title: What we should know about portal vein thrombosis in cirrhotic patients: a changing perspective.
abstract: Portal vein thrombosis (PVT) is one of the most common complications occurring during the natural course of liver cirrhosis. Even though PVT is often asymptomatic, the worsening of liver function, an unexpected episode of gastrointestinal bleeding or ascitic decompensation may be landmarks of PVT development. Beyond these clinical manifestations, it is debated whether PVT really has an impact on liver cirrhosis natural history or rather represents only one of its consequences. Probably PVT development should not only be considered as a matter of impaired blood flow or pro-coagulation tendency. On one hand, PVT seems a consequence of the worsening in portal vein outflow due to the increased hepatic resistance in cirrhotic livers. On the other hand, vascular microthrombosis secondary to necroinflammation may cause liver ischemia and infarction, with loss of hepatic tissue (parenchymal extinction) which is replaced by fibrotic tissue. Therefore, PVT might also be considered as the overt manifestation of the liver fibrosing process evolution and anticoagulant therapy may thus have microscopic indirect effects also on the progression of liver disease. At present, a connection between PVT development and the progression of liver fibrosis/cirrhosis has not yet been demonstrated. Nevertheless, it is not clear if PVT development may worsen cirrhotic patients' outcome by itself. Some authors tried to assess liver transplant benefit in PVT cirrhotic patients but data are contrasting. In this review, we will try to answer these questions, providing a critical analysis of data reported in literature.
authors.affiliation: Internal Medicine and Gastroenterology, Policlinico A. Gemelli, Catholic University of Rome, largo A. Gemelli, 800168 Rome, Italy. francesca.ponziani@yahoo.it
authors.forename: Francesca Romana
authors.initials: FR
authors.lastname: Ponziani
authors.forename: Maria Assunta
authors.initials: MA
authors.lastname: Zocco
authors.forename: Matteo
authors.initials: M
authors.lastname: Garcovich
authors.forename: Francesca
authors.initials: F
authors.lastname: D'Aversa
authors.forename: Davide
authors.initials: D
authors.lastname: Roccarina
authors.forename: Antonio
authors.initials: A
authors.lastname: Gasbarrini
mesh_terms: D018450:Disease Progression; D006801:Humans; D008103:Liver Cirrhosis / Q000150:complications*; D011169:Portal Vein; D020246:Venous Thrombosis / Q000453:epidemiology / Q000209:etiology* / Q000401:mortality