title: Effectiveness of low-dose prolonged infusion of tissue plasminogen activator in a nonagenarian patient with acute pulmonary embolism and main pulmonary artery thrombus.
abstract: Acute pulmonary embolism is an important emergency disease which frequently results in life-threatening complication. Systemic fibrinolysis is recommended as standard, first-line therapy in patients with massive pulmonary embolism. In the case described in this report, a 95-year-old woman was treated with low-dose prolonged infusion of tissue plasminogen activator for acute pulmonary embolism and mobile thrombus in the main pulmonary artery and right pulmonary artery. On the basis of echocardiographic findings, acute thrombolysis with low-dose prolonged infusion of tissue plasminogen activator was performed resulting in hemodynamic stabilization of the patient and complete resolution of the pulmonary artery thrombus.
authors.affiliation: Department of Cardiology, Kartal Koşuyolu Yüksek Ihtisas Educational and Research Hospital, Istanbul, Turkey. mustafayilldiz@yahoo.com
authors.forename: Mustafa
authors.initials: M
authors.lastname: Yildiz
authors.forename: Suleyman
authors.initials: S
authors.lastname: Karakoyun
authors.forename: Rezzan Deniz
authors.initials: RD
authors.lastname: Acar
authors.forename: Mehmet
authors.initials: M
authors.lastname: Ozkan
mesh_terms: D000208:Acute Disease; D000369:Aged, 80 and over; D000925:Anticoagulants / Q000008:administration & dosage / Q000627:therapeutic use; D001157:Arterial Occlusive Diseases / Q000150:complications / Q000000981:diagnostic imaging / Q000188:drug therapy*; D057915:Drug Substitution; D004630:Emergencies; D017984:Enoxaparin / Q000008:administration & dosage / Q000627:therapeutic use; D005260:Female; D005343:Fibrinolytic Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D006493:Heparin / Q000008:administration & dosage / Q000627:therapeutic use; D006801:Humans; D006949:Hyperlipidemias / Q000150:complications / Q000188:drug therapy; D006973:Hypertension / Q000150:complications / Q000188:drug therapy; D007262:Infusions, Intravenous; D011651:Pulmonary Artery / Q000000981:diagnostic imaging; D011655:Pulmonary Embolism / Q000150:complications / Q000000981:diagnostic imaging / Q000188:drug therapy*; D015912:Thrombolytic Therapy / Q000379:methods*; D013924:Thrombophlebitis / Q000150:complications / Q000000981:diagnostic imaging; D013927:Thrombosis / Q000150:complications / Q000000981:diagnostic imaging / Q000188:drug therapy*; D010959:Tissue Plasminogen Activator / Q000008:administration & dosage / Q000627:therapeutic use*; D014262:Tricuspid Valve Insufficiency / Q000150:complications / Q000000981:diagnostic imaging; D014463:Ultrasonography
chemical_list: D000925:Anticoagulants; D017984:Enoxaparin; D005343:Fibrinolytic Agents; D006493:Heparin; D010959:Tissue Plasminogen Activator