title: Gold nanoparticle enhancement of stereotactic radiosurgery for neovascular age-related macular degeneration.
abstract: Age-related macular degeneration (AMD) is the leading cause of blindness in developed countries for people over the age of 50. In this work, the dosimetric feasibility of using gold nanoparticles (AuNP) as radiosensitizers to enhance kilovoltage stereotactic radiosurgery for neovascular AMD is investigated. Microdosimetry calculations at the sub-cellular level were carried out to estimate the radiation dose enhancement to individual nuclei in neovascular AMD endothelial cells (nDEF) due to photon-induced photo-/Auger electrons from x-ray-irradiated AuNP. The nDEF represents the ratio of radiation doses to the endothelial cell nuclei with and without AuNP. The calculations were carried out for a range of feasible AuNP local concentrations using the clinically applicable 100 kVp x-ray beam parameters employed by a commercially available x-ray therapy system. The results revealed nDEF values of 1.30-3.26 for the investigated concentration range of 1-7 mg g(-1), respectively. In comparison, for the same concentration range, nDEF values of 1.32-3.40, 1.31-3.33, 1.29-3.19, 1.28-3.12 were calculated for 80, 90, 110 and 120 kVp x-rays, respectively. Meanwhile, calculations as a function of distance from the AuNP showed that the dose enhancement, for 100 kVp, is markedly confined to the targeted neovascular AMD endothelial cells where AuNP are localized. These findings provide impetus for considering the application of AuNP to enhance therapeutic efficacy during stereotactic radiosurgery for neovascular AMD.
authors.affiliation: Department of Radiation Oncology, Division of Medical Physics and Biophysics, Brigham and Women's Hospital, Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA 02115, USA. wngwa@lroc.harvard.edu
authors.forename: Wilfred
authors.initials: W
authors.lastname: Ngwa
authors.forename: G Mike
authors.initials: GM
authors.lastname: Makrigiorgos
authors.forename: Ross I
authors.initials: RI
authors.lastname: Berbeco
mesh_terms: D005240:Feasibility Studies; D006046:Gold / Q000737:chemistry* / Q000494:pharmacology*; D006801:Humans; D008268:Macular Degeneration / Q000503:physiopathology* / Q000601:surgery*; D053768:Metal Nanoparticles; D009389:Neovascularization, Pathologic; D011838:Radiation-Sensitizing Agents / Q000737:chemistry / Q000494:pharmacology; D011874:Radiometry; D016634:Radiosurgery / Q000379:methods*
chemical_list: D011838:Radiation-Sensitizing Agents; D006046:Gold