title: S100B: role in cardiac remodeling and function following myocardial infarction in diabetes.
abstract: OBJECTIVE
  S100B plays a role in cardiac remodeling following myocardial infarction (MI) and in diabetic vascular complications but not examined in diabetic myocardium. We thus examined the effects of targeted deletion of S100B gene on post-MI hearts.
  
  
  METHODS
  Coronary artery ligation or sham was performed 15 weeks after streptozotocin (STZ) or vehicle injection in wild-type (WT) and S100B knock-out (BKO) mice. Left ventricular (LV) structural and functional remodeling was studied 35 days after induction of MI.
  
  
  RESULTS
  In diabetes, post-MI remodeling exhibited an attenuated increase in LV mass, dilation, and myocyte hypertrophy in association with increased apoptosis and fibrosis and reduced matrix metalloproteinase-2 (MMP-2) activity. Despite reduced LV dilation, impairment of cardiac function was similar to non-diabetic controls. Both diabetes and MI alone induced myocardial S100B and its canonical receptor for advanced glycation end product (RAGE) expression. By contrast, in post-MI diabetic myocardium, S100B expression was attenuated. Diabetic BKO, following MI demonstrated increased ventricular dilation compared to WT, in association with greater impairment of cardiac function, GLUT4 expression and systemic AGE levels.
  
  
  CONCLUSIONS
  These data suggest that S100B expression may serve to modulate cardiac metabolism and adverse consequences of AGE in diabetic post-MI remodeling and function.
authors.affiliation: Division of Cardiology, Department of Medicine, Keenan Research Centre, Li Ka Shing Knowledge Institute, St. Michael's Hospital, University of Toronto, Ontario, Canada.
authors.forename: Forough
authors.initials: F
authors.lastname: Mohammadzadeh
authors.forename: Jean-Francois
authors.initials: JF
authors.lastname: Desjardins
authors.forename: James N
authors.initials: JN
authors.lastname: Tsoporis
authors.forename: Gerald
authors.initials: G
authors.lastname: Proteau
authors.forename: Howard
authors.initials: H
authors.lastname: Leong-Poi
authors.forename: Thomas G
authors.initials: TG
authors.lastname: Parker
mesh_terms: D000818:Animals; D001786:Blood Glucose / Q000032:analysis; D003094:Collagen / Q000032:analysis; D004268:DNA-Binding Proteins / Q000235:genetics / Q000378:metabolism; D048909:Diabetes Complications; D003921:Diabetes Mellitus, Experimental / Q000473:pathology; D005786:Gene Expression Regulation; D008297:Male; D051379:Mice; D018345:Mice, Knockout; D009203:Myocardial Infarction / Q000401:mortality / Q000473:pathology*; D009414:Nerve Growth Factors / Q000235:genetics / Q000378:metabolism*; D064568:S100 Calcium Binding Protein beta Subunit; D009418:S100 Proteins / Q000235:genetics / Q000378:metabolism*; D014157:Transcription Factors / Q000235:genetics / Q000378:metabolism; D020257:Ventricular Remodeling / Q000235:genetics*
chemical_list: D001786:Blood Glucose; D004268:DNA-Binding Proteins; C528734:GLUT4 enhancer factor, mouse; D009414:Nerve Growth Factors; D064568:S100 Calcium Binding Protein beta Subunit; D009418:S100 Proteins; C579159:S100b protein, mouse; D014157:Transcription Factors; D003094:Collagen