title: Synthesis of chiral sulfoximine-based thioureas and their application in asymmetric organocatalysis.
abstract: For the first time, chiral sulfoximine derivatives have been applied as asymmetric organocatalysts. In combination with a thiourea-type backbone the sulfonimidoyl moiety leads to organocatalysts showing good reactivity in the catalytic desymmetrization of a cyclic meso-anhydride and moderate enantioselectivity in the catalytic asymmetric Biginelli reaction. Straightforward synthetic routes provide the newly designed thiourea-sulfoximine catalysts in high overall yields without affecting the stereohomogeneity of the sulfur-containing core fragment.
authors.affiliation: Institut für Organische Chemie, Landoltweg 1, RWTH Aachen University, 52074 Aachen, Germany.
authors.forename: Marcus
authors.initials: M
authors.lastname: Frings
authors.forename: Isabelle
authors.initials: I
authors.lastname: Thomé
authors.forename: Carsten
authors.initials: C
authors.lastname: Bolm