title: [Innate and adaptative immunity of the female genital tract].
abstract: Most of molecules and cells involved in both types, innate and adaptive immunity are present within the feminine genital tract. This article attempts to list some of the various actors involved in these immunities, essentially at the vaginal level and to illustrate their implications in the most frequent pathologies. Among these molecules: defensins, collectins lysozyme, lactoferrin, calprotectin, SLP1, HSP and many others as well as Toll receptors and immunoglobulins (IgG and IgA) play a major role. Epithelial cells, antigen presenting cells, lymphocytes T, B, NK also contribute efficiently to the defenses in a coordinated way partially under the influence of sex hormones. The therapeutic perspectives, of which vaccines are briefly mentioned.
authors.affiliation: Faculté de médecine de Toulouse Rangueil, université Paul-Sabatier, Toulouse, France. jp.lepargneur@free.fr
authors.forename: J-P
authors.initials: JP
authors.lastname: Lepargneur
authors.forename: M
authors.initials: M
authors.lastname: Abbal
mesh_terms: D056704:Adaptive Immunity; D000938:Antigen-Presenting Cells / Q000276:immunology; D037222:Collectins / Q000276:immunology; D004848:Epithelium / Q000276:immunology; D005260:Female; D005836:Genitalia, Female / Q000276:immunology*; D006801:Humans; D007109:Immunity; D007136:Immunoglobulins / Q000276:immunology; D008214:Lymphocytes / Q000276:immunology; D051193:Toll-Like Receptors / Q000502:physiology; D014621:Vagina / Q000276:immunology / Q000378:metabolism; D014623:Vaginal Diseases / Q000276:immunology / Q000382:microbiology / Q000821:virology
chemical_list: D037222:Collectins; D007136:Immunoglobulins; D051193:Toll-Like Receptors