title: Encapsulation of an adamantane-doxorubicin prodrug in pH-responsive polysaccharide capsules for controlled release.
abstract: Supramolecular microcapsules (SMCs) with the drug-loaded wall layers for pH-controlled drug delivery were designed and prepared. By using layer-by-layer (LbL) technique, the SMCs were constructed based on the self-assembly between polyaldenhyde dextran-graft-adamantane (PAD-g-AD) and carboxymethyl dextran-graft-β-CD (CMD-g-β-CD) on CaCO(3) particles via host-guest interaction. Simultaneously, adamantine-modified doxorubicin (AD-Dox) was also loaded on the LbL wall via host-guest interaction. The in vitro drug release study was carried out at different pHs. Because the AD groups were linked with PAD (PAD-g-AD) or Dox (AD-Dox) by pH-cleavable hydrazone bonds, AD moieties can be removed under the weak acidic condition, leading to destruction of SMCs and release of Dox. The pH-controlled drug release can enhance the uptake by tumor cells and thus achieve improved cancer therapy efficiency.
authors.affiliation: Key Laboratory of Biomedical Polymers of Ministry of Education & Department of Chemistry, Wuhan University, Wuhan 430072, PR China.
authors.forename: Guo-Feng
authors.initials: GF
authors.lastname: Luo
authors.forename: Xiao-Ding
authors.initials: XD
authors.lastname: Xu
authors.forename: Jing
authors.initials: J
authors.lastname: Zhang
authors.forename: Juan
authors.initials: J
authors.lastname: Yang
authors.forename: Yu-Hui
authors.initials: YH
authors.lastname: Gong
authors.forename: Qi
authors.initials: Q
authors.lastname: Lei
authors.forename: Hui-Zhen
authors.initials: HZ
authors.lastname: Jia
authors.forename: Cao
authors.initials: C
authors.lastname: Li
authors.forename: Ren-Xi
authors.initials: RX
authors.lastname: Zhuo
authors.forename: Xian-Zheng
authors.initials: XZ
authors.lastname: Zhang
mesh_terms: D000218:Adamantane / Q000737:chemistry*; D000903:Antibiotics, Antineoplastic / Q000737:chemistry* / Q000633:toxicity; D002119:Calcium Carbonate / Q000737:chemistry; D002214:Capsules / Q000737:chemistry*; D002470:Cell Survival / Q000187:drug effects; D003692:Delayed-Action Preparations; D004317:Doxorubicin / Q000737:chemistry* / Q000633:toxicity; D004337:Drug Carriers / Q000737:chemistry*; D006367:HeLa Cells; D006801:Humans; D006863:Hydrogen-Ion Concentration; D011134:Polysaccharides / Q000737:chemistry; D011355:Prodrugs / Q000737:chemistry* / Q000633:toxicity; D047392:beta-Cyclodextrins / Q000737:chemistry
chemical_list: D000903:Antibiotics, Antineoplastic; D002214:Capsules; D003692:Delayed-Action Preparations; D004337:Drug Carriers; D011134:Polysaccharides; D011355:Prodrugs; D047392:beta-Cyclodextrins; D004317:Doxorubicin; D002119:Calcium Carbonate; C031215:betadex; D000218:Adamantane