title: Adsorption of various antimicrobial agents to endotoxin removal polymyxin-B immobilized fiber (Toraymyxin®). Part 2: Adsorption of two drugs to Toraymyxin PMX-20R cartridges.
abstract: In our previous study, the degree of adsorption of 9 representative antimicrobial agents to Toraymyxin(®) PMX-F sheets was quantitatively evaluated. As a result, the adsorption rate was 22.1% for Linezolid in the presence of serum. Therefore, we investigated whether two types of antimicrobial agents (Ciprofroxacin and Linezolid) can be better adsorbed on PMX-F sheets. When the number of PMX-F sheets was increased in a step wise manner, specifically 2, 4, 6, 8 and 12, the adsorption rate increased linearly. In addition, the adsorption to polymyxin-B immobilized fiber (Toraymyxin(®) PMX-20R) cartridges, widely used to remove endotoxins from circulating blood in the treatment of sepsis, was quantitatively evaluated. As a result, in the presence of serum, Linezolid showed adsorption to PMX-20R, and the adsorption rate after 2h was 54.5%, and that after 4h was 65.8%. The results of this study suggest the necessity of monitoring blood antimicrobial concentration during treatment for sepsis with Linezolid, which showed adsorption to PMX-20R in an environment close to a clinical environment.
authors.affiliation: Department of Pharmaceutical Sciences, Meiji Pharmaceutical University, Kiyose, Tokyo 204-8588, Japan.
authors.forename: Ken-ichi
authors.initials: K
authors.lastname: Shimokawa
authors.forename: Ryotaro
authors.initials: R
authors.lastname: Takakuwa
authors.forename: Yuko
authors.initials: Y
authors.lastname: Wada
authors.forename: Noriko
authors.initials: N
authors.lastname: Yamazaki
authors.forename: Fumiyoshi
authors.initials: F
authors.lastname: Ishii
mesh_terms: D000081:Acetamides / Q000097:blood / Q000737:chemistry; D000327:Adsorption; D000900:Anti-Bacterial Agents / Q000737:chemistry*; D000890:Anti-Infective Agents / Q000008:administration & dosage / Q000737:chemistry*; D002851:Chromatography, High Pressure Liquid; D002939:Ciprofloxacin / Q000097:blood / Q000737:chemistry; D004731:Endotoxins / Q000737:chemistry / Q000302:isolation & purification; D006801:Humans; D007700:Kinetics; D000069349:Linezolid; D023303:Oxazolidinones / Q000097:blood / Q000737:chemistry; D011112:Polymyxin B / Q000737:chemistry*; D006435:Renal Dialysis / Q000295:instrumentation; D044967:Serum / Q000737:chemistry
chemical_list: D000081:Acetamides; D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents; D004731:Endotoxins; D023303:Oxazolidinones; D002939:Ciprofloxacin; D000069349:Linezolid; D011112:Polymyxin B