title: [Useful pharmacologic treatment in impaired social interaction in autism spectrum disorders].
abstract: It is important to note that risperidone solution, intranasal administration of oxytocin, and dietary supplementation with large doses of arachidonic acid added to docosahexaenoic acid (DHA) have been reported to improve impaired social interaction. In addition, atypical antipsychotics aripiprazole and SSRI fluvoxamine were useful in treating some aspects of social relatedness or the core deficits of communication and socialization. The evaluation of treatments for ASD should be directed at neurobiological targets known to be important in the brain's response to abnormal developmental trajectories or toward enhancing plasticity during the highly sensitive period in gene-environment interaction (epigenetic mechanism). Recent epidemiological studies have indicated that at least one in every 100 people has some form of ASD. Environmental chemicals can affect the development of the brain. Further studies will be required to address the effect of environmental chemicals.
authors.affiliation: Research Institute of Pervasive Developmental Disorders, Graduate School of Education, Ashiya University.
authors.forename: Kunio
authors.initials: K
authors.lastname: Yui
mesh_terms: D000280:Administration, Inhalation; D014150:Antipsychotic Agents / Q000627:therapeutic use; D016718:Arachidonic Acid / Q000627:therapeutic use; D000068180:Aripiprazole; D002659:Child Development Disorders, Pervasive / Q000188:drug therapy*; D002675:Child, Preschool; D006801:Humans; D007398:Interpersonal Relations; D010121:Oxytocin / Q000008:administration & dosage; D010879:Piperazines / Q000627:therapeutic use; D015363:Quinolones / Q000627:therapeutic use; D018967:Risperidone / Q000627:therapeutic use
chemical_list: D014150:Antipsychotic Agents; D010879:Piperazines; D015363:Quinolones; D016718:Arachidonic Acid; D010121:Oxytocin; D000068180:Aripiprazole; D018967:Risperidone