title: Large medial sphenoid wing meningiomas: long-term outcome and correlation with tumor size after microsurgical treatment in 127 consecutive cases.
abstract: OBJECTIVE
  We present the long-term outcomes as well as their correlation with tumor     size in 127 consecutive patients harboring large MSWM after microsurgical     treatment.
  
  
  METHODS
  The retrospective analysis of clinical data and     follow-up data of 127 microsurgical treated patients with MSWM was performed.     The mean maximum diameter of tumors was 5.2cm (ranged 1.5-10.0cm).
  
  
  RESULTS
  104     cases (81.9%) achieved gross total resection. There was no operative mortality.     Detailed follow-up data was available in 120 cases for a mean duration of 81.6     months (12-216 months). The permanent morbidity was 14.2%. The mean KPS score 1     year after surgery was 90.6 (ranged 60-100). Among 74 patients of preoperative     visual acuity (VA) impairment, postoperative VA improved in 42 cases (56.8%),     unchanged in 30 (40.5%), and deteriorated in 2 (2.7%). MR images revealed tumor     recurrence after total resection in 10 cases (10.2%) and tumor progression after     subtotal resection in 10 cases (45.5%).
  
  
  CONCLUSIONS
  Tumor recurrence was the     major risk in the long run, thus the initial surgery was extremely important and     hence should be aggressive. The size of tumor affected the extent of tumor     removal determining clinical outcomes including VA improvement and KPS score     immediately after surgery; however, it was not correlated with long-term overall     outcomes.
authors.affiliation: Xiangya Hospital, Central South University, The Institute of Skull Base Surgery and Neurooncology at Hunan, Department of Neurosurgery, Changsha, Hunan, China.
authors.forename: Ding-yang
authors.initials: DY
authors.lastname: Liu
authors.forename: Xian-rui
authors.initials: XR
authors.lastname: Yuan
authors.forename: Qing
authors.initials: Q
authors.lastname: Liu
authors.forename: Xin-jun
authors.initials: XJ
authors.lastname: Jiang
authors.forename: Wei-Xi
authors.initials: WX
authors.lastname: Jiang
authors.forename: Ze-feng
authors.initials: ZF
authors.lastname: Peng
authors.forename: Xi-ping
authors.initials: XP
authors.lastname: Ding
authors.forename: Duan-wu
authors.initials: DW
authors.lastname: Luo
authors.forename: Jian
authors.initials: J
authors.lastname: Yuan
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D018450:Disease Progression; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D017567:Karnofsky Performance Status; D008297:Male; D008579:Meningioma / Q000473:pathology* / Q000601:surgery*; D008866:Microsurgery / Q000379:methods*; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local; D009460:Neurologic Examination; D019635:Neurosurgical Procedures / Q000379:methods*; D011183:Postoperative Complications / Q000453:epidemiology; D011788:Quality of Life; D012189:Retrospective Studies; D012888:Skull Neoplasms / Q000473:pathology* / Q000601:surgery*; D013100:Sphenoid Bone / Q000473:pathology* / Q000601:surgery*; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome; D055815:Young Adult