title: Efficient control of pandemic 2009 H1N1 virus infection with intravenous zanamivir despite the lack of immune function.
abstract: A teenager who acquired 2009 H1N1 influenza A lower respiratory tract infection during total bone marrow and lymphoid aplasia, in the setting of human leukocyte antigen-haploidentical hematopoietic stem cell transplantation, was successfully treated with intravenous zanamivir. This case demonstrates efficient control of pandemic influenza infection by intravenous zanamivir in the absence of any functional immune system, thus suggesting profound antiviral activity.
authors.affiliation: Department of Pediatric Oncology, Hematology and Clinical Immunology, Center for Child and Adolescent Health, Medical Faculty, Heinrich-Heine-Universität, Düsseldorf, Germany. sujal.ghosh@med.uni-duesseldorf.de
authors.forename: S
authors.initials: S
authors.lastname: Ghosh
authors.forename: O
authors.initials: O
authors.lastname: Adams
authors.forename: F R
authors.initials: FR
authors.lastname: Schuster
authors.forename: A
authors.initials: A
authors.lastname: Borkhardt
authors.forename: R
authors.initials: R
authors.lastname: Meisel
mesh_terms: D000293:Adolescent; D000970:Antineoplastic Agents / Q000009:adverse effects / Q000627:therapeutic use; D000998:Antiviral Agents / Q000627:therapeutic use; D005260:Female; D018380:Hematopoietic Stem Cell Transplantation / Q000009:adverse effects*; D006801:Humans; D016867:Immunocompromised Host; D053118:Influenza A Virus, H1N1 Subtype; D007251:Influenza, Human / Q000188:drug therapy* / Q000821:virology; D058873:Pandemics; D053243:Zanamivir / Q000627:therapeutic use*
chemical_list: D000970:Antineoplastic Agents; D000998:Antiviral Agents; D053243:Zanamivir