title: [Efficiency of use of autologous activated serum in coxarthrosis].
abstract: OBJECTIVE
  To evaluate the clinical efficiency of using autologous conditioned (activated) serum (ACS) versus hyaluronic acid (HA) in coxarthrosis (CA).
  
  
  METHODS
  Two groups of patients (n = 54) who were matched for age, sex, and disease duration and had a valid diagnosis of CA were examined. During 3 weeks, Groups 1 and 2 patients received intra-articular therapy with ACS or synocrome forte (Croma Pharma, Sotex), respectively, for 3 weeks. A 12-month follow-up evaluated the magnitude of pain, by using the visual analog scale (VAS, mm), the functional index WOMAC and general health, by applying the EQ-VAS scale.
  
  
  RESULTS
  The only benefit of HA was found to be more functional improvement as detected by the WOMAC index (-21.8%; t = 2.56) at an early (1-month) follow-up. After 3 months, the patients in the ACS group were recorded to have the maximum VAS pain intensity reduction that was 76.5% greater than that (t = 4.31) in the HA group. The clearest advantages of ACS therapy were traced 6 months after treatment.
  
  
  CONCLUSIONS
  The use of ACS may be a real alternative to that of HA derivatives in achieving good clinical outcomes in patients with CA. After ACS administration, there was a long-term preservation of achieved positive results.
authors.forename: S M
authors.initials: SM
authors.lastname: Noskov
authors.forename: L Iu
authors.initials: LIu
authors.lastname: Shirokova
authors.forename: A V
authors.initials: AV
authors.lastname: Snigireva
authors.forename: O M
authors.initials: OM
authors.lastname: Parulia
authors.forename: S D
authors.initials: SD
authors.lastname: Dybin
mesh_terms: D000368:Aged; D005260:Female; D006801:Humans; D006820:Hyaluronic Acid / Q000008:administration & dosage*; D007270:Injections, Intra-Articular; D008297:Male; D008875:Middle Aged; D015207:Osteoarthritis, Hip / Q000097:blood / Q000628:therapy*; D044967:Serum; D012720:Severity of Illness Index; D016896:Treatment Outcome; D055675:Viscosupplements / Q000008:administration & dosage* / Q000097:blood
chemical_list: D055675:Viscosupplements; D006820:Hyaluronic Acid