title: [The role of the type-three secretion system of the gram-negative bacteria in regulation of chronic infections].
abstract: The role of the type-three secretion system of the gram-negative bacteria in regulation of chronic infections is discussed. Recent research showed that most of severe chronic somatic diseases are derived from chronic infection induced in the first place by infectious agents. The role of the T3SS of different species in transition from an acute infection to persistence is reviewed. Clinical and bacteriological research showed that microorganisms are persistent in the form resistant to antibiotics. That is why one of the promising targets for the development of antibacterial new-generation treatment is T3SS that conducts transport of bacteria pathogenicity factors into eukaryotic cell. The presence of this structure is necessary for the development of an acute infectious process and chronization of an infection is essential for its functioning.
authors.forename: N A
authors.initials: NA
authors.lastname: Zigangirova
authors.forename: L N
authors.initials: LN
authors.lastname: Nesterenko
authors.forename: I G
authors.initials: IG
authors.lastname: Tiganova
authors.forename: E A
authors.initials: EA
authors.lastname: Kost
mesh_terms: D001424:Bacterial Infections / Q000235:genetics / Q000378:metabolism / Q000473:pathology; D001426:Bacterial Proteins / Q000235:genetics / Q000378:metabolism; D058947:Bacterial Secretion Systems / Q000235:genetics / Q000502:physiology; D002689:Chlamydia / Q000378:metabolism / Q000472:pathogenicity; D002908:Chronic Disease; D004352:Drug Resistance, Microbial / Q000235:genetics; D006801:Humans; D012475:Salmonella / Q000378:metabolism / Q000472:pathogenicity; D037521:Virulence Factors / Q000235:genetics / Q000378:metabolism; D015007:Yersinia / Q000378:metabolism / Q000472:pathogenicity
chemical_list: D001426:Bacterial Proteins; D058947:Bacterial Secretion Systems; D037521:Virulence Factors