title: Increase in mitochondrial DNA copy number in response to ochratoxin A and methanol-induced mitochondrial DNA damage in Drosophila.
abstract: The current study examined the effects of ochratoxin A (OTA) and methanol on mitochondrial DNA (mtDNA). The results showed that methanol application caused approximately 29 % more damage than the control group, and that there were no significant differences among the other groups in terms of mtDNA damage. The application of 0.04 ng/mL OTA and 0.04 ng/mL OTA with methanol increased mtDNA copy number compared with the control and 0.005 ng/mL OTA with methanol groups. The copy number in the 0.04 ng/mL OTA group was approximately 16 % greater than in the control.
authors.affiliation: Department of Biology, Mehmet Akif Ersoy University, Burdur, Turkey. agmutlu@gmail.com
authors.forename: Ayse Gul
authors.initials: AG
authors.lastname: Mutlu
mesh_terms: D000818:Animals; D002273:Carcinogens / Q000633:toxicity*; D004249:DNA Damage; D004272:DNA, Mitochondrial / Q000502:physiology*; D004330:Drosophila; D005506:Food Contamination; D000432:Methanol / Q000633:toxicity*; D009793:Ochratoxins / Q000633:toxicity*
chemical_list: D002273:Carcinogens; D004272:DNA, Mitochondrial; D009793:Ochratoxins; C025589:ochratoxin A; D000432:Methanol