title: External evaluation of the Dimension Vista 1500® intelligent lab system.
abstract: BACKGROUND
  Dimension Vista® analyzer combines four technologies (photometry, nephelometry, V-LYTE® integrated multisensor potentiometry, and LOCI® chemiluminescence) into one high-throughput system.
  
  
  METHODS
  We assessed analytical performance of assays routinely performed in our emergency laboratory according to the VALTEC protocol, and practicability.
  
  
  RESULTS
  Precision was good for most parameters. Analytical domain was large and suitable for undiluted analysis in most clinical settings encountered in our hospital. Data were comparable and correlated to our routine analyzers (Roche Modular DP®, Abbott AXSYM®, Siemens Dimension® RxL, and BN ProSpec®). Performance of nephelometric and LOCI modules was excellent. Functional sensitivity of high-sensitivity C-reactive protein and cardiac troponin I were 0.165 mg/l and 0.03 ng/ml, respectively (coefficient of variation; CV < 10%). The influence of interfering substances (i.e., hemoglobin, bilirubin, or lipids) was moderate, and Dimension Vista® specifically alerted for interference according to HIL (hemolysis, icterus, lipemia) indices. Good instrument performance and full functionality (no reagent or sample carryover in the conditions evaluated, effective sample-volume detection, and clot detection) were confirmed. Simulated routine testing demonstrated excellent practicability, throughput, ease of use of software and security.
  
  
  CONCLUSIONS
  Performance and practicability of Dimension Vista® are highly suitable for both routine and emergency use. Since no volume detection and thus no warning is available on limited sample racks, pediatric samples require special caution to the Siemens protocol to be analyzed in secured conditions. Our experience in routine practice is also discussed, i.e., the impact of daily workload, "manual" steps resulting from dilutions and pediatric samples, maintenances, flex hydration on instrument's performance on throughput and turnaround time.
authors.affiliation: Laboratoire de Biochimie, Hôpital Bichat-Claude Bernard, Assistance Publique-Hôpitaux de Paris-AP-HP, Paris, France.
authors.forename: Arnaud
authors.initials: A
authors.lastname: Bruneel
authors.forename: Monique
authors.initials: M
authors.lastname: Dehoux
authors.forename: Anne
authors.initials: A
authors.lastname: Barnier
authors.forename: Anne
authors.initials: A
authors.lastname: Boutten
mesh_terms: D001331:Automation / Q000295:instrumentation* / Q000592:standards; D001777:Blood Coagulation; D002097:C-Reactive Protein / Q000032:analysis; D019411:Clinical Laboratory Techniques / Q000295:instrumentation* / Q000379:methods* / Q000592:standards; D005337:Fibrin / Q000032:analysis / Q000378:metabolism; D006801:Humans; D057230:Limit of Detection; D008962:Models, Theoretical; D010783:Photometry / Q000295:instrumentation* / Q000592:standards; D015203:Reproducibility of Results; D018511:Systems Integration; D019210:Troponin I / Q000097:blood
chemical_list: D019210:Troponin I; D005337:Fibrin; D002097:C-Reactive Protein