title: Foxp3(+) regulatory T cells are increased in the early stages of halo nevi: clinicopathological features of 30 halo nevi.
abstract: BACKGROUND
  There have been few clinical studies of the role of regulatory T cells (Tregs) in halo formation of halo nevus.
  
  
  OBJECTIVE
  To evaluate the clinicopathologic features and the presence of Tregs in halo nevi.
  
  
  METHODS
  We analyzed 30 halo nevi and performed immunohistochemical analysis using antibodies against CD4, CD8, CD25 and Foxp3. We also performed double immunohistochemical staining for Foxp3 and CD25.
  
  
  RESULTS
  We found significant increases in Foxp3(+) Tregs, and the shorter the halo nevus duration, the more Foxp3(+) Tregs were detected. Also, the ratio of Foxp3 to CD8 T cells was increased in early stages of halo nevi. Double immunohistochemical staining suggested that the Tregs in the halo nevi were CD25(+)Foxp3(+) T cells.
  
  
  CONCLUSIONS
  Foxp3(+) Tregs were greatly increased in the halo nevi. The shorter the halo nevi duration, the more Foxp3(+) Tregs were involved in the earlier developmental stages of halo nevi.
authors.affiliation: Department of Dermatology, Chonnam National University Medical School, Gwangju, South Korea.
authors.forename: H S
authors.initials: HS
authors.lastname: Park
authors.forename: S A
authors.initials: SA
authors.lastname: Jin
authors.forename: Y-D
authors.initials: YD
authors.lastname: Choi
authors.forename: M-H
authors.initials: MH
authors.lastname: Shin
authors.forename: S E
authors.initials: SE
authors.lastname: Lee
authors.forename: S J
authors.initials: SJ
authors.lastname: Yun
mesh_terms: D000293:Adolescent; D000328:Adult; D015704:CD4 Antigens / Q000276:immunology*; D002648:Child; D005260:Female; D051858:Forkhead Transcription Factors / Q000276:immunology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D055882:Nevus, Halo / Q000276:immunology / Q000473:pathology*; D012878:Skin Neoplasms / Q000276:immunology / Q000473:pathology*; D050378:T-Lymphocytes, Regulatory / Q000276:immunology*; D055815:Young Adult
chemical_list: D015704:CD4 Antigens; C418974:FOXP3 protein, human; D051858:Forkhead Transcription Factors