title: Comparing the effects of salts of diclofenac and alminoprofen with aspirin on serum electrolytes, creatinine and urea levels in rabbits.
abstract: The effects of diclofenac sodium, diclofenac potassium, alminoprofen and aspirin on serum electrolytes (serum Na(+) and K(+)), urea and creatinine were compared in rabbits in acute and chronic phases of treatment. The data suggested that all the four drugs markedly increased the serum electrolytes, urea and creatinine levels in both post-treatment phases. In conclusion, present study does not present any advantage of diclofenac sodium over diclofenac potassium at electrolyte levels on short and long term treatment. Nevertheless, current data support the evidence of renal function impairment by all the four drug therapies used in the present study, which is generally caused by NSAIDS.
authors.affiliation: University College of Pharmacy, University of the Punjab, Lahore, Pakistan. snihusain@yahoo.com
authors.forename: Nawazish-I-Husain
authors.initials: NI
authors.lastname: Syed
authors.forename: Farnaz
authors.initials: F
authors.lastname: Zehra
authors.forename: Amir Ali-Rizvi
authors.initials: AA
authors.lastname: Syed
authors.forename: Sabiha
authors.initials: S
authors.lastname: Karim
authors.forename: Farrakh Zia
authors.initials: FZ
authors.lastname: Khan
mesh_terms: D000284:Administration, Oral; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology* / Q000633:toxicity; D001241:Aspirin / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology* / Q000633:toxicity; D002626:Chemistry, Pharmaceutical; D003404:Creatinine / Q000097:blood*; D004008:Diclofenac / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology* / Q000633:toxicity; D004573:Electrolytes / Q000097:blood*; D005260:Female; D007668:Kidney / Q000187:drug effects* / Q000378:metabolism; D008297:Male; D011422:Propionates / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology* / Q000633:toxicity; D011817:Rabbits; D013997:Time Factors; D014508:Urea / Q000097:blood*
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D004573:Electrolytes; D011422:Propionates; C027953:alminoprofen; D004008:Diclofenac; D014508:Urea; D003404:Creatinine; D001241:Aspirin