title: A phenolic derivative and two diacetylenes from Symphyotrichum subulatum.
abstract: A pytochemical study on the constituents of the roots of Symphyotrichum subulatum led to the isolation of three new compounds including two diacetylenes, asterynes A (1) and B (2), and (E)-4-(3-acetoxyprop-1-enyl)-2-methoxyphenyl (S)-2-methylbutanoate (3) along with twelve known compounds. Their structures were elucidated with spectroscopic analyses. Compound 3 showed anti-inflammatory activity on LPS-induced NO production with an EC50 value of 15.0 µM.
authors.affiliation: Department of Chemistry, Chinese Culture University, Taipei, Taiwan.
authors.forename: Kai
authors.initials: K
authors.lastname: Lee
authors.forename: Chien-Chang
authors.initials: CC
authors.lastname: Shen
authors.forename: Chwan-Fwu
authors.initials: CF
authors.lastname: Lin
authors.forename: Shyh-Yuan
authors.initials: SY
authors.lastname: Li
authors.forename: Yu-Ling
authors.initials: YL
authors.lastname: Huang
mesh_terms: D000114:Acetylene / Q000031:analogs & derivatives / Q000737:chemistry* / Q000302:isolation & purification* / Q000494:pharmacology; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D019659:Asteraceae / Q000737:chemistry*; D002087:Butyrates / Q000737:chemistry / Q000302:isolation & purification; D004353:Drug Evaluation, Preclinical; D008070:Lipopolysaccharides / Q000009:adverse effects; D008264:Macrophages / Q000737:chemistry / Q000187:drug effects; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D015394:Molecular Structure; D009569:Nitric Oxide / Q000737:chemistry; D019800:Phenol / Q000737:chemistry*; D010636:Phenols / Q000737:chemistry / Q000302:isolation & purification; D010936:Plant Extracts / Q000737:chemistry; D018517:Plant Roots / Q000737:chemistry
chemical_list: C580795:(E)-4-(3-acetoxyprop-1-enyl)-2-methoxyphenyl (S)-2-methylbutanoate; D000894:Anti-Inflammatory Agents, Non-Steroidal; D002087:Butyrates; D008070:Lipopolysaccharides; D010636:Phenols; D010936:Plant Extracts; C580793:asteryne A; D009569:Nitric Oxide; D019800:Phenol; D000114:Acetylene