title: The ortho and meta magnesiation of functionalized anilines and amino-substituted pyridines and pyrazines at room temperature.
abstract: A practical ortho,meta, (or even ortho,ortho') magnesiation of trifluoroacetamides of anilines, aminopyridines, and aminopyrazines at room temperature was performed with TMPMgCl⋅LiCl or TMP(2) Mg⋅2 LiCl. These magnesiations are compatible with several carbonyl functionalities and allow access to polysubstituted anilides in satisfactory yields.
authors.affiliation: Ludwig Maximilians-Universität München, Department Chemie & Biochemie, Butenandtstrasse 5-13, Haus F, 81377 München, Germany.
authors.forename: Gabriel
authors.initials: G
authors.lastname: Monzón
authors.forename: Ilaria
authors.initials: I
authors.lastname: Tirotta
authors.forename: Yuji
authors.initials: Y
authors.lastname: Nishii
authors.forename: Paul
authors.initials: P
authors.lastname: Knochel