title: Functional roles for myosin 1c in cellular signaling pathways.
abstract: Cellular signaling pathways underlie the transfer of information throughout the cell and to adjoining cells and so govern most critical cellular functions. Increasing evidence points to the molecular motor myosin 1c as a prominent player in many signaling cascades, from the integrin-dependent signaling involved in cell migration to the signaling events underlying insulin resistance. Myosin 1c functions on these pathways both via an important role in regulating lipid raft recycling and also via direct involvement in signaling cascades. This review provides an overview of the functional involvement of myosin 1c in cellular signaling and discusses the possible potential for myosin 1c as a target for drug-based treatments for human diseases.
authors.affiliation: Cambridge Institute for Medical Research, University of Cambridge, Wellcome Trust/MRC Building, Hills Road, Cambridge, CB2 0XY, United Kingdom.
authors.forename: Lisa M
authors.initials: LM
authors.lastname: Bond
authors.forename: Hemma
authors.initials: H
authors.lastname: Brandstaetter
authors.forename: John
authors.initials: J
authors.lastname: Kendrick-Jones
authors.forename: Folma
authors.initials: F
authors.lastname: Buss
mesh_terms: D006801:Humans; D007328:Insulin / Q000378:metabolism; D007333:Insulin Resistance; D016023:Integrins / Q000378:metabolism; D021962:Membrane Microdomains / Q000378:metabolism; D008565:Membrane Proteins / Q000378:metabolism; D009218:Myosins / Q000378:metabolism*; D015398:Signal Transduction; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism
chemical_list: D007328:Insulin; D016023:Integrins; C431137:KIRREL1 protein, human; D008565:Membrane Proteins; D014409:Tumor Necrosis Factor-alpha; D009218:Myosins