title: Vanishing testes: a literature review.
abstract: Vanishing testes syndrome is often referred to as testicular regression syndrome (TRS) in the recent medical literature. The most characteristic histological findings are presence of a fibrovascular nodule with associated hemosiderin-laden macrophages and dystrophic calcification. Residual testicular tubules are found in less than 10% of cases, with prevalence being unrelated to age at surgery. Presence of seminiferous tubules and viable germ cells in testicular remnant tissue has been reported in some series. TRS theoretically carries a potential for malignant degeneration in the long term and therefore removal of any remnant is a common practice to eliminate this risk. However, no case series has reported germinal dysplasia or intratubular germ cell neoplasia in any of the specimens taken from these patients.
authors.affiliation: Süleyman Demirel University Faculty of Medicine, Department of Pediatric Endocrinology and Diabetes, Isparta, Turkey. ozgurpirgon@gmail.com
authors.forename: Özgür
authors.initials: Ö
authors.lastname: Pirgon
authors.forename: Bumin Nuri
authors.initials: BN
authors.lastname: Dündar
mesh_terms: D006061:Gonadal Dysgenesis, 46,XY / Q000175:diagnosis / Q000453:epidemiology / Q000503:physiopathology* / Q000628:therapy; D006801:Humans; D008297:Male; D015995:Prevalence; D013737:Testis / Q000002:abnormalities / Q000503:physiopathology