title: Evaluation of dopamine transporters and D2 receptors in hemiparkinsonian rat brains in vivo using consecutive PET scans of [18F]FPCIT and [18F]fallypride.
abstract: The aim of this study was to investigate dopaminergic function in unilaterally lesioned 6-OHDA rats by dual PET radioligands: [(18)F]FPCIT (a dopamine transporter imaging radioligand) and [(18)F]fallypride (a dopamine D2 receptors imaging radioligand). As a result, the brain uptake of [(18)F]FPCIT was significantly reduced and that of [(18)F]fallypride was increased in the ipsilateral striatum (lesion side) of the 6-OHDA rats. These findings implicated that dopamine transporter is down-regulated and dopamine D2 receptor is up-regulated in this hemiparkinsonian rat model.
authors.affiliation: Department of Pharmacology, Brain Research Institute, Brain Korea 21 Project for Medical Science, Yonsei University College of Medicine, Seoul, Republic of Korea.
authors.forename: Jae Yong
authors.initials: JY
authors.lastname: Choi
authors.forename: Chul Hoon
authors.initials: CH
authors.lastname: Kim
authors.forename: Tae Joo
authors.initials: TJ
authors.lastname: Jeon
authors.forename: Won Gil
authors.initials: WG
authors.lastname: Cho
authors.forename: Jin Suk
authors.initials: JS
authors.lastname: Lee
authors.forename: Soo Jin
authors.initials: SJ
authors.lastname: Lee
authors.forename: Tae Hyun
authors.initials: TH
authors.lastname: Choi
authors.forename: Byoung Soo
authors.initials: BS
authors.lastname: Kim
authors.forename: Chi Hoon
authors.initials: CH
authors.lastname: Yi
authors.forename: Youngbeom
authors.initials: Y
authors.lastname: Seo
authors.forename: Dae Ik
authors.initials: DI
authors.lastname: Yi
authors.forename: Sang Jin
authors.initials: SJ
authors.lastname: Han
authors.forename: Minkyung
authors.initials: M
authors.lastname: Lee
authors.forename: Dong Goo
authors.initials: DG
authors.lastname: Kim
authors.forename: Jong Doo
authors.initials: JD
authors.lastname: Lee
authors.forename: Gwangil
authors.initials: G
authors.lastname: An
authors.forename: Young Hoon
authors.initials: YH
authors.lastname: Ryu
mesh_terms: D000818:Animals; D001549:Benzamides; D003342:Corpus Striatum / Q000000981:diagnostic imaging / Q000378:metabolism; D050483:Dopamine Plasma Membrane Transport Proteins / Q000378:metabolism*; D015536:Down-Regulation; D005462:Fluorine Radioisotopes; D008297:Male; D016627:Oxidopamine; D020734:Parkinsonian Disorders / Q000139:chemically induced / Q000503:physiopathology*; D049268:Positron-Emission Tomography / Q000379:methods; D051381:Rats; D017207:Rats, Sprague-Dawley; D017448:Receptors, Dopamine D2 / Q000378:metabolism*; D015899:Tomography, Emission-Computed, Single-Photon; D014326:Tropanes; D015854:Up-Regulation
chemical_list: D001549:Benzamides; D050483:Dopamine Plasma Membrane Transport Proteins; D005462:Fluorine Radioisotopes; D017448:Receptors, Dopamine D2; D014326:Tropanes; C087552:2-carbomethoxy-8-(3-fluoropropyl)-3-(4-iodophenyl)tropane; D016627:Oxidopamine; C574003:fallypride