title: PPAR-ϒ pathway to vascular dysfunction.
abstract: Humans with dominant-negative (DN) mutations in PPAR-ϒ develop early onset hypertension. A recent study by Pelham et al. (2012) shows that loss of PPAR-ϒ repression of the Rho kinase pathway leads to altered vascular function via a smooth-muscle-dependent pathway that is independent of NO and oxidant stress.
authors.affiliation: Department of Physiology, Medical College of Wisconsin, Milwaukee, WI 53226, USA.
authors.forename: Julian H
authors.initials: JH
authors.lastname: Lombard
authors.forename: Allen W
authors.initials: AW
authors.lastname: Cowley