title: [The potential nephrotoxicity of antiretroviral drugs].
abstract: The intensive studies carried out in many scientific laboratories and the efforts of numerous pharmaceutical companies have led to the development of drugs which are able to effectively inhibit HIV proliferation. At present, a number of antiretroviral agents with different mechanisms of action are available. Unfortunately, long-term use of antiretroviral drugs, however, does not remain indifferent to the patient and can cause significant side effects.    In the present work, the antiretroviral drugs with a nephrotoxicity potential most commonly used in clinical practice are described. In the review attention has also been focused on the nephropathy resulting from the HIV infection alone and the influence of genetic factors on the occurrence of pathological changes in the kidney.
authors.affiliation: Pracownia Markerów Nefrotoksyczności Środowiskowej, Katedra i Zakład Toksykologii Uniwersytetu Medycznego im. Piastów Śląskich we Wrocławiu, ul. Borowska 211, 50-556 Wrocław, Poland. zofia.marchewka@am.wroc.pl
authors.forename: Zofia
authors.initials: Z
authors.lastname: Marchewka
authors.forename: Beata
authors.initials: B
authors.lastname: Szymańska
authors.forename: Joanna
authors.initials: J
authors.lastname: Płonka
mesh_terms: D000818:Animals; D044966:Anti-Retroviral Agents / Q000009:adverse effects*; D015658:HIV Infections / Q000150:complications / Q000188:drug therapy; D006801:Humans; D007674:Kidney Diseases / Q000139:chemically induced* / Q000235:genetics / Q000517:prevention & control
chemical_list: D044966:Anti-Retroviral Agents