title: Huge malignant melanoma of caruncle with extensive involvement of conjunctiva.
abstract: The caruncle is nodular structure lying at internal canthus medial to plica semilunaris. It is composed of elements of conjunctiva, cutaneous and lacrimal tissue. In spite of its diverse histopathology, lesions of caruncle are rare and malignant melanoma is further rarer. This tumour is potentially lethal, even after prompt and proper treatment, especially after delayed onset of therapy. Clinical metastases usually occur first to the lymph nodes in approximately 45% to 60% of patients with regional metastases. Eventually systemic dissemination may occur to lung, brain, liver, skin, bone and the gastrointestinal tract, although this often arises without prior clinical evidence of regional lymph node involvement. Here a rare case of huge malignant melanoma of caruncle with extensive involvement of plica semilunaris, fornix and palpebral conjuctiva in a 58-years old male is reported who was treated with local excision combined with cryotherapy and topical 0.02% mitomycin-C eye drops.
authors.affiliation: Department of Ophthalmology, SS Medical College, Rewa 486001.
authors.forename: Shashi
authors.initials: S
authors.lastname: Jain
authors.forename: Shivcharan L
authors.initials: SL
authors.lastname: Chandravanshi
authors.forename: M K
authors.initials: MK
authors.lastname: Rathore
authors.forename: Pranu
authors.initials: P
authors.lastname: Goyal
authors.forename: S C
authors.initials: SC
authors.lastname: Jain
mesh_terms: D000903:Antibiotics, Antineoplastic / Q000008:administration & dosage; D003131:Combined Modality Therapy; D003230:Conjunctival Neoplasms / Q000473:pathology* / Q000601:surgery; D017679:Cryotherapy; D006801:Humans; D008297:Male; D008545:Melanoma / Q000473:pathology* / Q000601:surgery; D008875:Middle Aged; D016685:Mitomycin / Q000008:administration & dosage
chemical_list: D000903:Antibiotics, Antineoplastic; D016685:Mitomycin