title: Palladium-catalyzed substitution of (coumarinyl)methyl acetates with C-, N-, and S-nucleophiles.
abstract: The palladium-catalyzed nucleophilic substitution of (coumarinyl)methyl acetates is described. The reaction proceeds though a palladium π-benzyl-like complex and allows for many different types of C-, N-, and S-nucleophiles to be regioselectively added to the biologically active coumarin motif. This new method was utilized to prepare a 128-membered library of aminated coumarins for biological screening.
authors.affiliation: Department of Chemistry, University of Kansas, 1251 Wescoe Hall Drive, Lawrence, KS 66045-7528, USA ; KU Chemical Methodologies and Library Development Center of Excellence, University of Kansas, 1501 Wakarusa Drive, Lawrence, Kansas 66047, USA.
authors.forename: Kalicharan
authors.initials: K
authors.lastname: Chattopadhyay
authors.forename: Erik
authors.initials: E
authors.lastname: Fenster
authors.forename: Alexander J
authors.initials: AJ
authors.lastname: Grenning
authors.forename: Jon A
authors.initials: JA
authors.lastname: Tunge