title: Availability of yttrium-90 from strontium-90: a nuclear medicine perspective.
abstract: Yttrium-90 (T(½) 64.1 hours, E(βmax)=2.28 MeV) is a pure β⁻ particle emitting radionuclide with well-established applications in targeted therapy. There are several advantages of ⁹⁰Y as a therapeutic radionuclide. It has a suitable physical half-life (∼64 hours) and decays to a stable daughter product ⁹⁰Zr by emission of high-energy β⁻ particles. Yttrium has a relatively simple chemistry and its suitability for forming complexes with a variety of chelating agents is well established. The ⁹⁰Sr/⁹⁰Y generator is an ideal source for the long-term continuous availability of no-carrier-added ⁹⁰Y suitable for the preparation of radiopharmaceuticals for radionuclide therapy. The parent radionuclide ⁹⁰Sr, which is a long-lived fission product, is available in large quantities from spent fuel. Several useful technologies have been developed for the preparation of ⁹⁰Sr/⁹⁰Y generators. There are several well-established radiopharmaceuticals based on monoclonal antibodies, peptides, and particulates labeled with ⁹⁰Y, that are in regular use for the treatment of some forms of primary cancers and arthritis. At present, there are no generators for the elution of ⁹⁰Y that can be set up in a hospital radiopharmacy. The radionuclide is procured from manufacturers and the radiopharmaceuticals are formulated on site. This article reviews the development of ⁹⁰Sr/⁹⁰Y generator and the development of ⁹⁰Y radiopharmaceuticals.
authors.affiliation: Radiopharmaceuticals Division, Bhabha Atomic Research Centre, Mumbai, India.
authors.forename: Rubel
authors.initials: R
authors.lastname: Chakravarty
authors.forename: Ashutosh
authors.initials: A
authors.lastname: Dash
authors.forename: M R A
authors.initials: MR
authors.lastname: Pillai
mesh_terms: D006801:Humans; D009683:Nuclear Medicine / Q000379:methods*; D019275:Radiopharmaceuticals / Q000737:chemistry* / Q000627:therapeutic use*; D013326:Strontium Radioisotopes / Q000737:chemistry* / Q000627:therapeutic use*; D015021:Yttrium Radioisotopes / Q000737:chemistry* / Q000627:therapeutic use*
chemical_list: D019275:Radiopharmaceuticals; D013326:Strontium Radioisotopes; D015021:Yttrium Radioisotopes