title: Ribotyping of Clostridium difficile strains associated with nosocomial transmission and relapses in a Swedish County.
abstract: Clostridium difficile is an emerging threat in hospital environments. To analyse possible transmission and to distinguish between relapse and reinfection a collection of C. difficile isolates, sampled from 162 consecutive episodes of C. difficile infection, were PCR ribotyped. Two ribotypes (001 and 012) were prone to cause nosocomial acquisition. Moreover, ribotype 001 had a tendency to cause relapses as almost one in two patients with this ribotype had one or more relapses. By using PCR ribotyping strains inclined to cause relapses and strains associated with hospital transmission might be detected. This enables optimized hygiene measures and may improve the choice of treatment regimen.
authors.affiliation: Department of Infectious Diseases, County Hospital Ryhov, Jönköping, Sweden.
authors.forename: Cecilia
authors.initials: C
authors.lastname: Magnusson
authors.forename: Marlene
authors.initials: M
authors.lastname: Wullt
authors.forename: Sture
authors.initials: S
authors.lastname: Löfgren
authors.forename: Peter
authors.initials: P
authors.lastname: Iveroth
authors.forename: Tomas
authors.initials: T
authors.lastname: Akerlund
authors.forename: Andreas
authors.initials: A
authors.lastname: Matussek
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology; D016360:Clostridioides difficile / Q000145:classification / Q000235:genetics / Q000302:isolation & purification* / Q000472:pathogenicity*; D003428:Cross Infection / Q000453:epidemiology / Q000382:microbiology*; D004761:Enterocolitis, Pseudomembranous / Q000453:epidemiology / Q000382:microbiology*; D006801:Humans; D058889:Molecular Typing; D016133:Polymerase Chain Reaction; D012008:Recurrence; D021521:Ribotyping; D013548:Sweden / Q000453:epidemiology
chemical_list: D000900:Anti-Bacterial Agents