title: [Effects of Xinjierkang on two kidney one clip-induced hypertension and target organ injury in rats].
abstract: OBJECTIVE
  To investigate the effects of Xinjierkang on two kidney one clip -induced hypertension and target organ injury in rats.
  
  
  METHODS
  Two kidney one clip-induced hypertension rats model was established. Rats were divided into control group, model group, Xinjierkang group, and fosinopril group. At the end of 8th w, the hemodynamics indexes were recorded. The cardiac hypertrophy index was expressed as heart weight/body weight (HW/BW), the histological changes of heart, aorta and kidney were investigated by HE and/or Van Gieson stain.
  
  
  RESULTS
  Compared with control group, the heart systolic and diastolic function were impaired, the heart weight index, cardiomyocytes cross section area (CSA), cardiac collagen deposition, vascular remodeling index and glomerulus area were increased markedly in model group rats. Administration of Xinjierkang and fosinopril markedly ameliorated hemodynamic indexes, inhibited the elevation of HW/BW ratio, CSA of cardiomyocytes, vascular remodeling index and glomerulus hypertrophy, decreased collagen deposition in heart.
  
  
  CONCLUSIONS
  Xinjierkang has protective effects against two kidney one clip-induced hemodynamic impairment, cardiovascular remodeling and glomerulus hypertrophy in rats.
authors.affiliation: Department of Pharmacology, College of Basic Medical, Anhui Medical University, Hefei 230032, China. aydgs@126.com
authors.forename: Shan
authors.initials: S
authors.lastname: Gao
authors.forename: Ling-Ling
authors.initials: LL
authors.lastname: Huang
authors.forename: Xing-Hui
authors.initials: XH
authors.lastname: Wang
authors.forename: Ting-Ting
authors.initials: TT
authors.lastname: Yu
authors.forename: Su-Ming
authors.initials: SM
authors.lastname: Du
authors.forename: Yan-Wei
authors.initials: YW
authors.lastname: Guo
mesh_terms: D000818:Animals; D000959:Antihypertensive Agents / Q000494:pharmacology* / Q000627:therapeutic use; D001794:Blood Pressure / Q000187:drug effects; D004195:Disease Models, Animal; D004338:Drug Combinations; D004365:Drugs, Chinese Herbal / Q000494:pharmacology* / Q000627:therapeutic use; D017328:Fosinopril / Q000494:pharmacology; D006339:Heart Rate / Q000187:drug effects; D006977:Hypertension, Renal / Q000150:complications / Q000188:drug therapy* / Q000473:pathology; D007678:Kidney Glomerulus / Q000187:drug effects / Q000473:pathology*; D008297:Male; D009206:Myocardium / Q000473:pathology*; D010946:Plants, Medicinal / Q000737:chemistry; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley; D012077:Renal Artery / Q000601:surgery; D016277:Ventricular Function, Left / Q000187:drug effects; D017725:Ventricular Pressure / Q000187:drug effects; D020257:Ventricular Remodeling / Q000187:drug effects*
chemical_list: D000959:Antihypertensive Agents; D004338:Drug Combinations; D004365:Drugs, Chinese Herbal; D017328:Fosinopril