title: Reduced incidence of lower-extremity amputations in people with diabetes in Scotland: a nationwide study.
abstract: OBJECTIVE
  To establish the incidence of nontraumatic lower-extremity amputation (LEA) in people with diabetes in Scotland.
  
  
  METHODS
  This cohort study linked national morbidity records and diabetes datasets to establish the number of people with diabetes who underwent nontraumatic major and minor LEA in Scotland from 2004 to 2008.
  
  
  RESULTS
  Two thousand three hundred eighty-two individuals with diabetes underwent a nontraumatic LEA between 2004 and 2008; 57.1% (n = 1,359) underwent major LEAs. The incidence of any LEA among persons with diabetes fell over the 5-year study period by 29.8% (3.04 per 1,000 in 2004 to 2.13 per 1,000 in 2008, P < 0.001). Major LEA rates decreased by 40.7% from 1.87 per 1,000 in 2004 to 1.11 per 1,000 in 2008 (P < 0.001).
  
  
  CONCLUSIONS
  There has been a significant reduction in the incidence of LEA in persons with diabetes in Scotland between 2004 and 2008, principally explained by a reduction in major amputation.
authors.affiliation: Diabetes & Endocrinology Department, Southern General Hospital, Glasgow, UK. brian.kennon@ggc.scot.nhs.uk
authors.forename: Brian
authors.initials: B
authors.lastname: Kennon
authors.forename: Graham P
authors.initials: GP
authors.lastname: Leese
authors.forename: Lynda
authors.initials: L
authors.lastname: Cochrane
authors.forename: Helen
authors.initials: H
authors.lastname: Colhoun
authors.forename: Sarah
authors.initials: S
authors.lastname: Wild
authors.forename: Duncan
authors.initials: D
authors.lastname: Stang
authors.forename: Naveed
authors.initials: N
authors.lastname: Sattar
authors.forename: Donald
authors.initials: D
authors.lastname: Pearson
authors.forename: Robert S
authors.initials: RS
authors.lastname: Lindsay
authors.forename: Andrew D
authors.initials: AD
authors.lastname: Morris
authors.forename: Shona
authors.initials: S
authors.lastname: Livingstone
authors.forename: Matthew
authors.initials: M
authors.lastname: Young
authors.forename: John
authors.initials: J
authors.lastname: McKnight
authors.forename: Scott
authors.initials: S
authors.lastname: Cunningham
mesh_terms: D000368:Aged; D000671:Amputation, Surgical / Q000706:statistics & numerical data*; D015331:Cohort Studies; D017719:Diabetic Foot / Q000150:complications* / Q000453:epidemiology / Q000601:surgery*; D005260:Female; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D012606:Scotland / Q000453:epidemiology