title: Chapter seven--Cancer treatment with gene therapy and radiation therapy.
abstract: Radiation therapy methods have evolved remarkably in recent years which have resulted in more effective local tumor control with negligible toxicity of surrounding normal tissues. However, local recurrence and distant metastasis often occur following radiation therapy mostly due to the development of radioresistance through the deregulation of the cell cycle, apoptosis, and inhibition of DNA damage repair mechanisms. Over the last decade, extensive progress in radiotherapy and gene therapy combinatorial approaches has been achieved to overcome resistance of tumor cells to radiation. In this review, we summarize the results from experimental cancer therapy studies on the combination of radiation therapy and gene therapy.
authors.affiliation: Department of Radiation Oncology, Washington University in St Louis, St Louis, Missouri, USA. donald.buchsbaum@ccc.uab.edu
authors.forename: Sergey A
authors.initials: SA
authors.lastname: Kaliberov
authors.forename: Donald J
authors.initials: DJ
authors.lastname: Buchsbaum
mesh_terms: D000818:Animals; D017209:Apoptosis; D002986:Clinical Trials as Topic; D003131:Combined Modality Therapy / Q000379:methods*; D004260:DNA Repair; D018014:Gene Transfer Techniques; D015316:Genetic Therapy / Q000379:methods*; D006801:Humans; D008495:Medical Oncology / Q000639:trends; D009369:Neoplasms / Q000235:genetics* / Q000532:radiotherapy* / Q000628:therapy*; D011401:Promoter Regions, Genetic; D011878:Radiotherapy / Q000379:methods*; D020218:Response Elements; D015398:Signal Transduction