title: Elaiomycins D-F, antimicrobial and cytotoxic azoxides from Streptomyces sp. strain HKI0708.
abstract: Five new congeners of elaiomycin featuring the rare azoxy function were isolated from Streptomyces sp. strain HKI0708. Individual elaiomycins exhibit specific antimycobacterial, anti-Aspergillus, and cytotoxic activities, providing provisional data on structure-activity relationships. The co-occurrence of the azoxide variants indicates a biogenetic relationship that illustrates new diversification steps in elaiomycin biosynthesis.
authors.affiliation: Leibniz Institute for Natural Product Research and Infection Biology,  Hans Knöll Institute  (HKI), Beutenbergstraße 11a, 07745 Jena, Germany.
authors.forename: Ling
authors.initials: L
authors.lastname: Ding
authors.forename: Basile Le Sage Tchize
authors.initials: Ble S
authors.lastname: Ndejouong
authors.forename: Armin
authors.initials: A
authors.lastname: Maier
authors.forename: Heinz-Herbert
authors.initials: HH
authors.lastname: Fiebig
authors.forename: Christian
authors.initials: C
authors.lastname: Hertweck
mesh_terms: D000900:Anti-Bacterial Agents / Q000302:isolation & purification / Q000494:pharmacology; D000890:Anti-Infective Agents / Q000302:isolation & purification / Q000494:pharmacology; D001230:Aspergillus / Q000187:drug effects; D001391:Azo Compounds / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D006801:Humans; D008826:Microbial Sensitivity Tests; D009161:Mycobacterium / Q000187:drug effects; D013237:Stereoisomerism; D013302:Streptomyces / Q000737:chemistry* / Q000235:genetics; D013329:Structure-Activity Relationship
chemical_list: D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents; D001391:Azo Compounds; C013979:elaiomycin