title: Two young-adult female cases of dermatomyositis with antibodies for transcriptional intermediary factor 1-γ.
abstract: A variety of myositis-specific autoantibodies (MSAs) have been detected in patients with dermatomyositis (DM). We analyzed MSAs in 20 cases with DM. Eleven of the 20 cases were positive. Out of those 11 cases, 3 were positive for antibodies against aminoacyl-tRNA synthetase and 3 had antibodies to anti-melanoma differentiation-associated gene 5 detected using an immunoprecipitation assay and/or a specific enzyme-linked immunosorbent assay. One case had anti-NXP-2 antibodies and 4 cases had anti-transcriptional intermediary factor 1 (TIF1)-α/γ antibodies detected by immunoprecipitation and Western blotting. Two of those 4 cases had antibodies for both TIF1-α and TIF1-γ, and the 2 other cases had antibodies for TIF1-γ alone. We report the 2 cases with antibodies for TIF1-γ only, who were young-adult females without an internal malignancy or interstitial pneumonia. Those 2 cases had clinically amyopathic DM. Among DM patients with antibodies against TIF1 family proteins, there seems to be a subgroup of young-adult cases who have clinically amyopathic DM and show good prognosis without malignancy.
authors.affiliation: Department of Dermatology, Tokyo Women's Medical University, 8-1 Kawada-cho, Shinjuku-ku, Tokyo 162-8666, Japan.
authors.forename: Eri
authors.initials: E
authors.lastname: Matsuura
authors.forename: Naoko
authors.initials: N
authors.lastname: Ishiguro
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Katsumata
authors.forename: Wako
authors.initials: W
authors.lastname: Urano
authors.forename: Hisashi
authors.initials: H
authors.lastname: Yamanaka
authors.forename: Mitsuko
authors.initials: M
authors.lastname: Kondo
authors.forename: Masataka
authors.initials: M
authors.lastname: Kuwana
authors.forename: Kenzo
authors.initials: K
authors.lastname: Kaji
authors.forename: Yasuhito
authors.initials: Y
authors.lastname: Hamaguchi
authors.forename: Manabu
authors.initials: M
authors.lastname: Fujimoto
authors.forename: Makoto
authors.initials: M
authors.lastname: Kawashima
mesh_terms: D000251:Adenosine Triphosphatases / Q000276:immunology; D000328:Adult; D000368:Aged; D000604:Amino Acyl-tRNA Synthetases / Q000276:immunology; D001323:Autoantibodies / Q000097:blood*; D053487:DEAD-box RNA Helicases / Q000276:immunology; D004268:DNA-Binding Proteins / Q000276:immunology; D003882:Dermatomyositis / Q000276:immunology* / Q000473:pathology; D005260:Female; D006801:Humans; D000072640:Interferon-Induced Helicase, IFIH1; D008297:Male; D008875:Middle Aged; D009687:Nuclear Proteins / Q000276:immunology; D014157:Transcription Factors / Q000276:immunology*; D055815:Young Adult
chemical_list: D001323:Autoantibodies; D004268:DNA-Binding Proteins; D009687:Nuclear Proteins; C511956:TRIM33 protein, human; D014157:Transcription Factors; C093517:transcriptional intermediary factor 1; D000251:Adenosine Triphosphatases; C452815:IFIH1 protein, human; C551732:MORC3 protein, human; D053487:DEAD-box RNA Helicases; D000072640:Interferon-Induced Helicase, IFIH1; D000604:Amino Acyl-tRNA Synthetases