title: Synthesis of ynone trifluoroborates toward functionalized pyrazoles.
abstract: The synthesis of a range of novel ynone trifluoroborates has been achieved, in a two-pot process from propargylic alcohols. These alkynes have been subsequently used in the formation of a range of pyrazole trifluoroborate salts via cyclization with hydrazines. The products are generated with high levels of regiocontrol and in excellent yields and represent versatile synthetic intermediates.
authors.affiliation: Department of Chemistry, University of Sheffield, Brook Hill, Sheffield, S3 7HF, United Kingdom.
authors.forename: James D
authors.initials: JD
authors.lastname: Kirkham
authors.forename: Steven J
authors.initials: SJ
authors.lastname: Edeson
authors.forename: Stephen
authors.initials: S
authors.lastname: Stokes
authors.forename: Joseph P A
authors.initials: JP
authors.lastname: Harrity
mesh_terms: D003500:Cyclization; D015394:Molecular Structure; D011720:Pyrazoles / Q000138:chemical synthesis*
chemical_list: D011720:Pyrazoles