title: Effects of 2 different medetomidine infusion rates on selected neurohormonal and metabolic parameters in dogs.
abstract: The effects of 2 different 8-hour continuous rate infusions (CRIs) of medetomidine on epinephrine, norepinephrine, cortisol, glucose, and insulin levels were investigated in 6 healthy dogs. Each dog received both treatments and a control as follows: MED1 = 2 μg/kg bodyweight (BW) loading dose followed by 1 μg/kg BW per hour CRI; MED2 = 4 μg/kg BW loading dose followed by 2 μg/kg BW per hour CRI; and CONTROL = saline bolus followed by a saline CRI. Both infusion rates of medetomidine decreased norepinephrine levels throughout the infusion compared to CONTROL. While norepinephrine levels tended to be lower with the MED2 treatment compared to the MED1, this difference was not significant. No differences in epinephrine, cortisol, glucose, or insulin were documented among any of the treatments at any time point. At the low doses used in this study, both CRIs of medetomidine decreased norepinephrine levels over the 8-hour infusion period, while no effects were observed on epinephrine, cortisol, glucose, and insulin.
authors.affiliation: Department of Companion Animals, University of Prince Edward Island, Charlottetown, Prince Edward Island C1A 4P3.
authors.forename: Leigh
authors.initials: L
authors.lastname: Lamont
authors.forename: Shelley
authors.initials: S
authors.lastname: Burton
authors.forename: Deanne
authors.initials: D
authors.lastname: Caines
authors.forename: Elmabrok
authors.initials: E
authors.lastname: Masaoud
authors.forename: Eric
authors.initials: E
authors.lastname: Troncy
mesh_terms: D058647:Adrenergic alpha-2 Receptor Agonists / Q000008:administration & dosage*; D000818:Animals; D019540:Area Under Curve; D001786:Blood Glucose / Q000378:metabolism; D004285:Dogs / Q000097:blood / Q000378:metabolism*; D004837:Epinephrine / Q000097:blood; D005260:Female; D006854:Hydrocortisone / Q000097:blood; D007262:Infusions, Intravenous / Q000662:veterinary; D007328:Insulin / Q000097:blood; D008297:Male; D020926:Medetomidine / Q000008:administration & dosage*; D009638:Norepinephrine / Q000097:blood; D011897:Random Allocation
chemical_list: D058647:Adrenergic alpha-2 Receptor Agonists; D001786:Blood Glucose; D007328:Insulin; D020926:Medetomidine; D006854:Hydrocortisone; D009638:Norepinephrine; D004837:Epinephrine