title: Prevalence and predictors of impaired fasting glucose among Nigerian patients with hepatitis B virus infection.
abstract: OBJECTIVE
  Previous studies on the relationship between hepatitis B virus (HBV) infection and type 2 diabetes mellitus (DM) are conflicting. We aimed to elucidate the relationship by investigating the prevalence and predictors of impaired fasting glucose (IFG) in HBV-infected patients.
  
  
  METHODS
  A total of 204 consecutive patients with hepatitis B surface antigen (HBsAg) seropositivity for ≥ 6 months were recruited in a cross-sectional study. Patients with DM were excluded. Information regarding age, gender, ethnicity, residence, family history of DM, alcohol use, and cigarette smoking were obtained using a structured questionnaire. Fasting plasma glucose, lipid profile, liver enzymes and hepatitis Be antigen (HBeAg) were tested.
  
  
  RESULTS
  The participants had a mean age of 33.6 ± 8.4 years and included 123 (60.3%) females, 40 (19.6%) with HBeAg seropositivity, and 29 (14.2%) with family history of DM. The prevalence of IFG was 52 (25.5%). On multivariate analysis, the independent predictors of IFG were family history of DM (OR = 8.23, 95% CI = 2.78-24.31), male gender (OR = 2.83, 95% CI = 1.17-6.64), HBeAg seropositivity (OR = 4.97, 95% CI = 1.87-13.18) and elevated GGT (OR = 7.27, 95% C.I = 2.88-18.35).
  
  
  CONCLUSIONS
  The prevalence of IFG among HBV-infected patients is high. Targeted screening and follow-up of HBV-infected patients for abnormalities of glucose metabolism is recommended.
authors.affiliation: Infectious Diseases Unit, Department of Medicine, University of Nigeria Teaching Hospital, Enugu, Nigeria. mikezindu@yahoo.com
authors.forename: Michael O
authors.initials: MO
authors.lastname: Iroezindu
authors.forename: Godsent C
authors.initials: GC
authors.lastname: Isiguzo
authors.forename: Ekenechukwu E
authors.initials: EE
authors.lastname: Young
mesh_terms: D000328:Adult; D001786:Blood Glucose / Q000378:metabolism; D003920:Diabetes Mellitus / Q000097:blood / Q000453:epidemiology*; D005215:Fasting / Q000097:blood*; D005260:Female; D006509:Hepatitis B / Q000097:blood* / Q000453:epidemiology*; D006514:Hepatitis B Surface Antigens / Q000378:metabolism; D006801:Humans; D008297:Male; D015995:Prevalence; D055815:Young Adult
chemical_list: D001786:Blood Glucose; D006514:Hepatitis B Surface Antigens