title: [The positive effect of short-term haloperidol administration on the dysfunction of brain metabolism and neuronal activity].
abstract: Chronic amphetamine injection increased spontaneous neuronal activity in sensomotor cortex and decreased spike activity in caudate nucleus. The neuronal ability to perform the conditioned reactions was greater in the cortex and smaller in the nucleus caudatus. By biochemical investigations it was showed the hyperactivity of dopaminergic system in the caudate nucleus compared to that in sensomotor cortex. During chronic amphetamine administration haloperidol caused effects similar to the ones caused by amphetamine on neuronal spike activity in sensomotor cortex and did not influence spike activity and neuronal conditioned reactions in the caudate nucleus. The short-term haloperidol action reduced the enzymes activity and particularly the biogenic amines level leading to the normalization of transmitter metabolism.
authors.forename: F V
authors.initials: FV
authors.lastname: Kopytova
authors.forename: E L
authors.initials: EL
authors.lastname: Dovedova
mesh_terms: D000200:Action Potentials / Q000187:drug effects / Q000502:physiology; D000661:Amphetamine / Q000008:administration & dosage / Q000009:adverse effects; D000818:Animals; D001923:Brain Chemistry / Q000187:drug effects* / Q000502:physiology; D002421:Caudate Nucleus / Q000187:drug effects / Q000502:physiology; D002540:Cerebral Cortex / Q000187:drug effects / Q000502:physiology; D003213:Conditioning, Psychological / Q000187:drug effects; D018492:Dopamine Antagonists / Q000008:administration & dosage* / Q000627:therapeutic use; D018765:Dopamine Uptake Inhibitors / Q000008:administration & dosage / Q000009:adverse effects; D004334:Drug Administration Schedule; D006220:Haloperidol / Q000008:administration & dosage* / Q000627:therapeutic use; D008297:Male; D008839:Microelectrodes; D009474:Neurons / Q000187:drug effects* / Q000502:physiology; D011817:Rabbits; D051381:Rats; D017208:Rats, Wistar
chemical_list: D018492:Dopamine Antagonists; D018765:Dopamine Uptake Inhibitors; D000661:Amphetamine; D006220:Haloperidol