title: [Preclinical study of anxiolytic activity and safety of Racium phytomedicine].
abstract: Results of a preclinical study of the anxiolytic activity and safety of original Racium phytomedicine are presented. The preparation possessed high anxiolytic activity, exhibits a wide range of therapeutic effects, produces no lethality in male and female rats and mice upon single intragastric and intraperitoneal introduction in doses up to 5 g/kg (VI class of toxicity according to OECD), induces no pathologic effects upon prolonged (120 days) administration in these rodents, and has no local irritant and/or allergen action.
authors.forename: E V
authors.initials: EV
authors.lastname: Kravchenko
authors.forename: V M
authors.initials: VM
authors.lastname: Nasek
authors.forename: I V
authors.initials: IV
authors.lastname: Ponteleeva
authors.forename: M V
authors.initials: MV
authors.lastname: Mazhar
authors.forename: E Iu
authors.initials: EIu
authors.lastname: Sholomitskaia
authors.forename: I A
authors.initials: IA
authors.lastname: Zhukova
authors.forename: E V
authors.initials: EV
authors.lastname: San'ko
authors.forename: O V
authors.initials: OV
authors.lastname: Veselukha
authors.forename: A S
authors.initials: AS
authors.lastname: Nekhai
authors.forename: E V
authors.initials: EV
authors.lastname: Shafranovskaia
authors.forename: I V
authors.initials: IV
authors.lastname: Zhebrakova
mesh_terms: D000818:Animals; D014151:Anti-Anxiety Agents / Q000008:administration & dosage / Q000737:chemistry / Q000627:therapeutic use*; D001007:Anxiety / Q000188:drug therapy* / Q000503:physiopathology / Q000523:psychology; D002851:Chromatography, High Pressure Liquid; D004305:Dose-Response Relationship, Drug; D004353:Drug Evaluation, Preclinical; D064420:Drug-Related Side Effects and Adverse Reactions; D005260:Female; D007274:Injections, Intraperitoneal; D007441:Intubation, Gastrointestinal; D007928:Lethal Dose 50; D008297:Male; D031334:Melissa / Q000737:chemistry*; D036142:Mentha piperita / Q000737:chemistry*; D051379:Mice; D008517:Phytotherapy; D010936:Plant Extracts / Q000008:administration & dosage / Q000737:chemistry / Q000627:therapeutic use*; D051381:Rats; D012717:Sesquiterpenes / Q000032:analysis; D014632:Valerian / Q000737:chemistry*
chemical_list: D014151:Anti-Anxiety Agents; D010936:Plant Extracts; D012717:Sesquiterpenes