title: The association of anti-glutamic acid decarboxylase antibodies with different neurological findings in childhood.
abstract: Glutamic acid decarboxylase antibodies can rarely be associated with various neurological syndromes, which are usually present in adults. Here, we present 2 affected children. Our first patient had a diagnosis of epilepsy and presented with continuous involuntary movements and multifocal myoclonic seizures following an infection at the age of 9 months. Anti-glutamic acid decarboxylase antibodies were found in the serum and cerebrospinal fluid. A partial response was obtained from intravenous immunoglobulin, steroid, and plasmapheresis treatment. The other patient presented with a clinical picture of acute cerebellar ataxia and mutism at the age of 6 years and recovered fully following intravenous immunoglobulin treatment. Neurological findings due to anti-glutamic acid decarboxylase antibodies may be more common in children than previously thought, and achieving an early diagnosis can be important for prompt treatment.
authors.affiliation: Department of Pediatric Neurology, Dr. Sami Ulus Children's Health and Diseases Training and Research Hospital, Ankara, Turkey. mehparekafali@gmail.com
authors.forename: Mehpare
authors.initials: M
authors.lastname: Ozkan
authors.forename: Ayşe
authors.initials: A
authors.lastname: Aksoy
authors.forename: Funda
authors.initials: F
authors.lastname: Çenesiz
authors.forename: Nilgün Erkek
authors.initials: NE
authors.lastname: Atay
authors.forename: Deniz
authors.initials: D
authors.lastname: Yüksel
mesh_terms: D000906:Antibodies / Q000097:blood*; D002648:Child; D004569:Electroencephalography; D004827:Epilepsy / Q000097:blood* / Q000150:complications* / Q000175:diagnosis; D005968:Glutamate Decarboxylase / Q000276:immunology*; D006801:Humans; D007223:Infant; D008297:Male; D009422:Nervous System Diseases / Q000145:classification / Q000209:etiology*
chemical_list: D000906:Antibodies; D005968:Glutamate Decarboxylase