title: [Antidote therapy for acute carbon monoxide poisoning].
abstract: OBJECTIVE
  To evaluate the antidote properties of acizol in acute carbon monoxide poisoning (ACMP).
  
  
  METHODS
  The study included 70 patients with ACMP. Of them 35 patients received a package of medical measures, which involved 6% acizol solution injected in a dose of 1 ml on hospital admission and an hour later. The efficacy of acizol was evaluated using clinical and laboratory studies.
  
  
  RESULTS
  Just an hour after acizol injection, there was an average 2-fold reduction in the blood concentration of carboxyhemoglobin as compared to the baseline levels. Consciousness recovered 1.5 times more quickly than in the control group. The clinical efficacy of acizol was supported by positive laboratory tests.
  
  
  CONCLUSIONS
  The use of acizol in ACMP assists in increasing the rate of detoxification and positively affects some blood laboratory parameters.
authors.forename: K K
authors.initials: KK
authors.lastname: Il'iashenko
authors.forename: M V
authors.initials: MV
authors.lastname: Belova
authors.forename: I S
authors.initials: IS
authors.lastname: Kashtanova
mesh_terms: D000328:Adult; D000368:Aged; D000931:Antidotes / Q000008:administration & dosage* / Q000493:pharmacokinetics; D002249:Carbon Monoxide Poisoning / Q000175:diagnosis / Q000188:drug therapy*; D005260:Female; D023261:Glasgow Outcome Scale; D006801:Humans; D007093:Imidazoles / Q000008:administration & dosage* / Q000493:pharmacokinetics; D007267:Injections; D008297:Male; D008875:Middle Aged; D009942:Organometallic Compounds / Q000008:administration & dosage* / Q000493:pharmacokinetics; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D000931:Antidotes; D007093:Imidazoles; D009942:Organometallic Compounds; C085860:atsizol