title: Neonatal outcomes in pregnancies after bariatric surgery: a retrospective multi-centric cohort study in three French referral centers.
abstract: OBJECTIVE
  To analyze short-term neonatal outcomes in pregnancies after bariatric surgery according to procedure, to the body mass index (BMI) at the beginning of the pregnancy and to the interval from surgery to conception, using a retrospective multi-centric cohort study in three French tertiary perinatal care and bariatric centers.
  
  
  METHODS
  94 neonates in 79 women were included. Frequencies of adverse neonatal events by procedure, laparoscopic adjustable gastric banding (LAGB, n = 63) or Roux-en-Y gastric bypass (RYGB, n = 31), BMI class (72 women with BMI ≥ 30 kg/m(2)) and interval between surgery and conception (43 deliveries of patients who conceived during the first postoperative year) were compared with χ(2) tests. For parametric continuous data, t-tests or analysis of variance were used; non-parametric distributions were compared with the Wilcoxon or Kruskal-Wallis tests.
  
  
  RESULTS
  Significantly lower mean birth weight (2993 g vs. 3253 g; p = 0.02) was observed after RYGB and the mean Z-score for birth weight was significantly closer to 0 in neonates of the LAGB group than in those of the RYGB group. However, no significant differences were noticed regarding small-for-gestational age (32.3% vs. 17.1%; p = 0.06), umbilical arterial blood pH < 7.0 (9.7% vs. 0%; p = 0.11), low Apgar scores, perinatal mortality, and NICU admission. Neonatal outcomes according to the interval from surgery to conception or to the BMI at the beginning of the pregnancy were not significantly different.
  
  
  CONCLUSIONS
  The short-term neonatal outcomes are basically comparable in pregnancies after RYGB than after LAGB.
authors.affiliation: Department of Obstetrics and Gynecology, Assistance Publique-Hôpitaux de Paris (AP-HP), Beaujon Hospital, Université Paris 7, Clichy, France. g.ducarme@gmail.com
authors.forename: Guillaume
authors.initials: G
authors.lastname: Ducarme
authors.forename: Laura
authors.initials: L
authors.lastname: Parisio
authors.forename: Pietro
authors.initials: P
authors.lastname: Santulli
authors.forename: Lionel
authors.initials: L
authors.lastname: Carbillon
authors.forename: Laurent
authors.initials: L
authors.lastname: Mandelbrot
authors.forename: Dominique
authors.initials: D
authors.lastname: Luton
mesh_terms: D050110:Bariatric Surgery / Q000009:adverse effects / Q000379:methods / Q000534:rehabilitation* / Q000706:statistics & numerical data; D001724:Birth Weight / Q000502:physiology; D015331:Cohort Studies; D005260:Female; D005602:France / Q000453:epidemiology; D006801:Humans; D007231:Infant, Newborn; D009767:Obesity, Morbid / Q000453:epidemiology / Q000534:rehabilitation / Q000601:surgery; D011183:Postoperative Complications / Q000453:epidemiology; D011247:Pregnancy; D011248:Pregnancy Complications / Q000453:epidemiology; D011256:Pregnancy Outcome / Q000453:epidemiology*; D012189:Retrospective Studies; D062606:Tertiary Care Centers / Q000706:statistics & numerical data