title: [Correlation of recurrent pregnancy loss with sperm parameters and sperm DNA fragmentation].
abstract: OBJECTIVE
  To evaluate and compare standard sperm parameters and sperm DNA fragmentation in seminal ejaculates from men whose partners had a history of recurrent pregnancy loss (RPL) and a control group of men who had recently established their fertility.
  
  
  METHODS
  Semen samples from 85 patients with a history of RPL and 20 men with proven fertility were analyzed according to World Health Organization guidelines. Sperm DNA fragmentation was detected by sperm chromatin dispersion test (SCD).
  
  
  RESULTS
  A significant difference (P< 0.05) was observed in sperm motility but not other parameters between the two groups. The mean number of sperm cells with fragmented DNA, represented as DNA fragmentation index, was significantly increased in the RPL group [(34.99± 14.62)%] compared with controls [(10.82± 4.80)%].
  
  
  CONCLUSIONS
  This study has indicated that sperm from men with a history of RPL have a higher incidence of DNA damage and poor motility compared with fertile males.
authors.affiliation: Department of Urology, Chongqing Medical University, Chongqing, People's Republic of China.
authors.forename: Ying-jun
authors.initials: YJ
authors.lastname: Wang
authors.forename: Da-wen
authors.initials: DW
authors.lastname: Li
authors.forename: Wei-li
authors.initials: WL
authors.lastname: Zhang
authors.forename: Rong-qiu
authors.initials: RQ
authors.lastname: Zhang
authors.forename: Gao-neng
authors.initials: GN
authors.lastname: Wang
authors.forename: Rong-rong
authors.initials: RR
authors.lastname: Zhang
mesh_terms: D000026:Abortion, Habitual / Q000209:etiology* / Q000235:genetics; D000328:Adult; D004249:DNA Damage; D053938:DNA Fragmentation; D005260:Female; D006801:Humans; D008297:Male; D011247:Pregnancy; D013081:Sperm Motility