title: [Serum APPL1 level is elevated in newly diagnosed cases of type 2 diabetes mellitus].
abstract: OBJECTIVE
  To investigate serum APPL1 level in patients with newly diagnosed type 2 diabetes mellitus (T2DM) and analyze its correlation with body mass index (BMI), waist-to-hip ratio (WHR), blood pressure, fasting plasma glucose, fasting blood insulin, HbA1c, and insulin resistance (HOMA-IR).
  
  
  METHODS
  Serum APPL1 levels were determined using ELISA in 22 normal control subjects and 63 patients with newly diagnosed T2DM, and HOMA-IR of the subjects was calculated using the HOMA model.
  
  
  RESULTS
  The diabetic patients had significantly elevated levels of serum APPL1 compared with the control subjects (85.71∓27.39 vs 64.52∓16.28 pg/ml, P<0.01), with also significantly increased BMI, WHR, SBP, FINS, LgHOMA-IR (P<0.01) and LDL-C (P<0.05) but lowered HDL-C (P<0.01). Fasting serum APPL1 levels were positively correlated with FPG, FINS, and HOMA-IR (r=0.215, 0.297, 0.334, P=0.014, 0.006, 0.002, respectively). In multiple linear regression analysis with APPL1 as the dependent variable, HOMA-IR (β=0.329, P=0.002) was included in the equation.
  
  
  CONCLUSIONS
  Patients with newly diagnosed T2DM have elevated serum APPL1 levels, suggesting the involvement of APPL1 in the development of T2DM.
authors.affiliation: Department of Endocrinology, Second Hospital Affiliated to Xi'an Jiaotong University College of Medicine, Xi'an 710004, China. wangyuhuan369@126.com
authors.forename: Yuhuan
authors.initials: Y
authors.lastname: Wang
authors.forename: Min
authors.initials: M
authors.lastname: Zhang
authors.forename: Lili
authors.initials: L
authors.lastname: Yan
authors.forename: Shimei
authors.initials: S
authors.lastname: Ding
authors.forename: Xuan
authors.initials: X
authors.lastname: Xie
mesh_terms: D048868:Adaptor Proteins, Signal Transducing / Q000097:blood*; D000328:Adult; D001786:Blood Glucose; D016022:Case-Control Studies; D003924:Diabetes Mellitus, Type 2 / Q000097:blood* / Q000175:diagnosis; D005260:Female; D005951:Glucose Tolerance Test; D006801:Humans; D007333:Insulin Resistance; D008297:Male; D008875:Middle Aged
chemical_list: C464801:APPL1 protein, human; D048868:Adaptor Proteins, Signal Transducing; D001786:Blood Glucose