title: Variable compliance with clinical practice guidelines identified in a 1-day audit at 66 French adult intensive care units.
abstract: OBJECTIVE
  Clinical guidelines should provide a framework for managing patients hospitalized in intensive care units. Little is known about guideline compliance in real-life practice. To evaluate compliance rates for a large bundle of intensive care unit practice guidelines and determine factors associated with noncompliance to these guidelines.
  
  
  METHODS
  A bundle of 13 clinical guidelines was elaborated by a group of senior physicians. Four external consultants validated the process. Then, a 1-day audit was performed at 66 participating adult intensive care units in 39 institutions by a group of 64 junior investigators supervised by senior intensivists. At the bedside, investigators collected data from 625 patients hospitalized in those units.
  
  
  METHODS
  The eligibility and compliance rates were determined for each clinical recommendation. The rate of full compliance to each eligible clinical guideline was calculated. Mortality data were requested 28 days after the completion of the audit.
  
  
  RESULTS
  The eligibility rate ranged from 11% (sepsis bundle) to 80% (identified closest relative). The median compliance rate was 75% (60-100), ranging from 24% (sedation monitoring) to 96% (identified closest relative and bacteriological sampling before initiating antibiotics). Our results showed that only 24% (20-27) of patients in our cohort received fully compliant care. The 28-day survival probability was .77 (.73-.80).
  
  
  CONCLUSIONS
  At the bedside, clinical guidelines are fully applied in 24% of patients. Our study underlines the need to both improve the process of implementation and become cognizant of excessive proliferation of clinical guidelines.
authors.affiliation: Service d'Anesthésie et de Réanimation, Hôpital Nord, Aix-Marseille Univ, Marseille, France. marc.leone@ap-hm.fr
authors.forename: Marc
authors.initials: M
authors.lastname: Leone
authors.forename: Benoit
authors.initials: B
authors.lastname: Ragonnet
authors.forename: Sandrine
authors.initials: S
authors.lastname: Alonso
authors.forename: Bernard
authors.initials: B
authors.lastname: Allaouchiche
authors.forename: Jean-Michel
authors.initials: JM
authors.lastname: Constantin
authors.forename: Samir
authors.initials: S
authors.lastname: Jaber
authors.forename: Claude
authors.initials: C
authors.lastname: Martin
authors.forename: Pascale
authors.initials: P
authors.lastname: Fabbro-Peray
authors.forename: Jean-Yves
authors.initials: JY
authors.lastname: Lefrant
mesh_terms: D000328:Adult; D003695:Delivery of Health Care / Q000592:standards*; D019317:Evidence-Based Medicine; D005260:Female; D005602:France; D019983:Guideline Adherence / Q000706:statistics & numerical data*; D006801:Humans; D007362:Intensive Care Units; D008297:Male; D008485:Medical Audit; D017410:Practice Guidelines as Topic