title: [Multikinase inhibitor sorafenib and HDAC inhibitor suberoylanilide hydroxamic acid suppress confluent resistance of cancer cells to recombinant protein izTRAIL].
abstract: Suppression of human tumor cell resistance to TRAIL-induced apoptosis in confluent cultures, using molecular target drugs (sorafenib and SAHA) at non-toxic concentrations was studied. Sorafenib, a multikinase inhibitor, and SAHA, an inhibitor of histone deacetylase, effectively suppressed resistance of confluent human cells derived from the skin carcinoma (A431 cell line) and fibrosarcoma (HT-1080 cell line). The effectiveness of suppression of confluent resistance with these inhibitors for human carcinoma A431 cells was significantly higher than that for the human ovarian carcinoma OVCAR-3 cells. For all cell lines studied, suppression of confluent resistance with SAHA was more effective than when sorafenib was used. The possible reason for increasing tumor cell resistance in confluent cultures and the importance of this phenomenon for understanding drug resistance of cells in the tumor tissue are discussed.
authors.forename: R S
authors.initials: RS
authors.lastname: Fadeev
authors.forename: A V
authors.initials: AV
authors.lastname: Chekanov
authors.forename: N V
authors.initials: NV
authors.lastname: Dolgikh
authors.forename: V S
authors.initials: VS
authors.lastname: Akatov
mesh_terms: D001557:Benzenesulfonates / Q000494:pharmacology; D018929:Cell Culture Techniques; D045744:Cell Line, Tumor; D019008:Drug Resistance, Neoplasm / Q000187:drug effects*; D056572:Histone Deacetylase Inhibitors / Q000494:pharmacology; D006801:Humans; D006877:Hydroxamic Acids / Q000494:pharmacology; D009536:Niacinamide / Q000031:analogs & derivatives; D010671:Phenylurea Compounds; D047428:Protein Kinase Inhibitors / Q000494:pharmacology; D011725:Pyridines / Q000494:pharmacology; D011994:Recombinant Proteins / Q000138:chemical synthesis / Q000235:genetics / Q000494:pharmacology; D000077157:Sorafenib; D053221:TNF-Related Apoptosis-Inducing Ligand / Q000138:chemical synthesis / Q000235:genetics / Q000494:pharmacology; D000077337:Vorinostat
chemical_list: D001557:Benzenesulfonates; D056572:Histone Deacetylase Inhibitors; D006877:Hydroxamic Acids; D010671:Phenylurea Compounds; D047428:Protein Kinase Inhibitors; D011725:Pyridines; D011994:Recombinant Proteins; D053221:TNF-Related Apoptosis-Inducing Ligand; C505653:TNFSF10 protein, human; D009536:Niacinamide; D000077337:Vorinostat; D000077157:Sorafenib