title: Treatment of candidiasis: insights from host genetics.
abstract: Candida species are major causes of mucosal and invasive infections, leading to substantial morbidity and mortality. Despite the development of new classes of antifungal drugs, mortality in patients with systemic candidiasis remains high. Host-Candida interaction plays an important role in effective elimination of the pathogen. Genetic studies have rendered important insights into antifungal host defense and have identified potential targets for adjunctive therapy. In this article, the authors review the genetic variations in the host defense to Candida and their implications for the treatment of mucosal and systemic candidiasis.
authors.affiliation: Department of Internal Medicine, Radboud University Nijmegen MedicalCenter, P O Box 9101, 6500HB Nijmegen, The Netherlands. c.delsing@aig.umcn.nl
authors.forename: Corine E
authors.initials: CE
authors.lastname: Delsing
authors.forename: Chantal P
authors.initials: CP
authors.lastname: Bleeker-Rovers
authors.forename: Bart-Jan
authors.initials: BJ
authors.lastname: Kullberg
authors.forename: Mihai G
authors.initials: MG
authors.lastname: Netea
mesh_terms: D000935:Antifungal Agents / Q000627:therapeutic use*; D053468:CARD Signaling Adaptor Proteins / Q000276:immunology; D002175:Candida / Q000276:immunology / Q000472:pathogenicity*; D002177:Candidiasis / Q000188:drug therapy* / Q000235:genetics* / Q000276:immunology / Q000382:microbiology; D016207:Cytokines / Q000276:immunology; D004198:Disease Susceptibility / Q000276:immunology / Q000382:microbiology; D020022:Genetic Predisposition to Disease; D014644:Genetic Variation; D006105:Granulomatous Disease, Chronic / Q000235:genetics / Q000382:microbiology; D054884:Host-Pathogen Interactions; D006801:Humans; D037181:Lectins, C-Type / Q000276:immunology; D037241:Mannose-Binding Lectins / Q000276:immunology; D051193:Toll-Like Receptors / Q000276:immunology; D000099181:Dectin-1
chemical_list: D000935:Antifungal Agents; D053468:CARD Signaling Adaptor Proteins; D016207:Cytokines; D037181:Lectins, C-Type; D037241:Mannose-Binding Lectins; D051193:Toll-Like Receptors; C505855:CARD9 protein, human; C546929:CLEC7A protein, human; D000099181:Dectin-1