title: Assessment of the impact of malaria on CD4+ T Cells and haemoglobin levels of HIV-malaria co-infected patients.
abstract: BACKGROUND
  The human immunodeficiency virus (HIV) and malaria destroy important cells required for proper immunological and haematological functioning of the body. This research therefore aimed to assess the effect of malaria on CD4+ and haemoglobin (Hb) levels of HIV-malaria co-infected patients.
  
  
  METHODS
  The study was performed by sampling 220 adult HIV patients on highly active anti retroviral therapy (HAART) who routinely visited the Tema General Hospital in Ghana. Blood samples were obtained for both blood film microscopy identification of malaria parasites and analysis using rapid diagnostic test kits. A BD Facscount Analyzer was used in the quantification of CD4+ levels.
  
  
  RESULTS
  Of the 220 patients sampled, 34 (15.5%) were HIV-malaria co-infected, all of whom (34; 100%) had CD4+ counts below the normal range, while 23 (12.9%) of the HIV mono-infected patients had normal CD4+ counts. Almost all HIV-malaria co-infected patients (33; 97.1%) had low Hb levels, whereas 79 (42.5%) of the HIV mono-infected patients had normal Hb. Malaria infection strongly correlated positively and significantly with both low CD4+ count (χ2 = 0.828, P = 0.003) and Hb (χ2 = 0.817, P = 0.004) levels.
  
  
  CONCLUSIONS
  Malaria co-infection with HIV decreases CD4+ T cells and Hb levels in patients. It is therefore recommended that HIV patients in malaria endemic areas should adhere to malaria preventive measures.
authors.affiliation: University of Cape Coast, Ghana. dnatagoe@gmail.com
authors.forename: Daniel Nii Aryee
authors.initials: DN
authors.lastname: Tagoe
authors.forename: Joseph
authors.initials: J
authors.lastname: Boachie
mesh_terms: D000328:Adult; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology*; D060085:Coinfection / Q000276:immunology / Q000473:pathology*; D005260:Female; D005869:Ghana; D015658:HIV Infections / Q000150:complications* / Q000276:immunology / Q000473:pathology*; D006454:Hemoglobins / Q000032:analysis*; D006801:Humans; D008288:Malaria / Q000150:complications* / Q000276:immunology / Q000473:pathology*; D008297:Male
chemical_list: D006454:Hemoglobins