title: Synthesis of compounds related to the anti-migraine drug eletriptan hydrobromide.
abstract: Eletriptan hydrobromide (1) is a selective serotonin (5-HT(1)) agonist, used for the acute treatment of the headache phase of migraine attacks. During the manufacture of eletriptan hydrobromide the formation of various impurities were observed and identified by LC-MS. To control the formation of these impurities during the preparation of active pharmaceutical ingredients, the structure of the impurities must be known. Major impurities of the eletriptan hydrobromide synthesis were prepared and characterized by using various spectroscopic techniques, i.e., mass spectroscopy, FTIR , (1)H NMR, (13)C NMR/DEPT, and further confirmed by co-injection in HPLC. The present study will be of great help in the synthesis of highly pure eletriptan hydrobromide related compounds.
authors.affiliation: Chemical Research and Development, Aurobindo Pharma Ltd., Survey No. 71 & 72, Indrakaran (V), Sangareddy (M), Medak Dist-502329, Andhra Pradesh, India ; Engineering Chemistry Department, AU College of Engineering, Andhra University, Visakhapatnam-530003, Andhra Pradesh, India.
authors.forename: Suri Babu
authors.initials: SB
authors.lastname: Madasu
authors.forename: Nagaji Ambabhai
authors.initials: NA
authors.lastname: Vekariya
authors.forename: M N V D Hari
authors.initials: MN
authors.lastname: Kiran
authors.forename: Badarinadh
authors.initials: B
authors.lastname: Gupta
authors.forename: Aminul
authors.initials: A
authors.lastname: Islam
authors.forename: Paul S
authors.initials: PS
authors.lastname: Douglas
authors.forename: Korupolu Raghu
authors.initials: KR
authors.lastname: Babu