title: Serum VEGF levels as predictive marker of bisphosphonate-related osteonecrosis of the jaw.
abstract: Recent studies have been reported that angiogenesis suppression may play a role in developing bisphosphonate-related osteonecrosis of the jaw (B-ONJ). According to these evidence we evaluated the role of VEGF as predictive marker of B-ONJ onset. Of the 81 patients, 6 developed B-ONJ following bisphosphonate treatment. These patients showed a strongest decrease in VEGF circulating levels at day 7 and at day 21 after the first administration. These data demonstrated for the first time that the anti-angiogenic properties of bisphosphonates are directly linked to B-ONJ pathogenesis and serum VEGF levels could represent an effective early predictive marker.
authors.forename: Bruno
authors.initials: B
authors.lastname: Vincenzi
authors.forename: Andrea
authors.initials: A
authors.lastname: Napolitano
authors.forename: Alice
authors.initials: A
authors.lastname: Zoccoli
authors.forename: Michele
authors.initials: M
authors.lastname: Iuliani
authors.forename: Francesco
authors.initials: F
authors.lastname: Pantano
authors.forename: Nicola
authors.initials: N
authors.lastname: Papapietro
authors.forename: Vincenzo
authors.initials: V
authors.lastname: Denaro
authors.forename: Daniele
authors.initials: D
authors.lastname: Santini
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Tonini
mesh_terms: D059266:Bisphosphonate-Associated Osteonecrosis of the Jaw / Q000097:blood* / Q000473:pathology; D006801:Humans; D012307:Risk Factors; D042461:Vascular Endothelial Growth Factor A / Q000032:analysis / Q000097:blood*
chemical_list: D042461:Vascular Endothelial Growth Factor A