title: Core-shell nanoparticles as prodrugs: possible cytotoxicological and biomedical impacts of batch-to-batch inconsistencies.
abstract: Numerous samples of magnetite@silica and magnetite@silica@silane core-shell nanoparticles, previously used as prodrugs, were prepared by an experienced chemist, using the same identical equipment and the same lots of reagents. Their surface analyses showed batch-to-batch chemical variations: no two batches were found to have the same surface chemistries, showing unexpected Si-O bond scission and amine oxidation. Because the preparations used reactions recognized to be mild, and bond scission and oxidation were never previously reported for similar reactions on larger surfaces, the Fe(3)O(4) nanoparticles that form the nanoparticle core appear to have acted as catalysts for these side reactions. The intended use of these nanoparticles, as drug carriers, is discussed in terms of cytotoxicological and biomedical consequences.
authors.affiliation: Department of Restorative Dentistry, University of Manitoba, Winnipeg, MB, Canada.
authors.forename: R
authors.initials: R
authors.lastname: França
authors.forename: X-F
authors.initials: XF
authors.lastname: Zhang
authors.forename: T
authors.initials: T
authors.lastname: Veres
authors.forename: L'H
authors.initials: L
authors.lastname: Yahia
authors.forename: E
authors.initials: E
authors.lastname: Sacher
mesh_terms: D004337:Drug Carriers / Q000737:chemistry* / Q000633:toxicity; D052203:Ferrosoferric Oxide / Q000737:chemistry* / Q000633:toxicity; D006801:Humans; D053758:Nanoparticles / Q000737:chemistry* / Q000648:ultrastructure; D010084:Oxidation-Reduction; D011355:Prodrugs / Q000737:chemistry* / Q000633:toxicity; D012821:Silanes / Q000737:chemistry* / Q000633:toxicity; D012822:Silicon Dioxide / Q000737:chemistry* / Q000633:toxicity; D013499:Surface Properties
chemical_list: D004337:Drug Carriers; D011355:Prodrugs; D012821:Silanes; D012822:Silicon Dioxide; D052203:Ferrosoferric Oxide