title: Non-HIV Kaposi's sarcoma: a review and therapeutic perspectives.
abstract: "Classic" Kaposi's sarcoma (CKS) not related to HIV is a multifocal angioproliferative neoplasm that is linked to human herpesvirus. CKS is a cutaneous cancer frequently occurring with an indolent course. However, it can compromise the quality of life by causing pain, disfigurement and functional disability. For this reason, the main treatment goals are not only to reduce the cutaneous lesions but also to alleviate organ involvement and psychological stress by delaying disease progression and ultimately cure. This report summarizes systemic treatment options of CKS, including chemotherapy, immunotherapy and anti-HHV8 therapy. In addition, this review will focus on the recent understanding of carcinogenesis and consequently highlight potential "targeted" therapeutic interventions.
authors.affiliation: Hassan II University Hospital, Medical Oncology Department, Morocco. you.yous@hotmail.fr
authors.forename: Yousra
authors.initials: Y
authors.lastname: Akasbi
authors.forename: Ahmad
authors.initials: A
authors.lastname: Awada
authors.forename: Samia
authors.initials: S
authors.lastname: Arifi
authors.forename: Nawfal
authors.initials: N
authors.lastname: Mellas
authors.forename: Omar
authors.initials: O
authors.lastname: El Mesbahi
mesh_terms: D000367:Age Factors; D000970:Antineoplastic Agents / Q000627:therapeutic use; D000998:Antiviral Agents / Q000627:therapeutic use; D005260:Female; D019288:Herpesvirus 8, Human; D006801:Humans; D008297:Male; D058990:Molecular Targeted Therapy / Q000379:methods; D012514:Sarcoma, Kaposi / Q000188:drug therapy* / Q000453:epidemiology / Q000473:pathology / Q000821:virology; D012737:Sex Factors; D012878:Skin Neoplasms / Q000188:drug therapy* / Q000453:epidemiology / Q000473:pathology / Q000821:virology; D013792:Thalidomide / Q000627:therapeutic use
chemical_list: D000970:Antineoplastic Agents; D000998:Antiviral Agents; D013792:Thalidomide