title: [The role of COX-2, ALOX12 and iNOS genes in nasal polyposis].
abstract: OBJECTIVE
  The aim of this study was to investigate whether cyclooxygenase-2 (COX-2), arachidonate 12-lipoxygenase (ALOX12) and inducible nitric oxide synthase (iNOS) which are well-known mediators in inflammatory process play a role in nasal polyposis (NP) and to show their roles in initiation and progression of inflammation.
  
  
  METHODS
  We investigated the expression levels of COX-2, ALOX12 and iNOS genes by real-time polymerase chain reaction (PCR) method in NP tissues obtained from 10 patients (4 females, 6 males; mean age ?? years; range 21 to 54 years).
  
  
  RESULTS
  The mRNA levels of COX-2 expression observed in NP was found to be relatively increased, compared to the control tissue (p>0.05). The ALOX12 levels were relatively decreased (p>0.05), while the expression level of iNOS mRNA was significantly higher in NP tissue (p<0.05).
  
  
  CONCLUSIONS
  These data suggest that nitric oxide (NO), a gene product of iNOS, may play a physiological role in the upper airways and also NO is associated with inflammatory processes in the airways.
authors.affiliation: Department of Medical Biology and Genetics, Medical Faculty of Gazi University, Beşevler, Ankara, Turkey. volkanergin@gmail.com
authors.forename: Volkan
authors.initials: V
authors.lastname: Ergin
authors.forename: Akın
authors.initials: A
authors.lastname: Yılmaz
authors.forename: Fatih
authors.initials: F
authors.lastname: Celenk
authors.forename: Sabri
authors.initials: S
authors.lastname: Uslu
authors.forename: Fikret
authors.initials: F
authors.lastname: Ileri
authors.forename: Adnan
authors.initials: A
authors.lastname: Menevşe
mesh_terms: D000328:Adult; D001092:Arachidonate 12-Lipoxygenase / Q000235:genetics* / Q000378:metabolism; D051546:Cyclooxygenase 2 / Q000235:genetics* / Q000378:metabolism; D005260:Female; D006801:Humans; D007249:Inflammation / Q000235:genetics; D008297:Male; D008875:Middle Aged; D009298:Nasal Polyps / Q000235:genetics*; D052247:Nitric Oxide Synthase Type II / Q000235:genetics* / Q000378:metabolism; D060888:Real-Time Polymerase Chain Reaction; D055815:Young Adult
chemical_list: D001092:Arachidonate 12-Lipoxygenase; D052247:Nitric Oxide Synthase Type II; D051546:Cyclooxygenase 2