title: Coumarin glycosides and iridoid glucosides with neuroprotective effects from Hydrangea paniculata.
abstract: Five new coumarin glycosides, umbelliferone 7-O-sophoroside (1), umbelliferone 7-O-β-D-glucopyranosyl(1 → 3)-β-D-glucopyranoside (2), umbelliferone 7-O-β-D-glucopyranosyl(1 → 3)-[β-D-apiofuranosyl(1 → 6)]-β-D-glucopyranoside (3), umbelliferone 7-O-β-D-glucopyranosyl(1 → 2)-β-D-apiofuranosyl(1 → 6)-β-D-glucopyranoside (4), and umbelliferone 7-O-β-D-glucopyranosyl(1 → 5)-β-D-apiofuranosyl(1 → 6)-β-D-glucopyranoside (5), and two new iridoid glucosides, 7-O-E-isoferuloyl loganic acid (6) and 7-O-β-D-glucopyranosyl loganin (7), together with eight known compounds (8-15) were isolated from the stems of Hydrangea paniculata. Their structures were established by spectroscopic analysis and chemical methods. At 10 µM, compounds 1, 3, 5, 6, 8, 9, and 13 showed neuroprotective effects against serum deprivation-induced PC12 cell damage.
authors.affiliation: State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, PR China.
authors.forename: Jing
authors.initials: J
authors.lastname: Shi
authors.forename: Chuang-Jun
authors.initials: CJ
authors.lastname: Li
authors.forename: Jing-Zhi
authors.initials: JZ
authors.lastname: Yang
authors.forename: Yu-He
authors.initials: YH
authors.lastname: Yuan
authors.forename: Nai-Hong
authors.initials: NH
authors.lastname: Chen
authors.forename: Dong-Ming
authors.initials: DM
authors.lastname: Zhang
mesh_terms: D000818:Animals; D003374:Coumarins / Q000302:isolation & purification*; D004353:Drug Evaluation, Preclinical; D031966:Hydrangea / Q000737:chemistry*; D057888:Iridoid Glucosides / Q000302:isolation & purification*; D015394:Molecular Structure; D018696:Neuroprotective Agents / Q000302:isolation & purification*; D016716:PC12 Cells / Q000187:drug effects; D018547:Plant Stems / Q000737:chemistry; D051381:Rats
chemical_list: D003374:Coumarins; D057888:Iridoid Glucosides; D018696:Neuroprotective Agents; C030123:coumarin