title: Role of fatty acids and polyphenols in inflammatory gene transcription and their impact on obesity, metabolic syndrome and diabetes.
abstract: Obesity, metabolic syndrome and diabetes represent multi-factorial conditions resulting from improper balances of hormones and gene expression. In addition, these conditions have a strong inflammatory component that can potentially be impacted by the diet. The purpose of this review is to discuss the molecular targets that can be addressed by anti-inflammatory nutrition. These molecular targets range from reduction of pro-inflammatory eicosanoids that can alter hormonal signaling cascades to the modulation of the innate immune system, via toll-like receptors and gene transcription factors. Working knowledge of the impact of nutrients, especially dietary fatty acids and polyphenols, on these various molecular targets makes it possible to develop a general outline of an anti-inflammatory diet that offers a unique, non-pharmacological approach for treating obesity, metabolic syndrome and diabetes.
authors.affiliation: Inflammation Research Foundation, Marblehead, MA, USA. bsears@drsears.com
authors.forename: B
authors.initials: B
authors.lastname: Sears
authors.forename: C
authors.initials: C
authors.lastname: Ricordi
mesh_terms: D017667:Adipocytes / Q000502:physiology; D016718:Arachidonic Acid / Q000096:biosynthesis; D003920:Diabetes Mellitus / Q000517:prevention & control*; D005227:Fatty Acids / Q000008:administration & dosage*; D006801:Humans; D007113:Immunity, Innate; D007249:Inflammation / Q000235:genetics / Q000517:prevention & control*; D024821:Metabolic Syndrome / Q000517:prevention & control*; D009765:Obesity / Q000517:prevention & control*; D059808:Polyphenols / Q000008:administration & dosage*; D014158:Transcription, Genetic
chemical_list: D005227:Fatty Acids; D059808:Polyphenols; D016718:Arachidonic Acid