title: Ursane-type pentacyclic triterpenoids as useful platforms to discover anticancer drugs.
abstract: This review highlights the potential of natural and semisynthetic ursane-type triterpenoids as candidates for the design of multi-target bioactive compounds, with focus on their anticancer effects. A brief illustration of the biosynthesis, sources, and general biological effects of the main classes of naturally occurring pentacyclic triterpenoids (PTs) are provided.
authors.affiliation: Grupo de Química Farmacêutica, Faculdade de Farmácia, Universidade de Coimbra, Pólo das Ciências da Saúde, Azinhaga de Santa Comba, 3000-548 Coimbra, Portugal. salvador@ci.uc.pt
authors.forename: Jorge A R
authors.initials: JA
authors.lastname: Salvador
authors.forename: Vânia M
authors.initials: VM
authors.lastname: Moreira
authors.forename: Bruno M F
authors.initials: BM
authors.lastname: Gonçalves
authors.forename: Ana S
authors.initials: AS
authors.lastname: Leal
authors.forename: Yongkui
authors.initials: Y
authors.lastname: Jing
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D001688:Biological Products / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D015394:Molecular Structure; D053978:Pentacyclic Triterpenes / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology
chemical_list: D000970:Antineoplastic Agents; D001688:Biological Products; D053978:Pentacyclic Triterpenes