title: The knowns and unknowns of the immunopathogenesis of tuberculosis.
abstract: In this review, we discuss the 'knowns' and 'unknowns' of host defence towards Mycobacterium tuberculosis. With regard to the 'knowns', both protective and immunopathogenic mechanisms are discussed, including recently discovered new pathways  of host defence and inflammatory immunopathology. With regard to the 'unknowns', there will be emphasis on unanswered key questions, accompanied by a perspective on needs and priorities for future research. The role of the inflammatory response and its dysregulation in tuberculosis-related  immune reconstitution inflammatory syndrome will also be discussed.
authors.affiliation: Department of Infectious Diseases, Leiden University Medical Center, Leiden, The Netherlands. t.h.m.ottenhoff@lumc.nl
authors.forename: T H M
authors.initials: TH
authors.lastname: Ottenhoff
mesh_terms: D000818:Animals; D054884:Host-Pathogen Interactions / Q000276:immunology; D006801:Humans; D054019:Immune Reconstitution Inflammatory Syndrome / Q000276:immunology / Q000382:microbiology; D007249:Inflammation / Q000276:immunology* / Q000382:microbiology / Q000503:physiopathology; D009169:Mycobacterium tuberculosis / Q000276:immunology*; D014376:Tuberculosis / Q000276:immunology* / Q000503:physiopathology