title: [Lesions in the nervous system during chemotherapy of acute leukosis and non-Hodgkin lymphomas].
abstract: We studied lesions in the nervous system of 60 patients with acute leukosis and 25 with non-Hodgkin lymphomas during standard chemotherapy. Toxic encephalopathy was diagnosed in 6 (10%) patients with acute leucosis treated by endolumbal administration of metotherxate, cytarabine and prednisolone (to prevent neuroleukemia) and in 2 (8%) patients with non-Hodgkin lymphomas. 5 (8.3%) patients with acute leukosis and 5 (20%) with non-Hodgkin lymphomas suffered polyneuropathy after vincristine therapy. Acute disturbance of cerebral circulation was documented in 17 (28.3%) patients with acute leucosis.
authors.forename: G V
authors.initials: GV
authors.lastname: Zyrina
mesh_terms: D000208:Acute Disease; D000328:Adult; D000368:Aged; D000970:Antineoplastic Agents / Q000009:adverse effects*; D003561:Cytarabine / Q000009:adverse effects; D004359:Drug Therapy, Combination / Q000009:adverse effects; D005260:Female; D006801:Humans; D007938:Leukemia / Q000188:drug therapy*; D008228:Lymphoma, Non-Hodgkin / Q000188:drug therapy* / Q000473:pathology; D008297:Male; D008727:Methotrexate / Q000009:adverse effects; D008875:Middle Aged; D011239:Prednisolone / Q000009:adverse effects; D014750:Vincristine / Q000009:adverse effects
chemical_list: D000970:Antineoplastic Agents; D003561:Cytarabine; D014750:Vincristine; D011239:Prednisolone; D008727:Methotrexate