title: Synthesis of β-ionone derived chalcones as potent antimicrobial agents.
abstract: A series of chalcones (3a-v) have been synthesized by condensation of β-ionone (1) with a variety of aldehydes (2a-v). The synthesized compounds have been screened for their in vitro antimicrobial activity against five bacterial and five fungal strains, using disc diffusion assay. The evaluated compounds display a wide range of activities, from completely inactive to the highly active compounds. Some of the compounds are also active against methicillin resistant staphylococcus aureus (MRSA).
authors.affiliation: Department of Pharmaceutical Sciences, Guru Nanak Dev University, Amritsar, Punjab, India.
authors.forename: Vishal
authors.initials: V
authors.lastname: Sharma
authors.forename: Gurpreet
authors.initials: G
authors.lastname: Singh
authors.forename: Harpreet
authors.initials: H
authors.lastname: Kaur
authors.forename: Ajit K
authors.initials: AK
authors.lastname: Saxena
authors.forename: Mohan Paul S
authors.initials: MP
authors.lastname: Ishar
mesh_terms: D000890:Anti-Infective Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects; D001424:Bacterial Infections / Q000188:drug therapy; D047188:Chalcones / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D005658:Fungi / Q000187:drug effects; D006801:Humans; D055624:Methicillin-Resistant Staphylococcus aureus / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D009181:Mycoses / Q000188:drug therapy; D045792:Norisoprenoids / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D013203:Staphylococcal Infections / Q000188:drug therapy
chemical_list: D000890:Anti-Infective Agents; D047188:Chalcones; D045792:Norisoprenoids; C008157:beta-ionone