title: C2-Alkylation of N-pyrimidylindole with vinylsilane via cobalt-catalyzed C-H bond activation.
abstract: Direct C2-alkylation of an indole bearing a readily removable N-pyrimidyl group with a vinylsilane was achieved by using a cobalt catalyst generated in situ from CoBr(2), bathocuproine, and cyclohexylmagnesium bromide. The reaction allows coupling between a series of N-pyrimidylindoles and vinylsilanes at a mild reaction temperature of 60 °C, affording the corresponding alkylated indoles in moderate to good yields.
authors.affiliation: Division of Chemistry and Biological Chemistry, School of Physical and Mathematical Sciences, Nanyang Technological University, Singapore 637371, Singapore.
authors.forename: Zhenhua
authors.initials: Z
authors.lastname: Ding
authors.forename: Naohiko
authors.initials: N
authors.lastname: Yoshikai