title: Post-embolisation susceptibility changes in giant meningiomas: multiparametric histogram analysis using non-contrast-enhanced susceptibility-weighted PRESTO, diffusion-weighted and perfusion-weighted imaging.
abstract: OBJECTIVE
  To investigate imaging characteristics of post-embolised meningioma and to determine if SW imaging can delineate tumour ischaemia.
  
  
  METHODS
  Sixteen patients were studied before and after preoperative embolisation therapy (8 histopathologically determined with ischaemia, 8 with non-ischaemia). In each patient, a slice-wise ROI for the entire tumour was established, and histogram variables (mean, SD, minimum, maximum, histogram width, mode, and peak height) of SW, ADC, CBV, CBF, MTT, and TTP maps were compared between ischaemic and non-ischaemic groups. Changes in SW histogram were correlated with histopathological characteristics.
  
  
  RESULTS
  Signal intensity on the SW map tended to decrease in the ischaemic group and partially increased in the non-ischaemic group. A similar trend was observed on the ADC map. The PW histogram showed an MTT increase in ischaemic group; however, CBV did not show significant changes between ischaemic and non-ischaemic groups. Microhaemorrhage was slightly correlated with Δpeak height in the SW histogram.
  
  
  CONCLUSIONS
  Post-embolisation changes of intrinsic T2-weighted MR contrasts on SW map are most likely associated with alterations in deoxyhaemoglobin levels and arterial blood flow.
authors.affiliation: Department of Radiology, Osaka City University Graduate School of Medicine, 1-4-3 Asahimachi, Abeno, Osaka 545-8585, Japan. tomokazu-n@med.osaka-cu.ac.jp
authors.forename: Tomokazu
authors.initials: T
authors.lastname: Nishiguchi
authors.forename: Takeshi
authors.initials: T
authors.lastname: Iwakiri
authors.forename: Kohji
authors.initials: K
authors.lastname: Hayasaki
authors.forename: Masahiko
authors.initials: M
authors.lastname: Ohsawa
authors.forename: Tetuya
authors.initials: T
authors.lastname: Yoneda
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Mitsuhashi
authors.forename: Akimasa
authors.initials: A
authors.lastname: Nishio
authors.forename: Vincent
authors.initials: V
authors.lastname: Dousset
authors.forename: Yukio
authors.initials: Y
authors.lastname: Miki
mesh_terms: D000328:Adult; D000368:Aged; D001707:Biopsy, Needle; D001931:Brain Mapping / Q000379:methods; D003131:Combined Modality Therapy; D003287:Contrast Media; D038524:Diffusion Magnetic Resonance Imaging / Q000379:methods*; D004621:Embolization, Therapeutic / Q000009:adverse effects / Q000379:methods*; D005069:Evaluation Studies as Topic; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007090:Image Interpretation, Computer-Assisted; D007150:Immunohistochemistry; D008297:Male; D008577:Meningeal Neoplasms / Q000175:diagnosis / Q000473:pathology* / Q000628:therapy*; D008579:Meningioma / Q000175:diagnosis / Q000473:pathology* / Q000628:therapy*; D008875:Middle Aged; D009367:Neoplasm Staging; D019635:Neurosurgical Procedures / Q000379:methods; D016011:Normal Distribution; D011300:Preoperative Care / Q000379:methods; D012307:Risk Factors; D012494:Sampling Studies; D016896:Treatment Outcome
chemical_list: D003287:Contrast Media