title: Are selective serotonin reuptake inhibitors associated with greater apathy in Parkinson's disease?
abstract: Apathy is a common neuropsychiatric feature of Parkinson's disease (PD), but little is known of relationships between apathy and specific medications in PD. Following a retrospective database and chart review of 181 Parkinson's patients, relationships between Apathy Scale scores and use of psychotropic and antiparkinsonian medications were examined with multiple regression. Controlling for age, sex, education, and depression, the use of selective serotonin reuptake inhibitors (SSRIs), but not other antidepressants, was associated with greater apathy. Use of monoamine oxidase B inhibitors was associated with less apathy. Longitudinal studies are needed to evaluate a potential SSRI-induced apathy syndrome in PD.
authors.affiliation: Department of Neurology, Center for Movement Disorders and Neuro-restoration, University of Florida, Gainesville, FL, USA.
authors.forename: Laura B
authors.initials: LB
authors.lastname: Zahodne
authors.forename: Oscar
authors.initials: O
authors.lastname: Bernal-Pacheco
authors.forename: Dawn
authors.initials: D
authors.lastname: Bowers
authors.forename: Herbert
authors.initials: H
authors.lastname: Ward
authors.forename: Genko
authors.initials: G
authors.lastname: Oyama
authors.forename: Natlada
authors.initials: N
authors.lastname: Limotai
authors.forename: Frances
authors.initials: F
authors.lastname: Velez-Lago
authors.forename: Ramon L
authors.initials: RL
authors.lastname: Rodriguez
authors.forename: Irene
authors.initials: I
authors.lastname: Malaty
authors.forename: Nikolaus R
authors.initials: NR
authors.lastname: McFarland
authors.forename: Michael S
authors.initials: MS
authors.lastname: Okun
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000928:Antidepressive Agents / Q000009:adverse effects*; D057565:Apathy / Q000187:drug effects*; D003863:Depression / Q000188:drug therapy* / Q000453:epidemiology / Q000209:etiology; D005260:Female; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D010300:Parkinson Disease / Q000188:drug therapy / Q000453:epidemiology / Q000523:psychology*; D012044:Regression Analysis; D012189:Retrospective Studies; D017367:Selective Serotonin Reuptake Inhibitors / Q000009:adverse effects*
chemical_list: D000928:Antidepressive Agents; D017367:Selective Serotonin Reuptake Inhibitors