title: Selective RNA versus DNA G-quadruplex targeting by in situ click chemistry.
abstract: It all clicks into place: A potent telomere-targeting small molecule has been identified by using the copper-free 1,3-dipolar cycloaddition of a series of alkyne and azide building blocks catalyzed by a non-Watson-Crick DNA secondary structure (see picture). This method rapidly identifies, otherwise unanticipated, potent small-molecule probes to selectively target a given RNA or DNA.
authors.affiliation: University of Cambridge, Department of Chemistry, Lensfield Road, Cambridge, CB2 1EW, UK.
authors.forename: Marco
authors.initials: M
authors.lastname: Di Antonio
authors.forename: Giulia
authors.initials: G
authors.lastname: Biffi
authors.forename: Angelica
authors.initials: A
authors.lastname: Mariani
authors.forename: Eun-Ang
authors.initials: EA
authors.lastname: Raiber
authors.forename: Raphaël
authors.initials: R
authors.lastname: Rodriguez
authors.forename: Shankar
authors.initials: S
authors.lastname: Balasubramanian
mesh_terms: D000480:Alkynes / Q000737:chemistry*; D001386:Azides / Q000737:chemistry*; D057930:Click Chemistry; D004247:DNA / Q000737:chemistry*; D005347:Fibroblasts / Q000166:cytology; D054856:G-Quadruplexes; D006801:Humans; D008856:Microscopy, Fluorescence; D015394:Molecular Structure; D012313:RNA / Q000737:chemistry*; D016615:Telomere / Q000737:chemistry
chemical_list: D000480:Alkynes; D001386:Azides; D012313:RNA; D004247:DNA