title: Correlation between mesenteric fat thickness and serum apolipoproteins in patients with peripheral arterial occlusive disease.
abstract: BACKGROUND
  Visceral fat possesses the most detrimental potential for cardiovascular morbidity through the release of adipokines, as well as metabolic and proinflammatory mediators, which adversely affect metabolic and vascular homeostasis. Among the different types of visceral adipose tissue, mesenteric fat is considered particularly detrimental, due to its close proximity to the portal circulation, affecting directly the liver, which is the main regulator of body metabolic homeostasis. Mesenteric fat can be reliably estimated using abdominal ultrasonography, the only available imaging method able to depict individual mesenteric leaves. Aim of the present study was to investigate the correlation of mesenteric fat thickness (MFT) with serum apolipoprotein levels in patients undergoing digital subtraction angiography in a single center.
  
  
  METHODS
  35 male patients with peripheral arterial disease were examined. After careful examination of the periumbilical area, the mesenteric leaves were identified. The maximal distance between each pair of sequential leaves was measured, and the mean value of the three thickest leaves was determined as the mesenteric fat thickness. Six apolipoprotein fasting serum concentrations were measured using a Luminex proteomics platform (xMAP Multiplex immunoassay): apolipoprotein A-I (apoAI), apolipoprotein A-II (apoAII), apolipoprotein B (apoB), apolipoprotein C-II (apoCII), apolipoprotein C-III (apoCIII) and apolipoprotein E (apoE).
  
  
  RESULTS
  MFT correlated with apoAII and apoB serum concentrations. The correlations with apoAII and apoB remained significant following correction for BMI. No correlations were noted between MFT and serum apoAI, apoCII, apoCIII or apoE levels before or after adjustment for BMI.
  
  
  CONCLUSIONS
  Our study indicates that MFT is significantly correlated with the concentration of atherogenic low density lipoproteins particles, as well as with apoAII, a determinant of free fatty acids levels. No correlation was observed between mesenteric fat thickness and very low density lipoprotein or chylomicron particles concentration.
authors.affiliation: Laboratory for Experimental Surgery and Surgical Research "N,S, Christeas", University of Athens Medical School, 15b Agiou Thoma Street, Goudi, Athens 11527, Greece. a_perelas@hotmail.com
authors.forename: Apostolos
authors.initials: A
authors.lastname: Perelas
authors.forename: Vanessa
authors.initials: V
authors.lastname: Safarika
authors.forename: Ioannis S
authors.initials: IS
authors.lastname: Vlachos
authors.forename: Irene
authors.initials: I
authors.lastname: Tzanetakou
authors.forename: Laskarina-Maria
authors.initials: LM
authors.lastname: Korou
authors.forename: Panagiotis
authors.initials: P
authors.lastname: Konstantopoulos
authors.forename: Ilias
authors.initials: I
authors.lastname: Doulamis
authors.forename: Ioannis
authors.initials: I
authors.lastname: Ioannidis
authors.forename: Ioannis
authors.initials: I
authors.lastname: Kornezos
authors.forename: Dimitrios
authors.initials: D
authors.lastname: Gargas
authors.forename: Christos
authors.initials: C
authors.lastname: Klonaris
authors.forename: Despina N
authors.initials: DN
authors.lastname: Perrea
authors.forename: Achilleas
authors.initials: A
authors.lastname: Chatziioannou
mesh_terms: D000368:Aged; D001053:Apolipoproteins / Q000097:blood*; D001157:Arterial Occlusive Diseases / Q000097:blood* / Q000000981:diagnostic imaging / Q000473:pathology; D005260:Female; D006801:Humans; D050152:Intra-Abdominal Fat / Q000000981:diagnostic imaging / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D058729:Peripheral Arterial Disease / Q000097:blood* / Q000000981:diagnostic imaging / Q000473:pathology; D014463:Ultrasonography
chemical_list: D001053:Apolipoproteins