title: [Expression profile of miRNAs in APP swe/PSΔE9 transgenic mice].
abstract: OBJECTIVE
  To observe the changes of miRNA expression profiles in APPswe/PSδE9 transgenic mice and explore the possible roles of miRNA in the pathogenesis of Alzheimer's disease.
  
  
  METHODS
  Using miRNA chip technique, we examined the miRNA expression in the brain tissue of 6-month-old APPswe/PSδE9 transgenic mice, with age-matched wild-type mice as the control group.
  
  
  RESULTS
  Twelve miRNAs showed differential expressions by more than two folds in APPswe/PSδE9 transgenic mice, namely miRNA-135a, miRNA-135a-2*, miRNA-298, miRNA-466b-3p, miR-669-3p, miR-142-5p, miR-144, miR-466f-3p, miR-466g, miR-200a, miR-200b and miR-96. Five miRNAs were significantly down-regulated in the transgenic mice, including miRNA-135a, miRNA-135a-2*, miRNA-298, miRNA-466b-3p, and miR-669-3p.
  
  
  CONCLUSIONS
  The 5 down- regulated miRNA may play important roles in the pathogenesis of AD in APPswe/PSδE9 transgenic mice.
authors.affiliation: Department of Neurology, Third Xiangya Hospital, Central South University, Changsha 410013, China. jiayoudingyu@126.com
authors.forename: Yu
authors.initials: Y
authors.lastname: Ding
authors.forename: Mi
authors.initials: M
authors.lastname: Tian
authors.forename: Jianfeng
authors.initials: J
authors.lastname: Liu
authors.forename: Yanyao
authors.initials: Y
authors.lastname: Deng
authors.forename: Wei
authors.initials: W
authors.lastname: Li
authors.forename: Xialu
authors.initials: X
authors.lastname: Feng
authors.forename: Deren
authors.initials: D
authors.lastname: Hou
mesh_terms: D000544:Alzheimer Disease / Q000235:genetics* / Q000378:metabolism; D000818:Animals; D004195:Disease Models, Animal; D020869:Gene Expression Profiling; D051379:Mice; D008822:Mice, Transgenic; D035683:MicroRNAs / Q000235:genetics* / Q000378:metabolism; D020411:Oligonucleotide Array Sequence Analysis; D059467:Transcriptome
chemical_list: D035683:MicroRNAs