title: Iloprost inhalation in mild asthma.
abstract: OBJECTIVE
  To determine the feasibility of administering iloprost by inhalation in patients with mild atopic asthma.
  
  
  METHODS
  Volunteers underwent supervised inhalation of iloprost in the clinic with measurement of spirometry and blood pressure for 2 hours. The volunteers then inhaled iloprost four times daily at a dose of 2.5 or 5 μg for 14 days. Spirometry, asthma questionnaires, peak flow diaries, measurement of methacholine responsiveness, and exhaled nitric oxide concentrations were obtained prior to and after the treatment period.
  
  
  RESULTS
  Chronic inhalation of iloprost (2.5-5 μg) did not alter spirometry or methacholine responsiveness.
  
  
  CONCLUSIONS
  Inhaled iloprost in carefully selected volunteers with mild asthma appears to be a suitable intervention to explore the effects of prostacyclin in human asthma.
authors.affiliation: Allergy, Pulmonary and Critical Care Medicine Division, Vanderbilt University School of Medicine, Nashville, TN, USA.
authors.forename: Elizabeth
authors.initials: E
authors.lastname: Majeski
authors.forename: Aimee
authors.initials: A
authors.lastname: Hoskins
authors.forename: Ryszard
authors.initials: R
authors.lastname: Dworski
authors.forename: James R
authors.initials: JR
authors.lastname: Sheller
mesh_terms: D000280:Administration, Inhalation; D000328:Adult; D001249:Asthma / Q000188:drug therapy*; D001794:Blood Pressure / Q000187:drug effects; D016535:Bronchial Hyperreactivity; D004305:Dose-Response Relationship, Drug; D005260:Female; D006801:Humans; D016285:Iloprost / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D009569:Nitric Oxide; D044062:Prostaglandins I / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D013147:Spirometry
chemical_list: D044062:Prostaglandins I; D009569:Nitric Oxide; D016285:Iloprost