title: Mast Cell Leukaemia: c-KIT Mutations Are Not Always Positive.
abstract: Mast cell leukemia (MCL) is a rare and aggressive disease with poor prognosis and short survival time. D816V c-KIT mutation is the most frequent molecular abnormality and plays a crucial role in the pathogenesis and development of the disease. Thus, comprehensive diagnostic investigations and molecular studies should be carefully carried out to facilitate the therapeutic choice. A MCL patient's case with rare phenotypic and genotypic characteristics is described with review of major clinical biological and therapeutic approaches in MCL.
authors.affiliation: Service d'Hématologie, Centre Hospitalier Universitaire, Avenue Laennec, 80054 Amiens, France.
authors.forename: Magalie
authors.initials: M
authors.lastname: Joris
authors.forename: Sophie
authors.initials: S
authors.lastname: Georgin-Lavialle
authors.forename: Marie-Olivia
authors.initials: MO
authors.lastname: Chandesris
authors.forename: Ludovic
authors.initials: L
authors.lastname: Lhermitte
authors.forename: Jean-François
authors.initials: JF
authors.lastname: Claisse
authors.forename: Danielle
authors.initials: D
authors.lastname: Canioni
authors.forename: Katia
authors.initials: K
authors.lastname: Hanssens
authors.forename: Gandhi
authors.initials: G
authors.lastname: Damaj
authors.forename: Olivier
authors.initials: O
authors.lastname: Hermine
authors.forename: Mohammed
authors.initials: M
authors.lastname: Hamidou