title: Effect of interpregnancy interval after a mifepristone-induced abortion on neonatal outcomes in subsequent pregnancy.
abstract: BACKGROUND
  The study evaluated effects of interpregnancy interval (IPI) on neonatal outcomes after mifepristone-induced abortion in the first pregnancy.
  
  
  METHODS
  This observational cohort study, conducted from 1998 to 2001 at antenatal clinics in Shanghai, Beijing, and Chengdu, China, included 4682 nulliparous women with one mifepristone-induced abortion in their first pregnancy, who were enrolled and followed up until delivery. We compared neonatal outcomes among women with different IPIs between their mifepristone-induced abortion and subsequent pregnancy.
  
  
  RESULTS
  When compared to IPI of 18-24 months, there was an increased risk of the neonate being small for gestational age (SGA) [adjusted odds ratio (aOR): 2.01; 95% confidence interval (CI): 1.04-3.88] when IPI was <6 months; this risk was greater among women without a curettage history after abortion (aOR: 2.49; 95% CI: 1.13-5.50). The associations between IPI and preterm delivery (<37 weeks), low birth weight (<2500 g), mean birth weight and ponderal index were not statistically significant.
  
  
  CONCLUSIONS
  The results indicate that an IPI <6 months after one mifepristone-induced abortion in first pregnancy is associated with an increased risk of SGA in the subsequent pregnancy.
authors.affiliation: Fudan University, Shanghai 200032, China.
authors.forename: Xiao-Xu
authors.initials: XX
authors.lastname: Huo
authors.forename: Er-Sheng
authors.initials: ES
authors.lastname: Gao
authors.forename: Yi-Min
authors.initials: YM
authors.lastname: Cheng
authors.forename: Lin
authors.initials: L
authors.lastname: Luo
authors.forename: Hong
authors.initials: H
authors.lastname: Liang
authors.forename: Guo-Ying
authors.initials: GY
authors.lastname: Huang
authors.forename: Mao-Hua
authors.initials: MH
authors.lastname: Miao
authors.forename: Wei
authors.initials: W
authors.lastname: Yuan
mesh_terms: D000021:Abortifacient Agents, Steroidal / Q000008:administration & dosage / Q000009:adverse effects*; D000028:Abortion, Induced / Q000009:adverse effects*; D000328:Adult; D001721:Birth Intervals; D002681:China / Q000453:epidemiology; D015331:Cohort Studies; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D007236:Infant, Small for Gestational Age; D015735:Mifepristone / Q000008:administration & dosage / Q000009:adverse effects*; D016017:Odds Ratio; D011247:Pregnancy; D047928:Premature Birth / Q000453:epidemiology*; D013997:Time Factors; D055815:Young Adult
chemical_list: D000021:Abortifacient Agents, Steroidal; D015735:Mifepristone