title: Chromosomal radiosensitivity in Ukrainian breast cancer patients and healthy individuals.
abstract: OBJECTIVE
  Recent studies showed that increased chromosomal damage induced by ionizing radiation is observed among patients with different tumor types. The aim of the study was evaluation of chromosomal radiosensitivity in breast cancer (BC) patients (n = 37) and healthy women (n = 44).
  
  
  METHODS
  Chromosomal radiosensitivity was assessed with G0 and G2 assay. For G0 assay lymphocytes were exposed in vitro to 1,5 Gy of X-rays before culture setting. For G2 assay lymphocytes were irradiated with 0,5 Gy of X-rays after 47 h of incubation.
  
  
  RESULTS
  Significant differences in mean scores both of G0 and G2 assay between breast cancer patients and controls were observed indicating the increased chromosomal radiosensitivity of lymphocytes of cancer patients. 11% of healthy women and 38% of BC patients were determined to be radiosensitive with G2 assay.
  
  
  CONCLUSIONS
  Obtained results support the concept of association between elevated individual G2 chromosomal radiosensitivity and predisposition to BC.
authors.affiliation: RE Kavetsky Institute of Experimental Pathology, Oncology and Radiobiology, National Academy of Sciences of Ukraine, Kyiv, Ukraine. nryabchenko@ukr.net
authors.forename: N M
authors.initials: NM
authors.lastname: Ryabchenko
authors.forename: O A
authors.initials: OA
authors.lastname: Glavin
authors.forename: V V
authors.initials: VV
authors.lastname: Shtefura
authors.forename: M F
authors.initials: MF
authors.lastname: Anikushko
mesh_terms: D000328:Adult; D000368:Aged; D001943:Breast Neoplasms / Q000235:genetics* / Q000473:pathology; D016022:Case-Control Studies; D002869:Chromosome Aberrations / Q000528:radiation effects*; D003627:Data Interpretation, Statistical; D005260:Female; D016195:G2 Phase / Q000235:genetics / Q000528:radiation effects; D006801:Humans; D008214:Lymphocytes / Q000528:radiation effects*; D008875:Middle Aged; D011836:Radiation Tolerance / Q000528:radiation effects*; D016192:Resting Phase, Cell Cycle / Q000235:genetics / Q000528:radiation effects; D014455:Ukraine; D014965:X-Rays