title: Splenic marginal zone lymphoma in a HIV-1 infected patient: evidence favouring a pathogenetic role of HIV-1 itself in the lymphomagenesis.
abstract: A rare case of splenic marginal zone lymphoma (SMZL) in a human immunodeficiency virus (HIV)-1 infected patient is described. As an association between SMZL and viral infections has been reported, the presence of the hepatitis C virus and HIV-1 genomes was evaluated. Only HIV-1 DNA levels were detected in enriched splenic B lymphocytes, suggesting a HIV-1 involvement in lymphomagenesis.
authors.affiliation: Department of Clinical Medicine, Sapienza University of Rome, Viale dell'Università 37, 00185, Rome, Italy.
authors.forename: M
authors.initials: M
authors.lastname: Cagliuso
authors.forename: V
authors.initials: V
authors.lastname: Conti
authors.forename: S
authors.initials: S
authors.lastname: Trasarti
authors.forename: L
authors.initials: L
authors.lastname: Lombardi
authors.forename: M
authors.initials: M
authors.lastname: Riminucci
authors.forename: M
authors.initials: M
authors.lastname: Perez
authors.forename: O
authors.initials: O
authors.lastname: Turriziani
authors.forename: F
authors.initials: F
authors.lastname: Falasca
authors.forename: M
authors.initials: M
authors.lastname: Nanni
authors.forename: A
authors.initials: A
authors.lastname: Tafuri
authors.forename: I
authors.initials: I
authors.lastname: Mezzaroma
mesh_terms: D002472:Cell Transformation, Viral; D005260:Female; D015658:HIV Infections / Q000150:complications* / Q000188:drug therapy / Q000821:virology; D015497:HIV-1 / Q000472:pathogenicity*; D006801:Humans; D018442:Lymphoma, B-Cell, Marginal Zone / Q000175:diagnosis / Q000209:etiology*; D008875:Middle Aged; D013154:Spleen / Q000473:pathology; D013160:Splenic Neoplasms / Q000175:diagnosis / Q000209:etiology*