title: Getting stuck in: protein palmitoylation in Plasmodium.
abstract: Palmitoylation is the reversible post-translational addition of a lipid moiety to cysteine residues on targeted proteins. The recent use of proteomic-scale techniques to study protein palmitoylation in multiple organisms has radically changed our understanding of the diversity of proteins and signaling pathways that are affected by palmitoylation. These experiments have made clear that, similarly to phosphorylation, palmitoylation is a regulatory tool that has an impact upon a wide range of essential eukaryotic processes. A recent proteome-level analysis of protein palmitoylation in Plasmodium has revealed the importance of palmitoylation in parasite biology and has raised new and exciting questions about several Plasmodium-specific and virulence-associated processes.
authors.affiliation: Malaria Programme, Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA, UK.
authors.forename: Matthew L
authors.initials: ML
authors.lastname: Jones
authors.forename: Chwen L
authors.initials: CL
authors.lastname: Tay
authors.forename: Julian C
authors.initials: JC
authors.lastname: Rayner
mesh_terms: D000217:Acyltransferases / Q000378:metabolism; D054878:Lipoylation; D010961:Plasmodium / Q000201:enzymology / Q000378:metabolism*; D020543:Proteome; D015800:Protozoan Proteins / Q000235:genetics / Q000378:metabolism*; D013869:Thiolester Hydrolases / Q000378:metabolism
chemical_list: D020543:Proteome; D015800:Protozoan Proteins; D000217:Acyltransferases; D013869:Thiolester Hydrolases