title: Potent small-molecule suppression of oxacillin resistance in methicillin-resistant Staphylococcus aureus.
abstract: Shields down! Adjuvant molecules that have the ability to restore the susceptibility of multi-drug-resistant bacteria, such as MRSA, to clinically available antibiotics are a promising alternative to the development of novel antimicrobials. Pictured is a potent small molecule (1) that, at sub-minimum inhibitory concentration (sub-MIC) levels, lowers the MIC of oxacillin (2) against a number of MRSA strains by up to 512-fold.
authors.affiliation: Department of Chemistry, North Carolina State University, Raleigh, 27695, USA.
authors.forename: Tyler L
authors.initials: TL
authors.lastname: Harris
authors.forename: Roberta J
authors.initials: RJ
authors.lastname: Worthington
authors.forename: Christian
authors.initials: C
authors.lastname: Melander
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D004351:Drug Resistance; D055624:Methicillin-Resistant Staphylococcus aureus / Q000187:drug effects*; D008826:Microbial Sensitivity Tests; D010068:Oxacillin / Q000494:pharmacology*
chemical_list: D000900:Anti-Bacterial Agents; D010068:Oxacillin