title: Effects of single bout of very high-intensity exercise on metabolic health biomarkers in overweight/obese sedentary men.
abstract: OBJECTIVE
  This study aimed to investigate the effects of a single session of sprint interval training (SIT) and a single extended sprint (ES), matched for total work, on metabolic health biomarkers.
  
  
  METHODS
  Ten overweight/obese men aged 26.9±6.2years participated. Following a pre-trial incremental exercise test and SIT familiarization, each participant undertook three 2-day trials in randomized order. On Day 1 participants either undertook no exercise (CON), four maximal 30-s sprints, with 4.5min recovery between each (SIT), or a single maximal extended sprint (ES) matched with SIT for work done. On Day 2, participants had a fasting blood sample taken, undertook an oral glucose tolerance test to determine insulin sensitivity index (ISI), and had blood pressure measured.
  
  
  RESULTS
  Total work done during exercise did not differ between SIT and ES (61.7±2.9 vs. 61.3±2.8kJ; p=0.741). Mean power was higher in SIT than ES (518±21 vs. 306±16W, p<0.0005), resulting in a shorter high-intensity exercise duration in SIT (120±0 vs. 198±10s, p<0.0005). ISI was 44.6% higher following ES than CON (9.4±2.1 vs. 6.5±1.3; p=0.022), but did not differ significantly between SIT and CON (6.6±0.9 vs. 6.5±1.3; p=0.208). However, on the day following exercise fat oxidation in the fasted state was increased by 63% and 38%, compared to CON, in SIT and ES, respectively (p<0.05 for both), with a concomitant reduction in carbohydrate oxidation (p<0.05).
  
  
  CONCLUSIONS
  A single ES, which may represent a more time-efficient alternative to SIT, can increase insulin sensitivity and increase fat oxidation in overweight overweight/obese sedentary men.
authors.affiliation: Institute of Cardiovascular and Medical Sciences, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow G12 8TA, UK.
authors.forename: Laura J
authors.initials: LJ
authors.lastname: Whyte
authors.forename: Carrie
authors.initials: C
authors.lastname: Ferguson
authors.forename: John
authors.initials: J
authors.lastname: Wilson
authors.forename: Robert A
authors.initials: RA
authors.lastname: Scott
authors.forename: Jason M R
authors.initials: JM
authors.lastname: Gill
mesh_terms: D000328:Adult; D001786:Blood Glucose / Q000378:metabolism; D002153:Calorimetry, Indirect; D002784:Cholesterol / Q000097:blood; D015444:Exercise / Q000502:physiology*; D005951:Glucose Tolerance Test; D006801:Humans; D007328:Insulin / Q000097:blood; D007333:Insulin Resistance / Q000502:physiology*; D008297:Male; D009765:Obesity / Q000097:blood / Q000378:metabolism*; D057185:Sedentary Behavior; D014280:Triglycerides / Q000097:blood
chemical_list: D001786:Blood Glucose; D007328:Insulin; D014280:Triglycerides; D002784:Cholesterol