title: Post-assembly derivatization of electrospun nanofibers via strain-promoted azide alkyne cycloaddition.
abstract: A primary amine-derivatized 4-dibenzocyclooctynol (DIBO) was used to initiate the ring-opening polymerization of poly(γ-benzyl-L-glutamate) (DIBO-PBLG). This initiator yields well-defined PBLG polymers functionalized with DIBO at the chain termini. The DIBO end group further survives an electrospinning process that yields nanofibers that were then derivatized post-assembly with azide-functionalized gold nanoparticles. The availability of DIBO on the surface of the fibers is substantiated by fluorescence, SEM, and TEM measurements. Post-assembly functionalization of nanofiber constructs with bioactive groups can be facilitated easily using this process.
authors.affiliation: Department of Polymer Science, The University of Akron, Akron, Ohio 44325, USA.
authors.forename: Jukuan
authors.initials: J
authors.lastname: Zheng
authors.forename: Kaiyi
authors.initials: K
authors.lastname: Liu
authors.forename: Darrell H
authors.initials: DH
authors.lastname: Reneker
authors.forename: Matthew L
authors.initials: ML
authors.lastname: Becker
mesh_terms: D000480:Alkynes / Q000138:chemical synthesis* / Q000737:chemistry; D001386:Azides / Q000138:chemical synthesis* / Q000737:chemistry; D003500:Cyclization; D055664:Electrochemical Techniques; D015394:Molecular Structure; D057139:Nanofibers / Q000737:chemistry*; D011099:Polyglutamic Acid / Q000031:analogs & derivatives / Q000737:chemistry
chemical_list: D000480:Alkynes; D001386:Azides; C003172:poly-gamma-benzyl-L-glutamate; D011099:Polyglutamic Acid