title: Molecular description of the propagation of chirality from molecules to complex systems: different mechanisms controlled by hydrophobic interactions.
abstract: In this work a combined theoretical and experimental approach was used to elucidate and describe at the molecular level the basic interactions that drive the transfer of the chiral information from chiral surfactant molecules to dye/surfactant assemblies. It was found that both hydrophobic interactions and relative concentrations strongly influence the chiroptical features of the heteroaggregates. In particular it was observed that, depending on the length of the surfactant hydrophobic chain, the chiral information is transferred to the dye by stabilizing an enantiomer either of a chiral conformer or of a chiral topological arrangement. These findings underline the role of hydrophobic interactions in the transfer of chirality and provide an example of the potential of in silico simulations for providing an accurate description of the process of chirality propagation.
authors.affiliation: Theoretical Molecular Biophysics Group, Max Planck Institute of Biophysics, Frankfurt am Main, Germany. Fabrizio.Marinelli@biophys.mpg.de
authors.forename: Fabrizio
authors.initials: F
authors.lastname: Marinelli
authors.forename: Alessandro
authors.initials: A
authors.lastname: Sorrenti
authors.forename: Valentina
authors.initials: V
authors.lastname: Corvaglia
authors.forename: Vanessa
authors.initials: V
authors.lastname: Leone
authors.forename: Giovanna
authors.initials: G
authors.lastname: Mancini
mesh_terms: D057927:Hydrophobic and Hydrophilic Interactions; D008962:Models, Theoretical; D008968:Molecular Conformation; D015394:Molecular Structure; D013237:Stereoisomerism; D013499:Surface Properties; D013501:Surface-Active Agents / Q000737:chemistry*
chemical_list: D013501:Surface-Active Agents