title: Mechanisms in endocrinology. Role of emotional stress in the pathophysiology of Graves' disease.
abstract: The role of stress in the pathophysiology of Graves' disease is suggested by several clinical observations, by recent advances in immunology and by better understanding of autoimmune diseases which provides new insights into potential effects of stress hormones on T helper cell imbalance involved in the pathogenesis of autoimmune diseases. Stress management should therefore be an important part of the treatment of Graves' disease, as stress reduction may improve the effect of therapy. However, this field still requires interventional data to support stress management in the treatment of Graves' disease.
authors.affiliation: Hôpitaux Universitaires Paris-Seine Saint-Denis, Bobigny Cedex, France.
authors.forename: Géraldine
authors.initials: G
authors.lastname: Falgarone
authors.forename: Hassan M
authors.initials: HM
authors.lastname: Heshmati
authors.forename: Régis
authors.initials: R
authors.lastname: Cohen
authors.forename: Gérard
authors.initials: G
authors.lastname: Reach
mesh_terms: D000328:Adult; D001327:Autoimmune Diseases / Q000276:immunology; D005260:Female; D005938:Glucocorticoids / Q000502:physiology; D007987:Gonadotropin-Releasing Hormone / Q000502:physiology; D006111:Graves Disease / Q000276:immunology / Q000503:physiopathology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D013315:Stress, Psychological / Q000150:complications*; D006377:T-Lymphocytes, Helper-Inducer / Q000473:pathology
chemical_list: D005938:Glucocorticoids; D007987:Gonadotropin-Releasing Hormone