title: [The methods for the protection against counterfeit medications. Part 1. The estimation of the quality of metoprolol succinate substance and tablets from different manufacturers in terms of "identity" and "active ingredient content"].
abstract: This paper was designed to report the results of analysis of metoprolol succinate substance and tablets obtained from two manufacturers, Akrikhin (Russia) and AstraZeneca (Sweden). The analysis was performed by spectroscopy in the near IR region and followed by the chemometric treatment of the data obtained. The method was used to confirm the "identity" of metoprolol succinate tablets. The approach to distinguishing the differences between pharmaceutical dosage forms produced by different manufacturers is proposed. Also, the method for the qualitative determination of metoprolol succinate in the pharmaceutical formulations has been developed.
authors.forename: V A
authors.initials: VA
authors.lastname: Iakushev
authors.forename: M A
authors.initials: MA
authors.lastname: Morozova
authors.forename: T E
authors.initials: TE
authors.lastname: Elizarova
authors.forename: S B
authors.initials: SB
authors.lastname: Fitilev
authors.forename: T V
authors.initials: TV
authors.lastname: Pletneva
mesh_terms: D002138:Calibration; D002626:Chemistry, Pharmaceutical; D058110:Counterfeit Drugs / Q000032:analysis*; D016002:Discriminant Analysis; D004345:Drug Industry / Q000592:standards*; D008790:Metoprolol / Q000031:analogs & derivatives* / Q000032:analysis / Q000592:standards; D010602:Pharmacopoeias as Topic; D011044:Poland; D011786:Quality Control; D012426:Russia; D019265:Spectroscopy, Near-Infrared / Q000295:instrumentation / Q000379:methods*; D013548:Sweden; D013607:Tablets
chemical_list: D058110:Counterfeit Drugs; D013607:Tablets; D008790:Metoprolol