title: The influence of neural cell adhesion molecule isoform 140 on the metastasis of thyroid carcinoma.
abstract: We previously showed that the preservation of neural adhesion molecule (NCAM) in differentiated thyroid carcinoma is an important indicator for a higher risk of distant metastasis. In the present study, we further demonstrated that forced NCAM-140 isoform expression in human thyroid cancer cells could lead to aggressive growth by enhancing migration and anchorage-independent growth, and exhibiting partial features of epithelial mesenchymal transition. More extensive distant metastasis was also noted in an animal xenograft model when NCAM-expressing thyroid cancer cells were introduced into mice intravascularly. Bioinformatic analysis of NCAM-associated expression profiles predicted a highly interactive protein network, which further implies potential molecular mechanisms underlying the metastatic processes of thyroid cancer.
authors.affiliation: Department of Pathology, Taipei Veterans General Hospital, Rm. 6047, Medical Technology Building, Taipei, 11217, Taiwan. ahyang@vghtpe.gov.tw
authors.forename: An-Hang
authors.initials: AH
authors.lastname: Yang
authors.forename: Yat-Pang
authors.initials: YP
authors.lastname: Chau
authors.forename: Chen-Hsen
authors.initials: CH
authors.lastname: Lee
authors.forename: Jui-Yu
authors.initials: JY
authors.lastname: Chen
authors.forename: Jun-Yi
authors.initials: JY
authors.lastname: Chen
authors.forename: Chien-Chih
authors.initials: CC
authors.lastname: Ke
authors.forename: Ren-Shyan
authors.initials: RS
authors.lastname: Liu
mesh_terms: D000818:Animals; D015153:Blotting, Western; D004195:Disease Models, Animal; D006801:Humans; D051379:Mice; D009362:Neoplasm Metastasis; D019006:Neural Cell Adhesion Molecules / Q000235:genetics / Q000378:metabolism*; D020033:Protein Isoforms / Q000235:genetics / Q000378:metabolism*; D060888:Real-Time Polymerase Chain Reaction; D013964:Thyroid Neoplasms / Q000378:metabolism / Q000473:pathology*; D014183:Transplantation, Heterologous
chemical_list: D019006:Neural Cell Adhesion Molecules; D020033:Protein Isoforms