title: Pulmonary hypertension in COPD: results from the ASPIRE registry.
abstract: The phenotype and outcome of severe pulmonary hypertension in chronic obstructive pulmonary disease (COPD) is described in small numbers, and predictors of survival are unknown. Data was retrieved for 101 consecutive, treatment-naïve cases of pulmonary hypertension in COPD. Mean ± SD follow-up was 2.3 ± 1.9 years. 59 patients with COPD and severe pulmonary hypertension, defined by catheter mean pulmonary artery pressure ≥40 mmHg, had significantly lower carbon monoxide diffusion, less severe airflow obstruction but not significantly different emphysema scores on computed tomography compared to 42 patients with mild-moderate pulmonary hypertension. 1- and 3-year survival for severe pulmonary hypertension, at 70% and 33%, respectively, was inferior to 83% and 55%, respectively, for mild-moderate pulmonary hypertension. Mixed venous oxygen saturation, carbon monoxide diffusion, World Health Organization functional class and age, but not severity of airflow obstruction, were independent predictors of outcome. Compassionate treatment with targeted therapies in 43 patients with severe pulmonary hypertension was not associated with a survival benefit, although improvement in functional class and/or fall in pulmonary vascular resistance >20% following treatment identified patients with improved survival. Standard prognostic markers in COPD have limited value in patients with pulmonary hypertension. This study identifies variables that predict outcome in this phenotype. Despite poor prognosis, our data suggest that further evaluation of targeted therapies is warranted.
authors.affiliation: Sheffield Pulmonary Vascular Disease Unit, Royal Hallamshire Hospital, Sheffield, UK.
authors.forename: Judith
authors.initials: J
authors.lastname: Hurdman
authors.forename: Robin
authors.initials: R
authors.lastname: Condliffe
authors.forename: Charlie A
authors.initials: CA
authors.lastname: Elliot
authors.forename: Andrew
authors.initials: A
authors.lastname: Swift
authors.forename: Smitha
authors.initials: S
authors.lastname: Rajaram
authors.forename: Christine
authors.initials: C
authors.lastname: Davies
authors.forename: Catherine
authors.initials: C
authors.lastname: Hill
authors.forename: Neil
authors.initials: N
authors.lastname: Hamilton
authors.forename: Iain J
authors.initials: IJ
authors.lastname: Armstrong
authors.forename: Catherine
authors.initials: C
authors.lastname: Billings
authors.forename: Lauren
authors.initials: L
authors.lastname: Pollard
authors.forename: Jim M
authors.initials: JM
authors.lastname: Wild
authors.forename: Allan
authors.initials: A
authors.lastname: Lawrie
authors.forename: Rod
authors.initials: R
authors.lastname: Lawson
authors.forename: Ian
authors.initials: I
authors.lastname: Sabroe
authors.forename: David G
authors.initials: DG
authors.lastname: Kiely
mesh_terms: D000368:Aged; D001794:Blood Pressure; D015331:Cohort Studies; D004646:Emphysema / Q000150:complications / Q000453:epidemiology; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D006976:Hypertension, Pulmonary / Q000150:complications* / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D010641:Phenotype; D011379:Prognosis; D016016:Proportional Hazards Models; D011651:Pulmonary Artery / Q000473:pathology; D029424:Pulmonary Disease, Chronic Obstructive / Q000150:complications* / Q000453:epidemiology*; D012372:ROC Curve; D012042:Registries; D012129:Respiratory Function Tests; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome; D006113:United Kingdom