title: Associations between interleukin-1 gene polymorphisms and coronary heart disease risk: a meta-analysis.
abstract: OBJECTIVE
  A great number of studies regarding the associations between IL-1B-511, IL-1B+3954 and IL-1RN VNTR polymorphisms within the IL-1gene cluster and coronary heart disease (CHD) have been published. However, results have been inconsistent. In this study, a meta-analysis was performed to investigate the associations.
  
  
  METHODS
  Published literature from PubMed and Embase databases were searched for eligible publications. Pooled odds ratios (ORs) with 95% confidence intervals (CIs) were calculated using random- or fixed- effect model.
  
  
  RESULTS
  Thirteen studies (3,219 cases/2,445 controls) for IL-1B-511 polymorphism, nine studies (1,828 cases/1,818 controls) for IL-1B+3954 polymorphism and twelve studies (2,987 cases/ 2,208 controls) for IL-1RN VNTR polymorphism were included in this meta analysis. The results indicated that both IL-1B-511 and IL-1B+3954 polymorphisms were not associated with CHD risk (IL-1B-511 T vs. C: OR = 0.98, 95%CI 0.87-1.09; IL-1B+3954 T vs. C: OR = 1.06, 95%CI 0.95-1.19). Similarly, there was no association between IL-1RN VNTR polymorphism and CHD risk (*2 vs. L: OR = 1.00, 95%CI 0.85-1.17).
  
  
  CONCLUSIONS
  This meta-analysis suggested that there were no associations between IL-1 gene cluster polymorphisms and CHD.
authors.affiliation: Department of Sports Physiology, Hunan University of Science and Technology, Xiangtan, Hunan, China. liangzhou0731@163.com
authors.forename: Liang
authors.initials: L
authors.lastname: Zhou
authors.forename: Jianguang
authors.initials: J
authors.lastname: Cai
authors.forename: Gang
authors.initials: G
authors.lastname: Liu
authors.forename: Yuan
authors.initials: Y
authors.lastname: Wei
authors.forename: Hui
authors.initials: H
authors.lastname: Tang
mesh_terms: D003327:Coronary Disease / Q000235:genetics*; D018740:Genetic Heterogeneity; D020022:Genetic Predisposition to Disease; D006801:Humans; D007375:Interleukin-1 / Q000235:genetics*; D011110:Polymorphism, Genetic
chemical_list: D007375:Interleukin-1