title: Metal-free reactions of alkynes via electrophilic iodocarbocyclizations.
abstract: Despite attracting tremendous interest over the last few decades, the field of electrophilic cyclizations is still continuously and rapidly developing. Particularly, metal-free reactions that involve the activation of an alkyne using electrophilic halogen sources are powerful tools in the repertoire of synthetic chemists. This brief overview highlights recent progress in C-C bond-forming halocyclizations allowing for the reaction of alkynes with carbon-nucleophiles. Primarily guided by the type of carbon nucleophile, methods are categorized as the addition of arene, malonate, and olefin nucleophiles.
authors.affiliation: Organic Chemistry, Bergische Universität Wuppertal, Gaußstr. 20, 42119 Wuppertal, Germany.
authors.forename: Adeline
authors.initials: A
authors.lastname: Palisse
authors.forename: Stefan F
authors.initials: SF
authors.lastname: Kirsch
mesh_terms: D000480:Alkynes / Q000737:chemistry*; D003500:Cyclization; D006219:Halogens / Q000737:chemistry*; D006846:Hydrocarbons, Halogenated / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure
chemical_list: D000480:Alkynes; D006219:Halogens; D006846:Hydrocarbons, Halogenated