title: Kinetic resolution of propargylamines via a highly enantioselective non-enzymatic N-acylation process.
abstract: The non-enzymatic kinetic resolution of diversely substituted primary propargylic amines is reported featuring a highly selective acetyl transfer using (1S,2S)- in conjunction with Aliquat(TM) 336, affording the corresponding enantio-enriched N-acetylated propargylic amines with unprecedented levels of selectivity (s-factors of up to 193 at 50% conversion).
authors.affiliation: Laboratoire de Chimie Organique, ESPCI ParisTech, CNRS, 10 rue Vauquelin, 75231 Paris Cedex 05, France.
authors.forename: Amandine
authors.initials: A
authors.lastname: Kolleth
authors.forename: Sarah
authors.initials: S
authors.lastname: Christoph
authors.forename: Stellios
authors.initials: S
authors.lastname: Arseniyadis
authors.forename: Janine
authors.initials: J
authors.lastname: Cossy
mesh_terms: D000215:Acylation; D007700:Kinetics; D010293:Pargyline / Q000031:analogs & derivatives* / Q000737:chemistry; D011437:Propylamines / Q000737:chemistry*; D012997:Solvents / Q000737:chemistry; D013237:Stereoisomerism; D013696:Temperature
chemical_list: D011437:Propylamines; D012997:Solvents; C009054:propargylamine; D010293:Pargyline