title: Assessment of ventricular electrophysiological characteristics at periinfarct zone of postmyocardial infarction in rabbits following stellate ganglion block.
abstract: Assessment of Ventricular Electrophysiological Characteristics.
  
  
  BACKGROUND
  The aim of this study was to investigate the characteristics of ventricular electrophysiology following stellate ganglion block (SGB) at periinfarct zone in rabbits with myocardial infarction (MI).
  
  
  RESULTS
  Sixty-four rabbits were randomly assigned to 2 groups: MI (n = 32), ligation of the anterior descending coronary and sham operation (SO) (n = 32), without coronary ligation. Both MI and SO groups were divided into 4 subgroups according to right or left SGB and corresponding control (n = 8, each). After 8 weeks, 90% of monophasic action potential duration (MAPD90) of epicardium, midmyocardium and endocardium, transmural dispersion of repolarization (TDR), effective refractory period (ERP), and ventricular fibrillation threshold (VFT) were measured at the infarct border zone (MI group) and corresponding zone (SO group) following SGB. For SGB, 0.5 mL of 0.25% bupivacaine was used. Compared with the corresponding control group, in both the MI and SO groups, left SGB (LSGB) prolonged the MAPD90 of the 3 layers, reduced TDR, and increased ERP and VFT (P < 0.05). However, right SGB (RSGB) shortened MAPD90, increased TDR, and reduced ERP and VFT (P < 0.05).
  
  
  CONCLUSIONS
  The results of this study demonstrate that LSGB can increase the electrophysiological stability of ventricular myocardium.
authors.affiliation: Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan, China.
authors.forename: Yongwei
authors.initials: Y
authors.lastname: Gu
authors.forename: Long
authors.initials: L
authors.lastname: Wang
authors.forename: Xi
authors.initials: X
authors.lastname: Wang
authors.forename: Yanhong
authors.initials: Y
authors.lastname: Tang
authors.forename: Feng
authors.initials: F
authors.lastname: Cao
authors.forename: Yongyou
authors.initials: Y
authors.lastname: Fang
mesh_terms: D000200:Action Potentials; D000779:Anesthetics, Local; D000818:Animals; D001145:Arrhythmias, Cardiac / Q000209:etiology / Q000503:physiopathology / Q000517:prevention & control*; D001340:Autonomic Nerve Block / Q000379:methods; D002045:Bupivacaine; D004195:Disease Models, Animal; D022062:Electrophysiologic Techniques, Cardiac; D004699:Endocardium / Q000473:pathology / Q000503:physiopathology; D005260:Female; D006352:Heart Ventricles / Q000294:innervation / Q000473:pathology / Q000503:physiopathology*; D008297:Male; D009203:Myocardial Infarction / Q000150:complications / Q000473:pathology / Q000503:physiopathology*; D009206:Myocardium / Q000473:pathology; D010496:Pericardium / Q000473:pathology / Q000503:physiopathology; D011817:Rabbits; D012032:Refractory Period, Electrophysiological; D013233:Stellate Ganglion / Q000503:physiopathology*; D013997:Time Factors; D016276:Ventricular Function
chemical_list: D000779:Anesthetics, Local; D002045:Bupivacaine