title: Phenotypic assessment of male fertility status in transgenic animal models.
abstract: This chapter describes the approach to define the cause of male infertility in a genetically modified male mouse. It provides a guide to the establishment of the infertility status and whether it is due to the failure of mating or due to abnormalities of the sperm output, motility, and morphology. Further assessments define the nature of the spermatogenic defects and their severity and are designed to determine the pathogenic mechanisms involved.
authors.affiliation: Department of Anatomy and Developmental Biology, Monash Institute of Medical Research, Monash University, Clayton, Melbourne, VIC, Australia. david.dekretser@govhouse.vic.gov.au
authors.forename: David M
authors.initials: DM
authors.lastname: de Kretser
authors.forename: Liza
authors.initials: L
authors.lastname: O'Donnell
mesh_terms: D000818:Animals; D005298:Fertility / Q000502:physiology*; D008297:Male; D051379:Mice; D008822:Mice, Transgenic; D008853:Microscopy / Q000379:methods; D008854:Microscopy, Electron / Q000379:methods; D010641:Phenotype; D013076:Sperm Count; D013081:Sperm Motility; D013091:Spermatogenesis / Q000502:physiology; D013094:Spermatozoa / Q000502:physiology; D013737:Testis / Q000166:cytology / Q000648:ultrastructure