title: Identifying the intermolecular hydrogen-bonding supramolecular synthons in an indomethacin-nicotinamide cocrystal by solid-state NMR.
abstract: Two-dimensional (1)H double-quantum and (14)N-(1)H & (1)H-(13)C heteronuclear magic-angle spinning (MAS) NMR spectra recorded at natural isotopic abundance identify specific intermolecular COOH···N(arom) and CH(arom)···O=C hydrogen-bonding interactions in the solid-state structure of an indomethacin-nicotinamide cocrystal, thus additionally proving cocrystal formation.
authors.affiliation: Department of Physics, University of Warwick, Coventry CV4 7AL, UK.
authors.forename: Keisuke
authors.initials: K
authors.lastname: Maruyoshi
authors.forename: Dinu
authors.initials: D
authors.lastname: Iuga
authors.forename: Oleg N
authors.initials: ON
authors.lastname: Antzutkin
authors.forename: Amjad
authors.initials: A
authors.lastname: Alhalaweh
authors.forename: Sitaram P
authors.initials: SP
authors.lastname: Velaga
authors.forename: Steven P
authors.initials: SP
authors.lastname: Brown
mesh_terms: D003460:Crystallization; D006860:Hydrogen Bonding; D007213:Indomethacin / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy / Q000379:methods; D009536:Niacinamide / Q000737:chemistry*
chemical_list: D009536:Niacinamide; D007213:Indomethacin