title: Dysembryoplastic neuroepithelial tumor originally diagnosed as astrocytoma and oligodendroglioma.
abstract: Dysembryoplastic neuroepithelial tumor (DNT), described in 1988 and introduced in the WHO classification in 1993, affects predominantly children or young adults causing intractable complex partial seizures. Since it is benign and treated with surgical resection, its recognition is important. It has similarities with low-grade gliomas and gangliogliomas, which may recur and become malignant.
  
  
  OBJECTIVE
  To investigate whether DNT was previously diagnosed as astrocytoma, oligodendroglioma, or ganglioglioma and to determine its frequency in a series of low-grade glial/glio-neuronal tumors.
  
  
  METHODS
  Clinical, radiological, and histological aspects of 58 tumors operated from 1978 to 2008, classified as astrocytomas (32, including 8 pilocytic), oligodendrogliomas (12), gangliogliomas (7), and DNT (7), were reviewed.
  
  
  RESULTS
  Four new DNT, one operated before 1993, previously classified as astrocytoma (3) and oligodendroglioma (1), were identified. One DNT diagnosed in 2002 was classified once more as angiocentric glioma. Therefore, 10 DNT (17.2%) were identified.
  
  
  CONCLUSIONS
  Clinical-radiological and histopathological correlations have contributed to diagnose the DNT.
authors.affiliation: Universidade Federal do Rio de Janeiro (UFRJ), Rio de Janeiro RJ, Brazil.
authors.forename: Diego Cassol
authors.initials: DC
authors.lastname: Dozza
authors.forename: Flávio Freinkel
authors.initials: FF
authors.lastname: Rodrigues
authors.forename: Leila
authors.initials: L
authors.lastname: Chimelli
mesh_terms: D000293:Adolescent; D000328:Adult; D001254:Astrocytoma / Q000473:pathology; D001706:Biopsy; D001932:Brain Neoplasms / Q000473:pathology*; D002648:Child; D002675:Child, Preschool; D003937:Diagnosis, Differential; D004827:Epilepsy / Q000150:complications; D018303:Ganglioglioma / Q000473:pathology; D006801:Humans; D008279:Magnetic Resonance Imaging; D018302:Neoplasms, Neuroepithelial / Q000473:pathology*; D009837:Oligodendroglioma / Q000473:pathology; D012189:Retrospective Studies; D014057:Tomography, X-Ray Computed; D014944:World Health Organization; D055815:Young Adult