title: 5-HT(3) receptors.
abstract: 5-Hydroxytryptamine type 3 (5-HT(3)) receptors are cation-selective Cys loop receptors found in both the central and peripheral nervous systems. There are five 5-HT(3) receptor subunits (A-E), and all functional receptors require at least one A subunit. Regions from noncontiguous parts of the subunit sequence contribute to the agonist-binding site, and the roles of a range of amino acid residues that form the binding pocket have been identified. Drugs that selectively antagonize 5-HT(3) receptors (the "setrons") are the current gold standard for treatment of chemotherapy-induced and postoperative nausea and vomiting and have potential for the treatment of a range of other conditions.
authors.affiliation: Department of Biochemistry, University of Cambridge, Cambridge CB2 1QW, UK. sl120@cam.ac.uk
authors.forename: Sarah C R
authors.initials: SC
authors.lastname: Lummis
mesh_terms: D000818:Animals; D001665:Binding Sites; D006801:Humans; D044406:Receptors, Serotonin, 5-HT3 / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D058827:Serotonin 5-HT3 Receptor Agonists / Q000378:metabolism; D058831:Serotonin 5-HT3 Receptor Antagonists / Q000378:metabolism
chemical_list: D044406:Receptors, Serotonin, 5-HT3; D058827:Serotonin 5-HT3 Receptor Agonists; D058831:Serotonin 5-HT3 Receptor Antagonists