title: Duloxetine versus citalopram and sertraline in the treatment of poststroke depression, anxiety, and fatigue.
abstract: The authors sought to determine the relative efficacy and tolerability of duloxetine versus citalopram and sertraline in the treatment of poststroke depression (PSD), anxiety, and fatigue. A group of 60 patients with PSD were assigned to receive duloxetine, citalopram, or sertraline and were assessed over a 3-month period for depression, anxiety, and fatigue. Improvement of depression and anxiety, but not fatigue, was observed in all study groups. Duloxetine was well tolerated and significantly more effective than citalopram and sertraline for the treatment of anxiety symptoms in PSD patients. None of the antidepressants used was effective for reducing symptoms of fatigue.
authors.affiliation: Department of Psychiatry, Athens University Medical School, Eginition Hospital, Athens, Greece. Karaiskos@gmail.com
authors.forename: Dimitrios
authors.initials: D
authors.lastname: Karaiskos
authors.forename: Elias
authors.initials: E
authors.lastname: Tzavellas
authors.forename: Konstantinos
authors.initials: K
authors.lastname: Spengos
authors.forename: Sofia
authors.initials: S
authors.lastname: Vassilopoulou
authors.forename: Thomas
authors.initials: T
authors.lastname: Paparrigopoulos
mesh_terms: D000203:Activities of Daily Living; D000328:Adult; D000368:Aged; D000928:Antidepressive Agents / Q000627:therapeutic use*; D001007:Anxiety / Q000188:drug therapy* / Q000209:etiology; D015283:Citalopram / Q000627:therapeutic use; D003863:Depression / Q000188:drug therapy* / Q000209:etiology; D000068736:Duloxetine Hydrochloride; D005221:Fatigue / Q000188:drug therapy* / Q000209:etiology; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D020280:Sertraline / Q000627:therapeutic use; D020521:Stroke / Q000150:complications; D013876:Thiophenes / Q000627:therapeutic use; D013997:Time Factors; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D000928:Antidepressive Agents; D013876:Thiophenes; D015283:Citalopram; D000068736:Duloxetine Hydrochloride; D020280:Sertraline