title: Lymphangiomatosis of the systemic skin in an old dog.
abstract: A 13-year-old, neutered male miniature dachshund was presented with a one-month history of bilateral symmetrical swelling in the pinnae and carpal, cubital and tarsal joints, and swelling in the tail. The lesions were histopathologically characterized by multiple dilated lymphatic vessels lined by a single attenuated layer of endothelial cells. The subcutis was predominantly involved. A number of spindle-shaped cells lining the irregular vessels were observed. Morphological atypia was not evident in these cells. Immunohistochemical analyses revealed that the proliferating endothelial cells were positive for factor VIII-related antigen and CD31. Based on the clinical presentation and histopathological features, the dog was diagnosed with lymphangiomatosis. Treatment with anti-inflammatory prednisolone improved the symptoms.
authors.affiliation: Department of Veterinary Internal Medicine, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo, Japan.
authors.forename: Shingo
authors.initials: S
authors.lastname: Maeda
authors.forename: Yasuhito
authors.initials: Y
authors.lastname: Fujino
authors.forename: Chie
authors.initials: C
authors.lastname: Tamamoto
authors.forename: Satoshi
authors.initials: S
authors.lastname: Suzuki
authors.forename: Atsushi
authors.initials: A
authors.lastname: Fujita
authors.forename: Masashi
authors.initials: M
authors.lastname: Takahashi
authors.forename: Koichi
authors.initials: K
authors.lastname: Ohno
authors.forename: Kazuyuki
authors.initials: K
authors.lastname: Uchida
authors.forename: Hajime
authors.initials: H
authors.lastname: Tsujimoto
mesh_terms: D000375:Aging; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D004283:Dog Diseases; D004285:Dogs; D008202:Lymphangioma / Q000188:drug therapy / Q000473:pathology / Q000662:veterinary*; D008297:Male; D011239:Prednisolone / Q000627:therapeutic use; D012871:Skin Diseases / Q000188:drug therapy / Q000473:pathology / Q000662:veterinary*
chemical_list: D000893:Anti-Inflammatory Agents; D011239:Prednisolone