title: Energy metabolism in cardiac remodeling and heart failure.
abstract: Fatty acids are the main substrates used by mitochondria to provide myocardial energy under normal conditions. During heart remodeling, however, the fuel preference switches to glucose. In the earlier stages of cardiac remodeling, changes in energy metabolism are considered crucial to protect the heart from irreversible damage. Furthermore, low fatty acid oxidation and the stimulus for glycolytic pathway lead to lipotoxicity, acidosis, and low adenosine triphosphate production. While myocardial function is directly associated with energy metabolism, the metabolic pathways could be potential targets for therapy in heart failure.
authors.affiliation: Internal Medicine Department, Botucatu Medical School, UNESP-São Paulo State University, CEP 18618-970, Sao Paulo, Brazil. paulasa@fmb.unesp.br
authors.forename: Paula S
authors.initials: PS
authors.lastname: Azevedo
authors.forename: Marcos F
authors.initials: MF
authors.lastname: Minicucci
authors.forename: Priscila P
authors.initials: PP
authors.lastname: Santos
authors.forename: Sergio A R
authors.initials: SA
authors.lastname: Paiva
authors.forename: Leonardo A M
authors.initials: LA
authors.lastname: Zornoff
mesh_terms: D000255:Adenosine Triphosphate / Q000096:biosynthesis / Q000378:metabolism; D002908:Chronic Disease; D004734:Energy Metabolism / Q000502:physiology*; D006321:Heart / Q000503:physiopathology*; D006333:Heart Failure / Q000378:metabolism* / Q000503:physiopathology; D006801:Humans; D008929:Mitochondria, Heart / Q000378:metabolism; D028361:Mitochondrial Diseases / Q000378:metabolism; D009206:Myocardium / Q000378:metabolism; D009569:Nitric Oxide / Q000502:physiology; D010084:Oxidation-Reduction
chemical_list: D009569:Nitric Oxide; D000255:Adenosine Triphosphate