title: Hyperpnoeic response independent of limb movements at exercise onset in mice.
abstract: We have shown that constant-load treadmill exercise in mice produces an abrupt ventilatory increase to a maximal level at exercise onset. We examined what caused this abrupt response. We measured ventilation during 30-min constant-load exercise on a treadmill, below the lactate threshold, in conscious mice. Video analysis showed that hyperpnoea started before locomotion began. Incremental changes in speed did not further increase ventilation during the early phase of exercise. Next, we measured ventilatory responses to a sudden movement of the treadmill belt on which the mice were kept in a stationary position by a mesh cover. Hyperpnoea started concurrently with the sudden belt movement. In the absence of locomotion, ventilation increased to the extent reached during exercise hyperpnoea. Finally, the abrupt response showed plasticity but was attenuated by experience. The present study shows the importance of factors independent of limb movements in the hyperpnoeic response during the early phase of treadmill exercise in mice.
authors.affiliation: Department of Physiology, Showa University School of Medicine, 1-5-8 Hatanodai, Shinagawa-ku, Tokyo 142-8555, Japan. masahiko@med.showa-u.ac.jp
authors.forename: Masahiko
authors.initials: M
authors.lastname: Izumizaki
authors.forename: Michiko
authors.initials: M
authors.lastname: Iwase
authors.forename: Naoto
authors.initials: N
authors.lastname: Tsuchiya
authors.forename: Ikuo
authors.initials: I
authors.lastname: Homma
mesh_terms: D000818:Animals; D004558:Electric Stimulation; D005080:Exercise Test; D005121:Extremities / Q000502:physiology*; D006935:Hypercapnia / Q000503:physiopathology*; D019344:Lactic Acid / Q000097:blood; D008124:Locomotion; D051379:Mice; D008810:Mice, Inbred C57BL; D009068:Movement / Q000502:physiology*; D010101:Oxygen Consumption; D010805:Physical Conditioning, Animal / Q000502:physiology*; D011659:Pulmonary Gas Exchange; D012123:Pulmonary Ventilation / Q000502:physiology; D015656:Respiratory Mechanics; D018709:Statistics, Nonparametric; D013696:Temperature; D013997:Time Factors
chemical_list: D019344:Lactic Acid