title: Variations in the ceramide profile in different seasons and regions of the body contribute to stratum corneum functions.
abstract: The objective of this study was to clarify variations of the ceramide (CER) profile in human stratum corneum (SC) in different seasons and in different regions of the body and to estimate the contributions of CERs to the SC barrier and water-holding functions. Based on the information that there are great variations of SC functions among body sites, we compared the CER profiles obtained from ten different anatomical sites in healthy Japanese males in four seasons. Not only the physiological parameters of skin but also the CER profile showed body region and seasonal variations. The total CER level, the CER composition and the C34-CER[NS] species displayed strong correlations with the values of transepidermal water loss and capacitance throughout the body. Especially in the cheek, a strong correlation between the capacitance and the CER profile was observed. There were seasonal variations of the CER profile in the lip, upper arm and palm. Our results indicate that regional and seasonal variations of the CER profile may contribute to SC functions.
authors.affiliation: Biological Science Laboratory, Kao Corporation, 2606 Akabane, Ichikai-machi, Haga, Tochigi, Japan. ishikawa.junko1@kao.co.jp
authors.forename: Junko
authors.initials: J
authors.lastname: Ishikawa
authors.forename: Yoshie
authors.initials: Y
authors.lastname: Shimotoyodome
authors.forename: Shotaro
authors.initials: S
authors.lastname: Ito
authors.forename: Yuki
authors.initials: Y
authors.lastname: Miyauchi
authors.forename: Tsutomu
authors.initials: T
authors.lastname: Fujimura
authors.forename: Takashi
authors.initials: T
authors.lastname: Kitahara
authors.forename: Tadashi
authors.initials: T
authors.lastname: Hase
mesh_terms: D000328:Adult; D001830:Body Surface Area; D002518:Ceramides / Q000737:chemistry / Q000378:metabolism*; D002610:Cheek; D025802:Electric Capacitance; D004817:Epidermis / Q000378:metabolism / Q000502:physiology*; D006801:Humans; D007564:Japan; D008297:Male; D012621:Seasons; D014870:Water Loss, Insensible; D014882:Water-Electrolyte Balance
chemical_list: D002518:Ceramides