title: Resveratrol upregulated heat shock proteins and extended the survival of G93A-SOD1 mice.
abstract: In the present study, we investigated whether resveratrol, a SIRT1 activator, can suppress the motor neuron degeneration in a transgenic mouse model of amyotrophic lateral sclerosis. Chronic intraperitoneal injection of resveratrol delayed the disease onset and extended survival of the transgenic mice overexpressing G93A-SOD1. The number of surviving motor neurons increased in the resveratrol-injected G93A mice. Importantly, the levels of Hsp25 and Hsp70 were elevated while the level of heat shock factor 1 (HSF1) acetylation decreased in the spinal cords of the resveratrol-injected G93A mice. Our data suggest that resveratrol may protect motor neurons from the mutant SOD1-induced neurotoxicity by promoting SIRT1-mediated deacetylation of HSF1 and subsequent upregulation of Hsps.
authors.affiliation: Department of Molecular Biology, Sejong University, 98 Gunja-dong, Gwangjin-gu, Seoul 143-747, Korea.
authors.forename: Soyoung
authors.initials: S
authors.lastname: Han
authors.forename: Jong-Ryoul
authors.initials: JR
authors.lastname: Choi
authors.forename: Ki
authors.initials: K
authors.lastname: Soon Shin
authors.forename: Shin Jung
authors.initials: SJ
authors.lastname: Kang
mesh_terms: D000690:Amyotrophic Lateral Sclerosis / Q000188:drug therapy* / Q000235:genetics / Q000401:mortality*; D000818:Animals; D000975:Antioxidants / Q000627:therapeutic use*; D004268:DNA-Binding Proteins / Q000378:metabolism; D004195:Disease Models, Animal; D005904:Glial Fibrillary Acidic Protein / Q000378:metabolism; D018840:HSP70 Heat-Shock Proteins / Q000235:genetics / Q000378:metabolism; D000076249:Heat Shock Transcription Factors; D006360:Heat-Shock Proteins / Q000378:metabolism*; D006801:Humans; D016177:Macrophage-1 Antigen / Q000378:metabolism; D051379:Mice; D008810:Mice, Inbred C57BL; D008822:Mice, Transgenic; D018832:Molecular Chaperones; D009046:Motor Neurons / Q000187:drug effects; D009363:Neoplasm Proteins / Q000378:metabolism; D000077185:Resveratrol; D013116:Spinal Cord / Q000473:pathology; D013267:Stilbenes / Q000627:therapeutic use*; D013482:Superoxide Dismutase / Q000235:genetics; D016019:Survival Analysis; D014157:Transcription Factors / Q000378:metabolism; D015854:Up-Regulation / Q000187:drug effects* / Q000235:genetics
chemical_list: D000975:Antioxidants; D004268:DNA-Binding Proteins; D005904:Glial Fibrillary Acidic Protein; D018840:HSP70 Heat-Shock Proteins; D000076249:Heat Shock Transcription Factors; D006360:Heat-Shock Proteins; C486113:Hsbp1 protein, mouse; C490017:Hsf1 protein, mouse; D016177:Macrophage-1 Antigen; D018832:Molecular Chaperones; D009363:Neoplasm Proteins; D013267:Stilbenes; D014157:Transcription Factors; C109415:SOD1 G93A protein; D013482:Superoxide Dismutase; D000077185:Resveratrol