title: [Experimental bacterial contamination of bile and liver in mongrel dogs: an alternative treatment with cephalone, a hybrid of cephalosporine fluoroquinolone].
abstract: OBJECTIVE
  A longitudinal, randomized, single blind study was done to evaluate the efficacy of an antibacterial hybrid molecule (beta-lactamic-fluoroquinolone) named cephalone after biliary-enteric-bypass (BEB).
  
  
  METHODS
  Four groups of mongrel dogs were operated on three consecutive periods. Cultures of bile and liver were obtained and assessed, followed by obliteration of common bile duct and BEB to groups A, B and C. Group D served as a control. Ten days later the group A received conventional treatment based on ampicillin/gentamicin and groups B and C, cephalone in two different concentration schemes during 10 consecutive days. Further samples were processed for bacteria and additional liver biopsies were obtained for histopathological analysis.
  
  
  RESULTS
  All three treatments reverted bacterial contamination in the liver and most of the bile samples were negative or showed a significant decrease in the number of colony forming units (p = 0.002). Histopathological analysis proved no lesions.
  
  
  CONCLUSIONS
  Comparison of efficacy among antibacterial treatments revealed undistinguishable efficacy in this short-term assessment of bacterial contamination after BEB in dogs. The use of cephalone could be considered as a viable treatment or prophylaxis in bacterial infections occurring after BEB. Further studies are needed to assess long-term impact of the cephalone in this setting.
authors.affiliation: Laboratorio de Cirugía Experimental, Instituto Nacional de Pediatría, México, DF.
authors.forename: Arturo
authors.initials: A
authors.lastname: Carmona-Mancilla
authors.forename: Fernando
authors.initials: F
authors.lastname: Villegas-Alvarez
authors.forename: Héctor
authors.initials: H
authors.lastname: Sumano-López
authors.forename: Luis
authors.initials: L
authors.lastname: Ocampo-Camberos
authors.forename: Beatriz Eugenia
authors.initials: BE
authors.lastname: Pérez-Guille
authors.forename: José Francisco
authors.initials: JF
authors.lastname: González Zamora
authors.forename: Rafael
authors.initials: R
authors.lastname: Coria-Jiménez
authors.forename: Rosa Eugenia
authors.initials: RE
authors.lastname: Soriano-Rosales
authors.forename: Miguel Angel
authors.initials: MA
authors.lastname: Jiménez-Bravo-Luna
authors.forename: Angélica
authors.initials: A
authors.lastname: González-Maciel
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D001424:Bacterial Infections / Q000188:drug therapy*; D001646:Bile / Q000382:microbiology*; D002511:Cephalosporins / Q000627:therapeutic use*; D004195:Disease Models, Animal; D004285:Dogs; D004338:Drug Combinations; D005260:Female; D024841:Fluoroquinolones / Q000627:therapeutic use*; D008099:Liver / Q000382:microbiology*; D008297:Male
chemical_list: D000900:Anti-Bacterial Agents; D002511:Cephalosporins; D004338:Drug Combinations; D024841:Fluoroquinolones