title: Lack of association between four SNPs in the SLC22A3-LPAL2-LPA gene cluster and coronary artery disease in a Chinese Han population: a case control study.
abstract: BACKGROUND
  Lipoprotein (a) (Lp [a]) is known being correlated with coronary artery disease (CAD). The SLC22A3-LPAL2-LPA gene cluster, relating with modulating the level of plasma Lp (a), has recently been reported to be associated with CAD in Caucasians. The purpose of this study was to verify whether this finding can be expanded to the Chinese Han population.
  
  
  RESULTS
  Using a Chinese Han sample, which consisted of 1012 well-characterized CAD patients and 889 healthy controls, we tested the associations of four SNPs (rs2048327, rs3127599, rs7767084 and rs10755578) in the SLC22A3-LPAL2-LPA gene cluster, and their inferred haplotypes with the risk of CAD. Allelic, genotypic and haplotype association analyses all showed that the gene cluster was not associated with CAD in this Chinese Han sample.
  
  
  CONCLUSIONS
  We for the first time explored the association of the four SNPs in the SLC22A3-LPAL2-LPA gene cluster with CAD in a large Chinese Han sample. Nevertheless, this study did not reveal any significant evidence of this gene cluster to increase the risk of CAD in this population.
authors.affiliation: Guangdong Provincial Key Laboratory of Food, Nutrition and Health, Department of Nutrition, School of Public Health, Sun Yat-Sen University, Northern Campus, 74 Zhongshan Road 2, Guangzhou 510080, China.
authors.forename: Xiaofei
authors.initials: X
authors.lastname: Lv
authors.forename: Yuan
authors.initials: Y
authors.lastname: Zhang
authors.forename: Shaoqi
authors.initials: S
authors.lastname: Rao
authors.forename: Fengqiong
authors.initials: F
authors.lastname: Liu
authors.forename: Xiaoyu
authors.initials: X
authors.lastname: Zuo
authors.forename: Dongfang
authors.initials: D
authors.lastname: Su
authors.forename: Min
authors.initials: M
authors.lastname: Wang
authors.forename: Min
authors.initials: M
authors.lastname: Xia
authors.forename: Honghui
authors.initials: H
authors.lastname: Guo
authors.forename: Dan
authors.initials: D
authors.lastname: Feng
authors.forename: Changjiang
authors.initials: C
authors.lastname: Hong
authors.forename: Dan
authors.initials: D
authors.lastname: Li
authors.forename: Wenjun
authors.initials: W
authors.lastname: Ma
authors.forename: Ping
authors.initials: P
authors.lastname: Ouyang
authors.forename: Xinrui
authors.initials: X
authors.lastname: Li
authors.forename: Xiang
authors.initials: X
authors.lastname: Feng
authors.forename: Yan
authors.initials: Y
authors.lastname: Yang
authors.forename: Wenhua
authors.initials: W
authors.lastname: Ling
authors.forename: Jian
authors.initials: J
authors.lastname: Qiu
mesh_terms: D000368:Aged; D016633:Apolipoprotein A-II / Q000235:genetics*; D016022:Case-Control Studies; D002681:China; D003324:Coronary Artery Disease / Q000235:genetics*; D005260:Female; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006239:Haplotypes; D006801:Humans; D017270:Lipoprotein(a) / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D005810:Multigene Family; D027701:Organic Cation Transport Proteins / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D000099254:Organic Cation Transporter 3
chemical_list: D016633:Apolipoprotein A-II; D017270:Lipoprotein(a); D027701:Organic Cation Transport Proteins; D000099254:Organic Cation Transporter 3; C115794:APOA2 protein, human