title: Analysis of HLA-DRB3 alleles and supertypical genotypes in the MHC Class II region in sporadic inclusion body myositis.
abstract: We compared the carriage frequencies of HLA-DRB3 and its major alleles and of HLA-DRB4 and HLA-DRB5 in an Australian sIBM cohort and a population control group who had previously been genotyped for the HLA-DRB1*03:01 risk allele. There was a strong disease association with the carriage of the DRB3*01:01 allele which was accounted for by its linkage disequilibrium with DRB1*03:01. The carriage of HLA-DRB4 was found to be strongly protective and abrogated the risk effect of HLA-DRB1*03:01. The findings indicate that haplotypic combinations of alleles at the HLA-DRB1 and secondary HLA-DRB loci have important risk modifying effects in sIBM.
authors.affiliation: Australian Neuro-Muscular Research Institute and Centre for Neuromuscular and Neurological Disorders, The University of Western Australia, Queen Elizabeth II Medical Centre, Perth, Western Australia, Australia.
authors.forename: Arada
authors.initials: A
authors.lastname: Rojana-udomsart
authors.forename: Chalermchai
authors.initials: C
authors.lastname: Mitrpant
authors.forename: Ian
authors.initials: I
authors.lastname: James
authors.forename: Campbell
authors.initials: C
authors.lastname: Witt
authors.forename: Merrilee
authors.initials: M
authors.lastname: Needham
authors.forename: Timothy
authors.initials: T
authors.lastname: Day
authors.forename: Lynette
authors.initials: L
authors.lastname: Kiers
authors.forename: Alastair
authors.initials: A
authors.lastname: Corbett
authors.forename: Patricia
authors.initials: P
authors.lastname: Martinez
authors.forename: Steve D
authors.initials: SD
authors.lastname: Wilton
authors.forename: Frank L
authors.initials: FL
authors.lastname: Mastaglia
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D005260:Female; D005787:Gene Frequency; D005802:Genes, MHC Class II / Q000235:genetics*; D020022:Genetic Predisposition to Disease; D005838:Genotype; D059826:HLA-DRB3 Chains / Q000235:genetics*; D059845:HLA-DRB4 Chains / Q000235:genetics; D059847:HLA-DRB5 Chains / Q000235:genetics; D006801:Humans; D015810:Linkage Disequilibrium; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D018979:Myositis, Inclusion Body / Q000235:genetics*
chemical_list: D059826:HLA-DRB3 Chains; D059845:HLA-DRB4 Chains; D059847:HLA-DRB5 Chains