title: [MRI enterography in the assessment of paediatric Crohn's disease].
abstract: OBJECTIVE
  To determine the usefulness of MRI enterography for assessing the extension and activity of paediatric Crohn's disease. MRI findings were compared with clinical, biological, endoscopic and other imaging data.
  
  
  METHODS
  Studies of MRI enterography use in patients younger than 18 years of age were reviewed. Patients received 500-1000mL of polyethylene glycol one hour before examination (1.5-TMR). T2 HASTE sequences with or without fat saturation, T2 true-FISP, T1 with fat saturation, pre- and post gadolinium-enhanced VIBE sequences, and dynamic and diffusion HASTE were acquired. Thickening of the bowel wall, mucosal enhancement, and extra-luminal complications were evaluated. Five MRI patterns (normal, fibrosis, mild, moderate, and severe transmural activity) were defined. Findings were compared with PCDAI scores, inflammatory parameters, and endoscopic and histological results.
  
  
  RESULTS
  Twenty-two studies were reviewed. Optimal intestinal distension was present in 82% of the cases. Mild side effects were observed in 12% of patients. There was a significant relationship between MRI patterns and PCDAI scores (P=.002), sedimentation rate (P=.006) and serum PCR levels (P=.047) and a non-significant relationship with the histology (P=.571). MRI enterography correctly assessed the ileal (80%) and colonic (66%) extension. Extra-luminal complications unrelated to MRI classification (P=.274) were reported in 86.4% of studies.
  
  
  CONCLUSIONS
  There was a significant relationship between MRI patterns and PCR, sedimentation rate, and PCDAI scores. MRI enterography showed excellent agreement with ileoscopies, and allowed endoscopically non-accessible areas to be assessed, as well as the diagnosis of extra-luminal complications without irradiation.
authors.affiliation: Unidad de Gastroenterología, Hepatología y Nutrición Pediátrica, Servicio de Pediatría, Hospital Universitari Vall d'Hebron, Barcelona, Spain. : alvarezbeltran@hotmail.com
authors.forename: M
authors.initials: M
authors.lastname: Alvarez Beltran
authors.forename: I
authors.initials: I
authors.lastname: Barber Martinez de la Torre
authors.forename: O
authors.initials: O
authors.lastname: Segarra Cantón
authors.forename: S
authors.initials: S
authors.lastname: Redecillas Ferreiro
authors.forename: A
authors.initials: A
authors.lastname: Castellote Alonso
authors.forename: D
authors.initials: D
authors.lastname: Infante Pina
mesh_terms: D000293:Adolescent; D003424:Crohn Disease / Q000175:diagnosis*; D003938:Diagnostic Techniques, Digestive System; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D011446:Prospective Studies