title: [Effects of guizhi tang on inflammatory cytokines in myocardial ischemia and hyperlipidemia rats].
abstract: OBJECTIVE
  To explore the effects of Guizhi Tang on the inflammatory cytokines in myocardial ischemia and hyperlipidemia rats.
  
  
  METHODS
  The early changes of hyperlipid and atherosclerosis are caused by utilizing multiple factors including feeding hyperlipid and propylthiouracil and high doses of vitamin D3 for 12 weeks. Sixty male SD rats were randomly divided in to 5 groups: control group, model group, simvastatin group, low-dosage Guizhi Tang group, high-dosage Guizhi Tang group. At the end of six weeks treatment, pituitrin(pit) is abdominal cavity injected every 24 hours for a total of three times. Detecting the serum levels of SES, CRP, NO, SOD, MDA and the content of cardiac muscle tissue SOD, MDA, The expression of TNF-alpha in cardiac muscle tissue was detected by immunohistochemistry.
  
  
  RESULTS
  Guizhi Tang significantly decreased levels of SES, CRP and MAD, increased levels of NO and SOD, Guizhi Tang markedly decreased the level of protein expression of TNF-alpha in cardiac muscle tissue.
  
  
  CONCLUSIONS
  Guizhi Tang may inhibit the proinflammatory factors and oxidation in myocardial ischemia and hyperlipidemia rats.
authors.affiliation: Hebei North University, Zhangjiakou 075000, China.
authors.forename: Hong
authors.initials: H
authors.lastname: Jiao
authors.forename: Jianwei
authors.initials: J
authors.lastname: Ma
authors.forename: Yanjing
authors.initials: Y
authors.lastname: Chen
authors.forename: Dahong
authors.initials: D
authors.lastname: Ju
authors.forename: Lihua
authors.initials: L
authors.lastname: Xiang
authors.forename: Shuqiang
authors.initials: S
authors.lastname: Wang
mesh_terms: D000818:Animals; D002097:C-Reactive Protein / Q000378:metabolism; D016207:Cytokines / Q000378:metabolism*; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D006949:Hyperlipidemias / Q000097:blood / Q000378:metabolism* / Q000473:pathology; D007249:Inflammation / Q000378:metabolism; D008297:Male; D008315:Malondialdehyde / Q000097:blood / Q000378:metabolism; D017202:Myocardial Ischemia / Q000097:blood / Q000378:metabolism* / Q000473:pathology; D009206:Myocardium / Q000378:metabolism / Q000473:pathology; D009569:Nitric Oxide / Q000378:metabolism; D051381:Rats; D017207:Rats, Sprague-Dawley; D013482:Superoxide Dismutase / Q000097:blood / Q000378:metabolism; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism
chemical_list: D016207:Cytokines; D004365:Drugs, Chinese Herbal; D014409:Tumor Necrosis Factor-alpha; C528663:guizhi decoction; D009569:Nitric Oxide; D008315:Malondialdehyde; D002097:C-Reactive Protein; D013482:Superoxide Dismutase