title: [A new approach to the electrostatic stabilization of cations in the aqueous cavity of K+ channel: the role of nonlocal-electrostatic effects].
abstract: Methods of nonlocal electrostatics, applied to ion channels in our previous papers, are used to analyze the stability of K+ in the aqueous cavity of K+ channel. Other authors used formulas of classical electrostatics to calculate the energy of K+ in the aqueous cavity of KcsA. Using a new formulation of nonlocal-electrostatic theory, we obtained a formula for the image force energy acting on K+, which is in the center of a spherical cavity of K+ channel. It is shown that nonlocal-electrostatic effects in the aqueous cavity of K+ channel leads to a decrease in the energy K+ on 4kT compared with the calculation by the formulas of classical electrostatics.
authors.forename: A A
authors.initials: AA
authors.lastname: Rubashkin
authors.forename: P
authors.initials: P
authors.lastname: Iserovich
mesh_terms: D002412:Cations; D008956:Models, Chemical; D011188:Potassium / Q000737:chemistry; D015221:Potassium Channels / Q000737:chemistry*; D055672:Static Electricity; D014867:Water / Q000737:chemistry*
chemical_list: D002412:Cations; D015221:Potassium Channels; D014867:Water; D011188:Potassium