title: Incidence of viral respiratory pathogens causing exacerbations in adult cystic fibrosis patients.
abstract: Respiratory infections caused by respiratory viruses are common in paediatric cystic fibrosis (CF) patients and are associated with increased morbidity. There is only little data on the incidence of viral respiratory pathogens causing exacerbations in the adult CF patient population. In this observational pilot study we show, by using molecular as well as conventional techniques for viral isolation, that during 1 y a viral pathogen could be isolated in 8/24 (33%) adult CF patients who presented with a pulmonary exacerbation. This result shows that there is a considerable incidence of viral pathogens in pulmonary exacerbations in adult CF patients. Newly identified viruses such as pandemic influenza A/H1N1, human metapneumovirus, human bocavirus, and human coronavirus NL63 were not detected in our population, except for 1 human coronavirus NL63.
authors.affiliation: Department of Pulmonary Medicine, Erasmus MC Rotterdam, Rotterdam, the Netherlands.
authors.forename: Rogier A S
authors.initials: RA
authors.lastname: Hoek
authors.forename: Marthe S
authors.initials: MS
authors.lastname: Paats
authors.forename: Suzan D
authors.initials: SD
authors.lastname: Pas
authors.forename: Marleen
authors.initials: M
authors.lastname: Bakker
authors.forename: Henk C
authors.initials: HC
authors.lastname: Hoogsteden
authors.forename: Charles A B
authors.initials: CA
authors.lastname: Boucher
authors.forename: Menno M
authors.initials: MM
authors.lastname: van der Eerden
mesh_terms: D000328:Adult; D003550:Cystic Fibrosis / Q000821:virology*; D005260:Female; D006801:Humans; D015994:Incidence; D053118:Influenza A Virus, H1N1 Subtype / Q000235:genetics / Q000302:isolation & purification; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D012141:Respiratory Tract Infections / Q000821:virology*; D013183:Sputum / Q000821:virology; D014777:Virus Diseases / Q000150:complications* / Q000821:virology; D014780:Viruses / Q000235:genetics / Q000302:isolation & purification