title: Crystal structure of the Campylobacter jejuni Cj0090 protein reveals a novel variant of the immunoglobulin fold among bacterial lipoproteins.
abstract: Bacterial lipoproteins play an important role in bacterial pathogenesis and physiology. The genome of Campylobacter jejuni, a major foodborn pathogen, is predicted to contain over 20 lipoproteins. However, the functions of the majority of C. jejuni lipoproteins remain unknown. The Cj0090 protein is encoded by a lipoprotein operon composed of cj0089, cj0090, and cj0091. Here, we report the crystal structure of Cj0090 at 1.9 Å resolution, revealing a novel variant of the immunoglobulin fold with β-sandwich architecture. The structure suggests that Cj0090 may be involved in protein-protein interactions, consistent with a possible role for bacterial lipoproteins.
authors.affiliation: Department of Biology and Biochemistry, University of Houston, TX 77204, USA.
authors.forename: Seonghee
authors.initials: S
authors.lastname: Paek
authors.forename: Fumihiro
authors.initials: F
authors.lastname: Kawai
authors.forename: Kyoung-Jae
authors.initials: KJ
authors.lastname: Choi
authors.forename: Hye-Jeong
authors.initials: HJ
authors.lastname: Yeo
mesh_terms: D000595:Amino Acid Sequence; D001426:Bacterial Proteins / Q000737:chemistry* / Q000235:genetics; D016123:Campylobacter jejuni / Q000737:chemistry* / Q000235:genetics; D018360:Crystallography, X-Ray; D007136:Immunoglobulins / Q000737:chemistry* / Q000235:genetics; D008074:Lipoproteins / Q000737:chemistry* / Q000235:genetics; D008958:Models, Molecular; D008969:Molecular Sequence Data; D015394:Molecular Structure; D017434:Protein Structure, Tertiary; D011994:Recombinant Proteins / Q000737:chemistry / Q000235:genetics; D016415:Sequence Alignment
chemical_list: D001426:Bacterial Proteins; D007136:Immunoglobulins; D008074:Lipoproteins; D011994:Recombinant Proteins