title: Evaluation of ricinine, a ricin biomarker, from a non-lethal castor bean ingestion.
abstract: A case is presented of the attempted suicide of a 58-year-old man using castor beans. The patient came to the emergency room complaining of nausea, vomiting and diarrhea for nine hours following the ingestion of six castor beans. Urine samples were taken throughout the hospital stay and submitted to the Centers for Disease Control and Prevention for analysis of ricinine, a castor bean component. The samples were found to be positive for ricinine, with a maximum concentration of 674 µg/g-creatinine excreted approximately 23 h post-exposure. Subsequent samples demonstrated lower ricinine concentrations, with the final sample taken at 62 h post-exposure at a concentration of 135 µg/g-creatinine of ricinine. The estimated urinary excretion half-life was approximately 15 h and the recovery of ricinine in the urine over the three days was estimated to be less than 10%. The patient fully recovered with supportive care and was discharged from the hospital six days after admission.
authors.affiliation: Division of Laboratory Science, Centers for Disease Control and Prevention, 4770 Buford Highway, Mailstop F44, Atlanta, Georgia 30341, USA.
authors.forename: Elizabeth I
authors.initials: EI
authors.lastname: Hamelin
authors.forename: Rudolph C
authors.initials: RC
authors.lastname: Johnson
authors.forename: John D
authors.initials: JD
authors.lastname: Osterloh
authors.forename: David J
authors.initials: DJ
authors.lastname: Howard
authors.forename: Jerry D
authors.initials: JD
authors.lastname: Thomas
mesh_terms: D000470:Alkaloids / Q000652:urine*; D015415:Biomarkers / Q000652:urine*; D002367:Ricinus communis / Q000737:chemistry*; D003967:Diarrhea / Q000139:chemically induced; D006207:Half-Life; D006801:Humans; D008297:Male; D008875:Middle Aged; D011728:Pyridones / Q000652:urine*; D012276:Ricin / Q000652:urine*; D013406:Suicide, Attempted; D016896:Treatment Outcome; D014839:Vomiting / Q000139:chemically induced
chemical_list: D000470:Alkaloids; D015415:Biomarkers; D011728:Pyridones; C019550:ricinine; D012276:Ricin