title: Evaluation of antihypertensive and antihyperlipidemic effects of bamboo shoot angiotensin converting enzyme inhibitory peptide in vivo.
abstract: Cardiovascular protective functions of bamboo shoot angiotensin converting enzyme (ACE) inhibitory peptide (BSP) from bamboo shoot were evaluated, including antihypertensive effect on spontaneously hypertensive rats (SHRs) and antihyperlipidemic effect on high-fat-diet-induced rats. Thirty-day antihypertensive effects of BSP on SHRs were assayed. Asp-Tyr [10 mg/day kg body weight (BW)] and BSP (50 mg/day kg BW) significantly reduced ACE activity in lung at the same level (p < 0.05), while BSP (50 mg/day kg BW) reduced systolic blood pressure (SBP) more effectively for its phenolic compounds, such as ferulic acid and p-coumaric acid, which when combined with ACE inhibitor exert a synergistic effect. BSP could significantly reduce SBP, improve oxidant stress status (GSH-Px, SOD, TAC and MDA), and increase NO level in serum and NOS activity in kidney. BSP decreased total cholesterol (TC), triglyceride (TG), and low-density lipoprotein cholesterol (LDL-c) content and MDA level of hyperlipidemic rats, which might contribute to the ACE inhibitory capacity of Asp-Tyr and the fatty acid synthase inhibitory activity of phenolic compounds.
authors.affiliation: Department of Food Science and Nutrition, School of Biosystems Engineering and Food Science, Zhejiang University, Hangzhou, 310058 Zhejiang, PR China.
authors.forename: Lianliang
authors.initials: L
authors.lastname: Liu
authors.forename: Lingyi
authors.initials: L
authors.lastname: Liu
authors.forename: Baiyi
authors.initials: B
authors.lastname: Lu
authors.forename: Daozong
authors.initials: D
authors.lastname: Xia
authors.forename: Ying
authors.initials: Y
authors.lastname: Zhang
mesh_terms: D000806:Angiotensin-Converting Enzyme Inhibitors / Q000008:administration & dosage*; D000818:Animals; D000959:Antihypertensive Agents / Q000008:administration & dosage*; D001794:Blood Pressure / Q000187:drug effects; D003373:Coumaric Acids / Q000008:administration & dosage; D006801:Humans; D006949:Hyperlipidemias / Q000188:drug therapy* / Q000378:metabolism / Q000503:physiopathology; D006973:Hypertension / Q000188:drug therapy* / Q000378:metabolism / Q000503:physiopathology; D000960:Hypolipidemic Agents / Q000008:administration & dosage*; D008297:Male; D018384:Oxidative Stress / Q000187:drug effects; D010455:Peptides / Q000008:administration & dosage*; D010936:Plant Extracts / Q000008:administration & dosage*; D018520:Plant Shoots / Q000737:chemistry; D006109:Poaceae / Q000737:chemistry*; D051381:Rats; D011918:Rats, Inbred SHR
chemical_list: D000806:Angiotensin-Converting Enzyme Inhibitors; D000959:Antihypertensive Agents; D003373:Coumaric Acids; D000960:Hypolipidemic Agents; D010455:Peptides; D010936:Plant Extracts