title: Advanced vulvar apocrine carcinoma expressing estrogen receptors that responds to tamoxifen therapy.
abstract: Primary vulvar carcinoma is rare and thought to arise from either anogenital mammary-like glands or native apocrine sweat glands. The diagnosis is predominantly based on tumor morphology with supportive evidence from immunohistochemical staining and exclusion of a primary breast carcinoma. The primary modality of treatment is surgery, while optimal managment of advanced disease is unclear. We present the case of a lady who had metastatic recurrent apocrine carcinoma expressing estrogen receptors, who had a complete response assessed by PET-CT scanning after 7 months of tamoxifen therapy. The report includes a discussion of the histological diagnosis and assessment of response to treatment by PET-CT scanning.
authors.affiliation: UCL Cancer Institute, Paul O'Gorman Building, University College London, 72 Huntley Street, London, WC1E 6DD, UK. drgoldstein05@yahoo.co.uk
authors.forename: Robert
authors.initials: R
authors.lastname: Goldstein
authors.forename: Catherine M
authors.initials: CM
authors.lastname: Stefanato
authors.forename: Victoria
authors.initials: V
authors.lastname: Warbey
authors.forename: Mark
authors.initials: M
authors.lastname: Harries
mesh_terms: D000368:Aged; D018931:Antineoplastic Agents, Hormonal / Q000627:therapeutic use*; D002277:Carcinoma / Q000000981:diagnostic imaging* / Q000188:drug therapy / Q000378:metabolism / Q000556:secondary; D005260:Female; D006801:Humans; D009376:Neoplasms, Hormone-Dependent / Q000000981:diagnostic imaging* / Q000188:drug therapy / Q000378:metabolism / Q000473:pathology; D011859:Radiography; D011960:Receptors, Estrogen / Q000378:metabolism*; D012878:Skin Neoplasms / Q000000981:diagnostic imaging* / Q000188:drug therapy / Q000378:metabolism / Q000556:secondary; D013629:Tamoxifen / Q000627:therapeutic use*; D016896:Treatment Outcome; D014846:Vulvar Neoplasms / Q000000981:diagnostic imaging* / Q000188:drug therapy / Q000378:metabolism / Q000473:pathology
chemical_list: D018931:Antineoplastic Agents, Hormonal; D011960:Receptors, Estrogen; D013629:Tamoxifen