title: Monascusazaphilones A-C, three new azaphilone analogues isolated from the fungus Monascus purpureus BCRC 38108.
abstract: Investigation of the 95% EtOH extract of red yeast rice fermented with the pink mutant of the fungus Monascus purpureus BCRC 38108 led to the isolation of three new azaphilone derivatives, namely monascusazaphilones A-C (1-3), together with two known compounds. Compounds 1-3 were isolated from this species for the first time. Their structures were elucidated by 1-D and 2-D nuclear magnetic resonance spectroscopy together with HR-ESI-MS analysis and comparison of the spectroscopic data with those reported in the literatures. All isolates were evaluated for their inhibitory effects on nitric oxide (NO) production by macrophages. Among the isolates, compound 1 demonstrated stronger inhibition on NO production.
authors.affiliation: Bioresource Collection and Research Center, Food Industry Research and Development Institute, Hsinchu 300, Taiwan, ROC. wmd@firdi.org.tw
authors.forename: Ming-Der
authors.initials: MD
authors.lastname: Wu
authors.forename: Ming-Jen
authors.initials: MJ
authors.lastname: Cheng
authors.forename: Yi-Jen
authors.initials: YJ
authors.lastname: Yech
authors.forename: Yen-Lin
authors.initials: YL
authors.lastname: Chen
authors.forename: Kai-Ping
authors.initials: KP
authors.lastname: Chen
authors.forename: Ping-Hsun
authors.initials: PH
authors.lastname: Yang
authors.forename: Ih-Sheng
authors.initials: IS
authors.lastname: Chen
authors.forename: Gwo-Fang
authors.initials: GF
authors.lastname: Yuan
mesh_terms: D001578:Benzopyrans / Q000737:chemistry*; D032741:Monascus / Q000737:chemistry*; D010860:Pigments, Biological / Q000737:chemistry*
chemical_list: D001578:Benzopyrans; D010860:Pigments, Biological; C494154:azaphilone; C586008:monascusazaphilone A; C586009:monascusazaphilone B; C586010:monascusazaphilone C