title: A meshfree method for simulating myocardial electrical activity.
abstract: An element-free Galerkin method (EFGM) is proposed to simulate the propagation of myocardial electrical activation without explicit mesh constraints using a monodomain model. In our framework the geometry of myocardium is first defined by a meshfree particle representation that is, a sufficient number of sample nodes without explicit connectivities are placed in and inside the surface of myocardium. Fiber orientations and other material properties of myocardium are then attached to sample nodes according to their geometrical locations, and over the meshfree particle representation spatial variation of these properties is approximated using the shape function of EFGM. After the monodomain equations are converted to their Galerkin weak form and solved using EFGM, the propagation of myocardial activation can be simulated over the meshfree particle representation. The derivation of this solution technique is presented along a series of numerical experiments and a solution of monodomain model using a FitzHugh-Nagumo (FHN) membrane model in a canine ventricular model and a human-heart model which is constructed from digitized virtual Chinese dataset.
authors.affiliation: Shenzhen Institutes of Advanced Technology, Chinese Academy of Science, Shenzhen 518055, China.
authors.forename: Heye
authors.initials: H
authors.lastname: Zhang
authors.forename: Huajun
authors.initials: H
authors.lastname: Ye
authors.forename: Wenhua
authors.initials: W
authors.lastname: Huang
mesh_terms: D000465:Algorithms; D000818:Animals; D019295:Computational Biology / Q000379:methods; D003198:Computer Simulation; D016208:Databases, Factual; D004058:Diffusion; D004285:Dogs; D004594:Electrophysiology / Q000379:methods; D020342:Finite Element Analysis; D006329:Heart Conduction System / Q000502:physiology; D006801:Humans; D008564:Membrane Potentials; D008953:Models, Anatomic; D008955:Models, Cardiovascular; D015233:Models, Statistical; D009200:Myocardial Contraction / Q000502:physiology; D009206:Myocardium / Q000473:pathology*