title: Analysis of leukocyte populations in Canadian Holsteins classified as high or low immune responders for antibody- or cell-mediated immune response.
abstract: Selection of dairy cattle for increased milk production with little or no emphasis on health traits leads to an increased prevalence of disease. A possible genetic solution to this problem is to combine production and immune response traits in a weighted selection index. In the current study, leukocyte populations in heifers identified as having a high antibody-mediated immune response (HiAMIR) or high cell-mediated immune response (HiCMIR) phenotype were compared before and after immunization in order to identify leukocyte population profiles associated with these phenotypes. The results demonstrated that the HiCMIR-phenotype animals had a higher baseline proportion of gamma-delta T-cells in peripheral blood. Also, the observed increase in the proportion of B-cells in peripheral blood in response to immunization was greater in the HiAMIR-phenotype animals. It is expected that identifying leukocyte population profiles associated with immune response phenotypes will improve our ability to identify animals with enhanced overall immune responsiveness.
authors.affiliation: Dairy Science and Technology, AgResearch Limited, Ruakura Research Centre, Hamilton, New Zealand. brad.hine@agresearch.co.nz
authors.forename: Brad C
authors.initials: BC
authors.lastname: Hine
authors.forename: Shannon L
authors.initials: SL
authors.lastname: Cartwright
authors.forename: Bonnie A
authors.initials: BA
authors.lastname: Mallard
mesh_terms: D000818:Animals; D002170:Canada; D002417:Cattle / Q000097:blood / Q000276:immunology*; D005260:Female; D005434:Flow Cytometry / Q000662:veterinary; D007111:Immunity, Cellular / Q000276:immunology*; D007074:Immunoglobulin G / Q000097:blood / Q000276:immunology*; D016130:Immunophenotyping / Q000662:veterinary; D007963:Leukocytes, Mononuclear / Q000166:cytology* / Q000276:immunology; D010641:Phenotype; D011247:Pregnancy
chemical_list: D007074:Immunoglobulin G