title: [Genotypes 4 and 5 of the tick-borne encephalitis virus: features of the genome structure and possible scenario for its formation].
abstract: On the basis of the comparison of complete genome structures of 32 strains and gene E fragments (160 ndt) of 643 strains and RNA isolates of tick-borne encephalitis (TBE) virus, we confirmed our previously expressed assumption (Zlobin V.I. et al, 2001) of existence, along with the three major genotypes, of genotypes 4 (strain 178-79) and 5 (strain 886-84). "Mosaic" structure of the polyprotein in the two strains was established. It manifests itself in particular in the sequences of 14 positions (C-3, E-206, NS1-54, NS-285, NS2A-100, NS2A-127, NS2A-174, NS2A-175, NS2A-225, NS3-376, NS4B-28, NS4B-96, NS5-18, NS5-671) containing the amino acids strictly conserved for each of the three major genotypes and is consistent with a uniform pattern of distribution of nucleotide substitutions that are specific for genotypes 1, 2 and 3. Possible scenario of the origin of TBE genotypes 4 and 5 was suggested.
authors.forename: T V
authors.initials: TV
authors.lastname: Demina
authors.forename: Iu P
authors.initials: IuP
authors.lastname: Dzhioev
authors.forename: I V
authors.initials: IV
authors.lastname: Kozlova
authors.forename: M M
authors.initials: MM
authors.lastname: Verkhozina
authors.forename: S E
authors.initials: SE
authors.lastname: Tkachev
authors.forename: E K
authors.initials: EK
authors.lastname: Doroshchenko
authors.forename: O V
authors.initials: OV
authors.lastname: Lisak
authors.forename: A I
authors.initials: AI
authors.lastname: Paramonov
authors.forename: V I
authors.initials: VI
authors.lastname: Zlobin
mesh_terms: D019943:Amino Acid Substitution / Q000235:genetics*; D004669:Encephalitis Viruses, Tick-Borne / Q000145:classification / Q000235:genetics; D004675:Encephalitis, Tick-Borne / Q000821:virology; D019143:Evolution, Molecular; D016679:Genome, Viral; D005838:Genotype; D006801:Humans; D016366:Open Reading Frames / Q000235:genetics*; D010802:Phylogeny