title: Efficacy of moxibustion for pre- or stage I hypertension: study protocol for a pilot randomized controlled trial.
abstract: BACKGROUND
  Hypertension is a risk factor for cardiovascular disease, and the prevalence of hypertension tends to increase with age. Current treatments for hypertension have adverse side effects and poor adherence. The purpose of this study is to evaluate the effects of moxibustion on blood pressure in individuals with pre- or stage I hypertension.
  
  
  METHODS
  Forty-five subjects with pre- or stage I hypertension will be randomized into three groups: treatment group A (2 times/week), treatment group B (3 times/week), and the control group (non-treated group). The inclusion criteria will be as follows: (1) aged between 19 and 65 years; (2) prehypertension or stage I hypertension (JNC 7, Seventh Report of the Joint National Committee on the Prevention, Detection, Evaluation, and Treatment of High Blood Pressure); (3) the participants are volunteers and written consent obtained.The participants in the treatment group A will undergo indirect moxibustion 2 times per week for 4 weeks, and the participants in the treatment group B will undergo indirect moxibustion 3 times per week for 4 weeks. The participants in the control group (non-treated group) will maintain their current lifestyle, including diet and exercise. The use of antihypertensive medication is not permitted. The primary endpoint will be a change in patient blood pressure. The secondary endpoints will be the body mass index, lipid profile, EuroQol and Heart Rate Variability. The data will be analyzed with the Student's t-test and analysis of variance (ANOVA) (p < 0.05).
  
  
  CONCLUSIONS
  The results of this study will help to establish the optimal approach for the care of adults with pre- or stage I hypertension.
  
  
  BACKGROUND
  Clinical Research Information Service KCT0000469.
authors.affiliation: Medical Research Division, Korea Institute of Oriental Medicine, Daejeon, South Korea.
authors.forename: Kyung-Min
authors.initials: KM
authors.lastname: Shin
authors.forename: Ji-Eun
authors.initials: JE
authors.lastname: Park
authors.forename: Yan
authors.initials: Y
authors.lastname: Liu
authors.forename: Hee-Jung
authors.initials: HJ
authors.lastname: Jung
authors.forename: So-Young
authors.initials: SY
authors.lastname: Jung
authors.forename: Min-Hee
authors.initials: MH
authors.lastname: Lee
authors.forename: Kyung-Won
authors.initials: KW
authors.lastname: Kang
authors.forename: Tae-Han
authors.initials: TH
authors.lastname: Yook
authors.forename: Sun-Mi
authors.initials: SM
authors.lastname: Choi
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D006973:Hypertension / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D009071:Moxibustion / Q000379:methods*; D010865:Pilot Projects; D058246:Prehypertension / Q000628:therapy*; D056910:Republic of Korea; D012107:Research Design; D011795:Surveys and Questionnaires