title: Glaucoma risk assessment using a non-linear multivariable regression method.
abstract: The present research investigates the relationship between the central corneal thickness (CCT), Heidelberg Retina Tomograph II (HRTII) structural measurements and intraocular pressure (IOP) using an innovative non-linear multivariable regression method in order to define the risk factors in future glaucoma development and patient management. The method is implemented to data from ninety-three open angle glaucoma eyes. The results show that in established glaucoma, CCT is significantly associated with HRTII structural measurements (maximum contour depression, cup volume inferotemporally) and IOP. They are also compared to those obtained from the application of standard linear regression methods, improving the coefficient determination R(2) by 35%, exhibiting thus the performance of the proposed methodology.
authors.affiliation: Department of Ophthalmology, 401 Hellenic Army General Hospital, 1 P. Kanellopoulou Avenue, 11525 Athens, Greece. d_kourkoutas@hotmail.gr
authors.forename: D
authors.initials: D
authors.lastname: Kourkoutas
authors.forename: I S
authors.initials: IS
authors.lastname: Karanasiou
authors.forename: G J
authors.initials: GJ
authors.lastname: Tsekouras
authors.forename: M
authors.initials: M
authors.lastname: Moshos
authors.forename: E
authors.initials: E
authors.lastname: Iliakis
authors.forename: G
authors.initials: G
authors.lastname: Georgopoulos
mesh_terms: D005901:Glaucoma / Q000503:physiopathology*; D006801:Humans; D008962:Models, Theoretical; D015999:Multivariate Analysis; D018570:Risk Assessment