title: [Hereditary optic neuropathies].
abstract: Hereditary optic neuropathies are a group of heterogeneous conditions affecting both optic nerves, with an autosomal dominant, autosomal recessive, X-related or mitochondrial transmission. The two most common non-syndromic hereditary optic neuropathies (Leber's hereditary optic neuropathy and autosomal dominant optic atrophy) are very different in their clinical presentation and their genetic transmission, leading however to a common, non-specific optic nerve atrophy. Beyond the optic atrophy-related visual loss, which is the clinical hallmark of this group of diseases, other associated neurological signs are increasingly recognized.
authors.affiliation: Ophthalmologie, CHU d'Angers, 4, rue Larrey, 49000 Angers, France. damilea@chu-angers.fr
authors.forename: D
authors.initials: D
authors.lastname: Milea
authors.forename: C
authors.initials: C
authors.lastname: Verny
mesh_terms: D006801:Humans; D015418:Optic Atrophies, Hereditary / Q000175:diagnosis / Q000453:epidemiology / Q000235:genetics; D029241:Optic Atrophy, Autosomal Dominant / Q000175:diagnosis / Q000453:epidemiology / Q000235:genetics; D029242:Optic Atrophy, Hereditary, Leber / Q000175:diagnosis / Q000453:epidemiology / Q000235:genetics; D009901:Optic Nerve Diseases / Q000145:classification / Q000175:diagnosis* / Q000453:epidemiology / Q000235:genetics*; D013577:Syndrome