title: Bioinspired bioadhesive polymers: dopa-modified poly(acrylic acid) derivatives.
abstract: The one-step synthesis and characterization of novel bioinspired bioadhesive polymers that contain Dopa, implicated in the extremely adhesive byssal fibers of certain gastropods, is reported. The novel polymers consist of combinations of either of two polyanhydride backbones and one of three amino acids, phenylalanine, tyrosine, or Dopa, grafted as side chains. Dopa-grafted hydrophobic backbone polymers exhibit as much as 2.5 × the fracture strength and 2.8 × the tensile work of bioadhesion of a commercially available poly(acrylic acid) derivative as tested on live, excised, rat intestinal tissue.
authors.affiliation: Department of Molecular Pharmacology, Physiology, and Biotechnology, Brown University, Providence, RI 02912, USA.
authors.forename: Bryan
authors.initials: B
authors.lastname: Laulicht
authors.forename: Alexis
authors.initials: A
authors.lastname: Mancini
authors.forename: Nathanael
authors.initials: N
authors.lastname: Geman
authors.forename: Daniel
authors.initials: D
authors.lastname: Cho
authors.forename: Kenneth
authors.initials: K
authors.lastname: Estrellas
authors.forename: Stacia
authors.initials: S
authors.lastname: Furtado
authors.forename: Russell
authors.initials: R
authors.lastname: Hopson
authors.forename: Anubhav
authors.initials: A
authors.lastname: Tripathi
authors.forename: Edith
authors.initials: E
authors.lastname: Mathiowitz
mesh_terms: D000180:Acrylic Resins / Q000737:chemistry* / Q000494:pharmacology; D000268:Adhesiveness; D000818:Animals; D040761:Biomimetic Materials / Q000138:chemical synthesis* / Q000494:pharmacology; D002152:Calorimetry, Differential Scanning; D004295:Dihydroxyphenylalanine / Q000737:chemistry*; D049851:Gastropoda / Q000737:chemistry; D007422:Intestines / Q000187:drug effects; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D008422:Materials Testing; D008768:Methylmethacrylates / Q000737:chemistry* / Q000494:pharmacology; D010649:Phenylalanine / Q000737:chemistry; D051381:Rats; D017207:Rats, Sprague-Dawley; D017550:Spectroscopy, Fourier Transform Infrared; D013718:Tensile Strength; D014014:Tissue Adhesives / Q000138:chemical synthesis* / Q000494:pharmacology; D046509:Tissue Culture Techniques; D014443:Tyrosine / Q000737:chemistry
chemical_list: D000180:Acrylic Resins; D008768:Methylmethacrylates; D014014:Tissue Adhesives; D014443:Tyrosine; D010649:Phenylalanine; C006903:carbopol 940; D004295:Dihydroxyphenylalanine; C009931:poly(ethylmethacrylate)