title: [Impact of obstructive sleep apnea-hypopnea syndrome on cerebral microbleeds in patients with cerebral infarction].
abstract: OBJECTIVE
  To investigate the impact of obstructive sleep apnea-hypopnea syndrome (OSAHS) on cerebral microbleeds (CMBs) in patients with cerebral infarction.
  
  
  METHODS
  Consecutive patients with acute cerebral infarction who had cerebral microbleeds shown by susceptibility-weighted imaging (SWI) were enrolled to undergo polysomnography (PSG). The patients were divided into two groups, namely non-OSAHS group with apnea-hypopnea index (AHI) less than 5 and OSAHS group with greater AHI, and the clinical and radiological features of cerebral microbleeds were compared between them.
  
  
  RESULTS
  Forty-nine patients were enrolled in this study, including 27 (55.1%) with both cerebral infarction and OSAHS and 22 (44.9%) with cerebral infarction but not OSAHS. A comparison of the risk factors showed that hypertension, a smoking history, and a history of stroke were more prevalent in patients with OSAHS than in those without OSAHS (P<0.05). The incidences of subclinical stroke in OSAHS and non-OSAHS patients were 37.0% (10/27) and 9.0% (2/22) (P<0.05), respectively. Neurological imaging revealed a greater number of cerebral microbleeds in OSAHS group than in non-OSAHS group (P<0.05). In OSAHS patients, 77.8% of the microbleeds were distributed in cortical-subcortical areas, 55.6% in the basal ganglia area, and 25.9% in the infratentorial area, as compared to the percentages of 50.0%, 40.9% and 50.0% in non-OSAHS patients, respectively (P<0.05). In OSAHS patients, 40.7% also had leukoaraiosis, and 48.1% had two or more causes, as compared to the percentages of 13.6% and 18.2% in non-OSAHS patients, respectively (P<0.05).
  
  
  CONCLUSIONS
  OSAHS can be a risk factor for cerebral microbleeds. Patients with both cerebral infarction and OSAHS tend to have greater and more extensive lesions of cerebral microbleeds, more complicated cause of the disease, and a grater likeliness of stroke recurrence.
authors.affiliation: Department of Neurology, Second Affiliated Hospital of Nanchang University, Nanchang 330006, China. lqlq1986913@163.com
authors.forename: Jiewen
authors.initials: J
authors.lastname: Xu
authors.forename: Liying
authors.initials: L
authors.lastname: Deng
authors.forename: Xueliang
authors.initials: X
authors.lastname: Zou
authors.forename: Hao
authors.initials: H
authors.lastname: Liu
authors.forename: Ye
authors.initials: Y
authors.lastname: Yu
authors.forename: Yongmin
authors.initials: Y
authors.lastname: Ding
mesh_terms: D000368:Aged; D002543:Cerebral Hemorrhage / Q000209:etiology / Q000473:pathology*; D002544:Cerebral Infarction / Q000473:pathology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012307:Risk Factors; D020181:Sleep Apnea, Obstructive / Q000150:complications / Q000473:pathology*