title: Evaluation of ifosfamide salvage therapy for metastatic canine osteosarcoma.
abstract: A retrospective study was performed to assess toxicity and response rate of ifosfamide salvage treatment for dogs diagnosed with metastatic osteosarcoma (OSA). Dogs diagnosed with OSA and previously treated with standard chemotherapy were included in the study. Nineteen dogs met the inclusion criteria, and 17 dogs were evaluable for response. Ifosfamide doses ranged from 375 to 425 mg m(-2) (median dose 375 mg m(-2)), with a median of two doses administered per dog (range 1-7 doses). The overall response to ifosfamide was 11.8% [complete response (CR) = 1/17, partial response (PR) = 1/17, stable disease (SD) = 2/17, progressive disease (PD) = 13/17]. Two dogs were hospitalized due to ifosfamide toxicosis. The median survival duration from the first dose of ifosfamide to death was 95 days. Ifosfamide was well tolerated, but minor anti-tumour activity was observed.
authors.affiliation: Veterinary Medical Center, Center for Comparative Oncology, Michigan State University, East Lansing, MI, USA.
authors.forename: K
authors.initials: K
authors.lastname: Batschinski
authors.forename: N G
authors.initials: NG
authors.lastname: Dervisis
authors.forename: B E
authors.initials: BE
authors.lastname: Kitchell
mesh_terms: D000671:Amputation, Surgical / Q000662:veterinary; D000818:Animals; D018906:Antineoplastic Agents, Alkylating / Q000494:pharmacology / Q000627:therapeutic use*; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D001859:Bone Neoplasms / Q000188:drug therapy / Q000473:pathology / Q000662:veterinary*; D018572:Disease-Free Survival; D004283:Dog Diseases / Q000188:drug therapy* / Q000473:pathology; D004285:Dogs; D006410:Hematopoiesis; D006811:Humerus / Q000473:pathology; D007069:Ifosfamide / Q000494:pharmacology / Q000627:therapeutic use*; D008824:Michigan; D009362:Neoplasm Metastasis; D012516:Osteosarcoma / Q000188:drug therapy / Q000473:pathology / Q000662:veterinary*; D016016:Proportional Hazards Models; D011884:Radius / Q000473:pathology; D012189:Retrospective Studies; D016879:Salvage Therapy / Q000379:methods / Q000662:veterinary*; D016896:Treatment Outcome
chemical_list: D018906:Antineoplastic Agents, Alkylating; D007069:Ifosfamide