title: Gastrostomy use in motor neurone disease (MND): a review, meta-analysis and survey of current practice.
abstract: Abstract   Gastrostomy feeding is commonly used to support MND patients with dysphagia. In this paper we review three main methods of gastrostomy insertion (PEG, RIG, PIG); conduct a meta-analysis of mortality data following gastrostomy; and present a survey of current practice. A review of the literature revealed a lack of high quality evidence to indicate the optimal method and timing for gastrostomy insertion in patients with MND. A survey of 20 MND clinics demonstrated a clinic-based variability of gastrostomy practices due to factors such as clinician preference, availability of method, and patient respiratory function. The meta-analysis demonstrated that the estimate of the absolute difference in mortality rates was 2.1% higher for PEG (- 6.3%, + 11.2%), suggesting that RIG and PIG methods may be safer than PEG. These results and observations highlight the need for more research to evaluate and compare the safety of the differerent gastrostomy insertion methods in MND care.
authors.affiliation: Academic Neurology Unit, Department of Neuroscience, Sheffield Institute for Translational Neuroscience, University of Sheffield, Sheffield, UK. t.stavroulakis@sheffield.ac.uk
authors.forename: Theocharis
authors.initials: T
authors.lastname: Stavroulakis
authors.forename: Theresa
authors.initials: T
authors.lastname: Walsh
authors.forename: Pamela J
authors.initials: PJ
authors.lastname: Shaw
authors.forename: Christopher J
authors.initials: CJ
authors.lastname: McDermott
mesh_terms: D015984:Causality; D015897:Comorbidity; D003680:Deglutition Disorders / Q000453:epidemiology* / Q000601:surgery*; D004750:Enteral Nutrition / Q000706:statistics & numerical data*; D005774:Gastrostomy / Q000706:statistics & numerical data*; D006801:Humans; D016472:Motor Neuron Disease / Q000453:epidemiology* / Q000601:surgery*; D010818:Practice Patterns, Physicians' / Q000706:statistics & numerical data*; D015995:Prevalence; D012307:Risk Factors; D016896:Treatment Outcome