title: [Toll like receptors and malaria parasites invasion: progress and prospective].
abstract: To deeply study the molecular mechanism of infection and reproduction of malaria parasites, this review began with co-relationship between toll like receptors (TLRs) and the parasites, further discussed how the parasites were recognized by TLRs and activated downstream inflammation reactions when the mechanical barrier of host was broken through. Some large molecules involved into the process had the potential to be novel drug targets.
authors.affiliation: Department of Parasitology, Xinxiang Medical University, Xinxiang 453003, China.
authors.forename: Fei
authors.initials: F
authors.lastname: Sun
authors.forename: Bing-Hong
authors.initials: BH
authors.lastname: Xu
mesh_terms: D000818:Animals; D000962:Antimalarials / Q000494:pharmacology / Q000627:therapeutic use; D004351:Drug Resistance / Q000235:genetics; D006801:Humans; D008288:Malaria / Q000188:drug therapy / Q000276:immunology* / Q000378:metabolism*; D010961:Plasmodium / Q000187:drug effects / Q000235:genetics / Q000276:immunology; D051193:Toll-Like Receptors / Q000276:immunology / Q000378:metabolism*
chemical_list: D000962:Antimalarials; D051193:Toll-Like Receptors