title: C-dideoxyhexosyl flavones from the stems and leaves of Passiflora edulis Sims.
abstract: The stems and leaves of Passiflora edulis Sims, are used as a folk medicine for treating both anxiety and nervousness in American countries. Phytochemical investigation of the n-butanol (n-BuOH) fraction of this plant led to the isolation of four new 2,6-dideoxyhexose-C-glycosyl flavones, including luteolin-8-C-β-digitoxopyranosyl-4'-O-β-d-glucopyranoside (1), apigenin-8-C-β-digitoxopyranoside (2), apigenin-8-C-β-boivinopyranoside (3) and luteolin-8-C-β-boivinopyranoside (4), together with five known compounds (5-9). The structures of these compounds were elucidated by extensive spectroscopic methods. All compounds were evaluated for their neurite outgrowth enhancing activities and the results indicated that luteolin (7) enhanced NGF-induced neurite outgrowth in PC12 cells at 50.0μM.
authors.affiliation: Kunming Institute of Botany, Chinese Academy of Sciences, Kunming , People's Republic of China.
authors.forename: Fengqing
authors.initials: F
authors.lastname: Xu
authors.forename: Cong
authors.initials: C
authors.lastname: Wang
authors.forename: Liping
authors.initials: L
authors.lastname: Yang
authors.forename: Huairong
authors.initials: H
authors.lastname: Luo
authors.forename: Weiwei
authors.initials: W
authors.lastname: Fan
authors.forename: Chengting
authors.initials: C
authors.lastname: Zi
authors.forename: Fawu
authors.initials: F
authors.lastname: Dong
authors.forename: Jiangmiao
authors.initials: J
authors.lastname: Hu
authors.forename: Jun
authors.initials: J
authors.lastname: Zhou
mesh_terms: D000818:Animals; D049109:Cell Proliferation / Q000187:drug effects; D047309:Flavones / Q000737:chemistry / Q000302:isolation & purification*; D015394:Molecular Structure; D009474:Neurons / Q000166:cytology / Q000187:drug effects; D016716:PC12 Cells; D029598:Passiflora / Q000737:chemistry*; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification; D018515:Plant Leaves / Q000737:chemistry*; D018547:Plant Stems / Q000737:chemistry*; D051381:Rats
chemical_list: D047309:Flavones; D010936:Plant Extracts