title: [Utility of diffusion-weighted magnetic resonance imaging in severe focal traumatic brain injuries].
abstract: OBJECTIVE
  To describe the apparent diffusion coefficient (ADC) in a series of severe traumatic brain injuries, their clinical and outcome features, and possible implications.
  
  
  METHODS
  A descriptive, observational case-series study was carried out.
  
  
  METHODS
  Patients with severe traumatic brain injuries (TBIs) admitted to the ICU were subjected to MRI study using a 1.5 T scanner. Diffusion-weighted images (DWMR) were obtained using the following echo-planar pulse sequence: TR 10000 ms, TE 126.9 ms, with b values 1000 s/mm2 in the three spatial dimensions. Combining the three sets of images, an isotropic image conforming a map of the mean ADCs was obtained.
  
  
  RESULTS
  DWMR was performed in 23 patients with severe TBI admitted to the ICU between 2001 and 2004. In the MR images we selected 26 regions of interest (ROIs) where ADC was recorded. We observed a clear increase in diffusion in non-treated space-occupying lesions versus other types of injuries and the normal values. A poorer outcome was recorded in patients with lower ADC values.
  
  
  CONCLUSIONS
  Mean ADC in the lesions was greater than the normal values and greater in contusions than in other types of injuries, as an expression of extracellular edema. ADCs were decreased in patients with a poor outcome, suggesting an association between ischemia and the patient prognosis.
authors.affiliation: Servicio de Medicina Intensiva, Hospital Santa Bárbara, Puertollano, Ciudad Real, España. fprietom@sescam.jccm.es
authors.forename: F
authors.initials: F
authors.lastname: Prieto-Valderrey
authors.forename: J R
authors.initials: JR
authors.lastname: Muñiz-Montes
authors.forename: J A
authors.initials: JA
authors.lastname: López-García
authors.forename: J
authors.initials: J
authors.lastname: Villegas-Del Ojo
authors.forename: J
authors.initials: J
authors.lastname: Málaga-Gil
authors.forename: R
authors.initials: R
authors.lastname: Galván-García
mesh_terms: D000328:Adult; D001930:Brain Injuries / Q000175:diagnosis*; D038524:Diffusion Magnetic Resonance Imaging; D005260:Female; D006801:Humans; D015601:Injury Severity Score; D008297:Male; D059906:Neuroimaging