title: Intestinal amyloidosis with intractable diarrhea and intestinal pseudo-obstruction.
abstract: We report herein a case of intestinal amyloidosis with grave prognosis that caused intractable diarrhea and intestinal pseudo-obstruction, alternately in spite of intensive conservative treatment. A 44-year-old woman was admitted for fever, diarrhea, and crampy abdominal pain which had been continuned during 6 months. Abdomen CT scan showed edematous wall thickening of the small bowel and right colon, and colonoscopic biopsy revealed amyloid deposition in the mucosa. Monoclonal light chains in serum and/or urine were not detected and highly elevated serum amyloid A was shown. In spite of intensive treatment including oral prednisolone and colchicine, diarrhea and intestinal pseudo-obstruction developed alternately, general status rapidly got worsened and died after two months.
authors.affiliation: Departments of Internal Medicine and Pathology, Chonnam National University Medical School, Gwangju, Korea.
authors.forename: Yeon-Joo
authors.initials: YJ
authors.lastname: Kim
authors.forename: Hyun-Soo
authors.initials: HS
authors.lastname: Kim
authors.forename: Seon-Young
authors.initials: SY
authors.lastname: Park
authors.forename: Sang-Woo
authors.initials: SW
authors.lastname: Park
authors.forename: Yoo-Duk
authors.initials: YD
authors.lastname: Choi
authors.forename: Chang-Hwan
authors.initials: CH
authors.lastname: Park
authors.forename: Sung-Kyu
authors.initials: SK
authors.lastname: Choi
authors.forename: Jong-Sun
authors.initials: JS
authors.lastname: Rew
mesh_terms: D000284:Administration, Oral; D000328:Adult; D000686:Amyloidosis / Q000150:complications / Q000175:diagnosis* / Q000188:drug therapy; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D003078:Colchicine / Q000627:therapeutic use; D003113:Colonoscopy; D003967:Diarrhea / Q000209:etiology*; D005260:Female; D006801:Humans; D007413:Intestinal Mucosa / Q000473:pathology; D007418:Intestinal Pseudo-Obstruction / Q000175:diagnosis* / Q000209:etiology; D011239:Prednisolone / Q000627:therapeutic use; D000685:Serum Amyloid A Protein / Q000378:metabolism; D014057:Tomography, X-Ray Computed; D050257:Tubulin Modulators / Q000627:therapeutic use
chemical_list: D000893:Anti-Inflammatory Agents; D000685:Serum Amyloid A Protein; D050257:Tubulin Modulators; D011239:Prednisolone; D003078:Colchicine