title: Temporomandibular joint arthritis in sickle cell disease: a case report.
abstract: We report a rare case of aseptic arthritis in the temporomandibular joint of a patient with sickle cell anemia. A 22-year-old woman with sickle cell disease, in the 18th week of gestation, was referred by her hematologist to investigate a sudden mouth opening limitation and severe pain on her left cheek. The patient received a standard pain assessment protocol, clinical examination, and complementary exams (complete blood count, hemoglobin electrophoresis, blood solubility test, panoramic radiograph, and magnetic resonance imaging [MRI]). The blood results were consistent with a sickle cell crisis and the MRI showed an inflammatory process around the left temporomandibular joint. Treatment with opioid analgesics and blood transfusion provided good results. Sickle cell anemia is a disease that can cause arthritis of the temporomandibular joint, and although it is rare, clinicians should be attentive to the differential diagnosis in patients with this disease.
authors.affiliation: Orofacial Pain Team, Dentistry Division, Hospital das Clinicas, Medical School, University of São Paulo, São Paulo, Brazil.
authors.forename: Maíra da Silva
authors.initials: Mda S
authors.lastname: Caracas
authors.forename: Sumatra P
authors.initials: SP
authors.lastname: Jales
authors.forename: Levi H
authors.initials: LH
authors.lastname: Jales Neto
authors.forename: Joice Carla
authors.initials: JC
authors.lastname: da Silva Castro
authors.forename: Liliana Mitie
authors.initials: LM
authors.lastname: Suganuma
authors.forename: Guilherme Henrique Hencklain
authors.initials: GH
authors.lastname: Fonseca
authors.forename: Sandra Fatima Menosi
authors.initials: SF
authors.lastname: Gualandro
authors.forename: José Tadeu Tesseroli
authors.initials: JT
authors.lastname: de Siqueira
mesh_terms: D000701:Analgesics, Opioid / Q000627:therapeutic use; D000755:Anemia, Sickle Cell / Q000150:complications* / Q000628:therapy; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use; D005157:Facial Pain / Q000188:drug therapy* / Q000473:pathology; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D010003:Osteoarthritis / Q000188:drug therapy* / Q000473:pathology*; D010147:Pain Measurement; D011247:Pregnancy; D011862:Radiography, Panoramic; D013704:Temporomandibular Joint / Q000473:pathology*; D055815:Young Adult
chemical_list: D000701:Analgesics, Opioid; D000894:Anti-Inflammatory Agents, Non-Steroidal