title: [Immunoregulatory effect of artesunate on allergic contact dermatitis and its mechanism].
abstract: This study is to elucidate the immunoregulation mechanisms of artesunate (AST) on allergic contact dermatitis (ACD). Pharmacodynamics analyses, HE staining, semi-quantitative RT-PCR and Western blotting were used to explore the effects of AST on the related cytokines, transcription factor and signaling molecule of ACD respectively. The results indicated that topical administration of AST not only reduced the increase of ear swelling, spleen index and inflammatory cells infiltration in ACD mice, but also inhibited remarkably the expression of IFN-gamma, T-bet and NF-kappaB p65. It's suggested that AST could exhibit suppressive effects on inflammatory response and immune function of ACD, which indicates the possibility of developing AST as a novel immunoregulatory agent in the treatment of ACD and other immune-related diseases.
authors.affiliation: Department of Immunology, Logistics University of the Chinese People's Armed Police Force, Tianjin 300162, China.
authors.forename: Tan
authors.initials: T
authors.lastname: Li
authors.forename: Hong
authors.initials: H
authors.lastname: Chen
authors.forename: Xiao-Guang
authors.initials: XG
authors.lastname: Liu
authors.forename: Ya-Xun
authors.initials: YX
authors.lastname: Zhou
authors.forename: Shu-Fang
authors.initials: SF
authors.lastname: Bai
mesh_terms: D000287:Administration, Topical; D000818:Animals; D037621:Artemisinins / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology*; D000077332:Artesunate; D017449:Dermatitis, Allergic Contact / Q000276:immunology / Q000378:metabolism* / Q000473:pathology; D004423:Ear / Q000473:pathology; D005260:Female; D050990:GATA3 Transcription Factor / Q000235:genetics / Q000378:metabolism; D006968:Hypersensitivity, Delayed / Q000188:drug therapy; D007166:Immunosuppressive Agents / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology*; D007371:Interferon-gamma / Q000235:genetics / Q000378:metabolism; D015847:Interleukin-4 / Q000235:genetics / Q000378:metabolism; D051379:Mice; D008813:Mice, Inbred ICR; D015394:Molecular Structure; D016328:NF-kappa B / Q000378:metabolism; D012333:RNA, Messenger / Q000378:metabolism; D020825:T-Box Domain Proteins / Q000235:genetics / Q000378:metabolism; D000098815:T-bet Transcription Factor
chemical_list: D037621:Artemisinins; D050990:GATA3 Transcription Factor; C494748:Gata3 protein, mouse; D007166:Immunosuppressive Agents; D016328:NF-kappa B; D012333:RNA, Messenger; D020825:T-Box Domain Proteins; D000098815:T-bet Transcription Factor; D015847:Interleukin-4; D000077332:Artesunate; D007371:Interferon-gamma