title: Clindamycin-induced neutropenia following major head and neck surgery.
abstract: A 64-year-old man undergoing major head and neck surgery received clindamycin for perioperative antimicrobial prophylaxis. On the third postoperative day, he became acutely neutropenic. The neutropenia resolved 3 days later, after the administration of filgrastim. After ruling out other causes of acute neutropenia, we determined that the neutropenia was secondary to clindamycin toxicity. While clindamycin-induced neutropenia has been reported elsewhere, to our knowledge this is the first report of its occurrence following head and neck surgery. Otolaryngologists should be aware of this potentially serious reaction.
authors.affiliation: Department of Otolaryngology-Head and Neck Surgery, Virginia Commonwealth University, Richmond, VA, 23298-0146, USA. robert_s_schmidt@hotmail.com
authors.forename: Robert S
authors.initials: RS
authors.lastname: Schmidt
authors.forename: Evan R
authors.initials: ER
authors.lastname: Reiter
mesh_terms: D000900:Anti-Bacterial Agents / Q000009:adverse effects*; D019072:Antibiotic Prophylaxis; D002294:Carcinoma, Squamous Cell / Q000601:surgery; D002981:Clindamycin / Q000009:adverse effects*; D000069585:Filgrastim; D016179:Granulocyte Colony-Stimulating Factor / Q000627:therapeutic use; D006258:Head and Neck Neoplasms / Q000601:surgery; D006801:Humans; D008297:Male; D008875:Middle Aged; D009503:Neutropenia / Q000139:chemically induced* / Q000188:drug therapy; D013517:Otorhinolaryngologic Surgical Procedures; D011183:Postoperative Complications; D011994:Recombinant Proteins / Q000627:therapeutic use; D000077195:Squamous Cell Carcinoma of Head and Neck
chemical_list: D000900:Anti-Bacterial Agents; D011994:Recombinant Proteins; D016179:Granulocyte Colony-Stimulating Factor; D002981:Clindamycin; D000069585:Filgrastim