title: The white coat effect is not associated with additional increase of target organ damage in true resistant hypertension.
abstract: OBJECTIVE
  White coat effect (WCE) (i.e., the difference between office blood pressure [OBP] and awake ambulatory blood pressure monitoring [ABPM]) may be present in hypertensive individuals. The relationship between occurrence of WCE and target organ damage (TOD) has not yet been assessed in true resistant hypertension (RHTN).
  
  
  METHODS
  RHTN patients were divided into two groups: RHTN with WCE (WCE, n=66) and RHTN without WCE (non-WCE, n=61). All patients were submitted to OBP measurement, ABPM, echocardiography and renal function evaluation in three visits.
  
  
  RESULTS
  No differences were observed between the WCE and non-WCE groups regarding age, body mass index or gender. OBP were 169.8±15.8/95.1±14.0 (WCE) and 161.9±9.0/90.1±10.4mmHg (non-WCE), ABPM=143.0±12.8/86.1±9.9 (WCE) and 146.1±13.6/85.1±14.9mmHg (non-WCE). No statistical differences were observed between WCE and non-WCE subgroups with respect to left ventricular mass index (LVMI) (WCE=131±4.7; non-WCE=125±2.9g/m(2)), creatinine clearance (WCE=78±4.7; non-WCE=80±3.6ml/min/m(2)) and microalbuminuria (MA) (WCE=44±8.4; non-WCE=49±6.8mg/g Cr).
  
  
  CONCLUSIONS
  This finding may suggest that WCE is not associated with additional increase of TOD in true RHTN subjects.
authors.affiliation: Cardiovascular Pharmacology Laboratory, Faculty of Medical Sciences, University of Campinas (Unicamp), Campinas, SP, Brazil.
authors.forename: Valéria Nasser
authors.initials: VN
authors.lastname: Figueiredo
authors.forename: Luiz Cláudio
authors.initials: LC
authors.lastname: Martins
authors.forename: Leandro
authors.initials: L
authors.lastname: Boer-Martins
authors.forename: Ana Paula
authors.initials: AP
authors.lastname: Cabral de Faria
authors.forename: Carolina
authors.initials: C
authors.lastname: de Haro Moraes
authors.forename: Rodrigo
authors.initials: R
authors.lastname: Cardoso Santos
authors.forename: Armando R
authors.initials: AR
authors.lastname: Nogueira
authors.forename: Heitor
authors.initials: H
authors.lastname: Moreno
mesh_terms: D000368:Aged; D000419:Albuminuria / Q000097:blood / Q000209:etiology*; D000959:Antihypertensive Agents / Q000008:administration & dosage / Q000627:therapeutic use; D001795:Blood Pressure Determination; D018660:Blood Pressure Monitoring, Ambulatory; D003131:Combined Modality Therapy; D003404:Creatinine / Q000097:blood; D004039:Diet, Sodium-Restricted; D004351:Drug Resistance; D004359:Drug Therapy, Combination; D050171:Dyslipidemias / Q000097:blood / Q000150:complications; D000075222:Essential Hypertension; D005260:Female; D006801:Humans; D006943:Hyperglycemia / Q000097:blood / Q000150:complications; D006973:Hypertension / Q000097:blood / Q000150:complications* / Q000178:diet therapy / Q000188:drug therapy / Q000503:physiopathology; D017379:Hypertrophy, Left Ventricular / Q000000981:diagnostic imaging / Q000209:etiology*; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000097:blood / Q000150:complications / Q000503:physiopathology; D011379:Prognosis; D016037:Single-Blind Method; D014463:Ultrasonography; D059466:White Coat Hypertension / Q000150:complications* / Q000503:physiopathology
chemical_list: D000959:Antihypertensive Agents; D003404:Creatinine