title: Comparison of a biodegradable ureteral stent versus the traditional double-J stent for the treatment of ureteral injury: an experimental study.
abstract: Ureteral injury remains a major clinical problem; here we developed a biodegradable ureteral stent and compared its effectiveness with a double-J stent for treating ureteral injury. Eighteen dogs with injured ureters were subdivided into two groups. In group A, one injured ureter was treated with a biodegradable stent, whereas only end-to-end anastomosis was performed on the other side. In group B, one injured ureter was treated with a biodegradable stent, while a double-J stent was used on the other side. Intravenous urography, radioactive renography, histological examinations, scanning electron microscopy (SEM) and elemental composition analysis were performed at 40, 80 and 120 days postoperatively. Results showed that the biodegradable stent could effectively prevent hydronephrosis and hydroureter secondary to ureteral injury. Moreover all biodegradable stents gradually degraded and discharged completely in 120 days. SEM and elemental composition analysis of the surface of the double-J stent confirmed calcification at 80 days and calcific plaque at 120 days, while no signs of calcification were found in the biodegradable stent group. Histological studies found no difference between the biodegradable stented ureters and double-J stented ureters. It is concluded that the biodegradable ureteral stent was more advantageous than the double-J stent for treating ureteral injury in a canine model.
authors.affiliation: Department of Urology, Chinese People's Liberation Army General Hospital, Military Postgraduate Medical College, No 28 Fuxing Road, Hai dian District, Beijing 100853, People's Republic of China. fuweijun@hotmail.com
authors.forename: Wei-Jun
authors.initials: WJ
authors.lastname: Fu
authors.forename: Zhong-Xin
authors.initials: ZX
authors.lastname: Wang
authors.forename: Gang
authors.initials: G
authors.lastname: Li
authors.forename: Fu-Zhai
authors.initials: FZ
authors.lastname: Cui
authors.forename: Yuanyuan
authors.initials: Y
authors.lastname: Zhang
authors.forename: Xu
authors.initials: X
authors.lastname: Zhang
mesh_terms: D020341:Absorbable Implants; D000818:Animals; D004867:Equipment Design; D005260:Female; D007668:Kidney / Q000473:pathology; D019344:Lactic Acid / Q000737:chemistry; D008297:Male; D008422:Materials Testing; D008855:Microscopy, Electron, Scanning / Q000379:methods; D011091:Polyesters; D011108:Polymers / Q000737:chemistry; D011183:Postoperative Complications; D011866:Radioisotope Renography / Q000379:methods; D015607:Stents; D013499:Surface Properties; D013997:Time Factors; D014513:Ureter / Q000293:injuries* / Q000473:pathology*; D014567:Urography / Q000379:methods
chemical_list: D011091:Polyesters; D011108:Polymers; D019344:Lactic Acid; C033616:poly(lactide)