title: Breast cancer and metastasis: on the way toward individualized therapy.
abstract: Breast cancer (BC) remains the most common cancer type diagnosed in women. Although targeted therapies have improved patient survival for advanced BC, these tumors frequently relapse due to drug resistance mechanisms. A systems biology approach integrates DNA, RNA and protein alterations generated from multidimensional platforms to better understand the mechanisms that regulate the metastatic process. Downstream functional analyses in pre-clinical studies might integrate the role of these aberrations into the cell, leading to discovery of new therapeutic targets. In the present report, we review relevant findings associated with genomic, transcriptomic and proteomic analyses and the contribution of the systems biology concept to the interpretation of these data in the metastatic context. Also, we highlight the importance of re-designing clinical trials towards metastasis prevention for improvement of personalized care.
authors.affiliation: Department of Breast Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030-4009, U.S.A.
authors.forename: Adriana Priscila
authors.initials: AP
authors.lastname: Trapé
authors.forename: Ana Maria
authors.initials: AM
authors.lastname: Gonzalez-Angulo
mesh_terms: D014408:Biomarkers, Tumor / Q000235:genetics / Q000378:metabolism; D001943:Breast Neoplasms / Q000188:drug therapy* / Q000235:genetics / Q000378:metabolism / Q000473:pathology; D002986:Clinical Trials as Topic; D056915:DNA Copy Number Variations; D019175:DNA Methylation; D004273:DNA, Neoplasm / Q000235:genetics; D005260:Female; D052138:Genes, Neoplasm; D006801:Humans; D009362:Neoplasm Metastasis / Q000188:drug therapy* / Q000235:genetics / Q000473:pathology; D057285:Precision Medicine / Q000379:methods*; D020543:Proteome / Q000032:analysis; D049490:Systems Biology / Q000379:methods; D059467:Transcriptome; D059016:Tumor Microenvironment
chemical_list: D014408:Biomarkers, Tumor; D004273:DNA, Neoplasm; D020543:Proteome