title: Effects of respiratory mechanics on the capnogram phases: importance of dynamic compliance of the respiratory system.
abstract: BACKGROUND
  The slope of phase III of the capnogram (SIII) relates to progressive emptying of the alveoli, a ventilation/perfusion mismatch, and ventilation inhomogeneity. S(III) depends not only on the airway geometry, but also on the dynamic respiratory compliance (Crs); this latter effect has not been evaluated. Accordingly, we established the value of SIII for monitoring airway resistance during mechanical ventilation.
  
  
  METHODS
  Sidestream capnography was performed during mechanical ventilation in patients undergoing elective cardiac surgery (n = 144). The airway resistance (Raw), total respiratory resistance and Crs displayed by the ventilator, the partial pressure of arterial oxygen (PaO2) and S(III) were measured in time domain (S(T-III)) and in a smaller cohort (n = 68) by volumetry (S(V-III)) with and without normalization to the average CO2 phase III concentration. Measurements were performed at positive end-expiratory pressure (PEEP) levels of 3, 6 and 9 cmH2O in patients with healthy lungs (Group HL), and in patients with respiratory symptoms involving low (Group LC), medium (Group MC) or high Crs (Group HC).
  
  
  RESULTS
  S(T-III) and S(V-III) exhibited similar PEEP dependencies and distribution between the protocol groups formed on the basis of Crs. A wide interindividual scatter was observed in the overall Raw-S(T-III) relationship, which was primarily affected by Crs. Decreases in Raw with increasing PEEP were reflected in sharp falls in S(III) in Group HC, and in moderate decreases in S(III) in Group MC, whereas S(T-III) was insensitive to changes in airway caliber in Groups LC and HL.
  
  
  CONCLUSIONS
  SIII assessed in the time domain and by volumetry provide meaningful information about alterations in airway caliber, but only within an individual patient. Although S(T-III) may be of value for bedside monitoring of the airway properties, its sensitivity depends on Crs. Thus, assessment of the capnogram shape should always be coupled with Crs when the airway resistance or oxygenation are evaluated.
authors.forename: Barna
authors.initials: B
authors.lastname: Babik
authors.forename: Zsófia
authors.initials: Z
authors.lastname: Csorba
authors.forename: Dorottya
authors.initials: D
authors.lastname: Czövek
authors.forename: Patrick N
authors.initials: PN
authors.lastname: Mayr
authors.forename: Gábor
authors.initials: G
authors.lastname: Bogáts
authors.forename: Ferenc
authors.initials: F
authors.lastname: Peták
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000403:Airway Resistance / Q000502:physiology*; D019296:Capnography / Q000379:methods / Q000639:trends*; D005260:Female; D006801:Humans; D008170:Lung Compliance / Q000502:physiology*; D008297:Male; D008875:Middle Aged; D012121:Respiration, Artificial / Q000379:methods / Q000639:trends*; D015656:Respiratory Mechanics / Q000502:physiology*