title: Sexual transmission of predicted CXCR4-tropic HIV-1 likely originating from the source partner's seminal cells.
abstract: We present a case of sexual transmission of HIV-1 predicted to have CXCR4-tropism during male-to-male sexual exposure. Phylogenetic analyses exclude cell-free virus in the seminal plasma of the source partner and possibly point to the seminal cells as the origin of the transmission event.
authors.affiliation: University of California San Diego, La Jolla, CA 92093-0679, USA. gianella@ucsd.edu
authors.forename: Sara
authors.initials: S
authors.lastname: Gianella
authors.forename: Sanjay R
authors.initials: SR
authors.lastname: Mehta
authors.forename: Jason A
authors.initials: JA
authors.lastname: Young
authors.forename: Milenka V
authors.initials: MV
authors.lastname: Vargas
authors.forename: Susan J
authors.initials: SJ
authors.lastname: Little
authors.forename: Douglas D
authors.initials: DD
authors.lastname: Richman
authors.forename: Sergei L
authors.initials: SL
authors.lastname: Kosakovsky Pond
authors.forename: Davey M
authors.initials: DM
authors.lastname: Smith
mesh_terms: D000328:Adult; D016000:Cluster Analysis; D015658:HIV Infections / Q000635:transmission*; D015497:HIV-1 / Q000235:genetics / Q000302:isolation & purification* / Q000472:pathogenicity*; D006801:Humans; D008297:Male; D008969:Molecular Sequence Data; D010802:Phylogeny; D012367:RNA, Viral / Q000235:genetics*; D019718:Receptors, CXCR4 / Q000378:metabolism; D015728:Receptors, HIV / Q000378:metabolism; D012661:Semen / Q000821:virology*; D017422:Sequence Analysis, DNA; D055815:Young Adult
chemical_list: C527276:CXCR4 protein, human; D012367:RNA, Viral; D019718:Receptors, CXCR4; D015728:Receptors, HIV