title: A new flavan-3-ol lactone and other constituents from Euonymus alatus with inhibitory activities on α-glucosidase and differentiation of 3T3-L1 cells.
abstract: Bioassay-guided fractionation, based on inhibition of α-glucosidase, of Euonymus alatus led to the isolation of a new compound, catechin lactone A (7), and seven known compounds (1-6 and 8). Their structures were established on the basis of extensive 1D- and 2D-NMR experiments. The absolute configurations of compound 7 have been determined using vibrational circular dichroism spectroscopy. All these compounds were evaluated for their inhibition activities on α-glucosidase and differentiation of 3T3-L1 cells. Compounds 1, 3-5, 7 and 8 showed potent yeast α-glucosidase inhibition with IC50 values of 119.1, 39.6, 31.6, 23.0, 71.8 and 102.5 µM, respectively; compounds 3-5, 7 and 8 can remarkably inhibit the differentiation of 3T3-L1 pre-adipocytes. This is the first report about α-glucosidase and 3T3-L1 inhibitory activities of compounds 3, 7 and 8.
authors.affiliation: College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310027, China.
authors.forename: Yufeng
authors.initials: Y
authors.lastname: Zhang
authors.forename: Gongduan
authors.initials: G
authors.lastname: Xiao
authors.forename: Lijuan
authors.initials: L
authors.lastname: Sun
authors.forename: Yingchao
authors.initials: Y
authors.lastname: Wang
authors.forename: Yi
authors.initials: Y
authors.lastname: Wang
authors.forename: Yi
authors.initials: Y
authors.lastname: Wang
mesh_terms: D041721:3T3-L1 Cells; D000818:Animals; D002454:Cell Differentiation / Q000187:drug effects; D029756:Euonymus / Q000737:chemistry*; D005419:Flavonoids / Q000737:chemistry*; D007783:Lactones / Q000737:chemistry / Q000494:pharmacology; D051379:Mice; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology; D000520:alpha-Glucosidases / Q000378:metabolism*
chemical_list: D005419:Flavonoids; D007783:Lactones; D010936:Plant Extracts; C404987:flavan-3-ol; D000520:alpha-Glucosidases