title: [Death domain-associated protein (DAXX)-mediated regulation of transcription and cell death].
abstract: Death domain-associated protein (DAXX) is a multifunctional protein that modulates both cell death and transcription. DAXX predominantly localizes in the nucleus and regulates the transcription of genes. Several studies have indicated that DAXX is a mediator of lymphocyte death and/or growth suppression, although it is still unclear whether DAXX pro-cell death function is dependent on its transcriptional functions. We found that DAXX suppresses the gp130/STAT3-dependent cell growth and that DAXX interacts with STAT3 and inhibits its DNA-binding activity. Here we will discuss recent developments in our understanding of the nuclear functions of DAXX.
authors.affiliation: Department of Immunology, Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo, Japan. muro@pharm.hokudai.ac.jp
authors.forename: Ryuta
authors.initials: R
authors.lastname: Muromoto
mesh_terms: D048868:Adaptor Proteins, Signal Transducing / Q000502:physiology*; D016923:Cell Death / Q000502:physiology*; D056970:Co-Repressor Proteins; D015850:Interleukin-6 / Q000502:physiology; D008214:Lymphocytes / Q000502:physiology; D018832:Molecular Chaperones; D009687:Nuclear Proteins / Q000502:physiology*; D014158:Transcription, Genetic / Q000502:physiology*
chemical_list: D048868:Adaptor Proteins, Signal Transducing; D056970:Co-Repressor Proteins; C106985:DAXX protein, human; D015850:Interleukin-6; D018832:Molecular Chaperones; D009687:Nuclear Proteins