title: Vaginal atrophy in breast cancer survivors: role of vaginal estrogen therapy.
abstract: Early menopause and related vaginal atrophy is a well known side-effect of hormone adjuvant treatment in breast cancer patients, particularly during aromatase-inhibitors therapy. Due to estrogens contra-indication, proper therapy for such symptom remains often an inadequately addressed clinical problem. After an accurate assessment of the risk/benefit ratio, vaginal low-dose estrogen treatment (better with estriol) [corrected] may have a role in controlling vaginal atrophy in selected and informed breast cancer women.
authors.affiliation: Department of Gynecologic Oncology, Regina Elena National Cancer Institute of Rome, Rome, Italy. mariani@ifo.it
authors.forename: Luciano
authors.initials: L
authors.lastname: Mariani
authors.forename: Angiolo
authors.initials: A
authors.lastname: Gadducci
authors.forename: Enrico
authors.initials: E
authors.lastname: Vizza
authors.forename: Silverio
authors.initials: S
authors.lastname: Tomao
authors.forename: Patrizia
authors.initials: P
authors.lastname: Vici
mesh_terms: D000282:Administration, Intravaginal; D018931:Antineoplastic Agents, Hormonal / Q000008:administration & dosage / Q000009:adverse effects; D047072:Aromatase Inhibitors / Q000008:administration & dosage / Q000009:adverse effects*; D001284:Atrophy / Q000139:chemically induced / Q000188:drug therapy / Q000473:pathology; D001943:Breast Neoplasms / Q000188:drug therapy* / Q000453:epidemiology; D004964:Estriol / Q000008:administration & dosage*; D004967:Estrogens / Q000008:administration & dosage; D005260:Female; D006801:Humans; D009364:Neoplasm Recurrence, Local / Q000453:epidemiology; D012307:Risk Factors; D017741:Survivors; D013629:Tamoxifen / Q000008:administration & dosage / Q000009:adverse effects*; D014621:Vagina / Q000187:drug effects / Q000473:pathology*; D014623:Vaginal Diseases / Q000139:chemically induced / Q000188:drug therapy / Q000473:pathology
chemical_list: D018931:Antineoplastic Agents, Hormonal; D047072:Aromatase Inhibitors; D004967:Estrogens; D013629:Tamoxifen; D004964:Estriol