title: Model T muscle CARs can treat brain tumors.
abstract: Despite standard treatment with resection, radiation, and chemotherapy, glioblastoma remains a deadly disease with a dismal prognosis. Redirecting patient T cells to target the glioblastoma-associated antigen, IL13Rα2, offers a promising translational immunotherapy with the potential to make a meaningful impact for patients with this disease.
authors.affiliation: Brain Tumor Immunotherapy Program, Neurosurgery Division, Department of Surgery, Duke University Medical Center, Durham, North Carolina 27710, USA. laura.a.johnson@duke.edu
authors.forename: Laura A
authors.initials: LA
authors.lastname: Johnson
mesh_terms: D000818:Animals; D005909:Glioblastoma / Q000276:immunology*; D006801:Humans; D053663:Interleukin-13 Receptor alpha2 Subunit / Q000276:immunology*; D011948:Receptors, Antigen, T-Cell / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology*
chemical_list: D053663:Interleukin-13 Receptor alpha2 Subunit; D011948:Receptors, Antigen, T-Cell