title: [The revised Gell and Coombs classification: a new reading of old truths in the context of immunodeficiencies theory].
abstract: The publication covers the world-known Gell and Coombs classification of immunopathological reactions, last revised, in the context of immunodeficiencies theory. A great attention is paid to the description of protective immune reactions, allergic and autoimmune complications, being developed according to one or another mechanism, defined in the classification. The strong and weak points of the classification were marked and the promising trends to carry out further scientific enquiry were emphasized. Primary immunodeficiencies were considered in detail as natural models of immunopathological complications. The problems of immunodiagnosis and immunotherapy were discussed.
authors.forename: D V
authors.initials: DV
authors.lastname: Mal'tsev
authors.forename: V E
authors.initials: VE
authors.lastname: Kazmirchuk
authors.forename: V V
authors.initials: VV
authors.lastname: Tsarik
mesh_terms: D056704:Adaptive Immunity; D003298:Coombs Test; D016207:Cytokines / Q000096:biosynthesis / Q000276:immunology; D006801:Humans; D006967:Hypersensitivity / Q000145:classification* / Q000175:diagnosis / Q000276:immunology / Q000503:physiopathology; D007136:Immunoglobulins / Q000096:biosynthesis / Q000276:immunology; D007153:Immunologic Deficiency Syndromes / Q000145:classification* / Q000175:diagnosis / Q000503:physiopathology; D013601:T-Lymphocytes / Q000276:immunology
chemical_list: D016207:Cytokines; D007136:Immunoglobulins