title: Interaction between alcohol consumption and CYP 2C19 gene polymorphism in relation to oesophageal squamous cell carcinoma.
abstract: OBJECTIVE
  The purpose of this study is to explore the relationship between the interactions of CYP2C19 gene polymorphisms and several environmental factors and oesophageal squamous cell carcinoma (OSCC).
  
  
  METHODS
  In a case-control study of OSCC patients (n = 350) and healthy controls (n = 350), we investigated the roles of polymorphism in the CYP2C19 gene by the use of polymerase chain reaction--restriction fragment length polymorphism (PCR - RFLP) analysis.
  
  
  RESULTS
  The CYP2C19(*)3 AG+AA genotype was significantly more prevalent in OSCC patients (10.0% versus 3.43%; P<0.01). Multiple logistic regression analysis showed drinking (OR: 5.603, 95% CI: 3.431-11.112; P = 0.005) and smoking (OR: 4.341, 95% CI: 3.425-10.241; P = 0.001) was the independent risk factor of OSCC respectively, and there were significant interaction between CYP2C19(*)3 and drinking (OR: 8.747, 95% CI: 6.321-18.122; P = 0.009).
  
  
  CONCLUSIONS
  The CYP2C19(*)3 polymorphism and OSCC were synergistically and significantly associated in Chinese Han patients.
authors.affiliation: Department of Chest Surgery; Kunming General Hospital of Chengdu Military Region, Kunming, Yunnan Province, China.
authors.forename: Yun
authors.initials: Y
authors.lastname: Shi
authors.forename: Guo-jun
authors.initials: GJ
authors.lastname: Luo
authors.forename: Li
authors.initials: L
authors.lastname: Zhang
authors.forename: Ji
authors.initials: J
authors.lastname: Shi
authors.forename: Dao-quan
authors.initials: DQ
authors.lastname: Zhang
authors.forename: Jian-min
authors.initials: JM
authors.lastname: Chen
authors.forename: Xiao-bo
authors.initials: XB
authors.lastname: Chen
authors.forename: Zhuo-dong
authors.initials: ZD
authors.lastname: Li
authors.forename: Qing
authors.initials: Q
authors.lastname: Zhao
mesh_terms: D000428:Alcohol Drinking / Q000235:genetics*; D001189:Aryl Hydrocarbon Hydroxylases / Q000235:genetics*; D002294:Carcinoma, Squamous Cell / Q000201:enzymology / Q000235:genetics*; D065731:Cytochrome P-450 CYP2C19; D004938:Esophageal Neoplasms / Q000201:enzymology / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D012307:Risk Factors
chemical_list: D001189:Aryl Hydrocarbon Hydroxylases; C045793:CYP2C19 protein, human; D065731:Cytochrome P-450 CYP2C19