title: Static renal scintigraphy with 99mTc-DMSA for the assessment of renal damage after therapy for acute lymphoblastic leukemia in children.
abstract: BACKGROUND
  Acute lymphoblastic leukemia (ALL) and its treatment may adversely affect kidney function. The aim of the present study was to determine whether 99mTc-DMSA static renal scintigraphy can be used to disclose kidney damage at the end of therapy for ALL in children.
  
  
  METHODS
  The study group consisted of 48 ALL patients aged 6.6-22.9 years, with a mean time of continuous complete remission of 51 months. Static renal scintigraphy with 99mTc-DMSA was performed in all patients.
  
  
  RESULTS
  Minor scars in the renal cortex were diagnosed with scintigraphy in 6 (13%) patients. A significant correlation was found between renal scarring and a history of urinary tract infection.
  
  
  CONCLUSIONS
  No clinically significant kidney damage was found after completion of treatment of ALL. Static renal scintigraphy may be a valuable noninvasive method for visualization of renal cortex pathology.
authors.affiliation: Zakład Medycyny Nuklearnej Pomorskiego Uniwersytetu Medycznego w Szczecinie ul. Unii Lubelskiej 1, 71-252 Szczecin.
authors.forename: Maria H
authors.initials: MH
authors.lastname: Listewnik
authors.forename: Jarosław
authors.initials: J
authors.lastname: Peregud-Pogorzelski
authors.forename: Bozena
authors.initials: B
authors.lastname: Birkenfeld
authors.forename: Monika
authors.initials: M
authors.lastname: Matacz
authors.forename: Piotr
authors.initials: P
authors.lastname: Zorga
authors.forename: Elwira
authors.initials: E
authors.lastname: Szychot
authors.forename: Hanna
authors.initials: H
authors.lastname: Piwowarska-Bilska
authors.forename: Andrzej
authors.initials: A
authors.lastname: Brodkiewicz
mesh_terms: D000293:Adolescent; D000328:Adult; D002648:Child; D002921:Cicatrix / Q000000981:diagnostic imaging* / Q000209:etiology; D005260:Female; D006801:Humans; D007668:Kidney / Q000000981:diagnostic imaging; D007674:Kidney Diseases / Q000000981:diagnostic imaging* / Q000209:etiology; D008297:Male; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000150:complications* / Q000628:therapy*; D011877:Radionuclide Imaging; D012074:Remission Induction; D019783:Technetium Tc 99m Dimercaptosuccinic Acid; D014552:Urinary Tract Infections / Q000000981:diagnostic imaging* / Q000209:etiology; D055815:Young Adult
chemical_list: D019783:Technetium Tc 99m Dimercaptosuccinic Acid