title: Relief of intractable posthypoxic myoclonus after administration of agomelatine.
abstract: Chronic posthypoxic myoclonus is characterized by myoclonic jerks that are specifically triggered by action. It is a rare but devastating sequela of hypoxic encephalopathy. We report a 42-year-old female patient with treatment-resistant chronic posthypoxic myoclonus, which improved with administration of the drug agomelatine. We suggest that agomelatine could represent a useful therapeutic option in the treatment of chronic posthypoxic myoclonus.
authors.affiliation: Epilepsy Unit, Department of Neurology, Hospital 12 de Octubre, Madrid, Spain. jesus_goal@yahoo.es
authors.forename: Jesús
authors.initials: J
authors.lastname: González de la Aleja
authors.forename: Rosa Ana
authors.initials: RA
authors.lastname: Saiz-Díaz
authors.forename: Pilar
authors.initials: P
authors.lastname: De la Peña
mesh_terms: D000081:Acetamides / Q000494:pharmacology / Q000627:therapeutic use*; D000328:Adult; D005260:Female; D006801:Humans; D002534:Hypoxia, Brain / Q000150:complications / Q000175:diagnosis* / Q000188:drug therapy*; D008550:Melatonin / Q000819:agonists*; D009207:Myoclonus / Q000175:diagnosis* / Q000188:drug therapy* / Q000209:etiology; D009281:Naphthalenes
chemical_list: D000081:Acetamides; D008550:Melatonin; C084711:agomelatine; D009281:Naphthalenes