title: Antimicrobials: Strategies for targeting obesity and metabolic health?
abstract: Obesity is associated with a number of serious health consequences, including type 2 diabetes, cardiovascular disease and a variety of cancers among others and has been repeatedly shown to be associated with a higher risk of mortality. The relatively recent discovery that the composition and metabolic activity of the gut microbiota may affect the risk of developing obesity and related disorders has led to an explosion of interest in this distinct research field. A corollary of these findings would suggest that modulation of gut microbial populations can have beneficial effects with respect to controlling obesity. In this addendum, we summarize our recent data, showing that therapeutic manipulation of the microbiota using different antimicrobial strategies may be a useful approach for the management of obesity and metabolic conditions. In addition, we will explore some of the mechanisms that may contribute to microbiota-induced susceptibility to obesity and metabolic diseases.
authors.affiliation: Alimentary Health Ltd., Cork, Ireland.
authors.forename: Eileen F
authors.initials: EF
authors.lastname: Murphy
authors.forename: Siobhan F
authors.initials: SF
authors.lastname: Clarke
authors.forename: Tatiana M
authors.initials: TM
authors.lastname: Marques
authors.forename: Colin
authors.initials: C
authors.lastname: Hill
authors.forename: Catherine
authors.initials: C
authors.lastname: Stanton
authors.forename: R Paul
authors.initials: RP
authors.lastname: Ross
authors.forename: Robert M
authors.initials: RM
authors.lastname: O'Doherty
authors.forename: Fergus
authors.initials: F
authors.lastname: Shanahan
authors.forename: Paul D
authors.initials: PD
authors.lastname: Cotter
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000008:administration & dosage*; D001419:Bacteria / Q000145:classification / Q000187:drug effects*; D004195:Disease Models, Animal; D041981:Gastrointestinal Tract / Q000382:microbiology*; D051379:Mice; D009765:Obesity / Q000382:microbiology / Q000517:prevention & control*
chemical_list: D000900:Anti-Bacterial Agents