title: [Clinical value of seminal paraoxonase-1 activity evaluation in the diagnosis of male infertility].
abstract: OBJECTIVE
  To investigate the changes in seminal paraoxonase-1 (PON-1) activity in infertile male patients and assess the clinical value of seminal PON-1 examination in the diagnosis of male infertility.
  
  
  METHODS
  Seminal PON-1 activity was detected by spectrophotometric method in the semen samples from 270 infertile male patients and 50 health fertile males (control), and the semen parameters were analyzed using a computer-assisted semen analysis system.
  
  
  RESULTS
  In the male infertility group, seminal PON-1 activity was 1.22∓0.76 U/L in the patients with normal semen parameters and 0.64∓0.54 in the patients with abnormal semen parameters, both significantly lower than that of the control group (3.17∓0.89 U/L, P<0.01). In patients with asthenospermia, the declined sperm motility was associated with decreased seminal PON-1 activity, which showed significant differences between patients with mild, moderate, and severe asthenospermia. Seminal PON-1 activity was positively correlated with the percentage of sperm viability (P<0.01), but inversely with the percentage of morphologically abnormal sperm (P<0.01). According to ROC curves, the area of seminal PON-1 activity under the curve was 0.907, showing a statistical significance (P<0.01).
  
  
  CONCLUSIONS
  The detection of seminal PON-1 activity can provide a laboratory evidence for the diagnosis of male infertility.
authors.affiliation: Medical College of Foshan University of Science and Technology, Foshan 528000, China. gdy2814687@21cn.com
authors.forename: Daoyuan
authors.initials: D
authors.lastname: Gong
authors.forename: Ziping
authors.initials: Z
authors.lastname: Li
authors.forename: Xiwei
authors.initials: X
authors.lastname: Zhuang
authors.forename: Xiaolin
authors.initials: X
authors.lastname: Zhang
authors.forename: Mei
authors.initials: M
authors.lastname: Kang
authors.forename: Yiping
authors.initials: Y
authors.lastname: Liao
mesh_terms: D000328:Adult; D043303:Aryldialkylphosphatase / Q000378:metabolism*; D016022:Case-Control Studies; D006801:Humans; D007248:Infertility, Male / Q000175:diagnosis / Q000378:metabolism*; D008297:Male; D012661:Semen / Q000378:metabolism*; D055101:Semen Analysis; D055815:Young Adult
chemical_list: D043303:Aryldialkylphosphatase