title: C677T methylenetetrahydrofolate reductase gene polymorphism as a risk factor involved in venous thromboembolism: a population-based case-control study.
abstract: The aim of the current study was to investigate the possible correlation             between the C677T methylenetetrahydrofolate reductase (MTHFR) polymorphism and             venous thromboembolism (VTE) in a population-based case-control study. Homocysteine             (Hcy) was quantified by Abbott IMx immunoassay; screening for C677T MTHFR substitution             was performed by polymerase chain reaction (PCR) and restriction analysis. The             results from the two groups (440 patients and 440 controls) revealed that the             frequency of T alleles and TT carriers was significantly higher in patients compared             with that of the healthy controls. The plasma levels of Hcy in the VTE group (13.05±2.37 µmol/l)             were significantly higher compared with those in the control group (11.94±2.03 µmol/l,             P<0.001). The C677T MTHFR polymorphism is suggested to be associated with the             risk for VTE. Plasma levels of Hcy were raised in individuals with the homozygous             MTHFR 677TT genotype. In conclusion, the results of the current study suggest             that hyperhomocysteinemia and the homozygous 677TT MTHFR genotype are risk factors             for VTE.
authors.affiliation: Department of Vascular Surgery, Shandong Provincial Hospital,                     Shandong University, Jinan 250012, P.R. China.
authors.forename: Guancheng
authors.initials: G
authors.lastname: Yin
authors.forename: Liqing
authors.initials: L
authors.lastname: Yan
authors.forename: Zhifeng
authors.initials: Z
authors.lastname: Zhang
authors.forename: Kebiao
authors.initials: K
authors.lastname: Chen
authors.forename: Xing
authors.initials: X
authors.lastname: Jin
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000483:Alleles; D016022:Case-Control Studies; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006710:Homocysteine / Q000097:blood; D006720:Homozygote; D006801:Humans; D020138:Hyperhomocysteinemia / Q000097:blood / Q000473:pathology; D016015:Logistic Models; D008297:Male; D042965:Methylenetetrahydrofolate Reductase (NADPH2) / Q000235:genetics*; D008875:Middle Aged; D016017:Odds Ratio; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors; D012907:Smoking; D054556:Venous Thromboembolism / Q000235:genetics* / Q000473:pathology
chemical_list: D006710:Homocysteine; D042965:Methylenetetrahydrofolate Reductase (NADPH2)