title: Differential neural network of checking versus washing symptoms in obsessive-compulsive disorder.
abstract: Obsessive-compulsive disorder (OCD) is clinically heterogeneous. The aim of this study was to investigate differential neural responses to a symptom provocation task in drug-free patients who have predominantly aggression/checking symptoms (Checkers) and patients with contamination/washing symptoms (Washers). We compared the Checkers (n=10) and the Washers (n=12) separately to normal controls during the symptom provocation tasks using fMRI (functional magnetic resonance imaging). Moreover, we performed correlative analysis in each OCD group between brain activation and symptom severity. The Checkers showed hypoactivation in the left caudate and left anterior cingulate cortex (ACC) compared to the normal controls and a positive correlation between activated brain areas and symptom severity in the left ACC. The Washers showed hyperactivation in several bilateral cortico-cerebellar regions and a positive correlation between symptom severity and the bilateral fronto-temporal gyrus. We suggest that the caudate and ACC are associated with checking rituals and that large cortical brain regions are related to washing rituals.
authors.affiliation: Department of Neuropsychiatry, Graduate School of Medical Science, Kyushu University, Fukuoka, Japan.
authors.forename: Keitaro
authors.initials: K
authors.lastname: Murayama
authors.forename: Tomohiro
authors.initials: T
authors.lastname: Nakao
authors.forename: Hirokuni
authors.initials: H
authors.lastname: Sanematsu
authors.forename: Kayo
authors.initials: K
authors.lastname: Okada
authors.forename: Takashi
authors.initials: T
authors.lastname: Yoshiura
authors.forename: Mayumi
authors.initials: M
authors.lastname: Tomita
authors.forename: Yusuke
authors.initials: Y
authors.lastname: Masuda
authors.forename: Kayoko
authors.initials: K
authors.lastname: Isomura
authors.forename: Akiko
authors.initials: A
authors.lastname: Nakagawa
authors.forename: Shigenobu
authors.initials: S
authors.lastname: Kanba
mesh_terms: D000293:Adolescent; D000328:Adult; D001921:Brain / Q000503:physiopathology*; D001931:Brain Mapping; D003192:Compulsive Behavior / Q000503:physiopathology* / Q000523:psychology; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009770:Obsessive Behavior / Q000503:physiopathology* / Q000523:psychology; D009771:Obsessive-Compulsive Disorder / Q000503:physiopathology* / Q000523:psychology; D010524:Peripheral Nervous System Neoplasms / Q000503:physiopathology*