title: An assessment of the performance of elastography for the investigation of BI-RADS 4 and BI-RADS 5 breast lesions: correlations with pathological anatomy findings.
abstract: OBJECTIVE
  To study the diagnostic value of static elastography of the breast (score, histogram, quantitative ratio) in masses classed as BI-RADS 4 and BI-RADS 5 on sonography using the findings from pathological anatomy analyses on the masses as a reference.
  
  
  METHODS
  A prospective study using a representative sample into 68 masses seen on sonography and their elastography results. For each mass, we determined the elastography colourimetry score (UENO et al. classification, scores 1-3=benign and 4-5=malignant). We studied quantitative elastography parameters based on the Z2/Z1 (fat/lesion) ratio and a histogram showing the pattern of mass stiffness distribution. The results were compared with histology findings (68 lesions assessed, 22 benign lesions and 46 malignant lesions).
  
  
  RESULTS
  Elastography was consistent with histology (sensitivity: 73.9%, specificity: 86.4%, PPV: 91.9%, NPV: 61.3%). There were twelve false negatives and three false positives. With the Z2/Z1 ratio, we set a cut-off point of 3.05 for 99.0% specificity.
  
  
  CONCLUSIONS
  Elastography is a reliable technique that is able to assist radiologists in their diagnostic approach to breast pathology.
authors.affiliation: Department of Diagnostic and Interventional Radiology and Neuroradiology, Tours Regional University Hospital, François Rabelais University, Tours cedex, France.
authors.forename: M-L
authors.initials: ML
authors.lastname: Houelleu Demay
authors.forename: C
authors.initials: C
authors.lastname: Monghal
authors.forename: P
authors.initials: P
authors.lastname: Bertrand
authors.forename: A
authors.initials: A
authors.lastname: Vildé
authors.forename: L
authors.initials: L
authors.lastname: Brunereau
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001943:Breast Neoplasms / Q000000981:diagnostic imaging* / Q000473:pathology*; D054459:Elasticity Imaging Techniques; D005260:Female; D006801:Humans; D008875:Middle Aged; D011446:Prospective Studies; D055815:Young Adult