title: Impact of wheel running on chronic ethanol intake in aged Syrian hamsters.
abstract: BACKGROUND
  Alcohol dependence in aging populations is seen as a public health concern, most recently because of the significant proportion of heavy drinking among "Baby Boomers." Basic animal research on the effects of aging on physiological and behavioral regulation of ethanol (EtOH) intake is sparse, since most of this research is limited to younger models of alcoholism. Here, EtOH drinking and preference were measured in groups of aged Syrian hamsters. Further, because voluntary exercise (wheel-running) is a rewarding substitute for EtOH in young adult hamsters, the potential for such reward substitution was also assessed.
  
  
  METHODS
  Aged (24 month-old) male hamsters were subjected to a three-stage regimen of free-choice EtOH (20% v/v) or water and unlocked or locked running wheels to investigate the modulatory effects of voluntary wheel running on EtOH intake and preference. Levels of fluid intake and activity were recorded daily across 60 days of experimentation.
  
  
  RESULTS
  Prior to wheel running, levels of EtOH intake were significantly less than levels of water intake, resulting in a low preference for EtOH (30%). Hamsters with access to an unlocked running wheel had decreased EtOH intake and preference compared with hamsters with access to a locked running wheel. These group differences in EtOH intake and preference were sustained for up to 10 days after running wheels were re-locked.
  
  
  CONCLUSIONS
  These results extend upon those of our previous work in young adult hamsters, indicating that aging dampens EtOH intake and preference. Voluntary wheel running further limited EtOH intake, suggesting that exercise could offer a practical approach for managing late-life alcoholism.
authors.affiliation: Department of Neurobiology, Morehouse School of Medicine, Atlanta, GA 30310, United States. abrager@msm.edu
authors.forename: Allison J
authors.initials: AJ
authors.lastname: Brager
authors.forename: Steven B
authors.initials: SB
authors.lastname: Hammer
mesh_terms: D000375:Aging / Q000187:drug effects / Q000502:physiology*; D000428:Alcohol Drinking / Q000503:physiopathology / Q000523:psychology; D000704:Analysis of Variance; D000818:Animals; D002492:Central Nervous System Depressants / Q000008:administration & dosage / Q000378:metabolism*; D002755:Choice Behavior; D006224:Cricetinae; D000431:Ethanol / Q000008:administration & dosage / Q000378:metabolism*; D005518:Food Preferences; D008297:Male; D008647:Mesocricetus / Q000502:physiology*; D009043:Motor Activity / Q000187:drug effects / Q000502:physiology*; D010805:Physical Conditioning, Animal; D012201:Reward; D013997:Time Factors
chemical_list: D002492:Central Nervous System Depressants; D000431:Ethanol