title: Hypothermia and hemostasis in severe trauma:  A new crossroads workshop report.
abstract: OBJECTIVE
  The hypothermia and hemostasis in severe trauma (HYPOSTAT): a new crossroads workshop was convened to evaluate the interplay among hypothermia, hemostasis, and severe trauma/hemorrhage. Trauma is the major cause of death in young individuals in the United States, with uncontrolled hemorrhage representing the major cause of preventable deaths.
  
  
  METHODS
  This workshop organized by the National Heart, Lung, and Blood Institute and the US Army Medical Research and Material Command as a forum for exchange of ideas among experts from diverse fields. The specific workshop goals were to (1) identify state-of-the-art and needs in knowledge of biology of hypothermia and hemostasis in the setting of significant traumatic injury; (2) provide an interdisciplinary forum to enhance knowledge regarding early detection of traumatic shock and monitoring of the level and effect of controlled hypothermia in severe trauma settings; and (3) identify future research directions of the role of therapeutic-oriented hypothermia and hemostasis in trauma with severe blood loss.
  
  
  METHODS
  Not applicable.
  
  
  METHODS
  Expert opinion and literature review.
  
  
  CONCLUSIONS
  This document provides a summary of the expert opinion and highlights the recommendations that came out of the discussions at this workshop to guide scientific efforts in basic, translational, and clinical research in this area.
authors.affiliation: Massachusetts General Hospital, Boston, Massachusetts, USA.
authors.forename: Hasan B
authors.initials: HB
authors.lastname: Alam
authors.forename: Anthony E
authors.initials: AE
authors.lastname: Pusateri
authors.forename: Andrei
authors.initials: A
authors.lastname: Kindzelski
authors.forename: Debra
authors.initials: D
authors.lastname: Egan
authors.forename: Keith
authors.initials: K
authors.lastname: Hoots
authors.forename: Matthew T
authors.initials: MT
authors.lastname: Andrews
authors.forename: Peter
authors.initials: P
authors.lastname: Rhee
authors.forename: Samuel
authors.initials: S
authors.lastname: Tisherman
authors.forename: Kenneth
authors.initials: K
authors.lastname: Mann
authors.forename: Jaroslav
authors.initials: J
authors.lastname: Vostal
authors.forename: Patrick M
authors.initials: PM
authors.lastname: Kochanek
authors.forename: Thomas
authors.initials: T
authors.lastname: Scalea
authors.forename: Virgil
authors.initials: V
authors.lastname: Deal
authors.forename: Forest
authors.initials: F
authors.lastname: Sheppard
authors.forename: George
authors.initials: G
authors.lastname: Sopko
mesh_terms: D035843:Biomedical Research; D006470:Hemorrhage / Q000097:blood / Q000209:etiology*; D006487:Hemostasis; D006801:Humans; D007035:Hypothermia / Q000097:blood / Q000209:etiology*; D015599:Trauma Severity Indices; D014947:Wounds and Injuries / Q000097:blood / Q000150:complications* / Q000175:diagnosis