title: WU and KI polyomaviruses in respiratory samples from allogeneic hematopoietic cell transplant recipients.
abstract: Data are limited regarding 2 new human polyomaviruses, KI polyomavirus (KIPyV) and WU polyomavirus (WUPyV), in immunocompromised patients. We used real-time PCR to test for these and 12 respiratory viruses in 2,732 nasal wash samples collected during the first year after allogeneic hematopoietic cell transplantation from 222 patients. Specimens were collected weekly until day 100; then at least every 3 months. One year after hematopoietic cell transplantation, the cumulative incidence estimate was 26% for KIPyV and 8% for WUPyV. Age <20 years predicted detection of KIPyV (hazard ratio [HR] 4.6) and WUPyV (HR 4.4), and detection of a respiratory virus in the previous 2 weeks predicted KIPyV detection (HR 3.4). Sputum production and wheezing were associated with detection of KIPyV in the past week and WUPyV in the past month. There were no associations with polyomavirus detection and acute graft versus host disease, cytomegalovirus reactivation, neutropenia, lymphopenia, hospitalization, or death.
authors.affiliation: University of Washington, Seattle, Washington 98102, USA. kuypers@u.washington.edu
authors.forename: Jane
authors.initials: J
authors.lastname: Kuypers
authors.forename: Angela P
authors.initials: AP
authors.lastname: Campbell
authors.forename: Katherine A
authors.initials: KA
authors.lastname: Guthrie
authors.forename: Nancy L
authors.initials: NL
authors.lastname: Wright
authors.forename: Janet A
authors.initials: JA
authors.lastname: Englund
authors.forename: Lawrence
authors.initials: L
authors.lastname: Corey
authors.forename: Michael
authors.initials: M
authors.lastname: Boeckh
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D002675:Child, Preschool; D004279:DNA, Viral / Q000235:genetics; D005260:Female; D018380:Hematopoietic Stem Cell Transplantation / Q000009:adverse effects*; D006801:Humans; D016867:Immunocompromised Host; D015994:Incidence; D007223:Infant; D008297:Male; D008875:Middle Aged; D009305:Nasopharynx / Q000821:virology; D016133:Polymerase Chain Reaction / Q000379:methods; D011120:Polyomavirus / Q000145:classification / Q000235:genetics / Q000302:isolation & purification*; D027601:Polyomavirus Infections / Q000453:epidemiology* / Q000503:physiopathology / Q000821:virology; D012137:Respiratory System / Q000821:virology*; D013997:Time Factors; D014184:Transplantation, Homologous / Q000009:adverse effects*; D014412:Tumor Virus Infections / Q000453:epidemiology* / Q000503:physiopathology / Q000821:virology; D055815:Young Adult
chemical_list: D004279:DNA, Viral