title: Comparative efficacy of a spot-on formulation containing emodepside and praziquantel (Profender ®, Bayer) and praziquantel and pyrantel oral tablets (Drontal ® for Cats) against experimental Ancylostoma ceylanicum infections in cats.
abstract: Ancylostoma ceylanicum is a common zoonotic hookworm of dogs and cats throughout Asia and has also been reported to occur within the Australasian region. The aim of this study to was to determine the efficacy of a spot-on formulation containing emodepside and praziquantel (Profender(®), Bayer) and praziquantel and pyrantel oral tablets (Drontal(®) for Cats, Bayer) against experimental A. ceylanicum infections in cats. Twenty-four kittens were each subcutaneously injected with 100 infective third-stage larvae of A. ceylanicum. Kittens were stratified by egg count and randomly allocated equally into control and two treatment groups. The first group were treated with emodepside 2.1%/praziquantel 8.6% (Profender®, Bayer) at the recommended label dose. The second group was treated with 80 mg pyrantel and 20mg praziquantel (Drontal(®) for Cats, Bayer) at the recommended label dose. The kittens in the control group were not treated. Egg counts were performed daily until the end of the study period and compared for the treated and control groups. No eggs were detected in the treated group of kittens within 4 days of treatment and faecal samples from this group remained negative throughout the rest of the study, resulting in a treatment efficacy (egg reduction) of 100% (P<0.0001). The egg counts remained high (993 ± 666 epg) in the untreated control group for the rest of the study period. This study demonstrated that both combination products containing topical emodepside/praziquantel (Profender(®), Bayer) and praziquantel/pyrantel oral tablets (Drontal(®) for Cats, Bayer) given at the recommended dose is highly effective against infection with A. ceylanicum in cats.
authors.affiliation: Department of Pathology, Faculty of Veterinary Science, Chulalongkorn University, Bangkok, Thailand. Piyanan.T@chula.ac.th
authors.forename: Piyanan
authors.initials: P
authors.lastname: Taweethavonsawat
authors.forename: Sudchit
authors.initials: S
authors.lastname: Chungpivat
authors.forename: Supoj
authors.initials: S
authors.lastname: Watanapongchati
authors.forename: Rebecca J
authors.initials: RJ
authors.lastname: Traub
authors.forename: Roland
authors.initials: R
authors.lastname: Schaper
mesh_terms: D000724:Ancylostomiasis / Q000188:drug therapy / Q000662:veterinary*; D000818:Animals; D000969:Antinematodal Agents / Q000627:therapeutic use*; D002371:Cat Diseases / Q000188:drug therapy; D002415:Cats; D047630:Depsipeptides / Q000627:therapeutic use*; D004338:Drug Combinations; D005243:Feces / Q000469:parasitology; D011223:Praziquantel / Q000627:therapeutic use*; D011715:Pyrantel / Q000627:therapeutic use*; D011897:Random Allocation; D016896:Treatment Outcome
chemical_list: D000969:Antinematodal Agents; D047630:Depsipeptides; D004338:Drug Combinations; D011715:Pyrantel; D011223:Praziquantel; C468987:emodepside