title: Pulmonary-type adenocarcinoma and signet ring mucinous adenocarcinoma arising in an ovarian dermoid cyst: report of a unique case.
abstract: Dermoid cysts are common benign ovarian germ cell neoplasms. Occasionally, one of the mature elements undergoes malignant transformation resulting in the formation of a somatic malignancy; most commonly this is squamous carcinoma. We report a unique case where 2 separate malignancies arose within a dermoid cyst, one a signet ring mucinous adenocarcinoma and the other a pulmonary-type adenocarcinoma. There have been only occasional earlier case reports of a possible pulmonary-type adenocarcinoma arising in a dermoid cyst. In the case we report, the pulmonary-type adenocarcinoma was closely associated with a bronchial structure and exhibited diffuse positive immunohistochemical staining with TTF1, PE10, and napsin A. Molecular studies revealed no evidence of epidermal growth factor receptor mutation, a molecular alteration which may be found in primary pulmonary adenocarcinoma.
authors.affiliation: Department of Pathology, Belfast Health and Social Care Trust and Molecular Pathology Programme, Centre for Cancer Research and Cell Biology, Queens University Belfast, BT12 6BA Belfast, UK.
authors.forename: Clinton
authors.initials: C
authors.lastname: Boyd
authors.forename: Kaushik
authors.initials: K
authors.lastname: Patel
authors.forename: Brendan
authors.initials: B
authors.lastname: O'Sullivan
authors.forename: Philippe
authors.initials: P
authors.lastname: Taniere
authors.forename: W Glenn
authors.initials: WG
authors.lastname: McCluggage
mesh_terms: D002288:Adenocarcinoma, Mucinous / Q000150:complications / Q000378:metabolism / Q000473:pathology*; D000328:Adult; D014408:Biomarkers, Tumor / Q000378:metabolism; D018279:Carcinoma, Signet Ring Cell / Q000150:complications / Q000378:metabolism / Q000473:pathology*; D004252:DNA Mutational Analysis; D004273:DNA, Neoplasm / Q000032:analysis; D066246:ErbB Receptors / Q000235:genetics; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000150:complications / Q000378:metabolism / Q000473:pathology*; D009378:Neoplasms, Multiple Primary; D010051:Ovarian Neoplasms / Q000150:complications / Q000378:metabolism / Q000473:pathology*; D010052:Ovariectomy; D013724:Teratoma / Q000150:complications / Q000378:metabolism / Q000473:pathology*
chemical_list: D014408:Biomarkers, Tumor; D004273:DNA, Neoplasm; C512478:EGFR protein, human; D066246:ErbB Receptors