title: Mobilization of hematopoietic progenitor cells with granulocyte colony stimulating factors for autologous transplant in hematologic malignancies: a single center experience.
abstract: BACKGROUND
  In 2006 the Hematology Service of Hospital Maciel published its experience with peripheral blood progenitor cell harvesting for autologous stem cell transplantation using Filgen JP (Clausen Filgrastim). After mobilization with a mean filgrastim dose of 78 mcg/Kg, 4.7 x 10(6) CD34(+) cells/Kg were obtained by apheresis. Age above 50, multiple myeloma as underlying disease and a malignancy that was not in remission were identified as frequent characteristics among patients showing complex mobilization.
  
  
  OBJECTIVE
  The aim of this study was to compare stem cell mobilization using different brands of filgrastim.
  
  
  METHODS
  One hundred and fifty-seven mobilizations performed between 1997 and 2006 were analyzed. This retrospective analysis comparative two groups of patients: those mobilized with different brands of filgrastim (Group A) and those who received Filgen JP (Clausen Filgrastim) as mobilizing agent (Group B). A cluster analysis technique was used to identify four clusters of individuals with different behaviors differentiated by age, total dose of filgrastim required, number of apheresis and harvested CD34(+) cells.
  
  
  RESULTS
  The mean total dose of filgrastim administered was 105 mcg/Kg, the median number of apheresis was 2 procedures and the mean number of harvested stem cells was 4.98 x 10(6) CD34(+) cells/Kg. No significant differences were observed between Groups A and B regarding the number of apheresis, harvested CD34(+) cells and number of mobilization failures, however the total dose of filgrastim was significantly lower in Group B.
  
  
  CONCLUSIONS
  Among other factors, the origin of the cytokine used as mobilizing agent is an element to be considered when evaluating CD34(+) cell mobilization results.
authors.affiliation: Hematology Service, Hospital Maciel, Montevideo, Uruguay.
authors.forename: Raul
authors.initials: R
authors.lastname: Gabús
authors.forename: Gabriel
authors.initials: G
authors.lastname: Borelli
authors.forename: Martín
authors.initials: M
authors.lastname: Ferrando
authors.forename: Enrique
authors.initials: E
authors.lastname: Bódega
authors.forename: Estela
authors.initials: E
authors.lastname: Citrín
authors.forename: Constanza Olivera
authors.initials: CO
authors.lastname: Jiménez
authors.forename: Ramón
authors.initials: R
authors.lastname: Alvarez