title: Assessment of biochemical profiles in premenopausal and postmenopausal women with breast cancer.
abstract: OBJECTIVE
  The study was conducted to assess biochemical profiles in premenopausal and postmenopausal women having breast cancer.
  
  
  METHODS
  A hospital based case control study was carried out at Manipal Teaching Hospital (MTH), Pokhara, Nepal. The analysed variables were age, metabolic profile including total cholesterol, triglycerides, HDL-C, LDL-C, blood sugar, insulin concentration, C-peptide, HbA1c and selenium. Descriptive statistics and testing of hypothesis were used for the analysis using EPI INFO and SPSS 16 software.
  
  
  RESULTS
  In premenopausal women, significant differences were noted for total cholesterol (P value <0.001), triglycerides (P value 0.002), HbA1c level (P value <0.001), insulin concentration (P value 0.030), C-peptide concentration (P value 0.001), and selenium (P value <0.001) between cases and controls. Insignificant results were found for HDL-C (P value 0.749), LDL-C (P value 0.933), blood sugar (P value 0.59) and BMI (P value 0.746). Similarly, significant difference in total cholesterol (P value <0.001), triglycerides (P value 0.001), LDL-C (P value <0.001), HDL-C (P value 0.025), blood sugar (P value <0.001), insulin concentration (P value <0.001), c-peptide concentration (P value <0.001), HbA1c level (P value <0.001) and selenium (P value <0.001) were observed for postmenopausal patients and controls.
  
  
  CONCLUSIONS
  Assessing metabolic changes and their management may be important for control of breast cancer and increased survival.
authors.affiliation: Department of Biochemistry, Manipal College of Medical Sciences, Pokhara, Nepal. naval.rhythm@gmail.com
authors.forename: Naval Kishor
authors.initials: NK
authors.lastname: Yadav
authors.forename: Bibek
authors.initials: B
authors.lastname: Poudel
authors.forename: C
authors.initials: C
authors.lastname: Thanpari
authors.forename: Bidhan
authors.initials: B
authors.lastname: Chandra Koner
mesh_terms: D000328:Adult; D000368:Aged; D001786:Blood Glucose / Q000378:metabolism; D001943:Breast Neoplasms / Q000097:blood / Q000378:metabolism*; D002096:C-Peptide / Q000097:blood / Q000378:metabolism; D016022:Case-Control Studies; D008076:Cholesterol, HDL / Q000097:blood / Q000378:metabolism; D008078:Cholesterol, LDL / Q000097:blood / Q000378:metabolism; D005260:Female; D006442:Glycated Hemoglobin / Q000378:metabolism; D006801:Humans; D007328:Insulin / Q000097:blood / Q000378:metabolism; D008875:Middle Aged; D017698:Postmenopause / Q000097:blood / Q000378:metabolism*; D017697:Premenopause / Q000097:blood / Q000378:metabolism*; D012643:Selenium / Q000097:blood / Q000378:metabolism; D014280:Triglycerides / Q000097:blood / Q000378:metabolism
chemical_list: D001786:Blood Glucose; D002096:C-Peptide; D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D006442:Glycated Hemoglobin; D007328:Insulin; D012643:Selenium; D014280:Triglycerides; C517652:hemoglobin A1c protein, human