title: Synthesis and characterization of Sant-75 derivatives as Hedgehog-pathway inhibitors.
abstract: Sant-75 is a newly identified potent inhibitor of the hedgehog pathway. We designed a diversity-oriented synthesis program, and synthesized a series of Sant-75 analogues, which lays the foundation for further investigation of the structure-activity relationship of this important class of hedgehog-pathway inhibitors.
authors.affiliation: Laboratory of Chemical Genomics, School of Chemical Biology and Biotechnology, Peking University Shenzhen Graduate School, Shenzhen 518055, China ; Shenzhen Shengjie Biotech Co., Ltd., Shenzhen 518055, China.
authors.forename: Chao
authors.initials: C
authors.lastname: Che
authors.forename: Song
authors.initials: S
authors.lastname: Li
authors.forename: Bo
authors.initials: B
authors.lastname: Yang
authors.forename: Shengchang
authors.initials: S
authors.lastname: Xin
authors.forename: Zhixiong
authors.initials: Z
authors.lastname: Yu
authors.forename: Taofeng
authors.initials: T
authors.lastname: Shao
authors.forename: Chuanye
authors.initials: C
authors.lastname: Tao
authors.forename: Shuo
authors.initials: S
authors.lastname: Lin
authors.forename: Zhen
authors.initials: Z
authors.lastname: Yang