title: Inter- and intrahemispheric dissociations in ideomotor apraxia: a large-scale lesion-symptom mapping study in subacute brain-damaged patients.
abstract: Pantomimes of object use require accurate representations of movements and a selection of the most task-relevant gestures. Prominent models of praxis, corroborated by functional neuroimaging studies, predict a critical role for left parietal cortices in pantomime and advance that these areas store representations of tool use. In contrast, lesion data points to the involvement of left inferior frontal areas, suggesting that defective selection of movement features is the cause of pantomime errors. We conducted a large-scale voxel-based lesion-symptom mapping analyses with configural/spatial (CS) and body-part-as-object (BPO) pantomime errors of 150 left and right brain-damaged patients. Our results confirm the left hemisphere dominance in pantomime. Both types of error were associated with damage to left inferior frontal regions in tumor and stroke patients. While CS pantomime errors were associated with left temporoparietal lesions in both stroke and tumor patients, these errors appeared less associated with parietal areas in stroke than in tumor patients and less associated with temporal in tumor than stroke patients. BPO errors were associated with left inferior frontal lesions in both tumor and stroke patients. Collectively, our results reveal a left intrahemispheric dissociation for various aspects of pantomime, but with an unspecific role for inferior frontal regions.
authors.affiliation: Department of Clinical Neurosciences, Neuropsychology and Neurorehabilitation Service, Vaudois University Hospital Center and University of Lausanne, 1011 Lausanne, Switzerland and.
authors.forename: Aurelie L
authors.initials: AL
authors.lastname: Manuel
authors.forename: Narges
authors.initials: N
authors.lastname: Radman
authors.forename: Delphine
authors.initials: D
authors.lastname: Mesot
authors.forename: Leila
authors.initials: L
authors.lastname: Chouiter
authors.forename: Stephanie
authors.initials: S
authors.lastname: Clarke
authors.forename: Jean-Marie
authors.initials: JM
authors.lastname: Annoni
authors.forename: Lucas
authors.initials: L
authors.lastname: Spierer
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D020240:Apraxia, Ideomotor / Q000473:pathology / Q000503:physiopathology*; D001925:Brain Damage, Chronic / Q000473:pathology / Q000503:physiopathology; D001931:Brain Mapping; D002540:Cerebral Cortex / Q000473:pathology* / Q000503:physiopathology*; D005260:Female; D005625:Frontal Lobe / Q000473:pathology / Q000503:physiopathology; D007839:Functional Laterality; D006801:Humans; D007100:Imitative Behavior; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D010296:Parietal Lobe / Q000473:pathology / Q000503:physiopathology; D055815:Young Adult