title: Antifouling properties of poly(dimethylsiloxane) surfaces modified with quaternized poly(dimethylaminoethyl methacrylate).
abstract: A quaternized poly(dimethylaminoethyl methacrylate)-grafted poly(dimethylsiloxane) (PDMS) surface (PDMS-QPDMAEMA) was successfully prepared in this study via solution-phase oxidation reaction and surface-initiated atom transfer radical polymerization (SI-ATRP) using dimethylaminoethyl methacrylate (DMAEMA) as initial monomer. PDMS substrates were first oxidized in H(2)SO(4)/H(2)O(2) solution to transform the SiCH(3) groups on their surfaces into SiOH groups. Subsequently, a surface initiator for ATRP was immobilized onto the PDMS surface, and DMAEMA was then grafted onto the PDMS surface via copper-mediated ATRP. Finally, the tertiary amino groups of PolyDMAEMA (PDMAEMA) were quaternized by ethyl bromide to provide a cationic polymer brush-modified PDMS surface. Various characterization techniques, including contact angle measurements, attenuated total reflection infrared spectroscopy, and X-ray photoelectron spectroscopy, were used to ascertain the successful grafting of the quaternized PDMAEMA brush onto the PDMS surface. Furthermore, the wettability and stability of the PDMS-QPDMAEMA surface were examined by contact angle measurements. Antifouling properties were investigated via protein adsorption, as well as bacterial and cell adhesion studies. The results suggest that the PDMS-QPDMAEMA surface exhibited durable wettability and stability, as well as significant antifouling properties, compared with the native PDMS and PDMS-PDMAEMA surfaces. In addition, our results present possible uses for the PDMS-QPDMAEMA surface as adhesion barriers and antifouling or functional surfaces in PDMS microfluidics-based biomedical applications.
authors.affiliation: College of Science, Northwest A&F University, Yangling, Shaanxi 712100, PR China.
authors.forename: Qin
authors.initials: Q
authors.lastname: Tu
authors.forename: Jian-Chun
authors.initials: JC
authors.lastname: Wang
authors.forename: Rui
authors.initials: R
authors.lastname: Liu
authors.forename: Juan
authors.initials: J
authors.lastname: He
authors.forename: Yanrong
authors.initials: Y
authors.lastname: Zhang
authors.forename: Shaofei
authors.initials: S
authors.lastname: Shen
authors.forename: Juan
authors.initials: J
authors.lastname: Xu
authors.forename: Jianjun
authors.initials: J
authors.lastname: Liu
authors.forename: Mao-Sen
authors.initials: MS
authors.lastname: Yuan
authors.forename: Jinyi
authors.initials: J
authors.lastname: Wang
mesh_terms: D000818:Animals; D001422:Bacterial Adhesion / Q000187:drug effects; D002448:Cell Adhesion / Q000187:drug effects; D004129:Dimethylpolysiloxanes / Q000737:chemistry* / Q000494:pharmacology; D006367:HeLa Cells; D061307:Human Umbilical Vein Endothelial Cells / Q000166:cytology / Q000187:drug effects; D006801:Humans; D051379:Mice; D046210:Microfluidic Analytical Techniques; D018625:Microscopy, Atomic Force; D041681:NIH 3T3 Cells; D056951:Photoelectron Spectroscopy; D011108:Polymers / Q000737:chemistry*
chemical_list: D004129:Dimethylpolysiloxanes; D011108:Polymers