title: Genetic polymorphism of PRKCDBP is associated with an increased risk of endometrial cancer.
abstract: PRKCDBP is a putative tumor suppressor located at 11p15.4, where frequent genomic loss has been observed in human cancers. We explored the possible association between an intra-exonic single nucleotide polymorphism (SNP), rs1051992, that results in a Leu to Pro substitution, and risk for endometrial carcinogenesis. We assessed the genotype of rs1051992 in endometrial cancer tissues from 147 patients and normal endometrial tissue from 191 healthy individuals by restriction endonuclease PvuII-based genotyping. Allele frequencies in the cancer specimens were compared with those in the healthy controls. We also evaluated the association between polymorphisms at this locus and histopathological features of endometrial cancer.
authors.affiliation: Department of Obstetrics and Gynecology, School of Medicine, Kyung Hee University, Seoul, South Korea.
authors.forename: Seo-Yun
authors.initials: SY
authors.lastname: Tong
authors.forename: Jong-Min
authors.initials: JM
authors.lastname: Lee
authors.forename: Kyung-Do
authors.initials: KD
authors.lastname: Ki
authors.forename: Hyun-Joo
authors.initials: HJ
authors.lastname: Seol
authors.forename: Young-Joon
authors.initials: YJ
authors.lastname: Choi
authors.forename: Seon-Kyung
authors.initials: SK
authors.lastname: Lee
mesh_terms: D000328:Adult; D019943:Amino Acid Substitution; D016889:Endometrial Neoplasms / Q000235:genetics* / Q000473:pathology; D004717:Endometrium / Q000473:pathology; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D047908:Intracellular Signaling Peptides and Proteins / Q000235:genetics*; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors
chemical_list: C505360:CAVIN3 protein, human; D047908:Intracellular Signaling Peptides and Proteins