title: MicroRNA-330 is an oncogenic factor in glioblastoma cells by regulating SH3GL2 gene.
abstract: MicroRNAs have recently emerged as key regulators of cancers. This study was therefore conducted to investigate the role of miR-330 in biological behaviors of human glioblastoma U87 and U251 cell lines and its molecular mechanism. SH3GL2 gene was identified as the target of miR-330. MiR-330 overexpression was established by transfecting miR-330 precursor into U87 and U251 cells, and its effects on proliferation, migration, invasion, cell cycle and apoptosis were studied. Overexpression of miR-330 can enhance cellular proliferation, promote migration and invasion, activate cell cycle and also inhibit apoptosis in U87 and U251 cells. Collectively, these above-mentioned results suggest that miRNA-330 plays an oncogenic role in human glioblastoma by regulating SH3GL2 gene and might be a new therapeutic target of human glioblastoma.
authors.affiliation: Department of Neurosurgery, Shengjing Hospital of China Medical University, Shenyang, People's Republic of China.
authors.forename: Shengtao
authors.initials: S
authors.lastname: Qu
authors.forename: Yilong
authors.initials: Y
authors.lastname: Yao
authors.forename: Chao
authors.initials: C
authors.lastname: Shang
authors.forename: Yixue
authors.initials: Y
authors.lastname: Xue
authors.forename: Jun
authors.initials: J
authors.lastname: Ma
authors.forename: Zhen
authors.initials: Z
authors.lastname: Li
authors.forename: Yunhui
authors.initials: Y
authors.lastname: Liu
mesh_terms: D048868:Adaptor Proteins, Signal Transducing / Q000235:genetics*; D017209:Apoptosis; D001483:Base Sequence; D001921:Brain / Q000378:metabolism / Q000473:pathology; D001932:Brain Neoplasms / Q000235:genetics* / Q000473:pathology; D002453:Cell Cycle; D045744:Cell Line, Tumor; D002465:Cell Movement; D049109:Cell Proliferation; D015972:Gene Expression Regulation, Neoplastic; D005909:Glioblastoma / Q000235:genetics* / Q000473:pathology; D006801:Humans; D035683:MicroRNAs / Q000235:genetics*
chemical_list: D048868:Adaptor Proteins, Signal Transducing; C570805:MIRN330 microRNA, human; D035683:MicroRNAs; C107640:SH3GL2 protein, human