title: Acremomannolipin A, the potential calcium signal modulator with a characteristic glycolipid structure from the filamentous fungus Acremonium strictum.
abstract: By the newly developed assay method, the glycolipid Acremomannolipin A (1) was isolated from a filamentous fungus Acremonium strictum as a potential calcium signal modulator. The structure of 1 elucidated on the basis of intensive spectroscopic analyses as well as its degradation studies is quite unique: the d-mannopyranose is connected to d-mannitol through a β-glycoside linkage; all the hydroxyls in the mannose are highly masked as peresters with aliphatic acids, and this moiety is made hydrophobic, whereas the mannitol part exhibits a highly hydrophilic property. The compound (1) showed the characteristic bioactivity property, enabling calcineurin deletion cells to grow in the presence of Cl(-), which would be caused by calcium signal modulating. The activity was so potent as to exert the effect at a concentration of 200 nM.
authors.affiliation: Laboratory of Molecular Pharmacogenomics, School of Pharmacy, Kinki University, 3-4-1 Kowakae, Higashi-Osaka, Osaka 577-8502, Japan. sugiurar@phar.kindai.ac.jp
authors.forename: Reiko
authors.initials: R
authors.lastname: Sugiura
authors.forename: Ayako
authors.initials: A
authors.lastname: Kita
authors.forename: Nozomi
authors.initials: N
authors.lastname: Tsutsui
authors.forename: Osamu
authors.initials: O
authors.lastname: Muraoka
authors.forename: Kanako
authors.initials: K
authors.lastname: Hagihara
authors.forename: Nanae
authors.initials: N
authors.lastname: Umeda
authors.forename: Tatsuki
authors.initials: T
authors.lastname: Kunoh
authors.forename: Hirofumi
authors.initials: H
authors.lastname: Takada
authors.forename: Dai
authors.initials: D
authors.lastname: Hirose
mesh_terms: D000164:Acremonium / Q000737:chemistry*; D002118:Calcium / Q000378:metabolism; D020013:Calcium Signaling / Q000187:drug effects; D005658:Fungi / Q000737:chemistry*; D006017:Glycolipids / Q000737:chemistry* / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure
chemical_list: D006017:Glycolipids; C579014:acremomannolipin A; D002118:Calcium