title: Plasma antibodies to oral bacteria and risk of pancreatic cancer in a large European prospective cohort study.
abstract: OBJECTIVE
  Examine the relationship between antibodies to 25 oral bacteria and pancreatic cancer risk in a prospective cohort study.
  
  
  METHODS
  We measured antibodies to oral bacteria in prediagnosis blood samples from 405 pancreatic cancer cases and 416 matched controls, nested within the European Prospective Investigation into Cancer and Nutrition study. Analyses were conducted using conditional logistic regression and additionally adjusted for smoking status and body mass index.
  
  
  RESULTS
  Individuals with high levels of antibodies against Porphyromonas gingivalis ATTC 53978, a pathogenic periodontal bacteria, had a twofold higher risk of pancreatic cancer than individuals with lower levels of these antibodies (OR 2.14; 95% CI 1.05 to 4.36; >200 ng/ml vs ≤200 ng/ml). To explore the association with commensal (non-pathogenic) oral bacteria, we performed a cluster analysis and identified two groups of individuals, based on their antibody profiles. A cluster with overall higher levels of antibodies had a 45% lower risk of pancreatic cancer than a cluster with overall lower levels of antibodies (OR 0.55; 95% CI 0.36 to 0.83).
  
  
  CONCLUSIONS
  Periodontal disease might increase the risk for pancreatic cancer. Moreover, increased levels of antibodies against specific commensal oral bacteria, which can inhibit growth of pathogenic bacteria, might reduce the risk of pancreatic cancer. Studies are needed to determine whether oral bacteria have direct effects on pancreatic cancer pathogenesis or serve as markers of the immune response.
authors.affiliation: Department of Epidemiology, Division of Biology and Medicine, Brown University, Providence, Rhode Island, USA.
authors.forename: Dominique S
authors.initials: DS
authors.lastname: Michaud
authors.forename: Jacques
authors.initials: J
authors.lastname: Izard
authors.forename: Charlotte S
authors.initials: CS
authors.lastname: Wilhelm-Benartzi
authors.forename: Doo-Ho
authors.initials: DH
authors.lastname: You
authors.forename: Verena A
authors.initials: VA
authors.lastname: Grote
authors.forename: Anne
authors.initials: A
authors.lastname: Tjønneland
authors.forename: Christina C
authors.initials: CC
authors.lastname: Dahm
authors.forename: Kim
authors.initials: K
authors.lastname: Overvad
authors.forename: Mazda
authors.initials: M
authors.lastname: Jenab
authors.forename: Veronika
authors.initials: V
authors.lastname: Fedirko
authors.forename: Marie Christine
authors.initials: MC
authors.lastname: Boutron-Ruault
authors.forename: Françoise
authors.initials: F
authors.lastname: Clavel-Chapelon
authors.forename: Antoine
authors.initials: A
authors.lastname: Racine
authors.forename: Rudolf
authors.initials: R
authors.lastname: Kaaks
authors.forename: Heiner
authors.initials: H
authors.lastname: Boeing
authors.forename: Jana
authors.initials: J
authors.lastname: Foerster
authors.forename: Antonia
authors.initials: A
authors.lastname: Trichopoulou
authors.forename: Pagona
authors.initials: P
authors.lastname: Lagiou
authors.forename: Dimitrios
authors.initials: D
authors.lastname: Trichopoulos
authors.forename: Carlotta
authors.initials: C
authors.lastname: Sacerdote
authors.forename: Sabina
authors.initials: S
authors.lastname: Sieri
authors.forename: Domenico
authors.initials: D
authors.lastname: Palli
authors.forename: Rosario
authors.initials: R
authors.lastname: Tumino
authors.forename: Salvatore
authors.initials: S
authors.lastname: Panico
authors.forename: Peter D
authors.initials: PD
authors.lastname: Siersema
authors.forename: Petra H M
authors.initials: PH
authors.lastname: Peeters
authors.forename: Eiliv
authors.initials: E
authors.lastname: Lund
authors.forename: Aurelio
authors.initials: A
authors.lastname: Barricarte
authors.forename: José-María
authors.initials: JM
authors.lastname: Huerta
authors.forename: Esther
authors.initials: E
authors.lastname: Molina-Montes
authors.forename: Miren
authors.initials: M
authors.lastname: Dorronsoro
authors.forename: J Ramón
authors.initials: JR
authors.lastname: Quirós
authors.forename: Eric J
authors.initials: EJ
authors.lastname: Duell
authors.forename: Weimin
authors.initials: W
authors.lastname: Ye
authors.forename: Malin
authors.initials: M
authors.lastname: Sund
authors.forename: Björn
authors.initials: B
authors.lastname: Lindkvist
authors.forename: Dorthe
authors.initials: D
authors.lastname: Johansen
authors.forename: Kay-Tee
authors.initials: KT
authors.lastname: Khaw
authors.forename: Nick
authors.initials: N
authors.lastname: Wareham
authors.forename: Ruth C
authors.initials: RC
authors.lastname: Travis
authors.forename: Paolo
authors.initials: P
authors.lastname: Vineis
authors.forename: H Bas
authors.initials: HB
authors.lastname: Bueno-de-Mesquita
authors.forename: Elio
authors.initials: E
authors.lastname: Riboli
mesh_terms: D000328:Adult; D000368:Aged; D000907:Antibodies, Bacterial / Q000097:blood*; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010190:Pancreatic Neoplasms / Q000453:epidemiology / Q000209:etiology*; D010510:Periodontal Diseases / Q000150:complications / Q000382:microbiology; D016966:Porphyromonas gingivalis / Q000276:immunology; D012307:Risk Factors; D014678:Veillonella / Q000276:immunology
chemical_list: D000907:Antibodies, Bacterial