title: Clostridium septicum growth from a total knee arthroplasty associated with intestinal malignancy: a case report.
abstract: BACKGROUND
  Previous reports of infection with Clostridium septicum have identified an unexpected association with concurrent malignancy. The reported rate of associated malignancy has been found to be as high as 81 percent. The purpose of this case report was to present a case of a total knee arthroplasty infected with C. septicum and the subsequent finding of an occult colonic malignancy.
  
  
  METHODS
  A 74 year-old man underwent uneventful bilateral total knee arthroplasties. Two weeks post-operatively, he presented with acute swelling, redness and pain of the left knee. Aspiration of the knee was sent for cell count and culture. The cell count demonstrated 39,000 white blood cells per cubic millimeter with 71% of white blood cells identified as neutrophils. Synovial fluid cultures identified the presence of C. septicum, Enterobacter and coagulase negative Staphylococcus. After urgent irrigation and debridement and polyethylene exchange of the affected knee, the patient was placed on intravenous Penicillin G for a period of six weeks. Two weeks into his course of antibiotics, the patient developed hematochezia and was found to have an obstructive colonic malignancy. The patient underwent hemi-colectomy and has since made a complete recovery of both his malignancy and total knee arthroplasty infection.
  
  
  CONCLUSIONS
  Recognition of the association between C. septicum and malignancy is especially important considering the large predicted increase in total joint arthroplasty procedures over the coming decades. In addition to the standard treatment for infection after total joint arthroplasty, identification of Clostridium septicum should initiate a search for associated occult malignancy.
authors.affiliation: Department of Orthopaedic Surgery, Philadelphia College of Osteopathic Medicine, Philadelphia, Pa 19131, USA. deconomedes@gmail.com
authors.forename: Demetri M
authors.initials: DM
authors.lastname: Economedes
authors.forename: Jerome
authors.initials: J
authors.lastname: Santoro
authors.forename: Carl A
authors.initials: CA
authors.lastname: Deirmengian
mesh_terms: D000368:Aged; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D001178:Arthroplasty / Q000009:adverse effects*; D003015:Clostridium Infections / Q000175:diagnosis* / Q000382:microbiology / Q000473:pathology; D052557:Clostridium septicum / Q000302:isolation & purification*; D003082:Colectomy; D003110:Colonic Neoplasms / Q000150:complications*; D004754:Enterobacter / Q000302:isolation & purification; D006801:Humans; D007262:Infusions, Intravenous; D007719:Knee Joint / Q000473:pathology; D008297:Male; D010400:Penicillin G / Q000627:therapeutic use; D016459:Prosthesis-Related Infections / Q000175:diagnosis* / Q000382:microbiology / Q000473:pathology; D013210:Staphylococcus / Q000302:isolation & purification; D016896:Treatment Outcome
chemical_list: D000900:Anti-Bacterial Agents; D010400:Penicillin G