title: Safety of seasonal influenza and influenza A (H1N1) 2009 monovalent vaccines in pregnancy.
abstract: Inactivated influenza vaccines have been given to pregnant women since 1964. Since 2004, the Advisory Committee on Immunization Practices has recommended that pregnant women receive trivalent inactivated influenza vaccine at any time during pregnancy. Studies conducted before 2009 did not identify any safety concerns after trivalent inactivated influenza vaccine in mothers or their infants. During the 2009-2010 influenza A (H1N1) influenza vaccination program, several monitoring systems were established or enhanced to assess whether adverse events were associated with H1N1 2009 monovalent vaccines (2009 H1N1 influenza vaccines). Data from these systems did not identify any safety concerns in pregnant women who received 2009 H1N1 influenza vaccines or their infants. Although live attenuated influenza vaccines are not recommended in pregnant women, a small number of studies have not shown any safety concern among pregnant women or their infants who were inadvertently exposed to these vaccines. This review summarizes US and international safety data for influenza vaccines in pregnant women with an emphasis on 2009 H1N1 influenza vaccines.
authors.affiliation: Immunization Safety Office, Division of Healthcare Quality Promotion, National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, 1600 Clifton Road, MS D26, Atlanta, GA 30333, USA. pmoro@cdc.gov
authors.forename: Pedro L
authors.initials: PL
authors.lastname: Moro
authors.forename: Naomi K
authors.initials: NK
authors.lastname: Tepper
authors.forename: Lisa A
authors.initials: LA
authors.lastname: Grohskopf
authors.forename: Claudia
authors.initials: C
authors.lastname: Vellozzi
authors.forename: Karen
authors.initials: K
authors.lastname: Broder
mesh_terms: D016907:Adverse Drug Reaction Reporting Systems; D004341:Drug Evaluation; D005260:Female; D006801:Humans; D017589:Immunization Programs; D053118:Influenza A Virus, H1N1 Subtype / Q000276:immunology* / Q000472:pathogenicity; D007252:Influenza Vaccines / Q000008:administration & dosage* / Q000009:adverse effects; D007251:Influenza, Human / Q000276:immunology / Q000517:prevention & control* / Q000821:virology; D011159:Population Surveillance; D011247:Pregnancy / Q000276:immunology*; D011251:Pregnancy Complications, Infectious / Q000276:immunology / Q000517:prevention & control; D012621:Seasons; D014611:Vaccination / Q000592:standards*
chemical_list: D007252:Influenza Vaccines