title: The concept of RNA-assisted protein folding: representation of amino acid kinetics at the tRNA level.
abstract: Transfer RNA molecules (tRNA) have the thermodynamic potential to interact with each other to form dimers (hybridization energy, dG=-33.2±6.7 kcal/mole, compared to the folding energy of the cloverleaf configuration, dG=-25±4.4 kcal/mole, p<0.0001). The dG values have a strong negative correlation with the frequency of co-locations and substitutions of associated amino acids. We suggest that tRNA interactions participate in determining amino acid interactions (co-locations) and consequently the 3D structures of peptides.
authors.affiliation: Karolinska Institute, Stockholm, Sweden. jan.biro@att.net
authors.forename: Jan C
authors.initials: JC
authors.lastname: Biro
authors.forename: Josephine M K
authors.initials: JM
authors.lastname: Biro
mesh_terms: D019943:Amino Acid Substitution; D000596:Amino Acids / Q000378:metabolism*; D001483:Base Sequence; D007328:Insulin / Q000737:chemistry / Q000378:metabolism; D007700:Kinetics; D008954:Models, Biological; D008969:Molecular Sequence Data; D014176:Protein Biosynthesis; D017510:Protein Folding; D059370:RNA Folding; D012343:RNA, Transfer / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D016415:Sequence Alignment; D013816:Thermodynamics
chemical_list: D000596:Amino Acids; D007328:Insulin; D012343:RNA, Transfer