title: Sesquiterpenes and neolignans from the roots of Illicium dunnianum.
abstract: Two new sesquiterpenes, dunnianoside I (1) and 8'-oxo-6-hydroxy-dihydrophaseic acid methyl ester (2), a new glycoside, dunnianoside J (3), two new neolignans, dunnianeolignans A-B (4, 5), together with 10 known compounds (6-15), were isolated from the roots of Illicium dunnianum. The structures of these new compounds were elucidated by spectroscopic methods including 1D and 2D NMR, HR-ESI-MS, and chemical methods. Compounds 7, 8, and 13-15 exhibited potent antioxidant activities against Fe²⁺-cystine-induced rat liver microsomal lipid peroxidation, with IC₅₀ values ranging from 4.2 ± 0.4 to 38.4 ± 2.6 μM.
authors.affiliation: State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China.
authors.forename: Jian
authors.initials: J
authors.lastname: Bai
authors.forename: Hui
authors.initials: H
authors.lastname: Chen
authors.forename: Zhen-Feng
authors.initials: ZF
authors.lastname: Fang
authors.forename: Shi-Shan
authors.initials: SS
authors.lastname: Yu
authors.forename: Shuang-Gang
authors.initials: SG
authors.lastname: Ma
authors.forename: Yong
authors.initials: Y
authors.lastname: Li
authors.forename: Jing
authors.initials: J
authors.lastname: Qu
authors.forename: Song
authors.initials: S
authors.lastname: Xu
authors.forename: Jing-Hong
authors.initials: JH
authors.lastname: Ren
authors.forename: Hai-Ning
authors.initials: HN
authors.lastname: Lü
authors.forename: Xia
authors.initials: X
authors.lastname: Chen
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D006027:Glycosides / Q000737:chemistry / Q000302:isolation & purification*; D029523:Illicium / Q000737:chemistry*; D017705:Lignans / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D015227:Lipid Peroxidation / Q000187:drug effects; D008315:Malondialdehyde / Q000032:analysis; D008862:Microsomes, Liver / Q000737:chemistry / Q000187:drug effects; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D018517:Plant Roots / Q000737:chemistry; D051381:Rats; D012717:Sesquiterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology
chemical_list: C577523:8'-oxo-6-hydroxy-dihydrophaseic acid methyl ester; D000975:Antioxidants; D004365:Drugs, Chinese Herbal; D006027:Glycosides; D017705:Lignans; D012717:Sesquiterpenes; C577521:dunnianeolignan A; C577522:dunnianeolignan B; C577519:dunnianoside I; C577520:dunnianoside J; D008315:Malondialdehyde