title: [Indications and use of prothrombin complex in cardiac surgery].
abstract: On of the most common, and serious, complications in cardiac surgery is postoperative bleeding. According to the majority of studies, between 10% and 92% of patients subjected to elective surgery require transfusions of blood products and blood derivatives. Transfusions and reinterventions are associated with longer stays in critical care units and a decrease in survival rates. There have been some important changes in the treatment of changes in haemostasis and post-surgical bleeding in the last few years, particularly with the introduction into clinical practice of working procedures backed up by clinical guidelines, as well as the appearance of new drugs. The aim of this work is to describe the main characteristics and update the use of prothrombin complexes that are currently available in Spain, with special emphasis on their use in cardiac surgery.
authors.affiliation: Servicio de Anestesiología y Reanimación, Hospital Universitario La Fe, Valencia, España. Electronic address: pajares_maz@gva.es.
authors.forename: A
authors.initials: A
authors.lastname: Pajares
authors.forename: R
authors.initials: R
authors.lastname: Vicente
authors.forename: L
authors.initials: L
authors.lastname: Larrea
authors.forename: J L
authors.initials: JL
authors.lastname: Vicente
authors.forename: M
authors.initials: M
authors.lastname: Barberá
mesh_terms: D000925:Anticoagulants / Q000009:adverse effects; D001779:Blood Coagulation Factors / Q000008:administration & dosage / Q000009:adverse effects / Q000191:economics / Q000600:supply & distribution / Q000627:therapeutic use*; D016063:Blood Loss, Surgical; D017848:Blood-Borne Pathogens; D006348:Cardiac Surgical Procedures; D000075202:Contraindications; D018562:Disease Transmission, Infectious / Q000517:prevention & control; D004340:Drug Contamination; D016527:Drug Costs; D006331:Heart Diseases / Q000150:complications / Q000601:surgery; D006474:Hemorrhagic Disorders / Q000235:genetics; D006490:Hemostatics / Q000008:administration & dosage / Q000009:adverse effects / Q000191:economics / Q000600:supply & distribution / Q000627:therapeutic use*; D006801:Humans; D019106:Postoperative Hemorrhage / Q000188:drug therapy* / Q000517:prevention & control; D011229:Preanesthetic Medication; D019851:Thrombophilia / Q000150:complications / Q000188:drug therapy; D013927:Thrombosis / Q000139:chemically induced; D014812:Vitamin K / Q000037:antagonists & inhibitors
chemical_list: D000925:Anticoagulants; D001779:Blood Coagulation Factors; D006490:Hemostatics; D014812:Vitamin K; C025667:prothrombin complex concentrates