title: Pd-PEPPSI-IPent(Cl): a highly effective catalyst for the selective cross-coupling of secondary organozinc reagents.
abstract: No migration? No problem! A series of new N-heterocyclic carbene based Pd complexes has been created and evaluated in the Negishi cross-coupling of aryl and heteroaryl chlorides, bromides, and triflates with a variety of secondary alkylzinc reagents. The direct elimination product is nearly exclusively formed; in most examples there is no migratory insertion at all.
authors.affiliation: Department of Chemistry, York University, Toronto, ON, Canada.
authors.forename: Matthew
authors.initials: M
authors.lastname: Pompeo
authors.forename: Robert D J
authors.initials: RD
authors.lastname: Froese
authors.forename: Niloufar
authors.initials: N
authors.lastname: Hadei
authors.forename: Michael G
authors.initials: MG
authors.lastname: Organ
mesh_terms: D002384:Catalysis; D060326:Chemistry Techniques, Synthetic / Q000379:methods*; D015394:Molecular Structure; D009942:Organometallic Compounds / Q000737:chemistry*; D010165:Palladium / Q000737:chemistry*; D013237:Stereoisomerism; D015032:Zinc / Q000737:chemistry
chemical_list: D009942:Organometallic Compounds; D010165:Palladium; D015032:Zinc