title: Structures of human acetylcholinesterase in complex with pharmacologically important ligands.
abstract: Human acetylcholinesterase (AChE) is a significant target for therapeutic drugs. Here we present high resolution crystal structures of human AChE, alone and in complexes with drug ligands; donepezil, an Alzheimer's disease drug, binds differently to human AChE than it does to  Torpedo  AChE. These crystals of human AChE provide a more accurate platform for further drug development than previously available.
authors.affiliation: New York Structural Biology Center, New York, New York 10027, USA.
authors.forename: Jonah
authors.initials: J
authors.lastname: Cheung
authors.forename: Michael J
authors.initials: MJ
authors.lastname: Rudolph
authors.forename: Fiana
authors.initials: F
authors.lastname: Burshteyn
authors.forename: Michael S
authors.initials: MS
authors.lastname: Cassidy
authors.forename: Ebony N
authors.initials: EN
authors.lastname: Gary
authors.forename: James
authors.initials: J
authors.lastname: Love
authors.forename: Matthew C
authors.initials: MC
authors.lastname: Franklin
authors.forename: Jude J
authors.initials: JJ
authors.lastname: Height
mesh_terms: D000110:Acetylcholinesterase / Q000737:chemistry* / Q000378:metabolism; D000122:Acetylthiocholine / Q000378:metabolism; D000818:Animals; D002800:Cholinesterase Inhibitors / Q000378:metabolism*; D018360:Crystallography, X-Ray; D000077265:Donepezil; D006801:Humans; D007189:Indans / Q000378:metabolism*; D008958:Models, Molecular; D010880:Piperidines / Q000378:metabolism*; D011487:Protein Conformation; D014101:Torpedo / Q000378:metabolism*
chemical_list: D002800:Cholinesterase Inhibitors; D007189:Indans; D010880:Piperidines; D000122:Acetylthiocholine; D000077265:Donepezil; D000110:Acetylcholinesterase