title: Endoplasmic reticulum-mitochondria contacts: function of the junction.
abstract: The most well-characterized organelle contact sites are those between the endoplasmic reticulum (ER) and mitochondria. Increased understanding is being gained of how ER-mitochondria contact sites are organized and which factors converge at this interface, some of which may provide a tethering function. The role of the ER-mitochondria junction in coordinating the functions of these two organelles is also becoming clearer, and it has been shown to be involved in the regulation of lipid synthesis, Ca(2+) signalling and the control of mitochondrial biogenesis and intracellular trafficking.
authors.affiliation: Department of Molecular, Cellular, and Developmental Biology, University of Colorado, Boulder, 80309, USA.
authors.forename: Ashley A
authors.initials: AA
authors.lastname: Rowland
authors.forename: Gia K
authors.initials: GK
authors.lastname: Voeltz
mesh_terms: D000818:Animals; D020013:Calcium Signaling; D004721:Endoplasmic Reticulum / Q000378:metabolism* / Q000648:ultrastructure*; D008055:Lipids / Q000096:biosynthesis; D008928:Mitochondria / Q000378:metabolism* / Q000648:ultrastructure*; D051336:Mitochondrial Membranes / Q000378:metabolism / Q000648:ultrastructure; D063269:Mitochondrial Turnover; D021381:Protein Transport; D015398:Signal Transduction
chemical_list: D008055:Lipids