title: A facile synthesis of novel bis-(indolyl)-1,3,4-oxadiazoles as potent cytotoxic agents.
abstract: A recipe for potency: A novel series of bis(indolyl)-1,3,4-oxadiazoles was prepared from the corresponding hydrazide-hydrazones via iodobenzene diacetate-promoted oxidative cyclization. Evaluation against a panel of human cancer cell lines revealed that some derivatives possess potent cytotoxicity with tunable selectivity for different cancer types.
authors.affiliation: Department of Chemistry, Birla Institute of Technology and Science, Pilani-333031, Rajasthan (India). dalipk@bits-pilani.ac.in.
authors.forename: Dalip
authors.initials: D
authors.lastname: Kumar
authors.forename: V
authors.initials: V
authors.lastname: Arun
authors.forename: N
authors.initials: N
authors.lastname: Maruthi Kumar
authors.forename: Glen
authors.initials: G
authors.lastname: Acosta
authors.forename: Brett
authors.initials: B
authors.lastname: Noel
authors.forename: Kavita
authors.initials: K
authors.lastname: Shah
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D045744:Cell Line, Tumor; D003603:Cytotoxins / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D007211:Indoles / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D009369:Neoplasms / Q000188:drug therapy; D010069:Oxadiazoles / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D000970:Antineoplastic Agents; D003603:Cytotoxins; D007211:Indoles; D010069:Oxadiazoles