title: Near infrared light triggered release of biomacromolecules from hydrogels loaded with upconversion nanoparticles.
abstract: Using a photosensitive hybrid hydrogel loaded with upconversion nanoparticles (UCNPs), we show that continuous-wave near-infrared (NIR) light (980 nm) can be used to induce the gel-sol transition and release large, inactive biomacromolecules (protein and enzyme) entrapped in the hydrogel into aqueous solution "on demand", where their bioactivity is recovered. This study is a new demonstration and development in harnessing the unique multiphoton effect of UCNPs for photosensitive materials of biomedical interest.
authors.affiliation: Département de Chimie, Université de Sherbrooke, Sherbrooke, Québec, Canada J1K 2R1.
authors.forename: Bin
authors.initials: B
authors.lastname: Yan
authors.forename: John-Christopher
authors.initials: JC
authors.lastname: Boyer
authors.forename: Damien
authors.initials: D
authors.lastname: Habault
authors.forename: Neil R
authors.initials: NR
authors.lastname: Branda
authors.forename: Yue
authors.initials: Y
authors.lastname: Zhao
mesh_terms: D000818:Animals; D002417:Cattle; D003692:Delayed-Action Preparations / Q000737:chemistry*; D016650:Fluorescein-5-isothiocyanate / Q000008:administration & dosage / Q000031:analogs & derivatives*; D020100:Hydrogels / Q000737:chemistry*; D007259:Infrared Rays; D008027:Light; D053758:Nanoparticles / Q000737:chemistry*; D044367:Phase Transition; D012710:Serum Albumin, Bovine / Q000008:administration & dosage*
chemical_list: D003692:Delayed-Action Preparations; D020100:Hydrogels; C039217:fluorescein isothiocyanate bovine serum albumin; D012710:Serum Albumin, Bovine; D016650:Fluorescein-5-isothiocyanate