title: Soluble MICA and a MICA variation as possible prognostic biomarkers for HBV-induced hepatocellular carcinoma.
abstract: MHC class I polypeptide-related chain A (MICA) molecule is induced in response to viral infection and various types of stress. We recently reported that a single nucleotide polymorphism (SNP) rs2596542 located in the MICA promoter region was significantly associated with the risk for hepatitis C virus (HCV)-induced hepatocellular carcinoma (HCC) and also with serum levels of soluble MICA (sMICA). In this study, we focused on the possible involvement of MICA in liver carcinogenesis related to hepatitis B virus (HBV) infection and examined correlation between the MICA polymorphism and the serum sMICA levels in HBV-induced HCC patients. The genetic association analysis revealed a nominal association with an SNP rs2596542; a G allele was considered to increase the risk of HBV-induced HCC (P = 0.029 with odds ratio of 1.19). We also found a significant elevation of sMICA in HBV-induced HCC cases. Moreover, a G allele of SNP rs2596542 was significantly associated with increased sMICA levels (P = 0.009). Interestingly, HCC patients with the high serum level of sMICA (>5 pg/ml) exhibited poorer prognosis than those with the low serum level of sMICA (≤5 pg/ml) (P = 0.008). Thus, our results highlight the importance of MICA genetic variations and the significance of sMICA as a predictive biomarker for HBV-induced HCC.
authors.affiliation: Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, The University of Tokyo, Tokyo, Japan. koichima@ims.u-tokyo.ac.jp
authors.forename: Vinod
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authors.lastname: Kumar
authors.forename: Paulisally Hau
authors.initials: PH
authors.lastname: Yi Lo
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authors.lastname: Sawai
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authors.lastname: Kato
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authors.lastname: Takahashi
authors.forename: Zhenzhong
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authors.lastname: Deng
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authors.lastname: Koike
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authors.lastname: Tanikawa
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authors.lastname: Kamatani
authors.forename: Michiaki
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mesh_terms: D000328:Adult; D000368:Aged; D014408:Biomarkers, Tumor / Q000097:blood / Q000235:genetics; D006528:Carcinoma, Hepatocellular / Q000097:blood* / Q000235:genetics* / Q000401:mortality / Q000821:virology; D005260:Female; D006515:Hepatitis B virus; D015395:Histocompatibility Antigens Class I / Q000097:blood* / Q000235:genetics*; D006801:Humans; D008113:Liver Neoplasms / Q000097:blood* / Q000235:genetics* / Q000401:mortality / Q000821:virology; D008297:Male; D008875:Middle Aged; D018598:Minisatellite Repeats; D009389:Neovascularization, Pathologic / Q000097:blood / Q000235:genetics; D020641:Polymorphism, Single Nucleotide; D011379:Prognosis
chemical_list: D014408:Biomarkers, Tumor; D015395:Histocompatibility Antigens Class I; C099187:MHC class I-related chain A