title: Chronic obstructive pulmonary disease and longitudinal changes in pulmonary function due to occupational exposure to respirable quartz.
abstract: OBJECTIVE
  The present study sought to examine the long-term effects of exposure to respirable quartz on pulmonary function with particular focus on chronic obstructive pulmonary disease (COPD).
  
  
  METHODS
  The study is based on the Wismut cohort of former uranium miners. Spirometric data were ascertained together with quantitative estimates of cumulative exposure to respirable quartz for each of 1421 study subjects born between 1954 and 1956. The case definition for COPD is based on the criteria of the Global Initiative for Chronic Obstructive Lung Disease. Linear mixed regression models were fitted to identify significant determinants of longitudinal changes in lung function parameters.
  
  
  RESULTS
  An average of five spirometries were available for each miner. It was shown that cumulative exposure to 1 mg/m(3)-year respirable quartz leads, on average, to a relative reduction in forced expiratory volume in 1 s/ orced vital capacity (FEV(1)/FVC) of 2.75% (p<0.001). A nested case-control approach demonstrated that the risk for COPD stage I increases with increasing cumulative exposure to respirable quartz (OR 1.81 per 1 mg/m(3)-year).
  
  
  CONCLUSIONS
  This paper adds further evidence on the long-term effects of exposure to respirable quartz, which include a decline in pulmonary function parameters and an increase in the incidence of COPD.
authors.affiliation: Department of Work and Health, Federal Institute for Occupational Safety and Health, Berlin, Germany. Moehner.Matthias@baua.bund.de
authors.forename: Matthias
authors.initials: M
authors.lastname: Möhner
authors.forename: Norbert
authors.initials: N
authors.lastname: Kersten
authors.forename: Johannes
authors.initials: J
authors.lastname: Gellissen
mesh_terms: D000293:Adolescent; D000328:Adult; D016022:Case-Control Studies; D005541:Forced Expiratory Volume; D006801:Humans; D019570:Inhalation Exposure / Q000009:adverse effects; D008137:Longitudinal Studies; D008168:Lung / Q000187:drug effects* / Q000503:physiopathology; D008906:Mining; D009784:Occupational Diseases / Q000209:etiology* / Q000503:physiopathology; D016273:Occupational Exposure / Q000009:adverse effects*; D029424:Pulmonary Disease, Chronic Obstructive / Q000209:etiology* / Q000503:physiopathology; D011791:Quartz / Q000009:adverse effects*; D012307:Risk Factors; D013147:Spirometry; D014501:Uranium; D055815:Young Adult
chemical_list: D011791:Quartz; D014501:Uranium