title: Biodegradable hyperbranched polyglycerol with ester linkages for drug delivery.
abstract: Biodegradable hyperbranched polyglycerols (dHPGs) were synthesized through oxyanionic initiating hybrid polymerization of glycerol and glycidyl methacrylate. Due to the introduction of ester linkages into the hyperbranched polyglycerol backbone, dHPGs showed good biodegradability and low cytotoxicity. Benefiting from the existence of terminal hydroxyls and methacryloyl groups, both the anticancer drug methotrexate (MTX) and fluorescent probe Rhodamine-123 could be conjugated onto the surface of dHPGs easily. The resultant MTX-conjugated polymers (dHPG-MTXs) exhibited an amphiphilic character, resulting in the formation of micelles in an aqueous solution. The release of MTX from micelles was significantly faster at mildly acidic pH of 5.0 compared to physiological pH of 7.4. dHPG-MTX micelles could be efficiently internalized by cancer cells. MTT assay against cancer cells showed dHPG-MTXs micelles had high anticancer efficacy. On the basis of their good biodegradability and low cytotoxicity, dHPGs provide an opportunity to design excellent drug delivery systems.
authors.affiliation: Department of Oral and Maxillofacial Surgery, Ninth People's Hospital, School of Stomatology, Shanghai Jiao Tong University School of Medicine, 639 Zhizaoju Road, Shanghai 200011, People's Republic of China.
authors.forename: Mei
authors.initials: M
authors.lastname: Hu
authors.forename: Mingsheng
authors.initials: M
authors.lastname: Chen
authors.forename: Guolin
authors.initials: G
authors.lastname: Li
authors.forename: Yan
authors.initials: Y
authors.lastname: Pang
authors.forename: Dali
authors.initials: D
authors.lastname: Wang
authors.forename: Jieli
authors.initials: J
authors.lastname: Wu
authors.forename: Feng
authors.initials: F
authors.lastname: Qiu
authors.forename: Xinyuan
authors.initials: X
authors.lastname: Zhu
authors.forename: Jian
authors.initials: J
authors.lastname: Sun
mesh_terms: D016475:3T3 Cells; D000818:Animals; D001692:Biological Transport; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D004337:Drug Carriers / Q000737:chemistry; D005990:Glycerol / Q000138:chemical synthesis / Q000737:chemistry* / Q000378:metabolism; D006367:HeLa Cells; D006801:Humans; D008727:Methotrexate / Q000008:administration & dosage* / Q000737:chemistry* / Q000494:pharmacology; D051379:Mice; D008823:Micelles; D011108:Polymers / Q000138:chemical synthesis / Q000737:chemistry* / Q000378:metabolism; D020112:Rhodamine 123 / Q000008:administration & dosage* / Q000737:chemistry* / Q000494:pharmacology
chemical_list: D004337:Drug Carriers; D008823:Micelles; D011108:Polymers; D020112:Rhodamine 123; C043941:polyglycerol; D005990:Glycerol; D008727:Methotrexate