title: VEGF and CD105 immunoexpression in squamous cervical carcinomas and associated precancerous lesions.
abstract: In this study, we analyzed the VEGF and CD105 immunoexpression in 24 cervical squamous cell carcinomas and CIN associated lesions with different degrees. For both lesions, MVD values were higher in patients who had associated risk factors. VEGF and MVD expression increased in both categories for high-grade lesions, respectively CIN III lesions compared with CIN I/II and poorly differentiated carcinomas compared with well-differentiated ones. Also, there was a statistically significant association between VEGF and MVD in poorly differentiated carcinoma and CIN III. The study indicated that analyzed markers were specific for both early and advanced stages of cervical angiogenesis. Maximum values of VEGF and MVD in CIN III designate this lesion as critical to the progression of neoplasia.
authors.affiliation: Department of Pathology, University of Medicine and Pharmacy of Craiova, Craiova, Romania.
authors.forename: Desdemona
authors.initials: D
authors.lastname: Stepan
authors.forename: Cristiana
authors.initials: C
authors.lastname: Simionescu
authors.forename: A
authors.initials: A
authors.lastname: Stepan
authors.forename: Mihaela
authors.initials: M
authors.lastname: Muntean
authors.forename: B
authors.initials: B
authors.lastname: Voinea
mesh_terms: D000328:Adult; D015703:Antigens, CD / Q000096:biosynthesis*; D014408:Biomarkers, Tumor / Q000096:biosynthesis*; D002294:Carcinoma, Squamous Cell / Q000098:blood supply / Q000378:metabolism* / Q000473:pathology; D000071063:Endoglin; D005260:Female; D006801:Humans; D008875:Middle Aged; D009389:Neovascularization, Pathologic / Q000378:metabolism / Q000473:pathology; D011230:Precancerous Conditions / Q000098:blood supply / Q000378:metabolism; D011956:Receptors, Cell Surface / Q000096:biosynthesis*; D012189:Retrospective Studies; D012307:Risk Factors; D002583:Uterine Cervical Neoplasms / Q000098:blood supply / Q000378:metabolism* / Q000473:pathology; D042461:Vascular Endothelial Growth Factor A / Q000096:biosynthesis*; D002578:Uterine Cervical Dysplasia / Q000098:blood supply / Q000378:metabolism* / Q000473:pathology
chemical_list: D015703:Antigens, CD; D014408:Biomarkers, Tumor; C064206:ENG protein, human; D000071063:Endoglin; D011956:Receptors, Cell Surface; C467484:VEGFA protein, human; D042461:Vascular Endothelial Growth Factor A