title: Capecitabine-induced hypertriglyceridemia and hyperglycemia: two cases.
abstract: Capecitabine has shown significant antitumor activity against anthracycline/taxane refractory breast cancer and advanced colorectal carcinoma. The main drug-related adverse effects are palmar-plantar erythrodysesthesia (hand-foot syndrome), diarrhea and stomatitis. Dyslipidemia is a rare but important side effect of this drug. The mechanism of capecitabine-induced hypertriglyceridemia (CI-HTG) is unclear. It may be due to the decreased activities of lipoprotein lipase and hepatic triglyceride lipase. This report is associated with 2 patients who developed severe HTG when receiving capecitabine. Capecitabine was discountinued and antilipemic treatments were given and both cases are in follow-up with normal lipid levels. This report describes CI-HTG and possible pathogenetic mechanisms and the literature is reviewed.
authors.affiliation: Cukurova University Medical Faculty Departments of Medical Oncology, Balcalı Hospital, Adana, Turkey. berboz@hotmail.com
authors.forename: Berna Bozkurt
authors.initials: BB
authors.lastname: Duman
authors.forename: Semra
authors.initials: S
authors.lastname: Paydas
authors.forename: Tamer
authors.initials: T
authors.lastname: Tetiker
authors.forename: Meral
authors.initials: M
authors.lastname: Gunaldı
authors.forename: Cigdem Usul
authors.initials: CU
authors.lastname: Afsar
authors.forename: Vehbi
authors.initials: V
authors.lastname: Erçolak
authors.forename: Veysel
authors.initials: V
authors.lastname: Haksöyler
authors.forename: Merve Şimşek
authors.initials: MŞ
authors.lastname: Dilli
mesh_terms: D000964:Antimetabolites, Antineoplastic / Q000009:adverse effects*; D000069287:Capecitabine; D003841:Deoxycytidine / Q000009:adverse effects / Q000031:analogs & derivatives*; D005260:Female; D005472:Fluorouracil / Q000009:adverse effects / Q000031:analogs & derivatives*; D006801:Humans; D006943:Hyperglycemia / Q000139:chemically induced*; D015228:Hypertriglyceridemia / Q000139:chemically induced*; D008875:Middle Aged
chemical_list: D000964:Antimetabolites, Antineoplastic; D003841:Deoxycytidine; D000069287:Capecitabine; D005472:Fluorouracil