title: [Adipose tissue renin-angiotensin system in obese].
abstract: Activation of the renin-angiotensin system (RAS) is commonly observed in patients with obesity. Adipose tissue expresses all components of RAS, implicating adipose renin-angiotensin system (A-RAS) in the pathophysiology of obesity. Angiotensin-converting enzyme(ACE) inhibitors and angiotensin II type 1 receptor (AT1R) blockers ameliorate obesity-related metabolic derangement. Of note, CASE-J trial demonstrated that a systemic blockade of RAS significantly reduced the incidence of newly occurring type 2 diabetes, notably in obese patients with hypertension. We reported that adipose tissue-derived AGT is substantially augmented in obesity and may contribute to hypertension in humans, thereby highlighting a pivotal role of A-RAS in systemic RAS activation and resultant metabolic derangement.
authors.affiliation: Division of Endocrinology and Metabolism, National Cerebral and Cardiovascular Center, Kyoto University Hospital.
authors.forename: Shintaro
authors.initials: S
authors.lastname: Yasue
authors.forename: Ken
authors.initials: K
authors.lastname: Ebihara
authors.forename: Kazuwa
authors.initials: K
authors.lastname: Nakao
mesh_terms: D000273:Adipose Tissue / Q000187:drug effects* / Q000378:metabolism; D000806:Angiotensin-Converting Enzyme Inhibitors / Q000627:therapeutic use*; D000809:Angiotensins / Q000378:metabolism; D000818:Animals; D003924:Diabetes Mellitus, Type 2 / Q000378:metabolism / Q000517:prevention & control; D006801:Humans; D009765:Obesity / Q000188:drug therapy* / Q000378:metabolism; D012084:Renin-Angiotensin System / Q000502:physiology*
chemical_list: D000806:Angiotensin-Converting Enzyme Inhibitors; D000809:Angiotensins