title: The effects of BleedArrest on hemorrhage control in a porcine model.
abstract: The purpose of this study was to examine the effectiveness of the hemostatic agent BleedArrest compared to control. This was a prospective, experimental design employing an established porcine model of uncontrolled hemorrhage. The minimum number of animals (n=10 per group) was used to obtain a statistically valid result. There were no statistically significant differences between the groups (P>.05) indicating that the groups were equivalent on the following parameters: activating clotting time, the subject weights, core body temperatures, amount of one minute hemorrhage, arterial blood pressures, and the amount and percentage of total blood volume. There were significant differences in the amount of hemorrhage (P=.033) between the BleedArrest (mean=72, SD±72 mL) and control (mean=317.30, SD±112.02 mL). BleedArrest is statistically and clinically superior at controlling hemorrhage compared to the standard pressure dressing control group. In conclusion, BleedArrest is an effective hemostatic agent for use in civilian and military trauma management.
authors.affiliation: Veteran Anesthesia Services, PLLC, San Antonio, Texas, USA.
authors.forename: Brian
authors.initials: B
authors.lastname: Gegel
authors.forename: James
authors.initials: J
authors.lastname: Burgert
authors.forename: Michael
authors.initials: M
authors.lastname: Loughren
authors.forename: Don
authors.initials: D
authors.lastname: Johnson
mesh_terms: D000818:Animals; D008297:Male; D004195:Disease Models, Animal; D005263:Femoral Artery / Q000293:injuries; D005268:Femoral Vein / Q000293:injuries; D006470:Hemorrhage / Q000517:prevention & control; D006490:Hemostatics / Q000627:therapeutic use; D011446:Prospective Studies; D013552:Swine
chemical_list: D006490:Hemostatics