title: Synthesis and in vitro and in vivo anticancer activity of novel 3-methyl-5H-isoxazolo[5',4':5,6]pyrido[2,3-b]indoles.
abstract: A series of novel isoxazolo[5',4':5,6]pyrido[2,3-b]indoles 7a-h were synthesized and tested for their in vitro and in vivo anticancer activities. The analogs 7d and 7g have shown potential anticancer activity as compared with the reference compound Cisplatin.
authors.affiliation: Department of Chemistry, Kakatiya University, Warangal 506 009, AP, India. rajanarendareligeti@gmail.com
authors.forename: E
authors.initials: E
authors.lastname: Rajanarendar
authors.forename: K
authors.initials: K
authors.lastname: Govardhan Reddy
authors.forename: S
authors.initials: S
authors.lastname: Ramakrishna
authors.forename: M
authors.initials: M
authors.lastname: Nagi Reddy
authors.forename: B
authors.initials: B
authors.lastname: Shireesha
authors.forename: G
authors.initials: G
authors.lastname: Durgaiah
authors.forename: Y N
authors.initials: YN
authors.lastname: Reddy
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D002945:Cisplatin / Q000494:pharmacology; D006801:Humans; D007211:Indoles / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D020128:Inhibitory Concentration 50; D007555:Isoxazoles / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D008297:Male; D051379:Mice; D015394:Molecular Structure; D011728:Pyridones / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology
chemical_list: D000970:Antineoplastic Agents; D007211:Indoles; D007555:Isoxazoles; D011728:Pyridones; D002945:Cisplatin