title: Altered θ coupling between medial entorhinal cortex and dentate gyrus in temporal lobe epilepsy.
abstract: OBJECTIVE
  Temporal lobe epilepsy is often accompanied by neuron loss and rewiring in the hippocampus. We hypothesized that the interaction of subnetworks of the entorhinal-hippocampal loop between epileptic events should show significant signatures of these pathologic changes.
  
  
  METHODS
  We combined simultaneous recording of local field potentials in entorhinal cortex (EC) and dentate gyrus (DG) in freely behaving kainate-injected mice with histologic analyses and computational modeling.
  
  
  RESULTS
  In healthy mice, theta band activity was synchronized between EC and DG. In contrast, in epileptic mice, theta activity in the EC was delayed with respect to the DG. A computational neural mass model suggests that hippocampal cell loss imbalances the coupling of subnetworks, introducing the shift.
  
  
  CONCLUSIONS
  We show that pathologic dynamics in epilepsy encompass ongoing activity in the entorhinal-hippocampal loop beyond acute epileptiform activity. This predominantly affects theta band activity, which links this shift in entorhinal-hippocampal interaction to behavioral aspects in epilepsy.
authors.affiliation: Bernstein Center Freiburg, University of Freiburg, Freiburg, Germany.
authors.forename: Ulrich P
authors.initials: UP
authors.lastname: Froriep
authors.forename: Arvind
authors.initials: A
authors.lastname: Kumar
authors.forename: Delphine
authors.initials: D
authors.lastname: Cosandier-Rimélé
authors.forename: Ute
authors.initials: U
authors.lastname: Häussler
authors.forename: Antje
authors.initials: A
authors.lastname: Kilias
authors.forename: Carola A
authors.initials: CA
authors.lastname: Haas
authors.forename: Ulrich
authors.initials: U
authors.lastname: Egert
mesh_terms: D000818:Animals; D018891:Dentate Gyrus / Q000473:pathology / Q000502:physiology*; D018728:Entorhinal Cortex / Q000473:pathology / Q000502:physiology*; D004833:Epilepsy, Temporal Lobe / Q000473:pathology / Q000503:physiopathology*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D013826:Theta Rhythm / Q000502:physiology*