title: Developmental iodine deficiency delays the maturation of newborn granule neurons associated with downregulation of p35 in postnatal rat hippocampus.
abstract: We evaluated the role of p35 in the maturation of hippocampal granule neurons in offspring caused by developmental iodine deficiency. Two developmental rat models were established with either an iodine-deficient diet, or propylthiouracil-adulterated water (5 ppm) to impair thyroid function, in pregnant rats from gestational day 6 until postnatal day 28. The protein levels of p35, cyclin-dependent kinase 5, β-catenin, and N-cadherin were assessed on postnatal day 14, 21, and 28. Dendritic morphogenesis of newborn granule neurons in dentate gyrus was examined. Developmental hypothyroidism induced by iodine deficiency and PTU treatment delayed the maturation of hippocampal granule neurons in the offspring and decreased the percentage of Dcx-positive neurons that expressed β-catenin on postnatal day 21 and 28. In addition, downregulation of p35 was observed in dentate gyrus of hypothyroid groups. Developmental hypothyroidism induced by iodine deficiency and PTU treatment could delay the maturation of newborn granule neurons in dentate gyrus, and this deficit may be attributed to the downregulation of p35.
authors.affiliation: Department of Occupational and Environmental Health, School of Public Health, China Medical University, Shenyang, Liaoning 110001, People's Republic of China; Liaoning Provincial Key Laboratory of Endocrine Diseases, China Medical University, Shenyang, People's Republic of China; Department of Nutrition and Food Hygiene, School of Public Health, China Medical University, Shenyang, People's Republic of China.
authors.forename: Fei
authors.initials: F
authors.lastname: Yu
authors.forename: Yi
authors.initials: Y
authors.lastname: Wang
authors.forename: Hongde
authors.initials: H
authors.lastname: Xu
authors.forename: Jing
authors.initials: J
authors.lastname: Dong
authors.forename: Wei
authors.initials: W
authors.lastname: Wei
authors.forename: Yuan
authors.initials: Y
authors.lastname: Wang
authors.forename: Zhongyan
authors.initials: Z
authors.lastname: Shan
authors.forename: Weiping
authors.initials: W
authors.lastname: Teng
authors.forename: Qi
authors.initials: Q
authors.lastname: Xi
authors.forename: Jie
authors.initials: J
authors.lastname: Chen
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D018891:Dentate Gyrus / Q000254:growth & development / Q000378:metabolism; D000089662:Doublecortin Protein; D015536:Down-Regulation; D005260:Female; D006624:Hippocampus / Q000254:growth & development / Q000378:metabolism*; D007037:Hypothyroidism / Q000378:metabolism; D007455:Iodine / Q000172:deficiency*; D018811:Maternal Exposure; D009474:Neurons / Q000378:metabolism*; D010770:Phosphotransferases / Q000378:metabolism*; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects / Q000378:metabolism; D011441:Propylthiouracil / Q000633:toxicity; D051381:Rats; D017208:Rats, Wistar
chemical_list: C492235:Cdk5r1 protein, rat; C000714848:Dcx protein, rat; D000089662:Doublecortin Protein; D011441:Propylthiouracil; D007455:Iodine; D010770:Phosphotransferases