title: Predicting mortality and cost of hematopoietic stem-cell transplantation.
abstract: OBJECTIVE
  To evaluate whether the Pretransplantion Assesment of Mortality risk score is associated to transplant costs and can be used not only to predict mortality but also as a cost management tool.
  
  
  METHODS
  We evaluated consecutively patients submitted to allogeneic (n = 27) and autologous (n = 89) hematopoietic stem cell-transplantation from 2004 to 2006 at Hospital Israelita Albert Einstein (SP), Brazil. Participants mean age at hematopoietic stem cell-transplantation was 42 (range 1 to 72) years; there were 69 males and 47 females; 30 patients had multiple myeloma; 41 had non-Hodgkin and Hodgkin's lymphomas; 22 had acute leukemia; 6 had chronic leukemia; and 17 had non-malignant disease. The Pretransplantion Assesment of Mortality risk score was applied in all patients using the available web site (http://cdsweb.fhcrc.org/ pam/).
  
  
  RESULTS
  Patients could be classified in three risk categories: high, intermediate and low, having significant difference in survival (p = 0.0162). The median cost in US dollars for each group was $ 281.000, $ 73.300 and $ 54.400 for high, intermediate and low risk, respectively. The cost of hematopoietic stem cell-transplantation significantly differed for each Pretransplantin Assesment of Mortality risk group (p = 0.008).
  
  
  CONCLUSIONS
  The validation of the Pretransplantion Assesment of Mortality risk score in our patients confirmed that this system is an important tool to be used in transplantation units, being easy to apply and fully reproducible.
authors.affiliation: Hospital Israelita Albert Einstein - HIAE, São Paulo (SP), Brazil. fkerbauy@einstein.br
authors.forename: Fábio Rodrigues
authors.initials: FR
authors.lastname: Kerbauy
authors.forename: Leonardo Raul
authors.initials: LR
authors.lastname: Morelli
authors.forename: Cláudia Toledo
authors.initials: CT
authors.lastname: de Andrade
authors.forename: Luis Fernando
authors.initials: LF
authors.lastname: Lisboa
authors.forename: Miguel
authors.initials: M
authors.lastname: Cendoroglo Neto
authors.forename: Nelson
authors.initials: N
authors.lastname: Hamerschlak
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001938:Brazil / Q000453:epidemiology; D002648:Child; D002675:Child, Preschool; D003365:Costs and Cost Analysis; D005260:Female; D005544:Forecasting; D005102:Health Expenditures; D006402:Hematologic Diseases / Q000601:surgery; D019337:Hematologic Neoplasms / Q000601:surgery; D018380:Hematopoietic Stem Cell Transplantation / Q000191:economics* / Q000401:mortality*; D006801:Humans; D007223:Infant; D008297:Male; D008875:Middle Aged; D011300:Preoperative Care; D012189:Retrospective Studies; D012306:Risk; D012720:Severity of Illness Index; D014182:Transplantation, Autologous; D014184:Transplantation, Homologous; D055815:Young Adult