title: Palladium-catalyzed annulation of arynes by o-halobenzamides: synthesis of phenanthridinones.
abstract: The palladium-catalyzed annulation of arynes by substituted o-halobenzamides produces N-substituted phenanthridinones in good yields. This methodology provides this important heterocyclic ring system in a single step by simultaneous C-C and C-N bond formation, under relatively mild reaction conditions, and tolerates a variety of functional groups.
authors.affiliation: Department of Chemistry, Iowa State University, Ames, Iowa 50011, United States.
authors.forename: Chun
authors.initials: C
authors.lastname: Lu
authors.forename: Anton V
authors.initials: AV
authors.lastname: Dubrovskiy
authors.forename: Richard C
authors.initials: RC
authors.lastname: Larock
mesh_terms: D001549:Benzamides / Q000737:chemistry*; D002384:Catalysis; D003500:Cyclization; D005449:Fluorenes / Q000138:chemical synthesis* / Q000737:chemistry; D006846:Hydrocarbons, Halogenated / Q000737:chemistry*; D015394:Molecular Structure; D010165:Palladium / Q000737:chemistry*; D010617:Phenanthridines / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D001549:Benzamides; D005449:Fluorenes; D006846:Hydrocarbons, Halogenated; D010617:Phenanthridines; D010165:Palladium