title: LOXL2 in epithelial cell plasticity and tumor progression.
abstract: Several members of the lysyl oxidase family have recently emerged as important regulators of tumor progression. Among them, LOXL2 has been shown to be involved in tumor progression and metastasis of several tumor types, including breast carcinomas. Secreted LOXL2 participates in the remodeling of the extracellular matrix of the tumor microenvironment, in a similar fashion to prototypical lysyl oxidase. In addition, new intracellular functions of LOXL2 have been described, such as its involvement in the regulation of the epithelial-to-mesenchymal transition, epithelial cell polarity and differentiation mediated by transcriptional repression mechanisms. Importantly, intracellular (perinuclear) expression of LOXL2 is associated with poor prognosis and distant metastasis of specific tumor types, such as larynx squamous cell carcinoma and basal breast carcinomas. These recent findings open new avenues for the therapeutic utility of LOXL2.
authors.affiliation: Departamento de Bioquímica, UAM, Instituto de Investigaciones Biomédicas Alberto Sols CSIC-UAM, IdiPAZ, Arzobispo Morcillo, 2, 28029 Madrid, Spain. acano@iib.uam.es
authors.forename: Amparo
authors.initials: A
authors.lastname: Cano
authors.forename: Patricia G
authors.initials: PG
authors.lastname: Santamaría
authors.forename: Gema
authors.initials: G
authors.lastname: Moreno-Bueno
mesh_terms: D000594:Amino Acid Oxidoreductases / Q000378:metabolism / Q000502:physiology*; D000818:Animals; D002448:Cell Adhesion; D016764:Cell Polarity; D049109:Cell Proliferation; D018450:Disease Progression; D004847:Epithelial Cells / Q000201:enzymology* / Q000502:physiology; D058750:Epithelial-Mesenchymal Transition; D006801:Humans; D009369:Neoplasms / Q000201:enzymology* / Q000473:pathology
chemical_list: D000594:Amino Acid Oxidoreductases; C119091:LOXL2 protein, human