title: [Pharmacological intervention of conditioned fear and its extinction].
abstract: Conditioned fear and its abnormal extinction are involved in the psychopathology of anxiety disorders, such as posttraumatic stress disorder (PTSD). Cognitive enhancing agents have been demonstrated to alter fear extinction in many animal research literatures. The present review has examined the pharmacological role of gamma-aminobutyric acid (GABA), glutamatergic, cholinergic, adrenergic, dopaminergic, and cannabinoid as well as compounds able to alter the epigenetic and neurotrophic mechanism in fear extinction, highlighting great hope for the future treatment of anxiety disorders with new agents based on the fear extinction.
authors.affiliation: Department of Teaching Science, Hunan First Normal College, Changsha, China.
authors.forename: Renzhi
authors.initials: R
authors.lastname: Huang
authors.forename: Zexuan
authors.initials: Z
authors.lastname: Li
authors.forename: Huan
authors.initials: H
authors.lastname: Chen
authors.forename: Yuesheng
authors.initials: Y
authors.lastname: Huang
authors.forename: Liping
authors.initials: L
authors.lastname: Ding
mesh_terms: D000818:Animals; D001008:Anxiety Disorders / Q000188:drug therapy / Q000523:psychology*; D002186:Cannabinoids / Q000494:pharmacology / Q000627:therapeutic use; D003213:Conditioning, Psychological / Q000187:drug effects*; D005108:Extinction, Psychological / Q000187:drug effects; D005239:Fear / Q000187:drug effects* / Q000523:psychology*; D006801:Humans; D018697:Nootropic Agents / Q000494:pharmacology*; D013313:Stress Disorders, Post-Traumatic / Q000188:drug therapy / Q000523:psychology; D005680:gamma-Aminobutyric Acid / Q000494:pharmacology / Q000627:therapeutic use
chemical_list: D002186:Cannabinoids; D018697:Nootropic Agents; D005680:gamma-Aminobutyric Acid