title: [Adaptation to hypoxia and hyperoxia improves physical endurance: the role of reactive oxygen species and redox-signaling].
abstract: We have conducted theoretical foundation, experimental analysis and a pilot study of a new method of adaptation to hypoxia and hyperoxia in the prevention of hypoxic and stress-induced disorders and improving the body's tolerance to physical stress. It has been shown in the experimental part that a combination of physical exercise with adaptation to hypoxia-hyperoxia significantly increased tolerance to acute physical load (APL) and its active phase. Analysis of lipid peroxidation processes, antioxidant enzymes and HSPs showed that short-term training for physical exercise by itself compensates the stressor, but not the hypoxic component of the APL, the combination of training with adaptation to hypoxia-hyperoxia completely normalizes the stressor and hypoxic components of APL. The pilot study has been performed to evaluate the effectiveness of hypoxic-hyperoxic training course in qualified young athletes with over-training syndrome. After completing the course of hypoxia-hyperoxia adaptation, 14 sessions, accompanied by light mode sports training, the athletes set the normalization of autonomic balance, increased resistance to acute hypoxia in hypoxic test, increased physical performance--increased PWC170, maximal oxygen consumption (VO2max) parameters, their relative values to body mass, diminished shift of rate pressure product in the load. Thus, we confirmed experimental findings that hypoxic-hyperoxic training optimizes hypoxic (increased athletes resistance to proper hypoxia) and stress (myocardium economy in acute physical stress testing) components in systemic adaptation and restoration of athletes' with over-training syndrome.
authors.forename: T G
authors.initials: TG
authors.lastname: Sazontova
authors.forename: O S
authors.initials: OS
authors.lastname: Glazachev
authors.forename: A V
authors.initials: AV
authors.lastname: Bolotova
authors.forename: E N
authors.initials: EN
authors.lastname: Dudnik
authors.forename: N V
authors.initials: NV
authors.lastname: Striapko
authors.forename: I V
authors.initials: IV
authors.lastname: Bedareva
authors.forename: N A
authors.initials: NA
authors.lastname: Anchishkina
authors.forename: Iu V
authors.initials: IuV
authors.lastname: Arkhipenko
mesh_terms: D000064:Acclimatization / Q000187:drug effects* / Q000502:physiology; D000818:Animals; D000975:Antioxidants / Q000378:metabolism; D056352:Athletes; D015444:Exercise; D005080:Exercise Test; D015870:Gene Expression; D006360:Heat-Shock Proteins / Q000235:genetics / Q000378:metabolism; D006801:Humans; D018496:Hyperoxia / Q000378:metabolism*; D000860:Hypoxia / Q000378:metabolism*; D015227:Lipid Peroxidation / Q000187:drug effects; D010084:Oxidation-Reduction; D010100:Oxygen / Q000378:metabolism / Q000494:pharmacology*; D010101:Oxygen Consumption / Q000502:physiology; D010807:Physical Endurance / Q000187:drug effects* / Q000502:physiology; D051381:Rats; D017208:Rats, Wistar; D017382:Reactive Oxygen Species / Q000378:metabolism; D015398:Signal Transduction / Q000187:drug effects
chemical_list: D000975:Antioxidants; D006360:Heat-Shock Proteins; D017382:Reactive Oxygen Species; D010100:Oxygen