title: Antibacterial activity of selected metabolites from Chilean lichen species against methicillin-resistant staphylococci.
abstract: The in vitro antibacterial activities of eight compounds isolated from lichens, collected in several Southern regions of Chile (including Antarctica), were evaluated against methicillin-resistant clinical isolates strains of Staphylococcus aureus, Staphylococcus haemolyticus and Staphylococcus warneri. The minimum inhibitory concentrations, calculated in microdilution, were ranging from 8 µg mL(-1) for sphaerophorin to 1024 µg mL(-1) for fumarprotocetraric acid. These findings suggest, however, that the natural compounds from lichens are good candidates for the individuation of novel templates for the development of new antimicrobial agents or combinations of drugs for chemotherapy.
authors.affiliation: Department of Biomedical Sciences and Technologies, University of l'Aquila, l'Aquila, Italy. celenza@univaq.it
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Celenza
authors.forename: Bernardetta
authors.initials: B
authors.lastname: Segatore
authors.forename: Domenico
authors.initials: D
authors.lastname: Setacci
authors.forename: Mariagrazia
authors.initials: M
authors.lastname: Perilli
authors.forename: Fabrizia
authors.initials: F
authors.lastname: Brisdelli
authors.forename: Pierangelo
authors.initials: P
authors.lastname: Bellio
authors.forename: Marisa
authors.initials: M
authors.lastname: Piovano
authors.forename: Juan A
authors.initials: JA
authors.lastname: Garbarino
authors.forename: Gianfranco
authors.initials: G
authors.lastname: Amicosante
authors.forename: Marcello
authors.initials: M
authors.lastname: Nicoletti
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry* / Q000494:pharmacology*; D008011:Lichens / Q000737:chemistry*; D055624:Methicillin-Resistant Staphylococcus aureus / Q000187:drug effects*; D008826:Microbial Sensitivity Tests; D013210:Staphylococcus / Q000187:drug effects
chemical_list: D000900:Anti-Bacterial Agents