title: Radial multigradient-echo DCE-MRI for 3D K(trans) mapping with individual arterial input function measurement in mouse tumor models.
abstract: The purpose of this study was to provide proof of concept for a new three-dimensional (3D) radial dynamic contrast enhanced MRI acquisition technique, called "Radial Entire Tumor with Individual Arterial input function dynamic contrast-enhanced MRI" (RETIA dynamic contrast-enhanced MRI), which allows for the simultaneous measurement of an arterial input function in the mouse heart at 2 s temporal resolution and coverage of the whole tumor. Alternating 2D and 3D projections contribute to the 2D heart image or 3D tumor data with a 3-cm field of view. Sixty-four 2D images of the heart are obtained during acquisition of each 3D tumor dataset. In a pilot study, global K(trans) and ve values were measured in four mice, in a respiratory motion-animated subcutaneously implanted breast tumor model. This technique is expected to be most useful for the characterization of microvasculature in motion-animated orthotopic tumors.
authors.affiliation: Institut Curie, Research Center, Orsay, France; Institut national de la santé et de la recherche médicale (INSERM), U759, Orsay, France; Université Paris Sud, Orsay, France.
authors.forename: Julien
authors.initials: J
authors.lastname: Vautier
authors.forename: Nadine
authors.initials: N
authors.lastname: El Tannir El Tayara
authors.forename: Christine
authors.initials: C
authors.lastname: Walczak
authors.forename: Joël
authors.initials: J
authors.lastname: Mispelter
authors.forename: Andreas
authors.initials: A
authors.lastname: Volk
mesh_terms: D000818:Animals; D001158:Arteries; D005260:Female; D006338:Heart Neoplasms / Q000098:blood supply; D019028:Magnetic Resonance Imaging, Cine / Q000379:methods*; D008325:Mammary Neoplasms, Experimental / Q000098:blood supply; D051379:Mice; D009374:Neoplasms, Experimental / Q000098:blood supply*; D010865:Pilot Projects