title: Diabetes mellitus and myocardial mitochondrial dysfunction: bench to bedside.
abstract: In diabetics, the risk for development of heart failure is increased even after adjusting for coronary artery disease and hypertension. Although the cause of this increased heart failure risk is multifactorial, increasing evidence suggests that dysfunction of myocardial mitochondria represents an important pathogenetic factor. To date, no specific therapy exists to treat mitochondrial function in any cardiac disease. This article presents underlying mechanisms of mitochondrial dysfunction in the diabetic heart and discusses potential therapeutic options that may attenuate these mitochondrial derangements.
authors.affiliation: Department of Cardiology and Angiology, University Hospital of Freiburg, Hugstetter Strasse 55, Freiburg, Germany.
authors.forename: Alexandra
authors.initials: A
authors.lastname: König
authors.forename: Christoph
authors.initials: C
authors.lastname: Bode
authors.forename: Heiko
authors.initials: H
authors.lastname: Bugger
mesh_terms: D000975:Antioxidants / Q000627:therapeutic use; D003924:Diabetes Mellitus, Type 2 / Q000150:complications* / Q000188:drug therapy / Q000473:pathology; D006333:Heart Failure / Q000188:drug therapy / Q000209:etiology*; D006801:Humans; D008928:Mitochondria / Q000378:metabolism / Q000473:pathology; D028361:Mitochondrial Diseases / Q000150:complications* / Q000188:drug therapy / Q000473:pathology; D009206:Myocardium / Q000378:metabolism / Q000473:pathology*; D018384:Oxidative Stress; D018570:Risk Assessment / Q000379:methods
chemical_list: D000975:Antioxidants