title: Ingestion of cinnamaldehyde, a TRPA1 agonist, reduces visceral fats in mice fed a high-fat and high-sucrose diet.
abstract: Cinnamaldehyde (CNA), a pungent compound in cinnamon or dried bark of cassia, is a TRPA1 agonist. The effect of 0.1-1.0% CNA on pair-fed mice with high fat and high sucrose (HFS) diet for 1 mo was investigated. The total food intake was similar in the mice fed control and CNA diets, but the body weight showed a tendency to be lower in CNA-fed mice than in control mice. By adding CNA at 0.1, 0.5, and 1.0% concentrations, the weight of the mesenteric adipose tissue decreased significantly, and there was a tendency foward lower perirenal and epididymal adipose tissue weights compared to the control. No differences were found in any blood component measured. UCP1 protein levels in the interscapular brown adipose tissue were higher in the 0.5 and 1.0% CNA groups than in the HSF group, as shown by Western blotting. Collectively, these data show that the addition of CNA diminishes visceral fat deposition in HFS diet-fed mice, in part by stimulating interscapular brown adipose tissue.
authors.affiliation: Graduate School of Nutritional and Environmental Sciences, University of Shizuoka, Shizuoka, Japan.
authors.forename: Yasuko
authors.initials: Y
authors.lastname: Tamura
authors.forename: Yusaku
authors.initials: Y
authors.lastname: Iwasaki
authors.forename: Masataka
authors.initials: M
authors.lastname: Narukawa
authors.forename: Tatsuo
authors.initials: T
authors.lastname: Watanabe
mesh_terms: D000171:Acrolein / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000494:pharmacology; D002001:Adipose Tissue, Brown / Q000378:metabolism*; D000447:Aldehydes / Q000097:blood; D000818:Animals; D001786:Blood Glucose / Q000032:analysis; D015153:Blotting, Western; D001835:Body Weight / Q000502:physiology; D002784:Cholesterol / Q000097:blood; D059305:Diet, High-Fat; D004041:Dietary Fats / Q000008:administration & dosage*; D005227:Fatty Acids / Q000097:blood; D007473:Ion Channels / Q000378:metabolism; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D024101:Mitochondrial Proteins / Q000378:metabolism; D009765:Obesity / Q000378:metabolism*; D009929:Organ Size / Q000502:physiology; D013395:Sucrose / Q000008:administration & dosage*; D000074025:TRPA1 Cation Channel; D050051:Transient Receptor Potential Channels / Q000819:agonists / Q000378:metabolism*; D014280:Triglycerides / Q000097:blood; D000071256:Uncoupling Protein 1
chemical_list: D000447:Aldehydes; D001786:Blood Glucose; D004041:Dietary Fats; D005227:Fatty Acids; D007473:Ion Channels; D024101:Mitochondrial Proteins; D000074025:TRPA1 Cation Channel; D050051:Transient Receptor Potential Channels; D014280:Triglycerides; C475685:Trpa1 protein, mouse; C000604372:Ucp1 protein, mouse; D000071256:Uncoupling Protein 1; C001634:fatty aldehyde; D013395:Sucrose; D000171:Acrolein; D002784:Cholesterol; C012843:cinnamaldehyde