title: [Current trends in plasma transfusion for patients with severe hemorrhage].
abstract: Recent changes in plasma transfusion practices for severe hemorrhage are largely related to the recognition of an early endogenous coagulopathy associated with traumatic injury. Observational and mostly retrospective data suggest improved survival rates with high-dose plasma therapy, up to a 1:1 ratio of fresh frozen plasma to packed red blood cells, but the quality of evidence is limited. Putting it into practice raises many issues (early identification of patients at risk of massive bleeding, extrapolation to non-trauma settings, alternative or adjunctive treatments, among others) that are discussed in this brief review.
authors.affiliation: Département d'anesthésie-réanimation chirurgicale, pôle anesthésie-réanimations-soins intensifs-blocs opératoires-urgences, université de Bretagne Occidentale, hôpital de la Cavale-Blanche, CHRU de Brest, boulevard Tanguy-Prigent, 29609 Brest cedex, France. yves.ozier@chu-brest.fr
authors.forename: Y
authors.initials: Y
authors.lastname: Ozier
authors.forename: E
authors.initials: E
authors.lastname: Querellou
authors.forename: O
authors.initials: O
authors.lastname: Grimault
authors.forename: E
authors.initials: E
authors.lastname: L'Her
mesh_terms: D016913:Blood Component Transfusion; D006470:Hemorrhage / Q000628:therapy*; D006801:Humans; D010949:Plasma; D012720:Severity of Illness Index