title: Synthesis of α-hydroxyphosphonates and their antioxidant properties.
abstract: A series of α-hydroxyphosphonates were synthesized from the reaction of aldehyde (1) with triethylphosphite (2) in the presence of oxone and evaluated for their antioxidant properties against lipid peroxidation, reduced glutathione, superoxide dismutase, and catalase. The majority of the compounds showed promising antioxidant activity. Diethyl anthracen-9-yl (hydroxy) methylphosphonate (3n) is the most potent and biologically active compound against free radicals.
authors.affiliation: Department of Food Technology, Universiti Putra Malaysia, UPM 43400, Serdang, Malaysia. drrmnaidu@gmail.com
authors.forename: Kalla Reddi Mohan
authors.initials: KR
authors.lastname: Naidu
authors.forename: Krishnammagari Suresh
authors.initials: KS
authors.lastname: Kumar
authors.forename: Palanisamy
authors.initials: P
authors.lastname: Arulselvan
authors.forename: Chinnappareddy Bhupendra
authors.initials: CB
authors.lastname: Reddy
authors.forename: Ola
authors.initials: O
authors.lastname: Lasekan
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D015415:Biomarkers / Q000032:analysis; D001921:Brain / Q000187:drug effects / Q000201:enzymology / Q000378:metabolism; D002374:Catalase / Q000378:metabolism; D015195:Drug Design; D005978:Glutathione / Q000378:metabolism; D015227:Lipid Peroxidation / Q000187:drug effects; D015394:Molecular Structure; D063065:Organophosphonates / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D018384:Oxidative Stress / Q000187:drug effects; D051381:Rats; D017208:Rats, Wistar; D013482:Superoxide Dismutase / Q000378:metabolism
chemical_list: D000975:Antioxidants; D015415:Biomarkers; D063065:Organophosphonates; D002374:Catalase; D013482:Superoxide Dismutase; D005978:Glutathione