title: NIS-catalyzed reactions: amidation of acetophenones and oxidative amination of propiophenones.
abstract: Single-step amination: the N-iodosuccinimide (NIS)-catalyzed amidation of acetophenone derivatives by using tert-butylhydroperoxide (TBHP) as an oxidant is presented. A variety of acetyl derivatives of heterocyclic compounds were easily converted to their corresponding ketoamides under these conditions. A new, NIS-catalyzed amination of propiophenone and its derivatives in the presence of TBHP to furnish the corresponding 2-aminoketone derivatives is the first reported single-step amination of propiophenone derivatives.
authors.affiliation: Department of Organic chemistry, Indian Institute of Science, Bangalore, Karnataka, India.
authors.forename: Manjunath
authors.initials: M
authors.lastname: Lamani
authors.forename: Kandikere Ramaiah
authors.initials: KR
authors.lastname: Prabhu
mesh_terms: D000098:Acetophenones / Q000138:chemical synthesis* / Q000737:chemistry*; D000586:Amination; D002384:Catalysis; D015394:Molecular Structure; D016877:Oxidants / Q000737:chemistry*; D010084:Oxidation-Reduction; D011427:Propiophenones / Q000138:chemical synthesis* / Q000737:chemistry*; D013388:Succinimides / Q000737:chemistry*
chemical_list: D000098:Acetophenones; D016877:Oxidants; D011427:Propiophenones; D013388:Succinimides; C008155:N-iodosuccinimide