title: Association of matrix metalloproteinase-1 polymorphisms with risk of COPD and lung cancer and survival in lung cancer.
abstract: BACKGROUND
  The primary risk factor for chronic obstructive pulmonary disease (COPD) and non-small cell lung cancer (NSCLC) is cigarette smoking but shared susceptibility factors, such as variations in the matrix metalloproteinase-1 (MMP1) gene, may also underlie both diseases.
  
  
  METHODS
  Cases with prevalent COPD (n=167), incident NSCLC (n=242), or prevalent COPD plus incident NSCLC (n=128) were compared to disease-free controls (n=338) to assess six MMP1 polymorphisms. The association between these polymorphisms and survival in NSCLC was also evaluated.
  
  
  RESULTS
  Rs11292517 among African-Americans [odds ratio (OR)=5.48, 95% confidence interval (CI)=1.17-25.72] and rs2071230 among Caucasians (OR=2.51, 95% CI=1.09-5.77) appeared to be associated with NSCLC risk in the presence of COPD. Rs470558 appeared to be associated with survival in NSCLC among African-Americans (hazard ratio=3.94; 95%CI=1.14-13.63). No associations remained after adjusting for multiple comparisons.
  
  
  CONCLUSIONS
  Polymorphisms in MMP1 were not consistently associated with prevalent COPD or incident NSCLC nor with survival in NSCLC.
authors.affiliation: Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA. lenewold@yahoo.com
authors.forename: Lindsey
authors.initials: L
authors.lastname: Enewold
authors.forename: Leah E
authors.initials: LE
authors.lastname: Mechanic
authors.forename: Elise D
authors.initials: ED
authors.lastname: Bowman
authors.forename: Elizabeth A
authors.initials: EA
authors.lastname: Platz
authors.forename: Anthony J
authors.initials: AJ
authors.lastname: Alberg
mesh_terms: D001741:Black or African American / Q000235:genetics; D000368:Aged; D002289:Carcinoma, Non-Small-Cell Lung / Q000201:enzymology / Q000208:ethnology / Q000235:genetics*; D016022:Case-Control Studies; D015331:Cohort Studies; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D008175:Lung Neoplasms / Q000201:enzymology / Q000208:ethnology / Q000235:genetics*; D008297:Male; D020781:Matrix Metalloproteinase 1 / Q000235:genetics*; D008875:Middle Aged; D011110:Polymorphism, Genetic; D029424:Pulmonary Disease, Chronic Obstructive / Q000201:enzymology / Q000208:ethnology / Q000235:genetics*; D044465:White People / Q000235:genetics
chemical_list: D020781:Matrix Metalloproteinase 1