title: Tandem application of C-C bond-forming reactions with reductive ozonolysis.
abstract: Several variants of reductive ozonolysis, defined here as the in situ generation of aldehydes or ketones during ozonolytic cleavage of alkenes, are demonstrated to work effectively in tandem with a number of C-C bond-forming reactions. For reactions involving basic nucleophiles (1,2-addition of Grignard reagents, Wittig or Horner-Emmons olefinations, and directed aldol reactions of lithium enolates), the one-pot process offers a rapid and high-yielding alternative to traditional two-step protocols.
authors.affiliation: Department of Chemistry, University of Nebraska-Lincoln, Lincoln, Nebraska 68588-0304, United States.
authors.forename: Rachel
authors.initials: R
authors.lastname: Willand-Charnley
authors.forename: Patrick H
authors.initials: PH
authors.lastname: Dussault