title: Serum apolipoprotein A-V in patients with coronary artery disease and its association with triglyceride.
abstract: BACKGROUND
  Apolipoprotein A-V (ApoA-V) has been shown to play an important role in the metabolism of plasma triglyceride (TG) levels. However, data for the relationship between serum ApoA-V and TG level and the association between ApoA-V levels and the risk of coronary artery disease (CAD) are inconsistent.
  
  
  OBJECTIVE
  To investigate plasma ApoA-V level and its association with TG in patients with CAD determined by angiography.
  
  
  METHODS
  Three hundred forty subjects who underwent coronary angiography (CAG) were classified into a CAD group (n = 211) and a non-CAD group (n = 129) according to the results of their CAG. Serum ApoA-V levels were determined by enzyme-linked immunosorbent assays.
  
  
  RESULTS
  Patients in the CAD group had greater ApoA-V levels than controls (192.0 ± 114.6 ng/mL vs 164.4 ± 107.5 ng/mL, P < .05). The concentration of ApoA-V was positively correlated to TG level (r = 0.229, P < .01). This correlation was more intense in non-CAD group (r = 0.306, P < .01) than in CAD group (r = 0.172, P < .05). ApoA-V was positively associated with Gensini score. However, the contribution of ApoA-V to Gensini score and CAD risk disappeared after adjustment for the TG level.
  
  
  CONCLUSIONS
  The positive correlation between serum ApoA-V and TG differs in strength between control and CAD patients. The correlation between ApoA-V and CAD is confounded by the effect of TG. We speculate that the increase of ApoA-V may be a consequence of compensation for the increased demand for plasma TG hydrolysis.
authors.affiliation: Department of Cardiology, The Second Xiangya Hospital, Central South University, Changsha, 410011 Hunan, PR China.
authors.forename: Yang
authors.initials: Y
authors.lastname: Yang
authors.forename: Shabbir M
authors.initials: SM
authors.lastname: Walijee
authors.forename: Jing
authors.initials: J
authors.lastname: Jin
authors.forename: Shui-ping
authors.initials: SP
authors.lastname: Zhao
authors.forename: Dao-Qan
authors.initials: DQ
authors.lastname: Peng
mesh_terms: D000072040:Apolipoprotein A-V; D001054:Apolipoproteins A / Q000097:blood*; D017023:Coronary Angiography; D003324:Coronary Artery Disease / Q000097:blood* / Q000000981:diagnostic imaging; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012306:Risk; D014280:Triglycerides / Q000097:blood*
chemical_list: C437704:APOA5 protein, human; D000072040:Apolipoprotein A-V; D001054:Apolipoproteins A; D014280:Triglycerides