title: Paranasal sinus rhabdomyosarcoma: a rare tumor of poor prognosis.
abstract: BACKGROUND
  Rhabdomyosarcoma (RMS) is a rare sarcoma, in which paranasal sinus locations are exceptional in adults.
  
  
  METHODS
  We report a case of ethmoid metastatic RMS in a 48-year-old patient, discovered in connection with recurrent epistaxis associated with exophthalmia and ophthalmoplegia. The tumor was inoperable and chemotherapy based on adriamycin was initiated. The course was, however, marked by rapid worsening of symptoms and the patient's death.
  
  
  CONCLUSIONS
  Paranasal sinus RMS shows no specific clinical signs, and diagnosis is mainly based on immunohistochemical analysis. The association of surgery and chemo-radiotherapy is the optimal attitude, but surgical resection is often impossible due to local extension. Prognosis in adults is poor.
authors.affiliation: Service d'oto-rhinolaryngologie et chirurgie cervico-faciale, CHU de Limoges, 2, avenue Martin-Luther-King, 87000 Limoges, France.
authors.forename: A
authors.initials: A
authors.lastname: El Sanharawi
authors.forename: B
authors.initials: B
authors.lastname: Coulibaly
authors.forename: J-P
authors.initials: JP
authors.lastname: Bessede
authors.forename: K
authors.initials: K
authors.lastname: Aubry
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols; D059248:Chemoradiotherapy; D018450:Disease Progression; D004317:Doxorubicin / Q000008:administration & dosage; D004844:Epistaxis / Q000209:etiology; D005005:Ethmoid Sinus; D005094:Exophthalmos / Q000209:etiology; D017809:Fatal Outcome; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D009367:Neoplasm Staging; D009886:Ophthalmoplegia / Q000209:etiology; D010255:Paranasal Sinus Neoplasms / Q000175:diagnosis* / Q000473:pathology / Q000628:therapy; D049268:Positron-Emission Tomography; D011379:Prognosis; D012208:Rhabdomyosarcoma / Q000175:diagnosis* / Q000473:pathology / Q000628:therapy; D014057:Tomography, X-Ray Computed; D051598:Whole Body Imaging
chemical_list: D004317:Doxorubicin