title: High parathyroid hormone, but not low vitamin D concentrations, expose elderly inpatients to hypertension.
abstract: OBJECTIVE
  Serum parathyroid hormone (PTH) and 25-hydroxyvitamin D (25OHD) concentrations might contribute to blood pressure (BP) levels. Mixed results in previous literature could be due to the failure to consider both these hormones concurrently, despite their long-known relationship. Our objective was to examine the association of serum intact PTH and 25OHD concentrations with BP levels amongst older inpatients, while accounting for each other.
  
  
  METHODS
  The participants were 284 Caucasian older inpatients with no suspicion of primary hyperparathyroidism (mean age 85.87 ± 5.90 years; 65.8% female) admitted to the geriatric acute care unit of Angers University Hospital, France. They were divided into two groups according to the existence of hypertension (i.e. systolic blood pressure [SBP] >140 mmHg, or diastolic blood pressure [DBP] >90 mmHg). Age, sex, numbers of chronic diseases and of drugs taken daily, use of antihypertensive or corticosteroid drugs and of calcium supplements/vitamin D, thyroid-stimulating hormone and albumin concentrations, creatinine clearance, and season tested were used as covariables.
  
  
  RESULTS
  Hypertensive participants (n=106) had higher intact PTH concentrations than normotensive patients (P=0.044). There was a positive linear association of BP with intact PTH concentrations (adjusted β=0.08, P=0.015 for SBP; adjusted β=0.05, P=0.044 for DBP), but not with vitamin D. Serum intact PTH concentration, unlike 25OHD, was associated with hypertension (adjusted OR 1.01, P=0.038).
  
  
  CONCLUSIONS
  Irrespective of 25OHD, PTH was associated with hypertension by increasing both SBP and DBP.
authors.affiliation: Department of Neuroscience, Division of Geriatric Medicine, Angers University Hospital Angers University Memory Clinic UPRES EA 2646 University of Angers, Angers Cedex 9, France.
authors.forename: Leyla
authors.initials: L
authors.lastname: Mateus-Hamdan
authors.forename: Olivier
authors.initials: O
authors.lastname: Beauchet
authors.forename: Béatrice
authors.initials: B
authors.lastname: Bouvard
authors.forename: Erick
authors.initials: E
authors.lastname: Legrand
authors.forename: Bruno
authors.initials: B
authors.lastname: Fantino
authors.forename: Cédric
authors.initials: C
authors.lastname: Annweiler
mesh_terms: D000369:Aged, 80 and over; D015415:Biomarkers / Q000097:blood; D001794:Blood Pressure / Q000502:physiology*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D006973:Hypertension / Q000097:blood* / Q000503:physiopathology; D007297:Inpatients; D008297:Male; D010281:Parathyroid Hormone / Q000097:blood*; D012189:Retrospective Studies; D014807:Vitamin D / Q000097:blood*
chemical_list: D015415:Biomarkers; D010281:Parathyroid Hormone; D014807:Vitamin D