title: Full genomic analysis of a human rotavirus G1P[8] strain isolated in South Korea.
abstract: A rotavirus G1P[8] strain C1-81 was isolated from a 5-month-old female infant admitted to hospital with fever and severe diarrhea in Incheon, South Korea. To investigate its full genomic relatedness and its group, the full genome of strain C1-81 was determined. Based on a full genome classification system, C1-81 was shown to possess the typical Wa-like genotype constellation: G1-P[8]-I1-R1-C1-M1-A1-N1-T1-E1-H1. On the basis of sequence similarities, the strain was shown to be the closest related strain to contemporary human rotavirus strains with recent strains isolated in Asia. This C1-81 strain showed the highest degree of nucleic acid similarity (98.8% and 97%) to G1 B4633-03 and P[8] (Thai-1604 and Dhaka8-02), respectively. This is the first report that group A rotavirus was analyzed with G1P[8] in South Korea. The study of the complete genome of the virus will help understanding of the evolution of rotavirus.
authors.affiliation: Department of Microbiology, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.
authors.forename: Min-Kyu
authors.initials: MK
authors.lastname: Cho
authors.forename: Weon-Hwa
authors.initials: WH
authors.lastname: Jheong
authors.forename: Sung-Geun
authors.initials: SG
authors.lastname: Lee
authors.forename: Chul Jong
authors.initials: CJ
authors.lastname: Park
authors.forename: Kum Hee
authors.initials: KH
authors.lastname: Jung
authors.forename: Soon-Young
authors.initials: SY
authors.lastname: Paik
mesh_terms: D003967:Diarrhea / Q000821:virology; D005260:Female; D016679:Genome, Viral; D005838:Genotype; D006801:Humans; D007223:Infant; D008969:Molecular Sequence Data; D010802:Phylogeny; D012367:RNA, Viral / Q000235:genetics*; D056910:Republic of Korea; D012401:Rotavirus / Q000235:genetics* / Q000302:isolation & purification; D012400:Rotavirus Infections / Q000821:virology; D017422:Sequence Analysis, DNA; D012689:Sequence Homology, Nucleic Acid
chemical_list: D012367:RNA, Viral