title: Drug-associated thrombotic microangiopathies.
abstract: Thrombotic microangiopathy is a pathological process that results in thrombocytopenia, schistocytes, and organ ischemia. A wide variety of causes of thrombotic microangiopathy have been described, each associated with a different pathological stimulus and predisposition toward certain vascular territories. This review will summarize our understanding of key drugs that have been classically and newly associated with thrombotic microangiopathy as well as mention of treatment options focusing on the role of plasma exchange.
authors.affiliation: Division of Transfusion Medicine, Department of Laboratory Medicine & Pathology, Mayo Clinic, Rochester, Minnesota 55905, USA.
authors.forename: Justin
authors.initials: J
authors.lastname: Kreuter
authors.forename: Jeffrey L
authors.initials: JL
authors.lastname: Winters
mesh_terms: D064420:Drug-Related Side Effects and Adverse Reactions; D006801:Humans; D057049:Thrombotic Microangiopathies / Q000139:chemically induced* / Q000473:pathology