title: Pharmacotherapy for pulmonary hypertension.
abstract: Pulmonary arterial hypertension is a serious disease with significant morbidity and mortality. Although it can occur idiopathically, it is more commonly associated with other cardiac or lung diseases. While most of the available therapies have been tested in adult populations and most therapies in children remain off-label, new reports and randomized trials are emerging that inform the treatment of pediatric populations. This review discusses currently available therapies for pediatric pulmonary hypertension, their biological rationales, and evidence for their clinical effectiveness.
authors.affiliation: Department of Pediatrics, The Ann and Robert H. Lurie Children's Hospital of Chicago, Northwestern University, 225 East Chicago Avenue, Chicago, IL 60611, USA. r-steinhorn@northwestern.edu
authors.forename: Robin H
authors.initials: RH
authors.lastname: Steinhorn
mesh_terms: D000959:Antihypertensive Agents / Q000627:therapeutic use*; D002648:Child; D006801:Humans; D006976:Hypertension, Pulmonary / Q000188:drug therapy*; D007231:Infant, Newborn; D010547:Persistent Fetal Circulation Syndrome / Q000188:drug therapy*
chemical_list: D000959:Antihypertensive Agents