title: The MHC2TA gene polymorphisms are not associated with restenosis after coronary stenting in Mexican patients.
abstract: OBJECTIVE
  The aim of this study was to test for association between MHC2TA gene polymorphisms and risk for restenosis after coronary stent placement in a group of Mexican patients.
  
  
  METHODS
  The MHC2TA-168A>G (rs3087456), 1614C>G (rs4774), and 2536G>A (rs2229320) single nucleotide polymorphisms were genotyped using 5' exonuclease TaqMan genotyping assays in a group of 202 patients, who underwent coronary artery stenting. Basal and procedure coronary angiography were analyzed, looking for angiographic predictors of restenosis and follow-up angiography was performed to screen for binary restenosis.
  
  
  RESULTS
  The results obtained in this study showed that the frequency of the three polymorphisms studied was similar in patients with and without restenosis. Univariate analysis showed that the use of drug-eluting stent (DES) reduces the risk of developing restenosis (p<0.001, OR=0.26). In contrast, the diameter<2.5mm of the stent and bifurcations increased the risk of developing restenosis (p=0.049, OR=1.74 and p=0.041, OR=1.8).
  
  
  CONCLUSIONS
  The present study suggests that the MHC2TA polymorphisms are not involved in the risk of developing restenosis after coronary stent placement.
authors.affiliation: Interventional Genetic Study Group in Cardiovascular Disease's, National Institute of Cardiology Ignacio Chávez, Mexico City, Mexico.
authors.forename: Hilda
authors.initials: H
authors.lastname: Delgadillo
authors.forename: Gilberto
authors.initials: G
authors.lastname: Vargas-Alarcón
authors.forename: Omar
authors.initials: O
authors.lastname: Gómez-Monterrosas
authors.forename: Nancy
authors.initials: N
authors.lastname: Martínez-Rodríguez
authors.forename: Silvestre
authors.initials: S
authors.lastname: Ramírez-Fuentes
authors.forename: Silvia
authors.initials: S
authors.lastname: Carrillo-Sánchez
authors.forename: Marco Antonio
authors.initials: MA
authors.lastname: Peña-Duque
authors.forename: Marco Antonio
authors.initials: MA
authors.lastname: Martínez-Ríos
authors.forename: Oscar
authors.initials: O
authors.lastname: Pérez-Méndez
authors.forename: José Manuel
authors.initials: JM
authors.lastname: Fragoso
mesh_terms: D023903:Coronary Restenosis / Q000235:genetics*; D005260:Female; D006801:Humans; D008297:Male; D008800:Mexico; D008875:Middle Aged; D009687:Nuclear Proteins / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D015607:Stents; D015534:Trans-Activators / Q000235:genetics*
chemical_list: C083728:MHC class II transactivator protein; D009687:Nuclear Proteins; D015534:Trans-Activators