title: Primary cauda equina lymphoma treated with high-dose methotrexate.
abstract: A 69-year-old man presented with a very rare case of primary central nervous system lymphoma originating in the cauda equina manifesting as progressive paraparesis. The patient underwent a biopsy, and was treated with intravenous high-dose (3.5 g/m(2)) methotrexate chemotherapy and local irradiation. Histological study revealed large B cell type lymphoma. Follow-up magnetic resonance imaging showed complete remission of the lesion, but the patient died of pneumonia at 18 months after the initial onset without tumor recurrence, so the efficacy of this strategy remains unknown.
authors.affiliation: Department of Neurosurgery, Hokkaido University Graduate School of Medicine, Sapporo, Hokkaido, Japan. jzesso801@yahoo.co.jp
authors.forename: Motoyuki
authors.initials: M
authors.lastname: Iwasaki
authors.forename: Kazutoshi
authors.initials: K
authors.lastname: Hida
authors.forename: Shunsuke
authors.initials: S
authors.lastname: Yano
authors.forename: Takeshi
authors.initials: T
authors.lastname: Aoyama
authors.forename: Sadahiro
authors.initials: S
authors.lastname: Kaneko
authors.forename: Yoshinobu
authors.initials: Y
authors.lastname: Iwasaki
mesh_terms: D000368:Aged; D000964:Antimetabolites, Antineoplastic / Q000008:administration & dosage / Q000627:therapeutic use*; D002420:Cauda Equina / Q000473:pathology* / Q000601:surgery; D003131:Combined Modality Therapy; D017809:Fatal Outcome; D006801:Humans; D006987:Hypesthesia / Q000209:etiology; D007796:Laminectomy; D016403:Lymphoma, Large B-Cell, Diffuse / Q000150:complications / Q000188:drug therapy* / Q000532:radiotherapy / Q000601:surgery; D008279:Magnetic Resonance Imaging; D008297:Male; D008727:Methotrexate / Q000008:administration & dosage / Q000627:therapeutic use*; D020335:Paraparesis / Q000209:etiology; D010524:Peripheral Nervous System Neoplasms / Q000150:complications / Q000188:drug therapy* / Q000532:radiotherapy / Q000601:surgery; D011014:Pneumonia / Q000150:complications; D011128:Polyradiculopathy / Q000209:etiology; D018714:Radiotherapy, Adjuvant; D012074:Remission Induction
chemical_list: D000964:Antimetabolites, Antineoplastic; D008727:Methotrexate