title: Factors associated with false-positive results from fingerstick OraQuick ADVANCE rapid HIV 1/2 antibody test.
abstract: OBJECTIVE
  Identify factors associated with false-positive rapid HIV antibody tests.
  
  
  METHODS
  This retrospective cohort study with nested case-controls involved patients tested for HIV by Boston Medical Center (BMC) affiliates.
  
  
  METHODS
  Cases had a reactive fingerstick OraQuick ADVANCE rapid HIV 1/2 antibody test and a negative Western blot. Controls had nonreactive rapid tests. We compared the prevalence of HIV risk factors between cases and the total nonreactive population and the prevalence of other clinical factors between cases and controls.
  
  
  RESULTS
  Of the 15 094 tests, 14 937 (98.9%) were negative and 11 (0.07%) were false positives (specificity of 99.9%). Cases were more likely to have had an HIV-infected sex partner and to be tested at certain sites compared to true negatives. More cases than controls had O-negative blood type.
  
  
  CONCLUSIONS
  O-negative blood type and sex with an HIV-infected person may increase false-positive HIV fingerstick results. More targeted studies should examine these risk factors.
authors.affiliation: 1Boston University School of Medicine, Boston, MA, USA.
authors.forename: Samara B
authors.initials: SB
authors.lastname: Rifkin
authors.forename: Lauren E
authors.initials: LE
authors.lastname: Owens
authors.forename: Jeffrey L
authors.initials: JL
authors.lastname: Greenwald
mesh_terms: D000017:ABO Blood-Group System; D000328:Adult; D000914:Antibodies, Viral / Q000097:blood*; D016022:Case-Control Studies; D005189:False Positive Reactions; D005260:Female; D006679:HIV Seropositivity / Q000097:blood / Q000175:diagnosis* / Q000821:virology; D015497:HIV-1 / Q000276:immunology*; D015498:HIV-2 / Q000276:immunology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D012307:Risk Factors; D012725:Sexual Behavior; D055815:Young Adult
chemical_list: D000017:ABO Blood-Group System; D000914:Antibodies, Viral