title: How a common variant in the growth factor receptor gene, NTRK1, affects white matter.
abstract: Growth factors and their receptors are important for cellular migration as well as axonal guidance and myelination in the brain. They also play a key role in programmed cell death, and are implicated in a number of mental illnesses. Recently, we reported that healthy young adults who carry the T allele variant in the growth factor gene, NTRK1 (at location rs6336), had lower white matter integrity than non-carriers on diffusion images of the brain. Diffusion tensor imaging (DTI) revealed how this single nucleotide polymorphism affects white matter microstructure in human populations; DTI is also used to identify characteristic features of brain connectivity in typically developing children and in patients. Newly discovered links between neuroimaging measures and growth factors whose molecular neuroscience is well known offer an important step in understanding mechanisms that contribute to brain connectivity. Altered fiber connectivity may mediate the relationship between some genetic risk factors and a variety of mental illnesses.
authors.affiliation: Imaging Genetics Center at the Laboratory of Neuro Imaging; Department of Neurology; UCLA School of Medicine; Los Angeles, CA USA.
authors.forename: Meredith N
authors.initials: MN
authors.lastname: Braskie
authors.affiliation: Imaging Genetics Center at the Laboratory of Neuro Imaging; Department of Neurology; UCLA School of Medicine; Los Angeles, CA USA.
authors.forename: Neda
authors.initials: N
authors.lastname: Jahanshad
authors.affiliation: Imaging Genetics Center at the Laboratory of Neuro Imaging; Department of Neurology; UCLA School of Medicine; Los Angeles, CA USA.
authors.forename: Arthur W
authors.initials: AW
authors.lastname: Toga
authors.affiliation: Centre for Advanced Imaging; University of Queensland; Brisbane, QLD Australia.
authors.forename: Katie L
authors.initials: KL
authors.lastname: McMahon
authors.affiliation: School of Psychology; University of Queensland; Brisbane, QLD Australia.
authors.forename: Greig I
authors.initials: GI
authors.lastname: de Zubicaray
authors.affiliation: Queensland Institute of Medical Research; Brisbane, QLD Australia.
authors.forename: Nicholas G
authors.initials: NG
authors.lastname: Martin
authors.affiliation: Queensland Institute of Medical Research; Brisbane, QLD Australia.
authors.forename: Margaret J
authors.initials: MJ
authors.lastname: Wright
authors.affiliation: Imaging Genetics Center at the Laboratory of Neuro Imaging; Department of Neurology; UCLA School of Medicine; Los Angeles, CA USA.
authors.forename: Paul M
authors.initials: PM
authors.lastname: Thompson
mesh_terms: D014644:Genetic Variation / Q000235:genetics*; D006801:Humans; D056784:Leukoencephalopathies / Q000235:genetics* / Q000473:pathology; D020917:Receptor, trkA / Q000235:genetics*; D066127:White Matter / Q000378:metabolism / Q000473:pathology*
chemical_list: D020917:Receptor, trkA