title: Protective effects of amlodipine on mitochondrial injury in ischemic reperfused rat heart.
abstract: The most significant finding of the present study was the release of nitric oxide (NO). The effect of amlodipine on NO production associated with ischemic reperfused (IR) injury was investigated in rat heart model. Cardiac tissues from animal groups were processed for biochemical, histopathological and electron microscopic studies. There was a significant increase in myocardial catalase (CAT), superoxide dismutase (SOD) and glutathione (GSH) enzymes in amlodipine treated group (1.37, 10.27, 6.39) when compared to IR injured group (0.81, 6.87, 4.53). Histopathology studies showed amlodipine reduce cardiocyte damage in cardiac injury during the cardiac IR. Transmission electron microscopic (TEM) study confirmed the cardioprotective role of amlodipine against IR induced cardiac injury. On the basis of findings, it is hypothesized that a portion of the beneficial actions of amlodipine may involve the release or action of NO and probably by its antioxidant properties.
authors.affiliation: Department of Pharmacology and Clinical Research, College of Pharmacy, IFTM University, Moradabad - 244 001, India. alikhan_najam@yahoo.co.in
authors.forename: Najam Ali
authors.initials: NA
authors.lastname: Khan
authors.forename: Pronobesh
authors.initials: P
authors.lastname: Chattopadhyay
authors.forename: Mohammad
authors.initials: M
authors.lastname: Abid
authors.forename: Abhijeet
authors.initials: A
authors.lastname: Pawdey
authors.forename: Kamal
authors.initials: K
authors.lastname: Kishore
authors.forename: Arun Kumar
authors.initials: AK
authors.lastname: Wahi
mesh_terms: D017311:Amlodipine / Q000494:pharmacology / Q000627:therapeutic use*; D000818:Animals; D002121:Calcium Channel Blockers / Q000494:pharmacology / Q000627:therapeutic use*; D003331:Coronary Vessels / Q000187:drug effects; D005260:Female; D008297:Male; D008929:Mitochondria, Heart / Q000187:drug effects* / Q000201:enzymology; D015428:Myocardial Reperfusion Injury / Q000517:prevention & control*; D009569:Nitric Oxide / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar; D014664:Vasodilation / Q000187:drug effects
chemical_list: D002121:Calcium Channel Blockers; D017311:Amlodipine; D009569:Nitric Oxide