title: Association of genetic variations in X-ray repair cross-complementing group 1 and Tourette syndrome.
abstract: BACKGROUND
  X-ray repair cross-complementing group 1 (XRCC1) plays a central role in mammalian DNA repair process. The polymorphism rs25487 (Arg>Gln at codon 399) of this gene is common in Han Chinese population.
  
  
  OBJECTIVE
  The objective of this study was to analyze the association between this functional SNP of XRCC1 and Tourette syndrome (TS) in Han Taiwan Chinese population.
  
  
  METHODS
  Genotyping was performed by using PCR-RFLP method on 73 TS patients and 158 normal controls.
  
  
  RESULTS
  Our data indicated that genotype frequency of A/G polymorphism at codon 399 of the patients differed from the controls (P = 0.026, OR: 2.22, 95% CI: 1.22-4.03). The allele frequency analysis also showed significant differences with higher A allele frequency in patients (P = 0.015, OR: 1.70, 95% CI: 1.11-2.62).
  
  
  CONCLUSIONS
  Our study indicates that the functional SNP at codon 399 of XRCC1 is associated with TS development.
authors.affiliation: Graduate Institute of Integrated Medicine, China Medical University, Taichung, Taiwan.
authors.forename: Wei-Yong
authors.initials: WY
authors.lastname: Lin
authors.forename: Cheng-Chun
authors.initials: CC
authors.lastname: Lee
authors.forename: Hsin-Ping
authors.initials: HP
authors.lastname: Liu
authors.forename: I-Ching
authors.initials: IC
authors.lastname: Chou
authors.forename: Jim Jinn-Chyuan
authors.initials: JJ
authors.lastname: Sheu
authors.forename: Lei
authors.initials: L
authors.lastname: Wan
authors.forename: Ying-Ju
authors.initials: YJ
authors.lastname: Lin
authors.forename: Yuhsin
authors.initials: Y
authors.lastname: Tsai
authors.forename: Fuu-Jen
authors.initials: FJ
authors.lastname: Tsai
mesh_terms: D044466:Asian People; D016009:Chi-Square Distribution; D002681:China; D004268:DNA-Binding Proteins / Q000235:genetics*; D056726:Genetic Association Studies; D005838:Genotype; D006801:Humans; D016017:Odds Ratio; D016133:Polymerase Chain Reaction; D012150:Polymorphism, Restriction Fragment Length; D020641:Polymorphism, Single Nucleotide; D005879:Tourette Syndrome / Q000235:genetics*; D000076105:X-ray Repair Cross Complementing Protein 1
chemical_list: D004268:DNA-Binding Proteins; D000076105:X-ray Repair Cross Complementing Protein 1; C000619371:XRCC1 protein, human