title: p.R72P, PIN3 Ins16bp polymorphisms of TP53 and CCR5?32 in north Indian breast cancer patients.
abstract: BACKGROUND
  The present study aimed to find the prognostic implications of two polymorphisms in TP53 (p.R72P, PIN3 Ins16bp) and one in CCR5 (CCR5/32) in sporadic breast cancer patients.
  
  
  METHODS
  DNA samples of 80 breast cancer patients and 80 age and gender matched unrelated healthy control individuals from Punjab, North West India were analyzed.
  
  
  RESULTS
  For p.R72P, the genotype frequency was 13.8% (RR), 58.8% (RP), 27.5% (PP) in patients and 33.9% (RR), 40.0% (RP), 26.5% (PP) in controls. For PIN3 Ins16bp, the genotype frequencies were 53.75% (A1A1), 37.5% (A1A2), 8.75% (A2A2) in patients and 66.3% (A1A1), 31.3% (A1A2), 2.5% (A2A2) in controls. Only 4 (5%) breast cancer patients were heterozygous for CCR5Δ32 deletion. Common RR-A1A1-WT/WT genotype was lower while RP-A1A2-WT/WT genotype was higher in patients as compared to controls. RP-A1A1-WT/WT genotype was significantly higher in patients as compared to control individuals (p = 0.008).
  
  
  CONCLUSIONS
  Though a clear association of any particular genotype with sporadic breast cancer or stage was not apparent, the results of present study were suggestive that sporadic breast cancer patients with RR-A1A1-WT/WT genotype might have a better response to chemotherapy, thus improving their chances of survival.
authors.affiliation: Human Cytogenetics Laboratory, Department of Human Genetics, Guru Nanak Dev University, Punjab, India.
authors.forename: Kamlesh
authors.initials: K
authors.lastname: Guleria
authors.forename: Sarika
authors.initials: S
authors.lastname: Sharma
authors.forename: Mridu
authors.initials: M
authors.lastname: Manjari
authors.forename: Manjit Singh
authors.initials: MS
authors.lastname: Uppal
authors.forename: Neeti Rajan
authors.initials: NR
authors.lastname: Singh
authors.forename: Vasudha
authors.initials: V
authors.lastname: Sambyal
mesh_terms: D000328:Adult; D000368:Aged; D000483:Alleles; D044466:Asian People; D001943:Breast Neoplasms / Q000235:genetics* / Q000473:pathology; D016022:Case-Control Studies; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006579:Heterozygote; D006801:Humans; D007194:India; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic; D011379:Prognosis; D019713:Receptors, CCR5 / Q000235:genetics*; D016159:Tumor Suppressor Protein p53 / Q000235:genetics*
chemical_list: D019713:Receptors, CCR5; C495901:TP53 protein, human; D016159:Tumor Suppressor Protein p53