title: Facilitating pharmacometric workflow with the metrumrg package for R.
abstract: metrumrg is an R package that facilitates workflow for the discipline of pharmacometrics. Support is provided for data preparation, modeling, simulation, diagnostics, and reporting. Existing tools and techniques are emphasized where available; original solutions are provided for otherwise unmet needs. In particular, metrumrg implements an R interface for the NONMEM(®) modeling software, optionally run in a distributed computing environment. The paradigm allows start-to-finish analyses in a single scripting language. Emphasis on text-based formats promotes traceability of results.
authors.affiliation: Metrum Institute, Tariffville, CT, USA. timb@metrumrg.com
authors.forename: Timothy T
authors.initials: TT
authors.lastname: Bergsma
authors.forename: William
authors.initials: W
authors.lastname: Knebel
authors.forename: Jeannine
authors.initials: J
authors.lastname: Fisher
authors.forename: William R
authors.initials: WR
authors.lastname: Gillespie
authors.forename: Matthew M
authors.initials: MM
authors.lastname: Riggs
authors.forename: Leonid
authors.initials: L
authors.lastname: Gibiansky
authors.forename: Marc R
authors.initials: MR
authors.lastname: Gastonguay
mesh_terms: D006801:Humans; D008954:Models, Biological; D000069437:Pharmacological Phenomena; D012984:Software; D057188:Workflow