title: Clinical application of photopic negative response of the flash electroretinogram in primary open-angle Glaucoma.
abstract: OBJECTIVE
  To evaluate the diagnostic performance of the photopic negative response (PhNR) for the detection of primary open-angle glaucoma (POAG).
  
  
  METHODS
  Fifty-two normal subjects (52 eyes) and 173 POAG patients (173 eyes) were studied. The PhNR was elicited using a white stimuli on a white background. The mean deviation (MD) and pattern standard deviation (PSD) of the visual field were measured using standard automated perimetry (SAP). Spectral domain optical coherence tomography (SD-OCT) was used to measure the mean thickness of the retinal nerve fiber layer (RNFL).
  
  
  RESULTS
  In the glaucoma group, as compared to the normal group, the amplitudes of a-waves, b-waves and PhNR were significantly smaller (P<0.001), and the PhNR implicit time was significantly longer (P=0.004). The MD, PSD and mean thickness of the RNFL were significantly correlated with the amplitude of the PhNR (P<0.001). The area under the receiver operating characteristic curve (AUCs) for the amplitudes of a-waves, b-waves and PhNR were 0.853, 0.830 and 0.918, respectively. When the specificity was ≥ 95%, the sensitivities were 60.4%, 54.2% and 85.4% respectively.
  
  
  CONCLUSIONS
  The PhNR amplitude was reduced even when the loss in visual field sensitivity was mild, which suggests that PhNR might be a useful indicator of early glaucoma disease.
authors.affiliation: Shenzhen Eye Hospital, Jinan University, China. lina_h@126.com
authors.forename: Lina
authors.initials: L
authors.lastname: Huang
authors.forename: Xiaoli
authors.initials: X
authors.lastname: Shen
authors.forename: Ning
authors.initials: N
authors.lastname: Fan
authors.forename: Jing
authors.initials: J
authors.lastname: He
mesh_terms: D019540:Area Under Curve; D055253:Color Vision; D004596:Electroretinography / Q000379:methods*; D005901:Glaucoma; D005902:Glaucoma, Open-Angle / Q000175:diagnosis* / Q000503:physiopathology; D006801:Humans; D008875:Middle Aged; D012372:ROC Curve; D012160:Retina / Q000033:anatomy & histology / Q000473:pathology; D012680:Sensitivity and Specificity; D041623:Tomography, Optical Coherence; D058609:Visual Field Tests / Q000379:methods; D014794:Visual Fields / Q000502:physiology*