title: The roles of FADD in extrinsic apoptosis and necroptosis.
abstract: Fas-associated protein with death domain (FADD), an adaptor that bridges death receptor signaling to the caspase cascade, is indispensible for the induction of extrinsic apoptotic cell death. Interest in the non-apoptotic function of FADD has greatly increased due to evidence that FADD-deficient mice or dominant-negative FADD transgenic mice result in embryonic lethality and an immune defect without showing apoptotic features. Numerous studies have suggested that FADD regulates cell cycle progression, proliferation, and autophagy, affecting these phenomena. Recently, programmed necrosis, also called necroptosis, was shown to be a key mechanism that induces embryonic lethality and an immune defect. Supporting these findings, FADD was shown to be involved in various necroptosis models. In this review, we summarize the mechanism of extrinsic apoptosis and necroptosis, and discuss the in vivo and in vitro roles of FADD in necroptosis induced by various stimuli.
authors.affiliation: Department of Biochemistry, College of Life Science and Biotechnology, Yonsei University, Seoul 120-749, Korea. ewlee@yonsei.ac.kr
authors.forename: Eun-Woo
authors.initials: EW
authors.lastname: Lee
authors.forename: Jinho
authors.initials: J
authors.lastname: Seo
authors.forename: Manhyung
authors.initials: M
authors.lastname: Jeong
authors.forename: Sangsik
authors.initials: S
authors.lastname: Lee
authors.forename: Jaewhan
authors.initials: J
authors.lastname: Song
mesh_terms: D000818:Animals; D017209:Apoptosis / Q000276:immunology*; D053181:Caspase 8 / Q000378:metabolism; D053200:Fas-Associated Death Domain Protein / Q000378:metabolism*; D009336:Necrosis; D053218:Receptors, Death Domain / Q000378:metabolism; D015398:Signal Transduction / Q000276:immunology; D051193:Toll-Like Receptors / Q000378:metabolism; D048069:Tumor Necrosis Factors / Q000378:metabolism
chemical_list: D053200:Fas-Associated Death Domain Protein; D053218:Receptors, Death Domain; D051193:Toll-Like Receptors; D048069:Tumor Necrosis Factors; D053181:Caspase 8