title: Epstein-Barr virus-associated smooth muscle tumor-report of 3 tumors including 1 intracerebral case with a prominent intratumoral B-lymphocytic component and plasma cells.
abstract: Three Epstein-Barr virus-associated smooth muscle tumors (intracranial, endobronchial, and paraspinal) in 2 patients are presented. The patient with the intracranial tumor had no concurrent or previous manifestation of this neoplasm and was immunosuppressed because of a renal transplant. The other patient had AIDS and radiologic evidence of involvement of multiple other sites. Although mitotic activity was present, none of the tumors displayed any high-grade malignant histologic features. All tumors were strongly positive for smooth muscle actin and variably expressed h-caldesmon. Desmin was negative in all 3 tumors. The intracranial tumor was associated with prominent intracerebral edema and displayed, in addition to a prominent intratumoral T-cell component, a hitherto unreported component of prominent intratumoral B cells and plasma cells.
authors.affiliation: Department of Pathology, National University Health System, Singapore. fredrikpetersson@live.se
authors.forename: Fredrik
authors.initials: F
authors.lastname: Petersson
mesh_terms: D000199:Actins / Q000378:metabolism; D000328:Adult; D001402:B-Lymphocytes / Q000378:metabolism / Q000473:pathology*; D014408:Biomarkers, Tumor / Q000378:metabolism; D001932:Brain Neoplasms / Q000175:diagnosis* / Q000453:epidemiology / Q000473:pathology; D001984:Bronchial Neoplasms / Q000175:diagnosis* / Q000453:epidemiology / Q000473:pathology; D002148:Calmodulin-Binding Proteins / Q000378:metabolism; D015897:Comorbidity; D020031:Epstein-Barr Virus Infections / Q000453:epidemiology; D005260:Female; D006801:Humans; D016867:Immunocompromised Host; D008297:Male; D008875:Middle Aged; D010950:Plasma Cells / Q000378:metabolism / Q000473:pathology*; D018235:Smooth Muscle Tumor / Q000175:diagnosis* / Q000453:epidemiology / Q000473:pathology; D013125:Spinal Neoplasms / Q000175:diagnosis* / Q000453:epidemiology / Q000473:pathology
chemical_list: D000199:Actins; D014408:Biomarkers, Tumor; D002148:Calmodulin-Binding Proteins