title: Cocaine-levamisole thrombotic vasculopathy.
abstract: The syndrome of cocaine-levamisole thrombotic vasculopathy is a tetrad of cutaneous manifestations, arthralgia, leukopenia, and positive antineutrophil cytoplasmic antigen (ANCA). Cocaine is cut with levamisole to potentiate its euphoric effects. However, along with this are the adverse reactions of levamisole such as fatal agranulocytosis, flu-like symptoms, and cutaneous thrombotic vasculopathy. High index of suspicion is needed for its diagnosis. This article will review on its toxicities, especially its prothrombotic effects.
authors.affiliation: Department of Hematology and Oncology, St. Luke's Roosevelt Hospital Center, New York, New York 10019, USA. irenedymd@yahoo.com
authors.forename: Irene A
authors.initials: IA
authors.lastname: Dy
authors.forename: Peter H
authors.initials: PH
authors.lastname: Wiernik
mesh_terms: D003042:Cocaine / Q000009:adverse effects*; D019970:Cocaine-Related Disorders / Q000209:etiology / Q000473:pathology; D006801:Humans; D007978:Levamisole / Q000009:adverse effects*; D017445:Skin Diseases, Vascular / Q000139:chemically induced* / Q000473:pathology; D013927:Thrombosis / Q000139:chemically induced* / Q000473:pathology
chemical_list: D007978:Levamisole; D003042:Cocaine