title: [Analysis of infection-related mortality after allogeneic hematopoietic stem cell transplantation in patients with refractory/relapse acute leukemia].
abstract: OBJECTIVE
  To investigate infection-related mortality (IRM) after allogeneic hematopoietic stem cell transplantation in patients with refractory/relapse acute leukemia.
  
  
  METHODS
  We conducted a retrospective analysis of 127 patients with refractory/relapse acute leukemia and investigated the incidence, causes and risk factors of IRM.
  
  
  RESULTS
  Sixty-seven of the patients died after the transplantation. The 5-year overall survival and disease-free survival was (35.2∓5.3)% and (30.8∓5.6)% among these patients, respectively. IRM occurred in 28.3% (36/127) of the patients. Multivariate analysis showed that grade II-IV acute graft-versus-host diseases (aGVDH, P=0.049, OR=3.017) and post-transplant invasive fungal infection (P=0.032, OR=3.223) were independent risk factors of IRM.
  
  
  CONCLUSIONS
  As a common cause of transplant-related mortality, IRM is more frequent in cases of refractory/relapse acute leukemia than in cases with a standard risk profile, and effective prophylaxis and treatment of severe GVHD remain currently the primary measures for reducing post-transplant IRM.
authors.affiliation: Department of Hematology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China. lansinglinren@21cn.com
authors.forename: Ren
authors.initials: R
authors.lastname: Lin
authors.forename: Jing
authors.initials: J
authors.lastname: Sun
authors.forename: Yujing
authors.initials: Y
authors.lastname: Mao
authors.forename: Mengxia
authors.initials: M
authors.lastname: Zhao
authors.forename: Qifa
authors.initials: Q
authors.lastname: Liu
authors.forename: Hongsheng
authors.initials: H
authors.lastname: Zhou
authors.forename: Fen
authors.initials: F
authors.lastname: Huang
authors.forename: Xiaoling
authors.initials: X
authors.lastname: Song
authors.forename: Han
authors.initials: H
authors.lastname: Li
authors.forename: Qinghui
authors.initials: Q
authors.lastname: Ma
mesh_terms: D000293:Adolescent; D000328:Adult; D005260:Female; D006086:Graft vs Host Disease / Q000401:mortality*; D018380:Hematopoietic Stem Cell Transplantation / Q000009:adverse effects / Q000401:mortality*; D006801:Humans; D007938:Leukemia / Q000401:mortality* / Q000473:pathology / Q000601:surgery; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D009181:Mycoses / Q000401:mortality*; D012008:Recurrence; D012189:Retrospective Studies; D055815:Young Adult