title: Free radical scavenging and immunomodulatory activities of Ganoderma lucidum polysaccharides derivatives.
abstract: Polysaccharides extracted from the fruit body of Ganoderma lucidum were sulfated and carboxymethylated as reported. Free radical scavenging and immunomodulatory effects of sulfated and carboxymethylated polysaccharides were studied. Generally, sulfated polysaccharides showed better bioactivities than that of carboxymethylated polysaccharides. The two derivatives were injected intraperitoneally with or without 5-fluorouracil over a period of 7 days in BALB/c female mice. The polysaccharide derivatives increased mouse thymus and spleen index, an indication of improved immunity in mice. At the same time, they improved superoxide dismutase and glutathione peroxidase contents in the mice body.
authors.affiliation: College of Food Science and Engineering, Northwest Agriculture and Forestry University, Yangling, Shanxi 712100, China. wjg5118@yahoo.com.cn
authors.forename: Jianguo
authors.initials: J
authors.lastname: Wang
authors.forename: Yutang
authors.initials: Y
authors.lastname: Wang
authors.forename: Xuebo
authors.initials: X
authors.lastname: Liu
authors.forename: Yahong
authors.initials: Y
authors.lastname: Yuan
authors.forename: Tianli
authors.initials: T
authors.lastname: Yue
mesh_terms: D000818:Animals; D005260:Female; D016166:Free Radical Scavengers / Q000737:chemistry* / Q000494:pharmacology*; D005609:Free Radicals / Q000737:chemistry; D056747:Immunomodulation / Q000187:drug effects*; D008745:Methylation; D051379:Mice; D008807:Mice, Inbred BALB C; D011134:Polysaccharides / Q000737:chemistry* / Q000494:pharmacology*; D020940:Reishi / Q000737:chemistry*; D013154:Spleen / Q000187:drug effects / Q000276:immunology / Q000378:metabolism; D013431:Sulfates / Q000737:chemistry; D013950:Thymus Gland / Q000187:drug effects / Q000276:immunology / Q000378:metabolism
chemical_list: D016166:Free Radical Scavengers; D005609:Free Radicals; D011134:Polysaccharides; D013431:Sulfates