title: Entry and replication of recombinant hepatitis C viruses in cell culture.
abstract: Hepatitis C virus (HCV) is a positive-strand enveloped RNA virus and belongs to the Flaviviridae family. The heavy health burden associated with the virus infection in humans and the intriguing peculiarities of the interaction between the HCV replication cycle and the hepatocyte host cell have stimulated a flourishing research field. The present review aims at recapitulating the different viral and cellular systems modelling HCV entry and replication, and in particular at gathering the tools available to dissect the HCV entry pathway.
authors.affiliation: Institute of Experimental Virology, TWINCORE, Centre for Experimental and Clinical Infection Research; A Joint Venture Between The Medical School Hannover and The Helmholtz Centre for Infection Research, Feodor-Lynen-Straße 7-9, 30625 Hannover, Germany.
authors.forename: Gabrielle
authors.initials: G
authors.lastname: Vieyres
authors.forename: Thomas
authors.initials: T
authors.lastname: Pietschmann
mesh_terms: D000818:Animals; D018929:Cell Culture Techniques; D016174:Hepacivirus / Q000502:physiology*; D006801:Humans; D011994:Recombinant Proteins / Q000235:genetics / Q000378:metabolism; D053586:Virus Internalization; D014779:Virus Replication / Q000235:genetics / Q000502:physiology*
chemical_list: D011994:Recombinant Proteins