title: Administration of the phosphodiesterase type 4 inhibitor rolipram into the amygdala at a specific time interval after learning increases recognition memory persistence.
abstract: Here we show that administration of the phosphodiesterase type 4 (PDE4) inhibitor rolipram into the basolateral complex of the amygdala (BLA) at a specific time interval after training enhances memory consolidation and induces memory persistence for novel object recognition (NOR) in rats. Intra-BLA infusion of rolipram immediately, 1.5 h, or 6 h after training had no effect on retention tested at 1, 7, and 14 d later. However, rolipram infused 3 h post-training promoted memory persistence for up to at least 14 d. The findings suggest that PDE4 inhibition in the BLA can enhance long-term memory formation when induced specifically 3 h after learning.
authors.affiliation: Department of Pharmacology, Federal University of Rio Grande do Sul, Porto Alegre, RS, Brazil.
authors.forename: Aline
authors.initials: A
authors.lastname: Werenicz
authors.forename: Raissa R
authors.initials: RR
authors.lastname: Christoff
authors.forename: Martina
authors.initials: M
authors.lastname: Blank
authors.forename: Paulo F C
authors.initials: PF
authors.lastname: Jobim
authors.forename: Thiago R
authors.initials: TR
authors.lastname: Pedroso
authors.forename: Gustavo K
authors.initials: GK
authors.lastname: Reolon
authors.forename: Nadja
authors.initials: N
authors.lastname: Schröder
authors.forename: Rafael
authors.initials: R
authors.lastname: Roesler
mesh_terms: D000679:Amygdala / Q000187:drug effects* / Q000502:physiology; D000818:Animals; D016009:Chi-Square Distribution; D005106:Exploratory Behavior / Q000187:drug effects; D007858:Learning / Q000187:drug effects* / Q000502:physiology; D008297:Male; D058988:Phosphodiesterase 4 Inhibitors / Q000494:pharmacology*; D010775:Photic Stimulation; D051381:Rats; D017208:Rats, Wistar; D021641:Recognition, Psychology / Q000187:drug effects*; D012153:Retention, Psychology / Q000187:drug effects; D020889:Rolipram / Q000494:pharmacology*; D013997:Time Factors
chemical_list: D058988:Phosphodiesterase 4 Inhibitors; D020889:Rolipram