title: Soluble fms-like tyrosine kinase-1 (sFLT-1) predicts post-percutaneous coronary intervention (PCI) myocardial infarction (MI type 4a).
abstract: BACKGROUND
  Acute myocardial infarction (AMI) related to percutaneous coronary intervention (PCI) (MI type 4a) occurs in up to 26% of elective patients.
  
  
  OBJECTIVE
  To evaluate if sFLT-1 helps to predict MI type 4a in troponin negative patients with elective PCI.
  
  
  METHODS
  We enrolled 135 patients, 106 had a PCI. sFLT-1 levels were assessed at five time points before and after PCI.
  
  
  RESULTS
  MI type 4a occurred in 22.1% of patients. sFLT-1 levels at admission above 251 pg/mL indicated a significant relative risk for MI type 4a of 2.83.
  
  
  CONCLUSIONS
  Increased sFLT-1 levels at baseline might indicate unstable atherosclerosis and risk for microembolization and thus be predictive of MI type 4a.
authors.affiliation: Department of Cardiology CVK and Emergency Medicine CVK and CCM, Charité Universitätsmedizin Berlin, Berlin, Germany.
authors.forename: Julia
authors.initials: J
authors.lastname: Searle
authors.forename: Anna
authors.initials: A
authors.lastname: Slagman
authors.forename: Stefanie
authors.initials: S
authors.lastname: Gwosc
authors.forename: Jörn Ole
authors.initials: JO
authors.lastname: Vollert
authors.forename: Fabian
authors.initials: F
authors.lastname: Holert
authors.forename: Christian
authors.initials: C
authors.lastname: Müller
authors.forename: Reinhold
authors.initials: R
authors.lastname: Muller
authors.forename: Martin
authors.initials: M
authors.lastname: Möckel
mesh_terms: D000368:Aged; D015415:Biomarkers / Q000097:blood*; D016009:Chi-Square Distribution; D005260:Female; D006801:Humans; D007118:Immunoassay; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000097:blood / Q000175:diagnosis / Q000601:surgery*; D017063:Outcome Assessment, Health Care; D062645:Percutaneous Coronary Intervention / Q000379:methods*; D011237:Predictive Value of Tests; D011379:Prognosis; D012044:Regression Analysis; D013997:Time Factors; D040281:Vascular Endothelial Growth Factor Receptor-1 / Q000097:blood*
chemical_list: D015415:Biomarkers; C501162:FLT1 protein, human; D040281:Vascular Endothelial Growth Factor Receptor-1