title: Recent progress in studies of metallic nickel and nickel-based nanoparticles' genotoxicity and carcinogenicity.
abstract: Recently, nanoparticles have been the focus of many research and innovation. Metallic nickel and nickel-based nanoparticles are among those being exploited. Nickel fine particles are known to be genotoxic and carcinogenic. It has been discovered that many properties of nano sized elements and materials are not present in their bulk states. The nano size of these particles renders them the ability to be easily transported into biological systems, thus raising the question of their effects on the susceptible system. Therefore scientific research on the effects of nickel nanoparticles is important. This mini-review intends to summarize the current knowledge on the genotoxicity and carcinogenicity potential of metallic nickel and nickel-based nanoparticles implicated in in vitro and in vivo mammalian studies.
authors.affiliation: Department of Preventive Medicine of the Medical School, Zhejiang Provincial Key Laboratory of Pathological and Physiological Technology, Ningbo University, Ningbo, Zhejiang 315211, PR China.
authors.forename: Ruth
authors.initials: R
authors.lastname: Magaye
authors.forename: Jinshun
authors.initials: J
authors.lastname: Zhao
mesh_terms: D002273:Carcinogens / Q000633:toxicity*; D004249:DNA Damage; D004781:Environmental Exposure / Q000706:statistics & numerical data; D053768:Metal Nanoparticles / Q000633:toxicity*; D009153:Mutagens / Q000633:toxicity*; D009532:Nickel / Q000633:toxicity*; D010316:Particle Size; D018570:Risk Assessment; D018675:Toxicity Tests
chemical_list: D002273:Carcinogens; D009153:Mutagens; D009532:Nickel