title: Molecular adaptations to concurrent training.
abstract: This study investigated the chronic effects of concurrent training (CT) on morphological and molecular adaptations. 37 men (age=23.7±5.5 year) were divided into 4 groups: interval (IT), strength (ST) and concurrent (CT) training and a control group (C) and underwent 8 weeks of training. Maximum strength (1RM) and muscle cross-sectional area (CSA) were evaluated before and after training. Muscle samples were obtained before the training program and 48 h after the last training session. VO2max improved in 5±0.95% and 15±1.3% (pre- to post-test) in groups CT and IT, respectively, when compared to C. Time to exhaustion (TE) improved from pre- to post-test when compared to C (CT=6.1±0.58%; IT=8.3±0.88%; ST=3.2±0.66%). 1RM increased from pre-to post-test only in ST and CT groups (ST=18.5±3.16%; CT=17.6±3.01%). Similarly, ST and CT groups increased quadriceps CSA from pre-to post-test (6.2±1.4%; 7.8±1.66%). The p70S6K1 total protein content increased after CT. The ST group showed increased Akt phosphorylation at Ser473 (45.0±3.3%) whereas AMPK phosphorylation at Thr172 increased only in IT group, (100±17.6%). In summary, our data suggest that despite the differences in molecular adaptations between training regimens, CT did not blunt muscle strength and hypertrophy increments when compared with ST.
authors.affiliation: Department of Sport, School of Physical Education and Sport, University of São Paulo, SP, Brazil. desouza.eo@gmail.com
authors.forename: E O
authors.initials: EO
authors.lastname: de Souza
authors.forename: V
authors.initials: V
authors.lastname: Tricoli
authors.forename: H
authors.initials: H
authors.lastname: Roschel
authors.forename: P C
authors.initials: PC
authors.lastname: Brum
authors.forename: A V N
authors.initials: AV
authors.lastname: Bacurau
authors.forename: J C B
authors.initials: JC
authors.lastname: Ferreira
authors.forename: M S
authors.initials: MS
authors.lastname: Aoki
authors.forename: M
authors.initials: M
authors.lastname: Neves
authors.forename: A Y
authors.initials: AY
authors.lastname: Aihara
authors.forename: A
authors.initials: A
authors.lastname: da Rocha Correa Fernandes
authors.forename: C
authors.initials: C
authors.lastname: Ugrinowitsch
mesh_terms: D055372:AMP-Activated Protein Kinases / Q000378:metabolism*; D000328:Adult; D015415:Biomarkers / Q000378:metabolism; D001823:Body Composition; D004591:Electrophoresis, Polyacrylamide Gel; D015444:Exercise / Q000502:physiology*; D005080:Exercise Test; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D053580:Muscle Strength / Q000502:physiology*; D010101:Oxygen Consumption; D010766:Phosphorylation; D010807:Physical Endurance / Q000502:physiology; D051057:Proto-Oncogene Proteins c-akt / Q000378:metabolism*; D052097:Quadriceps Muscle / Q000201:enzymology* / Q000254:growth & development; D055070:Resistance Training / Q000379:methods; D038762:Ribosomal Protein S6 Kinases, 70-kDa / Q000378:metabolism*
chemical_list: D015415:Biomarkers; D051057:Proto-Oncogene Proteins c-akt; D038762:Ribosomal Protein S6 Kinases, 70-kDa; C448901:ribosomal protein S6 kinase, 70kD, polypeptide 1; D055372:AMP-Activated Protein Kinases