title: Facile synthesis of 2-iodo-spiro[indene-1,1'-isobenzofuran]-3'-ones via iodine-promoted cascade cyclization.
abstract: A novel and efficient synthetic approach to substituted 2-iodo-spiro[indene-1,1'-isobenzofuran]-3'-ones has been developed via an iodine-promoted cascade cyclization of 2-(3-hydroxy-3,3-diarylprop-1-yn-1-yl)benzoates. This sequential cascade process is concisely conducted at room temperature. Subsequent palladium-catalyzed Sonogashira, Suzuki, and Heck reactions of the resulting iodides proceed smoothly in good yields.
authors.affiliation: State Key Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou 730000, China.
authors.forename: Hai-Tao
authors.initials: HT
authors.lastname: Zhu
authors.forename: Xue
authors.initials: X
authors.lastname: Dong
authors.forename: Li-Jing
authors.initials: LJ
authors.lastname: Wang
authors.forename: Mei-Jin
authors.initials: MJ
authors.lastname: Zhong
authors.forename: Xue-Yuan
authors.initials: XY
authors.lastname: Liu
authors.forename: Yong-Min
authors.initials: YM
authors.lastname: Liang
mesh_terms: D001572:Benzofurans / Q000138:chemical synthesis* / Q000737:chemistry; D002384:Catalysis; D003500:Cyclization; D007455:Iodine / Q000737:chemistry*; D015394:Molecular Structure; D010165:Palladium / Q000737:chemistry; D013141:Spiro Compounds / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D001572:Benzofurans; D013141:Spiro Compounds; D010165:Palladium; D007455:Iodine