title: Hemorrhagic shock due to spontaneous rupture of adrenal neuroblastoma in an infant:  a rare case and review of the literature.
abstract: Spontaneous rupture of adrenal neuroblastoma is very rare in infants, in contrast to neonates. This report describes a 9-month-old boy presenting with acute hemorrhagic shock due to spontaneous rupture of adrenal neuroblastoma. MYCN oncogene amplification may be a predisposing factor for spontaneous rupture and bleeding of neuroblastoma. An appropriate surgical treatment for this condition must be discussed according to the patient's general state and the tumor features, such as staging, the origin, and local invasiveness.
authors.affiliation: Department of Pediatric Surgery, Hokkaido University Hospital, Sapporo, Japan. s-honda@med.hokudai.ac.jp
authors.forename: Shohei
authors.initials: S
authors.lastname: Honda
authors.forename: Hisayuki
authors.initials: H
authors.lastname: Miyagi
authors.forename: Masashi
authors.initials: M
authors.lastname: Minato
authors.forename: Kanako C
authors.initials: KC
authors.lastname: Kubota
authors.forename: Tadao
authors.initials: T
authors.lastname: Okada
mesh_terms: D000310:Adrenal Gland Neoplasms / Q000097:blood / Q000150:complications* / Q000188:drug therapy / Q000235:genetics / Q000601:surgery; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D002945:Cisplatin / Q000008:administration & dosage; D000077324:Crystalloid Solutions; D003520:Cyclophosphamide / Q000008:administration & dosage; D004317:Doxorubicin / Q000008:administration & dosage; D017707:Erythrocyte Transfusion; D016259:Genes, myc; D018380:Hematopoietic Stem Cell Transplantation; D006465:Hemoperitoneum / Q000209:etiology; D006801:Humans; D007223:Infant; D007552:Isotonic Solutions / Q000627:therapeutic use; D008297:Male; D008558:Melphalan / Q000008:administration & dosage; D009447:Neuroblastoma / Q000097:blood / Q000150:complications* / Q000188:drug therapy / Q000235:genetics / Q000601:surgery; D012074:Remission Induction; D012307:Risk Factors; D012422:Rupture, Spontaneous; D012771:Shock, Hemorrhagic / Q000209:etiology* / Q000628:therapy; D013852:Thiotepa / Q000008:administration & dosage; D014182:Transplantation, Autologous; D014750:Vincristine / Q000008:administration & dosage
chemical_list: D000077324:Crystalloid Solutions; D007552:Isotonic Solutions; D014750:Vincristine; D004317:Doxorubicin; D003520:Cyclophosphamide; D013852:Thiotepa; D002945:Cisplatin; D008558:Melphalan