title: Four new compounds from the basidiomycete Craterellus odoratus.
abstract: Four new compounds, craterellin D (1), 5-hydroxymethyl-2-hydroxy-4-methoxy-phenylethanone (2), 5-carboxyl-2-[2-(1,2-dihydroxyisopropyl)]-benzofuran (3), and 6α-hydroxy-3-methoxy-4α-methyl-2-cyclohexen-1-one (4), were isolated from cultures of the basidiomycete Craterellus odoratus, together with three known compounds craterellins A-C (5-7). Structures of 1-4 were elucidated on the basis of extensive spectroscopic analysis. Selected compounds were evaluated for their inhibitory activities against one isozyme of 11β-hydroxysteroid dehydrogenase (11β-HSD1) and cytotoxic activities on five tumor cell lines. Compound 2 was found to exhibit inhibitory activity against human 11β-HSD1 with an IC₅₀ value of 16.4 μg/ml.
authors.affiliation: State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China.
authors.forename: Hua
authors.initials: H
authors.lastname: Guo
authors.forename: Tao
authors.initials: T
authors.lastname: Feng
authors.forename: Zheng-Hui
authors.initials: ZH
authors.lastname: Li
authors.forename: Ji-Kai
authors.initials: JK
authors.lastname: Liu
mesh_terms: D043205:11-beta-Hydroxysteroid Dehydrogenase Type 1 / Q000037:antagonists & inhibitors; D042842:11-beta-Hydroxysteroid Dehydrogenases / Q000037:antagonists & inhibitors* / Q000378:metabolism; D001487:Basidiomycota / Q000737:chemistry; D003512:Cyclohexanones; D006801:Humans; D020128:Inhibitory Concentration 50; D007527:Isoenzymes; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D012717:Sesquiterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology
chemical_list: D003512:Cyclohexanones; D007527:Isoenzymes; D012717:Sesquiterpenes; C551019:craterellin A; C577524:craterellin D; C028215:2-cyclohexen-1-one; D043205:11-beta-Hydroxysteroid Dehydrogenase Type 1; D042842:11-beta-Hydroxysteroid Dehydrogenases