title: Organocatalytic aza-Michael-Michael cascade reactions: a flexible approach to 2,3,4-trisubstituted tetrahydroquinolines.
abstract: Cascading like dominos: An efficient and highly enantioselective synthesis of 2,3,4-trisubstituted tetrahydroquinolines through cascade aza-Michael-Michael reactions was developed. Tetrahydroquinolines were obtained in excellent yields, high enantioselectivities, and good diastereoselectivities, and could be easily transformed into ring-fused tetrahydroquinolines (see scheme).
authors.affiliation: State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou 730000, PR China.
authors.forename: Zhen-Xin
authors.initials: ZX
authors.lastname: Jia
authors.forename: Yong-Chun
authors.initials: YC
authors.lastname: Luo
authors.forename: Yao
authors.initials: Y
authors.lastname: Wang
authors.forename: Liang
authors.initials: L
authors.lastname: Chen
authors.forename: Peng-Fei
authors.initials: PF
authors.lastname: Xu
authors.forename: Binghe
authors.initials: B
authors.lastname: Wang
mesh_terms: D002384:Catalysis; D015394:Molecular Structure; D011804:Quinolines / Q000138:chemical synthesis* / Q000737:chemistry; D013237:Stereoisomerism
chemical_list: D011804:Quinolines; C542964:1,2,3,4-tetrahydroquinoline