title: Simulation of 20-year deterioration of acrylic IOLs using severe accelerated deterioration tests.
abstract: OBJECTIVE
  To investigate IOL deterioration by conducting severe accelerated deterioration testing of acrylic IOLs.
  
  
  METHODS
  Department of Ophthalmology, Tokai University School of Medicine Methods: Severe accelerated deterioration tests performed on 7 types of acrylic IOLs simulated 20 years of deterioration. IOLs were placed in a screw tube bottle containing ultra-pure water and kept in an oven (100°C) for 115 days. Deterioration was determined based the outer appearance of the IOL in water and under air-dried conditions using an optical microscope. For accelerated deterioration of polymeric material, the elapse of 115 days was considered to be equivalent to 20 years based on the Arrhenius equation.
  
  
  RESULTS
  All of the IOLs in the hydrophobic acrylic group except for AU6 showed glistening-like opacity. The entire optical sections of MA60BM and SA60AT became yellowish white in color. Hydrophilic acrylic IOL HP60M showed no opacity at any of the time points examined.
  
  
  CONCLUSIONS
  Our data based on accelerated testing showed differences in water content to play a major role in transparency. There were differences in opacity among manufacturers. The method we have used for determining the relative time of IOL deterioration might not represent the exact clinical setting, but the appearance of the materials would presumably be very similar to that seen in patients.
authors.affiliation: Department of Ophthalmology, Tokai University School of Medicine, Isehara, Kanagawa, Japan. k-kawai@is.icc.u-tokai.ac.jp
authors.forename: Kenji
authors.initials: K
authors.lastname: Kawai
authors.forename: Kenji
authors.initials: K
authors.lastname: Hayakawa
authors.forename: Takahiro
authors.initials: T
authors.lastname: Suzuki
mesh_terms: D000180:Acrylic Resins / Q000737:chemistry; D001672:Biocompatible Materials / Q000737:chemistry; D019544:Equipment Failure Analysis / Q000379:methods* / Q000706:statistics & numerical data; D006358:Hot Temperature / Q000009:adverse effects; D006801:Humans; D057927:Hydrophobic and Hydrophilic Interactions; D007564:Japan; D007910:Lenses, Intraocular / Q000009:adverse effects*; D008422:Materials Testing / Q000379:methods; D055620:Optical Phenomena; D013997:Time Factors
chemical_list: D000180:Acrylic Resins; D001672:Biocompatible Materials