title: Association between multiple cutaneous melanoma and other primary neoplasms.
abstract: BACKGROUND
  The risk of a subsequent cancer is an important issue for patients with melanoma. The development of a second primary cancer in patients with a solitary melanoma has been discussed in several studies. However, to our knowledge, the incidence of second primary cancer (SPC) in patients with multiple primary melanoma (MPM) has not been thoroughly investigated.
  
  
  OBJECTIVE
  To quantify the incidence of SPC in patients with MPM, with the aim of possibly developing further preventive measures.
  
  
  METHODS
  In a retrospective study, 76 patients with MPM were identified from 2155 patients being followed up at our unit.
  
  
  RESULTS
  Of the 76 patients, 12 (16%) developed another neoplasm, with 59% of them having nonmelanoma skin cancer (NMSC), and 41% other noncutaneous cancers. By contrast, only 8% of those with single primary melanoma had other neoplasms (21% of whom had NMSC).
  
  
  CONCLUSIONS
  Patients with MPM, especially men with skin phototype II, have a significantly increased incidence of developing SPC, particularly NMSC. Thus, careful monitoring is essential not only to detect recurrence of the original cancer or development of another primary melanoma, but also development of new malignancies of different types, particularly NMSC.
authors.affiliation: Departments of Dermatology Pathology, University Hospital Spedali Civili, Brescia, Italy. manganoni@spedalicivili.brescia.it
authors.forename: A M
authors.initials: AM
authors.lastname: Manganoni
authors.forename: L
authors.initials: L
authors.lastname: Pavoni
authors.forename: C
authors.initials: C
authors.lastname: Farisoglio
authors.forename: E
authors.initials: E
authors.lastname: Sereni
authors.forename: M
authors.initials: M
authors.lastname: Chiudinelli
authors.forename: P
authors.initials: P
authors.lastname: Calzavara-Pinton
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002648:Child; D005260:Female; D006801:Humans; D015994:Incidence; D008297:Male; D008545:Melanoma / Q000453:epidemiology*; D008875:Middle Aged; D009378:Neoplasms, Multiple Primary / Q000453:epidemiology*; D016609:Neoplasms, Second Primary / Q000453:epidemiology*; D016017:Odds Ratio; D012189:Retrospective Studies; D012307:Risk Factors; D012737:Sex Factors; D012878:Skin Neoplasms / Q000453:epidemiology*; D014481:United States / Q000453:epidemiology; D055815:Young Adult