title: [Microbiocenosis and activity of the inflammatory process in the colon of the patients with chronic cardiac failure].
abstract: The aim of this work was to study colonic microbiocenosis, endotoxin level, intensity of systemic inflammation and the state of matrix metalloproteinase (MMP) system and MMP tissue inhibitors (TIMP) in 75 patients with post-infarction cardiosclerosis at different stages of chronic cardiac failure (CCF). The patients were examined by clinical, echocardiographic and laboratory methods including bacteriological analysis of feces and measurement of amino-terminal brain natriuruetic peptide, endotoxin, TNF-alpha, MMP-9, and TIMP-4. The progress of CCF was shown to be associated with increasing colonic dysbiosis, endotoxin and TNF-alpha levels, disbalance in the MMO and TIMP systems.
authors.forename: E N
authors.initials: EN
authors.lastname: Egorova
authors.forename: M I
authors.initials: MI
authors.lastname: Kuz'mina
authors.forename: V V
authors.initials: VV
authors.lastname: Mazur
authors.forename: M N
authors.initials: MN
authors.lastname: Kalinkin
authors.forename: E S
authors.initials: ES
authors.lastname: Mazur
mesh_terms: D002908:Chronic Disease; D003106:Colon / Q000201:enzymology / Q000382:microbiology* / Q000473:pathology*; D015897:Comorbidity; D016207:Cytokines / Q000097:blood; D004731:Endotoxins / Q000097:blood; D005260:Female; D006333:Heart Failure / Q000201:enzymology / Q000382:microbiology* / Q000473:pathology*; D006801:Humans; D018836:Inflammation Mediators / Q000097:blood / Q000378:metabolism / Q000502:physiology*; D008297:Male; D020780:Matrix Metalloproteinase 9 / Q000097:blood; D008875:Middle Aged; D012720:Severity of Illness Index; D019714:Tissue Inhibitor of Metalloproteinases / Q000097:blood; D014409:Tumor Necrosis Factor-alpha / Q000097:blood
chemical_list: D016207:Cytokines; D004731:Endotoxins; D018836:Inflammation Mediators; D019714:Tissue Inhibitor of Metalloproteinases; D014409:Tumor Necrosis Factor-alpha; D020780:Matrix Metalloproteinase 9