title: Effect of dietary porphyran from the red alga, Porphyra yezoensis, on glucose metabolism in diabetic KK-Ay mice.
abstract: Porphyran (POR) from the red alga Porphyra yezoensis is a water soluble dietary fiber. In this study, we investigated the effect of dietary POR on glucose metabolism in KK-Ay mice (a model for type 2 diabetes). Mice were divided into 4 groups and fed a diet containing 5% cellulose (control), POR, POR Arg or POR K. After 3 wk of feeding, plasma insulin levels and the calculated homeostasis model assessment-insulin resistance (HOMA-IR) index were significantly lower in the POR group than in the control group. Compared with the control group, plasma adiponectin levels were significantly increased in the POR, POR Arg and POR K groups. These results suggest that dietary POR should improve glucose metabolism in diabetes via up-regulation of adiponectin levels. In addition, the amount of propionic acid in the cecum of the POR group was significantly higher than in the control group and the profile of bacterial flora was changed by dietary POR. In the cecum of the POR, POR Arg and POR K groups, Bacteroides was significantly increased and Clostridium coccoides was significantly decreased compared with in the control group. The effects of dietary POR on the hindgut environment might contribute to the improvement of glucose metabolism.
authors.affiliation: Graduate School of Agriculture, Kyoto University, Kyoto, Japan.
authors.forename: Yuki
authors.initials: Y
authors.lastname: Kitano
authors.forename: Koki
authors.initials: K
authors.lastname: Murazumi
authors.forename: Jingjing
authors.initials: J
authors.lastname: Duan
authors.forename: Kosuke
authors.initials: K
authors.lastname: Kurose
authors.forename: Shunichi
authors.initials: S
authors.lastname: Kobayashi
authors.forename: Tatsuya
authors.initials: T
authors.lastname: Sugawara
authors.forename: Takashi
authors.initials: T
authors.lastname: Hirata
mesh_terms: D052242:Adiponectin / Q000097:blood; D000818:Animals; D002432:Cecum / Q000378:metabolism / Q000382:microbiology; D002784:Cholesterol / Q000097:blood; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000188:drug therapy* / Q000378:metabolism*; D004043:Dietary Fiber / Q000494:pharmacology*; D004195:Disease Models, Animal; D005230:Fatty Acids, Nonesterified / Q000097:blood; D005947:Glucose / Q000378:metabolism*; D007328:Insulin / Q000097:blood; D007333:Insulin Resistance; D008297:Male; D051379:Mice; D044664:Porphyra / Q000737:chemistry*; D012329:RNA, Bacterial / Q000737:chemistry / Q000235:genetics; D060888:Real-Time Polymerase Chain Reaction; D012685:Sepharose / Q000031:analogs & derivatives* / Q000494:pharmacology; D014280:Triglycerides / Q000097:blood
chemical_list: D052242:Adiponectin; D004043:Dietary Fiber; D005230:Fatty Acids, Nonesterified; D007328:Insulin; D012329:RNA, Bacterial; D014280:Triglycerides; C038549:porphyran; D012685:Sepharose; D002784:Cholesterol; D005947:Glucose