title: A novel combined imaging/morphometrical method for the analysis of human sural nerve biopsies for clinical diagnosis.
abstract: Nerve Morphometry is one tool employed in the clinical assessment of peripheral sural nerve pathological abnormalities. A new method is presented in this chapter incorporating an unbiased approach to quantitative sural nerve evaluation. Using conventional epoxy embedded nerves processed for electron microscopy, confocal microscopy, and interactive digital assessment, this method produces a rigorous, accurate reproducible record for use in clinical diagnosis.
authors.affiliation: Department of Pathology and Microscopy Imaging Center, College of Medicine, University of Vermont, Burlington, VT, USA.
authors.forename: Michele A
authors.initials: MA
authors.lastname: Vonturkovich
authors.forename: Marilyn P
authors.initials: MP
authors.lastname: Wadsworth
authors.forename: William W
authors.initials: WW
authors.lastname: Pendlebury
authors.forename: Douglas J
authors.initials: DJ
authors.lastname: Taatjes
mesh_terms: D001706:Biopsy; D016616:Cryoultramicrotomy; D004210:Dissection; D006801:Humans; D007091:Image Processing, Computer-Assisted; D018613:Microscopy, Confocal; D008854:Microscopy, Electron; D010523:Peripheral Nervous System Diseases / Q000175:diagnosis / Q000473:pathology; D012984:Software; D013194:Staining and Labeling; D013497:Sural Nerve / Q000473:pathology*; D016707:Tissue Fixation / Q000379:methods