title: Nasal polyposis in lung transplant recipients with cystic fibrosis.
abstract: BACKGROUND
  Chronic rhinosinusitis with nasal polyposis is common in patients with cystic fibrosis (CF). There are still many open questions regarding factors related to this condition. Furthermore, the prevalence of nasal polyposis and its implications for the outcomes in lung transplant recipients with cystic fibrosis are unknown.
  
  
  METHODS
  All CF patients who underwent lung transplantation at our centre between November 1992 and December 2009 were included. Nasal polyp status was determined endoscopically at time sinus surgery and its relationships to gender, age at lung transplantation, Liou raw score, body mass index, FEV1%predicted, diabetes mellitus, pre-transplant pseudomonas colonisation of the sinuses and the lungs, pre-transplant corticosteroid use and type of mutation of the CFTR gene were analysed. The post-transplant survival times and the incidence of bronchiolitis obliterans syndrome in patients with or without nasal polyposis were compared.
  
  
  RESULTS
  Nasal polyps were found in 19% (17 patients) of the 89 lung transplant recipients, whose data was available for statistical analysis. None of the factors analysed was related to the nasal polyp status. The post-transplant survival times and the incidence of bronchiolitis obliterans syndrome did not significantly differ between patients with or without nasal polyposis.
  
  
  CONCLUSIONS
  CF-related nasal polyposis occurs in a relevant fraction of lung transplant recipients. A specific effect of nasal polyposis on post-transplant outcome could not be confirmed. Nevertheless, there was a trend to NP recurrence in patients with post-transplant sinonasal pseudomonas colonisation and is a tendency of less chronic rejection in CF patients with nasal polyps.
authors.affiliation: Division of Otorhinolaryngology Head and Neck Surgery, University Hospital, Zurich, Switzerland.
authors.forename: Domenic
authors.initials: D
authors.lastname: Vital
authors.forename: David
authors.initials: D
authors.lastname: Holzmann
authors.forename: Annette
authors.initials: A
authors.lastname: Boehler
authors.forename: Markus
authors.initials: M
authors.lastname: Hofer
mesh_terms: D000328:Adult; D001989:Bronchiolitis Obliterans / Q000453:epidemiology / Q000209:etiology; D003550:Cystic Fibrosis / Q000150:complications*; D005260:Female; D006801:Humans; D015994:Incidence; D016040:Lung Transplantation; D008297:Male; D009298:Nasal Polyps / Q000150:complications* / Q000453:epidemiology*; D011183:Postoperative Complications / Q000453:epidemiology / Q000209:etiology; D015995:Prevalence; D012189:Retrospective Studies; D015996:Survival Rate; D055815:Young Adult