title: Phytochemical screening and antimicrobial activity of Coccinia cordifolia L. plant.
abstract: The medicinal plant, Coccinia cordifolia L. was analyzed for its chemical composition. The antimicrobial activities of the methanol, water, ethanol and ethyl acetate extracts of Coccinia cordifolia L. plant were evaluated against some Gram positive bacteria (Sarcina lutea, Bacillus subtilis and Staphylococcus aureus), Gram negative bacteria (Salmonella typhi, Shigella dysenteriae and Escherichia coli) and fungi (Candida albicans, Aspergillus niger and Penicillium notatum). Chemical analysis showed that the plant is rich in nutrients, especially antioxidant compounds such as total phenol, vitamin C and β-carotene. Phytochemical screening showed that the methanolic extract contains the bioactive constituents such as tannins, saponins, phenols, flavonoids and terpenoids. In the methanolic extract of the plant, promising antimicrobial potential was observed against the tested microorganism. Methanolic extract showed highest activity against Shigella dysenteriae, Escherichia coli, Staphylococcus aureus, and Candida albicans compared to the other extracts. Water extract showed less antimicrobial activity as compared to other extractants.
authors.affiliation: Department of Biochemistry and Molecular Biology, University of Rajshahi, Rajshahi, Bangladesh.
authors.forename: Shahanaz
authors.initials: S
authors.lastname: Khatun
authors.forename: Farzana
authors.initials: F
authors.lastname: Pervin
authors.forename: Mohammad Rezaul
authors.initials: MR
authors.lastname: Karim
authors.forename: Mohammad
authors.initials: M
authors.lastname: Ashraduzzaman
authors.forename: Ahmad
authors.initials: A
authors.lastname: Rosma
mesh_terms: D000085:Acetates / Q000737:chemistry; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D000935:Antifungal Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects / Q000254:growth & development; D019662:Cucurbitaceae / Q000737:chemistry; D000431:Ethanol / Q000737:chemistry; D005658:Fungi / Q000187:drug effects / Q000254:growth & development; D000432:Methanol / Q000737:chemistry; D008826:Microbial Sensitivity Tests; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D010946:Plants, Medicinal; D012997:Solvents / Q000737:chemistry; D014867:Water / Q000737:chemistry
chemical_list: D000085:Acetates; D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D010936:Plant Extracts; D012997:Solvents; D014867:Water; D000431:Ethanol; C007650:ethyl acetate; D000432:Methanol