title: Role of the Na(+)/H(+) exchanger on the development of diabetes mellitus and its chronic complications.
abstract: Micro- and macrovascular complications are the main cause of morbidity and mortality in diabetes mellitus. The Na(+)/H(+) exchanger (NHE) is a family of proteins which exchange Na(+) for H(+) according to their concentration gradients in an electroneutral manner. The exchanger also plays a key role in several other cellular functions including proliferation, differentiation, apoptosis, migration, and cytoskeletal organization. Since not much is known on the relationship between NHE and diabetes mellitus, this review outlines the contribution of NHE to chronic complications of diabetes mellitus, such as diabetic nephropathy; diabetic cardiomyopathy.
authors.affiliation: Department of Cardiac Care Unit, The First Affiliated Hospital of Harbin Medical University, Harbin 150001, China.
authors.forename: Yan-Ming
authors.initials: YM
authors.lastname: Sun
authors.forename: Ying
authors.initials: Y
authors.lastname: Su
authors.forename: Jia
authors.initials: J
authors.lastname: Li
authors.forename: Ye
authors.initials: Y
authors.lastname: Tian
authors.forename: Lan-Feng
authors.initials: LF
authors.lastname: Wang
mesh_terms: D003920:Diabetes Mellitus / Q000378:metabolism*; D058065:Diabetic Cardiomyopathies / Q000378:metabolism*; D003928:Diabetic Nephropathies / Q000378:metabolism*; D006801:Humans; D017923:Sodium-Hydrogen Exchangers / Q000378:metabolism*
chemical_list: D017923:Sodium-Hydrogen Exchangers