title: Axillary reverse mapping (ARM): initial results of phase II trial in preventing lymphedema after lymphadenectomy.
abstract: BACKGROUND
  Axillary reverse mapping (ARM) is unproven in preventing lymphedema. The purpose of this study is to evaluate lymphedema rates with ARM added to lymphadenectomy.
  
  
  METHODS
  In this IRB approved study, 156 cases of SLNB/ALND from May 2007 to March 2010 were prospectively accrued to the study. Patients with an increase in arm volume greater than 20% over the contralateral side were considered to have lymphedema. Data was collected on identification and variations in lymphatic drainage, nodal status, ARM lymphatics preservation rate, adjuvant treatment (XRT, chemo) and lymphedema rate.
  
  
  RESULTS
  114 patients underwent SLNB only and 42 patients underwent ALND after SLNB, with a SLN identification rate of 100%. Median age was 56.9(±12.5) and BMI was 29.4(±6.9). Mean follow up was 14.6±9.4 months. ARM lymphatics were near or in the SLN field in 45/114 (39%) of the SLNB cases and in 34/42 (81%) of the ALND. ARM nodes were preserved in 92.3% of the cases (144/156). A total of 12 ARM nodes were resected because of crossover or suspicious appearance. The 2 ARM nodes involved by malignancy were in heavily positive axilla (>5 positive nodes). Lymphedema was diagnosed in 3.5% (4/114) of the SLNB cases and 7%(3/42) of the combined SLNB+ALND cases. 2.9% (4/140) of the patients who had the ARM lymphatics preserved and 18.7%(3/16) who had it transected developed clinical lymphedema. No regional recurrences were seen.
  
  
  CONCLUSIONS
  Preserving the ARM nodes is safe and resulted in a low incidence of postoperative lymphedema after SLNB and ALND.
authors.affiliation: University of Arkansas for Medical Sciences, Little Rock, AR, USA. boneticristiano@uams.edu
authors.forename: C
authors.initials: C
authors.lastname: Boneti
authors.forename: B
authors.initials: B
authors.lastname: Badgwell
authors.forename: Y
authors.initials: Y
authors.lastname: Robertson
authors.forename: S
authors.initials: S
authors.lastname: Korourian
authors.forename: L
authors.initials: L
authors.lastname: Adkins
authors.forename: V
authors.initials: V
authors.lastname: Klimberg
mesh_terms: D001365:Axilla; D001943:Breast Neoplasms / Q000473:pathology* / Q000601:surgery*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008197:Lymph Node Excision / Q000009:adverse effects* / Q000379:methods*; D008209:Lymphedema / Q000209:etiology / Q000473:pathology* / Q000517:prevention & control*; D008875:Middle Aged; D011446:Prospective Studies