title: [Analysis of 8-OH-DPAT and NAN-190 effects in young prenatally stressed rats under experimental estrogen deficiency conditions].
abstract: The present work was aimed at a comparative investigation of the effects of chronic administration of the 5-HT1A receptor agonist 8-OH-DPAT (0.05 mg/kg, s.c.) and 5-HT1A receptors antagonist NAN-190 (0.1 mg/kg, i.p.) for 14 days on anxiety-like behavior in prenatally stressed female with the experimental estrogen deficiency induced by ovariectomy. Chronic administration of 8-OH-DPAT to ovariectomized prenatally stressed females resulted in an anxiolytic effect and led to correction of the impaired levels of follitropine and estradiol. Administration of NAN-190 to ovariectomized prenatally stressed females increased the level of anxiety and more profoundly destroyed a relation between the levels of gonadotropic hormones and peripheral gonadal hormones.
authors.forename: Iu O
authors.initials: IuO
authors.lastname: Fedotova
authors.forename: S G
authors.initials: SG
authors.lastname: Pivina
authors.forename: N É
authors.initials: NÉ
authors.lastname: Ordian
mesh_terms: D017371:8-Hydroxy-2-(di-n-propylamino)tetralin / Q000494:pharmacology*; D000818:Animals; D001007:Anxiety / Q000097:blood / Q000209:etiology / Q000503:physiopathology; D001522:Behavior, Animal / Q000187:drug effects; D004967:Estrogens / Q000172:deficiency*; D005260:Female; D008297:Male; D010052:Ovariectomy; D010879:Piperazines / Q000494:pharmacology*; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects / Q000097:blood / Q000503:physiopathology; D051381:Rats; D017208:Rats, Wistar; D017366:Serotonin Receptor Agonists / Q000494:pharmacology*; D013312:Stress, Physiological / Q000187:drug effects*
chemical_list: D004967:Estrogens; D010879:Piperazines; D017366:Serotonin Receptor Agonists; C058895:1-(2-methoxyphenyl)-4-(4-(2-phthalimido)butyl)piperazine; D017371:8-Hydroxy-2-(di-n-propylamino)tetralin