title: Cytomegalovirus Retinitis in an ALL child on exclusive chemotherapy treated successfully with intravitreal ganciclovir alone.
abstract: A child suffering from acute lymphoblastic leukemia on treatment with exclusive chemotherapy presented with vision-threatening cytomegalovirus (CMV) retinitis in 1 eye. Prompt diagnosis and treatment with 3 weekly doses of 2 mg/0.1 mL intravitreal ganciclovir resulted in successful healing of CMV retinitis with restoration of visual acuity. In children with acute lymphoblastic leukemia on exclusive chemotherapy without hematopoietic stem cell transplantation, CMV retinitis has been reported in only 1 case in literature. This child was treated successfully with intravenous ganciclovir. This report highlights the use of successful intravitreal ganciclovir in pediatric age group to avoid side effects of systemic ganciclovir.
authors.affiliation: Department of Ophthalmology, Advanced Eye Centre, Postgraduate Institute for Medical Education and Research, Chandigarh, India. mankoo95@yahoo.com
authors.forename: Ramandeep
authors.initials: R
authors.lastname: Singh
authors.forename: Rishiraj
authors.initials: R
authors.lastname: Singh
authors.forename: Amita
authors.initials: A
authors.lastname: Trehan
authors.forename: Richa
authors.initials: R
authors.lastname: Jain
authors.forename: Swapnil
authors.initials: S
authors.lastname: Bhalekar
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects*; D000998:Antiviral Agents / Q000627:therapeutic use*; D002648:Child; D003587:Cytomegalovirus / Q000187:drug effects / Q000472:pathogenicity; D017726:Cytomegalovirus Retinitis / Q000139:chemically induced / Q000188:drug therapy* / Q000821:virology; D015774:Ganciclovir / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000150:complications / Q000188:drug therapy* / Q000821:virology; D011379:Prognosis; D014792:Visual Acuity / Q000187:drug effects*; D014822:Vitreous Body / Q000187:drug effects*
chemical_list: D000998:Antiviral Agents; D015774:Ganciclovir