title: The strain-specific dynamics of Escherichia coli O157:H7 faecal shedding in cattle post inoculation.
abstract: This study reports analysis of faecal shedding dynamics in cattle for three Escherichia coli O157:H7 (ECO157) strains (S1, S2 and S3) of different genotype and ecological history, using experimental inoculation data. The three strains were compared for their shedding frequency and level of ECO157 in faeces. A multistate Markov chain model was used to compare shedding patterns of S1 and S2. Strains S1 and S2 were detected seven to eight times more often and at 10(4) larger levels than strain S3. Strains S1 and S2 had similar frequencies and levels of shedding. However, the total time spent in the shedding state during colonization was on average four times longer for S1 (15 days) compared to S2 (4 days). These results indicate that an ECO157 strain effect on the frequency, level, pattern and the duration of faecal shedding may need to be considered in control of ECO157 in the cattle reservoir.
authors.affiliation: Department of Veterinary Integrative Biosciences , College of Veterinary Medicine and Biomedical Sciences, Texas A&M University, College Station, TX 77843, USA. rgautam@cvm.tamu.edu
authors.forename: R
authors.initials: R
authors.lastname: Gautam
authors.forename: M
authors.initials: M
authors.lastname: Kulow
authors.forename: D
authors.initials: D
authors.lastname: Döpfer
authors.forename: C
authors.initials: C
authors.lastname: Kaspar
authors.forename: T
authors.initials: T
authors.lastname: Gonzales
authors.forename: K M
authors.initials: KM
authors.lastname: Pertzborn
authors.forename: R J
authors.initials: RJ
authors.lastname: Carroll
authors.forename: W
authors.initials: W
authors.lastname: Grant
authors.forename: R
authors.initials: R
authors.lastname: Ivanek
mesh_terms: D000818:Animals; D057138:Bacterial Shedding / Q000502:physiology*; D002417:Cattle; D002418:Cattle Diseases / Q000382:microbiology*; D016001:Confidence Intervals; D004927:Escherichia coli Infections / Q000382:microbiology*; D019453:Escherichia coli O157 / Q000502:physiology*; D005243:Feces / Q000382:microbiology*; D008390:Markov Chains; D008954:Models, Biological; D016016:Proportional Hazards Models; D013997:Time Factors