title: Genotypic resistance testing creates new treatment challenges: two cases of oxacillin-susceptible methicillin-resistant Staphylococcus aureus.
abstract: Oxacillin-susceptible, mecA-positive Staphylococcus aureus isolates create a treatment challenge for the clinician. In this article, we describe two cases of bacteremia from isolates that carried the mecA gene but were susceptible to oxacillin (oxacillin-susceptible methicillin-resistant S. aureus [OS-MRSA]). DNA microarray analysis was used to characterize these isolates as a mecA-positive, clonal complex 5, pediatric strain and a mecA-positive, clonal complex 8, USA300 strain.
authors.affiliation: Division of Infectious Diseases, Oregon Health and Science University, Portland, Oregon, USA. sharffk@ohsu.edu
authors.forename: Katie A
authors.initials: KA
authors.lastname: Sharff
authors.forename: Stefan
authors.initials: S
authors.lastname: Monecke
authors.forename: Sarah
authors.initials: S
authors.lastname: Slaughter
authors.forename: Graeme
authors.initials: G
authors.lastname: Forrest
authors.forename: Chris
authors.initials: C
authors.lastname: Pfeiffer
authors.forename: Ralf
authors.initials: R
authors.lastname: Ehricht
authors.forename: Margret
authors.initials: M
authors.lastname: Oethinger
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D016470:Bacteremia / Q000382:microbiology; D001426:Bacterial Proteins / Q000235:genetics; D006801:Humans; D008297:Male; D055624:Methicillin-Resistant Staphylococcus aureus / Q000187:drug effects* / Q000235:genetics*; D046228:Microarray Analysis / Q000379:methods; D008826:Microbial Sensitivity Tests / Q000379:methods; D008875:Middle Aged; D010068:Oxacillin / Q000494:pharmacology*; D046915:Penicillin-Binding Proteins; D013203:Staphylococcal Infections / Q000382:microbiology*
chemical_list: D000900:Anti-Bacterial Agents; D001426:Bacterial Proteins; D046915:Penicillin-Binding Proteins; C487789:mecA protein, Staphylococcus aureus; D010068:Oxacillin