title: Validation of the association between PSMA6 -8 C/G polymorphism and type 2 diabetes mellitus in Chinese Dongxiang and Han populations.
abstract: OBJECTIVE
  The aim of our study was to validate association between -8 C/G variant of PSMA6 gene and T2DM in Chinese Dongxiang and Han populations.
  
  
  METHODS
  We genotyped PSMA6 gene -8 C/G polymorphism in the control groups and T2DM groups in two populations from China using PCR-RFLP technique. Phenotypes and biochemical indicators were measured by biochemical technique.
  
  
  RESULTS
  The frequencies of CG+GG genotype were observably different from CC genotype in the T2DM groups and control groups (for Dongxiang population: OR = 1.341, 95% CI: 1.101-1.632, P = 0.004; for Han population: OR = 1.313, 95% CI: 1.085-1.569, P = 0.006 after adjusting for gender, age, and BMI, respectively). In the Dongxiang population, the FPG, HOMA-IR, SBP and TG levels of CG+GG genotype were markedly higher than those of the CC genotype in control group (all P < 0.05). However, in the Han population, we only found that the FPI level of the CC genotype was significantly higher than that of the CG+GG genotype in control group (P < 0.05).
  
  
  CONCLUSIONS
  Our investigation suggests that -8 C/G variant of PSMA6 gene may be associated with T2DM and diabetes-related metabolic traits in Chinese Dongxiang and Han populations.
authors.affiliation: Department of Endocrinology, People's Hospital of Gansu Province, Lanzhou City 730000, Gansu Province, China. liujingwelcome@126.com
authors.forename: Jing
authors.initials: J
authors.lastname: Liu
authors.forename: Xin-jian
authors.initials: XJ
authors.lastname: Yuan
authors.forename: Ju-xiang
authors.initials: JX
authors.lastname: Liu
authors.forename: Li-min
authors.initials: LM
authors.lastname: Tian
authors.forename: Jin-xing
authors.initials: JX
authors.lastname: Quan
authors.forename: Jia
authors.initials: J
authors.lastname: Liu
authors.forename: Xiao-hui
authors.initials: XH
authors.lastname: Chen
authors.forename: Yun-fang
authors.initials: YF
authors.lastname: Wang
authors.forename: Zhi-yong
authors.initials: ZY
authors.lastname: Shi
authors.forename: Jun-ling
authors.initials: JL
authors.lastname: Zhang
mesh_terms: D000328:Adult; D044466:Asian People; D002681:China; D003924:Diabetes Mellitus, Type 2 / Q000453:epidemiology* / Q000235:genetics*; D005260:Female; D005787:Gene Frequency / Q000235:genetics; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D046988:Proteasome Endopeptidase Complex / Q000235:genetics*
chemical_list: C465641:PSMA6 protein, human; D046988:Proteasome Endopeptidase Complex