title: Molecular mechanisms of mucocutaneous immunity against Candida and Staphylococcus species.
abstract: Signal transducer and activator of transcription (STAT) proteins are key components of the innate and adaptive immune responses to pathogenic microorganisms. Recent research on primary immunodeficiency disorders and the identification of patients carrying germline mutations in STAT1, STAT3, and STAT5B have highlighted the role of human STATs in host defense against various viruses, bacteria, and fungi. Mutations in STAT1 and STAT3 disrupt various cytokine pathways that control mucocutaneous immunity against Candida species, especially Candida albicans, and Staphylococcus species, especially Staphylococcus aureus. Here we consider inborn errors of immunity arising from mutations in either STAT1 or STAT3 that affect mucocutaneous immunity to Candida and Staphylococcus species.
authors.affiliation: Department of Infectious and Pediatric Immunology, University of Debrecen Medical and Health Science Center, Debrecen, Hungary. lmarodi@dote.hu
authors.forename: László
authors.initials: L
authors.lastname: Maródi
authors.forename: Sophie
authors.initials: S
authors.lastname: Cypowyj
authors.forename: Beáta
authors.initials: B
authors.lastname: Tóth
authors.forename: Liudmyla
authors.initials: L
authors.lastname: Chernyshova
authors.forename: Anne
authors.initials: A
authors.lastname: Puel
authors.forename: Jean-Laurent
authors.initials: JL
authors.lastname: Casanova
mesh_terms: D000818:Animals; D002175:Candida / Q000276:immunology*; D002177:Candidiasis / Q000209:etiology / Q000276:immunology*; D002648:Child; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D018928:Immunity, Mucosal / Q000235:genetics; D007153:Immunologic Deficiency Syndromes / Q000150:complications / Q000235:genetics / Q000276:immunology*; D008297:Male; D016884:Polyendocrinopathies, Autoimmune; D011110:Polymorphism, Genetic; D012306:Risk; D050791:STAT Transcription Factors / Q000235:genetics / Q000276:immunology; D015398:Signal Transduction; D012867:Skin / Q000276:immunology / Q000382:microbiology / Q000473:pathology; D013203:Staphylococcal Infections / Q000209:etiology / Q000276:immunology*; D013210:Staphylococcus / Q000276:immunology*; D055815:Young Adult
chemical_list: D050791:STAT Transcription Factors