title: Inter-observer agreement for spectral- and time-domain optical coherence tomography image grading: a prospective study.
abstract: The purpose of this study was to compare inter-observer agreement of Stratus™ OCT versus Spectralis™ OCT image grading in patients with neovascular age-related macular degeneration (AMD). Thirty eyes with neovascular AMD were examined with Stratus™ OCT and Spectralis™ OCT. Four different scan protocols were used for imaging. Three observers graded the images for the presence of various pathologies. Inter-observer agreement between OCT models was assessed by calculating intra-class correlation coefficients (ICC). In Stratus™ OCT highest interobserver agreement was found for subretinal fluid (ICC: 0.79), and in Spectralis™ OCT for intraretinal cysts (IRC) (ICC: 0.93). Spectralis™ OCT showed superior interobserver agreement for IRC and epiretinal membranes (ERM) (ICC(Stratus™): for IRC 0.61; for ERM 0.56; ICC(Spectralis™): for IRC 0.93; for ERM 0.84). Increased image resolution of Spectralis™ OCT did improve the inter-observer agreement for grading intraretinal cysts and epiretinal membranes but not for other retinal changes.
authors.affiliation: Department of Ophthalmology, University Hospital Zurich, Zurich, Switzerland.
authors.forename: Pascal B
authors.initials: PB
authors.lastname: Knecht
authors.forename: Helena
authors.initials: H
authors.lastname: Kordic
authors.forename: Malaika
authors.initials: M
authors.lastname: Kurz-Levin
authors.forename: Veit
authors.initials: V
authors.lastname: Sturm
authors.forename: Marcel N
authors.initials: MN
authors.lastname: Menke
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006801:Humans; D008268:Macular Degeneration / Q000150:complications / Q000175:diagnosis*; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D012372:ROC Curve; D015203:Reproducibility of Results; D012160:Retina / Q000473:pathology*; D015861:Retinal Neovascularization / Q000150:complications / Q000175:diagnosis*; D058471:Subretinal Fluid; D041623:Tomography, Optical Coherence / Q000379:methods*