title: New horizons for antiviral drug discovery from virus-host protein interaction networks.
abstract: Viruses are recurrent socio economical and health problems each year worldwide. Current drugs are mainly directed against viral components and select resistant strains that urge the need to develop new antiviral therapeutics. High-throughput screening technologies now allow to draw comprehensive genome-wide maps of physical and genetic virus-host interactions. This has been done recently for several viruses such as HIV, HCV, DENV and FLUAV and revealed a wealth of potential antiviral cellular targets. Systems-level analysis of virus-host protein networks and subnetworks begins to uncover several specific points of intervention for a human centered drug development. We present here this new paradigm in antiviral drug discovery together with the first promising antiviral molecules.
authors.affiliation: Université de Lyon, INSERM, U851, Hospices Civils de Lyon, Hôpital de la Croix-Rousse, Laboratoire de virologie, 21 Avenue Tony Garnier, Lyon, F-69007, France.
authors.forename: Benoît
authors.initials: B
authors.lastname: de Chassey
authors.forename: Laurène
authors.initials: L
authors.lastname: Meyniel-Schicklin
authors.forename: Anne
authors.initials: A
authors.lastname: Aublin-Gex
authors.forename: Patrice
authors.initials: P
authors.lastname: André
authors.forename: Vincent
authors.initials: V
authors.lastname: Lotteau
mesh_terms: D000818:Animals; D000998:Antiviral Agents / Q000494:pharmacology*; D055808:Drug Discovery; D054884:Host-Pathogen Interactions / Q000187:drug effects; D006801:Humans; D060066:Protein Interaction Maps / Q000187:drug effects*; D014777:Virus Diseases / Q000235:genetics / Q000378:metabolism* / Q000821:virology; D014780:Viruses / Q000187:drug effects* / Q000235:genetics / Q000378:metabolism
chemical_list: D000998:Antiviral Agents