title: Mean platelet volume and extent and complexity of coronary artery disease in diabetic and nondiabetic patients with ST elevation myocardial infarction.
abstract: We investigated whether the mean platelet volume (MPV) is associated with the extent and complexity of coronary artery disease in patients with ST elevation myocardial infarction (STEMI). We prospectively included 912 STEMI patients (663 male and 249 female; mean age 58.7 ± 12.4 years) who underwent primary percutaneous coronary intervention. The patients were divided into 3 groups according to MPV tertiles. Highest SYNTAX score (SS) was observed in MPVhigh group compared with MPVmid and MPVlow groups (P < .001 for all). The SS of MPVmid group was higher than MPVlow group (P = .036). The MPV in diabetic STEMI patients was higher than in nondiabetic STEMI patients (P < .001). Multivariate linear regression analysis showed that the MPV was associated with diabetes (β = .115, P = .001), troponin level (β = .131, P = .001), platelet count (β = -.241, P < .001), and SS (β = .216, P < .001). The relation between MPV and SS in diabetic STEMI patients was stronger than for nondiabetic STEMI patients (r = .473, P < .001 vs r = .129, P = .001).
authors.affiliation: Department of Cardiology, Adana Numune Education and Research Hospital, Adana, Turkey. dysahin79@hotmail.com
authors.forename: Durmuş Yildiray
authors.initials: DY
authors.lastname: Sahin
authors.forename: Mustafa
authors.initials: M
authors.lastname: Gür
authors.forename: Zafer
authors.initials: Z
authors.lastname: Elbasan
authors.forename: Ibrahim
authors.initials: I
authors.lastname: Özdoğru
authors.forename: Onur Kadir
authors.initials: OK
authors.lastname: Uysal
authors.forename: Ali
authors.initials: A
authors.lastname: Kivrak
authors.forename: Gökhan
authors.initials: G
authors.lastname: Gözübüyük
authors.forename: Caner
authors.initials: C
authors.lastname: Türkoğlu
authors.forename: Buğra
authors.initials: B
authors.lastname: Ozkan
authors.forename: Murat
authors.initials: M
authors.lastname: Cayli
mesh_terms: D000328:Adult; D000368:Aged; D001792:Blood Platelets / Q000473:pathology*; D048429:Cell Size; D017023:Coronary Angiography; D003324:Coronary Artery Disease / Q000097:blood* / Q000601:surgery; D003920:Diabetes Mellitus / Q000097:blood*; D004452:Echocardiography; D005260:Female; D006801:Humans; D016014:Linear Models; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000097:blood*; D010976:Platelet Count; D011446:Prospective Studies