title: Intrinsic temperature sensitivity of influenza C virus hemagglutinin-esterase-fusion protein.
abstract: Influenza C virus replicates more efficiently at 33°C than at 37°C. To determine whether hemagglutinin-esterase-fusion protein (HEF), a surface glycoprotein of influenza C virus, is a restricting factor for this temperature sensitivity, we analyzed the biological and biochemical properties of HEF at 33°C and 37°C. We found that HEF exhibits intrinsic temperature sensitivities for surface expression and fusion activity.
authors.affiliation: Influenza Virus Research Center, National Institute of Infectious Diseases, Musashimurayama, Tokyo, Japan. emitaka@nih.go.jp
authors.forename: Emi
authors.initials: E
authors.lastname: Takashita
authors.forename: Yasushi
authors.initials: Y
authors.lastname: Muraki
authors.forename: Kanetsu
authors.initials: K
authors.lastname: Sugawara
authors.forename: Hironobu
authors.initials: H
authors.lastname: Asao
authors.forename: Hidekazu
authors.initials: H
authors.lastname: Nishimura
authors.forename: Koji
authors.initials: K
authors.lastname: Suzuki
authors.forename: Takashi
authors.initials: T
authors.lastname: Tsuji
authors.forename: Seiji
authors.initials: S
authors.lastname: Hongo
authors.forename: Yoshiro
authors.initials: Y
authors.lastname: Ohara
authors.forename: Yoshihiro
authors.initials: Y
authors.lastname: Ohara
authors.forename: Yoshihiro
authors.initials: Y
authors.lastname: Kawaoka
authors.forename: Makoto
authors.initials: M
authors.lastname: Ozawa
authors.forename: Yoko
authors.initials: Y
authors.lastname: Matsuzaki
mesh_terms: D000818:Animals; D019556:COS Cells; D002522:Chlorocebus aethiops; D004591:Electrophoresis, Polyacrylamide Gel; D004950:Esterases / Q000378:metabolism*; D006389:Hemagglutinins, Viral / Q000378:metabolism*; D047468:Immunoprecipitation; D009982:Gammainfluenzavirus / Q000378:metabolism* / Q000502:physiology; D013696:Temperature; D014760:Viral Fusion Proteins / Q000378:metabolism*; D014779:Virus Replication / Q000502:physiology
chemical_list: D006389:Hemagglutinins, Viral; D014760:Viral Fusion Proteins; D004950:Esterases