title: Tools to detect delirium superimposed on dementia: a systematic review.
abstract: OBJECTIVE
  To identify valid tools to diagnose delirium superimposed on dementia.
  
  
  METHODS
  Systematic review of studies of delirium tools that explicitly included individuals with dementia.
  
  
  METHODS
  Hospital.
  
  
  METHODS
  Studies were included if delirium assessment tools were validated against standard criteria, and the presence of dementia was assessed according to standard criteria that used validated instruments.
  
  
  METHODS
  PubMed, Embase, and Web of Science databases were searched for articles in English published between January 1960 and January 2012.
  
  
  RESULTS
  Nine studies fulfilled the selection criteria. Of 1,569 participants, 401 had dementia, and 50 had delirium superimposed on dementia. Six delirium tools were evaluated. One study using the Confusion Assessment Method (CAM) with 85% of participants with dementia had high specificity (96-100%) and moderate sensitivity (77%). Two intensive care unit studies that used the CAM for the Intensive Care Unit (CAM-ICU) reported 100% sensitivity and specificity for delirium in 23 individuals with dementia. One study using electroencephalography reported sensitivity of 67% and specificity of 91% in a population with a 100% prevalence of dementia. No studies examined potential effects of dementia severity or subtype on diagnostic accuracy.
  
  
  CONCLUSIONS
  The evidence base on tools for detection of delirium superimposed on dementia is limited, although some existing tools show promise. Further studies of existing or refined tools with larger samples and more-detailed characterization of dementia are required to address the identification of delirium superimposed on dementia.
authors.affiliation: Department of Rehabilitation and Aged Care, Hospital Ancelle, Cremona, Italy. morandi.alessandro@gmail.com
authors.forename: Alessandro
authors.initials: A
authors.lastname: Morandi
authors.forename: Jessica
authors.initials: J
authors.lastname: McCurley
authors.forename: Eduard E
authors.initials: EE
authors.lastname: Vasilevskis
authors.forename: Donna M
authors.initials: DM
authors.lastname: Fick
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Bellelli
authors.forename: Patricia
authors.initials: P
authors.lastname: Lee
authors.forename: James C
authors.initials: JC
authors.lastname: Jackson
authors.forename: Susan D
authors.initials: SD
authors.lastname: Shenkin
authors.lastname: Marcotrabucchi
authors.forename: John
authors.initials: J
authors.lastname: Schnelle
authors.forename: Sharon K
authors.initials: SK
authors.lastname: Inouye
authors.forename: E Wesley
authors.initials: EW
authors.lastname: Ely
authors.forename: Wesley E
authors.initials: WE
authors.lastname: Ely
authors.forename: Alasdair
authors.initials: A
authors.lastname: MacLullich
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003693:Delirium / Q000150:complications* / Q000175:diagnosis*; D003704:Dementia / Q000150:complications*; D003943:Diagnostic Techniques, Neurological; D006801:Humans; D008875:Middle Aged