title: Association between timed up-and-go and memory, executive function, and processing speed.
abstract: OBJECTIVE
  To determine which cognitive tests are independently associated with performance on the Timed Up-and-Go Test (TUG).
  
  
  METHODS
  Data were obtained from Wave 1 of The Irish Longitudinal Study on Ageing (TILDA), a population-based study assessing health, economic, and social aspects of aging.
  
  
  METHODS
  Community-dwelling adults completed a home based interview and a health center-based assessment.
  
  
  METHODS
  TILDA participants aged 50 and older with a Mini-Mental State Examination (MMSE) score of 10 or greater (N = 4,998).
  
  
  METHODS
  Participants completed a battery of cognitive assessments including the Montreal Cognitive Assessment (MoCA), Color Trails Test, word and letter fluency, choice reaction time, sustained attention, prospective memory, word recall, and picture memory. Linear regression was used to determine univariate and multivariate associations between TUG and each cognitive test.
  
  
  RESULTS
  Slower TUG time was associated with poorer performance on all cognitive tests in univariate analysis (P < .05). In multivariate analysis, poorer performance on the MoCA, letter fluency, Color Trail 1, cognitive reaction time, mean sustained attention response time, and prospective memory were independently associated with slower TUG time (P < .05).
  
  
  CONCLUSIONS
  Slower TUG time is independently associated with poorer performance on global cognition, executive function, and memory tests and slower processing speed. This highlights that TUG is more than just a simple mobility task and suggests that a comprehensive cognitive assessment is important for individuals with mobility difficulties.
authors.affiliation: The Irish Longitudinal Study on Ageing, Trinity College Dublin, Dublin, Ireland. odonogh@tcd.ie
authors.forename: Orna A
authors.initials: OA
authors.lastname: Donoghue
authors.forename: N Frances
authors.initials: NF
authors.lastname: Horgan
authors.forename: George M
authors.initials: GM
authors.lastname: Savva
authors.forename: Hilary
authors.initials: H
authors.lastname: Cronin
authors.forename: Claire
authors.initials: C
authors.lastname: O'Regan
authors.forename: Rose Anne
authors.initials: RA
authors.lastname: Kenny
mesh_terms: D000368:Aged; D000375:Aging / Q000502:physiology*; D003072:Cognition Disorders / Q000175:diagnosis* / Q000503:physiopathology*; D015897:Comorbidity; D004185:Disability Evaluation; D056344:Executive Function / Q000502:physiology*; D005260:Female; D015577:Geriatric Assessment; D006801:Humans; D007494:Ireland; D016014:Linear Models; D008137:Longitudinal Studies; D008297:Male; D008569:Memory Disorders / Q000175:diagnosis* / Q000503:physiopathology*; D008875:Middle Aged; D051346:Mobility Limitation; D009483:Neuropsychological Tests; D011446:Prospective Studies