title: Chemical constituents from Brucea javanica.
abstract: Fourteen apotirucallane-type triterpenoids, named brujavanones A-N, were isolated from the twigs of Brucea javanica, along with four known quassinoids and seven known lignans from the seeds of B. javanica. Their structures were elucidated on the basis of extensive spectroscopic data analysis. The structure of a previously reported triterpenoid, bruceajavanin C, was revised as its C-21 epimer. The cytotoxic activities of triterpenoids and quassinoids against two human tumor cell lines, HL-60 and A-549, were evaluated, but all the compounds were inactive (IC₅₀>10 μM).
authors.affiliation: State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zu Chong Zhi Road, Shanghai 201203, People's Republic of China.
authors.forename: Shi-Hui
authors.initials: SH
authors.lastname: Dong
authors.forename: Jia
authors.initials: J
authors.lastname: Liu
authors.forename: Ying-Zi
authors.initials: YZ
authors.lastname: Ge
authors.forename: Lei
authors.initials: L
authors.lastname: Dong
authors.forename: Cheng-Hui
authors.initials: CH
authors.lastname: Xu
authors.forename: Jian
authors.initials: J
authors.lastname: Ding
authors.forename: Jian-Min
authors.initials: JM
authors.lastname: Yue
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry / Q000494:pharmacology*; D032269:Brucea / Q000737:chemistry*; D045744:Cell Line, Tumor; D002470:Cell Survival; D006801:Humans; D020128:Inhibitory Concentration 50; D015394:Molecular Structure; D014315:Triterpenes / Q000737:chemistry* / Q000494:pharmacology*
chemical_list: D000970:Antineoplastic Agents; D014315:Triterpenes; C541579:bruceajavanin C