title: [Simultaneous quantitative analysis of four lignanoids in Schisandra chinensis by quantitative analysis of multi-components by single marker].
abstract: The aim of the study is to establish a new method of quality evaluation and validate its feasibilities by the simultaneous quantitative assay of four lignanoids in Schisandra chinensis. A new quality evaluation method, quantitative analysis of multi-components by single marker (QAMS), was established and validated with Schisandra chinensis. Four main lignanoids, schisandrin, schisantherin A, deoxyschizandrin and gamma-schizandrin, were selected as analytes and schisandrin as internal reference substance to evaluate the quality. Their contents in 13 different batches of samples, collected from different bathes, were determined by both external standard method and QAMS. The method was evaluated by comparison of the quantitative results between external standard method and QAMS. No significant differences were found in the quantitative results of four lignanoids in 13 batches of S. chinensis determined by external standard method and QAMS. QAMS is feasible for determination of four lignanoids simultaneously when some authentic standard substances were unavailable, and the developed method can be used for quality control of S. chinensis.
authors.affiliation: Lunan Pharmaceutical Group Co., Ltd., Linyi 276006, China.
authors.forename: Feng-Cheng
authors.initials: FC
authors.lastname: He
authors.forename: Shou-Xin
authors.initials: SX
authors.lastname: Li
authors.forename: Zhi-Quan
authors.initials: ZQ
authors.lastname: Zhao
authors.forename: Jin-Ping
authors.initials: JP
authors.lastname: Dong
authors.forename: Wu-Zhan
authors.initials: WZ
authors.lastname: Liu
authors.forename: Rui-Qiang
authors.initials: RQ
authors.lastname: Su
mesh_terms: D002851:Chromatography, High Pressure Liquid / Q000379:methods; D034242:Cyclooctanes / Q000032:analysis*; D004149:Dioxoles / Q000032:analysis*; D004365:Drugs, Chinese Herbal / Q000737:chemistry; D005638:Fruit / Q000737:chemistry; D017705:Lignans / Q000032:analysis*; D010946:Plants, Medicinal / Q000737:chemistry; D011083:Polycyclic Compounds / Q000032:analysis*; D011786:Quality Control; D032141:Schisandra / Q000737:chemistry*
chemical_list: D034242:Cyclooctanes; D004149:Dioxoles; D004365:Drugs, Chinese Herbal; D017705:Lignans; D011083:Polycyclic Compounds; C015499:schizandrin B; C034734:schizandrin A; C034557:schizandrer A; C011105:schizandrin