title: Carbon nanotubes enhance metastatic growth of lung carcinoma via up-regulation of myeloid-derived suppressor cells.
abstract: Metastatic establishment and growth of Lewis lung carcinoma is promoted by single-walled carbon nanotubes (SWCNT) in C57BL6/J mice. The effect is mediated by increased local and systemic accumulation of myeloid-derived suppressor cells (MDSC), as their depletion abrogated pro-tumor activity in vivo. These data are important for the design of novel theranostics platforms with modules capable of depleting or functionally suppressing MDSC to ensure effective immunosurveillance in the tumor microenvironment.
authors.affiliation: Health Effects Laboratory Division, NIOSH, 1095 Willowdale Road, Morgantown, WV 26505, USA. ats1@cdc.gov
authors.forename: Anna A
authors.initials: AA
authors.lastname: Shvedova
authors.forename: Alexey V
authors.initials: AV
authors.lastname: Tkach
authors.forename: Elena R
authors.initials: ER
authors.lastname: Kisin
authors.forename: Timur
authors.initials: T
authors.lastname: Khaliullin
authors.forename: Shyla
authors.initials: S
authors.lastname: Stanley
authors.forename: Dmitriy W
authors.initials: DW
authors.lastname: Gutkin
authors.forename: Alexander
authors.initials: A
authors.lastname: Star
authors.forename: Yanan
authors.initials: Y
authors.lastname: Chen
authors.forename: Galina V
authors.initials: GV
authors.lastname: Shurin
authors.forename: Valerian E
authors.initials: VE
authors.lastname: Kagan
authors.forename: Michael R
authors.initials: MR
authors.lastname: Shurin
mesh_terms: D000818:Animals; D001854:Bone Marrow Cells / Q000473:pathology*; D002455:Cell Division; D005260:Female; D008175:Lung Neoplasms / Q000378:metabolism / Q000473:pathology*; D051379:Mice; D008810:Mice, Inbred C57BL; D037742:Nanotubes, Carbon; D015854:Up-Regulation
chemical_list: D037742:Nanotubes, Carbon