title: Dynamic regulation on energy landscape evolution of single-molecule protein by conformational fluctuation.
abstract: We formalize a theory to help explore the effect of conformational fluctuation on the energy landscape evolution of single-molecule protein. Using this formalization, we investigate the photon emission from single photoactivated fluorescent protein. A bimodal regulation on the energy landscape evolution was discovered, and its origin was attributed to slow conformational fluctuations of the protein matrix.
authors.affiliation: Department of Photonics and Institute of Electro-Optical Engineering, Chiao Tung University, Hsinchu 300, Taiwan, Republic of China.
authors.forename: Chien Y
authors.initials: CY
authors.lastname: Lin
authors.forename: Jung Y
authors.initials: JY
authors.lastname: Huang
authors.forename: Leu-Wei
authors.initials: LW
authors.lastname: Lo
mesh_terms: D007834:Lasers; D008164:Luminescent Proteins / Q000737:chemistry*; D008958:Models, Molecular; D017785:Photons; D011487:Protein Conformation; D013269:Stochastic Processes; D013816:Thermodynamics
chemical_list: D008164:Luminescent Proteins