title: Fluoride and silver concentrations of silver diammine fluoride solutions for dental use.
abstract: OBJECTIVE
  To determine the short-term stability of free fluoride ion concentrations and acidity (pH values) of three commercially available SDF solutions over time.
  
  
  METHODS
  Three SDF products for caries control were studied: Cariestop-12%, Cariestop-30% and Saforide-38%. Their expected fluoride ion concentrations were 14,200, 35,400 and 44,800 ppm, respectively. The fluoride ion concentrations were determined with an ion-selective electrode. The acidity was determined with a pH electrode. The measurements were performed when open and at 7 and 28 days.
  
  
  RESULTS
  The mean fluoride ion concentrations of the freshly opened bottles were 12,525 ± 450, 13,200 ± 2060 and 55,800 ± 2536 ppm, respectively. The mean pH values were 9.4 ± 0.1, 10.4 ± 0.1 and 10.2 ± 0.2, respectively. No significant change (P > 0.05) in the fluoride ion concentrations or the acidity was detected after 7 or 28 days.
  
  
  CONCLUSIONS
  The three SDF tested solutions were alkaline. The fluoride ion concentrations of Cariestop-30% and Saforide-38% were considerably different. The fluoride ion concentrations and acidity of the products demonstrated a short-term stability over 28 days.
authors.affiliation: Faculty of Dentistry, The University of Hong Kong, Sai Ying Pun, Hong Kong.
authors.forename: May Lei
authors.initials: ML
authors.lastname: Mei
authors.forename: Chun Hung
authors.initials: CH
authors.lastname: Chu
authors.forename: Edward Chin Man
authors.initials: EC
authors.lastname: Lo
authors.forename: Lakshman Perera
authors.initials: LP
authors.lastname: Samaranayake
mesh_terms: D002327:Cariostatic Agents / Q000737:chemistry*; D004355:Drug Stability; D005459:Fluorides / Q000032:analysis*; D005460:Fluorides, Topical; D006801:Humans; D006863:Hydrogen-Ion Concentration; D017736:Ion-Selective Electrodes; D008422:Materials Testing; D000644:Quaternary Ammonium Compounds / Q000737:chemistry*; D012834:Silver / Q000032:analysis*; D018030:Silver Compounds; D013997:Time Factors
chemical_list: D002327:Cariostatic Agents; D005460:Fluorides, Topical; D000644:Quaternary Ammonium Compounds; D018030:Silver Compounds; D012834:Silver; C024633:silver diamine fluoride; D005459:Fluorides