title: Cerebrospinal fluid biomarkers in neurological diseases in children.
abstract: Analysis of cerebrospinal fluid (CSF) biomarkers is an integral part of neurology. Basic CSF biomarkers, such as CSF/serum albumin ratio and CSF cell counts, have been used to diagnose inflammatory and infectious CNS disorders in adults and children for decades. During recent years, however, numerous biomarkers for neuronal and astroglial injury, as well as disease-specific protein inclusions, have been developed for neurodegenerative disorders in adults. The overall aim of this paper is to give an updated overview of some of these biomarkers with special focus on their possible relevance to neurological disorders in children and adolescents.
authors.affiliation: Clinical Neurochemistry Laboratory, Institute of Neuroscience and Physiology, Department of Neurochemistry, Sahlgrenska University Hospital/Mölndal, Göteborgsvägen 33, S-431 80 Mölndal, Sweden. pashtun.shahim@neuro.gu.se
authors.forename: Pashtun
authors.initials: P
authors.lastname: Shahim
authors.forename: Jan-Eric
authors.initials: JE
authors.lastname: Månsson
authors.forename: Niklas
authors.initials: N
authors.lastname: Darin
authors.forename: Henrik
authors.initials: H
authors.lastname: Zetterberg
authors.forename: Niklas
authors.initials: N
authors.lastname: Mattsson
mesh_terms: D015415:Biomarkers / Q000134:cerebrospinal fluid*; D002555:Cerebrospinal Fluid / Q000737:chemistry*; D002648:Child; D006801:Humans; D019636:Neurodegenerative Diseases / Q000134:cerebrospinal fluid*
chemical_list: D015415:Biomarkers