title: Ready access to a branched Man5 oligosaccharide based on regioselective glycosylations of a mannose-tetraol with n-pentenyl orthoesters.
abstract: A branched Man(5) oligosaccharide has been synthesized by sequential regioselective glycosylations on a mannose-tetraol with n-pentenyl orthoester glycosyl-donors promoted by NIS/BF(3)·Et(2)O, in CH(2)Cl(2). An extended n-pentenyl chain was incorporated into the tetraol acceptor to facilitate (a) the solubility of the starting tetraol in CH(2)Cl(2), and (b) future manipulations at the reducing end of the Man(5) oligosaccharide.
authors.affiliation: Instituto de Química Orgánica General, Madrid, Spain.
authors.forename: Clara
authors.initials: C
authors.lastname: Uriel
authors.forename: Ana M
authors.initials: AM
authors.lastname: Gómez
authors.forename: J Cristóbal
authors.initials: JC
authors.lastname: López
authors.forename: Bert
authors.initials: B
authors.lastname: Fraser-Reid
mesh_terms: D002240:Carbohydrate Sequence; D004952:Esters / Q000737:chemistry*; D006031:Glycosylation; D008351:Mannans / Q000737:chemistry*; D008358:Mannose / Q000737:chemistry*; D008969:Molecular Sequence Data; D009844:Oligosaccharides / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D004952:Esters; D008351:Mannans; D009844:Oligosaccharides; C057328:mannosyl(9)-N-acetylglucosamine; D008358:Mannose