title: The Role of Helicobacter pylori and NSAIDs in the Pathogenesis of Uncomplicated Duodenal Ulcer.
abstract: Background/Aim. To identify the etiological role of Helicobacter pylori (Hp) and nonsteroidal anti-inflammatory drugs (NSAIDs) in endoscopically diagnosed duodenal ulcers (DUs). Methods. Patients undergoing esophagogastroduodenoscopy in two major hospitals in Antalya and Adiyaman were included in this study and assigned as duodenal ulcer (n = 152; median age: 41.0 (16-71) years; 58.6% males) or control group (n = 70; median age: 41.0 (18-68) years; 57.1% males). Patient demographics, risk factors, and NSAID/acetylsalicylic acid (ASA) use were recorded. Results. HP was more commonly located in the corpus (75.0 versus 50.0%; odds ratio [OR] = 3.00; 95% confidence interval [CI]: 1.66-5.44; P < 0.001), incisura (75.7 versus 60.0%; OR = 2.07; 95% CI: 1.13-3.79; P = 0.017), and antrum (80.3 versus 60.0%; OR = 2.71; 95% CI: 1.45-5.05; P = 0.001) among DU patients than controls. Hp positivity was 84.9% while Hp was negative in 15.1% of patients including those accompanied with NSAID and/or ASA use (9.2%), and those were negative for all three etiological factors (5.9%). Conclusion. Our findings indicate the substantial role of Hp in the pathogenesis of DU disease as identified in 84.9% of DU patients compatible with the background prevalence of 61.4% among age-matched control subjects. Hp was the single causative factor in 44.1% of our patients, while NSAID/ASA exposure was in 9.2%.
authors.affiliation: Department of Gastroenterology, Antalya Training and Research Hospital, 07050 Antalya, Turkey.
authors.forename: Ayhan Hilmi
authors.initials: AH
authors.lastname: Cekin
authors.forename: Muharrem
authors.initials: M
authors.lastname: Taskoparan
authors.forename: Adil
authors.initials: A
authors.lastname: Duman
authors.forename: Cem
authors.initials: C
authors.lastname: Sezer
authors.forename: Yesim
authors.initials: Y
authors.lastname: Cekin
authors.forename: Basak Oguz
authors.initials: BO
authors.lastname: Yolcular
authors.forename: Hasan
authors.initials: H
authors.lastname: Can
authors.forename: Fatma Seher
authors.initials: FS
authors.lastname: Pehlivan
authors.forename: Mine
authors.initials: M
authors.lastname: Cayirci