title: PRRC2A and BCL2L11 gene variants influence risk of non-Hodgkin lymphoma: results from the InterLymph consortium.
abstract: Many common genetic variants have been associated with non-Hodgkin lymphoma (NHL), but individual study results are often conflicting. To confirm the role of putative risk alleles in B-cell NHL etiology, we performed a validation genotyping study of 67 candidate single nucleotide polymorphisms within InterLymph, a large international consortium of NHL case-control studies. A meta-analysis was performed on data from 5633 B-cell NHL cases and 7034 controls from 8 InterLymph studies. rs3789068 in the proapoptotic BCL2L11 gene was associated with an increased risk for B-cell NHL (odds ratio = 1.21, P random = 2.21 × 10(-11)), with similar risk estimates for common B-cell subtypes. PRRC2A rs3132453 in the HLA complex class III region conferred a reduced risk of B-cell NHL (odds ratio = 0.68, P random = 1.07 × 10(-9)) and was likewise evident for common B-cell subtypes. These results are consistent with the known biology of NHL and provide insights into shared pathogenic components, including apoptosis and immune regulation, for the major B-cell lymphoma subtypes.
authors.affiliation: Centre of Chronic Immunodeficiency, University Medical Center Freiburg,Engesser Strasse4, Freiburg, Germany. alexandra.nieters@uniklinikfreiburg
authors.forename: Alexandra
authors.initials: A
authors.lastname: Nieters
authors.forename: Lucia
authors.initials: L
authors.lastname: Conde
authors.forename: Susan L
authors.initials: SL
authors.lastname: Slager
authors.forename: Angela
authors.initials: A
authors.lastname: Brooks-Wilson
authors.forename: Lindsay
authors.initials: L
authors.lastname: Morton
authors.forename: Danica R
authors.initials: DR
authors.lastname: Skibola
authors.forename: Anne J
authors.initials: AJ
authors.lastname: Novak
authors.forename: Jacques
authors.initials: J
authors.lastname: Riby
authors.forename: Stephen M
authors.initials: SM
authors.lastname: Ansell
authors.forename: Eran
authors.initials: E
authors.lastname: Halperin
authors.forename: Tait D
authors.initials: TD
authors.lastname: Shanafelt
authors.forename: Luz
authors.initials: L
authors.lastname: Agana
authors.forename: Alice H
authors.initials: AH
authors.lastname: Wang
authors.forename: Anneclaire J
authors.initials: AJ
authors.lastname: De Roos
authors.forename: Richard K
authors.initials: RK
authors.lastname: Severson
authors.forename: Wendy
authors.initials: W
authors.lastname: Cozen
authors.forename: John
authors.initials: J
authors.lastname: Spinelli
authors.forename: Katja
authors.initials: K
authors.lastname: Butterbach
authors.forename: Nikolaus
authors.initials: N
authors.lastname: Becker
authors.forename: Silvia
authors.initials: S
authors.lastname: de Sanjose
authors.forename: Yolanda
authors.initials: Y
authors.lastname: Benavente
authors.forename: Pierluigi
authors.initials: P
authors.lastname: Cocco
authors.forename: Anthony
authors.initials: A
authors.lastname: Staines
authors.forename: Marc
authors.initials: M
authors.lastname: Maynadié
authors.forename: Lenka
authors.initials: L
authors.lastname: Foretova
authors.forename: Paolo
authors.initials: P
authors.lastname: Boffetta
authors.forename: Paul
authors.initials: P
authors.lastname: Brennan
authors.forename: Qing
authors.initials: Q
authors.lastname: Lan
authors.forename: Yawei
authors.initials: Y
authors.lastname: Zhang
authors.forename: Tongzhang
authors.initials: T
authors.lastname: Zheng
authors.forename: Mark
authors.initials: M
authors.lastname: Purdue
authors.forename: Bruce
authors.initials: B
authors.lastname: Armstrong
authors.forename: Anne
authors.initials: A
authors.lastname: Kricker
authors.forename: Claire M
authors.initials: CM
authors.lastname: Vajdic
authors.forename: Andrew
authors.initials: A
authors.lastname: Grulich
authors.forename: Martyn T
authors.initials: MT
authors.lastname: Smith
authors.forename: Paige M
authors.initials: PM
authors.lastname: Bracci
authors.forename: Stephen J
authors.initials: SJ
authors.lastname: Chanock
authors.forename: Patricia
authors.initials: P
authors.lastname: Hartge
authors.forename: James R
authors.initials: JR
authors.lastname: Cerhan
authors.forename: Sophia S
authors.initials: SS
authors.lastname: Wang
authors.forename: Nathaniel
authors.initials: N
authors.lastname: Rothman
authors.forename: Christine F
authors.initials: CF
authors.lastname: Skibola
mesh_terms: D051017:Apoptosis Regulatory Proteins / Q000235:genetics*; D000072224:Bcl-2-Like Protein 11; D016022:Case-Control Studies; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D005838:Genotype; D006801:Humans; D008228:Lymphoma, Non-Hodgkin / Q000235:genetics*; D008297:Male; D008565:Membrane Proteins / Q000235:genetics*; D015201:Meta-Analysis as Topic; D016017:Odds Ratio; D020641:Polymorphism, Single Nucleotide; D011506:Proteins / Q000235:genetics*; D011518:Proto-Oncogene Proteins / Q000235:genetics*; D012307:Risk Factors
chemical_list: D051017:Apoptosis Regulatory Proteins; C000606775:BCL2L11 protein, human; D000072224:Bcl-2-Like Protein 11; D008565:Membrane Proteins; D011506:Proteins; D011518:Proto-Oncogene Proteins; C092008:PRRC2A protein, human