title: Predictors of quality of life in patients with refractory mesial temporal lobe epilepsy.
abstract: OBJECTIVE
  The identification of variables associated with health-related quality of life (HRQoL) in patients with mesial temporal lobe epilepsy related to hippocampal sclerosis (MTLE-HS) would improve surgical decision-making and post-operatory follow-up in this group of patients.
  
  
  METHODS
  We analyzed the independent association between the Quality of Life in Epilepsy Inventory-31 (QOLIE-31) of 81 consecutive patients with refractory MTLE-HS. The clinical, demographic, radiological and electrophysiological variables were analyzed by multiple linear regression analysis.
  
  
  RESULTS
  Approximately 36% (adjusted R(2)=0.36; R coefficient=0.66) of the QOLIE-31 overall score variance was explained by the history of initial precipitant injury, family history of epilepsy, disease duration, age of epilepsy onset, seizure frequency and presence of psychiatric axis-II diagnosis. The variance of QOLIE-31 sub-scales was: seizure worry=7%; overall QOL=11%; emotional well-being=32%; energy/fatigue=38%; cognitive function=13%; medication effects=7%; social function=13% (R coefficient between 0.30 and 0.65).
  
  
  CONCLUSIONS
  The pre-surgical variables studied had relatively low prediction capacity for the overall QOLIE-31 score and its sub-scales in this set of Brazilian patients with refractory MTLE-HS.
authors.affiliation: Centro de Epilepsia de Santa Catarina, Hospital Governador Celso Ramos, Florianópolis, SC, Brazil.
authors.forename: Carla
authors.initials: C
authors.lastname: Pauli
authors.forename: Maria Emilia de Oliveira
authors.initials: ME
authors.lastname: Thais
authors.forename: Lucia Sukys
authors.initials: LS
authors.lastname: Claudino
authors.forename: Maria Alice Horta
authors.initials: MA
authors.lastname: Bicalho
authors.forename: Alexandre Cunha
authors.initials: AC
authors.lastname: Bastos
authors.forename: Ricardo
authors.initials: R
authors.lastname: Guarnieri
authors.forename: Jean Costa
authors.initials: JC
authors.lastname: Nunes
authors.forename: Katia
authors.initials: K
authors.lastname: Lin
authors.forename: Marcelo Neves
authors.initials: MN
authors.lastname: Linhares
authors.forename: Roger
authors.initials: R
authors.lastname: Walz
mesh_terms: D000328:Adult; D004833:Epilepsy, Temporal Lobe / Q000473:pathology / Q000523:psychology* / Q000601:surgery; D005260:Female; D006304:Health Status; D006624:Hippocampus / Q000473:pathology* / Q000601:surgery; D006801:Humans; D008297:Male; D011788:Quality of Life / Q000523:psychology*; D012598:Sclerosis; D012720:Severity of Illness Index; D011795:Surveys and Questionnaires; D016896:Treatment Outcome