title: Evaluation of healing processes of intraosseous defects with and without guided bone regeneration and platelet rich plasma. An animal study.
abstract: BACKGROUND
  In most cases, the natural healing of intrabony defects only leads to restoration of tissue continuity without differentiation and function. However, repair is not regarded to be an optimal treatment method, as confirmed in many clinical cases. Thus it is important to choose a surgical procedure which makes it possible to achieve restitution ad integrum of the bone structure. The choice of the GBR technique is crucial, in terms of the clinical conditions and limitations resulting from the use of a particular material.
  
  
  OBJECTIVE
  The objective of this study has been the analysis of effectiveness of selected surgical treatment techniques of intrabony defects in rabbits.
  
  
  METHODS
  Research was conducted on 36 white rabbits. The operation technique was a criterion of division into 3 groups: BG/BOC (Bio-Oss Collagen(®)+Bio-Gide Perio(®)), BOC/PRP (Bio-Oss Collagen(®)+PRP), C (control group). Qualitative and quantitative histopathological evaluation was carried out after 1, 3, 6 and 12 months.
  
  
  RESULTS
  The highest value of the bone surface area 31.9% (SD 1.8) was achieved in BOC/BG group three months after the implantation, while the lowest was revealed in C - group - 12.5% (SD 1.32) one month following the procedure.
  
  
  CONCLUSIONS
  Upon quantitative histological assessment, the bone tissue presented the most intensive osteogenesis within one month from the application of BOC/PRP, whereas this was observed after the application of BOC/BG in later stages. The application of two regenerative methods influenced the rate, quality and overall treatment of intraosseus defects.
authors.affiliation: Department of Oral Surgery, Silesian Piast Medical University, Wrocław, Poland. marzena.dominiak@wp.pl
authors.forename: Marzena
authors.initials: M
authors.lastname: Dominiak
authors.forename: Katarzyna
authors.initials: K
authors.lastname: Łysiak-Drwal
authors.forename: Leszek
authors.initials: L
authors.lastname: Solski
authors.forename: Bogusława
authors.initials: B
authors.lastname: Żywicka
authors.forename: Zbigniew
authors.initials: Z
authors.lastname: Rybak
authors.forename: Tomasz
authors.initials: T
authors.lastname: Gedrange
mesh_terms: D000818:Animals; D001861:Bone Regeneration; D018786:Bone Substitutes / Q000627:therapeutic use*; D003131:Combined Modality Therapy; D005260:Female; D005264:Femoral Fractures / Q000473:pathology / Q000503:physiopathology* / Q000628:therapy*; D048091:Guided Tissue Regeneration / Q000379:methods*; D006801:Humans; D008297:Male; D017713:Platelet Transfusion / Q000379:methods*; D053657:Platelet-Rich Plasma; D011817:Rabbits; D016896:Treatment Outcome
chemical_list: D018786:Bone Substitutes