title: Adverse neuropsychiatric events associated with varenicline use in veterans: a case series.
abstract: Varenicline represents a major advance in the treatment of nicotine addiction and has been shown to be safe and effective to promote abstinence. However, in a small number of patients, neuropsychiatric adverse events and worsening of underlying psychiatric conditions have been reported. As the veteran population has higher rates of co-morbid psychiatric conditions and nicotine dependence this population may be at higher risk for serious adverse effects to varenicline warranting close monitoring. Herein we report seven cases of varenicline associated neuropsychiatric adverse events and describe an institutional response to adequately monitor patients to ensure safety and efficacy.
authors.affiliation: Iowa City VA Health Care System, Iowa City, Iowa 52236, USA. matthew-cantrell@uiowa.edu
authors.forename: Matthew
authors.initials: M
authors.lastname: Cantrell
authors.forename: Tami
authors.initials: T
authors.lastname: Argo
authors.forename: Lauren
authors.initials: L
authors.lastname: Haak
authors.forename: Laurel
authors.initials: L
authors.lastname: Janney
mesh_terms: D000328:Adult; D001552:Benzazepines / Q000009:adverse effects*; D001714:Bipolar Disorder / Q000453:epidemiology; D015897:Comorbidity; D003866:Depressive Disorder / Q000139:chemically induced* / Q000453:epidemiology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D018722:Nicotinic Agonists / Q000009:adverse effects*; D011810:Quinoxalines / Q000009:adverse effects*; D016540:Smoking Cessation; D013313:Stress Disorders, Post-Traumatic / Q000453:epidemiology; D059020:Suicidal Ideation; D014029:Tobacco Use Disorder / Q000188:drug therapy / Q000453:epidemiology; D014481:United States / Q000453:epidemiology; D000068580:Varenicline; D014728:Veterans / Q000523:psychology
chemical_list: D001552:Benzazepines; D018722:Nicotinic Agonists; D011810:Quinoxalines; D000068580:Varenicline