title: Spirobacillenes A and B, unusual spiro-cyclopentenones from Lysinibacillus fusiformis KMC003.
abstract: Two previously unreported spiro-cyclopentenones, spirobacillenes A (1) and B (2), were isolated from the 24 h broth culture of Lysinibacillus fusiformis KMC003 derived from acidic coal-mine drainage. The structures of 1 and 2 were elucidated by analyses of the NMR, HRFABMS, single-crystal X-ray diffraction crystallography, and circular dichroism (CD) spectral data. Compound 1 possessed moderate inhibitory activity against the production of nitric oxide (NO) and reactive oxygen species (ROS).
authors.affiliation: Natural Medicine Center, Korea Institute of Science and Technology, Gangneung, Gangwon-do, Republic of Korea.
authors.forename: Hyun Bong
authors.initials: HB
authors.lastname: Park
authors.forename: Young-Joo
authors.initials: YJ
authors.lastname: Kim
authors.forename: Jae Kyun
authors.initials: JK
authors.lastname: Lee
authors.forename: Kang Ro
authors.initials: KR
authors.lastname: Lee
authors.forename: Hak Cheol
authors.initials: HC
authors.lastname: Kwon
mesh_terms: D000818:Animals; D001406:Bacillaceae / Q000737:chemistry*; D002460:Cell Line; D003517:Cyclopentanes / Q000737:chemistry* / Q000302:isolation & purification; D051379:Mice; D008958:Models, Molecular; D008968:Molecular Conformation; D009569:Nitric Oxide / Q000737:chemistry; D017382:Reactive Oxygen Species / Q000737:chemistry; D013141:Spiro Compounds / Q000737:chemistry* / Q000302:isolation & purification
chemical_list: D003517:Cyclopentanes; D017382:Reactive Oxygen Species; D013141:Spiro Compounds; C579583:spirobacillene A; C579584:spirobacillene B; D009569:Nitric Oxide