title: [A case of poorly-differentiated neuroendocrine carcinoma of the ascending colon with multiple liver metastases successfully treated with cisplatin and irinotecan].
abstract: A 74-year-old woman diagnosed with poorly-differentiated neuroendocrine carcinoma originating from the ascending colon was referred to our hospital. She had felt anorexia, abdominal pains and her (ECOG) performance status was 3. Her CT scan showed that some abdominal lymph nodes were swelling and that there were many metastatic lesions occupying most of the liver. We started chemotherapy with cisplatin and irinotecan according to a regimen for small cell lung cancer. Considering her poor PS, both of the drugs were administered at 30mg/m² twice 4 weeks in the first course of chemotherapy. Her anorexia and abdominal pains immediately disappeared, and CT scan showed that all of the metastases were decreased in size. After 4 courses, however, some of the metastatic lesions were increased in size. She died 8 months after diagnosis. The tumor marker doubling time was 17 days.
authors.affiliation: Cancer Center, Kanazawa University Hospital.
authors.forename: Kaname
authors.initials: K
authors.lastname: Yamashita
authors.forename: Daisuke
authors.initials: D
authors.lastname: Ishikawa
authors.forename: Shigeki
authors.initials: S
authors.lastname: Nanjo
authors.forename: Shinji
authors.initials: S
authors.lastname: Takeuchi
authors.forename: Tadaaki
authors.initials: T
authors.lastname: Yamada
authors.forename: Hisatsugu
authors.initials: H
authors.lastname: Mouri
authors.forename: Koushiro
authors.initials: K
authors.lastname: Ohtsubo
authors.forename: Kazuo
authors.initials: K
authors.lastname: Yasumoto
authors.forename: Masashi
authors.initials: M
authors.lastname: Kumagai
authors.forename: Yoshimichi
authors.initials: Y
authors.lastname: Ueda
authors.forename: Seiji
authors.initials: S
authors.lastname: Yano
mesh_terms: D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D002166:Camptothecin / Q000008:administration & dosage / Q000031:analogs & derivatives; D018278:Carcinoma, Neuroendocrine / Q000188:drug therapy* / Q000473:pathology; D002454:Cell Differentiation; D002945:Cisplatin / Q000008:administration & dosage; D044682:Colon, Ascending / Q000473:pathology*; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D000077146:Irinotecan; D008113:Liver Neoplasms / Q000188:drug therapy* / Q000556:secondary; D014057:Tomography, X-Ray Computed
chemical_list: D000077146:Irinotecan; D002945:Cisplatin; D002166:Camptothecin