title: The impact of total antioxidant capacity on pulmonary function in asthma patients.
abstract: BACKGROUND
  Oxidative stress, mediated by an imbalance between oxidants and antioxidants, contributes significantly to the pathogenesis of asthma.
  
  
  OBJECTIVE
  To evaluate the impact of serum total antioxidant capacity (TAC) on the pulmonary function of Korean asthma patients.
  
  
  METHODS
  A total of 104 adult asthma patients enrolled from the COREA (Cohort for Reality and Evolution of Adult Asthma in Korea) programme participated in the study. Baseline clinical parameters at enrolment, and the results of pulmonary function tests at baseline and 1 and 2 years after enrolment  were collected. TAC at baseline was measured using a Trolox-equivalent antioxidant capacity assay. Patients were divided into two groups based on TAC levels, and various clinical parameters were compared.
  
  
  RESULTS
  Serum TAC levels correlated with forced expiratory volume in 1 second (FEV(1))  at baseline (r = 0.22, P = 0.03). The group with higher baseline TAC levels maintained greater mean FEV(1) both 1 and 2 years after enrolment, even after adjusting for sex, age, height, weight, body mass index and smoking status.
  
  
  CONCLUSIONS
  These results suggest  an important link between serum TAC levels and pulmonary function, indicating that higher TAC levels may be a biomarker for favourable prognosis in asthma patients.
authors.affiliation: Division of Allergy and Clinical Immunology, Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea.
authors.forename: S Y
authors.initials: SY
authors.lastname: Yoon
authors.forename: T-B
authors.initials: TB
authors.lastname: Kim
authors.forename: S
authors.initials: S
authors.lastname: Baek
authors.forename: S
authors.initials: S
authors.lastname: Kim
authors.forename: H-S
authors.initials: HS
authors.lastname: Kwon
authors.forename: Y S
authors.initials: YS
authors.lastname: Lee
authors.forename: T
authors.initials: T
authors.lastname: Lee
authors.forename: A-S
authors.initials: AS
authors.lastname: Jang
authors.forename: Y-S
authors.initials: YS
authors.lastname: Chang
authors.forename: S-H
authors.initials: SH
authors.lastname: Cho
authors.forename: B W
authors.initials: BW
authors.lastname: Choi
authors.forename: J W
authors.initials: JW
authors.lastname: Park
authors.forename: D-H
authors.initials: DH
authors.lastname: Nham
authors.forename: H-J
authors.initials: HJ
authors.lastname: Yoon
authors.forename: Y-J
authors.initials: YJ
authors.lastname: Cho
authors.forename: C-S
authors.initials: CS
authors.lastname: Park
authors.forename: H-B
authors.initials: HB
authors.lastname: Moon
authors.forename: Y S
authors.initials: YS
authors.lastname: Cho
mesh_terms: D000328:Adult; D000368:Aged; D000975:Antioxidants / Q000378:metabolism* / Q000494:pharmacology; D001249:Asthma / Q000503:physiopathology*; D015415:Biomarkers / Q000378:metabolism; D002839:Chromans / Q000494:pharmacology; D015331:Cohort Studies; D003430:Cross-Sectional Studies; D005260:Female; D005500:Follow-Up Studies; D005541:Forced Expiratory Volume; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D018384:Oxidative Stress; D011379:Prognosis; D011446:Prospective Studies; D056910:Republic of Korea; D012129:Respiratory Function Tests; D013997:Time Factors
chemical_list: D000975:Antioxidants; D015415:Biomarkers; D002839:Chromans; C010643:6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid