title: Metastatic atypical fibroxanthoma.
abstract: Atypical fibroxanthoma (AFX) is an undifferentiated pleomorphic sarcoma that typically has low-grade malignant potential. Although recurrences do occur, only approximately 25 cases of metastasizing AFX have been reported. Herein a patient with an AFX that metastasized and eventuated in death is described. Although AFX remains a diagnosis of exclusion, through this pedagogic case, the clinical, immunohistochemical, and genetic features that can assist in diagnosis are discussed.
authors.affiliation: Naval Medical Center, San Diego, California, USA.
authors.forename: Elizabeth K
authors.initials: EK
authors.lastname: Satter
mesh_terms: D015703:Antigens, CD / Q000032:analysis; D015214:Antigens, Differentiation, Myelomonocytic / Q000032:analysis; D001706:Biopsy; D005145:Face; D017809:Fatal Outcome; D006801:Humans; D008175:Lung Neoplasms / Q000175:diagnosis* / Q000556:secondary / Q000601:surgery; D008297:Male; D008875:Middle Aged; D008938:Mitosis; D015580:Mohs Surgery; D015260:Neprilysin / Q000032:analysis; D012509:Sarcoma / Q000175:diagnosis* / Q000556:secondary / Q000601:surgery; D012878:Skin Neoplasms / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery; D014746:Vimentin / Q000032:analysis; D000097382:CD68 Molecule
chemical_list: D015703:Antigens, CD; D015214:Antigens, Differentiation, Myelomonocytic; D015260:Neprilysin; D014746:Vimentin; C067980:CD68 antigen, human; D000097382:CD68 Molecule