title: Genome-wide association study in Chinese men identifies two new prostate cancer risk loci at 9q31.2 and 19q13.4.
abstract: Prostate cancer risk-associated variants have been reported in populations of European descent, African-Americans and Japanese using genome-wide association studies (GWAS). To systematically investigate prostate cancer risk-associated variants in Chinese men, we performed the first GWAS in Han Chinese. In addition to confirming several associations reported in other ancestry groups, this study identified two new risk-associated loci for prostate cancer on chromosomes 9q31.2 (rs817826, P = 5.45 × 10(-14)) and 19q13.4 (rs103294, P = 5.34 × 10(-16)) in 4,484 prostate cancer cases and 8,934 controls. The rs103294 marker at 19q13.4 is in strong linkage equilibrium with a 6.7-kb germline deletion that removes the first six of seven exons in LILRA3, a gene regulating inflammatory response, and was significantly associated with the mRNA expression of LILRA3 in T cells (P < 1 × 10(-4)). These findings may advance the understanding of genetic susceptibility to prostate cancer.
authors.affiliation: Fudan Institute of Urology, Huashan Hospital, Fudan University, Shanghai, China.
authors.forename: Jianfeng
authors.initials: J
authors.lastname: Xu
authors.forename: Zengnan
authors.initials: Z
authors.lastname: Mo
authors.forename: Dingwei
authors.initials: D
authors.lastname: Ye
authors.forename: Meilin
authors.initials: M
authors.lastname: Wang
authors.forename: Fang
authors.initials: F
authors.lastname: Liu
authors.forename: Guangfu
authors.initials: G
authors.lastname: Jin
authors.forename: Chuanliang
authors.initials: C
authors.lastname: Xu
authors.forename: Xiang
authors.initials: X
authors.lastname: Wang
authors.forename: Qiang
authors.initials: Q
authors.lastname: Shao
authors.forename: Zhiwen
authors.initials: Z
authors.lastname: Chen
authors.forename: Zhihua
authors.initials: Z
authors.lastname: Tao
authors.forename: Jun
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authors.lastname: Qi
authors.forename: Fangjian
authors.initials: F
authors.lastname: Zhou
authors.forename: Zhong
authors.initials: Z
authors.lastname: Wang
authors.forename: Yaowen
authors.initials: Y
authors.lastname: Fu
authors.forename: Dalin
authors.initials: D
authors.lastname: He
authors.forename: Qiang
authors.initials: Q
authors.lastname: Wei
authors.forename: Jianming
authors.initials: J
authors.lastname: Guo
authors.forename: Denglong
authors.initials: D
authors.lastname: Wu
authors.forename: Xin
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authors.lastname: Gao
authors.forename: Jianlin
authors.initials: J
authors.lastname: Yuan
authors.forename: Gongxian
authors.initials: G
authors.lastname: Wang
authors.forename: Yong
authors.initials: Y
authors.lastname: Xu
authors.forename: Guozeng
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authors.lastname: Wang
authors.forename: Haijun
authors.initials: H
authors.lastname: Yao
authors.forename: Pei
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authors.lastname: Dong
authors.forename: Yang
authors.initials: Y
authors.lastname: Jiao
authors.forename: Mo
authors.initials: M
authors.lastname: Shen
authors.forename: Jin
authors.initials: J
authors.lastname: Yang
authors.forename: Jun
authors.initials: J
authors.lastname: Ou-Yang
authors.forename: Haowen
authors.initials: H
authors.lastname: Jiang
authors.forename: Yao
authors.initials: Y
authors.lastname: Zhu
authors.forename: Shancheng
authors.initials: S
authors.lastname: Ren
authors.forename: Zhengdong
authors.initials: Z
authors.lastname: Zhang
authors.forename: Changjun
authors.initials: C
authors.lastname: Yin
authors.forename: Xu
authors.initials: X
authors.lastname: Gao
authors.forename: Bo
authors.initials: B
authors.lastname: Dai
authors.forename: Zhibin
authors.initials: Z
authors.lastname: Hu
authors.forename: Yajun
authors.initials: Y
authors.lastname: Yang
authors.forename: Qijun
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authors.lastname: Wu
authors.forename: Hongyan
authors.initials: H
authors.lastname: Chen
authors.forename: Peng
authors.initials: P
authors.lastname: Peng
authors.forename: Ying
authors.initials: Y
authors.lastname: Zheng
authors.forename: Xiaodong
authors.initials: X
authors.lastname: Zheng
authors.forename: Yongbing
authors.initials: Y
authors.lastname: Xiang
authors.forename: Jirong
authors.initials: J
authors.lastname: Long
authors.forename: Jian
authors.initials: J
authors.lastname: Gong
authors.forename: Rong
authors.initials: R
authors.lastname: Na
authors.forename: Xiaoling
authors.initials: X
authors.lastname: Lin
authors.forename: Hongjie
authors.initials: H
authors.lastname: Yu
authors.forename: Zhong
authors.initials: Z
authors.lastname: Wang
authors.forename: Sha
authors.initials: S
authors.lastname: Tao
authors.forename: Junjie
authors.initials: J
authors.lastname: Feng
authors.forename: Jishan
authors.initials: J
authors.lastname: Sun
authors.forename: Wennuan
authors.initials: W
authors.lastname: Liu
authors.forename: Ann
authors.initials: A
authors.lastname: Hsing
authors.forename: Jianyu
authors.initials: J
authors.lastname: Rao
authors.forename: Qiang
authors.initials: Q
authors.lastname: Ding
authors.forename: Fredirik
authors.initials: F
authors.lastname: Wiklund
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authors.initials: H
authors.lastname: Gronberg
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authors.initials: XO
authors.lastname: Shu
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authors.lastname: Zheng
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authors.lastname: Shi
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authors.lastname: Lu
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authors.lastname: Zhang
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authors.lastname: Sun
authors.forename: S Lilly
authors.initials: SL
authors.lastname: Zheng
authors.forename: Yinghao
authors.initials: Y
authors.lastname: Sun
mesh_terms: D044466:Asian People; D002888:Chromosomes, Human, Pair 19; D002899:Chromosomes, Human, Pair 9; D045643:DNA Repair Enzymes / Q000235:genetics; D004268:DNA-Binding Proteins / Q000235:genetics; D017353:Gene Deletion; D020022:Genetic Predisposition to Disease; D055106:Genome-Wide Association Study; D006801:Humans; D000090062:Kruppel-Like Factor 4; D051741:Kruppel-Like Transcription Factors / Q000235:genetics; D008297:Male; D020641:Polymorphism, Single Nucleotide; D011471:Prostatic Neoplasms / Q000235:genetics*; D011971:Receptors, Immunologic / Q000235:genetics*; D012307:Risk Factors
chemical_list: D004268:DNA-Binding Proteins; D000090062:Kruppel-Like Factor 4; D051741:Kruppel-Like Transcription Factors; C530062:LILRA3 protein, human; C513287:RAD23B protein, human; D011971:Receptors, Immunologic; D045643:DNA Repair Enzymes