title: Genetic variants in epoxide hydrolases modify the risk of oligozoospermia and asthenospermia in Han-Chinese population.
abstract: OBJECTIVE
  Epoxide hydrolases are involved in detoxifying and excreting the environmental chemicals, which are associated with decreased semen quality and male infertility. We hypothesized that polymorphisms in epoxide hydrolases may be associated with risk of oligozoospermia and asthenospermia.
  
  
  METHODS
  In this study, 468 fertile controls and 672 idiopathic male infertile patients were recruited. SNPstream and TaqMan assay were used to genotype four single nucleotide polymorphisms in EPHX1 and EPHX2. The semen analysis was performed by computer-assisted semen analysis system.
  
  
  RESULTS
  Our results demonstrated that rs1042064 of EPHX2 was significantly associated with decreased risk of oligozoospermia (OR=0.65, 95% CI: 0.44-0.98) and asthenospermia (OR=0.66, 95% CI: 0.46-0.94).
  
  
  CONCLUSIONS
  Our results provided evidence that genetic variants in epoxide hydrolases may modify the risk of oligozoospermia and asthenospermia in Han-Chinese population.
authors.affiliation: State Key Laboratory of Reproductive Medicine, Institute of Toxicology, Nanjing Medical University, Nanjing 210029, China.
authors.forename: Yufeng
authors.initials: Y
authors.lastname: Qin
authors.forename: Xiumei
authors.initials: X
authors.lastname: Han
authors.forename: Yuzhu
authors.initials: Y
authors.lastname: Peng
authors.forename: Rong
authors.initials: R
authors.lastname: Shen
authors.forename: Xirong
authors.initials: X
authors.lastname: Guo
authors.forename: Li
authors.initials: L
authors.lastname: Cao
authors.forename: Ling
authors.initials: L
authors.lastname: Song
authors.forename: Jiahao
authors.initials: J
authors.lastname: Sha
authors.forename: Yankai
authors.initials: Y
authors.lastname: Xia
authors.forename: Xinru
authors.initials: X
authors.lastname: Wang
mesh_terms: D000328:Adult; D044466:Asian People / Q000235:genetics*; D053627:Asthenozoospermia / Q000235:genetics*; D004851:Epoxide Hydrolases / Q000235:genetics* / Q000378:metabolism; D006801:Humans; D008297:Male; D009845:Oligospermia / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide
chemical_list: D004851:Epoxide Hydrolases; C506428:EPHX2 protein, human; C522330:EPHX1 protein, human