title: Gender- and age-related differences in clinical presentation and management of outpatients with stable coronary artery disease.
abstract: BACKGROUND
  Contemporary generalizable data on the demographics and management of outpatients with stable coronary artery disease (CAD) in routine clinical practice are sparse. Using the data from the CLARIFY registry we describe gender- and age-related differences in baseline characteristics and management of these patients across broad geographic regions.
  
  
  METHODS
  This international, prospective, observational, longitudinal registry enrolled stable CAD outpatients from 45 countries in Africa, Asia, Australia, Europe, the Middle East, and North, Central, and South America.
  
  
  RESULTS
  Baseline data were available for 33280 patients. Mean (SD) age was 64 (10.5) years and 22.5% of patients were female. The prevalence of CAD risk factors was generally higher in women than in men. Women were older (66.6 vs 63.4 years), more frequently diagnosed with diabetes (33% vs 28%), hypertension (79% vs 69%), and higher resting heart rate (69 vs 67 bpm), and were less physically active. Smoking and a history of myocardial infarction were more common in men. Women were more likely to have angina (28% vs 20%), but less likely to have undergone revascularization procedures. CAD was more likely to be asymptomatic in older patients perhaps because of reduced levels of physical activity. Prescription of evidence-based medication for secondary prevention varied with age, with patients ≥ 75 years treated less often with beta blockers, aspirin and angiotensin-converting enzyme inhibitors than patients <65 years.
  
  
  CONCLUSIONS
  Important gender-related differences in clinical characteristics and management continue to exist in all age groups of outpatients with stable CAD.
authors.affiliation: Department of Cardiology and LTTA Centre, University of Ferrara, Salvatore Maugeri Foundation, IRCCS, Lumezzan, Italy. fri@unife.it
authors.forename: Roberto
authors.initials: R
authors.lastname: Ferrari
authors.forename: Hélène
authors.initials: H
authors.lastname: Abergel
authors.forename: Ian
authors.initials: I
authors.lastname: Ford
authors.forename: Kim M
authors.initials: KM
authors.lastname: Fox
authors.forename: Nicola
authors.initials: N
authors.lastname: Greenlaw
authors.forename: Ph Gabriel
authors.initials: PG
authors.lastname: Steg
authors.forename: Dayi
authors.initials: D
authors.lastname: Hu
authors.forename: Michal
authors.initials: M
authors.lastname: Tendera
authors.forename: Jean-Claude
authors.initials: JC
authors.lastname: Tardif
mesh_terms: D000367:Age Factors; D000368:Aged; D000553:Ambulatory Care / Q000379:methods / Q000639:trends*; D003324:Coronary Artery Disease / Q000175:diagnosis* / Q000453:epidemiology / Q000628:therapy*; D019468:Disease Management; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D038622:Internationality; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D010045:Outpatients; D011446:Prospective Studies; D012042:Registries; D012727:Sex Characteristics; D016896:Treatment Outcome