title: Castleman disease in a child with short stature.
abstract: We report a 14-year-old boy with Castleman disease in this article. He complained of short stature, and his body height was 133.8 cm (<3rd percentile; z score -4.5). There was marked delay in the appearance of secondary sexual characteristics. He was found to have a remittent fever and a lower mid-abdominal tumor. Blood test revealed microcytic hypochromic anemia, thrombocytosis, polyclonal hypergammaglobulinemia, hyperfibrinogenemia, and elevated erythrocyte sedimentation rate. The serum IL-6 and C-reactive protein levels were increased. The mass was found to be mixed hyaline vascular and plasma cell type of Castleman disease through a pathological examination. Lymph nodes affected by Castleman disease cause overproduction of IL-6. It decreases IGF-1, IGFBP-3 and serum testosterone levels. As a result of tumorectomy, his short stature and delay in the development of secondary sexual characteristics were improved.
authors.affiliation: Department of Multidisciplinary Internal Medicine, Division of Pediatrics and Perinatology, Tottori University Faculty of Medicine, Yonago, Japan.
authors.forename: Takuya
authors.initials: T
authors.lastname: Hanada
authors.forename: Keisuke
authors.initials: K
authors.lastname: Okuno
authors.forename: Shin-ichi
authors.initials: S
authors.lastname: Okada
authors.forename: Masanobu
authors.initials: M
authors.lastname: Fujimoto
authors.forename: Hiroki
authors.initials: H
authors.lastname: Kuranobu
authors.forename: Yuichiro
authors.initials: Y
authors.lastname: Hashida
authors.forename: Jun-ichi
authors.initials: J
authors.lastname: Ueyama
authors.forename: Jun
authors.initials: J
authors.lastname: Murakami
authors.forename: Atsushi
authors.initials: A
authors.lastname: Hayashi
authors.forename: Keiichi
authors.initials: K
authors.lastname: Hanaki
authors.forename: Susumu
authors.initials: S
authors.lastname: Kanzaki
mesh_terms: D000293:Adolescent; D005871:Castleman Disease / Q000150:complications* / Q000175:diagnosis / Q000473:pathology; D004392:Dwarfism / Q000209:etiology*; D006801:Humans; D008198:Lymph Nodes / Q000378:metabolism / Q000473:pathology*; D008297:Male; D011628:Puberty, Delayed / Q000209:etiology*