title: Treponema pallidum azithromycin resistance in Dublin, Ireland.
abstract: This study aimed to reassess rates of syphilis azithromycin resistance in Dublin. Of the 104 samples, 36 (34.6%) were positive for Treponema pallidum DNA by polymerase chain reaction. Thirty samples were analyzed for A2058G mutation, 29 samples sequenced. Of the 29 samples, 27 (93.1%) had the mutation. Azithromycin cannot be recommended for the treatment of syphilis in Dublin.
authors.affiliation: Department of Genitourinary Medicine and Infectious Diseases, St. James's Hospital, Dublin, Ireland. eavan@esatclear.ie
authors.forename: Eavan G
authors.initials: EG
authors.lastname: Muldoon
authors.forename: Anne
authors.initials: A
authors.lastname: Walsh
authors.forename: Brendan
authors.initials: B
authors.lastname: Crowley
authors.forename: Fiona
authors.initials: F
authors.lastname: Mulcahy
mesh_terms: D000328:Adult; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D017963:Azithromycin / Q000494:pharmacology*; D004269:DNA, Bacterial / Q000235:genetics; D024881:Drug Resistance, Bacterial / Q000187:drug effects / Q000235:genetics*; D005260:Female; D006801:Humans; D007494:Ireland / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D009154:Mutation; D012338:RNA, Ribosomal, 23S / Q000235:genetics; D013587:Syphilis / Q000188:drug therapy* / Q000453:epidemiology; D014210:Treponema pallidum / Q000187:drug effects*; D055815:Young Adult
chemical_list: D000900:Anti-Bacterial Agents; D004269:DNA, Bacterial; D012338:RNA, Ribosomal, 23S; D017963:Azithromycin