title: Metachronous clear cell carcinoma of the tongue and kidney: a diagnostically challenging coincidence.
abstract: Clear cell carcinomas (CCCs) account for 1% of carcinomas of the salivary glands. A 63-year-old woman presented with a painless, nonulcerated, nodular mass on the right side of the tongue, without palpable neck nodes. After excision and cryotherapy of the mass, the histologic evaluation revealed CCC. At the age of 55, she had undergone radical nephrectomy for CCC of the kidney which extended into the renal vein (pT3aN0). Although she had remained metastasis-free during the follow-up, the clear cell morphology raised the possibility of late lingual metastasis of the renal CCC. A clinical search for metastases, and a series of immunostainings and analysis of the von Hippel-Lindau gene were therefore performed on paraffin-embedded blocks of both tumors: Primary metachronous CCC of the tongue was diagnosed. This case illustrates the diagnostic challenge posed by CCC of the tongue if there is a history of CCC of the kidney.
authors.affiliation: Division of Oral Medicine, Department of Oral Surgery, Faculty of Dentistry, University of Szeged, Szeged, Hungary. novakpeter77@yahoo.com
authors.forename: Peter
authors.initials: P
authors.lastname: Novak
authors.forename: Farkas
authors.initials: F
authors.lastname: Sükösd
authors.forename: Sandor
authors.initials: S
authors.lastname: Hamar
authors.forename: Istvan
authors.initials: I
authors.lastname: Nemeth
authors.forename: Laszlo
authors.initials: L
authors.lastname: Tiszlavicz
authors.forename: Istvan
authors.initials: I
authors.lastname: Szalay
authors.forename: Istvan
authors.initials: I
authors.lastname: Sonkodi
authors.forename: Bela
authors.initials: B
authors.lastname: Ivanyi
authors.forename: Katalin
authors.initials: K
authors.lastname: Nagy
mesh_terms: D018262:Adenocarcinoma, Clear Cell / Q000175:diagnosis* / Q000473:pathology / Q000628:therapy; D002292:Carcinoma, Renal Cell / Q000473:pathology* / Q000601:surgery; D005260:Female; D006801:Humans; D007680:Kidney Neoplasms / Q000473:pathology* / Q000601:surgery; D008875:Middle Aged; D016609:Neoplasms, Second Primary / Q000175:diagnosis* / Q000473:pathology; D014062:Tongue Neoplasms / Q000175:diagnosis* / Q000473:pathology / Q000628:therapy