title: Calciphylaxis, a diagnostic and therapeutic challenge: report of a successful case.
abstract: Calciphylaxis, also known as calcific uremic arteriolopathy, is a severe complication often observed in patients with hyperparathyroidism secondary to chronic renal failure, which occurs mainly in women. It is characterized by ischemic tissue loss secondary to progressive vascular compromise. This is a rare and severe condition and its pathogenesis is unclear. The best treatment is prevention, especially in order to maintain adequate levels of calcium and phosphorus. We describe a case of this disease in a patient with hyperparathyroidism secondary to chronic renal failure who underwent medical treatment, surgical debridement and total skin autografts, with resolution of symptoms after 6 months.
authors.affiliation: Dermatology Service, Regional Hospital of Presidente Prudente, University of the West Paulista Region, São Paulo, Brazil. eduardoroncada.dermatologia@hotmail.com
authors.forename: Eduardo Vinicius Mendes
authors.initials: EV
authors.lastname: Roncada
authors.forename: Marilda Aparecida Milanez Morgado de
authors.initials: MA
authors.lastname: Abreu
authors.forename: Mayra Falcão
authors.initials: MF
authors.lastname: Pereira
authors.forename: Claúdia Cardoso Macedo de
authors.initials: CC
authors.lastname: Oliveira
authors.forename: Gisele Alborghetti
authors.initials: GA
authors.lastname: Nai
authors.forename: Deusita Fernandes Gandia
authors.initials: DF
authors.lastname: Soares
mesh_terms: D002115:Calciphylaxis / Q000175:diagnosis / Q000209:etiology* / Q000628:therapy; D005260:Female; D006801:Humans; D006962:Hyperparathyroidism, Secondary / Q000150:complications*; D007676:Kidney Failure, Chronic / Q000150:complications*; D008875:Middle Aged; D016896:Treatment Outcome