title: Effects of lifestyle intervention and meal replacement on glycaemic and body-weight control in Chinese subjects with impaired glucose regulation: a 1-year randomised controlled trial.
abstract: The purpose of the present study was to evaluate the impact of a lifestyle intervention programme, combined with a daily low-glycaemic index meal replacement, on body-weight and glycaemic control in subjects with impaired glucose regulation (IGR). Subjects with IGR were randomly assigned to an intervention group (n 46) and a control group (n 42). Both groups received health counselling at baseline. The intervention group also received a daily meal replacement and intensive lifestyle intervention to promote healthy eating habits during the first 3 months of the study, and follow-up visits performed monthly until the end of the 1-year study. Outcome measurements included changes in plasma glucose, glycated Hb (HbA1c), plasma lipids, body weight, blood pressure and body composition (such as body fat mass and visceral fat area). The results showed that body-weight loss after 1 year was significant in the intervention group compared with the control group (-1·8 (SEM 0·35) v. -0·6 (SEM 0·40) 2·5 kg, P<0·05). The 2 h plasma glucose concentration decreased 1·24 mmol/l in the intervention group and increased 0·85 mmol/l in the control group (P<0·05) compared with their baseline, respectively. A 5 kg body-weight loss at 1 year was associated with a decrease of 1·49 mmol/l in 2 h plasma glucose (P<0·01). The incidence of normal glucose regulation (NGR) in the two groups was significantly different (P=0·001). In conclusion, the combination of regular contact, lifestyle advice and meal replacement is beneficial in promoting IGR to NGR.
authors.affiliation: Clinical Nutrition Center, Huadong Hospital, Fudan University, No. 221, Yan'an (West) Road, Shanghai 200040, People's Republic of China.
authors.forename: Dan-Feng
authors.initials: DF
authors.lastname: Xu
authors.affiliation: Clinical Nutrition Center, Huadong Hospital, Fudan University, No. 221, Yan'an (West) Road, Shanghai 200040, People's Republic of China.
authors.forename: Jian-Qin
authors.initials: JQ
authors.lastname: Sun
authors.affiliation: Clinical Nutrition Center, Huadong Hospital, Fudan University, No. 221, Yan'an (West) Road, Shanghai 200040, People's Republic of China.
authors.forename: Min
authors.initials: M
authors.lastname: Chen
authors.affiliation: Clinical Nutrition Center, Huadong Hospital, Fudan University, No. 221, Yan'an (West) Road, Shanghai 200040, People's Republic of China.
authors.forename: Yan-Qiu
authors.initials: YQ
authors.lastname: Chen
authors.affiliation: Clinical Nutrition Center, Huadong Hospital, Fudan University, No. 221, Yan'an (West) Road, Shanghai 200040, People's Republic of China.
authors.forename: Hua
authors.initials: H
authors.lastname: Xie
authors.affiliation: Clinical Nutrition Center, Huadong Hospital, Fudan University, No. 221, Yan'an (West) Road, Shanghai 200040, People's Republic of China.
authors.forename: Wei-Jia
authors.initials: WJ
authors.lastname: Sun
authors.affiliation: Clinical Nutrition Center, Huadong Hospital, Fudan University, No. 221, Yan'an (West) Road, Shanghai 200040, People's Republic of China.
authors.forename: Yi-Fan
authors.initials: YF
authors.lastname: Lin
authors.affiliation: Clinical Nutrition Center, Huadong Hospital, Fudan University, No. 221, Yan'an (West) Road, Shanghai 200040, People's Republic of China.
authors.forename: Jing-Jing
authors.initials: JJ
authors.lastname: Jiang
authors.affiliation: Caojiadu Community Health Center, Jing'an District, Shanghai, People's Republic of China.
authors.forename: Wei
authors.initials: W
authors.lastname: Sun
authors.affiliation: Caojiadu Community Health Center, Jing'an District, Shanghai, People's Republic of China.
authors.forename: Ai-Fang
authors.initials: AF
authors.lastname: Chen
authors.affiliation: Jing'an Temple Community Health Center, Jing'an District, Shanghai, People's Republic of China.
authors.forename: Qian-Ru
authors.initials: QR
authors.lastname: Tang
mesh_terms: D000368:Aged; D001628:Beverages; D015992:Body Mass Index; D062408:Breakfast; D002681:China; D003131:Combined Modality Therapy; D003924:Diabetes Mellitus, Type 2 / Q000209:etiology / Q000517:prevention & control*; D003927:Diet, Diabetic; D004038:Diet, Reducing; D018450:Disease Progression; D005260:Female; D005500:Follow-Up Studies; D044882:Glucose Metabolism Disorders / Q000150:complications / Q000178:diet therapy / Q000503:physiopathology / Q000628:therapy*; D038321:Glycemic Index; D006293:Health Promotion; D006801:Humans; D008019:Life Style; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000150:complications / Q000178:diet therapy / Q000503:physiopathology / Q000628:therapy*; D010353:Patient Education as Topic; D015431:Weight Loss