title: Organocatalytic asymmetric anti-selective Michael reactions of aldehydes and the sequential reduction/lactonization/Pauson-Khand reaction for the enantioselective synthesis of highly functionalized hydropentalenes.
abstract: A new method has been developed for the enantioselective synthesis of highly functionalized hydropentalenes bearing up to four stereogenic centers with high stereoselectivity (up to 99% ee). This process combines an enantioselective organocatalytic anti-selective Michael addition with a highly efficient one-pot reduction/lactonization/Pauson-Khand reaction sequence. The structures and absolute configurations of the products were confirmed by X-ray analysis.
authors.affiliation: Department of Chemistry and Biochemistry, National Chung Cheng University, Chia-Yi, 621, Taiwan, ROC. chebch@ccu.edu.tw
authors.forename: Bor-Cherng
authors.initials: BC
authors.lastname: Hong
authors.forename: Nitin S
authors.initials: NS
authors.lastname: Dange
authors.forename: Po-Jen
authors.initials: PJ
authors.lastname: Yen
authors.forename: Gene-Hsiang
authors.initials: GH
authors.lastname: Lee
authors.forename: Ju-Hsiou
authors.initials: JH
authors.lastname: Liao