title: [Selective D1-receptor antagonist SCH23390 decreases maternal reactions in rats upon acute and chronic injections in postpartum period].
abstract: The influence of the D1-receptor antagonist SCH23390 on the maternal behavior of female rats has been studied. It is established that a comparatively high dose of the drug (acute injections) significantly decreases both the locomotor activity and manifestations of the parental care. Lower dosages do not affect the locomotor activity, but still suppress the maternal behavior (after both acute and chronic injections of SCH23390). The obtained results are discussed in terms of the analysis of the maternal motivation mechanisms and the development of the D1-induced postpartum depression.
authors.forename: K K
authors.initials: KK
authors.lastname: Tanaeva
authors.forename: Iu V
authors.initials: IuV
authors.lastname: Dobriakova
authors.forename: V A
authors.initials: VA
authors.lastname: Dubynin
authors.forename: A A
authors.initials: AA
authors.lastname: Kamenskiĭ
mesh_terms: D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects* / Q000502:physiology; D001552:Benzazepines / Q000008:administration & dosage*; D019052:Depression, Postpartum / Q000378:metabolism / Q000503:physiopathology; D004334:Drug Administration Schedule; D005260:Female; D006801:Humans; D007274:Injections, Intraperitoneal; D008425:Maternal Behavior / Q000187:drug effects* / Q000502:physiology; D009043:Motor Activity / Q000187:drug effects* / Q000502:physiology; D049590:Postpartum Period / Q000187:drug effects / Q000502:physiology; D051381:Rats; D017447:Receptors, Dopamine D1 / Q000037:antagonists & inhibitors* / Q000378:metabolism
chemical_list: D001552:Benzazepines; D017447:Receptors, Dopamine D1; C534628:SCH 23390