title: Development and use of TCR transgenic mice for malaria immunology research.
abstract: T-cell receptor transgenic mice are powerful tools to study T cell responses to malaria parasites. They allow for a population of antigen specific T cells to be monitored during developing responses to immunization or parasite infection; this makes them particularly useful to study fundamental aspects of T cell activation, differentiation, and migration in different tissue compartments. Moreover, the use of these cells allows for a thorough analysis of the mechanisms of antiparasite activity by T cells.
authors.affiliation: Department of Molecular Microbiology and Immunology, John Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
authors.forename: Yun-Chi
authors.initials: YC
authors.lastname: Chen
authors.forename: Fidel
authors.initials: F
authors.lastname: Zavala
mesh_terms: D000818:Animals; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology; D018390:Gene Targeting / Q000379:methods; D005822:Genetic Vectors / Q000235:genetics; D008288:Malaria / Q000276:immunology* / Q000469:parasitology*; D051379:Mice; D008822:Mice, Transgenic; D010961:Plasmodium / Q000254:growth & development / Q000276:immunology; D011948:Receptors, Antigen, T-Cell / Q000235:genetics* / Q000276:immunology*; D019076:Transgenes
chemical_list: D011948:Receptors, Antigen, T-Cell