title: Stereotactic body radiation therapy for stage I non-small cell lung cancer patients with chronic respiratory insufficiency requiring domiciliary oxygen therapy.
abstract: BACKGROUND
  The efficacy of stereotactic body radiation therapy (SBRT) for patients treated with domiciliary oxygen therapy is not well-known.
  
  
  METHODS
  We collected the clinical records of 15 patients with chronic respiratory insufficiency requiring domiciliary oxygen therapy at 1-3 l/min who were treated with SBRT for stage I non-small cell lung cancer. All patients were fixed with a thermoplastic body cast system. SBRT was given in 7-8 fields with an isocenter dose of 40-60 Gy in 4-10 fractions (median, 48 Gy in 4 fractions).
  
  
  RESULTS
  The overall 2-year and 5-year survival rates for all patients were 67.4% and 34.7%, while the disease-specific 2-year and 5-year survival rates were 90.0% and 72.0%, respectively. Pulmonary adverse effects were mild in the majority of the patients, although two patients had grade 2 radiation pneumonitis. The oxygen flow required increased slightly at follow-up periods greater than one year, but was still at an acceptable level.
  
  
  CONCLUSIONS
  SBRT was feasible for patients requiring domiciliary oxygen therapy.
authors.affiliation: Department of Heavy Particle Therapy and Radiation Oncology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
authors.forename: Tadamasa
authors.initials: T
authors.lastname: Yoshitake
authors.forename: Katsumasa
authors.initials: K
authors.lastname: Nakamura
authors.forename: Yoshiyuki
authors.initials: Y
authors.lastname: Shioyama
authors.forename: Tomonari
authors.initials: T
authors.lastname: Sasaki
authors.forename: Saiji
authors.initials: S
authors.lastname: Ohga
authors.forename: Takeshi
authors.initials: T
authors.lastname: Nonoshita
authors.forename: Kotaro
authors.initials: K
authors.lastname: Terashima
authors.forename: Kaori
authors.initials: K
authors.lastname: Asai
authors.forename: Keiji
authors.initials: K
authors.lastname: Matsumoto
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Honda
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D002289:Carcinoma, Non-Small-Cell Lung / Q000150:complications* / Q000378:metabolism / Q000601:surgery*; D002908:Chronic Disease; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000150:complications* / Q000378:metabolism / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D010102:Oxygen Inhalation Therapy; D016634:Radiosurgery / Q000379:methods*; D012129:Respiratory Function Tests; D012131:Respiratory Insufficiency / Q000150:complications* / Q000628:therapy*; D012189:Retrospective Studies