title: Efficacy of temozolomide in a central nervous system relapse of neuroblastoma with O 6 -methylguanine methyltransferase (MGMT) promoter methylation.
abstract: We describe a case of a 5-year-old girl with central nervous system relapse of neuroblastoma after high-dose chemotherapy and autologous stem cell transplantation. Although the brain metastasis was surgically removed, she had a second relapse in the same region with leptomeningeal dissemination despite receiving irinotecan. Administration of temozolomide in addition to irinotecan led to her third complete response and the patient has been in complete response for >24 months. The tumor had no expression of the O  -methylguanine methyltransferase (MGMT) gene due to promoter methylation. Temozolomide is an attractive candidate treatment in neuroblastoma with methylated MGMT, especially in central nervous system relapsed cases.
authors.affiliation: Division of Pediatrics, Department of Reproductive and Developmental Medicine, University of Miyazaki, Miyazaki, Japan.
authors.forename: Ai
authors.initials: A
authors.lastname: Yamada
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Moritake
authors.forename: Hidemi
authors.initials: H
authors.lastname: Shimonodan
authors.forename: Kiyotaka
authors.initials: K
authors.lastname: Yokogami
authors.forename: Hideo
authors.initials: H
authors.lastname: Takeshima
authors.forename: Kousuke
authors.initials: K
authors.lastname: Marutsuka
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Nunoi
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D001932:Brain Neoplasms / Q000556:secondary / Q000628:therapy*; D002166:Camptothecin / Q000008:administration & dosage / Q000031:analogs & derivatives; D002675:Child, Preschool; D003131:Combined Modality Therapy; D019175:DNA Methylation; D015254:DNA Modification Methylases / Q000235:genetics*; D045643:DNA Repair Enzymes / Q000235:genetics*; D003606:Dacarbazine / Q000008:administration & dosage / Q000031:analogs & derivatives; D005260:Female; D006801:Humans; D000077146:Irinotecan; D009364:Neoplasm Recurrence, Local / Q000473:pathology / Q000628:therapy*; D009447:Neuroblastoma / Q000473:pathology / Q000628:therapy*; D011379:Prognosis; D011401:Promoter Regions, Genetic / Q000235:genetics*; D033581:Stem Cell Transplantation; D000077204:Temozolomide; D014182:Transplantation, Autologous; D025521:Tumor Suppressor Proteins / Q000235:genetics*
chemical_list: D025521:Tumor Suppressor Proteins; D000077146:Irinotecan; D003606:Dacarbazine; D015254:DNA Modification Methylases; C515491:MGMT protein, human; D045643:DNA Repair Enzymes; D002166:Camptothecin; D000077204:Temozolomide