title: Relationships of uPA and VEGF expression in esophageal cancer and microvascular density with tumorous invasion and metastasis.
abstract: OBJECTIVE
  To investigate uPA and VEGF expression in esophageal cancer and relations with tumorous invasion and metastasis.
  
  
  METHODS
  Immunohistochemistry was used to detect uPA and VEGF expression in the normal epithelial tissue of esophageal mucosa and cancer tissue and detect CD34 labeled micrangium and analyze the relationships with clinical pathological features and tumor angiogenesis.
  
  
  RESULTS
  Positive rates for uPA and VEGF protein expression were significantly greater in esophageal cancer than normal epithelial tissue (P < 0.05), the two being linked (P <0.05). In addition, uPA and VEGF protein expression of the high microvessel density (MVD) group was significantly lower than in the low MVD group (P < 0.05), with relation to clinical pathological staging, differentiation and lymph node metastasis (P < 0.05).
  
  
  CONCLUSIONS
  In esophageal cancer tissue, uPA and VEGF proteins are overexpressed and promote tumor angiogenesis, indicative of a poor prognosis.
authors.affiliation: Department of Thoracic Surgery, the Second Affiliated Hospital of Medical College of XI'an Jiaotong University, Xi'an, China.
authors.forename: Jian-Tao
authors.initials: JT
authors.lastname: Jiang
authors.forename: Lan-Fang
authors.initials: LF
authors.lastname: Zhang
authors.forename: Bin
authors.initials: B
authors.lastname: Zhou
authors.forename: Shun-Qun
authors.initials: SQ
authors.lastname: Zhang
authors.forename: Shao-Min
authors.initials: SM
authors.lastname: Li
authors.forename: Wei
authors.initials: W
authors.lastname: Zhang
authors.forename: Jin
authors.initials: J
authors.lastname: Zhang
authors.forename: Zhe
authors.initials: Z
authors.lastname: Qiao
authors.forename: Ran-Ran
authors.initials: RR
authors.lastname: Kong
authors.forename: Yue-Feng
authors.initials: YF
authors.lastname: Ma
authors.forename: Sheng
authors.initials: S
authors.lastname: Chen
mesh_terms: D004938:Esophageal Neoplasms / Q000098:blood supply* / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D005260:Female; D006801:Humans; D007150:Immunohistochemistry / Q000379:methods; D008198:Lymph Nodes / Q000378:metabolism / Q000473:pathology; D008207:Lymphatic Metastasis; D008297:Male; D055806:Microvessels / Q000378:metabolism / Q000473:pathology; D008875:Middle Aged; D009092:Mucous Membrane / Q000378:metabolism / Q000473:pathology; D009361:Neoplasm Invasiveness; D009389:Neovascularization, Pathologic / Q000235:genetics / Q000378:metabolism / Q000473:pathology; D011379:Prognosis; D014568:Urokinase-Type Plasminogen Activator / Q000096:biosynthesis* / Q000235:genetics / Q000378:metabolism; D042461:Vascular Endothelial Growth Factor A / Q000096:biosynthesis* / Q000235:genetics / Q000378:metabolism
chemical_list: C467484:VEGFA protein, human; D042461:Vascular Endothelial Growth Factor A; D014568:Urokinase-Type Plasminogen Activator