title: Rejuvenating sirtuins: the rise of a new family of cancer drug targets.
abstract: Sirtuins are a family of NAD+-dependent enzymes that was proposed to control organismal life span about a decade ago. While such role of sirtuins is now debated, mounting evidence involves these enzymes in numerous physiological processes and disease conditions, including metabolism, nutritional behavior, circadian rhythm, but also inflammation and cancer. SIRT1, SIRT2, SIRT3, SIRT6, and SIRT7 have all been linked to carcinogenesis either as tumor suppressor or as cancer promoting proteins. Here, we review the biological rationale for the search of sirtuin inhibitors and activators for treating cancer and the experimental approaches to their identification.
authors.affiliation: Room 221, Department of Internal Medicine, University of Genoa, V.le Benedetto XV 6, 16132 Genoa, Italy.
authors.forename: Santina
authors.initials: S
authors.lastname: Bruzzone
authors.forename: Marco Daniele
authors.initials: MD
authors.lastname: Parenti
authors.forename: Alessia
authors.initials: A
authors.lastname: Grozio
authors.forename: Alberto
authors.initials: A
authors.lastname: Ballestrero
authors.forename: Inga
authors.initials: I
authors.lastname: Bauer
authors.forename: Alberto
authors.initials: A
authors.lastname: Del Rio
authors.forename: Alessio
authors.initials: A
authors.lastname: Nencioni
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology*; D015195:Drug Design; D055808:Drug Discovery / Q000379:methods; D006801:Humans; D058990:Molecular Targeted Therapy; D009369:Neoplasms / Q000188:drug therapy* / Q000473:pathology; D037761:Sirtuins / Q000187:drug effects* / Q000378:metabolism
chemical_list: D000970:Antineoplastic Agents; D037761:Sirtuins