title: Markov random field and Gaussian mixture for segmented MRI-based partial volume correction in PET.
abstract: In this paper we propose a segmented magnetic resonance imaging (MRI) prior-based maximum penalized likelihood deconvolution technique for positron emission tomography (PET) images. The model assumes the existence of activity classes that behave like a hidden Markov random field (MRF) driven by the segmented MRI. We utilize a mean field approximation to compute the likelihood of the MRF. We tested our method on both simulated and clinical data (brain PET) and compared our results with PET images corrected with the re-blurred Van Cittert (VC) algorithm, the simplified Guven (SG) algorithm and the region-based voxel-wise (RBV) technique. We demonstrated our algorithm outperforms the VC algorithm and outperforms SG and RBV corrections when the segmented MRI is inconsistent (e.g. mis-segmentation, lesions, etc) with the PET image.
authors.affiliation: Institute of Nuclear Medicine, University College London, London NW1 2BU, UK. a.bousse@ucl.ac.uk
authors.forename: Alexandre
authors.initials: A
authors.lastname: Bousse
authors.forename: Stefano
authors.initials: S
authors.lastname: Pedemonte
authors.forename: Benjamin A
authors.initials: BA
authors.lastname: Thomas
authors.forename: Kjell
authors.initials: K
authors.lastname: Erlandsson
authors.forename: Sébastien
authors.initials: S
authors.lastname: Ourselin
authors.forename: Simon
authors.initials: S
authors.lastname: Arridge
authors.forename: Brian F
authors.initials: BF
authors.lastname: Hutton
mesh_terms: D000544:Alzheimer Disease / Q000000981:diagnostic imaging; D001921:Brain / Q000000981:diagnostic imaging; D004827:Epilepsy / Q000000981:diagnostic imaging; D019788:Fluorodeoxyglucose F18; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008390:Markov Chains; D016011:Normal Distribution; D019047:Phantoms, Imaging; D049268:Positron-Emission Tomography / Q000379:methods*; D015203:Reproducibility of Results
chemical_list: D019788:Fluorodeoxyglucose F18