title: Two cases of localized neuroblastoma with multiple segmental chromosomal alterations and metastatic progression.
abstract: Surgery alone is curative for most children with localized MYCN-non-amplified neuroblastoma. However, 10-15% will develop recurrent loco-regional disease, and very rarely, patients will relapse metastatically. Currently, it is not possible to predict which child with localized, MYCN-non-amplified neuroblastoma will develop disseminated disease. We report two children who presented with favorable biology, localized neuroblastoma and subsequently relapsed with metastatic disease after treatment with surgery. Whole-genome DNA copy number analyses performed on the diagnostic tumors identified 15 (case 1) and 8 (case 2) segmental chromosomal alterations. Further analysis of the prognostic value of whole-genome analysis in children with localized neuroblastoma is warranted.
authors.affiliation: Department of Neuro-Oncology, Dana Farber Cancer Institute/Boston Children's Hospital, Boston, Massachusetts, USA.
authors.forename: Andres
authors.initials: A
authors.lastname: Morales La Madrid
authors.forename: Melanie Beglin
authors.initials: MB
authors.lastname: Nall
authors.forename: Karen
authors.initials: K
authors.lastname: Ouyang
authors.forename: Agata
authors.initials: A
authors.lastname: Minor
authors.forename: Gordana
authors.initials: G
authors.lastname: Raca
authors.forename: Paul
authors.initials: P
authors.lastname: Kent
authors.forename: Ira
authors.initials: I
authors.lastname: Miller
authors.forename: Gudrun
authors.initials: G
authors.lastname: Schleiermacher
authors.forename: Isabelle
authors.initials: I
authors.lastname: Janoueix-Lerosey
authors.forename: Susan L
authors.initials: SL
authors.lastname: Cohn
mesh_terms: D002675:Child, Preschool; D002869:Chromosome Aberrations; D056915:DNA Copy Number Variations; D018450:Disease Progression; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D007223:Infant; D008297:Male; D009361:Neoplasm Invasiveness / Q000235:genetics / Q000473:pathology; D009362:Neoplasm Metastasis / Q000235:genetics / Q000473:pathology; D009447:Neuroblastoma / Q000235:genetics* / Q000473:pathology*; D020411:Oligonucleotide Array Sequence Analysis; D020641:Polymorphism, Single Nucleotide