title: [Effect and mechanism of curcumol on angiogenesis activity of zebrafishes].
abstract: OBJECTIVE
  To conduct a preliminary study on the effect of curcumol in promoting angiogenesis activity and its mechanism in zebrafishes, in order to provide basis for clinical prescription.
  
  
  METHODS
  Zebrafishes biological model was established to, observe curcumol's effect on embryo blood vessel growth, blood vessel regeneration of adult fishes after tail-cutting and tissue regeneration of fish fries after tail-cutting. The relative fluorescence quantitative PCR method was adopted to determine the gene expression of vascular endothelial growth factor (VEGFA) and receptor VEGFR2 of fish fries after tail-cutting.
  
  
  RESULTS
  Curcumol contributed to angiogenesis of intersegmental blood vessels in zebrafishes embryos and speed up regeneration of blood vessels in adult fishes after tail-cutting. Furthermore, curcumol can increase the gene expression of VEGFA and VEGFR2 in fish fries.
  
  
  CONCLUSIONS
  Curcumol can promote angiogenesis in zebrafishes, and enhance the gene expression of VEGFA and VEGFR2 in fish fries after tail-cutting and speed up the regeneration of their tails.
authors.affiliation: School of Pharmacy, Wenzhou Medical College, Wenzhou 325035, China. lily777@163.com
authors.forename: Lili
authors.initials: L
authors.lastname: Tian
authors.forename: Jianyong
authors.initials: J
authors.lastname: Dong
authors.forename: Changjiang
authors.initials: C
authors.lastname: Huang
mesh_terms: D000818:Animals; D004625:Embryo, Nonmammalian / Q000098:blood supply / Q000187:drug effects / Q000378:metabolism; D005786:Gene Expression Regulation / Q000187:drug effects; D018919:Neovascularization, Physiologic / Q000187:drug effects*; D012717:Sesquiterpenes / Q000494:pharmacology*; D042461:Vascular Endothelial Growth Factor A / Q000235:genetics; D040301:Vascular Endothelial Growth Factor Receptor-2 / Q000235:genetics; D015027:Zebrafish / Q000196:embryology / Q000235:genetics / Q000502:physiology*
chemical_list: D012717:Sesquiterpenes; D042461:Vascular Endothelial Growth Factor A; C022801:curcumol; D040301:Vascular Endothelial Growth Factor Receptor-2