title: Genomics of sex determination in Drosophila.
abstract: Drosophilists have identified many, or perhaps most, of the key regulatory genes determining sex using classical genetics, however, regulatory genes must ultimately result in the deployment of the genome in a quantitative manner, replete with complex interactions with other regulatory pathways. In the last decade, genomics has provided a rich picture of the transcriptional profile of the sexes that underlies sexual dimorphism. The current challenge is linking transcriptional profiles with the regulatory genes. This will be a complex synthesis, but the prospects for progress are outstanding.
authors.affiliation: Section of Developmental Genomics and Laboratory of Cellular and Developmental Biology, National Institute of Diabetes, and Digestive and Kidney Diseases, National Institutes of Health, Bethesda MD 20892-8028, USA. cloughea@mail.nih.gov
authors.forename: Emily
authors.initials: E
authors.lastname: Clough
authors.forename: Brian
authors.initials: B
authors.lastname: Oliver
mesh_terms: D000818:Animals; D004330:Drosophila / Q000235:genetics*; D049750:Genome, Insect; D023281:Genomics; D019849:Sex Determination Processes