title: Prediction of amyloid-β pathology in amnestic mild cognitive impairment with neuropsychological tests.
abstract: Assessment of disease biomarkers, particularly the in vivo assessment of amyloid-β (Aβ) burden with positron emission tomography (PET), is gradually becoming central to the diagnosis of mild cognitive impairment (MCI) due to Alzheimer's disease (AD). However, the incorporation of biomarker evidence to the diagnostic process is currently restricted mainly to research settings. The identification of memory measures that are associated with Aβ is of clinical relevance as this may enhance the confidence in making a diagnosis of MCI due to AD in clinical settings. Forty one persons with amnestic MCI underwent Aβ imaging with (18)F-Florbetaben PET, magnetic resonance imaging, and a comprehensive neuropsychological assessment. All measures of episodic memory were significantly correlated with Aβ burden, but regression analyses revealed a strong and selective association between story recall and Aβ over and beyond the effects of age, education, global cognition, hippocampal volume, or other memory tests. Analyses of sensitivity and specificity of memory measures to detect high versus low Aβ scans suggested that word-list recall performed better when high sensitivity was preferred, whereas story recall performed better when high specificity was preferred. In conclusion, a measure of story recall may increase the confidence in making a diagnosis of MCI due to AD in clinical settings.
authors.affiliation: Department of Nuclear Medicine, Centre for PET, Austin Health, Melbourne, VIC, Australia. alex.baharfuchs@anu.edu.au
authors.forename: Alex
authors.initials: A
authors.lastname: Bahar-Fuchs
authors.forename: Victor
authors.initials: V
authors.lastname: Villemagne
authors.forename: Kevin
authors.initials: K
authors.lastname: Ong
authors.forename: Gaël
authors.initials: G
authors.lastname: Chetélat
authors.forename: Fiona
authors.initials: F
authors.lastname: Lamb
authors.forename: Cornelia B
authors.initials: CB
authors.lastname: Reininger
authors.forename: Michael
authors.initials: M
authors.lastname: Woodward
authors.forename: Christopher C
authors.initials: CC
authors.lastname: Rowe
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000647:Amnesia / Q000000981:diagnostic imaging* / Q000473:pathology; D000686:Amyloidosis / Q000000981:diagnostic imaging* / Q000473:pathology; D000814:Aniline Compounds; D029681:Arabidopsis Proteins; D015415:Biomarkers / Q000378:metabolism; D060825:Cognitive Dysfunction / Q000000981:diagnostic imaging* / Q000473:pathology; D021983:Cyclophilins; D005260:Female; D005462:Fluorine Radioisotopes; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods / Q000592:standards; D008297:Male; D061212:Memory, Episodic; D008875:Middle Aged; D009483:Neuropsychological Tests / Q000592:standards*; D049268:Positron-Emission Tomography / Q000379:methods / Q000592:standards*; D011237:Predictive Value of Tests; D015800:Protozoan Proteins; D012044:Regression Analysis; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D013267:Stilbenes
chemical_list: D000814:Aniline Compounds; D029681:Arabidopsis Proteins; D015415:Biomarkers; D005462:Fluorine Radioisotopes; D015800:Protozoan Proteins; D013267:Stilbenes; C072098:aginactin protein, Dictyostelium; D021983:Cyclophilins; C515035:ROC1 protein, Arabidopsis; C527756:4-(N-methylamino)-4'-(2-(2-(2-fluoroethoxy)ethoxy)ethoxy)stilbene