title: IGF2/ApaI polymorphism associated with birth weight in children of the region of Petrolina-PE, Brazil.
abstract: Insulin-like growth factor 2 (IGF2) gene has an important role in fetal growth. It was investigated association of the IGF2/ApaI polymorphism with low birth weight and normal birth weight (as control) in children attended in Hospital Dom Malan Petrolina, PE-Brazil. The genotype frequencies did not differ statistically between low birth weight (AA = 16.22%, AG = 43.24%, GG = 40.54%) and control (AA = 20% AG = 35%, GG= 45% groups) and the allele frequencies were not significantly different (p > 0.05).The observed genotype frequencies in both groups did not deviate significantly from Hardy-Weinberg equilibrium. Then, no significant correlation was found for this polymorphism in the population studied.
authors.affiliation: Federal University of Vale do São Francisco, Petrolina-PE, Brazil.
authors.forename: Paula F C
authors.initials: PF
authors.lastname: de Mascena Diniz Maia
authors.forename: Tamiris M E
authors.initials: TM
authors.lastname: da Silva
authors.forename: Hildson D
authors.initials: HD
authors.lastname: Angelo
authors.forename: Laís W
authors.initials: LW
authors.lastname: e Silva
authors.forename: Danyelly B
authors.initials: DB
authors.lastname: Gondim Martins
authors.forename: Maria
authors.initials: M
authors.lastname: de Mascena Diniz Maia
authors.forename: José L
authors.initials: JL
authors.lastname: de Lima Filho
mesh_terms: D001724:Birth Weight / Q000235:genetics*; D001938:Brazil; D016022:Case-Control Studies; D002648:Child; D015252:Deoxyribonucleases, Type II Site-Specific / Q000378:metabolism; D005260:Female; D005787:Gene Frequency; D056726:Genetic Association Studies; D005843:Geography; D006801:Humans; D007231:Infant, Newborn; D007335:Insulin-Like Growth Factor II / Q000235:genetics* / Q000378:metabolism; D012150:Polymorphism, Restriction Fragment Length / Q000235:genetics / Q000502:physiology*; D011247:Pregnancy
chemical_list: D007335:Insulin-Like Growth Factor II; D015252:Deoxyribonucleases, Type II Site-Specific; C038485:GGGCCC-specific type II deoxyribonucleases