title: [Prenatal diagnosis of cleft lip with or without cleft palate: retrospective study and review].
abstract: OBJECTIVE
  To evaluate the management of prenatally diagnosed cleft lip with or without cleft palate and the immediate postnatal outcome.
  
  
  METHODS
  Retrospective study of all cases of cleft lip with or without cleft palate referred to our fetal medicine unit, between January 2005 and January 2011. The anatomical type of cleft, associated malformations, and the postnatal outcome were reviewed.
  
  
  RESULTS
  Forty-three cases of fetal cleft lip with or without cleft palate were reviewed. The mean gestational age at diagnosis was 24 weeks ± 4. The postnatal distribution of clefts was: 30 cleft lip and palate (70%) and 13 cleft lip (30%). The prenatal diagnosis of the cleft type was exact in 27 cases (62.8%). Nine cases had associated anomalies (21%), detected prenatally in three cases (37.5%). There was no karyotypical abnormality. Six pregnancies were terminated (14%). The immediate postnatal outcome was comparable with unselected newborns.
  
  
  CONCLUSIONS
  The prenatal diagnosis of cleft lip with or without cleft palate is correct, with two thirds of exact diagnoses. Large clefts palate are the best detected. Associated malformations cannot always be diagnosed by prenatal ultrasound, but have to be searched for because they modify the fetal outcome.
authors.affiliation: Service de gynécologie-obstétrique, centre pluridisciplinaire de diagnostic prénatal de l'Est Parisien, hôpital Armand-Trousseau, AP-HP, Paris-6, 26, avenue Arnold-Netter, 75012 Paris, France. anne.maria.guyot@gmail.com
authors.forename: A
authors.initials: A
authors.lastname: Guyot
authors.forename: V
authors.initials: V
authors.lastname: Soupre
authors.forename: M-P
authors.initials: MP
authors.lastname: Vazquez
authors.forename: A
authors.initials: A
authors.lastname: Picard
authors.forename: J
authors.initials: J
authors.lastname: Rosenblatt
authors.forename: C
authors.initials: C
authors.lastname: Garel
authors.forename: M
authors.initials: M
authors.lastname: Gonzales
authors.forename: S
authors.initials: S
authors.lastname: Marlin
authors.forename: J-L
authors.initials: JL
authors.lastname: Benifla
authors.forename: J-M
authors.initials: JM
authors.lastname: Jouannic
mesh_terms: D002971:Cleft Lip / Q000150:complications / Q000175:diagnosis* / Q000196:embryology; D002972:Cleft Palate / Q000150:complications / Q000175:diagnosis* / Q000196:embryology; D005260:Female; D005865:Gestational Age; D006801:Humans; D007231:Infant, Newborn; D007621:Karyotyping; D011247:Pregnancy; D011296:Prenatal Diagnosis; D012189:Retrospective Studies; D016216:Ultrasonography, Prenatal