title: Dilated phase of hypertrophic cardiomyopathy caused by two different sarcomere mutations, treated with surgical left ventricular reconstruction and cardiac resynchronization therapy with a defibrillator.
abstract: We herein report the case of a 61-year-old woman with dilated phase of hypertrophic cardiomyopathy (D-HCM) who had been diagnosed with HCM 17 years previously. On admission, her left ventricle (LV) had marked dilation, dyssynchrony with diffuse severe hypokinesis, and ventricular tachycardia. She had two mutations in the cardiac myosin binding protein-C gene, which were suspected to be the causes of the D-HCM. We performed LV reconstruction surgery and cardiac resynchronization therapy with a defibrillator for her drug-resistant severe heart failure. After surgery, her New York Heart Association class dramatically improved, and she has not been re-hospitalized since these treatments.
authors.affiliation: Department of Cardiology and Hematology, Fukushima Medical University, Japan.
authors.forename: Akihiko
authors.initials: A
authors.lastname: Sato
authors.forename: Nobuo
authors.initials: N
authors.lastname: Sakamoto
authors.forename: Katsuya
authors.initials: K
authors.lastname: Ando
authors.forename: Takashi
authors.initials: T
authors.lastname: Kaneshiro
authors.forename: Hironori
authors.initials: H
authors.lastname: Uekita
authors.forename: Koichi
authors.initials: K
authors.lastname: Sugimoto
authors.forename: Takayoshi
authors.initials: T
authors.lastname: Yamaki
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Kunii
authors.forename: Kazuhiko
authors.initials: K
authors.lastname: Nakazato
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Suzuki
authors.forename: Shu-ichi
authors.initials: S
authors.lastname: Saitoh
authors.forename: Masatomo
authors.initials: M
authors.lastname: Sato
authors.forename: Kazuaki
authors.initials: K
authors.lastname: Tamagawa
authors.forename: Takuro
authors.initials: T
authors.lastname: Arimura
authors.forename: Akinori
authors.initials: A
authors.lastname: Kimura
authors.forename: Yasuchika
authors.initials: Y
authors.lastname: Takeishi
mesh_terms: D058406:Cardiac Resynchronization Therapy; D002312:Cardiomyopathy, Hypertrophic / Q000175:diagnosis / Q000235:genetics* / Q000628:therapy*; D002352:Carrier Proteins / Q000235:genetics*; D017147:Defibrillators, Implantable; D004452:Echocardiography; D004562:Electrocardiography; D005260:Female; D006352:Heart Ventricles / Q000601:surgery*; D006801:Humans; D008875:Middle Aged; D009154:Mutation / Q000235:genetics*; D012518:Sarcomeres / Q000235:genetics; D016896:Treatment Outcome; D000099163:Myosin Binding Protein C
chemical_list: D002352:Carrier Proteins; D000099163:Myosin Binding Protein C