title: Recent development of small antimicrobial peptidomimetics.
abstract: Antimicrobial peptides (AMPs) hold promise to circumvent the emergence of drug resistance occurring in the treatment of bacteria using many conventional antibiotics. Antimicrobial peptidomimetics, which mimic bactericidal mechanisms of AMPs, may overcome the disadvantages of AMPs and become the new generation of antibiotic therapeutics. In this review, some recent examples in the development of antimicrobial peptidomimetics are highlighted. The potential of antimicrobial agents has been demonstrated for therapeutic uses. Meanwhile, perspectives on their further development and applications are also presented.
authors.affiliation: Department of Chemistry, University of South Florida, Tampa, FL 33620, USA.
authors.forename: Youhong
authors.initials: Y
authors.lastname: Niu
authors.forename: Rongsheng E
authors.initials: RE
authors.lastname: Wang
authors.forename: Haifan
authors.initials: H
authors.lastname: Wu
authors.forename: Jianfeng
authors.initials: J
authors.lastname: Cai
mesh_terms: D000818:Animals; D000890:Anti-Infective Agents / Q000737:chemistry* / Q000494:pharmacology* / Q000627:therapeutic use; D001419:Bacteria / Q000187:drug effects*; D001424:Bacterial Infections / Q000188:drug therapy*; D024881:Drug Resistance, Bacterial; D006801:Humans; D057786:Peptidomimetics / Q000737:chemistry* / Q000494:pharmacology* / Q000627:therapeutic use
chemical_list: D000890:Anti-Infective Agents; D057786:Peptidomimetics