title: The effect of fetal anemia on fetal cardiac troponin T in pregnancies complicated by RhD alloimmunization.
abstract: OBJECTIVE
  To study the effect of fetal anemia on fetal cardiac troponin T (cTnT) in pregnancies complicated by RhD alloimmunization.
  
  
  METHODS
  Twenty pregnant women complicated by RhD alloimmunization who underwent intrauterine transfusion (IUT) for treatment of fetal anemia were studied. Immediately before IUT, fetal blood was obtained for hemoglobin and cTnT measurements.
  
  
  RESULTS
  Complete measurements of hemoglobin and cTnT before IUT were obtained in 49 procedures, of which 20 were first-time. The regression analysis between hemoglobin z-score and cTnT values in 49 procedures showed significant negative correlation (r = -0.43, p = 0.002, Regression equation Log(cTnT) = -1.5057 + -0.07563 Hb z-score). Cardiac TnT values before first IUT were significantly associated with perinatal death. In the group with elevated cTnT (n = 7), fetal or neonatal death was more frequent (2 IUD and 2 NND) when compared to normal cTnT group (n = 13, 1 IUD) (57.1 vs. 7.7%, p = 0.031, Fisher's exact test).
  
  
  CONCLUSIONS
  Fetal blood concentration of cTnT before IUT was negatively correlated to hemoglobin z-score, and levels of cTnT help to manage the pregnancies complicated by RhD alloimmunization.
authors.affiliation: Department of Obstetrics and Gynecology, Faculty of Medicine, University of São Paulo, São Paulo, Brazil. roseli.nomura@hotmail.com
authors.forename: Roseli Mieko Yamamoto
authors.initials: RM
authors.lastname: Nomura
authors.forename: Maria de Lourdes
authors.initials: Mde L
authors.lastname: Brizot
authors.forename: Adolfo Wenjaw
authors.initials: AW
authors.lastname: Liao
authors.forename: Estela Naomi
authors.initials: EN
authors.lastname: Nishie
authors.forename: Marcelo
authors.initials: M
authors.lastname: Zugaib
mesh_terms: D000328:Adult; D000740:Anemia; D001805:Blood Transfusion, Intrauterine; D015331:Cohort Studies; D004899:Erythroblastosis, Fetal / Q000097:blood / Q000378:metabolism / Q000628:therapy; D005260:Female; D005315:Fetal Diseases / Q000097:blood / Q000378:metabolism* / Q000628:therapy; D005318:Fetal Heart / Q000737:chemistry / Q000378:metabolism*; D006454:Hemoglobins / Q000032:analysis; D006801:Humans; D009206:Myocardium / Q000737:chemistry / Q000378:metabolism*; D009994:Osmolar Concentration; D011247:Pregnancy; D012203:Rh Isoimmunization / Q000097:blood / Q000378:metabolism* / Q000628:therapy; D020107:Troponin T / Q000097:blood*; D055815:Young Adult
chemical_list: D006454:Hemoglobins; D020107:Troponin T