title: Out with the old, in with the new? Case reports of the clinical features and acute management of two novel designer drugs.
abstract: Methoxydine (4-MeO-PCP) and Methoxetamine (3-MeO-2-Oxo-PCE) are both commercially produced designer drugs with structural and biochemical similarities to phencyclidine (PCP). Although phencyclidine toxicity is well documented, its recreational use in present times is rare. With the advent of new designer drugs being available widely through internet sites, Acute Physicians should be aware of the clinical features and management of these potential toxins. We present a case of methoxydine ingestion (which to our knowledge has not been previously documented in any medical journals) and a case of methoxetamine ingestion, and discuss their history, contrasting clinical features and acute management.
authors.affiliation: Acute Medicine Unit Norfolk and Norwich University Hospital, Norwich, UK. garymisselbrook@doctors.org.uk
authors.forename: G P
authors.initials: GP
authors.lastname: Misselbrook
authors.forename: E J
authors.initials: EJ
authors.lastname: Hamilton
mesh_terms: D000328:Adult; D003512:Cyclohexanones / Q000506:poisoning*; D003514:Cyclohexylamines / Q000506:poisoning*; D015198:Designer Drugs / Q000506:poisoning*; D062787:Drug Overdose / Q000209:etiology / Q000628:therapy; D004636:Emergency Service, Hospital; D004638:Emergency Treatment / Q000379:methods; D005500:Follow-Up Studies; D006801:Humans; D013287:Illicit Drugs / Q000506:poisoning*; D015994:Incidence; D008297:Male; D008875:Middle Aged; D020258:Neurotoxicity Syndromes / Q000209:etiology* / Q000628:therapy; D010622:Phencyclidine / Q000031:analogs & derivatives* / Q000506:poisoning; D018570:Risk Assessment; D019966:Substance-Related Disorders / Q000150:complications* / Q000628:therapy; D016896:Treatment Outcome
chemical_list: D003512:Cyclohexanones; D003514:Cyclohexylamines; D015198:Designer Drugs; D013287:Illicit Drugs; C578785:methoxydine; D010622:Phencyclidine; C569113:2-(3-methoxyphenyl)-2-(ethylamino)cyclohexanone