title: High-risk ALK negative anaplastic large-cell lymphoma presenting with hypereosinophilic syndrome in a 2.5-year-old child.
abstract: The hypereosinophilic syndromes (HES) are characterized by prolonged nonreactive peripheral blood hypereosinophilia with tissue damage. The lymphocytic HES variant can precede malignant clonal T-cell disease in adults but it is extremely rare to be the presenting feature of lymphomas in children. Here we present a 2.5-year-old boy with HES and mediastinal T-cell anaplastic lymphoma kinase (ALK) negative systemic anaplastic large-cell lymphoma. Mature and immature eosinophils without blasts were shown on bone marrow aspiration while biopsy revealed malignant infiltration. The patient responded well to initial corticosteroid therapy, but high-risk features make a challenge of finding the cure in this extremely rare case.
authors.affiliation: Department of Pediatric Oncology, Gazi University, Ankara, Turkey. tekkesinfunda@gmail.com
authors.forename: Funda
authors.initials: F
authors.lastname: Tekkeşin
authors.forename: Faruk Güçlü
authors.initials: FG
authors.lastname: Pınarlı
authors.forename: Zühre
authors.initials: Z
authors.lastname: Kaya
authors.forename: Aynur
authors.initials: A
authors.lastname: Oğuz
authors.forename: Ceyda
authors.initials: C
authors.lastname: Karadeniz
authors.forename: Arzu
authors.initials: A
authors.lastname: Okur
authors.forename: Nalan
authors.initials: N
authors.lastname: Akyürek
mesh_terms: D000305:Adrenal Cortex Hormones / Q000008:administration & dosage; D000077548:Anaplastic Lymphoma Kinase; D044963:Biopsy, Fine-Needle; D002675:Child, Preschool; D004804:Eosinophils / Q000473:pathology*; D006801:Humans; D017681:Hypereosinophilic Syndrome / Q000188:drug therapy / Q000473:pathology*; D017728:Lymphoma, Large-Cell, Anaplastic / Q000188:drug therapy / Q000473:pathology*; D008297:Male; D008479:Mediastinal Neoplasms / Q000188:drug therapy / Q000473:pathology*; D020794:Receptor Protein-Tyrosine Kinases
chemical_list: D000305:Adrenal Cortex Hormones; C000626173:ALK protein, human; D000077548:Anaplastic Lymphoma Kinase; D020794:Receptor Protein-Tyrosine Kinases