title: Chemistry of the nudibranch Aldisa andersoni: structure and biological activity of phorbazole metabolites.
abstract: The first chemical study of the Indo-Pacific dorid nudibranch Aldisa andersoni resulted in the isolation of five chlorinated phenyl-pyrrolyloxazoles belonging to the phorbazole series. Two new molecules, 9-chloro-phorbazole D and N1-methyl-phorbazole A, co-occurring with known phorbazoles A, B and D, have been characterized. Phorbazoles were found to be present mainly in the external part of the mollusc. The structures of the new compounds were determined by interpretation of spectroscopic data, mainly NMR and mass spectrometry and by comparison with the literature data. Evaluation of feeding-deterrence activity as well as in vitro growth inhibitory properties in human cancer cells was also carried out.
authors.affiliation: CNR, Instituto di Chimica Biomolecolare, Via Campi Flegrei 34, I-80078 Pozzuoli, Naples, Italy.
authors.forename: Genoveffa
authors.initials: G
authors.lastname: Nuzzo
authors.affiliation: CNR, Instituto di Chimica Biomolecolare, Via Campi Flegrei 34, I-80078 Pozzuoli, Naples, Italy.
authors.forename: Maria Letizia
authors.initials: ML
authors.lastname: Ciavatta
authors.affiliation: Laboratoire de Toxicologie, Faculté de Pharmacie, Université Libre de Bruxelles (ULB), Campus de la Plaine, Boulevard du Triomphe, 1050, Brussels, Belgium.
authors.forename: Robert
authors.initials: R
authors.lastname: Kiss
authors.affiliation: Laboratoire de Toxicologie, Faculté de Pharmacie, Université Libre de Bruxelles (ULB), Campus de la Plaine, Boulevard du Triomphe, 1050, Brussels, Belgium.
authors.forename: Véronique
authors.initials: V
authors.lastname: Mathieu
authors.affiliation: Laboratoire de Toxicologie, Faculté de Pharmacie, Université Libre de Bruxelles (ULB), Campus de la Plaine, Boulevard du Triomphe, 1050, Brussels, Belgium.
authors.forename: Helene
authors.initials: H
authors.lastname: Leclercqz
authors.affiliation: CNR, Instituto di Chimica Biomolecolare, Via Campi Flegrei 34, I-80078 Pozzuoli, Naples, Italy.
authors.forename: Emiliano
authors.initials: E
authors.lastname: Manzo
authors.affiliation: CNR, Instituto di Chimica Biomolecolare, Via Campi Flegrei 34, I-80078 Pozzuoli, Naples, Italy.
authors.forename: Guido
authors.initials: G
authors.lastname: Villani
authors.affiliation: CNR, Instituto di Chimica Biomolecolare, Via Campi Flegrei 34, I-80078 Pozzuoli, Naples, Italy.
authors.forename: Ernesto
authors.identifier: 0000-0001-7379-1788
authors.initials: E
authors.lastname: Mollo
authors.affiliation: Service de Neurochirurgie, Hôpital Erasme, ULB, Route de Lennik, 1070 Brussels, Belgium.
authors.forename: Florence
authors.initials: F
authors.lastname: Lefranc
authors.affiliation: CSIR-National Institute of Oceanography, 403 004 Dona Paula, Goa, India.
authors.forename: Lisette
authors.initials: L
authors.lastname: D'Souza
authors.affiliation: CNR, Instituto di Chimica Biomolecolare, Via Campi Flegrei 34, I-80078 Pozzuoli, Naples, Italy.
authors.forename: Margherita
authors.initials: M
authors.lastname: Gavagnin
authors.affiliation: CNR, Instituto di Chimica Biomolecolare, Via Campi Flegrei 34, I-80078 Pozzuoli, Naples, Italy.
authors.forename: Guido
authors.initials: G
authors.lastname: Cimino
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D045744:Cell Line, Tumor; D049851:Gastropoda / Q000737:chemistry*; D006801:Humans; D019156:Indian Ocean; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D010080:Oxazoles / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D013329:Structure-Activity Relationship
chemical_list: D000970:Antineoplastic Agents; D010080:Oxazoles