title: Thyroid abnormalities in children and adolescents with McCune-Albright syndrome.
abstract: BACKGROUND
  To date, there is no agreement about the frequency or the features of thyroid abnormalities in McCune-Albright syndrome (MAS). The aim of our study was to detect thyroid abnormalities in a cohort of MAS children and adolescents and to give indications for their treatment and follow-up.
  
  
  METHODS
  In 36 patients, 22 females and 14 males, thyroid function and sonographic features of thyroid were evaluated every 6-12 months.
  
  
  RESULTS
  Three males and 1 female had hyperthyroidism: 2 with nodular, 2 with diffuse goiters. They were treated with methimazole (0.2-0.5 mg/kg/day) with good clinical and biochemical responses. The remaining 32 patients were euthyroid, even if 7 displayed sonographic alterations, of whom 5 had nodular goiter with nodules >1 cm, and 2 micronodular goiter. Fine-needle aspiration biopsy was performed in 2 patients with nodules >1 cm, 1 showing hemorrhagic nodule and 1 colloid cystic nodule.
  
  
  CONCLUSIONS
  Prevalence of thyroid alterations in the studied MAS series was 31%. 64% of 11 patients with thyroid alterations had nodular goiters, with nodules >1 cm. As the onset of thyroid disease ranged from 1 to 20 years, a strict monitoring of thyroid function is recommended every 6 months. Satisfactory treatment can be obtained and maintained with antithyroid drugs.
authors.affiliation: Departments of Pediatric Endocrinology and Diabetology, University of Turin, Regina Margherita Children's Hospital, Turin, Italy.
authors.forename: D
authors.initials: D
authors.lastname: Tessaris
authors.forename: A
authors.initials: A
authors.lastname: Corrias
authors.forename: P
authors.initials: P
authors.lastname: Matarazzo
authors.forename: L
authors.initials: L
authors.lastname: De Sanctis
authors.forename: M
authors.initials: M
authors.lastname: Wasniewska
authors.forename: M F
authors.initials: MF
authors.lastname: Messina
authors.forename: M C
authors.initials: MC
authors.lastname: Vigone
authors.forename: R
authors.initials: R
authors.lastname: Lala
mesh_terms: D000293:Adolescent; D000328:Adult; D013956:Antithyroid Agents / Q000008:administration & dosage*; D002648:Child; D002675:Child, Preschool; D005260:Female; D005359:Fibrous Dysplasia, Polyostotic / Q000150:complications / Q000188:drug therapy / Q000453:epidemiology / Q000378:metabolism; D005500:Follow-Up Studies; D006801:Humans; D007223:Infant; D008297:Male; D008713:Methimazole / Q000008:administration & dosage*; D015995:Prevalence; D012189:Retrospective Studies; D013959:Thyroid Diseases / Q000150:complications / Q000188:drug therapy / Q000453:epidemiology / Q000378:metabolism; D013961:Thyroid Gland / Q000378:metabolism* / Q000473:pathology
chemical_list: D013956:Antithyroid Agents; D008713:Methimazole