title: Increase of complement fragment C5a in cerebrospinal fluid during exacerbation of neuromyelitis optica.
abstract: Complement is thought to play a pivotal role in neuromyelitis optica (NMO) pathogenesis. Anaphylatoxins (C3a, C4a, and C5a), produced in complement activation, have proinflammatory potential, and thereby may play an important role. We measured concentrations of anaphylatoxins in CSF and sera, obtained from patients with NMO (n=15), multiple sclerosis (MS) (n=15), and other neurological disease (OND) (n=12), and evaluated their clinical implications. The CSF-C5a levels were elevated significantly in NMO patients, especially in patients with multiple enhanced lesions on MRI. The CSF-C5a levels correlated with the severity of exacerbation. Our results may provide a rationale for anti-complement therapies of NMO.
authors.affiliation: Department of Neurology, Tohoku University Graduate School of Medicine, Aobaku, Sendai, Japan. dakuro@med.tohoku.ac.jp
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Kuroda
authors.forename: Kazuo
authors.initials: K
authors.lastname: Fujihara
authors.forename: Rina
authors.initials: R
authors.lastname: Takano
authors.forename: Yoshiki
authors.initials: Y
authors.lastname: Takai
authors.forename: Toshiyuki
authors.initials: T
authors.lastname: Takahashi
authors.forename: Tatsuro
authors.initials: T
authors.lastname: Misu
authors.forename: Ichiro
authors.initials: I
authors.lastname: Nakashima
authors.forename: Shigeru
authors.initials: S
authors.lastname: Sato
authors.forename: Yasuto
authors.initials: Y
authors.lastname: Itoyama
authors.forename: Masashi
authors.initials: M
authors.lastname: Aoki
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001921:Brain / Q000473:pathology; D015936:Complement C5a / Q000134:cerebrospinal fluid*; D005260:Female; D006801:Humans; D016014:Linear Models; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000134:cerebrospinal fluid / Q000473:pathology; D009422:Nervous System Diseases / Q000134:cerebrospinal fluid / Q000473:pathology; D009471:Neuromyelitis Optica / Q000134:cerebrospinal fluid* / Q000473:pathology; D012720:Severity of Illness Index; D055815:Young Adult
chemical_list: D015936:Complement C5a