title: Amebic liver abscess diagnosed by polymerase chain reaction in 14 returning travelers.
abstract: Amebic liver abscesses (ALA) are not commonly described in travelers. The ALA diagnosis is usually based on serology and Entamoeba histolytica polymerase chain reaction (PCR) is a new tool. We retrospectively reviewed all ALA cases diagnosed by PCR on the liver abscess pus aspirate of patients admitted in 4 teaching hospitals in Paris, France between 2007 and 2011. Fourteen cases (10 male, median age 48 years) were included. The median lag time between return and onset of symptoms was 23 days among 10 patients (interquartile range [IQ] 18–24) whereas the remaining patients had travelled over 2 years ago.All patients had an elevated C-reactive protein level, and 11 had leukocytosis. The ALA was multiple in five patients, localized in the right lobe in 12, and higher than 5 cm in 11. Serology was initially negative in one patient, whereas PCR was positive. There was bacterial co-infection in one patient. The outcome was good. Liver puncture allows a rapid diagnosis of ALA with PCR and helps identify the association with a bacterial dual infection [corrected]..
authors.affiliation: Infectious and Tropical Diseases Department, Groupe Hospitalier Pitié-Salpêtrière, Paris, France.
authors.forename: Dorothée
authors.initials: D
authors.lastname: Vallois
authors.forename: Loïc
authors.initials: L
authors.lastname: Epelboin
authors.forename: Feriel
authors.initials: F
authors.lastname: Touafek
authors.forename: Denis
authors.initials: D
authors.lastname: Magne
authors.forename: Marc
authors.initials: M
authors.lastname: Thellier
authors.forename: François
authors.initials: F
authors.lastname: Bricaire
authors.forename: Eric
authors.initials: E
authors.lastname: Caumes
mesh_terms: D000328:Adult; D000890:Anti-Infective Agents / Q000627:therapeutic use; D005260:Female; D005602:France; D006801:Humans; D008101:Liver Abscess, Amebic / Q000175:diagnosis* / Q000188:drug therapy / Q000453:epidemiology; D008297:Male; D008795:Metronidazole / Q000627:therapeutic use; D008875:Middle Aged; D012189:Retrospective Studies
chemical_list: D000890:Anti-Infective Agents; D008795:Metronidazole