title: Intrinsic skin aging: the role of oxidative stress.
abstract: Skin aging appears to be the result of two overlapping processes, intrinsic and extrinsic. It is well accepted that oxidative stress contributes significantly to extrinsic skin aging, although findings point towards reactive oxygen species (ROS) as one of the major causes of and single most important contributor; not only does ROS production increase with age, but human skin cells' ability to repair DNA damage steadily decreases over the years. We extrapolated mechanisms of intrinsic oxidative stress in tissues other than skin to the skin cells in order to provide effective anti-aging strategies and reviewed the literature on intrinsic skin aging and the role of oxidative stress.
authors.affiliation: Faculty of Health Studies, University of Ljubljana, Zdravstvena pot 5, SI-1000 Ljubljana, Slovenia.
authors.forename: Borut
authors.initials: B
authors.lastname: Poljšak
authors.forename: Raja G
authors.initials: RG
authors.lastname: Dahmane
authors.forename: Aleksandar
authors.initials: A
authors.lastname: Godić
mesh_terms: D000368:Aged; D000375:Aging / Q000235:genetics* / Q000502:physiology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D018384:Oxidative Stress / Q000235:genetics / Q000502:physiology*; D017382:Reactive Oxygen Species / Q000378:metabolism*; D018570:Risk Assessment; D012680:Sensitivity and Specificity; D015595:Skin Aging / Q000235:genetics / Q000502:physiology*; D013997:Time Factors
chemical_list: D017382:Reactive Oxygen Species