title: Recurrence of peripheral T-cell lymphoma as granulomas in the lower limbs.
abstract: The presence of granulomas in the skin of T-cell lymphoma patients is a rare but well-known phenomenon. The authors present the case of a 44-year-old Caucasian male, with a previously treated peripheral T-cell lymphoma, with cutaneous infiltration and extensive dyschromia on his lower limbs. Skin biopsies revealed the presence of sarcoid granulomas associated with the recurrence of the lymphoma, confirmed by immunostaining and molecular analysis. Although a new scheme of chemotherapy was started, he died 18 months later. There are two different patterns of skin granulomas associated with lymphoma: granulomatous infiltrates admixed with neoplastic cells and cutaneous granulomas constituting a nonspecific manifestation of the underlying lymphoma, but presently there is no evidence supporting their relationship with lymphoma prognosis.
authors.affiliation: Dermatovenereology Department, University Dermatology Clinic, North Lisbon Hospital Center, Santa Maria Hospital, Lisbon, Portugal. ritatravassos@gmail.com
authors.forename: Ana Rita
authors.initials: AR
authors.lastname: Travassos
authors.forename: João
authors.initials: J
authors.lastname: Borges-Costa
authors.forename: João
authors.initials: J
authors.lastname: Raposo
authors.forename: Luís Soares
authors.initials: LS
authors.lastname: Almeida
authors.forename: Paulo
authors.initials: P
authors.lastname: Filipe
mesh_terms: D000328:Adult; D017809:Fatal Outcome; D006099:Granuloma / Q000473:pathology*; D006801:Humans; D016411:Lymphoma, T-Cell, Peripheral / Q000473:pathology*; D008297:Male; D009364:Neoplasm Recurrence, Local / Q000473:pathology*; D012878:Skin Neoplasms / Q000473:pathology*