title: Treatment of refractory neonatal seizures with topiramate.
abstract: OBJECTIVE
  The objective of this study is to describe the usefulness of topiramate in refractory neonatal seizures.
  
  
  RESULTS
  We reported the clinical off-label use of topiramate in three cases of refractory neonatal seizures of unclear origin with no response to conventional antiepileptic drugs. In all cases, the seizures were completely controlled with adding topiramate. All patients became seizure free during hospitalization and were followed by approximately 1 year after hospital discharge, with monotherapy with topiramate.
  
  
  CONCLUSIONS
  The clinical off-label use of topiramate in neonatal seizures is still incipient. When searching publications in this matter, only one report was identified. Because of its efficacy for both seizures and neuroprotection, topiramate could be a useful choice in refractory neonatal seizures.
authors.affiliation: Child Neurology Unit, Department of Pediatrics, UFRGS, Porto Alegre, Rio Grande do Sul, Brazil. rriesgo@hcpa.ufrgs.br
authors.forename: Rudimar
authors.initials: R
authors.lastname: Riesgo
authors.forename: Maria Isabel
authors.initials: MI
authors.lastname: Winckler
authors.forename: Lygia
authors.initials: L
authors.lastname: Ohlweiler
authors.forename: Josiane
authors.initials: J
authors.lastname: Ranzan
authors.forename: Michele
authors.initials: M
authors.lastname: Becker
authors.forename: Socrates
authors.initials: S
authors.lastname: Salvador
authors.forename: Luiza
authors.initials: L
authors.lastname: Magalhaes
authors.forename: Ricardo
authors.initials: R
authors.lastname: Ribeiro
mesh_terms: D000927:Anticonvulsants / Q000627:therapeutic use*; D004334:Drug Administration Schedule; D005260:Female; D005632:Fructose / Q000031:analogs & derivatives* / Q000627:therapeutic use; D006801:Humans; D007223:Infant; D008297:Male; D056687:Off-Label Use; D012640:Seizures / Q000188:drug therapy*; D000077236:Topiramate; D016896:Treatment Outcome
chemical_list: D000927:Anticonvulsants; D000077236:Topiramate; D005632:Fructose