title: Cytotoxic iridoids from the roots of Patrinia scabra.
abstract: Six new iridoid glucosides, patriridosides D-I (1-6), and one new iridoid, scabrol A (7), along with 12 known non-glycosidic and glycosidic iridoids (8-19), have been isolated from an ethanolic extract of the roots of Patrinia scabra. The cytotoxic activity of the isolated compounds against human cervical carcinoma HeLa cells and gastric carcinoma MNK-45 cells was evaluated using the MTT assay. Compounds 1, 4-6, 8, and 18 showed cytotoxic activities against the MNK-45 cell line with respective IC₅₀ values of 15.6, 8.7, 9.4, 30.9, 23.8, and 11.2 μM, while only compound 10 showed cytotoxicity against the HeLa cell line, with an IC₅₀ value of 24.5 μM.
authors.affiliation: Anhui Key Laboratory of Bioactivity of Natural Products, School of Pharmacy, Anhui Medical University, 81 Meishan Road, Hefei 230032, People's Republic of China. ln0110@sina.com
authors.forename: Ning
authors.initials: N
authors.lastname: Li
authors.forename: Lei
authors.initials: L
authors.lastname: Di
authors.forename: Wen-Chao
authors.initials: WC
authors.lastname: Gao
authors.forename: Kai-Jin
authors.initials: KJ
authors.lastname: Wang
authors.forename: Ling-Bo
authors.initials: LB
authors.lastname: Zu
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D045744:Cell Line, Tumor; D004354:Drug Screening Assays, Antitumor; D006367:HeLa Cells; D006801:Humans; D057888:Iridoid Glucosides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D039823:Iridoids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D015394:Molecular Structure; D032405:Patrinia / Q000737:chemistry*; D018517:Plant Roots / Q000737:chemistry
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D057888:Iridoid Glucosides; D039823:Iridoids; C577672:scabrol A