title: Increased MPV is not a significant predictor for preeclampsia during pregnancy.
abstract: BACKGROUND
  Preeclampsia, defined as the presence of hypertension and proteinuria, is usually related with maternal and neonatal adverse effects. However, the exact predictor of preeclampsia is still lacking. Even though there are some conflicting data, mean platelet value or MPV, that is, platelet ratio with or without Doppler velocimetry was determined as highly sensitive markers for preeclampsia. We aimed to investigate the utility of MPV in prediction of preeclampsia.
  
  
  METHODS
  Seventy-four preeclamptic pregnant women (21 in mild, 53 in severe preeclampsia groups) were included in the study. To assess the difference of MPV between preeclamptic, normal pregnant, and healthy control rather than mild and severe preeclamptic pregnant women, we included in the analysis 31 healthy pregnant women and 35 healthy nonpregnant women.
  
  
  RESULTS
  Mean age of the preeclamptic patients was 25.3 (17-38) years. Platelet levels were higher in mild preeclampsia (group 1) than severe preeclampsia (group 2), whereas alanine aminotransferase (AST), hemoglobin, and hematocrit level was higher in group 2. MPV levels were found to be similar in groups 1 and 2, MPV level increased from healthy control to preeclamptic women (P = 0.003). MPV:platelet ratio was similar according to the severity of preeclampsia (P = 0.123). Doppler velocimetry did not add an additional benefit to predict preeclampsia or its severity.
  
  
  CONCLUSIONS
  Our results showed that MPV level was higher in the pregnant than the control group. However, MPV did not differ both between mild and severe preeclampsia, and preeclampsia and non-preeclamptic pregnant women.
authors.affiliation: Zekai Tahir Burak Women Health Research and Education Hospital, Ankara, Turkey. drsibela@yahoo.com.tr
authors.forename: Sibel
authors.initials: S
authors.lastname: Altınbas
authors.forename: Cihan
authors.initials: C
authors.lastname: Toğrul
authors.forename: Anıl
authors.initials: A
authors.lastname: Orhan
authors.forename: Munihe
authors.initials: M
authors.lastname: Yücel
authors.forename: Nuri
authors.initials: N
authors.lastname: Danısman
mesh_terms: D000293:Adolescent; D000328:Adult; D001792:Blood Platelets / Q000166:cytology*; D005260:Female; D006801:Humans; D017078:Laser-Doppler Flowmetry; D011225:Pre-Eclampsia / Q000097:blood*; D011237:Predictive Value of Tests; D011247:Pregnancy; D018709:Statistics, Nonparametric