title: Enhanced fitness: a randomized controlled trial of the effects of home-based physical activity counseling on glycemic control in older adults with prediabetes mellitus.
abstract: OBJECTIVE
  To determine whether a home-based multicomponent physical activity counseling (PAC) intervention is effective in reducing glycemic measures in older outpatients with prediabetes mellitus.
  
  
  METHODS
  Controlled clinical trial.
  
  
  METHODS
  Primary care clinics of the Durham Veterans Affairs (VA) Medical Center between September 29, 2008, and March 25, 2010.
  
  
  METHODS
  Three hundred two overweight (body mass index 25-45 kg/m(2) ), older (60-89) outpatients with impaired glucose tolerance (fasting blood glucose 100-125 mg/dL, glycosylated hemoglobin (HbA1c) <7%) randomly assigned to a PAC intervention group (n = 180) or a usual care control group (n = 122).
  
  
  METHODS
  A 12-month, home-based multicomponent PAC program including one in-person baseline counseling session, regular telephone counseling, physician endorsement in clinic with monthly automated encouragement, and customized mailed materials. All study participants, including controls, received a consultation in a VA weight management program.
  
  
  METHODS
  The primary outcome was a homeostasis model assessment of insulin resistance (HOMA-IR), calculated from fasting insulin and glucose levels at baseline and 3 and 12 months. HbA1c was the secondary indicator of glycemic control. Other secondary outcomes were anthropometric measures and self-reported physical activity, health-related quality of life, and physical function.
  
  
  RESULTS
  There were no significant differences between the PAC and control groups over time for any of the glycemic indicators. Both groups had small declines over time of approximately 6% in fasting blood glucose (P < .001), and other glycemic indicators remained stable. The declines in glucose were not sufficient to affect the change in HOMA-IR scores due to fluctuations in insulin over time. Endurance physical activity increased significantly in the PAC group (P < .001) and not in the usual care group.
  
  
  CONCLUSIONS
  Home-based telephone counseling increased physical activity levels but was insufficient to improve glycemic indicators in older outpatients with prediabetes mellitus.
authors.affiliation: Geriatric Research, Education, and Clinical Center, Veterans Affairs Medical Center, Durham, North Carolina 27705, USA. miriam.morey@duke.edu
authors.forename: Miriam C
authors.initials: MC
authors.lastname: Morey
authors.forename: Carl F
authors.initials: CF
authors.lastname: Pieper
authors.forename: David E
authors.initials: DE
authors.lastname: Edelman
authors.forename: William S
authors.initials: WS
authors.lastname: Yancy
authors.forename: Jennifer B
authors.initials: JB
authors.lastname: Green
authors.forename: Helen
authors.initials: H
authors.lastname: Lum
authors.forename: Matthew J
authors.initials: MJ
authors.lastname: Peterson
authors.forename: Richard
authors.initials: R
authors.lastname: Sloane
authors.forename: Patricia A
authors.initials: PA
authors.lastname: Cowper
authors.forename: Hayden B
authors.initials: HB
authors.lastname: Bosworth
authors.forename: Kim M
authors.initials: KM
authors.lastname: Huffman
authors.forename: James T
authors.initials: JT
authors.lastname: Cavanaugh
authors.forename: Katherine S
authors.initials: KS
authors.lastname: Hall
authors.forename: Megan P
authors.initials: MP
authors.lastname: Pearson
authors.forename: Gregory A
authors.initials: GA
authors.lastname: Taylor
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000502:physiology; D000886:Anthropometry; D001786:Blood Glucose / Q000032:analysis*; D015992:Body Mass Index; D003376:Counseling; D005260:Female; D006442:Glycated Hemoglobin / Q000032:analysis; D006706:Homeostasis; D006801:Humans; D007333:Insulin Resistance; D008297:Male; D008875:Middle Aged; D009043:Motor Activity / Q000502:physiology*; D010809:Physical Fitness / Q000502:physiology*; D011236:Prediabetic State / Q000503:physiopathology* / Q000517:prevention & control*; D011788:Quality of Life; D013997:Time Factors; D016896:Treatment Outcome; D014728:Veterans
chemical_list: D001786:Blood Glucose; D006442:Glycated Hemoglobin