title: Early changes in foveal thickness in eyes with central serous chorioretinopathy.
abstract: OBJECTIVE
  To investigate when and how fast the foveal thinning occurs in central serous chorioretinopathy.
  
  
  METHODS
  Outer nuclear layer (ONL) thickness was measured in 60 eyes of 60 patients with active central serous chorioretinopathy. Patients were divided into 3 groups based on the duration of symptoms; within 1 month (Group A, 25 eyes), 1 to 6 months (Group B, 17 eyes), and >6 months (Group C, 18 eyes). Outer nuclear layer thickness and visual acuity were compared between each group. Some of the patients underwent several examinations and serial changes were analyzed.
  
  
  RESULTS
  The ONL thickness was correlated with the duration of symptoms (R = -0.61, P < 0.001). Visual acuity was worse in Group C compared with Group A (P = 0.003). The mean ONL thickness of each group and healthy contralateral eyes was 82.4, 70.2, 53.5, and 89.3 μm, respectively. Comparisons between each group showed statistical significances. Seventeen eyes in Group A were re-examined between 3 and 6 months after the first visit. The mean ONL thickness significantly decreased from 81.9 μm to 75.0 μm (P = 0.020).
  
  
  CONCLUSIONS
  In central serous chorioretinopathy, ONL thinning starts in the early stage and may continue as long as the subretinal fluid persists.
authors.affiliation: Department of Ophthalmology, Kobe City Medical Center General Hospital, Kobe, Japan.
authors.forename: Masayuki
authors.initials: M
authors.lastname: Hata
authors.forename: Akio
authors.initials: A
authors.lastname: Oishi
authors.forename: Masataka
authors.initials: M
authors.lastname: Shimozono
authors.forename: Michiko
authors.initials: M
authors.lastname: Mandai
authors.forename: Akihiro
authors.initials: A
authors.lastname: Nishida
authors.forename: Yasuo
authors.initials: Y
authors.lastname: Kurimoto
mesh_terms: D000328:Adult; D000368:Aged; D056833:Central Serous Chorioretinopathy / Q000175:diagnosis / Q000503:physiopathology*; D004396:Coloring Agents; D005260:Female; D005451:Fluorescein Angiography; D005584:Fovea Centralis / Q000473:pathology*; D006801:Humans; D007208:Indocyanine Green; D008297:Male; D008875:Middle Aged; D012163:Retinal Detachment / Q000175:diagnosis / Q000503:physiopathology*; D012189:Retrospective Studies; D058471:Subretinal Fluid; D013997:Time Factors; D041623:Tomography, Optical Coherence; D014792:Visual Acuity / Q000502:physiology
chemical_list: D004396:Coloring Agents; D007208:Indocyanine Green