title: "Organo-metal" synergistic catalysis: the 1+1>2 effect for the construction of spirocyclopentene oxindoles.
abstract: Synergy in action: a highly efficient "organo-metal" synergistic catalysis strategy for the synthesis of spirocyclopentene oxindole derivatives has been developed. The lower overall d.r. and ee obtained from the stepwise approach (4:1 vs. 8:1 d.r.; 71 vs. >99 % ee) suggest that both catalysts function more efficiently when combined, compared with the separate catalytic approach, and show an evident 1+1>2 synergistic effect for the construction of spirocyclopentene oxindoles.
authors.affiliation: Key Laboratory of Preclinical Study for New Drugs of Gansu Province, School of Life Sciences, Lanzhou University, PR China.
authors.forename: Wangsheng
authors.initials: W
authors.lastname: Sun
authors.forename: Gongming
authors.initials: G
authors.lastname: Zhu
authors.forename: Chongyang
authors.initials: C
authors.lastname: Wu
authors.forename: Liang
authors.initials: L
authors.lastname: Hong
authors.forename: Rui
authors.initials: R
authors.lastname: Wang
mesh_terms: D000447:Aldehydes / Q000737:chemistry; D002384:Catalysis; D018360:Crystallography, X-Ray; D007211:Indoles / Q000737:chemistry*; D008670:Metals / Q000737:chemistry*; D008968:Molecular Conformation; D000078183:Oxindoles; D013141:Spiro Compounds / Q000138:chemical synthesis / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D000447:Aldehydes; D007211:Indoles; D008670:Metals; D000078183:Oxindoles; D013141:Spiro Compounds; C022960:2-oxindole