title: An unexpected presentation: minimal change disease in an adult with treatment-naïve hepatitis C.
abstract: Minimal change disease is the most common glomerular disease affecting children; its prevalence among adults, however, is eclipsed by other glomerular pathologies. Each of these diseases has a number of classic associations, such as membranoproliferative glomerulonephritis with hepatitis C. We report the case of a middle-aged African-American male who presented with the nephrotic syndrome and acute renal failure and was concomitantly diagnosed with a new hepatitis C infection. He also had a history of urethral strictures with potential reflux nephropathy, which--in combination with his African-American race--also made focal segmental glomerulosclerosis a diagnostic possibility. Full laboratory evaluation did not distinguish the cause of his massive proteinuria; subsequent renal biopsy ultimately revealed minimal change disease. A full course of high-dose steroids eventually reduced his proteinuria, after which his renal failure resolved as well without need for hemodialysis.
authors.affiliation: Department of Internal Medicine, Penn State College of Medicine, Hershey, PA, USA.
authors.forename: Audrey L
authors.initials: AL
authors.lastname: Stokes
authors.forename: Tarek
authors.initials: T
authors.lastname: Alhamad
authors.forename: Catherine S
authors.initials: CS
authors.lastname: Abendroth
authors.forename: Hosam A
authors.initials: HA
authors.lastname: Farag
authors.forename: Navin
authors.initials: N
authors.lastname: Verma
mesh_terms: D058186:Acute Kidney Injury / Q000209:etiology; D019698:Hepatitis C, Chronic / Q000150:complications* / Q000175:diagnosis; D006801:Humans; D008297:Male; D008875:Middle Aged; D009402:Nephrosis, Lipoid / Q000150:complications* / Q000188:drug therapy / Q000473:pathology