title: Multifocal metachronous giant cell tumour in bilateral upper limb: a rare case presentation.
abstract: Giant cell tumour (GCT) of bone is a benign but locally aggressive tumour and accounts for 20 % of all benign bone tumours and 5 % of all bone tumours. Multicentric GCT of bone is a rare entity and has increased prevalence of involvement of the small bones of hands and feet in multicentric GCT. The clinical behaviour in multicentric GCTs tends to be aggressive as in recurrent GCTs. En-bloc resection remains the most successful surgical technique for treating both multicentric and solitary lesions. We report a 14-year-old female patient presenting with metachronous benign GCT located at the right proximal humerus and subsequent lesions in left hand and left proximal humerus. The case was treated with multimodality therapy including en-bloc resection along with bisphosphonate therapy over a period of 5 years.
authors.affiliation: Department of Orthopaedics, All India Institute of Medical Sciences, room no. 105, hostel no. 8, AIIMS, New Delhi, 110029, India.
authors.forename: Vivek
authors.initials: V
authors.lastname: Morey
authors.forename: Sukesh Rao
authors.initials: SR
authors.lastname: Sankineani
authors.forename: Ramakant
authors.initials: R
authors.lastname: Kumar
mesh_terms: D000293:Adolescent; D001859:Bone Neoplasms / Q000473:pathology* / Q000628:therapy; D003131:Combined Modality Therapy; D005260:Female; D018212:Giant Cell Tumor of Bone / Q000473:pathology* / Q000628:therapy; D006801:Humans; D006811:Humerus; D016609:Neoplasms, Second Primary / Q000473:pathology* / Q000628:therapy