title: Biotin-binding proteins in the defense of mushrooms against predators and parasites.
abstract: Tamavidins are fungal biotin-binding proteins (BBPs) displaying antifungal activity against phytopathogens. Here we show high toxicity of tamavidins toward nematodes, insects, and amoebae. As these organisms represent important phyla of fungal predators and parasites, we propose that BBPs are part of the chemical defense system of fungi.
authors.affiliation: Institute of Microbiology, Department of Biology, ETH Zürich, Zürich, Switzerland.
authors.forename: Silvia
authors.initials: S
authors.lastname: Bleuler-Martinez
authors.forename: Stefanie
authors.initials: S
authors.lastname: Schmieder
authors.forename: Markus
authors.initials: M
authors.lastname: Aebi
authors.forename: Markus
authors.initials: M
authors.lastname: Künzler
mesh_terms: D000363:Agaricales / Q000378:metabolism*; D000656:Amoeba / Q000187:drug effects; D000818:Animals; D000898:Antibiosis; D002352:Carrier Proteins / Q000378:metabolism*; D005656:Fungal Proteins / Q000378:metabolism*; D007313:Insecta / Q000187:drug effects; D009348:Nematoda / Q000187:drug effects; D010271:Parasites / Q000187:drug effects*
chemical_list: D002352:Carrier Proteins; D005656:Fungal Proteins; C017071:biotin-binding proteins