title: Synthesis, characterization, biological evaluation and QSAR studies of 11-p-substituted phenyl-12-phenyl-11a,12-dihydro-11H-indeno[2,1-c][1,5]benzothiazepines as potential antimicrobial agents.
abstract: A novel series of 11-p-substituted phenyl-12-phenyl-11a,12-dihydro-11H-indeno[2,1-c][1,5]benzothiazepines (3) has been synthesized and screened for their antimicrobial activity against Gram-positive (Bacillus subtilis and Staphylococcus aureus) and Gram-negative (Escherichia coli and Pseudomonas aeruginosa) bacteria and fungi (Aspergillus fumigates and Candida albicans). The antimicrobial evaluation data indicated that the compounds, 3d, 3g, 3h, 3k-3p exhibited very promising antibacterial activity and the derivatives 3k, 3l, 3o and 3p exhibited high antifungal activity. The QSAR studies carried out to find out the correlation between the antimicrobial activity and physicochemical properties of synthesized benzothiazepines (3) indicated the predominance of electronic parameters in describing their antimicrobial activity.
authors.affiliation: Department of Chemistry, Guru Jambheshwar University of Science and Technology, Hisar 125001, Haryana, India. satbir_mor@yahoo.co.in
authors.forename: Satbir
authors.initials: S
authors.lastname: Mor
authors.forename: Preeti
authors.initials: P
authors.lastname: Pahal
authors.forename: Balasubramanian
authors.initials: B
authors.lastname: Narasimhan
mesh_terms: D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D000935:Antifungal Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D001232:Aspergillus fumigatus / Q000187:drug effects / Q000254:growth & development; D001412:Bacillus subtilis / Q000187:drug effects / Q000254:growth & development; D002176:Candida albicans / Q000187:drug effects / Q000254:growth & development; D004926:Escherichia coli / Q000187:drug effects / Q000254:growth & development; D008826:Microbial Sensitivity Tests; D050296:Microbial Viability / Q000187:drug effects; D015394:Molecular Structure; D011550:Pseudomonas aeruginosa / Q000187:drug effects / Q000254:growth & development; D021281:Quantitative Structure-Activity Relationship; D013211:Staphylococcus aureus / Q000187:drug effects / Q000254:growth & development; D013841:Thiazepines / Q000138:chemical synthesis* / Q000494:pharmacology
chemical_list: D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D013841:Thiazepines