title: Atlas of the developing brain of the marmoset monkey constructed using magnetic resonance histology.
abstract: The developmental anatomy of the brain is largely directed by neural-based cues. Despite this knowledge, the developmental trajectory of the primate brain has not yet been fully characterized. To realize this goal, the advance in noninvasive imaging methods and new brain atlases are essential. The common marmoset (Callithrix jacchus), a small New World primate, is widely used in neuroscience research. The recent introduction of transgenic techniques has enabled the marmoset to be used as a genetically modifiable primate model for brain development. Here, a magnetic resonance histology technique involving the use of ultra-high-resolution ex vivo magnetic resonance imaging (MRI) was performed to identify the developmental anatomy of the marmoset brain at different time points from gestational week 8 through to birth. The data allowed the generation of a multidimensional atlas of brain structures at different developmental stages. Furthermore, in utero MRI techniques were developed to noninvasively monitor brain development during the embryonic and fetal stages. The multidimensional atlas and the MRI tools developed herein are anticipated to further our understanding of the developing primate brain.
authors.affiliation: Department of Physiology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Hikishima
authors.forename: K
authors.initials: K
authors.lastname: Sawada
authors.forename: A Y
authors.initials: AY
authors.lastname: Murayama
authors.forename: Y
authors.initials: Y
authors.lastname: Komaki
authors.forename: K
authors.initials: K
authors.lastname: Kawai
authors.forename: N
authors.initials: N
authors.lastname: Sato
authors.forename: T
authors.initials: T
authors.lastname: Inoue
authors.forename: T
authors.initials: T
authors.lastname: Itoh
authors.forename: S
authors.initials: S
authors.lastname: Momoshima
authors.forename: A
authors.initials: A
authors.lastname: Iriki
authors.forename: H J
authors.initials: HJ
authors.lastname: Okano
authors.forename: E
authors.initials: E
authors.lastname: Sasaki
authors.forename: H
authors.initials: H
authors.lastname: Okano
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D001921:Brain / Q000033:anatomy & histology / Q000196:embryology / Q000254:growth & development; D001931:Brain Mapping; D002144:Callithrix / Q000033:anatomy & histology*; D004622:Embryo, Mammalian; D021621:Imaging, Three-Dimensional; D008279:Magnetic Resonance Imaging; D013997:Time Factors