title: Indiacens A and B: prenyl indoles from the myxobacterium Sandaracinus amylolyticus.
abstract: The gliding bacterium Sandaracinus amylolyticus, strain NOSO-4T, was recently characterized as the first representative of a new myxobacterial genus. A screening of the culture broth for antibiotically active metabolites followed by isolation and characterization revealed two unique 3-formylindol derivatives, indiacen A (1) and its chloro derivative indiacen B (2). Both are active against Gram-positive and Gram-negative bacteria as well as the fungus Mucor hiemalis. The biosynthetic origin of the isoprene-like side chain in 1 and 2 was studied by in vivo feeding experiments with ¹³C-labeled precursors.
authors.affiliation: Research Group Microbial Drugs, Helmholtz Centre for Infection Research, Inhoffenstrasse 7, 38124 Braunschweig, Germany.
authors.forename: Heinrich
authors.initials: H
authors.lastname: Steinmetz
authors.forename: Kathrin I
authors.initials: KI
authors.lastname: Mohr
authors.forename: Wiebke
authors.initials: W
authors.lastname: Zander
authors.forename: Rolf
authors.initials: R
authors.lastname: Jansen
authors.forename: Klaus
authors.initials: K
authors.lastname: Gerth
authors.forename: Rolf
authors.initials: R
authors.lastname: Müller
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D006090:Gram-Negative Bacteria / Q000187:drug effects; D006094:Gram-Positive Bacteria / Q000187:drug effects; D007211:Indoles / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D009089:Mucor / Q000187:drug effects; D009231:Myxococcales / Q000737:chemistry*
chemical_list: D000900:Anti-Bacterial Agents; D007211:Indoles; C577819:indiacen A; C577820:indiacen B