title: Extremity trauma, dressings, and wound infection: should every acute limb wound have a silver lining?
abstract: The manner in which high-energy transfer limb injuries are dressed can alter the wound environment through manipulation of the bacterial burden, thus minimizing tissue degradation and influencing healing potential. Infection is the principal complication of such wounds, and antiseptic soaked gauze is accepted in early coverage of extremity wounds despite a lack of evidence to support this practice. There has been resurgence in the use of silver in acute wounds, through dressings manipulated to deliver sustained elemental silver to the wound interface. In vitro and in vivo experimentation of silver dressings are characterized however by methodological compromise, primarily through lack of similarity of models to the physiology of the healing wound. Results from in vitro studies caution against the use of silver because of evidence of cytotoxicity, but this is not reproduced in in vivo or clinical experimentation, leading to ambiguity. Review of silver dressing application in burns and chronic wound studies fails to support its use over other dressing systems. Similarly, evidence for the use of silver in acute limb wounds is lacking. This article provides a comprehensive overview of the use of silver dressings in acute wound care and highlights in particular the paucity of evidence regarding its routine use in extremity injury.
authors.affiliation: Royal Centre for Defence Medicine, Birmingham, UK. willeardley@doctors.org.uk
authors.forename: William G P
authors.initials: WG
authors.lastname: Eardley
authors.forename: Sarah A
authors.initials: SA
authors.lastname: Watts
authors.forename: Jon C
authors.initials: JC
authors.lastname: Clasper
mesh_terms: D000208:Acute Disease; D000890:Anti-Infective Agents / Q000627:therapeutic use; D001458:Bandages; D005121:Extremities / Q000293:injuries / Q000294:innervation* / Q000473:pathology; D006801:Humans; D036103:Nanotechnology; D018030:Silver Compounds / Q000627:therapeutic use*; D014945:Wound Healing; D014946:Wound Infection / Q000188:drug therapy*; D014947:Wounds and Injuries
chemical_list: D000890:Anti-Infective Agents; D018030:Silver Compounds