title: Rotavirus genotypes in Malaysia and universal rotavirus vaccination.
abstract: Group A rotavirus (RV-A) genotypes isolated in Malaysia was studied to estimate the effectiveness of a universal RV-A vaccination in Malaysia. A simple mathematical model was used, with input from a two-year, two-center, prospective study on hospitalization of RV-A gastroenteritis (RVGE) in young children, published data on RV-A hospitalizations and genotypes, mortality on childhood GE and published genotype-specific efficacy data on two RV-A vaccines. Assuming a 95% vaccine coverage, the overall projected effectiveness was 75.7 to 88.1% for Rotateq and 78.7 to 90.6% for Rotarix® against RVGE-related hospitalizations. The projected annual reduction in RVGE-related deaths was 27 to 32 deaths (from 34 deaths) for Rotateq and 28 to 32 deaths annually for Rotarix. A universal RV-A vaccine is efficacious in reducing RVGE-related hospitalizations and mortality in Malaysia.
authors.affiliation: Department of Paediatrics, University of Malaya Medical Centre, Kuala Lumpur, Malaysia. leews@um.edu.my
authors.forename: Way Seah
authors.initials: WS
authors.lastname: Lee
authors.forename: Benjamin Tze Ying
authors.initials: BT
authors.lastname: Lim
authors.forename: Pei Fan
authors.initials: PF
authors.lastname: Chai
authors.forename: Carl D
authors.initials: CD
authors.lastname: Kirkwood
authors.forename: Jimmy Kok Foo
authors.initials: JK
authors.lastname: Lee
mesh_terms: D002675:Child, Preschool; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008296:Malaysia / Q000453:epidemiology; D008297:Male; D008962:Models, Theoretical; D012401:Rotavirus / Q000145:classification / Q000235:genetics* / Q000472:pathogenicity*; D012400:Rotavirus Infections / Q000453:epidemiology / Q000517:prevention & control*; D022243:Rotavirus Vaccines / Q000627:therapeutic use*; D014611:Vaccination / Q000706:statistics & numerical data
chemical_list: D022243:Rotavirus Vaccines