title: Purine metabolites in fibromyalgia syndrome.
abstract: OBJECTIVE
  To evaluate serum purine metabolite concentrations in patients affected by fibromyalgia syndrome (FMS) and the relationships between their levels and FM clinical parameters.
  
  
  METHODS
  Serum purine levels were quantified using LC/UV-vis in 22 fibromyalgic females (according to the American College of Rheumatology classification criteria) and 22 healthy females.
  
  
  RESULTS
  Significantly higher serum inosine, hypoxanthine and xanthine levels (p<0.001) and significantly lower serum adenosine (p<0.05) were detected in the FMS patients vs healthy controls. Our data show a negative correlation between adenosine and Fibromyalgia Impact Questionnaire (FIQ).
  
  
  CONCLUSIONS
  Study results suggest that purines, in particular adenosine and inosine, may be involved in pain transmission in fibromyalgia.
authors.affiliation: Dipartimento di Scienze della Vita e dell'Ambiente, Università di Cagliari, 09042 Monserrato, Cagliari, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Fais
authors.forename: E
authors.initials: E
authors.lastname: Cacace
authors.forename: M
authors.initials: M
authors.lastname: Corda
authors.forename: B
authors.initials: B
authors.lastname: Era
authors.forename: M
authors.initials: M
authors.lastname: Peri
authors.forename: S
authors.initials: S
authors.lastname: Utzeri
authors.forename: V
authors.initials: V
authors.lastname: Ruggiero
mesh_terms: D000241:Adenosine / Q000097:blood; D000328:Adult; D000368:Aged; D016022:Case-Control Studies; D005260:Female; D005356:Fibromyalgia / Q000097:blood* / Q000209:etiology; D006801:Humans; D019271:Hypoxanthine / Q000097:blood; D007288:Inosine / Q000097:blood; D008875:Middle Aged; D011687:Purines / Q000097:blood / Q000378:metabolism*; D012016:Reference Values; D011795:Surveys and Questionnaires; D019820:Xanthine / Q000097:blood
chemical_list: D011687:Purines; D019820:Xanthine; D019271:Hypoxanthine; D007288:Inosine; D000241:Adenosine