title: The antioxidant and anti-inflammatory effects of phenolic compounds isolated from the root of Rhodiola sachalinensis A. BOR.
abstract: Isolation of compounds from the root of Rhodiola sachalinensis (RRS) yielded tyrosol (1), salidroside (2), multiflorin B (3), kaempferol-3,4'-di-O-β-D-glucopyranoside (4), afzelin (5), kaempferol (6), rhodionin (7), and rhodiosin (8). Quantification of these compounds was performed by high-performance liquid chromatography (HPLC). To investigate the antioxidant and anti-inflammatory effects of the compounds, DPPH radical scavenging, NBT superoxide scavenging and nitric oxide production inhibitory activities were examined in LPS-stimulated Raw 264.7 cells. We suggest that the major active components of RRS are herbacetin glycosides, exhibiting antioxidant activity, and kaempferol, exhibiting anti-inflammatory activity.
authors.affiliation: College of Pharmacy, Chung-Ang University, Seoul 156-756, Korea.
authors.forename: Kang In
authors.initials: KI
authors.lastname: Choe
authors.forename: Joo Hee
authors.initials: JH
authors.lastname: Kwon
authors.forename: Kwan Hee
authors.initials: KH
authors.lastname: Park
authors.forename: Myeong Hwan
authors.initials: MH
authors.lastname: Oh
authors.forename: Manh Heun
authors.initials: MH
authors.lastname: Kim
authors.forename: Han Hyuk
authors.initials: HH
authors.lastname: Kim
authors.forename: Su Hyun
authors.initials: SH
authors.lastname: Cho
authors.forename: Eun Kyung
authors.initials: EK
authors.lastname: Chung
authors.forename: Sung Yi
authors.initials: SY
authors.lastname: Ha
authors.forename: Min Won
authors.initials: MW
authors.lastname: Lee
mesh_terms: D000893:Anti-Inflammatory Agents / Q000494:pharmacology*; D000975:Antioxidants / Q000494:pharmacology*; D001713:Biphenyl Compounds / Q000037:antagonists & inhibitors; D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects; D006801:Humans; D009569:Nitric Oxide / Q000096:biosynthesis; D010636:Phenols / Q000494:pharmacology*; D010851:Picrates / Q000037:antagonists & inhibitors; D010936:Plant Extracts / Q000737:chemistry* / Q000494:pharmacology*; D018517:Plant Roots / Q000737:chemistry*; D029771:Rhodiola / Q000737:chemistry*; D013481:Superoxides / Q000037:antagonists & inhibitors
chemical_list: D000893:Anti-Inflammatory Agents; D000975:Antioxidants; D001713:Biphenyl Compounds; D010636:Phenols; D010851:Picrates; D010936:Plant Extracts; D013481:Superoxides; D009569:Nitric Oxide; C004931:1,1-diphenyl-2-picrylhydrazyl