title: [Effect of Korargin on reactivity of isolation aorta of adult and old irradiated rats].
abstract: Introduction to the diet of adult (7-8 months) and old (24-26 months) male rats for 30 days after a single R-irradiation at a dose of 5 Gy of preparation "Korargin" (whose active ingredients are L-arginine, contributing to the prevention of endothelial dysfunction, and inosine) in old irradiated rats significantly increased the relaxation of isolated segments of thoracic aorta by the action of acetylcholine, sodium nitroprusside and insulin. In adults irradiated animals this effect was not observed. Vasoconstriction response of isolated segments of thoracic aorta to norepinephrine was decreased in isolated segments of thoracic aorta by adults and old irradiated rats compared with controls, and application of korargin had no significant effect. Thus, in old irradiated rats, in contrast to adult irradiated animals, the use of korargin increased of vascular sensitiveness to act of endothelial-dependent and endothelial-nondependent vazodilatators, helped to preserve of endothelial function and increase the capacity of vazodilatator potential.
authors.forename: E N
authors.initials: EN
authors.lastname: Gorban'
authors.forename: N V
authors.initials: NV
authors.lastname: Sykalo
authors.forename: E V
authors.initials: EV
authors.lastname: Pod"iachenko
mesh_terms: D000109:Acetylcholine / Q000494:pharmacology; D000284:Administration, Oral; D000367:Age Factors; D000818:Animals; D001013:Aorta, Thoracic / Q000187:drug effects* / Q000378:metabolism / Q000528:radiation effects; D001120:Arginine / Q000494:pharmacology*; D004730:Endothelium, Vascular / Q000187:drug effects* / Q000378:metabolism / Q000528:radiation effects; D005720:Gamma Rays / Q000009:adverse effects; D007288:Inosine / Q000494:pharmacology*; D007328:Insulin / Q000494:pharmacology; D008297:Male; D009599:Nitroprusside / Q000494:pharmacology; D009638:Norepinephrine / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D046509:Tissue Culture Techniques; D014661:Vasoconstriction / Q000187:drug effects*; D014664:Vasodilation / Q000187:drug effects*; D014916:Whole-Body Irradiation
chemical_list: D007328:Insulin; D009599:Nitroprusside; D007288:Inosine; D001120:Arginine; D000109:Acetylcholine; D009638:Norepinephrine