title: Robust helix formation in a new family of oligoureas based on a constrained bicyclic building block.
abstract: BAC for more: a constrained bicyclic building block with urea linkages is an efficient combination for the formation of a highly rigid helical system. This type of bicyclic amino carbamoyl (BAC) foldamer was studied both in solution and in the solid state. A robust H-bond (dotted line) network was found between the carbonyl oxygen atoms (red) and the amino groups (dark blue) within the helix.
authors.affiliation: Laboratoire de Chimie-Physique Macromoléculaire, LCPM-UMR CNRS Université de Lorraine, Nancy, France.
authors.forename: Baptiste
authors.initials: B
authors.lastname: Legrand
authors.forename: Christophe
authors.initials: C
authors.lastname: André
authors.forename: Emmanuel
authors.initials: E
authors.lastname: Wenger
authors.forename: Claude
authors.initials: C
authors.lastname: Didierjean
authors.forename: Marie Christine
authors.initials: MC
authors.lastname: Averlant-Petit
authors.forename: Jean
authors.initials: J
authors.lastname: Martinez
authors.forename: Monique
authors.initials: M
authors.lastname: Calmes
authors.forename: Muriel
authors.initials: M
authors.lastname: Amblard
mesh_terms: D001643:Bridged Bicyclo Compounds / Q000737:chemistry; D002942:Circular Dichroism; D008958:Models, Molecular; D008968:Molecular Conformation; D019906:Nuclear Magnetic Resonance, Biomolecular; D009795:Octanes / Q000737:chemistry; D017433:Protein Structure, Secondary; D014508:Urea / Q000031:analogs & derivatives / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D001643:Bridged Bicyclo Compounds; D009795:Octanes; D014508:Urea