title: Antimicrobial and antifouling hydrogels formed in situ from polycarbonate and poly(ethylene glycol) via Michael addition.
abstract: A novel class of antimicrobial cationic polycarbonate/PEG hydrogels are designed and synthesized by Michael addition chemistry. These hydrogels demonstrate strong broad-spectrum antimicrobial activities against various clinically isolated multidrug-resistant microbes. Moreover, they exhibit nonfouling properties and prevent the substrate from microbial adhesion. These antimicrobial and antifouling gels are promising materials as catheter coatings and wound dressings to prevent infections.
authors.affiliation: Institute of Bioengineering and Nanotechnology, 31 Biopolis Way, Singapore 138669, Singapore.
authors.forename: Shao Qiong
authors.initials: SQ
authors.lastname: Liu
authors.forename: Chuan
authors.initials: C
authors.lastname: Yang
authors.forename: Yuan
authors.initials: Y
authors.lastname: Huang
authors.forename: Xin
authors.initials: X
authors.lastname: Ding
authors.forename: Yan
authors.initials: Y
authors.lastname: Li
authors.forename: Wei Min
authors.initials: WM
authors.lastname: Fan
authors.forename: James L
authors.initials: JL
authors.lastname: Hedrick
authors.forename: Yi-Yan
authors.initials: YY
authors.lastname: Yang
mesh_terms: D000900:Anti-Bacterial Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D057219:Biofouling / Q000517:prevention & control*; D002176:Candida albicans / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D004926:Escherichia coli / Q000187:drug effects; D020100:Hydrogels / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D008958:Models, Molecular; D015394:Molecular Structure; D011076:Polycarboxylate Cement / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D011092:Polyethylene Glycols / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D013211:Staphylococcus aureus / Q000187:drug effects; D013329:Structure-Activity Relationship
chemical_list: D000900:Anti-Bacterial Agents; D020100:Hydrogels; D011076:Polycarboxylate Cement; C005506:polycarbonate; D011092:Polyethylene Glycols