title: A case of infantile de novo primary antiphospholipid syndrome revealed by a neonatal arterial ischemic stroke.
abstract: The few cases of antiphospholipid syndrome that have been reported in neonates are believed to have resulted from a transplacental transfer of antiphospholipid antibodies. Here we report on a boy with a neonatal stroke revealing a de novo primary antiphospholipid, the mother being free of antiphospholipid antibodies. Other thrombosis risk factors included primiparity, gestational diabetes, macrosomia, polyglobulia, and lipoprotein(a) >30 mg/dL. Anti-cardiolipin and anti-β(2)-glycoprotein I persisted more than 2 years. Under aspirin therapy, the child did not exhibit recurrence of thrombotic events or symptoms of autoimmunity after a follow-up of 3 years. Our case indicates that clinicians should consider a second retesting for anticardiolipin antibodies and anti-β(2)-glycoprotein I antibodies, even when children and mother neonatal tests are negative.
authors.affiliation: CHU Clermont-Ferrand, Clermont-Ferrand, France.
authors.forename: Etienne
authors.initials: E
authors.lastname: Merlin
authors.forename: Eric
authors.initials: E
authors.lastname: Doré
authors.forename: Stéphane
authors.initials: S
authors.lastname: Chabrier
authors.forename: Marie
authors.initials: M
authors.lastname: Biard
authors.forename: Alain
authors.initials: A
authors.lastname: Marques-Verdier
authors.forename: Jean-Louis
authors.initials: JL
authors.lastname: Stéphan
mesh_terms: D000328:Adult; D017152:Antibodies, Antiphospholipid / Q000097:blood; D016736:Antiphospholipid Syndrome / Q000097:blood / Q000150:complications* / Q000276:immunology*; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D020521:Stroke / Q000209:etiology* / Q000276:immunology
chemical_list: D017152:Antibodies, Antiphospholipid