title: Palladium-catalyzed synthesis of benzimidazoles and quinazolinones from common precursors.
abstract: N-(o-Halophenyl)imidoyl chlorides and the corresponding imidates are easily prepared and can be utilized as complementary precursors for the synthesis of important heterocycles. The synthesis of N-substituted benzimidazoles was possible from the palladium-catalyzed reaction of both classes of substrate with a variety of N-nucleophiles. The use of the imidate precursor for the synthesis of N-substituted quinazolinones by incorporation of a palladium-catalyzed aminocarbonylation reaction has also been demonstrated. Both processes tolerate a wide range of functional groups.
authors.affiliation: Chemistry Research Laboratory, University of Oxford, 12 Mansfield Road, Oxford OX1 3TA, UK.
authors.forename: Jessie E R
authors.initials: JE
authors.lastname: Sadig
authors.forename: Radleigh
authors.initials: R
authors.lastname: Foster
authors.forename: Florian
authors.initials: F
authors.lastname: Wakenhut
authors.forename: Michael C
authors.initials: MC
authors.lastname: Willis
mesh_terms: D001562:Benzimidazoles / Q000138:chemical synthesis* / Q000737:chemistry; D002384:Catalysis; D015394:Molecular Structure; D010165:Palladium / Q000737:chemistry*; D052999:Quinazolinones / Q000138:chemical synthesis* / Q000737:chemistry; D013237:Stereoisomerism
chemical_list: D001562:Benzimidazoles; D052999:Quinazolinones; D010165:Palladium