title: Subthreshold transpupillary thermotherapy in management of foveal subretinal fluid in small pigmented choroidal lesions.
abstract: OBJECTIVE
  To evaluate the effect of subthreshold transpupillary thermotherapy (sTTT) in foveal subretinal fluid of small pigmented choroidal lesions.
  
  
  METHODS
  Retrospective, noncomparative, interventional case series. We reviewed patients with small pigmented choroidal lesions presenting foveal subretinal fluid and treated with sTTT to evaluate fluid regression.
  
  
  RESULTS
  We treated 13 patients with small pigmented choroidal lesions with a mean height of 2.02 ± 0.54 mm (range, 1.4-2.9 mm) and a mean largest diameter of 7.60 ± 1.98 mm (range, 5-11 mm). In 11 cases, foveal subretinal fluid was completely resolved (84.6%), with a mean follow-up of 42.46 ± 26.29 months (range, 12-103 months). The mean number of sTTT sessions applied was 1.38 ± 0.77 (range, 1-3 sessions), at a mean spot size of 1,570.59 ± 795.1 μm (range, 500-3,000 μm), and overall exposure time of 2.32 ± 1.2 minutes (range, 1-6 minutes). Mean laser power applied was 370.63 ± 162.87 mW (range, 200 to 600 mW). Best-corrected visual acuity at the time of diagnosis was maintained or improved in 69.3% of patients after sTTT treatment. During follow-up, tumor progression was reported in 5 cases, regardless of the presence of subretinal fluid. These cases were treated promptly with brachytherapy.
  
  
  CONCLUSIONS
  However, sTTT may be effective in solving foveal subretinal fluid in small pigmented choroidal lesions, attaining satisfactory visual acuity in most cases.
authors.affiliation: Ocular Oncology Unit, Department of Ophthalmology, Bellvitge University Hospital, L'Hospitalet de Llobregat, Barcelona, Spain. jmcaminal@gmail.com
authors.forename: Jose M
authors.initials: JM
authors.lastname: Caminal
authors.forename: Karol A
authors.initials: KA
authors.lastname: Mejia-Castillo
authors.forename: Luis
authors.initials: L
authors.lastname: Arias
authors.forename: Jaume
authors.initials: J
authors.lastname: Catala
authors.forename: Marc
authors.initials: M
authors.lastname: Rubio
authors.forename: Pere
authors.initials: P
authors.lastname: Garcia
authors.forename: Octavi
authors.initials: O
authors.lastname: Pujol
authors.forename: Jorge
authors.initials: J
authors.lastname: Arruga
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002830:Choroid Neoplasms / Q000175:diagnosis / Q000378:metabolism / Q000628:therapy*; D005260:Female; D005451:Fluorescein Angiography; D005584:Fovea Centralis / Q000378:metabolism*; D006801:Humans; D006979:Hyperthermia, Induced; D008297:Male; D008545:Melanoma / Q000175:diagnosis / Q000378:metabolism / Q000628:therapy*; D008875:Middle Aged; D009508:Nevus, Pigmented / Q000175:diagnosis / Q000378:metabolism / Q000628:therapy*; D011680:Pupil; D012189:Retrospective Studies; D058471:Subretinal Fluid / Q000378:metabolism*; D041623:Tomography, Optical Coherence; D014792:Visual Acuity / Q000502:physiology; D055815:Young Adult