title: Prognostic value of telomere length in acute coronary syndrome.
abstract: Telomere and telomerase are involved in cellular and organismal ageing and have been related to human diseases. Coronary artery disease is one of the most common age-related health problems in developed countries. Nevertheless, the specific role of cellular ageing in this process is still unclear. In this study, we analyze the possible prognostic value of telomere length and telomerase polymorphisms in a population of 150 middle aged males (mean age 62 ± 7) admitted for acute coronary syndrome who were followed up for more than 600 days. Peripheral blood samples were obtained and relative and comparative qPCR was used to measure telomere length and real time PCR to study the polymorphisms. Two prognostic combined events were defined. Long telomere length was revealed as an independent predictor (protector) of combined event presentation during long term follow up in our patients.
authors.affiliation: IBSAL-University Hospital of Salamanca, Department of Cardiology, Salamanca, Spain. jangel.perezrivera@gmail.com
authors.forename: Jose-Angel
authors.initials: JA
authors.lastname: Perez-Rivera
authors.forename: Pedro
authors.initials: P
authors.lastname: Pabon-Osuna
authors.forename: Clara
authors.initials: C
authors.lastname: Cieza-Borrella
authors.forename: Francisco
authors.initials: F
authors.lastname: Martin-Herrero
authors.forename: Jose-Ramon
authors.initials: JR
authors.lastname: Gonzalez-Porras
authors.forename: Rogelio
authors.initials: R
authors.lastname: Gonzalez-Sarmiento
mesh_terms: D054058:Acute Coronary Syndrome / Q000175:diagnosis / Q000378:metabolism*; D000368:Aged; D000375:Aging; D002318:Cardiovascular Diseases / Q000378:metabolism; D016922:Cellular Senescence; D006801:Humans; D008297:Male; D008875:Middle Aged; D008954:Models, Biological; D016133:Polymerase Chain Reaction / Q000379:methods; D011110:Polymorphism, Genetic; D011379:Prognosis; D019098:Telomerase / Q000235:genetics / Q000378:metabolism; D016615:Telomere / Q000648:ultrastructure*; D013997:Time Factors
chemical_list: D019098:Telomerase