title: Vitamin B₁₂ derivatives as activators of soluble guanylyl cyclase.
abstract: Various newly prepared and previously known vitamin B₁₂ derivatives have been studied as potential soluble guanylyl cyclase (sGC) activators. All compounds tested were found to activate the sGC enzyme, although to differing extents. The best results were obtained with the derivatives synthesized from c-lactone and possessing aliphatic amides in the c- and d-positions.
authors.affiliation: Institute of Organic Chemistry PAS, Kasprzaka 44/52, 01-224 Warsaw, Poland.
authors.forename: Keith
authors.initials: K
authors.lastname: ó Proinsias
authors.forename: Daniel T
authors.initials: DT
authors.lastname: Gryko
authors.forename: Yoshio
authors.initials: Y
authors.lastname: Hisaeda
authors.forename: Emil
authors.initials: E
authors.lastname: Martin
authors.forename: Jonathan L
authors.initials: JL
authors.lastname: Sessler
authors.forename: Dorota
authors.initials: D
authors.lastname: Gryko
mesh_terms: D000577:Amides / Q000138:chemical synthesis / Q000737:chemistry; D020536:Enzyme Activators / Q000138:chemical synthesis* / Q000737:chemistry; D006162:Guanylate Cyclase / Q000737:chemistry*; D006801:Humans; D007783:Lactones / Q000138:chemical synthesis* / Q000737:chemistry; D018160:Receptors, Cytoplasmic and Nuclear / Q000737:chemistry*; D000071756:Soluble Guanylyl Cyclase; D013329:Structure-Activity Relationship; D014805:Vitamin B 12 / Q000031:analogs & derivatives* / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D000577:Amides; D020536:Enzyme Activators; D007783:Lactones; D018160:Receptors, Cytoplasmic and Nuclear; D006162:Guanylate Cyclase; D000071756:Soluble Guanylyl Cyclase; D014805:Vitamin B 12