title: Intravenous infusion of hyperosmotic NaCl solution induces acute cor pulmonale in anesthetized rats.
abstract: Intravenous hyperosmotic NaCl infusion is an effective treatment for circulatory shock. However, a fast infusion rate (2 mL/kg at the rate of 1 mL/s) induces transient hypotension. This response has been reported to be due to decreased total peripheral resistance and/or decreased cardiac performance. Although the hypotension is transient and recovers within 2 min without detrimental consequences, it is important to understand the associated hemodynamics and mechanisms. We found that the hypotensive effect was larger with intravenous NaCl infusion than with intra-aortic infusion, indicating that change in cardiac performance played a more significant role than change in peripheral resistance. NaCl infusion induced an increase in pulmonary vascular resistance and central venous pressure and a decrease in right ventricular dP/dt max, suggesting acute cor pulmonale. Diastolic ventricular crosstalk-induced left ventricular failure was also observed. Hyperosmotic NaCl-induced hypotension was therefore mainly due to a combination of acute cor pulmonale and left ventricular failure.
authors.affiliation: Department of Physiology, Gifu University Graduate School of Medicine, 1-1 Yanagido, Gifu, 501-1194, Japan.
authors.forename: Chikara
authors.initials: C
authors.lastname: Abe
authors.affiliation: Primetech Corporation, 1-3-25 Koishikawa, Bunkyo-ku, Tokyo, 112-0002, Japan.
authors.forename: Yoshiharu
authors.initials: Y
authors.lastname: Tsuru
authors.affiliation: Department of Physiology, Gifu University Graduate School of Medicine, 1-1 Yanagido, Gifu, 501-1194, Japan.
authors.forename: Chihiro
authors.initials: C
authors.lastname: Iwata
authors.affiliation: Primetech Corporation, 1-3-25 Koishikawa, Bunkyo-ku, Tokyo, 112-0002, Japan.
authors.forename: Ryosuke
authors.initials: R
authors.lastname: Ogihara
authors.affiliation: Department of Physiology, Gifu University Graduate School of Medicine, 1-1 Yanagido, Gifu, 501-1194, Japan. zunzunmorita@gmail.com.
authors.forename: Hironobu
authors.initials: H
authors.lastname: Morita
mesh_terms: D000818:Animals; D001794:Blood Pressure / Q000187:drug effects / Q000502:physiology; D002496:Central Venous Pressure / Q000187:drug effects / Q000502:physiology; D006321:Heart / Q000187:drug effects / Q000503:physiopathology; D006333:Heart Failure / Q000139:chemically induced / Q000503:physiopathology; D006439:Hemodynamics / Q000187:drug effects / Q000502:physiology; D007262:Infusions, Intravenous; D008297:Male; D011660:Pulmonary Heart Disease / Q000139:chemically induced* / Q000503:physiopathology; D051381:Rats; D017207:Rats, Sprague-Dawley; D012462:Saline Solution, Hypertonic / Q000633:toxicity*; D012965:Sodium Chloride / Q000633:toxicity*; D014655:Vascular Resistance / Q000187:drug effects / Q000502:physiology; D018487:Ventricular Dysfunction, Left / Q000139:chemically induced / Q000503:physiopathology
chemical_list: D012462:Saline Solution, Hypertonic; D012965:Sodium Chloride