title: Melatonin levels in periodontal health and disease.
abstract: OBJECTIVE
  The aim of this study was to measure melatonin levels in the gingival crevicular fluid and saliva of subjects with healthy periodontal tissues, plaque-induced gingival inflammation, chronic periodontitis and aggressive periodontitis.
  
  
  METHODS
  A total of 70 subjects were examined and assigned to four groups: healthy periodontium (10 subjects); plaque-induced gingival inflammation (20 subjects); chronic periodontitis (20 subjects); and aggressive periodontitis (20 subjects). Gingival crevicular fluid and saliva samples were collected from each subject and analyzed using ELISAs.
  
  
  RESULTS
  The melatonin levels in both gingival crevicular fluid and saliva were lower in patients with chronic periodontitis (10.4 and 12.8 pg/mL, respectively) and aggressive periodontitis (8.4 and 8.8 pg/mL, respectively) than in patients with gingivitis (13.9 and 17.6 pg/mL, respectively) and in healthy subjects (16.6 and 22.9 pg/mL, respectively). The mean melatonin levels in both gingival crevicular fluid and saliva were statistically significantly higher in healthy patients compared with patients with chronic periodontitis and aggressive periodontitis; however, there was no significant difference in the plaque-induced gingival inflammation between the study groups.
  
  
  CONCLUSIONS
  The melatonin levels in gingival crevicular fluid and saliva are decreased in diseased periodontal tissues, especially periodontitis. The melatonin level was lowest in the aggressive periodontitis group.
authors.affiliation: Department Preventive Dentistry, Periodontics Division, Riyadh Colleges of Dentistry and Pharmacy, Riyadh, Saudi Arabia.
authors.forename: O M
authors.initials: OM
authors.lastname: Almughrabi
authors.forename: K M
authors.initials: KM
authors.lastname: Marzouk
authors.forename: R M
authors.initials: RM
authors.lastname: Hasanato
authors.forename: S S
authors.initials: SS
authors.lastname: Shafik
mesh_terms: D000293:Adolescent; D000328:Adult; D010520:Aggressive Periodontitis / Q000378:metabolism*; D000704:Analysis of Variance; D016022:Case-Control Studies; D055113:Chronic Periodontitis / Q000378:metabolism*; D005260:Female; D005883:Gingival Crevicular Fluid / Q000737:chemistry; D005891:Gingivitis / Q000378:metabolism*; D006801:Humans; D008297:Male; D008550:Melatonin / Q000032:analysis / Q000378:metabolism*; D008875:Middle Aged; D012463:Saliva / Q000737:chemistry; D018709:Statistics, Nonparametric; D055815:Young Adult
chemical_list: D008550:Melatonin