title: Enabling Wittig reaction on site-specific protein modification.
abstract: An efficient aqueous Wittig reaction was enabled on protein bioconjugation for the first time. By investigating the reaction on small molecules, peptides, and proteins, a site-specific reaction targeting "aldehyde tag" was presented. A variety of functional groups could be introduced into the protein of interest.
authors.affiliation: State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Xue Yuan Road No. 38, Beijing 100191, China.
authors.forename: Ming-Jie
authors.initials: MJ
authors.lastname: Han
authors.forename: De-Cai
authors.initials: DC
authors.lastname: Xiong
authors.forename: Xin-Shan
authors.initials: XS
authors.lastname: Ye
mesh_terms: D000447:Aldehydes / Q000737:chemistry; D016209:Interleukin-8 / Q000737:chemistry / Q000378:metabolism; D010455:Peptides / Q000737:chemistry / Q000378:metabolism; D010504:Periodic Acid / Q000737:chemistry; D011506:Proteins / Q000737:chemistry* / Q000378:metabolism; D019032:Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization
chemical_list: D000447:Aldehydes; D016209:Interleukin-8; D010455:Peptides; D011506:Proteins; D010504:Periodic Acid; C009288:metaperiodate