title: HLA-E and HLA class I molecules on bone marrow and peripheral blood polymorphonuclear cells of myelodysplatic patients.
abstract: Relevance of immune-dysregulation for emergence, dominance and progression of dysplastic clones in myelodysplastic syndromes (MDS) was suggested, but valuable or predictive criteria on this involvement are lacking. We previously reported that reduced T-regulatory cells (Treg) and high CD54 expression on T cell identify a sub-group of patients in whom an immune-pathogenesis might be inferred. Here, we suggest the occurrence of immune-selection of dysplastic clones in a subgroup of MDS patients, with reduced HLA-I and HLA-E on PMN, and propose that an altered immune profile might represent a valuable criterion to classify Low/Int-1 patients on the basis of immune-pathogenesis of MDS.
authors.affiliation: Dipartimento di Scienze, Università della Basilicata, Potenza, Italy. terrazza@unina.it
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Terrazzano
authors.forename: Fiorella
authors.initials: F
authors.lastname: Alfinito
authors.forename: Anna Teresa
authors.initials: AT
authors.lastname: Palatucci
authors.forename: Valentina
authors.initials: V
authors.lastname: Rubino
authors.forename: Roberta
authors.initials: R
authors.lastname: Della Pepa
authors.forename: Angela
authors.initials: A
authors.lastname: Giovazzino
authors.forename: Giuseppina
authors.initials: G
authors.lastname: Ruggiero
mesh_terms: D001854:Bone Marrow Cells / Q000378:metabolism* / Q000473:pathology; D016022:Case-Control Studies; D015395:Histocompatibility Antigens Class I / Q000378:metabolism*; D006801:Humans; D016130:Immunophenotyping; D009190:Myelodysplastic Syndromes / Q000378:metabolism* / Q000473:pathology; D009504:Neutrophils / Q000378:metabolism* / Q000473:pathology; D000097625:HLA-E Antigens
chemical_list: D015395:Histocompatibility Antigens Class I; D000097625:HLA-E Antigens