title: Role of electrolytes disturbances and Na(+)-K(+)-ATPase in cisplatin - induced renal toxicity and effects of ethanolic extract of Cichorium intybus.
abstract: Cisplatin is known by its toxicity by disturbing electrolytes homeostasis. Thus we aimed to find out the role of herbal plant Cichorium intybus on Cisplatin - induced toxicity. 24 male Albino Wistar rats were randomly divided into 4 groups: Group I is termed as untreated control; Group II is Cisplatin control and received 3 mg/ kg b.w.; i.p.; Group III received C. intybus ethanolic extract at a dose of 500 mg/kg b.w. orally for 10 consecutive days and Group IV is Cisplatin + C. intybus pretreated group.  C. intybus is given 30 minutes prior to Cisplatin. Cisplatin - induced electrolytes disturbances is indicated by increase Intra - erythrocyte sodium content, decreased plasma magnesium, calcium and Intra-erythrocyte Na(+)-K(+)-ATPase which implicates the renal toxicity. At a dose of 500 mg/kg b.w. of C. Intybus pretreatment showed partial counter action on the electrolytes imbalances and Na(+)-K(+)-ATPase activity.
authors.affiliation: Department of Biochemistry, University of Karachi, Karachi, Pakistan. shafaqnoori@hotmail.com
authors.forename: Shafaq
authors.initials: S
authors.lastname: Noori
authors.forename: Tabassum
authors.initials: T
authors.lastname: Mahboob
mesh_terms: D000284:Administration, Oral; D000818:Animals; D002118:Calcium / Q000097:blood; D018651:Cichorium intybus / Q000737:chemistry; D002945:Cisplatin; D004195:Disease Models, Animal; D004573:Electrolytes / Q000097:blood*; D004912:Erythrocytes / Q000187:drug effects* / Q000201:enzymology; D000431:Ethanol / Q000737:chemistry*; D006706:Homeostasis; D007674:Kidney Diseases / Q000097:blood / Q000139:chemically induced / Q000188:drug therapy* / Q000201:enzymology; D008274:Magnesium / Q000097:blood; D008297:Male; D035261:Plant Components, Aerial; D010936:Plant Extracts / Q000008:administration & dosage / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D010946:Plants, Medicinal; D020011:Protective Agents / Q000008:administration & dosage / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D012964:Sodium / Q000097:blood; D000254:Sodium-Potassium-Exchanging ATPase / Q000097:blood*; D012997:Solvents / Q000737:chemistry*
chemical_list: D004573:Electrolytes; D010936:Plant Extracts; D020011:Protective Agents; D012997:Solvents; D000431:Ethanol; D012964:Sodium; D000254:Sodium-Potassium-Exchanging ATPase; D008274:Magnesium; D002945:Cisplatin; D002118:Calcium