title: Association of serum gamma-glutamyltransferase with arterial stiffness in established coronary artery disease.
abstract: Serum gamma-glutamyltransferase (GGT) has been reported to predict vascular risk. We enrolled 978 patients (507 men and 471 women) with established coronary artery disease (CAD). The GGT, brachial-ankle pulse wave velocity ([baPWV] to assess arterial stiffness), and conventional risk factors were evaluated. The means of baPWV tend to increase in both genders according to GGT tertiles. Body mass index, GGT, logarithmical (systolic blood pressure [LnSBP]), uric acid (UA), total bilirubin, Ln (cholinesterase), and Ln (total cholesterol) were correlated with baPWV in men in a multivariate model. However, only GGT, LnSBP, UA, and Ln (high-density lipoprotein cholesterol) were correlated with baPWV in women. The GGT was a significant determinant for increased baPWV both in men (β = 0.017; P < .001) and in women (β = 0.015; P < .001). In conclusion, GGT was independently associated with increased arterial stiffness both in men and in women with established CAD.
authors.affiliation: Department of Neurology, The Third Affiliated Hospital, Sun Yat-Sen University, Guangzhou, China.
authors.forename: Cansheng
authors.initials: C
authors.lastname: Zhu
authors.forename: Zhaojun
authors.initials: Z
authors.lastname: Xiong
authors.forename: Zhenda
authors.initials: Z
authors.lastname: Zheng
authors.forename: Yanming
authors.initials: Y
authors.lastname: Chen
authors.forename: Xiaoxian
authors.initials: X
authors.lastname: Qian
authors.forename: Xiaohong
authors.initials: X
authors.lastname: Chen
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D055109:Ankle Brachial Index; D015415:Biomarkers; D001794:Blood Pressure / Q000502:physiology*; D003324:Coronary Artery Disease / Q000097:blood* / Q000201:enzymology / Q000503:physiopathology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D063177:Pulse Wave Analysis; D012307:Risk Factors; D059289:Vascular Stiffness; D005723:gamma-Glutamyltransferase / Q000097:blood*
chemical_list: D015415:Biomarkers; D005723:gamma-Glutamyltransferase