title: No impact of rifamycin selection on tuberculosis treatment outcome in HIV coinfected patients.
abstract: Rifabutin has been substituted for rifampicin when treating tuberculosis (TB)/HIV coinfection. However, despite reports of anti-TB treatment failure and acquired rifamycin resistance, long-term clinical outcome data are lacking. Observational analyses performed in a UK TB/HIV cohort demonstrated no difference in severe adverse events, anti-TB treatment completion, relapse frequency or subsequent rifamycin resistance when rifampicin and rifabutin were compared, using different combinations of antiretroviral therapy. Our data support the wider use of rifabutin in TB/HIV coinfection.
authors.affiliation: Centre for Respiratory Medicine bDepartment of Infectious Diseases, Royal Free Hospital, London, UK. richa.singh@nhs.net
authors.forename: Richa
authors.initials: R
authors.lastname: Singh
authors.forename: Neal
authors.initials: N
authors.lastname: Marshall
authors.forename: Colette J
authors.initials: CJ
authors.lastname: Smith
authors.forename: Carl J
authors.initials: CJ
authors.lastname: Reynolds
authors.forename: Ronan A
authors.initials: RA
authors.lastname: Breen
authors.forename: Sanjay
authors.initials: S
authors.lastname: Bhagani
authors.forename: Ian
authors.initials: I
authors.lastname: Cropley
authors.forename: Susan
authors.initials: S
authors.lastname: Hopkins
authors.forename: Leonie
authors.initials: L
authors.lastname: Swaden
authors.forename: Margaret A
authors.initials: MA
authors.lastname: Johnson
authors.forename: Marc C
authors.initials: MC
authors.lastname: Lipman
mesh_terms: D017088:AIDS-Related Opportunistic Infections / Q000188:drug therapy*; D000328:Adult; D000995:Antitubercular Agents / Q000627:therapeutic use*; D060085:Coinfection; D024881:Drug Resistance, Bacterial; D005260:Female; D015658:HIV Infections / Q000188:drug therapy; D006801:Humans; D008297:Male; D012189:Retrospective Studies; D017828:Rifabutin / Q000627:therapeutic use*; D012294:Rifamycins / Q000627:therapeutic use*; D016896:Treatment Outcome; D014397:Tuberculosis, Pulmonary / Q000188:drug therapy*
chemical_list: D000995:Antitubercular Agents; D012294:Rifamycins; D017828:Rifabutin; C023808:rifamycin SV