title: Efficient induction of specific cytotoxic T lymphocytes against gastric adenocarcinoma by a survivin peptide.
abstract: Survivin has been demonstrated to be an excellent target for immunotherapy in several types of cancer, but little is known of the efficacy of survivin with gastric adenocarcinoma. In this study, a simple method was performed, and relatively high efficacy was shown upon inducing survivin-derived peptide-specific cytotoxic T lymphocytes (CTL) from peripheral blood mononuclear cells of healthy donors. The induced CTLs exhibited specific lysisagainstHLA-A2 matched tumor cells in vitro, and similar results were demonstrated in primary cell cultures isolated from patients with gastric adenocarcinoma. Up to 30% of randomly selected patients could potentially benefit from immunotherapy targeting survivin. These results suggested that this survivin epitope peptide could be a promising vaccine candidate for immunotherapy for patients with gastric adenocarcinoma.
authors.affiliation: State Key Laboratory of Cancer Biology & Institute of Digestive Diseases, Xijing Hospital, the Fourth Military Medical University, 17 Changle Western Road, Xi'an, Shaanxi Province 710032, PR China.
authors.forename: Yi
authors.initials: Y
authors.lastname: Gang
authors.forename: Xiaoyin
authors.initials: X
authors.lastname: Zhang
authors.forename: Yuanlong
authors.initials: Y
authors.lastname: He
authors.forename: Jianyong
authors.initials: J
authors.lastname: Zheng
authors.forename: Kaichun
authors.initials: K
authors.lastname: Wu
authors.forename: Jie
authors.initials: J
authors.lastname: Ding
authors.forename: Daiming
authors.initials: D
authors.lastname: Fan
mesh_terms: D000230:Adenocarcinoma / Q000276:immunology* / Q000473:pathology; D000328:Adult; D000368:Aged; D000951:Antigens, Neoplasm / Q000276:immunology; D045744:Cell Line, Tumor; D003602:Cytotoxicity, Immunologic; D005260:Female; D015789:HLA-A2 Antigen / Q000276:immunology*; D006801:Humans; D051034:Inhibitor of Apoptosis Proteins / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D010446:Peptide Fragments / Q000276:immunology*; D013274:Stomach Neoplasms / Q000276:immunology* / Q000473:pathology; D000077022:Survivin; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology*
chemical_list: D000951:Antigens, Neoplasm; C107489:BIRC5 protein, human; D015789:HLA-A2 Antigen; D051034:Inhibitor of Apoptosis Proteins; D010446:Peptide Fragments; D000077022:Survivin