title: Synthesis, characterization and anti-diabetic therapeutic potential of a new benzyl acid-derivatized kojic acid vanadyl complex.
abstract: Vanadium complexes are potent hypoglycemic agents and of great potential for therapeutical treatment of diabetes. In the present work, a novel vanadium compound, bis ((5-hydroxy-4-oxo-4H-pyran-2-yl)methyl benzoatato) oxovanadium (IV) (BBOV) has been synthesized. Treatment of STZ-induced diabetic rats with BBOV restored the blood glucose to normal level and ameliorated glucose tolerance. The hypoglycemic effect of BBOV is similar to that of bis (maltolato) oxovanadium but is less toxic in median lethal dose. Overall, the present work will provide useful information for further development of new anti-diabetic vanadium compounds.
authors.affiliation: School of Pharmaceutical Sciences, Guangxi Medical University, 22 Shuangyong Road, Nanning, 530021, Guangxi, People's Republic of China.
authors.forename: Yong-Biao
authors.initials: YB
authors.lastname: Wei
authors.forename: Xiao-Da
authors.initials: XD
authors.lastname: Yang
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000008:administration & dosage / Q000138:chemical synthesis / Q000494:pharmacology; D001565:Benzoates / Q000737:chemistry*; D001786:Blood Glucose / Q000187:drug effects; D003921:Diabetes Mellitus, Experimental / Q000188:drug therapy*; D007004:Hypoglycemic Agents / Q000008:administration & dosage / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D015394:Molecular Structure; D009942:Organometallic Compounds / Q000008:administration & dosage / Q000138:chemical synthesis / Q000494:pharmacology*; D011753:Pyrones / Q000737:chemistry*; D051381:Rats; D017207:Rats, Sprague-Dawley; D014639:Vanadium / Q000737:chemistry*
chemical_list: D000975:Antioxidants; D001565:Benzoates; D001786:Blood Glucose; D007004:Hypoglycemic Agents; D009942:Organometallic Compounds; D011753:Pyrones; D014639:Vanadium; C011890:kojic acid