title: The relationship between zinc intake and serum/plasma zinc concentration in children: a systematic review and dose-response meta-analysis.
abstract: Recommendations for zinc intake during childhood vary widely across Europe. The EURRECA project attempts to consolidate the basis for the definition of micronutrient requirements, taking into account relationships among intake, status and health outcomes, in order to harmonise these recommendations. Data on zinc intake and biomarkers of zinc status reported in randomised controlled trials (RCTs) can provide estimates of dose-response relationships which may be used for underpinning zinc reference values. This systematic review included all RCTs of apparently healthy children aged 1-17 years published by February 2010 which provided data on zinc intake and biomarkers of zinc status. An intake-status regression coefficient (β) was calculated for each individual study and calculated the overall pooled and SE (β) using random effects meta-analysis on a double log scale. The pooled dose-response relationship between zinc intake and zinc status indicated that a doubling of the zinc intake increased the serum/plasma zinc status by 9%. This evidence can be utilised, together with currently used balance studies and repletion/depletion studies, when setting zinc recommendations as a basis for nutrition policies.
authors.affiliation: Maternal & Infant Nutrition & Nurture Unit, University of Central Lancashire, Preston, UK. VLMoran@uclan.ac.uk
authors.forename: Victoria Hall
authors.initials: VH
authors.lastname: Moran
authors.forename: Anna-Louise
authors.initials: AL
authors.lastname: Stammers
authors.forename: Marisol Warthon
authors.initials: MW
authors.lastname: Medina
authors.forename: Sujata
authors.initials: S
authors.lastname: Patel
authors.forename: Fiona
authors.initials: F
authors.lastname: Dykes
authors.forename: Olga W
authors.initials: OW
authors.lastname: Souverein
authors.forename: Carla
authors.initials: C
authors.lastname: Dullemeijer
authors.forename: Carmen
authors.initials: C
authors.lastname: Pérez-Rodrigo
authors.forename: Lluis
authors.initials: L
authors.lastname: Serra-Majem
authors.forename: Mariela
authors.initials: M
authors.lastname: Nissensohn
authors.forename: Nicola M
authors.initials: NM
authors.lastname: Lowe
mesh_terms: D015415:Biomarkers; D002648:Child; D002664:Child Nutritional Physiological Phenomena; D004305:Dose-Response Relationship, Drug; D006801:Humans; D015032:Zinc / Q000008:administration & dosage* / Q000097:blood*
chemical_list: D015415:Biomarkers; D015032:Zinc