title: Clinical impact of switching conventional enzyme immunoassay with nucleic acid amplification test for suspected Clostridium difficile-associated diarrhea.
abstract: The impact of a new Clostridium difficile nucleic acid amplification test (NAAT) on antibiotic utilization in patients with suspected C difficile infection was assessed. This single-center, cross-sectional study of 270 patients demonstrated that the use of NAAT decreased antibiotic expenditure by reducing prolonged empiric days of therapy in these patients.
authors.affiliation: Department of Pharmacy Practice, Campbell University College of Pharmacy and Health Sciences, Buies Creek, NC, USA. steven.johnson@duke.edu
authors.forename: Steven W
authors.initials: SW
authors.lastname: Johnson
authors.forename: Meganne
authors.initials: M
authors.lastname: Kanatani
authors.forename: Romney M
authors.initials: RM
authors.lastname: Humphries
authors.forename: Daniel Z
authors.initials: DZ
authors.lastname: Uslan
mesh_terms: D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D019411:Clinical Laboratory Techniques / Q000379:methods*; D016360:Clostridioides difficile / Q000235:genetics / Q000276:immunology / Q000302:isolation & purification*; D003015:Clostridium Infections / Q000175:diagnosis* / Q000382:microbiology; D003430:Cross-Sectional Studies; D003967:Diarrhea / Q000175:diagnosis* / Q000382:microbiology; D004363:Drug Utilization / Q000706:statistics & numerical data; D005260:Female; D006801:Humans; D007124:Immunoenzyme Techniques / Q000379:methods*; D008297:Male; D008875:Middle Aged; D021141:Nucleic Acid Amplification Techniques / Q000379:methods*
chemical_list: D000900:Anti-Bacterial Agents