title: Serum high-density lipoprotein cholesterol and progression to arterial stiffness in middle-aged and elderly Chinese.
abstract: OBJECTIVE
  Low high-density lipoprotein cholesterol (HDL-c) is a risk factor for cardiovascular disease. Brachial-ankle pulse wave velocity (baPWV) is an indicator of arterial stiffness, which is recognized as a predictor of cardiovascular disease. The aim of this study was to investigate the association between HDL-c and baPWV among middle-aged and elderly Chinese.
  
  
  METHODS
  A total number of 1133 Chinese (430 men, 703 women) aged from 50 to 90 years old were recruited from Shanghai downtown district. The baPWV and major cardiovascular risk factors of the participants were measured.
  
  
  RESULTS
  Serum HDL-c was negatively correlated with baPWV (r = -0.143, P < 0.001) after adjustment for age and gender. Multivariate linear regression analysis demonstrated that age (P < 0.001), systolic blood pressure (P < 0.001), HDL-c (P < 0.001), smoking (P = 0.001), BMI (P = 0.002), fasting plasma glucose (P = 0.004), and white blood cell (P = 0.005) were independently associated with baPWV. After multiple adjustments, participants in the highest quartile of HDL-c had an odds ratio of 0.442 (95% CI 0.268-0.729) for developing high arterial stiffness compared with participants in the lowest quartile. The association remained significant after further adjustment for major cardiovascular risk factors.
  
  
  CONCLUSIONS
  HDL-c has an independent protective effect on arterial stiffness in middle-aged and elderly Chinese. Early detection of HDL-c level is important in high risk populations with arterial stiffness. Increasing HDL-c level may be an attractive therapeutic target for the prevention of arterial function and subsequent disease.
authors.affiliation: Department of Endocrinology and Diabetology, Huashan Hospital, Shanghai Medical College, Fudan University, No.12, Wulumuqi Middle Road, Shanghai 200040, China.
authors.forename: W W
authors.initials: WW
authors.lastname: Zhao
authors.forename: Y H
authors.initials: YH
authors.lastname: Yang
authors.forename: B
authors.initials: B
authors.lastname: Lu
authors.forename: X C
authors.initials: XC
authors.lastname: Feng
authors.forename: M
authors.initials: M
authors.lastname: He
authors.forename: Z H
authors.initials: ZH
authors.lastname: Yang
authors.forename: J
authors.initials: J
authors.lastname: Wen
authors.forename: Z Y
authors.initials: ZY
authors.lastname: Zhang
authors.forename: Z
authors.initials: Z
authors.lastname: Yang
authors.forename: Q
authors.initials: Q
authors.lastname: Li
authors.forename: Z
authors.initials: Z
authors.lastname: Ye
authors.forename: W
authors.initials: W
authors.lastname: Gong
authors.forename: R M
authors.initials: RM
authors.lastname: Hu
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000375:Aging; D055109:Ankle Brachial Index; D044466:Asian People; D015415:Biomarkers / Q000097:blood; D001808:Blood Vessels / Q000503:physiopathology*; D002318:Cardiovascular Diseases / Q000097:blood / Q000453:epidemiology / Q000503:physiopathology*; D002681:China / Q000453:epidemiology; D008076:Cholesterol, HDL / Q000097:blood*; D015331:Cohort Studies; D018450:Disease Progression; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D063177:Pulse Wave Analysis; D012307:Risk Factors; D014504:Urban Health; D059289:Vascular Stiffness
chemical_list: D015415:Biomarkers; D008076:Cholesterol, HDL