title: A national case-control study identifies human socio-economic status and activities as risk factors for tick-borne encephalitis in Poland.
abstract: BACKGROUND
  Tick-borne encephalitis (TBE) is endemic to Europe and medically highly significant. This study, focused on Poland, investigated individual risk factors for TBE symptomatic infection.
  
  
  RESULTS
  In a nation-wide population-based case-control study, of the 351 TBE cases reported to local health departments in Poland in 2009, 178 were included in the analysis. For controls, of 2704 subjects (matched to cases by age, sex, district of residence) selected at random from the national population register, two were interviewed for each case and a total of 327 were suitable for the analysis. Questionnaires yielded information on potential exposure to ticks during the six weeks (maximum incubation period) preceding disease onset in each case. Independent associations between disease and socio-economic factors and occupational or recreational exposure were assessed by conditional logistic regression, stratified according to residence in known endemic and non-endemic areas. Adjusted population attributable fractions (PAF) were computed for significant variables. In endemic areas, highest TBE risk was associated with spending ≥10 hours/week in mixed forests and harvesting forest foods (adjusted odds ratio 19.19 [95% CI: 1.72-214.32]; PAF 0.127 [0.064-0.193]), being unemployed (11.51 [2.84-46.59]; 0.109 [0.046-0.174]), or employed as a forester (8.96 [1.58-50.77]; 0.053 [0.011-0.100]) or non-specialized worker (5.39 [2.21-13.16]; 0.202 [0.090-0.282]). Other activities (swimming, camping and travel to non-endemic regions) reduced risk. Outside TBE endemic areas, risk was greater for those who spent ≥10 hours/week on recreation in mixed forests (7.18 [1.90-27.08]; 0.191 [0.065-0.304]) and visited known TBE endemic areas (4.65 [0.59-36.50]; 0.058 [-0.007-0.144]), while travel to other non-endemic areas reduced risk.
  
  
  CONCLUSIONS
  These socio-economic factors and associated human activities identified as risk factors for symptomatic TBE in Poland are consistent with results from previous correlational studies across eastern Europe, and allow public health interventions to be targeted at particularly vulnerable sections of the population.
authors.affiliation: Department of Epidemiology, National Institute of Public Health - National Institute of Hygiene, Warsaw, Poland.
authors.forename: Pawel
authors.initials: P
authors.lastname: Stefanoff
authors.forename: Magdalena
authors.initials: M
authors.lastname: Rosinska
authors.forename: Steven
authors.initials: S
authors.lastname: Samuels
authors.forename: Dennis J
authors.initials: DJ
authors.lastname: White
authors.forename: Dale L
authors.initials: DL
authors.lastname: Morse
authors.forename: Sarah E
authors.initials: SE
authors.lastname: Randolph
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D016022:Case-Control Studies; D004675:Encephalitis, Tick-Borne / Q000453:epidemiology*; D005260:Female; D006802:Human Activities; D006801:Humans; D008297:Male; D008875:Middle Aged; D011044:Poland / Q000453:epidemiology; D012307:Risk Factors; D012923:Social Class; D011795:Surveys and Questionnaires; D055815:Young Adult