title: The role of circadian clocks in metabolic disease.
abstract: The circadian clock is a highly conserved timing system, resonating physiological processes to 24-hour environmental cycles. Circadian misalignment is emerging as a risk factor of metabolic disease. The molecular clock resides in all metabolic tissues, the dysfunction of which is associated with perturbed energy metabolism. In this article, we will review current knowledge about molecular mechanisms of the circadian clock and the role of clocks in the physiology and pathophysiology of metabolic tissues.
authors.affiliation: Department of Cellular and Molecular Physiology, Section of Comparative Medicine, and Integrative Cell Signaling and Neurobiology of Metabolism Program, Yale School of Medicine, New Haven, CT 06520, USA. mindian.li@yale.edu
authors.forename: Min-Dian
authors.initials: MD
authors.lastname: Li
authors.forename: Chao-Min
authors.initials: CM
authors.lastname: Li
authors.forename: Zhong
authors.initials: Z
authors.lastname: Wang
mesh_terms: D056930:ARNTL Transcription Factors / Q000235:genetics / Q000378:metabolism; D000273:Adipose Tissue / Q000378:metabolism / Q000503:physiopathology; D000818:Animals; D001831:Body Temperature; D057906:Circadian Clocks; D004734:Energy Metabolism; D005947:Glucose / Q000378:metabolism; D006801:Humans; D007031:Hypothalamus / Q000378:metabolism / Q000503:physiopathology; D050356:Lipid Metabolism; D008099:Liver / Q000378:metabolism / Q000503:physiopathology; D008659:Metabolic Diseases / Q000235:genetics / Q000378:metabolism / Q000503:physiopathology*; D018482:Muscle, Skeletal / Q000378:metabolism / Q000503:physiopathology; D010179:Pancreas / Q000378:metabolism / Q000503:physiopathology; D012307:Risk Factors
chemical_list: D056930:ARNTL Transcription Factors; D005947:Glucose