title: Fatal outcome after heart transplantation caused by Aspergillus lentulus.
abstract: Opportunistic invasive fungal infections are a major cause of mortality in immunocompromised patients. Early diagnosis of invasive aspergillosis and proper identification of the causative agent is crucial for guidance of therapy. Accurate differentiation of Aspergillus lentulus, a filamentous fungus often misidentified as atypical Aspergillus fumigatus, is of concern as multiple antifungal drugs show a reduced susceptibility. This is the first report, to our knowledge, of a proven pulmonary invasive fungal infection caused by A. lentulus after heart transplantation.
authors.affiliation: Institute of Medical Microbiology, University of Zurich, Zurich, Switzerland. azbinden@imm.uzh.ch
authors.forename: A
authors.initials: A
authors.lastname: Zbinden
authors.forename: A
authors.initials: A
authors.lastname: Imhof
authors.forename: M J
authors.initials: MJ
authors.lastname: Wilhelm
authors.forename: F
authors.initials: F
authors.lastname: Ruschitzka
authors.forename: P
authors.initials: P
authors.lastname: Wild
authors.forename: G V
authors.initials: GV
authors.lastname: Bloemberg
authors.forename: N J
authors.initials: NJ
authors.lastname: Mueller
mesh_terms: D000368:Aged; D000935:Antifungal Agents / Q000627:therapeutic use; D001230:Aspergillus / Q000145:classification / Q000302:isolation & purification*; D017809:Fatal Outcome; D016027:Heart Transplantation / Q000009:adverse effects*; D006801:Humans; D016867:Immunocompromised Host; D055744:Invasive Pulmonary Aspergillosis / Q000188:drug therapy / Q000382:microbiology*; D008297:Male; D009894:Opportunistic Infections / Q000188:drug therapy / Q000382:microbiology*
chemical_list: D000935:Antifungal Agents