title: Weight loss and vascular inflammatory markers in overweight women with and without polycystic ovary syndrome.
abstract: Polycystic ovary syndrome (PCOS) is associated with increased cardiovascular disease risk. The effect of weight loss on the vascular inflammatory markers plasminogen activator inhibitor-1 (PAI-1), asymmetric dimethylarginine (ADMA), soluble vascular cell adhesion molecule-1 (sVCAM-1) and intracellular adhesion molecule-1 (sICAM-1) is unknown. Overweight women with (n=14) and without (n=13) PCOS of comparable age and body mass index undertook an 8-week weight-loss programme. Women with PCOS had elevated PAI-1, sVCAM-1 and sICAM-1 before and after weight loss compared with the controls. For all women, sVCAM-1 (P=0.026) and sICAM-1 (P=0.04) decreased with weight loss. Women with PCOS have elevated inflammatory markers, which are partially reduced by weight loss.
authors.affiliation: The Robinson Institute, University of Adelaide, 55 King William Road, North Adelaide, 5006 South Australia, Australia. lisa.moran@adelaide.edu.au
authors.forename: Lisa J
authors.initials: LJ
authors.lastname: Moran
authors.forename: Manny
authors.initials: M
authors.lastname: Noakes
authors.forename: Gary A
authors.initials: GA
authors.lastname: Wittert
authors.forename: Peter M
authors.initials: PM
authors.lastname: Clifton
authors.forename: Robert J
authors.initials: RJ
authors.lastname: Norman
mesh_terms: D000328:Adult; D001120:Arginine / Q000031:analogs & derivatives / Q000235:genetics / Q000378:metabolism; D015415:Biomarkers / Q000378:metabolism; D002318:Cardiovascular Diseases / Q000150:complications / Q000235:genetics*; D005260:Female; D006801:Humans; D018799:Intercellular Adhesion Molecule-1 / Q000235:genetics / Q000378:metabolism; D017395:Plasminogen Activator Inhibitor 1 / Q000235:genetics / Q000378:metabolism; D011085:Polycystic Ovary Syndrome / Q000150:complications / Q000378:metabolism*; D019010:Vascular Cell Adhesion Molecule-1 / Q000235:genetics / Q000378:metabolism; D055105:Waist Circumference; D015431:Weight Loss
chemical_list: D015415:Biomarkers; D017395:Plasminogen Activator Inhibitor 1; C051321:SERPINE1 protein, human; D019010:Vascular Cell Adhesion Molecule-1; D018799:Intercellular Adhesion Molecule-1; C018524:N,N-dimethylarginine; D001120:Arginine