title: [Criteria of antibacterials choice for prophylaxis and therapy of implant-associated infections in prosthetic joints].
abstract: Prosthetic joints infection is a serious medical, social and financial problem. Significant achievements in prophylaxis of such infections are well known. In cases of primary endoprosthetics of large joints, the frequency of infection in the leading world clinics is 0.5-2%. However, the approaches to the treatment of such infections are different especially with respect to the antibacterial therapy: choice of drugs, administration routes, treatment course and discontinuation. Under conditions of global growth of resistance in nosocomial pathogens, the choice of antimicrobials requires consideration not only of the formal susceptibility criteria, but also of the pharmacokinetic and pharmacodynamic indices.
authors.forename: N V
authors.initials: NV
authors.lastname: Petrova
authors.forename: V P
authors.initials: VP
authors.lastname: Shevchenko
authors.forename: V V
authors.initials: VV
authors.lastname: Pavlov
authors.forename: V M
authors.initials: VM
authors.lastname: Prokhorenko
authors.forename: V N
authors.initials: VN
authors.lastname: Gol'nik
mesh_terms: D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D018441:Biofilms / Q000187:drug effects; D003428:Cross Infection / Q000188:drug therapy / Q000517:prevention & control; D016905:Gram-Negative Bacterial Infections / Q000188:drug therapy / Q000517:prevention & control; D016908:Gram-Positive Bacterial Infections / Q000188:drug therapy / Q000517:prevention & control; D006801:Humans; D007595:Joint Prosthesis / Q000009:adverse effects*; D008826:Microbial Sensitivity Tests; D019990:Perioperative Care; D016459:Prosthesis-Related Infections / Q000188:drug therapy / Q000382:microbiology / Q000517:prevention & control*
chemical_list: D000900:Anti-Bacterial Agents