title: [Three cases with high TARC levels of gastrointestinal food allergies in neonates and infants].
abstract: We measured serum TARC (Thymus and activation-regulated chemokine, CCL-17) levels in three patients of gastrointestinal food allergies in neonates and infants. Patient 1: 14-day-old girl. The chief complaints were poor feeding and weight loss. She tested peripheral eosinophilia (5820 /μL), high serum TARC levels (4730 pg/mL) and positive milk-specific IgE (1.53 UA/mL) at the time of onset. After change from cow' milk formula to hydrolyzed infant formulas and breast milk ahead of dairy products intake, the symptoms resolved. One month and a half later, she re-tested negative milk-specific IgE and normal serum TARC levels (198 pg/mL). Patient 2: 3-month-old girl. The chief complaint was vomiting after intake of cow' milk formula. She tested negative milk-specific IgE and very high serum TARC levels (25200 pg/mL) at the time of onset. After changing to hydrolyzed infant formulas and breast milk ahead of dairy products intake, the symptom resolved. Three months later, she re-tested positive milk-specific IgE (0.42 UA/mL) and normal serum TARC levels (1250 pg/mL). Patient 3: 21-day-old boy. The chief complaint was vomiting after intake of cow' milk formula. He tested peripheral eosinophilia (2923 /μL), very high serum TARC levels (49100 pg/mL) and positive milk-specific IgE (0.47 UA/mL) at the time of onset. After changing to hydrolyzed infant formulas and breast milk ahead of dairy products intake, the symptom resolved. Two weeks later, he re-tested negative milk-specific IgE and serum TARC levels (2210 pg/mL). Serum TARC may be related to the part of gastrointestinal food allergies in neonates and infants.
authors.affiliation: Department of Pediatrics, Showa General Hospital. kunihiro@zb3.so-net.ne.jp
authors.forename: Kunihiro
authors.initials: K
authors.lastname: Oba
authors.forename: Natsuko
authors.initials: N
authors.lastname: Obana
authors.forename: Kenta
authors.initials: K
authors.lastname: Hayashi
authors.forename: Takaya
authors.initials: T
authors.lastname: Murata
authors.forename: Ryoko
authors.initials: R
authors.lastname: Ishikawa
authors.forename: Yukiko
authors.initials: Y
authors.lastname: Taki
authors.forename: Tomohiro
authors.initials: T
authors.lastname: Yoshida
authors.forename: Masayuki
authors.initials: M
authors.lastname: Kokaji
mesh_terms: D015415:Biomarkers / Q000097:blood; D054414:Chemokine CCL17 / Q000097:blood*; D005260:Female; D006801:Humans; D006968:Hypersensitivity, Delayed / Q000097:blood / Q000175:diagnosis; D007223:Infant; D007231:Infant, Newborn; D016269:Milk Hypersensitivity / Q000097:blood* / Q000175:diagnosis
chemical_list: D015415:Biomarkers; D054414:Chemokine CCL17