title: Prevention of disuse muscle atrophy by dietary ingestion of 8-prenylnaringenin in denervated mice.
abstract: Flavonoids have attracted considerable attention in relation to their effects upon health. 8-Prenylnaringenin (8-PN) is found in the common hop (Humulus lupulus) and assumed to be responsible for the health impact of beer consumption. We wanted to clarify the effects of prenylation on the physiological functions of dietary flavonoids by comparing the effects of 8-PN with that of intact naringenin in the prevention of disuse muscle atrophy using a model of denervation in mice. Consumption of 8-PN (but not naringenin) prevented loss of weight in the gastrocnemius muscle further supported by the lack of induction of the protein content of a key ubiquitin ligase involved in muscle atrophy, atrogin-1, and by the activation of Akt phosphorylation. 8-PN content in the gastrocnemius muscle was tenfold higher than that of naringenin. These results suggested that, compared with naringenin, 8-PN was effectively concentrated into skeletal muscle to exert its preventive effects upon disuse muscle atrophy. It is likely that prenylation generates novel functions for 8-PN by enhancing its accumulation into muscle tissue through dietary intake.
authors.affiliation: Department of Food Science, Institute of Health Biosciences, University of Tokushima Graduate School, Tokushima, Japan.
authors.forename: Rie
authors.initials: R
authors.lastname: Mukai
authors.forename: Hitomi
authors.initials: H
authors.lastname: Horikawa
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Fujikura
authors.forename: Tomoyuki
authors.initials: T
authors.lastname: Kawamura
authors.forename: Hisao
authors.initials: H
authors.lastname: Nemoto
authors.forename: Takeshi
authors.initials: T
authors.lastname: Nikawa
authors.forename: Junji
authors.initials: J
authors.lastname: Terao
mesh_terms: D000818:Animals; D002460:Cell Line; D002851:Chromatography, High Pressure Liquid; D004032:Diet; D044950:Flavanones / Q000008:administration & dosage / Q000737:chemistry / Q000493:pharmacokinetics / Q000627:therapeutic use*; D027582:Humulus / Q000737:chemistry; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D009121:Muscle Denervation; D018485:Muscle Fibers, Skeletal / Q000378:metabolism; D018482:Muscle, Skeletal / Q000294:innervation* / Q000473:pathology; D009133:Muscular Atrophy / Q000188:drug therapy* / Q000517:prevention & control*; D020966:Muscular Disorders, Atrophic / Q000188:drug therapy* / Q000517:prevention & control*; D010766:Phosphorylation; D011208:Powders; D051057:Proto-Oncogene Proteins c-akt / Q000378:metabolism; D014867:Water
chemical_list: C119737:8-prenylnaringenin; D044950:Flavanones; D011208:Powders; D014867:Water; D051057:Proto-Oncogene Proteins c-akt