title: Synthesis, characterization and cytotoxicity of a carboxylic ligand 2,2-bis(3-phenylpropyl) malonic acid and a corresponding Mn(II) complex.
abstract: The organic ligand Hbpmc and the polymeric complex [Mn(bpmc)(2)(4,4'-bipy)(H(2)O)(2)](n)·3H(2)O (4,4'-bipy = 4,4'-bipyridine, Hbpmc = 2,2-bis(3-phenylpropyl) malonic acid), which have both a lipophilic group (aromatic ring) and a hydrophilic group (non-coordination carboxyl), were synthesized and characterized by IR spectra, elemental analysis and X-ray single-crystal diffraction. The interaction of the complexes with HC-DNA was investigated by fluorescence spectroscopy. Gel electrophoresis assay demonstrates the ability to cleave the extracted HC-DNA. The value of IC(50) is to understand the effect of cytotoxic activity which is lower than cisplatin and higher than the ligand Hbpmc. The apoptotic tests show that the complexes apparently have an apoptotic effect on Hela cells.
authors.affiliation: Department of Coordination Chemistry, International Key Laboratory of Shenyang Inorganic Molecule-Based Chemistry, Shenyang University of Chemical Technology, Shenyang 110142, China.
authors.forename: Ming-chang
authors.initials: MC
authors.lastname: Zhu
authors.forename: Lei
authors.initials: L
authors.lastname: Dai
authors.forename: En-jun
authors.initials: EJ
authors.lastname: Gao
authors.forename: Lin
authors.initials: L
authors.lastname: Lin
authors.forename: Bo
authors.initials: B
authors.lastname: Wang
authors.forename: Lei
authors.initials: L
authors.lastname: Liu
mesh_terms: D017209:Apoptosis / Q000187:drug effects; D002264:Carboxylic Acids / Q000737:chemistry*; D045744:Cell Line, Tumor; D056831:Coordination Complexes / Q000138:chemical synthesis* / Q000378:metabolism / Q000633:toxicity; D018360:Crystallography, X-Ray; D004247:DNA / Q000737:chemistry / Q000378:metabolism; D006367:HeLa Cells; D006801:Humans; D007477:Ions / Q000737:chemistry; D008024:Ligands; D008314:Malonates / Q000737:chemistry*; D008345:Manganese / Q000737:chemistry*; D008968:Molecular Conformation; D011725:Pyridines / Q000737:chemistry
chemical_list: C583940:2,2-bis(3-phenylpropyl)malonic acid; D002264:Carboxylic Acids; D056831:Coordination Complexes; D007477:Ions; D008024:Ligands; D008314:Malonates; D011725:Pyridines; D008345:Manganese; D004247:DNA; C030290:malonic acid; C034306:4,4'-bipyridyl