title: Blends of cross-linked high amylose starch/pectin loaded with diclofenac.
abstract: Polymers blends represent an important approach to obtain materials with modulated properties to reach different and desired properties in designing drug delivery systems in order to fulfill therapeutic needs. The aim of this work was to evaluate the influence of drug loading and polymer ratio on the physicochemical properties of microparticles of cross-linked high amylose starch-pectin blends loaded with diclofenac for further application in controlled drug delivery systems. Thermal analysis and X-ray diffractograms evidenced the occurrence of drug-polymer interactions and the former pointed also to an increase in thermal stability due to drug loading. The rheological properties demonstrated that drug loading resulted in formation of weaker gels while the increase of pectin ratio contributes to origin stronger structures.
authors.affiliation: Faculdade de Ciências Farmacêuticas, Departamento de Fármacos e Medicamentos, Universidade Estadual Paulista - UNESP, Rodovia Araraquara-Jaú, km 1, CEP 14801-902, Araraquara, SP, Brazil.
authors.forename: Grazielle Arantes
authors.initials: GA
authors.lastname: Soares
authors.forename: Ana Dóris
authors.initials: AD
authors.lastname: de Castro
authors.forename: Beatriz S F
authors.initials: BS
authors.lastname: Cury
authors.forename: Raul C
authors.initials: RC
authors.lastname: Evangelista
mesh_terms: D000688:Amylose / Q000737:chemistry*; D004008:Diclofenac / Q000737:chemistry*; D004337:Drug Carriers / Q000737:chemistry*; D008863:Microspheres; D010316:Particle Size; D010368:Pectins / Q000737:chemistry*; D012212:Rheology; D013696:Temperature
chemical_list: D004337:Drug Carriers; D004008:Diclofenac; D010368:Pectins; D000688:Amylose