title: IP-10 can be measured in dried plasma spots in patients with chronic hepatitis C infection.
abstract: The chemokine IP-10 (CXCL10) is a candidate marker for hepatitis C virus (HCV) fibrosis monitoring. The aim of this proof-of-concept study is to assess if IP-10 measurements from dried plasma spots (DPS) are accurate in HCV-infected patients with either minimal or significant fibrosis. We measured IP-10 levels in plasma and DPS of 21 HCV-infected patients with cirrhosis and 19 patients with no/little fibrosis (determined with FibroScan). Cirrhotic patients had significantly higher levels of IP-10 compared to patients with minimal fibrosis. DPS and plasma measurements of IP-10 are comparable and the correlation was excellent (r(2) = 0.97, p<0.0001). The DPS based method for IP-10 detection performs well in HCV-infected patients with either minimal or significant fibrosis.
authors.affiliation: Clinical Research Centre, Copenhagen University Hospital, Hvidovre, Copenhagen, Denmark. mruhwald@gmail.com
authors.forename: Morten
authors.initials: M
authors.lastname: Ruhwald
authors.forename: Ellen Sloth
authors.initials: ES
authors.lastname: Andersen
authors.forename: Peer Brehm
authors.initials: PB
authors.lastname: Christensen
authors.forename: Belinda Klemmensen
authors.initials: BK
authors.lastname: Moessner
authors.forename: Nina
authors.initials: N
authors.lastname: Weis
mesh_terms: D000328:Adult; D000368:Aged; D015415:Biomarkers / Q000097:blood; D054357:Chemokine CXCL10 / Q000097:blood*; D059788:Dried Blood Spot Testing; D005260:Female; D019698:Hepatitis C, Chronic / Q000097:blood / Q000150:complications / Q000175:diagnosis*; D006801:Humans; D008103:Liver Cirrhosis / Q000097:blood / Q000175:diagnosis / Q000209:etiology; D008297:Male; D008875:Middle Aged; D012372:ROC Curve
chemical_list: D015415:Biomarkers; D054357:Chemokine CXCL10