title: Pharmacokinetics of clopidogrel in healthy Chinese volunteers.
abstract: There are marked ethnic variabilities in the metabolism of clopidogrel. The pharmacokinetic (PK) characteristics of clopidogrel have been studied previously in whites or Korean volunteers, but these PK characteristics may not be fully extrapolated to the Chinese people. Little is known about the PK characteristics of clopidogrel in Chinese population. The aim of this study was to evaluate the pharmacokinetic profiles of clopidogrel in 20 healthy Chinese volunteers after administration of a single dose of clopidogrel 75 mg. The peak plasma concentration (Cmax), time to Cmax (Tmax), area under the plasma concentration versus time curve from time 0 h to 36 h (AUC(0-36)), elimination half-life (t1/2), clearance rate (CL/F) and apparent volume of distribution (Vd) were (1.804 +/- 1.706) ng/ml, (0.7 +/- 0.3) h, (2.465 +/- 1.693) ng x h/ml, (7.3 +/- 7.0) h, (53.09 +/- 34.65) x 10(3) L/h and (447.1 +/- 440.8) x 10(3) L, respectively.
authors.affiliation: Nanjing First Hospital Affiliate To Nanjing Medical University, Nanjing, China.
authors.forename: Jian-Jun
authors.initials: JJ
authors.lastname: Zou
authors.forename: Li
authors.initials: L
authors.lastname: Ding
authors.forename: Jie
authors.initials: J
authors.lastname: Tan
authors.forename: Hong-Wei
authors.initials: HW
authors.lastname: Fan
authors.forename: Guang-Ji
authors.initials: GJ
authors.lastname: Wang
authors.forename: Shao-Liang
authors.initials: SL
authors.lastname: Chen
mesh_terms: D000293:Adolescent; D000328:Adult; D019540:Area Under Curve; D044466:Asian People; D002851:Chromatography, High Pressure Liquid; D000077144:Clopidogrel; D006207:Half-Life; D006801:Humans; D007202:Indicators and Reagents; D008297:Male; D010975:Platelet Aggregation Inhibitors / Q000493:pharmacokinetics*; D011153:Population; D053719:Tandem Mass Spectrometry; D013988:Ticlopidine / Q000031:analogs & derivatives* / Q000493:pharmacokinetics; D055815:Young Adult
chemical_list: D007202:Indicators and Reagents; D010975:Platelet Aggregation Inhibitors; D000077144:Clopidogrel; D013988:Ticlopidine