title: Rationale and feasibility of intranasal delivery of drugs to the eustachian tube orifice.
abstract: Intranasal medication for eustachian tube dysfunction (ETD) is an established practice in otolaryngology through the effects of steroids, decongestants, antihistamines or a combination of the above in reducing tubal oedema. The author has previously argued that a double-blind, randomised control trial would be helpful in determining effectiveness of treatment, if a standardised head position, chiefly Mygind or Ragan, was adopted to maximise intranasal drop delivery into the eustachian tube orifice. One recent paper suggests that intranasal treatment is not very effective, but ultimately does not state whether a standardised head position was adopted. Although a large body of evidence supports the hypothesis that the nasal passages are the route to middle ear disease, there is as yet no paper that has been published that has specifically addressed this issue, therefore the author must conclude that evidence to support intranasal treatment for ETD is still lacking and further research is desirable.
authors.affiliation: South West Deanery, Royal Devon and Exeter Hospital, Barrack Rd, Exeter, EX2 5DW, UK. mamunrashid@doctors.net.uk
authors.forename: Mamun
authors.initials: M
authors.lastname: Rashid
mesh_terms: D000281:Administration, Intranasal; D000328:Adult; D002648:Child; D004311:Double-Blind Method; D004427:Ear Diseases / Q000188:drug therapy; D005064:Eustachian Tube / Q000503:physiopathology; D005240:Feasibility Studies; D006257:Head; D006633:Histamine Antagonists / Q000008:administration & dosage*; D006801:Humans; D014663:Nasal Decongestants / Q000008:administration & dosage*; D010033:Otitis Media / Q000188:drug therapy*; D011187:Posture; D012220:Rhinitis / Q000188:drug therapy*; D012965:Sodium Chloride / Q000008:administration & dosage*; D013256:Steroids / Q000008:administration & dosage*
chemical_list: D006633:Histamine Antagonists; D014663:Nasal Decongestants; D013256:Steroids; D012965:Sodium Chloride