title: Accurate model-based reconstruction algorithm for three-dimensional optoacoustic tomography.
abstract: In many practical optoacoustic imaging implementations, dimensionality of the tomographic problem is commonly reduced into two dimensions or 1-D scanning geometries in order to simplify technical implementation, improve imaging speed or increase signal-to-noise ratio. However, this usually comes at a cost of significantly reduced quality of the tomographic data, out-of-plane image artifacts, and overall loss of image contrast and spatial resolution. Quantitative optoacoustic image reconstruction implies therefore collection of point 3-D (volumetric) data from as many locations around the object as possible. Here, we propose and validate an accurate model-based inversion algorithm for 3-D optoacoustic image reconstruction. Superior performance versus commonly-used backprojection inversion algorithms is showcased by numerical simulations and phantom experiments.
authors.affiliation: Institute for Biological and Medical Imaging, Technical University of Munich and Helmholtz Center Munich, Neuherberg, Germany.
authors.forename: X Luís
authors.initials: XL
authors.lastname: Deán-Ben
authors.forename: Andreas
authors.initials: A
authors.lastname: Buehler
authors.forename: Vasilis
authors.initials: V
authors.lastname: Ntziachristos
authors.forename: Daniel
authors.initials: D
authors.lastname: Razansky
mesh_terms: D000465:Algorithms; D000818:Animals; D003198:Computer Simulation; D006321:Heart / Q000033:anatomy & histology; D021621:Imaging, Three-Dimensional / Q000379:methods*; D051379:Mice; D008962:Models, Theoretical; D019047:Phantoms, Imaging; D061088:Photoacoustic Techniques / Q000379:methods*; D014054:Tomography / Q000379:methods*