title: The importance of Tc-MAA SPECT/CT for therapy planning of radioembolization in a patient treated with bevacizumab.
abstract: A 76-year-old man with colorectal cancer and hepatic metastases was referred to us for radioembolization of the liver. Angiography with 99mTc-MAA SPECT/CT was performed 8 weeks after the discontinuation of bevacizumab. 99mTc-MAA SPECT/CT showed a diffused intrahepatic tracer distribution with no focally accentuated accumulation in the tumorous region. The test was repeated 6 weeks later and Tc-MAA SPECT/CT showed this time a tumor accentuated tracer accumulation in the liver. Subsequently, the patient was treated with resin microspheres. Tc-MAA SPECT/CT allows a better evaluation of intrahepatic tracer accumulation of Tc-MAA and facilitates the determination of the most appropriate treatment time.
authors.affiliation: Department of Nuclear Medicine, University Hospital Bonn, Bonn, Germany. hojjat.ahmadzadehfar@ukb.uni-bon
authors.forename: Hojjat
authors.initials: H
authors.lastname: Ahmadzadehfar
authors.forename: Amir
authors.initials: A
authors.lastname: Sabet
authors.forename: Carsten
authors.initials: C
authors.lastname: Meyer
authors.forename: Elham
authors.initials: E
authors.lastname: Habibi
authors.forename: Hans-Jürgen
authors.initials: HJ
authors.lastname: Biersack
authors.forename: Samer
authors.initials: S
authors.lastname: Ezziddin
mesh_terms: D000368:Aged; D061067:Antibodies, Monoclonal, Humanized / Q000627:therapeutic use*; D000068258:Bevacizumab; D015179:Colorectal Neoplasms / Q000000981:diagnostic imaging / Q000473:pathology; D004621:Embolization, Therapeutic; D006801:Humans; D008113:Liver Neoplasms / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000556:secondary; D008297:Male; D049268:Positron-Emission Tomography; D013668:Technetium Tc 99m Aggregated Albumin; D015899:Tomography, Emission-Computed, Single-Photon; D014057:Tomography, X-Ray Computed
chemical_list: D061067:Antibodies, Monoclonal, Humanized; D013668:Technetium Tc 99m Aggregated Albumin; D000068258:Bevacizumab