title: Behavioral and neurochemical profile of some novel phenacyl based isonipecotamide derivatives.
abstract: Study of natural products led to the development of new molecules of potential biological activity. Piperidine nucleus constitutes one of the components of various alkaloids and drugs. During the course of our project regarding the synthesis of derivatives of piperidine carboxamide to study the effects of these compounds as anti-depressive agents, some of the compounds exhibited significant effects at all three doses, through open field activity thus establishing a direct relationship between dose and locomotion. Moreover, these compounds have also shown the decreased level of 5-HT alone with increased level of dopamine as an indication of their antagonism towards 5-HT receptor.
authors.affiliation: Department of Pharmaceutical Chemistry, University of Karachi, Karachi, Pakistan. dr_shamimakhtar58@yahoo.com
authors.forename: Shamim
authors.initials: S
authors.lastname: Akhtar
authors.forename: Muhammad
authors.initials: M
authors.lastname: Arif
authors.forename: Nousheen
authors.initials: N
authors.lastname: Mushtaq
authors.forename: Zafar Saeed
authors.initials: ZS
authors.lastname: Saify
authors.forename: Ahsaan
authors.initials: A
authors.lastname: Ahmed
authors.forename: Darakhshan Jabeen
authors.initials: DJ
authors.lastname: Haleem
authors.forename: Arfa
authors.initials: A
authors.lastname: Akram
mesh_terms: D015102:3,4-Dihydroxyphenylacetic Acid / Q000378:metabolism; D000577:Amides / Q000138:chemical synthesis / Q000494:pharmacology*; D000818:Animals; D000928:Antidepressive Agents / Q000138:chemical synthesis / Q000494:pharmacology*; D001522:Behavior, Animal / Q000187:drug effects*; D001921:Brain / Q000187:drug effects / Q000378:metabolism; D004298:Dopamine / Q000378:metabolism; D004305:Dose-Response Relationship, Drug; D006719:Homovanillic Acid / Q000378:metabolism; D006897:Hydroxyindoleacetic Acid / Q000378:metabolism; D008297:Male; D015394:Molecular Structure; D009043:Motor Activity / Q000187:drug effects*; D010880:Piperidines / Q000138:chemical synthesis / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D012701:Serotonin / Q000378:metabolism; D012702:Serotonin Antagonists / Q000138:chemical synthesis / Q000494:pharmacology*; D013329:Structure-Activity Relationship
chemical_list: D000577:Amides; D000928:Antidepressive Agents; D010880:Piperidines; D012702:Serotonin Antagonists; D015102:3,4-Dihydroxyphenylacetic Acid; D012701:Serotonin; D006897:Hydroxyindoleacetic Acid; D004298:Dopamine; D006719:Homovanillic Acid