title: Comparative evaluation of flavone from Mucuna pruriens and coumarin from Ionidium suffruticosum for hypolipidemic activity in rats fed with high fat diet.
abstract: The objective of the study is a comparative evaluation of flavone isolated from Mucuna pruriens and coumarin isolated from Ionidium suffruticosum was assessed for the hypolipidemic activity in rats fed with high fat diet. The acute toxicity study was found that flavone (M.pruriens) and coumarin (I.suffruticosum) are safe up to 100 mg/kg, so one tenth of this dose (10 mg/kg) was consider as a evaluation dose. High fat diet group of rats showed significant (p<0.001) elevation in plasma total and LDL-cholesterol, triglycerides and phospholipids. Administration of flavone (M. pruriens) and coumarin isolated from (I.suffruticosum) at the dose of 10mg/kg b.wt/day along with high fat diet significantly (p<0.001) prevented the rise in the plasma total and LDL-cholesterol, triglycerides and phospholipids than that of other extracts. However, treatment of coumarin isolated from (I.suffruticosum) had showed more cardio protective effect against hyperlipidemia than that of flavone (M.pruriens).
authors.affiliation: Department of Pharmacy, Annamalai University, Annamalai, Nagar 608 002, India.
authors.forename: Satheesh Kumar
authors.initials: SK
authors.lastname: Dharmarajan
authors.forename: Kottai Muthu
authors.initials: KM
authors.lastname: Arumugam
mesh_terms: D000818:Animals; D001011:Aorta / Q000187:drug effects / Q000378:metabolism; D002316:Cardiotonic Agents / Q000302:isolation & purification / Q000494:pharmacology / Q000633:toxicity; D002784:Cholesterol / Q000097:blood / Q000378:metabolism; D003374:Coumarins / Q000302:isolation & purification / Q000494:pharmacology* / Q000633:toxicity; D059305:Diet, High-Fat / Q000009:adverse effects*; D004353:Drug Evaluation, Preclinical; D047309:Flavones / Q000302:isolation & purification / Q000494:pharmacology* / Q000633:toxicity; D006321:Heart / Q000187:drug effects; D000960:Hypolipidemic Agents / Q000302:isolation & purification / Q000494:pharmacology* / Q000633:toxicity; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D008297:Male; D031299:Mucuna / Q000737:chemistry; D009206:Myocardium / Q000378:metabolism; D010743:Phospholipids / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D014280:Triglycerides / Q000378:metabolism; D029649:Violaceae / Q000737:chemistry
chemical_list: D002316:Cardiotonic Agents; D003374:Coumarins; D047309:Flavones; D000960:Hypolipidemic Agents; D010743:Phospholipids; D014280:Triglycerides; D002784:Cholesterol