title: [Premature ovarian failure, from genetics to clinical].
abstract: Premature Ovarian Failure (POF) is a condition with complicated clinical presentation. An estimated 1% of the population is affected before the age of 40, with 0.1% affected prior to the age of 30. There are many causes of POI: genetic aberrations, auto-immune ovarian damage, iatrogenic factors following surgery, radiotherapy or chemotherapy, environmental factors (viruses, toxins, smoking) and metabolic. The majority of POF cases have idiopathic etiologies.
authors.affiliation: Département de Gynécologie et Obstétrique, Université de Liège, CRH de la Citadelle, Liège.
authors.forename: G
authors.initials: G
authors.lastname: Rege
authors.forename: J-M
authors.initials: JM
authors.lastname: Foidart
authors.forename: M
authors.initials: M
authors.lastname: Nisolle
authors.forename: A
authors.initials: A
authors.lastname: Pintiaux
authors.forename: A
authors.initials: A
authors.lastname: Béliard
mesh_terms: D000328:Adult; D005260:Female; D006801:Humans; D016649:Primary Ovarian Insufficiency / Q000209:etiology*