title: Methotrexate as an alternative treatment for orbital angiolymphoid hyperplasia with eosinophilia.
abstract: Angiolymphoid hyperplasia with eosinophilia (ALHE) is an uncommon, benign disorder that presents as solitary or multiple nodules in the dermis or subcutaneous tissue. Orbital ALHE has been reported on occasion. We report a case of orbital ALHE which was refractory to systemic steroids but effectively treated with low-dose subcutaneous methotrexate. To our knowledge, this is the first reported case of methotrexate as a successful treatment for refractory ALHE.
authors.affiliation: Department of Ophthalmology and Visual Sciences University of Iowa Hospitals and Clinics, Iowa City, IA, USA.
authors.forename: Meredith S
authors.initials: MS
authors.lastname: Baker
authors.forename: Robert B
authors.initials: RB
authors.lastname: Avery
authors.forename: Courtney R
authors.initials: CR
authors.lastname: Johnson
authors.forename: Richard C
authors.initials: RC
authors.lastname: Allen
mesh_terms: D000293:Adolescent; D000796:Angiolymphoid Hyperplasia with Eosinophilia / Q000175:diagnosis / Q000188:drug therapy*; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use*; D008727:Methotrexate / Q000627:therapeutic use*; D009916:Orbital Diseases / Q000175:diagnosis / Q000188:drug therapy*
chemical_list: D007166:Immunosuppressive Agents; D008727:Methotrexate