title: Use of scintigraphy to evaluate gastric accommodation and emptying: comparison with barostat.
abstract: OBJECTIVE
  Scintigraphy is a useful noninvasive technique for assessment of gastric motility, especially emptying, but there is little knowledge of use of the technique to assess gastric accommodation. Therefore, to clarify the usefulness of scintigraphy as a technique for assessing gastric accommodation, we compared scintigraphy with barostat, the gold standard modality.
  
  
  METHODS
  Twenty healthy volunteers (14 men, six women; mean age, 28.5 ± 5.4 years) were enrolled in the study. The volunteers ingested a radiolabeled ((99m) Tc) test meal and scintigraphic images were recorded. Radioactivity in the upper third and whole stomach was calculated to evaluate accommodation. In the barostat procedure, gastric accommodation was evaluated by measuring the maximum volume of the distended balloon. Thereafter, correlation between scintigraphic and barostat accommodation was investigated. Intra-and inter-observer variation of the scintigraphic test results were also assessed. Finally, the diagnostic performance of scintigraphy was evaluated by using sumatriptan as a positive control.
  
  
  RESULTS
  Measurements of accommodation by scintigraphy and barostat correlated (r = 0.524, P < 0.05). Sumatriptan significantly increased scintigraphically measured gastric accommodation (with sumatriptan, 51.5 ± 16.4%; without sumatriptan, 38.4 ± 13.8%) (P < 0.01), and had significantly (P < 0.05) delayed 50% half emptying time at 60, 90, 120, and 150 min after the start of the experiment. The data from repeated scintigraphic tests were highly reproducible (r = 0.804) with significant differences not observed among the investigators (inter-observer variation = 0.932, intra-observer variation = 0.898).
  
  
  CONCLUSIONS
  Gastric scintigraphy is a useful technique for assessing gastric accommodation and emptying.
authors.affiliation: Division of Upper Gastroenterology, Hyogo College of Medicine, Nishinomiya, Hyogo, Japan.
authors.forename: Toshihiko
authors.initials: T
authors.lastname: Tomita
authors.forename: Takuya
authors.initials: T
authors.lastname: Okugawa
authors.forename: Takahisa
authors.initials: T
authors.lastname: Yamasaki
authors.forename: Takashi
authors.initials: T
authors.lastname: Kondo
authors.forename: Fumihiko
authors.initials: F
authors.lastname: Toyoshima
authors.forename: Jun
authors.initials: J
authors.lastname: Sakurai
authors.forename: Tadayuki
authors.initials: T
authors.lastname: Oshima
authors.forename: Hirokazu
authors.initials: H
authors.lastname: Fukui
authors.forename: Takashi
authors.initials: T
authors.lastname: Daimon
authors.forename: Jiro
authors.initials: J
authors.lastname: Watari
authors.forename: Toru
authors.initials: T
authors.lastname: Kashiwagi
authors.forename: Takayuki
authors.initials: T
authors.lastname: Matsumoto
authors.forename: Hiroto
authors.initials: H
authors.lastname: Miwa
mesh_terms: D000222:Adaptation, Physiological / Q000502:physiology*; D000328:Adult; D002404:Catheterization; D005260:Female; D005502:Food; D005746:Gastric Emptying / Q000187:drug effects; D006801:Humans; D008297:Male; D015588:Observer Variation; D011868:Radioisotopes; D011877:Radionuclide Imaging; D015203:Reproducibility of Results; D058825:Serotonin 5-HT1 Receptor Agonists / Q000494:pharmacology; D018709:Statistics, Nonparametric; D013270:Stomach / Q000000981:diagnostic imaging* / Q000502:physiology*; D018170:Sumatriptan / Q000494:pharmacology; D017556:Technetium Compounds; D055815:Young Adult
chemical_list: D011868:Radioisotopes; D058825:Serotonin 5-HT1 Receptor Agonists; D017556:Technetium Compounds; D018170:Sumatriptan