title: In vitro antibacterial activity and synergistic antibiotic effects of phlorotannins isolated from Eisenia bicyclis against methicillin-resistant Staphylococcus aureus.
abstract: Six phlorotannins, isolated from Eisenia bicyclis, were evaluated for antibacterial activity against methicillin-resistant Staphylococcus aureus (MRSA). The minimum inhibitory concentrations (MIC) of the compounds were in the range 32 to 64 µg/mL. Phlorofucofuroeckol-A (PFF) exhibited the highest anti-MRSA activity, with an MIC of 32 µg/mL. An investigation of the interaction between these compounds and the β-lactam antibiotics ampicillin, penicillin, and oxacillin revealed synergistic action against MRSA in combination with compound PFF. To our knowledge, this is the first report on the anti-MRSA activity of phlorotannins from E. bicyclis. The results obtained in this study suggest that the compounds derived from E. bicyclis can be a good source of natural antibacterial agents against MRSA.
authors.affiliation: Department of Food Science and Technology, Pukyong National University, Busan, Republic of Korea.
authors.forename: Sung-Hwan
authors.initials: SH
authors.lastname: Eom
authors.forename: Do-Hyung
authors.initials: DH
authors.lastname: Kim
authors.forename: Sang-Hoon
authors.initials: SH
authors.lastname: Lee
authors.forename: Na-Young
authors.initials: NY
authors.lastname: Yoon
authors.forename: Ji Hoe
authors.initials: JH
authors.lastname: Kim
authors.forename: Tae Hoon
authors.initials: TH
authors.lastname: Kim
authors.forename: Yong-Hyun
authors.initials: YH
authors.lastname: Chung
authors.forename: Seon-Bong
authors.initials: SB
authors.lastname: Kim
authors.forename: Young-Man
authors.initials: YM
authors.lastname: Kim
authors.forename: Hyun-Woo
authors.initials: HW
authors.lastname: Kim
authors.forename: Myung-Suk
authors.initials: MS
authors.lastname: Lee
authors.forename: Young-Mog
authors.initials: YM
authors.lastname: Kim
mesh_terms: D000667:Ampicillin / Q000494:pharmacology; D000818:Animals; D000900:Anti-Bacterial Agents / Q000302:isolation & purification / Q000494:pharmacology*; D001572:Benzofurans / Q000302:isolation & purification / Q000494:pharmacology*; D004147:Dioxins / Q000302:isolation & purification / Q000494:pharmacology*; D004357:Drug Synergism; D055624:Methicillin-Resistant Staphylococcus aureus / Q000187:drug effects*; D008826:Microbial Sensitivity Tests; D010068:Oxacillin / Q000494:pharmacology; D010406:Penicillins / Q000494:pharmacology; D000459:Phaeophyceae / Q000737:chemistry*; D013634:Tannins / Q000302:isolation & purification / Q000494:pharmacology*
chemical_list: D000900:Anti-Bacterial Agents; D001572:Benzofurans; D004147:Dioxins; D010406:Penicillins; D013634:Tannins; C064093:phlorofucofuroeckol A; D000667:Ampicillin; D010068:Oxacillin