title: Gastrointestinal stromal tumour of the duodenum: single institution experience.
abstract: BACKGROUND
  Primary gastrointestinal stromal tumours (GISTs) of the duodenum are rare. The aim of this study was to review the surgical management of GISTs in this anatomically complex region.
  
  
  METHODS
  Retrospective review from January 1999 to August 2011 of patients with primary GISTs of the duodenum.
  
  
  RESULTS
  Forty-one patients underwent resection of duodenal GISTs. All operations were performed with intent to cure with negative margins of resection. The most common location of origin was the second portion of the duodenum. Local excision (n= 19), segmental resection with primary anastomosis (n= 11) and a pancreatoduodenectomy (n= 11) were performed. Two patients underwent an ampullectomy with local excision. Peri-operative mortality and overall morbidity were 0 and 12, respectively. Patients with high-risk GISTs (P= 0.008) and those who underwent a pancreatoduodenectomy (P= 0.021) were at a greater risk for morbidity. The median follow-up was 18 months. Eight patients developed recurrence. High-risk GISTs and neoplasms with ulceration had the greatest risk for recurrence (P= 0.017, P= 0.029 respectively). The actuarial 3- and 5-year survivals were 85% and 74%, respectively.
  
  
  CONCLUSIONS
  The choice and type of resection depends on the proximity to the ampulla of Vater, involvement of adjacent organs and the ability to obtain negative margins. The morbidity depends on the type of procedure for GIST.
authors.affiliation: Division of Gastroenterologic and General Surgery, Mayo Clinic Rochester, MN, USA.
authors.forename: Ashwin S
authors.initials: AS
authors.lastname: Kamath
authors.forename: Michael G
authors.initials: MG
authors.lastname: Sarr
authors.forename: David M
authors.initials: DM
authors.lastname: Nagorney
authors.forename: Florencia G
authors.initials: FG
authors.lastname: Que
authors.forename: Michael B
authors.initials: MB
authors.lastname: Farnell
authors.forename: Michael L
authors.initials: ML
authors.lastname: Kendrick
authors.forename: Kaye M
authors.initials: KM
authors.lastname: Reid Lombardo
authors.forename: John H
authors.initials: JH
authors.lastname: Donohue
mesh_terms: D000328:Adult; D000368:Aged; D014670:Ampulla of Vater / Q000473:pathology / Q000601:surgery; D000714:Anastomosis, Surgical; D013505:Digestive System Surgical Procedures / Q000009:adverse effects / Q000401:mortality; D004379:Duodenal Neoplasms / Q000401:mortality / Q000473:pathology / Q000601:surgery*; D005260:Female; D046152:Gastrointestinal Stromal Tumors / Q000401:mortality / Q000556:secondary / Q000601:surgery*; D006801:Humans; D053208:Kaplan-Meier Estimate; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D008910:Minnesota; D009364:Neoplasm Recurrence, Local; D016017:Odds Ratio; D016577:Pancreaticoduodenectomy; D016016:Proportional Hazards Models; D012189:Retrospective Studies; D018570:Risk Assessment; D012307:Risk Factors; D013105:Sphincterotomy, Transduodenal; D013997:Time Factors; D016896:Treatment Outcome