title: [Microcirculatory investigations in hemophilia patients].
abstract: OBJECTIVE
  to evaluate microcirculation (MC) and its influencing factors in hemophilia patients.
  
  
  METHODS
  In 44 hemophilia patients with recurrent hemarthrosis, laser Doppler flowmetry was used to evaluate resting MC above the index fingers, knee and ankle joints during an occlusion test, with allowance made for muscle and adipose tissue mass.
  
  
  RESULTS
  The increased perfusion value above the afflicted joints was found to correspond to the phase of an exacerbation of posthemorrhagic inflammation and to be a risk factor of recurrent hemarrthrosis. Analysis of the occlusion test above the knee joints and index fingers revealed a diminished MC reserve and a tendency to precapillary spasm. MC changes were more pronounced in a shortage of muscle and adipose tissue mass.
  
  
  CONCLUSIONS
  Hemophilia patients must regularly do physical exercises to make skeletal muscles develop well in order to prevent an exacerbation of the joint inflammatory process.
authors.forename: I L
authors.initials: IL
authors.lastname: Davydkin
authors.forename: Iu A
authors.initials: IuA
authors.lastname: Kosiakova
mesh_terms: D000273:Adipose Tissue / Q000378:metabolism; D000293:Adolescent; D000328:Adult; D000843:Ankle Joint / Q000098:blood supply; D005081:Exercise Therapy / Q000379:methods; D005384:Finger Joint / Q000098:blood supply; D006395:Hemarthrosis / Q000209:etiology / Q000473:pathology*; D006467:Hemophilia A / Q000503:physiopathology*; D006801:Humans; D007719:Knee Joint / Q000098:blood supply; D017078:Laser-Doppler Flowmetry; D008833:Microcirculation; D018482:Muscle, Skeletal / Q000378:metabolism; D012008:Recurrence; D012307:Risk Factors; D055815:Young Adult