title: Adenocarcinoma of the lung with miliary brain and pulmonary metastases with echinoderm microtubule-associated protein like 4-anaplastic lymphoma kinase translocation treated with crizotinib: a case report.
abstract: Few descriptions of miliary brain metastases have been reported. We report the case of an adenocarcinoma of the lung associated with metachronous miliary brain and lung metastases with an echinoderm microtubule-associated protein like 4-anaplastic lymphoma kinase (EML4-ALK) gene translocation. The patient was treated with crizotinib and showed a twelve-month progression-free survival. Clinicians should be attentive of the evolution of brain metastases with patients presenting EML4-ALK translocation.
authors.affiliation: Medical Oncology Department, Centre Antoine Lacassagne, 33 Avenue de Valombrose, 06189 Nice Cedex 2, France. alexander.falk.fr@gmail.com
authors.forename: Alexander T
authors.initials: AT
authors.lastname: Falk
authors.forename: Michel
authors.initials: M
authors.lastname: Poudenx
authors.forename: Josiane
authors.initials: J
authors.lastname: Otto
authors.forename: Hannah
authors.initials: H
authors.lastname: Ghalloussi
authors.forename: Jérôme
authors.initials: J
authors.lastname: Barrière
mesh_terms: D000230:Adenocarcinoma / Q000175:diagnosis* / Q000188:drug therapy / Q000235:genetics / Q000556:secondary; D000328:Adult; D061067:Antibodies, Monoclonal, Humanized / Q000008:administration & dosage; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D000068258:Bevacizumab; D001932:Brain Neoplasms / Q000175:diagnosis* / Q000188:drug therapy / Q000235:genetics / Q000556:secondary; D002945:Cisplatin / Q000008:administration & dosage; D000077547:Crizotinib; D004252:DNA Mutational Analysis; D003841:Deoxycytidine / Q000008:administration & dosage / Q000031:analogs & derivatives; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000175:diagnosis* / Q000188:drug therapy / Q000235:genetics / Q000473:pathology; D025202:Molecular Diagnostic Techniques; D015514:Oncogene Proteins, Fusion / Q000378:metabolism*; D011720:Pyrazoles / Q000008:administration & dosage; D011725:Pyridines / Q000008:administration & dosage; D014178:Translocation, Genetic; D000093542:Gemcitabine
chemical_list: D061067:Antibodies, Monoclonal, Humanized; C522504:EML4-ALK fusion protein, human; D015514:Oncogene Proteins, Fusion; D011720:Pyrazoles; D011725:Pyridines; D003841:Deoxycytidine; D000068258:Bevacizumab; D000077547:Crizotinib; D002945:Cisplatin; D000093542:Gemcitabine