title: Tumor necrosis factor-alpha and the cytokine network in psoriasis.
abstract: New molecular methods of research have greatly expanded the knowledge about the role of cytokines in several diseases, including psoriasis. The work orchestrated by these peptides is essential for the communication between resident inflammatory cells (keratinocytes and endothelial cells) and infiltrating cells (neutrophils, lymphocytes, Langerhans cells). This is a complex network due to redundancy, synergism and, sometimes, the antagonism of cytokines, which prevents full understanding of the pathogenesis of the disease. Currently, it seems premature to try to establish a main actor, but TNFalpha participates in all stages of psoriatic plaque development, as we shall see.
authors.affiliation: Dermatology Service, Marcilio Dias Naval Hospital, Rio de Janeiro, Brazil. arlesbrotas@gmail.com
authors.forename: Arles Martins
authors.initials: AM
authors.lastname: Brotas
authors.forename: José Marcos Tellas
authors.initials: JM
authors.lastname: Cunha
authors.forename: Eduardo Henrique Jorge
authors.initials: EH
authors.lastname: Lago
authors.forename: Cristiane Chaves Nascentes
authors.initials: CC
authors.lastname: Machado
authors.forename: Sueli Coelho da Silva
authors.initials: SC
authors.lastname: Carneiro
mesh_terms: D002450:Cell Communication / Q000276:immunology*; D016207:Cytokines / Q000502:physiology; D006801:Humans; D015603:Keratinocytes / Q000276:immunology; D011565:Psoriasis / Q000276:immunology*; D014409:Tumor Necrosis Factor-alpha / Q000276:immunology*
chemical_list: D016207:Cytokines; D014409:Tumor Necrosis Factor-alpha