title: Is vitamin D status a predictor glycaemic regulation and cardiac complication in type 2 diabetes mellitus patients?
abstract: OBJECTIVE
  To evaluate vitamin D as a predictor of glycaemic regulation in type 2 diabetes mellitus patients.
  
  
  METHODS
  In observational study 171 type 2 diabetic patients who are followed for median (range) of 10.15 (3-18) years. Mean ± SD age was 56 ± 10. Plasma 25-hydroxyvitamin D3 levels were determined by high-performance liquid chromatography/tandem mass spectrometry on baseline samples. Vitamin D deficiency was defined as a 25-OHD level of less than 20 ng/ml. Vitamin D levels between 20 and 30 ng/ml are termed 'insufficient'. Vitamin D levels greater than 30 ng/ml are termed 'optimal'.
  
  
  RESULTS
  125 patients have vitamin D deficiency, 14 patients have insufficient and the others have optimal. Vitamin D levels were not associated with sex, age, BMI, HDL, LDL, kreatinin, hypertension and smoking. But vitamin D deficiency patients had more longer duration (p=0.011), more higher uric acid (p=0.021), fasting glucose (p=0.037), postprandial glucose (p=0.001) and HbA1c (p=0.026).
  
  
  CONCLUSIONS
  In our study type 2 diabetic patients have 73% of vitamin D deficiency. Vitamin D deficiency predicts higher fasting and postprandial blood glucose and diabetes disregulation. Type 2 DM patients and low 25-OH vitamin D levels could increased cardiovascular disease directly or indirectly (low HDL and high uric acid in 25-OH vitamin D <20 ng/ml). Whether vitamin D substitution improves prognosis remains to be investigated.
authors.affiliation: Dışkapı Yıldırım Beyazıt Training and Researching Hospital, Department of Endocrinology and Metabolism, Ankara, Turkey. drhakkiyilmaz@yahoo.com
authors.forename: Hakki
authors.initials: H
authors.lastname: Yilmaz
authors.forename: Mustafa
authors.initials: M
authors.lastname: Kaya
authors.forename: Mustafa
authors.initials: M
authors.lastname: Sahin
authors.forename: Tuncay
authors.initials: T
authors.lastname: Delibasi
mesh_terms: D001786:Blood Glucose / Q000378:metabolism*; D002851:Chromatography, High Pressure Liquid; D015897:Comorbidity; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000150:complications*; D058065:Diabetic Cardiomyopathies / Q000097:blood / Q000209:etiology*; D005260:Female; D005951:Glucose Tolerance Test; D006442:Glycated Hemoglobin / Q000378:metabolism; D006801:Humans; D006943:Hyperglycemia / Q000097:blood; D007328:Insulin / Q000097:blood; D008297:Male; D008875:Middle Aged; D012016:Reference Values; D053719:Tandem Mass Spectrometry; D014807:Vitamin D / Q000031:analogs & derivatives / Q000097:blood; D014808:Vitamin D Deficiency / Q000097:blood*
chemical_list: D001786:Blood Glucose; D006442:Glycated Hemoglobin; D007328:Insulin; D014807:Vitamin D; C517652:hemoglobin A1c protein, human; C104450:25-hydroxyvitamin D