title: 2-(N-Benzyl-N-phenylsulfonamido)alkyl amide derivatives as γ-secretase inhibitors.
abstract: A series of (N-benzyl-N-phenylsulfonamido)alkyl amides were developed from classic and parallel synthesis strategies. Compounds with good in vitro and in vivo γ-secretase activity were identified and described.
authors.affiliation: Molecular Sciences and Candidate Optimization and Neuroscience Discovery Biology, Bristol-Myers Squibb R&D, 5 Research Parkway, Wallingford, CT 06492, United States. parkerm@bms.com
authors.forename: Michael F
authors.initials: MF
authors.lastname: Parker
authors.forename: Donna M
authors.initials: DM
authors.lastname: Barten
authors.forename: Carl P
authors.initials: CP
authors.lastname: Bergstrom
authors.forename: Joanne J
authors.initials: JJ
authors.lastname: Bronson
authors.forename: Jason A
authors.initials: JA
authors.lastname: Corsa
authors.forename: Michael F
authors.initials: MF
authors.lastname: Dee
authors.forename: Yonghua
authors.initials: Y
authors.lastname: Gai
authors.forename: Valerie L
authors.initials: VL
authors.lastname: Guss
authors.forename: Mendi A
authors.initials: MA
authors.lastname: Higgins
authors.forename: Daniel J
authors.initials: DJ
authors.lastname: Keavy
authors.forename: Alice
authors.initials: A
authors.lastname: Loo
authors.forename: Robert A
authors.initials: RA
authors.lastname: Mate
authors.forename: Larry R
authors.initials: LR
authors.lastname: Marcin
authors.forename: Katharine E
authors.initials: KE
authors.lastname: McElhone
authors.forename: Craig T
authors.initials: CT
authors.lastname: Polson
authors.forename: Susan B
authors.initials: SB
authors.lastname: Roberts
authors.forename: John E
authors.initials: JE
authors.lastname: Macor
mesh_terms: D000577:Amides / Q000138:chemical synthesis / Q000737:chemistry* / Q000378:metabolism; D053829:Amyloid Precursor Protein Secretases / Q000037:antagonists & inhibitors* / Q000378:metabolism; D016229:Amyloid beta-Peptides / Q000378:metabolism; D010446:Peptide Fragments / Q000378:metabolism; D011480:Protease Inhibitors / Q000138:chemical synthesis / Q000737:chemistry* / Q000378:metabolism; D011485:Protein Binding; D013329:Structure-Activity Relationship; D013449:Sulfonamides / Q000737:chemistry*
chemical_list: D000577:Amides; D016229:Amyloid beta-Peptides; D010446:Peptide Fragments; D011480:Protease Inhibitors; D013449:Sulfonamides; C075222:amyloid beta-protein (1-42); D053829:Amyloid Precursor Protein Secretases