title: Antigen presenting cells costimulatory signaling during pre-implantation pregnancy.
abstract: Success of pregnancy depends on many factors. Three phenomena inducing immune tolerance against semi-allogeneic conceptus may play a crucial role in the pre-implantation period of pregnancy: influence of sex hormones in sex cycle, presence of oocyte or embryo and the presence of semen in the female reproductive tract. On the other hand dendritic cells are the most effective antigen-presenting cells in regulation of immune phenomena and also are considered as potent participants in inducing immune tolerance in the pregnancy. They communicate with T cells in cell contact-dependent manner or via cytokines. During cell-cell contacts, costimulatory molecules play a key role and their expression is often dependent on cytokines milieu. Both costimulatory molecules and cytokines influence generation of T regulatory cells. Interactions of these molecules are closely related. In this paper we would like to pay attention to the importance of antigen presenting cells costimulatory potency in immune regulation during a pre-implantation period of pregnancy.
authors.affiliation: Ludwik Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Laboratory of Reproductive Immunology, R. Weigla Str. 12, 53-114 Wrocław, Poland.
authors.forename: Anna
authors.initials: A
authors.lastname: Sławek
authors.forename: Tomasz
authors.initials: T
authors.lastname: Maj
authors.forename: Anna
authors.initials: A
authors.lastname: Chełmonska-Soyta
mesh_terms: D000938:Antigen-Presenting Cells / Q000276:immunology*; D015703:Antigens, CD / Q000276:immunology*; D002450:Cell Communication / Q000276:immunology; D016207:Cytokines / Q000276:immunology; D003713:Dendritic Cells / Q000276:immunology; D047108:Embryonic Development / Q000276:immunology*; D005260:Female; D006728:Hormones / Q000378:metabolism; D006801:Humans; D007108:Immune Tolerance / Q000276:immunology*; D036341:Intercellular Signaling Peptides and Proteins; D007376:Interleukin-2; D008214:Lymphocytes / Q000276:immunology; D011247:Pregnancy / Q000276:immunology*; D020239:Receptor Cross-Talk / Q000276:immunology; D012661:Semen / Q000276:immunology; D015398:Signal Transduction / Q000276:immunology
chemical_list: D015703:Antigens, CD; D016207:Cytokines; D006728:Hormones; D036341:Intercellular Signaling Peptides and Proteins; D007376:Interleukin-2