title: [Comparison of diffusion tensor imaging-derived fractional anisotropy in multiple centers for identical human subjects].
abstract: The fractional anisotropy (FA) is calculated by using diffusion tensor imaging (DTI) with multiple motion probing gradients (MPG). While FA has become a widely used tool to detect moderate changes in water diffusion in brain tissue, the measured value is sensitive to scan parameters (e.g. MPG-direction, signal to noise ratio, etc.). Therefore, it is paramount to address the reproducibility of DTI measurements among multiple centers. The purpose of this study was to assess the inter-center variability of FA. We studied five healthy volunteers who underwent DTI brain scanning three times at three different centers (I-III), each with a 1.5 T scanner having a different MPG-schema. Then, we compared the FA and eigenvalue from the three centers measured in seven brain regions: splenium of corpus callosum (CCs), genu of corpus callosum (CCg), putamen, posterior limb of internal capsule, cerebral peduncle, optic radiation, and middle cerebellar peduncle. At the CCs and CCg, there was a statistical difference (p<0.05) between center Iand center IIfor the same MPG-directions. Furthermore, at CCs and CCg, there was a statistical difference (p<0.05) between center II and center III for different MPG-directions. Conversely, no statistical differences were found between center I and center III for the different MPG-directions for all regions. These results indicate that the FA value was affected by the MPG-schema as well as by the MPG-directions.
authors.affiliation: Center for Cybernics Research, University of Tsukuba.
authors.forename: Kousaku
authors.initials: K
authors.lastname: Saotome
authors.forename: Yoshiyuki
authors.initials: Y
authors.lastname: Ishimori
authors.forename: Tomonori
authors.initials: T
authors.lastname: Isobe
authors.forename: Eisuke
authors.initials: E
authors.lastname: Satou
authors.forename: Kazuya
authors.initials: K
authors.lastname: Shinoda
authors.forename: Jun
authors.initials: J
authors.lastname: Ookubo
authors.forename: Yuuji
authors.initials: Y
authors.lastname: Hirano
authors.forename: Satoru
authors.initials: S
authors.lastname: Oosuka
authors.forename: Akira
authors.initials: A
authors.lastname: Matsushita
authors.forename: Katsumi
authors.initials: K
authors.lastname: Miyamoto
authors.forename: Yoshiyuki
authors.initials: Y
authors.lastname: Sankai
mesh_terms: D016880:Anisotropy; D001921:Brain; D003337:Corpus Callosum; D056324:Diffusion Tensor Imaging / Q000379:methods*; D006801:Humans; D020772:Internal Capsule; D011699:Putamen; D015203:Reproducibility of Results; D013681:Tegmentum Mesencephali