title: Association of syndecan-1 with angiogenesis-related markers, extracellular matrix components, and clinicopathological features in colorectal carcinoma.
abstract: Syndecan-1 is a transmembrane heparansulfate proteoglycan, which regulates cell proliferation, migration, angiogenesis, cell-to-cell and cell-to-extracellular matrix adhesion and may influence malignant cell behavior. We investigated the alterations of syndecan-1 expression in colorectal cancer and analyzed the relationship between clinicopathological parameters, proliferation indices, angiogenic markers, and extracellular matrix components. Syndecan-1 protein expression observed in the tumorous epithelium was high in 52/97 (53.6%) of the studied cases, moderate in 20/97 (20.6%), and weak in 5/97 (5.22%) of the cases, and there was strong stromal expression in 34.02% of the tumors. Syndecan-1 expression was statistically correlated to VEGF expression in tumor (p=0.001) and vessels (p=0.007). In addition, there was a borderline correlation between syndecan-1 expression and tenascin (p=0.053). Patients with weak staining reaction had a more unfavorable prognosis (p=0.032) in univariate analysis. These results indicate the implication of syndecan-1 in the remodeling and angiogenesis of colorectal cancer tissue, through interaction with other extracellular matrix components and VEGF, probably influencing the tumor progression and aggressiveness.
authors.affiliation: Department of Forensic Pathology, Medical School, University of Ioannina, Ioannina, Greece. amitselo@cc.uoi.gr
authors.forename: Antigony
authors.initials: A
authors.lastname: Mitselou
authors.forename: Urania
authors.initials: U
authors.lastname: Skoufi
authors.forename: Konstantinos E
authors.initials: KE
authors.lastname: Tsimogiannis
authors.forename: Evagelos
authors.initials: E
authors.lastname: Briasoulis
authors.forename: Theodoros
authors.initials: T
authors.lastname: Vougiouklakis
authors.forename: Dimitris
authors.initials: D
authors.lastname: Arvanitis
authors.forename: Elli
authors.initials: E
authors.lastname: Ioachim
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D024141:Collagen Type IV / Q000096:biosynthesis; D015179:Colorectal Neoplasms / Q000098:blood supply / Q000378:metabolism* / Q000473:pathology; D005109:Extracellular Matrix / Q000378:metabolism* / Q000473:pathology; D005260:Female; D005353:Fibronectins / Q000096:biosynthesis; D006801:Humans; D007150:Immunohistochemistry; D007797:Laminin / Q000096:biosynthesis; D008297:Male; D008875:Middle Aged; D009389:Neovascularization, Pathologic / Q000378:metabolism / Q000473:pathology; D053668:Syndecan-1 / Q000096:biosynthesis*; D019063:Tenascin / Q000096:biosynthesis
chemical_list: D024141:Collagen Type IV; D005353:Fibronectins; D007797:Laminin; C508241:SDC1 protein, human; D053668:Syndecan-1; D019063:Tenascin