title: Antibiotic and antimalarial quinones from fungus-growing ant-associated Pseudonocardia sp.
abstract: Three new members of the angucycline class of antibiotics, pseudonocardones A-C (1-3), along with the known antibiotics 6-deoxy-8-O-methylrabelomycin (4) and X-14881 E (5) have been isolated from the culture of a Pseudonocardia strain associated with the fungus-growing ant Apterostigma dentigerum. Compounds 4 and 5 showed antibiotic activity against Bacillus subtilis 3610 and liver-stage Plasmodium berghei, while 1-3 were inactive or only weakly active in a variety of biological assays. Compound 5 also showed moderate cytotoxicity against HepG2 cells.
authors.affiliation: Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts 02115, USA.
authors.forename: Gavin
authors.initials: G
authors.lastname: Carr
authors.forename: Emily R
authors.initials: ER
authors.lastname: Derbyshire
authors.forename: Eric
authors.initials: E
authors.lastname: Caldera
authors.forename: Cameron R
authors.initials: CR
authors.lastname: Currie
authors.forename: Jon
authors.initials: J
authors.lastname: Clardy
mesh_terms: D000192:Actinomycetales / Q000737:chemistry*; D000818:Animals; D000852:Anopheles / Q000187:drug effects; D000880:Anthraquinones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D000962:Antimalarials / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D001000:Ants / Q000382:microbiology*; D001412:Bacillus subtilis / Q000187:drug effects; D017173:Caenorhabditis elegans / Q000187:drug effects; D004354:Drug Screening Assays, Antitumor; D004926:Escherichia coli / Q000187:drug effects; D056945:Hep G2 Cells; D006801:Humans; D008099:Liver / Q000382:microbiology; D008826:Microbial Sensitivity Tests; D010962:Plasmodium berghei / Q000187:drug effects; D012441:Saccharomyces cerevisiae / Q000187:drug effects; D034101:Sporozoites / Q000187:drug effects; D013559:Symbiosis
chemical_list: D000880:Anthraquinones; D000900:Anti-Bacterial Agents; D000962:Antimalarials; D000970:Antineoplastic Agents; C577730:pseudonocardone A; C577729:pseudonocardone B; C577731:pseudonocardone C