title: Circular dichroism and anomeric configuration assignment of benzimidazole C-nucleoside analogs.
abstract: The circular dichroism of a series of acyclic polyhydroxyalkyl benzimidazole C-nucleoside analogs was correlated with the stereochemistry of the chiral carbon atom α to the benzimidazole base moiety. This correlation was used for the assignment of the anomeric configuration of 2-(β-L-erythrofuranosyl) benzimidazole C-nucleoside analogs without a need to have the other anomer on hand, in a similar manner to the correlation obtained for assignment of the anomeric configuration of triazole C-nucleoside analogs.
authors.affiliation: Department of Chemistry, Faculty of Science, Alexandria University, Alexandria 21151, Egypt. maesallam@yahoo.com
authors.forename: Mohammed A E
authors.initials: MA
authors.lastname: Sallam
authors.forename: Omnia G
authors.initials: OG
authors.lastname: Abdel Hamid
authors.forename: Verena
authors.initials: V
authors.lastname: Gossen
authors.forename: Gerhard
authors.initials: G
authors.lastname: Raabe
authors.forename: Salah
authors.initials: S
authors.lastname: Aboulela
mesh_terms: D001562:Benzimidazoles / Q000737:chemistry*; D002942:Circular Dichroism; D015394:Molecular Structure; D009705:Nucleosides / Q000138:chemical synthesis / Q000737:chemistry*
chemical_list: D001562:Benzimidazoles; D009705:Nucleosides; C031000:benzimidazole