title: Mitochondrial dysfunction in aging and longevity: a causal or protective role?
abstract: CONCLUSIONS
  Among the most highly investigated theories of aging is the mitochondrial theory of aging. The basis of this theory includes a central role for altered or compromised mitochondrial function in the pathophysiologic declines associated with aging. In general, studies in various organisms, including nematodes, rodents, and humans, have largely upheld that aging is associated with mitochondrial dysfunction. However, results from a number of studies directly testing the mitochondrial theory of aging by modulating oxidant production or scavenging in vivo in rodents have generally been inconsistent with predictions of the theory.
  
  
  BACKGROUND
  Interestingly, electron transport chain mutations or deletions in invertebrates and mice that causes mitochondrial dysfunction paradoxically leads to enhanced longevity, further challenging the mitochondrial theory of aging.
  
  
  RESULTS
  How can mitochondrial dysfunction contribute to lifespan extension in the mitochondrial mutants, and what does it mean for the mitochondrial theory of aging?
  
  
  CONCLUSIONS
  It will be important to determine the potential mechanisms that lead to enhanced longevity in the mammalian mitochondrial mutants.
authors.affiliation: 1 Barshop Institute for Longevity and Aging Studies, University of Texas Health Science Center at San Antonio , San Antonio, Texas.
authors.forename: Daniel A
authors.initials: DA
authors.lastname: Pulliam
authors.forename: Arunabh
authors.initials: A
authors.lastname: Bhattacharya
authors.forename: Holly
authors.initials: H
authors.lastname: Van Remmen
mesh_terms: D000375:Aging / Q000378:metabolism*; D000818:Animals; D059165:Hormesis; D006801:Humans; D008136:Longevity; D053078:Membrane Potential, Mitochondrial; D008928:Mitochondria / Q000502:physiology*; D024101:Mitochondrial Proteins / Q000502:physiology; D009154:Mutation; D018384:Oxidative Stress
chemical_list: D024101:Mitochondrial Proteins