title: [Tissue distribution of ginsenoside Rg1 before and after modification by PEG].
abstract: OBJECTIVE
  To investigate targeted distribution of ginsenoside Rg1 in mice tissues before and after modification by the PEG.
  
  
  METHODS
  SD mice were randomly divided into two groups and given Rg1 and PEG-Rg1 by intravenous injection respectively. Their samples of blood and organ tissues were taken at different time points. The content of Rg1 in samples were determined by UPLC and used as indicator to observe the targeted distribution of Rg1 in mice tissues.
  
  
  RESULTS
  The AUC of ginsenoside Rg1 in tissues of the Rg1 group were in the order of liver, kidney, lung, heart and spleen, with the liver targeting coefficient was of 2.01. While the AUC of ginsenoside Rg1 in tissues of the PEG-modified group were in the order of the kidney, liver, lung, heart, spleen, with the liver targeting coefficient was of 9.21.
  
  
  CONCLUSIONS
  PEG modified Rg1 can increase Rg1's targeting selectivity to the liver, kidney and lung in mice.
authors.affiliation: Murad Research Center for Traditional Chinese Medicine Modernization, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China. lmcao@hotmail.com
authors.forename: Mei
authors.initials: M
authors.lastname: Liu
authors.forename: Li
authors.initials: L
authors.lastname: Wang
authors.forename: Kaili
authors.initials: K
authors.lastname: Hu
authors.forename: Jianfang
authors.initials: J
authors.lastname: Feng
mesh_terms: D000818:Animals; D002138:Calibration; D036145:Ginsenosides / Q000737:chemistry* / Q000493:pharmacokinetics*; D051379:Mice; D011092:Polyethylene Glycols / Q000737:chemistry*; D014018:Tissue Distribution
chemical_list: D036145:Ginsenosides; D011092:Polyethylene Glycols; C035054:ginsenoside Rg1