title: [Combined spectral karyotyping and microarray-based comparative genomic hybridization for the diagnosis of a case with ring chromosome 15].
abstract: OBJECTIVE
  To assess the value of spectral karyotyping (SKY) combined with microarray-based comparative genomic hybridization (array-CGH) for the diagnosis of complex ring chromosome aberration.
  
  
  METHODS
  For an 8-year-old boy featuring growth retardation, G-banding analysis has indicated a 46,XY,r(15)? karyotype, which was delineated by SKY in combination with array-CGH.
  
  
  RESULTS
  The ring chromosome has originated from chromosome 15 according to SKY analysis. Position of the breakpoint (15q26.3) and a 594 kb deletion were revealed by array-CGH.
  
  
  CONCLUSIONS
  Molecular cytogenetic technologies are efficient tools for clarifying complex chromosomal abnormality, which has provided a powerful tool for conventional cytogenetic analysis.
authors.affiliation: Guangzhou Medical College, Guangzhou, Guangdong, People's Republic of China.
authors.forename: Min
authors.initials: M
authors.lastname: Pan
authors.forename: Kwong Wai
authors.initials: KW
authors.lastname: Choy
authors.forename: Can
authors.initials: C
authors.lastname: Liao
authors.forename: Tze Kin
authors.initials: TK
authors.lastname: Lau
mesh_terms: D002648:Child; D002884:Chromosomes, Human, Pair 15; D055028:Comparative Genomic Hybridization / Q000379:methods*; D006801:Humans; D008297:Male; D009030:Mosaicism; D020411:Oligonucleotide Array Sequence Analysis; D012303:Ring Chromosomes; D032681:Spectral Karyotyping