title: [Clinical research on Sanmiao powder combined fibrinogenase for injection in treatment of acute deep venous thrombosis of lower limbs].
abstract: OBJECTIVE
  To observe the clinical effectiveness of Sanmiao Powder (SP) combined fibrinogenase for injection in treatment of acute deep venous thrombosis (ADVT) of lower limbs.
  
  
  METHODS
  Eighty patients with ADVT were randomly assigned to two groups according to the disease course (within 7 days or 7-28 days), 40 in each group. Every time phase was also divided into two groups, i. e., one group treated with fibrinogenase for injection alone (Group A and C) and another group treated with fibrinogenase for injection + SP administration (Group B and D) , 20 in each group. The clinical effectiveness was observed after 2-week treatment.
  
  
  RESULTS
  The fibrinogenase for injection + SP administration showed better effects in alleviating the swelling of limbs, relieving pain, and lowering fibrinogen. Better effects were obtained in the group with the disease course less than 7 days.
  
  
  CONCLUSIONS
  Better effect on ADVT was obtained by integrative medicine.
authors.affiliation: Department of Angiopathy, Second Hospital of Shandong University, Jinan. doctorzhou6677@hotmail.com
authors.forename: Tao
authors.initials: T
authors.lastname: Zhou
authors.forename: Da-Qing
authors.initials: DQ
authors.lastname: Sun
authors.forename: Peng
authors.initials: P
authors.lastname: Wu
mesh_terms: D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D035002:Lower Extremity / Q000098:blood supply; D008297:Male; D008666:Metalloendopeptidases / Q000627:therapeutic use*; D008875:Middle Aged; D008517:Phytotherapy; D020246:Venous Thrombosis / Q000188:drug therapy*
chemical_list: D004365:Drugs, Chinese Herbal; D008666:Metalloendopeptidases