title: Parallel solid-phase synthesis of diaryltriazoles.
abstract: A series of substituted diaryltriazoles was prepared by a solid-phase-synthesis protocol using a modified Wang resin. The copper(I)- or ruthenium(II)-catalyzed 1,3-cycloaddition on the polymer bead allowed a rapid synthesis of the target compounds in a parallel fashion with in many cases good to excellent yields. Substituted diaryltriazoles resemble a molecular structure similar to established terphenyl-alpha-helix peptide mimics and have therefore the potential to act as selective inhibitors for protein-protein interactions.
authors.affiliation: Fakultät für Chemie und Pharmazie, Universität Regensburg, D-93040 Regensburg, Germany.
authors.forename: Matthias
authors.initials: M
authors.lastname: Wrobel
authors.forename: Jeffrey
authors.initials: J
authors.lastname: Aubé
authors.forename: Burkhard
authors.initials: B
authors.lastname: König