title: Cord blood C-peptide levels relate to the metabolic profile of women with and without gestational diabetes.
abstract: Plasma C-peptide reflects the insulin-secretory activity of pancreatic β-cells which modulates fetal growth. Cord blood C-peptide levels were measured in women with gestational diabetes mellitus (GDM) and in women with normal glucose tolerance (NGT). Forty-one women underwent a 75-g oral glucose tolerance test (18 GDM, 23 NGT). Cord blood C-peptide (p = 0.09) and glucose levels (p = 0.08) from newborns of GDM women tended to be higher than those from NGT women. In the entire group, cord blood C-peptide correlated with maternal insulin, fasting C-peptide, insulin sensitivity, interleukin-6, weight and body mass index measured at screening (ρ from 0.34 to 0.48, all p < 0.05) and tended to correlate with offspring weight (ρ = 0.28, p = 0.08). Newborns of GDM women tended to have elevated cord blood C-peptide which correlated with maternal insulin, insulin sensitivity and anthropometric measures at diagnosis and with offspring characteristics. This suggests that insulin-secretory activity of the newborn is related to maternal metabolic parameters.
authors.affiliation: Endocrinology and Genomics, Laval University Medical Research Center, Laval University, Quebec, Canada.
authors.forename: Marie-Christine
authors.initials: MC
authors.lastname: Dubé
authors.forename: Anne-Sophie
authors.initials: AS
authors.lastname: Morisset
authors.forename: André
authors.initials: A
authors.lastname: Tchernof
authors.forename: S John
authors.initials: SJ
authors.lastname: Weisnagel
mesh_terms: D000328:Adult; D015992:Body Mass Index; D002096:C-Peptide / Q000097:blood*; D016640:Diabetes, Gestational / Q000097:blood*; D005260:Female; D005312:Fetal Blood / Q000378:metabolism*; D005951:Glucose Tolerance Test; D006801:Humans; D007333:Insulin Resistance; D015850:Interleukin-6 / Q000097:blood; D055442:Metabolome; D011247:Pregnancy; D011256:Pregnancy Outcome; D011792:Quebec; D012044:Regression Analysis
chemical_list: D002096:C-Peptide; D015850:Interleukin-6