title: Serial measurements of accommodation by open-field Hartmann-Shack wavefront aberrometer in eyes with accommodative spasm.
abstract: OBJECTIVE
  To investigate the serial changes of accommodation and spherical aberration in eyes with accommodative spasm.
  
  
  METHODS
  Four patients with accommodative spasm and ten healthy subjects were studied. The ocular refractive power (spherical equivalent) and spherical aberration were measured serially with an open-field, binocular Hartmann-Shack wavefront aberrometer. Patients and subjects wore full-correction lenses and were instructed to fixate a target set at 50 cm from the eye. The time-average of the refractive power, spherical aberration, and fluctuations of accommodation analyzed by the fast Fourier transform (FFT) of the two groups were compared.
  
  
  RESULTS
  The average ± standard deviation refractive power in the patients was significantly more negative than that in the healthy subject (-3.12 ± 1.06 vs. -1.49 ± 0.17 D). The integrated intensity of the FFT from 1 to 4 Hz was significantly higher in the patients than in the healthy subjects. The spherical aberration in patients was more negative than that in the healthy subjects (-0.033 ± 0.048 μm vs. 0.002 ± 0.027 μm).
  
  
  CONCLUSIONS
  Eyes with accommodative spasm are characterized by a lead of accommodation with greater fluctuations and negative spherical aberrations. Excessive accommodation can be measured objectively in such eyes with a binocular wavefront aberrometer without cycloplegics.
authors.affiliation: Department of Applied Visual Science, Osaka University Graduate School of Medicine, Suita, Osaka, Japan.
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Kanda
authors.forename: Mariko
authors.initials: M
authors.lastname: Kobayashi
authors.forename: Toshifumi
authors.initials: T
authors.lastname: Mihashi
authors.forename: Takeshi
authors.initials: T
authors.lastname: Morimoto
authors.forename: Kohji
authors.initials: K
authors.lastname: Nishida
authors.forename: Takashi
authors.initials: T
authors.lastname: Fujikado
mesh_terms: D057128:Aberrometry / Q000295:instrumentation*; D000065:Accommodation, Ocular; D000293:Adolescent; D000328:Adult; D057108:Corneal Wavefront Aberration / Q000175:diagnosis*; D005260:Female; D006801:Humans; D009184:Mydriatics / Q000008:administration & dosage; D009216:Myopia / Q000175:diagnosis*; D011680:Pupil / Q000187:drug effects; D012029:Refraction, Ocular / Q000502:physiology; D013035:Spasm / Q000175:diagnosis*; D014331:Tropicamide / Q000008:administration & dosage; D015348:Vision, Binocular / Q000502:physiology; D014792:Visual Acuity / Q000502:physiology; D055815:Young Adult
chemical_list: D009184:Mydriatics; D014331:Tropicamide