title: The Kety-Schmidt technique for quantitative perfusion and oxygen metabolism measurements in the MR imaging environment.
abstract: The Kety-Schmidt technique provides quantitative measurement of whole-brain CBF. CBF is measured as the area between the arterial and venous washout curves of a diffusible tracer. Oxygen extraction and metabolism may be calculated from arterial and venous samples. In this report, we present a method for performing these measurements in an MR imaging environment. This technique could be useful for validation of MR imaging methods of hemodynamic and metabolic measurements in humans.
authors.affiliation: Mallinckrodt Institute of Radiology.
authors.forename: J J
authors.initials: JJ
authors.lastname: Lee
authors.forename: W J
authors.initials: WJ
authors.lastname: Powers
authors.forename: C B
authors.initials: CB
authors.lastname: Faulkner
authors.forename: P J
authors.initials: PJ
authors.lastname: Boyle
authors.forename: C P
authors.initials: CP
authors.lastname: Derdeyn
mesh_terms: D000465:Algorithms; D000818:Animals; D001921:Brain / Q000033:anatomy & histology / Q000378:metabolism*; D003198:Computer Simulation; D005260:Female; D006801:Humans; D007090:Image Interpretation, Computer-Assisted / Q000379:methods; D008252:Macaca fascicularis; D018810:Magnetic Resonance Angiography / Q000379:methods*; D008297:Male; D008954:Models, Biological; D009609:Nitrous Oxide / Q000493:pharmacokinetics*; D010092:Oximetry / Q000379:methods*; D010100:Oxygen / Q000378:metabolism*; D010101:Oxygen Consumption / Q000502:physiology; D048530:Papio anubis; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity
chemical_list: D009609:Nitrous Oxide; D010100:Oxygen