title: Nanostructured thin film polymer devices for constant-rate protein delivery.
abstract: Herein long-term delivery of proteins from biodegradable thin film devices is demonstrated, where a nanostructured polymer membrane controls release. Protein was sealed between two poly(caprolactone) films, which generated the thin film devices. Protein release for 210 days was shown in vitro, and stable activity was established through 70 days with a model protein. These thin film devices present a promising delivery platform for biologic therapeutics, particularly for application in constrained spaces.
authors.affiliation: Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, San Francisco, California 94158, USA.
authors.forename: Daniel A
authors.initials: DA
authors.lastname: Bernards
authors.forename: Kevin D
authors.initials: KD
authors.lastname: Lance
authors.forename: Natalie A
authors.initials: NA
authors.lastname: Ciaccio
authors.forename: Tejal A
authors.initials: TA
authors.lastname: Desai
mesh_terms: D001672:Biocompatible Materials / Q000008:administration & dosage / Q000737:chemistry; D003692:Delayed-Action Preparations; D016503:Drug Delivery Systems / Q000295:instrumentation; D008855:Microscopy, Electron, Scanning; D058608:Nanopores / Q000648:ultrastructure; D049329:Nanostructures / Q000008:administration & dosage* / Q000737:chemistry / Q000648:ultrastructure*; D036103:Nanotechnology; D011091:Polyesters / Q000737:chemistry; D016062:Porosity; D011506:Proteins / Q000008:administration & dosage*
chemical_list: D001672:Biocompatible Materials; D003692:Delayed-Action Preparations; D011091:Polyesters; D011506:Proteins; C016240:polycaprolactone