title: [Expressions of peroxiredoxin 1, peroxiredoxin 6 and GFAP in human brain astrocytoma and their clinical significance].
abstract: OBJECTIVE
  To characterize the expressions of peroxiredoxin 1 (Prx1), peroxiredoxin 6 (Prx6) and glial fibrillary acidic protein (GFAP) in human brain astrocytoma and explore their clinical significance.
  
  
  METHODS
  The protein and mRNA expression levels of Prx1, Prx6 and GFAP in human brain astrocytoma and normal brain tissue specimens were determined by Western blotting, RT-PCR and immunohistochemistry.
  
  
  RESULTS
  The protein and mRNA expressions of Prx1 and Prx6 increased significantly in the order of normal brain tissue, grade II astrocytoma, grade III astrocytoma and grade IV astrocytoma (P<0.05). The protein and mRNA expressions of GFAP decreased significantly in  grade III and IV astrocytoma compared with those in grade II astrocytoma and normal brain tissues (P<0.05).
  
  
  CONCLUSIONS
  Prx1 and Prx6 may play important roles in the invasion and malignant development of human brain astrocytoma, and may serve as biomarkers for evaluating the invasiveness, malignancy and prognosis of the tumor as well as potential molecular targets in astrocytoma therapy.
authors.affiliation: First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China. zhoujinqiao@sina.com
authors.forename: Jinqiao
authors.initials: J
authors.lastname: Zhou
authors.forename: Qiuhong
authors.initials: Q
authors.lastname: Liu
authors.forename: Jingtao
authors.initials: J
authors.lastname: Wang
authors.forename: Xinbin
authors.initials: X
authors.lastname: Guo
authors.forename: Laijun
authors.initials: L
authors.lastname: Song
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001254:Astrocytoma / Q000378:metabolism* / Q000473:pathology; D001932:Brain Neoplasms / Q000378:metabolism* / Q000473:pathology; D002648:Child; D002675:Child, Preschool; D005260:Female; D005904:Glial Fibrillary Acidic Protein / Q000378:metabolism*; D006801:Humans; D008297:Male; D008875:Middle Aged; D054465:Peroxiredoxin VI / Q000378:metabolism*; D054464:Peroxiredoxins / Q000378:metabolism*; D055815:Young Adult
chemical_list: D005904:Glial Fibrillary Acidic Protein; C515940:PRDX1 protein, human; C515977:PRDX6 protein, human; D054465:Peroxiredoxin VI; D054464:Peroxiredoxins