title: Palladium-catalyzed regioselective [3 + 2] annulation of internal alkynes and iodo-pyranoquinolines with concomitant ring opening.
abstract: A regioselective tandem synthesis of highly functionalized pyrrolo[1,2-a]quinolines has been developed through a novel strategy by palladium-catalyzed [3 + 2] annulation of iodo-pyranoquinolines and internal alkynes with subsequent ring opening. Pyranoquinoline with n-alkyl substitution at the 3-position leads to the formation of pyrrolo-acridones via [3 + 2] annulations/ring opening and successive intramolecular cross-aldol condensation.
authors.affiliation: Department of Chemistry, University of Delhi, Delhi, 110007, India.
authors.forename: Trapti
authors.initials: T
authors.lastname: Aggarwal
authors.forename: Rajeev R
authors.initials: RR
authors.lastname: Jha
authors.forename: Rakesh K
authors.initials: RK
authors.lastname: Tiwari
authors.forename: Sonu
authors.initials: S
authors.lastname: Kumar
authors.forename: Siva K Reddy
authors.initials: SK
authors.lastname: Kotla
authors.forename: Sushil
authors.initials: S
authors.lastname: Kumar
authors.forename: Akhilesh K
authors.initials: AK
authors.lastname: Verma
mesh_terms: D000480:Alkynes / Q000737:chemistry*; D002384:Catalysis; D007211:Indoles / Q000737:chemistry*; D015394:Molecular Structure; D010165:Palladium / Q000737:chemistry*; D011804:Quinolines / Q000737:chemistry*
chemical_list: D000480:Alkynes; D007211:Indoles; D011804:Quinolines; D010165:Palladium; C030374:indole