title: Intracranial Meningiomas, WHO Grade Il : Prognostic Implications of Clinicopathologic Features.
abstract: OBJECTIVE
  Intracranial meningiomas are primarily benign tumors with a good prognosis. Although WHO grade II meningiomas are rare (2-10%), WHO grade II meningiomas have higher recurrence and mortality rates than benign. We evaluated the patient recurrence rate and investigated the prognostic factors of WHO grade II meningiomas.
  
  
  METHODS
  Between 1993 and 2005, 55 patients were diagnosed with WHO grade II meningiomas in our hospital. WHO grade II meningiomas (n=55) were compared with other WHO grades meningiomas (I, n=373; and III, n=20). The patients had a median age of 48.4 years (range, 14-17 years), a male-to-female ratio of 26 : 29, and a mean follow-up time of 45 months (range, 3-175 months).
  
  
  RESULTS
  In WHO grade II meningiomas, only the extent of resection was a significant prognostic factor. Post-operative radiotherapy had no significant influence on tumor recurrence (p=0.053). The relative risk of recurrence was significantly higher in WHO grade II meningiomas with incomplete resection (10/27, RR=37%) than in WHO grade II meningiomas with complete resection (4/28, RR=14%) regardless of post-operative radiotherapy. In the incomplete resection group, Simpson grade III or IV had a significantly high risk of recurrence regardless of post-operative RT (n=3, RR=100%) However, if the degree of resection was Simpson grade II, the recurrence rate was similar to the complete resection group even though post-operative RT was not performed.
  
  
  CONCLUSIONS
  Complete resection was the most powerful independent predictive factor of the recurrence rate in WHO grade II meningiomas. Post-operative adjuvant RT was not a significant factor in this study.
authors.affiliation: Department of Neurosurgery, Chonnam National University Research Institute of Medical Sciences, Chonnam National University Hwasun Hospital & Medical School, Gwangju, Korea.
authors.forename: Hyung-Sik
authors.initials: HS
authors.lastname: Moon
authors.forename: Shin
authors.initials: S
authors.lastname: Jung
authors.forename: Woo-Youl
authors.initials: WY
authors.lastname: Jang
authors.forename: Tae-Young
authors.initials: TY
authors.lastname: Jung
authors.forename: Kyung-Sub
authors.initials: KS
authors.lastname: Moon
authors.forename: In-Young
authors.initials: IY
authors.lastname: Kim