title: Platelet-rich plasma enhances the dermal regeneration efficacy of human adipose-derived stromal cells administered to skin wounds.
abstract: The administration of human adipose-derived stromal cells (hASCs) enhances skin wound healing. However, poor survival of hASCs that are administered to avascular wound regions may limit the therapeutic efficacy of the hASCs. The aim of this study was to determine whether the coadministration of platelet-rich plasma (PRP) and hASCs enhanced the skin wound-healing efficacy of hASCs. Skin regeneration was examined in skin wounds of athymic mice that were either untreated or treated with hASCs, PRP, or both hASCs and PRP. Coadministration of PRP and hASCs resulted in better skin regeneration than hASC administration alone in part by significantly improving the proliferation of administered hASCs by the angiogenic growth factor secretion of the hASCs and surrounding mouse host cells in the wound areas and by promoting neovascularization in the wound beds.
authors.affiliation: School of Chemical and Biological Engineering, Seoul National University, Seoul, Republic of Korea.
authors.forename: Suk Ho
authors.initials: SH
authors.lastname: Bhang
authors.forename: Jooyeon
authors.initials: J
authors.lastname: Park
authors.forename: Hee Seok
authors.initials: HS
authors.lastname: Yang
authors.forename: Jaehoon
authors.initials: J
authors.lastname: Shin
authors.forename: Byung-Soo
authors.initials: BS
authors.lastname: Kim
mesh_terms: D017667:Adipocytes / Q000166:cytology*; D000328:Adult; D000818:Animals; D049109:Cell Proliferation; D005260:Female; D016222:Fibroblast Growth Factor 2 / Q000378:metabolism; D017228:Hepatocyte Growth Factor / Q000378:metabolism; D006801:Humans; D008297:Male; D051379:Mice; D008819:Mice, Nude; D018919:Neovascularization, Physiologic; D053657:Platelet-Rich Plasma / Q000166:cytology*; D018809:Proliferating Cell Nuclear Antigen / Q000378:metabolism; D012867:Skin / Q000378:metabolism; D012871:Skin Diseases / Q000628:therapy*; D017154:Stromal Cells / Q000166:cytology* / Q000637:transplantation; D042461:Vascular Endothelial Growth Factor A / Q000378:metabolism; D014945:Wound Healing; D055815:Young Adult
chemical_list: D018809:Proliferating Cell Nuclear Antigen; D042461:Vascular Endothelial Growth Factor A; D016222:Fibroblast Growth Factor 2; D017228:Hepatocyte Growth Factor