title: Evaluation of immunostimulatory activities of synthetic mannose-containing structures mimicking the β-(1->2)-linked cell wall mannans of Candida albicans.
abstract: Immunostimulatory properties of synthetic structures mimicking the β-(1→2)-linked mannans of Candida albicans were evaluated in vitro. Contrary to earlier observations, tumor necrosis factor (TNF) production was not detected after stimulation with mannotetraose in mouse macrophages. Divalent disaccharide 1,4-bis(α-D-mannopyranosyloxy)butane induced TNF and some molecules induced low levels of gamma interferon (IFN-γ) in human peripheral blood mononuclear cells (PBMC).
authors.affiliation: Department of Pulmonary Diseases and Clinical Allergology, University of Turku, Turku, Finland.
authors.forename: Kaarina
authors.initials: K
authors.lastname: Ranta
authors.forename: Kaisa
authors.initials: K
authors.lastname: Nieminen
authors.forename: Filip S
authors.initials: FS
authors.lastname: Ekholm
authors.forename: Moniká
authors.initials: M
authors.lastname: Poláková
authors.forename: Mattias U
authors.initials: MU
authors.lastname: Roslund
authors.forename: Tiina
authors.initials: T
authors.lastname: Saloranta
authors.forename: Reko
authors.initials: R
authors.lastname: Leino
authors.forename: Johannes
authors.initials: J
authors.lastname: Savolainen
mesh_terms: D000818:Animals; D002176:Candida albicans / Q000737:chemistry* / Q000276:immunology*; D002478:Cells, Cultured; D006801:Humans; D007371:Interferon-gamma / Q000378:metabolism; D007963:Leukocytes, Mononuclear / Q000276:immunology; D008264:Macrophages / Q000276:immunology; D008351:Mannans / Q000138:chemical synthesis* / Q000276:immunology*; D051379:Mice; D008807:Mice, Inbred BALB C; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism
chemical_list: D008351:Mannans; D014409:Tumor Necrosis Factor-alpha; D007371:Interferon-gamma