title: [Pharmacokinetics of Danshen multi-component osmotic pump tablets in Beagle dogs].
abstract: OBJECTIVE
  To study the variation in plasma concentration after oral administration of Danshen multi-component osmotic pump tablets in Beagle dogs with conventional Danshen tablets as the control preparation, in order to assess the sustained release of Danshen multi-component osmotic pump tablets.
  
  
  METHODS
  HPLC was adopted for determination, with Shimadzu's ODS-SP column (4.6 mm x 150 mm, 5 microm), flow rate of 1 mL x min(-1), and column temperature of 30 degrees C. Protein in plasma samples of tanshinone II(A) and salvianolic acid B was removed by ethyl acetate extract and acetone precipitation method respectively. Their pharmacokinetic parameters were calculated based on determination results.
  
  
  RESULTS
  The methodology study on the two constituents with different polarity showed conformity to the requirements. Compared with conventional Danshen tablets, Danshen multi-component osmotic pump tablets showed decrease in Cmax and extension in Tmax after oral administration in Beagle dogs.
  
  
  CONCLUSIONS
  Danshen multi-component osmotic pump tablet has a good sustained-release effect compared with conventional Danshen tablets.
authors.affiliation: Beijing University of Chinese Medicine, Beijing 100102, China. zhoulin1211@163.com
authors.forename: Lin
authors.initials: L
authors.lastname: Zhou
authors.forename: Xianying
authors.initials: X
authors.lastname: Liu
authors.forename: Jinfeng
authors.initials: J
authors.lastname: Zheng
authors.forename: Qing
authors.initials: Q
authors.lastname: Wu
authors.forename: Shouying
authors.initials: S
authors.lastname: Du
mesh_terms: D000818:Animals; D004285:Dogs; D004365:Drugs, Chinese Herbal / Q000493:pharmacokinetics*; D008297:Male; D009995:Osmosis; D027561:Salvia miltiorrhiza / Q000737:chemistry*; D013607:Tablets; D013997:Time Factors
chemical_list: D004365:Drugs, Chinese Herbal; D013607:Tablets