title: Draft genome sequences of Helicobacter pylori isolates from Malaysia, cultured from patients with functional dyspepsia and gastric cancer.
abstract: Helicobacter pylori is the main bacterial causative agent of gastroduodenal disorders and a risk factor for gastric adenocarcinoma and mucosa-associated lymphoid tissue (MALT) lymphoma. The draft genomes of 10 closely related H. pylori isolates from the multiracial Malaysian population will provide an insight into the genetic diversity of isolates in Southeast Asia. These isolates were cultured from gastric biopsy samples from patients with functional dyspepsia and gastric cancer. The availability of this genomic information will provide an opportunity for examining the evolution and population structure of H. pylori isolates from Southeast Asia, where the East meets the West.
authors.affiliation: University of Malaya, Kuala Lumpur, Malaysia.
authors.forename: Selva Perumal
authors.initials: SP
authors.lastname: Gunaletchumy
authors.forename: Xinsheng
authors.initials: X
authors.lastname: Teh
authors.forename: Yalda
authors.initials: Y
authors.lastname: Khosravi
authors.forename: Nur Siti Khadijah
authors.initials: NS
authors.lastname: Ramli
authors.forename: Eng Guan
authors.initials: EG
authors.lastname: Chua
authors.forename: Thevakumar
authors.initials: T
authors.lastname: Kavitha
authors.forename: Joanne N
authors.initials: JN
authors.lastname: Mason
authors.forename: Huey Tyng
authors.initials: HT
authors.lastname: Lee
authors.forename: Halimah
authors.initials: H
authors.lastname: Alias
authors.forename: Nur Zafirah
authors.initials: NZ
authors.lastname: Zaidan
authors.forename: Norzawani Buang M
authors.initials: NB
authors.lastname: Yassin
authors.forename: Liang Chung
authors.initials: LC
authors.lastname: Tay
authors.forename: Stephen
authors.initials: S
authors.lastname: Rudd
authors.forename: Hazel M
authors.initials: HM
authors.lastname: Mitchell
authors.forename: Nadeem O
authors.initials: NO
authors.lastname: Kaakoush
authors.forename: Mun Fai
authors.initials: MF
authors.lastname: Loke
authors.forename: Khean Lee
authors.initials: KL
authors.lastname: Goh
authors.forename: Jamuna
authors.initials: J
authors.lastname: Vadivelu
mesh_terms: D001706:Biopsy; D004269:DNA, Bacterial / Q000737:chemistry* / Q000235:genetics*; D004415:Dyspepsia / Q000382:microbiology; D016680:Genome, Bacterial; D016481:Helicobacter Infections / Q000382:microbiology; D016480:Helicobacter pylori / Q000235:genetics* / Q000302:isolation & purification; D006801:Humans; D008296:Malaysia; D008969:Molecular Sequence Data; D017422:Sequence Analysis, DNA; D013274:Stomach Neoplasms / Q000382:microbiology
chemical_list: D004269:DNA, Bacterial