title: Base-mediated carboxylation of unprotected indole derivatives with carbon dioxide.
abstract: A simple and straightforward method for the preparation of indole-3-carboxylic acids was discovered through the direct carboxylation of indoles with atmospheric pressure of carbon dioxide (CO(2)) under basic conditions. The key for the reaction was found to be the use of a large excess of LiO(t)Bu as a base to suppress the undesired decarboxylation side reaction.
authors.affiliation: Department of Chemistry, School of Science, The University of Tokyo, 7-3-1, Hongo, Tokyo, 113-0033, Japan.
authors.forename: Woo-Jin
authors.initials: WJ
authors.lastname: Yoo
authors.forename: Montse Guiteras
authors.initials: MG
authors.lastname: Capdevila
authors.forename: Xiangwei
authors.initials: X
authors.lastname: Du
authors.forename: Shū
authors.initials: S
authors.lastname: Kobayashi