title: Association of serum YKL-40 levels with urinary albumin excretion rate in young Japanese patients with type 1 diabetes mellitus.
abstract: YKL-40 is a marker of inflammation and endothelial dysfunction, both of which play important roles in the progression of diabetic complications.  However, little information has been obtained about serum YKL-40 levels in type 1 diabetic patients. We evaluated YKL-40 levels and its association with diabetic micro- and macroandgiopathy in 131 young Japanese type 1 diabetic patients without advanced diabetic complications (aged 24.7±5.9 years) and 97 age- and gender-matched healthy controls.  YKL-40 levels were significantly elevated in type 1 diabetic patients than in healthy controls (median (range) 46.4 (20.3-136.7) and 52.3 (21.4-274.1) ng/mL, respectively, p = 0.003).  There was a significant positive association between YKL-40 levels and urinary albumin creatinine ratio (UACR) (r = 0.226, p = 0.013).  Furthermore, a multivariate regression analysis demonstrated that YKL-40 levels were a determinant of UACR independently of conventional risk factors.  In addition, YKL-40 levels were significantly higher in participants with diabetic retinopathy compared to those without it (median (range) 55.5 (23.3-274.1) and 50.3 (21.4-237.4) ng/mL, respectively, p = 0.039).  Serum YKL-40 levels were elevated in type 1 diabetic patients and associated with increasing level of albuminuria.  YKL-40 could be a predictor to assess the risk of diabetic microangiopathy in the early stage in type 1 diabetic patients.
authors.affiliation: Department of Metabolic Medicine, Osaka University Graduate School of Medicine, Suita 565-0871, Japan.
authors.forename: Fumie
authors.initials: F
authors.lastname: Sakamoto
authors.forename: Naoto
authors.initials: N
authors.lastname: Katakami
authors.forename: Hideaki
authors.initials: H
authors.lastname: Kaneto
authors.forename: Tetsuyuki
authors.initials: T
authors.lastname: Yasuda
authors.forename: Mitsuyoshi
authors.initials: M
authors.lastname: Takahara
authors.forename: Kazuyuki
authors.initials: K
authors.lastname: Miyashita
authors.forename: Akio
authors.initials: A
authors.lastname: Kuroda
authors.forename: Munehide
authors.initials: M
authors.lastname: Matsuhisa
authors.forename: Keisuke
authors.initials: K
authors.lastname: Kosugi
authors.forename: Iichiro
authors.initials: I
authors.lastname: Shimomura
mesh_terms: D054392:Adipokines / Q000097:blood*; D000328:Adult; D000419:Albuminuria / Q000097:blood*; D044466:Asian People; D000071451:Chitinase-3-Like Protein 1; D003922:Diabetes Mellitus, Type 1 / Q000097:blood / Q000378:metabolism* / Q000652:urine; D003925:Diabetic Angiopathies / Q000097:blood / Q000378:metabolism* / Q000652:urine; D003930:Diabetic Retinopathy / Q000097:blood / Q000378:metabolism* / Q000652:urine; D018450:Disease Progression; D005260:Female; D006801:Humans; D037102:Lectins / Q000097:blood*; D008297:Male
chemical_list: D054392:Adipokines; C084533:CHI3L1 protein, human; D000071451:Chitinase-3-Like Protein 1; D037102:Lectins