title: Neonatal hemolytic uremic syndrome after mother-to-child transmission of a low-pathogenic stx2b harboring shiga toxin-producing Escherichia coli.
abstract: This case describes evidence for a Shiga toxin-producing Escherichia coli (STEC) O146:H28 infection leading to hemolytic uremic syndrome in a neonate. STEC O146:H28 was linked hitherto with asymptomatic carriage in humans. Based on strain characteristics and genotyping data, the mother is a healthy carrier who transmitted the STEC during delivery. STEC strains belonging to the low-pathogenic STEC group must also be considered in the workup of neonatal hemolytic uremic syndrome.
authors.affiliation: University Children's Hospital,  Inselspital and University of Bern,  Switzerland.
authors.forename: Andrea
authors.initials: A
authors.lastname: Stritt
authors.forename: Sibylle
authors.initials: S
authors.lastname: Tschumi
authors.forename: Lisa
authors.initials: L
authors.lastname: Kottanattu
authors.forename: Barbara S
authors.initials: BS
authors.lastname: Bucher
authors.forename: Markus
authors.initials: M
authors.lastname: Steinmann
authors.forename: Niklaus
authors.initials: N
authors.lastname: von Steiger
authors.forename: Roger
authors.initials: R
authors.lastname: Stephan
authors.forename: Herbert
authors.initials: H
authors.lastname: Hächler
authors.forename: Giacomo D
authors.initials: GD
authors.lastname: Simonetti
mesh_terms: D000927:Anticonvulsants / Q000627:therapeutic use; D002353:Carrier State / Q000382:microbiology; D004927:Escherichia coli Infections / Q000382:microbiology / Q000635:transmission*; D005243:Feces / Q000382:microbiology; D006463:Hemolytic-Uremic Syndrome / Q000382:microbiology*; D006801:Humans; D007231:Infant, Newborn; D018445:Infectious Disease Transmission, Vertical; D008297:Male; D012640:Seizures / Q000175:diagnosis / Q000188:drug therapy; D022641:Shiga Toxin 2 / Q000235:genetics; D054323:Shiga-Toxigenic Escherichia coli / Q000235:genetics / Q000302:isolation & purification* / Q000472:pathogenicity
chemical_list: D000927:Anticonvulsants; D022641:Shiga Toxin 2; C450841:shiga toxin 2 B subunit