title: XMetA, an allosteric monoclonal antibody to the insulin receptor, improves glycaemic control in mice with diet-induced obesity.
abstract: XMetA, a high-affinity, fully human monoclonal antibody, allosterically binds to and activates the insulin receptor (INSR). Previously, we found that XMetA normalized fasting glucose and glucose tolerance in insulinopenic mice. To determine whether XMetA is also beneficial for reducing hyperglycaemia due to the insulin resistance of obesity, we have now evaluated XMetA in hyperinsulinemic mice with diet-induced obesity. XMetA treatment of these mice normalized fasting glucose for 4 weeks without contributing to weight gain. XMetA also corrected glucose tolerance and improved non-high density lipoprotein cholesterol. These studies indicate, therefore, that monoclonal antibodies that allosterically activate the INSR, such as XMetA, have the potential to be novel agents for the treatment of hyperglycaemia in conditions associated with the insulin resistance of obesity.
authors.affiliation: Preclinical Research, XOMA (US) LLC, Berkeley, CA 94710, USA. vinay@sbcglobal.net
authors.forename: V
authors.initials: V
authors.lastname: Bhaskar
authors.forename: A
authors.initials: A
authors.lastname: Lau
authors.forename: I D
authors.initials: ID
authors.lastname: Goldfine
authors.forename: A J
authors.initials: AJ
authors.lastname: Narasimha
authors.forename: L M
authors.initials: LM
authors.lastname: Gross
authors.forename: S
authors.initials: S
authors.lastname: Wong
authors.forename: B
authors.initials: B
authors.lastname: Cheung
authors.forename: M L
authors.initials: ML
authors.lastname: White
authors.forename: J A
authors.initials: JA
authors.lastname: Corbin
mesh_terms: D000818:Animals; D000911:Antibodies, Monoclonal / Q000494:pharmacology*; D001786:Blood Glucose / Q000187:drug effects*; D004032:Diet / Q000009:adverse effects; D006943:Hyperglycemia / Q000097:blood / Q000188:drug therapy* / Q000378:metabolism / Q000517:prevention & control; D007004:Hypoglycemic Agents / Q000494:pharmacology*; D007333:Insulin Resistance; D051379:Mice; D009765:Obesity / Q000097:blood / Q000188:drug therapy* / Q000209:etiology / Q000378:metabolism; D011972:Receptor, Insulin / Q000187:drug effects* / Q000378:metabolism; D015398:Signal Transduction / Q000187:drug effects
chemical_list: D000911:Antibodies, Monoclonal; D001786:Blood Glucose; D007004:Hypoglycemic Agents; D011972:Receptor, Insulin