title: Age- and gender-specific associations between low serum 25-hydroxyvitamin D level and type 2 diabetes in the Korean general population: analysis of 2008-2009 Korean National Health and Nutrition Examination Survey data.
abstract: BACKGROUND
  We present data from the Korean National Health and Nutritional Examination Survey (KNHANES) 2008-2009 on the association between 25-hydroxyvitamin D[25(OH)D] status and type 2 diabetes in a representative sample of the adult Korean population.
  
  
  METHODS
  This study was based on data obtained from the KNHANES 2008-2009, which was conducted for 3 years (2007-2009) using a rolling sampling design that involved a complex, stratified, multistage, probability-cluster survey of a representative sample of the noninstitutionalized civilian population of South Korea.
  
  
  RESULTS
  We showed that serum 25(OH)D concentration is inversely associated with type 2 diabetes in the Korean general population. In particular, low serum 25(OH)D concentration was associated with an increased prevalence of type 2 diabetes in young women and old men. The present study showed that 25(OH)D has a significant negative association with fasting insulin and insulin resistance.
  
  
  CONCLUSIONS
  The age- and gender-specific association between low 25(OH)D level and type 2 diabetes may be related to interactions between vitamin D, sex hormone concentrations, and type 2 diabetes. In conclusion, we showed that low 25(OH)D concentration is associated with type 2 diabetes in the Korean general population in an age- and gender-specific pattern.
authors.affiliation: Institute of Environmental and Occupational Medicine, Soonchunhyang University, South Korea.
authors.forename: Byung-Kook
authors.initials: BK
authors.lastname: Lee
authors.forename: Sunmin
authors.initials: S
authors.lastname: Park
authors.forename: Yangho
authors.initials: Y
authors.lastname: Kim
mesh_terms: D015652:25-Hydroxyvitamin D 2 / Q000097:blood*; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000208:ethnology; D002112:Calcifediol / Q000097:blood*; D003430:Cross-Sectional Studies; D003924:Diabetes Mellitus, Type 2 / Q000097:blood* / Q000453:epidemiology / Q000208:ethnology / Q000209:etiology*; D005260:Female; D006306:Health Surveys; D006801:Humans; D007328:Insulin / Q000097:blood; D007333:Insulin Resistance; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D056910:Republic of Korea / Q000453:epidemiology; D012737:Sex Factors; D014808:Vitamin D Deficiency / Q000097:blood* / Q000453:epidemiology / Q000208:ethnology / Q000503:physiopathology*; D055815:Young Adult
chemical_list: D007328:Insulin; D015652:25-Hydroxyvitamin D 2; D002112:Calcifediol