title: Meta-analysis confirms that a  common  G/C variant in the pre-miR-146a gene contributes to cancer susceptibility and that ethnicity, gender and smoking status are risk factors.
abstract: Evidence  has shown that miR-146a is involved in carcinogenesis, and a common G/C variant  (rs2910164) in the pre-miR-146a gene has been associated with various  types of cancer. We summarized the data from 22 published case-control studies  on the association between rs2910164 and cancer risk and performed subgroup  analyses by ethnicity, gender and smoking status. We found a significant  association between the pre-miR-146a polymorphism and cancer risk in  Caucasian populations (odds ratio (OR) = 0.93, 95% confidence interval (CI) =  0.88-0.99 for G- vs C-allele), while the significance was borderline in  Asian populations (OR = 1.11, 95%CI = 1.00-1.23 for G- vs C-allele). A  significantly increased risk of cancer was found in males with GG/GC genotypes  (OR = 1.23, 95%CI = 1.10- 1.37), and the significance was more pronounced in  smokers (OR = 1.82, 95%CI = 1.32-2.51) than in non-smokers (OR = 1.24, 95%CI =  1.01-1.53). We conclude that there is evidence that the pre-miR-146a polymorphism  contributes to cancer susceptibilities and that gender and smoking status  affect the probability of cancer in individuals with this polymorphism.
authors.affiliation: Department of Urology, JingDu Hospital of Nanjing, Nanjing, China.
authors.forename: A-X
authors.initials: AX
authors.lastname: Wang
authors.forename: B
authors.initials: B
authors.lastname: Xu
authors.forename: N
authors.initials: N
authors.lastname: Tong
authors.forename: S-Q
authors.initials: SQ
authors.lastname: Chen
authors.forename: Y
authors.initials: Y
authors.lastname: Yang
authors.forename: X-W
authors.initials: XW
authors.lastname: Zhang
authors.forename: H
authors.initials: H
authors.lastname: Jiang
authors.forename: N
authors.initials: N
authors.lastname: Liu
authors.forename: J
authors.initials: J
authors.lastname: Liu
authors.forename: X-N
authors.initials: XN
authors.lastname: Hu
authors.forename: G-Z
authors.initials: GZ
authors.lastname: Sha
authors.forename: M
authors.initials: M
authors.lastname: Chen
mesh_terms: D016022:Case-Control Studies; D005260:Female; D005787:Gene Frequency / Q000235:genetics; D020022:Genetic Predisposition to Disease; D006801:Humans; D008297:Male; D035683:MicroRNAs / Q000235:genetics*; D008957:Models, Genetic; D009369:Neoplasms / Q000208:ethnology* / Q000235:genetics*; D016017:Odds Ratio; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D017594:Publication Bias; D012322:RNA Precursors / Q000235:genetics; D012307:Risk Factors; D012727:Sex Characteristics; D012907:Smoking / Q000235:genetics*
chemical_list: C542542:MIRN146 microRNA, human; D035683:MicroRNAs; D012322:RNA Precursors