title: Comparison between the prognostic value of the white blood cell differential count and morphological parameters of neutrophils and lymphocytes in severely injured patients for 7-day in-hospital mortality.
abstract: BACKGROUND
  Current laboratory parameters provide limited information about the prognosis of severely injured patients; therefore, novel laboratory parameters are needed.
  
  
  METHODS
  We compared the morphological parameters of neutrophils and lymphocytes, and white blood cell (WBC) differential count between survivors and nonsurvivors within 7 days after admission. Multiple logistic regression analysis was conducted to identify independent prognostic factors for 7-day in-hospital mortality.
  
  
  RESULTS
  Neutrophil cell size was significantly different between survivors and nonsurvivors (p = 0.04), whereas WBC count and differential were not significantly different. Multiple logistic regression showed that neutrophil cell size was a significant predictor of poor outcome.
  
  
  CONCLUSIONS
  Neutrophil cell size at admission is a prognostic factor for 7-day in-hospital mortality in severely injured trauma patients, whereas conventional WBC count and differential have no prognostic value.
authors.affiliation: Department of Surgery, University Medical Center Utrecht, Utrecht, The Netherlands.
authors.forename: Siu W
authors.initials: SW
authors.lastname: Lam
authors.forename: Luke P H
authors.initials: LP
authors.lastname: Leenen
authors.forename: Wouter W
authors.initials: WW
authors.lastname: van Solinge
authors.forename: Falco
authors.initials: F
authors.lastname: Hietbrink
authors.forename: Albert
authors.initials: A
authors.lastname: Huisman
mesh_terms: D000328:Adult; D000368:Aged; D048430:Cell Shape; D048429:Cell Size; D005260:Female; D006801:Humans; D015601:Injury Severity Score; D007902:Length of Stay; D007958:Leukocyte Count; D016015:Logistic Models; D008214:Lymphocytes / Q000502:physiology*; D008297:Male; D008875:Middle Aged; D009504:Neutrophils / Q000502:physiology*; D011379:Prognosis; D011446:Prospective Studies; D014949:Wounds, Nonpenetrating / Q000097:blood / Q000175:diagnosis / Q000401:mortality*