title: Stubborn Tregs limit T-cell therapy.
abstract: In this issue of Blood, Baba and colleagues characterize a residual pool ofCD4+CD25+Foxp3+ regulatory T cells (Tregs) surviving a nonmyeloablative conditioning regimen that undergo robust homeostatic expansion to limit the full potential of adoptive T-cell therapy (ACT) for the treatment of cancer.
authors.affiliation: National Cancer Institute.
authors.forename: Christopher A
authors.initials: CA
authors.lastname: Klebanoff
authors.forename: Luca
authors.initials: L
authors.lastname: Gattinoni
mesh_terms: D000818:Animals; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology*; D008212:Lymphocyte Depletion; D008231:Lymphopenia / Q000276:immunology* / Q000628:therapy*; D011833:Radiation Injuries, Experimental / Q000517:prevention & control*; D050378:T-Lymphocytes, Regulatory / Q000276:immunology*