title: Synthesis of substituted thiophenes by palladium-catalyzed heterocyclodehydration of 1-mercapto-3-yn-2-ols in conventional and nonconventional solvents.
abstract: A variety of readily available 1-mercapto-3-yn-2-ols 5 were conveniently converted into the corresponding thiophenes 6 in good to high yields in MeOH as the solvent at 50-100 °C in the presence of catalytic amounts (1-2%) of PdI(2) in conjunction with KI (KI:PdI(2) molar ratio = 10). The catalyst could be made recyclable employing an ionic liquid, such as BmimBF(4), as the solvent under suitable conditions.
authors.affiliation: Dipartimento di Scienze Farmaceutiche, Università della Calabria, 87036 Arcavacata di Rende (CS), Italy. b.gabriele@unical.it
authors.forename: Bartolo
authors.initials: B
authors.lastname: Gabriele
authors.forename: Raffaella
authors.initials: R
authors.lastname: Mancuso
authors.forename: Lucia
authors.initials: L
authors.lastname: Veltri
authors.forename: Vito
authors.initials: V
authors.lastname: Maltese
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Salerno
mesh_terms: D002384:Catalysis; D003500:Cyclization; D006571:Heterocyclic Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D052578:Ionic Liquids; D015394:Molecular Structure; D010165:Palladium / Q000737:chemistry*; D012997:Solvents / Q000737:chemistry*; D013876:Thiophenes / Q000138:chemical synthesis* / Q000737:chemistry*
chemical_list: D006571:Heterocyclic Compounds; D052578:Ionic Liquids; D012997:Solvents; D013876:Thiophenes; D010165:Palladium