title: Antioxidant activity of indole-based melatonin analogues in erythrocytes and their voltammetric characterization.
abstract: Melatonin (MLT) is a strong free-radical scavenger, which protects the body from the effects of oxidants. In recent years, MLT have been described resulting in much attention in the development of synthetic compounds possessing. As a part of our ongoing study a series of indole-based MLT analogue hydrazide/hydrazone derivatives were synthesized, characterized and in vitro antioxidant activity was investigated by evaluating their reducing effect against oxidation of a redox sensitive fluorescent probe. Membrane stabilizing effect of all compounds was also investigated by lactate dehydrogenase leakage assay. Furthermore voltammetric methods have been applied to the synthesized compounds to characterize oxidation potentials to get insight into their metabolism owing to the oxidation mechanisms taking place at the electrode and in the body share similar principles.
authors.affiliation: Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Ankara University , Tandogan, Ankara , Turkey.
authors.forename: Sibel
authors.initials: S
authors.lastname: Suzen
authors.forename: Betul
authors.initials: B
authors.lastname: Tekiner-Gulbas
authors.forename: Hanif
authors.initials: H
authors.lastname: Shirinzadeh
authors.forename: Duysal
authors.initials: D
authors.lastname: Uslu
authors.forename: Hande
authors.initials: H
authors.lastname: Gurer-Orhan
authors.forename: Mehmet
authors.initials: M
authors.lastname: Gumustas
authors.forename: Sibel Aysil
authors.initials: SA
authors.lastname: Ozkan
mesh_terms: D000975:Antioxidants / Q000138:chemical synthesis / Q000737:chemistry* / Q000378:metabolism*; D055664:Electrochemical Techniques; D004566:Electrodes; D004912:Erythrocytes / Q000737:chemistry* / Q000378:metabolism; D005456:Fluorescent Dyes; D006801:Humans; D006836:Hydro-Lyases / Q000378:metabolism; D007211:Indoles / Q000737:chemistry*; D008550:Melatonin / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry / Q000378:metabolism*; D015394:Molecular Structure
chemical_list: D000975:Antioxidants; D005456:Fluorescent Dyes; D007211:Indoles; C030374:indole; D006836:Hydro-Lyases; C045581:lactate dehydratase; D008550:Melatonin