title: Anti-aquaporin-4 IgG in Patients Presenting with Unilateral Optic Neuritis: A Cohort Study.
abstract: BACKGROUND
  Optic neuritis (ON) can be the first presentation of multiple sclerosis (MS) or neuromyelitis optica (NMO). Anti-aquaporin-4 IgG (AQP4 IgG) is a highly specific and moderately sensitive biomarker for NMO. This study was designed to assess the rate of seropositivity for AQP4 IgG, and the short-term outcome of patients presenting with single isolated ON (SION).
  
  
  METHODS
  A cohort of 41 consecutive patients experiencing severe (< 20 / 200) SION (not fulfilling the diagnostic criteria for MS or NMO), was prospectively recruited. Blood sampling was carried out immediately after the diagnosis of ON, and AQP4 IgG was tested qualitatively, using an indirect immunofluorescence kit. After clinical and paraclinical investigations, all the patients were followed up for a short-term period of at least 18 months.
  
  
  RESULTS
  The seroprevalence among the initial ON patients was 9.7% (4 / 41). The short-term conversion rate to MS and NMO was estimated to be about 7.3 and 4.9%, respectively. The conversion rate to NMO in initially seropositive patients was greater than that for the whole cohort [2 / 4 (50%) vs. 2 / 41 (4.9%); P = 0.035; Odds ratio: 19.5, 95% confidence interval: 1.73 to 219.50].
  
  
  CONCLUSIONS
  AQP4 IgG seropositive SION patients were more likely to develop NMO in comparison to the total SION population. Further studies, with a longer follow-up period and larger sample sizes are warranted to assess the clinical and prognostic value of assessing AQP4 IgG in SION.
authors.affiliation: Isfahan Research Committee of Multiple Sclerosis (IRCOMS), Isfahan, Iran, ; Medical School, Isfahan University of Medical Sciences, Isfahan, Iran.
authors.forename: Masoud
authors.initials: M
authors.lastname: Etemadifar
authors.forename: Mohammad-Ali
authors.initials: MA
authors.lastname: Abtahi
authors.forename: Hassan
authors.initials: H
authors.lastname: Razmjoo
authors.forename: Seyed-Hossein
authors.initials: SH
authors.lastname: Abtahi
authors.forename: Ali-Reza
authors.initials: AR
authors.lastname: Dehghani
authors.forename: Zahra-Alsadat
authors.initials: ZA
authors.lastname: Abtahi
authors.forename: Mojtaba
authors.initials: M
authors.lastname: Akbari
authors.forename: Shahir
authors.initials: S
authors.lastname: Mazaheri
authors.forename: Amir-Hadi
authors.initials: AH
authors.lastname: Maghzi