title: Occludin dislocation in brain capillary endothelium of rats with bile duct ligation induced cholestasis.
abstract: The present study used a rat model with bile duct ligation to examine the effect of cholestasis, to the localization of occludin in brain capillary endothelium by means of electronic microscopy. The results demonstrated a dislocation of occludin away from the tight junction sites of brain endothelial cells. A significant increase of the occludin-interendothelial cleft distance was demonstrated in the midbrain and the cerebellum samples but not in the frontal cortex, compared to the control group samples. These findings imply a brain region selective derangement of occludin in response to liver disease.
authors.affiliation: Department of Neurosurgery, School of Medicine, University of Patras, Patras, Greece.
authors.forename: Adamantios G
authors.initials: AG
authors.lastname: Mavrakis
authors.forename: Sophia
authors.initials: S
authors.lastname: Havaki
authors.forename: Evangelos
authors.initials: E
authors.lastname: Marinos
authors.forename: Elisabeth
authors.initials: E
authors.lastname: Chroni
authors.forename: Dimitris
authors.initials: D
authors.lastname: Konstantinou
mesh_terms: D000818:Animals; D001652:Bile Ducts; D001921:Brain / Q000098:blood supply* / Q000648:ultrastructure; D002196:Capillaries / Q000378:metabolism*; D002779:Cholestasis / Q000209:etiology / Q000378:metabolism*; D004730:Endothelium, Vascular / Q000378:metabolism*; D008026:Ligation; D008297:Male; D008854:Microscopy, Electron; D062793:Occludin / Q000378:metabolism*; D021381:Protein Transport; D051381:Rats; D017208:Rats, Wistar
chemical_list: D062793:Occludin