title: The joint effect of smoking and hOGG1 genotype on oral cancer in Taiwan.
abstract: This study aimed at evaluating the association and interaction among human 8-oxoguanine DNA N-glycosylase 1 (hOGG1) genotypic polymorphism, smoking status and oral cancer risk in Taiwan. For this purpose, the well-known polymorphic variants of hOGG1, codon 326, was analyzed for its association with oral cancer susceptibility, and its joint effect with individual smoking habits on oral cancer susceptibility. In total, 620 patients with oral cancer and 620 healthy controls were recruited from the China Medical Hospital and genotyped. The results showed that the hOGG1 codon 326 genotypes were differently distributed between the oral cancer and control groups (p=0.0266), with the C allele of hOGG1 codon 326 being significantly (p=0.0046) more frequently found in cancer patients than in controls. We further analyzed the genetic-smoking joint effects on oral cancer risk and found an interaction between hOGG1 codon 326 genotypes and smoking status. The hOGG1 codon 326 CC genotype was associated with oral cancer risk only in the smoker group (p=0.0198), but not in the non-chewer group (p=0.8357). Our results provide evidence that the C allele of hOGG1 codon 326 may have a joint effect with smoking on the development of oral cancer.
authors.affiliation: Graduate Institutes of Basic Medical Science,China Medical University, Taichung, Taiwan, ROC.
authors.forename: Chia-Wen
authors.initials: CW
authors.lastname: Tsai
authors.forename: Ming-Hsui
authors.initials: MH
authors.lastname: Tsai
authors.forename: Yung-An
authors.initials: YA
authors.lastname: Tsou
authors.forename: Liang-Chun
authors.initials: LC
authors.lastname: Shih
authors.forename: Hsien-Chang
authors.initials: HC
authors.lastname: Tseng
authors.forename: Wen-Shin
authors.initials: WS
authors.lastname: Chang
authors.forename: Chien-Yi
authors.initials: CY
authors.lastname: Ho
authors.forename: Hong-Zin
authors.initials: HZ
authors.lastname: Lee
authors.forename: Da-Tian
authors.initials: DT
authors.lastname: Bau
mesh_terms: D000483:Alleles; D016022:Case-Control Studies; D003043:Cocarcinogenesis; D003062:Codon; D045647:DNA Glycosylases / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D009062:Mouth Neoplasms / Q000201:enzymology / Q000209:etiology* / Q000235:genetics; D016133:Polymerase Chain Reaction; D012150:Polymorphism, Restriction Fragment Length; D020641:Polymorphism, Single Nucleotide; D012907:Smoking / Q000009:adverse effects* / Q000235:genetics / Q000378:metabolism; D013624:Taiwan
chemical_list: D003062:Codon; D045647:DNA Glycosylases; C479058:oxoguanine glycosylase 1, human