title: Reperfusion brain injury: focus on cellular bioenergetics.
abstract: Energy production for the maintenance of brain function fails rapidly with the onset of ischemia and is reinstituted with timely reperfusion. The key bioenergetic organelle, the mitochondrion, is strongly affected by a cascade of events occurring with ischemia and reperfusion. Enhanced production of reactive oxygen species, disruption of calcium homeostasis, and an inflammatory response are induced by reperfusion and have a profound effect on cellular bioenergetics in reversible stroke. The impact of perturbed bioenergetics on cellular homeostasis/function during and after ischemia are discussed. Because mitochondrial function can be compromised by derangements at more than one of the susceptible sites on this organelle, we propose that a combination therapy is needed for the restoration and maintenance of cellular bioenergetics after reperfusion.
authors.affiliation: Case Western Reserve University, Cleveland, OH, USA. sxp19@cwru.edu
authors.forename: Svetlana
authors.initials: S
authors.lastname: Pundik
authors.forename: Kui
authors.initials: K
authors.lastname: Xu
authors.forename: Sophia
authors.initials: S
authors.lastname: Sundararajan
mesh_terms: D000818:Animals; D001921:Brain / Q000473:pathology* / Q000502:physiology*; D001930:Brain Injuries / Q000378:metabolism* / Q000473:pathology / Q000503:physiopathology; D002560:Cerebrovascular Circulation / Q000502:physiology; D004734:Energy Metabolism / Q000502:physiology*; D006801:Humans; D017382:Reactive Oxygen Species / Q000378:metabolism; D015427:Reperfusion Injury / Q000378:metabolism* / Q000473:pathology / Q000503:physiopathology
chemical_list: D017382:Reactive Oxygen Species