title: Sleep deprivation has a neuroprotective role in a traumatic brain injury of the rat.
abstract: During the process of a brain injury, responses to produce damage and cell death are activated, but self-protective responses that attempt to maintain the integrity and functionality of the brain are also activated. We have previously reported that the recovery from a traumatic brain injury (TBI) is better in rats if it occurs during the dark phase of the diurnal cycle when rats are in the waking period. This suggests that wakefulness causes a neuroprotective role in this type of injury. Here we report that 24h of total sleep deprivation after a TBI reduces the morphological damage and enhances the recovery of the rats, as seen on a neurobiological scale.
authors.affiliation: Depto. Fisiologia Facultad de Medicina, Universidad Nacional Autonoma de Mexico. Apdo, Postal 70-250, Mexico D.F. 04510, Mexico.
authors.forename: Marina
authors.initials: M
authors.lastname: Martinez-Vargas
authors.forename: Francisco
authors.initials: F
authors.lastname: Estrada Rojo
authors.forename: Erika
authors.initials: E
authors.lastname: Tabla-Ramon
authors.forename: Hilda
authors.initials: H
authors.lastname: Navarro-Argüelles
authors.forename: Nathan
authors.initials: N
authors.lastname: Ortiz-Lailzon
authors.forename: Alejandro
authors.initials: A
authors.lastname: Hernández-Chávez
authors.forename: Barbara
authors.initials: B
authors.lastname: Solis
authors.forename: Ricardo
authors.initials: R
authors.lastname: Martínez Tapia
authors.forename: Adan
authors.initials: A
authors.lastname: Perez Arredondo
authors.forename: Julio
authors.initials: J
authors.lastname: Morales-Gomez
authors.forename: Ruben
authors.initials: R
authors.lastname: Gonzalez-Rivera
authors.forename: Karen
authors.initials: K
authors.lastname: Nava-Talavera
authors.forename: Luz
authors.initials: L
authors.lastname: Navarro
mesh_terms: D000818:Animals; D001921:Brain / Q000473:pathology*; D001930:Brain Injuries / Q000473:pathology*; D002940:Circadian Rhythm; D003624:Darkness; D004326:Drinking; D004435:Eating; D008297:Male; D009044:Motor Cortex / Q000473:pathology; D051381:Rats; D017208:Rats, Wistar; D012892:Sleep Deprivation; D012895:Sleep, REM; D013003:Somatosensory Cortex / Q000473:pathology; D013997:Time Factors