title: Therapeutic gene products delivery by neuron stem cells.
abstract: Malignant tumors remain virtually untreatable and inevitably lethal despite extensive surgical excision and adjuvant radio- and chemotherapy. Therefore, the development of more effective tumor-selective therapies is necessary. Stem/progenitor cells that self-renew, differentiate and display inherent tumor-tropic properties can be exploited for targeted delivery of therapeutic genes to invasive and metastatic tumors. In this review, we mainly introduce the application in Glioma, Breast cancer, Spinal cord injury, AD and so on. The promising field of stem cell research as it applies to regenerative medicine is still in infancy, but its potential appears limitless, and we are blessed to be involved in this exciting realm of research.
authors.affiliation: Department of Stem Cell Center, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.
authors.forename: Jie
authors.initials: J
authors.lastname: Tan
authors.forename: Yanna
authors.initials: Y
authors.lastname: Meng
authors.forename: Shiang
authors.initials: S
authors.lastname: Huang
authors.forename: Ping
authors.initials: P
authors.lastname: Wang
mesh_terms: D000544:Alzheimer Disease / Q000628:therapy; D000818:Animals; D001932:Brain Neoplasms / Q000628:therapy; D001943:Breast Neoplasms / Q000628:therapy; D005260:Female; D018014:Gene Transfer Techniques; D015316:Genetic Therapy / Q000379:methods; D005910:Glioma / Q000628:therapy; D006801:Humans; D058953:Neural Stem Cells; D013119:Spinal Cord Injuries / Q000628:therapy