title: Shift in the timing of respiratory syncytial virus circulation in a subtropical megalopolis: implications for immunoprophylaxis.
abstract: Respiratory syncytial virus (RSV) is the most common cause of severe respiratory infections worldwide, and an important cause of childhood bronchiolitis, pneumonia, and mortality. Although prevention of RSV infection by immunoprophylaxis with palivizumab has proved effective, a precise understanding of the timing of RSV outbreaks is necessary to ensure that infants are protected when RSV is circulating. In this study a consistent shift in the seasonal patterns of RSV circulation in southeast Brazil (São Paulo) is reported based on the analysis of 15 years of viral surveillance. Surveillance was conducted from 1996 to 2010 and involved the collection of samples from children with symptoms of acute respiratory infection. Putative changes in school terms, in the proportion of RSV genotypes infecting children and in the seasonal dynamics of several climatic parameters during the period were also investigated. The results revealed a progression in the timing of RSV seasons, with a shift in the onset and peak of RSV epidemics from 2007 onwards. Although lower rainfall and temperatures were associated with the onset of outbreaks, there was no evidence of changes in climate, school terms or in the relative proportion of genotypes in the period analyzed. These findings have direct implications for improving the prophylactic use of palivizumab, and stress the importance of fine tuning prophylaxis with recent surveillance data. In the case of São Paulo, palivizumab prophylaxis should be initiated earlier than suggested currently. Similar adjustments may be necessary in other regions.
authors.affiliation: Center of Respiratory Diseases, Adolfo Lutz Institute, São Paulo, Brazil.
authors.forename: Terezinha M
authors.initials: TM
authors.lastname: Paiva
authors.forename: Maria A
authors.initials: MA
authors.lastname: Ishida
authors.forename: Margarete A
authors.initials: MA
authors.lastname: Benega
authors.forename: Clóvis R A
authors.initials: CR
authors.lastname: Constantino
authors.forename: Daniela B B
authors.initials: DB
authors.lastname: Silva
authors.forename: Kátia C O
authors.initials: KC
authors.lastname: Santos
authors.forename: Maria I
authors.initials: MI
authors.lastname: Oliveira
authors.forename: Helena A
authors.initials: HA
authors.lastname: Barbosa
authors.forename: Telma R M P
authors.initials: TR
authors.lastname: Carvalhanas
authors.forename: Cynthia
authors.initials: C
authors.lastname: Schuck-Paim
authors.forename: Wladimir J
authors.initials: WJ
authors.lastname: Alonso
mesh_terms: D001938:Brazil / Q000453:epidemiology; D002675:Child, Preschool; D006801:Humans; D015994:Incidence; D007223:Infant; D018357:Respiratory Syncytial Virus Infections / Q000453:epidemiology*; D018113:Respiratory Syncytial Virus, Human / Q000302:isolation & purification*; D012621:Seasons; D018571:Sentinel Surveillance; D013696:Temperature; D014887:Weather