title: [Case of suspected malignant hyperthermia following local infiltration anesthesia].
abstract: A 49-year-old man with no past history of malignant hyperthermia (MH) and scheduled for hernia repair was suspected of MH after local infiltration anesthesia at other hospital. Although intravenous diazepam was not effective for increased body temperature, tachycardia, and convulsion, dantrolene was effective for these signs. However, blood test showed no abnormal finding. At our hospital, he was scheduled for hernia repair and muscle biopsy under total intravenous anesthesia. No event occurred intra- and postoperatively. The examination for muscle biopsy revealed that the function of his ryanodine receptor 1 is abnormal. The events which had occurred at other hospital were uncertain of being associated with MH.
authors.affiliation: Department of Anesthesia, Toyama Prefectural Central Hospital, Toyama 930-8550.
authors.forename: Kazuo
authors.initials: K
authors.lastname: Kamitani
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Yoshida
authors.forename: Riho
authors.initials: R
authors.lastname: Arai
authors.forename: Koso
authors.initials: K
authors.lastname: Matsuura
authors.forename: Harumi
authors.initials: H
authors.lastname: Miyoshi
authors.forename: Yasuko
authors.initials: Y
authors.lastname: Kuroda
mesh_terms: D000771:Anesthesia, Intravenous; D000772:Anesthesia, Local / Q000009:adverse effects*; D001706:Biopsy; D003620:Dantrolene / Q000627:therapeutic use; D006552:Hernia, Inguinal / Q000601:surgery; D059685:Herniorrhaphy; D006801:Humans; D008297:Male; D008305:Malignant Hyperthermia / Q000188:drug therapy / Q000209:etiology*; D008875:Middle Aged; D018482:Muscle, Skeletal / Q000473:pathology; D019990:Perioperative Care; D019837:Ryanodine Receptor Calcium Release Channel / Q000235:genetics
chemical_list: D019837:Ryanodine Receptor Calcium Release Channel; D003620:Dantrolene