title: New insights into anticarcinogenic properties of adiponectin: a potential therapeutic approach in breast cancer?
abstract: Obesity is a recognized breast cancer risk factor in postmenopausal women. A recent hypothesis suggests a major role for adipose tissue in carcinogenesis. During many years, the adipose tissue was only considered as a fat storage of energy. This tissue is now described as an endocrine organ secreting a large range of molecules called adipokines. Among these adipokines, adiponectin may play a major role in breast cancer. Plasma adiponectin levels were found to be decreased in cases of breast cancer and in obese patients. Adiponectin may act directly on breast cancer cells by inhibiting proliferation and angiogenesis or by stimulating apoptosis. Increasing adiponectin levels may be of major importance in the prevention and/or the treatment of breast cancer. This therapeutic approach may be of particular significance for obese patients. The beneficial effects of adiponectin and its possible therapeutic applications will be discussed in this review.
authors.affiliation: Clermont Université, Université d'Auvergne, UFR Pharmacie, Laboratoire SVFp, 28 Place Henri Dunant, F-63000 Clermont-Ferrand, France. laetitia.delort@udamail.fr
authors.forename: Laetitia
authors.initials: L
authors.lastname: Delort
authors.forename: Thierry
authors.initials: T
authors.lastname: Jardé
authors.forename: Virginie
authors.initials: V
authors.lastname: Dubois
authors.forename: Marie-Paule
authors.initials: MP
authors.lastname: Vasson
authors.forename: Florence
authors.initials: F
authors.lastname: Caldefie-Chézet
mesh_terms: D052242:Adiponectin / Q000097:blood / Q000235:genetics / Q000494:pharmacology; D000273:Adipose Tissue / Q000378:metabolism; D016588:Anticarcinogenic Agents; D001943:Breast Neoplasms / Q000235:genetics / Q000378:metabolism / Q000628:therapy*; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D004032:Diet; D005260:Female; D015870:Gene Expression; D020022:Genetic Predisposition to Disease; D006801:Humans; D008297:Male; D009765:Obesity / Q000097:blood / Q000150:complications; D012333:RNA, Messenger / Q000032:analysis; D054419:Receptors, Adiponectin; D012307:Risk Factors
chemical_list: D052242:Adiponectin; D016588:Anticarcinogenic Agents; D012333:RNA, Messenger; D054419:Receptors, Adiponectin