title: HPV pathway profiling: HPV related cervical dysplasia and carcinoma studies.
abstract: Cervical cancer is the second most common malignancy among women worldwide. While more than 90% of cervical cancers carry one or more high risk HPV types, the exact relationship between HPV oncoproteins and signaling pathways alterations in cervical cancer remains to be clarified. Vaccines and targeted therapies are today considered of great potential for the improvement of patients' outcome. This review will focus on the interaction of HPV with cervical cancer pathway activations. Next generation high throughput screening technologies for molecular and protein profiling as well as innovative logistics, necessary for the implementation of the personalized care of cervical cancer patients will be discussed.
authors.affiliation: Département d'Oncologie, Institut Curie, Paris, France. suzy.scholl@curie.net
authors.forename: Susy M
authors.initials: SM
authors.lastname: Scholl
authors.forename: Maud
authors.initials: M
authors.lastname: Kamal
authors.forename: Léanne
authors.initials: L
authors.lastname: De Koning
authors.forename: Attila
authors.initials: A
authors.lastname: Kereszt
authors.forename: Ekaterina S
authors.initials: ES
authors.lastname: Jordanova
authors.forename: Sergiu
authors.initials: S
authors.lastname: Ungureanu
authors.forename: Els
authors.initials: E
authors.lastname: Berns
authors.forename: Xavier
authors.initials: X
authors.lastname: Sastre
mesh_terms: D052685:Alphapapillomavirus / Q000235:genetics / Q000302:isolation & purification*; D014408:Biomarkers, Tumor / Q000032:analysis; D005260:Female; D006801:Humans; D012333:RNA, Messenger / Q000235:genetics; D002578:Uterine Cervical Dysplasia / Q000821:virology*; D002583:Uterine Cervical Neoplasms / Q000821:virology*
chemical_list: D014408:Biomarkers, Tumor; D012333:RNA, Messenger