title: Determining how defects in connexin43 cause skeletal disease.
abstract: Gap junction channels mediate direct cell-cell communication via the exchange of second messengers, ions, and metabolites from one cell to another. Mutations in several human connexin (cx) genes, the subunits of gap junction channels, disturb the development and function of multiple tissues/organs. In particular, appropriate function of Cx43 is required for skeletal development in all vertebrate model organisms. Importantly, it remains largely unclear how disruption of gap junctional intercellular communication causes developmental defects. Two groups have taken distinct approaches toward defining the tangible molecular changes occurring downstream of Cx43-based gap junctional communication. Here, these strategies for determining how Cx43 modulates downstream events relevant to skeletal morphogenesis were reviewed.
authors.affiliation: Department of Biological Sciences, 111 Research Drive, Iacocca B217, Lehigh University, Bethlehem, PA, USA.
authors.forename: Quynh V
authors.initials: QV
authors.lastname: Ton
authors.forename: M Kathryn
authors.initials: MK
authors.lastname: Iovine
mesh_terms: D000818:Animals; D001846:Bone Development; D001847:Bone Diseases / Q000235:genetics / Q000378:metabolism; D002450:Cell Communication; D002460:Cell Line; D018031:Connexin 43 / Q000235:genetics* / Q000378:metabolism*; D017629:Gap Junctions / Q000378:metabolism*; D005786:Gene Expression Regulation; D006801:Humans; D009154:Mutation; D010006:Osteoblasts / Q000502:physiology; D014714:Vertebrates
chemical_list: D018031:Connexin 43; C500216:GJA1 protein, human