title: Soy isoflavones modulate adipokines and myokines to regulate lipid metabolism in adipose tissue, skeletal muscle and liver of male Huanjiang mini-pigs.
abstract: Although a growing body of evidence suggests that soy isoflavones help regulate lipid metabolism, the underlying mechanism has not yet been thoroughly clarified. The present study was undertaken to determine the effects of soy isoflavones on the expression of genes involved in lipid metabolism in different adipose tissue depots, skeletal muscle and liver of male Huanjiang mini-pigs, as well as the expression of adipokines and myokines. A total of 36 male Huanjiang mini-pigs were fed basal diet (control, Con), low-dose soy isoflavones (LSI) and high-dose soy isoflavones (HSI). The results showed that LSI and HSI regulated the expression of genes involved in the anabolism and catabolism of fatty acids in dorsal subcutaneous (DSA), abdominal subcutaneous (ASA) and perirenal (PRA) adipose tissue depots, as well as longissimus dorsi muscle (LDM) and liver. LSI and HSI also regulated the expression of adipokines in DSA, ASA and PRA, and the expression of myokines in LDM in male Huanjiang mini-pigs. In addition, soy isoflavones regulated plasma glucose, leptin and adiponectin contents after treatment for two months. Our results indicate that soy isoflavones, by regulating the expression of adipokines and myokines, may regulate the metabolism of lipids and could have potential therapeutic applications in lipid abnormalities.
authors.affiliation: Chinese Acad Sci, Inst Subtrop Agr, Res Ctr Healthy Breeding Livestock & Poultry, Hunan Engn & Res Ctr Anim & Poultry Sci, Key Lab Agroecol Proc Subtrop Reg, Scientific Oberving and Experimetal Station of Animal Nutrition and Feed Science in South-Central, Ministry of Agriculture, Changsha, 410125 Hunan, China.
authors.forename: Huansheng
authors.initials: H
authors.lastname: Yang
authors.forename: Fengna
authors.initials: F
authors.lastname: Li
authors.forename: Xia
authors.initials: X
authors.lastname: Xiong
authors.forename: Xiangfeng
authors.initials: X
authors.lastname: Kong
authors.forename: Bin
authors.initials: B
authors.lastname: Zhang
authors.forename: Xiaoxue
authors.initials: X
authors.lastname: Yuan
authors.forename: Juexin
authors.initials: J
authors.lastname: Fan
authors.forename: Yefei
authors.initials: Y
authors.lastname: Duan
authors.forename: Meimei
authors.initials: M
authors.lastname: Geng
authors.forename: Lili
authors.initials: L
authors.lastname: Li
authors.forename: Yulong
authors.initials: Y
authors.lastname: Yin
mesh_terms: D054392:Adipokines / Q000097:blood / Q000378:metabolism*; D000273:Adipose Tissue / Q000201:enzymology / Q000254:growth & development / Q000378:metabolism*; D000821:Animal Feed; D000818:Animals; D017849:Animals, Inbred Strains; D002681:China; D016207:Cytokines / Q000378:metabolism*; D005786:Gene Expression Regulation; D007529:Isoflavones / Q000008:administration & dosage / Q000378:metabolism*; D050356:Lipid Metabolism; D008099:Liver / Q000201:enzymology / Q000254:growth & development / Q000378:metabolism*; D008297:Male; D018482:Muscle, Skeletal / Q000201:enzymology / Q000254:growth & development / Q000378:metabolism*; D009928:Organ Specificity; D010936:Plant Extracts / Q000737:chemistry; D012639:Seeds / Q000737:chemistry; D013025:Glycine max / Q000737:chemistry; D013552:Swine; D013556:Swine, Miniature; D015430:Weight Gain
chemical_list: D054392:Adipokines; D016207:Cytokines; D007529:Isoflavones; D010936:Plant Extracts