title: Role of S100B protein in urine and serum as an early predictor of mortality after severe traumatic brain injury in adults.
abstract: S100B is a calcium-binding protein released into the blood from astroglial cells due to brain injury. Some authors have described a correlation between S100B serum concentration and severity of brain damage. There is not much information about the accuracy of urinary S100B for predicting outcome after severe traumatic brain injury (TBI). 55 patients with severe TBI were included in the study. Blood and urine samples were drawn to determine S100B levels on admission and on the subsequent 24, 48, 72 and 96 h. S100B concentrations (serum and urine) were significantly higher in patients who were dead a month after the accident compared to survivors. ROC-analysis showed that S100B at 24h post-severe TBI is a useful tool for predicting mortality (serum: AUC 0.958, urine: AUC 0.778). The best cut-offs for S100B were 0.461 μg/L and 0.025 μg/L (serum and urine respectively), with a sensitivity of 90% for both measurements and a specificity of 88.4% (serum) and 62.8% (urine). We can state that the determination of S100B levels both in urine and serum acts as a sensitive and an effective biomarker for the early prediction of mortality after severe TBI.
authors.affiliation: Department of Clinical Biochemistry, Virgen del Rocio University Hospital, IBIS/CSIC/University of Seville, Spain.
authors.forename: Ana
authors.initials: A
authors.lastname: Rodríguez-Rodríguez
authors.forename: Juan José
authors.initials: JJ
authors.lastname: Egea-Guerrero
authors.forename: Antonio
authors.initials: A
authors.lastname: León-Justel
authors.forename: Elena
authors.initials: E
authors.lastname: Gordillo-Escobar
authors.forename: Jaume
authors.initials: J
authors.lastname: Revuelto-Rey
authors.forename: Angel
authors.initials: A
authors.lastname: Vilches-Arenas
authors.forename: Antonio
authors.initials: A
authors.lastname: Carrillo-Vico
authors.forename: José María
authors.initials: JM
authors.lastname: Domínguez-Roldán
authors.forename: Francisco
authors.initials: F
authors.lastname: Murillo-Cabezas
authors.forename: Juan Miguel
authors.initials: JM
authors.lastname: Guerrero
mesh_terms: D000328:Adult; D001930:Brain Injuries / Q000097:blood* / Q000175:diagnosis / Q000401:mortality / Q000652:urine*; D005260:Female; D015600:Glasgow Coma Scale; D006801:Humans; D007700:Kinetics; D008297:Male; D008875:Middle Aged; D009414:Nerve Growth Factors / Q000097:blood* / Q000378:metabolism / Q000652:urine*; D011237:Predictive Value of Tests; D011379:Prognosis; D064568:S100 Calcium Binding Protein beta Subunit; D009418:S100 Proteins / Q000097:blood* / Q000378:metabolism / Q000652:urine*; D015599:Trauma Severity Indices
chemical_list: D009414:Nerve Growth Factors; D064568:S100 Calcium Binding Protein beta Subunit; D009418:S100 Proteins; C579160:S100B protein, human