title: The combined effect of persistent organic pollutants in the serum POP mixture in Greenlandic Inuit: xenoestrogenic, xenoandrogenic and dioxin-like transactivities.
abstract: Greenlandic Inuit have high body burden of persistent organic pollutants (POPs). We analyzed the combined effect of the actual lipophilic serum POP mixture on estrogen-, androgen- and aryl hydrocarbon-receptor functions as effect biomarkers, and the associations between the effect biomarkers and serum POPs, and lifestyle characteristics. The serum POPs were extracted from 232 Inuit from Ittoqqortoormiit, Narsaq and Qeqertarsuaq. The POP-related receptor transactivities correlated negatively to the POP levels and were associated to the lifestyle characteristics. The POP-related receptor transactivities can be used as effect biomarkers. The serum POPs have hormone disruptive potentials.
authors.affiliation: Department of Public Health, Centre for Arctic Health & Cellular and Molecular Toxicology, Aarhus University, Aarhus C, Denmark.
authors.forename: Tanja
authors.initials: T
authors.lastname: Krüger
authors.forename: Manhai
authors.initials: M
authors.lastname: Long
authors.forename: Mandana
authors.initials: M
authors.lastname: Ghisari
authors.forename: Eva C
authors.initials: EC
authors.lastname: Bonefeld-Jørgensen
mesh_terms: D000293:Adolescent; D000328:Adult; D000704:Analysis of Variance; D015415:Biomarkers / Q000097:blood; D004147:Dioxins / Q000097:blood; D004785:Environmental Pollutants / Q000097:blood*; D005260:Female; D005843:Geography; D006116:Greenland; D006801:Humans; D004930:Inuit; D008019:Life Style; D008297:Male; D008875:Middle Aged; D009930:Organic Chemicals / Q000097:blood; D011078:Polychlorinated Biphenyls / Q000097:blood; D011944:Receptors, Androgen / Q000097:blood*; D018336:Receptors, Aryl Hydrocarbon / Q000097:blood*; D011960:Receptors, Estrogen / Q000097:blood*; D015262:Xenobiotics / Q000097:blood; D055815:Young Adult
chemical_list: D015415:Biomarkers; D004147:Dioxins; D004785:Environmental Pollutants; D009930:Organic Chemicals; D011944:Receptors, Androgen; D018336:Receptors, Aryl Hydrocarbon; D011960:Receptors, Estrogen; D015262:Xenobiotics; D011078:Polychlorinated Biphenyls