title: Active surveillance of postmarket medical product safety in the Federal Partners' Collaboration.
abstract: After half a century of monitoring voluntary reports of medical product adverse events, the Food and Drug Administration (FDA) has launched a long-term project to build an adverse events monitoring system, the Sentinel System, which can access and evaluate electronic health care data to help monitor the safety of regulated medical products once they are marketed. On the basis of experience gathered through a number of collaborative efforts, the Federal Partners' Collaboration pilot project, involving FDA, the Centers for Medicare & Medicaid Services, the Department of Veteran Affairs, and the Department of Defense, is already enabling FDA to leverage the power of large public health care databases to assess, in near real time, the utility of analytical tools and methodologies that are being developed for use in the Sentinel System. Active medical product safety surveillance is enhanced by use of these large public health databases because specific populations of exposed patients can be identified and analyzed, and can be further stratified by key variables such as age, sex, race, socioeconomic status, and basis for eligibility to examine important subgroups.
authors.affiliation: Office of Medical Policy, Center for Drug Evaluation and Research, Food and Drug Administration, 10903 New Hampshire Ave, Building 51, Room 6360, Silver Spring, MD 20993, USA. melissa.robb@fda.hhs.gov
authors.forename: Melissa A
authors.initials: MA
authors.lastname: Robb
authors.forename: Judith A
authors.initials: JA
authors.lastname: Racoosin
authors.forename: Chris
authors.initials: C
authors.lastname: Worrall
authors.forename: Summer
authors.initials: S
authors.lastname: Chapman
authors.forename: Trinka
authors.initials: T
authors.lastname: Coster
authors.forename: Francesca E
authors.initials: FE
authors.lastname: Cunningham
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D000998:Antiviral Agents / Q000008:administration & dosage / Q000009:adverse effects; D014487:Centers for Medicare and Medicaid Services, U.S. / Q000458:organization & administration; D016208:Databases, Factual; D005260:Female; D006801:Humans; D007256:Information Systems / Q000458:organization & administration*; D007373:Interinstitutional Relations; D008297:Male; D008875:Middle Aged; D010865:Pilot Projects; D011358:Product Surveillance, Postmarketing / Q000379:methods*; D012737:Sex Factors; D012959:Socioeconomic Factors; D014481:United States; D059030:United States Department of Defense / Q000458:organization & administration; D014493:United States Department of Veterans Affairs / Q000458:organization & administration; D014486:United States Food and Drug Administration / Q000458:organization & administration*; D055815:Young Adult
chemical_list: D000998:Antiviral Agents