title: New flavones with antidiabetic activity from Callistemon lanceolatus DC.
abstract: Phytochemical investigation of the aerial parts of Callistemon lanceolatus DC (Myrtaceae) led to the isolation of two new flavones characterized as 5,7-dihydroxy-6,8-dimethyl- 4' -methoxy flavone (1) and 8-(2-hydroxypropan-2-yl)-5-hydroxy-7-methoxy-6-methyl-4'-methoxy flavone (2) along with the seven known phytoconstituents. The structures of new compounds have been established on the basis of chemical and spectral studies and known compounds were compared with the published literature data. The isolated flavones exhibited blood glucose lowering effect in streptozotocin induced diabetic rats.
authors.affiliation: Department of Chemistry, Faculty of Science, Jamia Hamdard, Hamdard University, New Delhi-110062, India.
authors.forename: Syed
authors.initials: S
authors.lastname: Nazreen
authors.forename: Gurpreet
authors.initials: G
authors.lastname: Kaur
authors.forename: Mohammad Mahboob
authors.initials: MM
authors.lastname: Alam
authors.forename: Syed
authors.initials: S
authors.lastname: Shafi
authors.forename: Hinna
authors.initials: H
authors.lastname: Hamid
authors.forename: Mohammad
authors.initials: M
authors.lastname: Ali
authors.forename: Mohammad Sarwar
authors.initials: MS
authors.lastname: Alam
mesh_terms: D000818:Animals; D003921:Diabetes Mellitus, Experimental / Q000188:drug therapy*; D047309:Flavones / Q000737:chemistry / Q000494:pharmacology*; D007004:Hypoglycemic Agents / Q000737:chemistry / Q000494:pharmacology*; D015394:Molecular Structure; D027822:Myrtaceae / Q000737:chemistry*; D051381:Rats
chemical_list: C581168:5,7-dihydroxy-6,8-dimethyl-4'-methoxyflavone; C581169:8-(2-hydroxypropan-2-yl)-5-hydroxy-7-methoxy-6-methyl-4'-methoxyflavone; D047309:Flavones; D007004:Hypoglycemic Agents