title: Effects of periodontal therapy on disease activity and systemic inflammation in rheumatoid arthritis patients.
abstract: OBJECTIVE
  This observational prospective cohort study aimed to evaluate the effects of non-surgical periodontal treatment on clinical periodontal measurements and systemic inflammatory mediator levels in low or moderate to highly active rheumatoid arthritis (RA) patients with chronic periodontitis.
  
  
  METHODS
  Rheumatoid arthritis activity was assessed with disease activity score test (DAS28). Thirty patients with RA with moderate to high disease activity (DAS28 ≥ 3.2) and chronic periodontitis (MHDA group) and thirty patients with RA with low disease activity (DAS28 < 3.2) and chronic periodontitis (LDA group) were enrolled in the study. The patients were monitored at the beginning and 3 months after undergoing periodontal therapy. Erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), tumour necrosis factor-alpha (TNF-α) levels in serum, DAS28 and periodontal parameters were evaluated.
  
  
  RESULTS
  Erythrocyte sedimentation rate, CRP, TNF-α levels in serum, DAS28 and periodontal parameters exhibited similar and significant reduction 3 months after the non-surgical periodontal treatment.
  
  
  CONCLUSIONS
  Non-surgical periodontal treatment may prove beneficial in reducing RA severity as measured by ESR, CRP, TNF-α levels in serum and DAS28 in low or moderate to highly active RA patients with chronic periodontitis.
authors.affiliation: Department of Periodontology, Faculty of Dentistry, Gaziantep University, Gaziantep, Turkey.
authors.forename: K
authors.initials: K
authors.lastname: Erciyas
authors.forename: U
authors.initials: U
authors.lastname: Sezer
authors.forename: K
authors.initials: K
authors.lastname: Ustün
authors.forename: Y
authors.initials: Y
authors.lastname: Pehlivan
authors.forename: B
authors.initials: B
authors.lastname: Kisacik
authors.forename: S Z
authors.initials: SZ
authors.lastname: Senyurt
authors.forename: M
authors.initials: M
authors.lastname: Tarakçioğlu
authors.forename: A M
authors.initials: AM
authors.lastname: Onat
mesh_terms: D000328:Adult; D001172:Arthritis, Rheumatoid / Q000150:complications* / Q000628:therapy*; D001799:Blood Sedimentation; D002097:C-Reactive Protein / Q000032:analysis; D055113:Chronic Periodontitis / Q000150:complications* / Q000473:pathology / Q000628:therapy*; D015331:Cohort Studies; D012534:Dental Scaling; D005260:Female; D006801:Humans; D007249:Inflammation / Q000097:blood; D018836:Inflammation Mediators / Q000032:analysis; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D018709:Statistics, Nonparametric; D014409:Tumor Necrosis Factor-alpha / Q000097:blood
chemical_list: D018836:Inflammation Mediators; D014409:Tumor Necrosis Factor-alpha; D002097:C-Reactive Protein