title: A potential link between obesity and neural stem cell dysfunction.
abstract: Given the important role of the hypothalamus in regulating feeding and metabolism, there has been considerable interest in a possible function for hypothalamic stem cells in modulating body weight in health and disease. Mice given a high-fat diet develop inflammation in the hypothalamus and lose key types of neurons. It now appears that another effect of a high-fat diet is to reduce neural stem cell numbers, as well as their ability to make new neurons--effects that are associated with activation of the IKKβ/NF-κB pathway--thereby exacerbating the primary loss of neurons and resulting in altered feeding behaviour and obesity.
authors.forename: Frederick J
authors.initials: FJ
authors.lastname: Livesey
mesh_terms: D000818:Animals; D059305:Diet, High-Fat; D005247:Feeding Behavior / Q000502:physiology; D007031:Hypothalamus / Q000503:physiopathology; D051550:I-kappa B Kinase / Q000502:physiology; D051379:Mice; D016328:NF-kappa B / Q000502:physiology; D058953:Neural Stem Cells / Q000502:physiology*; D009765:Obesity / Q000503:physiopathology*; D015398:Signal Transduction / Q000502:physiology
chemical_list: D016328:NF-kappa B; D051550:I-kappa B Kinase