title: [Complex chromosome damages in patients with recurrent acute leukemias after allogeneic hematopoietic stem cell transplantations].
abstract: OBJECTIVE
  To study the pattern of complex chromosome damages (CCD) in acute leukemias (AL) and their place in the development of post-transplant recurrences (PTR) of AL.
  
  
  METHODS
  Cytogenetic and partially molecular biological studies of bone marrow cells were conducted in 10 patients with PTR. Of them, 6 patients were diagnosed as having acute lymphoblastic leukemia (ALL), including T-ALL and Ph-positive ALL in 2 and 4 patients, respectively; and 4 patients had acute non-lymphoblastic leukemia (ANLL), including one case secondarily induced by previous polychemotherapy (PCT) and irradiation. The standard G-band staining technique complemented by multicolor fluorescence in situ hybridization in one of the cases was used.
  
  
  RESULTS
  It was shown that CCD had the similar pattern in 4 patients before transplantation and in PTR, progressed in 4 more patients, was absent or unnoticed in the early stage of the disease. The other recurrent chromosomal abnormalities that are worthy of notice are as follows: a) the presence of two Ph chromosomes in the cells of two of the 4 patients with Ph+ ALL; b) the frequent involvement of chromosome pairs 9, 19, 5, and 7 into the numerical and structural rearrangements.
  
  
  CONCLUSIONS
  The important feature of PTR of AL is cellular CCDs, a portion of which is clearly related to previous PCT and may be of pathogenetic value for the development of recurrences.
authors.forename: T L
authors.initials: TL
authors.lastname: Gindina
authors.forename: N N
authors.initials: NN
authors.lastname: Mamaev
authors.forename: I M
authors.initials: IM
authors.lastname: Barkhatov
authors.forename: I S
authors.initials: IS
authors.lastname: Solomonova
authors.forename: E V
authors.initials: EV
authors.lastname: Semenova
authors.forename: L S
authors.initials: LS
authors.lastname: Zubarovskaia
authors.forename: E V
authors.initials: EV
authors.lastname: Morozova
authors.forename: Iu V
authors.initials: IuV
authors.lastname: Rudnitskaia
authors.forename: M A
authors.initials: MA
authors.lastname: Popova
authors.forename: S M
authors.initials: SM
authors.lastname: Alekseev
mesh_terms: D000208:Acute Disease / Q000628:therapy*; D000293:Adolescent; D000328:Adult; D002869:Chromosome Aberrations; D005260:Female; D018380:Hematopoietic Stem Cell Transplantation / Q000009:adverse effects*; D006801:Humans; D007938:Leukemia / Q000235:genetics / Q000628:therapy*; D007945:Leukemia, Lymphoid / Q000235:genetics / Q000628:therapy; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local; D014184:Transplantation, Homologous / Q000009:adverse effects*; D055815:Young Adult