title: [Stress effect on the development of hemorrhagic stroke].
abstract: The objective of this work was to study how stress, activity in the open field test, and conformational properties of albumin-binding sites are associated with experimental hemorrhagic stroke in rats. The open-field behavioral pattern in rats was characterized by the previously developed by us activity index. In accordance with this activity index, rats were divided into two groups, i.e., active and passive animals. The animals were subjected to experimental hemorrhagic stroke with or without previous emotional stress. It was shown that the previous stress affected the stroke development. Stress loading before experimental stroke changed albumin conformational properties in rats with active and passive behavioral patterns in different ways. It was associated with different ability of the albumin globule to undergo pH-induced transition N-F and in different accessibility of albumin-bound fluorescent probe CAPIDAN to nitrate-induced fluorescence quenching.
authors.forename: V V
authors.initials: VV
authors.lastname: Kalinina
authors.forename: N O
authors.initials: NO
authors.lastname: Ivannikova
authors.forename: E V
authors.initials: EV
authors.lastname: Koplik
authors.forename: N V
authors.initials: NV
authors.lastname: Smolina
authors.forename: Iu A
authors.initials: IuA
authors.lastname: Gryzunov
authors.forename: G E
authors.initials: GE
authors.lastname: Dobretsov
mesh_terms: D000223:Adaptation, Psychological / Q000502:physiology; D000818:Animals; D001522:Behavior, Animal; D001665:Binding Sites; D005106:Exploratory Behavior / Q000502:physiology; D005456:Fluorescent Dyes; D007094:Imides; D020300:Intracranial Hemorrhages / Q000209:etiology* / Q000503:physiopathology; D008297:Male; D009281:Naphthalenes; D051381:Rats; D017208:Rats, Wistar; D012149:Restraint, Physical; D012709:Serum Albumin / Q000737:chemistry*; D013315:Stress, Psychological / Q000150:complications* / Q000503:physiopathology; D020521:Stroke / Q000209:etiology* / Q000503:physiopathology
chemical_list: D005456:Fluorescent Dyes; D007094:Imides; D009281:Naphthalenes; D012709:Serum Albumin; C511435:dimethylaminonaphthalic acid N-carboxyphenylimide