title: [Use of sugammadex in patients undergoing caesarean section using general anesthesia with rocuronium].
abstract: Recently, rocuronium is being used in patients for caesarean section undergoing general anesthesia instead of suxamethonium. An increased dose of rocuronium improves intubating conditions but prolongs neuromuscular blockade. Sugammadex reverses rapidly and predictably even profound rocuronium-induced neuromuscular blockade. We experienced 13 cases of caesarean section patients undergoing general anesthesia with thiopental (3.5 mg x kg(-1)) and rocuronium (0.9 mg x kg(-1)). At the end of surgery, sugammadex (2 mg x kg(-1)) was administered every 3 minutes repeatedly until TOF>0.9. In two patients, neuromuscular blockade spontaneously recovered to TOF>0.9 at the end of surgery. In most patients administered sugammadex, TOF recovered to more than 0.9 within a few minutes. However, in one patient who had chronic renal failure (creatinine clearance rate: 12 ml x min(-1)), 10 minutes were required for TOF to recover to more than 0.7, and TOF never reached 0.9. All patients were successfully intubated at the first attempt. No signs of recurarization or adverse effects related to sugammadex were noted in the perioperative period.
authors.affiliation: Department of Anesthesiology, Tohoku University Hospital, Sendai 980-8574.
authors.forename: Masakazu
authors.initials: M
authors.lastname: Shibusawa
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Ejima
authors.forename: Ryou
authors.initials: R
authors.lastname: Nishino
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Toyama
authors.forename: Shin
authors.initials: S
authors.lastname: Kurosawa
mesh_terms: D000328:Adult; D000732:Androstanols / Q000037:antagonists & inhibitors; D000762:Anesthesia Recovery Period; D000768:Anesthesia, General; D000773:Anesthesia, Obstetrical; D002585:Cesarean Section; D005260:Female; D006801:Humans; D003473:Neuromuscular Nondepolarizing Agents / Q000037:antagonists & inhibitors; D011247:Pregnancy; D000077123:Rocuronium; D000077122:Sugammadex; D013874:Thiopental; D055815:Young Adult; D047408:gamma-Cyclodextrins / Q000008:administration & dosage* / Q000494:pharmacology
chemical_list: D000732:Androstanols; D003473:Neuromuscular Nondepolarizing Agents; D047408:gamma-Cyclodextrins; D000077122:Sugammadex; D013874:Thiopental; D000077123:Rocuronium