title: The effects of VARC-defined acute kidney injury after transcatheter aortic valve implantation (TAVI) using the Edwards bioprosthesis.
abstract: OBJECTIVE
  The aim of this study was to identify the incidence and risk factors for acute kidney injury (AKI) after TAVI, a potentially serious complication of transcatheter aortic valve implantation (TAVI) that has been redefined by the Valve Academic Research Consortium (VARC).
  
  
  RESULTS
  We performed a retrospective analysis of 248 patients undergoing TAVI. AKI was defined as a VARC-modified Risk, Injury, Failure, Loss, and End-stage (RIFLE) kidney disease score ≥ 2. Eighty-nine patients suffered AKI (35.9%) and demonstrated increased mortality at 30 days (13.5% vs. 3.8%) and one year (31.5% vs. 15.0%) (p<0.001). Multivariate regression analysis identified diabetes mellitus (p<0.001), peripheral vascular disease (p=0.007), chronic kidney disease stage (p=0.010) as independently associated risk factors for AKI.
  
  
  CONCLUSIONS
  More than one third of patients sustain AKI after TAVI using the Edwards bioprosthesis, as defined by the VARC-modified RIFLE score. AKI increased the mortality at both 30 days and at one year. A history of diabetes mellitus, peripheral vascular disease and higher chronic kidney disease stage had the strongest independent associations with post-TAVI AKI.
authors.affiliation: King's College London, BHF Centre of Research Excellence, Cardiovascular Division, The Rayne Institute, London, United Kingdom. dr.zeeshan.khawaja@gmail.com
authors.forename: Muhammed Zeeshan
authors.initials: MZ
authors.lastname: Khawaja
authors.forename: Martyn
authors.initials: M
authors.lastname: Thomas
authors.forename: Abhishek
authors.initials: A
authors.lastname: Joshi
authors.forename: Kaleab N
authors.initials: KN
authors.lastname: Asrress
authors.forename: Karen
authors.initials: K
authors.lastname: Wilson
authors.forename: Kirsty
authors.initials: K
authors.lastname: Bolter
authors.forename: Christopher P
authors.initials: CP
authors.lastname: Young
authors.forename: Jane
authors.initials: J
authors.lastname: Hancock
authors.forename: Vinayak
authors.initials: V
authors.lastname: Bapat
authors.forename: Simon
authors.initials: S
authors.lastname: Redwood
mesh_terms: D058186:Acute Kidney Injury / Q000453:epidemiology* / Q000209:etiology / Q000401:mortality; D000368:Aged; D000369:Aged, 80 and over; D001021:Aortic Valve / Q000601:surgery*; D001705:Bioprosthesis; D006328:Cardiac Catheterization; D005260:Female; D019918:Heart Valve Prosthesis Implantation / Q000009:adverse effects*; D006801:Humans; D016015:Logistic Models; D008297:Male; D012189:Retrospective Studies; D012307:Risk Factors