title: Levetiracetam-associated aggravation of myoclonic seizure in children.
abstract: Some antiepileptic drugs (AEDs) have been reported to aggravate generalized seizures. We have seen three children whose myoclonic seizures increased on starting treatment with Levetiracetam. In all seizures aggravation was temporally associated to the introduction of the drug. All became seizure-free on withdrawal of levetiracetam with a switch to an alternative antiepileptic drug and this persisted for at least 6 months. This suggests that some children with myoclonic seizures may have an aggravation on starting treatment with levetiracetam but this requires further studies.
authors.affiliation: Department of Neurology, Xijing Hospital, Fourth Military Medical University, Xi'an 710032, PR China. liuyhong@fmmu.edu.cn
authors.forename: Yong-Hong
authors.initials: YH
authors.lastname: Liu
authors.forename: Xiao-Li
authors.initials: XL
authors.lastname: Wang
authors.forename: Yan-Chun
authors.initials: YC
authors.lastname: Deng
authors.forename: Gang
authors.initials: G
authors.lastname: Zhao
mesh_terms: D000927:Anticonvulsants / Q000009:adverse effects* / Q000627:therapeutic use; D002648:Child; D004569:Electroencephalography; D004831:Epilepsies, Myoclonic / Q000188:drug therapy*; D006801:Humans; D000077287:Levetiracetam; D008297:Male; D010889:Piracetam / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000627:therapeutic use
chemical_list: D000927:Anticonvulsants; D000077287:Levetiracetam; D010889:Piracetam