title: [Diurnal profile of arterial pressure during sleep deprivation in patients with hypertensive disease receiving antihypertensive therapy].
abstract: Diurnal profile of arterial pressure during sleep deprivation was studied by 24 hr AP monitoring in 40 patients with grade I-II AH (hypertensive disease) and slightly or moderately elevated AP. Group 1 included 10 patients who did not receive antihypertensive therapy. Group 2 (n = 30) was treated with 10 mg/d lisinopril either in the morning or in the evening. Patients of group 3 (n = 10) were given b-blocker metoprolol (35 mg at 22.00). AP monitoring was performed in duplicate (with night sleep deprivation and without it). Sleep deprivation resulted in the inverted AP profile (mean night-time AP higher than the mean daytime value) whether the patients were treated with long-acting lisinopril or with short-acting metoprolol given immediately before sleep deprivation. Mean daily AP in case of night deprivation was higher than under normal conditions.
authors.forename: A Z
authors.initials: AZ
authors.lastname: Tsfasman
authors.forename: D V
authors.initials: DV
authors.lastname: Alpaev
authors.forename: T D
authors.initials: TD
authors.lastname: Karetskaia
mesh_terms: D000328:Adult; D000959:Antihypertensive Agents / Q000008:administration & dosage* / Q000494:pharmacology; D001794:Blood Pressure / Q000187:drug effects / Q000502:physiology*; D018660:Blood Pressure Monitoring, Ambulatory; D002940:Circadian Rhythm / Q000187:drug effects / Q000502:physiology*; D006801:Humans; D006973:Hypertension / Q000188:drug therapy / Q000503:physiopathology*; D017706:Lisinopril / Q000008:administration & dosage* / Q000494:pharmacology; D008790:Metoprolol / Q000008:administration & dosage* / Q000494:pharmacology; D012720:Severity of Illness Index; D012892:Sleep Deprivation / Q000503:physiopathology*
chemical_list: D000959:Antihypertensive Agents; D017706:Lisinopril; D008790:Metoprolol