title: HyperCKemia related to the initial and recurrent attacks of neuromyelitis optica.
abstract: We herein report the case of a 60-year-old man showing overexpression of creatine kinase (hyperCKemia) related to initial and recurrent attacks of neuromyelitis optica (NMO). He showed reduced vision, ataxia and dysesthesia, but no symptoms originating in the muscles. Magnetic resonance imaging (MRI) revealed lesions in the optic nerve, medulla oblongata, and spinal cord similar to typical NMO patients. However, femoral MRI and whole positron emission tomography (PET) demonstrated no abnormal findings during an episode of hyperCKemia. This case suggests that hyperCKemia is partly involved in the pathogenesis of NMO in both the central nervous system and myofiber surface, which is usually difficult to detect by clinical imaging modalities alone.
authors.affiliation: Department of Neurology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Japan.
authors.forename: Shoko
authors.initials: S
authors.lastname: Deguchi
authors.forename: Kentaro
authors.initials: K
authors.lastname: Deguchi
authors.forename: Kota
authors.initials: K
authors.lastname: Sato
authors.forename: Taijun
authors.initials: T
authors.lastname: Yunoki
authors.forename: Yoshio
authors.initials: Y
authors.lastname: Omote
authors.forename: Nobutoshi
authors.initials: N
authors.lastname: Morimoto
authors.forename: Tomoko
authors.initials: T
authors.lastname: Kurata
authors.forename: Masami
authors.initials: M
authors.lastname: Ikeda
authors.forename: Toshiyuki
authors.initials: T
authors.lastname: Takahashi
authors.forename: Masashi
authors.initials: M
authors.lastname: Aoki
authors.forename: Koji
authors.initials: K
authors.lastname: Abe
mesh_terms: D003402:Creatine Kinase / Q000378:metabolism*; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008526:Medulla Oblongata / Q000473:pathology; D008875:Middle Aged; D009471:Neuromyelitis Optica / Q000201:enzymology* / Q000209:etiology* / Q000473:pathology; D009900:Optic Nerve / Q000473:pathology; D012008:Recurrence; D013116:Spinal Cord / Q000473:pathology
chemical_list: D003402:Creatine Kinase