title: Characterisation of a group of endogenous gammaretroviruses in the canine genome.
abstract: Bioinformatics were used to identify and characterise 39 pol, 34 gag and five env gammaretroviruses within the canine (Canis lupus familiaris) reference genome. These endogenous retroviruses are monophyletic to the Canidae, predate the divergence of dogs and foxes and are fixed in 20 canine breeds examined. They are transcribed in normal canine tissue but are unlikely to be replication competent in dogs.
authors.affiliation: School of Veterinary Medicine and Science, University of Nottingham, Sutton Bonington Campus, Leicestershire LE12 5RD, UK. rachael.tarlinton@nottingham.ac.uk
authors.forename: Rachael E
authors.initials: RE
authors.lastname: Tarlinton
authors.forename: Hannah K R
authors.initials: HK
authors.lastname: Barfoot
authors.forename: Ceri E
authors.initials: CE
authors.lastname: Allen
authors.forename: Katherine
authors.initials: K
authors.lastname: Brown
authors.forename: Robert J
authors.initials: RJ
authors.lastname: Gifford
authors.forename: Richard D
authors.initials: RD
authors.lastname: Emes
mesh_terms: D000818:Animals; D004285:Dogs / Q000235:genetics* / Q000821:virology*; D020077:Endogenous Retroviruses / Q000235:genetics*; D005260:Female; D017988:Gammaretrovirus / Q000235:genetics*; D016678:Genome; D008297:Male; D009928:Organ Specificity; D010802:Phylogeny; D060888:Real-Time Polymerase Chain Reaction / Q000662:veterinary; D020133:Reverse Transcriptase Polymerase Chain Reaction / Q000662:veterinary; D020539:Sequence Analysis, Protein / Q000662:veterinary