title: Transgenic animals in toxicology.
abstract: Transgenic animals are a powerful tool in the exploration of the interaction of specific genes with the environment and/or toxins to understand the relation between biochemical and metabolic pathways and toxic effect. This overview discusses DNA construct design, methods for production of transgenic animals, including pronuclear fusion, gene targeting and chimera production, animal husbandry, and colony management.
authors.affiliation: University of Washington, Seattle, Washington, USA.
authors.forename: W C
authors.initials: WC
authors.lastname: Ladiges
authors.forename: C B
authors.initials: CB
authors.lastname: Ware
mesh_terms: D000822:Animal Husbandry; D000818:Animals; D005786:Gene Expression Regulation / Q000187:drug effects; D005821:Genetic Techniques; D006801:Humans; D051379:Mice; D008822:Mice, Transgenic; D023421:Models, Animal; D018570:Risk Assessment; D018675:Toxicity Tests / Q000379:methods*; D014116:Toxicology / Q000379:methods*