title: Nanolesions induced by heavy ions in human tissues: Experimental and theoretical studies.
abstract: The biological effects of energetic heavy ions are attracting increasing interest for their applications in cancer therapy and protection against space radiation. The cascade of events leading to cell death or late effects starts from stochastic energy deposition on the nanometer scale and the corresponding lesions in biological molecules, primarily DNA. We have developed experimental techniques to visualize DNA nanolesions induced by heavy ions. Nanolesions appear in cells as "streaks" which can be visualized by using different DNA repair markers. We have studied the kinetics of repair of these "streaks" also with respect to the chromatin conformation. Initial steps in the modeling of the energy deposition patterns at the micrometer and nanometer scale were made with MCHIT and TRAX models, respectively.
authors.affiliation: Frankfurt Institute for Advanced Studies (FIAS), Ruth-Moufang-Str. 1, 60438 Frankfurt am Main, Germany ; Institut für Theoretische Physik, Johann Wolfgang Goethe-Universität, Max-von-Laue-Str. 1, 60438 Frankfurt am Main, Germany.
authors.forename: Marcus
authors.initials: M
authors.lastname: Bleicher
authors.forename: Lucas
authors.initials: L
authors.lastname: Burigo
authors.forename: Marco
authors.initials: M
authors.lastname: Durante
authors.forename: Maren
authors.initials: M
authors.lastname: Herrlitz
authors.forename: Michael
authors.initials: M
authors.lastname: Krämer
authors.forename: Igor
authors.initials: I
authors.lastname: Mishustin
authors.forename: Iris
authors.initials: I
authors.lastname: Müller
authors.forename: Francesco
authors.initials: F
authors.lastname: Natale
authors.forename: Igor
authors.initials: I
authors.lastname: Pshenichnov
authors.forename: Stefan
authors.initials: S
authors.lastname: Schramm
authors.forename: Gisela
authors.initials: G
authors.lastname: Taucher-Scholz
authors.forename: Cathrin
authors.initials: C
authors.lastname: Wälzlein