title: Serum levels of perfluorinated compounds and sperm Y:X chromosome ratio in two European populations and in Inuit from Greenland.
abstract: This study investigated whether perfluorooctanoic acid (PFOA) and perfluorooctanesulfonate (PFOS), which exhibit reproductive toxicity in experimental animals, affect sperm sex chromosome ratio. The Y:X ratio was determined by fluorescence in situ hybridization. Serum concentrations of PFOA and PFOS were measured in 607 men from Greenland, Poland and Ukraine using liquid chromatography-tandem mass spectrometry. Data was analyzed by linear and nonlinear regression. We observed no associations between PFOA and Y:X ratio (p=0.845 in a linear model, p=0.296 in a nonlinear model). A positive nonlinear association between PFOS and Y:X ratio was observed (p=0.016), with no association in a linear model (p=0.118). Analyzing the populations separately, a negative trend between categorized PFOS exposure and Y:X ratio was observed for the Inuit (B=-0.002, p=0.044). In conclusion, there was a negative trend between Y:X ratio and PFOS in the Inuit, while there was no association between PFOA and the Y:X ratio in adult men.
authors.affiliation: Department of Clinical Sciences, Molecular Genetic Reproductive Medicine, Lund University, Malmö, Sweden. Linus.Kvist@med.lu.se
authors.forename: Linus
authors.initials: L
authors.lastname: Kvist
authors.forename: Yvonne Lundberg
authors.initials: YL
authors.lastname: Giwercman
authors.forename: Bo A G
authors.initials: BA
authors.lastname: Jönsson
authors.forename: Christian H
authors.initials: CH
authors.lastname: Lindh
authors.forename: Jens-Peter
authors.initials: JP
authors.lastname: Bonde
authors.forename: Gunnar
authors.initials: G
authors.lastname: Toft
authors.forename: Pawel
authors.initials: P
authors.lastname: Strucinski
authors.forename: Henning S
authors.initials: HS
authors.lastname: Pedersen
authors.forename: Valentyna
authors.initials: V
authors.lastname: Zvyezday
authors.forename: Aleksander
authors.initials: A
authors.lastname: Giwercman
mesh_terms: D017738:Alkanesulfonic Acids / Q000097:blood*; D002210:Caprylates / Q000097:blood*; D041321:Chromosomes, Human, X; D041322:Chromosomes, Human, Y; D004784:Environmental Monitoring; D004785:Environmental Pollutants / Q000097:blood*; D005466:Fluorocarbons / Q000097:blood*; D006116:Greenland; D006801:Humans; D004930:Inuit / Q000235:genetics; D008297:Male; D013094:Spermatozoa; D044465:White People / Q000235:genetics
chemical_list: D017738:Alkanesulfonic Acids; D002210:Caprylates; D004785:Environmental Pollutants; D005466:Fluorocarbons; C023036:perfluorooctanoic acid; C076994:perfluorooctane sulfonic acid