title: One-pot transition-metal-free synthesis of dibenzo[b,f]oxepins from 2-halobenzaldehydes.
abstract: A one-pot transition-metal-free, base-mediated synthesis of dibenzo[b,f]oxepins was developed. The reaction of 2-halobenzaldehydes with (2-hydroxyphenyl)acetonitriles proceeds via a sequential aldol condensation and intramolecular ether formation reaction in the presence of Cs(2)CO(3) and molecular sieves in toluene.
authors.affiliation: Medicinal Chemistry Research Center, Korea Research Institute of Chemical Technology, 141 Gajeong-ro, Daejeon 305-600, Korea.
authors.forename: Young Lok
authors.initials: YL
authors.lastname: Choi
authors.forename: Hye Sun
authors.initials: HS
authors.lastname: Lim
authors.forename: Hwan Jung
authors.initials: HJ
authors.lastname: Lim
authors.forename: Jung-Nyoung
authors.initials: JN
authors.lastname: Heo
mesh_terms: D001547:Benzaldehydes / Q000737:chemistry*; D001554:Benzene / Q000737:chemistry*; D007536:Isomerism; D008958:Models, Molecular; D015394:Molecular Structure; D010082:Oxepins / Q000138:chemical synthesis*
chemical_list: D001547:Benzaldehydes; D010082:Oxepins; D001554:Benzene; C032175:benzaldehyde