title: Riccardin D-26, a synthesized macrocyclic bisbibenzyl compound, inhibits human hepatocellular carcinoma growth through induction of apoptosis in p53-dependent way.
abstract: Riccardin D-26 is a synthesized macrocyclic bisbibenzyl compound. We investigated the effect of Riccardin D-26 on human hepatocellular carcinomas. Riccardin D-26 possessed stronger activity against SMMC-7721 cells than human normal liver cells. Riccardin D-26 injection effectively delayed the growth of SMMC-7721 xenografts in mice without significant toxicity. This effect of Riccardin D-26 was associated with the status of p53 and its targets, bax and p21(Waf1)(/)(Cip1). Riccardin D-26 activated p53 expression and induced cancer cells to apoptosis through the p53-mediated transcription-dependent and -independent pathway. Overall, Riccardin D-26 may inhibit hepatocellular carcinoma growth through induction of apoptosis in p53-dependent pathway.
authors.affiliation: Department of Pharmacology, Key Laboratory of Chemical Biology, School of Pharmaceutical Sciences, Shandong University, China.
authors.forename: Bin
authors.initials: B
authors.lastname: Yue
authors.forename: Yu-Sheng
authors.initials: YS
authors.lastname: Zhang
authors.forename: Hui-Min
authors.initials: HM
authors.lastname: Xu
authors.forename: Cui-Rong
authors.initials: CR
authors.lastname: Zhao
authors.forename: Yuan-Yuan
authors.initials: YY
authors.lastname: Li
authors.forename: Yi-Zhuo
authors.initials: YZ
authors.lastname: Qin
authors.forename: Rui-Qi
authors.initials: RQ
authors.lastname: Wang
authors.forename: Di
authors.initials: D
authors.lastname: Sun
authors.forename: Yi
authors.initials: Y
authors.lastname: Yuan
authors.forename: Hong-Xiang
authors.initials: HX
authors.lastname: Lou
authors.forename: Xian-Jun
authors.initials: XJ
authors.lastname: Qu
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology*; D017209:Apoptosis / Q000187:drug effects*; D006528:Carcinoma, Hepatocellular / Q000188:drug therapy* / Q000378:metabolism; D005260:Female; D006801:Humans; D008113:Liver Neoplasms / Q000188:drug therapy* / Q000378:metabolism; D047028:Macrocyclic Compounds / Q000494:pharmacology*; D051379:Mice; D008807:Mice, Inbred BALB C; D010647:Phenyl Ethers / Q000494:pharmacology*; D013267:Stilbenes / Q000494:pharmacology*; D016159:Tumor Suppressor Protein p53 / Q000378:metabolism*; D023041:Xenograft Model Antitumor Assays
chemical_list: D000970:Antineoplastic Agents; D047028:Macrocyclic Compounds; D010647:Phenyl Ethers; D013267:Stilbenes; D016159:Tumor Suppressor Protein p53; C547185:riccardin D