title: [Association study between age-related macular degeneration and R1210C mutation of CFH gene in Chinese population].
abstract: OBJECTIVE
  A R1210C mutation of complement factor H (CFH) gene has been associated with age-related macular degeneration (AMD) in Caucasian population. This study was to verify above association in Han Chinese population.
  
  
  METHODS
  The mutation was detected by direct sequencing in 258 patients with wet AMD and 426 matched controls.
  
  
  RESULTS
  The R1210C mutation has not been identified in either sample.
  
  
  CONCLUSIONS
  The R1210C mutation in CFH gene is not associated with AMD in Han Chinese population.
authors.affiliation: West China School of Medicine, Sichuan University, Chengdu, Sichuan, People's Republic of China.
authors.forename: Si-kui
authors.initials: SK
authors.lastname: Shen
authors.forename: Xiao-qi
authors.initials: XQ
authors.lastname: Liu
authors.forename: Fang
authors.initials: F
authors.lastname: Lu
authors.forename: Zheng-lin
authors.initials: ZL
authors.lastname: Yang
authors.forename: Yi
authors.initials: Y
authors.lastname: Shi
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D017242:Complement Factor H / Q000235:genetics*; D005260:Female; D006801:Humans; D008268:Macular Degeneration / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D009154:Mutation
chemical_list: D017242:Complement Factor H