title: Fast dissolving eutectic compositions of curcumin.
abstract: The bioactive herbal ingredient curcumin was screened with pharmaceutically acceptable coformers to discover solid-state forms of high solubility. Mechano-chemical grinding of curcumin with cocrystal formers in a fixed stoichiometry ratio resulted in binary eutectic compositions of curcumin-coformer with nicotinamide (1:2), ferulic acid (1:1), hydroquinone (1:1), p-hydroxybenzoic acid (1:1), and l-tartaric acid (1:1). The eutectic nature of the product crystalline solids was established by differential scanning calorimetry, and the absence of hydrogen-bonded crystalline phases such as cocrystals/salts was ascertained by powder X-ray diffraction, IR-Raman, and solid-state NMR spectroscopy. The best case of CUR-NAM eutectic exhibits 10-fold faster IDR and 6-times higher AUC compared to crystalline curcumin.
authors.affiliation: School of Chemistry, University of Hyderabad, Prof. C. R. Rao Road, Gachibowli, Central University P.O., Hyderabad 500 046, India.
authors.forename: N Rajesh
authors.initials: NR
authors.lastname: Goud
authors.forename: Kuthuru
authors.initials: K
authors.lastname: Suresh
authors.forename: Palash
authors.initials: P
authors.lastname: Sanphui
authors.forename: Ashwini
authors.initials: A
authors.lastname: Nangia
mesh_terms: D002152:Calorimetry, Differential Scanning; D003460:Crystallization; D003474:Curcumin / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D033362:Powder Diffraction; D012995:Solubility; D013059:Spectrum Analysis, Raman; D014961:X-Ray Diffraction
chemical_list: D003474:Curcumin