title: IL-23 gene expression in PBMCs of patients with coronary artery disease.
abstract: OBJECTIVE
  Both adaptive and innate immune systems are involved in coronary artery disease (CAD). The aim of this study was to evaluate TH17 cytokines expression profiles in un-stimulated peripheral blood lymphocytes (PBMCs) of patients with coronary artery disease.
  
  
  METHODS
  Expression profiles of IL-17, IL-23, and TGF-β1 were determined in individuals with and without CAD using Real-time PCR.
  
  
  RESULTS
  A significant decrease in IL-23 gene expression in un-stimulated PBMCs of patients with CAD compared to those without CAD was found (p=0.003, OR=0.045, 95% CI: 0.006-0.355).
  
  
  CONCLUSIONS
  Our data reinforce the potential role of the IL-23 as a critical regulatory molecule that bridges the innate and adaptive arms of the immune system in the complex mechanisms associated with the development of atherosclerosis.
authors.affiliation: Endocrinology and Metabolism Research Center, Tehran University of Medical Sciences, Iran.
authors.forename: Maryam
authors.initials: M
authors.lastname: Khojasteh-Fard
authors.forename: Milad
authors.initials: M
authors.lastname: Abolhalaj
authors.forename: Parvin
authors.initials: P
authors.lastname: Amiri
authors.forename: Majid
authors.initials: M
authors.lastname: Zaki
authors.forename: Zahra
authors.initials: Z
authors.lastname: Taheri
authors.forename: Mostafa
authors.initials: M
authors.lastname: Qorbani
authors.forename: Javad Tavakkoly
authors.initials: JT
authors.lastname: Bazzaz
authors.forename: Mahsa M
authors.initials: MM
authors.lastname: Amoli
mesh_terms: D000368:Aged; D003324:Coronary Artery Disease / Q000235:genetics / Q000276:immunology* / Q000378:metabolism; D015536:Down-Regulation; D005260:Female; D006801:Humans; D020381:Interleukin-17 / Q000235:genetics / Q000378:metabolism; D053759:Interleukin-23 / Q000235:genetics* / Q000378:metabolism; D008214:Lymphocytes / Q000276:immunology* / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D014158:Transcription, Genetic; D053773:Transforming Growth Factor beta1 / Q000235:genetics / Q000378:metabolism
chemical_list: D020381:Interleukin-17; D053759:Interleukin-23; D053773:Transforming Growth Factor beta1