title: Ophthalmic artery Doppler velocimetric values in pregnant women at risk for preeclampsia.
abstract: OBJECTIVE
  The purposes of this study were to describe ophthalmic artery Doppler parameters in pregnant women at risk for preeclampsia in the second trimester, compare them with reference values described in women with healthy pregnancies, and evaluate the association between gestational age and Doppler parameters.
  
  
  METHODS
  We conducted an observational study with prospective data collection in which measurements of 7 ophthalmic artery Doppler parameters were obtained in 274 women at 20 to 28 weeks' gestation with clinical risk factors for preeclampsia. The following measurements were obtained: peak systolic velocity, mesodiastolic velocity, mean velocity, end-diastolic velocity, resistive index, pulsatility index, and peak ratio. The observed Doppler values were compared with reference values by a 1-sample t test. To test for linear associations between gestational age and Doppler parameters, the Pearson correlation coefficient was used.
  
  
  RESULTS
  Significantly higher ophthalmic artery Doppler velocimetric parameters were observed when compared with the reference values. The mean values of these parameters ± SD were as follows: peak systolic velocity, 37.9 ± 10.3 cm/s (reference, 34.2 cm/s; P < .001); end-diastolic velocity, 7.2 ± 3.1 cm/s (reference, 6.8 cm/s; P = .03); resistive index, 0.81 ± 0.07 (reference, 0.70; P < .001); pulsatility index, 2.17 ± 0.53 (reference, 1.80; P < .001); and peak ratio, 0.53 ± 0.12 (reference, 0.40; P < .001). There was no correlation between the Doppler parameters and gestational age.
  
  
  CONCLUSIONS
  Ophthalmic Doppler parameters of women at risk for preeclampsia are significantly higher than reference values for healthy pregnancies, which may indicate an inadequate vascular response to persistent peripheral resistance. Gestational age during the second trimester is not associated with ophthalmic artery Doppler parameters in pregnant women at risk for preeclampsia.
authors.affiliation: Bahiana School of Medicine and Public Health, Salvador, Bahia, Brazil. dmatias@ultradiag.com.br
authors.forename: Denise S
authors.initials: DS
authors.lastname: Matias
authors.forename: Rigman F
authors.initials: RF
authors.lastname: Costa
authors.forename: Bruno
authors.initials: B
authors.lastname: Matias
authors.forename: Léo
authors.initials: L
authors.lastname: Gordiano
authors.forename: Luis C L
authors.initials: LC
authors.lastname: Correia
mesh_terms: D000293:Adolescent; D000328:Adult; D001938:Brazil / Q000453:epidemiology; D005260:Female; D005865:Gestational Age; D006801:Humans; D015994:Incidence; D008875:Middle Aged; D009880:Ophthalmic Artery / Q000000981:diagnostic imaging*; D011225:Pre-Eclampsia / Q000000981:diagnostic imaging* / Q000453:epidemiology*; D011247:Pregnancy; D015203:Reproducibility of Results; D018570:Risk Assessment; D012680:Sensitivity and Specificity; D012720:Severity of Illness Index; D018608:Ultrasonography, Doppler / Q000379:methods* / Q000706:statistics & numerical data*; D055815:Young Adult