title: A fiber optic probe design to measure depth-limited optical properties in-vivo with low-coherence enhanced backscattering (LEBS) spectroscopy.
abstract: Low-coherence enhanced backscattering (LEBS) spectroscopy is an angular resolved backscattering technique that is sensitive to sub-diffusion light transport length scales in which information about scattering phase function is preserved. Our group has shown the ability to measure the spatial backscattering impulse response function along with depth-selective optical properties in tissue ex-vivo using LEBS. Here we report the design and implementation of a lens-free fiber optic LEBS probe capable of providing depth-limited measurements of the reduced scattering coefficient in-vivo. Experimental measurements combined with Monte Carlo simulation of scattering phantoms consisting of polystyrene microspheres in water are used to validate the performance of the probe. Additionally, depth-limited capabilities are demonstrated using Monte Carlo modeling and experimental measurements from a two-layered phantom.
authors.affiliation: Department of Biomedical Engineering, Northwestern University, 2145 Sheridan Road, Evanston, IL 60208, USA.
authors.forename: Nikhil N
authors.initials: NN
authors.lastname: Mutyal
authors.forename: Andrew
authors.initials: A
authors.lastname: Radosevich
authors.forename: Bradley
authors.initials: B
authors.lastname: Gould
authors.forename: Jeremy D
authors.initials: JD
authors.lastname: Rogers
authors.forename: Andrew
authors.initials: A
authors.lastname: Gomes
authors.forename: Vladimir
authors.initials: V
authors.lastname: Turzhitsky
authors.forename: Vadim
authors.initials: V
authors.lastname: Backman
mesh_terms: D017076:Computer-Aided Design; D004867:Equipment Design; D019544:Equipment Failure Analysis; D005336:Fiber Optic Technology / Q000295:instrumentation*; D009391:Nephelometry and Turbidimetry / Q000295:instrumentation*; D010783:Photometry / Q000295:instrumentation*; D013057:Spectrum Analysis / Q000295:instrumentation*; D014159:Transducers