title: Meta-analysis shows strong positive association of the TNF-α gene with tumor stage in bladder cancer.
abstract: There is no consensus on the association between the tumor necrosis factor-α (TNF-α) gene promoter -308 A/G single nucleotide polymorphisms and bladder cancer risk. To obtain a more precise estimation of this correlation, we conducted a meta-analysis. The PubMed, MEDLINE, Cochrane Library and China National Knowledge Infrastructure (CNKI) databases were searched for relevant published studies. Seven case-control studies with a total of 1,311 cases and 1,436 controls were identified and analyzed. A notable correlation was observed between the TNF-α genotype and bladder cancer grade (AA+GA vs. GG; odds ratio 1.96, 95% confidence interval 1.37-2.80, p = 0.0002). In summary, this meta-analysis demonstrates that the TNF-α -308 AA+GA genotype may be a marker to the tumor-invasive stage of bladder cancer.
authors.affiliation: Department of Urinary Surgery, Tangdu Hospital, Fourth Military Medical University, Xi'an, China. profyangzengyue@yahoo.cn
authors.forename: Zengyue
authors.initials: Z
authors.lastname: Yang
authors.forename: Yajie
authors.initials: Y
authors.lastname: Lv
authors.forename: Yali
authors.initials: Y
authors.lastname: Lv
authors.forename: Yong
authors.initials: Y
authors.lastname: Wang
mesh_terms: D016022:Case-Control Studies; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D009361:Neoplasm Invasiveness; D009367:Neoplasm Staging; D016017:Odds Ratio; D011110:Polymorphism, Genetic; D020641:Polymorphism, Single Nucleotide; D012306:Risk; D014409:Tumor Necrosis Factor-alpha / Q000235:genetics* / Q000378:metabolism*; D001749:Urinary Bladder Neoplasms / Q000175:diagnosis* / Q000378:metabolism*
chemical_list: D014409:Tumor Necrosis Factor-alpha