title: Castleman's Disease: A Case Report of the Unicentric Type.
abstract: Castleman's disease, or angiofollicular lymph node hyperplasia, is a relatively rare disorder characterized by the benign proliferation of lymphoid tissue related to the chronic human herpes virus 8 (HHV-8) infection and the human immunodeficiency virus (HIV). Two clinical entities have been described: a unicentric presentation with the disease confined to a single anatomic lymph node and a multicentric presentation characterized by generalized lymphadenopathy and a more aggressive clinical course. Also, three histopathological subtypes have been described: hyaline-vascular, plasma cell, and a mixed variant. Preoperative diagnosis of hyaline-vascular Castleman's disease is difficult, and the definitive result is based on postoperative pathological findings. The gold standard therapy is the complete surgical excision.
authors.affiliation: Department of General Surgery, La Princesa University Hospital, 62 Diego de Leon Street, 28006 Madrid, Spain.
authors.forename: J
authors.initials: J
authors.lastname: Gomez-Ramirez
authors.forename: M
authors.initials: M
authors.lastname: Posada
authors.forename: L
authors.initials: L
authors.lastname: Sanchez-Urdazpal
authors.forename: E
authors.initials: E
authors.lastname: Martin-Perez
authors.forename: L
authors.initials: L
authors.lastname: Del Campo
authors.forename: I
authors.initials: I
authors.lastname: Garcia
authors.forename: J L
authors.initials: JL
authors.lastname: Martin
authors.forename: E
authors.initials: E
authors.lastname: Larrañaga