title: Intracerebroventricular injection of orexin-2 receptor antagonist promotes REM sleep.
abstract: Orexins are important regulators of sleep-wakefulness (S-W). Rats were intracerebroventricularly (ICV) administered selective orexin-2 receptor antagonist, TCS-OX2-29. There was decreased wakefulness due to a decrease in the average wake episode duration and an increased REM sleep due to an increase in the number of REM episodes, indicating an inhibitory role of the central orexin-2 receptors on REM sleep generation.
authors.affiliation: Department of Physiology, All India Institute of Medical Sciences, Ansari Nagar, New Delhi 110029, India. basheer91@gmail.com
authors.forename: Basheer Ahamad
authors.initials: BA
authors.lastname: Kummangal
authors.forename: Deependra
authors.initials: D
authors.lastname: Kumar
authors.forename: Hruda Nanda
authors.initials: HN
authors.lastname: Mallick
mesh_terms: D000818:Animals; D007276:Injections, Intraventricular; D007546:Isoquinolines / Q000008:administration & dosage*; D008297:Male; D064446:Orexin Receptors; D011725:Pyridines / Q000008:administration & dosage*; D051381:Rats; D017207:Rats, Sprague-Dawley; D017208:Rats, Wistar; D043562:Receptors, G-Protein-Coupled / Q000037:antagonists & inhibitors* / Q000378:metabolism; D018013:Receptors, Neuropeptide / Q000037:antagonists & inhibitors* / Q000378:metabolism; D012895:Sleep, REM / Q000187:drug effects*; D013997:Time Factors; D014851:Wakefulness / Q000187:drug effects
chemical_list: C572065:1-(3,4-dihydro-6,7-dimethoxy-2(1H)-isoquinolinyl)-3,3-dimethyl-2-((4-pyridinylmethyl)amino)-1-butanone; D007546:Isoquinolines; D064446:Orexin Receptors; D011725:Pyridines; D043562:Receptors, G-Protein-Coupled; D018013:Receptors, Neuropeptide