title: Lobarin from the Sumatran lichen, Stereocaulon halei.
abstract: The diphenyl ether, lobarin (1) (syn. lobariol carboxylic acid) related to lobaric acid was isolated for the first time as a natural product along with five known compounds from Stereocaulon halei, a fruticose lichen collected in Indonesia. The structure of lobarin was elucidated by spectroscopic data analysis and its most stable conformers were determined by molecular mechanic dynamic calculations. A marked superoxide anion scavenging was found for compound 1 while no cytotoxicity on the B16 murine melanoma and HaCaT human keratinocyte cell lines was observed.
authors.affiliation: UMR CNRS 6226 ISCR, Equipe PNSCM, Faculté des Sciences Pharmaceutiques et Biologiques, Univ. Rennes 1, 35043 Rennes Cedex, France.
authors.forename: Friardi
authors.initials: F
authors.lastname: Ismed
authors.forename: Françoise
authors.initials: F
authors.lastname: Lohézic-Le Dévéhat
authors.forename: Olivier
authors.initials: O
authors.lastname: Delalande
authors.forename: Sourisak
authors.initials: S
authors.lastname: Sinbandhit
authors.forename: Amri
authors.initials: A
authors.lastname: Bakhtiar
authors.forename: Joël
authors.initials: J
authors.lastname: Boustie
mesh_terms: D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry* / Q000494:pharmacology*; D045744:Cell Line, Tumor; D006801:Humans; D008011:Lichens / Q000737:chemistry*; D051379:Mice; D010647:Phenyl Ethers / Q000737:chemistry* / Q000494:pharmacology*
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D010647:Phenyl Ethers; C581171:lobarin