title: External heavy-atomic construction of photosensitizer nanoparticles for enhanced in vitro photodynamic therapy of cancer.
abstract: Introduction of heavy atoms around photosensitizers (PSs) generally facilitates intersystem crossing (ISC) and improves their quantum yield of singlet oxygen ((1)O(2)) generation ability, which is a key species in photodynamic therapy (PDT). Here, we report Pt(IV)- and Au(III)-modified silica nanoparticles (SN) as the drug delivery system of a hypocrellin A (HA) to improve its photodynamic activity through external heavy atom effect. Comparative studies with Pt- and Au-modified and unmodified nanoparticles have demonstrated that the intraparticle external heavy atom effect on the encapsulated HA molecules significantly enhances their efficiency of (1)O(2) generation and, thereby, the in vitro photodynamic efficacy to cancer cells. The results well elucidated the potential of our PSs/heavy metal ions doped nanocarrier for improving the actual efficacy of PDT.
authors.affiliation: Analysis and Testing Center, College of Chemistry and Materials Science, Jiangsu Key Laboratory Biofunctional Materials, Nanjing Normal University, Nanjing 210046, China.
authors.forename: Lin
authors.initials: L
authors.lastname: Zhou
authors.forename: Shaohua
authors.initials: S
authors.lastname: Wei
authors.forename: Xuefeng
authors.initials: X
authors.lastname: Ge
authors.forename: Jiahong
authors.initials: J
authors.lastname: Zhou
authors.forename: Boyang
authors.initials: B
authors.lastname: Yu
authors.forename: Jian
authors.initials: J
authors.lastname: Shen
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry / Q000494:pharmacology*; D016923:Cell Death / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D016503:Drug Delivery Systems; D006046:Gold / Q000737:chemistry; D006367:HeLa Cells; D006801:Humans; D053758:Nanoparticles / Q000737:chemistry*; D009369:Neoplasms / Q000188:drug therapy* / Q000473:pathology; D010569:Perylene / Q000031:analogs & derivatives* / Q000737:chemistry / Q000494:pharmacology; D019800:Phenol; D010778:Photochemotherapy; D017319:Photosensitizing Agents / Q000737:chemistry*; D010984:Platinum / Q000737:chemistry; D011809:Quinones / Q000737:chemistry / Q000494:pharmacology*; D012822:Silicon Dioxide / Q000737:chemistry*; D026082:Singlet Oxygen / Q000737:chemistry; D013329:Structure-Activity Relationship; D014407:Tumor Cells, Cultured
chemical_list: D000970:Antineoplastic Agents; D017319:Photosensitizing Agents; D011809:Quinones; D026082:Singlet Oxygen; D019800:Phenol; D010984:Platinum; D010569:Perylene; D006046:Gold; D012822:Silicon Dioxide; C048388:hypocrellin A