title: Effects of early life stress on brain activity: implications from maternal separation model in rodents.
abstract: Adverse experiences in early life can affect the formation of neuronal circuits during postnatal development and exert long-lasting influences on neural function. Many studies have shown that daily repeated maternal separation (RMS), an animal model of early life stress, can modulate the hypothalamic-pituitary-adrenal axis (HPA-axis) and can affect subsequent brain function and emotional behavior during adulthood. However, the molecular basis of the long-lasting effects of early life stress on brain function has not been completely elucidated. In this mini-review, we introduce various cases of maternal separation in rodents and illustrate the alterations in HPA-axis activity by focusing on corticosterone (CORT), an end-product of the HPA-axis in rodents. We then present the characterization of the brain regions affected by various patterns of MS, including RMS and single time maternal separation (SMS) at various stages before weaning, by investigating c-Fos expression, a biological marker of neuronal activity. These CORT and c-Fos studies suggest that repeated early life stress may affect neuronal function in region- and temporal-specific manners, indicating a critical period for habituation to early life stress. Furthermore, we introduce changes in behavioral aspects and gene expression in adult mice exposed to RMS.
authors.affiliation: Department of Anatomy and Cell Biology, Faculty of Medicine, Nara Medical University, Kashihara, Nara 634-8521, Japan. nmayumi@naramed-u.ac.jp
authors.forename: Mayumi
authors.initials: M
authors.lastname: Nishi
authors.forename: Noriko
authors.initials: N
authors.lastname: Horii-Hayashi
authors.forename: Takayo
authors.initials: T
authors.lastname: Sasagawa
authors.forename: Wataru
authors.initials: W
authors.lastname: Matsunaga
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D001921:Brain / Q000378:metabolism* / Q000502:physiology*; D003345:Corticosterone / Q000378:metabolism; D005260:Female; D051379:Mice; D016760:Proto-Oncogene Proteins c-fos / Q000378:metabolism; D013315:Stress, Psychological / Q000378:metabolism* / Q000503:physiopathology*
chemical_list: D016760:Proto-Oncogene Proteins c-fos; D003345:Corticosterone