title: Report: Platelet aggregation inhibition activity of selected legumes of Pakistan.
abstract: The current study was designed to explore the platelet aggregation activity of methanolic extracts of green gram, lentil, mash bean and soya bean. The extracts dose-dependently inhibited platelet aggregation initiated by arachidonic acid (AA) and platelet activating factor (PAF). Extract of green gram was effective only against AA mediated activity while mash bean and soya bean extracts were effective against both AA and PAF mediated activity. But lentil extract has no activity. The order of activity based on IC(50) value is, Mash bean > Soya bean > Green gram. This preliminary result suggests that legume seed extract may be taken as a candidate lead natural compound to be considered in the search for natural products with beneficial effects on aberrant platelet activation mediated cardiovascular disorders.
authors.affiliation: Department of Pharmacognosy, University of Karachi, Karachi, Pakistan. ahirzia@gmail.com
authors.forename: Muhammad
authors.initials: M
authors.lastname: Zia-Ul-Haq
authors.forename: Sagheer
authors.initials: S
authors.lastname: Ahmed
authors.forename: Ghazala Hafeez
authors.initials: GH
authors.lastname: Rizwani
authors.forename: Mughal
authors.initials: M
authors.lastname: Qayum
authors.forename: Shakeel
authors.initials: S
authors.lastname: Ahmad
authors.forename: Muhammad
authors.initials: M
authors.lastname: Hanif
mesh_terms: D016718:Arachidonic Acid; D004305:Dose-Response Relationship, Drug; D007887:Fabaceae / Q000737:chemistry; D006801:Humans; D027806:Lens Plant; D000432:Methanol / Q000737:chemistry; D010154:Pakistan; D010936:Plant Extracts / Q000302:isolation & purification / Q000494:pharmacology*; D010946:Plants, Medicinal; D010972:Platelet Activating Factor; D010974:Platelet Aggregation / Q000187:drug effects*; D010975:Platelet Aggregation Inhibitors / Q000302:isolation & purification / Q000494:pharmacology*; D010979:Platelet Function Tests; D012639:Seeds; D012997:Solvents / Q000737:chemistry; D013025:Glycine max
chemical_list: D010936:Plant Extracts; D010972:Platelet Activating Factor; D010975:Platelet Aggregation Inhibitors; D012997:Solvents; D016718:Arachidonic Acid; D000432:Methanol