title: The α2-adrenoceptor antagonist yohimbine normalizes increased islet blood flow in GK rats: a model of type 2 diabetes.
abstract: Overexpression of α2A-adrenoceptors contributes to type 2 diabetes in GK rats. We aimed to investigate if α2-adrenoceptor inhibition affected islet blood flow in these rats. Anesthetized GK and Wistar-F rats were given the α2-adrenoceptor inhibitor yohimbine (2.5 mg/kg BW) intravenously. The GK rats had higher blood glucose and serum insulin concentrations than WF rats. Yohimbine affected neither of these values in WF rats, but decreased blood glucose and increased serum insulin concentrations in GK rats. Total pancreatic and islet blood flows, measured with microspheres, were increased in GK when compared to WF rats. Yohimbine affected none of the blood flow values in WF rats, whereas islet blood flow in GK rats was reduced to values similar to those seen in WF rats. Overexpression of α2-adrenoceptors may contribute to the increased islet blood flow seen in GK rats, and may be eligible for pharmacologic intervention.
authors.affiliation: Department of Medical cell Biology, Uppsala University, Uppsala, Sweden. Monica.Sandberg@mcb.uu.se
authors.forename: M
authors.initials: M
authors.lastname: Sandberg
authors.forename: U
authors.initials: U
authors.lastname: Pettersson
authors.forename: J
authors.initials: J
authors.lastname: Henriksnäs
authors.forename: L
authors.initials: L
authors.lastname: Jansson
mesh_terms: D058669:Adrenergic alpha-2 Receptor Antagonists / Q000494:pharmacology*; D000758:Anesthesia; D000818:Animals; D003924:Diabetes Mellitus, Type 2 / Q000097:blood*; D004195:Disease Models, Animal; D007275:Injections, Intravenous; D007515:Islets of Langerhans / Q000098:blood supply* / Q000187:drug effects*; D008297:Male; D010179:Pancreas / Q000098:blood supply / Q000187:drug effects; D051381:Rats; D011920:Rats, Inbred WF; D012039:Regional Blood Flow / Q000187:drug effects; D015016:Yohimbine / Q000008:administration & dosage / Q000494:pharmacology*
chemical_list: D058669:Adrenergic alpha-2 Receptor Antagonists; D015016:Yohimbine