title: [Angioid streaks].
abstract: Angioid streaks represent breaks in Bruch's membrane, appearing as dark or reddish radial streaks eminating from the optic disc. Usually asymptomatic, these streaks may develop neovascularisation and lead to a maculopathy with marked loss of vision. Some associations with systemic disease are classically described, especially pseudoxanthoma elasticum. This condition may involve cardiovascular complications. A mutation has been found in the ABCC6 gene, which encodes for a membrane transport protein involved in the synthesis of the extracellular matrix. Imaging allows for visualization of the extent of the streaks, and autofluorescence is particularly informative. Spectral domain OCT may also demonstrate early breaks in Bruch's membrane. Neovascular complications, previously responsible for inevitable visual impairment at some point after their occurrence, are now managed by intravitreal injections of anti-VEGFs with clear efficacity. The ophthalmologist must be aware of this condition, in order to guide the patient towards a systemic work-up if necessary, and also to insure quick and targeted treatment in the case of neovascular complications.
authors.affiliation: Service d'ophtalmologie, hôpital Nord, chemin des Bourrelys, 13015 Marseille, France.
authors.forename: F
authors.initials: F
authors.lastname: Matonti
authors.forename: J
authors.initials: J
authors.lastname: Conrath
mesh_terms: D000793:Angioid Streaks / Q000150:complications / Q000175:diagnosis / Q000209:etiology / Q000628:therapy; D016570:Bruch Membrane / Q000473:pathology; D020256:Choroidal Neovascularization / Q000150:complications; D005130:Eye Hemorrhage / Q000150:complications / Q000209:etiology; D006453:Hemoglobinopathies / Q000150:complications; D006801:Humans; D011561:Pseudoxanthoma Elasticum / Q000150:complications; D012422:Rupture, Spontaneous / Q000150:complications