title: [Myeloproliferative disorders "Philadelphia negative" and JAK2V617F mutation: study of 15 cases in Togo].
abstract: The goal of our study is to document the prevalence of change JAK2V617F among patients reached of myeloproliferative syndromes (MPS) in Togo in order to evaluate frequencies. This descriptive study included 15 patients followed with the CHU Campus for a SMP. The research of JAK2 change by PCR was carried out with the APHP Henri Mondor of Creteil (France). During the study period, 15 patients followed for MPS (9 cases of polycythemia Vera, 5 cases of essential thrombocytemia and a case of primitive myelofibrosis) profited from the research of JAK2 change. The Middle age of the patients was respectively of 45±18 years; of 55±6 years for the PV and the essential thrombocytemia. The patient followed for primitive myelofibrosis was 72 years old. Sex-ratio (H/F) was of 2. JAK2 Change was positive in 5 cases out of 9 (55.5%) of the polycythemia Vera, at 3 patients out of 5 (60%) followed for essential thrombocytemia but negative for patient reached of primitive myelofibrosis. In conclusion, JAK2 Change has an interest diagnosis and forecast in the MPS negative Chromosom Philadelphia and can be systematic even in Africa Sub-saharian.
authors.affiliation: Service d'hématologie, CHU Campus, Université de Lomé, Togo.
authors.forename: Essohana
authors.initials: E
authors.lastname: Padaro
authors.forename: Kossi
authors.initials: K
authors.lastname: Agbetiafa
authors.forename: Irénée Messanh
authors.initials: IM
authors.lastname: Delagnon Kueviakoe
authors.forename: Yao
authors.initials: Y
authors.lastname: Layibo
authors.forename: Koffi
authors.initials: K
authors.lastname: Amegbor
authors.forename: Ahoefa
authors.initials: A
authors.lastname: Vovor
authors.forename: Stéphane
authors.initials: S
authors.lastname: Giraudier
authors.forename: Ibrahima
authors.initials: I
authors.lastname: Sanogo
authors.forename: Akueté Yvon
authors.initials: AY
authors.lastname: Segbena
mesh_terms: D000328:Adult; D000368:Aged; D019943:Amino Acid Substitution / Q000502:physiology; D015331:Cohort Studies; D005260:Female; D006801:Humans; D053614:Janus Kinase 2 / Q000235:genetics*; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D020125:Mutation, Missense / Q000502:physiology; D009196:Myeloproliferative Disorders / Q000175:diagnosis / Q000453:epidemiology / Q000235:genetics*; D010649:Phenylalanine / Q000235:genetics; D010677:Philadelphia Chromosome; D011379:Prognosis; D014037:Togo / Q000453:epidemiology; D014633:Valine / Q000235:genetics
chemical_list: D010649:Phenylalanine; C507924:JAK2 protein, human; D053614:Janus Kinase 2; D014633:Valine