title: Impact of age on epidermal growth factor receptor mutation in lung cancer.
abstract: Aging is one of the best, but rarely referred, risk factors for various types of cancer including lung cancer, because age could be a surrogate for accumulation of genetic events in cancers. Smoking inversely associates with the presence of epidermal growth factor receptor (EGFR) mutation in lung cancer, but its strong confounding with age and sex makes it difficult to evaluate sole impact of age. To clarify an impact of age on EGFR mutation, we conducted a cross-sectional study based on data of 1262 lung cancer patients. The associations between EGFR mutation and age, considering sex, smoking and histology, were evaluated using logistic regression models. In multivariate analysis, we found a significant increase of EGFR mutation prevalence by increase of age (p-trend=0.0004). Consistent trend was observed among never-smoking females (p-trend=0.011) and never-smoking males also showed similar trend although not significant. These were consistently observed when we limit the subject to those with adenocarcinoma. In conclusion, age independently associates with EGFR mutation among lung cancer. Positive association between EGFR mutation and age among never-smokers regardless of sex might indicate that EGFR mutation occurs cumulatively by unidentified internal/external factors other than smoking.
authors.affiliation: Department of Thoracic Surgery, Okayama University Hospital, Okayama, Japan.
authors.forename: Tsuyoshi
authors.initials: T
authors.lastname: Ueno
authors.forename: Shinichi
authors.initials: S
authors.lastname: Toyooka
authors.forename: Kenichi
authors.initials: K
authors.lastname: Suda
authors.forename: Junichi
authors.initials: J
authors.lastname: Soh
authors.forename: Yasushi
authors.initials: Y
authors.lastname: Yatabe
authors.forename: Shinichiro
authors.initials: S
authors.lastname: Miyoshi
authors.forename: Keitaro
authors.initials: K
authors.lastname: Matsuo
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Mitsudomi
mesh_terms: D000230:Adenocarcinoma / Q000209:etiology / Q000235:genetics*; D000328:Adult; D000367:Age Factors; D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000209:etiology / Q000235:genetics*; D003430:Cross-Sectional Studies; D004252:DNA Mutational Analysis; D066246:ErbB Receptors / Q000235:genetics*; D005260:Female; D056726:Genetic Association Studies; D006801:Humans; D008175:Lung Neoplasms / Q000209:etiology / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D020125:Mutation, Missense; D012307:Risk Factors; D017384:Sequence Deletion; D012907:Smoking / Q000009:adverse effects
chemical_list: D066246:ErbB Receptors