title: A selective fluorescent probe for thiols based on α,β-unsaturated acyl sulfonamide.
abstract: We report herein a novel fluorescent probe based on α,β-unsaturated acyl sulfonamide to detect thiols. The probe has good water solubility and reacts with thiols under aqueous conditions. It reacts selectively with cysteine but not with the other natural amino acids. The probe was subsequently applied to detect intracellular thiols.
authors.affiliation: Department of Biology and Chemistry, City University of Hong Kong, 83 Tat Chee Avenue, Kowloon, Hong Kong, PR China.
authors.forename: Huatang
authors.initials: H
authors.lastname: Zhang
authors.forename: Ping
authors.initials: P
authors.lastname: Wang
authors.forename: Yanxin
authors.initials: Y
authors.lastname: Yang
authors.forename: Hongyan
authors.initials: H
authors.lastname: Sun
mesh_terms: D045744:Cell Line, Tumor; D005456:Fluorescent Dyes / Q000737:chemistry*; D006801:Humans; D006863:Hydrogen-Ion Concentration; D008856:Microscopy, Fluorescence; D009281:Naphthalenes / Q000737:chemistry*; D013438:Sulfhydryl Compounds / Q000032:analysis*; D013449:Sulfonamides / Q000737:chemistry*
chemical_list: D005456:Fluorescent Dyes; D009281:Naphthalenes; D013438:Sulfhydryl Compounds; D013449:Sulfonamides