title: [Vibration perception threshold in diagnosing diabetic peripheral neuropathy by receiver operating characteristic curve].
abstract: OBJECTIVE
  To evaluate the diagnostic value of vibration perception threshold (VPT) in diabetic peripheral neuropathy (DPN) by the receiver operating characteristic curve (ROC) and to establish its cut-off threshold.
  
  
  METHODS
  All patients had the VPT examination and nerve conduction velocity (NCV) examination. NCV examination showed that 283 patients with Type 2 diabetes were divided into a DPN group (n=151) and an NDPN group (n=132). The VPT diagnosis was evaluated by Youden index, sensitivity, specificity and the area under ROC curve. The best cut-off threshold was defined by the Youden index.
  
  
  RESULTS
  1) The NCV was significantly slower, while the VPT was higher in the DPN group than those in the NDPN group (both P values <0.05). 2) The VPT and NCV of both sides of the limb had no difference in all patients. 3) With NCV as the golden diagnosis criterion, the area under ROC of VPT was 0.707, the best cut-off threshold was 10.54 V, the sensitivity was 0.596, the specificity was 0.848, and the Youden index was 0.445. 4) The diagnosis ratio of NCV combined with VPT was 60.4%, significantly higher than that of NCV alone (P<0.05).
  
  
  CONCLUSIONS
  Compared with NCV examination, VPT has good diagnostic value for DPN. The best cut-off value is 10.54 V.
authors.affiliation: Department of Endocrinology, Xiangya Hospital, Central South University, Changsha, China.
authors.forename: Yu
authors.initials: Y
authors.lastname: Hou
authors.forename: Sha
authors.initials: S
authors.lastname: Liu
authors.forename: Tingting
authors.initials: T
authors.lastname: Zhu
authors.forename: Huan
authors.initials: H
authors.lastname: Zhang
authors.forename: Gang
authors.initials: G
authors.lastname: Liu
authors.forename: Yan
authors.initials: Y
authors.lastname: Zhu
authors.forename: Huiling
authors.initials: H
authors.lastname: Chen
mesh_terms: D000328:Adult; D003924:Diabetes Mellitus, Type 2 / Q000150:complications; D003929:Diabetic Neuropathies / Q000175:diagnosis*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009431:Neural Conduction / Q000502:physiology; D010465:Perception; D010523:Peripheral Nervous System Diseases / Q000175:diagnosis*; D012372:ROC Curve; D012684:Sensory Thresholds / Q000502:physiology*; D014732:Vibration