title: Relationship between the prohibitin 3' untranslated region C > T gene polymorphism and cancer susceptibility--results of a meta-analysis.
abstract: OBJECTIVE
  The results from the published studies on the association between prohibitin 3' untranslated region C > T gene polymorphism and cancer risk are conflicting. This meta-analysis was performed to evaluate the relationship with cancer susceptibility overall, and to explore whether the T allele or TT genotype could become a predictive marker for cancer risk.
  
  
  METHODS
  Association studies were identified from the databases of PubMed, Embase, and Cochrane Library as of March 1, 2012, and eligible investigations were synthesized using the meta-analysis method. Results were expressed with odds ratios (OR) for dichotomous data, and 95% confidence intervals (CI) were also calculated.
  
  
  RESULTS
  Six investigations were identified for the analysis of association between the prohibitin 3' untranslated region C > T gene polymorphism and cancer risk, covering of 1,461 patients with cancer and 1,197 controls. There was a positive association between the T allele and cancer susceptibility (OR=1.20, 95% CI: 1.03-1.39, P=0.02), and CC homozygous might play a protective role (OR=0.80, 95% CI: 0.68-6.11, P=0.95). In the sub-group analysis, prohibitin 3' untranslated region C > T gene polymorphism and cancer risk appeared associated with the risk of breast cancer, but not ovarian cancer.
  
  
  CONCLUSIONS
  Our results indicate that T allele is a significant genetic molecular marker to predict cancer susceptibility and CC genotype is protective, especially for breast cancer. However, more investigations are required to further clarify the association of the prohibitin 3' untranslated region C > T gene polymorphism with cancer susceptibility.
authors.affiliation: Department of Experimental Pathology, The Affiliated Tumor Hospital of Guangxi Medical University, Nanning, China.
authors.forename: Tian-Biao
authors.initials: TB
authors.lastname: Zhou
authors.forename: Sheng-Sheng
authors.initials: SS
authors.lastname: Yin
authors.forename: Jian-Jian
authors.initials: JJ
authors.lastname: Huang
authors.forename: Chao
authors.initials: C
authors.lastname: Ou
mesh_terms: D020413:3' Untranslated Regions; D000483:Alleles; D016022:Case-Control Studies; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006720:Homozygote; D006801:Humans; D009369:Neoplasms / Q000235:genetics*; D016017:Odds Ratio; D020641:Polymorphism, Single Nucleotide; D000091402:Prohibitins; D012097:Repressor Proteins / Q000235:genetics*; D012306:Risk
chemical_list: D020413:3' Untranslated Regions; D000091402:Prohibitins; D012097:Repressor Proteins