title: Development of neurological disease is associated with increased immune activation in simian immunodeficiency virus-infected macaques.
abstract: Simian immunodeficiency virus (SIV) infection of macaques can result in central nervous system disorders, such as meningitis and encephalitis. We studied 10 animals inoculated with brain-derived virus from animals with SIV encephalitis. Over half of the macaques developed SIV-induced neurologic disease. Elevated levels of systemic immune activation were observed to correlate with viral RNA in the cerebral spinal fluid but not with plasma viral load, consistent with a role for SIV in the pathogenesis of neurologic disease.
authors.affiliation: Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA.
authors.forename: Que
authors.initials: Q
authors.lastname: Dang
authors.forename: Sonya
authors.initials: S
authors.lastname: Whitted
authors.forename: Robert M
authors.initials: RM
authors.lastname: Goeken
authors.forename: Jason M
authors.initials: JM
authors.lastname: Brenchley
authors.forename: Kenta
authors.initials: K
authors.lastname: Matsuda
authors.forename: Charles R
authors.initials: CR
authors.lastname: Brown
authors.forename: Bernard A P
authors.initials: BA
authors.lastname: Lafont
authors.forename: Matthew F
authors.initials: MF
authors.lastname: Starost
authors.forename: Ranjini
authors.initials: R
authors.lastname: Iyengar
authors.forename: Ronald J
authors.initials: RJ
authors.lastname: Plishka
authors.forename: Alicia
authors.initials: A
authors.lastname: Buckler-White
authors.forename: Vanessa M
authors.initials: VM
authors.lastname: Hirsch
mesh_terms: D000818:Animals; D008251:Macaca; D009422:Nervous System Diseases / Q000276:immunology* / Q000473:pathology; D016097:Simian Acquired Immunodeficiency Syndrome / Q000276:immunology* / Q000473:pathology