title: Systemic mastocytosis: disease overview, pathogenesis, and treatment.
abstract: The clinical presentation of mastocytosis is diverse, and patients may not fit the classical description. Diagnosis requires a bone marrow examination, including immunohistochemical stains for mast cell tryptase or CD117. The treatment of adult systemic mastocytosis is highly individualized. This article presents an overview of systemic mastocytosis and describes its pathogenesis and treatment.
authors.affiliation: Division of Hematology, Department of Medicine, Mayo Clinic, 200 First Street Southwest, Rochester, MN 55905, USA. Pardanani.animesh@mayo.edu
authors.forename: Animesh
authors.initials: A
authors.lastname: Pardanani
mesh_terms: D006801:Humans; D034721:Mastocytosis, Systemic / Q000473:pathology* / Q000628:therapy*