title: The metastatic cancer cell cortex: an adaptation to enhance robust cell division in novel environments?
abstract: To metastasize, cancer cells must be able to complete cell division in environments very different from their tissue of origin. We suggest that mitotic cell rounding, aided by several actin-regulatory oncogenes, may facilitate this process in a robust, context-independent manner.
authors.affiliation: MRC Laboratory for Molecular Cell Biology, University College London, London, UK. h.matthews@ucl.ac.uk
authors.forename: Helen K
authors.initials: HK
authors.lastname: Matthews
authors.forename: Buzz
authors.initials: B
authors.lastname: Baum
mesh_terms: D000199:Actins / Q000378:metabolism; D000222:Adaptation, Physiological; D000818:Animals; D002455:Cell Division; D003598:Cytoskeletal Proteins / Q000378:metabolism; D006801:Humans; D008565:Membrane Proteins / Q000378:metabolism; D008938:Mitosis; D009362:Neoplasm Metastasis; D009369:Neoplasms / Q000235:genetics / Q000378:metabolism* / Q000473:pathology*; D009857:Oncogenes; D011518:Proto-Oncogene Proteins / Q000378:metabolism; D000099149:Ezrin
chemical_list: D000199:Actins; D003598:Cytoskeletal Proteins; D008565:Membrane Proteins; D011518:Proto-Oncogene Proteins; D000099149:Ezrin; C489850:ECT2 protein, human; C071776:radixin