title: Melanoma tumor inhibition by tetrachlorido(O,O'-dibutyl-ethylenediamine-N,N'-di-3-propionate)platinum(IV) complex: in vitro and in vivo investigations.
abstract: Tetrachlorido(O,O'-dibutyl-ethylenediamine-N,N'-di-3-propionate)platinum(iv) complex, [PtCl(4)(n-Bu(2)eddp)], was previously found to be effective against fibrosarcoma and glioma cell lines. Here we presented that [PtCl(4)(n-Bu(2)eddp)] strongly reduced the growth of B16 melanoma cells in vitro. Inhibition of cell viability was accompanied with induction of both necrotic and apoptotic cell death. In addition, [PtCl(4)(n-Bu(2)eddp)] concealed the expansion of tumors induced in syngeneic C57Bl/6 mice without visible signs of nephrotoxicity.
authors.affiliation: Institute for Biological Research Sinisa Stankovic, University of Belgrade, Bulevar despota Stefana 142, 11060 Belgrade, Serbia.
authors.forename: Danijela
authors.initials: D
authors.lastname: Maksimović-Ivanić
authors.forename: Sanja
authors.initials: S
authors.lastname: Mijatović
authors.forename: Ivana
authors.initials: I
authors.lastname: Mirkov
authors.forename: Stanislava
authors.initials: S
authors.lastname: Stošić-Grujičić
authors.forename: Djordje
authors.initials: D
authors.lastname: Miljković
authors.forename: Tibor J
authors.initials: TJ
authors.lastname: Sabo
authors.forename: Vladimir
authors.initials: V
authors.lastname: Trajković
authors.forename: Goran N
authors.initials: GN
authors.lastname: Kaluđerović
mesh_terms: D000704:Analysis of Variance; D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology*; D002453:Cell Cycle / Q000187:drug effects; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D002945:Cisplatin / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D008546:Melanoma, Experimental / Q000188:drug therapy*; D051379:Mice; D008810:Mice, Inbred C57BL; D009944:Organoplatinum Compounds / Q000494:pharmacology* / Q000627:therapeutic use
chemical_list: D000970:Antineoplastic Agents; D009944:Organoplatinum Compounds; C581902:tetrachlorido(O,O'-dibutyl-ethylenediamine-N,N'-di-3-propionate)platinum(IV); D002945:Cisplatin