title: Direct laser trapping for measuring the behavior of transfused erythrocytes in a sickle cell anemia patient.
abstract: Using a laser trap, we have studied the properties of erythrocytes from a sickle cell anemia patient (SCA) after receiving an intravenous blood transfusion, and a normal adult individual carrying normal adult hemoglobin. The hemoglobin type and quantitation assessment was carried out by high performance liquid chromatography (HPLC). We conducted an analysis of the size distributions of the cells. By targeting those erythrocytes in the overlapping regions of size distributions, we have investigated their properties when the cells are trapped and released. The efficacy of the transfusion treatment is also studied by comparing the relative changes in deformation and the relaxation-time of the cells in the two samples.
authors.affiliation: Department of Biology, Middle Tennessee State University, Murfreesboro, Tennessee, 37132,  USA.
authors.forename: Aline
authors.initials: A
authors.lastname: Pellizzaro
authors.forename: Gabriel
authors.initials: G
authors.lastname: Welker
authors.forename: David
authors.initials: D
authors.lastname: Scott
authors.forename: Rance
authors.initials: R
authors.lastname: Solomon
authors.forename: James
authors.initials: J
authors.lastname: Cooper
authors.forename: Anthony
authors.initials: A
authors.lastname: Farone
authors.forename: Mary
authors.initials: M
authors.lastname: Farone
authors.forename: Robert S
authors.initials: RS
authors.lastname: Mushi
authors.forename: Maria Del Pilar
authors.initials: Mdel P
authors.lastname: Aguinaga
authors.forename: Daniel
authors.initials: D
authors.lastname: Erenso