title: The immunologic injury composite with balloon injury leads to dyslipidemia: a robust rabbit model of human atherosclerosis and vulnerable plaque.
abstract: Atherosclerosis is a condition in which a lipid deposition, thrombus formation, immune cell infiltration, and a chronic inflammatory response, but its systemic study has been hampered by the lack of suitable animal models, especially in herbalism fields. We have tried to perform a perfect animal model that completely replicates the stages of human atherosclerosis. This is the first combined study about the immunologic injury and balloon injury based on the cholesterol diet. In this study, we developed a modified protocol of the white rabbit model that could represent a novel approach to studying human atherosclerosis and vulnerable plaque.
authors.affiliation: Office building, Rm 309, First Teaching Hospital of Tianjin University of TCM, No. 314, An Shan Xi Road, Nan Kai District, Tianjin 300193, China.
authors.forename: Guangyin
authors.initials: G
authors.lastname: Zhang
authors.forename: Ming
authors.initials: M
authors.lastname: Li
authors.forename: Liangjun
authors.initials: L
authors.lastname: Li
authors.forename: Yingzhi
authors.initials: Y
authors.lastname: Xu
authors.forename: Peng
authors.initials: P
authors.lastname: Li
authors.forename: Cui
authors.initials: C
authors.lastname: Yang
authors.forename: Yanan
authors.initials: Y
authors.lastname: Zhou
authors.forename: Junping
authors.initials: J
authors.lastname: Zhang
mesh_terms: D000818:Animals; D050197:Atherosclerosis / Q000209:etiology / Q000276:immunology*; D021721:Balloon Occlusion / Q000009:adverse effects*; D002791:Cholesterol, Dietary / Q000009:adverse effects*; D016207:Cytokines / Q000276:immunology*; D004195:Disease Models, Animal; D050171:Dyslipidemias / Q000209:etiology / Q000276:immunology*; D006801:Humans; D008297:Male; D011817:Rabbits
chemical_list: D002791:Cholesterol, Dietary; D016207:Cytokines