title: The polyoma virus large T binding protein p150 is a transcriptional repressor of c-MYC.
abstract: p150, product of the SALL2 gene, is a binding partner of the polyoma virus large T antigen and a putative tumor suppressor. p150 binds to the nuclease hypersensitive element of the c-MYC promoter and represses c-MYC transcription. Overexpression of p150 in human ovarian surface epithelial cells leads to decreased expression, and downregulation to increased expression, of c-MYC. c-MYC is repressed upon restoration of p150 to ovarian carcinoma cells. Induction of apoptosis by etoposide results in recruitment of p150 to the c-MYC promoter and to repression of c-MYC. Analysis of data in The Cancer Genome Atlas shows negative correlations between SALL2 and c-MYC expression in four common solid tumor types.
authors.affiliation: Department of Microbiology and Immunobiology, Harvard Medical School, Boston, Massachusetts, United States of America.
authors.forename: Chang Kyoo
authors.initials: CK
authors.lastname: Sung
authors.forename: Hyungshin
authors.initials: H
authors.lastname: Yim
authors.forename: Hongcang
authors.initials: H
authors.lastname: Gu
authors.forename: Dawei
authors.initials: D
authors.lastname: Li
authors.forename: Erik
authors.initials: E
authors.lastname: Andrews
authors.forename: Sekhar
authors.initials: S
authors.lastname: Duraisamy
authors.forename: Cheng
authors.initials: C
authors.lastname: Li
authors.forename: Ronny
authors.initials: R
authors.lastname: Drapkin
authors.forename: Thomas
authors.initials: T
authors.lastname: Benjamin
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000494:pharmacology; D001483:Base Sequence; D045744:Cell Line, Tumor; D004268:DNA-Binding Proteins; D005047:Etoposide / Q000494:pharmacology; D015972:Gene Expression Regulation, Neoplastic; D016147:Genes, Tumor Suppressor; D006801:Humans; D008969:Molecular Sequence Data; D009369:Neoplasms / Q000235:genetics / Q000378:metabolism; D011401:Promoter Regions, Genetic; D011485:Protein Binding; D016271:Proto-Oncogene Proteins c-myc / Q000235:genetics* / Q000378:metabolism; D014157:Transcription Factors / Q000235:genetics* / Q000378:metabolism; D014158:Transcription, Genetic
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D004268:DNA-Binding Proteins; C489427:MYC protein, human; D016271:Proto-Oncogene Proteins c-myc; C104147:SALL2 protein, human; D014157:Transcription Factors; D005047:Etoposide