title: Cutaneous reactions to novel therapeutics.
abstract: In the last 2 decades the introduction new biologic agents such as tumor necrosis factor alpha inhibitors has resulted in potent disease modifying effects in a variety of immune-mediated diseases. In addition, there were major advancements in cancer treatment due to chemotherapeutic agents including granulocyte macrophage-colony-stimulating factor, interferon, epidermal growth factor receptor inhibitors, and kinase inhibitors for the treatment of hematologic malignancies as well as solid tumors. However, a variety of toxicities including cutaneous reactions is seen in association with these agents. Awareness of commonly associated skin toxicities and recognition of corresponding histologic features is of importance.
authors.affiliation: Harvard Medical School and Massachusetts General Hospital, Boston, MA 02114, USA. mhoang@partners.org
authors.forename: Mai P
authors.initials: MP
authors.lastname: Hoang
authors.forename: Daniela
authors.initials: D
authors.lastname: Kroshinsky
mesh_terms: D000328:Adult; D000368:Aged; D000818:Animals; D000970:Antineoplastic Agents / Q000009:adverse effects*; D001688:Biological Products / Q000009:adverse effects*; D001706:Biopsy; D003937:Diagnosis, Differential; D003875:Drug Eruptions / Q000209:etiology* / Q000473:pathology; D005260:Female; D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D012867:Skin / Q000187:drug effects* / Q000473:pathology
chemical_list: D000970:Antineoplastic Agents; D001688:Biological Products; D007166:Immunosuppressive Agents