title: Postprandial dysmetabolism and the heart.
abstract: Epidemiologic evidence indicates that abnormal elevations in glycemia and lipidemia after a meal, termed postprandial dysmetabolism, are linked with increased risk of morbidity and mortality due to cardiovascular disease in individuals with or without type 2 diabetes. Both postprandial hyperglycemia and postprandial hyperlipidemia are independently associated with deteriorating endothelial function and vascular damage, which are likely mediated by increased oxidative stress and are more pronounced when both derangements coexist. Pharmacotherapies that target postprandial hyperglycemia and/or postprandial dyslipidemia are likely to improve endothelial function, which may have positive implications for cardiovascular outcomes.
authors.affiliation: Division of Diabetes, Endocrinology and Metabolism, Department of Medicine, Baylor College of Medicine, 1709 Dryden Road, Houston, TX 77030, USA. agarber@bcm.tmc.edu
authors.forename: Alan J
authors.initials: AJ
authors.lastname: Garber
mesh_terms: D002318:Cardiovascular Diseases / Q000209:etiology* / Q000473:pathology; D004730:Endothelium, Vascular / Q000473:pathology; D006321:Heart / Q000503:physiopathology*; D006801:Humans; D006943:Hyperglycemia / Q000150:complications* / Q000188:drug therapy / Q000473:pathology; D006949:Hyperlipidemias / Q000150:complications* / Q000188:drug therapy / Q000473:pathology; D007004:Hypoglycemic Agents / Q000627:therapeutic use; D000960:Hypolipidemic Agents / Q000627:therapeutic use; D012307:Risk Factors
chemical_list: D007004:Hypoglycemic Agents; D000960:Hypolipidemic Agents