title: [Efficacy of azithromycin and its impact on cytokine system in urogenital infections].
abstract: Seventy five patients with urogenital chlamydial and mycoplasmic infections were enrolled in the trial. In the etiotropic therapy azithromycin was used in the standard dosage (1.0-1.5 g) depending on the infection. The treatment with azithromycin, in addition to the high eradication rates, was also evident of its effect on the cytokine levels in the patients, that was characteristic of a significant increase of the IFN-gamma level and a decrease of the IL-1beta and IL-6 levels in the blood.
authors.forename: A A
authors.initials: AA
authors.lastname: Khrianin
authors.forename: O V
authors.initials: OV
authors.lastname: Reshetnikov
authors.forename: I D
authors.initials: ID
authors.lastname: Safronov
authors.forename: A N
authors.initials: AN
authors.lastname: Trunov
authors.forename: N B
authors.initials: NB
authors.lastname: Kulikova
mesh_terms: D000328:Adult; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D017963:Azithromycin / Q000627:therapeutic use*; D002690:Chlamydia Infections / Q000097:blood / Q000188:drug therapy* / Q000276:immunology; D002692:Chlamydia trachomatis / Q000187:drug effects; D016207:Cytokines / Q000097:blood* / Q000276:immunology; D005260:Female; D006801:Humans; D007371:Interferon-gamma / Q000097:blood / Q000276:immunology; D007378:Interleukins / Q000097:blood / Q000276:immunology; D008297:Male; D008875:Middle Aged; D009175:Mycoplasma Infections / Q000097:blood / Q000188:drug therapy* / Q000276:immunology; D045704:Mycoplasma genitalium / Q000187:drug effects; D015231:Sexually Transmitted Diseases, Bacterial / Q000097:blood / Q000188:drug therapy* / Q000276:immunology; D016896:Treatment Outcome
chemical_list: D000900:Anti-Bacterial Agents; D016207:Cytokines; D007378:Interleukins; D007371:Interferon-gamma; D017963:Azithromycin