title: Use of canine small intestinal submucosa allograft for treating perineal hernias in two dogs.
abstract: Here, we describe two dogs in which canine small intestinal submucosa (SIS) was implanted as a biomaterial scaffold during perineal herniorrhaphy. Both dogs had developed severe muscle weakness, unilaterally herniated rectal protrusions, and heart problems with potential anesthetic risks. Areas affected by the perineal hernia (PH) located between the internal obturator and external anal sphincter muscles were reconstructed with naïve canine SIS sheets. In 12 months, post-operative complications such as wound infections, sciatic paralysis, rectal prolapse, or recurrence of the hernia were not observed. Symptoms of defecatory tenesmus also improved. Neither case showed any signs of rejection or specific immune responses as determined by complete and differential cell counts. Our findings demonstrate that canine SIS can be used as a biomaterial scaffold for PH repair in dogs.
authors.affiliation: Department of Veterinary Surgery, College of Veterinary Medicine, Konkuk University, Seoul 143-701, Korea.
authors.forename: A-Jin
authors.initials: AJ
authors.lastname: Lee
authors.forename: Wook-Hun
authors.initials: WH
authors.lastname: Chung
authors.forename: Dae-Hyun
authors.initials: DH
authors.lastname: Kim
authors.forename: Kyung-Pil
authors.initials: KP
authors.lastname: Lee
authors.forename: Hyun Jung
authors.initials: HJ
authors.lastname: Suh
authors.forename: Sun Hee
authors.initials: SH
authors.lastname: Do
authors.forename: Ki-Dong
authors.initials: KD
authors.lastname: Eom
authors.forename: Hwi-Yool
authors.initials: HY
authors.lastname: Kim
mesh_terms: D000818:Animals; D001672:Biocompatible Materials; D004283:Dog Diseases / Q000601:surgery*; D004285:Dogs; D046449:Hernia, Abdominal / Q000601:surgery / Q000662:veterinary*; D059685:Herniorrhaphy / Q000662:veterinary; D007413:Intestinal Mucosa / Q000637:transplantation*; D007421:Intestine, Small / Q000637:transplantation*; D008297:Male; D010502:Perineum / Q000601:surgery; D011183:Postoperative Complications / Q000662:veterinary; D014184:Transplantation, Homologous / Q000662:veterinary
chemical_list: D001672:Biocompatible Materials