title: Triterpenoid glycosides from the stems of Gordonia kwangsiensis.
abstract: Eleven oleanane-type triterpenoid glycosides, named gordonsaponins A-K, were isolated from the stems of Gordonia kwangsiensis. Their structures were elucidated by spectroscopic and chemical methods. The cytotoxic activities of all eleven were evaluated against five human tumor cell lines (HCT-8, Bel-7402, BGC-823, A549, and A2780), with only one having activity against all tested cell lines, with IC₅₀ values ranging from 0.1 to 2.41 μM.
authors.affiliation: State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, PR China.
authors.forename: Hui-Zheng
authors.initials: HZ
authors.lastname: Fu
authors.forename: Chuang-Jun
authors.initials: CJ
authors.lastname: Li
authors.forename: Jing-Zhi
authors.initials: JZ
authors.lastname: Yang
authors.forename: Xiao-Guang
authors.initials: XG
authors.lastname: Chen
authors.forename: Dong-Ming
authors.initials: DM
authors.lastname: Zhang
mesh_terms: D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D004354:Drug Screening Assays, Antitumor; D006027:Glycosides / Q000737:chemistry* / Q000494:pharmacology*; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D028242:Theaceae / Q000737:chemistry*; D014315:Triterpenes / Q000737:chemistry* / Q000494:pharmacology*
chemical_list: D006027:Glycosides; D014315:Triterpenes