title: Case of endogenous endophthalmitis caused by Klebsiella pneumoniae with magA and rmpA genes in an immunocompetent patient.
abstract: We report a case of endogenous endophthalmitis caused by Klebsiella pneumoniae in an immunocompetent patient. A 73-year-old man with acute epididymitis who had no history of diabetes mellitus developed endogenous endophthalmitis. The patient underwent anterior vitrectomy and intracapsular cataract extraction with intravitreal injections of both vancomycin and ceftazidime. After the surgery, he was treated with topical and intravenous antibiotics; however, the left eye perforated and was enucleated. Culture from vitreous biopsy specimens grew as K. pneumoniae, which was positive for both magA and rmpA. K. pneumoniae should be considered as a pathogen that can cause severe endogenous endophthalmitis in patients with urinary tract infection. The severity of the disease may be related to the virulence genes.
authors.affiliation: Department of Ophthalmology, Gifu University Graduate School of Medicine, 1-1 Yanagido, Gifu, Japan. sawadaa-gif@umin.ac.jp
authors.forename: Akira
authors.initials: A
authors.lastname: Sawada
authors.forename: Shinya
authors.initials: S
authors.lastname: Komori
authors.forename: Kazunari
authors.initials: K
authors.lastname: Udo
authors.forename: Shinsuke
authors.initials: S
authors.lastname: Suemori
authors.forename: Kiyofumi
authors.initials: K
authors.lastname: Mochizuki
authors.forename: Mitsuru
authors.initials: M
authors.lastname: Yasuda
authors.forename: Kiyofumi
authors.initials: K
authors.lastname: Ohkusu
mesh_terms: D000368:Aged; D000900:Anti-Bacterial Agents / Q000494:pharmacology / Q000627:therapeutic use; D001426:Bacterial Proteins / Q000235:genetics*; D009877:Endophthalmitis / Q000188:drug therapy / Q000276:immunology / Q000382:microbiology* / Q000601:surgery; D004823:Epididymitis / Q000150:complications / Q000188:drug therapy; D015353:Eye Enucleation; D006801:Humans; D016867:Immunocompromised Host; D007710:Klebsiella Infections / Q000188:drug therapy / Q000276:immunology / Q000382:microbiology* / Q000601:surgery; D007711:Klebsiella pneumoniae / Q000187:drug effects / Q000235:genetics* / Q000302:isolation & purification / Q000472:pathogenicity; D008297:Male; D008826:Microbial Sensitivity Tests
chemical_list: D000900:Anti-Bacterial Agents; D001426:Bacterial Proteins; C501254:MagA protein, Klebsiella pneumoniae; C512267:RmpA protein, Klebsiella pneumoniae