title: Nanocoating of titanium implant surfaces with organic molecules. Polysaccharides including glycosaminoglycans.
abstract: Long-term stability of titanium implants are dependent on a variety of factors. Nanocoating with organic molecules is one of the method used to improve osseointegration. Nanoscale modification of titanium implants affects surface properties, such as hydrophilicity, biochemical bonding capacity and roughness. This influences cell behaviour on the surface such as adhesion, proliferation and differentiation of cells as well as the mineralization of the extracellular matrix at the implant surfaces. The aim of the present systematic review was to describe organic molecules used for surface nanocoating with focus on polysaccharides including glycosaminoglycans, and how these molecules change surface properties, cell reactions and affect on osseointegartion. The included in vitro studies demonstrated increased cell adhesion, proliferation and mineralization of a number of the tested polysaccharide nanocoatings. The included in vivo studies, showed improvement of bone interface reactions measured as increased Bone-to-Implant Contact length and Bone Mineral Density adjacent to the polysaccharide coated surfaces. Based on existing literature, surface modification with polysaccharide and glycosaminoglycans appears to be an effective way to stimulate bone regeneration on bone-implant interface.
authors.affiliation: Research Center for Ageing and Osteoporosis, Department of Medicine and Clinical Biochemistry, Glostrup University Hospital, Ndr Ringvej 69, 2600 Glostrup, Denmark.
authors.forename: Katarzyna
authors.initials: K
authors.lastname: Gurzawska
authors.forename: Rikke
authors.initials: R
authors.lastname: Svava
authors.forename: Niklas Rye
authors.initials: NR
authors.lastname: Jørgensen
authors.forename: Klaus
authors.initials: K
authors.lastname: Gotfredsen
mesh_terms: D000818:Animals; D020099:Coated Materials, Biocompatible / Q000378:metabolism*; D003094:Collagen / Q000737:chemistry; D004867:Equipment Design; D006025:Glycosaminoglycans / Q000737:chemistry*; D006801:Humans; D049329:Nanostructures / Q000737:chemistry*; D016348:Osseointegration; D011134:Polysaccharides / Q000737:chemistry*; D019736:Prostheses and Implants; D013499:Surface Properties; D014025:Titanium / Q000737:chemistry*
chemical_list: D020099:Coated Materials, Biocompatible; D006025:Glycosaminoglycans; D011134:Polysaccharides; D003094:Collagen; D014025:Titanium