title: Negative regulation of myeloid-derived suppressor cells in cancer.
abstract: Myeloid-derived suppressor cells (MDSC) are a heterogeneous population of immature myeloid cells with suppressive function on immune response. In this review, we discuss recent studies about mechanisms of expansion and suppressive function of MDSCs during inflammation, infection and autoimmune diseases, as well as pro-angiogenic and pro-metastatic functions of these cells in tumor development. Further, we focus on novel studies of MDSCs and therapeutic approaches to eliminate these cells in cancer.
authors.affiliation: National Cancer Institute, National Institutes of Health, Frederick, Maryland 21702, USA.
authors.forename: Peng
authors.initials: P
authors.lastname: Qu
authors.forename: Kimberly C
authors.initials: KC
authors.lastname: Boelte
authors.forename: P Charles
authors.initials: PC
authors.lastname: Lin
mesh_terms: D000818:Animals; D015703:Antigens, CD / Q000235:genetics / Q000276:immunology; D002450:Cell Communication / Q000235:genetics / Q000276:immunology; D049109:Cell Proliferation; D003713:Dendritic Cells / Q000276:immunology / Q000378:metabolism* / Q000473:pathology; D006801:Humans; D007249:Inflammation / Q000276:immunology / Q000378:metabolism / Q000473:pathology*; D051379:Mice; D023461:Myeloid Progenitor Cells / Q000276:immunology / Q000378:metabolism* / Q000473:pathology; D009363:Neoplasm Proteins / Q000235:genetics / Q000276:immunology*; D009369:Neoplasms / Q000276:immunology / Q000378:metabolism / Q000473:pathology*; D015398:Signal Transduction / Q000235:genetics / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology / Q000378:metabolism* / Q000473:pathology; D019139:Tumor Escape / Q000235:genetics
chemical_list: D015703:Antigens, CD; D009363:Neoplasm Proteins