title: Hospital-based prevalence of high-risk cervical HPV types infecting the general population and female sex workers in Huzhou, China.
abstract: OBJECTIVE
  To evaluate the prevalence of high-risk HPV types among female sex workers and the general population in Huzhou, China.
  
  
  METHODS
  Cervical samples from the general population (n=292) and female sex workers (n=288) in Huzhou, China, were collected between April, 2008, and October, 2009. Demographic, behavioral, and clinical data were obtained by interview. Genotyping of the HPV L1 gene was done via a PGMY09/PGMY11 PCR-based assay, and the cervical samples were subjected to cytology analysis.
  
  
  RESULTS
  The prevalence of HPV was higher among female sex workers (66.7%) than among the general population (19.2%). Among female sex workers, HPV-16 (28.8%) was the most prevalent, followed by HPV-58 (24.0%) and HPV-52 (20.8%). The percentage of cervical abnormalities was higher among female sex workers (20.8%) than among the general population (4.8%). Multivariate analysis showed that education level and condom use during coitus were significantly associated with HPV infection (P<0.05). HPV-16, HPV-58 and HPV-52 were the dominant types, and were significantly associated with abnormal cervical cytology (P<0.05).
  
  
  CONCLUSIONS
  Female sex workers in Huzhou, China, were found to have a greater probability of being infected with high-risk HPV, and novel vaccines against HPV-58 and HPV-52 should be developed. Using condoms could reduce the risk of infection.
authors.affiliation: Huzhou Key Laboratory of Molecular Medicine, Huzhou Central Hospital, Huzhou, China.
authors.forename: Xiang
authors.initials: X
authors.lastname: Wang
authors.forename: Donghua
authors.initials: D
authors.lastname: Gu
authors.forename: Bin
authors.initials: B
authors.lastname: Lou
authors.forename: Bin
authors.initials: B
authors.lastname: Xu
authors.forename: Fuchu
authors.initials: F
authors.lastname: Qian
authors.forename: Yu
authors.initials: Y
authors.lastname: Chen
mesh_terms: D000293:Adolescent; D000328:Adult; D036022:Capsid Proteins / Q000235:genetics; D002584:Cervix Uteri / Q000473:pathology / Q000821:virology*; D002681:China / Q000453:epidemiology; D017280:Condoms / Q000706:statistics & numerical data; D004522:Educational Status; D005260:Female; D005838:Genotype; D006801:Humans; D015999:Multivariate Analysis; D009856:Oncogene Proteins, Viral / Q000235:genetics; D027383:Papillomaviridae / Q000235:genetics / Q000302:isolation & purification*; D030361:Papillomavirus Infections / Q000453:epidemiology* / Q000821:virology; D016133:Polymerase Chain Reaction; D015995:Prevalence; D011477:Sex Work; D055815:Young Adult
chemical_list: D036022:Capsid Proteins; C114580:HPV L1 protein, Human papillomavirus; D009856:Oncogene Proteins, Viral