title: TBX2 expression is regulated by PAX3 in the melanocyte lineage.
abstract: The paired box homeotic gene 3 (PAX3) is a crucial regulator for the maintenance of melanocytic progenitor cells and has a poorly defined role in melanoma. To understand how PAX3 affects melanocyte and melanoma proliferation, we identified potential PAX3 downstream targets through gene expression profiling. Here, we identify T-box 2 (TBX2), a key developmental regulator of cell identity and an antisenescence factor in melanoma, as a directly regulated PAX3 target. We also found that TBX2 is involved in the survival of melanoma cells and is overexpressed in some melanoma specimens. The identification of TBX2 as a target for PAX3 provides a key insight into how PAX3 may contribute to melanoma evolution and may provide opportunities for prosenescence therapeutic intervention aimed at disrupting the ability of PAX3 to regulate TBX2.
authors.affiliation: Department of Dermatology, Boston University School of Medicine, Boston, MA, USA.
authors.forename: Fang
authors.initials: F
authors.lastname: Liu
authors.forename: Juxiang
authors.initials: J
authors.lastname: Cao
authors.forename: Jinghu
authors.initials: J
authors.lastname: Lv
authors.forename: Liang
authors.initials: L
authors.lastname: Dong
authors.forename: Eric
authors.initials: E
authors.lastname: Pier
authors.forename: George X
authors.initials: GX
authors.lastname: Xu
authors.forename: Rui-an
authors.initials: RA
authors.lastname: Wang
authors.forename: Zhixiang
authors.initials: Z
authors.lastname: Xu
authors.forename: Colin
authors.initials: C
authors.lastname: Goding
authors.forename: Rutao
authors.initials: R
authors.lastname: Cui
mesh_terms: D000818:Animals; D019070:Cell Lineage / Q000235:genetics; D049109:Cell Proliferation; D002470:Cell Survival / Q000235:genetics; D047369:Chromatin Immunoprecipitation; D005786:Gene Expression Regulation; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D008544:Melanocytes / Q000378:metabolism* / Q000473:pathology; D008545:Melanoma / Q000235:genetics / Q000473:pathology; D051379:Mice; D020411:Oligonucleotide Array Sequence Analysis; D000072041:PAX3 Transcription Factor; D051761:Paired Box Transcription Factors / Q000378:metabolism*; D011401:Promoter Regions, Genetic / Q000235:genetics; D011485:Protein Binding / Q000235:genetics; D020825:T-Box Domain Proteins / Q000235:genetics* / Q000378:metabolism; D015854:Up-Regulation / Q000235:genetics
chemical_list: D000072041:PAX3 Transcription Factor; C489409:PAX3 protein, human; D051761:Paired Box Transcription Factors; C097348:T-Box Domain Protein 2; D020825:T-Box Domain Proteins; C068686:Pax3 protein, mouse