title: Tianeptine in combination with monoamine oxidase inhibitors for major depressive disorder.
abstract: Major depressive disorder may respond to monotherapy with monoamine oxidase inhibitors (MAOIs) or tianeptine. Literature search showed no reports of MAOIs combined with tianeptine. The method included was clinical case history. A 59-year-old woman had partial improvement of depression with the MAOI tranylcypromine combined with topiramate, trazodone and ziprasidone. The patient had further improvement of depression symptoms after addition of tianeptine. No adverse events were evident. The combination of MAIOs and tianeptine may be effective for refractory major depressive disorder.
authors.affiliation: Department of Psychiatry, Cooper Medical School of Rowan University, NJ, USA. edward.tobe@comcast.net
authors.forename: Edward H
authors.initials: EH
authors.lastname: Tobe
mesh_terms: D003865:Major Depressive Disorder / Q000188:drug therapy*; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D008875:Middle Aged; D008996:Monoamine Oxidase Inhibitors / Q000627:therapeutic use*; D013841:Thiazepines / Q000627:therapeutic use*
chemical_list: D008996:Monoamine Oxidase Inhibitors; D013841:Thiazepines; C050504:tianeptine