title: Prospective study of particulate air pollution exposures, subclinical atherosclerosis, and clinical cardiovascular disease: The Multi-Ethnic Study of Atherosclerosis and Air Pollution (MESA Air).
abstract: The Multi-Ethnic Study of Atherosclerosis and Air Pollution (MESA Air) was initiated in 2004 to investigate the relation between individual-level estimates of long-term air pollution exposure and the progression of subclinical atherosclerosis and the incidence of cardiovascular disease (CVD). MESA Air builds on a multicenter, community-based US study of CVD, supplementing that study with additional participants, outcome measurements, and state-of-the-art air pollution exposure assessments of fine particulate matter, oxides of nitrogen, and black carbon. More than 7,000 participants aged 45-84 years are being followed for over 10 years for the identification and characterization of CVD events, including acute myocardial infarction and other coronary artery disease, stroke, peripheral artery disease, and congestive heart failure; cardiac procedures; and mortality. Subcohorts undergo baseline and follow-up measurements of coronary artery calcium using computed tomography and carotid artery intima-medial wall thickness using ultrasonography. This cohort provides vast exposure heterogeneity in ranges currently experienced and permitted in most developed nations, and the air monitoring and modeling methods employed will provide individual estimates of exposure that incorporate residence-specific infiltration characteristics and participant-specific time-activity patterns. The overarching study aim is to understand and reduce uncertainty in health effect estimation regarding long-term exposure to air pollution and CVD.
authors.affiliation: Department of Environmental and Occupational Health Sciences, School of Public Health, University of Washington, Seattle, USA. joel@u.washington.edu
authors.forename: Joel D
authors.initials: JD
authors.lastname: Kaufman
authors.forename: Sara D
authors.initials: SD
authors.lastname: Adar
authors.forename: Ryan W
authors.initials: RW
authors.lastname: Allen
authors.forename: R Graham
authors.initials: RG
authors.lastname: Barr
authors.forename: Matthew J
authors.initials: MJ
authors.lastname: Budoff
authors.forename: Gregory L
authors.initials: GL
authors.lastname: Burke
authors.forename: Adrian M
authors.initials: AM
authors.lastname: Casillas
authors.forename: Martin A
authors.initials: MA
authors.lastname: Cohen
authors.forename: Cynthia L
authors.initials: CL
authors.lastname: Curl
authors.forename: Martha L
authors.initials: ML
authors.lastname: Daviglus
authors.forename: Ana V
authors.initials: AV
authors.lastname: Diez Roux
authors.forename: David R
authors.initials: DR
authors.lastname: Jacobs
authors.forename: Richard A
authors.initials: RA
authors.lastname: Kronmal
authors.forename: Timothy V
authors.initials: TV
authors.lastname: Larson
authors.forename: Sally Lee-Jane
authors.initials: SL
authors.lastname: Liu
authors.forename: Thomas
authors.initials: T
authors.lastname: Lumley
authors.forename: Ana
authors.initials: A
authors.lastname: Navas-Acien
authors.forename: Daniel H
authors.initials: DH
authors.lastname: O'Leary
authors.forename: Jerome I
authors.initials: JI
authors.lastname: Rotter
authors.forename: Paul D
authors.initials: PD
authors.lastname: Sampson
authors.forename: Lianne
authors.initials: L
authors.lastname: Sheppard
authors.forename: David S
authors.initials: DS
authors.lastname: Siscovick
authors.forename: James H
authors.initials: JH
authors.lastname: Stein
authors.forename: Adam A
authors.initials: AA
authors.lastname: Szpiro
authors.forename: Russell P
authors.initials: RP
authors.lastname: Tracy
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000393:Air Pollutants / Q000032:analysis / Q000633:toxicity*; D000397:Air Pollution / Q000009:adverse effects* / Q000032:analysis / Q000706:statistics & numerical data; D050197:Atherosclerosis / Q000139:chemically induced / Q000453:epidemiology*; D002318:Cardiovascular Diseases / Q000139:chemically induced / Q000453:epidemiology*; D059168:Carotid Intima-Media Thickness; D004781:Environmental Exposure / Q000009:adverse effects* / Q000032:analysis; D005260:Female; D006304:Health Status; D006801:Humans; D015994:Incidence; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D009589:Nitrogen Oxides / Q000032:analysis / Q000633:toxicity; D052638:Particulate Matter / Q000032:analysis / Q000633:toxicity*; D011446:Prospective Studies; D012307:Risk Factors; D012907:Smoking / Q000453:epidemiology; D012959:Socioeconomic Factors; D053260:Soot / Q000032:analysis / Q000633:toxicity; D013997:Time Factors; D014057:Tomography, X-Ray Computed; D014481:United States / Q000453:epidemiology
chemical_list: D000393:Air Pollutants; D009589:Nitrogen Oxides; D052638:Particulate Matter; D053260:Soot