title: A subchronic dietary toxicity study of rice hull fiber in rats.
abstract: We conducted a 90-day feeding study to investigate subchronic toxicity of rice hull fiber. Sprague Dawley rats were randomly divided into four groups; each received a diet containing 0%, 2.5%, 3.75% and 5.0% (w/w) rice hull fiber for 90days. Clinical observations were carried out daily, with weekly measurements of body weight and food consumption. We performed ophthalmic and histological examinations at termination. Blood and urine samples were collected to measure hematology and clinical chemistry parameters. No mortality, ophthalmic abnormalities, or adverse treatment-related effects were seen during clinical observations, hematological tests, or analyses of urine. Macroscopic or microscopic examinations of organs revealed no treatment related abnormalities. The only treatment related significant changes were reduced concentrations of fasting blood glucose (up to 17.6%) and cholesterol (up to 22.0%), typical benefits of dietary fiber, in males treated with 3.75 and 5% rice hull fiber. The no-observed-adverse-effect-level (NOAEL) for rice hull fiber was 5.0% for both genders (females, 3.80g/kg body weight/day; males, 4.11g/kg body weight/day).
authors.affiliation: School of Life Science, Yantai University, Yantai 264005, PR China.
authors.forename: Yonglin
authors.initials: Y
authors.lastname: Gao
authors.forename: Jingyu
authors.initials: J
authors.lastname: Shen
authors.forename: Jungang
authors.initials: J
authors.lastname: Yin
authors.forename: Chunmei
authors.initials: C
authors.lastname: Li
authors.forename: Chengyu
authors.initials: C
authors.lastname: Fu
authors.forename: Susan
authors.initials: S
authors.lastname: Cho
mesh_terms: D000284:Administration, Oral; D000821:Animal Feed; D000818:Animals; D001774:Blood Chemical Analysis; D001786:Blood Glucose / Q000032:analysis; D001835:Body Weight / Q000187:drug effects; D002784:Cholesterol / Q000097:blood; D004032:Diet; D004043:Dietary Fiber / Q000009:adverse effects; D005260:Female; D008297:Male; D019055:No-Observed-Adverse-Effect Level; D009929:Organ Size / Q000187:drug effects; D012275:Oryza / Q000009:adverse effects*; D051381:Rats; D017207:Rats, Sprague-Dawley; D059550:Toxicity Tests, Subchronic
chemical_list: D001786:Blood Glucose; D004043:Dietary Fiber; D002784:Cholesterol