title: Treg cells acquire new directions, cytokines navigate.
abstract: Foxp3(+) Treg cells express transcription factors normally expressed by specific T helper cells at sites of inflammation. In this issue of Immunity, Koch et al. (2012) and Hall et al. (2012) demonstrate that IFN-γ and IL-27 distinctly induces T-bet(+) Treg cells via STAT-1 transcription factor activation.
authors.affiliation: Immunology Frontier Research Center, Osaka University, Suita, Osaka 565-0871, Japan.
authors.forename: Naganari
authors.initials: N
authors.lastname: Ohkura
authors.forename: Shimon
authors.initials: S
authors.lastname: Sakaguchi