title: A DNA based five-state switch with programmed reversibility.
abstract: A programmable switch based on a DNA hairpin loop is functionalised with a rigid or flexible porphyrin or FAM and TAMRA FRET pair, which provides insight into the restructuring of the hairpin as well as porphyrin-porphyrin coupling. The switch contains five discrete states which can be accessed independently and followed by real-time spectroscopy, opening the way to a quinary computing code.
authors.affiliation: School of Chemistry, University of Southampton, Highfield, Southampton SO17 1BJ, UK.
authors.forename: Jonathan R
authors.initials: JR
authors.lastname: Burns
authors.forename: Søren
authors.initials: S
authors.lastname: Preus
authors.forename: Daniel G
authors.initials: DG
authors.lastname: Singleton
authors.forename: Eugen
authors.initials: E
authors.lastname: Stulz
mesh_terms: D004247:DNA / Q000737:chemistry*; D031541:Fluorescence Resonance Energy Transfer; D055029:Inverted Repeat Sequences; D011166:Porphyrins / Q000737:chemistry; D012235:Rhodamines / Q000737:chemistry
chemical_list: C114557:5-carboxytetramethylrhodamine succinimidyl ester; D011166:Porphyrins; D012235:Rhodamines; D004247:DNA