title: Lack of association between BST1 polymorphisms and sporadic Parkinson's disease in a Japanese population.
abstract: Several genome-wide association studies and case-control studies have investigated the relationships between single nucleotide polymorphisms (SNPs) in the BST1 gene and Parkinson's disease (PD), but the results have been inconsistent. We examined the relationships between SNPs rs11931532, rs12645693, and rs11724635 and the risk of sporadic PD in Japan. Included were 229 cases within 6years of onset of PD as defined according to the UK PD Society Brain Bank clinical diagnostic criteria. Controls were 357 inpatients and outpatients without neurodegenerative disease. SNPs rs11931532 and rs12645693 were not significantly related to sporadic PD. Compared with a reference group of subjects with the CC genotype of SNP rs11724635, those with the AA genotype had a marginally significantly increased risk of sporadic PD: the adjusted OR was 1.57 (95% CI: 0.95-2.61, P=0.08). No significant interactions were found between BST1 SNP rs11724635 and smoking or caffeine intake with respect to sporadic PD. The current study failed to detect significant relationships between BST1 SNPs rs11931532, rs12645693, and rs11724635 and sporadic PD; however, the relationship between SNP rs11724635 and sporadic PD was of borderline significance. We do not find evidence for interactions between smoking or caffeine intake and SNP rs11724635 affecting sporadic PD.
authors.affiliation: Department of Preventive Medicine and Public Health, Faculty of Medicine, Fukuoka University, Japan. miyake-y@fukuoka-u.ac.jp
authors.forename: Yoshihiro
authors.initials: Y
authors.lastname: Miyake
authors.forename: Keiko
authors.initials: K
authors.lastname: Tanaka
authors.forename: Wakaba
authors.initials: W
authors.lastname: Fukushima
authors.forename: Chikako
authors.initials: C
authors.lastname: Kiyohara
authors.forename: Satoshi
authors.initials: S
authors.lastname: Sasaki
authors.forename: Yoshio
authors.initials: Y
authors.lastname: Tsuboi
authors.forename: Tatsuo
authors.initials: T
authors.lastname: Yamada
authors.forename: Tomoko
authors.initials: T
authors.lastname: Oeda
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Shimada
authors.forename: Nobutoshi
authors.initials: N
authors.lastname: Kawamura
authors.forename: Nobutaka
authors.initials: N
authors.lastname: Sakae
authors.forename: Hidenao
authors.initials: H
authors.lastname: Fukuyama
authors.forename: Yoshio
authors.initials: Y
authors.lastname: Hirota
authors.forename: Masaki
authors.initials: M
authors.lastname: Nagai
mesh_terms: D036541:ADP-ribosyl Cyclase / Q000235:genetics*; D017668:Age of Onset; D000368:Aged; D015703:Antigens, CD / Q000235:genetics*; D044466:Asian People / Q000235:genetics; D002110:Caffeine; D016022:Case-Control Studies; D005260:Female; D058851:GPI-Linked Proteins / Q000235:genetics; D059647:Gene-Environment Interaction; D020022:Genetic Predisposition to Disease; D006801:Humans; D007564:Japan / Q000453:epidemiology; D015810:Linkage Disequilibrium; D008297:Male; D008875:Middle Aged; D010300:Parkinson Disease / Q000208:ethnology / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D012306:Risk; D012907:Smoking / Q000235:genetics; D011795:Surveys and Questionnaires
chemical_list: D015703:Antigens, CD; D058851:GPI-Linked Proteins; D002110:Caffeine; D036541:ADP-ribosyl Cyclase; C087521:ADP-ribosyl cyclase 2