title: Extensive cortical involvement in leptomeningeal carcinomatosis.
abstract: We present a 77-year-old previously well patient with facial asymmetry and progressive weakness of the lower extremities. An initial MRI revealed slight contrast enhancement of the meninges. Three consecutive cerebrospinal fluid examinations demonstrated low glucose concentration, marked elevation of total protein and moderate pleocytosis. No tumor cells, fungi, acid-fast bacilli or mycobacterial DNA were found. The patient's level of consciousness deteriorated dramatically, and follow-up MRI showed widespread extensive cortical hyperintensities. The lesions showed restricted diffusion on diffusion-weighted images as well as low values on the corresponding apparent diffusion coefficient maps, the changes consistent with diffuse cytotoxic edema. Neuropathological examination findings were of leptomeningeal carcinomatosis (LMC) with diffuse continuous infiltration of the cerebral cortex, cerebellum and spinal cord. The autopsy revealed a subcentimetre adenocarcinoma of the lung. To our knowledge, this is the first report demonstrating extensive cortical involvement in adenocarcinomatous LMC.
authors.affiliation: Department of Neurology, St. Josef Hospital, Ruhr University Bochum, Gudrunstrasse 56, Bochum 44791, Germany. ilya_ayzenberg@yahoo.com
authors.forename: I
authors.initials: I
authors.lastname: Ayzenberg
authors.forename: C
authors.initials: C
authors.lastname: Börnke
authors.forename: C
authors.initials: C
authors.lastname: Tönnes
authors.forename: W
authors.initials: W
authors.lastname: Ziebarth
authors.forename: A
authors.initials: A
authors.lastname: Lavrov
authors.forename: C
authors.initials: C
authors.lastname: Lukas
mesh_terms: D000230:Adenocarcinoma / Q000556:secondary*; D000368:Aged; D001921:Brain / Q000473:pathology*; D003937:Diagnosis, Differential; D017809:Fatal Outcome; D006801:Humans; D008175:Lung Neoplasms / Q000473:pathology; D055756:Meningeal Carcinomatosis / Q000556:secondary*; D014390:Tuberculosis, Meningeal / Q000175:diagnosis