title: Cortico-cardio-respiratory network interactions during anesthesia.
abstract: General anesthetics are used during medical and surgical procedures to reversibly induce a state of total unconsciousness in patients. Here, we investigate, from a dynamic network perspective, how the cortical and cardiovascular systems behave during anesthesia by applying nonparametric spectral techniques to cortical electroencephalography, electrocardiogram and respiratory signals recorded from anesthetized rats under two drugs, ketamine-xylazine (KX) and pentobarbital (PB). We find that the patterns of low-frequency cortico-cardio-respiratory network interactions may undergo significant changes in network activity strengths and in number of network links at different depths of anesthesia dependent upon anesthetics used.
authors.affiliation: School of Computer and Communication Sciences, École Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland.
authors.forename: Yuri
authors.initials: Y
authors.lastname: Shiogai
authors.forename: Mukesh
authors.initials: M
authors.lastname: Dhamala
authors.forename: Kumiko
authors.initials: K
authors.lastname: Oshima
authors.forename: Martin
authors.initials: M
authors.lastname: Hasler
mesh_terms: D000768:Anesthesia, General; D018681:Anesthetics, General / Q000627:therapeutic use*; D000818:Animals; D002319:Cardiovascular System / Q000187:drug effects* / Q000378:metabolism*; D004562:Electrocardiography; D004569:Electroencephalography; D007649:Ketamine / Q000627:therapeutic use; D008297:Male; D008962:Models, Theoretical; D010424:Pentobarbital / Q000627:therapeutic use; D051381:Rats; D017208:Rats, Wistar; D014991:Xylazine / Q000627:therapeutic use
chemical_list: D018681:Anesthetics, General; D014991:Xylazine; D007649:Ketamine; D010424:Pentobarbital