title: [Combined treatment with photodynamic therapy and intravitreal dexamethasone implant (Ozurdex(®)) for circumscribed choroidal hemangioma].
abstract: OBJECTIVE
  We report a case of symptomatic circumscribed choroidal hemangioma (CCH) treated by photodynamic therapy (PDT) combined with injection of an intravitreal dexamethasone implant (IDI) (Ozurdex(®)).
  
  
  METHODS
  A 39-year-old woman was referred to our outpatient clinic for a progressive decrease in vision of her right eye, measured at 20/25, due to subretinal exudation (SRE) associated with juxtapapillary CCH. Basal diameter of the CCH was 6mm, and its height was 2mm. Treatment consisted of injection of an IDI followed 15 days later by PDT with a single spot covering the tumor (intensity of 600 mW/cm(2) for 83 seconds [50 J/cm(2)]). Six weeks after PDT, we noted improvement of the vision to 20/20, complete resolution of SRE, and tumor flattening. No side-effects were observed. Anatomic and functional results remained unchanged over 9 months of follow-up.
  
  
  CONCLUSIONS
  This case suggests that IDI (Ozurdex(®)) potentiates the effect of PDT with less risk of local side-effects than triamcinolone acetonide. Further evaluation of this protocol remains necessary. Nonetheless, combined treatment with injection of IDI followed 15 days later by PDT for the treatment of symptomatic CCH may prove to be a sound alternative to radiotherapy and may be more efficacious than PDT alone.
authors.affiliation: Service d'ophtalmologie, CHU de Brest, 2, avenue Foch, 29609 Brest, France.
authors.forename: L
authors.initials: L
authors.lastname: Bazin
authors.forename: J
authors.initials: J
authors.lastname: Gambrelle
mesh_terms: D000328:Adult; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage; D002830:Choroid Neoplasms / Q000188:drug therapy* / Q000473:pathology; D003131:Combined Modality Therapy; D003907:Dexamethasone / Q000008:administration & dosage*; D004343:Drug Implants / Q000008:administration & dosage; D005260:Female; D006391:Hemangioma / Q000188:drug therapy* / Q000473:pathology; D006801:Humans; D058449:Intravitreal Injections; D010778:Photochemotherapy; D017319:Photosensitizing Agents / Q000008:administration & dosage; D016896:Treatment Outcome
chemical_list: D000893:Anti-Inflammatory Agents; D004343:Drug Implants; D017319:Photosensitizing Agents; D003907:Dexamethasone