title: The role of HIV infection, cognition, and depression in risky decision-making.
abstract: The authors examined the impact of HIV, cognitive dysfunction, and depression on decision-making. HIV+ (N=100) and HIV- (N=26) participants were administered a comprehensive neuropsychological battery, a modified version of the Iowa Gambling Task, and a measure of depressive symptoms. HIV+ participants demonstrated more difficulties in learning the gambling task than did HIV- participants. Executive functioning and depression emerged as strong predictors of gambling task performance. Depression partially mediated the relationship between executive functioning and gambling performance. Our findings suggest that HIV infection, executive dysfunction, and depression place individuals at risk for poor decision-making.
authors.affiliation: Semel Institute for Neuroscience and Human Behavior, UCLA School of Medicine, Los Angeles, CA, USA. athames@mednet.ucla
authors.forename: April D
authors.initials: AD
authors.lastname: Thames
authors.forename: Vanessa
authors.initials: V
authors.lastname: Streiff
authors.forename: Sapna M
authors.initials: SM
authors.lastname: Patel
authors.forename: Stella E
authors.initials: SE
authors.lastname: Panos
authors.forename: Steven A
authors.initials: SA
authors.lastname: Castellon
authors.forename: Charles H
authors.initials: CH
authors.lastname: Hinkin
mesh_terms: D000328:Adult; D003072:Cognition Disorders / Q000209:etiology* / Q000523:psychology; D003657:Decision Making / Q000502:physiology*; D003863:Depression / Q000209:etiology* / Q000523:psychology; D005260:Female; D005717:Games, Experimental; D015658:HIV Infections / Q000150:complications* / Q000523:psychology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests; D011569:Psychiatric Status Rating Scales; D012044:Regression Analysis; D012309:Risk-Taking; D018709:Statistics, Nonparametric