title: HLA class I allele frequencies in the Lebanese population.
abstract: The highly polymorphic Human Leukocyte Antigen system encompasses different loci that have been studied in transplantation as well as diseases and population associated research. This study is the first and largest of its kind to describe the distribution of HLA-A, -B and -C alleles in Lebanon. Respectively, 1994, 1309 and 1163 Lebanese individuals referred for HLA typing and possible bone marrow/kidney donation were tested for HLA-A, HLA-B and HLA-C alleles using the polymerase chain reaction/Sequence specific priming (PCR-SSP) method. Our data were compared to that of several populations with interesting and common findings shared with the Moroccan, Jordanian, Tunisian, Omani, Korean, Chinese, Japanese, Peruan, Bulgarian, Irish, Polish, Spanish, Swiss, American, African and Brazilian populations. The following data concerning the Lebanese population will help future investigators to study the relation of HLA-A, -B and -C alleles with common diseases in Lebanon and will add to the available international literature. This new data will serve as a major reference report in the region.
authors.affiliation: Department of Pathology & Laboratory Medicine, American University of Beirut Medical Center, Beirut, Lebanon.
authors.forename: Sara
authors.initials: S
authors.lastname: Khansa
authors.forename: Rouba
authors.initials: R
authors.lastname: Hoteit
authors.forename: Dina
authors.initials: D
authors.lastname: Shammaa
authors.forename: Rabab Abdel
authors.initials: RA
authors.lastname: Khalek
authors.forename: Hussein
authors.initials: H
authors.lastname: El Halas
authors.forename: Layal
authors.initials: L
authors.lastname: Greige
authors.forename: Fatmeh
authors.initials: F
authors.lastname: Abbas
authors.forename: Rami A R
authors.initials: RA
authors.lastname: Mahfouz
mesh_terms: D000483:Alleles; D005260:Female; D005787:Gene Frequency; D005828:Genetics, Population; D015395:Histocompatibility Antigens Class I / Q000235:genetics*; D006650:Histocompatibility Testing; D006801:Humans; D007861:Lebanon; D008297:Male
chemical_list: D015395:Histocompatibility Antigens Class I