title: Similar prevalence, different spectrum: IgE-mediated food allergy among Turkish adolescents.
abstract: BACKGROUND
  Scarcity of reliable data on food allergy prevalence exists in Turkey. We aimed to assess reported and confirmed IgE-mediated food allergy prevalence, and define the spectrum of allergenic food.
  
  
  METHODS
  We prospectively evaluated the ISAAC Phase II study population for food allergy. Participants that reported experiencing food allergy symptom in the last year and/or were skin prick test positive for a predefined list of food allergens, were interviewed via telephone, and those considered as having food allergy were invited to undergo clinical investigation, including challenge tests.
  
  
  RESULTS
  A total of 6963 questionnaires were available. Parental reported food allergy prevalence and skin prick sensitisation rate were 20.2 ± 0.9% and 5.9 ± 0.6%. According to the above-defined criteria, 1162 children (symptom positive n=909, skin prick test positive n=301, both positive n=48) were selected and 813 (70.0%) were interviewed via telephone. Out of 152 adolescents reporting a current complaint, 87 accepted clinical investigation. There were 12 food allergies diagnosed in nine adolescents, with food allergy prevalence of 0.16 ± 0.11%. The most common foods involved in allergic reactions were walnut (n=3) and beef meat (n=2), followed by hen's egg (n=1), peanut (n=1), spinach (n=1), kiwi (n=1), cheese (n=1), hazelnut (n=1) and peach (n=1).
  
  
  CONCLUSIONS
  While parental reported food allergy prevalence was within the range reported previously, confirmed IgE-mediated food allergy prevalence among adolescents was at least 0.16%, and the spectrum of foods involved in allergy differed from Western countries, implying environmental factors may play a role.
authors.affiliation: Hacettepe University, Faculty of Medicine, Pediatric Allergy and Asthma Unit, Ankara, Turkey.
authors.forename: R
authors.initials: R
authors.lastname: Mustafayev
authors.forename: E
authors.initials: E
authors.lastname: Civelek
authors.forename: F
authors.initials: F
authors.lastname: Orhan
authors.forename: H
authors.initials: H
authors.lastname: Yüksel
authors.forename: A B
authors.initials: AB
authors.lastname: Boz
authors.forename: B E
authors.initials: BE
authors.lastname: Sekerel
mesh_terms: D000293:Adolescent; D000485:Allergens / Q000276:immunology; D000818:Animals; D002417:Cattle; D002648:Child; D000939:Epitopes; D005260:Female; D005512:Food Hypersensitivity / Q000453:epidemiology* / Q000276:immunology*; D006801:Humans; D007073:Immunoglobulin E / Q000097:blood / Q000276:immunology*; D031324:Juglans / Q000276:immunology; D008297:Male; D008460:Meat / Q000009:adverse effects; D015995:Prevalence; D011446:Prospective Studies; D012882:Skin Tests; D011795:Surveys and Questionnaires; D014421:Turkey / Q000453:epidemiology
chemical_list: D000485:Allergens; D000939:Epitopes; D007073:Immunoglobulin E