title: Combined bead polymerization and Cinchona organocatalyst immobilization by thiol-ene addition.
abstract: In this work, we report an unusually concise immobilization of Cinchona organocatalysts using thiol-ene chemistry, in which catalyst immobilization and bead polymerization is combined in a single step. A solution of azo initiator, polyfunctional thiol, polyfunctional alkene and an unmodified Cinchona-derived organocatalyst in a solvent is suspended in water and copolymerized on heating by thiol-ene additions. The resultant spherical and gel-type polymer beads have been evaluated as organocatalysts in catalytic asymmetric transformations.
authors.affiliation: Department of Chemistry, University of Oslo, P.O. Box 1033 Blindern, NO-0315 Oslo, Norway.
authors.forename: Kim A
authors.initials: KA
authors.lastname: Fredriksen
authors.forename: Tor E
authors.initials: TE
authors.lastname: Kristensen
authors.forename: Tore
authors.initials: T
authors.lastname: Hansen