title: Sirtuin activation: a role for plasma membrane in the cell growth puzzle.
abstract: For more than 20 years, the observation that impermeable oxidants can stimulate cell growth has not been satisfactorily explained. The discovery of sirtuins provides a logical answer to the puzzle. The NADH-dependent transplasma membrane electron transport system, which is stimulated by growth factors and interventions such as calorie restriction, can transfer electrons to external acceptors and protect against stress-induced apoptosis. We hypothesize that the activation of plasma membrane electron transport contributes to the cytosolic NAD(+) pool required for sirtuin to activate transcription factors necessary for cell growth and survival.
authors.affiliation: Biology Department, Purdue University, West Lafayette, IN, USA.
authors.forename: Frederick L
authors.initials: FL
authors.lastname: Crane
authors.forename: Plácido
authors.initials: P
authors.lastname: Navas
authors.forename: Hans
authors.initials: H
authors.lastname: Low
authors.forename: Iris L
authors.initials: IL
authors.lastname: Sun
authors.forename: Rafael
authors.initials: R
authors.lastname: de Cabo
mesh_terms: D017209:Apoptosis / Q000502:physiology; D002453:Cell Cycle / Q000502:physiology; D048708:Cell Growth Processes / Q000502:physiology*; D002462:Cell Membrane / Q000378:metabolism*; D016922:Cellular Senescence / Q000502:physiology*; D004579:Electron Transport / Q000502:physiology*; D004789:Enzyme Activation; D006801:Humans; D009243:NAD / Q000378:metabolism; D016660:NAD(P)H Dehydrogenase (Quinone) / Q000378:metabolism; D010084:Oxidation-Reduction; D011990:Receptors, Transferrin / Q000378:metabolism; D037761:Sirtuins / Q000378:metabolism*
chemical_list: D011990:Receptors, Transferrin; D009243:NAD; D016660:NAD(P)H Dehydrogenase (Quinone); D037761:Sirtuins