title: No rest for the weary: diastolic calcium homeostasis in the normal and failing myocardium.
abstract: Following contraction of the heart, efficient relaxation (diastole) is essential for refilling the ventricles with blood. This review describes how ventricular relaxation is controlled by Ca(2+) homeostasis in cardiac muscle cells and how alterations in Ca(2+) cycling affect diastolic function in the normal and failing heart. These discussions illustrate that the diastolic phase is not simply a period of rest but rather involves highly regulated and dynamic Ca(2+) fluxes.
authors.affiliation: Institute for Experimental Medical Research, Oslo University Hospital and University of Oslo, Oslo, Norway. w.e.louch@medisin.uio.no
authors.forename: William E
authors.initials: WE
authors.lastname: Louch
authors.forename: Mathis K
authors.initials: MK
authors.lastname: Stokke
authors.forename: Ivar
authors.initials: I
authors.lastname: Sjaastad
authors.forename: Geir
authors.initials: G
authors.lastname: Christensen
authors.forename: Ole M
authors.initials: OM
authors.lastname: Sejersted
mesh_terms: D000200:Action Potentials / Q000502:physiology; D000818:Animals; D002118:Calcium / Q000378:metabolism*; D009202:Cardiomyopathies / Q000378:metabolism* / Q000503:physiopathology; D003971:Diastole / Q000502:physiology; D004195:Disease Models, Animal; D006706:Homeostasis / Q000502:physiology*; D006801:Humans; D051379:Mice; D009206:Myocardium / Q000166:cytology / Q000378:metabolism*; D051381:Rats; D053498:Sarcoplasmic Reticulum Calcium-Transporting ATPases / Q000502:physiology
chemical_list: D053498:Sarcoplasmic Reticulum Calcium-Transporting ATPases; D002118:Calcium