title: The molecular basis of T cell acute lymphoblastic leukemia.
abstract: T cell acute lymphoblastic leukemias (T-ALLs) arise from the malignant transformation of hematopoietic progenitors primed toward T cell development, as result of a multistep oncogenic process involving constitutive activation of NOTCH signaling and genetic alterations in transcription factors, signaling oncogenes, and tumor suppressors. Notably, these genetic alterations define distinct molecular groups of T-ALL with specific gene expression signatures and clinicobiological features. This review summarizes recent advances in our understanding of the molecular genetics of T-ALL.
authors.affiliation: Institute for Cancer Genetics, Department of Pathology, Columbia University Medical Center, New York, New York 10032, USA.
authors.forename: Pieter
authors.initials: P
authors.lastname: Van Vlierberghe
authors.forename: Adolfo
authors.initials: A
authors.lastname: Ferrando
mesh_terms: D018797:Cell Cycle Proteins / Q000235:genetics / Q000502:physiology; D019070:Cell Lineage; D002471:Cell Transformation, Neoplastic / Q000235:genetics; D042002:Chromatin Assembly and Disassembly / Q000235:genetics / Q000502:physiology; D019941:Cyclin-Dependent Kinase Inhibitor p16 / Q000502:physiology; D019942:Genes, p16; D006412:Hematopoietic Stem Cells / Q000473:pathology; D018398:Homeodomain Proteins / Q000235:genetics / Q000502:physiology; D006801:Humans; D058990:Molecular Targeted Therapy; D009363:Neoplasm Proteins / Q000235:genetics / Q000502:physiology*; D054218:Precursor T-Cell Lymphoblastic Leukemia-Lymphoma / Q000145:classification / Q000209:etiology / Q000235:genetics*; D011379:Prognosis; D051880:Receptors, Notch / Q000502:physiology; D015398:Signal Transduction / Q000235:genetics / Q000502:physiology; D013601:T-Lymphocytes / Q000473:pathology; D014157:Transcription Factors / Q000502:physiology; D059467:Transcriptome; D025521:Tumor Suppressor Proteins / Q000235:genetics / Q000502:physiology
chemical_list: D018797:Cell Cycle Proteins; D019941:Cyclin-Dependent Kinase Inhibitor p16; D018398:Homeodomain Proteins; D009363:Neoplasm Proteins; D051880:Receptors, Notch; D014157:Transcription Factors; D025521:Tumor Suppressor Proteins