title: [Evaluating the effectiveness and timing of modification of anti-cancer drug therapies for colorectal cancer].
abstract: Although treatments for unresectable colorectal cancer have made great progress with new anticancer agents, they are still unsatisfactory. Development of anti-cancer therapy and its management are important in order to improve the treatment outcome of colorectal cancer. In the evaluation of treatment effect, obtaining a baseline image at the start of treatment is very important, and CT scan is generally performed for this purpose. In daily clinical practice, response evaluation criteria in solid tumors(RECIST)is usually adapted for the assessment of treatment outcomes. In addition, we should make decisions about continued therapy on the basis of both objective and symptomatic findings. Patients receiving palliative chemotherapy should be monitored with a CT scan every 2 to 3 months. It is important to make a treatment strategy individually in consideration of adverse events, purposes of the treatment, and tumor progression.
authors.affiliation: Dept. of Gastroenterological Surgery, Graduate School of Medical Science, Kumamoto University, Japan.
authors.forename: Yuji
authors.initials: Y
authors.lastname: Miyamoto
authors.forename: Yasuo
authors.initials: Y
authors.lastname: Sakamoto
authors.forename: Nobuyuki
authors.initials: N
authors.lastname: Ozaki
authors.forename: Takatsugu
authors.initials: T
authors.lastname: Ishimoto
authors.forename: Masaaki
authors.initials: M
authors.lastname: Iwatsuki
authors.forename: Yoshifumi
authors.initials: Y
authors.lastname: Baba
authors.forename: Shiro
authors.initials: S
authors.lastname: Iwagami
authors.forename: Naoya
authors.initials: N
authors.lastname: Yoshida
authors.forename: Masayuki
authors.initials: M
authors.lastname: Watanabe
authors.forename: Hideo
authors.initials: H
authors.lastname: Baba
mesh_terms: D000970:Antineoplastic Agents / Q000009:adverse effects / Q000627:therapeutic use*; D015179:Colorectal Neoplasms / Q000175:diagnosis / Q000188:drug therapy*; D018450:Disease Progression; D006801:Humans; D017410:Practice Guidelines as Topic; D016896:Treatment Outcome
chemical_list: D000970:Antineoplastic Agents