title: Fluorescein angiography and retinal vascular development in premature infants.
abstract: OBJECTIVE
  To investigate the role of fluorescein angiography (FA) in the management of retinopathy of prematurity (ROP) in preterm newborns.
  
  
  METHODS
  An observational case series of 13 extremely low birth weight infants. From September 2009 to March 2010, 13 newborn infants with a gestational age <29 weeks end/or birth weight <1000 g underwent serial fluorescein angiography with RetCam (Clarity, Pleasanton, CA) every 2 weeks. The fluorescein angiograms were examined to optimize the timing of diagnosis of ROP and to investigate development of retinal and choroidal vascularization.
  
  
  RESULTS
  There were no side effects related to FA. Variable features of retinal and choroidal circulation in preterm infants with a high risk of developing ROP were noted. FA allows vessels branching at the junction between vascular and avascular retina (V-Av junction) to be viewed easily and shows the ROP findings that sometimes cannot be seen by indirect ophthalmoscopy. Dye leakage is the most significant sign of progression to severe ROP or the need for surgery in newborn babies with ROP.
  
  
  CONCLUSIONS
  RetCam-assisted intravenous FA is safe and allows a more objective assessment of the ROP stage and zone.
authors.affiliation: Department of Paediatrics, Division of Neonatology, Catholic University of Rome, Rome, Italy. veliapurcaro@yahoo.it
authors.forename: Velia
authors.initials: V
authors.lastname: Purcaro
authors.affiliation: Department of Paediatrics, Division of Neonatology, Catholic University of Rome, Rome, Italy. veliapurcaro@yahoo.it
authors.forename: Purcaro
authors.initials: P
authors.lastname: Velia
authors.forename: Antonio
authors.initials: A
authors.lastname: Baldascino
authors.forename: Baldascino
authors.initials: B
authors.lastname: Antonio
authors.forename: Patrizia
authors.initials: P
authors.lastname: Papacci
authors.forename: Papacci
authors.initials: P
authors.lastname: Patrizia
authors.forename: Carmen
authors.initials: C
authors.lastname: Giannantonio
authors.forename: Giannantonio
authors.initials: G
authors.lastname: Carmen
authors.forename: Anna
authors.initials: A
authors.lastname: Molisso
authors.forename: Molisso
authors.initials: M
authors.lastname: Anna
authors.forename: Fernando
authors.initials: F
authors.lastname: Molle
authors.forename: Molle
authors.initials: M
authors.lastname: Fernando
authors.forename: Domenico
authors.initials: D
authors.lastname: Lepore
authors.forename: Lepore
authors.initials: L
authors.lastname: Domenico
authors.forename: Costantino
authors.initials: C
authors.lastname: Romagnoli
authors.forename: Romagnoli
authors.initials: R
authors.lastname: Costantino
mesh_terms: D002829:Choroid / Q000098:blood supply; D005451:Fluorescein Angiography; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature; D009887:Ophthalmoscopy; D012171:Retinal Vessels / Q000196:embryology; D012178:Retinopathy of Prematurity / Q000175:diagnosis* / Q000196:embryology