title: Metabolomic analyses of blood plasma after oral administration of D-glucosamine hydrochloride to dogs.
abstract: D-Glucosamine hydrochloride (GlcN∙HCl) is an endogenous amino monosaccharide synthesized from glucose that is useful in the treatment of joint diseases in both humans and animals. The aim of this study was to examine amino acid metabolism in dogs after oral administration of GlcN∙HCl. Accelerated fumarate respiration and elevated plasma levels of lactic acid and alanine were observed after administration. These results suggest that oral administration of GlcN∙HCl induces anaerobic respiration and starvation in cells, and we hypothesize that these conditions promote cartilage regeneration. Further studies are required to evaluate the expression of transforming growth factor-beta (TGF-β).
authors.affiliation: Department of Veterinary Clinical Medicine, School of Veterinary Medicine, Tottori University, 4-101 Koyama-minami, Tottori 680-8553, Japan.
authors.forename: Tomohiro
authors.initials: T
authors.lastname: Osaki
authors.affiliation: Department of Veterinary Clinical Medicine, School of Veterinary Medicine, Tottori University, 4-101 Koyama-minami, Tottori 680-8553, Japan.
authors.forename: Kazuo
authors.initials: K
authors.lastname: Azuma
authors.affiliation: Koyo Chemical Co. Ltd., 3-11-15 Iidabashi, Chiyodaku, Tokyo 102-0072, Japan.
authors.forename: Seiji
authors.initials: S
authors.lastname: Kurozumi
authors.affiliation: Koyo Chemical Co. Ltd., 3-11-15 Iidabashi, Chiyodaku, Tokyo 102-0072, Japan.
authors.forename: Yoshimori
authors.initials: Y
authors.lastname: Takamori
authors.affiliation: Department of Veterinary Clinical Medicine, School of Veterinary Medicine, Tottori University, 4-101 Koyama-minami, Tottori 680-8553, Japan.
authors.forename: Takeshi
authors.initials: T
authors.lastname: Tsuka
authors.affiliation: Department of Veterinary Clinical Medicine, School of Veterinary Medicine, Tottori University, 4-101 Koyama-minami, Tottori 680-8553, Japan.
authors.forename: Tomohiro
authors.initials: T
authors.lastname: Imagawa
authors.affiliation: Department of Veterinary Clinical Medicine, School of Veterinary Medicine, Tottori University, 4-101 Koyama-minami, Tottori 680-8553, Japan.
authors.forename: Yoshiharu
authors.initials: Y
authors.lastname: Okamoto
authors.affiliation: Department of Veterinary Clinical Medicine, School of Veterinary Medicine, Tottori University, 4-101 Koyama-minami, Tottori 680-8553, Japan.
authors.forename: Saburo
authors.initials: S
authors.lastname: Minami
mesh_terms: D000284:Administration, Oral; D000409:Alanine / Q000097:blood*; D000596:Amino Acids / Q000378:metabolism*; D000693:Anaerobiosis / Q000187:drug effects; D000818:Animals; D002356:Cartilage / Q000378:metabolism; D004285:Dogs; D005650:Fumarates / Q000378:metabolism; D005944:Glucosamine / Q000008:administration & dosage / Q000494:pharmacology*; D019344:Lactic Acid / Q000097:blood*; D055432:Metabolomics; D012038:Regeneration
chemical_list: D000596:Amino Acids; D005650:Fumarates; D019344:Lactic Acid; D005944:Glucosamine; D000409:Alanine