title: Interventions for youth at high risk for bipolar disorder and schizophrenia.
abstract: Increasing evidence from retrospective and prospective studies is beginning to validate criteria to identify individuals at high risk for developing bipolar disorder or schizophrenia. In parallel, intervention trials are evaluating the efficacy and tolerability of pharmacologic and nonpharmacologic approaches for the treatment of subthreshold and possibly prodromal presentations in these high-risk populations with the ultimate objective of mitigating illness progression. This article reviews current evidence for candidate interventions for high-risk individuals to guide future research in this rapidly emerging field. A clinical vignette describing antidepressant-induced manic symptoms in an adolescent with a family history of bipolar disorder is provided.
authors.affiliation: Division of Bipolar Disorders Research, Department of Psychiatry and Behavioral Neuroscience, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA.
authors.forename: Robert K
authors.initials: RK
authors.lastname: McNamara
authors.forename: Jeffrey R
authors.initials: JR
authors.lastname: Strawn
authors.forename: Kiki D
authors.initials: KD
authors.lastname: Chang
authors.forename: Melissa P
authors.initials: MP
authors.lastname: DelBello
mesh_terms: D000293:Adolescent; D000928:Antidepressive Agents / Q000627:therapeutic use*; D014150:Antipsychotic Agents / Q000627:therapeutic use*; D001714:Bipolar Disorder / Q000175:diagnosis* / Q000188:drug therapy / Q000517:prevention & control; D061345:Early Medical Intervention; D006801:Humans; D062706:Prodromal Symptoms; D011618:Psychotic Disorders / Q000175:diagnosis* / Q000188:drug therapy / Q000517:prevention & control; D012307:Risk Factors; D012559:Schizophrenia / Q000175:diagnosis* / Q000188:drug therapy / Q000517:prevention & control
chemical_list: D000928:Antidepressive Agents; D014150:Antipsychotic Agents