title: Polymorphisms of catechol estrogens metabolism pathway genes and breast cancer risk in Mexican women.
abstract: Breast cancer is associated to estrogen exposure. Allelic variants involved in estrogen metabolism might change the risk of developing this neoplasia. We examined the potential association of breast cancer risk in Mexican women with the polymorphisms CYP1A1 rs1048943, CYP1B1 rs1056836, COMT rs4680, GSTP1 rs1695, GSTT1 null and GSTM1 null which are involved in estrogen metabolism pathway. This study included 150 cases and 150 controls. A significant association was observed between, CYP1A1 rs1048943 (OR = 1.95, C.I. 1.13-3.36) and GSTP1 rs1695 (OR = 2.39, C.I. 1.24-4.24) polymorphisms with the risk of breast cancer. This risk was increased when the women were stratified according to their menopausal status. The results show that breast cancer risk significantly increases in women with 3-6 risk polymorphisms (OR = 3.75, C.I. 1.44-9.74).
authors.affiliation: Departamento de Medicina Genómica y Toxicología Ambiental, Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México, México D.F., Mexico.
authors.forename: O C
authors.initials: OC
authors.lastname: Martínez-Ramírez
authors.forename: R
authors.initials: R
authors.lastname: Pérez-Morales
authors.forename: C
authors.initials: C
authors.lastname: Castro
authors.forename: A
authors.initials: A
authors.lastname: Flores-Díaz
authors.forename: K E
authors.initials: KE
authors.lastname: Soto-Cruz
authors.forename: A
authors.initials: A
authors.lastname: Astorga-Ramos
authors.forename: M E
authors.initials: ME
authors.lastname: Gonsebatt
authors.forename: L
authors.initials: L
authors.lastname: Casas
authors.forename: M
authors.initials: M
authors.lastname: Valdés-Flores
authors.forename: J
authors.initials: J
authors.lastname: Rubio
mesh_terms: D000328:Adult; D000368:Aged; D001189:Aryl Hydrocarbon Hydroxylases / Q000235:genetics; D001943:Breast Neoplasms / Q000235:genetics* / Q000378:metabolism; D016022:Case-Control Studies; D002394:Catechol O-Methyltransferase / Q000235:genetics; D019363:Cytochrome P-450 CYP1A1 / Q000235:genetics; D065633:Cytochrome P-450 CYP1B1; D002393:Estrogens, Catechol / Q000378:metabolism*; D005260:Female; D005838:Genotype; D051549:Glutathione S-Transferase pi / Q000235:genetics; D005982:Glutathione Transferase / Q000235:genetics; D006801:Humans; D008593:Menopause / Q000378:metabolism; D008800:Mexico; D008875:Middle Aged; D011110:Polymorphism, Genetic; D012189:Retrospective Studies; D012307:Risk Factors; D015398:Signal Transduction / Q000235:genetics
chemical_list: D001189:Aryl Hydrocarbon Hydroxylases; D002394:Catechol O-Methyltransferase; D019363:Cytochrome P-450 CYP1A1; D065633:Cytochrome P-450 CYP1B1; D002393:Estrogens, Catechol; D051549:Glutathione S-Transferase pi; D005982:Glutathione Transferase; C569463:CYP1A1 protein, human; C585496:CYP1B1 protein, human; C413545:glutathione S-transferase T1; C496556:GSTP1 protein, human