title: Porous core/sheath composite nanofibers fabricated by coaxial electrospinning as a potential mat for drug release system.
abstract: This study focused on fabrication and characterization of porous core/sheath structured composite nanofibers with a core of blended salicylic acid (SA) and poly(ethylene glycol) (PEG) and a sheath of poly(lactic acid) (PLA) using a dual-capillary electrospinning system. Results of water contact angle measurements, field-emission scanning electron microscopy, and transmission electron microscopy indicated that feed rates of the core and sheath strongly affect the stability of the core/sheath structure and porous density of the composite nanofibers obtained, significantly influencing their SA release characteristics. At a lower ratio of feed rates of the core and the sheath, better stable core/sheath structures of nanofibers with higher porous density on the surface were formed resulting in a sustained release of SA over 5 days. Non-porous fibers showed a lower amount of drug release because the drug was embedded inside the core layer of the non-porous sheath layer. SA release from porous core/sheath nanofibers was described based on a one-dimensional Fickian diffusion mechanism, indicating that drug diffusion is a predominant factor in drug release. A cytotoxicity test suggested that the porous core/sheath nanofibers are non-toxic and support cell attachment. Therefore, this fiber mat may find application in the design of wound-healing patches with long-term activity.
authors.affiliation: Division of Chemical Engineering, Hankyong National University, 167 Chungang-ro, Anseong-si, Gyeonggi-do 456-749, South Korea.
authors.forename: Thuy Thi Thu
authors.initials: TT
authors.lastname: Nguyen
authors.forename: Chiranjit
authors.initials: C
authors.lastname: Ghosh
authors.forename: Seong-Gu
authors.initials: SG
authors.lastname: Hwang
authors.forename: Noppavan
authors.initials: N
authors.lastname: Chanunpanich
authors.forename: Jun Seo
authors.initials: JS
authors.lastname: Park
mesh_terms: D041721:3T3-L1 Cells; D000818:Animals; D002448:Cell Adhesion / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D002478:Cells, Cultured; D004339:Drug Compounding; D016503:Drug Delivery Systems; D005347:Fibroblasts / Q000187:drug effects; D006801:Humans; D019344:Lactic Acid / Q000737:chemistry / Q000633:toxicity; D051379:Mice; D057139:Nanofibers / Q000737:chemistry* / Q000633:toxicity; D011091:Polyesters; D011092:Polyethylene Glycols / Q000737:chemistry / Q000633:toxicity; D011108:Polymers / Q000737:chemistry / Q000633:toxicity; D016062:Porosity; D020156:Salicylic Acid / Q000737:chemistry / Q000633:toxicity; D013678:Technology, Pharmaceutical
chemical_list: D011091:Polyesters; D011108:Polymers; D019344:Lactic Acid; D011092:Polyethylene Glycols; C033616:poly(lactide); D020156:Salicylic Acid