title: Recent updates in redox regulation and free radical scavenging effects by herbal products in experimental models of Parkinson's disease.
abstract: Parkinson's disease (PD) is a complex multifactorial disease marked by extensive neuropathology in the brain with selective yet prominent and progressive loss of mid-brain dopaminergic neurons. The etiological factors involved in the development of PD are still elusive, but oxidative stress arising when reactive oxygen species (ROS) exceed amounts required for normal redox signaling is considered one of the major factors. ROS cause oxidative damage to proteins, lipids, and DNA and are one of the most prominent factors related to neurodegeneration. Pre-clinical and clinical studies clearly demonstrate the effectiveness of oxidative stress in the pathogenesis of PD. Therefore, regulation of redox signaling and inhibiting excess ROS would contribute greatly not only to extend longevity but also to ameliorate the progression of dopaminergic cell death seen in patients with PD. Several herbal products are beneficial for maintaining nerve cell function and for treating various neurodegenerative disorders by reducing oxidative stress. Here, we summarize the recent knowledge concerning promising herbs that have shown significant beneficial effects based on regulation of redox status and ROS inhibition in toxin-induced PD models.
authors.affiliation: Department of Biotechnology, Konkuk University, Chungju, Korea.
authors.forename: Sushruta
authors.initials: S
authors.lastname: Koppula
authors.forename: Hemant
authors.initials: H
authors.lastname: Kumar
authors.forename: Sandeep Vasant
authors.initials: SV
authors.lastname: More
authors.forename: Hyung-Woo
authors.initials: HW
authors.lastname: Lim
authors.forename: Soon-Min
authors.initials: SM
authors.lastname: Hong
authors.forename: Dong-Kug
authors.initials: DK
authors.lastname: Choi
mesh_terms: D000818:Animals; D002470:Cell Survival / Q000187:drug effects; D004195:Disease Models, Animal; D016166:Free Radical Scavengers / Q000494:pharmacology* / Q000627:therapeutic use; D006801:Humans; D019636:Neurodegenerative Diseases / Q000188:drug therapy / Q000378:metabolism; D009474:Neurons / Q000187:drug effects / Q000378:metabolism; D018696:Neuroprotective Agents / Q000494:pharmacology* / Q000627:therapeutic use; D010084:Oxidation-Reduction; D018384:Oxidative Stress; D010300:Parkinson Disease / Q000188:drug therapy / Q000378:metabolism*; D010946:Plants, Medicinal; D015398:Signal Transduction / Q000187:drug effects
chemical_list: D016166:Free Radical Scavengers; D018696:Neuroprotective Agents