title: Yeast-mediated xanthone synthesis through oxidative intramolecular cyclization.
abstract: Benzoylphloroglucinol derivatives are natural products showing diverse biological activities that could be modulated by structural modifications. For this purpose, we studied the biotransformation of guttiferone A and of maclurin using a combinatorial approach for screening active microorganism strains. We found a novel and unexpected yeast-catalyzed oxidation that has selectively given a new oxy-guttiferone A and norathyriol.
authors.affiliation: Unité Molécules de Communication et Adaptation des Micro-organismes, UMR 7245 CNRS-MNHN, 57, Rue Cuvier, CP54, 75005, Paris, France.
authors.forename: Yann
authors.initials: Y
authors.lastname: Fromentin
authors.forename: Philippe
authors.initials: P
authors.lastname: Grellier
authors.forename: Jean Duplex
authors.initials: JD
authors.lastname: Wansi
authors.forename: Marie-Christine
authors.initials: MC
authors.lastname: Lallemand
authors.forename: Didier
authors.initials: D
authors.lastname: Buisson
mesh_terms: D000818:Animals; D000962:Antimalarials / Q000737:chemistry* / Q000378:metabolism / Q000494:pharmacology; D055162:Biocatalysis; D002470:Cell Survival / Q000187:drug effects; D002522:Chlorocebus aethiops; D003500:Cyclization; D015394:Molecular Structure; D010084:Oxidation-Reduction; D010963:Plasmodium falciparum / Q000187:drug effects; D014346:Trypanosoma brucei brucei / Q000187:drug effects; D014709:Vero Cells; D044004:Xanthones / Q000737:chemistry* / Q000378:metabolism / Q000494:pharmacology; D015003:Yeasts / Q000737:chemistry* / Q000378:metabolism
chemical_list: D000962:Antimalarials; D044004:Xanthones; C009689:xanthone