title: Antimicrobial hydantoin-grafted poly(ε-caprolactone) by ring-opening polymerization and click chemistry.
abstract: Novel degradable and antibacterial polycaprolactone-based polymers are reported in this work. The polyesters with pendent propargyl groups are successfully prepared by ring-opening polymerization and subsequently used to graft antibacterial hydantoin moieties via click chemistry by a copper(I)-catalyzed azide-alkyne cycloaddition reaction. The well-controlled chemical structures of the grafted copolymers and its precursors are verified by FT-IR spectroscopy, NMR spectroscopy, and GPC characterizations. According to the DSC and XRD results, the polymorphisms of these grafted copolymers are mostly changed from semicrystalline to amorphous depending on the amount of grafted hydantoin. Antibacterial assays are carried out with Bacillus subtilis and two strains of Escherichia coli and show fast antibacterial action.
authors.affiliation: Department of Chemistry and Center of Materials Science, Philipps-Universität Marburg, Hans-Meerwein-Strasse, D-35042 Marburg, Germany.
authors.forename: Licheng
authors.initials: L
authors.lastname: Tan
authors.forename: Samarendra
authors.initials: S
authors.lastname: Maji
authors.forename: Claudia
authors.initials: C
authors.lastname: Mattheis
authors.forename: Yiwang
authors.initials: Y
authors.lastname: Chen
authors.forename: Seema
authors.initials: S
authors.lastname: Agarwal
mesh_terms: D000890:Anti-Infective Agents / Q000138:chemical synthesis* / Q000737:chemistry; D057930:Click Chemistry / Q000379:methods*; D006827:Hydantoins / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D011091:Polyesters / Q000737:chemistry*; D058105:Polymerization; D017550:Spectroscopy, Fourier Transform Infrared; D014961:X-Ray Diffraction
chemical_list: D000890:Anti-Infective Agents; D006827:Hydantoins; D011091:Polyesters; C016240:polycaprolactone