title: Role of poly(ADP-ribose) polymerases in the regulation of inflammatory processes.
abstract: PARP enzymes influence the immune system at several key points and thus modulate inflammatory diseases. PARP enzymes affect immune cell maturation and differentiation and regulate the expression of inflammatory mediators such as cytokines, chemokines, inducible nitric oxide synthase and adhesion molecules. Moreover, PARP enzymes are key regulators of cell death during inflammation-related oxidative and nitrosative stress. Here we provide an overview of the different inflammatory diseases regulated by PARP enzymes.
authors.affiliation: Department of Medical Chemistry, Medical and Health Science Center, University of Debrecen, Debrecen H-4032, Hungary. baip@med.unideb.hu
authors.forename: Péter
authors.initials: P
authors.lastname: Bai
authors.forename: László
authors.initials: L
authors.lastname: Virág
mesh_terms: D000818:Animals; D015815:Cell Adhesion Molecules / Q000235:genetics / Q000378:metabolism; D016923:Cell Death; D002454:Cell Differentiation; D016207:Cytokines / Q000235:genetics / Q000276:immunology; D015870:Gene Expression; D006801:Humans; D007249:Inflammation / Q000201:enzymology* / Q000235:genetics / Q000276:immunology; D051379:Mice; D052247:Nitric Oxide Synthase Type II / Q000235:genetics / Q000378:metabolism; D018384:Oxidative Stress; D011065:Poly(ADP-ribose) Polymerases / Q000235:genetics / Q000378:metabolism*; D015398:Signal Transduction / Q000235:genetics*; D013601:T-Lymphocytes / Q000166:cytology / Q000201:enzymology; D014157:Transcription Factors / Q000235:genetics / Q000378:metabolism
chemical_list: D015815:Cell Adhesion Molecules; D016207:Cytokines; D014157:Transcription Factors; D052247:Nitric Oxide Synthase Type II; D011065:Poly(ADP-ribose) Polymerases