title: Effects of pharmacological agents, sleep deprivation, hypoxia and transcranial magnetic stimulation on electroencephalographic rhythms in rodents: towards translational challenge models for drug discovery in Alzheimer's disease.
abstract: Different kinds of challenge can alter spontaneous ongoing electroencephalographic (EEG) rhythms in animal models, thus providing paradigms to evaluate treatment effects in drug discovery. The effects of challenges represented by pharmacological agents, hypoxia, sleep deprivation and transcranial magnetic stimulation (TMS) on EEG rhythms are here reviewed to build a knowledge platform for innovative translational models for drug discovery in Alzheimer's disease (AD). It has been reported that antagonists of cholinergic neurotransmission cause synchronisation of spontaneous ongoing EEG rhythms in terms of enhanced power of EEG low frequencies and decreased power of EEG high frequencies. Acetylcholinesterase inhibitors and serotonergic drugs may restore a normal pattern of EEG desynchronisation. Sleep deprivation and hypoxia challenges have also been reported to elicit abnormal synchronisation of spontaneous ongoing EEG rhythms in rodents. The feasibility and reproducibility of TMS have been demonstrated in rodents but information on a consistent modulation of EEG after TMS manipulation is very limited. Transgenic mice over-expressing human amyloid precursor protein complementary DNAs (cDNAs) harbouring the 'Swedish' mutation and PS-1 cDNAs harbouring the A264E mutation, which recapitulate some of the pathological features of AD, exhibit alterations of spontaneous ongoing EEG rhythms at several low and high frequencies. This does not appear, however, to be a consequence of beta-amyloid deposition in the brain. The present review provides a critical evaluation of changes of spontaneous ongoing EEG rhythms due to the experimental manipulations described above, in order to stimulate the promote more adherent models fitting dynamics in humans.
authors.affiliation: Department of Clinical and Experimental Medicine, University of Foggia, Foggia, Italy; IRCCS San Raffaele Pisana, Rome, Italy. c.babiloni@unifg.it
authors.forename: Claudio
authors.initials: C
authors.lastname: Babiloni
authors.forename: Francesco
authors.initials: F
authors.lastname: Infarinato
authors.forename: Fabienne
authors.initials: F
authors.lastname: Aujard
authors.forename: Jesper Frank
authors.initials: JF
authors.lastname: Bastlund
authors.forename: Marina
authors.initials: M
authors.lastname: Bentivoglio
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Bertini
authors.forename: Claudio
authors.initials: C
authors.lastname: Del Percio
authors.forename: Paolo Francesco
authors.initials: PF
authors.lastname: Fabene
authors.forename: Gianluigi
authors.initials: G
authors.lastname: Forloni
authors.forename: Maria Trinidad
authors.initials: MT
authors.lastname: Herrero Ezquerro
authors.forename: Francesco Mattia
authors.initials: FM
authors.lastname: Noè
authors.forename: Fabien
authors.initials: F
authors.lastname: Pifferi
authors.forename: Francisco
authors.initials: F
authors.lastname: Ros-Bernal
authors.forename: Ditte Zerlang
authors.initials: DZ
authors.lastname: Christensen
authors.forename: Sophie
authors.initials: S
authors.lastname: Dix
authors.forename: Jill C
authors.initials: JC
authors.lastname: Richardson
authors.forename: Yves
authors.initials: Y
authors.lastname: Lamberty
authors.forename: Wilhelmus
authors.initials: W
authors.lastname: Drinkenburg
authors.forename: Paolo Maria
authors.initials: PM
authors.lastname: Rossini
mesh_terms: D000544:Alzheimer Disease / Q000188:drug therapy* / Q000503:physiopathology; D000818:Animals; D001921:Brain / Q000503:physiopathology*; D004195:Disease Models, Animal; D004569:Electroencephalography; D000860:Hypoxia / Q000503:physiopathology*; D051379:Mice; D051381:Rats; D012892:Sleep Deprivation / Q000503:physiopathology*; D050781:Transcranial Magnetic Stimulation; D057170:Translational Research, Biomedical