title: Reactive polymer as a versatile toolbox for construction of multifunctional superparamagnetic nanocomposites.
abstract: The development of magnetic nanoparticles with multiple functions has been an ever-growing field because of their diverse applications in drug delivery, biosensing, cell labeling, and so on. In this study, a facile method was developed to construct multifunctional magnetic nanocomposites. The approach is based on the use of poly(glycidyl methacrylate), PGMA, with numerous epoxy groups as reactive polymer to combine with fluorescent dye, the surface of magnetic nanoparticles, and targeting ligands directly without expatiatory functionality design. The resultant nanocomposites with good superparamagnetic and fluorescent properties could be exploited for bioimaging. Moreover, after conjugation with a model protein, namely, transferrin, which specifically targets cells overexpressing transferrin receptors, the nanocomposites could be used selectively to recognize Hela cells in comparison with nonconjugated ones. These results indicate that the newly designed magnetic nanocomposites with PGMA as functional polymer could serve as a novel versatile platform to conjugate with various molecules for construction of diverse multifunctional magnetic nanocomposites to meet different requirements and potential uses in nanomedicine and biological chemistry.
authors.affiliation: Beijing National Laboratory of Molecular Sciences, Institute of Chemistry, Chinese Academy of Sciences, Beiyijie, PR China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Shen
authors.forename: Lingzhi
authors.initials: L
authors.lastname: Zhao
authors.forename: Li
authors.initials: L
authors.lastname: Qi
authors.forename: Juan
authors.initials: J
authors.lastname: Qiao
authors.forename: Lanqun
authors.initials: L
authors.lastname: Mao
authors.forename: Yi
authors.initials: Y
authors.lastname: Chen
mesh_terms: D002470:Cell Survival / Q000187:drug effects; D052203:Ferrosoferric Oxide / Q000737:chemistry; D005456:Fluorescent Dyes / Q000737:chemistry; D006367:HeLa Cells; D006801:Humans; D008280:Magnetics; D058185:Magnetite Nanoparticles / Q000737:chemistry* / Q000633:toxicity; D008856:Microscopy, Fluorescence; D011108:Polymers / Q000737:chemistry*; D011109:Polymethacrylic Acids / Q000737:chemistry; D061250:Transferrins / Q000737:chemistry / Q000378:metabolism
chemical_list: D005456:Fluorescent Dyes; D058185:Magnetite Nanoparticles; D011108:Polymers; D011109:Polymethacrylic Acids; D061250:Transferrins; C042535:polyglycidyl methacrylate; D052203:Ferrosoferric Oxide