title: Deciphering the function of leucine-rich repeat kinase 2 and targeting its dysfunction in disease.
abstract: LRRK2 (leucine-rich repeat kinase 2) is a gene of unknown function that has been linked to a number a human diseases, including PD (Parkinson's disease), IBD (inflammatory bowel disease), leprosy and cancer. The papers from the LRRK2: Function and Dysfunction meeting in this issue of Biochemical Society Transactions explore our growing knowledge of LRRK2's normal function, the role that it plays in disease and emerging strategies to exploit LRRK2 as a therapeutic target.
authors.affiliation: Department of Molecular Neuroscience, UCL Institute of Neurology, Queen Square, London WC1N 3BG, U.K. patrick.lewis@ucl.ac.uk
authors.forename: Patrick A
authors.initials: PA
authors.lastname: Lewis
authors.forename: Dario R
authors.initials: DR
authors.lastname: Alessi
mesh_terms: D006801:Humans; D015212:Inflammatory Bowel Diseases / Q000201:enzymology* / Q000378:metabolism; D007918:Leprosy / Q000201:enzymology* / Q000378:metabolism; D000071158:Leucine-Rich Repeat Serine-Threonine Protein Kinase-2; D009369:Neoplasms / Q000201:enzymology* / Q000378:metabolism; D010300:Parkinson Disease / Q000201:enzymology* / Q000378:metabolism; D017346:Protein Serine-Threonine Kinases / Q000378:metabolism*
chemical_list: C495280:LRRK2 protein, human; D000071158:Leucine-Rich Repeat Serine-Threonine Protein Kinase-2; D017346:Protein Serine-Threonine Kinases