title: Midline brain-in-brain malformation associated with bilateral perirolandic cortical abnormalities: an image review of this rare disorder.
abstract: A midline brain-in-brain malformation was recently reported, but appropriate classification of this malformation remains uncertain. We describe a child with a complex brain malformation that was not restricted to the midline structures, enlarging the neuroanatomical spectrum of this pseudotumoral midline dysplasia associated with corpus callosum dysgenesis, azygos anterior cerebral artery, absent septum pellucidum and bilateral perirolandic cortical abnormalities. The spectrum of fusion of the cerebral hemispheres and associated brain hemispherical abnormalities is not completely understood. Our data are in line with previous arguments that this malformation could be an additional variant in the spectrum of holoprosencephaly.
authors.affiliation: Division of Neuroradiology, Santa Casa de Misericórdia de São Paulo, Serviço de Diagnóstico por Imagem, Rua Dr. Cesário Motta Junior 61, Vila Buarque, São Paulo, Brazil, 01221-020. a.rocha@uol.com.br
authors.forename: Antonio José
authors.initials: AJ
authors.lastname: da Rocha
authors.forename: Pedro José
authors.initials: PJ
authors.lastname: Santana
authors.forename: Antonio Carlos Martins
authors.initials: AC
authors.lastname: Maia
mesh_terms: D000015:Abnormalities, Multiple / Q000473:pathology*; D001921:Brain / Q000002:abnormalities* / Q000473:pathology*; D002648:Child; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male