title: HIF-1 expression in retinal ganglion cells and optic nerve axons in glaucoma.
abstract: Glaucoma is a result of increased intraocular pressure leading to damage to retinal ganglion cells and optic nerve axons. The aim of this study was to evaluate HIF-1 expression in optic nerve axons and retinal ganglion cells in 42 eyes enucleated because of complete glaucoma compared to eyes removed because of injury.The immunohistochemical reaction was done and specimens were examined under a light microscope. 57% of cases presented HIF-1 expression in the optic nerve axons, and 52.3% in the retinal ganglion cells. 20 out of 42(47.6%) cases were HIF-1 positive both in the optic nerve axons and in the retinal ganglion cells, and the staining was evident mostly in the nuclear and perinuclear area. Our present results indicate that HIF-1 expression in hypoxic conditions in glaucoma might be a very crucial stage in damage to retinal ganglion cells and optic nerve axons, and might be a successful target for the implementation of neuroprotective drugs.
authors.affiliation: Department of Medical Pathomorphology, Medical University of Bialystok, Poland. joasia@umb.edu.pl
authors.forename: Joanna
authors.initials: J
authors.lastname: Reszeć
authors.forename: Renata
authors.initials: R
authors.lastname: Zalewska
authors.forename: Piotr
authors.initials: P
authors.lastname: Bernaczyk
authors.forename: Lech
authors.initials: L
authors.lastname: Chyczewski
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001369:Axons / Q000378:metabolism* / Q000473:pathology; D005260:Female; D005901:Glaucoma / Q000378:metabolism* / Q000473:pathology*; D006801:Humans; D051795:Hypoxia-Inducible Factor 1, alpha Subunit / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D009900:Optic Nerve / Q000378:metabolism* / Q000473:pathology; D012165:Retinal Ganglion Cells / Q000378:metabolism* / Q000473:pathology*; D055815:Young Adult
chemical_list: C497442:HIF1A protein, human; D051795:Hypoxia-Inducible Factor 1, alpha Subunit