title: Remitting seronegative symmetrical synovitis with pitting edema syndrome caused by crystal-induced arthritis of the wrist: a case report.
abstract: OBJECTIVE
  To describe a rare case of remitting seronegative symmetrical synovitis with pitting edema (RS3PE) syndrome caused by gouty arthritis.
  
  
  METHODS
  A 76-year-old man presented with swelling and pain in the dorsum of feet and hands bilaterally. From the laboratory and radiologic findings, the diagnosis of gout-induced RS3PE syndrome was made. Conservative therapy with nonsteroidal anti-inflammatory drugs (NSAIDs) and intra-articular corticosteroid injection in the wrist joint completely and rapidly resolved all symptoms. The patient was successfully treated with oral administration of NSAIDs and a one-time intra-articular corticosteroid injection in the left wrist joint.
  
  
  CONCLUSIONS
  This case demonstrated the importance of considering the possibility of crystal-induced arthritis such as gout and pseudogout, as well as malignant disease, when diagnosing the primary disease responsible for RS3PE syndrome.
authors.affiliation: Department of Orthopaedic Surgery, Fukushima Prefectural Minami-Aizu Hospital, Fukushima, Japan. paco@fmu.ac.jp
authors.forename: Michiyuki
authors.initials: M
authors.lastname: Hakozaki
authors.forename: Hironari
authors.initials: H
authors.lastname: Fukuda
authors.forename: Takahiro
authors.initials: T
authors.lastname: Tajino
authors.forename: Shinichi
authors.initials: S
authors.lastname: Kikuchi
authors.forename: Satoshi
authors.initials: S
authors.lastname: Abe
authors.forename: Shinichi
authors.initials: S
authors.lastname: Konno
mesh_terms: D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D000368:Aged; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use; D015210:Arthritis, Gouty / Q000150:complications*; D004487:Edema / Q000188:drug therapy / Q000453:epidemiology / Q000209:etiology*; D006801:Humans; D007270:Injections, Intra-Articular; D008297:Male; D013577:Syndrome; D013585:Synovitis / Q000188:drug therapy / Q000453:epidemiology / Q000209:etiology*; D014955:Wrist Joint
chemical_list: D000305:Adrenal Cortex Hormones; D000894:Anti-Inflammatory Agents, Non-Steroidal