title: Potential role of sirtuins in livestock production.
abstract: Sirtuins are NAD(+)-dependent histone and protein deacetylases, which have been studied during the last decade with a focus on their role in lifespan extension and age-related diseases under normal and calorie-restricted or pathological conditions. However, sirtuins also have the ability to regulate energy homeostasis as they can sense the metabolic state of the cell through the NAD(+)/NADH ratio; hence, changes in the diet can modify the expression of these enzymes. Dietary manipulations are a common practice currently being used in livestock production with favorable results, probably due in part to the enhanced activity of sirtuins. Nevertheless, sirtuin expression in livestock species has not been a research target. For these reasons, the goal of this review is to awaken interest in these enzymes for future detailed characterization in livestock species by presenting a general introduction to what sirtuins are, how they work and what is known about their role in livestock.
authors.affiliation: Programa de Posgrado en Ciencias de la Producción y de la Salud Animal, Universidad Nacional Autónoma de México, Mexico City, México.
authors.forename: Y
authors.initials: Y
authors.lastname: Ghinis-Hozumi
authors.forename: A
authors.initials: A
authors.lastname: Antaramian
authors.forename: F
authors.initials: F
authors.lastname: Villarroya
authors.forename: E
authors.initials: E
authors.lastname: Piña
authors.forename: O
authors.initials: O
authors.lastname: Mora
mesh_terms: D000822:Animal Husbandry; D000818:Animals; D031204:Caloric Restriction; D004032:Diet; D058751:Livestock / Q000378:metabolism*; D037761:Sirtuins / Q000737:chemistry / Q000378:metabolism*
chemical_list: D037761:Sirtuins