title: The role of biologic mesh in abdominal wall reconstruction: a systematic review of the current literature.
abstract: BACKGROUND
  Biologic mesh in the form of allograft or xenograft products have been used in complicated abdominal hernia repair, but few comparative studies exist.
  
  
  METHODS
  A systematic review of original incisional hernia studies was conducted to include 2 primary end points: hernia recurrence and surgical site occurrence. Analysis of variance and a Satterthwaite t test compared the devices.
  
  
  RESULTS
  Twenty-nine studies were included in this analysis, which included 1,257 patients. The total number of studies and the total subjects for each device include the following: Permacol (Tissue Science Laboratories, Hampshire, UK) (4/64), Surgisis (Cook Medical, Bloomington, IN) (3/87), and Alloderm (LifeCell, Corp, Branchburg, NJ) (23/1,106). Device-specific recurrence rates and surgical site occurrence rates, respectively, were as follows: Alloderm (20.8%, 31.4%), Permacol (10.9%, 25%), and Surgisis (8.0%, 40.2%). A Satterthwaite t test comparison revealed significantly higher numbers of hernia recurrence (P = .006) and surgical site occurrence (P = .04) when comparing Alloderm with Permacol.
  
  
  CONCLUSIONS
  Biologic mesh does play a beneficial role in abdominal wall reconstruction although allograft acellular dermal matrix does have a higher recurrence rate as compared with xenograft products, which limits its current role in hernia repair.
authors.affiliation: Department of Plastic Surgery, The University of Texas Southwestern Medical Center, 1801 Inwood Rd., Dallas, TX 75390, USA.
authors.forename: Evan W
authors.initials: EW
authors.lastname: Beale
authors.forename: Ronald E
authors.initials: RE
authors.lastname: Hoxworth
authors.forename: Edward H
authors.initials: EH
authors.lastname: Livingston
authors.forename: Andrew P
authors.initials: AP
authors.lastname: Trussler
mesh_terms: D061645:Abdominoplasty / Q000379:methods*; D062088:Acellular Dermis; D001672:Biocompatible Materials; D019317:Evidence-Based Medicine; D046449:Hernia, Abdominal / Q000601:surgery*; D059685:Herniorrhaphy / Q000009:adverse effects / Q000379:methods*; D006801:Humans; D055502:Secondary Prevention; D013526:Surgical Mesh; D013529:Surgical Wound Dehiscence / Q000517:prevention & control; D014183:Transplantation, Heterologous
chemical_list: D001672:Biocompatible Materials