title: Preferential utilization of D-lactate by Shewanella oneidensis.
abstract: Shewanella oneidensis couples oxidation of lactate to respiration of many substrates. Here we report that llpR (L-lactate-positive regulator, SO_3460) encodes a positive regulator of L-lactate utilization distinct from previously studied regulators. We also demonstrate D-lactate inhibition of L-lactate utilization in S. oneidensis, resulting in preferential utilization of the D isomer.
authors.affiliation: BioTechnology Institute and Department of Microbiology, University of Minnesota-Twin Cities, St. Paul, Minnesota, USA.
authors.forename: Evan D
authors.initials: ED
authors.lastname: Brutinel
authors.forename: Jeffrey A
authors.initials: JA
authors.lastname: Gralnick
mesh_terms: D015964:Gene Expression Regulation, Bacterial; D015971:Gene Expression Regulation, Enzymologic; D019344:Lactic Acid / Q000737:chemistry* / Q000378:metabolism*; D010084:Oxidation-Reduction; D020592:Shewanella / Q000378:metabolism*; D013237:Stereoisomerism; D014157:Transcription Factors / Q000378:metabolism*
chemical_list: D014157:Transcription Factors; D019344:Lactic Acid