title: Haematological and biochemical alterations caused by epidural and intramuscular administration of xylazine hydrochloride in dromedary camels (Camelus dromedarius).
abstract: This study was conducted in 16 healthy immature dromedary camels weighing 120-150 kg to evaluate and compare the effects of epidural and intramuscular injections of xylazine administered at 0.1 mg/kg and 0.2 mg/kg. Haematological parameters included haemoglobin, packed cell volume, total erythrocyte count and total leukocyte count. Biochemical parameters included alkaline phosphates, alanine aminotransferase, aspartate aminotransferase, blood urea nitrogen, creatinine and glucose. Parameters were measured at different intervals before (baseline) and after the administration of drugs. Our study showed that the effect of xylazine on haematological and biochemical parameters is dose-dependant and is also related to the route of administration. The low dose of xylazine administered using both intramuscular and epidural methods showed minimal effects, whereas high doses of the drug, especially when injected intramuscularly, caused greater changes in haematological and biochemical parameters.
authors.affiliation: Department of Clinical Sciences, Faculty of Veterinary Medicine, Shahid Bahonar University of Kerman, Kerman, Iran. omidazari@mail.uk.ac.ir
authors.forename: Omid
authors.initials: O
authors.lastname: Azari
authors.forename: Mohammad Mahdi
authors.initials: MM
authors.lastname: Molaei
authors.forename: Ladan
authors.initials: L
authors.lastname: Emadi
authors.forename: Ehsanollah
authors.initials: E
authors.lastname: Sakhaee
authors.forename: Hamid
authors.initials: H
authors.lastname: Sharifi
authors.forename: Sara
authors.initials: S
authors.lastname: Mehdizadeh
mesh_terms: D000818:Animals; D001772:Blood Cell Count; D002162:Camelus / Q000097:blood*; D004305:Dose-Response Relationship, Drug; D006454:Hemoglobins / Q000032:analysis*; D007273:Injections, Intramuscular; D007278:Injections, Spinal; D014991:Xylazine / Q000008:administration & dosage / Q000494:pharmacology*
chemical_list: D006454:Hemoglobins; D014991:Xylazine