title: miR-EdiTar: a database of predicted A-to-I edited miRNA target sites.
abstract: BACKGROUND
  A-to-I RNA editing is an important mechanism that consists of the conversion of specific adenosines into inosines in RNA molecules. Its dysregulation has been associated to several human diseases including cancer. Recent work has demonstrated a role for A-to-I editing in microRNA (miRNA)-mediated gene expression regulation. In fact, edited forms of mature miRNAs can target sets of genes that differ from the targets of their unedited forms. The specific deamination of mRNAs can generate novel binding sites in addition to potentially altering existing ones.
  
  
  RESULTS
  This work presents miR-EdiTar, a database of predicted A-to-I edited miRNA binding sites. The database contains predicted miRNA binding sites that could be affected by A-to-I editing and sites that could become miRNA binding sites as a result of A-to-I editing.
  
  
  BACKGROUND
  miR-EdiTar is freely available online at http://microrna.osumc.edu/mireditar.
  
  
  BACKGROUND
  alessandro.lagana@osumc.edu or carlo.croce@osumc.edu
  
  
  BACKGROUND
  Supplementary data are available at Bioinformatics online.
authors.affiliation: Department of Molecular Virology, Immunology and Medical Genetics, Comprehensive Cancer Center, The Ohio State University, Columbus, OH, USA. alessandro.lagana@osumc.edu
authors.forename: Alessandro
authors.initials: A
authors.lastname: Laganà
authors.forename: Alessio
authors.initials: A
authors.lastname: Paone
authors.forename: Dario
authors.initials: D
authors.lastname: Veneziano
authors.forename: Luciano
authors.initials: L
authors.lastname: Cascione
authors.forename: Pierluigi
authors.initials: P
authors.lastname: Gasparini
authors.forename: Stefania
authors.initials: S
authors.lastname: Carasi
authors.forename: Francesco
authors.initials: F
authors.lastname: Russo
authors.forename: Giovanni
authors.initials: G
authors.lastname: Nigita
authors.forename: Valentina
authors.initials: V
authors.lastname: Macca
authors.forename: Rosalba
authors.initials: R
authors.lastname: Giugno
authors.forename: Alfredo
authors.initials: A
authors.lastname: Pulvirenti
authors.forename: Dennis
authors.initials: D
authors.lastname: Shasha
authors.forename: Alfredo
authors.initials: A
authors.lastname: Ferro
authors.forename: Carlo M
authors.initials: CM
authors.lastname: Croce
mesh_terms: D000241:Adenosine / Q000235:genetics; D001665:Binding Sites / Q000235:genetics*; D030541:Databases, Genetic; D005786:Gene Expression Regulation; D006801:Humans; D007288:Inosine / Q000235:genetics; D020407:Internet; D035683:MicroRNAs / Q000235:genetics*; D009690:Nucleic Acid Conformation; D017393:RNA Editing
chemical_list: D035683:MicroRNAs; D007288:Inosine; D000241:Adenosine