title: iPSC technology to study human aging and aging-related disorders.
abstract: A global aging population, normally accompanied by a high incidence of aging-associated diseases, has prompted a renewed interest in basic research on human aging. Although encouraging progress has been achieved using animal models, the underlying fundamental mechanisms of aging remain largely unknown. Here, we review the human induced pluripotent stem cell (hiPSC)-based models of aging and aging-related diseases. These models seek to advance our knowledge of aging molecular mechanisms and help to develop strategies for treating aging-associated human diseases.
authors.affiliation: National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China. ghliu@ibp.ac.cn
authors.forename: Guang-Hui
authors.initials: GH
authors.lastname: Liu
authors.forename: Zhichao
authors.initials: Z
authors.lastname: Ding
authors.forename: Juan Carlos
authors.initials: JC
authors.lastname: Izpisua Belmonte
mesh_terms: D000375:Aging / Q000473:pathology; D000818:Animals; D001709:Biotechnology / Q000379:methods*; D006801:Humans; D057026:Induced Pluripotent Stem Cells / Q000166:cytology*; D008954:Models, Biological; D019636:Neurodegenerative Diseases / Q000473:pathology; D011371:Progeria / Q000473:pathology; D057905:Stem Cell Research; D016615:Telomere / Q000473:pathology