title: A subset of circulating microRNAs are predictive for cardiac death after discharge for acute myocardial infarction.
abstract: To investigate the prognostic impact of circulating microRNAs (miRs) in patients who survived acute myocardial infarction (AMI), we compared the circulating miR signature at the time of survival discharge among samples in the serum bank of the Osaka Acute Coronary Insufficiency Study. Using a high-throughput array consisting of 667 miRs, 11 miRs were found to be differentially expressed in the serum among patients at high-risk for cardiac death. Real-time RT-PCR confirmed that the serum levels of miR-155 and miR-380* were approximately 4- and 3-fold higher, respectively, in patients who experienced cardiac death within 1 year after discharge. Accordingly, a subset of circulating miRs might be predictive for cardiac death in post-AMI patients.
authors.affiliation: Department of Cardiovascular Medicine, Osaka University Graduate School of Medicine, Suita, Japan.
authors.forename: Sen
authors.initials: S
authors.lastname: Matsumoto
authors.forename: Yasuhiko
authors.initials: Y
authors.lastname: Sakata
authors.forename: Daisaku
authors.initials: D
authors.lastname: Nakatani
authors.forename: Shinichiro
authors.initials: S
authors.lastname: Suna
authors.forename: Hiroya
authors.initials: H
authors.lastname: Mizuno
authors.forename: Masahiko
authors.initials: M
authors.lastname: Shimizu
authors.forename: Masaya
authors.initials: M
authors.lastname: Usami
authors.forename: Tatsuya
authors.initials: T
authors.lastname: Sasaki
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Sato
authors.forename: Yukio
authors.initials: Y
authors.lastname: Kawahara
authors.forename: Toshimitsu
authors.initials: T
authors.lastname: Hamasaki
authors.forename: Shinsuke
authors.initials: S
authors.lastname: Nanto
authors.forename: Masatsugu
authors.initials: M
authors.lastname: Hori
authors.forename: Issei
authors.initials: I
authors.lastname: Komuro
mesh_terms: D000368:Aged; D015415:Biomarkers / Q000097:blood; D003643:Death; D005260:Female; D006801:Humans; D008297:Male; D035683:MicroRNAs / Q000097:blood*; D009203:Myocardial Infarction / Q000097:blood* / Q000401:mortality*; D010351:Patient Discharge; D011379:Prognosis
chemical_list: D015415:Biomarkers; D035683:MicroRNAs