title: Sulphadiazine-induced renal stones in a 63-year-old HIV-infected man treated for toxoplasmosis.
abstract: A 63-year-old man was admitted for investigation of blurred vision and multiple ring-enhancing lesions on cranial MRI. Histopathological examination of tissue obtained at brain biopsy showed multiple Toxoplasma gondii cysts. He was started on a combination of sulphadiazine and pyrimethamine for cerebral toxoplasmosis and was subsequently diagnosed with HIV-1 infection. He then developed acute renal failure and flank pain and was diagnosed with bilateral vesico-uretric calculi requiring bilateral stent insertion. The retrieved renal calculi were negative for the common stones that are routinely tested for in our laboratory and had the macroscopic characteristics of a sulphadiazine stone. His renal failure responded to cessation of the sulphadiazine.
authors.affiliation: Department of Immunology, Royal Perth Hospital, Perth, Western Australia, Australia. Ben.McGettigan@health.wa.gov.au
authors.forename: Benjamin David
authors.initials: BD
authors.lastname: McGettigan
authors.forename: Meilyn
authors.initials: M
authors.lastname: Hew
authors.forename: Elizabeth
authors.initials: E
authors.lastname: Phillips
authors.forename: Andrew
authors.initials: A
authors.lastname: McLean-Tooke
mesh_terms: D017088:AIDS-Related Opportunistic Infections / Q000175:diagnosis / Q000188:drug therapy*; D000981:Antiprotozoal Agents / Q000009:adverse effects* / Q000627:therapeutic use; D003937:Diagnosis, Differential; D015497:HIV-1; D006801:Humans; D007669:Kidney Calculi / Q000139:chemically induced*; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D059906:Neuroimaging; D013411:Sulfadiazine / Q000009:adverse effects* / Q000627:therapeutic use; D016781:Toxoplasmosis, Cerebral / Q000175:diagnosis / Q000188:drug therapy*
chemical_list: D000981:Antiprotozoal Agents; D013411:Sulfadiazine