title: Biomaterial applications in cardiovascular tissue repair and regeneration.
abstract: Cardiovascular disease physically damages the heart, resulting in loss of cardiac function. Medications can help alleviate symptoms, but it is more beneficial to treat the root cause by repairing injured tissues, which gives patients better outcomes. Besides heart transplants, cardiac surgeons use a variety of methods for repairing different areas of the heart such as the ventricular septal wall and valves. A multitude of biomaterials are used in the repair and replacement of impaired heart tissues. These biomaterials fall into two main categories: synthetic and natural. Synthetic materials used in cardiovascular applications include polymers and metals. Natural materials are derived from biological sources such as human donor or harvested animal tissues. A new class of composite materials has emerged to take advantage of the benefits of the strengths and minimize the weaknesses of both synthetic and natural materials. This article reviews the current and prospective applications of biomaterials in cardiovascular therapies.
authors.affiliation: Department of Surgery, Division of Plastic and Reconstructive Surgery, Hagey Pediatric Regenerative Research Laboratory, Stanford University School of Medicine, Stanford, CA, USA.
authors.forename: Mai T
authors.initials: MT
authors.lastname: Lam
authors.forename: Joseph C
authors.initials: JC
authors.lastname: Wu
mesh_terms: D000818:Animals; D001672:Biocompatible Materials / Q000627:therapeutic use*; D001705:Bioprosthesis; D002309:Cardiology / Q000379:methods / Q000639:trends; D002318:Cardiovascular Diseases / Q000601:surgery / Q000628:therapy*; D002320:Cardiovascular Physiological Phenomena; D006801:Humans; D012038:Regeneration; D044968:Regenerative Medicine / Q000379:methods / Q000639:trends; D023822:Tissue Engineering / Q000379:methods / Q000639:trends
chemical_list: D001672:Biocompatible Materials