title: Genome sequences of three live attenuated vaccine strains of Brucella species and implications for pathogenesis and differential diagnosis.
abstract: Live attenuated vaccines play essential roles in the prevention of brucellosis. Here, we report the draft genome sequences of three vaccine strains, Brucella melitensis M5-10, B. suis S2-30, and B. abortus 104M. Primary genome sequence analysis identified mutations, deletions, and insertions which have implications for attenuation and signatures for differential diagnosis.
authors.affiliation: Department of Infectious Disease Control, Beijing Institute of Disease Control and Prevention, Beijing, People's Republic of China.
authors.forename: Yufei
authors.initials: Y
authors.lastname: Wang
authors.forename: Yuehua
authors.initials: Y
authors.lastname: Ke
authors.forename: Zhoujia
authors.initials: Z
authors.lastname: Wang
authors.forename: Xitong
authors.initials: X
authors.lastname: Yuan
authors.forename: Yefeng
authors.initials: Y
authors.lastname: Qiu
authors.forename: Qing
authors.initials: Q
authors.lastname: Zhen
authors.forename: Jie
authors.initials: J
authors.lastname: Xu
authors.forename: Tiefeng
authors.initials: T
authors.lastname: Li
authors.forename: Dali
authors.initials: D
authors.lastname: Wang
authors.forename: Liuyu
authors.initials: L
authors.lastname: Huang
authors.forename: Zeliang
authors.initials: Z
authors.lastname: Chen
mesh_terms: D002004:Brucella Vaccine / Q000235:genetics; D002003:Brucella abortus / Q000145:classification / Q000235:genetics* / Q000472:pathogenicity; D017347:Brucella melitensis / Q000145:classification / Q000235:genetics* / Q000472:pathogenicity; D041021:Brucella suis / Q000145:classification / Q000235:genetics* / Q000472:pathogenicity; D002006:Brucellosis / Q000175:diagnosis / Q000382:microbiology; D004269:DNA, Bacterial / Q000737:chemistry* / Q000235:genetics*; D003937:Diagnosis, Differential; D016680:Genome, Bacterial; D008969:Molecular Sequence Data; D011110:Polymorphism, Genetic; D017422:Sequence Analysis, DNA; D014613:Vaccines, Attenuated / Q000235:genetics
chemical_list: D002004:Brucella Vaccine; D004269:DNA, Bacterial; D014613:Vaccines, Attenuated