title: Assessing transmission blockade in Plasmodium spp.
abstract: Here we describe a series of methods that can be used to assess the activities of "vaccines," drugs, and genetically modified vectors, for their abilities to inhibit transmission of Plasmodium from its vertebrate to its mosquito hosts. The selection of method to be used is determined by the purpose of the experiment, which can include the determination of the site/time of activity, and/or the potential reduction in transmission achieved.
authors.affiliation: The Malaria Centre, Department of Life Sciences, Imperial College, London, UK.
authors.forename: Andrew M
authors.initials: AM
authors.lastname: Blagborough
authors.forename: Michael J
authors.initials: MJ
authors.lastname: Delves
authors.forename: Chandra
authors.initials: C
authors.lastname: Ramakrishnan
authors.forename: Kalpana
authors.initials: K
authors.lastname: Lal
authors.forename: Geoffrey
authors.initials: G
authors.lastname: Butcher
authors.forename: Robert E
authors.initials: RE
authors.lastname: Sinden
mesh_terms: D000818:Animals; D000852:Anopheles / Q000469:parasitology; D000962:Antimalarials / Q000008:administration & dosage; D006801:Humans; D008288:Malaria / Q000517:prevention & control* / Q000635:transmission*; D017780:Malaria Vaccines / Q000008:administration & dosage / Q000276:immunology; D051379:Mice; D010962:Plasmodium berghei / Q000187:drug effects / Q000254:growth & development* / Q000276:immunology; D051381:Rats
chemical_list: D000962:Antimalarials; D017780:Malaria Vaccines