title: Lack of association between TNF-α promoter polymorphisms and multiple myeloma: a meta-analysis.
abstract: Results of available literatures, which concerned the association between TNF-α promoter -238/-308 gene polymorphisms and multiple myeloma (MM), are of great controversy. A review was performed in studies reporting on the association between them. Odds ratios (ORs) with 95% confidence interval (CI) were used to evaluate the association. The pooled ORs indicated that there was no association between TNF-α -238/-308 polymorphisms and MM susceptibility in overall population. Sub-group analysis also confirmed that no evidence supported the relevance of TNF-α promoter -238/-308 gene polymorphisms with MM. Studies with large sample size and multi-ethnics may be needed to further explore the association between them.
authors.affiliation: Department of Orthopeadics, Tianjin Hospital, Tianjin Medical University, Tianjin, China.
authors.forename: Bing
authors.initials: B
authors.lastname: Li
authors.forename: Xiao-Dan
authors.initials: XD
authors.lastname: Wang
authors.forename: Xiaolei
authors.initials: X
authors.lastname: Sun
authors.forename: Jianxiong
authors.initials: J
authors.lastname: Ma
authors.forename: Yang
authors.initials: Y
authors.lastname: Yang
authors.forename: Xinlong
authors.initials: X
authors.lastname: Ma
mesh_terms: D000368:Aged; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009101:Multiple Myeloma / Q000235:genetics*; D011110:Polymorphism, Genetic; D011401:Promoter Regions, Genetic; D017594:Publication Bias; D014409:Tumor Necrosis Factor-alpha / Q000235:genetics*
chemical_list: D014409:Tumor Necrosis Factor-alpha