title: In vivo spatially localized high resolution 1H MRS via intermolecular single-quantum coherence of rat brain at 7 T.
abstract: OBJECTIVE
  To compare the conventional localized point-resolved spectroscopy (PRESS) with localized 2D intermolecular single-quantum coherence (iSQC) magnetic resonance spectroscopy (MRS) and obtain in vivo MRS spectrum of rat brain using the latter technique.
  
  
  METHODS
  A brain phantom, an intact pig brain tissue, and mature Sprague-Dawley rat were studied by PRESS, Nano magic-angle spinning spectroscopy, and iSQC MRS.
  
  
  RESULTS
  Using PRESS, high-resolution MRS can be obtained from the brain phantom and pig brain tissue with a small voxel in a relatively homogeneous field. When a large voxel is selected, the field homogeneity is distinctly reduced. No useful information is obtained from the PRESS spectra. However, using the iSQC MRS, high-resolution spectra can be obtained from the two samples with a relatively large voxel. In the same way, an iSQC MRS spectrum can be obtained from a relatively large voxel of in vivo rat brain with a comparable resolution to the PRESS spectrum with a small voxel.
  
  
  CONCLUSIONS
  Compared to PRESS, the iSQC MRS may be more feasible and promising for detection of strongly structured tissues with relatively large voxels.
authors.affiliation: Department of Electronic Science, Fujian Provincial Key Laboratory of Plasma and Magnetic Resonance, State Key Laboratory of Physical Chemistry of Solid Surfaces, Xiamen University, Xiamen, China.
authors.forename: Xiaohong
authors.initials: X
authors.lastname: Cui
authors.forename: Jianfeng
authors.initials: J
authors.lastname: Bao
authors.forename: Yuqing
authors.initials: Y
authors.lastname: Huang
authors.forename: Shuhui
authors.initials: S
authors.lastname: Cai
authors.forename: Zhong
authors.initials: Z
authors.lastname: Chen
mesh_terms: D000465:Algorithms; D000818:Animals; D001923:Brain Chemistry; D009682:Magnetic Resonance Spectroscopy / Q000379:methods*; D011522:Protons; D051381:Rats; D017207:Rats, Sprague-Dawley; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D013552:Swine
chemical_list: D011522:Protons