title: [Epidemiological studies on mtDNA 12S rRNA A1555G mutation of 10 non syndromic hearing loss families in Yunnan province].
abstract: OBJECTIVE
  To investigate the meaning of the mutation screening, prevalence, inheritance and the intervention or the prevention for the specific drugs in 10 families with non-syndrome hearing loss in Yunnan Province, China.
  
  
  METHODS
  To do a questionnaire about the cases of ten families with non-syndrome hearing loss and to draw a detailed matriarchal family tree detailed. Following that, the A1555G mutation-positive individuals were detected and confirmed using DNA extracting, PCR amplification and sequencing for family volunteer.
  
  
  RESULTS
  There are 96 members have attended the blood collection in these ten families. Thirty-six of them had the normal hearing and 60 of them had the sensory neural hearing loss. However, 4 out of those had no A1555G point mutation, and 92 had A1555G point mutation (95.8%). While 7 of those were Heterogeneity, the rest were all homogeneous mutation. There were also 73 patients who had amino glycoside antibiotic medication history. However all the rest cases had a history of amino glycoside antibiotic medication were not clear yet.
  
  
  CONCLUSIONS
  The proportion of patients with drug-induced deafness is high in Yunnan province and the mutation rate of mitochondrial DNA A1555G is also high. It is worthy to do DNA 12SrRNA A1555G mutation screening for drug intervention and prevention.
authors.affiliation: Department of Otorhinolaryngology-Head and Neck Surgery, People's Hospital of Ningxia, Yinchuan 750021, China.
authors.forename: Tao
authors.initials: T
authors.lastname: Ma
authors.forename: Xijun
authors.initials: X
authors.lastname: Xue
authors.forename: Pu
authors.initials: P
authors.lastname: Dai
authors.forename: Xianbao
authors.initials: X
authors.lastname: Cao
authors.forename: Jun
authors.initials: J
authors.lastname: Chi
authors.forename: Jiahong
authors.initials: J
authors.lastname: Deng
authors.forename: Kang
authors.initials: K
authors.lastname: Pang
authors.forename: Weimin
authors.initials: W
authors.lastname: Liu
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D002681:China / Q000453:epidemiology; D004252:DNA Mutational Analysis; D004272:DNA, Mitochondrial / Q000235:genetics*; D003638:Deafness / Q000453:epidemiology* / Q000235:genetics*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010375:Pedigree; D017354:Point Mutation; D012335:RNA, Ribosomal / Q000235:genetics*; D055815:Young Adult
chemical_list: D004272:DNA, Mitochondrial; D012335:RNA, Ribosomal; C075526:RNA, ribosomal, 12S