title: In vitro Etest synergy of doripenem with amikacin, colistin, and levofloxacin against Pseudomonas aeruginosa with defined carbapenem resistance mechanisms as determined by the Etest method.
abstract: The applicability of Etest for synergy testing was evaluated in 100 carbapenem-nonsusceptible Pseudomonas aeruginosa isolates. Combinations of doripenem with amikacin, colistin, or levofloxacin were synergistic or additive against 67%, 31%, and 23% of isolates, respectively. The use of Etest was practical to evaluate the synergy of doripenem with other antipseudomonal agents.
authors.affiliation: Janssen Pharmaceutical Research and Development, Raritan, NJ 08869, USA. WHe8@its.jnj.com
authors.forename: Wendy
authors.initials: W
authors.lastname: He
authors.forename: Koné
authors.initials: K
authors.lastname: Kaniga
authors.forename: A Simon
authors.initials: AS
authors.lastname: Lynch
authors.forename: Robert K
authors.initials: RK
authors.lastname: Flamm
authors.forename: Todd A
authors.initials: TA
authors.lastname: Davies
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D003091:Colistin / Q000494:pharmacology*; D004357:Drug Synergism; D006801:Humans; D008826:Microbial Sensitivity Tests / Q000379:methods; D011552:Pseudomonas Infections / Q000382:microbiology; D011550:Pseudomonas aeruginosa / Q000187:drug effects* / Q000302:isolation & purification; D018440:beta-Lactam Resistance; D047090:beta-Lactams / Q000494:pharmacology*
chemical_list: D000900:Anti-Bacterial Agents; D047090:beta-Lactams; D003091:Colistin