title: Hyponatraemia in patients with crush syndrome during the Wenchuan earthquake.
abstract: BACKGROUND
  Although sodium disturbances are common in hospitalised patients, no study has specifically investigated the epidemiology of hyponatraemia in patients with crush syndrome.
  
  
  OBJECTIVE
  To describe the incidence of hyponatraemia and assess its effect on outcome in patients with crush syndrome during the Wenchuan earthquake.
  
  
  METHODS
  A retrospective study was conducted in 17 reference hospitals during the Wenchuan earthquake. We excluded patients younger than 15 years and those with missing sodium values within 3 days after being rescued from the ruins.
  
  
  RESULTS
  Hyponatraemia (serum sodium concentration <135 mmol/l) was seen in 91/180 (50.6%) patients on admission. Compared with patients with normonatraemia, those with hyponatraemia were younger, had more severe traumatic injury and renal failure, underwent more fasciotomies, received more blood transfusion and renal replacement therapy. In the multivariable-adjusted model, the number of extremity injuries (OR=1.59, 95% CI 1.08 to 2.33) and serum creatinine (OR=1.30, 95% CI 1.07 to 1.59) were independently associated with the occurrence of hyponatraemia. Covariate adjusted multiple logistic regression analysis showed an independent mortality risk rising with hyponatraemia (OR=5.74, 95% CI 1.18 to 28.00).
  
  
  CONCLUSIONS
  Hyponatraemia was common in the patients with crush syndrome during the Wenchuan earthquake and associated with poor prognosis. Water, commercial drinks and hypotonic intravenous fluids should be supplied carefully to patients with crush syndrome.
authors.affiliation: State Key Laboratory of Kidney Disease, Chinese PLA General Hospital, Beijing, China.
authors.forename: Li
authors.initials: L
authors.lastname: Zhang
authors.forename: Ping
authors.initials: P
authors.lastname: Fu
authors.forename: Li
authors.initials: L
authors.lastname: Wang
authors.forename: Guangyan
authors.initials: G
authors.lastname: Cai
authors.forename: Lin
authors.initials: L
authors.lastname: Zhang
authors.forename: Dezheng
authors.initials: D
authors.lastname: Chen
authors.forename: Dongyang
authors.initials: D
authors.lastname: Guo
authors.forename: Xuefeng
authors.initials: X
authors.lastname: Sun
authors.forename: Fuqiong
authors.initials: F
authors.lastname: Chen
authors.forename: Weihong
authors.initials: W
authors.lastname: Bi
authors.forename: Xinjie
authors.initials: X
authors.lastname: Zeng
authors.forename: Haiyan
authors.initials: H
authors.lastname: Li
authors.forename: Zhaohui
authors.initials: Z
authors.lastname: Liu
authors.forename: Yong
authors.initials: Y
authors.lastname: Wang
authors.forename: Songmin
authors.initials: S
authors.lastname: Huang
authors.forename: Xiangmei
authors.initials: X
authors.lastname: Chen
mesh_terms: D000328:Adult; D002681:China / Q000453:epidemiology; D003404:Creatinine / Q000097:blood; D003444:Crush Syndrome / Q000097:blood / Q000150:complications*; D055866:Earthquakes; D005121:Extremities / Q000293:injuries; D005260:Female; D006801:Humans; D007010:Hyponatremia / Q000097:blood / Q000453:epidemiology* / Q000401:mortality; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D015995:Prevalence; D011379:Prognosis; D012189:Retrospective Studies; D012307:Risk Factors; D014947:Wounds and Injuries / Q000150:complications
chemical_list: D003404:Creatinine