title: HCN1 channels: a new therapeutic target for depressive disorders?
abstract: The hyperpolarization-activated cyclic nucleotide-gated channels are cation channels that are activated by hyperpolarizing potentials. These channels are concentrated in cortical and hippocampal pyramidal cell dendrites, where they play an important role in determining synaptic input integration and thus neuronal output. These channels have thus been suggested to be involved in physiological processes such as cognition as well as pathophysiological states such as epilepsy. Recent evidence suggests that these channels may also be therapeutic targets for treatment of depressive disorders.
authors.affiliation: UCL School of Pharmacy, University College, London WC1N 1AX, UK. mala.shah@ucl.ac.uk
authors.forename: Mala M
authors.initials: MM
authors.lastname: Shah
mesh_terms: D000778:Anesthetics, Dissociative / Q000494:pharmacology; D000818:Animals; D019208:Brain-Derived Neurotrophic Factor / Q000235:genetics / Q000378:metabolism; D054815:Cyclic Nucleotide-Gated Cation Channels / Q000037:antagonists & inhibitors / Q000235:genetics / Q000378:metabolism*; D003712:Dendrites / Q000378:metabolism*; D003866:Depressive Disorder / Q000235:genetics / Q000378:metabolism* / Q000628:therapy; D015870:Gene Expression / Q000187:drug effects; D006801:Humans; D064428:Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels; D007649:Ketamine / Q000494:pharmacology; D008957:Models, Genetic; D015221:Potassium Channels / Q000235:genetics / Q000378:metabolism*; D017966:Pyramidal Cells / Q000378:metabolism*; D034622:RNA Interference
chemical_list: D000778:Anesthetics, Dissociative; D019208:Brain-Derived Neurotrophic Factor; D054815:Cyclic Nucleotide-Gated Cation Channels; C578665:HCN1 protein, human; D064428:Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels; D015221:Potassium Channels; D007649:Ketamine