title: Differences in the risk factors of reflux esophagitis according to age in Korea.
abstract: The prevalence of gastroesophageal reflux disease in Korea has been believed to be low, but the incidence of gastroesophageal reflux disease in Korea is expected to increase because of the longer life expectancy and more ingestion of westernized food. The aim of this study was to report differences in the risk factors of reflux esophagitis (RE) according to age in Korea. We prospectively recruited the subjects who had RE among those who visited a health promotion center for upper gastrointestinal cancer surveillance at Hallym Medical Center (five institutions) between January 2008 and February 2009. The enrolled study participants comprised 742 subjects with RE and 1484 healthy controls. The independent risk factors of RE in young and adult group were male sex, smoking, coffee, body mass index ≥ 25, hiatal hernia, and Helicobacter pylori negativity. The risk factors of RE in elderly group were smoking, coffee, and hiatal hernia. The risk factors for RE according to age group were found to differ. In elderly group, Helicobacter pylori infection was not a significant protective factor contrary to young and adult groups.
authors.affiliation: Department of Gastroenterology, Hallym University Sacred Heart Hospital, Hallym University College of Medicine, Seoul, Korea.
authors.forename: C H
authors.initials: CH
authors.lastname: Park
authors.forename: K O
authors.initials: KO
authors.lastname: Kim
authors.forename: I H
authors.initials: IH
authors.lastname: Baek
authors.forename: M H
authors.initials: MH
authors.lastname: Choi
authors.forename: H J
authors.initials: HJ
authors.lastname: Jang
authors.forename: S H
authors.initials: SH
authors.lastname: Kae
authors.forename: J B
authors.initials: JB
authors.lastname: Kim
authors.forename: G H
authors.initials: GH
authors.lastname: Baik
authors.forename: W G
authors.initials: WG
authors.lastname: Shin
authors.forename: K H
authors.initials: KH
authors.lastname: Kim
authors.forename: H Y
authors.initials: HY
authors.lastname: Kim
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D016022:Case-Control Studies; D003069:Coffee; D015331:Cohort Studies; D004327:Drinking Behavior; D004942:Esophagitis, Peptic / Q000175:diagnosis / Q000453:epidemiology*; D005260:Female; D016481:Helicobacter Infections / Q000453:epidemiology*; D016480:Helicobacter pylori; D006551:Hernia, Hiatal / Q000453:epidemiology*; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D050177:Overweight / Q000453:epidemiology*; D011446:Prospective Studies; D056910:Republic of Korea / Q000453:epidemiology; D012307:Risk Factors; D012737:Sex Factors; D012907:Smoking / Q000453:epidemiology*; D055815:Young Adult
chemical_list: D003069:Coffee