title: A new automated NaCl based robust method for routine production of gallium-68 labeled peptides.
abstract: A new NaCl based method for preparation of gallium-68 labeled radiopharmaceuticals has been adapted for use with an automated gallium-68 generator system. The method was evaluated based on 56 preparations of [(68)Ga]DOTATOC and compared to a similar acetone-based approach. Advantages of the new NaCl approach include reduced preparation time (<15 min) and removal of organic solvents. The method produces high peptide-bound % (>97%), and specific activity (>40 MBq nmole(-1) [(68)Ga]DOTATOC) and is well-suited for clinical production of radiopharmaceuticals.
authors.affiliation: Department of Radiology, The University of Iowa, 200 Hawkins Drive, Iowa City, IA 52242, USA.
authors.forename: Michael K
authors.initials: MK
authors.lastname: Schultz
authors.forename: Dirk
authors.initials: D
authors.lastname: Mueller
authors.forename: Richard P
authors.initials: RP
authors.lastname: Baum
authors.forename: G
authors.initials: G
authors.lastname: Leonard Watkins
authors.forename: Wouter A P
authors.initials: WA
authors.lastname: Breeman
mesh_terms: D001331:Automation; D005710:Gallium Radioisotopes; D007553:Isotope Labeling / Q000379:methods*; D015282:Octreotide / Q000031:analogs & derivatives* / Q000138:chemical synthesis; D011876:Radionuclide Generators; D019275:Radiopharmaceuticals / Q000138:chemical synthesis*; D012965:Sodium Chloride; D012984:Software
chemical_list: D005710:Gallium Radioisotopes; D019275:Radiopharmaceuticals; D012965:Sodium Chloride; D015282:Octreotide; C106246:Edotreotide