title: Possible role of interleukin-17 in a prime/challenge model of multiple sclerosis.
abstract: No one single pathogen has been identified as the causative agent of multiple sclerosis (MS). Alternately, the likelihood of an autoimmune event may be nonspecifically enhanced by different infectious agents. In a novel animal model of MS, SJL/J mice primed through infection with a recombinant vaccinia virus (VV) encoding myelin proteolipid protein (PLP) (VV(PLP)) were susceptible to a central nervous system (CNS) inflammatory disease following administration of a nonspecific immunostimulant [complete Freund's adjuvant (CFA) plus Bordetella pertussis (BP)]. Mononuclear cells isolated from the brains, but not the spleens, of VV(PLP)-primed CFA/BP challenged mice produced interleukin (IL)-17 and interferon-γ and transferred a CNS inflammatory disease to naïve SJL/J mice. Administration of curdlan, a T helper 17 cell inducer, unexpectedly resulted in less severe clinical and histological signs of disease, compared to CFA/BP challenged mice, despite the induction of IL-17 in the periphery. Further examination of the VV(PLP)-prime CFA/BP challenge model may suggest new mechanisms for how different pathogens associated with MS can protect or enhance disease.
authors.affiliation: Department of Pathology, University of Utah School of Medicine, Salt Lake City, UT 84132, USA.
authors.forename: Jane E
authors.initials: JE
authors.lastname: Libbey
authors.forename: Ikuo
authors.initials: I
authors.lastname: Tsunoda
authors.forename: Robert S
authors.initials: RS
authors.lastname: Fujinami
mesh_terms: D000276:Adjuvants, Immunologic / Q000008:administration & dosage; D000818:Animals; D001921:Brain / Q000276:immunology* / Q000378:metabolism / Q000473:pathology; D004195:Disease Models, Animal; D005260:Female; D005822:Genetic Vectors; D056747:Immunomodulation; D007371:Interferon-gamma / Q000096:biosynthesis / Q000276:immunology; D020381:Interleukin-17 / Q000096:biosynthesis / Q000276:immunology*; D007963:Leukocytes, Mononuclear / Q000276:immunology* / Q000378:metabolism / Q000473:pathology / Q000637:transplantation; D051379:Mice; D009103:Multiple Sclerosis / Q000276:immunology* / Q000378:metabolism / Q000473:pathology; D018991:Myelin Proteolipid Protein / Q000235:genetics / Q000276:immunology; D009928:Organ Specificity; D011135:Polysaccharides, Bacterial / Q000008:administration & dosage; D051381:Rats; D011994:Recombinant Proteins / Q000235:genetics / Q000276:immunology; D012720:Severity of Illness Index; D013154:Spleen / Q000276:immunology / Q000378:metabolism / Q000473:pathology; D014616:Vaccinia virus / Q000235:genetics; D047071:beta-Glucans / Q000008:administration & dosage
chemical_list: D000276:Adjuvants, Immunologic; D020381:Interleukin-17; D018991:Myelin Proteolipid Protein; D011135:Polysaccharides, Bacterial; D011994:Recombinant Proteins; D047071:beta-Glucans; C038459:curdlan; D007371:Interferon-gamma