title: Proinflammatory cytokine IL-1 β polymorphisms in sudden sensorineural hearing loss.
abstract: The cause and pathogenesis of sudden sensorineural hearing loss (SSNHL) remain unknown. IL-1β is one of the most powerful inflammatory cytokines. The aim of this study was to evaluate the relationships between interleukin-1 β (IL-1β) gene polymorphisms (-511 C/T and +3953 C/T) in patients with SSNHL. One hundred two patients affected by SSNHL and 595 controls were genotyped for IL-1β gene polymorphisms. The polymorphisms were analyzed by polymerase chain reaction amplification and DNA fragment separation via electrophoresis. Compared to controls, the IL-1β (+3953) T allele increased the relative risk of SSNHL in subjects with IL-1β (-511) TT genotype (p = 0.022, OR = 9.111, 95% CI = 1.441-57.618). In this study, polymorphisms in the IL-1β -511 and IL-1β +3953 loci were assessed for evidence of association with SSNHL. From this assessment, a significant difference in carriage of both the IL-1β -511 T allele and the IL-1β +3953 T allele was observed between SSNHL and controls. This suggests that the IL-1β -511 and +3953 loci may play an important role in the etiopathogenesis of SSNHL.
authors.affiliation: College of Korean Medicine, Institute of Korean Medicine, Kyung Hee University, 1 Heogi-dong, Dongdaemun-gu, Seoul, Republic of Korea. jyum@khu.ac.kr
authors.forename: Jae-Young
authors.initials: JY
authors.lastname: Um
authors.forename: Chul-Ho
authors.initials: CH
authors.lastname: Jang
authors.forename: Hye-Lin
authors.initials: HL
authors.lastname: Kim
authors.forename: Young-Bum
authors.initials: YB
authors.lastname: Cho
authors.forename: Jinbong
authors.initials: J
authors.lastname: Park
authors.forename: Seung Joo
authors.initials: SJ
authors.lastname: Lee
authors.forename: Yoon Bum
authors.initials: YB
authors.lastname: Kim
authors.forename: Hyun-Ju
authors.initials: HJ
authors.lastname: Kim
authors.forename: Kwang Seok
authors.initials: KS
authors.lastname: Ahn
authors.forename: Hyeung-Jin
authors.initials: HJ
authors.lastname: Jang
authors.forename: Seok-Geun
authors.initials: SG
authors.lastname: Lee
authors.forename: Hyejung
authors.initials: H
authors.lastname: Lee
authors.forename: Kang-Min
authors.initials: KM
authors.lastname: Lee
authors.forename: Su-Jin
authors.initials: SJ
authors.lastname: Kim
authors.forename: Seung-Heon
authors.initials: SH
authors.lastname: Hong
mesh_terms: D000483:Alleles; D005260:Female; D005838:Genotype; D006319:Hearing Loss, Sensorineural / Q000235:genetics* / Q000276:immunology; D003639:Hearing Loss, Sudden / Q000235:genetics* / Q000276:immunology; D006801:Humans; D053583:Interleukin-1beta / Q000235:genetics* / Q000276:immunology; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic
chemical_list: D053583:Interleukin-1beta