title: [The roles of intestinal and renal sodium dependent phosphate transporters in phosphate homeostasis].
abstract: Inorganic phosphate (Pi) is an essential nutrient for several biological functions, including intracellular signal transduction, the production and function of cell membranes, and energy exchange. To achieve these functions, a transport system is required to transfer Pi across hydrophobic cell membranes. Pi (re) absorption in the small intestine and renal proximal tubules is important for Pi homeostasis. Three types of NaPi transporters (types I - III ) have been identified : solute carrier series SLC17A1 (NPT1/NaPi- I /OATv1) , SLC34 (NaPi- II a, NaPi- II b, NaPi- II c) , and SLC20 (PiT1, PiT2) , respectively. In this review, we discuss the role of NaPi transporters in Pi homeostasis.
authors.affiliation: Department of Molecular Nutrition, Institution of Health Biosciences, The University of Tokushima Graduate School, Japan.
authors.forename: Hiroko
authors.initials: H
authors.lastname: Segawa
authors.forename: Shohei
authors.initials: S
authors.lastname: Sasaki
authors.forename: Tomo
authors.initials: T
authors.lastname: Mukai
authors.forename: Mai
authors.initials: M
authors.lastname: Manabe
authors.forename: Shinsuke
authors.initials: S
authors.lastname: Kido
authors.forename: Sawako
authors.initials: S
authors.lastname: Tatsumi
authors.forename: Kenichi
authors.initials: K
authors.lastname: Miyamoto
mesh_terms: D000818:Animals; D006706:Homeostasis; D006801:Humans; D007413:Intestinal Mucosa / Q000378:metabolism*; D007668:Kidney / Q000378:metabolism*; D010710:Phosphates / Q000378:metabolism*; D012964:Sodium / Q000378:metabolism*; D050608:Sodium-Phosphate Cotransporter Proteins / Q000378:metabolism*
chemical_list: D010710:Phosphates; D050608:Sodium-Phosphate Cotransporter Proteins; D012964:Sodium