title: Twisted structure of a cyclic hexapeptide containing a combination of alternating L-Leu-D-Leu-Aib segments.
abstract: We designed and synthesized a C(2)-symmetric cyclic hexapeptide, cyclo(L-Leu-D-Leu-Aib)(2) (2), which contains L- and D-amino acids and achiral Aib residues. The conformation of 2 was analyzed in the crystalline state and in solution, which was a unique figure-eight-shaped conformation.
authors.affiliation: Division of Organic Chemistry, National Institute of Health Sciences, Tokyo 158-8501, Japan. demizu@nihs.go.jp
authors.forename: Yosuke
authors.initials: Y
authors.lastname: Demizu
authors.forename: Saori
authors.initials: S
authors.lastname: Nagoya
authors.forename: Mitsunobu
authors.initials: M
authors.lastname: Doi
authors.forename: Yukiko
authors.initials: Y
authors.lastname: Sato
authors.forename: Masakazu
authors.initials: M
authors.lastname: Tanaka
authors.forename: Masaaki
authors.initials: M
authors.lastname: Kurihara
mesh_terms: D000596:Amino Acids / Q000737:chemistry*; D000621:Aminoisobutyric Acids / Q000737:chemistry*; D008958:Models, Molecular; D009842:Oligopeptides / Q000737:chemistry*; D010456:Peptides, Cyclic / Q000737:chemistry*; D011487:Protein Conformation
chemical_list: D000596:Amino Acids; D000621:Aminoisobutyric Acids; D009842:Oligopeptides; D010456:Peptides, Cyclic; C100049:2-aminoisobutyric acid