title: Dysregulation of miRNA146a versus IRAK1 induces IL-17 persistence in the psoriatic skin lesions.
abstract: Psoriasis is a common chronic inflammatory skin disorder with dysregulation of miRNAs. The expression pattern of miR-146a and target gene IRAK1 in lesions and PBMCs of plaque psoriasis remains unclear. In our study, we found the expression of miR-146a was up-regulated both in lesions and PBMCs of psoriatic patients, and positively correlated with IL-17 expression, whereas the target gene IRAK1 expression was expressed differentially in lesions and peripheral blood. Inability of miR-146a inhibiting target gene IRAK1 may contribute to the persistent inflammation in lesions of psoriasis.
authors.affiliation: Department of Dermatology, Huashan Hospital, Fudan University, 12 Wulumuqi Road-Middle, Shanghai 200040, China.
authors.forename: Ping
authors.initials: P
authors.lastname: Xia
authors.forename: Xu
authors.initials: X
authors.lastname: Fang
authors.forename: Zheng-hua
authors.initials: ZH
authors.lastname: Zhang
authors.forename: Qiong
authors.initials: Q
authors.lastname: Huang
authors.forename: Ke-xiang
authors.initials: KX
authors.lastname: Yan
authors.forename: Ke-fei
authors.initials: KF
authors.lastname: Kang
authors.forename: Ling
authors.initials: L
authors.lastname: Han
authors.forename: Zhi-zhong
authors.initials: ZZ
authors.lastname: Zheng
mesh_terms: D000328:Adult; D005260:Female; D005786:Gene Expression Regulation; D006801:Humans; D007371:Interferon-gamma / Q000097:blood; D053592:Interleukin-1 Receptor-Associated Kinases / Q000235:genetics / Q000378:metabolism*; D020381:Interleukin-17 / Q000097:blood / Q000378:metabolism*; D008297:Male; D035683:MicroRNAs / Q000235:genetics* / Q000378:metabolism*; D011565:Psoriasis / Q000276:immunology / Q000378:metabolism*; D012867:Skin / Q000378:metabolism; D014409:Tumor Necrosis Factor-alpha / Q000097:blood
chemical_list: D020381:Interleukin-17; C542542:MIRN146 microRNA, human; D035683:MicroRNAs; D014409:Tumor Necrosis Factor-alpha; D007371:Interferon-gamma; C507768:IRAK1 protein, human; D053592:Interleukin-1 Receptor-Associated Kinases