title: Stereoselective radical amination of electron-deficient C(sp3)-H bonds by Co(II)-based metalloradical catalysis: direct synthesis of α-amino acid derivatives via α-C-H amination.
abstract: The cobalt(II) complex of 3,5-Di(t)Bu-IbuPhyrin, [Co(P1)], is an effective catalyst for intramolecular amination of electron-deficient C-H bonds, including those adjacent to electron-withdrawing CO(2)R, C(O)NR(2), C(O)R, and CN groups, in excellent yields with high regio- and stereoselectivity. The [Co(P1)]-catalyzed amination system provides a direct method for the synthesis of α-amino acid derivatives from the corresponding carboxylate precursors.
authors.affiliation: Department of Chemistry, University of South Florida, Tampa, Florida 33620-5250, USA.
authors.forename: Hongjian
authors.initials: H
authors.lastname: Lu
authors.forename: Yang
authors.initials: Y
authors.lastname: Hu
authors.forename: Huiling
authors.initials: H
authors.lastname: Jiang
authors.forename: Lukasz
authors.initials: L
authors.lastname: Wojtas
authors.forename: X Peter
authors.initials: XP
authors.lastname: Zhang
mesh_terms: D000586:Amination; D000596:Amino Acids / Q000138:chemical synthesis*; D002244:Carbon / Q000737:chemistry; D002384:Catalysis; D003035:Cobalt / Q000737:chemistry*; D004583:Electrons; D005609:Free Radicals / Q000737:chemistry; D006859:Hydrogen / Q000737:chemistry; D006860:Hydrogen Bonding; D015394:Molecular Structure; D011166:Porphyrins / Q000737:chemistry; D013237:Stereoisomerism
chemical_list: D000596:Amino Acids; D005609:Free Radicals; D011166:Porphyrins; D003035:Cobalt; D002244:Carbon; D006859:Hydrogen