title: Wound healing after keratorefractive surgery:  review of biological and optical considerations.
abstract: The introduction of the excimer laser for keratorefractive surgery in the 1990 s permanently reshaped the treatment landscape for correcting refractive errors, such as myopia, hyperopia, and astigmatism. Until that point, these treatments had relied on less predictable techniques, such as radial keratotomy and automated lamellar keratectomy. In recent years, other new technologies, along with increased understanding of the basic science of refractive errors, higher-order aberrations, biomechanics, and the biology of corneal wound healing, have allowed for a reduction in the surgical complications of keratorefractive surgery. Novel technologies, such as eye tracking, anterior segment imaging, the femtosecond laser, and asphericity-optimized and wavefront-guided custom laser in situ keratomileusis, have assisted refractive surgeons in achieving greater predictability of their laser vision correction procedures. Understanding the cascade of events involved in the corneal wound healing process and examination of how corneal wound healing influences corneal biomechanics and optics are crucial to improve the efficacy and safety of laser vision correction.
authors.affiliation: Department of Ophthalmology and Visual Sciences, University of Illinois College of Medicine at Chicago, Chicago, IL 60612, USA. dazar@uic.edu
authors.forename: Dimitri T
authors.initials: DT
authors.lastname: Azar
authors.forename: Jin-Hong
authors.initials: JH
authors.lastname: Chang
authors.forename: Kyu Yeon
authors.initials: KY
authors.lastname: Han
mesh_terms: D043925:Angiogenesis Inducing Agents / Q000378:metabolism; D020533:Angiogenesis Inhibitors / Q000378:metabolism; D000818:Animals; D001696:Biomechanical Phenomena / Q000502:physiology*; D003315:Cornea / Q000502:physiology*; D048988:Corneal Surgery, Laser; D006801:Humans; D054018:Lasers, Excimer / Q000627:therapeutic use; D020782:Matrix Metalloproteinases / Q000378:metabolism; D012029:Refraction, Ocular / Q000502:physiology*; D012030:Refractive Errors / Q000503:physiopathology; D014792:Visual Acuity / Q000502:physiology; D014945:Wound Healing / Q000502:physiology*
chemical_list: D043925:Angiogenesis Inducing Agents; D020533:Angiogenesis Inhibitors; D020782:Matrix Metalloproteinases