title: Bioactive oligostilbenoids from Shorea maxwelliana King and their chemotaxonomic significance.
abstract: Phytochemical investigation on the stem bark of Shorea maxwelliana yielded five oligostilbenoids identified as α-viniferin (1), maximol A (2), vaticanol A (3), suffruticosol A (4) and vaticanol G (5). Chemotaxonomy of isolated compounds was discussed briefly. Major compounds were tested for neurotoxic and cytotoxic activities. Neurotoxicity for all tested compounds did not pose any toxic effect against cultured cell (cell viability range ±100-94%). Compounds 2-5 possessed active cyctotoxic activity against HL60 cell line with IC50 values range of 2.7-78 µg mL(-1).
authors.affiliation: Faculty of Applied Sciences, Universiti Teknologi MARA (UiTM), 40450, Shah Alam, Malaysia.
authors.forename: N K N A
authors.initials: NK
authors.lastname: Zawawi
authors.forename: N
authors.initials: N
authors.lastname: Ahmat
authors.forename: M Z
authors.initials: MZ
authors.lastname: Mazatulikhma
authors.forename: R M
authors.initials: RM
authors.lastname: Shafiq
authors.forename: N H
authors.initials: NH
authors.lastname: Wahid
authors.forename: A S
authors.initials: AS
authors.lastname: Sufian
mesh_terms: D001572:Benzofurans / Q000737:chemistry / Q000494:pharmacology; D002470:Cell Survival / Q000187:drug effects; D053958:Dipterocarpaceae / Q000737:chemistry*; D018922:HL-60 Cells; D006801:Humans; D024301:Plant Bark / Q000737:chemistry*; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology; D013267:Stilbenes / Q000737:chemistry* / Q000494:pharmacology
chemical_list: D001572:Benzofurans; D010936:Plant Extracts; D013267:Stilbenes; C064176:alpha-viniferin