title: Alzheimer disease: from inherited to sporadic AD-crossing the biomarker bridge.
abstract: Whether dominantly inherited variants of Alzheimer disease (AD) and 'sporadic' forms exhibit similar pathophysiological and biomarker signatures remains unresolved. A landmark study has proposed a biomarker progression model of dominantly inherited AD, but a complex systems biology and physiology approach is required to translate these findings to sporadic disease.
authors.affiliation: Department of Psychiatry, Goethe University, Frankfurt am Main, Germany. harald.hampel@med.uni-muenchen.de
authors.forename: Harald
authors.initials: H
authors.lastname: Hampel
authors.forename: Simone
authors.initials: S
authors.lastname: Lista
mesh_terms: D000544:Alzheimer Disease / Q000134:cerebrospinal fluid* / Q000175:diagnosis* / Q000235:genetics; D015415:Biomarkers / Q000134:cerebrospinal fluid; D018450:Disease Progression; D005819:Genetic Markers / Q000235:genetics*; D006801:Humans
chemical_list: D015415:Biomarkers; D005819:Genetic Markers