title: New flavane gallates isolated from the leaves of Plicosepalus curviflorus and their hypoglycemic activity.
abstract: Two new flavane gallates were isolated from the leaves of Plicosepalus curviflorus. The structure of the new compounds was established as 2S,3R-3,3',4',5,7-pentahydroxyflavane-5-O-gallate (1) and 2S,3R-3,3',4',5,5',7-hexahydroxyflavane-4',5-di-O-gallate (2), respectively. In addition, seven known compounds (-)-catechin (3), quercetin (4), lupeol (5), β-sitosterol (6), pomolic acid (7), β-sitosterol 3-O-β-d-glucopyranoside (8) and 4-methoxycinnamic acid (9) were reported for the first time from the genus Plicosepalus. Compounds 1, 2 and 3 were investigated for their hypoglycemic activity and showed significant hypoglycemic activity in Swiss Albino mice.
authors.affiliation: Department of Pharmacogonosy, College of Pharmacy, King Saud University, Riyadh, P.O. Box 2457, Riyadh 11451, Saudi Arabia.
authors.forename: Areej Mohammad
authors.initials: AM
authors.lastname: Al-Taweel
authors.forename: Shagufta
authors.initials: S
authors.lastname: Perveen
authors.forename: Ghada Ahmed
authors.initials: GA
authors.lastname: Fawzy
authors.forename: Saleh Ibrahim
authors.initials: SI
authors.lastname: Alqasoumi
authors.forename: Kamal E H
authors.initials: KE
authors.lastname: El Tahir
mesh_terms: D005707:Gallic Acid / Q000031:analogs & derivatives* / Q000737:chemistry; D028183:Loranthaceae / Q000737:chemistry*; D015394:Molecular Structure; D018515:Plant Leaves / Q000737:chemistry
chemical_list: D005707:Gallic Acid