title: Cytoreductive surgery plus HIPEC in platinum-sensitive recurrent ovarian cancer patients: a case-control study on survival in patients with two year follow-up.
abstract: OBJECTIVE
  To compare survival data in platinum-sensitive recurrent ovarian cancer patients submitted to secondary cytoreduction (SCR) plus hyperthermic intraperitoneal intraoperative chemotherapy (HIPEC) (Cases) and a similar group of women not experiencing HIPEC (Controls).
  
  
  METHODS
  Case-control study, matching 30 Cases with 37 Controls, with at least 24 months of follow-up.
  
  
  RESULTS
  Groups were comparable for all characteristics, except for a higher proportion of patients with single-nodule relapses is the Controls (19 vs. 6; p=0.011). Median follow-up time was 46 months in the Cases and 36 months in the Controls. Twenty patients (66.6%) experienced secondary recurrence in the Cases and 37 women (100%) in the Controls (p=0.001). Moreover, 7 (23.3%) and 23 (62.2%) patients died of disease in the Cases and Controls respectively (p=0.003). The duration of secondary response was 26 months in the Cases and 15 months in the Controls (p=0.004).
  
  
  CONCLUSIONS
  The combination of SCR and HIPEC seems to improve survival rate in patients suffering from platinum-sensitive EOC recurrence with respect to no-HIPEC treatments. This result further supports the need of a randomized trial.
authors.affiliation: Division of Gynecologic Oncology, Catholic University of the Sacred Heart, Rome, Italy. anna.fagotti@rm.unicatt.it
authors.forename: Anna
authors.initials: A
authors.lastname: Fagotti
authors.forename: Barbara
authors.initials: B
authors.lastname: Costantini
authors.forename: Marco
authors.initials: M
authors.lastname: Petrillo
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Vizzielli
authors.forename: Francesco
authors.initials: F
authors.lastname: Fanfani
authors.forename: Pasquale Alessandro
authors.initials: PA
authors.lastname: Margariti
authors.forename: Luigi Carlo
authors.initials: LC
authors.lastname: Turco
authors.forename: Elisa
authors.initials: E
authors.lastname: Piovano
authors.forename: Giovanni
authors.initials: G
authors.lastname: Scambia
mesh_terms: D000328:Adult; D000368:Aged; D016022:Case-Control Studies; D003131:Combined Modality Therapy; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D006979:Hyperthermia, Induced; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000628:therapy*; D010051:Ovarian Neoplasms / Q000601:surgery / Q000628:therapy*; D010984:Platinum / Q000627:therapeutic use; D016019:Survival Analysis
chemical_list: D010984:Platinum