title: Instigation of Notch signaling in the pathogenesis of Kaposi's sarcoma-associated herpesvirus and other human tumor viruses.
abstract: The Notch pathway is a highly conserved signaling circuit with a critical role in cell-fate determination and tumor initiation. Notch is reported to regulate various key events in tumor progression, such as angiogenesis, maintenance of cancer stem cells, resistance to therapeutic agents and metastasis. This review describes the intimate interplay of human tumor viruses with the Notch signaling pathway. Special attention is paid to Kaposi's sarcoma-associated herpesvirus, the etiological agent of Kaposi's sarcoma and rare lymphoproliferative disorders. The past decade of active research has led to significant advances in understanding how Kaposi's sarcoma-associated herpesvirus exploits the Notch pathway to regulate its replication phase and to modulate the host cellular microenvironment to make it more favorable for viral persistence and spreading.
authors.affiliation: Institute of Biotechnology & Research Programs Unit, Genome-Scale Biology, University of Helsinki, PO Box 56 (Viikinkaari 9), 00014 University of Helsinki, Helsinki, Finland.
authors.forename: Fang
authors.initials: F
authors.lastname: Cheng
authors.forename: Pirita
authors.initials: P
authors.lastname: Pekkonen
authors.forename: Päivi M
authors.initials: PM
authors.lastname: Ojala
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D019288:Herpesvirus 8, Human / Q000472:pathogenicity*; D006801:Humans; D008232:Lymphoproliferative Disorders / Q000473:pathology* / Q000821:virology*; D009858:Oncogenic Viruses / Q000472:pathogenicity*; D051880:Receptors, Notch / Q000378:metabolism*; D015398:Signal Transduction; D014777:Virus Diseases / Q000473:pathology* / Q000821:virology
chemical_list: D051880:Receptors, Notch