title: Familial Mediterranean fever with onset at 66 years of age.
abstract: The patient was a 68-year-old woman who had experienced recurrent febrile episodes since 66 years of age. Despite various examinations and treatments, the etiology remained unclear. Further examinations following another referral failed to uncover the cause. Therefore, despite her age, it was presumed that she had familial Mediterranean fever. An analysis of the familial Mediterranean fever (MEFV) gene detected heterozygous L110P, E148Q, and R202Q mutations. No further febrile episodes occurred after colchicine treatment was initiated. Familial Mediterranean fever presenting in patients in their sixties is extremely rare.
authors.affiliation: Department of General Medicine, Nagasaki University School of Medicine, Japan. inoway77@gmail.com
authors.forename: Keita
authors.initials: K
authors.lastname: Inoue
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Torii
authors.forename: Aya
authors.initials: A
authors.lastname: Yoda
authors.forename: Koichiro
authors.initials: K
authors.lastname: Kadota
authors.forename: Seiko
authors.initials: S
authors.lastname: Nakamichi
authors.forename: Yoko
authors.initials: Y
authors.lastname: Obata
authors.forename: Tomoya
authors.initials: T
authors.lastname: Nishino
authors.forename: Kiyoshi
authors.initials: K
authors.lastname: Migita
authors.forename: Atsushi
authors.initials: A
authors.lastname: Kawakami
authors.forename: Yoshiyuki
authors.initials: Y
authors.lastname: Ozono
mesh_terms: D017668:Age of Onset; D000368:Aged; D003078:Colchicine / Q000627:therapeutic use; D003598:Cytoskeletal Proteins / Q000235:genetics; D010505:Familial Mediterranean Fever / Q000175:diagnosis* / Q000188:drug therapy / Q000453:epidemiology*; D005260:Female; D006579:Heterozygote; D006801:Humans; D009154:Mutation / Q000235:genetics; D000071198:Pyrin; D016896:Treatment Outcome
chemical_list: D003598:Cytoskeletal Proteins; C000604192:MEFV protein, human; D000071198:Pyrin; D003078:Colchicine