title: Encapsulation of biomacromolecules within polymersomes by electroporation.
abstract: Biological macromolecules can be encapsulated into preformed polymersomes by controlled temporary destabilization of the vesicle membrane. The morphology and the size of the polymersome are unchanged after electroporation, suggesting that the polymersome membrane is reformed. The surface charge of the biomacromolecules plays a key role for the electroporation process.
authors.affiliation: The Krebs Institute, UK.
authors.forename: Linge
authors.initials: L
authors.lastname: Wang
authors.forename: Luca
authors.initials: L
authors.lastname: Chierico
authors.forename: Daniel
authors.initials: D
authors.lastname: Little
authors.forename: Nisa
authors.initials: N
authors.lastname: Patikarnmonthon
authors.forename: Zhou
authors.initials: Z
authors.lastname: Yang
authors.forename: Mimoun
authors.initials: M
authors.lastname: Azzouz
authors.forename: Jeppe
authors.initials: J
authors.lastname: Madsen
authors.forename: Steven P
authors.initials: SP
authors.lastname: Armes
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Battaglia
mesh_terms: D000818:Animals; D002417:Cattle; D004247:DNA / Q000737:chemistry; D018274:Electroporation; D057809:HEK293 Cells; D006801:Humans; D007074:Immunoglobulin G / Q000737:chemistry; D046911:Macromolecular Substances / Q000737:chemistry; D008689:Methacrylates / Q000737:chemistry*; D009113:Muramidase / Q000737:chemistry / Q000378:metabolism; D009211:Myoglobin / Q000737:chemistry; D010767:Phosphorylcholine / Q000031:analogs & derivatives* / Q000737:chemistry; D011109:Polymethacrylic Acids / Q000737:chemistry*; D034741:RNA, Small Interfering / Q000737:chemistry; D012710:Serum Albumin, Bovine / Q000737:chemistry
chemical_list: D007074:Immunoglobulin G; D046911:Macromolecular Substances; D008689:Methacrylates; D009211:Myoglobin; D011109:Polymethacrylic Acids; D034741:RNA, Small Interfering; C511861:poly(2-(diisopropylamino)ethyl methacrylate); C115766:poly(2-methacryloyloxyethyl-phosphorylcholine); D010767:Phosphorylcholine; D012710:Serum Albumin, Bovine; D004247:DNA; D009113:Muramidase