title: Lack of significant association between Helicobacter pylori infection and homocysteine levels in patients with cardiac syndrome X.
abstract: BACKGROUND
  Helicobacter pylori (H.pylori) has been implicated in the pathogenesis of several diseases such as cardiac syndrome X (CSX), which includes chest pain, positive exercise stress test and normal angiography. Also, elevation of homocysteine (Hcy) level is associated with CSX, as it can severely disturb vascular endothelial function. We aimed to elucidate whether the infection of H.pylori affect the level of Hcy in CSX.
  
  
  METHODS
  Eighty-eight patients with CSX (32 men, 56 women; mean age: 53.8 ± 11.9) and 97 healthy controls (36 men, 61 women; mean age: 45.7 ± 7.3) were enrolled. Plasma samples were tested for the presence of IgG antibody to H.pylori using enzyme linked immunosorbent assay method. Hcy levels were measured enzymatically.
  
  
  RESULTS
  Plasma Hcy concentration in CSX patients is higher than control group (13.1 ± 2.6 vs. 11.8 ± 2.5 mmol/L; p = 0.002). There was no significant difference between Hcy in H.pylori(+) and H.pylori(-) individuals in CSX group (13.1 ± 2.7 vs. 12.2 ± 0.6 mmol/L; p = 0.554) and between two groups in controls, respectively (12.1 ± 2.2 vs. 11.4 ± 2.9 mmol/L; p = 0.148).
  
  
  CONCLUSIONS
  Although there is Hcy level increase in H.pylori(+) CSX patients and controls comparing to H.pylori(-) subjects, but other factors may affect on Hcy level, too. (Cardiol J 2012; 19, 5: 466-469).
authors.affiliation: Center for Cellular and Molecular Research, Urmia University of Medical Sciences, Urmia, Iran. rasmiy@umsu.ac.ir
authors.forename: Yousef
authors.initials: Y
authors.lastname: Rasmi
authors.forename: Kamal
authors.initials: K
authors.lastname: Mehraban
authors.forename: Masoud
authors.initials: M
authors.lastname: Sadreddini
authors.forename: Javad
authors.initials: J
authors.lastname: Zeynalzadeh
authors.forename: Maryam
authors.initials: M
authors.lastname: Majidinia
authors.forename: MirHossein
authors.initials: M
authors.lastname: Seyyed-Mohammadzad
authors.forename: Homayoon
authors.initials: H
authors.lastname: Babazadeh
mesh_terms: D000328:Adult; D000368:Aged; D000907:Antibodies, Bacterial / Q000097:blood; D015415:Biomarkers / Q000097:blood; D016022:Case-Control Studies; D016009:Chi-Square Distribution; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D016481:Helicobacter Infections / Q000097:blood / Q000150:complications* / Q000175:diagnosis / Q000382:microbiology; D016480:Helicobacter pylori / Q000276:immunology* / Q000302:isolation & purification*; D006710:Homocysteine / Q000097:blood*; D006801:Humans; D020138:Hyperhomocysteinemia / Q000097:blood / Q000150:complications* / Q000175:diagnosis; D007074:Immunoglobulin G / Q000097:blood; D008297:Male; D017566:Microvascular Angina / Q000097:blood / Q000175:diagnosis / Q000209:etiology* / Q000382:microbiology; D008875:Middle Aged; D015854:Up-Regulation
chemical_list: D000907:Antibodies, Bacterial; D015415:Biomarkers; D007074:Immunoglobulin G; D006710:Homocysteine