title: Sustained response to weekly vinblastine in 2 children with pilomyxoid astrocytoma associated with diencephalic syndrome.
abstract: Diencephalic syndrome (DS) related to hypothalamic/chiasmatic region tumor has mainly been reported with low-grade glioma. We described 2 young children with DS related to pilomyxoid astrocytoma. Despite the recognized more agressive clinical behavior of this histologic subtype, we report successful resolution of DS and sustained tumor response with prolonged use of single-agent vinblastine.
authors.affiliation: Department of Pediatric Hematology Oncology and Bone Marrow Transplantation, Alberta Children's Hospital, ON, Canada.
authors.forename: Gurpreet
authors.initials: G
authors.lastname: Singh
authors.forename: Xing Chang
authors.initials: XC
authors.lastname: Wei
authors.forename: Walter
authors.initials: W
authors.lastname: Hader
authors.forename: Jennifer A
authors.initials: JA
authors.lastname: Chan
authors.forename: Eric
authors.initials: E
authors.lastname: Bouffet
authors.forename: Lucie
authors.initials: L
authors.lastname: Lafay-Cousin
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000627:therapeutic use*; D001254:Astrocytoma / Q000150:complications / Q000188:drug therapy*; D005260:Female; D006801:Humans; D007027:Hypothalamic Diseases / Q000188:drug therapy*; D007029:Hypothalamic Neoplasms / Q000150:complications / Q000188:drug therapy*; D007223:Infant; D008297:Male; D014747:Vinblastine / Q000627:therapeutic use*
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D014747:Vinblastine