title: Carcinoma cuniculatum: not a verrucous carcinoma.
abstract: BACKGROUND
  Carcinoma cuniculatum and verrucous carcinoma are both very well differentiated forms of squamous carcinoma and thus difficult to separate histologically from pseudocarcinomatous hyperplasia. The diagnosis of each often requires clinical-pathologic correlation.
  
  
  METHODS
  We reviewed the literature on cases reported as carcinoma cuniculatum and compared these to the cases originally reported by Aird et al. In addition, we report an additional case of this entity that we encountered in our practice.
  
  
  RESULTS
  In reviewing the literature it is evident that most authors consider carcinoma cuniculatum and verrucous carcinoma to be synonymous even though Aird's original two cases had no verrucous features. The lack of a clear conceptual distinction between these two entities may cause diagnostic confusion.
  
  
  CONCLUSIONS
  The purpose of this report is to record a case of carcinoma cuniculatum which the authors believe to be similar to those reported by Aird et al., to emphasize the differences between carcinoma cuniculatum and verrucous carcinoma, and to explain how the lack of a clear conceptual distinction between these two tumors can lead to further delay in an already difficult diagnosis.
authors.affiliation: Department of Pathology and Laboratory Medicine, University of Florida College of Medicine-Jacksonville, Jacksonville, FL, USA. melanie.kubik@jax.ufl.edu
authors.forename: M J
authors.initials: MJ
authors.lastname: Kubik
authors.forename: R M
authors.initials: RM
authors.lastname: Rhatigan
mesh_terms: D001706:Biopsy; D002294:Carcinoma, Squamous Cell / Q000145:classification / Q000175:diagnosis* / Q000601:surgery; D018289:Carcinoma, Verrucous / Q000145:classification / Q000175:diagnosis* / Q000601:surgery; D003937:Diagnosis, Differential; D005260:Female; D005534:Foot Diseases; D006801:Humans; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local; D012878:Skin Neoplasms / Q000145:classification / Q000175:diagnosis* / Q000601:surgery