title: Nano hydroxyapatite-coated implants improve bone nanomechanical properties.
abstract: Nanostructure modification of dental implants has long been sought as a means to improve osseointegration through enhanced biomimicry of host structures. Several methods have been proposed and demonstrated for creating nanotopographic features; here we describe a nanoscale hydroxyapatite (HA)-coated implant surface and hypothesize that it will hasten osseointegration and improve its quality relative to that of non-coated implants. Twenty threaded titanium alloy implants, half prepared with a stable HA nanoparticle surface and half grit-blasted, acid-etched, and heat-treated (HT), were inserted into rabbit femurs. Pre-operatively, the implants were morphologically and topographically characterized. After 3 weeks of healing, the samples were retrieved for histomorphometry. The nanomechanical properties of the surrounding bone were evaluated by nanoindentation. While both implants revealed similar bone-to-implant contact, the nanoindentation demonstrated that the tissue quality was significantly enhanced around the HA-coated implants, validating the postulated hypothesis.
authors.affiliation: Department of Prosthodontics, Faculty of Odontology, Malmö University, Sweden. ryo.jimbo@mah.se
authors.forename: R
authors.initials: R
authors.lastname: Jimbo
authors.forename: P G
authors.initials: PG
authors.lastname: Coelho
authors.forename: M
authors.initials: M
authors.lastname: Bryington
authors.forename: M
authors.initials: M
authors.lastname: Baldassarri
authors.forename: N
authors.initials: N
authors.lastname: Tovar
authors.forename: F
authors.initials: F
authors.lastname: Currie
authors.forename: M
authors.initials: M
authors.lastname: Hayashi
authors.forename: M N
authors.initials: MN
authors.lastname: Janal
authors.forename: M
authors.initials: M
authors.lastname: Andersson
authors.forename: D
authors.initials: D
authors.lastname: Ono
authors.forename: S
authors.initials: S
authors.lastname: Vandeweghe
authors.forename: A
authors.initials: A
authors.lastname: Wennerberg
mesh_terms: D000818:Animals; D001696:Biomechanical Phenomena; D020099:Coated Materials, Biocompatible / Q000008:administration & dosage* / Q000737:chemistry; D003722:Dental Alloys / Q000737:chemistry; D015921:Dental Implants; D017267:Dental Prosthesis Design; D006882:Hydroxyapatites / Q000008:administration & dosage* / Q000737:chemistry; D008422:Materials Testing; D053758:Nanoparticles / Q000008:administration & dosage* / Q000737:chemistry; D016348:Osseointegration / Q000187:drug effects / Q000502:physiology*; D011817:Rabbits; D013499:Surface Properties; D013977:Tibia / Q000187:drug effects / Q000601:surgery / Q000648:ultrastructure
chemical_list: D020099:Coated Materials, Biocompatible; D003722:Dental Alloys; D015921:Dental Implants; D006882:Hydroxyapatites