title: In situ doxorubicin-CaP shell formation on amphiphilic gelatin-iron oxide core as a multifunctional drug delivery system with improved cytocompatibility, pH-responsive drug release and MR imaging.
abstract: An amphiphilic gelatin-iron oxide core/calcium phosphate shell (AGIO@CaP-DOX) nanoparticle was successfully synthesized as an efficient anti-cancer drug delivery system, where doxorubicin (DOX) as a model molecule was encapsulated by electrolytic co-deposition during CaP shell formation. The shell of CaP precipitate played a pivotal role, not only in acting as a drug depot, but also in rendering the drug release rate in a highly pH-dependent controlled manner. Together with MR imaging, highly biocompatible drug-carrying CaP shell and efficient cellular internalization, the AGIO@CaP-DOX nanoparticles developed in this study area promising multifunctional nanodevice for nanotherapeutic approaches.
authors.affiliation: Department of Materials Sciences and Engineering, National Chiao Tung University, Hsinchu 30010, Taiwan.
authors.forename: W-M
authors.initials: WM
authors.lastname: Li
authors.forename: S-Y
authors.initials: SY
authors.lastname: Chen
authors.forename: D-M
authors.initials: DM
authors.lastname: Liu
mesh_terms: D002130:Calcium Phosphates / Q000737:chemistry*; D016923:Cell Death / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D004317:Doxorubicin / Q000494:pharmacology*; D016503:Drug Delivery Systems; D005290:Ferric Compounds / Q000737:chemistry*; D005780:Gelatin / Q000737:chemistry*; D006367:HeLa Cells; D006801:Humans; D006863:Hydrogen-Ion Concentration / Q000187:drug effects; D009682:Magnetic Resonance Spectroscopy; D053758:Nanoparticles / Q000648:ultrastructure; D017550:Spectroscopy, Fourier Transform Infrared; D013501:Surface-Active Agents / Q000737:chemistry*
chemical_list: D002130:Calcium Phosphates; D005290:Ferric Compounds; D013501:Surface-Active Agents; C000499:ferric oxide; D004317:Doxorubicin; D005780:Gelatin; C020243:calcium phosphate