title: Zebrafish: an animal model for toxicological studies.
abstract: Zebrafish (Danio rerio) has been extensively studied and well described for environmental toxicity studies. Molecular biology and genetics have recently been used to elucidate the underlying mechanisms of toxicity in zebrafish and to predict effects in mammals. The versatile zebrafish is now incorporated in many areas of toxicological programs for assessing human risk and for preclinical drug discovery and screening.
authors.affiliation: Phylonix Pharmaceuticals, Cambridge, MA, USA.
authors.forename: Chaojie
authors.initials: C
authors.lastname: Zhang
authors.forename: Catherine
authors.initials: C
authors.lastname: Willett
authors.forename: Trisha
authors.initials: T
authors.lastname: Fremgen
mesh_terms: D023401:Animal Use Alternatives / Q000379:methods*; D000818:Animals; D064420:Drug-Related Side Effects and Adverse Reactions; D054750:Ecotoxicology / Q000379:methods; D004625:Embryo, Nonmammalian / Q000187:drug effects; D047108:Embryonic Development / Q000187:drug effects; D052244:Endocrine Disruptors / Q000633:toxicity; D009153:Mutagens / Q000633:toxicity; D009928:Organ Specificity; D013723:Teratogens / Q000633:toxicity; D014116:Toxicology / Q000379:methods*; D015027:Zebrafish / Q000196:embryology / Q000235:genetics
chemical_list: D052244:Endocrine Disruptors; D009153:Mutagens; D013723:Teratogens