title: First total synthesis of prasinic acid and its anticancer activity.
abstract: The first total synthesis of prasinic acid is being reported along with its biological evaluation. The ten step synthesis involved readily available and cheap starting materials and can easily be transposed to large scale manufacturing. The crucial steps of the synthesis included the formation of two different aromatic units (7 and 9) and their coupling reaction. The synthetic prasinic acid exhibited moderate antitumor activity (IC(50) 4.3-9.1 μM) in different lines of cancer cells.
authors.affiliation: Department of natural products chemistry, Piramal Healthcare Limited, 1 Nirlon Complex, Goregaon (E), Mumbai 400 063, India.
authors.forename: Narayan
authors.initials: N
authors.lastname: Chakor
authors.forename: Ganesh
authors.initials: G
authors.lastname: Patil
authors.forename: Diana
authors.initials: D
authors.lastname: Writer
authors.forename: Giridharan
authors.initials: G
authors.lastname: Periyasamy
authors.forename: Rajiv
authors.initials: R
authors.lastname: Sharma
authors.forename: Abhijit
authors.initials: A
authors.lastname: Roychowdhury
authors.forename: Prabhu Dutt
authors.initials: PD
authors.lastname: Mishra
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D001565:Benzoates / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D004354:Drug Screening Assays, Antitumor; D006536:Heptanes / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D006801:Humans; D020128:Inhibitory Concentration 50; D015394:Molecular Structure
chemical_list: D000970:Antineoplastic Agents; D001565:Benzoates; D006536:Heptanes; C578922:prasinic acid