title: Upregulation of hsa-miR-125b in HTLV-1 asymptomatic carriers and HTLV-1-associated myelopathy/tropical spastic paraparesis patients.
abstract: The retrovirus human T lymphotropic virus type 1 (HTLV-1) promotes spastic paraparesis, adult T cell leukaemia and other diseases. Recently, some human microRNAs (miRNAs) have been described as important factors in host-virus interactions. This study compared miRNA expression in control individuals, asymptomatic HTLV-1 carriers and HTLV-1 associated myelopathy (HAM)/tropical spastic paraparesis patients. The proviral load and Tax protein expression were measured in order to characterize the patients. hsa-miR-125b expression was significantly higher in patients than in controls (p = 0.0285) or in the HAM group (p = 0.0312). Therefore, our findings suggest that miR-125b expression can be used to elucidate the mechanisms of viral replication and pathogenic processes.
authors.affiliation: Departamento de Análises Clínicas, Toxicológicas e Bromatológicas, Faculdade de Ciências Farmacêuticas de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, SP, Brasil. larissanicolete@gmail.com
authors.forename: Larissa Deadame de Figueiredo
authors.initials: LD
authors.lastname: Nicolete
authors.forename: Roberto
authors.initials: R
authors.lastname: Nicolete
authors.forename: Rodrigo
authors.initials: R
authors.lastname: Haddad
authors.forename: Rochele
authors.initials: R
authors.lastname: Azevedo
authors.forename: Fabíola Attié de
authors.initials: FA
authors.lastname: Castro
authors.forename: Yuetsu
authors.initials: Y
authors.lastname: Tanaka
authors.forename: Osvaldo Massaiti
authors.initials: OM
authors.lastname: Takayanagui
authors.forename: Dimas Tadeu
authors.initials: DT
authors.lastname: Covas
authors.forename: Simone
authors.initials: S
authors.lastname: Kashima
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000378:metabolism; D002353:Carrier State; D016022:Case-Control Studies; D005260:Female; D005434:Flow Cytometry; D016356:Gene Products, tax / Q000378:metabolism*; D015368:Human T-lymphotropic virus 1 / Q000254:growth & development; D006801:Humans; D008297:Male; D035683:MicroRNAs / Q000378:metabolism*; D008875:Middle Aged; D015493:Paraparesis, Tropical Spastic / Q000378:metabolism* / Q000821:virology; D015854:Up-Regulation; D019562:Viral Load; D014779:Virus Replication
chemical_list: D015415:Biomarkers; D016356:Gene Products, tax; C531888:MIRN125 microRNA, human; D035683:MicroRNAs; C514970:tax protein, Human T-lymphotrophic virus 1