title: Benzopyranones from the endophytic fungus Hyalodendriella sp. Ponipodef12 and their bioactivities.
abstract: The endophytic fungus Hyalodendriella sp. Ponipodef12 was isolated from the hybrid 'Neva' of Populus deltoides Marsh × P. nigra L. In this study, four benzopyranones were isolated from the ethyl acetate extract of Hyalodendriella sp. Ponipodef12, and identified as palmariol B (1), 4-hydroxymellein (2), alternariol 9-methyl ether (3), and botrallin (4) by means of physicochemical and spectroscopic analysis. All the compounds were evaluated for their antibacterial, antifungal, antinematodal and acetylcholinesterase inhibitory activities. 4-Hydroxymellein (2) exhibited stronger antibacterial activity than the other compounds. Palmariol B (1) showed stronger antimicrobial, antinematodal and acetylcholinesterase inhibitory activities than alternariol 9-methyl ether (3) which indicated that the chlorine substitution at position 2 may contribute to its bioactivity. The results indicate the potential of this endophytic fungus as a source of bioactive benzopyranones.
authors.affiliation: College of Agronomy and Biotechnology, China Agricultural University, Beijing 100193, China. lgzhou@cau.edu.cn.
authors.forename: Xiangjie
authors.initials: X
authors.lastname: Meng
authors.forename: Ziling
authors.initials: Z
authors.lastname: Mao
authors.forename: Jingfeng
authors.initials: J
authors.lastname: Lou
authors.forename: Liang
authors.initials: L
authors.lastname: Xu
authors.forename: Lingyun
authors.initials: L
authors.lastname: Zhong
authors.forename: Youliang
authors.initials: Y
authors.lastname: Peng
authors.forename: Ligang
authors.initials: L
authors.lastname: Zhou
authors.forename: Mingan
authors.initials: M
authors.lastname: Wang
mesh_terms: D000818:Animals; D000890:Anti-Infective Agents / Q000737:chemistry* / Q000494:pharmacology*; D000969:Antinematodal Agents / Q000494:pharmacology; D001203:Ascomycota / Q000737:chemistry*; D001578:Benzopyrans / Q000737:chemistry* / Q000494:pharmacology*; D017173:Caenorhabditis elegans / Q000187:drug effects; D002800:Cholinesterase Inhibitors / Q000494:pharmacology; D020128:Inhibitory Concentration 50; D008826:Microbial Sensitivity Tests
chemical_list: D000890:Anti-Infective Agents; D000969:Antinematodal Agents; D001578:Benzopyrans; D002800:Cholinesterase Inhibitors