title: Microsatellite-based genotyping of Candida parapsilosis sensu stricto isolates reveals dominance and persistence of a particular epidemiological clone among neonatal intensive care unit patients.
abstract: In this study, using multilocus microsatellite analysis, we report the genetic characterization of 27 Candida parapsilosis isolates recovered in two different periods of time (2007-2009 and 2011-2012) from infants hospitalized in the neonatal intensive care unit of a hospital in Messina, Italy. The results revealed the persistence and dominance of a particular infectious genotype among NICU patients and highlight the power of the used microsatellite markers in clarifying epidemiologic associations, detect micro-evolutionary variations and facilitating the recognition of outbreaks.
authors.affiliation: Department of Life Sciences Marcello Malpighi - Section of Microbiological, Genetic and Molecular Sciences - University of Messina, Viale F. Stagno d'Alcontres, 31 - 98166 Messina, Italy. oromeo@unime.it
authors.forename: Orazio
authors.initials: O
authors.lastname: Romeo
authors.forename: Demetrio
authors.initials: D
authors.lastname: Delfino
authors.forename: Antonio
authors.initials: A
authors.lastname: Cascio
authors.forename: Carla
authors.initials: C
authors.lastname: Lo Passo
authors.forename: Maria
authors.initials: M
authors.lastname: Amorini
authors.forename: Daniela
authors.initials: D
authors.lastname: Romeo
authors.forename: Ida
authors.initials: I
authors.lastname: Pernice
mesh_terms: D002175:Candida / Q000235:genetics* / Q000302:isolation & purification; D002177:Candidiasis / Q000453:epidemiology / Q000382:microbiology; D003428:Cross Infection / Q000453:epidemiology / Q000382:microbiology; D004196:Disease Outbreaks; D005838:Genotype; D006801:Humans; D007231:Infant, Newborn; D007363:Intensive Care Units, Neonatal; D018895:Microsatellite Repeats; D058885:Multilocus Sequence Typing