title: Immune response during interferon beta-1b treatment in patients with multiple sclerosis who experienced relapses and those who were relapse-free in the START study.
abstract: We measured immune markers in subjects with multiple sclerosis (MS) treated with IFNβ-1b for 12 months. IL-17 levels were significantly higher at Month 6 (p=0.036) in relapsing subjects while BDNF levels were significantly higher at Month 3 (p=0.028) in relapse-free subjects. Change from baseline in IL-4 levels inversely correlated with disability score whereas change from baseline in IL-10/IFN-gamma ratio inversely correlated with occurrence of relapses. CXCR3+CD8+ T-cells tended to be higher but declined with treatment in relapse-free compared with relapsing subjects. Findings show the potential of cytokine and neurotrophic factors as biomarkers of clinical response to IFNβ-1b.
authors.affiliation: UMDNJ-Robert Wood Johnson Medical School, New Brunswick, NJ 08901, USA. jalbutsu@umdnj.edu
authors.forename: Suhayl
authors.initials: S
authors.lastname: Dhib-Jalbut
authors.forename: Sumandeep
authors.initials: S
authors.lastname: Sumandeep
authors.forename: Reuben
authors.initials: R
authors.lastname: Valenzuela
authors.forename: Kouichi
authors.initials: K
authors.lastname: Ito
authors.forename: Payal
authors.initials: P
authors.lastname: Patel
authors.forename: Mark
authors.initials: M
authors.lastname: Rametta
mesh_terms: D000026:Abortion, Habitual / Q000517:prevention & control; D000276:Adjuvants, Immunologic / Q000627:therapeutic use*; D000293:Adolescent; D000328:Adult; D016207:Cytokines / Q000378:metabolism*; D004185:Disability Evaluation; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D000068576:Interferon beta-1b; D016899:Interferon-beta / Q000627:therapeutic use*; D008297:Male; D020778:Matrix Metalloproteinase 2 / Q000378:metabolism; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000188:drug therapy* / Q000276:immunology*; D019716:Tissue Inhibitor of Metalloproteinase-2 / Q000378:metabolism; D019010:Vascular Cell Adhesion Molecule-1 / Q000378:metabolism; D055815:Young Adult
chemical_list: D000276:Adjuvants, Immunologic; D016207:Cytokines; D019010:Vascular Cell Adhesion Molecule-1; D019716:Tissue Inhibitor of Metalloproteinase-2; D000068576:Interferon beta-1b; D016899:Interferon-beta; D020778:Matrix Metalloproteinase 2