title: Effect of glucosamine and chitooligomer on the toxicity of arsenite against Escherichia coli.
abstract: Escherichia coli was selected as the sample to study the toxicity of arsenite in the presence of saccharides. The effect of glucosamine, N-acetylglucosamine, glucose, lactose, sucrose, glucosamine and cyclodextrin on the toxicity of arsenite against E. coli was investigated by microcalorimetry. The glucosamine and the tested chitooligomer decreased the toxicity of arsenite on cells of E. coli, and the effect of glucosamine was stronger than that of the chitooligomer. These results suggest that the glucosamine and chitooligomer may be employed as the assistant antidote for arsenite.
authors.affiliation: Hubei Key Laboratory of Biomass-Resource Chemistry and Environmental Biotechnology, Hubei Engineering University, Xiaogan 432000, China.
authors.forename: Meifang
authors.initials: M
authors.lastname: Fu
authors.forename: Caiqin
authors.initials: C
authors.lastname: Qin
authors.forename: Wei
authors.initials: W
authors.lastname: Li
authors.forename: Yongbin
authors.initials: Y
authors.lastname: Yan
authors.forename: Lintao
authors.initials: L
authors.lastname: Zeng
authors.forename: Xinhe
authors.initials: X
authors.lastname: Yang
mesh_terms: D000931:Antidotes / Q000494:pharmacology*; D018053:Arsenites / Q000037:antagonists & inhibitors* / Q000633:toxicity*; D048271:Chitosan / Q000737:chemistry* / Q000494:pharmacology*; D004926:Escherichia coli / Q000187:drug effects*; D005944:Glucosamine / Q000494:pharmacology*
chemical_list: D000931:Antidotes; D018053:Arsenites; D048271:Chitosan; D005944:Glucosamine; C015001:arsenite