title: Dilemmas in treating hypertension in octogenarians.
abstract: One quarter of Americans will be older than 80 by 2030, and hypertension in this group will be ubiquitous. Most studies of hypertension exclude octogenarians and are not able to be generalized because of differences in physiologic and social phenomena. This review evaluates the existing literature in an effort to identify unresolved issues and guide future areas of investigation. Hypertension has been well characterized in adults and the young elderly, and the focus is on optimizing treatment regimens. However, research specifically involving this rapidly growing minority is sparse. Most studies are still trying to characterize blood pressure goals, and only one major series has begun to evaluate treatment options. Based on available evidence, it appears that an appropriate blood pressure goal may be somewhat higher in octogenarians and that thiazide diuretics may be the initial treatment of choice.
authors.affiliation: Department of Nephrology, Medstar Georgetown University Hospital, Washington, DC 20007, USA. hosstab@gmail.com
authors.forename: Hossein
authors.initials: H
authors.lastname: Tabriziani
authors.forename: Jill
authors.initials: J
authors.lastname: Steiner
authors.forename: Vasilious
authors.initials: V
authors.lastname: Papademetriou
mesh_terms: D000367:Age Factors; D000369:Aged, 80 and over; D000375:Aging; D000959:Antihypertensive Agents / Q000009:adverse effects* / Q000627:therapeutic use; D001794:Blood Pressure; D003657:Decision Making; D006801:Humans; D006973:Hypertension / Q000188:drug therapy* / Q000401:mortality / Q000473:pathology; D017410:Practice Guidelines as Topic; D018570:Risk Assessment; D014481:United States
chemical_list: D000959:Antihypertensive Agents