title: Indium-promoted Reformatsky reaction: a straightforward access to β-amino and β-hydroxy α,α-difluoro carbonyl compounds.
abstract: A versatile and practical methodology to access β-amino and β-hydroxy α,α-difluoro carbonyl compounds using indium metal is described. This methodology has been successfully applied to a broad range of substrates including aldehydes, ketones, and imines, affording the corresponding and highly valuable gem-difluoro esters. The wide substrate scope highlights the chemoselectivity of the process.
authors.affiliation: INSA de Rouen, Avenue de l'Université, 76800 St Etienne du Rouvray, France. thomas.poisson@insa-rouen.fr
authors.forename: Thomas
authors.initials: T
authors.lastname: Poisson
authors.forename: Marie-Charlotte
authors.initials: MC
authors.lastname: Belhomme
authors.forename: Xavier
authors.initials: X
authors.lastname: Pannecoucke
mesh_terms: D000447:Aldehydes / Q000737:chemistry; D006845:Hydrocarbons, Fluorinated / Q000138:chemical synthesis* / Q000737:chemistry; D007097:Imines / Q000737:chemistry; D007204:Indium / Q000737:chemistry*; D007659:Ketones / Q000737:chemistry; D015394:Molecular Structure
chemical_list: D000447:Aldehydes; D006845:Hydrocarbons, Fluorinated; D007097:Imines; D007659:Ketones; D007204:Indium