title: Effective properties of a sturgeon-based bioactive compound on stress-induced hippocampal degeneration and on in vitro neurogenesis.
abstract: The aim of this study is to test the activity of a marine bioactive compound containing high-purity caviar-derived DNA, collagen elastin and protein extracts from sturgeon (LD-1227, Caviarlieri, Laboratoires Dom, Switzerland) to exert neuroprotective properties in an experimental setting while also being potential triggers of neurogenesis in a separate in vitro study. Supplementation with high-DHA mixture of LD-1227 was applied for 30 days to stress model rats. Both supplementations significantly mitigated the histological brain damage when analyzing hippocampal subregions and corticosterone level. However, LD-1227 was most significantly efficient in preventing SOD, Catalase and ascorbic acid decrease in brain tissue. Both supplementations stimulated neurogenesis in vitro and neuron markers in particular but og olygodendrocyte markers and glia increased only in LD-1227-enriched medium. Taken together, these data suggest that LD-1227 is able to significantly protect the brain structure redox system to higher degree than DHA. Moreover, from in vitro study it appears that marine bioactive compound, through it wide array of small unsaturated fatty acids, phospholipids and neurotransmitter precursors, is likely to influence neuronal and glial lineage to act differently from a DHA-rich mixture.
authors.affiliation: ReGenera Research Group for Aging-Intervention, Milano, Italy. fmarchimede@libero.it
authors.forename: F
authors.initials: F
authors.lastname: Marotta
authors.forename: D H
authors.initials: DH
authors.lastname: Chui
authors.forename: H
authors.initials: H
authors.lastname: Yadav
authors.forename: A
authors.initials: A
authors.lastname: Lorenzetti
authors.forename: G
authors.initials: G
authors.lastname: Celep
authors.forename: S
authors.initials: S
authors.lastname: Jain
authors.forename: A
authors.initials: A
authors.lastname: Bomba
authors.forename: A
authors.initials: A
authors.lastname: Polimeni
authors.forename: K
authors.initials: K
authors.lastname: Zhong
authors.forename: F
authors.initials: F
authors.lastname: Allegri
mesh_terms: D000818:Animals; D000943:Antigens, Differentiation / Q000378:metabolism; D002478:Cells, Cultured; D045424:Complex Mixtures / Q000737:chemistry / Q000494:pharmacology*; D029941:Fish Proteins / Q000737:chemistry / Q000494:pharmacology*; D005399:Fishes; D006624:Hippocampus / Q000378:metabolism* / Q000473:pathology; D019636:Neurodegenerative Diseases / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology; D055495:Neurogenesis / Q000187:drug effects*; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D000943:Antigens, Differentiation; D045424:Complex Mixtures; D029941:Fish Proteins