title: Bioactive glass S53P4 in mastoid obliteration surgery for chronic otitis media and cerebrospinal fluid leakage.
abstract: OBJECTIVE
  We evaluated the results of cases of chronic otitis media treated with mastoid obliteration surgery using bioactive glass S53P4.
  
  
  METHODS
  Twenty-five patients with chronic otitis media and 1 patient with cerebrospinal fluid leakage without chronic infection were treated with bioactive glass S53P4. Twenty patients had had previous surgery because of chronic otitis media with or without cholesteatoma. A mastoid obliteration was performed with bioactive glass S53P4 granules and a musculoperiosteal flap with or without bone paté. In 2 patients with a bony dehiscence at the middle cranial fossa, a bioactive glass plate was used to support the protruding dura. In addition, in 3 patients, occlusion of a dural fistula was needed The median follow-up period was 34.5 months (range, 1 to 182 months).
  
  
  RESULTS
  Excluding the 2 patients with only 1 month of follow-up at our department, 96% of the patients had a dry, safe ear or only intermittent otorrhea. In 92% of the patients, the objective of achieving a smaller or nonexistent cavity was achieved.
  
  
  CONCLUSIONS
  Bioactive glass S53P4 is a noteworthy material in mastoid obliteration surgery.
authors.affiliation: Department of Otorhinolaryngology-Head and Neck Surgery, Turku University Hospital and University of Turku, Turku, Finland.
authors.forename: Jussi
authors.initials: J
authors.lastname: Sarin
authors.forename: Reidar
authors.initials: R
authors.lastname: Grénman
authors.forename: Kalle
authors.initials: K
authors.lastname: Aitasalo
authors.forename: Jaakko
authors.initials: J
authors.lastname: Pulkkinen
mesh_terms: D000328:Adult; D000368:Aged; D018786:Bone Substitutes; D065634:Cerebrospinal Fluid Leak; D002559:Cerebrospinal Fluid Rhinorrhea / Q000601:surgery*; D018424:Cholesteatoma, Middle Ear / Q000601:surgery; D002908:Chronic Disease; D005260:Female; D005898:Glass; D006801:Humans; D008297:Male; D008416:Mastoid / Q000601:surgery*; D008875:Middle Aged; D010033:Otitis Media / Q000601:surgery*; D013506:Otologic Surgical Procedures / Q000009:adverse effects / Q000379:methods
chemical_list: D018786:Bone Substitutes; C403922:bioactive glass S53P4