title: Reduced fractional anisotropy of corpus callosum modulates inter-hemispheric resting state functional connectivity in migraine patients without aura.
abstract: BACKGROUND
  Diffusion tensor imaging (DTI) study revealed reduced fractional anisotropy (FA) values in the corpus callosum (CC) in migraine patients without aura. Abnormalities in white matter integrity, particularly in the CC, may affect inter-hemispheric resting state functional connectivity (RSFC). Unfortunately, relatively little is known about the alterations in functional interactions between the cerebral hemispheres during resting state in migraine patients without aura, and even less about how the inter-hemispheric RSFC are affected by the abnormalities of the CC.
  
  
  RESULTS
  Twenty-one migraine patients without aura and 21 healthy controls participated in this study, age-, sex-, and education-matched. Tract-based spatial statistics (TBSS) was employed to investigate the white matter alterations of the CC. Meanwhile, voxel-mirrored homotopic connectivity (VMHC) was used to compare the inter-hemispheric RSFC differences between the patients and controls. TBSS analysis revealed reduced FA values in the genu and the splenium of CC in patient group. VMHC analysis showed decreased inter-hemispheric RSFC of anterior cingulate cortex (ACC) in migraine patients without aura relative to that of the controls. Furthermore, in migraine patients without aura, the reduced FA values of the genu of CC correlated with the decreased inter-hemispheric RSFC of the ACC.
  
  
  CONCLUSIONS
  Our findings demonstrated that the migraine patients without aura showed reduced FA values of the genu of CC and decreased inter-hemispheric RSFC of the ACC. The correlation between the above structural and functional changes suggested that the reduced fractional anisotropy (FA) of CC modulates inter-hemispheric VMHC in migraine patients without aura. Our results demonstrated that the VMHC alterations of ACC can reflect the FA changes of the genu of CC in migraine patients without aura.
authors.affiliation: Life Sciences Research Center, School of Life Sciences and Technology, Xidian University, Xi'an, Shaanxi, China.
authors.forename: Kai
authors.initials: K
authors.lastname: Yuan
authors.forename: Wei
authors.initials: W
authors.lastname: Qin
authors.forename: Peng
authors.initials: P
authors.lastname: Liu
authors.forename: Ling
authors.initials: L
authors.lastname: Zhao
authors.forename: Dahua
authors.initials: D
authors.lastname: Yu
authors.forename: Limei
authors.initials: L
authors.lastname: Zhao
authors.forename: Minghao
authors.initials: M
authors.lastname: Dong
authors.forename: Jixin
authors.initials: J
authors.lastname: Liu
authors.forename: Xuejuan
authors.initials: X
authors.lastname: Yang
authors.forename: Karen M
authors.initials: KM
authors.lastname: von Deneen
authors.forename: Fanrong
authors.initials: F
authors.lastname: Liang
authors.forename: Jie
authors.initials: J
authors.lastname: Tian
mesh_terms: D000328:Adult; D016880:Anisotropy; D054022:Cerebrum / Q000473:pathology* / Q000503:physiopathology*; D003337:Corpus Callosum / Q000473:pathology* / Q000503:physiopathology*; D056324:Diffusion Tensor Imaging; D004827:Epilepsy; D005260:Female; D006801:Humans; D008297:Male; D008881:Migraine Disorders / Q000175:diagnosis* / Q000503:physiopathology*; D055815:Young Adult