title: Gait pattern and lower extremity alignment in children with Morquio syndrome.
abstract: The gait in children with Morquio syndrome (MPS IV) has not been previously described. We reviewed the charts, gait analysis reports, and radiographs of nine children with no previous lower extremity surgery. Children with MPS IV had a slower walking speed, reduced cadence, and reduced stride length as compared with normal (P<0.05). There was increased knee flexion, genu valgus, and external tibial torsion during stance (P<0.05). Kinetics showed that knee varus moment was increased (P<0.05). There was a strong correlation between genu valgus measured on gait analysis and standing radiographs (r=0.89).
authors.affiliation: Department of Orthopaedics, Nemours/Alfred I. duPont Hospital for Children, Wilmington, Delaware 19899, USA.
authors.forename: Arjun A
authors.initials: AA
authors.lastname: Dhawale
authors.forename: Chris
authors.initials: C
authors.lastname: Church
authors.forename: John
authors.initials: J
authors.lastname: Henley
authors.forename: Laurens
authors.initials: L
authors.lastname: Holmes
authors.forename: Mihir M
authors.initials: MM
authors.lastname: Thacker
authors.forename: William G
authors.initials: WG
authors.lastname: Mackenzie
authors.forename: Freeman
authors.initials: F
authors.lastname: Miller
mesh_terms: D002648:Child; D005684:Gait; D006801:Humans; D038061:Lower Extremity Deformities, Congenital / Q000209:etiology / Q000503:physiopathology*; D009085:Mucopolysaccharidosis IV / Q000150:complications / Q000503:physiopathology*; D012189:Retrospective Studies