title: Single high-dose oral vitamin D3 (stoss) therapy--a solution to vitamin D deficiency in children with cystic fibrosis?
abstract: OBJECTIVE
  To determine the safety and efficacy of stoss therapy on vitamin D levels over a 12 month period in children with cystic fibrosis and vitamin D deficiency (<75 nmol/L).
  
  
  METHODS
  Retrospective chart review of 142 paediatric CF patients from 2007 till 2011.
  
  
  RESULTS
  Thirty eight children received stoss therapy and 37 children with vitamin D deficiency were not treated and served as a control group. The stoss treated group had a significant and sustained increase in 25-hydroxyvitamin D levels measured at 1, 3, 6 and 12 months post treatment compared to controls (94.82 ± 41.0 nmol/L, p=0.001; 81.54 ± 24.6 nmol/L, p=0.001; 92.18 ± 36.5 nmol/L, p=0.008 and 64.6 ± 20.0 nmol/L, p=0.006 respectively). At 12 months post intervention, the mean difference in vitamin D levels from baseline between the stoss treated group and controls was significant at 15 nmol/L compared to 5 nmol/L (p=0.038).
  
  
  CONCLUSIONS
  Stoss therapy effectively achieves and maintains levels of 25-hydroxyvitamin D greater than 75 nmol/L over 12 months.
authors.affiliation: Sydney Children's Hospital, High Street, Randwick, NSW 2031, Australia. Electronic address: Darren.Shepherd@sesiahs.health.nsw.gov.au.
authors.forename: Darren
authors.initials: D
authors.lastname: Shepherd
authors.affiliation: Sydney Children's Hospital, High Street, Randwick, NSW 2031, Australia.
authors.forename: Yvonne
authors.initials: Y
authors.lastname: Belessis
authors.affiliation: Sydney Children's Hospital, High Street, Randwick, NSW 2031, Australia.
authors.forename: Tamarah
authors.initials: T
authors.lastname: Katz
authors.affiliation: Sydney Children's Hospital, High Street, Randwick, NSW 2031, Australia.
authors.forename: John
authors.initials: J
authors.lastname: Morton
authors.affiliation: Sydney Children's Hospital, High Street, Randwick, NSW 2031, Australia.
authors.forename: Penny
authors.initials: P
authors.lastname: Field
authors.affiliation: Sydney Children's Hospital, High Street, Randwick, NSW 2031, Australia.
authors.forename: Adam
authors.initials: A
authors.lastname: Jaffe
mesh_terms: D000284:Administration, Oral; D016022:Case-Control Studies; D002648:Child; D002762:Cholecalciferol / Q000008:administration & dosage / Q000627:therapeutic use*; D003550:Cystic Fibrosis / Q000150:complications*; D005260:Female; D006801:Humans; D008297:Male; D012189:Retrospective Studies; D016896:Treatment Outcome; D014808:Vitamin D Deficiency / Q000188:drug therapy* / Q000209:etiology*
chemical_list: D002762:Cholecalciferol