title: α-1 antitrysin DAMPens GVHD.
abstract: In this issue of Blood, Brennan et al report that a noninfectious damage-associated molecular pattern (DAMP), heparan sulfate (HS),(1) aggravates graft-versus-host disease (GVHD) and that this enhanced severity can be dampened by administration of serine protease inhibitor α-1 antitrysin (AAT).(2)
authors.affiliation: University of Michigan Comprehensive Cancer Center, MI, USA.
authors.forename: Pavan
authors.initials: P
authors.lastname: Reddy
mesh_terms: D000818:Animals; D005260:Female; D006086:Graft vs Host Disease / Q000209:etiology*; D019337:Hematologic Neoplasms / Q000150:complications*; D006497:Heparan Sulfate / Q000009:adverse effects*; D006801:Humans; D008297:Male; D033581:Stem Cell Transplantation / Q000009:adverse effects*; D013601:T-Lymphocytes / Q000187:drug effects*; D051197:Toll-Like Receptor 4 / Q000819:agonists*
chemical_list: D006497:Heparan Sulfate; D051197:Toll-Like Receptor 4