title: Severe anaphylaxis caused by orally administered vancomycin to a patient with Clostridium difficile infection.
abstract: We report the first case of anaphylaxis to oral vancomycin in a cystic fibrosis patient with severe and relapsing Clostridium difficile infection (CDI) refractory to metronidazole. The patient's colitis has been successfully treated with a combination of intravenous metronidazole and tigecycline.
authors.affiliation: Department of Medicine, Faculty of Medicine and Health Sciences, University of Sherbrooke, Sherbrooke, QC, Canada. dominick.bosse@usherbrooke.ca
authors.forename: D
authors.initials: D
authors.lastname: Bossé
authors.forename: C
authors.initials: C
authors.lastname: Lemire
authors.forename: J
authors.initials: J
authors.lastname: Ruel
authors.forename: A M
authors.initials: AM
authors.lastname: Cantin
authors.forename: F
authors.initials: F
authors.lastname: Ménard
authors.forename: L
authors.initials: L
authors.lastname: Valiquette
mesh_terms: D000284:Administration, Oral; D000328:Adult; D000707:Anaphylaxis / Q000139:chemically induced*; D000900:Anti-Bacterial Agents / Q000009:adverse effects* / Q000627:therapeutic use; D016360:Clostridioides difficile; D003015:Clostridium Infections / Q000188:drug therapy*; D003550:Cystic Fibrosis / Q000150:complications; D003967:Diarrhea / Q000382:microbiology; D004761:Enterocolitis, Pseudomembranous / Q000188:drug therapy; D006801:Humans; D008297:Male; D008795:Metronidazole / Q000627:therapeutic use; D008911:Minocycline / Q000031:analogs & derivatives / Q000627:therapeutic use; D012720:Severity of Illness Index; D000078304:Tigecycline; D014640:Vancomycin / Q000009:adverse effects*
chemical_list: D000900:Anti-Bacterial Agents; D008795:Metronidazole; D014640:Vancomycin; D000078304:Tigecycline; D008911:Minocycline