title: Genome-wide association study identifies a common variant in RAD51B associated with male breast cancer risk.
abstract: We conducted a genome-wide association study of male breast cancer comprising 823 cases and 2,795 controls of European ancestry, with validation in independent sample sets totaling 438 cases and 474 controls. A SNP in RAD51B at 14q24.1 was significantly associated with male breast cancer risk (P = 3.02 × 10(-13); odds ratio (OR) = 1.57). We also refine association at 16q12.1 to a SNP within TOX3 (P = 3.87 × 10(-15); OR = 1.50).
authors.affiliation: The Breakthrough Breast Cancer Research Centre, The Institute of Cancer Research, London, UK. nicholas.orr@icr.ac.uk
authors.forename: Nick
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authors.lastname: Orr
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authors.lastname: Lemnrau
authors.forename: Rosie
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authors.lastname: Cooke
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authors.lastname: Fletcher
authors.forename: Katarzyna
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authors.lastname: Tomczyk
authors.forename: Michael
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authors.lastname: Jones
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authors.lastname: Johnson
authors.forename: Christopher J
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authors.lastname: Mitsopoulos
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authors.forename: Simon S
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authors.lastname: McDade
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authors.lastname: Buck
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authors.lastname: Blancher
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authors.lastname: Trainer
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authors.lastname: Bojesen
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authors.lastname: Bokmand
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authors.lastname: Nevanlinna
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authors.lastname: Mattson
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authors.lastname: Friedman
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authors.lastname: Laitman
authors.forename: Domenico
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authors.lastname: Palli
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authors.lastname: Masala
authors.forename: Ines
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authors.lastname: Ottini
authors.forename: Giuseppe
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authors.lastname: Giannini
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authors.lastname: Hollestelle
authors.forename: Ans M W van den
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authors.lastname: Ouweland
authors.forename: Srdjan
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authors.lastname: Novaković
authors.forename: Mateja
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authors.lastname: Krajc
authors.forename: Manuela
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authors.lastname: Gago-Dominguez
authors.forename: Jose Esteban
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authors.lastname: Castelao
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authors.lastname: Olsson
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authors.lastname: Hedenfalk
authors.forename: Douglas F
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authors.lastname: Easton
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authors.lastname: Pharoah
authors.forename: Alison M
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authors.lastname: Dunning
authors.forename: D Timothy
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authors.lastname: Bishop
authors.forename: Susan L
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authors.lastname: Neuhausen
authors.forename: Linda
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authors.lastname: Steele
authors.forename: Richard S
authors.initials: RS
authors.lastname: Houlston
authors.forename: Montserrat
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authors.lastname: Garcia-Closas
authors.forename: Alan
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authors.lastname: Ashworth
authors.forename: Anthony J
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authors.lastname: Swerdlow
mesh_terms: D018567:Breast Neoplasms, Male / Q000235:genetics*; D002883:Chromosomes, Human, Pair 14; D004268:DNA-Binding Proteins / Q000235:genetics*; D020022:Genetic Predisposition to Disease; D055106:Genome-Wide Association Study; D006801:Humans; D008297:Male; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors; D044465:White People
chemical_list: D004268:DNA-Binding Proteins; C413002:RAD51B protein, human