title: Preclinical combination therapy of clofarabine plus radiation.
abstract: Clofarabine, an approved anticancer drug, was evaluated in combination with radiation in six subcutaneously implanted human tumor xenograft models. Clofarabine had no effect on the growth of SF-295 glioblastoma, which was not enhanced by radiation. There was no difference between clofarabine with and without radiation in the DU-145 prostate model. The combined effect on NCI-H460 lung tumors appeared to be additive. SR475 head and neck, PANC-1 pancreatic, and HCT-116 colon tumors were radiomodified by clofarabine. The radiomodifying capacity of clofarabine was superior to that for gemcitabine in two models (PANC-1 and HCT-116) and was comparable in the other four models.
authors.affiliation: Department of Cancer Therapeutics and Immunology, Southern Research Institute, Birmingham, Alabama, USA.
authors.forename: Murray A
authors.initials: MA
authors.lastname: Stackhouse
authors.forename: Karen S
authors.initials: KS
authors.lastname: Gilbert
authors.forename: Jeffery W
authors.initials: JW
authors.lastname: Scoggins
authors.forename: William R
authors.initials: WR
authors.lastname: Waud
mesh_terms: D000227:Adenine Nucleotides / Q000008:administration & dosage / Q000627:therapeutic use*; D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D001087:Arabinonucleosides / Q000008:administration & dosage / Q000627:therapeutic use*; D045744:Cell Line, Tumor; D000077866:Clofarabine; D003131:Combined Modality Therapy; D003841:Deoxycytidine / Q000008:administration & dosage / Q000031:analogs & derivatives / Q000627:therapeutic use; D004353:Drug Evaluation, Preclinical; D006801:Humans; D051379:Mice; D008819:Mice, Nude; D009374:Neoplasms, Experimental / Q000188:drug therapy / Q000532:radiotherapy / Q000628:therapy*; D047368:Tumor Burden / Q000187:drug effects; D023041:Xenograft Model Antitumor Assays; D000093542:Gemcitabine
chemical_list: D000227:Adenine Nucleotides; D000970:Antineoplastic Agents; D001087:Arabinonucleosides; D003841:Deoxycytidine; D000077866:Clofarabine; D000093542:Gemcitabine