title: Polymorphism and tautomeric preference in fenobam and the utility of NLO response to detect polymorphic impurities.
abstract: Crystal structures of polymorphs and solvatomorphs of the potential anxiolytic drug fenobam exhibit an exclusive preference for one of the two possible tautomeric structures. A novel methodology based on nonlinear optical response has been successfully employed to detect the presence of a polymorphic impurity in a mixture of polymorphs.
authors.affiliation: Solid state and Structural Chemistry Unit, Indian Institute of Science, Bangalore 560012, India.
authors.forename: Sajesh P
authors.initials: SP
authors.lastname: Thomas
authors.forename: K
authors.initials: K
authors.lastname: Nagarajan
authors.forename: T N Guru
authors.initials: TN
authors.lastname: Row
mesh_terms: D018360:Crystallography, X-Ray; D007093:Imidazoles / Q000737:chemistry*; D008968:Molecular Conformation; D011789:Quantum Theory; D012997:Solvents / Q000737:chemistry
chemical_list: D007093:Imidazoles; D012997:Solvents; C032794:fenobam