title: Haplotypes in the CRP gene associated with increased BMI and levels of CRP in subjects with type 2 diabetes or obesity from Southwestern Mexico.
abstract: OBJECTIVE
  We evaluated the association between four polymorphisms in the CRP gene with circulating levels of C-reactive protein (CRP), type 2 diabetes (T2D), obesity, and risk score of coronary heart disease.
  
  
  METHODS
  We studied 402 individuals and classified them into four groups: healthy, obese, T2D obese, and T2D without obesity, from Guerrero, Southwestern Mexico. Blood levels of CRP, glucose, cholesterol, triglycerides, and leukocytes were measured. Genotyping was performed by PCR/RFLP, and the risk score for coronary heart disease was determined by the Framingham's methodology.
  
  
  RESULTS
  The TT genotype of SNP rs1130864 was associated with increased body mass index and T2D patients with obesity. We found that the haplotype 2 (TGAG) was associated with increased levels of CRP (β = 0.3; 95%CI: 0.1, 0.5; P = 0.005) and haplotype 7 (TGGG) with higher body mass index (BMI) (β = 0.2; 95%CI: 0.1, 0.3; P < 0.001). The risk score for coronary heart disease was associated with increased levels of CRP, but not with any polymorphism or haplotype.
  
  
  CONCLUSIONS
  The association between the TT genotype of SNP rs1130864 with obesity and the haplotype 7 with BMI may explain how obesity and genetic predisposition increase the risk of diseases such as T2D in the population of Southwestern Mexico.
authors.affiliation: Laboratorio de Enfermedades Crónico Degenerativas, Unidad Académica de Ciencias Químico Biológicas, Universidad Autónoma de Guerrero, 39070 Chilpancingo, GRO, Mexico.
authors.forename: América
authors.initials: A
authors.lastname: Martínez-Calleja
authors.forename: Irma
authors.initials: I
authors.lastname: Quiróz-Vargas
authors.forename: Isela
authors.initials: I
authors.lastname: Parra-Rojas
authors.forename: José Francisco
authors.initials: JF
authors.lastname: Muñoz-Valle
authors.forename: Marco A
authors.initials: MA
authors.lastname: Leyva-Vázquez
authors.forename: Gloria
authors.initials: G
authors.lastname: Fernández-Tilapa
authors.forename: Amalia
authors.initials: A
authors.lastname: Vences-Velázquez
authors.forename: Miguel
authors.initials: M
authors.lastname: Cruz
authors.forename: Eduardo
authors.initials: E
authors.lastname: Salazar-Martínez
authors.forename: Eugenia
authors.initials: E
authors.lastname: Flores-Alfaro
mesh_terms: D000328:Adult; D000368:Aged; D015992:Body Mass Index; D002097:C-Reactive Protein / Q000032:analysis / Q000235:genetics* / Q000378:metabolism; D003327:Coronary Disease / Q000453:epidemiology / Q000235:genetics; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000150:complications / Q000235:genetics* / Q000378:metabolism; D005260:Female; D005787:Gene Frequency; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006239:Haplotypes; D006801:Humans; D008297:Male; D008800:Mexico / Q000453:epidemiology; D008875:Middle Aged; D009765:Obesity / Q000097:blood / Q000150:complications / Q000235:genetics* / Q000378:metabolism; D056128:Obesity, Abdominal / Q000097:blood / Q000150:complications / Q000235:genetics / Q000378:metabolism; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors; D015430:Weight Gain
chemical_list: D002097:C-Reactive Protein