title: Applications and potential toxicity of magnetic iron oxide nanoparticles.
abstract: Owing to their unique physical and chemical properties, magnetic iron oxide nanoparticles have become a powerful platform in many diverse aspects of biomedicine, including magnetic resonance imaging, drug and gene delivery, biological sensing, and hyperthermia. However, the biomedical applications of magnetic iron oxide nanoparticles arouse serious concerns about their pharmacokinetics, metabolism, and toxicity. In this review, the updated research on the biomedical applications and potential toxicity of magnetic iron oxide nanoparticles is summarized. Much more effort is required to develop magnetic iron oxide nanoparticles with improved biocompatible surface engineering to achieve minimal toxicity, for various applications in biomedicine.
authors.affiliation: Center for Molecular Imaging and Translational Medicine, School of Public Health, Xiamen University, Xiamen 361005, China. gangliu.cmitm@xmu.edu.cn
authors.forename: Gang
authors.initials: G
authors.lastname: Liu
authors.forename: Jinhao
authors.initials: J
authors.lastname: Gao
authors.forename: Hua
authors.initials: H
authors.lastname: Ai
authors.forename: Xiaoyuan
authors.initials: X
authors.lastname: Chen
mesh_terms: D000818:Animals; D035843:Biomedical Research; D005290:Ferric Compounds / Q000737:chemistry*; D006801:Humans; D008280:Magnetics; D053768:Metal Nanoparticles / Q000633:toxicity*; D051379:Mice; D013499:Surface Properties
chemical_list: D005290:Ferric Compounds; C000499:ferric oxide