title: A tetradentate ligand for the enantioselective Ti(IV)-promoted oxidation of sulfides to sulfoxides: origin of enantioselectivity.
abstract: A detailed stereomechanistic analysis has led to the design of a new tetradentate ligand for the enantioselective Ti(IV)-catalyzed oxidation of unsymmetrical sulfides to sulfoxides with high selectivity. The pathway of this oxidation and the closely related and long-known Kagan-Modena oxidation have been clarified to identify the likely origin of the enantioselectivity.
authors.affiliation: Department of Chemistry and Chemical Biology, Harvard University, Cambridge, Massachusetts 02138, USA.
authors.forename: Timothy R
authors.initials: TR
authors.lastname: Newhouse
authors.forename: Xin
authors.initials: X
authors.lastname: Li
authors.forename: Megan M
authors.initials: MM
authors.lastname: Blewett
authors.forename: Clare M C
authors.initials: CM
authors.lastname: Whitehead
authors.forename: E J
authors.initials: EJ
authors.lastname: Corey
mesh_terms: D002384:Catalysis; D008024:Ligands; D015394:Molecular Structure; D010084:Oxidation-Reduction; D011789:Quantum Theory; D013237:Stereoisomerism; D013440:Sulfides / Q000737:chemistry*; D013454:Sulfoxides / Q000138:chemical synthesis* / Q000737:chemistry; D014025:Titanium / Q000737:chemistry*
chemical_list: D008024:Ligands; D013440:Sulfides; D013454:Sulfoxides; D014025:Titanium