title: [Factors of intravascular hemolysis in cardiosurgical patients after cardiopulmonary bypass procedures].
abstract: The study included patients with ischemic heart disease with moderate (52 patients) and apparent (23 patients) hemolysis after coronary bypass surgery in cardiopulmonary bypass (CB). The concentration of free hemoglobin in blood plasma, mechanical resistance and sorption capacity of red cells as well as the content of TBA-active products, cholesterol and phospholipids in red cells and reticulocytes levels in blood were studied before and after operation. It was shown that among patients with apparent post-perfusion hemolysis (in contrast to the patients with a moderate hemolysis) the sorption capacity of red cells and amount of reticulocytes in blood are increased before operation; level of TBA-active products in erythrocytes is increasing after operation. Development of moderate hemolysis is associated with the decreased mechanical resistance of erythrocytes and increased cholesterol/phospholipid-ratio in membranes before operation. Thus, individually-specified apparent post-perfusion hemolysis is based on free-radical mechanism of erythrocytes damage and moderate hemoglobin level is referred to mechanical trauma of blood cells during CB.
authors.forename: S P
authors.initials: SP
authors.lastname: Chumakova
authors.forename: O I
authors.initials: OI
authors.lastname: Urazova
authors.forename: V V
authors.initials: VV
authors.lastname: Novitskiĭ
authors.forename: V M
authors.initials: VM
authors.lastname: Shipulin
authors.forename: I V
authors.initials: IV
authors.lastname: Mal'tseva
authors.forename: O A
authors.initials: OA
authors.lastname: Khokhlov
authors.forename: T V
authors.initials: TV
authors.lastname: Emel'ianova
authors.forename: O V
authors.initials: OV
authors.lastname: Iurlova
mesh_terms: D000368:Aged; D002315:Cardiopulmonary Bypass / Q000009:adverse effects* / Q000379:methods; D001026:Coronary Artery Bypass / Q000379:methods*; D004912:Erythrocytes / Q000378:metabolism / Q000473:pathology; D005260:Female; D005609:Free Radicals / Q000378:metabolism; D006452:Hemoglobinometry / Q000379:methods; D006454:Hemoglobins / Q000032:analysis; D006461:Hemolysis; D006801:Humans; D008297:Male; D008563:Membrane Lipids / Q000378:metabolism; D008875:Middle Aged; D009996:Osmotic Fragility; D010107:Oxygenators, Membrane / Q000009:adverse effects*; D017701:Reticulocyte Count; D012156:Reticulocytes / Q000378:metabolism; D012720:Severity of Illness Index
chemical_list: D005609:Free Radicals; D006454:Hemoglobins; D008563:Membrane Lipids