title: Carriage-associated Streptocccus pneumoniae serotype 1 in Brussels, Belgium.
abstract: Streptococcus pneumoniae serotype 1 presents a high invasiveness index and is seldom isolated from its niche, the nasopharynx. We report an unusual serotype 1 carriage in a healthy pediatric population at the time of the heptavalent pneumococcal vaccine adoption in Belgium. Our sampling period coincides with an epidemic wave of serotype 1 invasive pneumococcal infections. Invasive and colonizing isolates were characterized by both antibiotic resistance profile and multilocus sequence typing and were shown to share the same backbone (ST306 and ST350).
authors.affiliation: Laboratoire de Génétique et Physiologie Bactérienne, Institut de Biologie et de Médecine Moléculaires, Faculté des Sciences, Bruxelles, Belgium. sajourda@ulb.ac.be
authors.forename: Sarah
authors.initials: S
authors.lastname: Jourdain
authors.forename: Pierre-Alexandre
authors.initials: PA
authors.lastname: Drèze
authors.forename: Jan
authors.initials: J
authors.lastname: Verhaegen
authors.forename: Laurence
authors.initials: L
authors.lastname: Van Melderen
authors.forename: Pierre R
authors.initials: PR
authors.lastname: Smeesters
mesh_terms: D001530:Belgium / Q000453:epidemiology; D002353:Carrier State / Q000453:epidemiology / Q000382:microbiology*; D002648:Child; D002675:Child, Preschool; D058872:Epidemics; D000069443:Heptavalent Pneumococcal Conjugate Vaccine; D006801:Humans; D008826:Microbial Sensitivity Tests; D058885:Multilocus Sequence Typing; D011008:Pneumococcal Infections / Q000453:epidemiology / Q000382:microbiology*; D022242:Pneumococcal Vaccines; D011446:Prospective Studies; D012703:Serotyping; D013296:Streptococcus pneumoniae / Q000145:classification* / Q000187:drug effects / Q000302:isolation & purification
chemical_list: D000069443:Heptavalent Pneumococcal Conjugate Vaccine; D022242:Pneumococcal Vaccines