title: 5-fluorouracil induced cardiotoxicity: review of the literature.
abstract: 5-fluorouracil (5-FU) is a key chemotherapeutic agent in the treatment of many gastrointestinal tract adenocarcinomas. Despite its proven therapeutic efficacy, 5-FU also possesses several undesired cardiac toxicities, including coronary vasospasm, coronary thrombosis, cardiomyopathy, and sudden cardiac death. This review addresses the incidence, mechanisms of action, clinical presentation, risk stratification, and management of 5-FU associated cardiotoxicity; it also highlights the importance of careful pre-administration cardiac risk stratification and close monitoring during and after drug administration.
authors.affiliation: Department of Medicine, Warren Alpert Medical School of Brown University, Providence, Rhode Island 02903, USA. msorrentino@lifespan.org
authors.forename: Michael F
authors.initials: MF
authors.lastname: Sorrentino
authors.forename: Jiwon
authors.initials: J
authors.lastname: Kim
authors.forename: Andrew E
authors.initials: AE
authors.lastname: Foderaro
authors.forename: Alexander G
authors.initials: AG
authors.lastname: Truesdell
mesh_terms: D000818:Animals; D000964:Antimetabolites, Antineoplastic / Q000009:adverse effects*; D003331:Coronary Vessels / Q000187:drug effects / Q000473:pathology; D016903:Drug Monitoring; D005472:Fluorouracil / Q000009:adverse effects*; D006331:Heart Diseases / Q000139:chemically induced* / Q000175:diagnosis / Q000401:mortality / Q000628:therapy; D006801:Humans; D015994:Incidence; D009206:Myocardium / Q000473:pathology; D018570:Risk Assessment; D012307:Risk Factors
chemical_list: D000964:Antimetabolites, Antineoplastic; D005472:Fluorouracil