title: Screening-level risk assessment for styrene-acrylonitrile (SAN) trimer detected in soil and groundwater.
abstract: A screening-level risk assessment was conducted for styrene-acrylonitrile (SAN) Trimer detected at the Reich Farm Superfund site in Toms River, NJ. Consistent with a screening-level approach, on-site and off-site exposure scenarios were evaluated using assumptions that are expected to overestimate actual exposures and hazards at the site. Environmental sampling data collected for soil and groundwater were used to estimate exposure point concentrations. Several exposure scenarios were evaluated to assess potential on-site and off-site exposures, using parameter values for exposures to soil (oral, inhalation of particulates, and dermal contact) and groundwater (oral, dermal contact) to reflect central tendency exposure (CTE) and reasonable maximum exposure (RME) conditions. Three reference dose (RfD) values were derived for SAN Trimer for short-term, subchronic, and chronic exposures, based upon its effects on the liver in exposed rats. Benchmark (BMD) methods were used to assess the relationship between exposure and response, and to characterize appropriate points of departure (POD) for each RfD. An uncertainty factor of 300 was applied to each POD to yield RfD values of 0.1, 0.04, and 0.03 mg/kg-d for short-term, subchronic, and chronic exposures, respectively. Because a chronic cancer bioassay for SAN Trimer in rats (NTP 2011a) does not provide evidence of carcinogenicity, a cancer risk assessment is not appropriate for this chemical. Potential health hazards to human health were assessed using a hazard index (HI) approach, which considers the ratio of exposure dose (i.e., average daily dose, mg/kg-d) to toxicity dose (RfD, mg/kg-d) for each scenario. All CTE and RME HI values are well below 1 (where the average daily dose is equivalent to the RfD), indicating that there is no concern for potential noncancer effects in exposed populations even under the conservative assumptions of this screening-level assessment.
authors.affiliation: Summit Toxicology, Orange Village, OH 44022, USA. ckirman@summittoxicology.com
authors.forename: C R
authors.initials: CR
authors.lastname: Kirman
authors.forename: M L
authors.initials: ML
authors.lastname: Gargas
authors.forename: J J
authors.initials: JJ
authors.lastname: Collins
authors.forename: J C
authors.initials: JC
authors.lastname: Rowlands
mesh_terms: D000181:Acrylonitrile / Q000032:analysis* / Q000633:toxicity; D000818:Animals; D004781:Environmental Exposure / Q000032:analysis; D004784:Environmental Monitoring / Q000379:methods; D060587:Groundwater / Q000032:analysis*; D006801:Humans; D051381:Rats; D018570:Risk Assessment; D012989:Soil Pollutants / Q000032:analysis* / Q000633:toxicity; D020058:Styrene / Q000032:analysis* / Q000633:toxicity; D014874:Water Pollutants, Chemical / Q000032:analysis* / Q000633:toxicity
chemical_list: D012989:Soil Pollutants; D014874:Water Pollutants, Chemical; D020058:Styrene; D000181:Acrylonitrile