title: Antitumour activities of sesquiterpene lactones from Inula helenium and Inula japonica.
abstract: Eight sesquiterpene lactones were isolated from the roots of Inula helenium and flowers of I. japonica. Among them, isoalantolactone (3) and santamarine (6) exhibited significant growth inhibitory activities against gynecologic cancer cell lines, while others weakly inhibited the growth of the cell lines (IC50 < or = 100 microM). In addition, 3 significantly inhibited the tumour growth of S180 tumour-bearing mice. Compounds 3 and 6 were not toxic to human embryonic lung fibroblast cells in vitro. These results demonstrated that the antitumour activities are closely related to the structures of the compounds, that is, an alpha-exomethylene-gamma-lactone ring is necessary for these activities.
authors.affiliation: Department of Forensic Medicine, Hebei Key Laboratory of Forensic Medicine, Hebei Medical University, Shijiazhuang 050017, Hebei Province, China.
authors.forename: Yong
authors.initials: Y
authors.lastname: Li
authors.forename: Zhi-Yu
authors.initials: ZY
authors.lastname: Ni
authors.forename: Meng-Chu
authors.initials: MC
authors.lastname: Zhu
authors.forename: Mei
authors.initials: M
authors.lastname: Dong
authors.forename: Si-Ming
authors.initials: SM
authors.lastname: Wang
authors.forename: Qing-Wen
authors.initials: QW
authors.lastname: Shi
authors.forename: Man-Li
authors.initials: ML
authors.lastname: Zhang
authors.forename: Yu-Fang
authors.initials: YF
authors.lastname: Wang
authors.forename: Chang-Hong
authors.initials: CH
authors.lastname: Huo
authors.forename: Hiromasa
authors.initials: H
authors.lastname: Kiyota
authors.forename: Bin
authors.initials: B
authors.lastname: Cong
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000494:pharmacology*; D045744:Cell Line, Tumor; D006801:Humans; D038143:Inula / Q000737:chemistry*; D007783:Lactones / Q000494:pharmacology*; D012717:Sesquiterpenes / Q000737:chemistry*
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D007783:Lactones; D012717:Sesquiterpenes