title: IQGAP1: A microtubule-microfilament scaffolding protein with multiple roles in nerve cell development and synaptic plasticity.
abstract: In this article, we review our current understanding of the biology of IQ domain-containing GTPase-Activating Protein 1, IQGAP1, a scaffolding protein with multiple binding partners, which is widely expressed among different cell types, including neurons, and capable of linking Rho-GTPase signaling with cytosleletal elements and environmental cues. Interestingly, a series of recent studies suggest that IQGAP family members have an important role in neuronal development, synaptic plasticity and nervous system disorders involving alterations in spine density.
authors.affiliation: Laboratory of Neurobiology, Instituto Investigación Médica Mercedes y Martín Ferreyra (INIMEC-CONICET), Córdoba, Argentina.
authors.forename: Ignacio
authors.initials: I
authors.lastname: Jausoro
authors.forename: Iván
authors.initials: I
authors.lastname: Mestres
authors.forename: Mónica
authors.initials: M
authors.lastname: Remedi
authors.forename: Mónica
authors.initials: M
authors.lastname: Sanchez
authors.forename: Alfredo
authors.initials: A
authors.lastname: Cáceres
mesh_terms: D000818:Animals; D009473:Neuronal Plasticity / Q000235:genetics*; D009474:Neurons / Q000378:metabolism*; D020703:ras GTPase-Activating Proteins / Q000235:genetics* / Q000378:metabolism
chemical_list: C101203:IQ motif containing GTPase activating protein 1; D020703:ras GTPase-Activating Proteins