title: Nucleosome assembly proteins and their interacting proteins in neuronal differentiation.
abstract: Neuronal differentiation from neural stem cells into mature neurons is guided by the concerted action of specific transcription factors that stepwise exercise their role in the context of defined chromatin states. Amongst the classes of proteins that influence chromatin compaction and modification are nucleosome assembly proteins (NAPs). Mammals possess several nucleosome assembly protein 1 like proteins (NAP1L) that show either ubiquitous or neuron-restricted expression. The latter group is presumably involved in the process of neuronal differentiation. Mammalian NAP1Ls can potentially form both homo- and hetero-dimers and octamers, in theory allowing thousands of different combinations to be formed. Detailed studies have been performed on several of the NAP1Ls that point to a range of molecular roles, including transcriptional regulation, nuclear import, and control of cell division. This article aims at summarizing current knowledge of the mammalian NAP1L family and its interactions.
authors.affiliation: Institut Pasteur, Unité de Génétique Moléculaire Murine, CNRS URA 2578, 25 rue du Docteur Roux, 75724 Paris Cedex 15, France. mikael.attia@curie.fr
authors.forename: Mikaël
authors.initials: M
authors.lastname: Attia
authors.forename: Christophe
authors.initials: C
authors.lastname: Rachez
authors.forename: Philip
authors.initials: P
authors.lastname: Avner
authors.forename: Ute Christine
authors.initials: UC
authors.lastname: Rogner
mesh_terms: D021581:Active Transport, Cell Nucleus; D000818:Animals; D002467:Cell Nucleus / Q000235:genetics / Q000378:metabolism; D042002:Chromatin Assembly and Disassembly; D005786:Gene Expression Regulation; D006801:Humans; D008322:Mammals / Q000235:genetics / Q000378:metabolism; D055495:Neurogenesis; D009474:Neurons / Q000166:cytology* / Q000378:metabolism; D056490:Nucleosome Assembly Protein 1 / Q000235:genetics / Q000378:metabolism*; D009707:Nucleosomes / Q000235:genetics / Q000378:metabolism*; D011485:Protein Binding; D025941:Protein Interaction Mapping / Q000379:methods; D014158:Transcription, Genetic
chemical_list: D056490:Nucleosome Assembly Protein 1; D009707:Nucleosomes