title: Total synthesis of (-)-tirandamycin C utilizing a desymmetrization protocol.
abstract: A highly stereoselective total synthesis of (-)-tirandamycin C has been achieved following a desymmetrization protocol developed in our group, Horner-Wadsworth-Emmons olefination, acid-catalyzed ketalization, Still-Gennari (Z)-selective olefination, and Dieckmann cyclization as key reactions.
authors.affiliation: Natural Products Chemistry Division, CSIR-Indian Institute of Chemical Technology, Hyderabad 500 007, India. yadavpub@iict.res.in
authors.forename: J S
authors.initials: JS
authors.lastname: Yadav
authors.forename: Santu
authors.initials: S
authors.lastname: Dhara
authors.forename: Sk Samad
authors.initials: SS
authors.lastname: Hossain
authors.forename: Debendra K
authors.initials: DK
authors.lastname: Mohapatra
mesh_terms: D000475:Alkenes / Q000737:chemistry*; D000617:Aminoglycosides / Q000138:chemical synthesis* / Q000737:chemistry; D002384:Catalysis; D003500:Cyclization; D015394:Molecular Structure; D013237:Stereoisomerism
chemical_list: D000475:Alkenes; D000617:Aminoglycosides; C545292:tirandamycin C