title: Reference values of serum cystatin C in very low-birthweight premature infants.
abstract: OBJECTIVE
  To determine reference values for cystatin C (CysC) and its correlation with creatinine (Cr), gestational age, birthweight and maternal Cr status in very low-birthweight (VLBW) preterm infants.
  
  
  METHODS
  The study included 113 VLBW premature infants (<1500 g) of ≤ 32 gestational week. Serum Cr and CysC of the infant and serum Cr of the mother were analysed.
  
  
  RESULTS
  The mean level of CysC was 1.77 ± 0.38 mg/L on day 1 and 1.61 ± 0.37 mg/L on day 3, and the decrease was statistically significant. There was a significant correlation only between maternal Cr and first-day Cr values and negative correlations between Cr and gestational age and birthweight on third day. Creatinine was not correlated with CysC both on day 1 (r = -0.077, p = 0.417) and day 3 (r = 0.132, p = 0.164).
  
  
  CONCLUSIONS
  Here, we report the reference ranges for CysC and Cr on first and third day in VLBW infants. CysC concentrations significantly decrease by day 3 compared with day 1 and are independent of gestational week, birthweight and maternal renal function status in VLBW preterm infants.
authors.affiliation: Division of Neonatology, Samsun Maternity and Child Health Hospital, Samsun, Turkey. kgamze@hotmail.com
authors.forename: Gamze
authors.initials: G
authors.lastname: Demirel
authors.forename: Istemi H
authors.initials: IH
authors.lastname: Celik
authors.forename: Fuat E
authors.initials: FE
authors.lastname: Canpolat
authors.forename: Omer
authors.initials: O
authors.lastname: Erdeve
authors.forename: Zeynep
authors.initials: Z
authors.lastname: Biyikli
authors.forename: Ugur
authors.initials: U
authors.lastname: Dilmen
mesh_terms: D055316:Cystatin C / Q000097:blood*; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature / Q000097:blood*; D019102:Infant, Very Low Birth Weight / Q000097:blood*; D008297:Male; D012016:Reference Values
chemical_list: D055316:Cystatin C