title: On the proposed structures and stereocontrolled synthesis of the cephalosporolides.
abstract: The synthesis of four candidate stereoisomers of cephalosporolide H is described, made possible by a zinc-chelation strategy for controlling the stereochemistry of oxygenated 5,5-spiroketals. The same strategy likewise enables the first stereocontrolled synthesis of cephalosporolide E, which is typically isolated and prepared admixed with its spiroketal epimer, cephalosporolide F.
authors.affiliation: Department of Chemistry and Biochemistry, Florida State University, Tallahassee, FL 32306-4390 USA.
authors.forename: Sami F
authors.initials: SF
authors.lastname: Tlais
authors.forename: Gregory B
authors.initials: GB
authors.lastname: Dudley