title: Re-sequencing of a virulent strain of Campylobacter jejuni NCTC11168 reveals potential virulence factors.
abstract: In vitro passage of Campylobacter jejuni strains results in phenotypic changes and a general loss of virulence, as is the case with the genome-sequenced strain C. jejuni NCTC11168. Re-sequencing of a virulent strain of NCTC11168 identified 41 SNPs or indels involving 20 genes, four intergenic regions and three pseudogenes. The genes include six motility genes, two chemotaxis genes, three hypothetical genes and a capsule biosynthesis gene, which might have a critical role in C. jejuni virulence. Additionally, we found an insertion in both Cj0676 and Cj1470c, pseudogenes in avirulent NCTC11168, but functional proteins in virulent NCTC11168.
authors.affiliation: Department of Veterinary Science and Microbiology, University of Arizona, Tucson, AZ 85721, USA. kerry.cooper@ars.usda.gov
authors.forename: Kerry K
authors.initials: KK
authors.lastname: Cooper
authors.forename: Margarethe A
authors.initials: MA
authors.lastname: Cooper
authors.forename: Andrea
authors.initials: A
authors.lastname: Zuccolo
authors.forename: Lynn A
authors.initials: LA
authors.lastname: Joens
mesh_terms: D000818:Animals; D002169:Campylobacter Infections / Q000382:microbiology; D016123:Campylobacter jejuni / Q000235:genetics* / Q000472:pathogenicity*; D005798:Genes, Bacterial; D020641:Polymorphism, Single Nucleotide; D013552:Swine; D014774:Virulence; D037521:Virulence Factors / Q000235:genetics*
chemical_list: D037521:Virulence Factors