title: Ceftriaxone resistance and genes encoding extended-spectrum β-lactamase among non-typhoidal Salmonella species from a tertiary care hospital in Kuala Lumpur, Malaysia.
abstract: The prevalence of ceftriaxone resistance and the associated genes encoding extended-spectrum β-lactamase  (ESBL) was determined in 149 non-duplicate non-typhoidal Salmonella isolated in 2008-2009 from  patients in a tertiary care hospital in Kuala Lumpur, Malaysia. The resistance rate to ceftriaxone was  2.7% (2/74) in 2008, 4.0% (3/75) in 2009, and 3.4% (5/149) overall. CTX-M ESBL genes were detected in 2 of  the 5 ceftriaxone-resistant isolates. The prevalence of ceftriaxone resistance, although low, is a concern  because it limits therapeutic options. Continued surveillance of ceftriaxone resistance is important to  monitor its trends.
authors.affiliation: Department of Medical Microbiology, University of Malaya, Kuala Lumpur, Malaysia. rina＠ummc.edu.my
authors.forename: Rina
authors.initials: R
authors.lastname: Karunakaran
authors.forename: Sun Tee
authors.initials: ST
authors.lastname: Tay
authors.forename: Fairuz Fadzilah
authors.initials: FF
authors.lastname: Rahim
authors.forename: Bee Bee
authors.initials: BB
authors.lastname: Lim
authors.forename: I-Ching
authors.initials: IC
authors.lastname: Sam
authors.forename: Maria
authors.initials: M
authors.lastname: Kahar-Bador
authors.forename: Hamimah
authors.initials: H
authors.lastname: Hassan
authors.forename: Savithri Devi
authors.initials: SD
authors.lastname: Puthucheary
mesh_terms: D016470:Bacteremia / Q000382:microbiology; D001426:Bacterial Proteins / Q000235:genetics*; D002443:Ceftriaxone / Q000494:pharmacology*; D005243:Feces / Q000382:microbiology; D006801:Humans; D008296:Malaysia; D012475:Salmonella / Q000187:drug effects* / Q000201:enzymology / Q000235:genetics*; D012480:Salmonella Infections / Q000382:microbiology*; D062606:Tertiary Care Centers; D018440:beta-Lactam Resistance; D001618:beta-Lactamases / Q000235:genetics*
chemical_list: D001426:Bacterial Proteins; D002443:Ceftriaxone; D001618:beta-Lactamases