title: Current treatment of acute myeloid leukemia.
abstract: OBJECTIVE
  The objectives of this review are to discuss standard and investigational nontransplant treatment strategies for acute myeloid leukemia (AML), excluding acute promyelocytic leukemia.
  
  
  RESULTS
  Most adults with AML die from their disease. The standard treatment paradigm for AML is remission induction chemotherapy with an anthracycline/cytarabine combination, followed by either consolidation chemotherapy or allogeneic stem cell transplantation, depending on the patient's ability to tolerate intensive treatment and the likelihood of cure with chemotherapy alone. Although this approach has changed little in the last three decades, increased understanding of the pathogenesis of AML and improvements in molecular genomic technologies are leading to novel drug targets and the development of personalized, risk-adapted treatment strategies. Recent findings related to prognostically relevant and potentially 'druggable' molecular targets are reviewed.
  
  
  CONCLUSIONS
  At the present time, AML remains a devastating and mostly incurable disease, but the combination of optimized chemotherapeutics and molecularly targeted agents holds significant promise for the future.
authors.affiliation: Leukemia Program, Weill Medical College of Cornell University, The New York Presbyterian Hospital, New York, New York 10065, USA. gar2001@med.cornell.edu
authors.forename: Gail J
authors.initials: GJ
authors.lastname: Roboz
mesh_terms: D018943:Anthracyclines / Q000008:administration & dosage; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D001374:Azacitidine / Q000008:administration & dosage / Q000031:analogs & derivatives; D060830:Consolidation Chemotherapy; D003561:Cytarabine / Q000008:administration & dosage; D000077209:Decitabine; D006801:Humans; D060828:Induction Chemotherapy; D015470:Leukemia, Myeloid, Acute / Q000188:drug therapy* / Q000235:genetics; D058990:Molecular Targeted Therapy; D057285:Precision Medicine; D033581:Stem Cell Transplantation
chemical_list: D018943:Anthracyclines; D003561:Cytarabine; D000077209:Decitabine; D001374:Azacitidine