title: Extraosseous plasmacytoma with an aggressive course occurring solely in the CNS.
abstract: Extraosseous (extramedullary) plasmacytoma is a relatively indolent neoplasm that constitutes 3-5% of all plasma cell neoplasms. Rare cases have been reported to truly occur in the CNS and not as an extension from a nasal lesion. EBV expression in plasma cell neoplasms has been reported in very few cases that are mainly post-transplant or occurring in severely immunosuppressed patients. We report a case of extraosseous plasmacytoma with an aggressive course in an HIV-positive individual that occurred solely in the CNS, showing EBV expression by in situ hybridization, and presenting as an intraparenchymal mass as well as in the CSF.
authors.affiliation: Department of Pathology & Laboratory Medicine, University of California, Irvine, Irvine, California, USA.
authors.forename: William
authors.initials: W
authors.lastname: Wu
authors.forename: Whitney
authors.initials: W
authors.lastname: Pasch
authors.forename: Xiaohui
authors.initials: X
authors.lastname: Zhao
authors.forename: Sherif A
authors.initials: SA
authors.lastname: Rezk
mesh_terms: D000328:Adult; D001921:Brain / Q000473:pathology; D016543:Central Nervous System Neoplasms / Q000188:drug therapy / Q000473:pathology*; D020031:Epstein-Barr Virus Infections / Q000150:complications / Q000473:pathology; D017809:Fatal Outcome; D006679:HIV Seropositivity / Q000150:complications; D006801:Humans; D007150:Immunohistochemistry; D017403:In Situ Hybridization; D008279:Magnetic Resonance Imaging; D008297:Male; D010954:Plasmacytoma / Q000188:drug therapy / Q000473:pathology*; D014057:Tomography, X-Ray Computed