title: [Three pediatric cases of group A coxsackievirus-associated encephalitis/encephalopathy].
abstract: We report three pediatric cases of group A coxsackievirus-associated encephalitis/encephalopathy. A 4-year-old girl with coxsackievirus A6 infection presented with an exanthem on her upper body on the fourth day of fever. The following day, she developed an episode of convulsions, and subsequently experienced sudden cardiopulmonary arrest. A head computed tomography scan revealed severe brain edema. Two patients with neurological sequelae had initially presented with status epilepticus that required intravenous barbiturate treatment. Both cases had high-signal-intensity lesions on their diffusion-weighted brain magnetic resonance images. A 5-year-old girl with subcortical white matter lesions was diagnosed with acute encephalopathy with febrile convulsive status epilepticus, and a 2-year-old boy with bilateral hippocampal lesions was diagnosed with parainfectious limbic encephalitis. These findings indicate that group A coxsackievirus is a causative agent of pediatric encephalitis/encephalopathy; moreover, the prognosis may be poor in some cases.
authors.affiliation: Department of Pediatric Neurology, Shimada Ryoiku Center Hachioji, Hachioji, Tokyo. k.aizaki@shimada-ryoiku.or.jp
authors.forename: Koichi
authors.initials: K
authors.lastname: Aizaki
authors.forename: Tomohiko
authors.initials: T
authors.lastname: Tsuru
authors.forename: Keiko
authors.initials: K
authors.lastname: Okumura
authors.forename: Noriko
authors.initials: N
authors.lastname: Kondo
mesh_terms: D001927:Brain Diseases / Q000209:etiology*; D002675:Child, Preschool; D003384:Coxsackievirus Infections / Q000150:complications*; D018792:Encephalitis, Viral / Q000209:etiology*; D005260:Female; D006801:Humans; D008297:Male