title: Protective effects of Sonchus asper (L.) Hill, (Asteraceae) against CCl(4-)induced oxidative stress in the thyroid tissue of rats.
abstract: BACKGROUND
  Sonchus asper (L.) Hill, (Asteraceae) is used in Pakistan as a traditional ("folk") medicine for the treatment of hormonal disorders and oxidative stress. The present study was aimed to evaluate the efficacy of Sonchus asper (L.) Hill, (Asteraceae) methanolic extract (SAME) on hormonal dysfunction in thyroid tissue after carbon tetrachloride (CCl4)-induced oxidative stress.
  
  
  METHODS
  To examine the effects of SAME against the oxidative stress of CCl4 in thyroid tissue, 30 male albino rats were used. Protective effects of SAME were observed on thyroid hormonal levels, activities of antioxidant enzymes, lipid peroxidation (TBARS) and DNA damage.
  
  
  RESULTS
  Treatment with CCl4 significantly (P<0.01) reduced the levels of T3 and T4 and increased TSH levels. CCl4 exposure in rats reduced the activities of antioxidant enzymes but increased lipid peroxidation and DNA damage. Co-administration of SAME significantly (P<0.01) improved these alterations with respect to hormonal levels, activities of antioxidant enzymes and lipid peroxidation close to those seen in control rats.
  
  
  CONCLUSIONS
  These results suggest that SAME can protect thyroid tissue against oxidative damage, possibly through the antioxidant effects of its bioactive compounds.
authors.affiliation: Department of Biotechnology, Faculty of Sciences, University of Science and Technology, Bannu, Pakistan. Rahmatgul_81@yahoo.com
authors.forename: Rahmat Ali
authors.initials: RA
authors.lastname: Khan
mesh_terms: D000818:Animals; D002251:Carbon Tetrachloride / Q000009:adverse effects; D002374:Catalase / Q000378:metabolism; D004249:DNA Damage / Q000187:drug effects; D015227:Lipid Peroxidation / Q000187:drug effects; D008297:Male; D016660:NAD(P)H Dehydrogenase (Quinone) / Q000378:metabolism; D018384:Oxidative Stress / Q000187:drug effects*; D009195:Peroxidase / Q000378:metabolism; D010936:Plant Extracts / Q000008:administration & dosage*; D020011:Protective Agents / Q000008:administration & dosage*; D051381:Rats; D031184:Sonchus / Q000737:chemistry*; D013482:Superoxide Dismutase / Q000378:metabolism; D013961:Thyroid Gland / Q000187:drug effects / Q000201:enzymology / Q000378:metabolism*; D013963:Thyroid Hormones / Q000097:blood
chemical_list: D010936:Plant Extracts; D020011:Protective Agents; D013963:Thyroid Hormones; D002251:Carbon Tetrachloride; D002374:Catalase; D009195:Peroxidase; D013482:Superoxide Dismutase; D016660:NAD(P)H Dehydrogenase (Quinone)