title: Cerebral malaria: we have come a long way.
abstract: Despite decades of research, cerebral malaria remains one of the most serious complications of Plasmodium infection and is a significant burden in Sub-Saharan Africa, where, despite effective antiparasitic treatment, survivors develop long-term neurological sequelae. Although much remains to be discovered about the pathogenesis of cerebral malaria, The American Journal of Pathology has been seminal in presenting original research from both human and experimental models. These studies have afforded significant insight into the mechanism of cerebral damage in this devastating disease. The present review highlights information gleaned from these studies, especially in terms of their contributions to the understanding of cerebral malaria.
authors.affiliation: Division of Parasitology and Tropical Medicine, Department of Pathology, Albert Einstein College of Medicine, Bronx, New York, USA.
authors.forename: Henry J
authors.initials: HJ
authors.lastname: Shikani
authors.forename: Brandi D
authors.initials: BD
authors.lastname: Freeman
authors.forename: Michael P
authors.initials: MP
authors.lastname: Lisanti
authors.forename: Louis M
authors.initials: LM
authors.lastname: Weiss
authors.forename: Herbert B
authors.initials: HB
authors.lastname: Tanowitz
authors.forename: Mahalia S
authors.initials: MS
authors.lastname: Desruisseaux
mesh_terms: D000818:Animals; D001812:Blood-Brain Barrier / Q000473:pathology; D006801:Humans; D007249:Inflammation / Q000473:pathology; D016779:Malaria, Cerebral / Q000000981:diagnostic imaging / Q000473:pathology* / Q000628:therapy; D059906:Neuroimaging; D011859:Radiography; D011877:Radionuclide Imaging; D015398:Signal Transduction; D014652:Vascular Diseases / Q000150:complications / Q000473:pathology