title: Effectiveness of a preoperative single dose intravenous dexamethasone in reducing the prevalence of postoperative sore throat after endotracheal intubation.
abstract: OBJECTIVE
  To evaluate the effectiveness of two-different doses of prophylactic dexamethasone intravenous administration in reducing the prevalence of postoperative sore throat following general endotracheal anesthesia.
  
  
  METHODS
  All patients (105 cases) of different procedures of elective surgery scheduled to have general anesthesia performed with endotracheal intubations were included. The subjects randomized into three pre-operative intravenous substance/drug administrations, group I (35 cases) with normal saline 2 ml, group II (35 cases) with dexamethasone 4 mg, and group III (35 cases) with dexamethasone 8 mg, respectively. The prevalence of sore throat and its severity was assessed, using visual analogue scale (VAS), scores of O to 10; 0 = no pain, and 10 = most severe pain.
  
  
  RESULTS
  Among three groups, the duration of surgery, and intubation-induced trauma had no statistical significance. The prevalence of sore throat at 1-hour/24-hour postoperative was 48.6/48.6%, 54.3/28.6%, and 54.3/42.9% in group I, II, and III respectively, and without statistical significance.
  
  
  CONCLUSIONS
  The intravenous dexamethasone had no significant effectiveness against postoperatively sore throat after endotracheal intubation.
authors.affiliation: Department of Surgery, Faculty of Medicine, Prince of Songkla University, Hat Yai, Songkhla, Thailand. rsakchai@medicine.psu.ac.th
authors.forename: Sakchai
authors.initials: S
authors.lastname: Ruangsin
authors.forename: Thunchanok
authors.initials: T
authors.lastname: Wanasuwannakul
authors.forename: Ngamjit
authors.initials: N
authors.lastname: Pattaravit
authors.forename: Wisara
authors.initials: W
authors.lastname: Asim
mesh_terms: D000328:Adult; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage*; D003907:Dexamethasone / Q000008:administration & dosage*; D005260:Female; D006801:Humans; D007275:Injections, Intravenous; D007442:Intubation, Intratracheal; D008297:Male; D008875:Middle Aged; D010149:Postoperative Pain / Q000517:prevention & control*; D011300:Preoperative Care; D015995:Prevalence; D017211:Treatment Failure; D055815:Young Adult
chemical_list: D000893:Anti-Inflammatory Agents; D003907:Dexamethasone