title: Biologically responsive polymeric nanoparticles for drug delivery.
abstract: Responsive nanoparticles that release their drug cargo in accordance with a change in pH or oxidative stress are of significant clinical interest as this approach offers the opportunity to link drug delivery to a specific location or disease state. This research news article reviews the current state of this field by examining a series of published articles that highlight the novelty and benefits of using responsive polymeric particles to achieve functionally-targeted drug delivery.
authors.affiliation: Division of Thoracic Surgery, Department of Surgery, Brigham and Women's Hospital, Boston MA 02215, USA. Yolonda_Colson@dfci.harvard.edu
authors.forename: Yolonda L
authors.initials: YL
authors.lastname: Colson
authors.forename: Mark W
authors.initials: MW
authors.lastname: Grinstaff
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage; D001672:Biocompatible Materials / Q000737:chemistry; D004337:Drug Carriers / Q000737:chemistry; D016503:Drug Delivery Systems; D006801:Humans; D006863:Hydrogen-Ion Concentration; D008422:Materials Testing; D053758:Nanoparticles / Q000737:chemistry*; D036103:Nanotechnology; D009374:Neoplasms, Experimental / Q000188:drug therapy; D018384:Oxidative Stress; D011108:Polymers / Q000737:chemistry
chemical_list: D000970:Antineoplastic Agents; D001672:Biocompatible Materials; D004337:Drug Carriers; D011108:Polymers