title: Sublocalization of Rab23, a mediator of Sonic hedgehog signaling pathway,             in hepatocellular carcinoma cell lines.
abstract: The novel member of the Rab family of GTPases, Rab23, is an essential negative             regulator of the Sonic hedgehog (Shh) signaling pathway. Loss of function mutation             of the Rab23 gene causes abnormal development of the neural tube in mice and in             certain human congenital diseases. The aberrant overexpression of Rab23 has been             associated with various diseases, such as gastric, hepatocellular and lung cancer.             The exact function of Rab23 in hepatocellular carcinomas (HCCs), however, remains             unknown. Previously, we reported the abnormal sublocalization of Rab23 in lung             cancers. In the current study, we investigated the role of Rab23 in HCCs. We report             the distinct sublocalization pattern of Rab23 in HCC cell lines. This difference             depends on the GDP/GTP-binding form, and inhibition of the Rab23 cycle decreases             the expression and nuclear localization of Gli1.
authors.affiliation: Department of Neurobiology, Shandong Provincial Key Laboratory                     of Mental Disorders, School of Medicine, Shandong University, Jinan, Shandong,                     P.R. China.
authors.forename: Hai-Ji
authors.initials: HJ
authors.lastname: Sun
authors.forename: Yun-Jian
authors.initials: YJ
authors.lastname: Liu
authors.forename: Na
authors.initials: N
authors.lastname: Li
authors.forename: Zhi-Yong
authors.initials: ZY
authors.lastname: Sun
authors.forename: Hai-Wang
authors.initials: HW
authors.lastname: Zhao
authors.forename: Chen
authors.initials: C
authors.lastname: Wang
authors.forename: Hui
authors.initials: H
authors.lastname: Li
authors.forename: Fang-Ming
authors.initials: FM
authors.lastname: Ma
authors.forename: Song-Mei
authors.initials: SM
authors.lastname: Shi
authors.forename: Xiao-Qiu
authors.initials: XQ
authors.lastname: Xu
authors.forename: Zhe-Yu
authors.initials: ZY
authors.lastname: Chen
authors.forename: Shu-Hong
authors.initials: SH
authors.lastname: Huang
mesh_terms: D006528:Carcinoma, Hepatocellular / Q000378:metabolism / Q000473:pathology; D045744:Cell Line, Tumor; D002467:Cell Nucleus / Q000378:metabolism; D053823:Hedgehog Proteins / Q000378:metabolism*; D056945:Hep G2 Cells; D006801:Humans; D008113:Liver Neoplasms / Q000378:metabolism / Q000473:pathology; D018613:Microscopy, Confocal; D009154:Mutation; D034622:RNA Interference; D034741:RNA, Small Interfering / Q000378:metabolism; D015398:Signal Transduction; D014157:Transcription Factors / Q000037:antagonists & inhibitors / Q000235:genetics / Q000378:metabolism; D000071676:Zinc Finger Protein GLI1; D020691:rab GTP-Binding Proteins / Q000032:analysis* / Q000037:antagonists & inhibitors / Q000378:metabolism
chemical_list: C400551:GLI1 protein, human; D053823:Hedgehog Proteins; D034741:RNA, Small Interfering; D014157:Transcription Factors; D000071676:Zinc Finger Protein GLI1; C486614:RAB23 protein, human; D020691:rab GTP-Binding Proteins