title: The clinical value of scintigraphy of neuroendocrine tumors using (99m)Tc-HYNIC-TOC.
abstract: OBJECTIVE
  To assess the value of whole body scintigraphy using (99m)Tc-HYNIC-TOC (Tektrotyd) and with single photon emission computerized tomography (SPECT) in the detection of primary and metastatic neuroendocrine tumors (NETs).
  
  
  METHODS
  Thirty patients with different neuroendocrine tumors, mainly gastroenteropancreatic (GEP), were investigated. Whole body scintigraphy was performed 2 h (if necessary 10 min and 24h) after i.v. administration of 740 Mbq (99m)Tc-Tektrotyd, Polatom. In cases of unclear findings obtained by whole body scintigraphy, investigation was followed by SPECT.
  
  
  RESULTS
  From 12 patients with NETs of unknown origin, there were 10 true positive (TP), and 2 false negative (FN) findings. Diagnosis was made with SPECT in 6 patients. From 8 patients with gut carcinoids, there were 4 TP, 2 true negative (TN), one FN, and one false positive (FP) finding. Diagnosis was made with SPECT in 2 patients. From 7 patients with neuroendocrine pancreatic carcinomas there were 4 TP and 3 TN findings. Diagnosis was made with SPECT in 2 patients. From 3 patients with gastrinomas there were 2 TP findings and one TN findings. Diagnosis was made with SPECT findings in 2 patients. Sensitivity of (99m)Tc-HYNIC-TOC was 87%, specificity 86%, positive predictive value 95%, negative predictive value 67% and accuracy 87%.
  
  
  CONCLUSIONS
  We concluded that scintigraphy with (99m)Tc-Tektrotyd is an useful method for diagnosis, staging and follow up of the patients with NETs.
authors.affiliation: Faculty of Medicine, University of Belgrade, Serbia. veraart@beotel.rs
authors.forename: V
authors.initials: V
authors.lastname: Artiko
authors.forename: D
authors.initials: D
authors.lastname: Sobic-Saranovic
authors.forename: S
authors.initials: S
authors.lastname: Pavlovic
authors.forename: M
authors.initials: M
authors.lastname: Petrovic
authors.forename: M
authors.initials: M
authors.lastname: Zuvela
authors.forename: A
authors.initials: A
authors.lastname: Antic
authors.forename: S
authors.initials: S
authors.lastname: Matic
authors.forename: S
authors.initials: S
authors.lastname: Odalovic
authors.forename: N
authors.initials: N
authors.lastname: Petrovic
authors.forename: A
authors.initials: A
authors.lastname: Milovanovic
authors.forename: V
authors.initials: V
authors.lastname: Obradovic
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D018358:Neuroendocrine Tumors / Q000000981:diagnostic imaging* / Q000473:pathology; D015282:Octreotide / Q000031:analogs & derivatives*; D015609:Organotechnetium Compounds; D015899:Tomography, Emission-Computed, Single-Photon / Q000379:methods*
chemical_list: D015609:Organotechnetium Compounds; C410263:technetium Tc 99m hydrazinonicotinyl-Tyr(3)-octreotide; D015282:Octreotide