title: The trifluoromethyl transformation synthesis, crystal structure and insecticidal activities of novel 2-pyrrolecarboxamide and 2-pyrrolecarboxlate.
abstract: Two series of 2-phenylpyrroles: 3-bromo-5-(4-chlorophenyl)-4-cyanopyrrole-2-carboxamide (5a-5d) and 3-bromo-5-(4-chlorophenyl)-4-cyanopyrrole-2-carboxylate (6a-6c) were synthesized by a novel trifluoromethyl transformation. The result of insecticidal bioassays indicated that 6a-6c had moderate larvicidal activity against oriental armyworm and 6b also had good acaricidal activity, so 3-bromo-5-(4-chlorophenyl)-4-cyanopyrrole-2-carboxylate derivatives were expected to become lead compounds for new pesticides.
authors.affiliation: State Key Laboratory of Elemento-Organic Chemistry, Institute of Elemento-Organic Chemistry, Nankai University, Tianjin 300071, People's Republic of China.
authors.forename: Yongqiang
authors.initials: Y
authors.lastname: Li
authors.forename: Pengxiang
authors.initials: P
authors.lastname: Zhang
authors.forename: Qiaoqiao
authors.initials: Q
authors.lastname: Ma
authors.forename: Haibin
authors.initials: H
authors.lastname: Song
authors.forename: Yuxiu
authors.initials: Y
authors.lastname: Liu
authors.forename: Qingmin
authors.initials: Q
authors.lastname: Wang
mesh_terms: D000577:Amides / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D000818:Animals; D002264:Carboxylic Acids / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D018360:Crystallography, X-Ray; D005461:Fluorine / Q000737:chemistry*; D007306:Insecticides / Q000138:chemical synthesis* / Q000737:chemistry; D007814:Larva / Q000187:drug effects; D008968:Molecular Conformation; D009036:Moths / Q000187:drug effects / Q000254:growth & development; D011758:Pyrroles / Q000737:chemistry*; D013112:Spiders / Q000187:drug effects
chemical_list: D000577:Amides; D002264:Carboxylic Acids; D007306:Insecticides; D011758:Pyrroles; D005461:Fluorine