title: Changes of inflammatory factors after intravitreal triamcinolone acetonide for macular edema with central retinal vein occlusion.
abstract: OBJECTIVE
  To investigate the effect of intravitreal triamcinolone acetonide (TA) on aqueous humor levels of vascular endothelial growth factor (VEGF), soluble intercellular adhesion molecule 1 (sICAM-1), and pigment epithelium-derived factor (PEDF) in patients with central retinal vein occlusion (CRVO) and macular edema.
  
  
  METHODS
  We measured VEGF, sICAM-1, and PEDF levels in aqueous humor samples from 2 eyes of 2 CRVO patients during injection of TA.
  
  
  RESULTS
  In both patients, the VEGF and sICAM-1 levels in aqueous humor samples obtained during initial injection of TA were higher than at the time of reinjection. Conversely, the initial PEDF levels were lower than those at reinjection.
  
  
  CONCLUSIONS
  Aqueous humor levels of VEGF and sICAM-1 were decreased by TA treatment in 2 CRVO patients, while PEDF was increased. Intravitreal TA could be an option for CRVO patients with a low PEDF level and/or moderate VEGF and sICAM-1 levels.
authors.affiliation: Department of Ophthalmology, Yachiyo Medical Center, Tokyo Women's Medical University, Chiba, Japan. noma-hide@umin.ac.jp
authors.forename: Hidetaka
authors.initials: H
authors.lastname: Noma
authors.forename: Hideharu
authors.initials: H
authors.lastname: Funatsu
authors.forename: Tatsuya
authors.initials: T
authors.lastname: Mimura
mesh_terms: D000368:Aged; D001082:Aqueous Humor / Q000187:drug effects / Q000378:metabolism; D005136:Eye Proteins / Q000187:drug effects / Q000378:metabolism; D005260:Female; D005938:Glucocorticoids / Q000008:administration & dosage / Q000627:therapeutic use*; D006801:Humans; D007249:Inflammation / Q000188:drug therapy / Q000473:pathology; D018799:Intercellular Adhesion Molecule-1 / Q000187:drug effects / Q000378:metabolism; D058449:Intravitreal Injections; D008269:Macular Edema / Q000188:drug therapy* / Q000473:pathology; D008297:Male; D009414:Nerve Growth Factors / Q000187:drug effects / Q000378:metabolism; D012170:Retinal Vein Occlusion / Q000188:drug therapy* / Q000473:pathology; D015843:Serpins / Q000187:drug effects / Q000378:metabolism; D014222:Triamcinolone Acetonide / Q000008:administration & dosage / Q000627:therapeutic use*; D042461:Vascular Endothelial Growth Factor A / Q000187:drug effects / Q000378:metabolism; D000099174:Pigment Epithelium-Derived Factor
chemical_list: D005136:Eye Proteins; D005938:Glucocorticoids; D018799:Intercellular Adhesion Molecule-1; D009414:Nerve Growth Factors; D015843:Serpins; D014222:Triamcinolone Acetonide; D042461:Vascular Endothelial Growth Factor A; D000099174:Pigment Epithelium-Derived Factor