title: Intracerebral delivery of carboplatin in combination with either 6 MV photons or monoenergetic synchrotron X-rays are equally efficacious for treatment of the F98 rat glioma.
abstract: BACKGROUND
  The purpose of the present study was to compare side-by-side the therapeutic efficacy of a 6-day infusion of carboplatin, followed by X-irradiation with either 6 MV photons or synchrotron X-rays, tuned above the K-edge of Pt, for treatment of F98 glioma bearing rats.
  
  
  METHODS
  Carboplatin was administered intracerebrally (i.c.) to F98 glioma bearing rats over 6 days using AlzetTM osmotic pumps starting 7 days after tumor implantation. Radiotherapy was delivered in a single 15 Gy fraction on day 14 using a conventional 6 MV linear accelerator (LINAC) or 78.8 keV synchrotron X-rays.
  
  
  RESULTS
  Untreated control animals had a median survival time (MeST) of 33 days. Animals that received either carboplatin alone or irradiation alone with either 78.8 keV or 6 MV had a MeSTs 38 and 33 days, respectively. Animals that received carboplatin in combination with X-irradiation had a MeST of > 180 days with a 55% cure rate, irrespective of whether they were irradiated with either 78.8 KeV synchrotron X-rays or 6MV photons.
  
  
  CONCLUSIONS
  These studies have conclusively demonstrated the equivalency of i.c. delivery of carboplatin in combination with X-irradiation with either 6 MV photons or synchrotron X-rays.
authors.affiliation: INSERM U836 Équipe 6, Grenoble Institut des Neurosciences, Grenoble, France.
authors.forename: Laure
authors.initials: L
authors.lastname: Bobyk
authors.forename: Magali
authors.initials: M
authors.lastname: Edouard
authors.forename: Pierre
authors.initials: P
authors.lastname: Deman
authors.forename: Julia
authors.initials: J
authors.lastname: Rousseau
authors.forename: Jean-François
authors.initials: JF
authors.lastname: Adam
authors.forename: Jean-Luc
authors.initials: JL
authors.lastname: Ravanat
authors.forename: François
authors.initials: F
authors.lastname: Estève
authors.forename: Jacques
authors.initials: J
authors.lastname: Balosso
authors.forename: Rolf F
authors.initials: RF
authors.lastname: Barth
authors.forename: Hélène
authors.initials: H
authors.lastname: Elleaume
mesh_terms: D000818:Animals; D001932:Brain Neoplasms / Q000188:drug therapy / Q000473:pathology / Q000532:radiotherapy; D016190:Carboplatin / Q000008:administration & dosage*; D003131:Combined Modality Therapy; D005910:Glioma / Q000188:drug therapy / Q000473:pathology / Q000532:radiotherapy; D053208:Kaplan-Meier Estimate; D008297:Male; D009374:Neoplasms, Experimental / Q000188:drug therapy / Q000473:pathology / Q000532:radiotherapy; D017785:Photons; D051381:Rats; D017356:Synchrotrons; D014964:X-Ray Therapy
chemical_list: D016190:Carboplatin