title: Assessment of the plasma/serum IgG test to screen for periodontitis.
abstract: Chronic periodontitis is a silent infectious disease prevalent worldwide and affects lifestyle-related diseases. Therefore, efficient screening of patients is essential for general health. This study was performed to evaluate prospectively the diagnostic utility of a blood IgG antibody titer test against periodontal pathogens. Oral examination was performed, and IgG titers against periodontal pathogens were measured by ELISA in 1,387 individuals. The cut-off value of the IgG titer was determined in receiver operating characteristic curve analysis, and changes in periodontal clinical parameters and IgG titers by periodontal treatment were evaluated. The relationships between IgG titers and severity of periodontitis were analyzed. The best cut-off value of IgG titer against Porphyromonas gingivalis for screening periodontitis was 1.682. Both clinical parameters and IgG titers decreased significantly under periodontal treatment. IgG titers of periodontitis patients were significantly higher than those of healthy controls, especially in those with sites of probing pocket depth over 4 mm. Multiplied cut-off values were useful to select patients with severe periodontitis. A blood IgG antibody titer test for Porphyromonas gingivalis is useful to screen hitherto chronic periodontitis patients.
authors.affiliation: Department of Periodontics and Endodontics, Okayama University Hospital, Okayama, Japan.
authors.forename: C
authors.initials: C
authors.lastname: Kudo
authors.forename: K
authors.initials: K
authors.lastname: Naruishi
authors.forename: H
authors.initials: H
authors.lastname: Maeda
authors.forename: Y
authors.initials: Y
authors.lastname: Abiko
authors.forename: T
authors.initials: T
authors.lastname: Hino
authors.forename: M
authors.initials: M
authors.lastname: Iwata
authors.forename: C
authors.initials: C
authors.lastname: Mitsuhashi
authors.forename: S
authors.initials: S
authors.lastname: Murakami
authors.forename: T
authors.initials: T
authors.lastname: Nagasawa
authors.forename: T
authors.initials: T
authors.lastname: Nagata
authors.forename: S
authors.initials: S
authors.lastname: Yoneda
authors.forename: Y
authors.initials: Y
authors.lastname: Nomura
authors.forename: T
authors.initials: T
authors.lastname: Noguchi
authors.forename: Y
authors.initials: Y
authors.lastname: Numabe
authors.forename: Y
authors.initials: Y
authors.lastname: Ogata
authors.forename: T
authors.initials: T
authors.lastname: Sato
authors.forename: H
authors.initials: H
authors.lastname: Shimauchi
authors.forename: K
authors.initials: K
authors.lastname: Yamazaki
authors.forename: A
authors.initials: A
authors.lastname: Yoshimura
authors.forename: S
authors.initials: S
authors.lastname: Takashiba
mesh_terms: D000328:Adult; D016976:Aggregatibacter actinomycetemcomitans / Q000276:immunology; D000907:Antibodies, Bacterial / Q000097:blood; D016022:Case-Control Studies; D055113:Chronic Periodontitis / Q000097:blood / Q000175:diagnosis* / Q000276:immunology / Q000382:microbiology; D016124:Eikenella corrodens / Q000276:immunology; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood; D008297:Male; D008403:Mass Screening / Q000379:methods*; D008875:Middle Aged; D016966:Porphyromonas gingivalis / Q000276:immunology*; D018713:Prevotella intermedia / Q000276:immunology; D011446:Prospective Studies; D012372:ROC Curve; D012016:Reference Values; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity
chemical_list: D000907:Antibodies, Bacterial; D007074:Immunoglobulin G