title: Targeted cargo delivery in senescent cells using capped mesoporous silica nanoparticles.
abstract: Learning to let go with age: Intracellular controlled release of molecules within senescent cells was achieved using mesoporous silica nanoparticles (MSNs) capped with a galacto-oligosaccharide (GOS) to contain the cargo molecules (magenta spheres; see scheme). The GOS is a substrate of the senescent biomarker, senescence-associated β-galactosidase (SA-β-gal), and releases the cargo upon entry into SA-β-gal expressing cells.
authors.affiliation: Centro de Reconocimiento Molecular y Desarrollo Tecnológico (IDM), Unidad Mixta Universitat Politècnica de València-Universitat de València. CIBER de Bioingeniería, Biomateriales y Nanomedicina (CIBER-BBN), Camino de Vera s/n, 46022 Valencia (Spain).
authors.forename: Alessandro
authors.initials: A
authors.lastname: Agostini
authors.forename: Laura
authors.initials: L
authors.lastname: Mondragón
authors.forename: Andrea
authors.initials: A
authors.lastname: Bernardos
authors.forename: Ramón
authors.initials: R
authors.lastname: Martínez-Máñez
authors.forename: M Dolores
authors.initials: MD
authors.lastname: Marcos
authors.forename: Félix
authors.initials: F
authors.lastname: Sancenón
authors.forename: Juan
authors.initials: J
authors.lastname: Soto
authors.forename: Ana
authors.initials: A
authors.lastname: Costero
authors.forename: Cristina
authors.initials: C
authors.lastname: Manguan-García
authors.forename: Rosario
authors.initials: R
authors.lastname: Perona
authors.forename: Marta
authors.initials: M
authors.lastname: Moreno-Torres
authors.forename: Rafael
authors.initials: R
authors.lastname: Aparicio-Sanchis
authors.forename: José Ramón
authors.initials: JR
authors.lastname: Murguía
mesh_terms: D045744:Cell Line, Tumor; D016922:Cellular Senescence; D016503:Drug Delivery Systems / Q000295:instrumentation / Q000379:methods*; D005456:Fluorescent Dyes / Q000008:administration & dosage / Q000737:chemistry; D006801:Humans; D053758:Nanoparticles / Q000737:chemistry*; D016062:Porosity; D012235:Rhodamines / Q000008:administration & dosage / Q000737:chemistry; D012822:Silicon Dioxide / Q000737:chemistry*; D001616:beta-Galactosidase / Q000737:chemistry / Q000378:metabolism
chemical_list: D005456:Fluorescent Dyes; D012235:Rhodamines; D012822:Silicon Dioxide; D001616:beta-Galactosidase; C029773:rhodamine B