title: A case of severe acute hepatitis a complicated with pure red cell aplasia.
abstract: Hepatitis A is typically a self-limited acute illness that does not progress to chronic hepatitis. In rare cases, acute hepatitis A can be associated with serious complications (such as fulminant hepatitis or acute kidney injury) and may result in death or liver transplantation. Pure red cell aplasia (PRCA) is a rare hematologic disorder characterized by anemia, reticulocytopenia in the blood, and isolated erythroblastopenia with normal granulopoiesis and megakaryopoiesis in the bone marrow. PRCA is a rare hematopoietic complication of acute viral hepatitis, and few cases associated with hepatitis A virus infection have been reported. Recently, we experienced a case of severe hepatitis A complicated by fulminant hepatitis and acute kidney injury followed by PRCA which showed a favorable response to oral corticosteroids.
authors.affiliation: Department of Internal Medicine, Research Institute of Clinical Medicine, Chonbuk National University Medical School, Jeonju, Korea.
authors.forename: Pyoung Suk
authors.initials: PS
authors.lastname: Lim
authors.forename: In Hee
authors.initials: IH
authors.lastname: Kim
authors.forename: Seong Hun
authors.initials: SH
authors.lastname: Kim
authors.forename: Seung Ok
authors.initials: SO
authors.lastname: Lee
authors.forename: Sang Wook
authors.initials: SW
authors.lastname: Kim
mesh_terms: D000208:Acute Disease; D058186:Acute Kidney Injury / Q000209:etiology; D000328:Adult; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D001853:Bone Marrow / Q000473:pathology; D005260:Female; D006506:Hepatitis A / Q000150:complications / Q000175:diagnosis*; D006801:Humans; D011241:Prednisone / Q000627:therapeutic use; D012010:Red-Cell Aplasia, Pure / Q000150:complications / Q000175:diagnosis* / Q000188:drug therapy
chemical_list: D000893:Anti-Inflammatory Agents; D011241:Prednisone