title: Monostotic Langerhans' cell histiocytosis in a child with central diabetes insipidus.
abstract: Langerhans'cell histiocytosis (LCH) comprises a rare group of reticuloendothelial system disorders that can produce focal or systemic manifestations. Diabetes insipidus is considered to be an important indicator of serious underlying diseases in children, including LCH. We report the case of a young patient with monostotic LCH confined to the mandibular ramus, who was diagnosed with the disease after presenting symptoms of central diabetes insipidus and was satisfactorily treated with multi-agent chemotherapy. Additionally, we discuss the clinical, radiographic, histological and immunohistochemical findings, as well as the multidisciplinary approach of this important disease, which should receive attention by dental practitioners, especially when it occurs in children.
authors.affiliation: Division of Oral Surgery, Department of Clinical Dentistry, Federal University of Ceará, Brazil.
authors.forename: Eduardo Costa Studart
authors.initials: EC
authors.lastname: Soares
authors.forename: Ana Rosa Pinto
authors.initials: AR
authors.lastname: Quidute
authors.forename: Fábio Wildson Gurgel
authors.initials: FW
authors.lastname: Costa
authors.forename: Maria Helane Costa
authors.initials: MH
authors.lastname: Gurgel
authors.forename: Ana Paula Negreiros Nunes
authors.initials: AP
authors.lastname: Alves
authors.forename: Cristiane Sá Roriz
authors.initials: CS
authors.lastname: Fonteles
mesh_terms: D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D050034:Antidiuretic Agents / Q000627:therapeutic use; D002675:Child, Preschool; D054697:Cytostatic Agents / Q000627:therapeutic use; D003894:Deamino Arginine Vasopressin / Q000627:therapeutic use; D003919:Diabetes Insipidus / Q000175:diagnosis*; D003937:Diagnosis, Differential; D005938:Glucocorticoids / Q000627:therapeutic use; D006646:Histiocytosis, Langerhans-Cell / Q000175:diagnosis*; D006801:Humans; D008297:Male; D008336:Mandibular Diseases / Q000175:diagnosis*; D011241:Prednisone / Q000627:therapeutic use; D014747:Vinblastine / Q000627:therapeutic use
chemical_list: D000893:Anti-Inflammatory Agents; D050034:Antidiuretic Agents; D054697:Cytostatic Agents; D005938:Glucocorticoids; D014747:Vinblastine; D003894:Deamino Arginine Vasopressin; D011241:Prednisone