title: Synthesis of the originally proposed structure of palmerolide C.
abstract: A stereoselective synthesis of the proposed structure of palmerolide C (1), a cytotoxic marine macrolide isolated from the Antarctic tunicate Synoicum adareanum, utilizes a convergent carbonyl-based coupling strategy to construct the C1-C24 carbon skeleton (see scheme). Compound 1 was shown to be a diastereomer of palmerolide C, and the structural revision of the natural product is proposed.
authors.affiliation: EaStCHEM School of Chemistry, University of St Andrews, North Haugh, St Andrews, KY16 9ST, UK. gjf1@st-andrews.ac.uk
authors.forename: Gordon J
authors.initials: GJ
authors.lastname: Florence
authors.forename: Joanna
authors.initials: J
authors.lastname: Wlochal
mesh_terms: D000818:Animals; D018942:Macrolides / Q000138:chemical synthesis* / Q000737:chemistry; D009682:Magnetic Resonance Spectroscopy; D008968:Molecular Conformation; D013237:Stereoisomerism; D014561:Urochordata / Q000737:chemistry
chemical_list: D018942:Macrolides; C579527:palmerolide C