title: Prognostic significance of fibroblastic foci in usual interstitial pneumonia and non-specific interstitial pneumonia.
abstract: OBJECTIVE
  Fibroblastic foci (FF) composed of an accumulation of fibroblasts or myofibroblasts may be related to the progression of pulmonary fibrosis leading to respiratory insufficiency. Several studies have shown that the number of FF is a significant prognostic factor in usual interstitial pneumonia (UIP). The purpose of the present study was to examine whether the extent of FF is related to impairment of respiratory function and prognosis in patients with biopsy-proven fibrosing interstitial pneumonia, including UIP and fibrotic non-specific interstitial pneumonia (fNSIP).
  
  
  METHODS
  Fifty patients with histologically confirmed interstitial pneumonia including UIP or fNSIP were investigated, and correlations between FF and pulmonary function were evaluated. FF area was calculated as the proportion of total area (%FF) and the number of FF (FF/cm(2)) in the whole histological specimen from each patient.
  
  
  RESULTS
  The UIP group showed significantly higher %FF and FF/cm(2) than the fNSIP group. When UIP and fNSIP patients were analysed together, the group of patients who had died (death group) revealed significantly higher %FF and FF/cm(2) compared with the group of survivors, and the impairment of vital capacity and diffusing capacity of carbon monoxide was correlated with %FF and FF/cm(2).
  
  
  CONCLUSIONS
  FF correlated with impaired pulmonary function and may be a useful parameter to predict prognosis in patients with UIP and fNSIP.
authors.affiliation: Departments of Pathology, Fukuoka University School of Medicine, Fukuoka, Japan. haradata@adm.fukuoka-u.ac.jp
authors.forename: Taishi
authors.initials: T
authors.lastname: Harada
authors.forename: Kentaro
authors.initials: K
authors.lastname: Watanabe
authors.forename: Kazuki
authors.initials: K
authors.lastname: Nabeshima
authors.forename: Makoto
authors.initials: M
authors.lastname: Hamasaki
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Iwasaki
mesh_terms: D000368:Aged; D001706:Biopsy; D005260:Female; D005347:Fibroblasts / Q000473:pathology*; D006801:Humans; D054990:Idiopathic Pulmonary Fibrosis / Q000175:diagnosis* / Q000401:mortality / Q000473:pathology; D008168:Lung / Q000473:pathology* / Q000503:physiopathology; D017563:Lung Diseases, Interstitial / Q000175:diagnosis* / Q000401:mortality / Q000473:pathology; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D011653:Pulmonary Diffusing Capacity; D011658:Pulmonary Fibrosis / Q000175:diagnosis / Q000401:mortality / Q000473:pathology; D012189:Retrospective Studies; D015996:Survival Rate