title: A key circulatory defence against asphyxia in infancy--the heart of the matter!
abstract: A resumption of, and escalation in, breathing efforts (hyperpnoea) reflexively accelerates heart rate (HR) and may facilitate cardiac and circulatory recovery from apnoea. We analysed whether this mechanism can produce a sustained rise in HR (tachycardia) when a sleeping infant is confronted by mild, rapidly worsening asphyxia, simulating apnoea. Twenty-seven healthy term-born infants aged 1-8 days rebreathed the expired gas for 90 s during quiet sleep to stimulate breathing and heart rate. To discriminate cardio-excitatory effects of central respiratory drive, lung inflation, hypoxia, hypercapnia and asphyxia, we varied the inspired O(2) level and compared temporal changes in response profiles as respiratory sensitivity to hypoxia and asphyxia 'reset' after birth. We demonstrate that asphyxia-induced hyperpnoea and tachycardia strengthen dramatically over the first week with different time courses and via separate mechanisms. Cardiac excitation by hypercapnia improves first, followed by a slower improvement in respiratory hypoxic drive. A rise in CO(2) consequently elicits stronger, longer lasting tachycardia than moderate increases in respiratory drive or lung expansion. We suggest that without a strong facilitating action of CO(2) on the immature heart, respiratory manoeuvres may be unable to reflexively counteract strong vagal bradycardia. This may increase the vulnerability of some infants to apnoea-asphyxia.
authors.affiliation: Department of Neonatal Medicine, Royal Prince Alfred Hospital, Sydney, Australia. gary.cohen@ki.se
authors.forename: Gary
authors.initials: G
authors.lastname: Cohen
authors.forename: Miriam
authors.initials: M
authors.lastname: Katz-Salamon
authors.forename: Girvan
authors.initials: G
authors.lastname: Malcolm
mesh_terms: D001237:Asphyxia / Q000503:physiopathology*; D002245:Carbon Dioxide / Q000502:physiology*; D006339:Heart Rate; D006801:Humans; D007231:Infant, Newborn; D012119:Respiration
chemical_list: D002245:Carbon Dioxide