title: Hospital Outcomes of Adult Respiratory Tract Infections with Extended-Spectrum B-Lactamase (ESBL) Producing Klebsiella Pneumoniae.
abstract: Klebsiella pneumoniae ranks high as a cause of adult pneumonia requiring hospitalization in Malaysia. To study whether extended-spectrum b-lactamase (ESBL) producing K. pneumoniae was linked to hospital outcomes, we retrospectively studied 441 cases of adult respiratory tract infections with microbial proven K. pneumoniae from an urban-based university teaching hospital between 2003 and 2004. 47 (10.6%) cases had ESBL. Requirement for ventilation and median length of hospital stay, were greater in 'ESBL' than in 'non-ESBL' group [34% vs. 7.4%, p<0.001; 14 days vs. 5 days, p<0.001 respectively] but not crude hospital mortality rate [21.3% vs. 12.4%, p=0.092]. There was a four-fold increased risk of requiring ventilation [4.61 (2.72-7.85)] when ESBL was present. Our findings support the association of ESBL producing K. pneumoniae with adversed hospital outcomes and reiterate the need for vigilance on the part of treating clinicians.
authors.affiliation: IMU Lung Research, International Medical University, Kuala Lumpur, Malaysia;
authors.forename: Li-Cher
authors.initials: LC
authors.lastname: Loh
authors.lastname: Nor Izran Hanim Bt Abdul Samad
authors.lastname: Rosdara Masayuni Bt Mohd Sani
authors.forename: Sree
authors.initials: S
authors.lastname: Raman
authors.forename: Tarmizi
authors.initials: T
authors.lastname: Thayaparan
authors.forename: Shalini
authors.initials: S
authors.lastname: Kumar