title: Specific frequency bands of amplitude low-frequency oscillation encodes personality.
abstract: The biological model of extraversion and neuroticism identified by Eysenck has stimulated increasing interest in uncovering neurobiological substrate of the two fundamental dimensions. Here we aim to explore brain disturbances underlying extraversion and neuroticism in 87 healthy individuals using fractional amplitude of low-frequency fluctuations (LFF) on resting-state functional magnetic resonance imaging. Two different frequency bands, Slow-5 (0.01-0.027 Hz) exhibiting higher power and involving larger brain regions, and Slow-4 (0.027-0.073 Hz) exhibiting less power and emerging locally, were analyzed. Our results showed a positive correlation between LFF amplitude at Slow-5 and extraversion in medial prefrontal cortex and precuneus, important portions of the default mode network, thus suggesting a link between default network activity and personality traits. LFF amplitude at Slow-5 was correlated positively with neuroticism in right posterior portion of the frontal lobe, further validating neuroticism with frontal lateralization. In addition, LFF amplitude at Slow-4 was negatively associated with extraversion and neuroticism in left hippocampus (HIP) and bilateral superior temporal cortex (STC) respectively, supporting the hypothesized (inverse) relationship between extraversion and resting arousal, also implying neural circuit underlying emotional process influencing on personality. Overall, these findings suggest the important relationships, between personality and LFF amplitude dynamic, depend on specific frequency bands.
authors.affiliation: Key Laboratory for Neuroinformation of Ministry of Education, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, People's Republic of China.
authors.forename: Luqing
authors.initials: L
authors.lastname: Wei
authors.forename: Xujun
authors.initials: X
authors.lastname: Duan
authors.forename: Chunyan
authors.initials: C
authors.lastname: Zheng
authors.forename: Shanshan
authors.initials: S
authors.lastname: Wang
authors.forename: Qing
authors.initials: Q
authors.lastname: Gao
authors.forename: Zhiqiang
authors.initials: Z
authors.lastname: Zhang
authors.forename: Guangming
authors.initials: G
authors.lastname: Lu
authors.forename: Huafu
authors.initials: H
authors.lastname: Chen
mesh_terms: D000293:Adolescent; D000328:Adult; D001008:Anxiety Disorders / Q000503:physiopathology*; D001921:Brain / Q000502:physiology*; D001931:Brain Mapping; D005120:Extraversion, Psychological; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging; D008297:Male; D000075384:Neuroticism; D010551:Personality / Q000502:physiology; D012146:Rest / Q000502:physiology; D011795:Surveys and Questionnaires; D055815:Young Adult