title: Comparison of analytical performance of two single-step measurement devices of B-type natriuretic Peptide.
abstract: Rapid measurement of B-type natriuretic peptide (BNP) plays a practical role in the diagnosis of congestive heart failure. Analytical evaluation of a new small-footprint immunochromatography reader of BNP (Rapidpia®) was performed and compared with the commercially available SHIONOSPOT® Reader as the index. The new BNP assay had a within-run coefficient of variation (CV) of 9.0% and a between-run CV of 2.1%. Correlations between whole blood and plasma samples and those with the index SHIONOSPOT® Reader were y = 0.93x + 0.88, R2 = 0.98 and y = 1.08x - 6.67, R2 = 0.93, respectively. Based on our findings, the two point-of care (POC) assays for BNP, Rapidpia® and SHIONOSPOT® Reader, showed comparable results.
authors.affiliation: Department of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
authors.forename: Junichi
authors.initials: J
authors.lastname: Ishida
authors.forename: Toru
authors.initials: T
authors.lastname: Suzuki
authors.forename: Kenichi
authors.initials: K
authors.lastname: Aizawa
authors.forename: Daigo
authors.initials: D
authors.lastname: Sawaki
authors.forename: Ryozo
authors.initials: R
authors.lastname: Nagai
mesh_terms: D015415:Biomarkers / Q000097:blood; D002845:Chromatography / Q000295:instrumentation*; D006333:Heart Failure / Q000097:blood* / Q000175:diagnosis; D006801:Humans; D020097:Natriuretic Peptide, Brain / Q000097:blood*; D019095:Point-of-Care Systems; D015203:Reproducibility of Results
chemical_list: D015415:Biomarkers; D020097:Natriuretic Peptide, Brain