title: All-cause and cardiovascular mortality risk estimation using different definitions of metabolic syndrome in Lithuanian urban population.
abstract: OBJECTIVE
  The objective of the study was to assess mortality risk in the subjects with diagnosed metabolic syndrome (MS) using National Cholesterol Educational Program (NCEP-ATPIII), American Heart Association and National Heart Lung and Blood Institute (AHA/NHLBI) International Diabetes Federation (IDF) and Joint Interim Societies (JIS) definitions.
  
  
  METHODS
  Two random samples aged 35-64 years were examined in 1992-2002 in the framework within the Multinational Monitoring of Trends and Determinants in Cardiovascular Disease (MONICA) study (N=2455). The follow-up was carried out in terms of the end points reached from the baseline health examinations until December 31, 2009.
  
  
  RESULTS
  Cox regressions demonstrated that MS defined by IDF and JIS definitions remained the only significant determinants for all-cause mortality (RR=1.48 and RR=1.41; p<0.05) and cardiovascular disease (CVD) mortality in men (RR=1.81 and RR=1.66; p<0.05). In men (without previous CVD) the NCEP-ATPIII definition had increased mortality risk from CVD (RR=1.98; p=0.012), than in men with identified MS by the IDF and the new JIS definition. In women the MS was not associated with risk of mortality from CVD.
  
  
  CONCLUSIONS
  The MS definitions according to the IDF and JIS criteria appear to be a slightly better predictor of all-cause mortality and mortality from CVD; MS according to the NCEP-ATPIII criteria appears to be a better predictor of mortality from CVD in men.
authors.affiliation: Laboratory of Population Studies, Institute of Cardiology of Medical Academy, Lithuanian University of Health Sciences, Lithuania. Electronic address: dalia.luksiene@lsmuni.lt.
authors.forename: Dalia
authors.initials: D
authors.lastname: Luksiene
authors.affiliation: Laboratory of Population Studies, Institute of Cardiology of Medical Academy, Lithuanian University of Health Sciences, Lithuania; Laboratory of Physical Activity Epidemiology of Lithuanian Academy of Physical Education, Lithuania.
authors.forename: Migle
authors.initials: M
authors.lastname: Baceviciene
authors.affiliation: Laboratory of Population Studies, Institute of Cardiology of Medical Academy, Lithuanian University of Health Sciences, Lithuania.
authors.forename: Kristina
authors.initials: K
authors.lastname: Jureniene
authors.affiliation: Laboratory of Population Studies, Institute of Cardiology of Medical Academy, Lithuanian University of Health Sciences, Lithuania.
authors.forename: Gailute
authors.initials: G
authors.lastname: Bernotiene
authors.affiliation: Laboratory of Population Studies, Institute of Cardiology of Medical Academy, Lithuanian University of Health Sciences, Lithuania.
authors.forename: Regina
authors.initials: R
authors.lastname: Reklaitiene
authors.affiliation: Laboratory of Population Studies, Institute of Cardiology of Medical Academy, Lithuanian University of Health Sciences, Lithuania.
authors.forename: Ricardas
authors.initials: R
authors.lastname: Radisauskas
authors.affiliation: Laboratory of Population Studies, Institute of Cardiology of Medical Academy, Lithuanian University of Health Sciences, Lithuania.
authors.forename: Abdonas
authors.initials: A
authors.lastname: Tamosiunas
mesh_terms: D000328:Adult; D002318:Cardiovascular Diseases / Q000209:etiology / Q000401:mortality*; D002423:Cause of Death; D005260:Female; D006801:Humans; D008097:Lithuania / Q000453:epidemiology; D008297:Male; D024821:Metabolic Syndrome / Q000401:mortality*; D008875:Middle Aged; D015233:Models, Statistical; D018570:Risk Assessment; D016019:Survival Analysis; D014505:Urban Population