title: [Phenolic components from Petasites tricholobus].
abstract: OBJECTIVE
  To study the anti-inflammatory and antioxidant effects of Petasites tricholobus and its phenolic components.
  
  
  METHODS
  Phenolic compounds were separated purified by column chromatographic methods such as macroporous resin D-101, silica gel, ODS, MCI GEL CHP 20P, Sephadex LH-20. Their structures were identified on the basis of physicochemical property and multiple spectral data.
  
  
  RESULTS
  Nineteen phenolic compounds were separated from 95% ethanol extracts from P. tricholobus Franch. and identified as sulfonated benzyl glucoside (1), 3-(4beta-D-glucopyranosyloxy-3, 5-dimethoxy) -phenyl-2E-propenol (2), dihydrosyringin (3), tangshenosides II (4), 4-hydroxy-2,6-dimethoxyphenol-1-O-beta-D-glucopyranoside (5), 4-hydroxymethyl-2, 6-dimethoxyphenyl-1-O-beta-D-glucopyranoside (6), arbutin (7), rutin (8), kaempferol-3-O-alpha-L-rhamnopyranosyl-(1 --> 6)-beta-D-glucopyranoside (9), quercetin-3-O-beta-D-glucopyranoside (10), kaempferol-3-O-beta-D-glucopyranoside (11), afzelin (12), petasiphenol (13), caffeic acid (14), chlorogenic acid (15), 2-hydroxy-5-acetylbenzoic acid (16), p-hydroxy-benzoic acid (17), protocatechuic aldehyde (18) , and p-hydroxy-phenylpropionic acid (19).
  
  
  CONCLUSIONS
  Above result shows that phenolic compounds contained in P. tricholobus mainly include simple phenols, phenolic glycosides, coffee acid and flavonoid glycosides. Among them, compound 1 was separated from the composite family for the first time; compounds 2-7, 9, 11, 12, 16, 19 were separated from the genus Petasites for the first time, and the others were separated from the plant for the first time. These compounds have been proved to have pharmacological effects such as anti-inflammation, antibiosis, antioxidantion.
authors.affiliation: Department of Phytochemistry, School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China.
authors.forename: Yong
authors.initials: Y
authors.lastname: Zhang
authors.forename: Fujiang
authors.initials: F
authors.lastname: Guo
authors.forename: Peng
authors.initials: P
authors.lastname: Zeng
authors.forename: Qi
authors.initials: Q
authors.lastname: Jia
authors.forename: Yiming
authors.initials: Y
authors.lastname: Li
authors.forename: Weiliang
authors.initials: W
authors.lastname: Zhu
authors.forename: Kaixian
authors.initials: K
authors.lastname: Chen
mesh_terms: D000893:Anti-Inflammatory Agents / Q000032:analysis* / Q000302:isolation & purification; D000975:Antioxidants / Q000032:analysis* / Q000302:isolation & purification; D019659:Asteraceae / Q000737:chemistry*; D004365:Drugs, Chinese Herbal / Q000737:chemistry*; D010636:Phenols / Q000032:analysis* / Q000302:isolation & purification
chemical_list: D000893:Anti-Inflammatory Agents; D000975:Antioxidants; D004365:Drugs, Chinese Herbal; D010636:Phenols