title: Genome-wide association study (GWAS) of resistance to head smut in maize.
abstract: Head smut, caused by the fungus Sphacelotheca reiliana (Kühn) Clint, is a devastating global disease in maize, leading to severe quality and yield loss each year. The present study is the first to conduct a genome-wide association study (GWAS) of head smut resistance using the Illumina MaizeSNP50 array. Out of 45,868 single nucleotide polymorphisms in a panel of 144 inbred lines, 18 novel candidate genes were associated with head smut resistance in maize. These candidate genes were classified into three groups, namely, resistance genes, disease response genes, and other genes with possible plant disease resistance functions. The data suggested a complicated molecular mechanism of maize resistance against S. reiliana. This study also suggested that GWAS is a useful approach for identifying causal genetic factors for head smut resistance in maize.
authors.affiliation: National Key Laboratory of Crop Genetic Improvement, Huazhong Agricultural University, 430070 Wuhan, China.
authors.forename: Ming
authors.initials: M
authors.lastname: Wang
authors.forename: Jianbing
authors.initials: J
authors.lastname: Yan
authors.forename: Jiuran
authors.initials: J
authors.lastname: Zhao
authors.forename: Wei
authors.initials: W
authors.lastname: Song
authors.forename: Xiaobo
authors.initials: X
authors.lastname: Zhang
authors.forename: Yannong
authors.initials: Y
authors.lastname: Xiao
authors.forename: Yonglian
authors.initials: Y
authors.lastname: Zheng
mesh_terms: D000483:Alleles; D001487:Basidiomycota / Q000502:physiology; D002874:Chromosome Mapping; D032461:Chromosomes, Plant / Q000235:genetics; D060467:Disease Resistance / Q000235:genetics; D005787:Gene Frequency; D017343:Genes, Plant / Q000235:genetics*; D018745:Genome, Plant / Q000235:genetics*; D005838:Genotype; D054884:Host-Pathogen Interactions; D015810:Linkage Disequilibrium; D010935:Plant Diseases / Q000235:genetics* / Q000382:microbiology; D020641:Polymorphism, Single Nucleotide; D025341:Principal Component Analysis; D040641:Quantitative Trait Loci / Q000235:genetics; D003313:Zea mays / Q000235:genetics* / Q000382:microbiology