title: Emergence of multiresistant methicillin-resistant Staphylococcus aureus in two patients with atopic dermatitis requiring linezolid treatment.
abstract: We report two patients with atopic dermatitis who developed methicillin-resistant Staphylococcus aureus (MRSA) skin infections resistant to clindamycin and trimethoprim-sulfamethoxazole requiring repeated linezolid treatment. For one patient and family members who received an aggressive regimen of staphylococcal decolonization, including intranasal mupirocin, dilute bleach baths, and bleach cleansing of household items and surfaces, subsequent culture results demonstrated methicillin-susceptible S. aureus colonization and infection. These findings underscore the challenges presented by multiresistant MRSA infections in children with atopic dermatitis.
authors.affiliation: Department of Pediatrics, Children's Hospital Los Angeles, Los Angeles, California.
authors.forename: Jaime S
authors.initials: JS
authors.lastname: Rosa
authors.forename: Lawrence A
authors.initials: LA
authors.lastname: Ross
authors.forename: Peck Y
authors.initials: PY
authors.lastname: Ong
mesh_terms: D000081:Acetamides / Q000627:therapeutic use*; D000890:Anti-Infective Agents / Q000627:therapeutic use*; D003876:Dermatitis, Atopic / Q000188:drug therapy* / Q000382:microbiology*; D005260:Female; D006801:Humans; D007223:Infant; D000069349:Linezolid; D008297:Male; D055624:Methicillin-Resistant Staphylococcus aureus; D023303:Oxazolidinones / Q000627:therapeutic use*; D013207:Staphylococcal Skin Infections / Q000188:drug therapy* / Q000382:microbiology*
chemical_list: D000081:Acetamides; D000890:Anti-Infective Agents; D023303:Oxazolidinones; D000069349:Linezolid