title: Regression of Hodgkin lymphoma in response to antiviral therapy for hepatitis C virus infection.
abstract: Links between hepatitis C virus (HCV) infection and several non-Hodgkin lymphomas have been suggested by epidemiological studies. We herein report the first documented case of a patient with HCV-associated Hodgkin lymphoma who showed a marked regression following interferon-based antiviral therapy. This unique case extends the spectrum of HCV-associated malignant lymphomas, confirms the efficacy of antiviral therapy for this rare extrahepatic manifestation and provides valuable clues for achieving a better understanding of lymphomagenesis in HCV.
authors.affiliation: Department of Gastroenterology and Hepatology, Graduate School of Medicine, Kyoto University, Japan. takaken@kuhp.kyoto-u.ac.jp
authors.forename: Ken
authors.initials: K
authors.lastname: Takahashi
authors.forename: Naoshi
authors.initials: N
authors.lastname: Nishida
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Kawabata
authors.forename: Hironori
authors.initials: H
authors.lastname: Haga
authors.forename: Tsutomu
authors.initials: T
authors.lastname: Chiba
mesh_terms: D000998:Antiviral Agents / Q000627:therapeutic use*; D019698:Hepatitis C, Chronic / Q000150:complications* / Q000188:drug therapy*; D006689:Hodgkin Disease / Q000150:complications* / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000473:pathology; D006801:Humans; D016898:Interferon-alpha / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D011092:Polyethylene Glycols / Q000627:therapeutic use; D011994:Recombinant Proteins / Q000627:therapeutic use; D012074:Remission Induction; D012254:Ribavirin / Q000627:therapeutic use; D014057:Tomography, X-Ray Computed
chemical_list: D000998:Antiviral Agents; D016898:Interferon-alpha; D011994:Recombinant Proteins; D011092:Polyethylene Glycols; D012254:Ribavirin; C100416:peginterferon alfa-2a