title: Influence of anti-Nogo-A antibody treatment on the reorganization of callosal connectivity of the premotor cortical areas following unilateral lesion of primary motor cortex (M1) in adult macaque monkeys.
abstract: Following unilateral lesion of the primary motor cortex, the reorganization of callosal projections from the intact hemisphere to the ipsilesional premotor cortex (PM) was investigated in 7 adult macaque monkeys, in absence of treatment (control; n = 4) or treated with function blocking antibodies against the neurite growth inhibitory protein Nogo-A (n = 3). After functional recovery, though incomplete, the tracer biotinylated dextran amine (BDA) was injected in the ipsilesional PM. Retrogradely labelled neurons were plotted in the intact hemisphere and their number was normalized with respect to the volume of the core of BDA injection sites. (1) The callosal projections to PM in the controls originate mainly from homotypic PM areas and, but to a somewhat lesser extent, from the mesial cortex (cingulate and supplementary motor areas). (2) In the lesioned anti-Nogo-A antibody-treated monkeys, the normalized number of callosal retrogradely labelled neurons was up to several folds higher than in controls, especially in the homotypic PM areas. (3) Except one control with a small lesion and a limited, transient deficit, the anti-Nogo-A antibody-treated monkeys recovered to nearly baseline levels of performance (73-90 %), in contrast to persistent deficits in the control monkeys. These results are consistent with a sprouting and/or sparing of callosal axons promoted by the anti-Nogo-A antibody treatment after lesion of the primary motor cortex, as compared to untreated monkeys.
authors.affiliation: Program in Neurosciences, Department of Medicine, Faculty of Sciences and Fribourg Centre for Cognition, University of Fribourg, Chemin du Musée 5, 1700, Fribourg, Switzerland.
authors.forename: Adjia
authors.initials: A
authors.lastname: Hamadjida
authors.forename: Alexander F
authors.initials: AF
authors.lastname: Wyss
authors.forename: Anis
authors.initials: A
authors.lastname: Mir
authors.forename: Martin E
authors.initials: ME
authors.lastname: Schwab
authors.forename: Abderaouf
authors.initials: A
authors.lastname: Belhaj-Saif
authors.forename: Eric M
authors.initials: EM
authors.lastname: Rouiller
mesh_terms: D000818:Animals; D019138:Antibodies, Blocking / Q000008:administration & dosage* / Q000494:pharmacology; D001927:Brain Diseases / Q000276:immunology* / Q000473:pathology / Q000503:physiopathology; D003337:Corpus Callosum / Q000276:immunology* / Q000473:pathology; D008252:Macaca fascicularis; D009044:Motor Cortex / Q000276:immunology* / Q000473:pathology; D009185:Myelin Proteins / Q000276:immunology*; D009473:Neuronal Plasticity / Q000187:drug effects / Q000276:immunology*; D000070798:Nogo Proteins; D013003:Somatosensory Cortex / Q000166:cytology / Q000276:immunology
chemical_list: D019138:Antibodies, Blocking; D009185:Myelin Proteins; D000070798:Nogo Proteins