title: Shielding cognition from nociception with working memory.
abstract: Because pain often signals the occurrence of potential tissue damage, nociceptive stimuli have the capacity to capture attention and interfere with ongoing cognitive activities. Working memory is known to guide the orientation of attention by maintaining goal priorities active during the achievement of a task. This study investigated whether the cortical processing of nociceptive stimuli and their ability to capture attention are under the control of working memory. Event-related brain potentials (ERPs) were recorded while participants performed primary tasks on visual targets that required or did not require rehearsal in working memory (1-back vs 0-back conditions). The visual targets were shortly preceded by task-irrelevant tactile stimuli. Occasionally, in order to distract the participants, the tactile stimuli were replaced by novel nociceptive stimuli. In the 0-back conditions, task performance was disrupted by the occurrence of the nociceptive distracters, as reflected by the increased reaction times in trials with novel nociceptive distracters as compared to trials with standard tactile distracters. In the 1-back conditions, such a difference disappeared suggesting that attentional capture and task disruption induced by nociceptive distracters were suppressed by working memory, regardless of task demands. Most importantly, in the conditions involving working memory, the magnitude of nociceptive ERPs, including ERP components at early latency, were significantly reduced. This indicates that working memory is able to modulate the cortical processing of nociceptive input already at its earliest stages, and could explain why working memory reduces consequently ability of nociceptive stimuli to capture attention and disrupt performance of the primary task. It is concluded that protecting cognitive processing against pain interference is best guaranteed by keeping out of working memory pain-related information.
authors.affiliation: Department of Experimental Clinical and Health Psychology, Ghent University, Ghent, Belgium. valery.legrain@ugent.be
authors.forename: Valéry
authors.initials: V
authors.lastname: Legrain
authors.forename: Geert
authors.initials: G
authors.lastname: Crombez
authors.forename: Léon
authors.initials: L
authors.lastname: Plaghki
authors.forename: André
authors.initials: A
authors.lastname: Mouraux
mesh_terms: D000328:Adult; D003071:Cognition / Q000502:physiology*; D003118:Color Perception / Q000502:physiology; D004192:Discrimination, Psychological / Q000502:physiology; D004558:Electric Stimulation; D004569:Electroencephalography; D005071:Evoked Potentials / Q000502:physiology; D005260:Female; D006358:Hot Temperature; D006801:Humans; D008297:Male; D008570:Memory, Short-Term / Q000502:physiology*; D059225:Nociception / Q000502:physiology*; D010146:Pain / Q000503:physiopathology* / Q000523:psychology; D010775:Photic Stimulation; D011597:Psychomotor Performance / Q000502:physiology; D011930:Reaction Time / Q000502:physiology; D055815:Young Adult