title: Altered microstructure of white matter except the corpus callosum is independent of prematurity.
abstract: BACKGROUND
  Diffusion tensor imaging (DTI) reflects the maturation of the brain microstructure. Although preterm infants are at significant risk for altered brain microstructure, it remains unclear whether this is affected by prematurity itself or other clinical factors.
  
  
  OBJECTIVE
  To investigate DTI parameters in preterm infants at a term-equivalent age (TEA) compared with healthy term infants and to assess the associations between DTI parameters and clinical factors that may affect brain development.
  
  
  METHODS
  We studied 34 preterm infants without apparent brain lesions and 12 healthy term infants using tract-based spatial statistics. Region-of-interest analysis was performed in the posterior and anterior limbs of the internal capsule (PLIC and ALIC), corpus callosum (CC), optic radiation, and cerebral peduncle.
  
  
  RESULTS
  Preterm infants had significantly decreased fractional anisotropy (FA) in nearly the entire white matter (WM) compared with term infants (p < 0.01). Multiple regression analysis showed that FA in the PLIC, ALIC, optic radiation, and cerebral peduncle were positively associated with postmenstrual age (PMA) at imaging and that the apparent diffusion coefficient was negatively associated with PMA. Only FA in the CC was positively correlated with gestational age. Chronic lung disease (CLD) and postnatal infection were associated with decreased FA in the CC and PLIC, respectively.
  
  
  CONCLUSIONS
  Preterm infants at TEA showed an altered microstructure of the WM compared with healthy term infants. The altered microstructure of the measured WM except the CC was independent of the degree of prematurity. Chronic lung disease and postnatal infection are related to localized WM alterations.
authors.affiliation: Division of Neonatology, Gachon University Gil Hospital, Incheon, Korea.
authors.forename: So-Yeon
authors.initials: SY
authors.lastname: Shim
authors.forename: Hye-Jin
authors.initials: HJ
authors.lastname: Jeong
authors.forename: Dong Woo
authors.initials: DW
authors.lastname: Son
authors.forename: Joon Sup
authors.initials: JS
authors.lastname: Jeong
authors.forename: Se Hong
authors.initials: SH
authors.lastname: Oh
authors.forename: Sung-Yeon
authors.initials: SY
authors.lastname: Park
authors.forename: Taek-Hyun
authors.initials: TH
authors.lastname: Ryu
authors.forename: Young-Bo
authors.initials: YB
authors.lastname: Kim
authors.forename: Zang-Hee
authors.initials: ZH
authors.lastname: Cho
mesh_terms: D016880:Anisotropy; D001424:Bacterial Infections / Q000150:complications / Q000473:pathology; D001724:Birth Weight; D003337:Corpus Callosum / Q000254:growth & development* / Q000473:pathology; D038524:Diffusion Magnetic Resonance Imaging / Q000379:methods; D020345:Enterocolitis, Necrotizing / Q000150:complications / Q000473:pathology; D005260:Female; D005865:Gestational Age; D006801:Humans; D007231:Infant, Newborn / Q000254:growth & development*; D007234:Infant, Premature / Q000254:growth & development*; D007969:Leukomalacia, Periventricular / Q000150:complications / Q000473:pathology; D055370:Lung Injury / Q000150:complications / Q000473:pathology; D008297:Male; D009413:Nerve Fibers, Myelinated / Q000473:pathology / Q000502:physiology*; D047929:Term Birth