title: Leptin deficiency modulates allograft survival by favoring a Th2 and a regulatory immune profile. [corrected].
abstract: Leptin, an adipose-secreted hormone, links metabolism and immunity. Our aim was to determine whether leptin affects the alloimmune response. We used an allogeneic skin transplant model as a means to analyze the allograft immune response in Lep(ob/ob) and wild-type mice. Leptin deficiency results in an increased frequency of Treg and Th2 cells and a prolonged graft survival. These effects of leptin deficiency indicate the importance of leptin and obesity in modulating the allograft immune responses. Our data suggest a possible explanation for the increased susceptibility of hyperleptinemic obese patients to acute and chronic graft rejection.
authors.affiliation: Department of Immunology, Institute of Biomedical Sciences, University of São Paulo, Brazil.
authors.forename: P M M
authors.initials: PM
authors.lastname: Moraes-Vieira
authors.forename: E J
authors.initials: EJ
authors.lastname: Bassi
authors.forename: R A
authors.initials: RA
authors.lastname: Larocca
authors.forename: A
authors.initials: A
authors.lastname: Castoldi
authors.forename: M
authors.initials: M
authors.lastname: Burghos
authors.forename: A P
authors.initials: AP
authors.lastname: Lepique
authors.forename: F J
authors.initials: FJ
authors.lastname: Quintana
authors.forename: R C
authors.initials: RC
authors.lastname: Araujo
authors.forename: A S
authors.initials: AS
authors.lastname: Basso
authors.forename: T B
authors.initials: TB
authors.lastname: Strom
authors.forename: N O S
authors.initials: NO
authors.lastname: Câmara
mesh_terms: D000818:Animals; D005434:Flow Cytometry; D006085:Graft Survival / Q000502:physiology*; D020738:Leptin / Q000502:physiology*; D007959:Lymphocyte Culture Test, Mixed; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D016133:Polymerase Chain Reaction; D018418:Th2 Cells / Q000276:immunology*; D014184:Transplantation, Homologous
chemical_list: D020738:Leptin