title: Influence of TiN coating on the biocompatibility of medical NiTi alloy.
abstract: The biocompatibility of TiN coated nickel-titanium shape memory alloy (NiTi-SMA) was evaluated to compare with that of the uncoated NiTi-SMA. Based on the orthodontic clinical application, the surface properties and biocompatibility were characterized by scanning electron microscopy (SEM), X-ray diffraction (XRD), wettability test, mechanical test and in vitro tests including MTT, cell apoptosis and cell adhesion tests. It was observed that the bonding between the substrate and TiN coating is excellent. The roughness and wettability increased as for the TiN coating compared with the uncoated NiTi-SMA. MTT test showed no significant difference between the coated and uncoated NiTi-SMA, however the percentage of early cell apoptosis was significantly higher as for the uncoated NiTi alloy. SEM results showed that TiN coating could enhance the cell attachment, spreading and proliferation on NiTi-SMA. The results indicated that TiN coating bonded with the substrate well and could lead to a better biocompatibility.
authors.affiliation: School of Stomatology, China Medical University, Shenyang 110002, China.
authors.forename: Shi
authors.initials: S
authors.lastname: Jin
authors.forename: Yang
authors.initials: Y
authors.lastname: Zhang
authors.forename: Qiang
authors.initials: Q
authors.lastname: Wang
authors.forename: Dan
authors.initials: D
authors.lastname: Zhang
authors.forename: Song
authors.initials: S
authors.lastname: Zhang
mesh_terms: D000818:Animals; D017209:Apoptosis / Q000187:drug effects; D002448:Cell Adhesion; D002460:Cell Line; D049109:Cell Proliferation; D002470:Cell Survival; D020099:Coated Materials, Biocompatible / Q000737:chemistry*; D004396:Coloring Agents; D005434:Flow Cytometry; D008422:Materials Testing; D055595:Mechanical Phenomena; D051379:Mice; D008855:Microscopy, Electron, Scanning; D009532:Nickel / Q000737:chemistry*; D013499:Surface Properties; D013778:Tetrazolium Salts; D013844:Thiazoles; D014025:Titanium / Q000737:chemistry*; D014961:X-Ray Diffraction
chemical_list: D020099:Coated Materials, Biocompatible; D004396:Coloring Agents; D013778:Tetrazolium Salts; D013844:Thiazoles; C040654:titanium nickelide; C041500:titanium nitride; D009532:Nickel; D014025:Titanium; C022616:thiazolyl blue