title: EEG-vigilance regulation during the resting state in obsessive-compulsive disorder.
abstract: OBJECTIVE
  Obsessive compulsive disorder (OCD) has been associated with disturbed sleep-wake cycles and cortical hypermetabolism. However, it still remains unclear whether OCD is associated with a dysregulation of vigilance (i.e. "brain arousal"). VIGALL (Vigilance Algorithm Leipzig) is an EEG-based tool to assess vigilance dynamics. Aim of this study is to test the hypothesis that during resting state less declines to lower vigilance stages are found in unmedicated patients with OCD (n=30) compared to healthy controls (HCs, n=30).
  
  
  METHODS
  Fifteen minutes of resting EEG were recorded; preceding sleep duration, nicotine/caffeine consumption and severity of OCD and depressive symptoms were assessed.
  
  
  RESULTS
  Significant differences of EEG-vigilance were found for the factor "group" (OCD vs. HC), factor "time" and interaction "group×time" in a repeated measures ANOVA with increased EEG-vigilance in OCD patients. OCD patients showed significantly fewer transitions between EEG-vigilance stages.
  
  
  CONCLUSIONS
  In line with findings of disturbed sleep regulation, OCD is associated with altered EEG-vigilance regulation with a failure of declining toward low vigilance stages during rest.
  
  
  CONCLUSIONS
  These results encourage the use of EEG-vigilance regulation for determining subgroups for e.g. studying treatment response and suggest awareness for possible vigilance effects in neuroimaging studies of OCD.
authors.affiliation: Clinic for Psychiatry and Psychotherapy, University Hospital Leipzig, Germany. Sebastian.Olbrich@medizin.uni-leipzig.de
authors.forename: Sebastian
authors.initials: S
authors.lastname: Olbrich
authors.forename: Hanife
authors.initials: H
authors.lastname: Olbrich
authors.forename: Ina
authors.initials: I
authors.lastname: Jahn
authors.forename: Christian
authors.initials: C
authors.lastname: Sander
authors.forename: Michael
authors.initials: M
authors.lastname: Adamaszek
authors.forename: Ulrich
authors.initials: U
authors.lastname: Hegerl
authors.forename: Fred
authors.initials: F
authors.lastname: Reque
authors.forename: Katarina
authors.initials: K
authors.lastname: Stengler
mesh_terms: D000328:Adult; D001143:Arousal / Q000502:physiology; D002540:Cerebral Cortex / Q000503:physiopathology*; D004569:Electroencephalography; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009771:Obsessive-Compulsive Disorder / Q000503:physiopathology*; D012720:Severity of Illness Index; D012890:Sleep / Q000502:physiology*