title: Red cell antioxidant enzymes and prognostic indexes in patients with burns.
abstract: Red cell superoxide dismutase (SOD), glutathione peroxidase (GPX) and catalase (CAT) were measured in 66 burned patients (57 men, 9 women, age 16-78 years). BSAB varied from 15 to 93% and ABSI from 3 to 14 points. In the first week after injury the activity of SOD was significantly decreased as compared with the activity of the enzymes in the control group and was also below the reference values. Later the activity of SOD increased up to the normal range. The activity of CAT followed a similar pattern but the differences were not significant. No significant changes in red cell GPX were found during the monitored period. We did not find any significant association between the antioxidant enzyme activities and the markers of burns severity. On the other side there was a significant indirect association between the change of SOD activity (calculated as a difference between the first week values after the injury and the activities measured later) and BSAB.
authors.affiliation: Clinic of Burns and Reconstructive Surgery, 1st Private Hospital Ltd., SK 04015 Košice - Šaca, Slovakia. efrisman@nemocnicasaca.sk
authors.forename: Eugen
authors.initials: E
authors.lastname: Frišman
authors.forename: Oliver
authors.initials: O
authors.lastname: Rácz
authors.forename: Anna
authors.initials: A
authors.lastname: Chmelárová
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000704:Analysis of Variance; D000975:Antioxidants / Q000378:metabolism*; D015415:Biomarkers / Q000378:metabolism; D002056:Burns / Q000201:enzymology* / Q000473:pathology; D002374:Catalase / Q000378:metabolism*; D004912:Erythrocytes / Q000201:enzymology*; D005260:Female; D005979:Glutathione Peroxidase / Q000378:metabolism*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D013482:Superoxide Dismutase / Q000378:metabolism*; D055815:Young Adult
chemical_list: D000975:Antioxidants; D015415:Biomarkers; D002374:Catalase; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase