title: Fibrin glue for prevention of recurrent epithelial ingrowth under a LASIK flap with a central buttonhole defect.
abstract: A 61-year-old woman presented with a paracentral buttonhole flap defect associated with a linear tear, extensive epithelial ingrowth, and macrostriae in the right eye. A laser in situ keratomileusis enhancement had been performed 3 weeks earlier. The epithelial ingrowth was removed after careful lifting of the flap, and tissue adhesive was used postoperatively as a barrier to further ingrowth. Six months postoperatively, the patient's corrected distance visual acuity had improved to 20/20 and the slitlamp examination showed no evidence of recurrent epithelial ingrowth. This case presents a novel approach to the management of a buttonhole defect.
authors.affiliation: Department of Ophthalmology, Stanford University School of Medicine, Palo Alto, California 94303, USA.
authors.forename: Lingmin
authors.initials: L
authors.lastname: He
authors.forename: Edward E
authors.initials: EE
authors.lastname: Manche
mesh_terms: D057128:Aberrometry; D057112:Corneal Perforation / Q000209:etiology / Q000473:pathology / Q000517:prevention & control*; D003319:Corneal Stroma / Q000473:pathology; D019781:Corneal Topography; D019573:Epithelium, Corneal / Q000473:pathology*; D005260:Female; D015718:Fibrin Tissue Adhesive / Q000627:therapeutic use*; D006801:Humans; D020731:Keratomileusis, Laser In Situ / Q000009:adverse effects*; D008875:Middle Aged; D055502:Secondary Prevention; D013524:Surgical Flaps / Q000473:pathology*; D014014:Tissue Adhesives / Q000627:therapeutic use*; D014792:Visual Acuity
chemical_list: D015718:Fibrin Tissue Adhesive; D014014:Tissue Adhesives