title: MicroRNAs and HIV-1: complex interactions.
abstract: RNAi plays important roles in many biological processes, including cellular defense against viral infection. Components of the RNAi machinery are widely conserved in plants and animals. In mammals, microRNAs (miRNAs) represent an abundant class of cell encoded small noncoding RNAs that participate in RNAi-mediated gene silencing. Here, findings that HIV-1 replication in cells can be regulated by miRNAs and that HIV-1 infection of cells can alter cellular miRNA expression are reviewed. Lessons learned from and questions outstanding about the complex interactions between HIV-1 and cellular miRNAs are discussed.
authors.affiliation: Molecular Virology Section, Laboratory of Molecular Microbiology, NIAID, National Institutes of Health, Bethesda, Maryland 20892, USA.
authors.forename: Zachary
authors.initials: Z
authors.lastname: Klase
authors.forename: Laurent
authors.initials: L
authors.lastname: Houzet
authors.forename: Kuan-Teh
authors.initials: KT
authors.lastname: Jeang
mesh_terms: D000818:Animals; D060565:Argonaute Proteins / Q000378:metabolism; D015496:CD4-Positive T-Lymphocytes / Q000821:virology; D053487:DEAD-box RNA Helicases / Q000378:metabolism; D015967:Gene Expression Regulation, Viral; D020868:Gene Silencing; D015497:HIV-1 / Q000235:genetics*; D006367:HeLa Cells; D006801:Humans; D035683:MicroRNAs / Q000378:metabolism*; D008954:Models, Biological; D034622:RNA Interference; D012323:RNA Processing, Post-Transcriptional; D034741:RNA, Small Interfering / Q000378:metabolism*; D012367:RNA, Viral / Q000378:metabolism; D043244:Ribonuclease III / Q000378:metabolism
chemical_list: D060565:Argonaute Proteins; D035683:MicroRNAs; D034741:RNA, Small Interfering; D012367:RNA, Viral; C408087:DICER1 protein, human; D043244:Ribonuclease III; D053487:DEAD-box RNA Helicases