title: Four tandem C-H activations: a sequential C-C and C-O bond making via a Pd-catalyzed cross dehydrogenative coupling (CDC) approach.
abstract: An unprecedented aroylation at the ortho C-H bond with respect to a directing group has been accomplished via a Pd(II)-catalyzed cross dehydrogenative coupling approach using alkylbenzene as the synthetic equivalent of an aroyl moiety. The reaction proceeds through sequential C-C and C-O bond making at the expense of four consecutive C-H bond cleavages (three sp(3) benzylic C-H's and one sp(2) arene C-H) to selectively install an aroyl functionality at the proximal site of substrates containing various directing groups.
authors.affiliation: Department of Chemistry, Indian Institution of Technology Guwahati, Guwahati 781 039, India.
authors.forename: Srimanta
authors.initials: S
authors.lastname: Guin
authors.forename: Saroj Kumar
authors.initials: SK
authors.lastname: Rout
authors.forename: Arghya
authors.initials: A
authors.lastname: Banerjee
authors.forename: Shyamapada
authors.initials: S
authors.lastname: Nandi
authors.forename: Bhisma K
authors.initials: BK
authors.lastname: Patel