title: Kaposi's sarcoma-associated herpesvirus ORF57 is not a bona fide export factor.
abstract: Kaposi's sarcoma-associated herpesvirus (KSHV [human herpesvirus 8; HHV-8]) open reading frame 57 (ORF57) is a viral early protein participating in posttranscriptional regulatory events, such as splicing, RNA stabilization, and protein expression. Recent data suggest that ORF57 recruits the transcription and export (TREX) complex to viral RNA and exports these transcripts to the cytoplasm. In this study, we show that although ORF57 promotes expression of a selection of KSHV viral intronless RNAs, it is not a bona fide export factor.
authors.affiliation: Human Retrovirus Pathogenesis Section, Vaccine Branch, Center for Cancer Research, Frederick National Laboratory for Cancer Research, Frederick, Maryland, USA.
authors.forename: Guy R
authors.initials: GR
authors.lastname: Pilkington
authors.forename: Vladimir
authors.initials: V
authors.lastname: Majerciak
authors.forename: Jenifer
authors.initials: J
authors.lastname: Bear
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Uranishi
authors.forename: Zhi-Ming
authors.initials: ZM
authors.lastname: Zheng
authors.forename: Barbara K
authors.initials: BK
authors.lastname: Felber
mesh_terms: D021581:Active Transport, Cell Nucleus / Q000235:genetics / Q000502:physiology; D015152:Blotting, Northern; D002467:Cell Nucleus / Q000378:metabolism*; D019288:Herpesvirus 8, Human / Q000235:genetics*; D009841:Oligonucleotides / Q000235:genetics; D016366:Open Reading Frames / Q000235:genetics; D012323:RNA Processing, Post-Transcriptional / Q000235:genetics*; D012367:RNA, Viral / Q000378:metabolism*; D014764:Viral Proteins / Q000235:genetics* / Q000378:metabolism
chemical_list: D009841:Oligonucleotides; D012367:RNA, Viral; D014764:Viral Proteins