title: Clinical outcomes of 1,578 Chinese patients with breast benign diseases after ultrasound-guided vacuum-assisted excision: recurrence and the risk factors.
abstract: BACKGROUND
  The aim of this study was to evaluate the clinical outcomes of 1,578 patients with breast benign diseases after excisions and the risk factors.
  
  
  RESULTS
  With a median follow-up of 34 months, 69 patients were identified to have recurrence (local recurrence: 45; new lesion: 24). Univariate and multivariate analyses revealed that multiple lesions, a larger lesion size, and a hematoma were independent risk factors for recurrence. Patients with in situ recurrence tended to have fewer lesions and more samples taken per lesion. Patients with new lesions tended to have multiple lesions. After re-excisions, there was no second recurrence events observed in the patients with local recurrence (0/30), whereas 5 patients with new lesions (5/14) were noted to have second recurrence events.
  
  
  CONCLUSIONS
  Ultrasound-guided vacuum-assisted biopsy for the complete excision of breast benign diseases is safe and effective. Local recurrence and new lesions may have different clinicopathological features and underlying mechanisms. Different management might be given to patients with a different pattern of recurrence.
authors.affiliation: Department of Breast Surgery, Breast Tumor Center, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou 510120, China.
authors.forename: Shunrong
authors.initials: S
authors.lastname: Li
authors.forename: Jiannan
authors.initials: J
authors.lastname: Wu
authors.forename: Kai
authors.initials: K
authors.lastname: Chen
authors.forename: Weijuan
authors.initials: W
authors.lastname: Jia
authors.forename: Liang
authors.initials: L
authors.lastname: Jin
authors.forename: Qiaozhen
authors.initials: Q
authors.lastname: Xiao
authors.forename: Yunjie
authors.initials: Y
authors.lastname: Zeng
authors.forename: Fengxi
authors.initials: F
authors.lastname: Su
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001707:Biopsy, Needle / Q000295:instrumentation*; D001941:Breast Diseases / Q000473:pathology / Q000628:therapy*; D002648:Child; D002681:China; D004438:Ecchymosis / Q000453:epidemiology; D005260:Female; D005500:Follow-Up Studies; D006406:Hematoma / Q000453:epidemiology; D006801:Humans; D008875:Middle Aged; D015999:Multivariate Analysis; D010146:Pain / Q000453:epidemiology; D010147:Pain Measurement; D012008:Recurrence; D012189:Retrospective Studies; D012307:Risk Factors; D018084:Ultrasonography, Interventional; D014618:Vacuum; D055815:Young Adult