title: Genetic counseling in melanoma.
abstract: Genetic counseling may be offered to families with melanoma and to individuals with multiple melanomas to better understand the genetic susceptibility of the disease, the influence of environmental factors, the inheritance of the risk, and behavior that decreases the risk of dying from melanoma, including specific dermatological follow-up such as total body photography and digital dermoscopy. Genetic testing may be offered to those individuals with more than a 10% chance of being a carrier of a mutation. This risk varies according to the incidence of melanoma in the country and sun behavior. In countries with a low-medium incidence of melanoma, genetic testing should be offered to families with two cases of melanoma or an individual with two primary melanomas. In countries with a high incidence, families with three cases of melanoma, with two melanomas and one pancreatic adenocarcinoma, or patients with three primary melanomas, may benefit from genetic testing.
authors.affiliation: Centro Investigación Biomédica en Red en Enfermedades Raras (CIBERER), Biochemical and Molecular Genetics Service, Melanoma Unit, Hospital Clinic, Villarroel, Barcelona, Spain. cbadenas@clinic.ub.es
authors.forename: Celia
authors.initials: C
authors.lastname: Badenas
authors.forename: Paula
authors.initials: P
authors.lastname: Aguilera
authors.forename: Joan A
authors.initials: JA
authors.lastname: Puig-Butillé
authors.forename: Cristina
authors.initials: C
authors.lastname: Carrera
authors.forename: Josep
authors.initials: J
authors.lastname: Malvehy
authors.forename: Susana
authors.initials: S
authors.lastname: Puig
mesh_terms: D046169:Dermoscopy / Q000379:methods; D005192:Family Health / Q000706:statistics & numerical data; D005817:Genetic Counseling / Q000379:methods*; D020022:Genetic Predisposition to Disease; D005820:Genetic Testing / Q000379:methods; D015438:Health Behavior; D006801:Humans; D015994:Incidence; D008545:Melanoma / Q000453:epidemiology / Q000235:genetics* / Q000473:pathology; D009154:Mutation; D010781:Photography / Q000379:methods; D012307:Risk Factors; D012878:Skin Neoplasms / Q000453:epidemiology / Q000235:genetics* / Q000473:pathology