title: Cell responses to growth factors: the role of receptor tyrosine kinase intracellular domain fragments.
abstract: Growth factor activation of receptor tyrosine kinases (RTKs) provokes well-described canonical second messenger pathways that transmit biochemical signals in the cytoplasm and to the nucleus to initiate cellular responses. The proteolytic liberation of intracellular domain fragments (ICDs) from activated RTKs and the nuclear translocation of these ICDs represent a more recently identified and noncanonical mechanism by which RTKs communicate with the nucleus. Several reports have added previously unknown facets to the ICD mechanism and have enlarged the scope of ICDs as second messengers.
authors.affiliation: Department of Biochemistry, Vanderbilt University, Nashville, TN 37232, USA. graham.carpenter@vanderbilt.edu
authors.forename: Graham
authors.initials: G
authors.lastname: Carpenter
authors.forename: Ambra
authors.initials: A
authors.lastname: Pozzi
mesh_terms: D002467:Cell Nucleus / Q000378:metabolism*; D004789:Enzyme Activation / Q000502:physiology; D005786:Gene Expression Regulation / Q000502:physiology*; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins / Q000378:metabolism*; D008954:Models, Biological; D010446:Peptide Fragments / Q000378:metabolism*; D020794:Receptor Protein-Tyrosine Kinases / Q000378:metabolism*; D015290:Second Messenger Systems / Q000502:physiology*
chemical_list: D036341:Intercellular Signaling Peptides and Proteins; D010446:Peptide Fragments; D020794:Receptor Protein-Tyrosine Kinases