title: Double-walled hollow polymeric microspheres with independent pH and temperature dual-responsive and magnetic-targeting function from onion-shaped core-shell structures.
abstract: The magnetic-targeting stimuli-responsive hollow polymeric microspheres show unique performance as the intelligent carriers for the site specific controlled delivery of drugs or genes. In the work, the well-defied dual-responsive double-walled hollow microspheres with movable magnetic cores were prepared from the penta-layer onion-shaped core-shell microspheres. Their double-walled shells were independent, with the pH-responsive crosslinked poly(methacrylic acid) (PMAA) layer as the inner shell and the temperature responsive crosslinked poly(N-isopropylacrylamide) (PNIPAM) layer as the outer shell. The combination of the pH and temperature dual-responsive and the magnetic-targeting function make the hollow microspheres to be the most promising intelligent carriers in the biomedical fields.
authors.affiliation: State Key Laboratory of Applied Organic Chemistry and Institute of Polymer Science and Engineering, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou 730000, People's Republic of China.
authors.forename: Pengcheng
authors.initials: P
authors.lastname: Du
authors.forename: Tingmei
authors.initials: T
authors.lastname: Wang
authors.forename: Peng
authors.initials: P
authors.lastname: Liu
mesh_terms: D000178:Acrylamides / Q000737:chemistry; D000180:Acrylic Resins; D016503:Drug Delivery Systems; D006863:Hydrogen-Ion Concentration; D008863:Microspheres; D011108:Polymers / Q000737:chemistry; D011109:Polymethacrylic Acids / Q000737:chemistry; D013696:Temperature
chemical_list: D000178:Acrylamides; D000180:Acrylic Resins; D011108:Polymers; D011109:Polymethacrylic Acids; C030613:polymethacrylic acid; C052970:poly-N-isopropylacrylamide