title: Recent advances in the comprehension and the management of perioperative systemic host response during cardiopulmonary bypass.
abstract: Cardiac surgery with cardiopulmonary induces a systemic inflammatory response (SIRS). SIRS is broadly defined as an inflammatory state of the whole body without a proven source of infection. Many pre and postoperative variables have been defined that have a negative impact on SIRS. Although many strategies have been developed, targeting given biomarkers very few of these proved to be effective in a clinical setting. In order to better understand why this happened a new approach for defining SIRS was proposed. This review describes this new concept and the recent patents involved.
authors.affiliation: University Hospital Gent, Heart Centre 5E-K12, De Pintelaan 185, B-9000 Gent, Belgium. Filip.DeSomer@UGent.be
authors.forename: Filip
authors.initials: F
authors.lastname: De Somer
mesh_terms: D015415:Biomarkers / Q000378:metabolism; D002315:Cardiopulmonary Bypass / Q000009:adverse effects / Q000379:methods*; D006801:Humans; D019990:Perioperative Care / Q000379:methods; D018746:Systemic Inflammatory Response Syndrome / Q000175:diagnosis* / Q000378:metabolism / Q000517:prevention & control*
chemical_list: D015415:Biomarkers