title: Using smell to triage samples in point-of-care assays.
abstract: Smell of success: Reagent 1 provides the dual readouts of odor (ethanethiol) and fluorescence (derivative of 7-hydroxycoumarin) and can be used in down-selection assays based on smell and quantitative fluorescence assays of the samples that give a positive result. An important feature of 1 is the matched sensitivity of the two outputs. This reagent is designed for use in resource-limited settings and is demonstrated in assays that detect enzymes.
authors.affiliation: Department of Chemistry, The Pennsylvania State University, University Park, PA 16802, USA.
authors.forename: Hemakesh
authors.initials: H
authors.lastname: Mohapatra
authors.forename: Scott T
authors.initials: ST
authors.lastname: Phillips
mesh_terms: D001897:Boronic Acids / Q000138:chemical synthesis / Q000737:chemistry*; D005453:Fluorescence; D006801:Humans; D006861:Hydrogen Peroxide / Q000737:chemistry; D015394:Molecular Structure; D019095:Point-of-Care Systems; D012903:Smell; D013438:Sulfhydryl Compounds / Q000737:chemistry*; D014468:Umbelliferones / Q000737:chemistry*
chemical_list: D001897:Boronic Acids; D013438:Sulfhydryl Compounds; D014468:Umbelliferones; C031477:7-hydroxycoumarin; D006861:Hydrogen Peroxide; C007638:ethanethiol