title: [Association of cytotoxic T lymphocyte-associated antigen-4+49A/G polymorphism with childhood type 1 diabetes mellitus: a meta-analysis].
abstract: OBJECTIVE
  To evaluate the association of cytotoxic T lymphocyte-associated antigen-4 (CTLA-4) + 49A/G polymorphism with type 1 diabetes mellitus (T1DM) in children.
  
  
  METHODS
  Papers about the association of CTLA4+49A/G polymorphism with T1DM in children were collected by searching PubMed, EBSCO, CBM, CNKI, and Wanfang Data. A meta-analysis was performed to examine differences in the genotypes (AG, GG, and GG+AG) and G allele at position 49 of the CTLA-4 gene between a childhood T1DM group and a control group.
  
  
  RESULTS
  A total of 10 papers involving 1084 T1DM children and 1338 healthy children were included. The Meta-analysis was performed to evaluate the association of the genotypes (AG, GG, and GG+AG) and the G allele at position 49 of the CTLA-4 gene with T1DM using a fixed effect model according to the heterogeneity test results of all studies. The pooled OR values (95% CI) were 1.13 (0.97-1.33), 1.42 (1.16-1.75), 1.20 (1.03-1.40), and 1.21 (1.09-1.33), suggesting a significant difference in genotypes (AG, GG, and GG+AG) and the G allele at position 49 of the CTLA-4 gene between the two groups.
  
  
  CONCLUSIONS
  CTLA-4 +49A/G polymorphism is associated with T1DM in children.
authors.affiliation: Department of Endocrinology, Zhengzhou Children's Hospital, Zhengzhou, China.
authors.forename: Shu-Ying
authors.initials: SY
authors.lastname: Luo
authors.forename: Li-Na
authors.initials: LN
authors.lastname: Tan
authors.forename: Hai-Yan
authors.initials: HY
authors.lastname: Wei
authors.forename: Yao-Dong
authors.initials: YD
authors.lastname: Zhang
authors.forename: Yong-Xing
authors.initials: YX
authors.lastname: Chen
mesh_terms: D060908:CTLA-4 Antigen / Q000235:genetics*; D003922:Diabetes Mellitus, Type 1 / Q000235:genetics*; D005838:Genotype; D006801:Humans; D011110:Polymorphism, Genetic
chemical_list: D060908:CTLA-4 Antigen; C556706:CTLA4 protein, human