title: Analogues of the epoxy resin monomer diglycidyl ether of bisphenol F: effects on contact allergenic potency and cytotoxicity.
abstract: Diglycidyl ethers of bisphenol A (DGEBA) and bisphenol F (DGEBF) are widely used as components in epoxy resin thermosetting products. They are known to cause occupational and nonoccupational allergic contact dermatitis. The aim of this study is to investigate analogues of DGEBF with regard to contact allergy and cytotoxicity. A comprehensive knowledge of the structural features that contribute to the allergenic and cytotoxic effects of DGEBF will guide the development of future novel epoxy resin systems with reduced health hazards for those coming into contact with them. It was found that the allergenic effects of DGEBF were dependent on its terminal epoxide groups. In contrast, it was found that the cytotoxicity in monolayer cell culture was dependent not only on the presence of epoxide groups but also on other structural features.
authors.affiliation: Department of Chemistry and Molecular Biology, Dermatochemistry and Skin Allergy, University of Gothenburg, SE-412 96 Gothenburg, Sweden. oboyleni@tcd.ie
authors.forename: Niamh M
authors.initials: NM
authors.lastname: O'Boyle
authors.forename: Tamara
authors.initials: T
authors.lastname: Delaine
authors.forename: Kristina
authors.initials: K
authors.lastname: Luthman
authors.forename: Andreas
authors.initials: A
authors.lastname: Natsch
authors.forename: Ann-Therese
authors.initials: AT
authors.lastname: Karlberg
mesh_terms: D000818:Animals; D001559:Benzhydryl Compounds / Q000737:chemistry / Q000494:pharmacology* / Q000633:toxicity*; D002470:Cell Survival / Q000187:drug effects; D017449:Dermatitis, Allergic Contact; D004305:Dose-Response Relationship, Drug; D004852:Epoxy Compounds / Q000737:chemistry / Q000494:pharmacology* / Q000633:toxicity*; D004853:Epoxy Resins / Q000737:chemistry / Q000494:pharmacology* / Q000633:toxicity*; D005260:Female; D051379:Mice; D008808:Mice, Inbred CBA; D015394:Molecular Structure; D023422:Skin Irritancy Tests; D013329:Structure-Activity Relationship
chemical_list: D001559:Benzhydryl Compounds; D004852:Epoxy Compounds; D004853:Epoxy Resins; C423722:bisphenol F diglycidyl ether