title: Differentiation of cancer cell type and phenotype using quantum dot-gold nanoparticle sensor arrays.
abstract: We demonstrate rapid and efficient sensing of mammalian cell types and states using nanoparticle-based sensor arrays. These arrays are comprised of cationic quantum dots (QDs) and gold nanoparticles (AuNPs) that interact with cell surfaces to generate distinguishable fluorescence responses based on cell surface signatures. The use of QDs as the recognition elements as well as the signal transducers presents the potential for direct visualization of selective cell surface interactions. Notably, this sensor is unbiased, precluding the requirement of pre-knowledge of cell state biomarkers and thus providing a general approach for phenotypic profiling of cell states, with additional potential for imaging applications.
authors.affiliation: Department of Chemistry, University of Massachusetts, Amherst, MA 01003, USA.
authors.forename: Qian
authors.initials: Q
authors.lastname: Liu
authors.forename: Yi-Cheun
authors.initials: YC
authors.lastname: Yeh
authors.forename: Subinoy
authors.initials: S
authors.lastname: Rana
authors.forename: Ying
authors.initials: Y
authors.lastname: Jiang
authors.forename: Lin
authors.initials: L
authors.lastname: Guo
authors.forename: Vincent M
authors.initials: VM
authors.lastname: Rotello
mesh_terms: D015374:Biosensing Techniques / Q000379:methods*; D002454:Cell Differentiation / Q000502:physiology; D006046:Gold / Q000737:chemistry*; D006367:HeLa Cells; D056945:Hep G2 Cells; D006801:Humans; D061986:MCF-7 Cells; D053768:Metal Nanoparticles / Q000737:chemistry*; D009369:Neoplasms / Q000737:chemistry / Q000473:pathology*; D010641:Phenotype; D045663:Quantum Dots; D013499:Surface Properties
chemical_list: D006046:Gold