title: Myeloid-derived suppressor cells (MDSCs) in gliomas and glioma-development.
abstract: Myeloid derived suppressor cells (MDSCs) are a heterogeneous population of cells that inhibit anti-tumor immunity through a variety of mechanisms. Malignant gliomas are heavily infiltrated by myeloid cells, some of which appear to share biological functions of MDSCs. Our data with mouse de novo gliomas indicate critical roles of these cells in glioma development. This review summarizes the current understanding of MDSC biology in gliomas and discusses therapeutic interventions that can safely reverse the suppressive effects of MDSCs. The insight gained from these findings may lead to the development of novel immunotherapeutic strategies for gliomas.
authors.affiliation: Department of Infectious Diseases and Microbiology, University of Pittsburgh Graduate School of Public Health, Pittsburgh, PA 15261, USA.
authors.forename: Gary
authors.initials: G
authors.lastname: Kohanbash
authors.forename: Hideho
authors.initials: H
authors.lastname: Okada
mesh_terms: D000818:Animals; D000911:Antibodies, Monoclonal / Q000494:pharmacology / Q000627:therapeutic use; D001119:Arginase / Q000235:genetics / Q000276:immunology; D039481:CD11b Antigen / Q000235:genetics / Q000276:immunology; D051546:Cyclooxygenase 2 / Q000235:genetics / Q000276:immunology; D004791:Enzyme Inhibitors / Q000494:pharmacology / Q000627:therapeutic use; D005910:Glioma / Q000276:immunology / Q000378:metabolism / Q000473:pathology* / Q000628:therapy*; D006801:Humans; D007108:Immune Tolerance; D007167:Immunotherapy; D053662:Interleukin-4 Receptor alpha Subunit / Q000235:genetics / Q000276:immunology; D051379:Mice; D023461:Myeloid Progenitor Cells / Q000187:drug effects* / Q000276:immunology / Q000473:pathology; D013601:T-Lymphocytes / Q000187:drug effects* / Q000276:immunology / Q000473:pathology; D019139:Tumor Escape
chemical_list: D000911:Antibodies, Monoclonal; D039481:CD11b Antigen; D004791:Enzyme Inhibitors; C504000:IL4R protein, human; C509295:ITGAM protein, human; D053662:Interleukin-4 Receptor alpha Subunit; D051546:Cyclooxygenase 2; C496540:PTGS2 protein, human; C574619:ARG1 protein, human; D001119:Arginase