title: [Polymorphism of genes of the system of biotransformation of xenobiotics in patients with occupational allergic dermatoses].
abstract: Evaluation of genes polymorphic system of xenobiotics biotransformation in patients with occupational allergodermatoses showed significantly higher percentage of incidence of polymorphic variants of genes CYP 1A1 *2C and EPHX1 AND-415G compared with population control. A combination of 3 or more adverse hetero--and homozygous gene alleles CYP 1A1, CYP3A4, EPHX1 and deletions of genes GSTM1 and GSTT1, is characterized by earlier (with the experience of work in harmful conditions up to 5 years) development, severe and unfavorable prognosis of occupational pathology of the skin.
authors.forename: N F
authors.initials: NF
authors.lastname: Izmerov
authors.forename: L P
authors.initials: LP
authors.lastname: Kuz'mina
authors.forename: M M
authors.initials: MM
authors.lastname: Koliaskina
authors.forename: L M
authors.initials: LM
authors.lastname: Bezrukavnikova
authors.forename: N A
authors.initials: NA
authors.lastname: Lazarashvili
authors.forename: Ia A
authors.initials: IaA
authors.lastname: Petinati
mesh_terms: D000328:Adult; D059366:Asthma, Occupational / Q000139:chemically induced / Q000235:genetics; D001711:Biotransformation / Q000235:genetics*; D015897:Comorbidity; D017449:Dermatitis, Allergic Contact / Q000235:genetics; D009783:Dermatitis, Occupational / Q000209:etiology / Q000235:genetics; D004485:Eczema / Q000139:chemically induced / Q000235:genetics; D005260:Female; D059647:Gene-Environment Interaction; D020022:Genetic Predisposition to Disease; D055106:Genome-Wide Association Study; D006801:Humans; D008297:Male; D011110:Polymorphism, Genetic; D011379:Prognosis; D013997:Time Factors; D015262:Xenobiotics / Q000009:adverse effects / Q000493:pharmacokinetics
chemical_list: D015262:Xenobiotics