title: A strontium-90 sequestrant for first-aid treatment of radiation emergency.
abstract: In this study, hydrophilic porous polymer beads with phosphonic acid groups (PGMA-EGDMA-TTA-MP) were synthesized, and assessed as a radioactive strontium-90 sequestrant for the treatment of the radiation emergency. Strontium ions were rapidly absorbed into the blood from the gastrointestinal (GI) tract after oral administration to rats, and distributed to the target organ, i.e., bones. Over 40% of the administered strontium was absorbed into the blood, while the remainder was discharged in the feces within 48 h after the administration. When the PGMA-EGDMA-TTA-MP beads were administered to rats subsequent to the strontium solution, the strontium had accumulated less in the femur. Consequently, the oral administration of the PGMA-EGDMA-TTA-MP beads was effective in suppressing the absorption of strontium from the GI tract.
authors.affiliation: Graduate School of Biomedical Sciences, Nagasaki University, 1-14 Bunkyo-machi, Nagasaki 852-8521, Japan. haratake@nagasaki-u.ac.jp
authors.forename: Mamoru
authors.initials: M
authors.lastname: Haratake
authors.forename: Eisuke
authors.initials: E
authors.lastname: Hatanaka
authors.forename: Takeshi
authors.initials: T
authors.lastname: Fuchigami
authors.forename: Makoto
authors.initials: M
authors.lastname: Akashi
authors.forename: Morio
authors.initials: M
authors.lastname: Nakayama
mesh_terms: D000327:Adsorption; D000818:Animals; D004638:Emergency Treatment / Q000379:methods*; D007408:Intestinal Absorption / Q000187:drug effects; D008297:Male; D011108:Polymers / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use*; D016062:Porosity; D011832:Radiation Injuries / Q000188:drug therapy*; D051381:Rats; D017208:Rats, Wistar; D013326:Strontium Radioisotopes / Q000302:isolation & purification* / Q000378:metabolism*
chemical_list: D011108:Polymers; D013326:Strontium Radioisotopes