title: Small-molecule reprogramming of cancer metabolism.
abstract: Small molecules that inhibit common cancer-associated changes in metabolism have great potential as widely applicable therapies. In this issue of Chemistry & Biology, Kung et al. report the characterization of a small molecule activator of the enzyme pyruvate kinase M2, which reprograms cancer cell metabolism resulting in dependence on the amino acid serine.
authors.forename: Matthew R
authors.initials: MR
authors.lastname: Pratt