title: An experimental study of tissue reaction to hyaluronic acid (Restylane) and polymethylmethacrylate (Metacrill) in the mouse.
abstract: The aging skin is a challenge for medical science. Plastic surgeons and dermatologists are called every day to solve problems like filling wrinkles or folds. The material used must be biocompatible because abnormal reactions may cause catastrophic results. This study analyzes the biological behavior of polymethylmethacrylate (Metacrill) and hyaluronic acid (Restylane), using a histopathologic study in mice. A prospective study was performed using 40 mice for each substance: polymethylmethacrylate or hyaluronic acid was injected into the right ear, the left ear been used as a control. Histopathologic analyses of the right ear, liver, and kidney were performed at intervals during the study and revealed the development of a granulomatous reaction with fibrosis and absorption of spheres and signs of liver and kidney sistematization for polymethylmethacrylate. A discrete cellular reaction, with less formation of fibrosis, and no giant cells were seen in the mice injected with hyaluronic acid.
authors.affiliation: Department of pathology, Brazilian Society of Plastic Surgery, Brasilia. scrmacedo@yahoo.com.br
authors.forename: Simone C
authors.initials: SC
authors.lastname: Rosa
authors.forename: Jefferson L S
authors.initials: JL
authors.lastname: Macedo
authors.forename: Albino V
authors.initials: AV
authors.lastname: Magalhães
mesh_terms: D000818:Animals; D001672:Biocompatible Materials; D001706:Biopsy; D056486:Chemical and Drug Induced Liver Injury / Q000209:etiology / Q000473:pathology; D003357:Cosmetic Techniques / Q000009:adverse effects; D005355:Fibrosis; D015726:Giant Cells / Q000187:drug effects / Q000473:pathology; D015745:Granuloma, Foreign-Body / Q000139:chemically induced / Q000473:pathology; D006820:Hyaluronic Acid / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000494:pharmacology / Q000633:toxicity; D007267:Injections; D007668:Kidney / Q000187:drug effects* / Q000473:pathology; D007674:Kidney Diseases / Q000139:chemically induced / Q000473:pathology; D008099:Liver / Q000187:drug effects* / Q000473:pathology; D008297:Male; D051379:Mice; D019904:Polymethyl Methacrylate / Q000008:administration & dosage / Q000494:pharmacology* / Q000633:toxicity; D012867:Skin / Q000187:drug effects* / Q000473:pathology; D013997:Time Factors
chemical_list: D001672:Biocompatible Materials; D006820:Hyaluronic Acid; D019904:Polymethyl Methacrylate; C445361:Restylane