title: Case report of hepatic mucormycosis after liver transplantation: successful treatment with liposomal amphotericin B followed by posaconazole sequential therapy.
abstract: Mucormycosis is a rare but emerging fungal infection complicating solid organ transplantation (SOT), with a cumulative incidence of around 2% during the first year after SOT. The associated mortality rate is high, and surgical debridement is frequently required as part of the treatment along with antifungal therapy based mostly on amphotericin B formulations, We describe here an unusual case of hepatic mucormycosis in a liver transplant recipient that was successfully treated with clinical therapy based on liposomal amphotericin B followed by posaconazole, without surgical resection.
authors.affiliation: Serviço de Controle de Infecção Hospitalar e Seção Médica de Infectologia, Institute Dante Pazzanese de Cardiologia, São Paulo, Brazil. cely.saad@gmail.com
authors.forename: C S
authors.initials: CS
authors.lastname: Abboud
authors.forename: M D
authors.initials: MD
authors.lastname: Bergamasco
authors.forename: C E S
authors.initials: CE
authors.lastname: Baía
authors.forename: M P
authors.initials: MP
authors.lastname: Lallée
authors.forename: A S C
authors.initials: AS
authors.lastname: Zan
authors.forename: M M
authors.initials: MM
authors.lastname: Zamorano
authors.forename: O I
authors.initials: OI
authors.lastname: Pereira
authors.forename: S
authors.initials: S
authors.lastname: Mies
mesh_terms: D000666:Amphotericin B / Q000008:administration & dosage*; D000935:Antifungal Agents / Q000008:administration & dosage*; D004334:Drug Administration Schedule; D005260:Female; D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects; D008107:Liver Diseases / Q000175:diagnosis / Q000188:drug therapy* / Q000382:microbiology; D016031:Liver Transplantation / Q000009:adverse effects*; D009091:Mucormycosis / Q000175:diagnosis / Q000188:drug therapy* / Q000382:microbiology; D013997:Time Factors; D016896:Treatment Outcome; D014230:Triazoles / Q000008:administration & dosage*; D055815:Young Adult
chemical_list: D000935:Antifungal Agents; D007166:Immunosuppressive Agents; D014230:Triazoles; C068538:liposomal amphotericin B; C101425:posaconazole; D000666:Amphotericin B