title: Preserved CD4 T-cell telomere length during long-lasting HIV-2 infection.
abstract: HIV-2 infection features a much slower course than HIV-1 infection, often asymptomatic for over 20 years, without antiretroviral therapy (ART). Nevertheless, CD4 T cells progressively decline, in direct correlation with immune activation and cell cycling. We report, for the first time, preserved telomere length within naive and memory CD4 subsets in prolonged HIV-2 infection despite the increased CD4 turnover.
authors.affiliation: Unidade de Imunologia Clínica, Instituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa, 1649-028 Lisboa, Portugal.
authors.forename: Rita
authors.initials: R
authors.lastname: Tendeiro
authors.forename: Adriana S
authors.initials: AS
authors.lastname: Albuquerque
authors.forename: Russell B
authors.initials: RB
authors.lastname: Foxall
authors.forename: Rita
authors.initials: R
authors.lastname: Cavaleiro
authors.forename: Rui S
authors.initials: RS
authors.lastname: Soares
authors.forename: António P
authors.initials: AP
authors.lastname: Baptista
authors.forename: Maria V D
authors.initials: MV
authors.lastname: Soares
authors.forename: Perpétua
authors.initials: P
authors.lastname: Gomes
authors.forename: Ana E
authors.initials: AE
authors.lastname: Sousa
mesh_terms: D000328:Adult; D018791:CD4 Lymphocyte Count; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology*; D015331:Cohort Studies; D005260:Female; D015658:HIV Infections / Q000276:immunology*; D015497:HIV-1 / Q000276:immunology*; D015498:HIV-2 / Q000276:immunology*; D006801:Humans; D016014:Linear Models; D008297:Male; D008875:Middle Aged; D016615:Telomere / Q000276:immunology*; D013997:Time Factors