title: Fish oil supplementation reduces cachexia and tumor growth while improving renal function in tumor-bearing rats.
abstract: The objective of the present work was to study the renal function of healthy and tumor-bearing rats chronically supplemented with fish oil (FO), a source of n-3 polyunsaturated fatty acids. Weanling male rats were divided in two groups, one control (C) and another orally supplemented for 70 days with FO (1 g/kg body weight). After this time, half the animals of each group were injected in the right flank with a suspension of Walker 256 tumor cells (W and WFO). The W group had less proteinemia reflecting cachectic proteolysis, FO reversed this fact. Tumor weight gain was also reduced in WFO. Glomerular filtration rate (GFR) was not different in FO or W compared to C, but was higher in WFO. Renal plasma flow (RPF) was higher in the FO supplemented groups. The W group had lower plasma osmolality than the C group, but FO supplementation resulted in normalization of this parameter. Fractional sodium excretion (FE(Na+)) of FO rats was similar to C. Proximal Na(+) reabsorption, evaluated by lithium clearance, was similar among the groups. Urinary thromboxane B(2) (TXB(2)) excretion was lower in the supplemented groups. The number of macrophages in renal tissue was higher in W compared to C rats, but was lower in WFO rats compared to W rats. In conclusion, FO supplementation resulted in less tumor growth and cachexia, and appeared to be renoprotective, as suggested by higher RPF and GFR.
authors.affiliation: Departamento de Fisiologia, Setor de Ciências Biológicas, Universidade Federal do Paraná Centro Politécnico s/n.-Jd. das Américas, Curitiba, PR 81531-990, Brazil.
authors.forename: Isabela
authors.initials: I
authors.lastname: Coelho
authors.forename: Fernando
authors.initials: F
authors.lastname: Casare
authors.forename: Danielle C T
authors.initials: DC
authors.lastname: Pequito
authors.forename: Gina
authors.initials: G
authors.lastname: Borghetti
authors.forename: Ricardo K
authors.initials: RK
authors.lastname: Yamazaki
authors.forename: Gleisson A P
authors.initials: GA
authors.lastname: Brito
authors.forename: Marcelo
authors.initials: M
authors.lastname: Kryczyk
authors.forename: Luiz Claudio
authors.initials: LC
authors.lastname: Fernandes
authors.forename: Terezila M
authors.initials: TM
authors.lastname: Coimbra
authors.forename: Ricardo
authors.initials: R
authors.lastname: Fernandez
mesh_terms: D000818:Animals; D002100:Cachexia / Q000188:drug therapy*; D049109:Cell Proliferation / Q000187:drug effects; D003404:Creatinine / Q000097:blood / Q000652:urine; D019587:Dietary Supplements; D005395:Fish Oils / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use*; D007150:Immunohistochemistry; D007668:Kidney / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology; D007677:Kidney Function Tests; D008297:Male; D009374:Neoplasms, Experimental / Q000178:diet therapy* / Q000378:metabolism / Q000473:pathology*; D051381:Rats; D017208:Rats, Wistar
chemical_list: D005395:Fish Oils; D003404:Creatinine