title: Missing links? - The connection between replication and movement of plant RNA viruses.
abstract: Plant virus infection spreads from cell-to-cell within the host with the aid of viral movement proteins (MPs) that transport infectious genomes through intercellular pores called plasmodesmata (PD). MPs are able to accomplish RNA trafficking independent of virus infection. However, although dispensable for replication, they often associate with or assist in the formation of viral replication complexes. Quantitative analyses of genetic bottlenecks during infection, as well as considerations of transport specificity, suggest that intricate links between replication and movement may facilitate efficient delivery of plant viruses through PD during early infection, at a stage when viral genomes are still rare.
authors.affiliation: Biomedical Sciences Research Complex, University of St Andrews, North Haugh, St Andrews, Fife KY16 9ST, United Kingdom. jt58@st-andrews.ac.uk
authors.forename: Jens
authors.initials: J
authors.lastname: Tilsner
authors.forename: Karl J
authors.initials: KJ
authors.lastname: Oparka
mesh_terms: D053830:Plant Viral Movement Proteins / Q000378:metabolism*; D010942:Plant Viruses / Q000472:pathogenicity / Q000502:physiology*; D010944:Plants / Q000821:virology; D031425:Plasmodesmata / Q000378:metabolism / Q000821:virology; D012328:RNA Viruses / Q000472:pathogenicity / Q000502:physiology*; D012367:RNA, Viral / Q000378:metabolism*; D014779:Virus Replication
chemical_list: D053830:Plant Viral Movement Proteins; D012367:RNA, Viral