title: Delineating breast ductal carcinoma using combined dye-enhanced wide-field polarization imaging and optical coherence tomography.
abstract: Intra-operative delineation of breast cancer is a challenging problem. We used dye-enhanced wide-field polarization imaging for rapid demarcation of en face cancer margins and optical coherence tomography (OCT) for cross-sectional evaluation. Ductal carcinoma specimens were stained with methylene blue. Wide-field reflectance images were acquired at 440 and 640 nm. Wide-field fluorescence images were excited at 640 nm and registered between 660 nm and 750 nm. OCT images were acquired using a 1310 nm swept-source system. The results were validated against histopathology. Both imaging modalities provided diagnostic information on cancer margins. Combined OCT and wide-field polarization imaging shows promise for intra-operative detection of ductal breast carcinoma.
authors.affiliation: University of Massachusetts, Lowell, 1 University Ave., OL122, Lowell, MA 01854, USA.
authors.forename: Rakesh
authors.initials: R
authors.lastname: Patel
authors.forename: Ashraf
authors.initials: A
authors.lastname: Khan
authors.forename: Michal
authors.initials: M
authors.lastname: Kamionek
authors.forename: Dina
authors.initials: D
authors.lastname: Kandil
authors.forename: Robert
authors.initials: R
authors.lastname: Quinlan
authors.forename: Anna N
authors.initials: AN
authors.lastname: Yaroslavsky
mesh_terms: D000328:Adult; D000368:Aged; D018270:Carcinoma, Ductal, Breast / Q000175:diagnosis* / Q000473:pathology* / Q000601:surgery; D004396:Coloring Agents / Q000378:metabolism*; D005260:Female; D006801:Humans; D007432:Intraoperative Period; D008875:Middle Aged; D057054:Molecular Imaging; D041623:Tomography, Optical Coherence
chemical_list: D004396:Coloring Agents