title: Mitochondrial morphology-emerging role in bioenergetics.
abstract: Dynamic change in mitochondrial shape is a cellular process mediated mainly by fission and fusion of mitochondria. Studies have shown that mitochondrial fission and fusion are directly and indirectly associated with mitochondrial maintenance, bioenergetic demand, and cell death. Changes in mitochondrial morphology are frequently observed in response to changes in the surrounding cellular milieu, such as metabolic flux, that influence cellular bioenergetics. Connections between morphological regulation and the bioenergetic status of mitochondria are emerging as reciprocally responsive processes, though the nature of the signaling remains to be defined. Given the pivotal role mitochondria play in cellular fate, tight regulation of fission and fusion is therefore critical to preserving normal cellular physiology. Here we describe recent advancements in the understanding of the mechanisms governing mitochondrial morphology and their emerging role in mitochondrial bioenergetics.
authors.affiliation: Department of Anesthesiology, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA.
authors.forename: Chad A
authors.initials: CA
authors.lastname: Galloway
authors.affiliation: Department of Physiology, Georgia Health Sciences University, Augusta, GA 30912, USA.
authors.forename: Hakjoo
authors.initials: H
authors.lastname: Lee
authors.affiliation: Department of Physiology, Georgia Health Sciences University, Augusta, GA 30912, USA. Electronic address: yyoon@georgiahealth.edu.
authors.forename: Yisang
authors.initials: Y
authors.lastname: Yoon
mesh_terms: D000818:Animals; D034281:Dynamins; D004734:Energy Metabolism; D020558:GTP Phosphohydrolases / Q000235:genetics / Q000378:metabolism; D006801:Humans; D008869:Microtubule-Associated Proteins / Q000235:genetics / Q000378:metabolism; D008928:Mitochondria / Q000502:physiology* / Q000648:ultrastructure; D063154:Mitochondrial Dynamics; D051336:Mitochondrial Membranes / Q000378:metabolism; D024101:Mitochondrial Proteins / Q000235:genetics / Q000378:metabolism; D053140:Organelle Shape; D017382:Reactive Oxygen Species; D015398:Signal Transduction
chemical_list: D008869:Microtubule-Associated Proteins; D024101:Mitochondrial Proteins; D017382:Reactive Oxygen Species; D020558:GTP Phosphohydrolases; C110768:DNM1L protein, human; D034281:Dynamins