title: Total synthesis of 7',8'-dihydroaigialospirol.
abstract: A highly convergent total synthesis of 7',8'-dihydroaigialospirol is described. Key steps of the synthesis include a Nozaki-Hiyama-Kishi (NHK) coupling of an iodoalkyne with an advanced phthalide-aldehyde and a remarkable one-pot acid-mediated global deprotection/spiroacetalization.
authors.affiliation: School of Chemical Sciences, The University of Auckland, 23 Symonds Street, Auckland, New Zealand.
authors.forename: Tsz-Ying
authors.initials: TY
authors.lastname: Yuen
authors.forename: Margaret A
authors.initials: MA
authors.lastname: Brimble
mesh_terms: D000447:Aldehydes / Q000737:chemistry; D000475:Alkenes / Q000737:chemistry; D000480:Alkynes / Q000138:chemical synthesis; D001572:Benzofurans / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D013141:Spiro Compounds / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: C579592:7',8'-dihydroaigialospirol; D000447:Aldehydes; D000475:Alkenes; D000480:Alkynes; D001572:Benzofurans; D013141:Spiro Compounds; C082022:phthalide