title: Plasma soluble urokinase plasminogen activator receptor (suPAR) levels in systemic lupus erythematosus.
abstract: OBJECTIVE
  Soluble urokinase plasminogen activator receptor (suPAR) is a biomarker of systemic inflammation. We aimed to characterize plasma suPAR levels in SLE patients.
  
  
  METHODS
  We measured plasma suPAR, C reactive protein (CRP) and erythrocyte sedimentation rate (ESR) in 89 SLE patients and 29 healthy controls.
  
  
  RESULTS
  suPAR and ESR values were higher in SLE than in controls, while CRP levels were comparable. ROC analysis of suPAR levels indicated a cut-off value of 5.70 ng/mL to distinguish patients with high disease activity (SLEDAI >8).
  
  
  CONCLUSIONS
  suPAR might be an objective marker for identifying SLE patients with active disease.
authors.affiliation: First Department of Pediatrics, Semmelweis University, Budapest, Hungary.
authors.forename: Gergely
authors.initials: G
authors.lastname: Toldi
authors.forename: Balázs
authors.initials: B
authors.lastname: Szalay
authors.forename: Gabriella
authors.initials: G
authors.lastname: Bekő
authors.forename: Márta
authors.initials: M
authors.lastname: Bocskai
authors.forename: Magdolna
authors.initials: M
authors.lastname: Deák
authors.forename: László
authors.initials: L
authors.lastname: Kovács
authors.forename: Barna
authors.initials: B
authors.lastname: Vásárhelyi
authors.forename: Attila
authors.initials: A
authors.lastname: Balog
mesh_terms: D000328:Adult; D000368:Aged; D015415:Biomarkers / Q000097:blood*; D001799:Blood Sedimentation; D002097:C-Reactive Protein / Q000378:metabolism; D005260:Female; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000097:blood* / Q000175:diagnosis; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D012372:ROC Curve; D055293:Receptors, Urokinase Plasminogen Activator / Q000097:blood*; D012995:Solubility
chemical_list: D015415:Biomarkers; D055293:Receptors, Urokinase Plasminogen Activator; D002097:C-Reactive Protein