title: Stereochemical assignment of five new lignan glycosides from Viscum album by NMR study combined with CD spectroscopy.
abstract: The chemical study of the leaves and twigs of Viscum album led to the isolation of five new lignan glycosides, namely, ligalbumosides A-E (2-6) and one known lignan glycoside, alangilignoside C (1). The structures of five new lignan glycosides were determined to be (7R,8S,8'S)-4,9,4'-trihydroxy-3,5,3',5'-tetramethoxy-7,9'-epoxylignan 9-O-β-D-glucopyranoside (2), (7S,8S,7'S,8'R)-4,9,4'-trihydroxy-3,5,3',5',7'-pentamethoxy-7,9'-epoxylignan 9-O-β-D-glucopyranoside (3), (7R,8R,7'S,8'S)-4,9,4'-trihydroxy-3,5,3',5',7'-pentamethoxy-7,9'-epoxylignan 9-O-β-D-glucopyranoside (4), (7S,8R,7'S,8'R)-4,9,4'-trihydroxy-3,5,3',5',7'-pentamethoxy-7,9'-epoxylignan 9-O-β-D-glucopyranoside (5), and (7R,8S,7'R,8'S)-4,9,4',7'-tetrahydroxy-3,5,3',5'-tetramethoxy-7,9'-epoxylignan 9-O-β-D-glucopyranoside (6) using 1D-, 2D-NMR, and CD spectra, chemical methods, as well as comparing the results with those reported in the literature.
authors.affiliation: College of Pharmacy, Yonsei Institute of Pharmaceutical Sciences, Yonsei University, Incheon, Korea.
authors.forename: Nguyen Xuan
authors.initials: NX
authors.lastname: Nhiem
authors.forename: Hwa Young
authors.initials: HY
authors.lastname: Lee
authors.forename: Nan Young
authors.initials: NY
authors.lastname: Kim
authors.forename: Seon Ju
authors.initials: SJ
authors.lastname: Park
authors.forename: Eun Sil
authors.initials: ES
authors.lastname: Kim
authors.forename: Jeong Eun
authors.initials: JE
authors.lastname: Han
authors.forename: Heejung
authors.initials: H
authors.lastname: Yang
authors.forename: Seung Hyun
authors.initials: SH
authors.lastname: Kim
mesh_terms: D002942:Circular Dichroism; D006027:Glycosides / Q000737:chemistry*; D008024:Ligands; D009682:Magnetic Resonance Spectroscopy / Q000592:standards; D008968:Molecular Conformation; D012015:Reference Standards; D013237:Stereoisomerism; D028182:Viscum album / Q000737:chemistry*
chemical_list: D006027:Glycosides; D008024:Ligands