title: Prevention of complications related to the use of prosthetic meshes in prolapse surgery: guidelines for clinical practice.
abstract: The objective of the study was to provide guidelines for clinical practice from the French College of Obstetrics and Gynecology (CNGOF), based on the best evidence available, concerning adverse events related to surgical procedures involving the use of prosthetic meshes. French and English-language articles from Medline, PubMed, and the Cochrane Database were searched, using key words (mesh; pelvic organ prolapse; cystocele; rectocele; uterine prolapse; complications; adverse event; sacral colpopexy; extrusion; infection). As with any surgery, recommendations include perioperative smoking cessation (Expert opinion) and compliance with the prevention of nosocomial infections (regulatory recommendation). There is no evidence to recommend routine local or systemic estrogen therapy before or after prolapse surgery using mesh, regardless of the surgical approach (Grade C). Antibiotic prophylaxis is recommended, regardless of the approach (Expert opinion). It is recommended to check for pre-operative urinary tract infection and treat it (Expert opinion). The first procedure should be undertaken under the guidance of a surgeon experienced in the relevant technique (Grade C). It is recommended not to place a non-absorbable synthetic mesh into the rectovaginal septum when a rectal injury occurs (Expert opinion). Placement of a non-absorbable synthetic mesh into the vesicovaginal septum may be considered after suturing of a bladder injury if the suture is considered to be satisfactory (Expert opinion). If a synthetic mesh is placed by vaginal route, it is recommended to use a macroporous polypropylene monofilament mesh (Grade B). It is recommended not to use polyester mesh for vaginal surgery (Grade B). It is permissible to perform hysterectomy associated with the placement of a non-absorbable synthetic mesh placed by the vaginal route but this is not routinely recommended (Expert opinion). It is recommended to minimize the extent of the colpectomy (Expert opinion). The laparoscopic approach is recommended for sacral colpopexy (Expert opinion). It is recommended not to place and suture meshes by the vaginal route when a sacral colpopexy is performed (Grade B). It is recommended not to use silicone-coated polyester, porcine dermis, fascia lata, and polytetrafluoroethylene meshes (Grade B). It is recommended to use polyester (without silicone coating) or polypropylene meshes (Grade C). Suture of the meshes to the promontory can be performed using thread/needle or tacks (Grade C). Peritonization is recommended to cover the meshes (Grade C). If hysterectomy is required, it is recommended to perform a subtotal hysterectomy (Expert opinion). Implementation of this guideline should decrease the prevalence of complications related to surgical procedures involving the use of prosthetic meshes.
authors.affiliation: AP-HP, Hôpital Antoine Béclère, Service de Gynécologie-Obstétrique et Médecine de la Reproduction, Clamart, F-92141, France. xavier.deffieux@abc.aphp.fr
authors.forename: Xavier
authors.initials: X
authors.lastname: Deffieux
authors.forename: Vincent
authors.initials: V
authors.lastname: Letouzey
authors.forename: Denis
authors.initials: D
authors.lastname: Savary
authors.forename: Loïc
authors.initials: L
authors.lastname: Sentilhes
authors.forename: Aubert
authors.initials: A
authors.lastname: Agostini
authors.forename: Pierre
authors.initials: P
authors.lastname: Mares
authors.forename: Fabrice
authors.initials: F
authors.lastname: Pierre
mesh_terms: D000328:Adult; D019072:Antibiotic Prophylaxis; D003428:Cross Infection / Q000517:prevention & control*; D005260:Female; D006801:Humans; D056887:Pelvic Organ Prolapse / Q000601:surgery*; D011126:Polypropylenes; D011183:Postoperative Complications / Q000517:prevention & control*; D019736:Prostheses and Implants / Q000009:adverse effects; D013526:Surgical Mesh / Q000009:adverse effects*; D013514:Surgical Procedures, Operative / Q000193:education; D014596:Uterine Prolapse / Q000601:surgery
chemical_list: D011126:Polypropylenes