title: [Differentiation potential and application of stem cells from adipose tissue].
abstract: OBJECTIVE
  To introduce types and differentiation potentials of stem cells from adipose tissue, and its applications on regenerative medicine and advantages.
  
  
  METHODS
  The literature of original experimental study and clinical research about bone marrow mesenchymal stem cells (BMSCs), adipose-derived stem cells (ADSCs), and dedifferentiated fat (DFAT) cells was extensively reviewed and analyzed.
  
  
  RESULTS
  ADSCs can be isolated from stromal vascular fraction. As ADSCs have multi-lineage potentials, such as adipogenesis, osteogenesis, chondrogenesis, angiogenesis, myogenesis, and neurogenesis, they have already been successfully used in regenerative medicine areas. Dramatically, mature fat cells can be dedifferentiated and changed into fibroblast-like cells, named DFAT cells, via ceiling culture method. DFAT cells also had the same multi-lineage potentials as ADSCs, differentiating into adipocytes, osteocytes, chondrocytes, endothelial cells, muscle cells, and nerve cells. Compared with BMSCs which are commonly used as adult stem cells, ADSCs and DFAT cells have extensive sources and can be easily acquired. While compared with ADSCs, DFAT cells have good homogeneity and strong proliferation capacity.
  
  
  CONCLUSIONS
  As a potential source of stem cells, adipose tissue will provide a new promising for regenerative medicine.
authors.affiliation: No.2 Clinical Company, Graduate Management Team, Institute of Biomedical Engineering, Second Military Medical University, Shanghai 200433, PR China.
authors.forename: Linli
authors.initials: L
authors.lastname: Shi
authors.forename: Xiangqun
authors.initials: X
authors.lastname: Yang
mesh_terms: D050156:Adipogenesis; D000273:Adipose Tissue / Q000166:cytology* / Q000502:physiology; D000818:Animals; D054337:Cell Dedifferentiation; D019070:Cell Lineage; D002469:Cell Separation; D002478:Cells, Cultured; D020219:Chondrogenesis / Q000502:physiology; D006801:Humans; D059630:Mesenchymal Stem Cells / Q000166:cytology / Q000502:physiology; D039902:Multipotent Stem Cells; D010012:Osteogenesis / Q000502:physiology; D044968:Regenerative Medicine; D013234:Stem Cells / Q000145:classification / Q000166:cytology* / Q000502:physiology; D017154:Stromal Cells / Q000166:cytology* / Q000502:physiology; D023822:Tissue Engineering / Q000379:methods