title: Serotonin transporter activity of imidazolidine-2,4-dione and imidazo[2,1-f]purine-2,4-dione derivatives in aspect of their acid-base properties.
abstract: Affinities of arylpiperazinylalkyl derivatives of imidazo[2,1-f]purine-2,4-dione and imidazolidine-2,4-dione for serotonin transporter and their acid-base properties were evaluated. The dissociation constant (pK(a)) of compounds 1-22 were determinated by potentiometric titration and calculated using pKalc 3.1 module of the Pallas system. The data from experimental methods and computational calculations were compared and suitable conclusions were reached.
authors.affiliation: Department of Pharmaceutical Chemistry, Jagiellonian University Medical College, Medyczna 9 St, 30-688 Kraków, Poland.
authors.forename: Agnieszka
authors.initials: A
authors.lastname: Zagórska
authors.forename: Anna
authors.initials: A
authors.lastname: Czopek
authors.forename: Maciej
authors.initials: M
authors.lastname: Pawłowski
authors.forename: Małgorzata
authors.initials: M
authors.lastname: Dybała
authors.forename: Agata
authors.initials: A
authors.lastname: Siwek
authors.forename: Gabriel
authors.initials: G
authors.lastname: Nowak