title: Protein carbonyls and traditional biomarkers in pigs exposed to low-dose γ-radiation.
abstract: Response of pigs to irradiation manifested by production of protein carbonyls and adaptable enzymes was studied in two experiments. In one experiment, 10 mixed-sex pigs were exposed to 0.5 Gy whole body (60)Co irradiation. In the other experiment, another batch of 10 pigs was exposed to 1.0 Gy half-body irradiation. Unlike those exposed to half-body irradiation, the pigs exposed to whole-body irradiation showed significant increase in protein carbonyls by 73%, and a decrease in cholesterol by 25.7%, compared to the control group. In both cases of dose-dependent irradiation exposure, pigs showed a decrease in alanine aminotransferase activity compared with the control group. At the dose of 1 Gy, ALT activity decreased significantly by 27.7%. Aspartate aminotransferase activity in pigs after half-body irradiation decreased significantly by 65.5%. Although low doses of ionizing radiation were applied, monitoring of the above biochemical parameters helped define the pigs' biological response.
authors.affiliation: Department of Biochemistry, Chemistry and Biophysics, Faculty of Veterinary Hygiene and Ecology, University of Veterinary and Pharmaceutical Sciences Brno, Czech Republic.
authors.forename: Miriam
authors.initials: M
authors.lastname: Smutná
authors.forename: Katarína
authors.initials: K
authors.lastname: Beňová
authors.forename: Petr
authors.initials: P
authors.lastname: Dvořák
authors.forename: Tomáš
authors.initials: T
authors.lastname: Nekvapil
authors.forename: Vladimír
authors.initials: V
authors.lastname: Kopřiva
authors.forename: Dionýz
authors.initials: D
authors.lastname: Maté
mesh_terms: D000818:Animals; D015415:Biomarkers; D004307:Dose-Response Relationship, Radiation; D005260:Female; D005720:Gamma Rays / Q000009:adverse effects*; D008297:Male; D050050:Protein Carbonylation / Q000528:radiation effects*; D013552:Swine / Q000097:blood*
chemical_list: D015415:Biomarkers