title: Coupling of active motion and advection shapes intracellular cargo transport.
abstract: Intracellular cargo transport can arise from passive diffusion, active motor-driven transport along cytoskeletal filament networks, and passive advection by fluid flows entrained by such cargo-motor motion. Active and advective transport are thus intrinsically coupled as related, yet different representations of the same underlying network structure. A reaction-advection-diffusion system is used here to show that this coupling affects the transport and localization of a passive tracer in a confined geometry. For sufficiently low diffusion, cargo localization to a target zone is optimized either by low reaction kinetics and decoupling of bound and unbound states, or by a mostly disordered cytoskeletal network with only weak directional bias. These generic results may help to rationalize subtle features of cytoskeletal networks, for example as observed for microtubules in fly oocytes.
authors.affiliation: Department of Applied Mathematics and Theoretical Physics, University of Cambridge, Wilberforce Road, Cambridge CB3 0WA, United Kingdom.
authors.forename: Philipp
authors.initials: P
authors.lastname: Khuc Trong
authors.forename: Jochen
authors.initials: J
authors.lastname: Guck
authors.forename: Raymond E
authors.initials: RE
authors.lastname: Goldstein
mesh_terms: D000818:Animals; D001692:Biological Transport; D001693:Biological Transport, Active; D003593:Cytoplasm / Q000378:metabolism*; D003599:Cytoskeleton / Q000378:metabolism*; D004058:Diffusion; D008954:Models, Biological; D020409:Molecular Motor Proteins / Q000378:metabolism; D015388:Organelles / Q000378:metabolism*
chemical_list: D020409:Molecular Motor Proteins