title: Preparation of 3,4,5-trisubstituted oxazolones by Pd-catalyzed coupling of N-alkynyl tert-butyloxycarbamates with aryl halides and related electrophiles.
abstract: A novel palladium-catalyzed approach for the assembly of 3,4,5-trisubstituted oxazolones has been achieved by the coupling of N-alkynyl tert-butyloxycarbamates with aryl halides and related electrophiles, which involves an oxidative addition followed by oxypalladation/reductive elimination. The reaction provides a convenient access to diversely substituted oxazolones in satisfactory yields and shows good functional group compatibility.
authors.affiliation: Department of Chemistry, Zhejiang Normal University, 688 Yingbin Road, Jinhua 321004, China.
authors.forename: Zenghui
authors.initials: Z
authors.lastname: Lu
authors.forename: Weijian
authors.initials: W
authors.lastname: Cui
authors.forename: Siyuan
authors.initials: S
authors.lastname: Xia
authors.forename: Yihui
authors.initials: Y
authors.lastname: Bai
authors.forename: Fang
authors.initials: F
authors.lastname: Luo
authors.forename: Gangguo
authors.initials: G
authors.lastname: Zhu
mesh_terms: D002384:Catalysis; D006846:Hydrocarbons, Halogenated / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D010081:Oxazolone / Q000737:chemistry*; D010165:Palladium / Q000737:chemistry*
chemical_list: D006846:Hydrocarbons, Halogenated; D010081:Oxazolone; D010165:Palladium