title: Pyrrole-imidazole polyamides distinguish between double-helical DNA and RNA.
abstract: Groove specificity: pyrrole-imidazole polyamides are well-known for their specific interactions with the minor groove of DNA. However, polyamides do not show similar binding to duplex RNA, and a structural rationale for the molecular-level discrimination of nucleic acid duplexes by minor-groove-binding ligands is presented.
authors.affiliation: Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, 91125, USA.
authors.forename: David M
authors.initials: DM
authors.lastname: Chenoweth
authors.forename: Jordan L
authors.initials: JL
authors.lastname: Meier
authors.forename: Peter B
authors.initials: PB
authors.lastname: Dervan
mesh_terms: D001665:Binding Sites; D004247:DNA / Q000737:chemistry* / Q000378:metabolism; D007093:Imidazoles / Q000737:chemistry* / Q000378:metabolism; D008958:Models, Molecular; D009690:Nucleic Acid Conformation; D009757:Nylons / Q000737:chemistry* / Q000378:metabolism; D011758:Pyrroles / Q000737:chemistry* / Q000378:metabolism; D012313:RNA / Q000737:chemistry* / Q000378:metabolism
chemical_list: D007093:Imidazoles; D009757:Nylons; D011758:Pyrroles; D012313:RNA; C029899:imidazole; D004247:DNA