title: [Research progress on the development of the strategies for siRNAs delivery in vivo].
abstract: RNA interference (RNAi) is a powerful endogenous process initiated by short double stranded RNAs, which results in sequence-specific posttranscriptional gene silencing. Because any protein that causes or contributes to a disease is susceptible to RNAi, the RNAi has high potential for therapeutic treatments. In a clinical setting, however, there are many obstacles to targeted delivery of small interfering RNA (siRNA) in vivo, specificity and stability of the RNAi reagents. In this review, we focus on recent progress in the development of efficient siRNA delivery vehicles to help the application of siRNA to in vivo therapy.
authors.affiliation: The School of Chemical & Biological Engineering, Lanzhou Jiaotong University, Lanzhou 730070, China.
authors.forename: Deping
authors.initials: D
authors.lastname: Tang
authors.forename: Aihong
authors.initials: A
authors.lastname: Mao
mesh_terms: D004337:Drug Carriers; D018014:Gene Transfer Techniques; D006801:Humans; D058990:Molecular Targeted Therapy / Q000379:methods / Q000639:trends; D034622:RNA Interference; D034741:RNA, Small Interfering / Q000008:administration & dosage / Q000235:genetics* / Q000378:metabolism; D014162:Transfection
chemical_list: D004337:Drug Carriers; D034741:RNA, Small Interfering