title: The influence of low flow anaesthesia on renal function in cancer patients previously treated with nephrotoxic chemotherapeutic agents.
abstract: BACKGROUND
  The aim of this study was to assess renal morbidity, associated with the use of low flow anaesthesia (LFA), in cancer patients previously treated with nephrotoxic chemotherapeutic agents.
  
  
  METHODS
  Seventy-five patients, aged 30-70 years, scheduled for elective surgery, were randomly allocated to three groups: Group A included those patients who had received nephrotoxic chemotherapeutic agents (cisplatin, carboplatin, methotrexate or cyclophosphamide) within 90 days before surgery, and who were anaesthetised with low flow (0.8(-1) L min(-1)) air-oxygen-sevoflurane (1-3 MAC) anaesthesia; Group B included similar patients who received high flow (6 L min-1) anaesthesia. Non-cancer patients receiving low flow anaesthesia served as controls. Blood was sampled for serum creatinine, BUN, cistatin C, and electrolytes (Na(+), K(+), Cl(-), Ca(2+), P(3+), Mg(2+)) before anaesthesia, and one, three and five days after.
  
  
  RESULTS
  There were no statistically significant differences between the groups.
  
  
  CONCLUSIONS
  The use of low flow sevoflurane anaesthesia is not associated with an increased risk of nephrotoxicity in those previously exposed to nephrotoxic chemotherapeutic agents.
authors.affiliation: Department of Anaesthesiology and Intensive Therapy, Medical University of Gdańsk. mwuj@gumed.edu.pl
authors.forename: Maria
authors.initials: M
authors.lastname: Wujtewicz
authors.forename: Wioletta
authors.initials: W
authors.lastname: Sawicka
authors.forename: Wojciech
authors.initials: W
authors.lastname: Wenski
authors.forename: Andrzej
authors.initials: A
authors.lastname: Marciniak
authors.forename: Magdalena A
authors.initials: MA
authors.lastname: Wujtewicz
authors.forename: Piotr
authors.initials: P
authors.lastname: Stepnowski
authors.forename: Paweł
authors.initials: P
authors.lastname: Twardowski
authors.forename: Anna
authors.initials: A
authors.lastname: Dylczyk-Sommer
authors.forename: Radosław
authors.initials: R
authors.lastname: Owczuk
mesh_terms: D000328:Adult; D000368:Aged; D000769:Anesthesia, Inhalation / Q000379:methods*; D000970:Antineoplastic Agents / Q000009:adverse effects*; D003404:Creatinine / Q000097:blood; D004573:Electrolytes / Q000097:blood; D005260:Female; D006801:Humans; D007668:Kidney / Q000187:drug effects / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000188:drug therapy / Q000503:physiopathology*
chemical_list: D000970:Antineoplastic Agents; D004573:Electrolytes; D003404:Creatinine