title: Circulating heat shock protein 60 levels are elevated in HIV patients and are reduced by anti-retroviral therapy.
abstract: Circulating heat shock protein 60 (Hsp60) and heat shock protein 10 (Hsp10) have been associated with pro- and anti-inflammatory activity, respectively. To determine whether these heat shock proteins might be associated with the immune activation seen in HIV-infected patients, the plasma levels of Hsp60 and Hsp10 were determined in a cohort of 20 HIV-infected patients before and after effective combination anti-retroviral therapy (cART). We show for the first time that circulating Hsp60 levels are elevated in HIV-infected patients, with levels significantly reduced after cART, but still higher than those in HIV-negative individuals. Hsp60 levels correlated significantly with viral load, CD4 counts, and circulating soluble CD14 and lipopolysaccharide levels. No differences or correlations were seen for Hsp10 levels. Elevated circulating Hsp60 may contribute to the immune dysfunction and non-AIDS clinical events seen in HIV-infected patients.
authors.affiliation: Queensland Institute of Medical Research, Brisbane, Queensland, Australia.
authors.forename: Itaru
authors.initials: I
authors.lastname: Anraku
authors.forename: Reena
authors.initials: R
authors.lastname: Rajasuriar
authors.forename: Caroline
authors.initials: C
authors.lastname: Dobbin
authors.forename: Richard
authors.initials: R
authors.lastname: Brown
authors.forename: Sharon R
authors.initials: SR
authors.lastname: Lewin
authors.forename: Andreas
authors.initials: A
authors.lastname: Suhrbier
mesh_terms: D000328:Adult; D044966:Anti-Retroviral Agents / Q000627:therapeutic use*; D023241:Antiretroviral Therapy, Highly Active; D018791:CD4 Lymphocyte Count; D018835:Chaperonin 10 / Q000097:blood / Q000235:genetics / Q000276:immunology; D018834:Chaperonin 60 / Q000097:blood* / Q000235:genetics / Q000276:immunology; D005260:Female; D015870:Gene Expression; D006678:HIV / Q000187:drug effects / Q000502:physiology*; D015658:HIV Infections / Q000097:blood* / Q000188:drug therapy / Q000276:immunology / Q000821:virology; D006801:Humans; D018950:Lipopolysaccharide Receptors / Q000097:blood; D008070:Lipopolysaccharides / Q000097:blood; D008297:Male; D008875:Middle Aged; D019562:Viral Load / Q000187:drug effects
chemical_list: D044966:Anti-Retroviral Agents; D018835:Chaperonin 10; D018834:Chaperonin 60; D018950:Lipopolysaccharide Receptors; D008070:Lipopolysaccharides