title: Asymmetric organocatalytic decarboxylative Mannich reaction using β-keto acids: A new protocol for the synthesis of chiral β-amino ketones.
abstract: The first decarboxylative Mannich reaction employing β-keto acids, catalyzed by cinchonine-derived bifunctional thiourea catalyst has been described. The desired β-amino ketones were obtained in excellent yields and with moderate to good enantioselectivities.
authors.affiliation: Department of Chemistry & Medicinal Chemistry Program, Life Sciences Institute, National University of Singapore, 3 Science Drive 3, Republic of Singapore, 117543.
authors.forename: Chunhui
authors.initials: C
authors.lastname: Jiang
authors.forename: Fangrui
authors.initials: F
authors.lastname: Zhong
authors.forename: Yixin
authors.initials: Y
authors.lastname: Lu