title: Associations between genetic polymorphisms of beta-2 adrenergic receptor and preterm delivery in Korean women.
abstract: OBJECTIVE
  We investigated genetic polymorphisms to understand the etiology of preterm delivery, which involves inflammatory cytokines and uterine contraction. Maternal polymorphisms of ADRB2, iNOS, and eNOS were examined, and associations between these and the risk of preterm delivery were sought.
  
  
  METHODS
  This study was performed on 166 Korean women who underwent preterm delivery and 289 normal controls. Logistic regression analyses were carried out to identify single genes and haplotypes that affect the risk of preterm delivery.
  
  
  RESULTS
  The G/G haplotype of ADRB2-rs1042713 and -rs1042714 was found to be associated with the risk of preterm delivery (OR = 1.90, 95% CI = 1.08-3.33, P-value = 0.0252). The genotype frequency of G allele in ADRB2-rs1042714 was associated with increased the risk of preterm delivery. However, after the adjustment of multiple comparison corrections, the association with preterm delivery was not remained significantly.
  
  
  CONCLUSIONS
  These findings possibly aid our understanding of the pathogenesis of preterm delivery and suggest that a haplotype with variants in maternal genes involved in adrenergic activation may lead to the dysregulation of uterine contractility and increase the risk of preterm delivery.
authors.affiliation: Department of Clinical Research, School of Medicine, Inha University, Incheon, Korea.
authors.forename: Young Ju
authors.initials: YJ
authors.lastname: Suh
authors.forename: Hyun Ju
authors.initials: HJ
authors.lastname: Park
authors.forename: Kyung A
authors.initials: KA
authors.lastname: Lee
authors.forename: Bo Eun
authors.initials: BE
authors.lastname: Lee
authors.forename: Eun Hee
authors.initials: EH
authors.lastname: Ha
authors.forename: Young Ju
authors.initials: YJ
authors.lastname: Kim
mesh_terms: D000328:Adult; D004252:DNA Mutational Analysis; D005260:Female; D005787:Gene Frequency; D056726:Genetic Association Studies; D005838:Genotype; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D052247:Nitric Oxide Synthase Type II / Q000235:genetics; D052250:Nitric Oxide Synthase Type III / Q000235:genetics; D011110:Polymorphism, Genetic; D047928:Premature Birth / Q000235:genetics*; D018343:Receptors, Adrenergic, beta-2 / Q000235:genetics*; D056910:Republic of Korea; D012306:Risk; D014590:Uterine Contraction / Q000235:genetics
chemical_list: D018343:Receptors, Adrenergic, beta-2; D052247:Nitric Oxide Synthase Type II; D052250:Nitric Oxide Synthase Type III