title: [Transfusion in children with sickle cell disease].
abstract: Sickle cell disease is a genetic hemoglobinopathy characterised by vasoocclusive events and chronic haemolytic anaemia. Transfusion is a major therapeutic modality in this disease by decreasing the percentage of abnormal haemoglobin Hb S while increasing oxygen carrying capacity. Simple transfusions or exchange transfusions can be indicated occasionally or on a chronic transfusion program. Iron overload, vascular access and alloimmunization to erythrocyte antigens are causes of great concern in these young patients.
authors.affiliation: Service d'hématologie pédiatrique, CHU de Nantes, 7, quai Moncousu, 44093 Nantes cedex 1, France. marielaure.couec@chu-nantes.fr
authors.forename: M-L
authors.initials: ML
authors.lastname: Couëc
mesh_terms: D000755:Anemia, Sickle Cell / Q000628:therapy*; D001803:Blood Transfusion; D002648:Child; D006801:Humans