title: The coordinated expression, interaction and evolution of the neuroendocrine genes.
abstract: The neuroendocrine system is a complex biological system controlled by various neuropeptides and hormones. The evolution and network properties of neuroendocrine genes are analyzed along with their expression profiles. The neuroendocrine genes show very similar expression profiles and local network properties across a wide range of tissues consistent with the physiological roles of their proteins. Moreover, the coordinated evolution of 10 neuroendocrine genes involved in mammalian reproduction and homeostasis is demonstrated using several methods, such as correlated evolution, relative-rate test, relative-ratio test and codon usage bias. The neuroendocrine genes seem to evolve predominantly under similar selective strengths and regimes of purifying selection, which is well reflected in their evolutionary fingerprints. This result demonstrates for the first time a key role of natural selection in creating and maintaining a well-designed neuroendocrine system at the genomic level. It also indicates that component properties of a complex system at a higher physiological scale may determine component properties at a lower genomic scale and/or vice versa.
authors.affiliation: Centre for Bioinformatics, School of Life Sciences, Pondicherry University, Pondicherry-605 014, India. basant68@email.com
authors.forename: Basant K
authors.initials: BK
authors.lastname: Tiwary
mesh_terms: D003062:Codon / Q000235:genetics; D030541:Databases, Genetic; D019143:Evolution, Molecular; D015870:Gene Expression; D053263:Gene Regulatory Networks; D015894:Genome, Human; D006801:Humans; D008957:Models, Genetic; D009490:Neurosecretory Systems / Q000378:metabolism*; D010802:Phylogeny; D012641:Selection, Genetic; D049490:Systems Biology
chemical_list: D003062:Codon