title: Modeling ion channel dynamics through reflected stochastic differential equations.
abstract: Ion channels are membrane proteins that open and close at random and play a vital role in the electrical dynamics of excitable cells. The stochastic nature of the conformational changes these proteins undergo can be significant, however current stochastic modeling methodologies limit the ability to study such systems. Discrete-state Markov chain models are seen as the "gold standard," but are computationally intensive, restricting investigation of stochastic effects to the single-cell level. Continuous stochastic methods that use stochastic differential equations (SDEs) to model the system are more efficient but can lead to simulations that have no biological meaning. In this paper we show that modeling the behavior of ion channel dynamics by a reflected SDE ensures biologically realistic simulations, and we argue that this model follows from the continuous approximation of the discrete-state Markov chain model. Open channel and action potential statistics from simulations of ion channel dynamics using the reflected SDE are compared with those of a discrete-state Markov chain method. Results show that the reflected SDE simulations are in good agreement with the discrete-state approach. The reflected SDE model therefore provides a computationally efficient method to simulate ion channel dynamics while preserving the distributional properties of the discrete-state Markov chain model and also ensuring biologically realistic solutions. This framework could easily be extended to other biochemical reaction networks.
authors.affiliation: Department of Computer Science, University of Oxford, Wolfson Building, Parks Road, Oxford OX1 3QD, United Kingdom. ciara.dangerfield@dtc.ox.ac.uk
authors.forename: Ciara E
authors.initials: CE
authors.lastname: Dangerfield
authors.forename: David
authors.initials: D
authors.lastname: Kay
authors.forename: Kevin
authors.initials: K
authors.lastname: Burrage
mesh_terms: D000200:Action Potentials; D004058:Diffusion; D015640:Ion Channel Gating; D007473:Ion Channels / Q000378:metabolism*; D008390:Markov Chains; D008954:Models, Biological; D013269:Stochastic Processes
chemical_list: D007473:Ion Channels