title: Incorporation of penicillin-producing fungi into living materials to provide chemically active and antibiotic-releasing surfaces.
abstract: Living materials: artificial biological niches are loaded with the penicillin-producing mold Penicillium chrysogenum. This living material consumes food through a nanoporous top layer and releases the antibiotic on-site. No reloading of the active compound is needed. Gram-positive bacteria were efficiently killed if nearby, whereas Gram-negative bacteria (control experiment, not sensitive to penicillin) were not affected.
authors.affiliation: Department of Chemistry and Applied Biosciences, ETH Zurich, Switzerland.
authors.forename: Lukas C
authors.initials: LC
authors.lastname: Gerber
authors.forename: Fabian M
authors.initials: FM
authors.lastname: Koehler
authors.forename: Robert N
authors.initials: RN
authors.lastname: Grass
authors.forename: Wendelin J
authors.initials: WJ
authors.lastname: Stark
mesh_terms: D040761:Biomimetic Materials / Q000378:metabolism; D005658:Fungi / Q000235:genetics / Q000254:growth & development* / Q000378:metabolism*; D008826:Microbial Sensitivity Tests; D009172:Mycology / Q000379:methods; D010406:Penicillins / Q000096:biosynthesis* / Q000494:pharmacology; D010407:Penicillium / Q000254:growth & development / Q000378:metabolism*
chemical_list: D010406:Penicillins