title: Inverse correlation of intracellular calcium and cyclic AMP levels in renal cell carcinoma.
abstract: Renal cell carcinoma (RCC) is the most common renal tumour in adults. Altered levels of secondary messengers, that is, intracellular calcium and cyclic AMP (cAMP), have been implicated in the pathogenesis of various malignancies. In the present study, we measured levels of intracellular calcium and cAMP in RCC. The intracellular calcium level was significantly reduced, whereas the cAMP level was significantly augmented in RCC as compared with adjacent grossly normal renal parenchyma.
authors.affiliation: Department of Biochemistry, PGIMER, Chandigarh, India.
authors.forename: Ujjawal
authors.initials: U
authors.lastname: Sharma
authors.forename: Shrawan Kumar
authors.initials: SK
authors.lastname: Singh
authors.forename: Prasad
authors.initials: P
authors.lastname: Rajendra
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002118:Calcium / Q000378:metabolism*; D002292:Carcinoma, Renal Cell / Q000378:metabolism*; D002851:Chromatography, High Pressure Liquid; D000242:Cyclic AMP / Q000378:metabolism*; D005260:Female; D006801:Humans; D007668:Kidney / Q000378:metabolism; D007680:Kidney Neoplasms / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D055815:Young Adult
chemical_list: D000242:Cyclic AMP; D002118:Calcium