title: [Paquid 2012: illustration and overview].
abstract: Paquid (personnes âgées quid) is a population-based cohort specifically designed to study the epidemiology of brain aging and dependency in activities of daily living in elderly people. At baseline screening, 3.777 subjects older than 65 were randomly selected in 75 different parishes from Gironde and Dordogne, and two administrative districts around Bordeaux in South-Western France. The participation rate was 68%. Subjects were followed up every two to three years with repeated measures of cognition, instrumental and basic activities of daily living collected by a trained psychologist, and a systematic detection of incident cases of dementia. The participation rate of each follow-up screening was around 75%. The detection of dementia was conducted with a two-stage design, with a first stage conducted by the psychologist and the confirmation of the diagnosis made at home by a physician, specialist in Alzheimer disease and related disorders (ADRD). Over 20 years of follow-up more than 800 subjects developed incident dementia and more than 2.500 died. Paquid remains the only representative cohort of elderly people living at home in France, giving estimations of prevalence, incidence and duration of ADRD and dependency. Thirty six risk factors of dementia and/or AD have been studied. On the basis of the Paquid data, we have shown that the prodromal phase of AD was longer than ten years and that dementia represented the major cause of dependency in the elderly.
authors.affiliation: Unité Inserm 897, Université Bordeaux Ségalen, Bordeaux, CMRR Bordeaux, CHU de Bordeaux, Bordeaux.
authors.forename: Jean-François
authors.initials: JF
authors.lastname: Dartigues
authors.forename: Catherine
authors.initials: C
authors.lastname: Helmer
authors.forename: Luc
authors.initials: L
authors.lastname: Letenneur
authors.forename: Karine
authors.initials: K
authors.lastname: Péres
authors.forename: Hélène
authors.initials: H
authors.lastname: Amieva
authors.forename: Sophie
authors.initials: S
authors.lastname: Auriacombe
authors.forename: Jean-Marc
authors.initials: JM
authors.lastname: Orgogozo
authors.forename: Daniel
authors.initials: D
authors.lastname: Commenges
authors.forename: Hélène
authors.initials: H
authors.lastname: Jacqmin-Gadda
authors.forename: Sandrine
authors.initials: S
authors.lastname: Richard-Harston
authors.forename: Fleur
authors.initials: F
authors.lastname: Delva
authors.forename: Alexandra
authors.initials: A
authors.lastname: Foubert-Samier
authors.forename: Pascale
authors.initials: P
authors.lastname: Barberger-Gateau
mesh_terms: D000203:Activities of Daily Living / Q000145:classification*; D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000175:diagnosis* / Q000453:epidemiology* / Q000523:psychology; D017028:Caregivers / Q000523:psychology; D015331:Cohort Studies; D003299:Cooperative Behavior; D017281:Cost of Illness; D005260:Female; D005500:Follow-Up Studies; D016330:Frail Elderly; D005602:France; D006801:Humans; D057187:Independent Living / Q000145:classification / Q000523:psychology; D033183:Interdisciplinary Communication; D008297:Male; D008403:Mass Screening / Q000523:psychology; D062706:Prodromal Symptoms; D011897:Random Allocation