title: External beam radiotherapy versus brachytherapy in the management of malignant oesophageal dysphagia: a retrospective study.
abstract: OBJECTIVE
  Dysphagia is a prominent symptom of oesophageal cancer which may be palliated by stent, external beam radiation (EBRT) or intraluminal brachytherapy (ILBT). Brachytherapy is not widely practised in the UK. The aim of this study was to compare the efficacy of ILBT and EBRT in relieving malignant dysphagia.
  
  
  METHODS
  The radiotherapy database at Northampton Cancer Centre (NCC) was used to identify patients who underwent ILBT or EBRT for malignant dysphagia between 1.1.2008 and 31.3 2010. Data was collected on patient demographics, tumour characteristics, treatment received and dysphagia score pre- and post- treatment. Serial assessment of dysphagia was used to determine the duration of symptomatic improvement. EBRT involved 20-30 Gy in 5-10 fractions. Brachytherapy applicator placement was done by an experienced endoscopist at the high dose rate (HDR) suite and a single treatment dose of 12 Gy was prescribed at 1 cm depth. Oesophageal dilation was performed prior to brachytherapy treatment if needed.
  
  
  RESULTS
  44 patients were included in this study (EBRT: 21; ILBT: 23). Patient characteristics were well balanced between the two groups. The average dysphagia scores in the EBRT group prior to treatment were 3, and at 4, 8 and 16 weeks following treatment they were 3.4, 2.4, 2.1 and 2.1, respectively. The corresponding dysphagia scores in the ILBT group were 3.5 before treatment and 2.2, 2.1 and 2.3 following treatment, respectively. There was significant improvement in dysphagia in both groups at 4 weeks (p<0.0001), and the benefit was sustained after 8 and 16 weeks. No major complications were reported from either EBRT or oesophageal brachytherapy.
  
  
  CONCLUSIONS
  ILBT is an effective alternative to multifractionated EBRT for palliation of malignant dysphagia providing a convenient one-stop treatment for patients who live a long distance from their cancer centre. Our model of performing the endoscopically guided procedure in the brachytherapy unit is comparable in cost to fractionated EBRT and can be adopted by other centres.
authors.affiliation: Department of Clinical Oncology, Northampton General Hospital, Northampton, UK. hheldeeb@yahoo.com
authors.forename: H
authors.initials: H
authors.lastname: Eldeeb
authors.forename: S
authors.initials: S
authors.lastname: Reza
authors.forename: U
authors.initials: U
authors.lastname: Shmueli
authors.forename: G
authors.initials: G
authors.lastname: Logsdail
authors.forename: P
authors.initials: P
authors.lastname: Hinks
authors.forename: S
authors.initials: S
authors.lastname: Mukherjee
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001918:Brachytherapy; D003680:Deglutition Disorders / Q000401:mortality / Q000532:radiotherapy*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies