title: Total synthesis of the initially reported and revised structures of the neuroprotective agent palmyrolide A.
abstract: The total syntheses of the initially reported and revised structures of the neuroprotective agent palmyrolide A are reported. The key macrocyclization step was achieved using a sequential ring closing metathesis/olefin isomerization reaction. The synthetic work described herein serves to confirm the recent structural revision of this unusual natural product.
authors.affiliation: School of Chemical Sciences, The University of Auckland, 23 Symonds Street, Auckland, 1010, New Zealand.
authors.forename: Andrew D
authors.initials: AD
authors.lastname: Wadsworth
authors.forename: Daniel P
authors.initials: DP
authors.lastname: Furkert
authors.forename: Jonathan
authors.initials: J
authors.lastname: Sperry
authors.forename: Margaret A
authors.initials: MA
authors.lastname: Brimble
mesh_terms: D003500:Cyclization; D018942:Macrolides / Q000138:chemical synthesis*; D015394:Molecular Structure
chemical_list: D018942:Macrolides; C572829:palmyrolide A