title: Initial experience with Penumbra Coil 400 versus standard coils in embolization of cerebral aneurysms: a retrospective review.
abstract: OBJECTIVE
  The Penumbra Coil 400 System (PC 400) is the newly introduced platinum coil system designed specifically to enhance filling efficiency by increasing coil diameter. Our goal was to study the packing and treatment advantage of the PC 400's unique geometric configuration compared with conventional coils (controls).
  
  
  METHODS
  16 aneurysms embolized with the PC 400 in 2011 were compared with 79 equally matched aneurysms embolized with conventional coils from 2004 to 2011. Primary outcomes assessed were acute packing density, embolization time, and the number of coils required for aneurysm occlusion.
  
  
  RESULTS
  Aneurysm embolization with the PC 400 achieved a higher packing density (36.8% vs 28.1%; p<0.005) and with fewer coils (an average of 3.9 vs 6.1 coils per aneurysm; p<0.05). In addition, the total procedural time for the subjects treated with the PC 400 was significantly less (45.7 vs 64.1 min; p<0.05). There were no procedural complications associated with the PC 400.
  
  
  CONCLUSIONS
  Compared with conventional coils, the PC 400 is more efficient in the embolization of cerebral aneurysms, achieving greater packing density with fewer coils and less time without compromising safety.
authors.affiliation: Department of Neurosurgery, Mount Sinai School of Medicine, New York, New York, USA.
authors.forename: Justin R
authors.initials: JR
authors.lastname: Mascitelli
authors.forename: Maritsa F
authors.initials: MF
authors.lastname: Polykarpou
authors.forename: Aanand A
authors.initials: AA
authors.lastname: Patel
authors.forename: Ashwin A
authors.initials: AA
authors.lastname: Kamath
authors.forename: Henry
authors.initials: H
authors.lastname: Moyle
authors.forename: Aman B
authors.initials: AB
authors.lastname: Patel
mesh_terms: D002533:Cerebral Angiography; D020099:Coated Materials, Biocompatible; D004621:Embolization, Therapeutic / Q000009:adverse effects / Q000295:instrumentation* / Q000379:methods; D004867:Equipment Design; D005260:Female; D006801:Humans; D002532:Intracranial Aneurysm / Q000628:therapy*; D008297:Male; D055595:Mechanical Phenomena; D008875:Middle Aged; D010984:Platinum; D012189:Retrospective Studies; D015607:Stents / Q000009:adverse effects; D013927:Thrombosis / Q000209:etiology; D016896:Treatment Outcome
chemical_list: D020099:Coated Materials, Biocompatible; D010984:Platinum