title: Is physical activity able to modify oxidative damage in cardiovascular aging?
abstract: Aging is a multifactorial process resulting in damage of molecules, cells, and tissues. It has been demonstrated that the expression and activity of antioxidant systems (SOD, HSPs) are modified in aging, with reduced cell ability to counteract the oxidant molecules, and consequent weak resistance to ROS accumulation. An important mechanism involved is represented by sirtuins, the activity of which is reduced by aging. Physical activity increases the expression and the activity of antioxidant enzymes, with consequent reduction of ROS. Positive effects of physical exercise in terms of antioxidant activity could be ascribable to a greater expression and activity of SOD enzymes, HSPs and SIRT1 activity. The antioxidant effects could increase, decrease, or not change in relation to the exercise protocol. Therefore, some authors by using a new approach based on the in vivo/vitro technique demonstrated that the highest survival and proliferation and the lowest senescence were obtained by performing an aerobic training. Therefore, the in vivo/vitro technique described could represent a good tool to better understand how the exercise training mediates its effects on aging-related diseases, as elderly with heart failure that represents a special population in which the exercise plays an important role in the improvement of cardiovascular function, quality of life, and survival.
authors.affiliation: Department of Medicine and Health Sciences, University of Molise, Via Giovanni Paolo II, Località Tappino, 86100 Campobasso, Italy. graziamaria.corbi@unimol.it
authors.forename: Graziamaria
authors.initials: G
authors.lastname: Corbi
authors.forename: Valeria
authors.initials: V
authors.lastname: Conti
authors.forename: Giusy
authors.initials: G
authors.lastname: Russomanno
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Rengo
authors.forename: Piergiusto
authors.initials: P
authors.lastname: Vitulli
authors.forename: Anna Linda
authors.initials: AL
authors.lastname: Ciccarelli
authors.forename: Amelia
authors.initials: A
authors.lastname: Filippelli
authors.forename: Nicola
authors.initials: N
authors.lastname: Ferrara
mesh_terms: D000375:Aging / Q000502:physiology*; D000818:Animals; D000975:Antioxidants / Q000378:metabolism; D002319:Cardiovascular System / Q000378:metabolism*; D015444:Exercise; D006801:Humans; D018384:Oxidative Stress; D056564:Sirtuin 1 / Q000378:metabolism
chemical_list: D000975:Antioxidants; C447939:SIRT1 protein, human; D056564:Sirtuin 1