title: Preferred antiretroviral drugs for the next decade of scale up.
abstract: Global commitments aim to provide antiretroviral therapy (ART) to 15 million people living with HIV by 2015, and recent studies have demonstrated the potential for widespread ART to prevent HIV transmission. Increasingly, countries are adapting their national guidelines to start ART earlier, for both clinical and preventive benefits. To maximize the benefits of ART in resource-limited settings, six key principles need to guide ART choice: simplicity, tolerability and safety, durability, universal applicability, affordability and heat stability. Currently available drugs, combined with those in late-stage clinical development, hold great promise to simplify treatment in the short term. Over the longer-term, newer technologies, such as long-acting formulations and nanotechnology, could radically alter the treatment paradigm. This commentary reviews recommendations made in an expert consultation on treatment scale up in resource-limited settings.
authors.affiliation: Médecins Sans Frontières, Geneva, Switzerland.
authors.forename: Isabelle
authors.initials: I
authors.lastname: Andrieux-Meyer
authors.forename: Alexandra
authors.initials: A
authors.lastname: Calmy
authors.forename: Pedro
authors.initials: P
authors.lastname: Cahn
authors.forename: Polly
authors.initials: P
authors.lastname: Clayden
authors.forename: Gilles
authors.initials: G
authors.lastname: Raguin
authors.forename: Christine
authors.initials: C
authors.lastname: Katlama
authors.forename: Marco
authors.initials: M
authors.lastname: Vitoria
authors.forename: Andrew
authors.initials: A
authors.lastname: Levin
authors.forename: Sharonann
authors.initials: S
authors.lastname: Lynch
authors.forename: Eric
authors.initials: E
authors.lastname: Goemaere
authors.forename: Nathan
authors.initials: N
authors.lastname: Ford
mesh_terms: D044966:Anti-Retroviral Agents / Q000008:administration & dosage*; D023241:Antiretroviral Therapy, Highly Active / Q000379:methods*; D017408:Guidelines as Topic; D015658:HIV Infections / Q000188:drug therapy* / Q000517:prevention & control; D006801:Humans
chemical_list: D044966:Anti-Retroviral Agents