title: The Seville expert workshop for progress in posttransplant lymphoproliferative disorders.
abstract: : Posttransplant lymphoproliferative disorders (PTLDs) are associated with significant morbidity and mortality among solid-organ transplant patients, but approaches to diagnosis and management vary considerably. An international multidisciplinary panel evaluated current understanding of risk factors and classification systems and developed recommendations to aid in PTLD prevention. We considered evidence on PTLD risk factors including Epstein-Barr virus serostatus and immunosuppression and identified knowledge gaps for future research. Recommendations address prophylactic and preemptive strategies to minimize PTLD development, including modulation of immunosuppression and antiviral drug regimens. Finally, new classification criteria were outlined that may help facilitate standardized reporting and improve our understanding of PTLD.
authors.affiliation: Nephrology and Transplantation Service, Hôpital Saint-Louis, Paris, France. denis.glotz@sls.aphp.fr
authors.forename: Denis
authors.initials: D
authors.lastname: Glotz
authors.forename: Jeremy R
authors.initials: JR
authors.lastname: Chapman
authors.forename: Vikas R
authors.initials: VR
authors.lastname: Dharnidharka
authors.forename: Douglas W
authors.initials: DW
authors.lastname: Hanto
authors.forename: Maria C R
authors.initials: MC
authors.lastname: Castro
authors.forename: Hans H
authors.initials: HH
authors.lastname: Hirsch
authors.forename: Véronique
authors.initials: V
authors.lastname: Leblond
authors.forename: Aneesh K
authors.initials: AK
authors.lastname: Mehta
authors.forename: Bruno
authors.initials: B
authors.lastname: Moulin
authors.forename: Antonio
authors.initials: A
authors.lastname: Pagliuca
authors.forename: Julio
authors.initials: J
authors.lastname: Pascual
authors.forename: Alan B
authors.initials: AB
authors.lastname: Rickinson
authors.forename: Francesco P
authors.initials: FP
authors.lastname: Russo
authors.forename: Ralf U
authors.initials: RU
authors.lastname: Trappe
authors.forename: Angela C
authors.initials: AC
authors.lastname: Webster
authors.forename: Andreas O
authors.initials: AO
authors.lastname: Zuckermann
authors.forename: Thomas G
authors.initials: TG
authors.lastname: Gross
mesh_terms: D020031:Epstein-Barr Virus Infections / Q000150:complications; D006801:Humans; D007165:Immunosuppression Therapy / Q000009:adverse effects; D008232:Lymphoproliferative Disorders / Q000145:classification / Q000209:etiology* / Q000517:prevention & control; D016377:Organ Transplantation / Q000009:adverse effects*; D012307:Risk Factors; D019562:Viral Load