title: [The treatment of chronic polypous rhinosinusitis in the postoperative period with low doses of clarithromycin].
abstract: The aim of this work was to study efficacy and safety of long-term low-dose clarithromycin therapy of chronic polypous rhinosinusitis during 6 months after endoscopic polyposinusotomy. 112 patients aged 25-65 yr were randomized in groups 7 days after surgery. Those in group 1 (n=66) received topic corticosteroid treatment in combination with clarithromycin (250 mg/day for 3 mo). The use of clarithromycin significantly decreased the number of clinical symptoms and improved quality of life. CT examination showed significant reduction in the frequency of relapses, episodes of acute respiratory viral infections, and their bacterial complications. All these effects persisted for 3 mo after withdrawal of clarithromycin.
authors.forename: T Iu
authors.initials: TIu
authors.lastname: Bobacheva
mesh_terms: D000328:Adult; D000900:Anti-Bacterial Agents / Q000008:administration & dosage; D017291:Clarithromycin / Q000008:administration & dosage*; D004305:Dose-Response Relationship, Drug; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009297:Nasal Mucosa / Q000473:pathology / Q000503:physiopathology / Q000601:surgery; D009298:Nasal Polyps / Q000473:pathology / Q000503:physiopathology / Q000628:therapy; D059747:Nasal Surgical Procedures / Q000009:adverse effects / Q000379:methods; D010256:Paranasal Sinuses / Q000473:pathology / Q000503:physiopathology / Q000601:surgery; D011183:Postoperative Complications / Q000188:drug therapy*; D011859:Radiography; D012220:Rhinitis / Q000000981:diagnostic imaging / Q000503:physiopathology / Q000628:therapy*; D055502:Secondary Prevention; D012852:Sinusitis / Q000000981:diagnostic imaging / Q000503:physiopathology / Q000628:therapy*; D013995:Time; D016896:Treatment Outcome
chemical_list: D000900:Anti-Bacterial Agents; D017291:Clarithromycin