title: Impact of acute exercise on brachial artery flow-mediated dilatation in young healthy people.
abstract: BACKGROUND
  Although chronic effects of exercise on endothelial function are established, the impact of acute exercise on flow-mediated dilatation (FMD) of brachial artery has not been elucidated yet.
  
  
  METHODS
  Eighty-six young healthy volunteers were prospectively enrolled from January 2011 to December 2011. The subjects completed FMD tests at rest and immediately after treadmill exercise test. Primary outcome was the impact of acute exercise on FMD, measured by the difference of FMD before and after exercise. Secondary outcomes were the relationship of gender and exercise habit with FMD.
  
  
  RESULTS
  Seventy-four subjects who met the eligibility criteria were included for analysis. Thirty-five (47.3%) were male, and the mean age was 22.7±2.7 years. FMD was reduced after exercise (8.98±4.69 to 7.51±4.03%; P=0.017) and the reduction was found in female group (10.36±5.26 to 7.62±3.71%; P=0.002) but not in male group. Post-exercise FMD was significantly impaired in subjects who did not exercise regularly (6.92±3.13% versus 8.95±5.33%; P=0.003). The decrease of FMD after exercise was greater in female group (-2.75±5.28% versus 0.27±3.24%; P=0.003) and was associated with exercise habit (β=2.532; P=0.027).
  
  
  CONCLUSIONS
  In healthy young subjects, FMD was reduced after a bout of acute exercise. The impact of acute exercise showed significant differences according to gender and exercise habit. FMD impairment after acute exercise was observed in females and subjects without regular exercise.
authors.affiliation: Division of Cardiology, Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea.
authors.forename: In-Chang
authors.initials: IC
authors.lastname: Hwang
authors.forename: Kyung-Hee
authors.initials: KH
authors.lastname: Kim
authors.forename: Won-Suk
authors.initials: WS
authors.lastname: Choi
authors.forename: Hyun-Jin
authors.initials: HJ
authors.lastname: Kim
authors.forename: Moon-Sun
authors.initials: MS
authors.lastname: Im
authors.forename: Yong-Jin
authors.initials: YJ
authors.lastname: Kim
authors.forename: Sang-Hyun
authors.initials: SH
authors.lastname: Kim
authors.forename: Myung-A
authors.initials: MA
authors.lastname: Kim
authors.forename: Dae-Won
authors.initials: DW
authors.lastname: Sohn
authors.forename: Joo-Hee
authors.initials: JH
authors.lastname: Zo
mesh_terms: D000328:Adult; D000367:Age Factors; D001916:Brachial Artery / Q000502:physiology*; D015331:Cohort Studies; D004730:Endothelium, Vascular / Q000502:physiology; D015444:Exercise / Q000502:physiology*; D005260:Female; D015438:Health Behavior; D006801:Humans; D008297:Male; D012039:Regional Blood Flow / Q000502:physiology; D012737:Sex Factors; D014664:Vasodilation / Q000502:physiology*; D055815:Young Adult