title: I-motif formation in gene promoters: unusually stable formation in sequences complementary to known G-quadruplexes.
abstract: I-motif formation has been confirmed in a number of gene promoter sequences known to form G-quadruplex structures. I-motif formation can occur close to physiological temperature and pH for h-tert and PDGF-A. The i-motif structure formed by a HIF-1α promoter sequence shows unexpected stability near neutral pH.
authors.affiliation: School of Pharmacy, University of Reading, Whiteknights, Reading, Berks, RG6 6AD. j.a.brazier@reading.ac.uk
authors.forename: John A
authors.initials: JA
authors.lastname: Brazier
authors.forename: Arti
authors.initials: A
authors.lastname: Shah
authors.forename: Geoffrey D
authors.initials: GD
authors.lastname: Brown
mesh_terms: D001483:Base Sequence; D054856:G-Quadruplexes; D006863:Hydrogen-Ion Concentration; D051795:Hypoxia-Inducible Factor 1, alpha Subunit / Q000235:genetics; D008969:Molecular Sequence Data; D059372:Nucleotide Motifs; D009841:Oligonucleotides / Q000235:genetics*; D011401:Promoter Regions, Genetic / Q000235:genetics*; D013696:Temperature
chemical_list: D051795:Hypoxia-Inducible Factor 1, alpha Subunit; D009841:Oligonucleotides