title: The role of adipokines in β-cell failure of type 2 diabetes.
abstract: β-Cell failure coupled with insulin resistance is a key factor in the development of type 2 diabetes. Changes in circulating levels of adipokines, factors released from adipose tissue, form a significant link between excessive adiposity in obesity and both aforementioned factors. In this review, we consider the published evidence for the role of individual adipokines on the function, proliferation, death and failure of β-cells, focusing on those reported to have the most significant effects (leptin, adiponectin, tumour necrosis factor α, resistin, visfatin, dipeptidyl peptidase IV and apelin). It is apparent that some adipokines have beneficial effects whereas others have detrimental properties; the overall contribution to β-cell failure of changed concentrations of adipokines in the blood of obese pre-diabetic subjects will be highly dependent on the balance between these effects and the interactions between the adipokines, which act on the β-cell via a number of intersecting intracellular signalling pathways. We emphasise the importance, and comparative dearth, of studies into the combined effects of adipokines on β-cells.
authors.affiliation: Diabetes and Metabolic Disease Research Group, Research Institute in Healthcare Science, University of Wolverhampton, Wolverhampton WV1 1LY, UK. s.dunmore@wlv.ac.uk
authors.forename: Simon J
authors.initials: SJ
authors.lastname: Dunmore
authors.forename: James E P
authors.initials: JE
authors.lastname: Brown
mesh_terms: D054392:Adipokines / Q000097:blood / Q000378:metabolism*; D000273:Adipose Tissue / Q000276:immunology* / Q000378:metabolism; D000818:Animals; D000073861:Apelin; D016207:Cytokines / Q000097:blood / Q000378:metabolism*; D003924:Diabetes Mellitus, Type 2 / Q000209:etiology* / Q000276:immunology / Q000503:physiopathology; D018819:Dipeptidyl Peptidase 4 / Q000097:blood / Q000378:metabolism; D006801:Humans; D050417:Insulin-Secreting Cells / Q000276:immunology* / Q000378:metabolism; D036341:Intercellular Signaling Peptides and Proteins / Q000097:blood / Q000378:metabolism; D009765:Obesity / Q000503:physiopathology; D010179:Pancreas / Q000276:immunology / Q000378:metabolism / Q000503:physiopathology
chemical_list: C115436:APLN protein, human; D054392:Adipokines; D000073861:Apelin; D016207:Cytokines; D036341:Intercellular Signaling Peptides and Proteins; C042807:DPP4 protein, human; D018819:Dipeptidyl Peptidase 4