title: [Expression and clinical significance of P-gp in colonic gland of chronic schistosomiasis patients].
abstract: OBJECTIVE
  To study the expression of P-glycoprotein (P-gp) in patients with chronic schistosomiasis and its relationship with gender and age, and to explore its clinical significance.
  
  
  METHODS
  The colonic mucosa specimens of 50 chronic schistosomiasis patients and 4 persons who had a family history of colon cancer but their physical examinations were normal (as a control group) were selected and the expressions of P-gp in the colonic gland of these samples were detected with the immunohistochemical staining method.
  
  
  RESULTS
  Compared with the control group, the mean gray value of the positive particles of P-gp of colonic epithelial cells of the chronic schistosomiasis group was significantly reduced (P < 0.05), but positive unit values were significantly increased (P < 0.05), which meant the P-gp expression in colonic gland of the patients with chronic schistosomiasis was significantly increased, but this increase had no relationship with sex and age.
  
  
  CONCLUSIONS
  Chronic schistosomiasis may induce the increase of P-gp expression which may be a compensatory protection mechanism due to the stimulation of schistosome eggs to the colon tissues.
authors.affiliation: First Clinical College, Kunming Medical University, Kunming 650031, China.
authors.forename: Lin-Sen
authors.initials: LS
authors.lastname: Feng
authors.forename: Yan-Ping
authors.initials: YP
authors.lastname: Duan
authors.forename: Ze-Sheng
authors.initials: ZS
authors.lastname: Wu
authors.forename: Jing-Juan
authors.initials: JJ
authors.lastname: Li
authors.forename: Jiao
authors.initials: J
authors.lastname: Wu
authors.forename: Ai-Fen
authors.initials: AF
authors.lastname: Zhang
authors.forename: Dong-Kui
authors.initials: DK
authors.lastname: Zhang
authors.forename: Jin-De
authors.initials: JD
authors.lastname: Wang
mesh_terms: D018435:ATP Binding Cassette Transporter, Subfamily B / Q000378:metabolism*; D000293:Adolescent; D000328:Adult; D000368:Aged; D016022:Case-Control Studies; D003106:Colon / Q000378:metabolism* / Q000469:parasitology; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D007413:Intestinal Mucosa / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D012552:Schistosomiasis / Q000378:metabolism*; D055815:Young Adult
chemical_list: D018435:ATP Binding Cassette Transporter, Subfamily B