title: The total synthesis of corallopyronin A and myxopyronin B.
abstract: Leading the way: the synthesis of natural products with new biological targets is one of the driving forces for the development of new antibiotics. The synthesis of the two secondary metabolites corallopyronin and myxopyronin have been achieved, which are prominent leads for the inhibition of bacterial RNA polymerase.
authors.affiliation: Institut für Organische Chemie, Centre of Biomolecular Drug Research, Leibniz University Hannover, Germany.
authors.forename: Andreas
authors.initials: A
authors.lastname: Rentsch
authors.forename: Markus
authors.initials: M
authors.lastname: Kalesse
mesh_terms: D012321:DNA-Directed RNA Polymerases / Q000378:metabolism; D007783:Lactones / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D007783:Lactones; C532894:corallopyronin A; C040323:myxopyronin B; D012321:DNA-Directed RNA Polymerases