title: Structure formation and hydrogen bonding in all-aliphatic segmented copolymers with uniform hard segments.
abstract: Fully aliphatic segmented poly(ether ester amide) copolymers with uniform hard segments prepared by melt polycondensation of α,ω-hydroxyl end-functionalized polytetrahydrofuran and short glycine or β-alanine bisester-bisoxalamide units hold promise for biomedical applications. For polymers with the hard block contents varying from 10% to 27%, differential scanning calorimetry and atomic force microscopy reveal a highly phase-separated morphology, with ribbon-like nanocrystals dispersed in the soft segment matrix. To relate the polymer properties to the structure of the hard segment, the monomers were prepared and studied by optical and X-ray diffraction measurements. It was shown that the glycine and β-alanine carbonyl ester groups are tilted away from the oxalamide plane, which can affect the degradation rate via hydrolysis of the ester bond.
authors.affiliation: Institut de Sciences des Matériaux de Mulhouse-IS2M, CNRS LRC 7228, Mulhouse, France.
authors.forename: Ya I
authors.initials: YI
authors.lastname: Odarchenko
authors.forename: N J
authors.initials: NJ
authors.lastname: Sijbrandi
authors.forename: M
authors.initials: M
authors.lastname: Rosenthal
authors.forename: A J
authors.initials: AJ
authors.lastname: Kimenai
authors.forename: E P C
authors.initials: EP
authors.lastname: Mes
authors.forename: R
authors.initials: R
authors.lastname: Broos
authors.forename: G
authors.initials: G
authors.lastname: Bar
authors.forename: P J
authors.initials: PJ
authors.lastname: Dijkstra
authors.forename: J
authors.initials: J
authors.lastname: Feijen
authors.forename: D A
authors.initials: DA
authors.lastname: Ivanov
mesh_terms: D001672:Biocompatible Materials / Q000737:chemistry*; D002244:Carbon / Q000737:chemistry*; D004951:Esterification; D006244:Hardness; D006860:Hydrogen Bonding; D006868:Hydrolysis; D008422:Materials Testing; D053758:Nanoparticles / Q000737:chemistry* / Q000648:ultrastructure*; D009930:Organic Chemicals / Q000737:chemistry*; D011108:Polymers / Q000737:chemistry*
chemical_list: D001672:Biocompatible Materials; D009930:Organic Chemicals; D011108:Polymers; D002244:Carbon