title: Rapid screening and determination of 4-chloroamphetamine in saliva by paper spray-mass spectrometry and capillary electrophoresis-mass spectrometry.
abstract: A novel drug-screening system, consisting of paper spray-MS (PS-MS) and a CE-ESI-MS method was developed. This system can be easily switched either to PS-MS for rapidly screening samples or to the traditional CE-ESI-MS method for separation and to obtain detailed mass spectral information, while sharing the same mass spectrometer. In the former case, when a sharp (15°-tip) chromatography paper was used, the optimized distance from the paper tip to the mass inlet was 7.7 mm, whereas the optimized distance for the CE-ESI tip was ∼13.5 mm. Using 4-chloroamphetamine as a model compound, the LODs for PS-MS and CE-ESI-MS were determined to ∼0.1 and 0.25 ppm, respectively. Comparisons of results obtained using PS-MS and CE-ESI-MS and the experimental conditions are described.
authors.affiliation: Department of Chemistry, National Taiwan Normal University, Taipei, Taiwan.
authors.forename: Chih-Sheng
authors.initials: CS
authors.lastname: Jhang
authors.forename: Hsun
authors.initials: H
authors.lastname: Lee
authors.forename: Yi-San
authors.initials: YS
authors.lastname: He
authors.forename: Ju-Tsung
authors.initials: JT
authors.lastname: Liu
authors.forename: Cheng-Huang
authors.initials: CH
authors.lastname: Lin
mesh_terms: D000662:Amphetamines / Q000032:analysis; D019075:Electrophoresis, Capillary / Q000295:instrumentation / Q000379:methods*; D006801:Humans; D057230:Limit of Detection; D012463:Saliva / Q000737:chemistry*; D021241:Spectrometry, Mass, Electrospray Ionization / Q000295:instrumentation / Q000379:methods*; D015813:Substance Abuse Detection; D010133:p-Chloroamphetamine / Q000032:analysis*
chemical_list: D000662:Amphetamines; D010133:p-Chloroamphetamine; C040639:4-fluoroamphetamine