title: Characterization of the adaptation module of the signaling network in bacterial chemotaxis by measurement of step responses.
abstract: The bacterial chemotaxis network features robust adaptation implemented by negative integral feedback. Here, we show that the adaptation module can be characterized by measurement of the response to simple step-addition and removal of a chemoattractant. The method does not rely on a particular form of the receptor module, and thus can be used to characterize other integral feedback networks.
authors.forename: Junhua
authors.initials: J
authors.lastname: Yuan
authors.forename: Howard C
authors.initials: HC
authors.lastname: Berg
mesh_terms: D000222:Adaptation, Physiological; D002633:Chemotaxis; D004926:Escherichia coli / Q000166:cytology* / Q000378:metabolism / Q000502:physiology*; D008954:Models, Biological; D015398:Signal Transduction