title: A skincare containing retinol adenosine and hyaluronic acid optimises the benefits from a type A botulinum toxin injection.
abstract: BACKGROUND
  A monocentre double-blind two parallel group clinical study was conducted to assess whether a new skincare regimen containing retinol, adenosine and hyaluronic acid, applied after the injection of botulinum toxin A to the glabellar area, provided a beneficial effect.
  
  
  METHODS
  Standardised photographs acquired using LifeViz cameras and zoomed pictures of the glabella and of the crow's feet areas were analysed with automatic well-defined procedures. Perceived efficacy and tolerance were also analysed by comparison between the two groups.
  
  
  RESULTS
  A beneficial effect versus placebo-treated group was proven in the group having topically applied the new skincare regimen for 2 months following botulinum toxin A injection with no touch up after 1 month. 3D image analysis showed more rapid results on D10 and enhanced efficacy on M2. Moreover, a beneficial effect independent of injection was measured in the crow's feet area, and analysis of the self-evaluation questionnaire showed enhanced efficacy perceived by the volunteers.
  
  
  CONCLUSIONS
  A specially developed skincare regimen applied immediately after botulinum toxin A injection completes the beneficial effect of the injection on the glabellar area and offers clinical benefits in fine lines, wrinkles and smoothness on the whole face.
authors.affiliation: Clinique Iena, Paris, France. benjaminascher@wanadoo.fr
authors.forename: Benjamin
authors.initials: B
authors.lastname: Ascher
authors.forename: Chantal
authors.initials: C
authors.lastname: Fanchon
authors.forename: Leila
authors.initials: L
authors.lastname: Kanoun-Copy
authors.forename: Anne
authors.initials: A
authors.lastname: Bouloc
authors.forename: Florence
authors.initials: F
authors.lastname: Benech
mesh_terms: D000241:Adenosine / Q000008:administration & dosage / Q000627:therapeutic use*; D000279:Administration, Cutaneous; D000328:Adult; D019274:Botulinum Toxins, Type A / Q000008:administration & dosage / Q000627:therapeutic use*; D004311:Double-Blind Method; D004359:Drug Therapy, Combination; D005145:Face; D005260:Female; D006801:Humans; D006820:Hyaluronic Acid / Q000008:administration & dosage / Q000627:therapeutic use*; D021621:Imaging, Three-Dimensional; D008875:Middle Aged; D014801:Vitamin A / Q000008:administration & dosage / Q000627:therapeutic use*
chemical_list: D014801:Vitamin A; D006820:Hyaluronic Acid; D019274:Botulinum Toxins, Type A; D000241:Adenosine