title: Anti-obesity and hypolipidemic effects of Fuzhuan brick tea water extract in high-fat diet-induced obese rats.
abstract: BACKGROUND
  Fuzhuan brick tea is a kind of microbial fermented tea, which has received increasing attention in recent years owing to its benefits for human health. In this study, the anti-obesity and hypolipidemic effects of Fuzhuan brick tea water extracts (FTEs) were investigated.
  
  
  RESULTS
  FTEs consisted of 204.07 ± 3.38 mg g(-1) polyphenol, 109.20 ± 1.36 mg g(-1) flavonoids, and others. The FTEs significantly suppressed the increase of body weight and accumulation of adipose tissue, and reduced the level of serum triacylglycerol, total cholesterol and low-density lipoprotein (LDL) cholesterol in obese rats fed a high-fat diet. Moreover, FTEs attenuated the gene expression of sterol regulatory element binding protein-1c, fatty acid synthase and CCAAT/enhancer binding protein α, which is related to lipogenic metabolism. In contrast, the gene expressions of enzymes involved in energy expenditure and lipodieresis including hepatic peroxisome proliferator-activated receptor α, carnitine palmitoyltransferase 1a and LDL receptor gene expression were increased by FTE treatment.
  
  
  CONCLUSIONS
  Our study demonstrates that FTEs have anti-obesity and hypolipidemic functions, suggesting that it might be effective for treatment of obesity and hyperlipemia.
authors.affiliation: Key Laboratory of Tea Science of Ministry of Education and Hunan Provincial Key Laboratory of Crop Germplasm Innovation and Utilization, Hunan Agricultural University, Hunan, People's Republic of China.
authors.forename: Qin
authors.initials: Q
authors.lastname: Li
authors.forename: Zhonghua
authors.initials: Z
authors.lastname: Liu
authors.forename: Jianan
authors.initials: J
authors.lastname: Huang
authors.forename: Guoan
authors.initials: G
authors.lastname: Luo
authors.forename: Qionglin
authors.initials: Q
authors.lastname: Liang
authors.forename: Die
authors.initials: D
authors.lastname: Wang
authors.forename: Xiaoyan
authors.initials: X
authors.lastname: Ye
authors.forename: Chaobi
authors.initials: C
authors.lastname: Wu
authors.forename: Lili
authors.initials: L
authors.lastname: Wang
authors.forename: Jiehui
authors.initials: J
authors.lastname: Hu
mesh_terms: D000273:Adipose Tissue / Q000378:metabolism*; D000818:Animals; D019440:Anti-Obesity Agents / Q000494:pharmacology / Q000627:therapeutic use*; D028241:Camellia sinensis / Q000737:chemistry*; D059305:Diet, High-Fat / Q000009:adverse effects; D004041:Dietary Fats / Q000008:administration & dosage / Q000009:adverse effects / Q000378:metabolism; D004734:Energy Metabolism / Q000187:drug effects / Q000235:genetics; D005285:Fermentation; D015870:Gene Expression / Q000187:drug effects; D006949:Hyperlipidemias / Q000209:etiology / Q000235:genetics / Q000378:metabolism / Q000517:prevention & control*; D000960:Hypolipidemic Agents / Q000494:pharmacology / Q000627:therapeutic use*; D050356:Lipid Metabolism / Q000235:genetics; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D008297:Male; D009765:Obesity / Q000209:etiology / Q000235:genetics / Q000378:metabolism / Q000517:prevention & control*; D047493:PPAR alpha / Q000235:genetics / Q000378:metabolism; D008517:Phytotherapy; D028321:Plant Preparations / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use; D059808:Polyphenols / Q000032:analysis / Q000494:pharmacology / Q000627:therapeutic use; D051381:Rats; D017207:Rats, Sprague-Dawley; D015430:Weight Gain / Q000187:drug effects*
chemical_list: D019440:Anti-Obesity Agents; D004041:Dietary Fats; D000960:Hypolipidemic Agents; D047493:PPAR alpha; D028321:Plant Preparations; D059808:Polyphenols