title: IL-1β a potential factor for discriminating between thyroid carcinoma and atrophic thyroiditis.
abstract: Interactions between cytokines and others soluble factors (hormones, antibodies...) can play an important role in the development of thyroid pathogenesis. The purpose of the present study was to examine the possible correlation between serum cytokine concentrations, thyroid hormones (FT4 and TSH) and auto-antibodies (Tg and TPO), and their usefulness in discriminating between different thyroid conditions. In this study, we investigated serum from 115 patients affected with a variety of thyroid conditions (44 Graves' disease, 17 Hashimoto's thyroiditis, 11 atrophic thyroiditis, 28 thyroid nodular goitre and 15 papillary thyroid cancer), and 30 controls. Levels of 17 cytokines in serum samples were measured simultaneously using a multiplexed human cytokine assay. Thyroid hormones and auto-antibodies were measured using ELISA. Our study showed that IL-1β serum concentrations allow the discrimination between atrophic thyroiditis and papillary thyroid cancer groups (p = 0.027).
authors.affiliation: LIA135 CNRS. kammounmaha@yahoo.fr
authors.forename: Maha
authors.initials: M
authors.lastname: Kammoun-Krichen
authors.forename: Noura
authors.initials: N
authors.lastname: Bougacha-Elleuch
authors.forename: Mouna
authors.initials: M
authors.lastname: Mnif
authors.forename: Fadia
authors.initials: F
authors.lastname: Bougacha
authors.forename: Ilhem
authors.initials: I
authors.lastname: Charffedine
authors.forename: Sandra
authors.initials: S
authors.lastname: Rebuffat
authors.forename: Ahmed
authors.initials: A
authors.lastname: Rebai
authors.forename: Emilie
authors.initials: E
authors.lastname: Glasson
authors.forename: Mohamed
authors.initials: M
authors.lastname: Abid
authors.forename: Fatma
authors.initials: F
authors.lastname: Ayadi
authors.forename: Sylvie
authors.initials: S
authors.lastname: Péraldi-Roux
authors.forename: Hammadi
authors.initials: H
authors.lastname: Ayadi
mesh_terms: D001284:Atrophy; D001323:Autoantibodies / Q000276:immunology; D016022:Case-Control Studies; D003937:Diagnosis, Differential; D006801:Humans; D053583:Interleukin-1beta / Q000097:blood*; D013961:Thyroid Gland / Q000473:pathology*; D013963:Thyroid Hormones / Q000097:blood; D013964:Thyroid Neoplasms / Q000097:blood / Q000175:diagnosis* / Q000276:immunology; D013966:Thyroiditis / Q000097:blood / Q000175:diagnosis* / Q000276:immunology
chemical_list: D001323:Autoantibodies; D053583:Interleukin-1beta; D013963:Thyroid Hormones