title: A rhodamine-deoxylactam based sensor for chromo-fluorogenic detection of nerve agent simulant.
abstract: N-(rhodamine B)-deoxylactam-5-amino-1-pentanol (dRB-APOH) was designed and prepared as the chromo-fluorogenic sensor for detection of a nerve agent simulant via analyte triggered tandem phosphorylation and opening of the intramolecular deoxylactam. The successful detection of diethyl chlorophosphate suggests the utility of rhodamine-deoxylactams as the chromo-fluorogenic signal reporting platform for design of sensors targeting reactive chemical species via various chemistries.
authors.affiliation: Department of Chemical Biology, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen, China.
authors.forename: Zhisheng
authors.initials: Z
authors.lastname: Wu
authors.forename: Xuanjun
authors.initials: X
authors.lastname: Wu
authors.forename: Yuhui
authors.initials: Y
authors.lastname: Yang
authors.forename: Ting-bin
authors.initials: TB
authors.lastname: Wen
authors.forename: Shoufa
authors.initials: S
authors.lastname: Han
mesh_terms: D002619:Chemical Warfare Agents / Q000032:analysis*; D003124:Colorimetry / Q000379:methods; D004396:Coloring Agents / Q000737:chemistry; D005456:Fluorescent Dyes / Q000737:chemistry*; D007769:Lactams / Q000737:chemistry; D009943:Organophosphorus Compounds / Q000032:analysis*; D000439:Pentanols / Q000737:chemistry*; D010766:Phosphorylation; D012235:Rhodamines / Q000737:chemistry*; D012680:Sensitivity and Specificity; D013050:Spectrometry, Fluorescence / Q000379:methods
chemical_list: D002619:Chemical Warfare Agents; D004396:Coloring Agents; D005456:Fluorescent Dyes; D007769:Lactams; D009943:Organophosphorus Compounds; D000439:Pentanols; D012235:Rhodamines; C548970:diethylchlorophosphate; C029773:rhodamine B; C024999:n-pentanol