title: Clinical implementation of chromosomal microarray technology in prenatal diagnosis. (Review).
abstract: Chromosomal microarray technology represents the technical convergence of             molecular genetics and cytogenetics, and is rapidly revolutionizing modern cytogenetics.             Expected genomic aberrations are accurately identified and provide readily interpretable             results that are suitable for clinical risk stratification and therapeutic strategies.             The application of array technology in prenatal genetic diagnosis provides distinct             advantages over conventional cytogenetic analysis in detecting both the majority             of microscopic and submicroscopic chromosomal abnormalities. In the last few years,             the validity of array technology has become obvious to medical and laboratory             communities involved in prenatal diagnostic testing. However, whether or not microarray             analysis is sufficient for the detection of cytogenetic abnormalities in prenatal             diagnosis and if traditional cytogenetics continue to be important in this new             era has yet to be confirmed. In the present study, we systematically reviewed             the current status of microarray technology in the identification of pathogenic             genomic imbalances and discussed practical considerations for its routine implementation             in prenatal diagnosis.
authors.affiliation: Department of Biomedical Laboratory Science, Korea Nazarene University,                     Cheonan 331-718, Republic of Korea.
authors.forename: Ji Un
authors.initials: JU
authors.lastname: Kang
authors.forename: Sun Hoe
authors.initials: SH
authors.lastname: Koo
mesh_terms: D002869:Chromosome Aberrations; D002875:Chromosomes / Q000235:genetics*; D020732:Cytogenetic Analysis; D005260:Female; D006801:Humans; D020411:Oligonucleotide Array Sequence Analysis; D011247:Pregnancy; D011296:Prenatal Diagnosis