title: Rapid decline in episodic memory in healthy older adults with high amyloid-β.
abstract: High levels of amyloid-β (Aβ) have been associated with greater rates of decline in episodic memory over 18 months in healthy older adults. Serial assessments over shorter time intervals may facilitate earlier detection of Aβ-related memory decline in healthy older adults. In forty-four healthy older adults enrolled in the Australian Imaging, Biomarkers and Lifestyle Rate of Change Sub-Study, we compared rates of change in cognition over six months in healthy older adults with high and low levels of Aβ. High Aβ was associated with greater decline in episodic memory measures over 6 months in healthy older adults.
authors.affiliation: Mental Health Research Institute, The University of Melbourne, Parkville, Vic, Australia. y.lim@mhri.edu.au
authors.forename: Yen Ying
authors.initials: YY
authors.lastname: Lim
authors.forename: Robert H
authors.initials: RH
authors.lastname: Pietrzak
authors.forename: Kathryn A
authors.initials: KA
authors.lastname: Ellis
authors.forename: Judith
authors.initials: J
authors.lastname: Jaeger
authors.forename: Karra
authors.initials: K
authors.lastname: Harrington
authors.forename: Tim
authors.initials: T
authors.lastname: Ashwood
authors.forename: Cassandra
authors.initials: C
authors.lastname: Szoeke
authors.forename: Ralph N
authors.initials: RN
authors.lastname: Martins
authors.forename: Ashley I
authors.initials: AI
authors.lastname: Bush
authors.forename: Colin L
authors.initials: CL
authors.lastname: Masters
authors.forename: Christopher C
authors.initials: CC
authors.lastname: Rowe
authors.forename: Victor L
authors.initials: VL
authors.lastname: Villemagne
authors.forename: David
authors.initials: D
authors.lastname: Ames
authors.forename: David
authors.initials: D
authors.lastname: Darby
authors.forename: Paul
authors.initials: P
authors.lastname: Maruff
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D016229:Amyloid beta-Peptides / Q000097:blood*; D000814:Aniline Compounds; D001315:Australia; D005260:Female; D006801:Humans; D008297:Male; D008569:Memory Disorders / Q000000981:diagnostic imaging / Q000378:metabolism*; D061212:Memory, Episodic; D009483:Neuropsychological Tests; D049268:Positron-Emission Tomography; D011446:Prospective Studies; D013844:Thiazoles
chemical_list: C475519:2-(4'-(methylamino)phenyl)-6-hydroxybenzothiazole; D016229:Amyloid beta-Peptides; D000814:Aniline Compounds; D013844:Thiazoles