title: E-Selectin S128R gene polymorphism in gastric cancer.
abstract: BACKGROUND
  E-selectin is an adhesion molecule expressed on activated endothelial cells. E-selectin plays an important role in the process of inflammation and is also involved in the mechanism of cancer metastasis regulating the adhesion of circulating cancer cells to the blood vessels. The aim of our study was to determine whether an association exists between its most common gene polymorphism, S128R, and gastric cancer (GC).
  
  
  METHODS
  We performed a case-control study of 88 GC cases and 480 controls to analyze the association between E-selectin S128R gene polymorphism and GC susceptibility. The genotyping analysis was done by PCR-restriction fragment length polymorphism method.
  
  
  RESULTS
  The E-selectin S128R C allele, CA and CC genotypes were over-represented among the GC cases. No statistically significant association was observed between E-selectin S128R polymorphisms and tumor characteristics. However, carrying the C allele was associated with poor survival.
  
  
  CONCLUSIONS
  The E-selectin S128R C allele may confer an increased susceptibility to gastric cancer development and correlate with a poor prognosis.
authors.affiliation: First Surgical Department Tzaneion Hospital, Piraeus, Greece.
authors.forename: Emmanouil
authors.initials: E
authors.lastname: Liarmakopoulos
authors.forename: Maria
authors.initials: M
authors.lastname: Gazouli
authors.forename: Gerasimos
authors.initials: G
authors.lastname: Aravantinos
authors.forename: George
authors.initials: G
authors.lastname: Theodoropoulos
authors.forename: Spyros
authors.initials: S
authors.lastname: Rizos
authors.forename: Anna
authors.initials: A
authors.lastname: Vaiopoulou
authors.forename: Gregory
authors.initials: G
authors.lastname: Kouraklis
authors.forename: Nikolaos
authors.initials: N
authors.lastname: Nikiteas
mesh_terms: D000368:Aged; D019943:Amino Acid Substitution; D016022:Case-Control Studies; D019040:E-Selectin / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006801:Humans; D053208:Kaplan-Meier Estimate; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D013274:Stomach Neoplasms / Q000235:genetics* / Q000401:mortality
chemical_list: D019040:E-Selectin; C546936:SELE protein, human