title: Anaphylaxis and generalized urticaria from eating Chinese bayberry fruit.
abstract: Chinese bayberry Myrica rubra is a very popular fruit in southeastern China. In spite of its wide consumption, no allergies to this fruit have been reported previously. Here we report on a 40-year-old woman suffering from anaphylaxis to Chinese bayberry fruit. Prick-prick skin tests revealed strong reactions to fresh Chinese bayberry fruits as well as to peach, and weaker reactions to some other fruits including apple, melon, and banana. ImmunoCAP analysis revealed identical titers of specific IgE (4.3 kU(A)/L) to peach extract and its lipid transfer protein (LTP, rPru p 3), which was confirmed by detection of a 9 kD band following immunoblotting. Immunoblot analysis with Chinese bayberry extract gave bands of 22, 45, and 90 kD, but no 9 kD band was recognized. There was also no evidence of LTP recognition for loquat (36 kD) or melon (24 kD). This first report of a severe allergic reaction to Chinese bayberry fruit in a patient with LTP-mediated peach allergy indicates that other as yet unidentified non-pollen related fruit allergens are involved in this new severe fruit allergy.
authors.affiliation: Department of Allergy and Clinical Immunology, the Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China.
authors.forename: Hui-ying
authors.initials: HY
authors.lastname: Wang
authors.forename: Zhong-shan
authors.initials: ZS
authors.lastname: Gao
authors.forename: Zhao-wei
authors.initials: ZW
authors.lastname: Yang
authors.forename: Jing-xin
authors.initials: JX
authors.lastname: Shao
authors.forename: Xiu-zhen
authors.initials: XZ
authors.lastname: Zhao
authors.forename: Yu
authors.initials: Y
authors.lastname: Dai
authors.forename: Ronald
authors.initials: R
authors.lastname: Van Ree
mesh_terms: D000328:Adult; D000485:Allergens / Q000009:adverse effects; D000707:Anaphylaxis / Q000175:diagnosis / Q000209:etiology* / Q000276:immunology; D052179:Antigens, Plant / Q000009:adverse effects / Q000276:immunology; D002352:Carrier Proteins / Q000009:adverse effects / Q000276:immunology; D002681:China; D005260:Female; D005512:Food Hypersensitivity / Q000175:diagnosis / Q000209:etiology* / Q000276:immunology; D005638:Fruit / Q000009:adverse effects / Q000276:immunology; D006801:Humans; D007073:Immunoglobulin E / Q000097:blood; D031641:Myrica / Q000009:adverse effects* / Q000276:immunology*; D010940:Plant Proteins / Q000009:adverse effects / Q000276:immunology; D012882:Skin Tests; D014581:Urticaria / Q000175:diagnosis / Q000209:etiology* / Q000276:immunology
chemical_list: D000485:Allergens; D052179:Antigens, Plant; D002352:Carrier Proteins; D010940:Plant Proteins; C511920:lipid transfer proteins, plant; D007073:Immunoglobulin E