title: [Therapeutic effect of zoledronic acid on primary osteoporosis in elderly patients].
abstract: OBJECTIVE
  To observe the effect of zoledronic acid on bone mineral density (BMD) and bone metabolic markers in elderly patients with primary osteoporosis.
  
  
  METHODS
  Forty-eight elderly patients with osteoporosis were randomly assigned to zoledronic acid group (n=23) to receive treatment with 5 mg zoledronic acid once a year and the control group (n=25). In both groups, the patients were given Vitamin D3 and caltrate on a daily basis for a year. The bone mineral density (BMD) and bone metabolic markers were observed after the treatment.
  
  
  RESULTS
  Compared with the control group, zoledronic acid group had significantly higher L1-4, neck, Inter and Ward's BMD (P<0.05) with reduced B-NTX (P<0.05). The N-MID and CT showed no significant differences between the two groups (P<0.05).
  
  
  CONCLUSIONS
  Zoledronic acid administration once a year can increase BMD and lower the serum bone turnover metabolism, and can be used in the treatment of primary osteoporosis in elderly patients.
authors.affiliation: Department of Endocrinology, Instittue of Gerontology, Guangdong General Hospital, Guangzhou 510080, China. xuling0115@126.com
authors.forename: Ling
authors.initials: L
authors.lastname: Xu
authors.forename: Haiou
authors.initials: H
authors.lastname: Deng
authors.forename: Ximei
authors.initials: X
authors.lastname: Zhi
authors.forename: Weijie
authors.initials: W
authors.lastname: Zhang
authors.forename: Xiaona
authors.initials: X
authors.lastname: Wang
authors.forename: Wen
authors.initials: W
authors.lastname: Wu
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D015519:Bone Density; D050071:Bone Density Conservation Agents / Q000627:therapeutic use*; D004164:Diphosphonates / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D007093:Imidazoles / Q000627:therapeutic use*; D008297:Male; D010024:Osteoporosis / Q000188:drug therapy* / Q000378:metabolism; D016896:Treatment Outcome; D000077211:Zoledronic Acid
chemical_list: D050071:Bone Density Conservation Agents; D004164:Diphosphonates; D007093:Imidazoles; D000077211:Zoledronic Acid