title: Identification of novel splicing variants from RON proto-oncogene pre-mRNA.
abstract: RON is a proto-oncogene that induces cell dissociation, migration and matrix             invasion. RON∆160, a splicing variant of RON, is a natural splicing product in             colon cancers that is produced through skipping of exons 5 and 6 in alternative             splicing process. RON∆160 promotes cellular transformation in vitro and tumor             formation in vivo. We present, here, two novel splicing variants of RON in the             partial splicing events that involve exons 5 and 6. The common facts of these             two novel splicing variants are that exons 4-7 are included. In addition, intron             4 is spliced whereas intron 5 is included in both variants. The difference of             these two isoforms is the inclusion or skipping of intron 6. In one variant intron             6 is included, but intron 6 is skipped in another variant. These two variants             should be truncated but these proteins have not yet been detected.
authors.affiliation: School of Life Sciences, Gwangju Institute of Science and Technology, Gwangju 500-712, Republic of Korea.
authors.forename: Heegyum
authors.initials: H
authors.lastname: Moon
authors.forename: Sunghee
authors.initials: S
authors.lastname: Cho
authors.forename: Xiaoming
authors.initials: X
authors.lastname: Yang
authors.forename: Jianhua
authors.initials: J
authors.lastname: Zhou
authors.forename: Tiing Jen
authors.initials: TJ
authors.lastname: Loh
authors.forename: Xuexiu
authors.initials: X
authors.lastname: Zheng
authors.forename: Haihong
authors.initials: H
authors.lastname: Shen
mesh_terms: D017398:Alternative Splicing; D001483:Base Sequence; D045744:Cell Line, Tumor; D006367:HeLa Cells; D006801:Humans; D007438:Introns; D008969:Molecular Sequence Data; D020033:Protein Isoforms / Q000235:genetics*; D000090063:Proto-Oncogene Mas; D012322:RNA Precursors / Q000235:genetics*; D020794:Receptor Protein-Tyrosine Kinases / Q000235:genetics*
chemical_list: C000715470:MAS1 protein, human; D020033:Protein Isoforms; D000090063:Proto-Oncogene Mas; D012322:RNA Precursors; C080835:RON protein; D020794:Receptor Protein-Tyrosine Kinases