title: Polymorphic transporters and platinum pharmacodynamics.
abstract: Several solute carriers and ATP-binding cassette transporters have been implicated in the influx or efflux of platinum-based chemotherapeutic agents such as cisplatin, carboplatin, and oxaliplatin. Given that many of these proteins are highly polymorphic, the genetic status of these proteins could be an important contributor to the extensive interindividual pharmacokinetic variability associated with the clinical use of these agents. In this review article, we provide an updated overview of the various transporters that have shown promise in animal models or patient populations in facilitating the movement of platinum-based agents across cell membranes, and how their function is associated with drug disposition or pharmacodynamic effects.
authors.affiliation: Department of Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.
authors.forename: Jason A
authors.initials: JA
authors.lastname: Sprowl
authors.forename: Rachel A
authors.initials: RA
authors.lastname: Ness
authors.forename: Alex
authors.initials: A
authors.lastname: Sparreboom
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology*; D027682:Cation Transport Proteins / Q000235:genetics; D000079923:Copper Transporter 1; D006801:Humans; D026901:Membrane Transport Proteins / Q000235:genetics*; D027425:ATP-Binding Cassette, Sub-Family C Proteins / Q000235:genetics; D027701:Organic Cation Transport Proteins / Q000235:genetics; D017671:Platinum Compounds / Q000493:pharmacokinetics* / Q000494:pharmacology*; D020641:Polymorphism, Single Nucleotide
chemical_list: D000970:Antineoplastic Agents; D027682:Cation Transport Proteins; D000079923:Copper Transporter 1; D026901:Membrane Transport Proteins; D027425:ATP-Binding Cassette, Sub-Family C Proteins; D027701:Organic Cation Transport Proteins; D017671:Platinum Compounds; C073492:ABCC4 protein, human; C490079:SLC31A1 protein, human; C521869:SLC47A1 protein, human; C521870:SLC47A2 protein, human