title: Mechanism of margination in confined flows of blood and other multicomponent suspensions.
abstract: Flowing blood displays a phenomenon called margination, in which leukocytes and platelets are preferentially found near blood vessel walls, while erythrocytes are depleted from these regions. Here margination is investigated using direct hydrodynamic simulations of a binary suspension of stiff (s) and floppy (f) capsules, as well as a stochastic model that incorporates the key particle transport mechanisms in suspensions-wall-induced hydrodynamic migration and shear-induced pair collisions. The stochastic model allows the relative importance of these two mechanisms to be directly evaluated and thereby indicates that margination, at least in the dilute case, is largely due to the differential dynamics of homogeneous (e.g. s-s) and heterogeneous (s-f) collisions.
authors.affiliation: Department of Chemical and Biological Engineering, University of Wisconsin-Madison, Madison, Wisconsin 53706, USA.
authors.forename: Amit
authors.initials: A
authors.lastname: Kumar
authors.forename: Michael D
authors.initials: MD
authors.lastname: Graham
mesh_terms: D001769:Blood; D006439:Hemodynamics; D057446:Hydrodynamics; D008954:Models, Biological; D009010:Monte Carlo Method; D013535:Suspensions
chemical_list: D013535:Suspensions