title: NMR of hyperpolarised probes.
abstract: Increasing the sensitivity of NMR experiments is an ongoing field of research to help realise the exquisite molecular specificity of this technique. Hyperpolarisation of various nuclei is a powerful approach that enables the use of NMR for molecular and cellular imaging. Substantial progress has been achieved over recent years in terms of both tracer preparation and detection schemes. This review summarises recent developments in probe design and optimised signal encoding, and promising results in sensitive disease detection and efficient therapeutic monitoring. The different methods have great potential to provide molecular specificity not available by other diagnostic modalities.
authors.affiliation: ERC Project BiosensorImaging, Leibniz-Institut für Molekulare Pharmakologie, Berlin, Germany.
authors.forename: Christopher
authors.initials: C
authors.lastname: Witte
authors.forename: Leif
authors.initials: L
authors.lastname: Schröder
mesh_terms: D000818:Animals; D002247:Carbon Isotopes; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D015335:Molecular Probes / Q000737:chemistry*; D012815:Signal Processing, Computer-Assisted
chemical_list: D002247:Carbon Isotopes; D015335:Molecular Probes