title: Gastrointestinal stromal tumor of the ampulla of Vater with osteoclastic giant cells, osteoid-like matrix deposition, and aneurysmal bone cyst-like features.
abstract: Gastrointestinal stromal tumors are a heterogeneous group with a wide spectrum of histologic features. We describe the first case of 61-year-old woman who presented gastrointestinal stromal tumors of the ampulla of Vater with osteoclast-like giant cells surrounding osteoid-like material and aneurismal bone cyst-like areas. The phenotype was supported by light microscopy and corroborated by immunohistochemistry analysis. Because of the presence of osteoid-like and aneurismal bone cyst-like components, it is first necessary to make differential diagnosis with other entities such as metastatic osteosarcoma. Our case shows another form of differentiation that has not previously been reported.
authors.affiliation: Department of Pathology, Oncology Hospital, National Medical Center Century XXI. I.M.S.S., Mexico City, Mexico. fcandanedo@hotmail.com
authors.forename: Fernando
authors.initials: F
authors.lastname: Candanedo-Gonzalez
authors.forename: Leslie
authors.initials: L
authors.lastname: Camacho-Rebollar
authors.forename: Candelaria Cordova
authors.initials: CC
authors.lastname: Uscanga
authors.forename: Alejandra Romero
authors.initials: AR
authors.lastname: Utrilla
authors.forename: Maria Eugenia Palmerin
authors.initials: ME
authors.lastname: Bucio
authors.forename: Sandra Sanchez
authors.initials: SS
authors.lastname: Rodriguez
authors.forename: Luis Mora
authors.initials: LM
authors.lastname: Hernandez
mesh_terms: D014670:Ampulla of Vater / Q000473:pathology*; D014408:Biomarkers, Tumor / Q000378:metabolism*; D017824:Bone Cysts, Aneurysmal / Q000473:pathology*; D002454:Cell Differentiation; D003138:Common Bile Duct Neoplasms / Q000473:pathology* / Q000601:surgery; D003937:Diagnosis, Differential; D004386:Duodenum / Q000473:pathology; D005260:Female; D005770:Gastrointestinal Neoplasms / Q000473:pathology* / Q000601:surgery; D046152:Gastrointestinal Stromal Tumors / Q000473:pathology* / Q000601:surgery; D015726:Giant Cells / Q000473:pathology; D006801:Humans; D008875:Middle Aged; D010010:Osteoclasts / Q000473:pathology; D010641:Phenotype; D014057:Tomography, X-Ray Computed
chemical_list: D014408:Biomarkers, Tumor