title: Synthesis and properties of DNA containing cyclonucleosides.
abstract: Here, we present efficient syntheses of the R and S diastereomers of 8,5'-cyclo-2'-deoxyadenosine and 6,5'-cyclo-2'-deoxyuridine. We incorporated these interesting nucleosides into DNA to study how the cyclo linkage affects the stability of duplex formation.
authors.affiliation: Department of Chemistry, Boston College, Merkert Chemistry Center, Chestnut Hill, Massachusetts, USA.
authors.forename: Han
authors.initials: H
authors.lastname: Yueh
authors.forename: Hongchuan
authors.initials: H
authors.lastname: Yu
authors.forename: Christopher S
authors.initials: CS
authors.lastname: Theile
authors.forename: Ayan
authors.initials: A
authors.lastname: Pal
authors.forename: Allen
authors.initials: A
authors.lastname: Horhota
authors.forename: Nicholas
authors.initials: N
authors.lastname: Greco
authors.forename: Carl V
authors.initials: CV
authors.lastname: Christianson
authors.forename: Larry W
authors.initials: LW
authors.lastname: McLaughlin
mesh_terms: D004247:DNA / Q000737:chemistry*; D003839:Deoxyadenosines / Q000138:chemical synthesis / Q000737:chemistry*; D009690:Nucleic Acid Conformation; D009691:Nucleic Acid Denaturation; D013816:Thermodynamics
chemical_list: D003839:Deoxyadenosines; C056752:8,5'-cyclo-2'-deoxyadenosine; D004247:DNA