title: Targeting chronic central nervous system HIV infection.
abstract: Central nervous system (CNS) HIV infection is a nearly universal facet of systemic infection. Although antiretroviral therapy is generally effective in suppressing this infection and reducing its severe complications, reports of continued neurological abnormalities have questioned whether treatment developed for systemic efficacy is optimized for CNS infection. Shikuma et al. report that a 'monocyte efficacy' score based on cell culture studies and applied to antiretroviral drugs correlated with neuropsychological performance in a previously reported cohort. Although there are important questions regarding the theoretical underpinnings of both this score and its application, the findings present a novel slant on therapy.
authors.affiliation: Department of Neurology, University of California San Francisco, San Francisco General Hospital, San Francisco, CA, USA. rwprice@sfgh.ucsf.edu
authors.forename: Richard W
authors.initials: RW
authors.lastname: Price
authors.forename: Ronald
authors.initials: R
authors.lastname: Swanstrom
mesh_terms: D003072:Cognition Disorders / Q000473:pathology*; D005260:Female; D015497:HIV-1 / Q000472:pathogenicity*; D006801:Humans; D008264:Macrophages / Q000187:drug effects*; D008297:Male; D009000:Monocytes / Q000187:drug effects*