title: Acyclic cucurbit[n]uril-type molecular containers bind neuromuscular blocking agents in vitro and reverse neuromuscular block in vivo.
abstract: Be my guest: two acyclic cucurbit[n]uril-type receptors that carry SO(3) (-) -groups bind tightly to several commonly used neuromuscular blocking agents, such as rocuronium, in aqueous solution as revealed by direct and competitive UV/Vis binding assays. One of these containers functions as a potent reversal agent for rocuronium-induced neuromuscular block in rats.
authors.affiliation: Department of Chemistry and Biochemistry, University of Maryland, College Park, 20742, USA.
authors.forename: Da
authors.initials: D
authors.lastname: Ma
authors.forename: Ben
authors.initials: B
authors.lastname: Zhang
authors.forename: Ulrike
authors.initials: U
authors.lastname: Hoffmann
authors.forename: Martina Grosse
authors.initials: MG
authors.lastname: Sundrup
authors.forename: Matthias
authors.initials: M
authors.lastname: Eikermann
authors.forename: Lyle
authors.initials: L
authors.lastname: Isaacs
mesh_terms: D000818:Animals; D001952:Bridged-Ring Compounds / Q000494:pharmacology*; D006801:Humans; D007093:Imidazoles / Q000494:pharmacology*; D007700:Kinetics; D008958:Models, Molecular; D019148:Neuromuscular Blockade / Q000379:methods*; D009466:Neuromuscular Blocking Agents / Q000494:pharmacology*; D009469:Neuromuscular Junction / Q000187:drug effects / Q000378:metabolism; D051381:Rats; D013056:Spectrophotometry, Ultraviolet; D047028:Macrocyclic Compounds; D000099246:Cucurbit(n)urils
chemical_list: D001952:Bridged-Ring Compounds; D007093:Imidazoles; D009466:Neuromuscular Blocking Agents; C507827:cucurbit(10)uril; D047028:Macrocyclic Compounds; D000099246:Cucurbit(n)urils