title: Catheter-directed thrombolysis in inflammatory bowel diseases: report of a case.
abstract: In patients with inflammatory bowel diseases (IBD) the prevalence of thrombosis is 6.2%, the average incidence of thromboembolism (TE) is 3.6 times higher compared to normal population. The TE is a common extraintestinal complication of IBD, squarely associated with the IBD activity. The application of anticoagulant and thrombolytic therapy in severe IBD is an unresolved issue. Herein we report the first case in literature of an active IBD patient with an upper limb acute arterial occlusion and successful catheter-directed thrombolysis (CDT). A 46-year-old male patient is reported who had Crohn's disease for 10 years. His right hand suddenly became cold and painful. Angiography proved acute occlusion of the brachial and radial artery. Vascular surgery intervention was not applicable. Endoscopy showed extended, severe inflammation of the colon. Despite the severe endoscopic findings, frequent bloody stools and moderate anaemia, CDT with recombinant tissue plasminogen activator was performed. The control angiography proved improvement, the radial artery pulse appeared. No bleeding complication was observed. This case supports that CDT-after careful estimation of the bleeding risk-can be effective and safe in patients with severe or life-threatening TE and active IBD.
authors.affiliation: 2nd Department of Medicine, Medical and Health Science Centre, University of Debrecen, 4032 Debrecen, Hungary.
authors.forename: Péter
authors.initials: P
authors.lastname: Ilonczai
authors.forename: Judit
authors.initials: J
authors.lastname: Tóth
authors.forename: László
authors.initials: L
authors.lastname: Tóth
authors.forename: István
authors.initials: I
authors.lastname: Altorjay
authors.forename: Zoltán
authors.initials: Z
authors.lastname: Boda
authors.forename: Károly
authors.initials: K
authors.lastname: Palatka
mesh_terms: D057785:Catheters; D006801:Humans; D015212:Inflammatory Bowel Diseases / Q000150:complications*; D008297:Male; D008875:Middle Aged; D013923:Thromboembolism / Q000628:therapy*; D010959:Tissue Plasminogen Activator / Q000008:administration & dosage*
chemical_list: D010959:Tissue Plasminogen Activator