title: Pseudogenes: newly discovered players in human cancer.
abstract: Because they are generally noncoding and thus considered nonfunctional and unimportant, pseudogenes have long been neglected. Recent advances have established that the DNA of a pseudogene, the RNA transcribed from a pseudogene, or the protein translated from a pseudogene can have multiple, diverse functions and that these functions can affect not only their parental genes but also unrelated genes. Therefore, pseudogenes have emerged as a previously unappreciated class of sophisticated modulators of gene expression, with a multifaceted involvement in the pathogenesis of human cancer.
authors.affiliation: Oncogenomics Unit, Core Research Laboratory, Istituto Toscano Tumori (CRL-ITT), c/o IFC-CNR Via Moruzzi 1, 56124 Pisa, Italy. laura.poliseno@gmail.com
authors.forename: Laura
authors.initials: L
authors.lastname: Poliseno
mesh_terms: D004273:DNA, Neoplasm / Q000378:metabolism*; D052138:Genes, Neoplasm; D006801:Humans; D009363:Neoplasm Proteins / Q000096:biosynthesis*; D009369:Neoplasms / Q000378:metabolism*; D014176:Protein Biosynthesis; D011544:Pseudogenes; D012334:RNA, Neoplasm / Q000096:biosynthesis*; D014158:Transcription, Genetic
chemical_list: D004273:DNA, Neoplasm; D009363:Neoplasm Proteins; D012334:RNA, Neoplasm