title: Predictive factors associated with change rates of LV hypertrophy and renal dysfunction in CKD patients.
abstract: BACKGROUND
  This longitudinal study is the first report on the factors associated with change rates of the estimated glomerular filtration rate (eGFR) and left ventricular mass index (LVMI) using echocardiography in chronic kidney disease (CKD) patients.
  
  
  METHODS
  Measurements of biochemical and physical values, and LVMI evaluated by echocardiography were performed twice (baseline and follow-up period) in pre-dialysis CKD patients. Blood and urine samples were collected at the time of the echocardiographic study.
  
  
  RESULTS
  The change rates of hemoglobin (Hb) and transferrin saturation (TSAT: (serum iron/total iron binding capacity)) were identified as independent risk factors for changes in eGFR by multivariate regression analysis. In the LVMI improvement group, the change rate of systolic blood pressure (sBP) was identified as an independent factor for change in LVMI. In the LVMI worsening group, the change rates of sBP, proteinuria and Hb were identified as independent risk factors for changes in LVMI.
  
  
  CONCLUSIONS
  It appears that treatment of renal and iron deficiency anemia might prevent progression of renal dysfunction. To prevent LV hypertrophy in CKD patients, renal anemia, hypertension and proteinuria should be treated.
authors.affiliation: Department of Internal Medicine, Juntendo University, Tokyo, Japan.
authors.forename: Kozue
authors.initials: K
authors.lastname: Okumura
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Io
authors.forename: Mayumi
authors.initials: M
authors.lastname: Matsumoto
authors.forename: Takuya
authors.initials: T
authors.lastname: Seto
authors.forename: Miyuki
authors.initials: M
authors.lastname: Takagi
authors.forename: Atsumi
authors.initials: A
authors.lastname: Masuda
authors.forename: Masako
authors.initials: M
authors.lastname: Furukawa
authors.forename: Lili
authors.initials: L
authors.lastname: Nagahama
authors.forename: Keisuke
authors.initials: K
authors.lastname: Omote
authors.forename: Atsuko
authors.initials: A
authors.lastname: Hisada
authors.forename: Chieko
authors.initials: C
authors.lastname: Hamada
authors.forename: Satoshi
authors.initials: S
authors.lastname: Horikoshi
authors.forename: Yasuhiko
authors.initials: Y
authors.lastname: Tomino
mesh_terms: D001794:Blood Pressure; D018450:Disease Progression; D004452:Echocardiography; D005260:Female; D005500:Follow-Up Studies; D005919:Glomerular Filtration Rate / Q000502:physiology*; D006801:Humans; D017379:Hypertrophy, Left Ventricular / Q000453:epidemiology* / Q000209:etiology / Q000503:physiopathology; D015994:Incidence; D007564:Japan / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D051436:Renal Insufficiency, Chronic / Q000150:complications* / Q000503:physiopathology; D012189:Retrospective Studies; D012307:Risk Factors