title: Relationship of fat distribution with adipokines in patients with acquired immunodeficiency virus infection.
abstract: BACKGROUND
  The aim was to examine the relationship of fat distributions with adipokines concentrations in HIV-infected patients.
  
  
  METHODS
  This was a cross-sectional analysis of 36 HIV (free of lipodystrophy) infected patients. Dual-energy X-ray absorptiometry was used.
  
  
  RESULTS
  In the multivariate analysis, basal adiponectin concentration was a dependent variable, whereas waist to hip ratio and abdominal fat mass were independent predictors in the model (F = 5.1; P < 0.05). Adiponectin concentration decreases by 5.541.2 μg/ml (CI 95%: 8,071.9-3,029.1) for each unit of waist to hip ratio and 561.9 ng/ml (CI 95%: 918.2-213.4) for each kilogram of fat mass of abdominal area. In the multivariate analysis, basal leptin concentration was a dependent variable, whereas waist circumference remained an independent predictor in the model (F = 6.3; P < 0.05), with a direct correlation. Leptin concentration increases by 0.067 ng/ml (CI 95%: 0.001-0.12) for each centimeter of waist circumference.
  
  
  CONCLUSIONS
  Leptin and adiponectin are related with adiposity in HIV-infected patients.
authors.affiliation: Facultad de Medicina, Centro de Investigacion en Endocrinologia y Nutricion Clinica-I.E.N, Unit of Investigation Hospital Universitario Rio Hortega, Valladolid, Spain. dadluis@yahoo.es
authors.forename: Daniel A
authors.initials: DA
authors.lastname: de Luis
authors.forename: Pablo
authors.initials: P
authors.lastname: Bachiller
authors.forename: Teresa
authors.initials: T
authors.lastname: Palacios
authors.forename: Rosa
authors.initials: R
authors.lastname: Conde
authors.forename: Olatz
authors.initials: O
authors.lastname: Izaola
authors.forename: Beatriz
authors.initials: B
authors.lastname: de la Fuente
authors.forename: Jose M
authors.initials: JM
authors.lastname: Eiros Bouza
mesh_terms: D015502:Absorptiometry, Photon; D054392:Adipokines / Q000097:blood* / Q000378:metabolism; D000273:Adipose Tissue / Q000378:metabolism*; D050154:Adiposity; D000328:Adult; D050218:Body Fat Distribution; D015992:Body Mass Index; D003430:Cross-Sectional Studies; D005260:Female; D015658:HIV Infections / Q000097:blood* / Q000378:metabolism; D006801:Humans; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D018709:Statistics, Nonparametric; D049629:Waist-Hip Ratio
chemical_list: D054392:Adipokines