title: CHD1L protein is overexpressed in human ovarian carcinomas and is a novel predictive biomarker for patients survival.
abstract: BACKGROUND
  Our recent studies suggested that the chromodomain helicase DNA binding protein 1-like (CHD1L) gene plays an oncogenic role in human hepatocellular carcinoma. However, the status of CHD1L protein expression in ovarian cancer and its clinical/prognostic significance are obscure.
  
  
  METHODS
  In this study, immunohistochemistry (IHC) for CHD1L was performed on a tissue microarray (TMA) containing 102 primary ovarian carcinomas and 44 metastatic lesions (omental metastasis). Receiver-operator curve (ROC) analysis was used to evaluate patients' survival status.
  
  
  RESULTS
  There is an augmented tendency of CHD1L expression in ovarian carcinoma metastasis than in primary lesions (P<0.05). A significant association was found between positive expression of CHD1L and tumors histological type (P <0.05). By univariate survival analysis of the ovarian carcinoma cohorts, positive expression of CHD1L was significantly correlated with shortened patient survival (mean 66.7 months versus 97.4 months, P<0.05). Moreover, CHD1L expression was evaluated to be a significant and independent prognostic factor in multivariate analysis (P<0.05).
  
  
  CONCLUSIONS
  These findings provide evidence that positive expression of CHD1L protein is significantly correlated with the metastasis proceeding of ovarian carcinoma, and CHD1L protein expression, as examined by IHC, may act as a novel prognostic biomarker for patients with ovarian carcinoma.
authors.affiliation: Department of Gynecology, the First Affiliated Hospital, Sun Yat-Sen University, No, 78, Zhongshan Road II, 510080 Guangzhou, China.
authors.forename: Wei-Peng
authors.initials: WP
authors.lastname: He
authors.forename: Juan
authors.initials: J
authors.lastname: Zhou
authors.forename: Mu-Yan
authors.initials: MY
authors.lastname: Cai
authors.forename: Xiang-Shen
authors.initials: XS
authors.lastname: Xiao
authors.forename: Yi-Ji
authors.initials: YJ
authors.lastname: Liao
authors.forename: Hsiang-Fu
authors.initials: HF
authors.lastname: Kung
authors.forename: Xin-Yuan
authors.initials: XY
authors.lastname: Guan
authors.forename: Dan
authors.initials: D
authors.lastname: Xie
authors.forename: Guo-Fen
authors.initials: GF
authors.lastname: Yang
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000378:metabolism*; D002277:Carcinoma / Q000378:metabolism* / Q000401:mortality; D015331:Cohort Studies; D004265:DNA Helicases / Q000378:metabolism*; D004268:DNA-Binding Proteins / Q000378:metabolism*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D046228:Microarray Analysis; D008875:Middle Aged; D015999:Multivariate Analysis; D010051:Ovarian Neoplasms / Q000378:metabolism* / Q000401:mortality; D011237:Predictive Value of Tests; D012372:ROC Curve; D016019:Survival Analysis; D055815:Young Adult
chemical_list: D014408:Biomarkers, Tumor; D004268:DNA-Binding Proteins; D004265:DNA Helicases; C543585:CHD1L protein, human