title: Piperacillin-induced thrombocytopenia reversed by high-flux hemodialysis in an uremic patient.
abstract: Drug-induced thrombocytopenia in an infected patient often is overlooked. We present a 74-year-old uremic female with continuous renal replacement therapy developed severe thrombocytopenia during the treatment course of piperacillin/tazobactam. Platelet counts recovered rapidly after discontinuing piperacillin/tazobactam and receiving high-flux hemodialysis. The George criteria indicates piperacillin/tazobactam as the probable cause of thrombocytopenia in this patient. Immediate withdrawal of the causative drug is important for drug-induced thrombocytopenia. Prompt high-flux hemodialysis may be an adjunctive management for uremic patients.
authors.affiliation: Department of Internal Medicine, Kaohsiung Municipal Ta-Tung Hospital, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan.
authors.forename: Shang-Yi
authors.initials: SY
authors.lastname: Lin
authors.forename: Jiun-Chi
authors.initials: JC
authors.lastname: Huang
authors.forename: Mei-Chiou
authors.initials: MC
authors.lastname: Shen
authors.forename: Shu-Hui
authors.initials: SH
authors.lastname: Chuang
authors.forename: Mei-Hsuan
authors.initials: MH
authors.lastname: Lee
authors.forename: Huang-Chi
authors.initials: HC
authors.lastname: Chen
mesh_terms: D000368:Aged; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000009:adverse effects*; D004791:Enzyme Inhibitors / Q000008:administration & dosage / Q000009:adverse effects; D005260:Female; D006801:Humans; D010397:Penicillanic Acid / Q000008:administration & dosage / Q000009:adverse effects / Q000031:analogs & derivatives; D010878:Piperacillin / Q000008:administration & dosage / Q000009:adverse effects*; D010976:Platelet Count; D006435:Renal Dialysis; D000078142:Tazobactam; D013921:Thrombocytopenia / Q000097:blood / Q000139:chemically induced* / Q000628:therapy*; D014511:Uremia / Q000097:blood / Q000188:drug therapy*
chemical_list: D000900:Anti-Bacterial Agents; D004791:Enzyme Inhibitors; D010397:Penicillanic Acid; D000078142:Tazobactam; D010878:Piperacillin