title: Association of Alzheimer's Disease With APOE and IL-1α Gene Polymorphisms.
abstract: Apolipoprotein E (ApoE) gene polymorphisms are thought to be the most important genetic risk factor in the pathogenesis of late onset and sporadic Alzheimer's disease (AD). Moreover, interleukin-1α (IL-1α) is found to be associated with the pathogenesis of AD. In this research, ∊2, ∊3, and ∊4 polymorphisms of ApoE gene and C889T polymorphism of IL-1α gene were genotyped in patients with AD and controls. Genotyping was performed by real-time polymerase chain reaction. ∊3/∊3 and ∊3/∊4 genotype frequencies were significantly higher in control and case groups, respectively. While ∊3 allele frequencies were significantly higher in the control group, ∊2 and ∊4 allele frequencies were significantly higher among the cases with AD. No difference was found between the groups according to C889T polymorphism of IL-1α. In conclusion, we demonstrated that there was a strong association between ApoE ∊4 allele and AD, while there was no relation with IL-1α C889T polymorphisms for this study.
authors.affiliation: Department of Medical Genetics, Afyon Kocatepe University, Afyonkarahisar, Turkey handanstarr@gmail.com.
authors.forename: Saliha Handan
authors.initials: SH
authors.lastname: Yildiz
authors.affiliation: Department of Medical Genetics, Afyon Kocatepe University, Afyonkarahisar, Turkey.
authors.forename: Mujgan Ozdemir
authors.initials: MO
authors.lastname: Erdogan
authors.affiliation: Department of Medical Genetics, Eskisehir Osmangazi University, Eskisehir, Turkey.
authors.forename: Sevilhan
authors.initials: S
authors.lastname: Artan
authors.affiliation: Department of Medical Genetics, Afyon Kocatepe University, Afyonkarahisar, Turkey.
authors.forename: Mustafa
authors.initials: M
authors.lastname: Solak
authors.affiliation: Department of Neurology, Afyon Kocatepe University, Afyonkarahisar, Turkey.
authors.forename: Mehmet
authors.initials: M
authors.lastname: Yaman
authors.affiliation: Department of Neurology, Eskisehir Osmangazi University, Eskisehir, Turkey.
authors.forename: Belgin Demet
authors.initials: BD
authors.lastname: Ozbabalik
authors.affiliation: Department of Medical Genetics, Afyon Kocatepe University, Afyonkarahisar, Turkey.
authors.forename: Evrim Suna Arikan
authors.initials: ES
authors.lastname: Terzi
mesh_terms: D000368:Aged; D000544:Alzheimer Disease / Q000235:genetics*; D053329:Apolipoprotein E2 / Q000235:genetics; D053318:Apolipoprotein E3 / Q000235:genetics; D053327:Apolipoprotein E4 / Q000235:genetics*; D006801:Humans; D053582:Interleukin-1alpha / Q000235:genetics*; D011110:Polymorphism, Genetic; D014421:Turkey
chemical_list: D053329:Apolipoprotein E2; D053318:Apolipoprotein E3; D053327:Apolipoprotein E4; C508584:IL1A protein, human; D053582:Interleukin-1alpha