title: [Correlation of the expressions of MMPs-9, TIMP-1 and TIMP-2 with cesarean section scar].
abstract: OBJECTIVE
  To investigate the roles of MMPs-9, TIMP-1 and TIMP-2 in cesarean section scar healing.
  
  
  METHODS
  The expressions of the MMPs-9, TIMP-1 and TIMP-2 were detected by EnVision immunohistochemistry in 22 pregnant women with serious complications of the uterine scar, including 8 with early caesarean scar pregnancy (CSP) and 14 with full-term pregnancy undergoing hysterectomy for placenta previa or implanted placenta. Thirty-eight full-term pregnant women without serious complications of the uterine scar and 32 normal full-term pregnant women served as the control I and control II groups, respectively.
  
  
  RESULTS
  The expressions of MMPs-9 and TIMP-1 differed significantly between the 3 groups (P<0.05), whereas TIMP-2 did not (P>0.05). Spearman rank correlation analysis showed that the expression of MMPs-9 in the uterine scar tissues was positively correlated with poor uterine scar healing with the correlation coefficients of 0.309 and 0.643. An increased severity of poor healing scar was associated with a significantly increased expression of MMPs-9 (P<0.05).
  
  
  CONCLUSIONS
  The imbalanced expressions of MMPs-9 and TIMP-1 in injury repair can be related to poor uterine scar healing and CSP.
authors.affiliation: Department of Obstetrics and Gynecology, Third Affiliated Hospital of Southern Medical University, Guangzhou 510630, China. cherrydoc@126.com
authors.forename: Qiong
authors.initials: Q
authors.lastname: Li
authors.forename: Suiqun
authors.initials: S
authors.lastname: Guo
authors.forename: Dalie
authors.initials: D
authors.lastname: Liu
authors.forename: Shuying
authors.initials: S
authors.lastname: Feng
authors.forename: Qingzhu
authors.initials: Q
authors.lastname: Wei
mesh_terms: D000328:Adult; D002585:Cesarean Section / Q000009:adverse effects; D002921:Cicatrix / Q000209:etiology / Q000378:metabolism*; D005260:Female; D006801:Humans; D020780:Matrix Metalloproteinase 9 / Q000378:metabolism*; D010923:Placenta Previa / Q000601:surgery; D011247:Pregnancy; D019715:Tissue Inhibitor of Metalloproteinase-1 / Q000378:metabolism*; D019716:Tissue Inhibitor of Metalloproteinase-2 / Q000378:metabolism*; D014599:Uterus / Q000473:pathology; D014945:Wound Healing; D055815:Young Adult
chemical_list: C560822:TIMP1 protein, human; C560823:TIMP2 protein, human; D019715:Tissue Inhibitor of Metalloproteinase-1; D019716:Tissue Inhibitor of Metalloproteinase-2; C579270:MMP9 protein, human; D020780:Matrix Metalloproteinase 9