title: Arterial stiffness is inversely related to plasma adiponectin levels in young normotensive patients with type 1 diabetes.
abstract: OBJECTIVE This study investigated the association between arterial stiffness and plasma adiponectin in patients with type 1 diabetes.  RESEARCH DESIGN AND METHODS Participants were normotensive patients with type 1 diabetes who were up to age 40 years. Subjects on statins with macrovascular disease or overt nephropathy were excluded. Large artery stiffness was assessed by measurement of carotid-femoral pulse wave velocity (PWV), whereas plasma adiponectin was measured by radioimmunoassay.  RESULTS Data from 80 patients (age 27.1 ± 6.1 years, BMI 24.2 ± 3.1 kg/m(2), HbA(1c) 7.5 ± 1.6%, 39 men, adiponectin 13.9 ± 6.7 μg/mL, and PWV 5.6 ± 0.9 m/s) were analyzed. Log adiponectin inversely correlated with age-adjusted PWV (r = -0.291, P = 0.009) and waist circumference (r = -0.427, P < 0.001). In a fully adjusted model, age, expiration/inspiration index, and log adiponectin were independently associated with PWV, explaining 39.6% of its variance.  CONCLUSIONS Arterial stiffness is inversely related to adiponectin concentration in young patients with type 1 diabetes without major complications.
authors.affiliation: First Propaedeutic Department of Medicine, Athens University Medical School, Laiko General Hospital, Athens, Greece. afro.tsiakou@gmail.com
authors.forename: Afroditi
authors.initials: A
authors.lastname: Tsiakou
authors.forename: Stavros
authors.initials: S
authors.lastname: Liatis
authors.forename: Kleopatra
authors.initials: K
authors.lastname: Alexiadou
authors.forename: Evanthia
authors.initials: E
authors.lastname: Diakoumopoulou
authors.forename: Konstantinos
authors.initials: K
authors.lastname: Makrilakis
authors.forename: Nicholas
authors.initials: N
authors.lastname: Tentolouris
authors.forename: Despoina
authors.initials: D
authors.lastname: Kyriaki
authors.forename: Nicholas
authors.initials: N
authors.lastname: Katsilambros
mesh_terms: D052242:Adiponectin / Q000097:blood*; D000328:Adult; D001794:Blood Pressure / Q000502:physiology*; D003922:Diabetes Mellitus, Type 1 / Q000097:blood* / Q000503:physiopathology*; D005260:Female; D006801:Humans; D008297:Male; D011863:Radioimmunoassay; D059289:Vascular Stiffness / Q000502:physiology*; D055815:Young Adult
chemical_list: D052242:Adiponectin