title: [Research progress of abnormal phosphorylation of microtubule-associated tau protein and of the targeted inhibition of the phosphorylation].
abstract: Progressive dementia is described as the first and most prominent symptom of Alzheimer's disease (AD), and hyperphosphorylation of microtubule associated Tau protein (MAPT) plays a key role in neurodegeneration and neuronal dysfunction in AD and other neurodegenerative diseases. This paper reviews several protein kinases and phosphatases which can phosphorylate/dephosphorylate Tau protein, and evaluates a therapeutic strategy based on targeted inhibition of Tau kinases and activation of Tau phosphatases.
authors.affiliation: School of Physical Education, Nanchang Hangkong University, Nanchang 330063, China.
authors.forename: Futao
authors.initials: F
authors.lastname: Zhou
authors.forename: Shuangrong
authors.initials: S
authors.lastname: Chen
authors.forename: Xuechuan
authors.initials: X
authors.lastname: Sun
mesh_terms: D000544:Alzheimer Disease / Q000378:metabolism / Q000503:physiopathology; D038362:Glycogen Synthase Kinase 3 / Q000037:antagonists & inhibitors* / Q000378:metabolism; D006801:Humans; D019636:Neurodegenerative Diseases / Q000378:metabolism* / Q000503:physiopathology; D010744:Phosphoric Monoester Hydrolases / Q000378:metabolism*; D010766:Phosphorylation; D011494:Protein Kinases / Q000378:metabolism; D016875:tau Proteins / Q000737:chemistry / Q000378:metabolism* / Q000502:physiology*
chemical_list: C054369:MAPT protein, human; D016875:tau Proteins; D011494:Protein Kinases; D038362:Glycogen Synthase Kinase 3; C080888:tau-protein kinase; D010744:Phosphoric Monoester Hydrolases