title: Perineural tumor spread - Interconnection between spinal and cranial nerves.
abstract: The secondary neoplastic involvement of the cervical plexus in patients with head and neck malignancies is extremely rare. MR examination of the neck revealed the diffuse neoplastic infiltration of the right C2 root, in a 57-year-old patient with several months long pain in the right ear region and a history of the tongue squamous cell carcinoma. Associated perineural tumor spread and consequent distal involvement of great auricular nerve and vagus nerve were evident. Best of our knowledge, this is the first reported involvement of the cervical plexus in patients with head and neck cancers, associated with the clearly documented interconnection between the cervical plexus and cranial nerves via great auricular nerve.
authors.affiliation: University of Novi Sad, School of Medicine, Institute of Oncology, Diagnostic Imaging Center, Institutski put 4, 21204 Sremska Kamenica, Serbia. dusko.b.kozic@gmail.com
authors.forename: Duško
authors.initials: D
authors.lastname: Kozić
authors.forename: Vesna
authors.initials: V
authors.lastname: Njagulj
authors.forename: Jelena Popadić
authors.initials: JP
authors.lastname: Gaćeša
authors.forename: Robert
authors.initials: R
authors.lastname: Semnic
authors.forename: Nataša
authors.initials: N
authors.lastname: Prvulović
mesh_terms: D002294:Carcinoma, Squamous Cell / Q000000981:diagnostic imaging / Q000473:pathology* / Q000601:surgery; D002465:Cell Movement; D002572:Cervical Plexus / Q000473:pathology*; D003131:Combined Modality Therapy; D004433:Earache / Q000209:etiology; D006801:Humans; D008279:Magnetic Resonance Imaging; D008875:Middle Aged; D009361:Neoplasm Invasiveness / Q000175:diagnosis / Q000473:pathology*; D010525:Peripheral Nerves / Q000473:pathology*; D011859:Radiography; D014062:Tongue Neoplasms / Q000000981:diagnostic imaging / Q000473:pathology* / Q000601:surgery; D014630:Vagus Nerve / Q000473:pathology*