title: Interactions of marine-derived γ-pyrone natural products with phospholipid membranes.
abstract: The sacoglossan mollusc-derived metabolite, tridachiahydropyrone (3), and its proposed biosynthetic precursors (1 and 2) form part of a complex chemical defence system against predators and harmful UV light. Here, we provide supporting biophysical evidence that the metabolites become selectively localised at cell membranes and outline a binding scheme that accommodates the observed data. The possibility that localised lipid domains within the membrane have an effect on the localisation is also addressed.
authors.affiliation: School of Chemistry, University of Nottingham, Nottingham, England, UK.
authors.forename: Kimberley J
authors.initials: KJ
authors.lastname: Powell
authors.forename: Pallavi
authors.initials: P
authors.lastname: Sharma
authors.forename: Joanna L
authors.initials: JL
authors.lastname: Richens
authors.forename: Benjamin M
authors.initials: BM
authors.lastname: Davis
authors.forename: John E
authors.initials: JE
authors.lastname: Moses
authors.forename: Paul
authors.initials: P
authors.lastname: O'Shea
mesh_terms: D001688:Biological Products / Q000737:chemistry* / Q000378:metabolism; D008051:Lipid Bilayers / Q000737:chemistry* / Q000378:metabolism; D015394:Molecular Structure; D010743:Phospholipids / Q000737:chemistry* / Q000378:metabolism; D011753:Pyrones / Q000737:chemistry* / Q000378:metabolism; D014466:Ultraviolet Rays
chemical_list: D001688:Biological Products; D008051:Lipid Bilayers; D010743:Phospholipids; D011753:Pyrones; C507269:tridachiahydropyrone