title: Association of HLA-DRB1*01 with Dupuytren's disease.
abstract: OBJECTIVE
  To explore the human leucocyte antigen (HLA)-DRB1 allele frequency in Dupuytren's disease (DD).
  
  
  METHODS
  HLA-DRB1 genotypes were analysed by sequence-specific primers (SSPs) in samples collected from 172 men participating in a nested case-control study on the clinical manifestations and progression of DD. Of those, 121 had signs of DD while 51 did not. Of the 121 men with DD, 49 had contracted fingers or had been operated on, while 72 had nodules or fibrous cords in the palms. Odds ratios (ORs) and 95% confidence interval (CIs) were used to evaluate the results.
  
  
  RESULTS
  The HLA-DRB1*01 allele was observed in 26 of the 121 affected men (23.7%) but in only four of the controls (7.8%) (OR 3.22, 95% CI 1.06-9.75). The HLA-DRB1*01 allele frequency in those affected was 11%, while in the control group it was 4% (OR 3.07, 95% CI 1.05-9.03).
  
  
  CONCLUSIONS
  This observation indicates a possible association of HLA-DRB1*01 with DD, but further studies are needed for confirmation.
authors.affiliation: The Blood Bank, Landspitali University Hospital, Reykjavík, Iceland.
authors.forename: T
authors.initials: T
authors.lastname: Jónsson
authors.forename: K G
authors.initials: KG
authors.lastname: Gudmundsson
authors.forename: K
authors.initials: K
authors.lastname: Bjarnadóttir
authors.forename: I B
authors.initials: IB
authors.lastname: Hjálmarsdótti
authors.forename: S
authors.initials: S
authors.lastname: Gudmundsson
authors.forename: R
authors.initials: R
authors.lastname: Arngrímsson
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D015331:Cohort Studies; D004387:Dupuytren Contracture / Q000453:epidemiology* / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease / Q000453:epidemiology / Q000235:genetics; D005838:Genotype; D059811:HLA-DRB1 Chains / Q000235:genetics*; D006306:Health Surveys; D006801:Humans; D007055:Iceland / Q000453:epidemiology; D008297:Male; D017678:Sex Distribution; D044465:White People / Q000235:genetics
chemical_list: D059811:HLA-DRB1 Chains; C497841:HLA-DRB1*01 antigen