title: Structure and dynamics of cardiotoxins.
abstract: Cytotoxins (or cardiotoxins; CTs) are toxins from cobra venom characterized by the three-finger (TF) fold. CTs are on average 60-residue-long peptides, possessing as many as 4 disulfide bonds. The elements of antiparallel β-structure take origin from the hydrophobic core formed by the disulfides. The β-strands adopt the shape of the three loops, giving the name of the fold. While neurotoxins (NTs) - also TF proteins from snake venom - exert their effect through specific interactions with protein receptors, no specific protein target has been found for CTs. Unlike NTs, CTs are amphiphilic and cytotoxic against a variety of cells, including cancer ones. Thus, the hypothesis that the activity of CTs is caused by their interactions with lipid membranes is currently central. To understand molecular basis behind variations in toxicities of CTs highly homologous in their sequences, detailed knowledge of their structure and dynamics is required. The present review summarizes experimental and computational data on the spatial organization of CTs and their dynamics in various environments (aqueous solution, membranous milieus).
authors.affiliation: Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, 16/10 Miklukho-Maklaya str., 117997 GSP, Moscow V-437, Russia.
authors.forename: Anastasia G
authors.initials: AG
authors.lastname: Konshina
authors.forename: Peter V
authors.initials: PV
authors.lastname: Dubovskii
authors.forename: Roman G
authors.initials: RG
authors.lastname: Efremov
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D054715:Cardiotoxins / Q000737:chemistry* / Q000378:metabolism* / Q000633:toxicity; D002462:Cell Membrane / Q000187:drug effects / Q000378:metabolism; D006801:Humans; D008969:Molecular Sequence Data
chemical_list: D054715:Cardiotoxins