title: Innate immune responses to Helicobacter pylori infection: an overview.
abstract: Innate immune receptors detect Helicobacter pylori infection and trigger downstream signaling events that result in the production of cytokines and interferon-β. This chapter gives an overview of the receptors and their roles in responding to H. pylori infection and details the downstream signaling events. The tools that have been developed to study the innate immune response to H. pylori are also discussed. Understanding the immune response to H. pylori is critical to develop better treatments for H. pylori-induced disease states including gastric malignancies and cancer.
authors.affiliation: Division of Infectious Diseases and Immunology, Department of Medicine, University of Massachusetts Medical School, Worcester, MA, USA.
authors.forename: Milan K
authors.initials: MK
authors.lastname: Patel
authors.forename: Melanie I
authors.initials: MI
authors.lastname: Trombly
authors.forename: Evelyn A
authors.initials: EA
authors.lastname: Kurt-Jones
mesh_terms: D000818:Animals; D016481:Helicobacter Infections / Q000276:immunology*; D016480:Helicobacter pylori / Q000276:immunology* / Q000472:pathogenicity; D006801:Humans; D007113:Immunity, Innate