title: SNARing platelet granule secretion.
abstract: In this issue of Blood, Ye et al and Al Hawas et al clarify the roles of 2 key fusion proteins that regulate the agonist-stimulated release of bioactive factors from platelets, and thereby explain the defective hemostasis in patients with 2 rare genetic diseases.
authors.affiliation: University of Pennsylvania.
authors.forename: Michael S
authors.initials: MS
authors.lastname: Marks
mesh_terms: D000818:Animals; D001792:Blood Platelets / Q000378:metabolism*; D005089:Exocytosis / Q000502:physiology*; D005260:Female; D006801:Humans; D051359:Lymphohistiocytosis, Hemophagocytic / Q000378:metabolism*; D008297:Male; D051938:Munc18 Proteins / Q000378:metabolism*; D050765:Qa-SNARE Proteins / Q000378:metabolism / Q000502:physiology*; D050600:SNARE Proteins / Q000378:metabolism*; D050827:Syntaxin 1 / Q000502:physiology*
chemical_list: D051938:Munc18 Proteins; D050765:Qa-SNARE Proteins; D050600:SNARE Proteins; C541732:STX11 protein, human; D050827:Syntaxin 1