title: [The efficacy of polychromatic visible and infrared radiation used for the postoperative immunological rehabilitation of patients with breast cancer].
abstract: The immunological rehabilitation of the patients with oncological problems after the completion of standard anti-tumour therapy remains a topical problem in modern medicine. The up-to-date phototherapeutic methods find the increasingly wider application for the treatment of such patients including the use of monochromatic visible (VIS) and near infrared (nIR) radiation emitted from lasers and photodiodes. The objective of the present study was to substantiate the expediency of postoperative immune rehabilitation of the patients with breast cancer (BC) by means of irradiation of the body surface with polychromatic visible (pVIS) in combination with polychromatic infrared (pIR) light similar to the natural solar radiation without its minor UV component. The study included 19 patients with stage I--II BC at the mean age of 54.0 +/- 4.28 years having the infiltrative-ductal form of the tumour who had undergone mastectomy. These patients were randomly allocated to two groups, one given the standard course of postoperative rehabilitation (control), the other (study group) additionally treated with pVIS + pIR radiation applied to the lumbar-sacral region from days 1 to 7 after surgery. A Bioptron-2 phototherapeutic device, Switzerland, was used for the purpose (480-3400 nm, 40 mW/cm2, 12 J/cm2, with the light spot diameter of 15 cm). The modern standard immunological methods were employed. It was found that mastectomy induced changes of many characteristics of cellular and humoral immunity; many of them in different patients were oppositely directed. These changes were apparent within the first 7 days postoperatively. The course of phototherapy (PT) was shown to prevent the postoperative decrease in the counts of monocytes and natural killer (NK) cells, the total amount of CD3+ -T-lymphocytes (LPC), CD4+ -T-helpers, activated T-lymphocytes (CD3+ HLA-DR+ cells) and IgA levels as well as intracellular digestion rate of neutrophil-phagocyted bacteria. Moreover PT promoted faster normalization of postoperative leukocytosis and activation of cytotoxic CD8+ -T-LPC, reduced the elevated concentration of immune complexes in blood. Among the six tested cytokines, viz. IL-1beta, TNF-alpha, IL-6, IL-10, IFN-alpha, and IFN-gamma, only the latter two underwent significant elevation of their blood concentrations (IL-6 within 1 day) and IFN-gamma (within 7 days after mastectomy). The course of PT resulted in the decrease of their levels to the initial values. The follow-up of the treated patients during 4 years revealed neither recurrence of the disease nor the appearance of metastases.
authors.forename: N A
authors.initials: NA
authors.lastname: zhevago
authors.forename: K A
authors.initials: KA
authors.lastname: Samoĭlova
authors.forename: N I
authors.initials: NI
authors.lastname: Davydova
authors.forename: N V
authors.initials: NV
authors.lastname: Bychkova
authors.forename: T V
authors.initials: TV
authors.lastname: Glazanova
authors.forename: Zh V
authors.initials: ZhV
authors.lastname: Chubukina
authors.forename: A I
authors.initials: AI
authors.lastname: Buĭniakova
authors.forename: A A
authors.initials: AA
authors.lastname: Zimin
mesh_terms: D001943:Breast Neoplasms / Q000097:blood / Q000276:immunology / Q000534:rehabilitation / Q000601:surgery; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology / Q000378:metabolism; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology / Q000378:metabolism; D016207:Cytokines / Q000097:blood / Q000276:immunology; D005260:Female; D006801:Humans; D056724:Immunity, Humoral; D007167:Immunotherapy / Q000295:instrumentation / Q000379:methods; D007259:Infrared Rays / Q000627:therapeutic use*; D008213:Lymphocyte Activation; D018655:Lymphocyte Count; D008875:Middle Aged; D010789:Phototherapy / Q000295:instrumentation / Q000379:methods
chemical_list: D016207:Cytokines