title: Synthesis of iridium and ruthenium complexes with (N,N), (N,O) and (O,O) coordinating bidentate ligands as potential anti-cancer agents.
abstract: Several Ru-arene and Ir-Cp* complexes have been prepared incorporating (N,N), (N,O) and (O,O) coordinating bidentate ligands and have been found to be active against both HT-29 and MCF-7 cell lines. By incorporating a biologically active ligand into a metal complex the anti-cancer activity is increased.
authors.affiliation: School of Chemistry, University of Leeds, UK.
authors.forename: Stephanie J
authors.initials: SJ
authors.lastname: Lucas
authors.forename: Rianne M
authors.initials: RM
authors.lastname: Lord
authors.forename: Rachel L
authors.initials: RL
authors.lastname: Wilson
authors.forename: Roger M
authors.initials: RM
authors.lastname: Phillips
authors.forename: Visuvanathar
authors.initials: V
authors.lastname: Sridharan
authors.forename: Patrick C
authors.initials: PC
authors.lastname: McGowan
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D002470:Cell Survival / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D004354:Drug Screening Assays, Antitumor; D019073:HT29 Cells; D006801:Humans; D007495:Iridium / Q000737:chemistry*; D008024:Ligands; D061986:MCF-7 Cells; D008958:Models, Molecular; D015394:Molecular Structure; D009942:Organometallic Compounds / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D012428:Ruthenium / Q000737:chemistry*; D013329:Structure-Activity Relationship
chemical_list: D000970:Antineoplastic Agents; D008024:Ligands; D009942:Organometallic Compounds; D007495:Iridium; D012428:Ruthenium