title: Diffusion tensor imaging atlas-based analyses in major depression after mild traumatic brain injury.
abstract: There are currently no known early neuroanatomical markers predictive of the development of major depression or depressive symptoms after mild traumatic brain injury (mTBI). The authors conducted a 1-year longitudinal pilot study to determine whether diffusion tensor imaging (DTI) measures collected within 1 month of mTBI could predict incident depression. Of the 14 subjects who met study inclusion criteria, 4 (28.6%) developed major depression over the follow-up period. Compared with the nondepressed group, those who developed depression had white-matter abnormalities in the fronto-temporal regions measured by DTI. These preliminary results highlight the need for additional studies, including studies using a larger sample and appropriate controls.
authors.affiliation: Department of Psychiatry, Johns Hopkins School of Medicine, Baltimore, MD, USA. vrao@jhmi.edu
authors.forename: Vani
authors.initials: V
authors.lastname: Rao
authors.forename: Michelle
authors.initials: M
authors.lastname: Mielke
authors.forename: Xin
authors.initials: X
authors.lastname: Xu
authors.forename: Gwenn S
authors.initials: GS
authors.lastname: Smith
authors.forename: Una D
authors.initials: UD
authors.lastname: McCann
authors.forename: Alyssa
authors.initials: A
authors.lastname: Bergey
authors.forename: Vishal
authors.initials: V
authors.lastname: Doshi
authors.forename: Dzung L
authors.initials: DL
authors.lastname: Pham
authors.forename: David
authors.initials: D
authors.lastname: Yousem
authors.forename: Susumi
authors.initials: S
authors.lastname: Mori
mesh_terms: D000328:Adult; D016880:Anisotropy; D001921:Brain / Q000473:pathology*; D001930:Brain Injuries / Q000150:complications*; D003865:Major Depressive Disorder / Q000175:diagnosis* / Q000209:etiology*; D056324:Diffusion Tensor Imaging; D005260:Female; D005500:Follow-Up Studies; D015600:Glasgow Coma Scale; D006801:Humans; D007091:Image Processing, Computer-Assisted; D016014:Linear Models; D008297:Male; D008875:Middle Aged; D011569:Psychiatric Status Rating Scales; D055815:Young Adult