title: Association of catalase genotype with oxidative stress in the predication of colorectal cancer: modification by epidemiological factors.
abstract: OBJECTIVE
  This paper aims to assess the interaction between common variations in catalase (CAT) polymorphic gene and environmental factors for antioxidant defense enzyme in modulating individual susceptibility to colorectal cancer (CRC).
  
  
  METHODS
  A case-control study with 880 colorectal cancer cases and 848 controls was conducted to investigate whether variations in the catalase (CAT) gene, one of the genes involved in scavenging oxidative stress, influenced susceptibility to CRC.
  
  
  RESULTS
  The interaction between life style and genotypes as well as with their effects on colorectal cancer was deduced from the present study. Significant difference (P = 0.01) was identified in the distribution of CAT genotype between the colorectal cancer cases and the controls. The CRC cases had significantly lower mean activity than the controls (P < 0.01). Correlation analyses revealed statistically significant correlations between CAT activity and CAT genotype (P < 0.01).
  
  
  CONCLUSIONS
  The risk of CRC was associated with smoking, low vegetable consumption, high pork and poultry consumptions, and low or high BMI. This is the first study reporting an association of polymorphism CAT-21A > T with colorectal cancer. Low CAT activity was associated with an increased risk of CRC; however, no evidence was found to support an association between CAT-21A > T polymorphism and CRC risk.
authors.affiliation: Department of Laboratory Diagnosis, The First Affiliated Hospital of the Harbin Medical University, Harbin 150001, Heilongliang, China.
authors.forename: Dong
authors.initials: D
authors.lastname: Chang
authors.forename: Zhang Liang
authors.initials: ZL
authors.lastname: Hu
authors.forename: Lin
authors.initials: L
authors.lastname: Zhang
authors.forename: Ya Shuang
authors.initials: YS
authors.lastname: Zhao
authors.forename: Qing Hui
authors.initials: QH
authors.lastname: Meng
authors.forename: Qing Bai
authors.initials: QB
authors.lastname: Guan
authors.forename: Jin
authors.initials: J
authors.lastname: Zhou
authors.forename: Hong Zhi
authors.initials: HZ
authors.lastname: Pan
mesh_terms: D000328:Adult; D000368:Aged; D016022:Case-Control Studies; D002374:Catalase / Q000235:genetics*; D015179:Colorectal Neoplasms / Q000201:enzymology / Q000453:epidemiology / Q000378:metabolism*; D005260:Female; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D018384:Oxidative Stress; D016133:Polymerase Chain Reaction
chemical_list: D002374:Catalase