title: [Correlation between insulin resistance and endothelial dysfunction assessed by flow-mediated dilation].
abstract: Insulin resistance and endothelial dysfunction are major cardiovascular risk factors. The purpose of this study was to determine whether only patients with insulin resistance also have an alteration of endothelial function assessed by ultrasound flow-mediated (FMD). In a population of 165 patients, 30 subjects had only a family history of diabetes and/or sporadic findings of hypoglycemia, and they were assessed for FMD, the glucose and insulin curve. Of these 30 subjects, 20 patients had an alteration of the parameters measured and were related with 20 healthy patients. The study group and the control group showed a markedly significant statistical difference in the performance of the curve insulin, in the calculation of FMD and HOMA. FMD allows to study populations with no apparent cardiovascular risk and to monitor the effectiveness of possible endothelial protective therapy.
authors.affiliation: UO di UTIC e Cardiologia, Ospedale di Urbino, Asur2 Marche, Urbino. giu.dattilo@libero.it
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Dattilo
authors.forename: Annalisa
authors.initials: A
authors.lastname: Lamari
authors.forename: Sergio
authors.initials: S
authors.lastname: Crosca
authors.forename: Stefania
authors.initials: S
authors.lastname: Tavella
authors.forename: Paola
authors.initials: P
authors.lastname: Fugà
authors.forename: Alfredo
authors.initials: A
authors.lastname: Conti
authors.forename: Michele
authors.initials: M
authors.lastname: Scarano
authors.forename: Paolo
authors.initials: P
authors.lastname: Busacca
mesh_terms: D000328:Adult; D000465:Algorithms; D015415:Biomarkers / Q000097:blood; D001783:Blood Flow Velocity; D001786:Blood Glucose / Q000378:metabolism; D015992:Body Mass Index; D016022:Case-Control Studies; D003196:Computer Graphics; D003924:Diabetes Mellitus, Type 2 / Q000150:complications / Q000453:epidemiology; D004730:Endothelium, Vascular / Q000000981:diagnostic imaging* / Q000503:physiopathology*; D005260:Female; D006801:Humans; D007328:Insulin / Q000097:blood; D007333:Insulin Resistance; D007558:Italy / Q000453:epidemiology; D008297:Male; D024821:Metabolic Syndrome / Q000150:complications / Q000453:epidemiology; D008875:Middle Aged; D015203:Reproducibility of Results; D012307:Risk Factors; D018608:Ultrasonography, Doppler / Q000379:methods; D014664:Vasodilation
chemical_list: D015415:Biomarkers; D001786:Blood Glucose; D007328:Insulin