title: Antibody responses to Hepatitis B and measles-mumps-rubella vaccines in children who received chemotherapy for acute lymphoblastic leukemia.
abstract: OBJECTIVE
  To evaluate viral vaccine antibody levels in children with acute lymphoblastic leukemia after chemotherapy and after vaccine booster doses.
  
  
  METHODS
  Antibody levels against hepatitis B, rubella, measles and mumps vaccine antigens were evaluated in 33 children after completing chemotherapy (before and after vaccine booster doses) and the results were compared to the data of 33 healthy children matched for gender, age and social class.
  
  
  RESULTS
  After chemotherapy, 75.9%, 67.9%, 59.3% and 51.7% of the patients showed low antibody titers that would be unlikely to protect against exposure to measles, rubella, hepatitis B and mumps, respectively. After receiving a vaccine booster dose for these antigens the patients had high antibody levels consistent with potential protection against measles, mumps and hepatitis B, but not against rubella.
  
  
  CONCLUSIONS
  Extra doses of measles-mumps-rubella plus hepatitis B vaccines are recommended in acute lymphoblastic leukemia patients submitted to treatment after hematologic recovery. After this, viral vaccine antibody levels should be verified to define the individual's protective status.
authors.affiliation: Universidade Federal de Sergipe - UFS, Aracaju, SE, Brazil.
authors.forename: Simone Santana
authors.initials: SS
authors.lastname: Viana
authors.forename: Gustavo Santos
authors.initials: GS
authors.lastname: Araujo
authors.forename: Gustavo Baptista de Almeida
authors.initials: GB
authors.lastname: Faro
authors.forename: Lana Luíza
authors.initials: LL
authors.lastname: da Cruz-Silva
authors.forename: Carlos André
authors.initials: CA
authors.lastname: Araújo-Melo
authors.forename: Rosana
authors.initials: R
authors.lastname: Cipolotti