title: Minimal change disease in graft versus host disease: a podocyte response to the graft?
abstract: Nephrotic syndrome is a rare complication of hematopoietic cell transplantation. It has been suggested that nephrotic syndrome may represent a limited form of graft-versus-host disease although the pathological link between these two entities remains unclear. In this paper, we report a case of a 61-year-old female who underwent nonmyeloablative allogenic stem cell transplantation for T-cell prolymphocytic leukemia and subsequently developed biopsy proven minimal change disease shortly after cessation of her immunosuppression therapy. Urinary CD80 was markedly elevated during active disease and disappeared following corticosteroid-induced remission. We hypothesize that alloreactive donor T cells target the kidney and induce podocyte expression of CD80 that results in proteinuria from limited 'graft versus host' disease.
authors.forename: Janna
authors.initials: J
authors.lastname: Huskey
authors.forename: Chris
authors.initials: C
authors.lastname: Rivard
authors.forename: Han
authors.initials: H
authors.lastname: Myint
authors.forename: Scott
authors.initials: S
authors.lastname: Lucia
authors.forename: Maxwell
authors.initials: M
authors.lastname: Smith
authors.forename: Michiko
authors.initials: M
authors.lastname: Shimada
authors.forename: Takuji
authors.initials: T
authors.lastname: Ishimoto
authors.forename: Carlos
authors.initials: C
authors.lastname: Araya
authors.forename: Eduardo H
authors.initials: EH
authors.lastname: Garin
authors.forename: Richard J
authors.initials: RJ
authors.lastname: Johnson
mesh_terms: D018122:B7-1 Antigen / Q000652:urine; D005260:Female; D006086:Graft vs Host Disease / Q000209:etiology*; D018380:Hematopoietic Stem Cell Transplantation / Q000009:adverse effects*; D006801:Humans; D008875:Middle Aged; D009402:Nephrosis, Lipoid / Q000209:etiology*; D050199:Podocytes / Q000276:immunology*; D011507:Proteinuria / Q000209:etiology; D014184:Transplantation, Homologous
chemical_list: D018122:B7-1 Antigen