title: Intraoperative intravenous lidocaine reduces hospital length of stay following open gastrectomy for stomach cancer in men.
abstract: OBJECTIVE
  To evaluate whether intraoperative low-dose lidocaine infusion decreases postoperative analgesic consumption, ileus, and duration of hospital stay.
  
  
  METHODS
  Prospective, randomized, double-blinded trial.
  
  
  METHODS
  Operating room in a university hospital.
  
  
  METHODS
  48 ASA physical status 1 and 2 men scheduled for subtotal gastrectomy.
  
  
  METHODS
  Patients were randomly allocated to two groups to receive either intravenous (IV) lidocaine 1.5 mg/kg 20 minutes before incision followed by a continuous lidocaine infusion of 1.5 mg/kg/hr until the end of surgery (lidocaine group) or saline in a similar manner (control group).
  
  
  METHODS
  Outcomes such as pain intensity, postoperative analgesic consumption, duration of ileus, and hospital length of stay (LOS) were recorded.
  
  
  RESULTS
  There were no differences in total consumption of IV patient-controlled analgesia (IVPCA) or pain scores at 24, 48, or 72 hours postoperatively. However, lidocaine group patients had significantly decreased average supplemental pethidine requirement per patient for pain control until 72 hours postoperatively [150 (75-200) mg vs 50 (50-150) mg, P = 0.039] and hospital LOS (9.5 ± 3 d vs 8.7 ± 1 d, P = 0.006, 95% CI: - 0.3 - 1.9 d) than control group patients. However, no differences were noted between the groups in pain intensity or duration of ileus.
  
  
  CONCLUSIONS
  Intraoperative IV low-dose lidocaine infusion decreased opioid consumption and hospital LOS after gastrectomy.
authors.affiliation: Department of Anesthesiology and Pain Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, 50 Ilwon-dong, Kangnam-ku, Seoul, Korea.
authors.forename: Jin Gu
authors.initials: JG
authors.lastname: Kang
authors.forename: Myung Hee
authors.initials: MH
authors.lastname: Kim
authors.forename: Eun Hee
authors.initials: EH
authors.lastname: Kim
authors.forename: Sang Hyun
authors.initials: SH
authors.lastname: Lee
mesh_terms: D000701:Analgesics, Opioid / Q000008:administration & dosage / Q000627:therapeutic use; D000779:Anesthetics, Local / Q000008:administration & dosage / Q000627:therapeutic use; D004311:Double-Blind Method; D005743:Gastrectomy / Q000379:methods*; D006760:Hospitalization / Q000706:statistics & numerical data; D006785:Hospitals, University; D006801:Humans; D045823:Ileus / Q000453:epidemiology; D007262:Infusions, Intravenous; D007430:Intraoperative Care / Q000379:methods; D007902:Length of Stay; D008012:Lidocaine / Q000008:administration & dosage / Q000627:therapeutic use*; D008297:Male; D008614:Meperidine / Q000008:administration & dosage / Q000627:therapeutic use; D008875:Middle Aged; D010147:Pain Measurement; D010149:Postoperative Pain / Q000188:drug therapy / Q000517:prevention & control; D011446:Prospective Studies; D013274:Stomach Neoplasms / Q000601:surgery*; D013997:Time Factors
chemical_list: D000701:Analgesics, Opioid; D000779:Anesthetics, Local; D008012:Lidocaine; D008614:Meperidine