title: Correlation of bone alkaline phosphatase and iPTH with some basic biochemical markers in predialysis and dialysis patients.
abstract: BACKGROUND
  Bone alkaline phosphatase (BALP) is a direct and independent indicator of impaired bone turnover. We intended to find out whether there are any significant changes in BALP and iPTH levels, in comparison to total Ca, total Mg, inorganic P, total alkaline phosphatase (ALP), and tartrate resistant acid phosphatase (TRAP) in predialysis and dialysis patients.
  
  
  METHODS
  Out of 266 patients investigated, 114 were on continuous ambulatory peritoneal dialysis, 112 were on maintenance haemodialysis, while 40 predialysis patients had end stage renal disease. The parameters were analysed according to the manufacturers' instructions.
  
  
  RESULTS
  Correlations were established for the bone marker concentrations analysed among the studied groups. The largest ranges were determined for BALP and iPTH. Predialysis and dialysis patients showed very low levels of BALP. Dialysis patients had lower levels of iPTH (p < 0.001), while in predialysis patients the levels were significantly higher (p < 0.05) than recommended for low bone turnover, according to K/DOQI.
  
  
  CONCLUSIONS
  The observations made in this study identify BALP as a good indicator of decreased bone turnover in predialysis and dialysis patients. However, in order to reveal a difference between bone activity and the level of parathyroid activity and its effect on bone turnover, it is always necessary to observe both BALP and iPTH levels.
authors.affiliation: Center of Medical Biochemistry, Clinical Center of Serbia, Institute of Medical Biochemistry, Pharmaceutical Faculty, University of Belgrade, Serbia. nedanvkvc@yahoo.com
authors.forename: Neda L
authors.initials: NL
authors.lastname: Milinković
authors.forename: Nada T
authors.initials: NT
authors.lastname: Majkic-Singh
authors.forename: Svetlana D
authors.initials: SD
authors.lastname: Ignjatović
authors.forename: Visnja D
authors.initials: VD
authors.lastname: Lezaić
authors.forename: Svetlana D
authors.initials: SD
authors.lastname: Pejanović
authors.forename: Dijana B
authors.initials: DB
authors.lastname: Jovanovic
mesh_terms: D000469:Alkaline Phosphatase / Q000378:metabolism*; D001842:Bone and Bones / Q000201:enzymology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010281:Parathyroid Hormone / Q000032:analysis*; D006435:Renal Dialysis
chemical_list: D010281:Parathyroid Hormone; D000469:Alkaline Phosphatase