title: Microbial biotransformation of kurarinone by Cunninghamella echinulata AS 3.3400.
abstract: In this paper, microbial transformation of kurarinone (1) by Cunninghamella echinulata AS 3.3400 was investigated and four transformed products were isolated and identified as 6″-hydroxykurarinone (2), 4″,5″,8″-trihydroxynorkurarinone (3), norkurarinone (4), and kurarinone-7-O-β-glucoside (5), respectively. Among them, 3 and 5 are new compounds, and the rare glycosylation in microbial transformation was observed. In addition, the cytotoxicities of transformed products (2-5) were also investigated.
authors.affiliation: State Key Laboratory of Chemical Resource Engineering, College of Life Science and Technology, Beijing University of Chemical Technology, Beijing, 100029, China.
authors.forename: Yan-Qiu
authors.initials: YQ
authors.lastname: Shi
authors.forename: Xiu-Lan
authors.initials: XL
authors.lastname: Xin
authors.forename: Qi-Peng
authors.initials: QP
authors.lastname: Yuan
authors.forename: Chang-Yuan
authors.initials: CY
authors.lastname: Wang
authors.forename: Bao-Jing
authors.initials: BJ
authors.lastname: Zhang
authors.forename: Jie
authors.initials: J
authors.lastname: Hou
authors.forename: Yan
authors.initials: Y
authors.lastname: Tian
authors.forename: Sa
authors.initials: S
authors.lastname: Deng
authors.forename: Shan-Shan
authors.initials: SS
authors.lastname: Huang
authors.forename: Xiao-Chi
authors.initials: XC
authors.lastname: Ma
mesh_terms: D001711:Biotransformation; D020093:Cunninghamella / Q000378:metabolism*; D003603:Cytotoxins / Q000737:chemistry* / Q000494:pharmacology; D005419:Flavonoids / Q000737:chemistry* / Q000378:metabolism / Q000494:pharmacology; D005960:Glucosides / Q000737:chemistry / Q000378:metabolism; D015394:Molecular Structure
chemical_list: D003603:Cytotoxins; D005419:Flavonoids; D005960:Glucosides; C411319:kurarinone