title: Comb-shaped glycopolymer/peptide bioconjugates by combination of RAFT polymerization and thiol-ene "click" chemistry.
abstract: Comb-shaped glycopolymer/peptide bioconjugates are constructed by grafting reduced glutathione (GSH) onto acrylate-functional block glycocopolymers via thiol-ene click chemistry. In aqueous solution, the glycopolymer/GSH bioconjugate self-assembles to sugar-installed spherical micelles. The size of micelles decreases with increasing pH, demonstrating pH-responsive character. The isoelectric point (IEP) of the PMAGlc/GSH bioconjugate is estimated to be 3.43. The micelles show a specific interaction with the protein Concanavalin A. At endosomal pH, the PMAGlc/GSH bioconjugate can gradually degrade. These pH-responsive glycopolymer/peptide micelles with biological recognition and degradation can be used as multifunctional nanocarriers for targeted drug delivery.
authors.affiliation: Key Laboratory of Functional Polymer Materials, Ministry of Education, Institute of Polymer Chemistry, Nankai University, Tianjin 300071, China.
authors.forename: Xiaobei
authors.initials: X
authors.lastname: Wang
authors.forename: Li
authors.initials: L
authors.lastname: Liu
authors.forename: Yan
authors.initials: Y
authors.lastname: Luo
authors.forename: Haiting
authors.initials: H
authors.lastname: Shi
authors.forename: Jingyi
authors.initials: J
authors.lastname: Li
authors.forename: Hanying
authors.initials: H
authors.lastname: Zhao
mesh_terms: D000179:Acrylates / Q000737:chemistry*; D057930:Click Chemistry; D003208:Concanavalin A / Q000032:analysis / Q000737:chemistry*; D004337:Drug Carriers / Q000138:chemical synthesis*; D005978:Glutathione / Q000737:chemistry*; D006001:Glycoconjugates / Q000138:chemical synthesis*; D006863:Hydrogen-Ion Concentration; D007526:Isoelectric Point; D009682:Magnetic Resonance Spectroscopy; D008823:Micelles; D046529:Microscopy, Electron, Transmission; D010455:Peptides / Q000737:chemistry*; D058105:Polymerization; D013438:Sulfhydryl Compounds / Q000737:chemistry*
chemical_list: D000179:Acrylates; D004337:Drug Carriers; D006001:Glycoconjugates; D008823:Micelles; D010455:Peptides; D013438:Sulfhydryl Compounds; D003208:Concanavalin A; D005978:Glutathione; C036658:acrylic acid