title: Lateral laser speckle contrast analysis combined with line beam scanning illumination to improve the sampling depth of blood flow imaging.
abstract: We present a lateral laser speckle contrast analysis method combined with line beam scanning illumination to improve the sampling depth of blood flow imaging. Both the phantom and animal experimental results suggest that localized illumination and lateral speckle contrast analysis can significantly enhance the deep blood flow signal to improve the sampling depth of laser speckle contrast imaging compared with the traditional full-field illumination laser speckle contrast analysis method.
authors.affiliation: Britton Chance Center for Biomedical Photonics, Wuhan National Laboratory for Optoelectronics, Huazhong University of Science and Technology, Wuhan, China.
authors.forename: Heng
authors.initials: H
authors.lastname: He
authors.forename: Ying
authors.initials: Y
authors.lastname: Tang
authors.forename: Fangyuan
authors.initials: F
authors.lastname: Zhou
authors.forename: Jia
authors.initials: J
authors.lastname: Wang
authors.forename: Qingming
authors.initials: Q
authors.lastname: Luo
authors.forename: Pengcheng
authors.initials: P
authors.lastname: Li
mesh_terms: D000818:Animals; D001783:Blood Flow Velocity / Q000502:physiology*; D004867:Equipment Design; D019544:Equipment Failure Analysis; D007089:Image Enhancement / Q000295:instrumentation*; D017078:Laser-Doppler Flowmetry / Q000295:instrumentation*; D008029:Lighting / Q000295:instrumentation*; D008297:Male; D051381:Rats; D017208:Rats, Wistar