title: 1,8-Naphthyridine-2,7-diamine: a potential universal reader of Watson-Crick base pairs for DNA sequencing by electron tunneling.
abstract: With the aid of Density Functional Theory (DFT), we designed 1,8-naphthyridine-2,7-diamine as a recognition molecule to read DNA base pairs for genomic sequencing by electron tunneling. NMR studies show that it can form stable triplets with both A : T and G : C base pairs through hydrogen bonding. Our results suggest that the naphthyridine molecule should be able to function as a universal base pair reader in a tunneling gap, generating distinguishable signatures under electrical bias for each of DNA base pairs.
authors.affiliation: Center for Single Molecule Biophysics, The Biodesign Institute, Arizona State University, Tempe, Arizona 85287, USA.
authors.forename: Feng
authors.initials: F
authors.lastname: Liang
authors.forename: Stuart
authors.initials: S
authors.lastname: Lindsay
authors.forename: Peiming
authors.initials: P
authors.lastname: Zhang
mesh_terms: D020029:Base Pairing; D004247:DNA / Q000737:chemistry* / Q000235:genetics; D003959:Diamines / Q000138:chemical synthesis / Q000737:chemistry*; D006860:Hydrogen Bonding; D009287:Naphthyridines / Q000138:chemical synthesis / Q000737:chemistry*; D019906:Nuclear Magnetic Resonance, Biomolecular; D011789:Quantum Theory; D017422:Sequence Analysis, DNA
chemical_list: C579479:1,8-naphthyridine-2,7-diamine; D003959:Diamines; D009287:Naphthyridines; D004247:DNA