title: Introduction of a high-throughput double-stent animal model for the evaluation of biodegradable vascular stents.
abstract: Current stent system efficacy for the treatment of coronary artery disease is hampered by in-stent restenosis (ISR) rates of up to 20% in certain high-risk settings and by the risk of stent thrombosis, which is characterized by a high mortality rate. In theory, biodegradable vascular devices exhibit crucial advantages. Most absorbable implant materials are based on poly-L-lactic acid (PLLA) owing to its mechanical properties; however, PLLA might induce an inflammatory reaction in the vessel wall. Evaluation of biodegradable implant efficacy includes a long-term examination of tissue response; therefore, a simple in vivo tool for thorough biocompatibility and biodegradation evaluation would facilitate future stent system development. Rats have been used for the study of in vivo degradation processes, and stent implantation into the abdominal aorta of rats is a proven model for stent evaluation. Here, we report the transformation of the porcine double-stent animal model into the high-throughput rat abdominal aorta model. As genetic manipulation of rats was introduced recently, this novel method presents a powerful tool for future in vivo biodegradable candidate stent biocompatibility and biodegradation characterization in a reliable simple model of coronary ISR.
authors.affiliation: Department of Cardiology, RWTH Aachen University, Aachen, Germany.
authors.forename: Mauricio
authors.initials: M
authors.lastname: Borinski
authors.forename: Christian
authors.initials: C
authors.lastname: Flege
authors.forename: Fabian
authors.initials: F
authors.lastname: Schreiber
authors.forename: Nicole
authors.initials: N
authors.lastname: Krott
authors.forename: Thomas
authors.initials: T
authors.lastname: Gries
authors.forename: Elisa
authors.initials: E
authors.lastname: Liehn
authors.forename: Rüdiger
authors.initials: R
authors.lastname: Blindt
authors.forename: Nikolaus
authors.initials: N
authors.lastname: Marx
authors.forename: Felix
authors.initials: F
authors.lastname: Vogt
mesh_terms: D020341:Absorbable Implants; D000818:Animals; D001012:Aorta, Abdominal / Q000601:surgery; D001807:Blood Vessel Prosthesis; D019917:Blood Vessel Prosthesis Implantation / Q000379:methods; D004195:Disease Models, Animal; D006801:Humans; D019344:Lactic Acid; D008422:Materials Testing / Q000379:methods*; D011091:Polyesters; D011108:Polymers; D051381:Rats; D017207:Rats, Sprague-Dawley; D015607:Stents
chemical_list: D011091:Polyesters; D011108:Polymers; D019344:Lactic Acid; C033616:poly(lactide)