title: Engineering the antioxidative properties of lactic acid bacteria for improving its robustness.
abstract: Lactic acid bacteria (LAB) that are widely used in the food fermentations often encounter various environmental stresses during manufacturing and application. Improving the antioxidative properties of LAB was found to be an effective approach for increasing their general robustness. Here we review the recent progress of engineering the antioxidative properties of LAB, with focus on engineering the thiol compounds production. Engineering of the enzymes involved in oxidative stress resistance are also discussed. To further improve the industrial relevant robustness, engineering LAB at a higher control level is expected.
authors.affiliation: Institute of Microbiology, Chinese Academy of Sciences, No. 1 West Beichen Road, Chaoyang District, Beijing 100101, China.
authors.forename: Yanping
authors.initials: Y
authors.lastname: Zhang
authors.forename: Yin
authors.initials: Y
authors.lastname: Li
mesh_terms: D000975:Antioxidants / Q000378:metabolism*; D057005:Bioengineering; D001709:Biotechnology; D002374:Catalase / Q000378:metabolism; D005978:Glutathione / Q000378:metabolism; D019344:Lactic Acid / Q000378:metabolism*; D007778:Lactobacillus / Q000201:enzymology / Q000378:metabolism*; D009097:Multienzyme Complexes / Q000378:metabolism; D009247:NADH, NADPH Oxidoreductases / Q000378:metabolism; D010084:Oxidation-Reduction; D013312:Stress, Physiological; D013482:Superoxide Dismutase / Q000378:metabolism; D013879:Thioredoxins / Q000378:metabolism
chemical_list: D000975:Antioxidants; D009097:Multienzyme Complexes; D019344:Lactic Acid; D013879:Thioredoxins; D002374:Catalase; D013482:Superoxide Dismutase; C023107:NADH oxidase; D009247:NADH, NADPH Oxidoreductases; D005978:Glutathione