title: Pleiotropic effects of sitagliptin in the treatment of type 2 diabetes mellitus patients.
abstract: BACKGROUND
  Sitagliptin is a DPP-4 inhibitor that became available for use in Japan three years ago. This study was conducted to identify the pleiotropic effects of sitagliptin other than blood glucose lowering in Japanese type 2 diabetes mellitus patients.
  
  
  METHODS
  A retrospective, observational study of 940 type 2 diabetes mellitus patients was conducted. The primary outcome measures were HbA1c, blood pressure, and lipid profiles measured at 0, 4, and 12 weeks of sitagliptin therapy.
  
  
  RESULTS
  After 12 weeks of sitagliptin treatment, compared with baseline, HbA1c decreased 0.64% ± 0.86%; systolic blood pressure (SBP) and diastolic blood pressure (DBP) decreased significantly; and serum creatinine (Cr) and uric acid (UA) levels were mildly but significantly elevated. A correlation analysis of the changes in systolic blood pressure, diastolic blood pressure, creatinine, and uric acid (ΔSBP, ΔDBP, ΔCr, ΔUA) from baseline to 12 weeks showed significant negative correlations between ΔSBP and ΔCr, ΔSBP and ΔUA, and ΔDBP and ΔCr. Total cholesterol and postprandial triglycerides were significantly decreased at both 4 and 12 weeks. Alkaline phosphatase (ALP) decreased significantly, and there was a significant positive correlation between changes in ALP and HbA1c.
  
  
  CONCLUSIONS
  Sitagliptin seems to be effective not only in lowering blood glucose but also in lowering blood pressure, lipid, and ALP levels. Sitagliptin appears to contribute to a Na-diuretic action due to GLP-1.
authors.affiliation: The Study Group of the Diabetes Committee, Kanagawa Physicians Association, 3F Kanagawa-ken Sogo Iryo Kaikan, 3-1 Fujimi-cho, Naka-ward, Yokohama-city, Kanagawa 231-0037, Japan.
authors.forename: Akira
authors.initials: A
authors.lastname: Kubota
authors.forename: Hajime
authors.initials: H
authors.lastname: Maeda
authors.forename: Akira
authors.initials: A
authors.lastname: Kanamori
authors.forename: Kiyokazu
authors.initials: K
authors.lastname: Matoba
authors.forename: Yasuyuki
authors.initials: Y
authors.lastname: Jin
authors.forename: Fuyuki
authors.initials: F
authors.lastname: Minagawa
authors.forename: Mitsuo
authors.initials: M
authors.lastname: Obana
authors.forename: Koutarou
authors.initials: K
authors.lastname: Iemitsu
authors.forename: Shogo
authors.initials: S
authors.lastname: Ito
authors.forename: Hikaru
authors.initials: H
authors.lastname: Amemiya
authors.forename: Mizuki
authors.initials: M
authors.lastname: Kaneshiro
authors.forename: Masahiko
authors.initials: M
authors.lastname: Takai
authors.forename: Hideaki
authors.initials: H
authors.lastname: Kaneshige
authors.forename: Kazuhiko
authors.initials: K
authors.lastname: Hoshino
authors.forename: Masashi
authors.initials: M
authors.lastname: Ishikawa
authors.forename: Nobuaki
authors.initials: N
authors.lastname: Minami
authors.forename: Tetsuo
authors.initials: T
authors.lastname: Takuma
authors.forename: Nobuo
authors.initials: N
authors.lastname: Sasai
authors.forename: Sachio
authors.initials: S
authors.lastname: Aoyagi
authors.forename: Takehiro
authors.initials: T
authors.lastname: Kawata
authors.forename: Atsuko
authors.initials: A
authors.lastname: Mokubo
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Takeda
authors.forename: Shin
authors.initials: S
authors.lastname: Honda
authors.forename: Hideo
authors.initials: H
authors.lastname: Machimura
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Motomiya
authors.forename: Manabu
authors.initials: M
authors.lastname: Waseda
authors.forename: Yoshikazu
authors.initials: Y
authors.lastname: Naka
authors.forename: Yasushi
authors.initials: Y
authors.lastname: Tanaka
authors.forename: Yasuo
authors.initials: Y
authors.lastname: Terauchi
authors.forename: Ikuro
authors.initials: I
authors.lastname: Matsuba