title: The antioxidant role of paraoxonase 1 and vitamin E in three autoimmune diseases.
abstract: OBJECTIVE
  To investigate the role of paraoxonase 1 (PON1) and vitamin E in the pathogenesis of some autoimmune diseases, and to correlate their levels with the disease activity.
  
  
  METHODS
  This randomized case control study was performed on 60 subjects: 45 patients [suffering from psoriasis, vitiligo and alopecia areata (AA) 15 patients each group] and 15 healthy controls. Venous blood and tissue biopsy were collected from each subject to estimate the levels of vitamin E and PON1.
  
  
  RESULTS
  All patients showed significantly lower levels of both PON1 and vitamin E in tissue and serum than the controls (p < 0.001).
  
  
  CONCLUSIONS
  An association between oxidative stress and pathogenesis of these autoimmune diseases is identified. Attenuation of oxidative stress might be a relevant therapeutic approach and it would be useful to recommend additional drugs with antioxidant effects in the treatment of these conditions.
authors.affiliation: Department of Dermatology, Cairo University, Cairo, Egypt.
authors.forename: R
authors.initials: R
authors.lastname: Ramadan
authors.forename: A
authors.initials: A
authors.lastname: Tawdy
authors.forename: R
authors.initials: R
authors.lastname: Abdel Hay
authors.forename: L
authors.initials: L
authors.lastname: Rashed
authors.forename: D
authors.initials: D
authors.lastname: Tawfik
mesh_terms: D000293:Adolescent; D000328:Adult; D000505:Alopecia / Q000378:metabolism*; D000975:Antioxidants / Q000378:metabolism*; D043303:Aryldialkylphosphatase / Q000378:metabolism*; D001327:Autoimmune Diseases / Q000378:metabolism; D016022:Case-Control Studies; D002648:Child; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D018384:Oxidative Stress; D011565:Psoriasis / Q000378:metabolism*; D014810:Vitamin E / Q000378:metabolism*; D014820:Vitiligo / Q000378:metabolism*; D055815:Young Adult
chemical_list: D000975:Antioxidants; D014810:Vitamin E; D043303:Aryldialkylphosphatase; C468406:PON1 protein, human