title: Homo- and heterodimeric Smac mimetics/IAP inhibitors as in vivo-active pro-apoptotic agents. Part I: Synthesis.
abstract: Novel pro-apoptotic, homo- and heterodimeric Smac mimetics/IAPs inhibitors based on the N-AVPI-like 4-substituted 1-aza-2-oxobicyclo[5.3.0]decane scaffold were prepared from monomeric structures connected through a head-head (8), tail-tail (9) or head-tail (10) linker. The selection of appropriate decorating functions for the scaffolds, and of rigid and flexible linkers connecting them, is described. The synthesis, purification and analytical characterization of each prepared dimer 8-10 is thoroughly described.
authors.affiliation: Istituto di Scienze e Tecnologie Molecolari (ISTM), Consiglio Nazionale delle Ricerche (CNR), Via Golgi 19, Milan, Italy.
authors.forename: Leonardo
authors.initials: L
authors.lastname: Manzoni
authors.forename: Laura
authors.initials: L
authors.lastname: Belvisi
authors.forename: Aldo
authors.initials: A
authors.lastname: Bianchi
authors.forename: Annalisa
authors.initials: A
authors.lastname: Conti
authors.forename: Carmelo
authors.initials: C
authors.lastname: Drago
authors.forename: Marilenia
authors.initials: M
authors.lastname: de Matteo
authors.forename: Luca
authors.initials: L
authors.lastname: Ferrante
authors.forename: Eloise
authors.initials: E
authors.lastname: Mastrangelo
authors.forename: Paola
authors.initials: P
authors.lastname: Perego
authors.forename: Donatella
authors.initials: D
authors.lastname: Potenza
authors.forename: Carlo
authors.initials: C
authors.lastname: Scolastico
authors.forename: Federica
authors.initials: F
authors.lastname: Servida
authors.forename: Gabriele
authors.initials: G
authors.lastname: Timpano
authors.forename: Francesca
authors.initials: F
authors.lastname: Vasile
authors.forename: Vincenzo
authors.initials: V
authors.lastname: Rizzo
authors.forename: Pierfausto
authors.initials: P
authors.lastname: Seneci
mesh_terms: D040761:Biomimetic Materials / Q000138:chemical synthesis* / Q000737:chemistry; D019281:Dimerization; D051034:Inhibitor of Apoptosis Proteins / Q000037:antagonists & inhibitors* / Q000378:metabolism; D009842:Oligopeptides / Q000737:chemistry*
chemical_list: D051034:Inhibitor of Apoptosis Proteins; D009842:Oligopeptides; C532637:SMAC peptide