title: Doppler-assessed cerebral blood flow velocity in the neonate as estimator of global cerebral blood volume flow measured using phase-contrast magnetic resonance angiography.
abstract: BACKGROUND
  We hypothesized that color Doppler-measured cerebral blood flow velocity (CD-CBFV) as measured in the three feeding arteries of the brain can be used as an estimator of global cerebral blood flow.
  
  
  METHODS
  CD-CBFV was determined as soon as possible after determination of phase-contrast magnetic resonance angiography-measured blood volume flow (PC-MRA BVF) by adding up angle-corrected time-averaged mean flow velocities of both internal carotid arteries and basilar artery. 30 newborns (gestational age ranging from 25 to 42 weeks; actual weight ranging from 1,050 to 5,858 g; postconceptional age ranging from 225 to 369 days) were investigated.
  
  
  RESULTS
  Doppler-determined CBFV ranged from 37 to 131 cm/s with a median of 69 cm/s. CD-CBFV showed a positive correlation with actual weight (r = 0.56, p < 0.01) and postconceptional age (r = 0.53, p < 0.01). CD-CBFV correlated positively with PC-MRA-measured BVF (r = 0.51, p < 0.01). Gestational age at birth, mechanical ventilation or gender did not influence this relationship. The limits of agreement, however, are wide, especially at higher CD-CBFV- and PC-MRA-measured BVF.
  
  
  CONCLUSIONS
  CD-CBFV may be used as a non-invasive trend-monitoring tool to detect gross changes in global cerebral blood flow in the unstable and sick neonate.
authors.affiliation: Department of Neonatology, Wilhelmina Children's Hospital/University Medical Center, Utrecht, The Netherlands. m.benders @ umcutrecht.nl
authors.forename: Manon J N L
authors.initials: MJ
authors.lastname: Benders
authors.forename: Jeroen
authors.initials: J
authors.lastname: Hendrikse
authors.forename: Linda
authors.initials: L
authors.lastname: de Vries
authors.forename: Floris
authors.initials: F
authors.lastname: Groenendaal
authors.forename: Frank
authors.initials: F
authors.lastname: van Bel
mesh_terms: D001724:Birth Weight / Q000502:physiology; D001783:Blood Flow Velocity / Q000502:physiology*; D001810:Blood Volume / Q000502:physiology*; D001921:Brain / Q000098:blood supply*; D002343:Carotid Artery, Internal / Q000000981:diagnostic imaging; D002560:Cerebrovascular Circulation / Q000502:physiology*; D004453:Echoencephalography / Q000379:methods; D005260:Female; D005865:Gestational Age; D006801:Humans; D007223:Infant; D007231:Infant, Newborn / Q000502:physiology; D007234:Infant, Premature / Q000502:physiology; D018810:Magnetic Resonance Angiography / Q000379:methods*; D008297:Male; D013223:Statistics as Topic / Q000379:methods; D047929:Term Birth / Q000502:physiology; D017585:Ultrasonography, Doppler, Transcranial / Q000379:methods / Q000706:statistics & numerical data