title: [A same deficit of cognitive inhibition in early and late-onset depression in elderly women: a pilot study].
abstract: OBJECTIVE
  Late-life depression has been associated with frontostriatal abnormalities that are thought to lead to deficits of cognitive inhibition. However, it remains unclear, whether age-of-onset identifies subgroups of depression. The objective of this study was to compare cognitive inhibition in depressed women aged 60 and older, according to age of the first onset depression (before or after 60 years old).
  
  
  METHODS
  We compared 10 currently depressed women (HDRS-17≥18) with a late-onset depression to 10 depressed women with an early-onset depression, and to 10 healthy controls. We examined cognitive inhibition (Stroop, Hayling, Go/No-Go), shifting (TMT), updating in working memory (WAIS) and executive functions (BREF). All groups were matched for age, education level, and MMSE score (MMSE≥24).
  
  
  RESULTS
  Depressed elderly women with a late and an early-onset depression had a greater impairment in executive functions and cognitive inhibition compared with healthy controls (p<0,001), but without significant differences according to the age of the first onset depression. Futhermore, late-onset depression in women was significantly correlated with a deficit of cognitive inhibition (rs=0.55; p=0.012).
  
  
  CONCLUSIONS
  Cognitive inhibition should be assessed in late-life depression. Interventions may be developed to specifically target cognitive impairment in the prevention of late-life depression, to identify those who are the most vulnerable to relapse.
authors.affiliation: Centre de santé mentale angevin Cesame 27, Sainte-Gemmes-sur-Loire, France.
authors.forename: Florence
authors.initials: F
authors.lastname: Deguigne
authors.forename: Fabrice
authors.initials: F
authors.lastname: Jollant
authors.forename: Jean-Paul
authors.initials: JP
authors.lastname: Lhuillier
authors.forename: Jean-Bernard
authors.initials: JB
authors.lastname: Garre
authors.forename: Stéphane
authors.initials: S
authors.lastname: Richard-Devantoy
mesh_terms: D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D060825:Cognitive Dysfunction / Q000175:diagnosis* / Q000523:psychology*; D003866:Depressive Disorder / Q000175:diagnosis / Q000523:psychology*; D056344:Executive Function; D005260:Female; D006801:Humans; D007266:Inhibition, Psychological; D008570:Memory, Short-Term; D008609:Mental Status Schedule; D008875:Middle Aged; D009483:Neuropsychological Tests; D010865:Pilot Projects; D012307:Risk Factors; D057190:Stroop Test