title: Amyotrophic lateral sclerosis treatment with ultramicronized palmitoylethanolamide: a case report.
abstract: Amyotrophic lateral sclerosis is a fatal neurodegenerative disease characterized by progressive degeneration of motor neurons which leads to muscular atrophy, paralysis and death in 3-5 years from starting symptoms. This disorder is accompanied by noteworthy spinal inflammation mediated in particular by microglia and mast cells. No effective therapy is available. This report describes the effects of administering the anti-inflammatory agent palmitoylethanolamide in a case of sporadic amyotrophic lateral sclerosis. Palmitoylethanolamide treatment led to an improved clinical picture, as evidenced by electromyographic analysis and pulmonary function. Conceivably, the action of palmitoylethanolamide could result, in part, from its ability to dampen mast cell and microglia activation.
authors.affiliation: Macomer Rehabilitation Center, Nuoro Health Care Center, Via Salvemini 6, Sassari, Italy. simonettaclemente@gmail.com
authors.forename: Simonetta
authors.initials: S
authors.lastname: Clemente
mesh_terms: D000286:Administration, Sublingual; D000577:Amides; D000690:Amyotrophic Lateral Sclerosis / Q000178:diet therapy*; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage / Q000737:chemistry / Q000627:therapeutic use*; D019587:Dietary Supplements; D063388:Endocannabinoids / Q000008:administration & dosage / Q000737:chemistry / Q000627:therapeutic use*; D004983:Ethanolamines / Q000008:administration & dosage / Q000737:chemistry / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010169:Palmitic Acids / Q000008:administration & dosage / Q000737:chemistry / Q000627:therapeutic use*; D016896:Treatment Outcome
chemical_list: D000577:Amides; D000894:Anti-Inflammatory Agents, Non-Steroidal; D063388:Endocannabinoids; D004983:Ethanolamines; D010169:Palmitic Acids; C005958:palmidrol