title: A fluorescent probe capable of detecting H2S at submicromolar concentrations in cells.
abstract: A new internal charge transfer (ICT) fluorescent probe for highly selective and sensitive monitoring of H(2)S has been developed. The design takes advantage of the facile reduction of non-fluorescent hydroxyamine naphthalimide by H(2)S to highly fluorescent amine naphthalimide. It has been demonstrated that the probe is able to detect H(2)S at submicromolar concentrations in cells.
authors.affiliation: Department of Chemistry & Chemical Biology, University of New Mexico, MSC03 2060, Albuquerque, NM 87131-0001, USA.
authors.forename: Weimin
authors.initials: W
authors.lastname: Xuan
authors.forename: Rong
authors.initials: R
authors.lastname: Pan
authors.forename: Yanting
authors.initials: Y
authors.lastname: Cao
authors.forename: Kejian
authors.initials: K
authors.lastname: Liu
authors.forename: Wei
authors.initials: W
authors.lastname: Wang
mesh_terms: D000818:Animals; D002460:Cell Line; D005456:Fluorescent Dyes / Q000737:chemistry*; D006575:Heterocyclic Compounds, 3-Ring / Q000737:chemistry*; D006862:Hydrogen Sulfide / Q000032:analysis*; D008670:Metals / Q000737:chemistry; D051379:Mice; D018613:Microscopy, Confocal; D017382:Reactive Oxygen Species / Q000737:chemistry
chemical_list: D005456:Fluorescent Dyes; D006575:Heterocyclic Compounds, 3-Ring; D008670:Metals; D017382:Reactive Oxygen Species; D006862:Hydrogen Sulfide