title: [Adverse events associated with long-term use of proton pump inhibitors].
abstract: Proton pump inhibitors (PPI) remain the leading therapy for acid-related disorders. Long-term PPI use increases the risk of pneumonia and enteric bacterial infections and of nosocomial Clostridium difficile-associated diarrhoea. PPIs do not lead to vitamin B12 or iron deficiencies and do not induce malignancies or increase the risk of major birth defects. Prolonged PPI use may be a weak risk factor for certain fractures and results in hypergastrinaemia and parietal cell hyperplasia leading to rebound acid hypersecretion, which may induce symptoms on withdrawal of therapy.
authors.affiliation: Medicinsk Afdeling, Køge Sygehus, Lykkebækvej 1, Køge.
authors.forename: Christina
authors.initials: C
authors.lastname: Reimer
authors.forename: Peter
authors.initials: P
authors.lastname: Bytzer
mesh_terms: D000897:Anti-Ulcer Agents / Q000008:administration & dosage / Q000009:adverse effects*; D001424:Bacterial Infections / Q000139:chemically induced; D000013:Congenital Abnormalities / Q000209:etiology; D004415:Dyspepsia / Q000139:chemically induced; D050723:Fractures, Bone / Q000139:chemically induced; D005755:Gastrins / Q000378:metabolism; D005759:Gastroenteritis / Q000139:chemically induced; D005764:Gastroesophageal Reflux / Q000139:chemically induced; D006356:Heartburn / Q000139:chemically induced; D006801:Humans; D009369:Neoplasms / Q000139:chemically induced; D009853:Omeprazole / Q000008:administration & dosage / Q000009:adverse effects; D011014:Pneumonia / Q000139:chemically induced; D054328:Proton Pump Inhibitors / Q000008:administration & dosage / Q000009:adverse effects*; D012307:Risk Factors; D013997:Time Factors; D014806:Vitamin B 12 Deficiency / Q000139:chemically induced
chemical_list: D000897:Anti-Ulcer Agents; D005755:Gastrins; D054328:Proton Pump Inhibitors; D009853:Omeprazole