title: Dietary Nrf2 activators inhibit atherogenic processes.
abstract: Dietary Nrf2 activators increase expression of phase 2 protein genes in cells undergoing oxidative stress resulting in a lowering of oxidative stress. Oxidative stress promotes atherogenic processes through oxidizing low density lipoproteins and promotion of inflammation through activation of nuclear factor kappa B and activation of mitogen-activated protein kinases. Nrf2 activators by decreasing oxidative stress decrease the probability of developing atherosclerotic lesions.
authors.affiliation: College of Medicine, University of Saskatchewan, SK, Canada; College of Medicine, Alfaisal University, Riyadh, Saudi Arabia. bjuurlink@gmail.com
authors.forename: Bernhard H J
authors.initials: BH
authors.lastname: Juurlink
mesh_terms: D000818:Animals; D017879:Isothiocyanates; D013454:Sulfoxides; D013861:Thiocyanates / Q000494:pharmacology*
chemical_list: D017879:Isothiocyanates; D013454:Sulfoxides; D013861:Thiocyanates; C016766:sulforaphane