title: The Helicobacter pylori cag Pathogenicity Island.
abstract: The cag pathogenicity island is a well-characterized virulence determinant. It is composed of 32 genes that encode a type IV bacterial secretion system and is linked with a more severe clinical outcome. The following chapters will explore the manipulation of bacterial factors in order to understand their role in gastric mucosal disease.
authors.affiliation: Division of Gastroenterology, Department of Medicine, Vanderbilt University Medical Center, MRB IV 1030C MRB IV, Nashville, TN, USA. jennifer.noto@vanderbilt.edu
authors.forename: Jennifer M
authors.initials: JM
authors.lastname: Noto
authors.forename: Richard M
authors.initials: RM
authors.lastname: Peek
mesh_terms: D000942:Antigens, Bacterial / Q000235:genetics* / Q000378:metabolism; D001426:Bacterial Proteins / Q000235:genetics* / Q000378:metabolism; D044404:Genomic Islands; D016480:Helicobacter pylori / Q000235:genetics* / Q000378:metabolism / Q000472:pathogenicity / Q000502:physiology; D006801:Humans; D010457:Peptidoglycan / Q000378:metabolism; D010766:Phosphorylation; D015398:Signal Transduction
chemical_list: D000942:Antigens, Bacterial; D001426:Bacterial Proteins; D010457:Peptidoglycan; C080866:cagA protein, Helicobacter pylori