title: The influence of toxic working environment on the urothelial bladder tumors characteristics, the experience of "Sf. Ioan" Clinical Emergency Hospital on selected series.
abstract: BACKGROUND
  A correlation between urothelial bladder tumor incidence and exposure to various occupational toxic factors was established for more than a century. The aim of our study was to establish the relationship between these two features.
  
  
  METHODS
  We analyzed one hundred consecutive bladder tumor patients treated in "Sf. Ioan" Clinical Emergency Hospital, Department of Urology. These cases were studied concerning their occupation and pathological findings.
  
  
  RESULTS
  We identified 58 patients having potential urothelial bladder tumors inducing occupations: dye industry, motor vehicle drivers and miners. Among these patients, the incidence of muscle invasive tumors was of 33%, of the high-grade tumors was of 69%, of the multiple tumors was of 60% and of the associated CIS lesions was of 38%. All these rates were significantly lower in the non-occupational hazard group: 12%, 26%, 29% and 14% respectively.
  
  
  CONCLUSIONS
  Exposure to occupational toxic factors seems to influence the evolution of urothelial bladder tumor into more aggressive patterns. Further studies in this regard are necessary.
authors.affiliation: Sf. Ioan Clinical Emergency Hospital, Department of Urology, Bucharest, Romania.
authors.forename: M
authors.initials: M
authors.lastname: Drăguţescu
authors.forename: B
authors.initials: B
authors.lastname: Geavlete
authors.forename: R
authors.initials: R
authors.lastname: Mulţescu
authors.forename: B
authors.initials: B
authors.lastname: Mihai
authors.forename: C
authors.initials: C
authors.lastname: Moldoveanu
authors.forename: P
authors.initials: P
authors.lastname: Geavlete
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D004636:Emergency Service, Hospital / Q000706:statistics & numerical data*; D005260:Female; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D016273:Occupational Exposure; D012383:Romania / Q000453:epidemiology; D001749:Urinary Bladder Neoplasms / Q000453:epidemiology* / Q000473:pathology; D019459:Urothelium / Q000473:pathology*