title: Non-fasting blood glucose and risk of incident coronary heart disease in middle-aged general population: the Circulatory Risk in Communities Study (CIRCS).
abstract: OBJECTIVE
  The objective was to determine whether non-fasting glucose concentration is a predictor for incident coronary heart disease.
  
  
  METHODS
  We investigated a cohort data of 9,900 40- to 69-year-old residents in four Japanese communities for 1975-1986 baseline surveys of the Circulatory Risk in Communities Study (CIRCS). Non-fasting blood glucose concentrations were available for 7,332 participants. Diabetic type was defined as a glucose level of ≥ 11.1 mmol/L and/or the use of medication for diabetes mellitus.
  
  
  RESULTS
  A total of 170 coronary heart disease including 113 myocardial infarctions occurred in non-fasting participants within the median 22-year follow-up period. Multivariable hazard ratios (HRs) of incident coronary heart disease for the participants with diabetic type compared with the normal type were 1.98 (0.84-4.68) for men, 3.39 (1.47-7.81) for women, and 2.47 (1.37-4.46) for total subjects. Corresponding HRs for myocardial infarction were 2.14 (0.83-5.55), 5.70 (2.21-14.67) and 3.17 (1.65-6.10), respectively. Multivariable HRs of incident coronary heart disease per one standard deviation of serum glucose levels were 1.17 (1.02-1.36), 1.19 (1.03-1.38), and 1.19 (1.08-1.32), respectively. The corresponding HRs for myocardial infarction were 1.18 (1.00-1.38), 1.27 (1.07-1.49) and 1.23 (1.10-1.37).
  
  
  CONCLUSIONS
  Non-fasting glucose concentration, either as diagnosis of diabetic type or as continuous variable, proved to be an independent predictor for incident coronary heart disease in middle-aged general population.
authors.affiliation: Public Health, Department of Social and Environmental Medicine, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, Suita 565-0871, Japan. imano@pbhel.med.osaka-u.ac.jp
authors.forename: Hironori
authors.initials: H
authors.lastname: Imano
authors.forename: Hiroyasu
authors.initials: H
authors.lastname: Iso
authors.forename: Masahiko
authors.initials: M
authors.lastname: Kiyama
authors.forename: Kazumasa
authors.initials: K
authors.lastname: Yamagishi
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Ohira
authors.forename: Shinichi
authors.initials: S
authors.lastname: Sato
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Noda
authors.forename: Kenji
authors.initials: K
authors.lastname: Maeda
authors.forename: Takeo
authors.initials: T
authors.lastname: Okada
authors.forename: Takeshi
authors.initials: T
authors.lastname: Tanigawa
authors.forename: Akihiko
authors.initials: A
authors.lastname: Kitamura
mesh_terms: D000328:Adult; D000368:Aged; D015415:Biomarkers / Q000097:blood; D001786:Blood Glucose / Q000032:analysis*; D015331:Cohort Studies; D003324:Coronary Artery Disease / Q000453:epidemiology / Q000209:etiology*; D003920:Diabetes Mellitus / Q000175:diagnosis; D005260:Female; D006801:Humans; D015994:Incidence; D007564:Japan / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000453:epidemiology; D016016:Proportional Hazards Models; D018570:Risk Assessment / Q000379:methods
chemical_list: D015415:Biomarkers; D001786:Blood Glucose