title: Patients with autoimmune thyroiditis. Prevalence of benign lymphadenopathy.
abstract: The prevalence of cervical lymphadenopathy in autoimmune thyroiditis (AIT) patients is actually unknown. The aim of the study was the detailed retrospective evaluation of 6 index-patients with lymphadenopathy in Robbins level VI and a prospective study with high resolution ultrasound of lymphadenopathy in AIT patients compared with controls in all compartments of the neck, accessible to sonographic evaluation.
  
  
  METHODS
  The retrospective study comprises six patients with AIT, evaluated for enlarged Robbins level VI-LN. We report the findings of fine-needle aspiration Cytology, clonal analysis, histology, and serological testing. The prospective study evaluated the prevalence of lymphadenopathy in 49 consecutive patients with AIT (group 1) and 49 consecutive patients with normal thyroids or nontoxic goiter (group 2).
  
  
  RESULTS
  In the retrospective study, cytology of paratracheal LN revealed reactive lymphoid hyperplasia in 5/6 of the cases and a centroblastic lymphoma in one patient. The presence of monoclonal lymphatic cells was excluded in 5/6 patients and proven in 1/6 patients. Actual viral-infections were ruled out. In the prospective study AIT-patients showed significantly more enlarged LN in Robbins level II-IV and VI compared to controls. We found no correlation between lymphadenopathy, age, thyroid volume and nodularity, or autoantibody levels. During follow-up in 34 group 1-patients, lymphadenopathy remained stable in 28 patients, and decreased in 6 patients.
  
  
  CONCLUSIONS
  Lymphadenopathy in Robbins level II-IV and VI is common in AIT-patients and most probably related to the autoimmune process.
authors.affiliation: Department of Nuclear Medicine, University Medical Centre (UMG), Göttingen, Germany.
authors.forename: C O
authors.initials: CO
authors.lastname: Sahlmann
authors.forename: J
authors.initials: J
authors.lastname: Meller
authors.forename: H
authors.initials: H
authors.lastname: Siggelkow
authors.forename: K
authors.initials: K
authors.lastname: Homayounfar
authors.forename: M
authors.initials: M
authors.lastname: Ozerden
authors.forename: I
authors.initials: I
authors.lastname: Braune
authors.forename: G
authors.initials: G
authors.lastname: Kluge
authors.forename: B
authors.initials: B
authors.lastname: Meller
mesh_terms: D000328:Adult; D000368:Aged; D015897:Comorbidity; D005260:Female; D005858:Germany / Q000453:epidemiology; D006801:Humans; D008206:Lymphatic Diseases / Q000175:diagnosis* / Q000453:epidemiology*; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D012307:Risk Factors; D013967:Thyroiditis, Autoimmune / Q000175:diagnosis* / Q000453:epidemiology*; D014463:Ultrasonography / Q000706:statistics & numerical data*; D055815:Young Adult