title: Enantioselective construction of sterically hindered tertiary α-aryl ketones: a catalytic asymmetric synthesis of isoflavanones.
abstract: A method for the catalytic asymmetric α-arylation of ketones bearing very sterically hindered aryl rings has been developed. This reaction occurs under mild conditions, in short reaction times and has been applied to the first catalytic asymmetric synthesis of isoflavanones.
authors.affiliation: Centre for Synthesis and Chemical Biology, School of Chemistry and Chemical Biology, University College Dublin, Belfield, Dublin 4, Ireland.
authors.forename: Michael P
authors.initials: MP
authors.lastname: Carroll
authors.forename: Helge
authors.initials: H
authors.lastname: Müller-Bunz
authors.forename: Patrick J
authors.initials: PJ
authors.lastname: Guiry
mesh_terms: D002384:Catalysis; D044950:Flavanones / Q000138:chemical synthesis* / Q000737:chemistry; D007659:Ketones / Q000737:chemistry*; D010165:Palladium / Q000737:chemistry; D013237:Stereoisomerism
chemical_list: D044950:Flavanones; D007659:Ketones; D010165:Palladium