title: Retention of bone strength by feeding of milk and dairy products in ovariectomized rats: involvement of changes in serum levels of 1alpha, 25(OH)2D3 and FGF23.
abstract: The current study compared the effects of milk, yogurt or whey on the bone strength, body composition and serum biomarkers. Forty 12-week-old female Sprague-Dawley rats were ovariectomized (OVX), and another nine rats received a sham operation (Sham-Cont). After a 1-week recovery period, the OVX rats were divided into four dietary groups: OVX-control group (OVX-Cont), 17% skimmed milk powder diet group (OVX-Milk), 17% powdered fermented milk diet group (OVX-Yogurt) and 12% whey powder and 6% whey protein extract diet group (OVX-Whey) (n=10 in each group). The protein, nitrogen, fat, calcium and phosphorus contents of the experimental diets were adjusted to be similar to the control diet (AIN-93M). Eighty-four days after the beginning of the experimental diet, the total bone mineral density and bone mineral contents of lumbar vertebrae were significantly higher in the OVX-Milk and OVX-Whey groups than in the OVX-Cont group. Furthermore, the level of 1alpha, 25-dihydroxyvitamin D3 [1alpha, 25(OH)2D3] was significantly lower, while the serum level of FGF23 was significantly higher in the OVX-Milk, OVX-Yogurt and OVX-Whey groups than in the OVX-Cont group. These findings suggest that milk and the dairy products could improve bone metabolism in a postmenopausal animal model at least partly through changing the balance between 1alpha, 25(OH)2D3 and FGF23.
authors.affiliation: Department of Food and Nutrition, Faculty of Human Sciences and Design, Japan Women's University, Tokyo 112-8681, Japan.
authors.forename: Rieko
authors.initials: R
authors.lastname: Tanabe
authors.forename: Mayu
authors.initials: M
authors.lastname: Haraikawa
authors.forename: Natsuko
authors.initials: N
authors.lastname: Sogabe
authors.forename: Aoi
authors.initials: A
authors.lastname: Sugimoto
authors.forename: Yuka
authors.initials: Y
authors.lastname: Kawamura
authors.forename: Satoshi
authors.initials: S
authors.lastname: Takasugi
authors.forename: Masashi
authors.initials: M
authors.lastname: Nagata
authors.forename: Ayako
authors.initials: A
authors.lastname: Nakane
authors.forename: Akira
authors.initials: A
authors.lastname: Yamaguchi
authors.forename: Tadahiro
authors.initials: T
authors.lastname: Iimura
authors.forename: Masae
authors.initials: M
authors.lastname: Goseki-Sone
mesh_terms: D000818:Animals; D001835:Body Weight; D015519:Bone Density / Q000502:physiology; D001842:Bone and Bones / Q000378:metabolism*; D002117:Calcitriol / Q000097:blood*; D002136:Calcium, Dietary / Q000378:metabolism; D004872:Ergocalciferols / Q000097:blood*; D005260:Female; D000089703:Fibroblast Growth Factor-23; D005346:Fibroblast Growth Factors / Q000097:blood*; D006801:Humans; D008892:Milk; D008894:Milk Proteins / Q000008:administration & dosage; D010052:Ovariectomy; D051381:Rats; D017207:Rats, Sprague-Dawley; D000067816:Whey Proteins; D015014:Yogurt
chemical_list: D002136:Calcium, Dietary; D004872:Ergocalciferols; C000717427:FGF23 protein, human; C505605:Fgf23 protein, rat; D008894:Milk Proteins; D000067816:Whey Proteins; D005346:Fibroblast Growth Factors; D000089703:Fibroblast Growth Factor-23; D002117:Calcitriol