title: Chemotherapy of leishmaniasis. Part XI: synthesis and bioevaluation of novel isoxazole containing heteroretinoid and its amide derivatives.
abstract: Novel isoxazole containing heteroretinoid (4) and its amide derivatives (5a-j) have been synthesized and evaluated for their in vivo antileishmanial activity against Leishmania donovani in hamsters. Compounds 3, 5a, 5d, 5k and 5l inhibited 70-76% parasite growth at 50 mg kg(-1) ×5 days. The present study has helped us in identifying a new lead that could be exploited as a potential antileishmanial agent.
authors.affiliation: Division of Medicinal Chemistry, CSIR, Central Drug Research Institute, Lucknow 226001, India. shivajins@yahoo.co.in
authors.forename: S N
authors.initials: SN
authors.lastname: Suryawanshi
authors.forename: Avinash
authors.initials: A
authors.lastname: Tiwari
authors.forename: Naveen
authors.initials: N
authors.lastname: Chandra
authors.lastname: Ramesh
authors.forename: Suman
authors.initials: S
authors.lastname: Gupta
mesh_terms: D000577:Amides / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use; D000818:Animals; D000981:Antiprotozoal Agents / Q000138:chemical synthesis* / Q000494:pharmacology* / Q000627:therapeutic use; D006224:Cricetinae; D005260:Female; D007555:Isoxazoles / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use; D007893:Leishmania donovani / Q000187:drug effects*; D007896:Leishmaniasis / Q000188:drug therapy; D008297:Male; D015394:Molecular Structure; D012176:Retinoids / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use
chemical_list: D000577:Amides; D000981:Antiprotozoal Agents; D007555:Isoxazoles; D012176:Retinoids