title: NKG2D expression on HIV-specific CD8+ T cells is reduced in viremic HIV-1-infected patients but maintained in HIV controllers.
abstract: NKG2D mediates an important costimulatory pathway in CD8 T cells. In HIV infection, the authors found that NKG2D expression on both total CD8 and HIV-specific CD8 T cells was significantly lower in viremic patients than in HIV controllers. Antiretroviral therapy partially restored NKG2D expression on HIV-specific CD8 T cells. The authors observed a negative correlation between the respective expression levels of CD38 and NKG2D on total CD8 and HIV-specific CD8 T cells. The maintenance of NKG2D expression on CD8 T cells in HIV controllers may contribute to better cell function.
authors.affiliation: INSERM, U1012, Le Kremlin Bicêtre, France.
authors.forename: Camille
authors.initials: C
authors.lastname: Lecuroux
authors.forename: Asier
authors.initials: A
authors.lastname: Saez-Cirion
authors.forename: Nicolas
authors.initials: N
authors.lastname: Noel
authors.forename: Lilia
authors.initials: L
authors.lastname: Ben-Lamine
authors.forename: Isabelle
authors.initials: I
authors.lastname: Girault
authors.forename: Sophie
authors.initials: S
authors.lastname: Caillat-Zucman
authors.forename: Daniel
authors.initials: D
authors.lastname: Scott-Algara
authors.forename: Alain
authors.initials: A
authors.lastname: Venet
authors.forename: Olivier
authors.initials: O
authors.lastname: Lambotte
mesh_terms: D019380:Anti-HIV Agents / Q000008:administration & dosage; D018414:CD8-Positive T-Lymphocytes / Q000737:chemistry* / Q000276:immunology*; D015658:HIV Infections / Q000188:drug therapy / Q000276:immunology*; D020276:HIV Long-Term Survivors; D015497:HIV-1 / Q000276:immunology*; D006801:Humans; D055655:NK Cell Lectin-Like Receptor Subfamily K / Q000032:analysis*; D016896:Treatment Outcome; D014766:Viremia / Q000276:immunology
chemical_list: D019380:Anti-HIV Agents; C527085:KLRK1 protein, human; D055655:NK Cell Lectin-Like Receptor Subfamily K