title: Retention of antimicrobial activity after reconstitution of doxycycline gel.
abstract: Doxycycline gel is licensed for the treatment of periodontal disease in dogs. Package labeling indicates the product is stable after reconstitution of antibiotic with polymer gel for up to 3-days when stored at room temperature. The purpose of this study was to determine if reconstituted doxycycline gel retained antimicrobial activity for greater than 3-days. The antibiotic activity of reconstituted doxycycline gel was evaluated against antimicrobial testing strains of bacteria and bacteria collected from throat swabs of 2 dogs using a standard disc diffusion assay. Our results showed that reconstituted doxycycline gel retained undiminished antimicrobial activity for a minimum of 8-weeks.
authors.affiliation: Department of Biological and Physical Sciences, Montana State University, Billings, Montana 59101, USA. mdennis@msubillings.edu
authors.forename: Michael
authors.initials: M
authors.lastname: Dennis
authors.forename: Teresa
authors.initials: T
authors.lastname: Wilson
authors.forename: Tony
authors.initials: T
authors.lastname: Woodward
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000737:chemistry* / Q000494:pharmacology*; D004285:Dogs; D004318:Doxycycline / Q000008:administration & dosage / Q000737:chemistry* / Q000494:pharmacology*; D024881:Drug Resistance, Bacterial; D013293:Enterococcus faecalis / Q000187:drug effects; D004926:Escherichia coli / Q000187:drug effects; D005782:Gels; D013211:Staphylococcus aureus / Q000187:drug effects
chemical_list: D000900:Anti-Bacterial Agents; D005782:Gels; D004318:Doxycycline