title: [Effects of propofol and ketamine on postoperative hepatic and renal function: comparison between fentanyl and remifentanil as an adjuvant].
abstract: BACKGROUND
  The aim of this study was to assess the effects of two different opioids, fentanyl and remifentanil, as an adjuvant in propofol-ketamine based total intravenous anesthesia (PFK and PRK) on post-anesthetic hepatic and renal function.
  
  
  METHODS
  We conducted a review of patients undergoing total or subtotal esophagectomy over a 2-year period, in which pre- and post-anesthesia values of seven hepatic function tests, aspartate aminotransferase, alanine aminotransferase, lactate dehydrogenase, alkaline phosphatase, gamma glutamyl-transpeptidase, total bilirubin, prothrombin time-international normalized ratio, and two renal function tests, blood urea nitrogen, as well as serum creatinine, were evaluated.
  
  
  RESULTS
  Total numbers of patients in PFK or PRK were 51 and 18, respectively. In PRK group, duration of surgery was longer than that in PFK group, 537 +/- 155 and 453 +/- 67 (min, mean +/- SD), respectively. More patients in PRK group required blood transfusion compared with PFK group. There was no significant interaction between any hepatic or renal function test and anesthesia. In addition, there was no significant difference of increasing rates in hepatic and renal function tests between PFK and PRK.
  
  
  CONCLUSIONS
  The hepatic and renal function after esophagectomy was comparable between PFK and PRK.
authors.affiliation: Department of Emergency and Disaster Medicine, Hirosaki University Graduate School of Medicine, Hirosaki 036-8562.
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Yoshida
authors.forename: Tomoyuki
authors.initials: T
authors.lastname: Kudo
authors.forename: Masahiro
authors.initials: M
authors.lastname: Sawada
authors.forename: Junichi
authors.initials: J
authors.lastname: Saito
authors.forename: Mitsuru
authors.initials: M
authors.lastname: Tonosaki
authors.forename: Kazuyoshi
authors.initials: K
authors.lastname: Hirota
mesh_terms: D000759:Adjuvants, Anesthesia / Q000009:adverse effects*; D000368:Aged; D000771:Anesthesia, Intravenous / Q000009:adverse effects*; D004938:Esophageal Neoplasms / Q000601:surgery; D016629:Esophagectomy; D005260:Female; D005283:Fentanyl / Q000009:adverse effects*; D006801:Humans; D007668:Kidney / Q000187:drug effects* / Q000503:physiopathology*; D007677:Kidney Function Tests; D008099:Liver / Q000187:drug effects* / Q000503:physiopathology*; D008111:Liver Function Tests; D008297:Male; D008875:Middle Aged; D010880:Piperidines / Q000009:adverse effects*; D011184:Postoperative Period; D000077208:Remifentanil
chemical_list: D000759:Adjuvants, Anesthesia; D010880:Piperidines; D000077208:Remifentanil; D005283:Fentanyl