title: The impact of human epidermal growth factor receptor-2 status of invasive breast tumors on thermography findings.
abstract: OBJECTIVE
  To analyze the impact of prognostic human epidermal growth factor receptor-2 (HER-2) in invasive breast cancers on the findings of thermography tests.
  
  
  METHODS
  The study was carried out at the Department of Surgical Oncology and the Department of Pathology, University Clinical Hospital Center,   Sisters of Mercy, Zagreb, Croatia,  in collaboration with licensed infrared (IR) thermography experts. The study involved 75 female patients diagnosed with invasive breast cancer from May to July 2011. Thermography findings were compared between different immune-histochemical (IHC) findings (HER-2 status: positive or negative).
  
  
  RESULTS
  Significantly higher temperatures were recorded in invasive cancer breasts than in healthy breasts. The cancer sites and the entire cancer breasts were significantly warmer (p less than 0.001) than the healthy breasts and opposite tumors mirror sites. Considering the HER-2 status, HER-2 positive invasive cancers were significantly warmer in comparison with the HER-2 negative cancers (p=0.035).
  
  
  CONCLUSIONS
  The trend of increased temperature in HER-2+ tumors was noted. The findings clearly indicate that HER-2+ status has a higher impact on the increased thermographic temperature findings.
authors.affiliation: Department of Surgical Oncology, University Clinical Hospital Center, Sisters of Mercy, Ilica 197, Zagreb, Croatia. zore.zvonimir@gmail.com
authors.forename: Zvonimir
authors.initials: Z
authors.lastname: Zore
authors.forename: Ivanka
authors.initials: I
authors.lastname: Boras
authors.forename: Irina
authors.initials: I
authors.lastname: Filipovic-Zore
authors.forename: Mladen
authors.initials: M
authors.lastname: Stanec
authors.forename: Miroslav
authors.initials: M
authors.lastname: Lesar
authors.forename: Danko V
authors.initials: DV
authors.lastname: Vrdoljak
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001943:Breast Neoplasms / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D005260:Female; D018734:Genes, erbB-2; D006801:Humans; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D018719:Erb-b2 Receptor Tyrosine Kinases / Q000378:metabolism*; D013817:Thermography
chemical_list: D018719:Erb-b2 Receptor Tyrosine Kinases; C508053:ERBB2 protein, human