title: Effects of okadaic acid on haemocytes from Mytilus galloprovincialis: a comparison between field and laboratory studies.
abstract: Individuals of Mytilus galloprovincialis, contaminated with Diarrheic Shellfish Poisoning (DSP) toxins, were studied with the aim to correlate the okadaic acid (OA) body burden and the percentage of damaged haemocytes by quantifying annexin V positive cells by flow cytometry. Results showed less percentage of damaged haemocytes in high OA contaminated samples. These data were compared with results of in vitro assays of mussel haemocytes exposed to increased concentrations of OA. Similarly, haemocytes exposed to the most concentrated OA solution were less damaged.
authors.affiliation: Department of Cell and Molecular Biology, Campus A Zapateira s/n, University of A Coruña, A Coruña, Spain.
authors.forename: Maria
authors.initials: M
authors.lastname: Prado-Alvarez
authors.forename: Fernanda
authors.initials: F
authors.lastname: Flórez-Barrós
authors.forename: Alexia
authors.initials: A
authors.lastname: Sexto-Iglesias
authors.forename: Josefina
authors.initials: J
authors.lastname: Méndez
authors.forename: Juan
authors.initials: J
authors.lastname: Fernandez-Tajes
mesh_terms: D000818:Animals; D017304:Annexin A5 / Q000032:analysis / Q000494:pharmacology; D004791:Enzyme Inhibitors / Q000494:pharmacology; D006434:Hemocytes / Q000187:drug effects; D008387:Marine Toxins / Q000032:analysis / Q000378:metabolism; D049878:Mytilus / Q000187:drug effects*; D019319:Okadaic Acid / Q000494:pharmacology*; D012107:Research Design / Q000592:standards
chemical_list: D017304:Annexin A5; D004791:Enzyme Inhibitors; D008387:Marine Toxins; D019319:Okadaic Acid