title: Validation of the modified allergic rhinitis and its impact on asthma (ARIA) severity classification in allergic rhinitis children: the PEDRIAL study.
abstract: BACKGROUND
  A modified allergic rhinitis and its impact on asthma (ARIA) (m-ARIA) criterion to classify the severity of allergic rhinitis (AR) has recently been validated in both treated and untreated adult patients; however, such information in children is lacking. The aim of this study was to validate this m-ARIA severity criterion, which allows for discrimination between moderate and severe AR, in a large pediatric patient sample population.
  
  
  METHODS
  The m-ARIA classification categorizes AR severity into mild (no affected items), moderate (1-3 affected items), and severe (all four affected items). We applied this modified criterion to untreated AR pediatric patients aged 6-12 years, through an observational, cross-sectional, and multicenter study. AR symptoms were assessed using the Total Four Symptom Score (T4SS), and the severity was evaluated by both ARIA severity items and visual analogue scale (VAS).
  
  
  RESULTS
  Allergic rhinitis pediatric patients (N = 1269) from 271 centers were included. Among them, 59.5% had intermittent and 40.5% persistent disease; 89.9% had moderate/severe AR using the original ARIA (o-ARIA) classification and 59.5% had moderate, while 30.5% had severe AR using the m-ARIA criterion. Using the m-ARIA, significantly higher T4SS and VAS scores were obtained when comparing severe with moderate AR.
  
  
  CONCLUSIONS
  The m-ARIA severity classification is a useful clinical tool to discriminate moderate from severe AR among untreated pediatric patients.
authors.affiliation: Unidad de Alergia, Hospital Universitario Arnau de Vilanova, Facultad de Medicina, Universidad Católica de Valencia, Valencia, Spain.
authors.forename: J
authors.initials: J
authors.lastname: Montoro
authors.forename: A
authors.initials: A
authors.lastname: Del Cuvillo
authors.forename: J
authors.initials: J
authors.lastname: Mullol
authors.forename: X
authors.initials: X
authors.lastname: Molina
authors.forename: J
authors.initials: J
authors.lastname: Bartra
authors.forename: I
authors.initials: I
authors.lastname: Dávila
authors.forename: M
authors.initials: M
authors.lastname: Ferrer
authors.forename: I
authors.initials: I
authors.lastname: Jáuregui
authors.forename: J
authors.initials: J
authors.lastname: Sastre
authors.forename: A
authors.initials: A
authors.lastname: Valero
mesh_terms: D001249:Asthma / Q000145:classification*; D002648:Child; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D008297:Male; D065631:Rhinitis, Allergic; D012221:Rhinitis, Allergic, Perennial / Q000145:classification*; D012720:Severity of Illness Index