title: Circulating cytokine pattern and factors describing rheumatoid arthritis: IL-15 as one of the biomarkers for RA?
abstract: The aim of study was to examine relationship among levels of cytokines (IL-6, IL-13, IL-15, TNF-α) and chemokine (IL-8), production of autoantibodies, radiographic progression, and factors describing rheumatoid arthritis (RA). A total of 156 RA patients according to ACR criteria, and 55 control subjects were recruited into study. We observed higher levels of IL-15 within RA patients compared to healthy controls. Correlations among cytokine levels and the measures of rheumatoid factors, anti-CCP, measures of disease activity, and radiographic progression were observed. We conclude that IL-15 level in circulation could serve as one of the biomarkers for RA detection.
authors.affiliation: Institute of Pathological Physiology, Masaryk University, Brno, Czech Republic.
authors.forename: Monika
authors.initials: M
authors.lastname: Pavkova Goldbergova
authors.forename: Nikolas
authors.initials: N
authors.lastname: Pavek
authors.forename: Jolana
authors.initials: J
authors.lastname: Lipkova
authors.forename: Jiri
authors.initials: J
authors.lastname: Jarkovsky
authors.forename: Martina
authors.initials: M
authors.lastname: Stouracova
authors.forename: Jindra
authors.initials: J
authors.lastname: Gatterova
authors.forename: Anna
authors.initials: A
authors.lastname: Vasku
authors.forename: Miroslav
authors.initials: M
authors.lastname: Soucek
authors.forename: Petr
authors.initials: P
authors.lastname: Nemec
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001172:Arthritis, Rheumatoid / Q000097:blood* / Q000000981:diagnostic imaging / Q000276:immunology; D001323:Autoantibodies / Q000097:blood; D015415:Biomarkers / Q000097:blood; D016022:Case-Control Studies; D016207:Cytokines / Q000097:blood; D018450:Disease Progression; D005260:Female; D006801:Humans; D019409:Interleukin-15 / Q000097:blood*; D008297:Male; D008875:Middle Aged; D010456:Peptides, Cyclic / Q000276:immunology; D012372:ROC Curve; D011859:Radiography; D055815:Young Adult
chemical_list: D001323:Autoantibodies; D015415:Biomarkers; D016207:Cytokines; C569274:IL15 protein, human; D019409:Interleukin-15; D010456:Peptides, Cyclic; C487763:cyclic citrullinated peptide