title: Organocatalytic asymmetric allylic amination of Morita-Baylis-Hillman carbonates of isatins.
abstract: The investigation of a Lewis base catalyzed asymmetric allylic amination of Morita-Baylis-Hillman carbonates derived from isatins afforded an electrophilic pathway to access multifunctional oxindoles bearing a C3-quaternary stereocenter, provided with good to excellent enantioselectivity (up to 94% ee) and in high yields (up to 97%).
authors.affiliation: Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry, Department of Medicinal Chemistry, West China School of Pharmacy, Sichuan University, Chengdu 610041, China.
authors.forename: Hang
authors.initials: H
authors.lastname: Zhang
authors.forename: Shan-Jun
authors.initials: SJ
authors.lastname: Zhang
authors.forename: Qing-Qing
authors.initials: QQ
authors.lastname: Zhou
authors.forename: Lin
authors.initials: L
authors.lastname: Dong
authors.forename: Ying-Chun
authors.initials: YC
authors.lastname: Chen