title: Total synthesis of debromoflustramines B and E based on the intramolecular carbamoylketene-alkene [2 + 2] cycloaddition.
abstract: Total synthesis of debromoflustramines B and E has been accomplished by using a platinum-catalyzed addition reaction of o-aminophenylboronic acid with the allene and an intramolecular carbamoylketene-alkene [2 + 2] cycloaddition for the construction of the basic carbon framework of the target alkaloids as the key steps.
authors.affiliation: Graduate School of Pharmaceutical Sciences, The University of Tokushima, 1-78-1 Sho-machi, Tokushima 770-8505, Japan.
authors.forename: Tsukasa
authors.initials: T
authors.lastname: Ozawa
authors.forename: Makoto
authors.initials: M
authors.lastname: Kanematsu
authors.forename: Hiromasa
authors.initials: H
authors.lastname: Yokoe
authors.forename: Masahiro
authors.initials: M
authors.lastname: Yoshida
authors.forename: Kozo
authors.initials: K
authors.lastname: Shishido
mesh_terms: D000470:Alkaloids / Q000138:chemical synthesis* / Q000737:chemistry; D000475:Alkenes / Q000737:chemistry*; D003500:Cyclization; D026121:Indole Alkaloids / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D013237:Stereoisomerism
chemical_list: C579030:1-methyl-3a-(3-methylbut-2-enyl)-1,2,3,3a,8,8a-hexahydropyrrolo(2,3-b)indole; D000470:Alkaloids; D000475:Alkenes; D026121:Indole Alkaloids; C090331:debromoflustramine B