title: Replication study in Chinese population and meta-analysis supports association of the 11q23 locus with colorectal cancer.
abstract: BACKGROUND
  A common single nucleotide polymorphism (SNP), rs3802842, located at 11q23, was identified by genome-wide association studies (GWAS) to be significantly associated with the risk of colorectal cancer (CRC); however, the results of following replication studies were not always concordant. Thus, a case-control study and a meta-analysis were performed to clearly discern the effect of this variant in CRC.
  
  
  RESULTS
  We determined the genotypes of rs3802842 in 641 unrelated Chinese patients with CRC and 1037 cancer-free controls. Additionally, a meta-analysis comprising current and previously published studies was conducted. In our case-control study, significant associations between the polymorphism and CRC risk were observed in all genetic models, with an additive OR being 1.45 (95% CI = 1.26-1.67). The meta-analysis of 38534 cases and 39446 controls further confirmed the significant associations in all genetic models but with obvious between-study heterogeneity. Nevertheless, ethnicity, study type and whether subjects affected by Lynch syndrome could synthetically accounted for the heterogeneity. Besides, the cumulative and sensitivity analyses indicated the robust stability of the results.
  
  
  CONCLUSIONS
  The results from our case-control study and meta-analysis provided convincing evidence that rs3802842 significantly contributed to CRC risk.
authors.affiliation: Department of Urology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
authors.forename: Li
authors.initials: L
authors.lastname: Zou
authors.forename: Rong
authors.initials: R
authors.lastname: Zhong
authors.forename: Jiao
authors.initials: J
authors.lastname: Lou
authors.forename: Xuzai
authors.initials: X
authors.lastname: Lu
authors.forename: Qi
authors.initials: Q
authors.lastname: Wang
authors.forename: Yang
authors.initials: Y
authors.lastname: Yang
authors.forename: Jiahong
authors.initials: J
authors.lastname: Xia
authors.forename: Juntao
authors.initials: J
authors.lastname: Ke
authors.forename: Ti
authors.initials: T
authors.lastname: Zhang
authors.forename: Yu
authors.initials: Y
authors.lastname: Sun
authors.forename: Li
authors.initials: L
authors.lastname: Liu
authors.forename: Yongping
authors.initials: Y
authors.lastname: Cui
authors.forename: Haibing
authors.initials: H
authors.lastname: Xiao
authors.forename: Lei
authors.initials: L
authors.lastname: Chang
authors.forename: Ding
authors.initials: D
authors.lastname: Xia
authors.forename: Hua
authors.initials: H
authors.lastname: Xu
mesh_terms: D000328:Adult; D000368:Aged; D044466:Asian People / Q000235:genetics*; D016022:Case-Control Studies; D002681:China; D002880:Chromosomes, Human, Pair 11; D015179:Colorectal Neoplasms / Q000235:genetics*; D019295:Computational Biology / Q000379:methods; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D017594:Publication Bias; D040641:Quantitative Trait Loci