title: [Neuroprotective effect of recombinant human erythropoietin-loaded poly(lactic-co-glycolic) acid nanoparticles in rats with intracerebral posttraumatic hematoma].
abstract: The neuroprotective activity of recombinant human erythropoietin (rhEPO) loaded poly(lactic-co-glycolic) acid (PLGA) nanoparticles has been observed in rats with model intracerebral post-traumatic hematoma (hemorrhagic stroke). It is established that rhEPO-loaded PLGA nanoparticles produce a neuroprotective effect in rats with hemorrhagic stroke, which is manifested by reduced number of lethal outcomes and animals with neurological disorders. Treatment with rhEPO-loaded PLGA prevented amnesia of passive avoidance reflex (PAR), which was produced by the hemorrhagic stroke, and reduced the area of brain damage caused by the intracerebral hematoma. These effects were recorded during one-week observation period. Native rhEPO exhibited a similar, but much less pronounced effect on the major disorders caused by the model hemorrhagic stroke in rats.
authors.forename: O S
authors.initials: OS
authors.lastname: Elizarova
authors.forename: S A
authors.initials: SA
authors.lastname: Litvinova
authors.forename: V Iu
authors.initials: VIu
authors.lastname: Balaban'ian
authors.forename: I V
authors.initials: IV
authors.lastname: Barskov
authors.forename: S V
authors.initials: SV
authors.lastname: Novikova
authors.forename: E V
authors.initials: EV
authors.lastname: Stel'mashuk
authors.forename: T L
authors.initials: TL
authors.lastname: Garibova
authors.forename: T A
authors.initials: TA
authors.lastname: Voronina
mesh_terms: D000647:Amnesia / Q000517:prevention & control*; D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects; D020202:Cerebral Hemorrhage, Traumatic / Q000188:drug therapy* / Q000401:mortality / Q000503:physiopathology; D004195:Disease Models, Animal; D004337:Drug Carriers / Q000737:chemistry; D004921:Erythropoietin / Q000008:administration & dosage / Q000627:therapeutic use*; D006801:Humans; D019344:Lactic Acid / Q000737:chemistry; D008297:Male; D053758:Nanoparticles / Q000737:chemistry; D018696:Neuroprotective Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D010316:Particle Size; D011100:Polyglycolic Acid / Q000737:chemistry; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D051381:Rats; D011994:Recombinant Proteins / Q000008:administration & dosage / Q000627:therapeutic use; D015996:Survival Rate
chemical_list: D004337:Drug Carriers; D018696:Neuroprotective Agents; D011994:Recombinant Proteins; D004921:Erythropoietin; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D011100:Polyglycolic Acid; D019344:Lactic Acid