title: Tumor vascular responses to antivascular and antiangiogenic strategies: looking for suitable models.
abstract: Antiangiogenic and vascular disrupting agents are in the current cancer therapeutic armamentarium. A better understanding of the intricate mechanisms ruling neovessel survival within tumors during or after treatment is needed. Refinement of imaging and a growing knowledge of molecular biology of tumor vascularization provide new insights. It is necessary to define suitable methods for monitoring tumor response and appropriate tools to analyze data. This review compares most commonly used preclinical models, considering their recent improvements, and describes promising new approaches such as microfluidics, real-time electrical impedance based technique and noninvasive imaging techniques. The advantages and limitations of the in vitro, ex vivo and in vivo models are discussed. This review also provides a critical summary of emerging approaches using mathematical modeling.
authors.affiliation: Université de Lorraine, CRAN, UMR 7039, Vandœuvre-lès-Nancy, France.
authors.forename: Jihane
authors.initials: J
authors.lastname: Mriouah
authors.forename: Cédric
authors.initials: C
authors.lastname: Boura
authors.forename: Magalie
authors.initials: M
authors.lastname: Thomassin
authors.forename: Thierry
authors.initials: T
authors.lastname: Bastogne
authors.forename: Dominique
authors.initials: D
authors.lastname: Dumas
authors.forename: Béatrice
authors.initials: B
authors.lastname: Faivre
authors.forename: Muriel
authors.initials: M
authors.lastname: Barberi-Heyob
mesh_terms: D020533:Angiogenesis Inhibitors / Q000494:pharmacology*; D000818:Animals; D003198:Computer Simulation; D006801:Humans; D008954:Models, Biological; D009369:Neoplasms / Q000098:blood supply* / Q000188:drug therapy*; D009389:Neovascularization, Pathologic / Q000188:drug therapy
chemical_list: D020533:Angiogenesis Inhibitors