title: A case of metachronous double primary neuroendocrine cancer in pancreas/ileum and uterine cervix.
abstract: We describe an unusual case of a 50-year-old female patient developing two primary cancers with neuroendocrine features. Initially the patient underwent surgery for an entero-pancreatic neuroendocrine carcinoma. During the subsequent follow-up she experienced some episodes of vaginal bleeding with negative PET scanning with the tracer fluorine-18 (F-18) fluorodeoxyglucose (FDG). A Papanicolaou (pap) smear and an endometrial biopsy revealed a primary neuroendocrine cancer of the uterine cervix. The present case underlines the importance of clinical follow-up after a diagnosis of intestinal neuroendocrine tumor, investigating any new symptom. Female patients, after the diagnosis of entero-pancreatic neuroendocrine carcinoma, must be recommended to continue screening pap test examinations for the likelihood of classical squamous and glandular cervical cancers and also for neuroendocrine cervical cancer.
authors.affiliation: Department of Science for Woman and Child Health, University of Florence, Florence, Italy. giovanni83@email.it
authors.forename: Giovanni
authors.initials: G
authors.lastname: Sisti
authors.forename: Anna Maria
authors.initials: AM
authors.lastname: Buccoliero
authors.forename: Luca
authors.initials: L
authors.lastname: Novelli
authors.forename: Maddalena
authors.initials: M
authors.lastname: Sansovini
authors.forename: Stefano
authors.initials: S
authors.lastname: Severi
authors.forename: Annalisa
authors.initials: A
authors.lastname: Pieralli
authors.forename: Lorenzo
authors.initials: L
authors.lastname: Livi
authors.forename: Massimiliano
authors.initials: M
authors.lastname: Fambrini
mesh_terms: D005260:Female; D006801:Humans; D007082:Ileum / Q000473:pathology*; D007414:Intestinal Neoplasms / Q000000981:diagnostic imaging*; D008875:Middle Aged; D018358:Neuroendocrine Tumors / Q000000981:diagnostic imaging*; D010190:Pancreatic Neoplasms / Q000000981:diagnostic imaging*; D049268:Positron-Emission Tomography; D002583:Uterine Cervical Neoplasms / Q000000981:diagnostic imaging*