title: Short- and long-term effects of various Citrullus colocynthis seed extracts             in normal and streptozotocin-induced diabetic rats.
abstract: In the light of previous findings, the major aim of the present study was             to investigate the potential beneficial effects of various Citrullus colocynthis             L. seed extracts on such variables as glucose tolerance, body weight gain, pancreas,             liver, kidney, testis, epididymal fat and diaphragm muscle weight, as well as             serum cholesterol, triglyceride, urea, creatinine, transaminases and alkaline             phosphatase concentrations in an animal model of type-1 diabetes mellitus, i.e.             streptozotocin-induced diabetic rats. For purpose of comparison, a comparable             study was conducted in normal rats. Both the immediate and long-term effects of             the plant extracts were assessed in rats injected daily, up to 3 weeks after the             start of the experiments. The results of this study reinforce the view that both             a crude aqueous extract and a n-butanol extract from the Citrullus colocynthis             L. seeds may represent the best candidates in order to eventually identify a component             suitable for the treatment of both type-1 and type-2 diabetic subjects.
authors.affiliation: Laboratory of Antibiotic and Antifungal Physico-Chemistry, Synthesis                     and Biological Activity, Faculté des Sciences, University Abou Bekr Belakaïd,                     Tlemcen, Algeria.
authors.forename: Nabila
authors.initials: N
authors.lastname: Benariba
authors.forename: Rabeh
authors.initials: R
authors.lastname: Djaziri
authors.forename: Bouchra Hanane
authors.initials: BH
authors.lastname: Zerriouh
authors.forename: Wafaa
authors.initials: W
authors.lastname: Bellakhdar
authors.forename: Emeline
authors.initials: E
authors.lastname: Hupkens
authors.forename: Zahia
authors.initials: Z
authors.lastname: Boucherit
authors.forename: Willy J
authors.initials: WJ
authors.lastname: Malaisse
mesh_terms: D000818:Animals; D001786:Blood Glucose; D001835:Body Weight / Q000187:drug effects; D002784:Cholesterol / Q000097:blood; D029773:Citrullus / Q000737:chemistry*; D003921:Diabetes Mellitus, Experimental / Q000097:blood / Q000188:drug therapy*; D007004:Hypoglycemic Agents / Q000008:administration & dosage* / Q000302:isolation & purification; D007274:Injections, Intraperitoneal; D008099:Liver / Q000187:drug effects / Q000473:pathology; D008297:Male; D009929:Organ Size / Q000187:drug effects; D010936:Plant Extracts / Q000008:administration & dosage* / Q000302:isolation & purification; D051381:Rats; D017208:Rats, Wistar; D012639:Seeds / Q000737:chemistry*; D013311:Streptozocin; D014280:Triglycerides / Q000097:blood
chemical_list: D001786:Blood Glucose; D007004:Hypoglycemic Agents; D010936:Plant Extracts; D014280:Triglycerides; D013311:Streptozocin; D002784:Cholesterol