterial flow after TIPS implantation, the formation of retrograde flow in the portal vein, etc. In particular, our model gives a quantitative analysis of the interplay between TIPS and hepatic flows. In conclusion, the presented computational model can be used for the theoretical analysis of TIPS, in which clinical decisions are often made based on contradictory considerations to balance the procedure-induced complications and the urgency of relieving acute PH symptoms.
authors.affiliation: Auckland Bioengineering Institute, The University of Auckland, Auckland, New Zealand. harvey.ho@auckland.ac.nz
authors.forename: Harvey
authors.initials: H
authors.lastname: Ho
authors.forename: Keagan
authors.initials: K
authors.lastname: Sorrell
authors.forename: Liqing
authors.initials: L
authors.lastname: Peng
authors.forename: Zhigang
authors.initials: Z
authors.lastname: Yang
authors.forename: Andrew
authors.initials: A
authors.lastname: Holden
authors.forename: Peter
authors.initials: P
authors.lastname: Hunter
mesh_terms: D000368:Aged; D003198:Computer Simulation; D006439:Hemodynamics; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods*; D008099:Liver / Q000033:anatomy & histology / Q000098:blood supply*; D008102:Liver Circulation / Q000502:physiology*; D008297:Male; D008955:Models, Cardiovascular; D011169:Portal Vein / Q000033:anatomy & histology / Q000502:physiology; D019168:Portasystemic Shunt, Transjugular Intrahepatic / Q000379:methods*; D014057:Tomography, X-Ray Computed / Q000379:methods*