title: Metabolic impacts of high dietary exposure to persistent organic pollutants in mice.
abstract: Persistent organic pollutants (POPs) have been linked to metabolic diseases. Yet, the effects of high exposure to dietary POPs remain unclear. We therefore investigated whether elevated exposure to POPs provided by whale meat supplementation could contribute to insulin resistance. C57BL/6J mice were fed control (C) or very high-fat diet (VHF) containing low or high levels of POPs (VHF(+POPs)) for eight weeks. To elevate the dietary concentrations of POPs, casein was replaced by whale meat containing high levels of pollutants. Feeding VHF(+POPs) induced high POP accumulation in the adipose tissue of mice. However, compared with VHF-fed mice, animals fed VHF(+POPs) had improved insulin sensitivity and glucose tolerance, and reduced body weight. Levels of ectopic fat in skeletal muscles and liver were reduced in mice fed VHF(+POPs). These mice also gained less adipose tissue and had a tendency to reduced energy intake. In pair-feeding experiments, improved insulin action and reduced body weight gain were still observed in VHF(+POPs) compared to VHF pair-fed mice. We concluded that mice fed VHF contaminated with POPs derived from whale meat remain sensitive to insulin and glucose tolerant despite significant body burden of POPs. This indicates complex interactions between organic pollutants and nutrition in the development of metabolic disorders.
authors.affiliation: National Institute of Nutrition and Seafood Research, Postboks, Bergen, Norway.
authors.forename: Mohammad Madani
authors.initials: MM
authors.lastname: Ibrahim
authors.forename: Even
authors.initials: E
authors.lastname: Fjære
authors.forename: Erik-Jan
authors.initials: EJ
authors.lastname: Lock
authors.forename: Livar
authors.initials: L
authors.lastname: Frøyland
authors.forename: Niels
authors.initials: N
authors.lastname: Jessen
authors.forename: Sten
authors.initials: S
authors.lastname: Lund
authors.forename: Hubert
authors.initials: H
authors.lastname: Vidal
authors.forename: Jérôme
authors.initials: J
authors.lastname: Ruzzin
mesh_terms: D000818:Animals; D001822:Body Burden; D004032:Diet; D059305:Diet, High-Fat / Q000009:adverse effects; D004041:Dietary Fats / Q000378:metabolism; D002149:Energy Intake / Q000502:physiology; D004785:Environmental Pollutants / Q000633:toxicity*; D005947:Glucose / Q000378:metabolism; D018149:Glucose Intolerance / Q000139:chemically induced / Q000378:metabolism; D005951:Glucose Tolerance Test; D007333:Insulin Resistance; D007408:Intestinal Absorption; D008099:Liver / Q000378:metabolism; D008297:Male; D008460:Meat; D008659:Metabolic Diseases / Q000139:chemically induced* / Q000378:metabolism; D051379:Mice; D008810:Mice, Inbred C57BL; D018482:Muscle, Skeletal / Q000378:metabolism; D009930:Organic Chemicals / Q000633:toxicity; D014280:Triglycerides / Q000378:metabolism; D014907:Whales
chemical_list: D004041:Dietary Fats; D004785:Environmental Pollutants; D009930:Organic Chemicals; D014280:Triglycerides; D005947:Glucose