title: Genomic and phylogenetic characterization of Brazilian yellow fever virus strains.
abstract: Globally, yellow fever virus infects nearly 200,000 people, leading to 30,000 deaths annually. Although the virus is endemic to Latin America, only a single genome from this region has been sequenced. Here, we report 12 Brazilian yellow fever virus complete genomes, their genetic traits, phylogenetic characterization, and phylogeographic dynamics. Variable 3' noncoding region (3'NCR) patterns and specific mutations throughout the open reading frame altered predicted secondary structures. Our findings suggest that whereas the introduction of yellow fever virus in Brazil led to genotype I-predominant dispersal throughout South and Central Americas, genotype II remained confined to Bolivia, Peru, and the western Brazilian Amazon.
authors.affiliation: Center for Technological Innovation, Instituto Evandro Chagas, Ananindeua, Brazil.
authors.forename: Marcio R T
authors.initials: MR
authors.lastname: Nunes
authors.forename: Gustavo
authors.initials: G
authors.lastname: Palacios
authors.forename: Jedson F
authors.initials: JF
authors.lastname: Cardoso
authors.forename: Livia C
authors.initials: LC
authors.lastname: Martins
authors.forename: Edivaldo C
authors.initials: EC
authors.lastname: Sousa
authors.forename: Clayton P S
authors.initials: CP
authors.lastname: de Lima
authors.forename: Daniele B A
authors.initials: DB
authors.lastname: Medeiros
authors.forename: Nazir
authors.initials: N
authors.lastname: Savji
authors.forename: Aaloki
authors.initials: A
authors.lastname: Desai
authors.forename: Sueli G
authors.initials: SG
authors.lastname: Rodrigues
authors.forename: Valeria L
authors.initials: VL
authors.lastname: Carvalho
authors.forename: W Ian
authors.initials: WI
authors.lastname: Lipkin
authors.forename: Pedro F C
authors.initials: PF
authors.lastname: Vasconcelos
mesh_terms: D001483:Base Sequence; D001938:Brazil; D017931:DNA Primers; D016679:Genome, Viral; D006031:Glycosylation; D010802:Phylogeny; D016133:Polymerase Chain Reaction; D015005:Yellow fever virus / Q000145:classification / Q000235:genetics*
chemical_list: D017931:DNA Primers