title: Sesquiterpenoids from the mangrove-derived endophytic fungus Diaporthe sp.
abstract: A new sesquiterpenoid, diaporol A (1), possessing a unique tricyclic lactone framework, eight new drimane sesquiterpenoids, diaporols B-I (2-9), and the known compounds 10 and 11 were isolated from a culture of the mangrove-derived endophyte Diaporthe sp. The absolute configurations of 1-5 were determined by low-temperature (100 K) single-crystal X-ray diffraction with Cu Kα radiation. The compounds were evaluated for cytotoxic activity; however, no compound showed significant cytotoxicity against the tested cell lines at a concentration of 20 μM.
authors.affiliation: Institute of Functional Biomolecules, State Key Laboratory of Pharmaceutical Biotechnology, School of Lifescience, Nanjing University, Nanjing 210093, People's Republic of China.
authors.forename: Le Yun
authors.initials: le Y
authors.lastname: Zang
authors.forename: Wei
authors.initials: W
authors.lastname: Wei
authors.forename: Ye
authors.initials: Y
authors.lastname: Guo
authors.forename: Ting
authors.initials: T
authors.lastname: Wang
authors.forename: Rui Hua
authors.initials: RH
authors.lastname: Jiao
authors.forename: Seik Weng
authors.initials: SW
authors.lastname: Ng
authors.forename: Ren Xiang
authors.initials: RX
authors.lastname: Tan
authors.forename: Hui Ming
authors.initials: HM
authors.lastname: Ge
mesh_terms: D001203:Ascomycota / Q000737:chemistry*; D018360:Crystallography, X-Ray; D003603:Cytotoxins / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D007783:Lactones; D015394:Molecular Structure; D043982:Rhizophoraceae / Q000382:microbiology; D012717:Sesquiterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology
chemical_list: D003603:Cytotoxins; D007783:Lactones; D012717:Sesquiterpenes; C577705:diaporol A