title: An alternative route for fondaparinux sodium synthesis via selective hydrogenations and sulfation of appropriate pentasaccharides.
abstract: A new approach for the synthesis of fondaparinux sodium starting from an appropriate protected pentasaccharide is presented. In this procedure, instead of the common last steps: sulfation-hydrogenation-sulfation, reverse ones: hydrogenation-sulfation-hydrogenation, are applied. Fondaparinux is afforded in a satisfactory yield and purity after the selective hydrogenation of the starting pentasaccharide using a continuous flow reactor and one-pot sulfation reaction followed by hydrogenation under catalytic hydrogen transfer conditions.
authors.affiliation: Organic Synthesis Laboratory, Adamed Sp. z o.o., Pienkow 149, 05-152 Czosnow, Poland. andrzej.manikowski@adamed.com.pl
authors.forename: Andrzej
authors.initials: A
authors.lastname: Manikowski
authors.forename: Anna
authors.initials: A
authors.lastname: Kozioł
authors.forename: Ewa
authors.initials: E
authors.lastname: Czajkowska-Wojciechowska
mesh_terms: D002236:Carbohydrate Conformation; D000077425:Fondaparinux; D006865:Hydrogenation; D008969:Molecular Sequence Data; D009844:Oligosaccharides / Q000737:chemistry*; D011134:Polysaccharides / Q000138:chemical synthesis* / Q000737:chemistry; D013431:Sulfates / Q000737:chemistry*
chemical_list: D009844:Oligosaccharides; D011134:Polysaccharides; D013431:Sulfates; D000077425:Fondaparinux