title: Two distinct epitopes on the ovalbumin 323-339 peptide differentiating CD4⁺T cells into the Th2 or Th1 phenotype.
abstract: The epitopes for OVA323-339-specific CD4⁺T cells from OVA23-3 food allergy model and DO11.10 tolerant induction model mice were analyzed. We found that OVA23-3 CD4⁺T cells recognized the N-terminal region, showing strong proliferation and the Th2-phenotype, and that DO11.10 CD4⁺T cells recognized the C-terminal region, showing milder proliferation and a Th1-skewed response. These differences may regulate the responses of those mice to OVA-feeding, inflammation and tolerance.
authors.affiliation: Research Center for Food Safety, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo, Japan. aryu@mail.ecc.u-tokyo.ac.jp
authors.forename: Haruyo
authors.initials: H
authors.lastname: Nakajima-Adachi
authors.forename: Emiko
authors.initials: E
authors.lastname: Koike
authors.forename: Mamoru
authors.initials: M
authors.lastname: Totsuka
authors.forename: Erika
authors.initials: E
authors.lastname: Hiraide
authors.forename: Yoshio
authors.initials: Y
authors.lastname: Wakatsuki
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Kiyono
authors.forename: Satoshi
authors.initials: S
authors.lastname: Hachimura
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D015496:CD4-Positive T-Lymphocytes / Q000166:cytology* / Q000276:immunology; D002454:Cell Differentiation / Q000276:immunology*; D000939:Epitopes / Q000737:chemistry / Q000276:immunology*; D005512:Food Hypersensitivity / Q000276:immunology; D051379:Mice; D008969:Molecular Sequence Data; D010047:Ovalbumin / Q000737:chemistry*; D010446:Peptide Fragments / Q000737:chemistry / Q000276:immunology*; D010641:Phenotype; D018417:Th1 Cells / Q000166:cytology*; D018418:Th2 Cells / Q000166:cytology*
chemical_list: D000939:Epitopes; D010446:Peptide Fragments; D010047:Ovalbumin