title: Eggshell-inspired biomineralization generates vaccines that do not require refrigeration.
abstract: We're not gonna bake it: In situ biomineralization creates an egg-like shell on vaccine particles to improve their thermostability. Different from the bare vaccine (squares), the biomineralized vaccine (red circles) can be stored at ambient temperature without refrigeration for up to a week and retain biological activity both in vitro (see graph), as well as in a mouse model.
authors.affiliation: Center for Biomaterials and Biopathways, Zhejiang University, Hangzhou, Zhejiang 310027, China.
authors.forename: Guangchuan
authors.initials: G
authors.lastname: Wang
authors.forename: Xiaofeng
authors.initials: X
authors.lastname: Li
authors.forename: Lijuan
authors.initials: L
authors.lastname: Mo
authors.forename: Zhiyong
authors.initials: Z
authors.lastname: Song
authors.forename: Wei
authors.initials: W
authors.lastname: Chen
authors.forename: Yongqiang
authors.initials: Y
authors.lastname: Deng
authors.forename: Hui
authors.initials: H
authors.lastname: Zhao
authors.forename: Ede
authors.initials: E
authors.lastname: Qin
authors.forename: Chengfeng
authors.initials: C
authors.lastname: Qin
authors.forename: Ruikang
authors.initials: R
authors.lastname: Tang
mesh_terms: D000818:Animals; D004355:Drug Stability; D004356:Drug Storage / Q000592:standards; D004528:Egg Shell / Q000737:chemistry* / Q000276:immunology*; D051379:Mice; D008807:Mice, Inbred BALB C; D012034:Refrigeration; D014612:Vaccines / Q000737:chemistry*
chemical_list: D014612:Vaccines