title: Association between interleukin-8 gene -251 T/A polymorphism and the risk of peptic ulcer disease: a meta-analysis.
abstract: It remains controversial regarding the association between interleukin-8 (IL-8) gene -251 T/A polymorphism and peptic ulcer disease (PUD) risk. Thus, a large-scale meta-analysis evaluating the precise association between this gene variant and PUD risk is required. We searched the PubMed, Embase, Web of Science, and Google Scholar until April 25, 2012. Additionally, hand searching of the references of identified articles were performed. All the statistical tests were performed using Stata 11.0. A total of eight studies (3105 subjects) were included in this meta-analysis. Overall, no significant association was found between IL-8 gene -251 T/A polymorphism and PUD risk (for A allele vs. T allele: OR = 1.17, 95% CI = 0.97-1.41, p = 0.094; for A/A vs. T/T: OR = 1.33, 95% CI = 0.94-1.90, p = 0.108; for A/A vs. A/T+T/T: OR = 1.22, 95% CI =0.97-1.52, p = 0.083; for A/A+A/T vs. T/T: OR = 1.26, 95% CI = 0.95-1.67, p = 0.113). However, in the subgroup analyses by ethnicity, H. pylori infection and the subtype of PUD, significant associations were found between IL-8 gene -251 T/A polymorphism and PUD risk in Asians, H. pylori+, duodenal ulcer disease (DUD) and gastric ulcer disease (GUD), respectively. In summary, the present meta-analysis suggests that IL-8 gene -251 T/A polymorphism is associated with increased PUD risk among Asians, and especially for the subgroups of H. pylori+, DUD and GUD.
authors.affiliation: Department of Emergency, Chinese PLA Air Force General Hospital, 30 Fucheng Road, Haidian District, Beijing 100142, China. shuaishuaijita@sohu.com
authors.forename: Yan-Wei
authors.initials: YW
authors.lastname: Yin
authors.forename: Ai-Min
authors.initials: AM
authors.lastname: Hu
authors.forename: Qian-Qian
authors.initials: QQ
authors.lastname: Sun
authors.forename: Bei-Bei
authors.initials: BB
authors.lastname: Zhang
authors.forename: Qi
authors.initials: Q
authors.lastname: Wang
authors.forename: Hong-Li
authors.initials: HL
authors.lastname: Liu
authors.forename: Yi-Hua
authors.initials: YH
authors.lastname: Zeng
authors.forename: Rui-Jia
authors.initials: RJ
authors.lastname: Xu
authors.forename: Shi-Jie
authors.initials: SJ
authors.lastname: Zhang
authors.forename: Long-Bao
authors.initials: LB
authors.lastname: Shi
mesh_terms: D000483:Alleles; D044466:Asian People; D016022:Case-Control Studies; D016206:Databases, Bibliographic; D004381:Duodenal Ulcer / Q000150:complications / Q000208:ethnology / Q000235:genetics* / Q000382:microbiology; D005787:Gene Frequency; D006239:Haplotypes; D016481:Helicobacter Infections / Q000150:complications / Q000208:ethnology / Q000235:genetics* / Q000382:microbiology; D016480:Helicobacter pylori; D006801:Humans; D016209:Interleukin-8 / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D011401:Promoter Regions, Genetic; D012306:Risk; D013276:Stomach Ulcer / Q000150:complications / Q000208:ethnology / Q000235:genetics* / Q000382:microbiology
chemical_list: D016209:Interleukin-8