title: Mathematical modeling of viral infection dynamics in spherical organs.
abstract: A general mathematical model of viral infections inside a spherical organ is presented. Transported quantities are used to represent external cells or viral particles that penetrate the organ surface to either promote or combat the infection. A diffusion mechanism is considered for the migration of transported quantities to the organ inner tissue. Cases that include the effect of penetration, diffusion and proliferation of immune system cells, the generation of latently infected cells and the delivery of antiviral treatment are analyzed. Different antiviral mechanisms are modeled in the context of spatial variation. Equilibrium conditions are also calculated to determine the radial profile after the infection progresses and antiviral therapy is delivered for a long period of time. The dynamic and equilibrium solutions obtained in this paper provide insight into the temporal and spatial evolution of viral infections.
authors.affiliation: Department of Chemical Engineering, The University of Texas at Austin, Austin, TX, 78712, USA, rdunia@che.utexas.edu.
authors.forename: Ricardo
authors.initials: R
authors.lastname: Dunia
authors.forename: Roger
authors.initials: R
authors.lastname: Bonnecaze
mesh_terms: D006801:Humans; D007107:Immune System / Q000821:virology*; D018448:Models, Immunological; D009716:Numerical Analysis, Computer-Assisted; D019562:Viral Load / Q000276:immunology*; D014777:Virus Diseases / Q000276:immunology*; D014780:Viruses / Q000276:immunology*