title: [Clinical observation of Compound Zhebei Granule in improving the survival time of refractory acute leukemia patients].
abstract: OBJECTIVE
  To observe the effects of Compound Zhebei Granule (CZG) as the main intervention and treatment protocol on the sustained remission time, the median survival time, the relapse rate, and the mortality rate of refractory acute leukemia (RAL) patients.
  
  
  METHODS
  The RAL subjects, who were completely released after one standard chemotherapeutic course of the National Support Scheme (Chinese medicine interventions and standard chemotherapy of Western medicine in the peri-chemotherapy) were followed-up to get knowledge of the sustained remission time, the survival time, the relapse rate, and the morbidity.
  
  
  RESULTS
  Totally 41 patients were finally accounted into the statistics, 20 in the treatment group and 21 in the control group. The sustained remission time was 172 days in the treatment group and 115 days in the control group, the median survival time was 363 days and 201 days respectively. The relapse rate of the treatment group within 3 months, 6 months,1 year, and the total relapse rate was 30.0%, 50.0%, 70.0%, and 90.0%, respectively, lower than that of the control group (being 42.8%, 76.2%, 90.5%, 90.5%, respectively). The mortality rate of the treatment group was 80.0%, 5.7% lower than that of the control group (85.7%).
  
  
  CONCLUSIONS
  CZG could lengthen the sustained remission time for RAL patients, elevate their survival time, and reduce the relapse rate and the mortality rate.
authors.affiliation: Department of Oncology and Hematology, Dongzhimen Hospital Affiliated to Belling University of Chinese Medicine, Beijing.
authors.forename: Dong-Yun
authors.initials: DY
authors.lastname: Li
authors.forename: Shan
authors.initials: S
authors.lastname: Huang
authors.forename: Xin-Yi
authors.initials: XY
authors.lastname: Chen
mesh_terms: D000208:Acute Disease; D000328:Adult; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D007938:Leukemia / Q000188:drug therapy* / Q000401:mortality*; D008297:Male; D008875:Middle Aged; D008517:Phytotherapy; D012074:Remission Induction; D015996:Survival Rate; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D004365:Drugs, Chinese Herbal