title: Advances and strategies in discovery of new antibacterials for combating metabolically resting bacteria.
abstract: Discovery of new antibacterial agents is crucial to counter the challenge of drug-resistant bacterial infections. In this review we discuss the issue of bacterial metabolic resting states, observed for a variety of pathogenic bacteria, which display low susceptibility for most antibacterials. We present examples of how bacterial metabolic states may be controlled, target pathways may be validated and screening on metabolically resting bacteria can be designed. A deeper understanding of bacterial metabolic states may provide valuable input for the design of efficient screening approaches in the discovery of new antibacterial agents.
authors.affiliation: Department of Molecular Cell Biology, Faculty of Earth- and Life Sciences, VU University Amsterdam, De Boelelaan 1085, 1081 HV Amsterdam, The Netherlands. dirk.bald@falw.vu.nl
authors.forename: Dirk
authors.initials: D
authors.lastname: Bald
authors.forename: Anil
authors.initials: A
authors.lastname: Koul
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects* / Q000378:metabolism; D055808:Drug Discovery
chemical_list: D000900:Anti-Bacterial Agents