title: IGF2BP2 alternative variants associated with glutamic acid decarboxylase antibodies negative diabetes in Malaysian subjects.
abstract: BACKGROUND
  The association of Insulin-like growth factor 2 mRNA-binding protein 2 (IGF2BP2) common variants (rs4402960 and rs1470579) with type 2 diabetes (T2D) has been performed in different populations. The aim of this study was to evaluate the association of alternative variants of IGF2BP2; rs6777038, rs16860234 and rs7651090 with glutamic acid decarboxylase antibodies (GADA) negative diabetes in Malaysian Subjects.
  
  
  RESULTS
  IGF2BP2; rs6777038, rs16860234 and rs7651090 single nucleotide polymorphisms (SNPs) were genotyped in 1107 GADA negative diabetic patients and 620 control subjects of Asian from Malaysia. The additive genetic model adjusted for age, race, gender and BMI showed that alternative variants; rs6777038, rs16860234 and rs7651090 of IGF2BP2 associated with GADA negative diabetes (OR = 1.21; 1.36; 1.35, P = 0.03; 0.0004; 0.0002, respectively). In addition, the CCG haplotype and diplotype CCG-TCG increased the risk of diabetes (OR = 1.51, P = 0.01; OR = 2.36, P = 0.009, respectively).
  
  
  CONCLUSIONS
  IGF2BP2 alternative variants were associated with GADA negative diabetes. The IGF2BP2 haplotypes and diplotypes increased the risk of diabetes in Malaysian subject.
authors.affiliation: Department of Molecular Medicine, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia. sameersalem@yahoo.com
authors.forename: Sameer D
authors.initials: SD
authors.lastname: Salem
authors.forename: Riyadh
authors.initials: R
authors.lastname: Saif-Ali
authors.forename: Ikram S
authors.initials: IS
authors.lastname: Ismail
authors.forename: Zaid
authors.initials: Z
authors.lastname: Al-Hamodi
authors.forename: Rozaida
authors.initials: R
authors.lastname: Poh
authors.forename: Sekaran
authors.initials: S
authors.lastname: Muniandy
mesh_terms: D000328:Adult; D000368:Aged; D000483:Alleles; D044466:Asian People / Q000235:genetics*; D001323:Autoantibodies / Q000276:immunology; D003924:Diabetes Mellitus, Type 2 / Q000235:genetics* / Q000276:immunology; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D005968:Glutamate Decarboxylase / Q000276:immunology; D006801:Humans; D015810:Linkage Disequilibrium; D008296:Malaysia; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D016601:RNA-Binding Proteins / Q000235:genetics*
chemical_list: D001323:Autoantibodies; C498779:IGF2BP2 protein, human; D016601:RNA-Binding Proteins; D005968:Glutamate Decarboxylase