title: Metastasis from oral cancer: an overview.
abstract: Oral cancer is a common neoplasm worldwide. Its incidence and mortality have also increased over the past decades. It is characterized by poor prognosis and a low survival rate despite sophisticated surgical and radiotherapeutic modalities. Metastasis of oral cancer is a complex process involving detachment of cells from tumor tissue, regulation of cell motility and invasion, proliferation and evasion through the lymphatic system or blood vessels. In this review, we will focus on the current knowledge in metastasis from oral cancer regarding facts, such as incidence; stage, histopathology and grade of primary tumor; clinical manifestations; diagnosis; and treatment. Certainly, such information will contribute to the understanding of oral cancer pathogenesis.
authors.affiliation: Departamento de Biociências, Vila Mathias, Santos - SP, Brazil.
authors.forename: Juliana
authors.initials: J
authors.lastname: Noguti
authors.forename: Carolina Foot Gomes
authors.initials: CF
authors.lastname: De Moura
authors.forename: Gustavo Protasio Pacheco
authors.initials: GP
authors.lastname: De Jesus
authors.forename: Victor Hugo Pereira
authors.initials: VH
authors.lastname: Da Silva
authors.forename: Thais Ayako
authors.initials: TA
authors.lastname: Hossaka
authors.forename: Celina Tijuko Fujiyama
authors.initials: CT
authors.lastname: Oshima
authors.forename: Daniel Araki
authors.initials: DA
authors.lastname: Ribeiro
mesh_terms: D014408:Biomarkers, Tumor / Q000032:analysis; D015820:Cadherins / Q000032:analysis; D002294:Carcinoma, Squamous Cell / Q000188:drug therapy / Q000473:pathology* / Q000601:surgery; D006801:Humans; D007150:Immunohistochemistry / Q000379:methods; D015994:Incidence; D008207:Lymphatic Metastasis / Q000473:pathology*; D009062:Mouth Neoplasms / Q000188:drug therapy / Q000473:pathology* / Q000601:surgery; D060787:Neoplasm Grading / Q000379:methods; D009363:Neoplasm Proteins / Q000032:analysis; D009367:Neoplasm Staging / Q000379:methods; D011379:Prognosis; D012307:Risk Factors
chemical_list: D014408:Biomarkers, Tumor; D015820:Cadherins; D009363:Neoplasm Proteins