title: New phenolic compounds with anti-adipogenic activity from the aerial parts of Pulsatilla koreana.
abstract: Three new phenolic compounds, pulsatillosides A (1), B (2), and C (3), were isolated from the aerial parts of Pulsatilla koreana, together with two known flavonoid glycosides, trans-tiliroside (4) and kaempferol-3-O-β-glycoside (5). The structures of the isolated compounds were determined on the basis of spectroscopic analysis including 1D, 2D NMR and HR-MS. Among the isolated compounds, compounds 1-3 significantly inhibited adipocyte differentiation as measured by fat accumulation in 3 T3-L1 cells using Oil Red O staining.
authors.affiliation: College of Pharmacy, Chungbuk National University, Cheongju, Korea.
authors.forename: Qing
authors.initials: Q
authors.lastname: Liu
authors.forename: Jong Hoon
authors.initials: JH
authors.lastname: Ahn
authors.forename: Seon Beom
authors.initials: SB
authors.lastname: Kim
authors.forename: Bang Yeon
authors.initials: BY
authors.lastname: Hwang
authors.forename: Mi Kyeong
authors.initials: MK
authors.lastname: Lee
mesh_terms: D041721:3T3-L1 Cells; D017667:Adipocytes / Q000737:chemistry / Q000187:drug effects; D050156:Adipogenesis / Q000187:drug effects*; D000818:Animals; D001391:Azo Compounds / Q000737:chemistry; D005223:Fats / Q000737:chemistry; D005419:Flavonoids / Q000737:chemistry / Q000302:isolation & purification; D044949:Kaempferols / Q000737:chemistry / Q000302:isolation & purification; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D015394:Molecular Structure; D010636:Phenols / Q000737:chemistry* / Q000302:isolation & purification; D035261:Plant Components, Aerial / Q000737:chemistry*; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D031946:Pulsatilla / Q000737:chemistry*; D012503:Saponins / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D014315:Triterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology
chemical_list: D001391:Azo Compounds; D005223:Fats; D005419:Flavonoids; D044949:Kaempferols; D010636:Phenols; D010936:Plant Extracts; C473641:Pulsatilloside A; D012503:Saponins; D014315:Triterpenes; C112724:pulsatilloside C; C052083:tiliroside; C011049:oil red O