title: Elevated neurobehavioral symptoms are associated with everyday functioning problems in chronic methamphetamine users.
abstract: Chronic methamphetamine (MA) use is commonly associated with neural injury and neurocognitive deficits. The authors examined the nature and correlates of self-reported neurobehavioral symptoms (e.g., apathy, disinhibition, and executive dysfunction) in 73 individuals with histories of MA dependence (MA+) and 85 comparison participants with comparable demographics and risk histories. MA+ individuals endorsed significantly more severe neurobehavioral symptoms on the Frontal Systems Behavioral Scale, especially those of disinhibition and executive dysfunction. Elevations in neurobehavioral symptoms were independent of common comorbidities, including hepatitis C infection, attention-deficit/hyperactivity disorder (ADHD), mood disorders, and other substance-use factors. Notably, the severity of neurobehavioral symptoms was uniquely associated with self-reported decrements in instrumental activities of daily living in the MA-dependent sample. Findings indicate that chronic MA users may experience elevated neurobehavioral symptoms of disinhibition and executive dysfunction, potentially increasing their risk of functional declines.
authors.affiliation: Joint Doctoral Program in Clinical Psychology, San Diego State University, La Jolla, CA, USA.
authors.forename: Jordan E
authors.initials: JE
authors.lastname: Cattie
authors.forename: Steven Paul
authors.initials: SP
authors.lastname: Woods
authors.forename: Jennifer E
authors.initials: JE
authors.lastname: Iudicello
authors.forename: Carolina
authors.initials: C
authors.lastname: Posada
authors.forename: Igor
authors.initials: I
authors.lastname: Grant
mesh_terms: D000203:Activities of Daily Living / Q000523:psychology; D000328:Adult; D019969:Amphetamine-Related Disorders / Q000150:complications* / Q000523:psychology*; D002908:Chronic Disease; D003072:Cognition Disorders / Q000209:etiology*; D056344:Executive Function / Q000502:physiology; D005260:Female; D006801:Humans; D007266:Inhibition, Psychological; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests; D011569:Psychiatric Status Rating Scales; D057566:Self Report