title: Triphenyl phosphite, a new allergen in polyvinylchloride gloves.
abstract: BACKGROUND
  Contact allergy to polyvinylchloride (PVC) gloves has been reported relatively seldom. In spring 2011, 5 of our patients had patch test reactions to PVC gloves. We obtained a collection of PVC raw materials from industrial producers and suppliers of chemical compounds to be patch tested on patients with suspected PVC glove contact allergy.
  
  
  OBJECTIVE
  To report the first results of these new test substances.
  
  
  METHODS
  The patients were patch tested with the newly obtained test substances, plastics and glues series, and isocyanates and isocyanate prepolymers. We analysed nine PVC glove samples for triphenyl phosphate and its derivatives.
  
  
  RESULTS
  Two patients reacted to a technical PVC antioxidant and one of its components, triphenyl phosphite (TPP). Contact allergy to TPP was very strong in 1 patient, and was the main cause of her hand dermatitis, whereas the other patient also had other contact allergies explaining her symptoms. Three patients reacted to their PVC gloves, but the specific allergen was not identified. Six PVC glove samples contained TPP at concentrations of 0.004-0.099%. TPP transforms into triphenyl phosphate during storage.
  
  
  CONCLUSIONS
  TPP represents a new allergen in PVC gloves. It was detected in several PVC gloves in fairly high concentrations.
authors.affiliation: Finnish Institute of Occupational Health (FIOH), Occupational Medicine, Topeliuksenkatu 41 a A, 00250 Helsinki, Finland. katri.suuronen@ttl.fi
authors.forename: Katri
authors.initials: K
authors.lastname: Suuronen
authors.forename: Maria
authors.initials: M
authors.lastname: Pesonen
authors.forename: Maj-Len
authors.initials: ML
authors.lastname: Henriks-Eckerman
authors.forename: Kristiina
authors.initials: K
authors.lastname: Aalto-Korte
mesh_terms: D000485:Allergens / Q000009:adverse effects*; D017449:Dermatitis, Allergic Contact / Q000175:diagnosis / Q000209:etiology*; D009783:Dermatitis, Occupational / Q000209:etiology*; D005260:Female; D017575:Gloves, Protective / Q000009:adverse effects*; D006229:Hand Dermatoses / Q000139:chemically induced* / Q000175:diagnosis; D006801:Humans; D010755:Organophosphates / Q000009:adverse effects / Q000032:analysis; D010328:Patch Tests; D017905:Phosphites / Q000009:adverse effects* / Q000032:analysis; D011143:Polyvinyl Chloride / Q000009:adverse effects*
chemical_list: D000485:Allergens; D010755:Organophosphates; D017905:Phosphites; D011143:Polyvinyl Chloride; C013318:triphenyl phosphite; C005445:triphenyl phosphate