title: Monocyte chemoattractant protein-1 in dogs affected with neoplasia or inflammation.
abstract: Monocyte chemoattractant protein-1 (MCP-1) is a member of the C-C family chemokines, which mobilizes monocytes from bone marrow to the site of inflammation. To evaluate the clinical utility of canine MCP-1 as a blood test item, we measured serum MCP-1 concentrations in normal and ill dogs. Reference interval of canine MCP-1 was established as 115.6-176.9 pg/ml. Serum MCP-1 concentrations increased in the dogs affected with neoplastic (518.0 ± 84.8 pg/ml), inflammatory (257.0 ± 42.5 pg/ml) or other diseases (360.3 ± 45.2 pg/ml). The results showed high sensitivity of MCP-1 to detect neoplasia and inflammation. Moreover, MCP-1 increased in some cases in which C-reactive protein didn't increase. MCP-1 might be helpful as a screening blood test marker for detection of neoplasia and inflammation in dogs.
authors.affiliation: Department of Veterinary Nursing, School of Veterinary Nursing and Technology, Faculty of Veterinary Science, Nippon Veterinary and Life Science University, Tokyo, Japan. katsumi@nvlu.ac.jp
authors.forename: Katsumi
authors.initials: K
authors.lastname: Ishioka
authors.forename: Yumi
authors.initials: Y
authors.lastname: Suzuki
authors.forename: Kana
authors.initials: K
authors.lastname: Tajima
authors.forename: Sumire
authors.initials: S
authors.lastname: Ohtaki
authors.forename: Masahiro
authors.initials: M
authors.lastname: Miyabe
authors.forename: Mariko
authors.initials: M
authors.lastname: Takasaki
authors.forename: Akihiro
authors.initials: A
authors.lastname: Mori
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Momota
authors.forename: Daigo
authors.initials: D
authors.lastname: Azakami
authors.forename: Toshinori
authors.initials: T
authors.lastname: Sako
mesh_terms: D000818:Animals; D015415:Biomarkers; D018932:Chemokine CCL2 / Q000235:genetics / Q000378:metabolism*; D004283:Dog Diseases / Q000378:metabolism*; D004285:Dogs; D005260:Female; D005786:Gene Expression Regulation / Q000502:physiology; D007249:Inflammation / Q000378:metabolism / Q000662:veterinary*; D008297:Male; D009369:Neoplasms / Q000378:metabolism*
chemical_list: D015415:Biomarkers; D018932:Chemokine CCL2