title: Life-threatening agranulocytosis, anemia, and plasmacytosis after dipyrone use for fever in a child.
abstract: Dipyrone or metamizole Na (Novalgin) is commonly used as an antipyretic, analgesic, and spasmolytic agent in some parts of the world; however, it is banned in developed countries because of severe side effects. Here we present a case of a 4-year-old boy who developed life-threatening agranulocytosis, anemia, and marked plasmacytosis in his bone marrow after dipyrone use for fever, which resolved with steroid therapy.
authors.affiliation: *Department of Pediatric Hematology †Pediatrics Infectious Diseases Units of the Department of Pediatrics; Medical School of Gazi University, Ankara, Turkey.
authors.forename: Melek
authors.initials: M
authors.lastname: Işık
authors.forename: Zuhre
authors.initials: Z
authors.lastname: Kaya
authors.forename: Fatma Burcu
authors.initials: FB
authors.lastname: Belen
authors.forename: Anıl Tapısız
authors.initials: AT
authors.lastname: Aktaş
authors.forename: Hasan
authors.initials: H
authors.lastname: Tezer
authors.forename: Türkiz
authors.initials: T
authors.lastname: Gürsel
mesh_terms: D000208:Acute Disease; D000380:Agranulocytosis / Q000139:chemically induced*; D000740:Anemia / Q000139:chemically induced*; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects; D002675:Child, Preschool; D004177:Dipyrone / Q000009:adverse effects*; D005334:Fever / Q000188:drug therapy*; D006801:Humans; D008297:Male; D010950:Plasma Cells / Q000187:drug effects / Q000473:pathology*
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D004177:Dipyrone