title: [Relationship between mannose-binding protein gene polymorphisms and disease progression and HBV DNA in patients with chronic HBV infection].
abstract: OBJECTIVE
  To determine the influences of Mannose binding protein (MBP) gene polymorphisms on HBV DNA loads and on the progression of liver disease in patients with chronic HBV infection.
  
  
  METHODS
  The Codons on 54 MBP gene polymorphisms and HBV DNA loads in a cohort of 395 patients with chronic HBV infection, including 244 with chronic hepatitis B (CHB), 151 with liver cirrhosis (LC) and 88 normal controls were examined by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) and fluorescent quantitative PCR (FQ-PCR).
  
  
  RESULTS
  The MBP genotype frequencies of GGC/GAC and alleles genetic frequencies of GAC in CHB group showed no significant differences comparing to the normal control group (P > 0.05). The MBP genotype frequencies of GGC/GAC and alleles genetic frequencies of GAC on CHB group (severe), compensation phase of LC group and decompensation phase of LC group were higher than those in the normal control group (P < 0.05), the genetic polymorphism of decompensation of LC was 36.5%, highest of all. The MBP genotype frequencies of GGC/GAC and alleles genetic frequencies of GAC of patients with chronic HBV infection were not changed with the differences of HBV-DNA loads.
  
  
  CONCLUSIONS
  The codes on 54 MBP gene polymorphisms is not closely related to HBV DNA loads, but was associated with the progression of hepatitis B infection.
authors.affiliation: Research and Therapy Center for Liver Diseases, Dongnan Affiliated Hospital of Xiamen University, Zhang Zhou 363000, China. zhengruidan@tom.com
authors.forename: Rui-Dan
authors.initials: RD
authors.lastname: Zheng
authors.forename: Jian-Neng
authors.initials: JN
authors.lastname: Chen
authors.forename: Jian-Ping
authors.initials: JP
authors.lastname: Gao
authors.forename: Qun-Ying
authors.initials: QY
authors.lastname: Zhuang
authors.forename: Qing-Chuan
authors.initials: QC
authors.lastname: Zhu
authors.forename: Yan-Hui
authors.initials: YH
authors.lastname: Lu
authors.forename: Zhen-Qun
authors.initials: ZQ
authors.lastname: Lin
authors.forename: Wu-Hua
authors.initials: WH
authors.lastname: Hong
authors.forename: Qing-Duan
authors.initials: QD
authors.lastname: Li
authors.forename: Zhe
authors.initials: Z
authors.lastname: Chen
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D015331:Cohort Studies; D004279:DNA, Viral / Q000032:analysis*; D018450:Disease Progression; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D019694:Hepatitis B, Chronic / Q000235:genetics*; D006801:Humans; D008297:Male; D037601:Mannose-Binding Lectin / Q000235:genetics*; D008875:Middle Aged; D011110:Polymorphism, Genetic
chemical_list: D004279:DNA, Viral; D037601:Mannose-Binding Lectin