title: [Somatostatin receptors and signaling cascades coupled to them].
abstract: The peptide hormone somatostatin controlling function of CNS and peripheral organs and tissues realizes its regulatory effects via five types of somatostatin receptors (SomR) coupled to heterotrimeric G-proteins. Targets of the hormone action are the enzymes generating second messengers (adenylyl cyclase, phospholipase C, phosphatidylinositol-3-kinase), phosphotyrosine phosphatases, ion channels. The review summarizes and analyzes literature data and results of our investigations dealing with molecular mechanisms of transduction of the somatostatin signal into the cell, selectivity of interaction of SomR with heterotrimeric G-proteins and intracellular effectors as well as of effect of the SomR oligomerization on their functional activity.
authors.forename: A O
authors.initials: AO
authors.lastname: Shpakov
mesh_terms: D000262:Adenylyl Cyclases / Q000378:metabolism / Q000502:physiology; D001921:Brain / Q000201:enzymology / Q000378:metabolism / Q000502:physiology; D015220:Calcium Channels / Q000378:metabolism / Q000502:physiology; D002490:Central Nervous System / Q000201:enzymology / Q000502:physiology; D019204:GTP-Binding Proteins / Q000378:metabolism; D006801:Humans; D058539:Phosphatidylinositol 3-Kinase / Q000378:metabolism / Q000502:physiology; D015221:Potassium Channels / Q000378:metabolism / Q000502:physiology; D017027:Protein Tyrosine Phosphatases / Q000378:metabolism / Q000502:physiology; D017481:Receptors, Somatostatin / Q000378:metabolism* / Q000502:physiology; D015398:Signal Transduction; D013004:Somatostatin / Q000378:metabolism* / Q000502:physiology; D010738:Type C Phospholipases / Q000378:metabolism / Q000502:physiology
chemical_list: D015220:Calcium Channels; D015221:Potassium Channels; D017481:Receptors, Somatostatin; D013004:Somatostatin; D058539:Phosphatidylinositol 3-Kinase; D017027:Protein Tyrosine Phosphatases; D010738:Type C Phospholipases; D019204:GTP-Binding Proteins; D000262:Adenylyl Cyclases