title: High prevalence of amantadine-resistant influenza A virus isolated in Gyeonggi Province, South Korea, during 2005-2010.
abstract: Amantadine resistance among influenza A viruses was investigated in South Korea in 2005-2010. Of 308 influenza A viruses examined, 229 had the S31N substitution in the M2 protein. The frequency of amantadine resistance was 30 %, 100 %, and 76 % in influenza A/H1N1, pandemic A/H1N1 2009(A/H1N1pdm), and A/H3N2 subtypes, respectively. The amantadine-resistant influenza A/H1N1pdm and A/H3N2 viruses were circulating continuously from 2008 to 2009 and from 2005 to 2006, respectively. Amantadine resistance among influenza A viruses increased dramatically during the 5-year study period, and this has diminished the usefulness of this class of drugs.
authors.affiliation: Gyeonggi-do Institute of Health and Environment, Suwon, Gyeonggi-do, South Korea.
authors.forename: Han-Gil
authors.initials: HG
authors.lastname: Cho
authors.forename: Jang-Hoon
authors.initials: JH
authors.lastname: Choi
authors.forename: Woon-Ho
authors.initials: WH
authors.lastname: Kim
authors.forename: Hae-Kun
authors.initials: HK
authors.lastname: Hong
authors.forename: Mi-Hye
authors.initials: MH
authors.lastname: Yoon
authors.forename: Eek-Hoon
authors.initials: EH
authors.lastname: Jho
authors.forename: Chun
authors.initials: C
authors.lastname: Kang
authors.forename: Young-Hee
authors.initials: YH
authors.lastname: Lim
mesh_terms: D000547:Amantadine / Q000494:pharmacology*; D000998:Antiviral Agents / Q000494:pharmacology*; D024882:Drug Resistance, Viral; D006801:Humans; D053118:Influenza A Virus, H1N1 Subtype / Q000145:classification / Q000187:drug effects* / Q000235:genetics / Q000302:isolation & purification; D053122:Influenza A Virus, H3N2 Subtype / Q000145:classification / Q000187:drug effects* / Q000235:genetics / Q000302:isolation & purification; D007251:Influenza, Human / Q000188:drug therapy / Q000453:epidemiology / Q000821:virology*; D008969:Molecular Sequence Data; D010802:Phylogeny; D056910:Republic of Korea / Q000453:epidemiology
chemical_list: D000998:Antiviral Agents; D000547:Amantadine