title: Logopenic syndrome in posterior cortical atrophy.
abstract: Few language disorders have been reported in posterior cortical atrophy (PCA). Furthermore, no study has focused on screening for them and described these language deficits. The goal of this work was to describe linguistic examination of PCA patients and the impact of language disorders on neuropsychological performances compared to patients with other neurodegenerative syndromes and control groups. Linguistic examination of 9 PCA patients was carried out. The neuropsychological performance of the PCA group (16 patients) in the RAPID battery tests was compared with performances of patients with a logopenic variant of primary progressive aphasia (LPPA), patients with Alzheimer's disease and patients with amnestic mild cognitive impairment, as well as the control group. A "logopenic syndrome" with anomia, fluency impairment, and length-dependent deficit was found in 8/9 PCA patients. A comparison with other neurodegenerative syndromes showed that not only visual disorders but also language and verbal short-term memory disorders, such as those found in LPPA, can explain neuropsychological performances. A "logopenic syndrome" is frequently found in PCA and may be associated with poor performance on other verbally mediated neuropsychological tasks (e.g., verbal memory). Specific logopedic rehabilitation should be offered to these patients.
authors.affiliation: Department of Neurology, University Hospital of Besançon, 25030 Besancon, France. eloi.magnin@laposte.net
authors.forename: Eloi
authors.initials: E
authors.lastname: Magnin
authors.forename: Geraldine
authors.initials: G
authors.lastname: Sylvestre
authors.forename: Flora
authors.initials: F
authors.lastname: Lenoir
authors.forename: Elfried
authors.initials: E
authors.lastname: Dariel
authors.forename: Louise
authors.initials: L
authors.lastname: Bonnet
authors.forename: Gilles
authors.initials: G
authors.lastname: Chopard
authors.forename: Gregory
authors.initials: G
authors.lastname: Tio
authors.forename: Julie
authors.initials: J
authors.lastname: Hidalgo
authors.forename: Sabrina
authors.initials: S
authors.lastname: Ferreira
authors.forename: Catherine
authors.initials: C
authors.lastname: Mertz
authors.forename: Mikael
authors.initials: M
authors.lastname: Binetruy
authors.forename: Ludivine
authors.initials: L
authors.lastname: Chamard
authors.forename: Sophie
authors.initials: S
authors.lastname: Haffen
authors.forename: Ilham
authors.initials: I
authors.lastname: Ryff
authors.forename: Eric
authors.initials: E
authors.lastname: Laurent
authors.forename: Thierry
authors.initials: T
authors.lastname: Moulin
authors.forename: Pierre
authors.initials: P
authors.lastname: Vandel
authors.forename: Lucien
authors.initials: L
authors.lastname: Rumbach
mesh_terms: D000368:Aged; D000544:Alzheimer Disease / Q000150:complications; D018888:Aphasia, Primary Progressive / Q000150:complications; D001284:Atrophy / Q000150:complications; D001927:Brain Diseases / Q000150:complications* / Q000473:pathology; D002540:Cerebral Cortex / Q000473:pathology*; D016009:Chi-Square Distribution; D060825:Cognitive Dysfunction / Q000150:complications; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests; D012189:Retrospective Studies; D013064:Speech Disorders / Q000175:diagnosis / Q000209:etiology*; D018709:Statistics, Nonparametric