title: Role of β-catenin expression in paediatric mesenchymal lesions: a tissue microarray-based immunohistochemical study.
abstract: Beta-catenin is a major protein in the Wnt signalling pathway. Although it has been studied in various types of carcinoma, little is known about its expression in mesenchymal tumours. In this study 41 specimens of a variety of mesenchymal childhood tumours were compared to 24 samples of the corresponding adult tumours to assess the diagnostic value of nuclear β-catenin expression using tissue microarray-based immunohistochemistry. Similar to adult sarcoma and fibromatosis, β-catenin was not expressed in the majority of childhood sarcomas, and its nuclear translocation was detected in paediatric fibromatosis; non-negligible levels of nuclear staining in other tumour types demonstrate Wnt pathway activation in mesenchymal neoplasms of childhood and adolescence.
authors.affiliation: Department of Surgical Sciences, Institute of Pathology and Cytopathology, University of Foggia, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Santoro
authors.forename: G
authors.initials: G
authors.lastname: Pannone
authors.forename: M E
authors.initials: ME
authors.lastname: Errico
authors.forename: D
authors.initials: D
authors.lastname: Bifano
authors.forename: G
authors.initials: G
authors.lastname: Lastilla
authors.forename: P
authors.initials: P
authors.lastname: Bufo
authors.forename: C
authors.initials: C
authors.lastname: Loreto
authors.forename: V
authors.initials: V
authors.lastname: Donofrio
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002648:Child; D002675:Child, Preschool; D005260:Female; D005786:Gene Expression Regulation; D006801:Humans; D007150:Immunohistochemistry; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D008648:Mesoderm / Q000473:pathology*; D008875:Middle Aged; D012015:Reference Standards; D012509:Sarcoma / Q000473:pathology*; D046888:Tissue Array Analysis; D051176:beta Catenin / Q000235:genetics / Q000378:metabolism*
chemical_list: D051176:beta Catenin