title: First report of KPC-producing Klebsiella pneumoniae in Croatia.
abstract: In February 2011, a 78-year-old male patient was admitted to Clinical Hospital Center Zagreb with subdural haematoma. Klebsiella pneumoniae with reduced susceptibility to carbapenems was isolated. PCR revealed the presence of bla(KPC), bla(TEM),  and bla(SHV) genes. Sequencing of bla(KPC) gene identified K. pneumoniae carbapenemase (KPC)-2 beta-lactamase. The strain belonged to ST37 clone by multilocus sequence typing. Infection control efforts limited the spread of KPC-producing clone of K.  pneumoniae in our hospital so far. To our knowledge, this is the first report of a KPC-producing K. pneumoniae in Croatia.
authors.affiliation: School of Medicine, University of Zagreb, Zagreb, Croatia. branka.bedenic@zg.t-com.hr
authors.forename: Branka
authors.initials: B
authors.lastname: Bedenić
authors.forename: Annarita
authors.initials: A
authors.lastname: Mazzariol
authors.forename: Vanda
authors.initials: V
authors.lastname: Plečko
authors.forename: Zrinka
authors.initials: Z
authors.lastname: Bošnjak
authors.forename: Petra
authors.initials: P
authors.lastname: Barl
authors.forename: Jasmina
authors.initials: J
authors.lastname: Vraneš
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Cornaglia
mesh_terms: D000368:Aged; D001426:Bacterial Proteins / Q000235:genetics / Q000378:metabolism*; D015780:Carbapenems / Q000378:metabolism / Q000494:pharmacology*; D017523:Croatia; D024901:Drug Resistance, Multiple, Bacterial; D017809:Fatal Outcome; D006408:Hematoma, Subdural / Q000601:surgery; D006801:Humans; D007710:Klebsiella Infections / Q000188:drug therapy / Q000382:microbiology*; D007711:Klebsiella pneumoniae / Q000187:drug effects* / Q000302:isolation & purification / Q000378:metabolism*; D008297:Male; D016920:Meningitis, Bacterial / Q000188:drug therapy / Q000382:microbiology; D011183:Postoperative Complications / Q000188:drug therapy / Q000382:microbiology; D001618:beta-Lactamases / Q000235:genetics / Q000378:metabolism*
chemical_list: D001426:Bacterial Proteins; D015780:Carbapenems; D001618:beta-Lactamases; C547585:beta-lactamase KPC-2, Klebsiella pneumoniae