title: Role of genomics on the path to personalized medicine.
abstract: Technology continues to lead the field of personalized medicine as the interpretation of the human genome is progressing. The cost and duration of genomic sequencing continue to decrease sharply and there is intensive research aimed at understanding how the changes that occur within the genome can alter its function and the genomic variations that constitute individual susceptibility to diseases and responses to therapy. The overlay of a personal genome with the personal medical record of patients has a potential to improve prediction and prevention and to allow a more pro-active therapeutic strategy. It is evident that pharmacogenomics and individualized drug therapy are the building blocks of personalized medicine. A growing number of drugs are now used for the treatment of cancer in subjects selected by a companion genetic test. Personalized medicine while based upon genomic knowledge of the individual requires equally essential personalised environmental information as well as the understanding of every subject's capacity for health-promoting behaviour.
authors.affiliation: Research Centre, Centre hospitalier de l'Université de Montréal-Technopôle Angus, 2901 Rachel Street East, Room 314, H1W 4A4, Montreal, Quebec, Canada.
authors.forename: Johanne
authors.initials: J
authors.lastname: Tremblay
authors.forename: Pavel
authors.initials: P
authors.lastname: Hamet
mesh_terms: D003695:Delivery of Health Care / Q000379:methods / Q000592:standards / Q000639:trends*; D059647:Gene-Environment Interaction; D005819:Genetic Markers; D020022:Genetic Predisposition to Disease; D005820:Genetic Testing; D014644:Genetic Variation; D015894:Genome, Human; D023281:Genomics; D015438:Health Behavior; D006801:Humans; D010597:Pharmacogenetics; D057285:Precision Medicine / Q000379:methods / Q000639:trends*; D011639:Public Opinion; D016896:Treatment Outcome
chemical_list: D005819:Genetic Markers