title: One dodecahedral bismuth(III) complex derived from 2-acetylpyridine N(4)-pyridylthiosemicarbazone: synthesis, crystal structure and biological evaluation.
abstract: One dodecahedral bismuth(III) complex [Bi(HL)(NO(3))(3)] (1) (HL = 2-acetylpyridine N(4)-pyridylthiosemicarbazone) has been synthesized and structurally characterized. The analytical data reveals the formation of 1 : 1 (metal : ligand) stoichiometry. The bismuth(III) ion is nine-coordinated by one electron pair (6s(2)) of the bismuth(III) atom, two nitrogen and one sulfur atoms from the N(2)S tridentate ligand and five oxygen atoms from three nitrate ions. Biological studies, carried out in vitro against eight selected bacteria, and four human cancer cells, respectively, have indicated that 1 shows better growth-inhibiting properties. Upon further investigation, 1 might produce cytotoxicity through apoptosis.
authors.affiliation: Institute of Molecular and Crystal Engineering, College of Chemistry and Chemical Engineering, Henan University, Kaifeng 475004, PR China. limingxue@henu.edu.cn
authors.forename: Mingxue
authors.initials: M
authors.lastname: Li
authors.forename: Yanli
authors.initials: Y
authors.lastname: Lu
authors.forename: Min
authors.initials: M
authors.lastname: Yang
authors.forename: Yanke
authors.initials: Y
authors.lastname: Li
authors.forename: Lizhi
authors.initials: L
authors.lastname: Zhang
authors.forename: Songqiang
authors.initials: S
authors.lastname: Xie
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry* / Q000494:pharmacology; D000970:Antineoplastic Agents / Q000737:chemistry* / Q000494:pharmacology; D017209:Apoptosis / Q000187:drug effects; D001419:Bacteria / Q000187:drug effects; D001729:Bismuth / Q000737:chemistry* / Q000494:pharmacology; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D056831:Coordination Complexes / Q000737:chemistry* / Q000494:pharmacology; D003460:Crystallization; D006801:Humans; D008826:Microbial Sensitivity Tests; D013882:Thiosemicarbazones / Q000737:chemistry* / Q000494:pharmacology
chemical_list: D000900:Anti-Bacterial Agents; D000970:Antineoplastic Agents; D056831:Coordination Complexes; D013882:Thiosemicarbazones; D001729:Bismuth