title: Pretransplant iron overload may be associated with increased risk of invasive fungal pneumonia (IFP) in patients that underwent allogeneic hematopoietic stem cell transplantation (alloHSCT).
abstract: Invasive fungal pneumonia (IFP) has become increasingly common in patients that previously underwent alloHSCT. The aim of this study was to determine the role of hyperferritinemia, via iron overload in invasive fungal pneumonia in patients that underwent alloHSCT. Medical records of 73 patients with pneumonia that underwent alloHSCT were studied retrospectively, whereby a pre-transplantation serum ferritin level measured up to 100 days prior to transplantation of patients with invasive fungal pneumonia (IFP) and non-fungal pneumonia (non-IFP) was compared. Patient records revealed 35 and 38 cases of IFP and non-IFP, respectively. In risk evaluation for IFP, age, gender, HLA status, conditioning regimen, smoking history, and underlying disease were not significantly different among groups (p>0.05). However, performance status (Karnofsky) was significantly lower in patients with IFP (p<0.05). The median ferritin levels were 1,705 ng/ml (41-7198) in the IFP group and 845 ng/ml (18-7099) in non-IFP group and the difference was found statistically significant (p=0.001). Elevated pretransplant serum ferritin level is associated with IFP in patients that underwent alloHSCT, in particular when values exceed 1550 ng/ml.
authors.affiliation: Dedeman Stem Cell Transplantation Hospital, Department of Hematology, Faculty of Medicine, Erciyes University, Kayseri, Turkey. serdarsvgn@gmail.com
authors.forename: Serdar
authors.initials: S
authors.lastname: Sivgin
authors.forename: Süleyman
authors.initials: S
authors.lastname: Baldane
authors.forename: Leylagul
authors.initials: L
authors.lastname: Kaynar
authors.forename: Fatih
authors.initials: F
authors.lastname: Kurnaz
authors.forename: Cigdem
authors.initials: C
authors.lastname: Pala
authors.forename: Hulya
authors.initials: H
authors.lastname: Sivgin
authors.forename: Muzaffer
authors.initials: M
authors.lastname: Keklik
authors.forename: Hayati
authors.initials: H
authors.lastname: Demiraslan
authors.forename: Mustafa
authors.initials: M
authors.lastname: Cetin
authors.forename: Bulent
authors.initials: B
authors.lastname: Eser
authors.forename: Ali
authors.initials: A
authors.lastname: Unal
mesh_terms: D000293:Adolescent; D000328:Adult; D005260:Female; D018380:Hematopoietic Stem Cell Transplantation / Q000009:adverse effects* / Q000379:methods; D006801:Humans; D019190:Iron Overload / Q000097:blood / Q000209:etiology* / Q000382:microbiology; D008172:Lung Diseases, Fungal / Q000097:blood* / Q000175:diagnosis / Q000382:microbiology; D008297:Male; D008875:Middle Aged; D011014:Pneumonia / Q000097:blood* / Q000382:microbiology; D012189:Retrospective Studies; D012307:Risk Factors; D014184:Transplantation, Homologous; D055815:Young Adult