title: Malnutrition-inflammation score is associated with handgrip strength in nondialysis-dependent chronic kidney disease patients.
abstract: OBJECTIVE
  The malnutrition-inflammation score (MIS) is a nutritional scoring system that has been associated with muscle strength among dialysis patients. We aimed to test whether MIS is able to predict muscle strength in nondialysis-dependent chronic kidney disease (NDD-CKD) individuals.
  
  
  METHODS
  This was a cross-sectional study conducted at the Dante Pazzanese Institute of Cardiology, Hypertension, and Nephrology Division outpatient clinic. We evaluated 190 patients with NDD-CKD stages 2-5 (median 59.5 [interquartile range 51.4-66.9] years; 64% men). MIS was calculated without computing dialysis vintage to the scoring. HGS was assessed in the dominant arm. Anthropometric, laboratory, and body composition parameters were recorded.
  
  
  RESULTS
  A strong negative correlation was found between HGS and MIS (r = -0.42; P ≤ .001) in univariate analysis. In multivariate regressions, adjustment for age, sex, diabetes, glomerular filtration rate, body cell mass, and C-reactive protein did not materially diminish these relationships.
  
  
  CONCLUSIONS
  MIS shares strong links with objective measures of muscle strength in NDD-CKD patients.
authors.affiliation: Dante Pazzanese Institute of Cardiology, Department of Nutrition, São Paulo, Brazil.
authors.forename: Fernanda C
authors.initials: FC
authors.lastname: Amparo
authors.forename: Antonio C
authors.initials: AC
authors.lastname: Cordeiro
authors.forename: Juan J
authors.initials: JJ
authors.lastname: Carrero
authors.forename: Lilian
authors.initials: L
authors.lastname: Cuppari
authors.forename: Bengt
authors.initials: B
authors.lastname: Lindholm
authors.forename: Celso
authors.initials: C
authors.lastname: Amodeo
authors.forename: Maria A
authors.initials: MA
authors.lastname: Kamimura
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001823:Body Composition; D015992:Body Mass Index; D002097:C-Reactive Protein / Q000378:metabolism; D003430:Cross-Sectional Studies; D005260:Female; D005919:Glomerular Filtration Rate; D018737:Hand Strength / Q000502:physiology*; D006801:Humans; D007249:Inflammation / Q000150:complications / Q000503:physiopathology*; D008297:Male; D044342:Malnutrition / Q000150:complications / Q000503:physiopathology*; D008875:Middle Aged; D015999:Multivariate Analysis; D009752:Nutritional Status; D006435:Renal Dialysis; D051436:Renal Insufficiency, Chronic / Q000150:complications / Q000503:physiopathology*; D012307:Risk Factors; D014168:Transferrin / Q000378:metabolism; D055815:Young Adult
chemical_list: D014168:Transferrin; D002097:C-Reactive Protein