title: Multiple resonance fiber-optic sensor with time division multiplexing for multianalyte detection.
abstract: A proof-of-concept multiwindow fiber-optic sensor utilizing multiple particle plasmon resonance (PPR) of silver nanoparticles and gold nanorods separately on two unclad portions of the fiber for multianalyte detection is demonstrated. The detection is based on intensity interrogation of multiple wavelengths by a single detector. Time division multiplexing is employed to modulate the illumination of dual-wavelength LEDs to induce PPRs for simultaneous real-time and label-free monitoring of two types of biomolecular interactions. Preliminary results reveal that a refractive index resolution of 9 ×10(-6) RIU is achieved. Moreover, the measured intensities of two windows independently respond to their respective binding events. The potential of the sensor architecture with multiple sensing windows for cascaded, higher throughput, and multianalyte biochemical detection can be expected.
authors.affiliation: Center for Nano Bio-Detection, National Chung Cheng University, 168 University Road, Chiayi 621, Taiwan.
authors.forename: Hsing-Ying
authors.initials: HY
authors.lastname: Lin
authors.forename: Chen-Han
authors.initials: CH
authors.lastname: Huang
authors.forename: Chia-Chi
authors.initials: CC
authors.lastname: Huang
authors.forename: Yu-Chia
authors.initials: YC
authors.lastname: Liu
authors.forename: Lai-Kwan
authors.initials: LK
authors.lastname: Chau
mesh_terms: D000614:Aminocaproates / Q000737:chemistry; D000818:Animals; D002417:Cattle; D053768:Metal Nanoparticles / Q000737:chemistry; D055100:Optical Fibers; D012834:Silver / Q000737:chemistry; D019809:Streptavidin / Q000737:chemistry; D020349:Surface Plasmon Resonance / Q000295:instrumentation*; D013997:Time Factors
chemical_list: D000614:Aminocaproates; C031746:6-N-(2,4-dinitrophenyl)aminohexanoic acid; D012834:Silver; D019809:Streptavidin