title: Intestinal perforated malignant melanoma: diagnostic and therapeutic difficulties.
abstract: The intestinal malignant melanoma is a rare occurrence in the daily surgical practice, with difficult diagnosis (even on usual pathologic examination) and therapeutic attitude. Most of the lesions are secondary to a cutaneous primary melanoma, but there are cases in which the original site may not be discovered, and are considered as primitive intestinal melanomas. This paper presents the case of a 50 year old male patient, diagnosed and operated as emergency with acute abdomen caused by a tumoral perforation of the small bowel; several tumors, in different stages of local evolution, were discovered during laparotomy. A triple enterectomy with end-to-end entero-enteral anastomosis was performed, with uneventful postoperative recovery. The later postoperative evolution was marked by the occurrence of multiple subcutaneous recurrences and a bulky metastasis in the mediastinum; 18 month after the initial surgery, the patient died due to the melanoma recurrence. Diagnostic and therapeutic difficulties are discussed in this paper, related especially to the differential diagnosis of the origin of the intestinal lesion (a metastatic melanoma with unknown primary site or a primary malignant melanoma of the small bowel), since no other sites of origin were discovered after a thorough examination.
authors.affiliation: Surgical Clinic II, University of Medicine and Pharmacy of Craiova, Romania. alina.vilcea@yahoo.com
authors.forename: I D
authors.initials: ID
authors.lastname: Vîlcea
authors.forename: I
authors.initials: I
authors.lastname: Vasile
authors.forename: A M
authors.initials: AM
authors.lastname: Vîlcea
authors.forename: C S
authors.initials: CS
authors.lastname: Mirea
authors.forename: C F
authors.initials: CF
authors.lastname: Popescu
authors.forename: P
authors.initials: P
authors.lastname: Mitrut
mesh_terms: D003937:Diagnosis, Differential; D017809:Fatal Outcome; D005500:Follow-Up Studies; D006801:Humans; D007078:Ileal Neoplasms / Q000150:complications / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery*; D007416:Intestinal Perforation / Q000175:diagnosis* / Q000209:etiology / Q000473:pathology / Q000601:surgery*; D007580:Jejunal Neoplasms / Q000150:complications / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery*; D008297:Male; D008545:Melanoma / Q000150:complications / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery*; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D017211:Treatment Failure; D016896:Treatment Outcome