title: Otitis media in infancy and the development of asthma and atopic disease.
abstract: Otitis media is a frequent respiratory infection of early childhood and it is important to fully understand the long-term complications and sequelae. Literature examining otitis media in early childhood and subsequent development of atopic disease is sparse despite there being vast literature on the association between respiratory infections and atopic disease. Current data support the hypothesis that otitis media infections in early life, especially frequent or severe infections, influence the developing immune system, resulting in increased risk for asthma. Recent findings have also reported an association between otitis media and eczema. Atopic children and those with a family history of atopy appear to be at greater risk. Future work should investigate the specific mechanisms involved. It is possible that vaccines and preventive strategies aimed at reducing the burden of otitis media could also reduce the burden of childhood asthma and atopic disease.
authors.affiliation: Institute of Epidemiology I, German Research Center for Environmental Health, 85764, Neuherberg, Germany. elaina.macintyre@gmail.com
authors.forename: Elaina A
authors.initials: EA
authors.lastname: MacIntyre
authors.forename: Joachim
authors.initials: J
authors.lastname: Heinrich
mesh_terms: D017677:Age Distribution; D017668:Age of Onset; D001249:Asthma / Q000453:epidemiology*; D002648:Child; D002675:Child, Preschool; D015331:Cohort Studies; D015897:Comorbidity; D004485:Eczema / Q000453:epidemiology; D006801:Humans; D006969:Hypersensitivity, Immediate / Q000453:epidemiology*; D015994:Incidence; D007223:Infant; D010033:Otitis Media / Q000453:epidemiology*; D012141:Respiratory Tract Infections / Q000453:epidemiology*; D006255:Rhinitis, Allergic, Seasonal / Q000453:epidemiology; D012307:Risk Factors