title: Safety and effectiveness of maxillary early loaded titanium implants with a novel nanostructured calcium-incorporated surface (Xpeed): 1-year results from a pilot multicenter randomised controlled trial.
abstract: OBJECTIVE
  To evaluate clinical safety and effectiveness of a novel calcium-incorporated titanium implant (Xpeed, MegaGen Implant Co. Limited, Gyeongbuk, South Korea).
  
  
  METHODS
  Sixty patients were randomised to receive either 1 to 6 calcium-incorporated or control titanium implants in the maxilla according to a parallel group design at 2 different centres. Implants were submerged and exposed at 3 different endpoints in equal groups of 20 patients each at 12, 10 and 8 weeks, respectively. Within 2 weeks, implants were functionally loaded with provisional or definitive prostheses. Outcome measures were prosthesis failures, implant failures, any complications and peri-implant marginal bone level changes.
  
  
  RESULTS
  Thirty patients received 45 calcium-incorporated implants and 30 patients received 42 control titanium implants. One year after loading, no drop-outs and no prosthesis or implant failures occurred. There were no statistically significant differences between groups for complications (P = 0.61; difference in proportions = -0.27; 95% CI -0.71 to 0.18) and mean marginal bone level changes (P = 0.64; mean difference -0.04 mm; 95% CI -0.22 to 0.13).
  
  
  CONCLUSIONS
  Nanostructured calcium-incorporated titanium implants seem to be at least as effective and safe as conventional titanium implants.
authors.affiliation: Deparment of Biomaterials, the Sahlgrenska Academy at Götenburg University, Sweden. espositomarco@hotmail.com
authors.forename: Marco
authors.initials: M
authors.lastname: Esposito
authors.forename: Maria Gabriella
authors.initials: MG
authors.lastname: Grusovin
authors.forename: Gerardo
authors.initials: G
authors.lastname: Pellegrino
authors.forename: Elisa
authors.initials: E
authors.lastname: Soardi
authors.forename: Pietro
authors.initials: P
authors.lastname: Felice
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D016301:Alveolar Bone Loss / Q000209:etiology; D000539:Alveolar Process / Q000473:pathology; D001672:Biocompatible Materials / Q000737:chemistry*; D002130:Calcium Phosphates / Q000737:chemistry*; D059605:Dental Implant-Abutment Design; D003758:Dental Implantation, Endosseous / Q000379:methods; D015921:Dental Implants; D003764:Dental Materials / Q000737:chemistry*; D017267:Dental Prosthesis Design; D019094:Dental Prosthesis, Implant-Supported; D019232:Dental Restoration Failure; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008437:Maxilla / Q000601:surgery*; D008875:Middle Aged; D049329:Nanostructures / Q000737:chemistry*; D016348:Osseointegration / Q000502:physiology; D010865:Pilot Projects; D012449:Safety; D013499:Surface Properties; D014025:Titanium / Q000737:chemistry*; D016896:Treatment Outcome
chemical_list: D001672:Biocompatible Materials; D002130:Calcium Phosphates; D015921:Dental Implants; D003764:Dental Materials; C020243:calcium phosphate; D014025:Titanium