title: Expression of ERCC1 and class III β-tubulin is associated with the survival of resected stage III non-small cell lung cancer patients treated with induction chemoradiotherapy using carboplatin-taxane.
abstract: Several molecules have been proven to be associated with responsiveness to chemotherapy. A clinical study on the expression of excision repair cross-complementing (ERCC)-1 and class III β-tubulin was conducted in advanced stage non-small cell lung cancer (NSCLC) patients. We investigated 34 resected stage III NSCLC patients treated with induction chemoradiotherapy using carboplatin-taxane. Immunohistochemistry was performed to evaluate the intratumoral expression of ERCC1 and class III β-tubulin. Nineteen tumors (55.9%) were ERCC1-high and 11 (32.4%) were class III β-tubulin-high. There was no correlation between ERCC1 and class III β-tubulin expression (r=0.208). Regarding the pathological effect of induction therapy, the percentage of ERCC1-positive tumor cells was lower in tumors with a major response than in tumors with a minor response (P=0.0851). The percentage of class III β-tubulin-positive tumor cells was significantly lower in tumors with a major response than in tumors with a minor response (P=0.0105). Regarding patient survival, the overall survival was significantly higher in patients with ERCC1-low tumors than in those with ERCC1-high tumors (P=0.0034). The overall survival was also significantly higher in patients with class III β-tubulin-low tumors than in those with class III β-tubulin-high tumors (P=0.0185). Cox regression analysis also demonstrated that ERCC1 (P=0.0467) and class III β-tubulin statuses (P=0.0237) were significant prognostic factors. Co-evaluations of the intratumoral expression of ERCC1 and class III β-tubulin are clinically useful for identifying patient populations responsive to chemotherapy using carboplatin-taxane.
authors.affiliation: Departments of General Thoracic Surgery, Breast and Endocrinological Surgery, and.
authors.forename: Cheng-Long
authors.initials: CL
authors.lastname: Huang
authors.forename: Kyuichi
authors.initials: K
authors.lastname: Kadota
authors.forename: Dage
authors.initials: D
authors.lastname: Liu
authors.forename: Masaki
authors.initials: M
authors.lastname: Ueno
authors.forename: Nariyasu
authors.initials: N
authors.lastname: Nakasima
authors.forename: Shinya
authors.initials: S
authors.lastname: Ishikawa
authors.forename: Masashi
authors.initials: M
authors.lastname: Gotoh
authors.forename: Noriyuki
authors.initials: N
authors.lastname: Misaki
authors.forename: Sung-Soo
authors.initials: SS
authors.lastname: Chang
authors.forename: Hiroyasu
authors.initials: H
authors.lastname: Yokomise