title: Importance of adjusting dual-energy X-ray output for body size: an example from survivors of childhood acute lymphoblastic leukemia.
abstract: We compared DXA whole body and lumbar spine bone mineral density (BMD) using manufacturers software with a body size correction which derived bone mineral content (BMC) for bone area in survivors of acute lymphoblastic leukemia in Saudi Arabia (n = 51, mean age 13.5 y). With no corrections, 29 patients (57%) had lumbar spine BMD Z score < -1.0 and 21 (41%) had whole body BMD Z score < -2. After correction, only 6 (12%) had lumbar spine BMC Z score < -1.0 and 4 (8%) had whole body BMC Z score < -2. Agreement between the methods was "poor" by weighted κ analysis.
authors.affiliation: College of Medical, Veterinary, and Life Sciences, University of Glasgow, Glasgow, Scotland.
authors.forename: Fahad
authors.initials: F
authors.lastname: Aldhafiri
authors.forename: Abdallah
authors.initials: A
authors.lastname: Al-Nasser
authors.forename: Abdulaziz
authors.initials: A
authors.lastname: Al-Sugair
authors.forename: Sheila
authors.initials: S
authors.lastname: Khanna
authors.forename: Faisal S
authors.initials: FS
authors.lastname: Ahmed
authors.forename: Hanan
authors.initials: H
authors.lastname: Al-Mutairi
authors.forename: John J
authors.initials: JJ
authors.lastname: Reilly
mesh_terms: D015502:Absorptiometry, Photon; D000293:Adolescent; D049628:Body Size; D015519:Bone Density; D005260:Female; D006801:Humans; D008297:Male; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000000981:diagnostic imaging*; D011379:Prognosis; D012529:Saudi Arabia; D017741:Survivors