title: Gene-diet interactions on plasma lipid levels in the Inuit population.
abstract: The Inuit population is often described as being protected against CVD due to their traditional dietary patterns and their unique genetic background. The objective of the present study was to examine gene-diet interaction effects on plasma lipid levels in the Inuit population. Data from the Qanuippitaa Nunavik Health Survey (n 553) were analysed via regression models which included the following: genotypes for thirty-five known polymorphisms (SNP) from twenty genes related to lipid metabolism; dietary fat intake including total fat (TotFat) and saturated fat (SatFat) estimated from a FFQ; plasma lipid levels, namely total cholesterol (TC), LDL-cholesterol (LDL-C), HDL-cholesterol (HDL-C) and TAG. The results demonstrate that allele frequencies were different in the Inuit population compared with the Caucasian population. Further, seven SNP (APOA1 - 75G/A (rs670), APOB XbAI (rs693), AGT M235T (rs699), LIPC 480C/T (rs1800588), APOA1 84T/C (rs5070), PPARG2 - 618C/G (rs10865710) and APOE 219G/T (rs405509)) in interaction with TotFat and SatFat were significantly associated with one or two plasma lipid parameters. Another four SNP (APOC3 3238C>G (rs5128), CETP I405V (rs5882), CYP1A1 A4889G (rs1048943) and ABCA1 Arg219Lys (rs2230806)) in interaction with either TotFat or SatFat intake were significantly associated with one plasma lipid variable. Further, an additive effect of these SNP in interaction with TotFat or SatFat intake was significantly associated with higher TC, LDL-C or TAG levels, as well as with lower HDL-C levels. In conclusion, the present study supports the notion that gene-diet interactions play an important role in modifying plasma lipid levels in the Inuit population.
authors.affiliation: Institute of Nutraceuticals and Functional Foods, Laval University, Pavillon des Services, Bureau 2729K, 2440, Boulevard Hochelaga, Quebec City, QC, Canada G1V 0A6.
authors.forename: Iwona
authors.initials: I
authors.lastname: Rudkowska
authors.forename: Eric
authors.initials: E
authors.lastname: Dewailly
authors.forename: Robert A
authors.initials: RA
authors.lastname: Hegele
authors.forename: Véronique
authors.initials: V
authors.lastname: Boiteau
authors.forename: Ariane
authors.initials: A
authors.lastname: Dubé-Linteau
authors.forename: Belkacem
authors.initials: B
authors.lastname: Abdous
authors.forename: Yves
authors.initials: Y
authors.lastname: Giguere
authors.forename: Marie-Ludivine
authors.initials: ML
authors.lastname: Chateau-Degat
authors.forename: Marie-Claude
authors.initials: MC
authors.lastname: Vohl
mesh_terms: D000328:Adult; D004247:DNA / Q000097:blood; D004032:Diet / Q000208:ethnology*; D015930:Diet Records; D004041:Dietary Fats / Q000008:administration & dosage; D005260:Female; D005787:Gene Frequency / Q000235:genetics; D005838:Genotype; D006306:Health Surveys; D006801:Humans; D004930:Inuit / Q000208:ethnology / Q000235:genetics*; D050356:Lipid Metabolism / Q000235:genetics*; D008055:Lipids / Q000097:blood*; D008297:Male; D020641:Polymorphism, Single Nucleotide / Q000235:genetics; D044465:White People / Q000235:genetics
chemical_list: D004041:Dietary Fats; D008055:Lipids; D004247:DNA