title: Carotid intima-media thickness and laboratory parameters of atherosclerosis risk in patients with breast cancer.
abstract: OBJECTIVE
  To investigate the relation between intima-media thickness (IMT) and laboratory parameters of atherosclerosis risk in patients with breast carcinoma.
  
  
  METHODS
  IMT and a panel of laboratory parameters associated with the risk of atherosclerosis were studied in 192 patients with histologically-verified breast carcinoma.
  
  
  RESULTS
  Patients with metastatic disease had significantly higher fibrinogen, C-reactive protein (CRP), urinary neopterin and mean IMT, and significantly lower serum albumin and hemoglobin concentrations. Significant correlations were observed between CRP, urinary neopterin, mean IMT and other parameters of cardiovascular risk. Age was an independent predictor of the presence of sonographic signs of atherosclerosis using logistic regression, and age, glucose, time from start of chemotherapy, high-density lipoprotein cholesterol, D-dimers were independently associated with IMT in stepwise regression models.
  
  
  CONCLUSIONS
  In addition to the associations between IMT and laboratory or clinical parameters of the risk of atherosclerosis, IMT may also be associated with the time from chemotherapy.
authors.affiliation: Department of Oncology, Palacký University Medical School and Teaching Hospital, Olomouc, Czech Republic. bohuslav.melichar@fnol.cz
authors.forename: Bohuslav
authors.initials: B
authors.lastname: Melichar
authors.forename: Hana
authors.initials: H
authors.lastname: Kalábová
authors.forename: Leoš
authors.initials: L
authors.lastname: Ungermann
authors.forename: Lenka
authors.initials: L
authors.lastname: Krčmová
authors.forename: Radomír
authors.initials: R
authors.lastname: Hyšpler
authors.forename: Markéta
authors.initials: M
authors.lastname: Kašparová
authors.forename: Miroslav
authors.initials: M
authors.lastname: Pecka
authors.forename: Vlastislav
authors.initials: V
authors.lastname: Šrámek
authors.forename: Hana
authors.initials: H
authors.lastname: Procházková-Študentová
authors.forename: Adam
authors.initials: A
authors.lastname: Svobodník
authors.forename: Ladislav
authors.initials: L
authors.lastname: Pecen
authors.forename: Dagmar
authors.initials: D
authors.lastname: Solichová
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D050197:Atherosclerosis / Q000000981:diagnostic imaging* / Q000378:metabolism / Q000473:pathology; D001943:Breast Neoplasms / Q000000981:diagnostic imaging* / Q000378:metabolism / Q000473:pathology; D002097:C-Reactive Protein / Q000378:metabolism; D059168:Carotid Intima-Media Thickness; D005260:Female; D005340:Fibrinogen / Q000378:metabolism; D006801:Humans; D016015:Logistic Models; D008875:Middle Aged; D019798:Neopterin / Q000652:urine; D012307:Risk Factors; D017540:Tunica Media / Q000000981:diagnostic imaging / Q000473:pathology
chemical_list: D019798:Neopterin; D005340:Fibrinogen; D002097:C-Reactive Protein