title: Association between polymorphisms of the DBH and DAT1 genes and attention deficit hyperactivity disorder in children from Jordan.
abstract: Attention deficit hyperactivity disorder (ADHD) is one of the most common neuropsychiatric disorders in children. In this study, the association between 10-repeats in the DAT1 gene and the (GT)n repeat in the DBH gene and ADHD was examined in children from Jordan. In addition, the levels of dopamine-β-hydroxylase enzyme activity in the plasma of ADHD children were evaluated. Fifty children with ADHD and 50 age- and gender-matched control subjects were recruited. The results showed significant differences between the ADHD group and controls with respect to the plasma levels of dopamine-β-hydroxylase enzyme activity (25.4±2.3 vs. 84.7±5.0 μmol/min; p<0.01). Moreover, the 10-repeat DAT1 gene and (GT)n DBH gene polymorphisms were significantly associated with ADHD development (p<0.05). In conclusion, the DBH and DAT1 genes appear to play a role in the development of ADHD in the Jordanian population.
authors.affiliation: Departments of Medical Laboratory Sciences, and.
authors.forename: Mohammad Y
authors.initials: MY
authors.lastname: Gharaibeh
authors.forename: Sajida
authors.initials: S
authors.lastname: Batayneh
authors.forename: Omar F
authors.initials: OF
authors.lastname: Khabour
authors.forename: Azhar
authors.initials: A
authors.lastname: Daoud