title: Dialysis methods may affect carotid intima-media thickness in Chinese end-stage renal disease patients.
abstract: Atherosclerosis is the most common cause of cardiovascular morbidity in end-stage renal disease (ESRD) patients and carotid intima-media thickness (IMT) is an early independent predictor of atherosclerosis. The aim of this study is to compare the continuous ambulatory peritoneal dialysis (CAPD) and the maintenance hemodialysis (MHD) for carotid IMT in Chinese ESRD patients. A total of 72 CAPD patients, 92 MHD patients, and 50 age- and sex-matched healthy controls were included. Dialysis patients were divided into five subgroups according to dialysis duration: 3-6, 7-12, 13-59, 60-119, and 120-179 months. Carotid IMT and carotid plaques were detected for each patient. The carotid IMT and total plaque detection rate in the CAPD and MHD groups were considerably higher than in the healthy control group (p < 0.01). No significant difference was found in the carotid IMT and total plaque detection rate between the CAPD group and the MHD group (p > 0.05). However, after stratification by dialysis duration, the total carotid IMT in the CAPD subgroup was higher than in the MHD subgroup in dialysis duration of 60-119 and 120-179 months (p < 0.05), and there was no significant difference in the total plaque detection rate between the CAPD and MHD subgroups in the same dialysis duration (p > 0.05). Our study showed that both CAPD and MHD affect carotid IMT in Chinese ESRD patients, and the degree of atherosclerosis in CAPD patients might be higher than that in MHD patients after 5 years of dialysis.
authors.affiliation: Department of Nephrology, The First Affiliated Hospital of Huzhou Teachers College, Huzhou, Zhejiang, PR China.
authors.forename: Zhanqin
authors.initials: Z
authors.lastname: Shi
authors.forename: Ming
authors.initials: M
authors.lastname: Zhu
authors.forename: Jianming
authors.initials: J
authors.lastname: Guan
authors.forename: Jianghua
authors.initials: J
authors.lastname: Chen
authors.forename: Qiang
authors.initials: Q
authors.lastname: He
authors.forename: Xiaohui
authors.initials: X
authors.lastname: Zhang
authors.forename: Shaoming
authors.initials: S
authors.lastname: Zhu
authors.forename: Xuequan
authors.initials: X
authors.lastname: Song
authors.forename: Xiaoyi
authors.initials: X
authors.lastname: Wang
authors.forename: Zhiqiang
authors.initials: Z
authors.lastname: Jiang
mesh_terms: D059168:Carotid Intima-Media Thickness; D002681:China; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D007676:Kidney Failure, Chronic / Q000473:pathology* / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D010531:Peritoneal Dialysis, Continuous Ambulatory / Q000009:adverse effects; D006435:Renal Dialysis / Q000009:adverse effects* / Q000379:methods*