title: Solving the mystery of procollagen chain selectivity.
abstract: The recently solved crystal structure of the procollagen C propeptide reveals the basis for chain selectivity as well as an unexpected asymmetry to this homotrimeric molecule. In addition, mapping disease-causing mutations to the structure demonstrates clear correlation between severity of disease and mutation location.
authors.affiliation: Institute of Cellular, Molecular and Systems Biology, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, UK. neil.bulleid@glasgow.ac.uk
authors.forename: Neil J
authors.initials: NJ
authors.lastname: Bulleid
mesh_terms: D003095:Collagen Diseases / Q000235:genetics*; D024061:Collagen Type III / Q000737:chemistry* / Q000378:metabolism*; D006801:Humans
chemical_list: D024061:Collagen Type III