title: Prospective evaluation of a 5 × 4 Gy prescription for palliation of canine nasal tumors.
abstract: We evaluated the efficacy of palliative radiation therapy using 5 × 4 Gy given daily in 18 dogs with nasal tumors. Dogs with malignant nasal tumors were evaluated for response rate, response duration, and survival. Seventy-eight percent of the dogs achieved complete resolution of clinical signs, and 16.5% had partial resolution of their signs. Overall median response duration for all dogs was 178 days after one course of radiation therapy. Six dogs received a second course of therapy when their disease progressed using the same daily 5 × 4 Gy scheme, and all six responded for a median time of 129.5 days for an overall median survival time in these six dogs of 309 days. Based on these results, a radiation prescription of 5 × 4 Gy appears to be useful palliatively in dogs with a malignant nasal tumor.
authors.affiliation: Veterinary Cancer Group, Culver City, CA 90232, USA. tancoleman103@sbcglobal.net
authors.forename: Birgitte
authors.initials: B
authors.lastname: Tan-Coleman
authors.forename: Jarred
authors.initials: J
authors.lastname: Lyons
authors.forename: Craig
authors.initials: C
authors.lastname: Lewis
authors.forename: Mona
authors.initials: M
authors.lastname: Rosenberg
authors.forename: Azucena
authors.initials: A
authors.lastname: Ruiz
mesh_terms: D000818:Animals; D004283:Dog Diseases / Q000401:mortality / Q000532:radiotherapy*; D004285:Dogs; D019583:Dose Fractionation, Radiation; D005260:Female; D008297:Male; D009669:Nose Neoplasms / Q000401:mortality / Q000532:radiotherapy / Q000662:veterinary*; D010166:Palliative Care; D011446:Prospective Studies; D016019:Survival Analysis; D013997:Time Factors; D016896:Treatment Outcome