title: [Peripheral mechanisms of action of oxatriazolium-5-olate derivative 3-(3-[1,2,4]-triazolo)oxatriazolium-5-olate in spontaneously hypertensive rats].
abstract: It is shown that 3-(3-[1,2,4]-triazolo)-oxatriazolium-5-olate (azasidnon-6) can act directly on the vascular wall of isolated segments of caudal ventral artery of SHR rats. Using heme-dependent soluble guanyl cyclase inhibitor 1H-[1,2,4]-oxadiazolo[4,3-a]quinoxalin-1-one (ODQ), it has been found that one of the possible mechanisms of azasidnon-6 vasodilatory action includes heme-dependent activation of a soluble form of guanylate cyclase.
authors.forename: M M
authors.initials: MM
authors.lastname: Artem'eva
authors.forename: A B
authors.initials: AB
authors.lastname: Postnikov
authors.forename: O V
authors.initials: OV
authors.lastname: Akinfieva
authors.forename: I L
authors.initials: IL
authors.lastname: Daliger
authors.forename: S A
authors.initials: SA
authors.lastname: Shevelev
authors.forename: O S
authors.initials: OS
authors.lastname: Medvedev
authors.forename: N A
authors.initials: NA
authors.lastname: Medvedeva
mesh_terms: D000818:Animals; D001158:Arteries / Q000187:drug effects*; D006162:Guanylate Cyclase / Q000037:antagonists & inhibitors / Q000378:metabolism; D006418:Heme / Q000378:metabolism; D008297:Male; D009569:Nitric Oxide / Q000378:metabolism; D009599:Nitroprusside / Q000494:pharmacology; D010069:Oxadiazoles / Q000494:pharmacology; D010656:Phenylephrine / Q000494:pharmacology; D011810:Quinoxalines / Q000494:pharmacology; D051381:Rats; D011918:Rats, Inbred SHR; D017208:Rats, Wistar; D013623:Tail / Q000098:blood supply; D046509:Tissue Culture Techniques; D014230:Triazoles / Q000494:pharmacology*; D014662:Vasoconstrictor Agents / Q000494:pharmacology; D014664:Vasodilation / Q000187:drug effects*; D014665:Vasodilator Agents / Q000494:pharmacology*
chemical_list: C494582:1H-(1,2,3)oxadiazolo(4,4-a)quinoxalin-1-one; C576651:3-(3-(1,2,4)-triazolo)-oxatriazolium-5-olate; D010069:Oxadiazoles; D011810:Quinoxalines; D014230:Triazoles; D014662:Vasoconstrictor Agents; D014665:Vasodilator Agents; D009599:Nitroprusside; D010656:Phenylephrine; D009569:Nitric Oxide; D006418:Heme; D006162:Guanylate Cyclase