title: Comparison of the obstetric and perinatal outcomes of children conceived from in vitro or in vivo matured oocytes in in vitro maturation treatments with births from conventional ICSI cycles.
abstract: OBJECTIVE
  Are the obstetric and perinatal outcomes of deliveries following in vitro maturation (IVM) cycles different from births generated from controlled ovarian stimulation (COS) cycles?
  
  
  CONCLUSIONS
  The obstetric and perinatal outcomes of births from IVM cycles are comparable with those of ICSI treatments, including the incidence of major and minor abnormalities.
  
  
  BACKGROUND
  Only few and numerically small reports on the health of IVM children are currently available.
  
  
  METHODS
  Retrospective cohort study involving 196 babies born from IVM cycles carried out with different priming regimens. Of these children, 79 developed from oocytes matured in vitro after 30 h of culture, while 104 originated from oocytes found mature and inseminated on the day of recovery. Thirteen babies were obtained from embryos developed from both types of oocytes. Data of these births were compared with those of 194 children born from COS ICSI cycles performed during the same period (March 2004 to December 2011).
  
  
  METHODS
  IVM cycles were done in the absence of gonadotrophin administration or with FSH and/or HCG priming. All oocytes were inseminated by microinjection. ICSI and ICSI cycles were chosen as a control group to exclude possible influences of the insemination technique. Couples in which maternal age was >39 years or affected by azoospermia were excluded to rule out major parental effects.
  
  
  RESULTS
  In single births, gestational age at delivery was comparable, but birthweight was significantly higher (P = 0.009) in children from IVM cycles (3091 ± 669 versus 3269 ± 619 g). In a separate analysis of the IVM group, comparing singleton births derived with certainty from oocytes matured in vitro (n = 71) or in vivo (n = 74), no statistically significant differences were observed in terms of birthweight (3311 ± 637 versus 3194 ± 574 g, respectively) and gestational age (38.9 ± 2.4 versus 38.4 ± 2.1 weeks, respectively). In twin births, gestational age was lower in IVM cycles, while weight at birth was comparable (ICSI, 2432 ± 540 g; IVM, 2311 ± 577 g). In single births, major and minor abnormalities were 2 (1.4%) and 6 (4.1%) in the ICSI group and 0 (0.0%) and 8 (5.2%) in the IVM category, respectively. In twin children, major and minor abnormalities were 1 (2.2%) and 2 (4.3%) in ICSI babies and 0 (0.0%) and 2 (4.6%) in IVM cycles, respectively.
  
  
  CONCLUSIONS
  The study is the largest conducted so far. Nevertheless, it is limited by its retrospective nature and the fact that most births of IVM treatments derived from oocytes found mature at recovery in cycles primed with HCG. A more comprehensive appraisal of the health status of IVM children will demand larger prospective studies.
  
  
  CONCLUSIONS
  The study is consistent with previous reports suggesting a possible role of standard ovarian stimulation in determining a reduced birthweight in children born from COS cycles.
  
  
  BACKGROUND
  No external funding was sought to support this work. The authors have no conflicts of interest to declare.
  
  
  BACKGROUND
  Not applicable.
authors.affiliation: Biogenesi Reproductive Medicine Centre, Istituti Clinici Zucchi, Via Zucchi 24, Monza, Italy.
authors.forename: Rubens
authors.initials: R
authors.lastname: Fadini
authors.forename: Mario
authors.initials: M
authors.lastname: Mignini Renzini
authors.forename: Teresa
authors.initials: T
authors.lastname: Guarnieri
authors.forename: Mariabeatrice
authors.initials: M
authors.lastname: Dal Canto
authors.forename: Elena
authors.initials: E
authors.lastname: De Ponti
authors.forename: Alastair
authors.initials: A
authors.lastname: Sutcliffe
authors.forename: Mark
authors.initials: M
authors.lastname: Shevlin
authors.forename: Ruggero
authors.initials: R
authors.lastname: Comi
authors.forename: Giovanni
authors.initials: G
authors.lastname: Coticchio
mesh_terms: D001724:Birth Weight; D015331:Cohort Studies; D000013:Congenital Abnormalities / Q000453:epidemiology; D005260:Female; D005307:Fertilization in Vitro / Q000379:methods; D005865:Gestational Age; D006801:Humans; D059471:In Vitro Oocyte Maturation Techniques / Q000379:methods*; D007231:Infant, Newborn; D007234:Infant, Premature; D008297:Male; D054315:Oocyte Retrieval / Q000379:methods; D009865:Oocytes / Q000502:physiology*; D010062:Ovulation Induction / Q000379:methods; D011247:Pregnancy; D011256:Pregnancy Outcome; D059285:Pregnancy, Twin; D012189:Retrospective Studies; D020554:Sperm Injections, Intracytoplasmic / Q000379:methods