title: Atrial conduction time and atrial mechanical function in patients with impaired fasting glucose.
abstract: BACKGROUND
  Prolonging atrial conduction time, as measured by tissue Doppler imaging (TDI), is an independent predictor of new onset or recurrent atrial fibrillation (AF). We investigated atrial conduction time and cardiac mechanical function in patients with impaired fasting glucose (IFG) using echocardiography.
  
  
  METHODS
  Thirty patients with IFG (19 males and 11 females; age, 46.9 ± 9.5 years) and 30 control subjects (18 males and 12 females; age, 46.7 ± 8.2 years) were included. Atrial conduction time was determined from the lateral mitral annulus (PA lateral), septal mitral annulus (PA septal), and lateral tricuspid annulus (PA tricuspid) by TDI. Inter- and intra-atrial electromechanical delays (EMDs) were calculated. Left atrial (LA) volumes were determined according to the biplane area-length method. LA mechanical function parameters were calculated.
  
  
  RESULTS
  LA passive emptying volume and LA passive emptying fraction decreased significantly in patients with IFG as compared with control subjects (p < 0.001 and p < 0.001, respectively). PA lateral and PA septal durations were significantly higher in patients with IFG than in the control group. However, no difference in PA tricuspid duration was observed between the two groups. Inter- and intra-atrial EMDs were significantly higher in patients with IFG as compared with the control subjects (median [interquartile range], 34.0 [17.0] vs. 17.0 [4.0], p < 0.001 and 15.0 [8.5] vs. 7.5 [2.0], p < 0.001, respectively). Positive correlations were detected between both inter- and intra-atrial EMD and glucose levels (r = 0.76, p < 0.001 and r = 0.68, p < 0.001, respectively). Additionally, a multiple linear regression analysis revealed that glucose levels were independently associated with inter-atrial EMD (β = 0.753, p < 0.001).
  
  
  CONCLUSIONS
  We showed that IFG was associated with inter- and intra-atrial EMD. Our findings suggest that IFG is an etiological factor for the development of AF.
authors.affiliation: Department of Cardiology, Abant Izzet Baysal University School of Medicine, Gölköy Yerleşkesi, 14280 Bolu, Turkey. ssayhan@yahoo.com
authors.forename: Selim
authors.initials: S
authors.lastname: Ayhan
authors.forename: Serkan
authors.initials: S
authors.lastname: Ozturk
authors.forename: Aytekin
authors.initials: A
authors.lastname: Alcelik
authors.forename: Mehmet Fatih
authors.initials: MF
authors.lastname: Ozlu
authors.forename: Alim
authors.initials: A
authors.lastname: Erdem
authors.forename: Tolga
authors.initials: T
authors.lastname: Memioglu
authors.forename: Mesut
authors.initials: M
authors.lastname: Ozdemir
authors.forename: Mehmet
authors.initials: M
authors.lastname: Yazici
mesh_terms: D016279:Atrial Function, Left / Q000502:physiology*; D001786:Blood Glucose / Q000032:analysis*; D016022:Case-Control Studies; D015150:Echocardiography, Doppler; D004562:Electrocardiography; D005260:Female; D006325:Heart Atria / Q000000981:diagnostic imaging* / Q000503:physiopathology*; D006329:Heart Conduction System / Q000000981:diagnostic imaging* / Q000503:physiopathology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D018709:Statistics, Nonparametric
chemical_list: D001786:Blood Glucose