title: [Ways of apoptosis development in human lymphocytes, induced by UV-irradiation].
abstract: The level of DNA damage and cytochrome c content in human lymphocytes in the dynamics of apoptosis induced by UV-light (240-390 nm) at doses of 151, 1510 and 3020 J/m2 is studied. DNA fragmentation is revealed in 20 h after UV-irradiation of lymphocytes at doses mentioned above. It is shown that DNA damages (single strand breaks) appear immediately after UV-irradiation of lymphocytes at doses of 1510 and 3020 J/m2 (comets of C1 type) and reach their maximum 6 h after cell modification (comets of C2 and C3 types). It is concluded that p53-dependent and receptor caspase pathways are involved in apoptosis development in the human lymphocytes, modified after UV-irradiation.
authors.forename: M A
authors.initials: MA
authors.lastname: Nakvasina
authors.forename: M S
authors.initials: MS
authors.lastname: Trubitsyna
authors.forename: E V
authors.initials: EV
authors.lastname: Solov'eva
authors.forename: V G
authors.initials: VG
authors.lastname: Artiukhov
mesh_terms: D017209:Apoptosis / Q000528:radiation effects*; D053148:Caspase 3 / Q000378:metabolism; D002478:Cells, Cultured; D045304:Cytochromes c / Q000378:metabolism; D004247:DNA / Q000528:radiation effects*; D053904:DNA Breaks, Single-Stranded / Q000528:radiation effects*; D006801:Humans; D008214:Lymphocytes / Q000528:radiation effects; D053858:Metabolic Networks and Pathways / Q000528:radiation effects; D016159:Tumor Suppressor Protein p53 / Q000378:metabolism; D014466:Ultraviolet Rays; D019014:fas Receptor / Q000378:metabolism
chemical_list: C495901:TP53 protein, human; D016159:Tumor Suppressor Protein p53; D019014:fas Receptor; D045304:Cytochromes c; D004247:DNA; D053148:Caspase 3