title: A highly enantioselective synthesis of functionalized 2,3-dihydrofurans by a modified Feist-Bénary reaction.
abstract: Organocatalysis: a modified Feist-Bénary reaction employing acyclic β-ketoesters as the dinucleophile and (E)-β,β-bromo nitrostyrenes as the dielectrophile was developed for the asymmetric synthesis of 2,3-dihydrofurans. L-Threonine-derived tertiary amine/thiourea catalysts were found to be the most efficient catalysts, inducing the reaction in a highly enantioselective manner (TBDPS=tert-butyldiphenylsilyl).
authors.affiliation: Department of Chemistry & Medicinal Chemistry Program, Life Sciences Institute, National University of Singapore, Singapore.
authors.forename: Xiaowei
authors.initials: X
authors.lastname: Dou
authors.forename: Fangrui
authors.initials: F
authors.lastname: Zhong
authors.forename: Yixin
authors.initials: Y
authors.lastname: Lu