title: Protective effect of Hypericum hircinum on doxorubicin-induced cardiotoxicity in rats.
abstract: Oxidative stress is the main factor in doxorubicin (DOX) induced cardiotoxicity. Wistar rats received either DOX (3 mg kg⁻¹, i.p.) every other day or combination of Hypericum hircinum (100 and 200 mg kg⁻¹, p.o.) and DOX or H. hircinum (200 mg kg⁻¹, p.o.) extract alone for 2 weeks. Cardiotoxicity was assessed by recording changes in ECG, heart rate and measuring the levels of cardiac marker enzymes--lactic acid dehydrogenase, creatine phosphokinase, glutamic oxaloacetic transaminase, the antioxidant defence enzymes--reduced glutathione (GSH), superoxide dismutase (SOD) and lipid peroxidative value (LPO) at the end of treatment schedule. Treatment with H. hircinum significantly (p < 0.05) decreased the levels of LPO and marker enzymes, increased the levels of GSH and SOD, reversed the changes in ECG and prevented the decrease in heart weight in DOX-treated group. The results suggest that H. hircinum has the potential to prevent the cardiotoxic effects induced by DOX.
authors.affiliation: a Department of Pharmacology , M.G.V's Pharmacy College , Panchavati, Nasik , Maharashtra 422003 , India.
authors.forename: Sudeep
authors.initials: S
authors.lastname: Shah
authors.forename: Mahalaxmi
authors.initials: M
authors.lastname: Mohan
authors.forename: Sanjay
authors.initials: S
authors.lastname: Kasture
authors.forename: Mauro
authors.initials: M
authors.lastname: Ballero
authors.forename: Andrea
authors.initials: A
authors.lastname: Maxia
authors.forename: Cinzia
authors.initials: C
authors.lastname: Sanna
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000378:metabolism; D004317:Doxorubicin / Q000633:toxicity*; D004562:Electrocardiography; D005978:Glutathione / Q000378:metabolism; D006321:Heart / Q000187:drug effects; D020902:Hypericum / Q000737:chemistry*; D008315:Malondialdehyde / Q000378:metabolism; D018384:Oxidative Stress / Q000187:drug effects; D051381:Rats; D017208:Rats, Wistar; D013482:Superoxide Dismutase / Q000378:metabolism
chemical_list: D000975:Antioxidants; D008315:Malondialdehyde; D004317:Doxorubicin; D013482:Superoxide Dismutase; D005978:Glutathione