title: Effect of statins on skeletal muscle:  exercise, myopathy, and muscle outcomes.
abstract: Statins are effective in reducing low-density lipoprotein cholesterol and cardiac events but can produce muscle side effects. We have hypothesized that statin-related muscle complaints are exacerbated by exercise and influenced by factors including mitochondrial dysfunction, membrane disruption, and/or calcium handling. The interaction between statins, exercise, and muscle symptoms may be more effectively diagnosed and treated as rigorous scientific studies accumulate.
authors.affiliation: Division of Cardiology, Henry Low Heart Center, Hartford Hospital, Hartford, CT 06012, USA. bparker03@harthosp.org
authors.forename: Beth A
authors.initials: BA
authors.lastname: Parker
authors.forename: Paul D
authors.initials: PD
authors.lastname: Thompson
mesh_terms: D000818:Animals; D015444:Exercise; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000009:adverse effects*; D018482:Muscle, Skeletal / Q000187:drug effects*; D009135:Muscular Diseases / Q000139:chemically induced*
chemical_list: D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors