title: Endovascular treatment of posterior communicating artery aneurysms with oculomotor nerve palsy: clinical outcomes and predictors of nerve recovery.
abstract: OBJECTIVE
  ONP is a well-known presentation of PcomA aneurysms. Reports on recovery of ONP with endovascular coiling have been limited to small case series. We assessed the safety and efficacy of endovascular therapy in a series of PcomA aneurysms with ONP.
  
  
  METHODS
  We reviewed 37 patients with ONP who underwent endovascular treatment in our institution between 2005 and 2011. Published studies were also reviewed to determine the overall rate of ONP recovery with endovascular therapy.
  
  
  RESULTS
  Nineteen patients (51.4%) presented with complete ONP, and 18 (48.6%), with partial ONP. Conventional coiling was performed in 31 (83.8%) patients; stent-assisted coiling, in 4 (10.8%); and balloon remodeling, in 2 (5.4%). There was 1 (2.7%) procedural complication (a transient thromboembolic event). Twenty-seven (73%) patients were treated within 3 days from symptom onset. At the last available clinical follow-up, ONP resolution was complete in 14 (37.8%) patients and partial in 19 (51.4%). Only 4 (10.8%) patients showed no signs of nerve recovery. In multivariate analysis, partial ONP and longer follow-up durations were predictors of complete nerve recovery. Treatment timing, type of endovascular embolization, subarachnoid hemorrhage, and initial degree of aneurysm occlusion were not predictors of nerve recovery. Of 169 patients reported in the literature (including ours), ONP resolved completely in 73 (43.2%) patients and partially in 73 (43.2%).
  
  
  CONCLUSIONS
  Endovascular therapy is a safe and highly efficient alternative to surgical clipping for PcomA aneurysms with ONP.
authors.affiliation: Department of Neurosurgery, Thomas Jefferson University and Jefferson Hospital for Neuroscience, Philadelphia, Pennsylvania 19107, USA.
authors.forename: N
authors.initials: N
authors.lastname: Chalouhi
authors.forename: T
authors.initials: T
authors.lastname: Theofanis
authors.forename: P
authors.initials: P
authors.lastname: Jabbour
authors.forename: A S
authors.initials: AS
authors.lastname: Dumont
authors.forename: L F
authors.initials: LF
authors.lastname: Gonzalez
authors.forename: R M
authors.initials: RM
authors.lastname: Starke
authors.forename: D
authors.initials: D
authors.lastname: Gordon
authors.forename: R
authors.initials: R
authors.lastname: Rosenwasser
authors.forename: S
authors.initials: S
authors.lastname: Tjoumakaris
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D057510:Endovascular Procedures / Q000379:methods*; D005260:Female; D006801:Humans; D002532:Intracranial Aneurysm / Q000150:complications* / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D015840:Oculomotor Nerve Diseases / Q000150:complications*; D011237:Predictive Value of Tests; D020127:Recovery of Function; D012189:Retrospective Studies; D016896:Treatment Outcome