title: [Development and neural basis of social behavior].
abstract: We have developed a multi variate analysis of social communication behavior which allows for discriminating the emotional state of an agent interacting with other agents (Bouquet method). Domestic chick or common marmoset was reared under socially isolated conditions, later tested for its development of communication behavior with peers by Bouquet, and compared with that of animals reared under grouping conditions. We found the existence of high sensitive period for social interaction, given less experience, developing less affiliated behavior. From chick model, a couple of neuronal difference was observed between two groups, amygdale core central cell size, MRI volumetric measure in mesolimbic area, and gene expression patter including brain type tryptophan hydroxylase in nucleus accumbens. The isolated chick behavior changed better to be socially affiliated by taking SSRI/SNRI or Ubiquinol (the reduced form of CoQ10) together with social interaction experience after the sensitive period. Finally, we could discriminate the behavior of Asperger syndrome children (n = 7) from that of the typically developed siblings (n = 6) during the clinical interview by applying Bouquet method.
authors.affiliation: Tokyo University of Agriculture and Technology.
authors.forename: Shun
authors.initials: S
authors.lastname: Nakamura
authors.forename: Genta
authors.initials: G
authors.lastname: Karino
authors.forename: Aya
authors.initials: A
authors.lastname: Senoo
authors.forename: Koki
authors.initials: K
authors.lastname: Mimura
authors.forename: Yuka
authors.initials: Y
authors.lastname: Shirakawa
authors.forename: Kazuyuki
authors.initials: K
authors.lastname: Yamazaki
authors.forename: Yuta
authors.initials: Y
authors.lastname: Fukushima
authors.forename: Saya
authors.initials: S
authors.lastname: Obara
authors.forename: Hitomi
authors.initials: H
authors.lastname: Sekihara
authors.forename: Shinpei
authors.initials: S
authors.lastname: Ozawa
authors.forename: Kunio
authors.initials: K
authors.lastname: Yui
authors.forename: Mamiko
authors.initials: M
authors.lastname: Koshiba
mesh_terms: D000293:Adolescent; D000818:Animals; D020817:Asperger Syndrome / Q000523:psychology; D001921:Brain / Q000502:physiology*; D002144:Callithrix; D002645:Chickens; D002648:Child; D003142:Communication; D005260:Female; D015870:Gene Expression; D006801:Humans; D008297:Male; D012919:Social Behavior