title: Scope of the two-step, one-pot palladium-catalyzed borylation/Suzuki cross-coupling reaction utilizing bis-boronic acid.
abstract: The use of bis-boronic acid for the direct synthesis of boronic acids has greatly facilitated the two-step, one-pot borylation/Suzuki cross-coupling reaction between aryl and heteroaryl halides. With use of Buchwald's second-generation XPhos preformed catalyst, high yields of cross-coupled products were obtained for most substrates. The method also allows an efficient two-step, one-pot synthesis, providing access to three distinct cross-coupled products after column chromatography. The method also provides a rapid and convenient route to teraryl compounds.
authors.affiliation: Roy and Diana Vagelos Laboratories, Department of Chemistry, University of Pennsylvania, Philadelphia, Pennsylvania 19104-6323, United States. gmolandr@sas.upenn.edu
authors.forename: Gary A
authors.initials: GA
authors.lastname: Molander
authors.forename: Sarah L J
authors.initials: SL
authors.lastname: Trice
authors.forename: Steven M
authors.initials: SM
authors.lastname: Kennedy
mesh_terms: D001897:Boronic Acids / Q000737:chemistry*; D002384:Catalysis; D002853:Chromatography, Liquid / Q000379:methods; D003432:Cross-Linking Reagents / Q000138:chemical synthesis* / Q000737:chemistry*; D006846:Hydrocarbons, Halogenated / Q000737:chemistry*; D015394:Molecular Structure; D010165:Palladium / Q000737:chemistry*
chemical_list: D001897:Boronic Acids; D003432:Cross-Linking Reagents; D006846:Hydrocarbons, Halogenated; D010165:Palladium