title: Tired of diabetes genetics? Circadian rhythms and diabetes: the MTNR1B story?
abstract: Circadian rhythms are ubiquitous in biological systems and regulate metabolic processes throughout the body. Misalliance of these circadian rhythms and the systems they regulate has a profound impact on hormone levels and increases risk of developing metabolic diseases. Melatonin, a hormone secreted by the pineal gland, is one of the major signaling molecules used by the master circadian oscillator to entrain downstream circadian rhythms. Several recent genetic studies have pointed out that a common variant in the gene that encodes the melatonin receptor 2 (MTNR1B) is associated with impaired glucose homeostasis, reduced insulin secretion, and an increased risk of developing type 2 diabetes. Here, we try to review the role of this receptor and its signaling pathways in respect to glucose homeostasis and development of the disease.
authors.affiliation: Unit of Molecular Metabolism, Department of Clinical Sciences in Malmoe, Lund University Diabetes Centre, 20502, Malmoe, Sweden. cecilia.nagorny@med.lu.se
authors.forename: Cecilia
authors.initials: C
authors.lastname: Nagorny
authors.forename: Valeriya
authors.initials: V
authors.lastname: Lyssenko
mesh_terms: D002940:Circadian Rhythm / Q000235:genetics*; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000235:genetics*; D005260:Female; D014644:Genetic Variation; D006801:Humans; D007328:Insulin / Q000097:blood* / Q000378:metabolism; D000078790:Insulin Secretion; D050417:Insulin-Secreting Cells; D008297:Male; D008550:Melatonin / Q000096:biosynthesis*; D044122:Receptor, Melatonin, MT1 / Q000097:blood / Q000235:genetics*; D044123:Receptor, Melatonin, MT2 / Q000097:blood / Q000235:genetics*; D012307:Risk Factors; D015398:Signal Transduction
chemical_list: D007328:Insulin; C573871:MTNR1B protein, human; D044122:Receptor, Melatonin, MT1; D044123:Receptor, Melatonin, MT2; D008550:Melatonin