title: Maternal history of hypertension and blood pressure response to potassium intake: the GenSalt Study.
abstract: The relation between parental history of hypertension and blood pressure response to potassium intake is unknown. A 7-day high-sodium followed by a 7-day high-sodium plus potassium dietary-feeding study was conducted from 2003 to 2005 among 1,871 Chinese participants. Those with a maternal history of hypertension had larger systolic blood pressure responses to potassium compared with those without: -4.31 (95% confidence interval (CI): -4.99, -3.62) mm Hg versus -3.35 (95% CI: -4.00, -2.70) mm Hg, respectively (P(difference) = 0.002). A consistent trend was observed for diastolic blood pressure responses: -1.80 (95% CI: -2.41, -1.20) mm Hg versus -1.35 (95% CI: -1.95, -0.74) mm Hg, respectively (P = 0.07). Stronger associations between early onset maternal hypertension and blood pressure responses were noted, with systolic blood pressure decreases of -4.80 (95% CI: -5.65, -3.95) mm Hg versus -3.55 (95% CI: -4.17, -2.93) mm Hg and diastolic blood pressure decreases of -2.25 (95% CI: -3.01, -1.50) mm Hg versus -1.42 (95% CI: -1.99, -0.85) mm Hg among those with early onset maternal hypertension versus those without, respectively (P = 0.001 and 0.009, respectively). Odds ratios for high potassium sensitivity were 1.36 (95% CI: 0.96, 1.92) and 1.60 (95% CI: 1.08, 2.36) for those with maternal hypertension and early onset maternal hypertension, respectively (P = 0.08 and 0.02, respectively). Potassium supplementation could help to reduce blood pressure among those with a maternal history of hypertension.
authors.affiliation: Department of Epidemiology, Tulane University, Tulane University School of Public Health and Tropical Medicine, New Orleans, Louisiana 70112, USA. tkelly@tulane.edu
authors.forename: Tanika N
authors.initials: TN
authors.lastname: Kelly
authors.forename: Dongfeng
authors.initials: D
authors.lastname: Gu
authors.forename: D C
authors.initials: DC
authors.lastname: Rao
authors.forename: Jing
authors.initials: J
authors.lastname: Chen
authors.forename: Jichun
authors.initials: J
authors.lastname: Chen
authors.forename: Jie
authors.initials: J
authors.lastname: Cao
authors.forename: Jianxin
authors.initials: J
authors.lastname: Li
authors.forename: Fonghong
authors.initials: F
authors.lastname: Lu
authors.forename: Jixiang
authors.initials: J
authors.lastname: Ma
authors.forename: Jianjun
authors.initials: J
authors.lastname: Mu
authors.forename: Paul K
authors.initials: PK
authors.lastname: Whelton
authors.forename: Jiang
authors.initials: J
authors.lastname: He
mesh_terms: D000293:Adolescent; D000328:Adult; D001794:Blood Pressure / Q000187:drug effects*; D002681:China / Q000453:epidemiology; D004039:Diet, Sodium-Restricted; D005260:Female; D006801:Humans; D006973:Hypertension / Q000453:epidemiology / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D009035:Mothers / Q000706:statistics & numerical data; D017419:Potassium, Dietary / Q000494:pharmacology*; D055815:Young Adult
chemical_list: D017419:Potassium, Dietary