title: A dual-targeting hybrid platinum(IV) prodrug for enhancing efficacy.
abstract: A multifunctional hybrid platinum(IV) prodrug, which consists of both the mitochondria-targeting drug DCA and the DNA-crosslinking drug cisplatin, was synthesized and tethered to a carrier polymer to further self-assemble into micelles for intracellular delivery.
authors.affiliation: State Key Laboratory of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, People's Republic of China.
authors.forename: Haihua
authors.initials: H
authors.lastname: Xiao
authors.forename: Lesan
authors.initials: L
authors.lastname: Yan
authors.forename: Yu
authors.initials: Y
authors.lastname: Zhang
authors.forename: Ruogu
authors.initials: R
authors.lastname: Qi
authors.forename: Wenliang
authors.initials: W
authors.lastname: Li
authors.forename: Rui
authors.initials: R
authors.lastname: Wang
authors.forename: Shi
authors.initials: S
authors.lastname: Liu
authors.forename: Yubin
authors.initials: Y
authors.lastname: Huang
authors.forename: Yuxin
authors.initials: Y
authors.lastname: Li
authors.forename: Xiabin
authors.initials: X
authors.lastname: Jing
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D002945:Cisplatin / Q000737:chemistry / Q000494:pharmacology*; D003432:Cross-Linking Reagents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D004247:DNA / Q000737:chemistry / Q000187:drug effects; D003999:Dichloroacetic Acid / Q000737:chemistry / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D016503:Drug Delivery Systems; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D008823:Micelles; D008928:Mitochondria / Q000187:drug effects / Q000378:metabolism; D009944:Organoplatinum Compounds / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D011355:Prodrugs / Q000138:chemical synthesis / Q000737:chemistry* / Q000378:metabolism / Q000494:pharmacology*; D013329:Structure-Activity Relationship
chemical_list: D000970:Antineoplastic Agents; D003432:Cross-Linking Reagents; D008823:Micelles; D009944:Organoplatinum Compounds; D011355:Prodrugs; D004247:DNA; D003999:Dichloroacetic Acid; D002945:Cisplatin