title: Does bedding affect the airway and allergy?
abstract: Various cross-sectional and longitudinal studies have suggested that synthetic bedding is associated with asthma, allergic rhinitis and eczema while feather bedding seems to be protective. Synthetic bedding items have higher house dust mite allergen levels than feather bedding items. This is possibly the mechanism involved although fungal and bacterial proinflammatory compounds and volatile organic compounds may play a role. In this review we present and discuss the epidemiological evidence and suggest possible mechanisms. Primary intervention studies are required to show whether feather bedding is protective for the development of childhood asthma and allergic diseases while secondary intervention studies are required to potentially reduce symptoms and medication use in subjects with established disease.
authors.affiliation: Wellington Asthma Research Group, Department of Medicine, School of Medicine and Health Sciences, University of Otago, Wellington, New Zealand. rob.siebers@otago.ac.nz
authors.forename: R W
authors.initials: RW
authors.lastname: Siebers
authors.forename: J
authors.initials: J
authors.lastname: Crane
mesh_terms: D000818:Animals; D001249:Asthma / Q000209:etiology; D001512:Bedding and Linens / Q000009:adverse effects* / Q000469:parasitology; D004731:Endotoxins / Q000032:analysis; D004867:Equipment Design; D005241:Feathers; D006801:Humans; D006967:Hypersensitivity / Q000209:etiology*; D039981:Pyroglyphidae
chemical_list: D004731:Endotoxins