title: Practical method for the Cu-mediated trifluoromethylation of arylboronic acids with CF3 radicals derived from NaSO2CF3 and tert-butyl hydroperoxide (TBHP).
abstract: A mild and practical protocol for the copper-mediated trifluoromethylation of aryl and heteroaryl boronic acids using NaSO(2)CF(3) (Langlois' reagent) and TBHP is described. The reaction proceeds at room temperature under ambient conditions, and the products can be readily purified by extraction or column chromatography.
authors.affiliation: Department of Chemistry, University of Michigan, 930 North University Avenue, Ann Arbor, Michigan 48109, USA.
authors.forename: Yingda
authors.initials: Y
authors.lastname: Ye
authors.forename: Stefan A
authors.initials: SA
authors.lastname: Künzi
authors.forename: Melanie S
authors.initials: MS
authors.lastname: Sanford
mesh_terms: D001897:Boronic Acids / Q000737:chemistry*; D003300:Copper / Q000737:chemistry*; D005609:Free Radicals / Q000737:chemistry; D007202:Indicators and Reagents / Q000737:chemistry*; D008745:Methylation; D015394:Molecular Structure; D020122:tert-Butylhydroperoxide / Q000737:chemistry*
chemical_list: D001897:Boronic Acids; D005609:Free Radicals; D007202:Indicators and Reagents; D003300:Copper; D020122:tert-Butylhydroperoxide