title: Antibody responses to norovirus genogroup GI.1 and GII.4 proteases in volunteers administered Norwalk virus.
abstract: An assay was developed to detect antibodies against two norovirus proteases among participants in a Norwalk virus (GI.1) challenge study. Prechallenge seroprevalence was lower against the protease from the homologous GI.1 virus than against protease from a heterologous GII.4 strain. Seroresponses were detected for 14 of 19 (74%) infected persons.
authors.affiliation: Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, Texas, USA.
authors.forename: Nadim J
authors.initials: NJ
authors.lastname: Ajami
authors.forename: Meagan A
authors.initials: MA
authors.lastname: Barry
authors.forename: Berenice
authors.initials: B
authors.lastname: Carrillo
authors.forename: Zana
authors.initials: Z
authors.lastname: Muhaxhiri
authors.forename: Frederick H
authors.initials: FH
authors.lastname: Neill
authors.forename: B V Venkataram
authors.initials: BV
authors.lastname: Prasad
authors.forename: Antone R
authors.initials: AR
authors.lastname: Opekun
authors.forename: Mark A
authors.initials: MA
authors.lastname: Gilger
authors.forename: David Y
authors.initials: DY
authors.lastname: Graham
authors.forename: Robert L
authors.initials: RL
authors.lastname: Atmar
authors.forename: Mary K
authors.initials: MK
authors.lastname: Estes
mesh_terms: D000328:Adult; D000914:Antibodies, Viral / Q000097:blood*; D000917:Antibody Formation; D000956:Antigens, Viral / Q000276:immunology*; D006805:Human Experimentation; D006801:Humans; D007118:Immunoassay / Q000379:methods; D009663:Norwalk virus / Q000276:immunology*; D010447:Peptide Hydrolases / Q000276:immunology*
chemical_list: D000914:Antibodies, Viral; D000956:Antigens, Viral; D010447:Peptide Hydrolases