title: Compounding errors in 2 dogs receiving anticonvulsants.
abstract: Two cases that involve drug compounding errors are described. One dog exhibited increased seizure activity due to a compounded, flavored phenobarbital solution that deteriorated before the expiration date provided by the compounder. The other dog developed clinical signs of hyperkalemia and bromine toxicity following a 5-fold compounding error in the concentration of potassium bromide (KBr).
authors.affiliation: Biomedical Sciences, Atlantic Veterinary College, University of Prince Edward Island, 550 University Avenue, Charlottetown, Prince Edward Island CIA 4P3, Canada. smcconkey@upei.ca
authors.forename: Sandra E
authors.initials: SE
authors.lastname: McConkey
authors.forename: Susan
authors.initials: S
authors.lastname: Walker
authors.forename: Cathy
authors.initials: C
authors.lastname: Adams
mesh_terms: D000818:Animals; D000927:Anticonvulsants / Q000009:adverse effects* / Q000627:therapeutic use; D001965:Bromides / Q000097:blood / Q000627:therapeutic use; D004283:Dog Diseases / Q000097:blood / Q000139:chemically induced* / Q000188:drug therapy; D004285:Dogs; D004339:Drug Compounding / Q000009:adverse effects / Q000662:veterinary*; D008297:Male; D008508:Medication Errors / Q000662:veterinary*; D010634:Phenobarbital / Q000009:adverse effects / Q000627:therapeutic use; D017680:Potassium Compounds / Q000097:blood / Q000627:therapeutic use; D012640:Seizures / Q000188:drug therapy / Q000662:veterinary*
chemical_list: D000927:Anticonvulsants; D001965:Bromides; D017680:Potassium Compounds; C039004:potassium bromide; D010634:Phenobarbital