title: A rat's whiskers point the way toward a novel stimulus-dependent, protective stroke therapy.
abstract: Stroke is the fourth leading cause of death in the United States and the leading cause of long-term disability. Ischemic stroke, due to an interruption in blood supply, is particularly prevalent; 87% of all strokes are ischemic. Unfortunately, current options for acute treatment are extremely limited and there is a great need for new treatment strategies. This review will discuss evidence that mild sensory stimulation can completely protect the jeopardized brain from an impending stroke in a rodent model. When delivered within the first 2 hours following ischemic onset, this stimulation results in complete protection, including a full reestablishment of cortical function, sensorimotor capabilities, and blood flow. Identical stimulation, however, initiated 3 hours following ischemic onset, results in an increase in damage compared with untreated animals. The protective effect is not specific to a single sensory modality, anesthesia, or age, and increasing evoked cortical activity by increasing stimulation accelerates recovery. Taken together, these findings demonstrate that cortical activity is a critical factor for protection and suggest a new, exciting potential avenue for the development of acute stroke treatment strategies that may produce a noninvasive, drug-free, equipment-free, and side effect-free means of protecting from ischemic stroke.
authors.affiliation: Department of Neurobiology and Behavior, University of California, Irvine, Irvine, CA 92697, USA. rfrostig@uci.edu
authors.forename: Ron D
authors.initials: RD
authors.lastname: Frostig
authors.forename: Christopher C
authors.initials: CC
authors.lastname: Lay
authors.forename: Melissa F
authors.initials: MF
authors.lastname: Davis
mesh_terms: D000344:Afferent Pathways / Q000502:physiology*; D000818:Animals; D001921:Brain / Q000098:blood supply / Q000503:physiopathology; D004195:Disease Models, Animal; D006801:Humans; D017063:Outcome Assessment, Health Care; D010812:Physical Stimulation / Q000379:methods*; D051381:Rats; D020521:Stroke / Q000175:diagnosis / Q000517:prevention & control*; D013997:Time Factors; D016896:Treatment Outcome; D014738:Vibrissae / Q000294:innervation / Q000502:physiology*