title: A new bergenin derivative from the rhizome of Ardisia gigantifolia.
abstract: One new bergenin derivative, named 11-O-veratroylbergenin (1) along with five known bergenin derivatives, 11-O-(3'-O-methylgalloyl) bergenin (2), 11-O-syringylbergenin (3), 11-O-Galloylbergenin (4), 4-O-Galloylbergenin (5) and bergenin (6) were isolated from Ardisia gigantifolia Stapf. Their structures were established on the basis of spectroscopic analysis, especially by means of 1D, 2D-NMR and HR-ESIMS analyses. Compounds 2, 4 and 5 showed significant 2,2-diphenyl-1-picrylhydrazyl (DPPH) free-radical scavenging activity with EC₅₀ 9.7, 9.0 and 7.8 µmol L(-1), respectively. They showed more antioxidant activity than the positive control vitamin C (EC₅₀ = 28.3 µmol L(-1)).
authors.affiliation: Department of Clinical Pharmacology, General Hospital of People's Liberation Army, Beijing 100853, PR China.
authors.forename: Li-Hua
authors.initials: LH
authors.lastname: Mu
authors.forename: Ju-Qiang
authors.initials: JQ
authors.lastname: Feng
authors.forename: Ping
authors.initials: P
authors.lastname: Liu
mesh_terms: D031644:Ardisia / Q000737:chemistry*; D001205:Ascorbic Acid; D001578:Benzopyrans / Q000737:chemistry / Q000302:isolation & purification* / Q000378:metabolism*; D016166:Free Radical Scavengers / Q000378:metabolism*; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D015394:Molecular Structure; D010936:Plant Extracts / Q000737:chemistry*; D027343:Rhizome / Q000737:chemistry*
chemical_list: D001578:Benzopyrans; D016166:Free Radical Scavengers; D010936:Plant Extracts; C006741:bergenin; D001205:Ascorbic Acid