title: Serum chitotriosidase activity in acute coronary syndrome.
abstract: OBJECTIVE
  Inflammation is a critical participant in mediating all stages of cardiovascular disease. Studies related with chitotriosidase that was recently found to be relevant to arterial inflammation. In this study we evaluated activity of serum chitotriosidase in acute coronary syndrome patients and its relationship with cardiovascular events, cardiac enzymes and inflammatory indicators.
  
  
  METHODS
  We prospectively analyzed consecutive 30 patients with ST-segment elevation myocardial infarction, 30 patients with non ST-segment elevation myocardial infarction, 30 patients with unstable angina pectroris who were admitted to our intensive care unit and 30 healthy people (average age 56.86±10.44 years, 81 male) between Jaunary and June 2010. Details of baseline clinical characteristics, biochemical values, receiving treatment and basal ECG findings were recorded. Data of patients with coronary angiography were evaluated.
  
  
  RESULTS
  Cut off value of chitotriosidase was calculated 82.00 mmol·ml-1·h-1, with 83 percent sensitivity and 72 percent spesificity. The activity of chitotriosidase in acute coronary syndrome group was 88.85±23.08 mmol·ml-1 ·h-1, where as the control group was 68.47±28.44 mmol·ml-1·h-1, respectively p=0.001).The highest activity of chitotriosidase (96.11±19.77 mmol·ml-1·h-1) was found in ST-segment elevation myocardial infarction group and the minimal activity of chitotriosidase was in the control group (68.47±28.44 mmol·ml-1·h-1) (p= 0.001). The activity of chitotriosidase in ST-segment elevation myocardial infarction and non ST-segment elevation myocardial infarction groups were significantly higher than control group (p=0.001 and p=0.045). When acute coronary syndrome groups compared to control; a positive correlation was found between chitotriosidase activity and hs-CRP (r=0.21, p= 0.046), troponin T (r=0.25, p=0.016), creatine kinase-MB (r=0.20, p=0.059).
  
  
  CONCLUSIONS
  The activity of chitotriosidase is increased in acute coronary syndrome patients. Chitotriosidase is higher in ST-segment elevation myocardial infaction group than non ST-segment elevation myocardial infarction and unstable angina pectoris group.
authors.affiliation: Department of Cardiology, Denizli State Hospital, Denizli, Turkey. bserhatyildiz@yahoo.com
authors.forename: Bekir Serhat
authors.initials: BS
authors.lastname: Yildiz
authors.forename: Burcu
authors.initials: B
authors.lastname: Barutcuoglu
authors.forename: Yusuf Izzettin
authors.initials: YI
authors.lastname: Alihanoglu
authors.forename: Mustafa Beyazit
authors.initials: MB
authors.lastname: Alkan
authors.forename: Murat
authors.initials: M
authors.lastname: Bilgin
authors.forename: Ilker
authors.initials: I
authors.lastname: Gul
authors.forename: Hasan
authors.initials: H
authors.lastname: Gungor
authors.forename: Fatma
authors.initials: F
authors.lastname: Esin
authors.forename: Ahmet
authors.initials: A
authors.lastname: Sayin
authors.forename: Mehdi
authors.initials: M
authors.lastname: Zoghi
mesh_terms: D054058:Acute Coronary Syndrome / Q000097:blood* / Q000150:complications; D000368:Aged; D000789:Angina, Unstable / Q000097:blood*; D001158:Arteries / Q000473:pathology; D002097:C-Reactive Protein / Q000378:metabolism; D002318:Cardiovascular Diseases / Q000097:blood; D016022:Case-Control Studies; D003402:Creatine Kinase / Q000097:blood; D004562:Electrocardiography; D005260:Female; D006596:Hexosaminidases / Q000097:blood*; D006801:Humans; D007249:Inflammation; D008055:Lipids / Q000032:analysis; D008264:Macrophages / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000097:blood*; D011446:Prospective Studies; D012372:ROC Curve; D020107:Troponin T / Q000097:blood
chemical_list: D008055:Lipids; D020107:Troponin T; D002097:C-Reactive Protein; D003402:Creatine Kinase; D006596:Hexosaminidases; C086400:chitotriosidase