title: Efficacy of 10% sucralfate ointment in the reduction of acute postoperative pain after open hemorrhoidectomy: a prospective, double-blind, randomized, placebo-controlled trial.
abstract: BACKGROUND
  The aim of the present study was to evaluate the efficacy of 10 % sucralfate ointment in the reduction of acute postoperative pain after open hemorrhoidectomy.
  
  
  METHODS
  A total of 48 patients (24 men and 24 women) between 20 and 70 years of age who underwent open hemorrhoidectomy were included in this prospective, double-blind, randomized, controlled trial and were randomly divided into two groups (24 in each group), receiving either sucralfate ointment or placebo immediately after surgery and then every 12 h for 14 days. The primary outcome measure was pain intensity measured by a visual analogue scale at different time points after hemorrhoidectomy.
  
  
  RESULTS
  The sucralfate group had significantly less pain than the placebo group at 24th h and the 48th h after hemorrhoidectomy (4 ± 1.14 vs 5.08 ± 0.97; P = 0.001 and 3 ± 0.72 vs 4.41 ± 0.8; P < 0.001, respectively), and they consumed lower amounts of analgesics at the same time intervals (12.50 ± 16.48 vs 21.87 ± 15.30 mg of pethidine; P = 0.047 and 152 ± 23 vs 172 ± 29 mg of diclofenac; P = 0.009, respectively). The same trend continued until the end of the trial.
  
  
  CONCLUSIONS
  Sucralfate ointment reduced the acute postoperative pain after hemorrhoidectomy.
authors.affiliation: Department of Clinical Pharmacy, Faculty of Pharmacy, Mazandaran University of Medical Sciences, 18th Kilometer Farahabad Road, 48175861 Sari, Mazandaran Province, Iran.
authors.forename: Shahram
authors.initials: S
authors.lastname: Ala
authors.forename: Majid
authors.initials: M
authors.lastname: Saeedi
authors.forename: Fariborz
authors.initials: F
authors.lastname: Eshghi
authors.forename: Mohamadreza
authors.initials: M
authors.lastname: Rafati
authors.forename: Vahid
authors.initials: V
authors.lastname: Hejazi
authors.forename: Roja
authors.initials: R
authors.lastname: Hadianamrei
mesh_terms: D000208:Acute Disease; D000328:Adult; D000368:Aged; D004311:Double-Blind Method; D005260:Female; D061865:Hemorrhoidectomy / Q000379:methods; D006801:Humans; D008297:Male; D008875:Middle Aged; D009824:Ointments; D010149:Postoperative Pain / Q000188:drug therapy*; D011446:Prospective Studies; D013392:Sucralfate / Q000008:administration & dosage*; D055815:Young Adult
chemical_list: D009824:Ointments; D013392:Sucralfate