title: Effects of a diet high in salt, fat, and sugar on telemetric blood pressure measurements in conscious, unrestrained adult Yucatan miniature swine (Sus scrofa).
abstract: Radiotelemetry was used to evaluate diet-related elevation of blood pressure in adult Yucatan miniature swine. Systolic arterial blood pressure (SAP), diastolic atrial blood pressure (DAP), heart rate, and locomotor activity were assessed in 9- or 11-mo-old Yucatan miniature pigs fed  a standard diet or a North American-type diet high in salt, fat, and sugar (HSFS). Compared with pigs fed standard diet, pigs fed HSFS diet showed markedly elevated SAP (132 ± 3 compared with 156 ± 6 mm Hg), whereas DAP was unchanged (92 ± 2 compared with 99 ± 5  mm Hg). In addition, all pigs were modestly sensitive to short-term changes in dietary salt, as indicated by a 6% to 7% response in blood pressure parameters. According to these data, the increase in SAP for pigs on the HSFS diet was too large to be explained by the NaCl content of the diet  alone. We found no evidence of endothelial dysfunction, and the relaxation responses of isolated coronary arteries actually were enhanced in the HSFS group. In conclusion, in a Yucatan miniature pigs model chronically fed a HSFS diet, DAP did not increase, but SAP and pulse pressure appeared  to be affected by high dietary levels of fat or sugar (or both).
authors.affiliation: Department of Biochemistry, Memorial University of Newfoundland, St John's, Newfoundland and Labrador, Canada.
authors.forename: Semone B
authors.initials: SB
authors.lastname: Myrie
authors.forename: Leslie L
authors.initials: LL
authors.lastname: McKnight
authors.forename: J Christopher
authors.initials: JC
authors.lastname: King
authors.forename: John J
authors.initials: JJ
authors.lastname: McGuire
authors.forename: Bruce N
authors.initials: BN
authors.lastname: Van Vliet
authors.forename: Robert F
authors.initials: RF
authors.lastname: Bertolo
mesh_terms: D000818:Animals; D001794:Blood Pressure / Q000187:drug effects*; D059305:Diet, High-Fat / Q000009:adverse effects*; D019422:Dietary Sucrose / Q000009:adverse effects*; D006339:Heart Rate / Q000187:drug effects; D008124:Locomotion / Q000187:drug effects; D017673:Sodium Chloride, Dietary / Q000009:adverse effects*; D013552:Swine; D013556:Swine, Miniature; D013686:Telemetry / Q000662:veterinary
chemical_list: D019422:Dietary Sucrose; D017673:Sodium Chloride, Dietary