title: [Antiherpetic activity of netropsin derivatives as tested in experiments in laboratory animals].
abstract: Two dimeric netropsin derivatives (Lys-bis-Nt 15Lys-bis-Nt) were comprehensively tested for antiviral and toxic activity in cell cultures and laboratory animals. The two compounds were found to provide effective and selective inhibition of reproduction of herpes simplex I both in cell culture Vero E6 and in brain of infected white mice, thereby increasing the survival rate and mean life expectation of treated animals as compared to control.
authors.forename: V L
authors.initials: VL
authors.lastname: Andronova
authors.forename: S L
authors.initials: SL
authors.lastname: Grokhovskiĭ
authors.forename: P G
authors.initials: PG
authors.lastname: Deriabin
authors.forename: G V
authors.initials: GV
authors.lastname: Gurskiĭ
authors.forename: G A
authors.initials: GA
authors.lastname: Galegov
authors.forename: D K
authors.initials: DK
authors.lastname: L'vov
mesh_terms: D000818:Animals; D000998:Antiviral Agents / Q000494:pharmacology; D001921:Brain / Q000187:drug effects / Q000821:virology*; D002522:Chlorocebus aethiops; D006561:Herpes Simplex / Q000188:drug therapy / Q000821:virology; D018259:Herpesvirus 1, Human / Q000187:drug effects*; D006801:Humans; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D009429:Netropsin / Q000031:analogs & derivatives / Q000494:pharmacology; D014709:Vero Cells
chemical_list: D000998:Antiviral Agents; D009429:Netropsin