title: Lack of association between C3123A polymorphism of the angiotensin II type 2 receptor gene and hypertension in Tunisian population.
abstract: BACKGROUND
  Hypertension is a polygenic disease. Various singlenucleotide gene polymorphisms of renin angiotensin system have been explored in hypertension. Angiotensin II, the major biologically active component of this system, exerts its effect via two pharmacologically distinct subtypes of angiotensin II receptors, the angiotensin II type 1 receptor and the angiotensin II type 2 receptor.
  
  
  OBJECTIVE
  To examine whether the 3123 C/A polymorphism of angiotensin II type 2 receptor gene is involved in hypertension in a sample of Tunisian population.
  
  
  METHODS
  Atotal of 403 normotensive subjects and 382 hypertensive patients were included in the study. Genotyping was performed by polymerase chain reaction followed by Alu I restriction digestion.
  
  
  RESULTS
  The frequency of "A" genotype was not significantly different between the two groups in men (¯2=1.18; p=0.16). The estimated odds prevalence for hypertension ("A" versus "C") was 0.77 (95% CI 0.49 to 1.22, p=0.27). After adjustment for confounding factors, the OR for hypertension remained no significant (OR: 1.49, 95% CI: 0.84-2.63, p=0.16). In women, genotype distributions for C3123A variant in hypertensive patients were not significantly different from normotensive subjects (¯2=3.16; p=0.20). Multiple logistic regression analysis showed that the AA genotype was not significantly associated with hypertension (OR: 1.09, 95% CI: 0.58-2.06, p=0.77).
  
  
  CONCLUSIONS
  In the present study, we showed that the 3123 C/A polymorphism of AGT2R gene is not a significant factor for hypertension in a sample of Tunisian population.
authors.affiliation: Department of Biochemistry, Hospital la Rabta, Tunis, Tunisia.
authors.forename: Ilhem
authors.initials: I
authors.lastname: Ayadi Kabadou
authors.forename: Hayet
authors.initials: H
authors.lastname: Soualmiaa
authors.forename: Riadh
authors.initials: R
authors.lastname: Jemaa
authors.forename: Moncef
authors.initials: M
authors.lastname: Feki
authors.forename: Ameni
authors.initials: A
authors.lastname: Kallel
authors.forename: Omar
authors.initials: O
authors.lastname: Souheil
authors.forename: Sameh
authors.initials: S
authors.lastname: Haj Taieb
authors.forename: Haifa
authors.initials: H
authors.lastname: Sanhaji
authors.forename: Naziha
authors.initials: N
authors.lastname: Kaabachi
mesh_terms: D005260:Female; D006801:Humans; D006973:Hypertension / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic; D044139:Receptor, Angiotensin, Type 2 / Q000235:genetics*
chemical_list: D044139:Receptor, Angiotensin, Type 2