title: Collagenase for Dupuytren's disease of the thumb.
abstract: Injectable collagenase is an alternative to surgical   treatment for Dupuytren's disease. Previous studies have reported   on the effectiveness of collagenase in finger contractures. This   prospective study reports on the short-term safety and efficacy   of collagenase treatment in five thumb and first web space Dupuytren's   contractures. The thumb and first web space contractures were treated   with injectable collagenase in four consecutive patients (five hands) with   experience of previous surgical digital fasciectomy. The thumb contracture   was measured by angle and span in two planes of thumb extension   and abduction before injection and after manipulation. Collagenase   treatment resulted in release of the contracture with a mean increase   in thumb to index angle from 23° (10° to 35°) to 56° (45° to 60°)   in extension and from 30° (10° to 50°) to 58° (50° to 65°) in abduction   and a mean increase in span from 1.9 cm (1 to 3.5) to 3.9 cm (3   to 5) in extension and from 2.4 cm (1.5 to 3.5) to 3.9 cm (3 to   4.5) in abduction. All patients reported an increased range of movement   and function and described collagenase therapy as preferable to   surgery. In the short-term collagenase is an effective, well-tolerated   and safe alternative to surgery for Dupuytren's disease of the thumb.
authors.affiliation: Oxford University Hospitals NHS Trust, Department of Plastic, Reconstructive and Hand Surgery, John Radcliffe Hospital, Oxford OX3 9DU, UK.
authors.forename: C L
authors.initials: CL
authors.lastname: Bendon
authors.forename: H P
authors.initials: HP
authors.lastname: Giele
mesh_terms: D000368:Aged; D017364:Collagenases / Q000008:administration & dosage*; D004387:Dupuytren Contracture / Q000188:drug therapy*; D005260:Female; D006801:Humans; D015552:Injections, Intralesional; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D013933:Thumb
chemical_list: D017364:Collagenases; C570746:xiapex