title: Negative curvature boundaries as wave emitting sites for the control of biological excitable media.
abstract: Understanding the interaction of electric fields with the complex anatomy of biological excitable media is key to optimizing control strategies for spatiotemporal dynamics in those systems. On the basis of a bidomain description, we provide a unified theory for the electric-field-induced depolarization of the substrate near curved boundaries of generalized shapes, resulting in the localized recruitment of control sites. Our findings are confirmed in experiments on cardiomyocyte cell cultures and supported by two-dimensional numerical simulations on a cross section of a rabbit ventricle.
authors.affiliation: Max Planck Institute for Dynamics and Self-Organization, Göttingen, Germany. philip.bittihn@ds.mpg.de
authors.forename: Philip
authors.initials: P
authors.lastname: Bittihn
authors.forename: Marcel
authors.initials: M
authors.lastname: Hörning
authors.forename: Stefan
authors.initials: S
authors.lastname: Luther
mesh_terms: D000818:Animals; D001703:Biophysics / Q000379:methods; D002478:Cells, Cultured; D003198:Computer Simulation; D004574:Electromagnetic Fields; D060733:Electromagnetic Radiation; D006352:Heart Ventricles / Q000166:cytology / Q000528:radiation effects; D008564:Membrane Potentials / Q000502:physiology; D008954:Models, Biological; D032383:Myocytes, Cardiac / Q000502:physiology* / Q000528:radiation effects*; D011817:Rabbits; D051381:Rats; D016277:Ventricular Function, Left / Q000528:radiation effects