title: [Pathophysiological role of tissue renin-angiotensin-aldosterone system (RAAS) in human atherosclerosis].
abstract: Renin-angiotensin-aldosterone system (RAAS) has been demonstrated to play an important role in the pathogenesis of atherosclerosis development both in animal experiments and in clinical studies. Numerous clinical studies have shown that blockade of RAAS exerts beneficial effects to restore the impaired endothelial function and to reduce the mortality and morbidity of cardiovascular diseases beyond their blood pressure lowering effect. However, the underlying mechanisms of stabilizing vulnerable plaque and inhibiting plaque rupture associated with acute coronary syndrome have not yet been fully elucidated. Here, we summarized the characteristics of tissue RAAS expressions in human atherosclerotic lesions and assessed their therapeutic relevance in the prevention of atherosclerotic cardiovascular diseases.
authors.affiliation: Department of Cardiovascular Medicine, Kyoto Prefectural University of Medicine.
authors.forename: Kensuke
authors.initials: K
authors.lastname: Fukui
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Yamada
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Matsubara
mesh_terms: D000804:Angiotensin II / Q000494:pharmacology; D000806:Angiotensin-Converting Enzyme Inhibitors / Q000627:therapeutic use*; D000818:Animals; D050197:Atherosclerosis / Q000150:complications / Q000188:drug therapy / Q000473:pathology* / Q000517:prevention & control; D002318:Cardiovascular Diseases / Q000188:drug therapy / Q000209:etiology / Q000473:pathology; D006801:Humans; D012084:Renin-Angiotensin System / Q000502:physiology*; D016896:Treatment Outcome
chemical_list: D000806:Angiotensin-Converting Enzyme Inhibitors; D000804:Angiotensin II