title: A case of daptomycin-induced immune thrombocytopenia.
abstract: We report a case of severe daptomycin-induced immune thrombocytopenia in a patient treated for methicillin-resistant Staphylococcus epidermidis and ampicillin-resistant Enterococcus faecalis bacteremia acquired in an intensive care unit. Serum antibodies bound to platelets in the presence of daptomycin on flow cytometry. There was no evidence of other causes of thrombocytopenia. The patient died of brain herniation complicating extensive cerebral hemorrhage. To our knowledge, this is the first described case of daptomycin-induced thrombocytopenia.
authors.affiliation: Intensive Care Unit, Saint Joseph Hospital Network, Paris, France. charles.gregoire@gmail.com
authors.forename: Charles
authors.initials: C
authors.lastname: Grégoire
authors.forename: Caren
authors.initials: C
authors.lastname: Brumpt
authors.forename: Delphine
authors.initials: D
authors.lastname: Loirat
authors.forename: Nicolas
authors.initials: N
authors.lastname: Lau
authors.forename: Cedric
authors.initials: C
authors.lastname: Bruel
authors.forename: Francois
authors.initials: F
authors.lastname: Philippart
authors.forename: Carine
authors.initials: C
authors.lastname: Couzigou
authors.forename: Maité
authors.initials: M
authors.lastname: Garrouste-Orgeas
authors.forename: Benoit
authors.initials: B
authors.lastname: Misset
mesh_terms: D018784:Abdominal Abscess / Q000188:drug therapy / Q000382:microbiology; D000668:Ampicillin Resistance; D000900:Anti-Bacterial Agents / Q000009:adverse effects* / Q000627:therapeutic use; D017576:Daptomycin / Q000009:adverse effects* / Q000627:therapeutic use; D013293:Enterococcus faecalis; D017809:Fatal Outcome; D005434:Flow Cytometry; D016908:Gram-Positive Bacterial Infections / Q000150:complications / Q000188:drug therapy; D006801:Humans; D020300:Intracranial Hemorrhages / Q000209:etiology; D008297:Male; D008642:Mesenteric Veins; D055624:Methicillin-Resistant Staphylococcus aureus; D008875:Middle Aged; D017713:Platelet Transfusion; D011552:Pseudomonas Infections / Q000150:complications / Q000188:drug therapy; D012772:Shock, Septic / Q000150:complications / Q000188:drug therapy; D013203:Staphylococcal Infections / Q000150:complications / Q000188:drug therapy; D013921:Thrombocytopenia / Q000139:chemically induced* / Q000276:immunology / Q000628:therapy; D020246:Venous Thrombosis / Q000150:complications
chemical_list: D000900:Anti-Bacterial Agents; D017576:Daptomycin