title: Association of the DYX1C1 dyslexia susceptibility gene with orthography in the Chinese population.
abstract: Several independent studies have supported the association of DYX1C1 with dyslexia, but its role in general reading development remains unclear. Here, we investigated the contribution of this gene to reading, with a focus on orthographic skills, in a sample of 284 unrelated Chinese children aged 5 to 11 years who were participating in the Chinese Longitudinal Study of Reading Development. We tested this association using a quantitative approach for Chinese character reading, Chinese character dictation, orthographic judgment, and visual skills. Significant or marginally significant associations were observed at the marker rs11629841 with children's orthographic judgments at ages 7 and 8 years (all P values<0.020). Significant associations with Chinese character dictation (all P values<0.013) were also observed for this single-nucleotide polymorphism (SNP) at ages 9, 10, and 11 years. Further analyses revealed that the association with orthographic skills was specific to the processing of specific components of characters (P values<0.046). No association was found at either SNP of rs3743205 or rs57809907. Our findings suggest that DYX1C1 influences reading development in the general Chinese population and supports a universal effect of this gene.
authors.affiliation: State Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University, Beijing, China.
authors.forename: Yuping
authors.initials: Y
authors.lastname: Zhang
authors.forename: Jun
authors.initials: J
authors.lastname: Li
authors.forename: Twila
authors.initials: T
authors.lastname: Tardif
authors.forename: Margit
authors.initials: M
authors.lastname: Burmeister
authors.forename: Sandra M
authors.initials: SM
authors.lastname: Villafuerte
authors.forename: Catherine
authors.initials: C
authors.lastname: McBride-Chang
authors.forename: Hong
authors.initials: H
authors.lastname: Li
authors.forename: Bingjie
authors.initials: B
authors.lastname: Shi
authors.forename: Weilan
authors.initials: W
authors.lastname: Liang
authors.forename: Zhixiang
authors.initials: Z
authors.lastname: Zhang
authors.forename: Hua
authors.initials: H
authors.lastname: Shu
mesh_terms: D044466:Asian People / Q000235:genetics*; D002648:Child; D002675:Child, Preschool; D002681:China; D003598:Cytoskeletal Proteins; D004410:Dyslexia / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D007600:Judgment; D008297:Male; D009419:Nerve Tissue Proteins / Q000235:genetics*; D009687:Nuclear Proteins / Q000235:genetics*; D010641:Phenotype; D020641:Polymorphism, Single Nucleotide; D011932:Reading
chemical_list: D003598:Cytoskeletal Proteins; C478878:DNAAF4 protein, human; D009419:Nerve Tissue Proteins; D009687:Nuclear Proteins