title: A 15-year-old female with amenorrhea, abdominal distention, and elevated human chorionic gonadotropin: pregnancy, right? Not so fast….
abstract: Nongestational choriocarcinoma, a rare ovarian tumor, may present in young women with amenorrhea, abdominal distention, and elevated urine human chorionic gonadotropin (hCG), all of which may be mistaken for pregnancy. A 15-year-old Hispanic female, who reported no sexual activity, presented with 6 months of amenorrhea, abdominal pain, and progressive abdominal distension. Initially, suspicion of pregnancy was considered. Physical examination was significant for abdominal distension, but no uterine fundus or fetal anatomy could be palpated, and auscultation did not reveal any fetal heart sounds or bruits. Laboratory values showed elevated urine hCG, cancer antigen 125, and cancer antigen 19.9 levels but normal serum hCG level and was inconsistent with pregnancy. Computed tomographic scans revealed a large abdominal heterogeneous mass and pleural effusions. Salpingo-oophorectomy with total omentectomy and inversion appendectomy removed a 21 × 20.5 × 16.5-cm tumor. Pathological testing determined it to be a nongestational choriocarcinoma. This rare tumor is more common in the pediatric adolescent population than in adults. Surgical resection and chemotherapy often result in a positive prognosis. In female adolescent patients presenting with elevated hCG level, amenorrhea, and abdominal distention, choriocarcinoma should be considered, especially in those with no history of sexual activity or before menarche.
authors.affiliation: Department of Pediatrics, Westchester Medical Center, Valhalla, NY, USA.
authors.forename: Arun
authors.initials: A
authors.lastname: Aggarwal
authors.forename: Anthony J
authors.initials: AJ
authors.lastname: Ocon
authors.forename: Kumara
authors.initials: K
authors.lastname: Nibhanipudi
mesh_terms: D000293:Adolescent; D000568:Amenorrhea / Q000097:blood / Q000175:diagnosis / Q000209:etiology*; D014408:Biomarkers, Tumor / Q000097:blood; D031954:Choriocarcinoma, Non-gestational / Q000097:blood / Q000150:complications / Q000175:diagnosis*; D006063:Chorionic Gonadotropin / Q000097:blood*; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D010051:Ovarian Neoplasms / Q000097:blood / Q000150:complications / Q000175:diagnosis*; D014057:Tomography, X-Ray Computed
chemical_list: D014408:Biomarkers, Tumor; D006063:Chorionic Gonadotropin