title: Robustness of signal transduction pathways.
abstract: Signal transduction pathways transduce information about the outside of the cell to the nucleus, regulating gene expression and cell fate. To reliably inform the cell about its surroundings, information transfer has to be robust against typical perturbation that a cell experiences. Robustness of several mammalian signaling pathways has been studied recently by quantitative experimentation and using mathematical modeling. Here, we review these studies, and describe the emerging concepts of robustness and the underlying mechanisms.
authors.affiliation: Institute of Pathology, Charité Universitätsmedizin Berlin, Charitéplatz 1, 10117 Berlin, Germany. nils.bluethgen@charite.de
authors.forename: Nils
authors.initials: N
authors.lastname: Blüthgen
authors.forename: Stefan
authors.initials: S
authors.lastname: Legewie
mesh_terms: D000818:Animals; D019485:Bone Morphogenetic Proteins / Q000378:metabolism*; D025461:Feedback, Physiological; D020935:MAP Kinase Signaling System / Q000502:physiology; D008962:Models, Theoretical; D015398:Signal Transduction
chemical_list: D019485:Bone Morphogenetic Proteins