title: Contribution of myeloid cell subsets to liver fibrosis in parasite infection.
abstract: Accumulation of extracellular matrix components secreted by fibroblasts is a normal feature of wound healing during acute inflammation. However, during most chronic/persistent inflammatory diseases, this tissue repair mechanism is incorrectly regulated and results in irreversible fibrosis in various organs. Fibrosis that severely affects tissue architecture and can cause organ failure is a major cause of death in developed countries. Organ-recruited lymphoid (mainly T cells) and myeloid cells (eosinophils, basophils, macrophages and DCs) have long been recognized in their participation to the development of fibrosis. In particular, a central role for recruited monocyte-derived macrophages in this excessive connective tissue deposit is more and more appreciated. Moreover, the polarization of monocyte-derived macrophages in classically activated (IFNγ-dependent) M1 cells or alternatively activated (IL-4/IL-13) M2 cells, that mirrors the Th1/Th2 polarization of T cells, is also documented to contribute differentially to the fibrotic process. Here, we review the current understanding of how myeloid cell subpopulations affect the development of fibrosis in parasite infections.
authors.affiliation: Myeloid Cell Immunology Laboratory, VIB, Brussels, Belgium. abeschin@vub.ac.be
authors.forename: Alain
authors.initials: A
authors.lastname: Beschin
authors.forename: Patrick
authors.initials: P
authors.lastname: De Baetselier
authors.forename: Jo A
authors.initials: JA
authors.lastname: Van Ginderachter
mesh_terms: D000818:Animals; D004444:Echinococcosis, Hepatic / Q000276:immunology / Q000469:parasitology / Q000473:pathology; D005109:Extracellular Matrix / Q000378:metabolism / Q000469:parasitology / Q000473:pathology; D006801:Humans; D018836:Inflammation Mediators / Q000378:metabolism; D008099:Liver / Q000276:immunology / Q000378:metabolism / Q000469:parasitology* / Q000473:pathology; D008103:Liver Cirrhosis / Q000276:immunology / Q000469:parasitology* / Q000473:pathology; D008109:Liver Diseases, Parasitic / Q000276:immunology / Q000378:metabolism / Q000469:parasitology* / Q000473:pathology; D022423:Myeloid Cells / Q000276:immunology / Q000378:metabolism / Q000469:parasitology* / Q000473:pathology; D012552:Schistosomiasis / Q000276:immunology / Q000469:parasitology / Q000473:pathology
chemical_list: D018836:Inflammation Mediators