title: Hydrogen bonding directed intermolecular Cope-type hydroamination of alkenes.
abstract: Intermolecular hydroamination of unactivated alkenes represents a significant synthetic challenge. An efficient Cope-type hydroamination is achieved under mild conditions for reactions of N-alkylhydroxylamines with allylic amines, using hydrogen bonding to achieve increased reactivity and high regioselectivity. This approach provides a number of highly functionalized vicinal diamine motifs as Markovnikov addition products.
authors.affiliation: Center for Catalysis Research and Innovation, Department of Chemistry, University of Ottawa, 10 Marie Curie, Ottawa, Ontario, Canada K1N 6N5.
authors.forename: Shu-Bin
authors.initials: SB
authors.lastname: Zhao
authors.forename: Eric
authors.initials: E
authors.lastname: Bilodeau
authors.forename: Valérie
authors.initials: V
authors.lastname: Lemieux
authors.forename: André M
authors.initials: AM
authors.lastname: Beauchemin
mesh_terms: D000475:Alkenes / Q000737:chemistry*; D000586:Amination; D006859:Hydrogen / Q000737:chemistry; D006860:Hydrogen Bonding; D015394:Molecular Structure; D010084:Oxidation-Reduction
chemical_list: D000475:Alkenes; D006859:Hydrogen