title: Nitric oxide donor-based platinum complexes as potential anticancer agents.
abstract: Joining forces: Platinum complexes containing organic nitrate ligands were investigated as anticancer agents. The complexes, which were stable in aqueous solution, showed cytotoxicity that was superior to that of the corresponding parent compound (carboplatin), thus suggesting an interesting synergy between the ability of the nitrate-based ligands to release nitric oxide and the ability of the platinum moiety to inhibit DNA synthesis (see scheme).
authors.affiliation: Pharmaceutical Research Center, School of Chemistry and Chemical Engineering, Southeast University, Nanjing 211189, PR China.
authors.forename: Jian
authors.initials: J
authors.lastname: Zhao
authors.forename: Shaohua
authors.initials: S
authors.lastname: Gou
authors.forename: Yanyan
authors.initials: Y
authors.lastname: Sun
authors.forename: Runting
authors.initials: R
authors.lastname: Yin
authors.forename: Zhimei
authors.initials: Z
authors.lastname: Wang
mesh_terms: D018906:Antineoplastic Agents, Alkylating / Q000138:chemical synthesis / Q000737:chemistry* / Q000633:toxicity; D059447:Cell Cycle Checkpoints / Q000187:drug effects; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D056831:Coordination Complexes / Q000138:chemical synthesis / Q000737:chemistry* / Q000633:toxicity; D004247:DNA / Q000737:chemistry / Q000378:metabolism; D053837:DNA Cleavage / Q000187:drug effects; D045325:HCT116 Cells; D056945:Hep G2 Cells; D006801:Humans; D061986:MCF-7 Cells; D009569:Nitric Oxide / Q000737:chemistry*; D010984:Platinum / Q000737:chemistry*
chemical_list: D018906:Antineoplastic Agents, Alkylating; D056831:Coordination Complexes; D009569:Nitric Oxide; D010984:Platinum; D004247:DNA