title: [Spermatogenic function under the influence of heavy metal salts and its correction by preparation Tivortin].
abstract: Entrance of threshold concentrations of copper, zinc, iron, manganese, lead, chromium into the body of sexually mature male rats leads to secretory malfunction of the testicles, which manifests by a decrease of sperm concentration in the ejaculate, a decrease of percentage of motile gametes, an increase in the proportion of morphologically abnormal sperm forms. The evidence of disorders in spermatogram's parameters is directly depends on the duration of the influence of combination of heavy metal salts. The application of the drug Tivortin against intoxication of heavy metal salts decrease the adverse movement of quantitative and qualitative parameters of rat's spermatogramms, so far as Tivortin improves blood circulation, stimulates cell proliferation and cell differentiation, inhibits oxidative apoptosis. These explain beneficial effects of the drug on the growth and maturation of germ cells in case of the influence heavy metal salts combination on organ and the whole body.
authors.forename: A M
authors.initials: AM
authors.lastname: Romaniuk
authors.forename: S V
authors.initials: SV
authors.lastname: Sauliak
authors.forename: R A
authors.initials: RA
authors.lastname: Moskalenko
authors.forename: Iu V
authors.initials: IuV
authors.lastname: Moskalenko
mesh_terms: D000818:Animals; D017209:Apoptosis / Q000187:drug effects; D001120:Arginine / Q000008:administration & dosage*; D001224:Aspartic Acid / Q000008:administration & dosage*; D002454:Cell Differentiation / Q000187:drug effects; D049109:Cell Proliferation / Q000187:drug effects; D048430:Cell Shape / Q000187:drug effects; D006801:Humans; D007274:Injections, Intraperitoneal; D008297:Male; D019216:Metals, Heavy / Q000633:toxicity*; D020030:Nitric Oxide Donors / Q000008:administration & dosage*; D051381:Rats; D012492:Salts; D013076:Sperm Count; D013081:Sperm Motility / Q000187:drug effects; D013091:Spermatogenesis / Q000187:drug effects*; D013094:Spermatozoa / Q000187:drug effects* / Q000473:pathology; D013737:Testis / Q000098:blood supply / Q000187:drug effects*
chemical_list: D019216:Metals, Heavy; D020030:Nitric Oxide Donors; D012492:Salts; D001224:Aspartic Acid; D001120:Arginine; C024891:arginine aspartate