title: CD20-positive and CD4/CD8-double-negative peripheral T-cell lymphoma of spleen complicated with severe disseminated intravascular coagulation and enteropathy.
abstract: A 71-year-old woman presented with massive splenomegaly. Open splenectomy was performed, and the diagnosis of peripheral T-cell lymphoma, not otherwise specified (PTCL-NOS), was made, with a characteristic immunophenotype of CD3(+), CD4(-), CD8(-), T-cell receptor (TCR)αβ(+), and TCRγδ(-). After splenectomy, she suffered abrupt exacerbation of the lymphoma with disseminated intravascular coagulation and enteropathy. Although chemotherapy was started, her medical condition did not improve and she died a week later. Postmortem reevaluation of the pathological specimen confirmed her diagnosis as CD20(+) PTCL-NOS. Although it is a rare disease entity, CD20(+) T-cell lymphoma can demonstrate aggressive clinical behavior.
authors.affiliation: Department of Hematology, Yamagata City Hospital Saiseikan, Yamagata, Japan. riviere13104@gmail.com
authors.forename: Satoshi
authors.initials: S
authors.lastname: Ichikawa
authors.forename: Shunsuke
authors.initials: S
authors.lastname: Hatta
authors.forename: Yo
authors.initials: Y
authors.lastname: Saito
authors.forename: Jun
authors.initials: J
authors.lastname: Kimura
authors.forename: Keisuke
authors.initials: K
authors.lastname: Onishi
authors.forename: Mikio
authors.initials: M
authors.lastname: Matsuda
authors.forename: Ryo
authors.initials: R
authors.lastname: Ichinohasama
authors.forename: Hideo
authors.initials: H
authors.lastname: Harigae
mesh_terms: D000208:Acute Disease; D000368:Aged; D018951:Antigens, CD20 / Q000235:genetics*; D015704:CD4 Antigens / Q000235:genetics; D016827:CD8 Antigens / Q000235:genetics; D004211:Disseminated Intravascular Coagulation / Q000150:complications / Q000276:immunology / Q000473:pathology*; D017809:Fatal Outcome; D005260:Female; D015870:Gene Expression; D006801:Humans; D007410:Intestinal Diseases / Q000150:complications / Q000276:immunology / Q000473:pathology*; D016411:Lymphoma, T-Cell, Peripheral / Q000150:complications / Q000276:immunology / Q000473:pathology*; D011948:Receptors, Antigen, T-Cell / Q000235:genetics; D013154:Spleen / Q000276:immunology / Q000473:pathology* / Q000601:surgery; D013156:Splenectomy; D013163:Splenomegaly / Q000150:complications / Q000276:immunology / Q000473:pathology / Q000601:surgery
chemical_list: D018951:Antigens, CD20; D015704:CD4 Antigens; D016827:CD8 Antigens; D011948:Receptors, Antigen, T-Cell