title: Central nervous system marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue type involving the brain and spinal cord parenchyma.
abstract: We present a case of a 53-year-old HIV negative man with a 2-month history of progressive recent memory disturbance, gait disturbance and urinary incontinence. On MRI, an infiltrative tumor in the brain and spinal cord was noted. Subsequent positron emission tomography studies along with bone marrow biopsy and serum protein electrophoresis showed no evidence of systemic disease. Open brain biopsy results revealed a small lymphocytic infiltrate with scattered plasma cells in a predominantly perivascular growth pattern. The morphology was consistent with involvement by a low-grade B-cell lymphoma. Immunohistochemical findings showed CD20+, CD10-, CD5-, TdT-, EBV-encoded RNA in situ- and IgM-. The above findings were consistent with involvement by a non-dural extranodal marginal zone B-cell lymphoma (MZBCL) primary to the brain and spinal cord. This is a case report of a CNS MZBCL of mucosa-associated lymphoid tissue type involving the brain and spinal cord parenchyma.
authors.affiliation: Department of Neurosurgery, Fukuoka University, Fukuoka, Japan. tueba@fukuoka-u.ac.jp
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Ueba
authors.forename: Masakazu
authors.initials: M
authors.lastname: Okawa
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Abe
authors.forename: Tooru
authors.initials: T
authors.lastname: Inoue
authors.forename: Koichi
authors.initials: K
authors.lastname: Takano
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Hayashi
authors.forename: Kazuki
authors.initials: K
authors.lastname: Nabeshima
authors.forename: Koichi
authors.initials: K
authors.lastname: Oshima
mesh_terms: D001706:Biopsy; D001921:Brain / Q000473:pathology* / Q000601:surgery; D001932:Brain Neoplasms / Q000473:pathology* / Q000601:surgery; D006801:Humans; D007150:Immunohistochemistry; D018442:Lymphoma, B-Cell, Marginal Zone / Q000473:pathology* / Q000601:surgery; D008297:Male; D008875:Middle Aged; D049268:Positron-Emission Tomography; D013116:Spinal Cord / Q000473:pathology* / Q000601:surgery; D013120:Spinal Cord Neoplasms / Q000473:pathology* / Q000601:surgery