title: Involvement of the anterior cingulate cortex in formation, consolidation, and reconsolidation of recent and remote contextual fear memory.
abstract: It has been suggested that memories become more stable and less susceptible to the disruption of reconsolidation over weeks after learning. Here, we test this by targeting the anterior cingulate cortex (ACC) and test its involvement in the formation, consolidation, and reconsolidation of recent and remote contextual fear memory. We found that inhibiting NMDAR-NR2B activity disrupts memory formation, and that infusion of the protein-synthesis inhibitor anisomycin impairs memory consolidation and reconsolidation of recent and remote memory. Our findings demonstrate for the first time that the ACC plays an important role in reconsolidation of contextual fear memory at recent and remote time points.
authors.affiliation: Department of Psychology, McGill University, Montreal, Quebec, Canada.
authors.forename: Einar Ö
authors.initials: EÖ
authors.lastname: Einarsson
authors.forename: Karim
authors.initials: K
authors.lastname: Nader
mesh_terms: D000161:Acoustic Stimulation / Q000009:adverse effects; D000704:Analysis of Variance; D000818:Animals; D000841:Anisomycin / Q000494:pharmacology; D003214:Conditioning, Classical / Q000187:drug effects / Q000502:physiology*; D018691:Excitatory Amino Acid Antagonists / Q000494:pharmacology; D005239:Fear; D006179:Gyrus Cinguli / Q000187:drug effects / Q000502:physiology*; D006624:Hippocampus / Q000187:drug effects / Q000502:physiology; D008297:Male; D057567:Memory, Long-Term / Q000187:drug effects / Q000502:physiology*; D008570:Memory, Short-Term / Q000187:drug effects / Q000502:physiology*; D010636:Phenols / Q000494:pharmacology; D010880:Piperidines / Q000494:pharmacology; D011500:Protein Synthesis Inhibitors / Q000494:pharmacology; D051381:Rats; D017207:Rats, Sprague-Dawley; D013997:Time Factors
chemical_list: D018691:Excitatory Amino Acid Antagonists; D010636:Phenols; D010880:Piperidines; D011500:Protein Synthesis Inhibitors; C109643:Ro 25-6981; D000841:Anisomycin