title: A new method for the protection of carboxylic acids with a triisopropylsiloxymethyl group.
abstract: An effective method for the protection of carboxylic acids with a triisopropylsiloxymethyl (TIPSOCH(2)) group is described. The reactions of various carboxylic acids with C(12)H(25)SCH(2)OTIPS in the presence of CuBr(2), Et(3)N, and molecular sieves 4A afford the corresponding triisopropylsiloxymethyl esters in good yields.
authors.affiliation: Graduate School of Biomedical Sciences, Nagasaki University, 1-14 Bunkyo-machi, Nagasaki 852-8521, Japan.
authors.forename: Hikaru
authors.initials: H
authors.lastname: Yoshimura
authors.forename: Kohei
authors.initials: K
authors.lastname: Eto
authors.forename: Keisuke
authors.initials: K
authors.lastname: Takahashi
authors.forename: Jun
authors.initials: J
authors.lastname: Ishihara
authors.forename: Susumi
authors.initials: S
authors.lastname: Hatakeyama
mesh_terms: D000438:Alcohols / Q000737:chemistry; D000596:Amino Acids / Q000737:chemistry; D002264:Carboxylic Acids / Q000737:chemistry*; D004952:Esters / Q000737:chemistry; D017646:Organosilicon Compounds / Q000737:chemistry*
chemical_list: D000438:Alcohols; D000596:Amino Acids; D002264:Carboxylic Acids; D004952:Esters; D017646:Organosilicon Compounds