title: Neurofibromatosis type 1 (NF1) associated with tumor of the corpus callosum.
abstract: BACKGROUND
  Neurofibromatosis type 1 (NF1), one of the most common neurocutaneous disorders, is a multisystemic disease associated with tumors in any organ of the body, especially in the central nervous system and also the peripheral nervous system. Pilocytic astrocytomas have been described in almost all intracranial regions in patients with NF1. However, only a few patients with NF1 and tumor of the corpus callosum have been reported to date.
  
  
  METHODS
  An 11-year-old white Spanish boy was evaluated due to a family history of NF1 and low performance test scores in school. He was studied from the neurological and intellectual level points of view.
  
  
  RESULTS
  Magnetic resonance (MR) study revealed a tumor in the anterior-middle portion of the corpus callosum and a Wechsler Intelligence Scale for Children-Revised showed verbal IQ of 92, a performance IQ of 108, and a total IQ of 100. In addition, he showed attention deficit and hyperactivity disorder.
  
  
  CONCLUSIONS
  Tumors of corpus callosum in patients with NF1 are very uncommon. The patient presented in this paper consulted due to family history of NF1, progressive hyperactivity, and below average school performance. The MR study showed tumor in the corpus callosum. Tumor histology was not investigated.
authors.affiliation: Pediatric Neurology Service, University Hospital La Paz, Paseo de Castellana 261, 28046 Madrid, Spain. i.pcastroviejo@neurologia.e.telefonica.net
authors.forename: Ignacio
authors.initials: I
authors.lastname: Pascual-Castroviejo
authors.forename: Samuel-Ignacio
authors.initials: SI
authors.lastname: Pascual-Pascual
mesh_terms: D001254:Astrocytoma / Q000150:complications* / Q000473:pathology* / Q000523:psychology; D001289:Attention Deficit Disorder with Hyperactivity / Q000150:complications / Q000523:psychology; D001932:Brain Neoplasms / Q000150:complications* / Q000473:pathology* / Q000523:psychology; D002648:Child; D003337:Corpus Callosum / Q000473:pathology*; D006801:Humans; D007361:Intelligence Tests; D008279:Magnetic Resonance Imaging; D008297:Male; D009456:Neurofibromatosis 1 / Q000150:complications* / Q000473:pathology* / Q000523:psychology; D009483:Neuropsychological Tests; D010641:Phenotype; D014888:Wechsler Scales