title: Crosstalk of the plasma contact system with bacteria.
abstract: Activation of the plasma contact system triggers several cascade systems such as the kallikrein-kinin system, the intrinsic pathway of coagulation, the classical complement cascade and the fibrinolytic system. Recent studies have shown a critical role of the contact system for arterial and venous thrombus formation and thromboembolic disease. In contrast, the function of the contact system for host-defense reactions and its physiological functions have remained enigmatic. Experimental animal studies and clinical data have linked the contact system to bacterial infections with implications for sepsis disease. The present review summarizes the role of the contact system and its activation for bacterial infections.
authors.affiliation: Department of Molecular Medicine and Surgery, Karolinska Institutet and University Hospital, Stockholm, Sweden.
authors.forename: Katrin Faye
authors.initials: KF
authors.lastname: Nickel
authors.forename: Thomas
authors.initials: T
authors.lastname: Renné
mesh_terms: D000818:Animals; D001419:Bacteria / Q000276:immunology / Q000378:metabolism*; D001424:Bacterial Infections / Q000097:blood* / Q000150:complications / Q000276:immunology / Q000382:microbiology; D001777:Blood Coagulation; D002199:Capillary Permeability; D003171:Complement Pathway, Classical; D005337:Fibrin / Q000378:metabolism; D005342:Fibrinolysis; D006801:Humans; D007113:Immunity, Innate; D016234:Kallikrein-Kinin System; D018805:Sepsis / Q000097:blood / Q000276:immunology / Q000382:microbiology; D015398:Signal Transduction
chemical_list: D005337:Fibrin