title: [Value of combined detection of GP73 and alpha-fetoprotein in diagonosis of hepatocellular carcinoma].
abstract: OBJECTIVE
  To explore the diagnostic value of the measurement of serum Golgi protein 73 (GP73) in the diagnosis of hepatocellular carcinoma (HCC).
  
  
  METHODS
  Enzyme-linked immunosorbent assay (ELISA) was used to detect the serum GP73 in the 81 cases of HCC, 71 cases of chronic hepatitis or cirrhosis (CH/LC) and 65 cases of healthy blood donors, and to evaluate the sensitivity and specificity in the diagnosis of HCC through the ROC curves.
  
  
  RESULTS
  The average levels of serum GP73 in HCC, CH/LC and Normal groups were (152.67 +/- 33.59) ng/ml, (93.15 +/- 20.02) ng/ml and (58.95 +/- 17.29) ng/ml(o) After calculating through the ROC curves, 120 ng/ml was set as the optimal cut-off point, GP73 has a sensitivity of 77.80% and a specificity of 78.00%.
  
  
  CONCLUSIONS
  GP73 as a serum marker in the diagnosis of HCC had a higher sensitivity than AFP, and the combined detection of GP73 and AFP could improve HCC diagnosis.
authors.affiliation: Ningbo Medical Center Lihuili Hospital, Ninbo 315040, China.
authors.forename: Qiao-Ping
authors.initials: QP
authors.lastname: Wu
authors.forename: Fu-Yi
authors.initials: FY
authors.lastname: Xie
authors.forename: Qing-Ling
authors.initials: QL
authors.lastname: Meng
authors.forename: Yin-Yu
authors.initials: YY
authors.lastname: Mu
mesh_terms: D006528:Carcinoma, Hepatocellular / Q000175:diagnosis*; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D008103:Liver Cirrhosis / Q000097:blood; D008113:Liver Neoplasms / Q000175:diagnosis*; D008297:Male; D008565:Membrane Proteins / Q000097:blood*; D000509:alpha-Fetoproteins / Q000032:analysis*
chemical_list: C410824:GOLM1 protein, human; D008565:Membrane Proteins; D000509:alpha-Fetoproteins