title: Distribution and dynamics of transcription-associated proteins during parvovirus infection.
abstract: Canine parvovirus (CPV) infection leads to reorganization of nuclear proteinaceous subcompartments. Our studies showed that virus infection causes a time-dependent increase in the amount of viral nonstructural protein NS1 mRNA. Fluorescence recovery after photobleaching showed that the recovery kinetics of nuclear transcription-associated proteins, TATA binding protein (TBP), transcription factor IIB (TFIIB), and poly(A) binding protein nuclear 1 (PABPN1) were different in infected and noninfected cells, pointing to virus-induced alterations in binding dynamics of these proteins.
authors.affiliation: Nanoscience Center, Department of Biological and Environmental Science, University of Jyväskylä, Finland.
authors.forename: Teemu O
authors.initials: TO
authors.lastname: Ihalainen
authors.forename: Sami F
authors.initials: SF
authors.lastname: Willman
authors.forename: Einari A
authors.initials: EA
authors.lastname: Niskanen
authors.forename: Outi
authors.initials: O
authors.lastname: Paloheimo
authors.forename: Hanna
authors.initials: H
authors.lastname: Smolander
authors.forename: Juha P
authors.initials: JP
authors.lastname: Laurila
authors.forename: Minna U
authors.initials: MU
authors.lastname: Kaikkonen
authors.forename: Maija
authors.initials: M
authors.lastname: Vihinen-Ranta
mesh_terms: D000818:Animals; D002451:Cell Compartmentation; D010322:Parvoviridae Infections / Q000378:metabolism*; D017993:Parvovirus, Canine / Q000302:isolation & purification; D013347:Subcellular Fractions / Q000378:metabolism*; D014157:Transcription Factors / Q000378:metabolism*
chemical_list: D014157:Transcription Factors