title: Associations between white matter microstructure and infants' working memory.
abstract: Working memory emerges in infancy and plays a privileged role in subsequent adaptive cognitive development. The neural networks important for the development of working memory during infancy remain unknown. We used diffusion tensor imaging (DTI) and deterministic fiber tracking to characterize the microstructure of white matter fiber bundles hypothesized to support working memory in 12-month-old infants (n=73). Here we show robust associations between infants' visuospatial working memory performance and microstructural characteristics of widespread white matter. Significant associations were found for white matter tracts that connect brain regions known to support working memory in older children and adults (genu, anterior and superior thalamic radiations, anterior cingulum, arcuate fasciculus, and the temporal-parietal segment). Better working memory scores were associated with higher FA and lower RD values in these selected white matter tracts. These tract-specific brain-behavior relationships accounted for a significant amount of individual variation above and beyond infants' gestational age and developmental level, as measured with the Mullen Scales of Early Learning. Working memory was not associated with global measures of brain volume, as expected, and few associations were found between working memory and control white matter tracts. To our knowledge, this study is among the first demonstrations of brain-behavior associations in infants using quantitative tractography. The ability to characterize subtle individual differences in infant brain development associated with complex cognitive functions holds promise for improving our understanding of normative development, biomarkers of risk, experience-dependent learning and neuro-cognitive periods of developmental plasticity.
authors.affiliation: Department of Psychiatry, University of North Carolina, Chapel Hill, NC 27599, USA. sjshort@med.unc.edu
authors.forename: Sarah J
authors.initials: SJ
authors.lastname: Short
authors.forename: Jed T
authors.initials: JT
authors.lastname: Elison
authors.forename: Barbara Davis
authors.initials: BD
authors.lastname: Goldman
authors.forename: Martin
authors.initials: M
authors.lastname: Styner
authors.forename: Hongbin
authors.initials: H
authors.lastname: Gu
authors.forename: Mark
authors.initials: M
authors.lastname: Connelly
authors.forename: Eric
authors.initials: E
authors.lastname: Maltbie
authors.forename: Sandra
authors.initials: S
authors.lastname: Woolson
authors.forename: Weili
authors.initials: W
authors.lastname: Lin
authors.forename: Guido
authors.initials: G
authors.lastname: Gerig
authors.forename: J Steven
authors.initials: JS
authors.lastname: Reznick
authors.forename: John H
authors.initials: JH
authors.lastname: Gilmore
mesh_terms: D001921:Brain / Q000033:anatomy & histology* / Q000502:physiology*; D003071:Cognition / Q000502:physiology*; D005260:Female; D006801:Humans; D007223:Infant; D008279:Magnetic Resonance Imaging; D008297:Male; D008570:Memory, Short-Term / Q000502:physiology*; D009413:Nerve Fibers, Myelinated / Q000502:physiology* / Q000648:ultrastructure*; D013223:Statistics as Topic