title: Eight flavonoids and their potential as inhibitors of human cytomegalovirus replication.
abstract: The drugs currently available for treatment of severe human cytomegalovirus (HCMV) infections suffer from many drawbacks, particularly toxicity, and potential teratogenicity contraindicating their use in target populations such as pregnant women. The emergence of drug-resistant strains is still a problem for disease management, particularly in immunosuppressed populations where antivirals are used for extended periods of time. The flavonoid family of drugs contains promising candidates as they have low toxicity and inhibit different targets to currently available antivirals. We report here that, unlike their chalcon homologs, four flavonoids (baicalein, quercetin, quercetagetin and naringenin) inhibit various stages of HCMV replication, the most active anti-HCMV compound being baicalein and the less active and less selective being quercetagetin. These drugs could provide potential inhibitors of virus replication alone or in combination, without increased toxicity.
authors.affiliation: Univ. Limoges, Inserm UMR 1092, Faculté de médecine, Limoges, France.
authors.forename: Sébastien
authors.initials: S
authors.lastname: Cotin
authors.forename: Claude-Alain
authors.initials: CA
authors.lastname: Calliste
authors.forename: Marie-Christine
authors.initials: MC
authors.lastname: Mazeron
authors.forename: Sébastien
authors.initials: S
authors.lastname: Hantz
authors.forename: Jean-Luc
authors.initials: JL
authors.lastname: Duroux
authors.forename: William D
authors.initials: WD
authors.lastname: Rawlinson
authors.forename: Marie-Cécile
authors.initials: MC
authors.lastname: Ploy
authors.forename: Sophie
authors.initials: S
authors.lastname: Alain
mesh_terms: D000998:Antiviral Agents / Q000737:chemistry / Q000494:pharmacology*; D002460:Cell Line; D003587:Cytomegalovirus / Q000187:drug effects* / Q000502:physiology; D005419:Flavonoids / Q000737:chemistry / Q000494:pharmacology*; D006801:Humans; D008826:Microbial Sensitivity Tests; D008958:Models, Molecular; D010948:Viral Plaque Assay; D014779:Virus Replication / Q000187:drug effects*
chemical_list: D000998:Antiviral Agents; D005419:Flavonoids