title: [Development of a perforated peptic ulcer in a child during high dose prednisolone treatment].
abstract: Since perforated peptic ulcer is uncommon in children proton pump inhibitor prophylaxis is not routinely recommended when children are treated with high dose steroids. We describe a case of perforated ulcer in a six-year-old patient with nephrotic syndrome treated with high dose prednisolone. Initially, ulcer was not suspected due to uncharacteristic symptoms. The child developed peritoneal signs and surgery revealed a perforated peptic ulcer in the stomach. We recommend treatment with proton pump inhibitors if children, who are treated with high dose steroids develop abdominal symptoms, which can be caused by an ulcus.
authors.affiliation: Børneafdelingen, Hvidovre Hospital, Kettegård Allé 30, Hvidovre.
authors.forename: Kirstine
authors.initials: K
authors.lastname: Moll Harboe
authors.forename: Helle
authors.initials: H
authors.lastname: Midtgaard
authors.forename: Vibeke
authors.initials: V
authors.lastname: Wewer
authors.forename: Dina
authors.initials: D
authors.lastname: Cortes
mesh_terms: D002648:Child; D005938:Glucocorticoids / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D006801:Humans; D008297:Male; D009404:Nephrotic Syndrome / Q000188:drug therapy; D010439:Peptic Ulcer Perforation / Q000139:chemically induced* / Q000150:complications / Q000000981:diagnostic imaging / Q000628:therapy; D011239:Prednisolone / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D011859:Radiography; D013276:Stomach Ulcer / Q000139:chemically induced* / Q000150:complications / Q000000981:diagnostic imaging / Q000628:therapy
chemical_list: D005938:Glucocorticoids; D011239:Prednisolone