title: Catalysis-based enantioselective total synthesis of myxothiazole Z, (14S)-melithiazole G and (14S)-cystothiazole F.
abstract: A common strategy for the stereoselective and protecting group-free total synthesis of the myxobacterial antibiotics myxothiazole Z, (14S)-melithiazole G and (14S)-cystothiazole F is described featuring an asymmetric organocatalytic transfer hydrogenation, a palladium-catalyzed Stille coupling and a cross-metathesis as the key steps.
authors.affiliation: Laboratoire de Chimie Organique, ESPCI ParisTech, CNRS, 10 rue Vauquelin, 75231 Paris Cedex 05, France.
authors.forename: Aude
authors.initials: A
authors.lastname: Colon
authors.forename: Thomas J
authors.initials: TJ
authors.lastname: Hoffman
authors.forename: Julian
authors.initials: J
authors.lastname: Gebauer
authors.forename: Jyotirmayee
authors.initials: J
authors.lastname: Dash
authors.forename: James H
authors.initials: JH
authors.lastname: Rigby
authors.forename: Stellios
authors.initials: S
authors.lastname: Arseniyadis
authors.forename: Janine
authors.initials: J
authors.lastname: Cossy
mesh_terms: D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000737:chemistry; D002384:Catalysis; D006865:Hydrogenation; D010165:Palladium / Q000737:chemistry; D013237:Stereoisomerism; D013844:Thiazoles / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D000900:Anti-Bacterial Agents; D013844:Thiazoles; C578293:cystothiazole F; C578292:melithiazole G; C578291:myxothiazole Z; D010165:Palladium