title: MMP-2 and sTNF-R1 Variability in Patients with Essential Hypertension: 1-Year Follow-Up Study.
abstract: The aim of this study is to analyze MMP-2 and sTNF-R1 variability, potent predictors of cardiovascular events, in stable hypertensive patients during a 12-month followup. 234 asymptomatic patients (age 60 ± 13, 136 male) out of 252 patients with essential hypertension were followed up. MMP-2 and sTNF-R1 were measured at baseline and after 12 months (stage I). To compare MMP-2 and sTNF-R1 levels over time interval, we used the statistical method of Bland-Altman. MMP-2 and sTNF-R1 reproducibility was good in our patients for the two intervals with a coefficient of reproducibility of 8.2% and 11.3%, respectively. The percentages of patients within 1.96 × standard deviation of the mean were 93.6% and 92.7%. An elevated coefficient of correlation was obtained for MMP-2, basal versus stage I (r = 0.55, P < 0.0001) and for sTNF-R1 (r = 0.75, P < 0.0001). There is good stability in MMP-2 and sTNF-R1 levels in a followup study of patients with stable hypertension. As a consequence, assessment of its concentrations may be a useful tool for monitoring the follow-up of these patients. Measured variations in MMP-2 and sTNF-R1 levels, exceeding 8.2% and 11.3%, respectively, may indicate an increase in cardiovascular risk, thus, could be used to optimizing treatment than blood pressure control alone.
authors.affiliation: Cardiocirculatory Unit, Research Center, Hospital Universitario y Politécnico La Fe, 46009 Valencia, Spain.
authors.forename: Núria
authors.initials: N
authors.lastname: Carpena
authors.forename: Esther
authors.initials: E
authors.lastname: Roselló-Lletí
authors.forename: Jose R
authors.initials: JR
authors.lastname: Calabuig
authors.forename: Estefanía
authors.initials: E
authors.lastname: Tarazón
authors.forename: Jose R
authors.initials: JR
authors.lastname: González-Juanatey
authors.forename: Luis
authors.initials: L
authors.lastname: Martínez-Dolz
authors.forename: Antonio
authors.initials: A
authors.lastname: Salvador
authors.forename: Lilian
authors.initials: L
authors.lastname: Grigorian
authors.forename: Plácido
authors.initials: P
authors.lastname: Orosa
authors.forename: Manuel
authors.initials: M
authors.lastname: Portolés
authors.forename: Miguel
authors.initials: M
authors.lastname: Rivera