title: Cheap, suitable, predictable and manageable nanoparticles for drug delivery: quantum dots.
abstract: Recently ZnO quantum dots are reported to be very promising for drug delivery. It has also been reported that adsorptive material can deliver drug molecules by simple adsorption and they release the drug at site of action by subsequent desorption. This has been shown for carbon nanotubes and some other hydrophobic molecules for transdermal applications in the literature. Therefore it was aimed to find the effect of ZnO quantum dots on transdermal penetrations of selected model drug molecules (ketoprofen and dexketoperofen). Drug coated ZnO quantum dots were found to increase transdermal penetration of ketoprofen and dexketoprofen through rat skin.
authors.affiliation: Department of Pharmaceutical Technology, Faculty of Pharmacy, Gazi University, 06330 Etiler, Ankara, Turkey. tdegim@gazi.edu.tr
authors.forename: Ismail Tuncer
authors.initials: IT
authors.lastname: Degim
authors.forename: Demet
authors.initials: D
authors.lastname: Kadioglu
mesh_terms: D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage*; D004337:Drug Carriers / Q000008:administration & dosage* / Q000737:chemistry; D066298:In Vitro Techniques; D007660:Ketoprofen / Q000008:administration & dosage* / Q000031:analogs & derivatives; D045663:Quantum Dots; D051381:Rats; D012869:Skin Absorption; D014325:Tromethamine / Q000008:administration & dosage; D015034:Zinc Oxide / Q000008:administration & dosage* / Q000737:chemistry
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D004337:Drug Carriers; D014325:Tromethamine; D007660:Ketoprofen; C118296:dexketoprofen trometamol; D015034:Zinc Oxide