title: PPARs Signaling and Cancer in the Gastrointestinal System.
abstract: Nowadays, the study of the peroxisome proliferators activated receptors (PPARs) as potential targets for cancer prevention and therapy has gained a strong interest. From a biological point of view, the overall responsibility of PPARs in cancer development and progression is still controversial since several studies report both antiproliferative and tumor-promoting actions for these signaling molecules in human cancer cells and animal models. In this paper, we discuss PPARs functions in the context of different types of gastrointestinal cancer.
authors.affiliation: Gastroenterology Unit IRCCS "Casa Sollievo della Sofferenza" Hospital, Viale dei Cappuccini n.1, 71013 San Giovanni Rotondo, Italy.
authors.forename: Valerio
authors.initials: V
authors.lastname: Pazienza
authors.forename: Manlio
authors.initials: M
authors.lastname: Vinciguerra
authors.forename: Gianluigi
authors.initials: G
authors.lastname: Mazzoccoli