title: Prevention of peritendinous adhesions with electrospun ibuprofen-loaded poly(L-lactic acid)-polyethylene glycol fibrous membranes.
abstract: Physical barriers are commonly used to reduce peritendinous adhesion after injury. However, the inflammatory response to surgery cannot be prevented. This study was designed to evaluate the ability of ibuprofen-loaded poly(l-lactic acid)-polyethylene glycol (PELA) diblock copolymer fibrous membranes in preventing adhesion formation and reduce inflammation. Electrospun PELA fibrous membranes underwent mechanical testing and were characterized by morphology, surface wettability, drug release, and degradation. Results of an in vitro drug release study showed that a burst release was followed by sustained release from fibrous membranes with high initial ibuprofen content. Fewer L929 mouse fibroblasts adhered to and proliferated on the ibuprofen-loaded PELA fibrous membrane compared with tissue culture plates or PELA fibrous membrane without ibuprofen. In a chicken model of flexor digitorum profundus tendon surgery, the ibuprofen-loaded PELA fibrous membranes prevented tissue adhesion and significantly reduced inflammation. Taken together, these results demonstrate that ibuprofen-loaded PELA fibrous membranes prevent peritendinous adhesion formation better than membranes that do not contain ibuprofen, through anti-adhesion and anti-inflammatory actions.
authors.affiliation: Department of Orthopaedics, Shanghai Sixth People's Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, P.R. China.
authors.forename: Shen
authors.initials: S
authors.lastname: Liu
authors.forename: Changmin
authors.initials: C
authors.lastname: Hu
authors.forename: Fengfeng
authors.initials: F
authors.lastname: Li
authors.forename: Xu-jun
authors.initials: XJ
authors.lastname: Li
authors.forename: Wenguo
authors.initials: W
authors.lastname: Cui
authors.forename: Cunyi
authors.initials: C
authors.lastname: Fan
mesh_terms: D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage / Q000737:chemistry; D001458:Bandages; D002645:Chickens; D004058:Diffusion; D004343:Drug Implants / Q000008:administration & dosage* / Q000138:chemical synthesis; D004563:Electrochemistry / Q000379:methods; D007052:Ibuprofen / Q000008:administration & dosage* / Q000737:chemistry; D019344:Lactic Acid / Q000737:chemistry; D008567:Membranes, Artificial; D011091:Polyesters; D020959:Polyethylene / Q000737:chemistry; D011108:Polymers / Q000737:chemistry; D016062:Porosity; D012399:Rotation; D058971:Tenotomy / Q000009:adverse effects*; D000267:Tissue Adhesions / Q000209:etiology* / Q000517:prevention & control*; D016896:Treatment Outcome
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D004343:Drug Implants; D008567:Membranes, Artificial; D011091:Polyesters; D011108:Polymers; D019344:Lactic Acid; C033616:poly(lactide); D020959:Polyethylene; D007052:Ibuprofen