title: Modified cine inversion recovery pulse sequence for the quantification of myocardial T1 and gadolinium partition coefficient.
abstract: OBJECTIVE
  To optimize and validate a modified cine inversion recovery sequence (MCine-IR) for myocardial T1 quantification and gadolinium partition coefficient (λ(Gd)) estimation at 1.5 T.
  
  
  METHODS
  The original version of the cine inversion recovery sequence was modified to allow fully transverse magnetization recovery between two successive inversion pulses. Sixty heart phases were acquired from a number of heart cycles determined on a patient heart rate basis. Phantom studies were carried out to find the optimal effective TR for myocardial and blood pool T1 quantifications in pre- and postcontrast studies. Four patients with myocardial infarct (MI) and 22 dilated cardiomyopathy (DCM) were investigated, as well as 11 healthy subjects used as controls.
  
  
  RESULTS
  Effective TR was identified to be 5000 msec and 2000 msec, respectively, for pre- and postcontrast studies. A longer precontrast (948 ± 102 msec) and shorter postcontrast (348 ± 27 msec) T1 in ischemic patients relative to DCM (815 ± 98 msec, P = 0.03 and 409 ± 42 msec, P = 0.001) were noted in delayed enhancement (DE) areas. In MI patients λ(Gd) resulted higher than in DCM in DE areas (609 ± 167 vs. 422 ± 52, P = 0.01) but lower in segments not exhibiting DE (355 ± 100 vs. 398 ± 54, P = 0.02).
  
  
  CONCLUSIONS
  It was feasible to measure T1 and λ(Gd) with MCine-IR and the results were in good agreement with the literature.
authors.affiliation: MRI Laboratory, Fondazione G. Monasterio CNR-Regione Toscana, Pisa, Italy. mtmilanesi@gmail.com
authors.forename: Matteo
authors.initials: M
authors.lastname: Milanesi
authors.forename: Andrea
authors.initials: A
authors.lastname: Barison
authors.forename: Vincenzo
authors.initials: V
authors.lastname: Positano
authors.forename: Pier Giorgio
authors.initials: PG
authors.lastname: Masci
authors.forename: Daniele
authors.initials: D
authors.lastname: De Marchi
authors.forename: Luca
authors.initials: L
authors.lastname: Marinelli
authors.forename: Christopher J
authors.initials: CJ
authors.lastname: Hardy
authors.forename: Thomas K
authors.initials: TK
authors.lastname: Foo
authors.forename: Luigi
authors.initials: L
authors.lastname: Landini
authors.forename: Massimo
authors.initials: M
authors.lastname: Lombardi
mesh_terms: D000328:Adult; D000368:Aged; D002311:Cardiomyopathy, Dilated / Q000175:diagnosis / Q000473:pathology; D003287:Contrast Media / Q000494:pharmacology; D003952:Diagnostic Imaging / Q000379:methods; D005260:Female; D005682:Gadolinium / Q000494:pharmacology*; D006321:Heart / Q000503:physiopathology*; D006339:Heart Rate; D006801:Humans; D007091:Image Processing, Computer-Assisted; D019028:Magnetic Resonance Imaging, Cine / Q000379:methods*; D008297:Male; D008875:Middle Aged; D015233:Models, Statistical; D009203:Myocardial Infarction / Q000175:diagnosis / Q000473:pathology; D009206:Myocardium / Q000473:pathology*; D019047:Phantoms, Imaging
chemical_list: D003287:Contrast Media; D005682:Gadolinium