title: Methicillin-resistant Staphylococcus aureus sequence type 239-III, Ohio, USA, 2007-2009.
abstract: Methicillin-resistant Staphylococcus aureus (MRSA) is a human pathogen that has diverse molecular heterogeneity. Most MRSA strains in the United States are pulsed-field gel electrophoresis USA100 sequence type (ST) 5 and USA300 ST8. Infections with MRSA ST239-III are common and found during health care-associated outbreaks. However, this strain has been rarely reported in the United States. As part of a study supported by the Prevention Epicenter Program of the Centers for Disease Control and Prevention (Atlanta, GA, USA), which evaluated transmission of MRSA among hospitals in Ohio, molecular typing identified 78 (6%) of 1,286 patients with MRSA ST239-III infections. Ninety-five percent (74/78) of these infections were health care associated, and 65% (51/78) of patients had histories of invasive device use. The crude case-fatality rate was 22% (17/78). Identification of these strains, which belong to a virulent clonal group, emphasizes the need for molecular surveillance.
authors.affiliation: Ohio State University Wexner Medical Center, Columbus, Ohio 43210, USA. shu-hua.wang@osumc.edu
authors.forename: Shu-Hua
authors.initials: SH
authors.lastname: Wang
authors.forename: Yosef
authors.initials: Y
authors.lastname: Khan
authors.forename: Lisa
authors.initials: L
authors.lastname: Hines
authors.forename: José R
authors.initials: JR
authors.lastname: Mediavilla
authors.forename: Liangfen
authors.initials: L
authors.lastname: Zhang
authors.forename: Liang
authors.initials: L
authors.lastname: Chen
authors.forename: Armando
authors.initials: A
authors.lastname: Hoet
authors.forename: Tammy
authors.initials: T
authors.lastname: Bannerman
authors.forename: Preeti
authors.initials: P
authors.lastname: Pancholi
authors.forename: D Ashley
authors.initials: DA
authors.lastname: Robinson
authors.forename: Barry N
authors.initials: BN
authors.lastname: Kreiswirth
authors.forename: Kurt B
authors.initials: KB
authors.lastname: Stevenson
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000900:Anti-Bacterial Agents / Q000494:pharmacology; D015373:Bacterial Typing Techniques; D002404:Catheterization / Q000009:adverse effects; D003428:Cross Infection / Q000453:epidemiology* / Q000382:microbiology; D005260:Female; D005838:Genotype; D006801:Humans; D008297:Male; D055624:Methicillin-Resistant Staphylococcus aureus / Q000145:classification / Q000187:drug effects / Q000235:genetics*; D008826:Microbial Sensitivity Tests; D008875:Middle Aged; D058889:Molecular Typing; D009820:Ohio / Q000453:epidemiology; D006435:Renal Dialysis / Q000009:adverse effects; D012121:Respiration, Artificial / Q000009:adverse effects; D013203:Staphylococcal Infections / Q000453:epidemiology* / Q000382:microbiology; D055815:Young Adult
chemical_list: D000900:Anti-Bacterial Agents