title: [Caveolin-1: a novel biomarker for prostate cancer].
abstract: For lack of the biomarker, early diagnosis of prostate cancer is often difficult. Caveolin-1 (Cav-1) is an important oncogene and a major structural coat protein of caveolae, which is involved in multiple cellular functions including molecular transport, cell adhesion, and signal transduction, as well as in the development and progression of prostate cancer. Cav-1 is secreted as a biologically active molecule that promotes cell survival and angiogenesis within the tumor microenvironment, and is overexpressed in the metastatic and primary sites of human prostate cancer. Secreted Cav-1 can be detected in the peripheral blood, and its expression level has an indicative value in the diagnosis and prognosis of prostate cancer. This review focuses on the structure and biological characteristics of Cav-1 and its correlation with prostate cancer.
authors.affiliation: Department of Oncology, Wuxi Peoples Hospital Affiliated to Nanjing Medical University, Wuxi, Jiangsu 214023, China.
authors.forename: Wei-Sun
authors.initials: WS
authors.lastname: Huang
authors.forename: Run-Jie
authors.initials: RJ
authors.lastname: Wang
authors.forename: Jun-Li
authors.initials: JL
authors.lastname: Ding
authors.forename: Chao-Ying
authors.initials: CY
authors.lastname: Liu
authors.forename: Jing-Hua
authors.initials: JH
authors.lastname: Wang
mesh_terms: D014408:Biomarkers, Tumor; D051242:Caveolin 1; D006801:Humans; D008297:Male; D011471:Prostatic Neoplasms / Q000175:diagnosis
chemical_list: D014408:Biomarkers, Tumor; C495540:CAV1 protein, human; D051242:Caveolin 1