title: A multimineral natural product from red marine algae reduces colon polyp formation in C57BL/6 mice.
abstract: The goal of this study was to determine if a multimineral natural product derived from red marine algae could reduce colon polyp formation in mice on a high-fat diet. C57BL/6 mice were maintained for up to 18 mo either on a high-fat "Western-style" diet or on a low-fat diet (AIN 76A), with or without the multimineral-supplement. To summarize, colon polyps were detected in 22 of 70 mice (31%) on the high-fat diet but in only 2 of 70 mice (3%) receiving the mineral-supplemented high-fat diet (P < 0.0001). Colon polyps were detected in 16 of 70 mice (23%) in the low-fat group; not significantly different from high-fat group but significantly higher than the high-fat-supplemented group (P = 0.0006). This was in spite of the fact that the calcium level in the low-fat diet was comparable to the level of calcium in the high-fat diet containing the multimineral-product. Supplementation of the low-fat diet reduced the incidence to 8 of 70 mice (11% incidence). Taken together, these findings demonstrate that a multimineral natural product can protect mice on a high-fat diet against adenomatous polyp formation in the colon. These data suggest that increased calcium alone is insufficient to explain the lower incidence of colon polyps.
authors.affiliation: Department of Pathology, The University of Michigan, Ann Arbor, Michigan 48109, USA. mnaslam@umich.edu
authors.forename: Muhammad N
authors.initials: MN
authors.lastname: Aslam
authors.forename: Ingrid
authors.initials: I
authors.lastname: Bergin
authors.forename: Madhav
authors.initials: M
authors.lastname: Naik
authors.forename: Tejaswi
authors.initials: T
authors.lastname: Paruchuri
authors.forename: Anna
authors.initials: A
authors.lastname: Hampton
authors.forename: Muneeb
authors.initials: M
authors.lastname: Rehman
authors.forename: Michael K
authors.initials: MK
authors.lastname: Dame
authors.forename: Howard
authors.initials: H
authors.lastname: Rush
authors.forename: James
authors.initials: J
authors.lastname: Varani
mesh_terms: D000818:Animals; D002136:Calcium, Dietary / Q000008:administration & dosage; D003106:Colon / Q000187:drug effects / Q000473:pathology; D003111:Colonic Polyps / Q000188:drug therapy* / Q000473:pathology; D018752:Diet, Fat-Restricted; D059305:Diet, High-Fat; D004041:Dietary Fats / Q000008:administration & dosage; D019587:Dietary Supplements; D005260:Female; D005770:Gastrointestinal Neoplasms / Q000188:drug therapy / Q000473:pathology; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D000461:Rhodophyta / Q000737:chemistry*; D014131:Trace Elements / Q000008:administration & dosage*
chemical_list: D002136:Calcium, Dietary; D004041:Dietary Fats; D014131:Trace Elements