title: Distal renal tubular acidosis that became exacerbated by proton pump inhibitor use.
abstract: Acid-base imbalances and electrolyte disorders induced by proton pump inhibitors (PPIs) are extremely rare. However, under certain conditions, PPIs may cause metabolic acidosis or hypokalemia, probably due to an inhibitory action on the proton pump that contributes to H(+) and K(+) homeostasis in the kidney. We herein present a case of marked hypokalemia accompanied by distal renal tubular acidosis in which a PPI appeared to contribute to the pathophysiology of metabolic acidosis.
authors.affiliation: Department of Diabetes Mellitus and Endocrinology, Osaka Red Cross Hospital, Japan.
authors.forename: Natsumi
authors.initials: N
authors.lastname: Okamoto
authors.forename: Takuo
authors.initials: T
authors.lastname: Nambu
authors.forename: Yuki
authors.initials: Y
authors.lastname: Matsuda
authors.forename: Koji
authors.initials: K
authors.lastname: Matsuo
authors.forename: Keisuke
authors.initials: K
authors.lastname: Osaki
authors.forename: Yugo
authors.initials: Y
authors.lastname: Kanai
authors.forename: Yoshihisa
authors.initials: Y
authors.lastname: Ogawa
authors.forename: Shin
authors.initials: S
authors.lastname: Yonemitsu
authors.forename: Ryuichi
authors.initials: R
authors.lastname: Kita
authors.forename: Seiji
authors.initials: S
authors.lastname: Muro
authors.forename: Akira
authors.initials: A
authors.lastname: Sugawara
authors.forename: Shogo
authors.initials: S
authors.lastname: Oki
mesh_terms: D000141:Acidosis, Renal Tubular / Q000139:chemically induced* / Q000175:diagnosis; D005260:Female; D005764:Gastroesophageal Reflux / Q000188:drug therapy*; D017506:H(+)-K(+)-Exchanging ATPase / Q000187:drug effects; D006706:Homeostasis / Q000187:drug effects; D006801:Humans; D006859:Hydrogen / Q000378:metabolism; D007008:Hypokalemia / Q000139:chemically induced / Q000175:diagnosis; D007668:Kidney / Q000378:metabolism; D008875:Middle Aged; D011188:Potassium / Q000378:metabolism; D054328:Proton Pump Inhibitors / Q000009:adverse effects* / Q000494:pharmacology / Q000627:therapeutic use*
chemical_list: D054328:Proton Pump Inhibitors; D006859:Hydrogen; D017506:H(+)-K(+)-Exchanging ATPase; D011188:Potassium