title: Aortic clamping in pancreas transplantation: is there any harm to the transplanted kidney graft?
abstract: BACKGROUND
  Some special situations may require aortic clamping during pancreas transplantation (PT). The most important problem is ischemic injury to a previous transplanted kidney. We sought to demonstrate experience with aortic clamping in PT without special kidney allograft protection measures and its impact on kidney function.
  
  
  METHODS
  Retrospective study that analyzed 6 patients who underwent PT (5 pancreas after kidney and 1 simultaneous pancreas-kidney) with aortic clamping. In all cases, the pancreas graft was placed on the right with retrocolic portal-enteric drainage. Serum creatinine was evaluated pre- and posttransplantation.
  
  
  RESULTS
  The average clamping time was 19 minutes. The mean serum creatinine was 1.1, 1.15, 0.95, and 1.0, respectively, at pre and postoperative days 1 and 7 and at hospital discharge. Patient, kidney, and pancreatic graft survivals were 100%, 100%, and 83%, respectively.
  
  
  CONCLUSIONS
  The need for aortic clamping in selected cases of PT did not seem to affect the transplanted kidney, even without protective measures, provided that the ischemic time was short.
authors.affiliation: Grupo Hepato and Bandeirantes and Beneficência Portuguesa Hospitals, São Paulo, Brazil. marcelo-perosa@uol.com.br
authors.forename: M P
authors.initials: MP
authors.lastname: Miranda
authors.forename: T
authors.initials: T
authors.lastname: Genzini
authors.forename: H
authors.initials: H
authors.lastname: Noujaim
authors.forename: L T
authors.initials: LT
authors.lastname: Mota
authors.forename: J R
authors.initials: JR
authors.lastname: Branez
authors.forename: L E
authors.initials: LE
authors.lastname: Ianhez
authors.forename: R
authors.initials: R
authors.lastname: Azevedo
authors.forename: E T M
authors.initials: ET
authors.lastname: Shiroma
mesh_terms: D000328:Adult; D001011:Aorta / Q000601:surgery*; D015415:Biomarkers / Q000097:blood; D003250:Constriction; D003404:Creatinine / Q000097:blood; D005260:Female; D006085:Graft Survival; D006801:Humans; D016030:Kidney Transplantation / Q000009:adverse effects; D008297:Male; D008875:Middle Aged; D016035:Pancreas Transplantation / Q000009:adverse effects / Q000379:methods*; D012189:Retrospective Studies; D013997:Time Factors; D016896:Treatment Outcome; D014656:Vascular Surgical Procedures / Q000009:adverse effects; D052096:Warm Ischemia
chemical_list: D015415:Biomarkers; D003404:Creatinine