title: Moderate-intensity physical activity ameliorates the breast cancer risk in diabetic women.
abstract: OBJECTIVE
  To evaluate the association between self-reported diabetes and the risk of breast cancer (BC) and its interaction with moderate-intensity physical activity in pre- and postmenopausal Mexican women.
  
  
  METHODS
  A population-based case-control study was conducted using 1,000 incident case subjects and 1,074 control subjects. Blood samples and information on health, diet, physical activity, and anthropometric measurements were obtained.
  
  
  RESULTS
  The association between diabetes and BC risk decreased with increasing tertiles of moderate-intensity physical activity (odds ratio [OR] = 4.9 [95% CI 2.3-10.8]; 3.0 [1.3-6.9]; and 1.0 [0.1-9.2], respectively, for each tertile) (test for interaction = 0.04). Compared with the women in the lowest tertiles, increased risk was observed in those premenopausal women with the highest serum C-peptide, IGF-1, and IGF-1 binding protein 3 levels.
  
  
  CONCLUSIONS
  Moderate-intensity physical activity can substantially ameliorate the increased BC risk in diabetic women.
authors.affiliation: Institute of Public Health, Center for Population Health Research, Cuernavaca, Morelos, Mexico.
authors.forename: Gabriela
authors.initials: G
authors.lastname: Torres-Mejía
authors.forename: Angélica
authors.initials: A
authors.lastname: Angeles-Llerenas
authors.forename: Carolina
authors.initials: C
authors.lastname: Ortega-Olvera
authors.forename: Eduardo
authors.initials: E
authors.lastname: Lazcano-Ponce
authors.forename: Elad
authors.initials: E
authors.lastname: Ziv
authors.forename: José
authors.initials: J
authors.lastname: Pulido-Rodríguez
authors.forename: Manuel de Jesús
authors.initials: Mde J
authors.lastname: García-Solis
authors.forename: Efrén
authors.initials: E
authors.lastname: Murillo-Zamora
authors.forename: Julia
authors.initials: J
authors.lastname: Vázquez-Lara
authors.forename: Isabelle
authors.initials: I
authors.lastname: Romieu
mesh_terms: D001943:Breast Neoplasms / Q000097:blood* / Q000453:epidemiology*; D002096:C-Peptide / Q000097:blood; D016022:Case-Control Studies; D015444:Exercise / Q000502:physiology*; D005260:Female; D006801:Humans; D018972:Insulin-Like Growth Factor Binding Protein 3 / Q000097:blood; D007334:Insulin-Like Growth Factor I / Q000378:metabolism; D016017:Odds Ratio; D017698:Postmenopause / Q000097:blood; D017697:Premenopause / Q000097:blood
chemical_list: D002096:C-Peptide; D018972:Insulin-Like Growth Factor Binding Protein 3; D007334:Insulin-Like Growth Factor I