title: Hyaluronan, a ready choice to fuel regeneration: a mini-review.
abstract: BACKGROUND
  Hyaluronan (HA) is present in extracellular spaces and interstitia of many tissue types. As it is capable of binding high amounts of water, HA provides ideal conditions for cell migration and proliferation. Under conditions of cellular crowding, it also permits lineage-specific differentiation and thus promotes many aspects of healing and tissue remodeling.
  
  
  METHODS
  The simplicity of its structure makes it amenable to chemical modifications and/or combined formulations with other bioactive substances. Thus a wide variety of clinical applications have been proposed, several of which are currently being implemented in advanced therapies.
  
  
  RESULTS
  Known features of HA biology, in particular regarding synthesis and processes related to signaling and control, have been adopted to elaborate specific products in order to support progress in regenerative medicine. Purified HA, HA-based hydrogels or special HA composites have been formulated together with other well-characterized biomaterials and bioactive factors. HA is currently employed in a variety of therapeutic applications both in its pure form and in a biofunctionalized form.
  
  
  CONCLUSIONS
  HA plays an essential role in regenerative processes. Owing to the growing scientific knowledge in this field, medicinal products based on HA have been devised and are being routinely applied in ophthalmology or in trauma and transplantation surgery. Further areas of application are contemplated, such as the use of HA composite scaffold material in tissue engineering, or refined HA hydrogels enabling controlled release of medication.
authors.affiliation: Institute for Biomedical Aging Research, Austrian Academy of Sciences, Innsbruck, Austria. guenter.lepperdinger@oeaw.ac.at
authors.forename: Stephan
authors.initials: S
authors.lastname: Reitinger
authors.forename: Günter
authors.initials: G
authors.lastname: Lepperdinger
mesh_terms: D001672:Biocompatible Materials / Q000737:chemistry; D006801:Humans; D006820:Hyaluronic Acid / Q000737:chemistry* / Q000502:physiology; D044968:Regenerative Medicine / Q000379:methods*; D023822:Tissue Engineering / Q000379:methods*; D014945:Wound Healing / Q000187:drug effects / Q000502:physiology*
chemical_list: D001672:Biocompatible Materials; D006820:Hyaluronic Acid