title: Outcomes of fusion for lateral atlantoaxial osteoarthritis: meta-analysis and review of literature.
abstract: OBJECTIVE
  Atlantoaxial osteoarthritis (AAOA) is an underrecognized source of neck pain, limitation of range of motion, and cervicogenic headaches. When conservative treatments such as facet injections fail, fusion may be indicated. We reviewed published series describing posterior fusions for atlantoaxial osteoarthritis of the facet joints.
  
  
  METHODS
  Online databases were searched for English-language articles describing the diagnosis and treatment of AAOA. Twenty-three studies reporting on 246 patients treated with posterior fusion for lateral AAOA fulfilled inclusion criteria. Standard statistical and formal meta-analytic techniques were used to assess outcomes.
  
  
  RESULTS
  All studies provided class III evidence. The 30-day perioperative mortality was 1.2% and neurologic injury did not occur. Patients were followed for a mean of nearly 5 years. Fusion was successful in 98% of patients with a single operation and with 99.5% of patients after revision surgery. Intractable preoperative neck pain either resolved completely or improved in 97.7% of patients. Using meta-analytic techniques, the point estimate for improvement or resolution of pain was 92.6% (confidence interval = 86.8%-96.0%) and the rate of arthrodesis for AAOA was 92.2% (confidence interval = 85.6%-95.9%) and there were no differences among the various techniques used for fusion. Operative complications were few.
  
  
  CONCLUSIONS
  Posterior C1-2 fusion is a safe and effective treatment option for patients with intractable neck pain secondary to lateral AAOA. Modern fusion options offer a high rate of arthrodesis and low risk of morbidity if conservative therapies fail to provide adequate pain relief.
authors.affiliation: Neurosurgical Care, LLC., Royersford, Pennsylvania, New York, New York, USA. Electronic address: robertelliottmd@gmail.com.
authors.forename: Robert E
authors.initials: RE
authors.lastname: Elliott
authors.forename: Omar
authors.initials: O
authors.lastname: Tanweer
authors.forename: Michael L
authors.initials: ML
authors.lastname: Smith
authors.forename: Anthony
authors.initials: A
authors.lastname: Frempong-Boadu
mesh_terms: D000328:Adult; D000368:Aged; D001174:Arthrodesis / Q000379:methods; D001268:Atlanto-Axial Joint / Q000473:pathology / Q000601:surgery*; D016001:Confidence Intervals; D003627:Data Interpretation, Statistical; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D019547:Neck Pain / Q000209:etiology / Q000628:therapy; D055013:Osteoarthritis, Spine / Q000473:pathology / Q000601:surgery*; D012086:Reoperation; D013123:Spinal Fusion / Q000379:methods* / Q000401:mortality; D016896:Treatment Outcome; D021801:Zygapophyseal Joint / Q000473:pathology / Q000601:surgery