title: Association study of DRD2 and MAOA genes with subtyped alcoholism comorbid with bipolar disorder in Han Chinese.
abstract: BACKGROUND
  Several studies have hypothesized that genes involved in the dopamine system, including dopamine type-2 receptor (DRD2)-related TaqIA polymorphism and monoamine oxidase-A upstream variable number tandem repeat (uVNTR), may be associated with alcoholism. But their results were contradictory because of alcoholism's heterogeneity. Therefore, we examined whether the DRD2TaqIA and MAOA-uVNTR gene polymorphisms are susceptibility factors for alcoholism comorbid with bipolar disorder (ALC+BP) in Han Chinese in Taiwan.
  
  
  METHODS
  We recruited 101 Han Chinese men with comorbid alcoholism and bipolar disorder, and 328 healthy male controls from the community. Genotyping was done using PCR-RFLP.
  
  
  RESULTS
  There were no significant differences in the genotypic frequencies of the DRD2TaqIA or the MAOA-uVNTR polymorphisms between the 2 groups. The MAOA-uVNTR 3-repeat had a significant protective effect on the ALC+BP (odds ratio=0.432, p=0.035) but not on the healthy controls. However, the interaction between the MAOA-uVNTR 3-repeat and DRD2 A1/A2 was a risk factor in the ALC+BP (odds ratio=3.451, p=0.018).
  
  
  CONCLUSIONS
  We indicated the impact of the association between MAOA-uVNTR 3-repeat and DRD2 A1/A2 with ALC+BP.
authors.affiliation: Institute of Behavioral Medicine, National Cheng Kung University, Tainan, Taiwan.
authors.forename: Ming-Chuan
authors.initials: MC
authors.lastname: Hu
authors.forename: Sheng-Yu
authors.initials: SY
authors.lastname: Lee
authors.forename: Tzu-Yun
authors.initials: TY
authors.lastname: Wang
authors.forename: Shiou-Lan
authors.initials: SL
authors.lastname: Chen
authors.forename: Yun-Hsuan
authors.initials: YH
authors.lastname: Chang
authors.forename: Shih-Heng
authors.initials: SH
authors.lastname: Chen
authors.forename: Chun-Hsien
authors.initials: CH
authors.lastname: Chu
authors.forename: Chen-Lin
authors.initials: CL
authors.lastname: Wang
authors.forename: I Hui
authors.initials: IH
authors.lastname: Lee
authors.forename: Tzung Lieh
authors.initials: TL
authors.lastname: Yeh
authors.forename: Yen Kuang
authors.initials: YK
authors.lastname: Yang
authors.forename: Ru-Band
authors.initials: RB
authors.lastname: Lu
mesh_terms: D000328:Adult; D000437:Alcoholism / Q000453:epidemiology / Q000235:genetics*; D000483:Alleles; D044466:Asian People / Q000235:genetics; D001714:Bipolar Disorder / Q000453:epidemiology / Q000235:genetics*; D002681:China / Q000453:epidemiology; D015897:Comorbidity; D005787:Gene Frequency; D056726:Genetic Association Studies; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D008995:Monoamine Oxidase / Q000235:genetics*; D011110:Polymorphism, Genetic; D017448:Receptors, Dopamine D2 / Q000235:genetics*
chemical_list: D017448:Receptors, Dopamine D2; D008995:Monoamine Oxidase