title: A vesicular variant of pseudoverrucous papules and nodules in the genital area of an incontinent 4-year-old.
abstract: Irritant contact dermatitis is a common cause of chronic vulvitis in patients wearing diapers and incontinence garments. In most cases the diagnosis is obvious; however, atypical presentations may mimic more serious dermatoses. We present a 4-year-old girl who presented at birth with cloacal atresia corrected surgically and resulting in chronic incontinence requiring full-time diapers. She presented with crops of herpetiform vesicles and bullae on a base that ranged from normal skin to severe erythema and oedema. A histological examination revealed a well-demarcated lesion showing a thickened epidermis with hyperkeratosis and parakeratosis, acanthosis and an abrupt transition to pallor of the upper half. Focal full thickness epidermis necrosis and small areas of spongiosis, acantholysis and apoptotic keratinocytes were seen. Immunofluorescence was negative. The lesions improved with the treatment of secondary infection and minimal topical therapy with an emollient only. This case represents an unusual vesicular variant of pseudoverrucous papules and nodules, which has been reported only once previously.
authors.affiliation: Northern Clinical School, University of Sydney, Royal North Shore Hospital, St Leonards, Australia.
authors.forename: Shreya
authors.initials: S
authors.lastname: Dixit
authors.forename: James P
authors.initials: JP
authors.lastname: Scurry
authors.forename: Gayle
authors.initials: G
authors.lastname: Fischer
mesh_terms: D002675:Child, Preschool; D003963:Diaper Rash / Q000209:etiology* / Q000628:therapy; D005260:Female; D006801:Humans; D012872:Skin Diseases, Vesiculobullous / Q000188:drug therapy / Q000209:etiology / Q000473:pathology*; D014549:Urinary Incontinence / Q000150:complications*; D014845:Vulvar Diseases / Q000188:drug therapy / Q000209:etiology / Q000473:pathology*