title: Iridium-catalyzed alkylation of methylquinolines with alcohols.
abstract: Iridium-catalyzed alkylation of methylquinolines at the methyl substituent was achieved using alcohols as alkylating agents. The reaction proceeded through a transfer hydrogenation pathway from the alcohol to the Ir complex, affording an aldehyde and Ir-H species, followed by base-assisted aldol condensation and hydrogenation. This method provides an atom-economical and convenient route to alkylquinolines from easily accessible methylquinolines.
authors.affiliation: Department of Chemistry and Materials Engineering, Faculty of Chemistry, Materials and Bioengineering, Kansai University, Suita, Osaka 564-8680, Japan. obora@kansai-u.ac.jp
authors.forename: Yasushi
authors.initials: Y
authors.lastname: Obora
authors.forename: Shinji
authors.initials: S
authors.lastname: Ogawa
authors.forename: Nobuyuki
authors.initials: N
authors.lastname: Yamamoto
mesh_terms: D000438:Alcohols / Q000737:chemistry*; D000478:Alkylation; D002384:Catalysis; D006865:Hydrogenation; D007495:Iridium / Q000737:chemistry*; D015394:Molecular Structure; D009942:Organometallic Compounds / Q000737:chemistry*; D011804:Quinolines / Q000138:chemical synthesis / Q000737:chemistry*
chemical_list: D000438:Alcohols; D009942:Organometallic Compounds; D011804:Quinolines; D007495:Iridium