title: Influenza viral RNA detection in blood as a marker to predict disease severity in hematopoietic cell transplant recipients.
abstract: Influenza RNA in blood (viremia) was detected in 9 of 79 (11.4%) hematopoietic cell transplant recipients with influenza, and was less frequently observed in patients with upper respiratory tract disease only and more frequently in patients infected with 2009 pandemic influenza A/H1N1 strain (versus seasonal strains). Viremia increased the risk of progression to lower respiratory tract disease (LRD), hypoxemia, respiratory failure, and overall and influenza-related death. Among patients with LRD, viremia was associated with increased hazards of overall and influenza-associated death (hazard ratio 3.5, 1.1-12). Thus, influenza viremia may serve as marker for overall poor outcome.
authors.affiliation: Fred Hutchinson Cancer Research Center, Seattle, Washington 98109-1024, USA.
authors.forename: Su-Mi
authors.initials: SM
authors.lastname: Choi
authors.forename: Hu
authors.initials: H
authors.lastname: Xie
authors.forename: Angela P
authors.initials: AP
authors.lastname: Campbell
authors.forename: Jane
authors.initials: J
authors.lastname: Kuypers
authors.forename: Wendy
authors.initials: W
authors.lastname: Leisenring
authors.forename: Alexandre A
authors.initials: AA
authors.lastname: Boudreault
authors.forename: Janet A
authors.initials: JA
authors.lastname: Englund
authors.forename: Lawrence
authors.initials: L
authors.lastname: Corey
authors.forename: Michael
authors.initials: M
authors.lastname: Boeckh
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D015415:Biomarkers / Q000097:blood*; D002648:Child; D002675:Child, Preschool; D005260:Female; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D007251:Influenza, Human / Q000473:pathology* / Q000821:virology; D008297:Male; D008875:Middle Aged; D009975:Orthomyxoviridae / Q000302:isolation & purification*; D012367:RNA, Viral / Q000097:blood*; D012720:Severity of Illness Index; D014180:Transplantation; D019562:Viral Load; D055815:Young Adult
chemical_list: D015415:Biomarkers; D012367:RNA, Viral