title: Multicomponent assembly of highly substituted indoles by dual palladium-catalyzed coupling reactions.
abstract: Highly substituted indoles were synthesized by a palladium-catalyzed reaction involving three independent components in a one-pot reaction. Two distinct palladium-catalyzed coupling reactions occur with a single catalytic system: a Buchwald-Hartwig reaction and an arene-alkene coupling. Quantum chemical computations provide insight into the mechanism of the latter coupling step.
authors.affiliation: Department of Chemistry, University of California Davis, 1 Shields Ave., Davis, CA 95616, USA.
authors.forename: John M
authors.initials: JM
authors.lastname: Knapp
authors.forename: Jie S
authors.initials: JS
authors.lastname: Zhu
authors.forename: Dean J
authors.initials: DJ
authors.lastname: Tantillo
authors.forename: Mark J
authors.initials: MJ
authors.lastname: Kurth
mesh_terms: D000588:Amines / Q000737:chemistry; D001555:Benzene Derivatives / Q000737:chemistry; D002384:Catalysis; D007211:Indoles / Q000138:chemical synthesis*; D008968:Molecular Conformation; D010165:Palladium / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D000588:Amines; D001555:Benzene Derivatives; D007211:Indoles; D010165:Palladium