title: CD4(+)FoxP3(+) regulatory T-cells in human systemic lupus erythematosus.
abstract: Systemic lupus erythematosus (SLE) is a systemic autoimmune disease characterized by a loss of immune tolerance to self antigens and by the persistent production of pathogenic autoantibodies. Recent studies have suggested a dysregulation of regulatory T-cells (Tregs), particularly CD4(+)CD25(high)FoxP3(+) (forkhead box P3) Tregs, as one of the major factors conferring the risk for expression of human autoimmune diseases, including SLE. However, detailed studies of CD4(+)FoxP3(+) T-cells in patients with SLE remain limited. We attempt here to integrate the current experimental evidence to delineate the role of CD4(+)CD25(high) and other subsets of CD4(+)FoxP3(+) T-cells in human SLE.
authors.affiliation: Graduate Institute of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan, ROC.
authors.forename: Jau-Ling
authors.initials: JL
authors.lastname: Suen
authors.forename: Bor-Luen
authors.initials: BL
authors.lastname: Chiang
mesh_terms: D015704:CD4 Antigens / Q000276:immunology; D051858:Forkhead Transcription Factors / Q000276:immunology / Q000378:metabolism*; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000276:immunology* / Q000378:metabolism; D050378:T-Lymphocytes, Regulatory / Q000276:immunology* / Q000378:metabolism
chemical_list: D015704:CD4 Antigens; C418974:FOXP3 protein, human; D051858:Forkhead Transcription Factors