title: Structure of d(CCGGGACCGG)4 as a four-way junction at 1.6 Å resolution: new insights into solvent interactions.
abstract: The crystal structure of the decamer sequence d(CCGGGACCGG)(4) has previously been reported at 2.16 Å resolution as a four-way junction. Here, the structure of this sequence is reported at the significantly higher resolution of 1.6 Å, which is the highest resolution reported for a four-way junction. This allowed the unambiguous identification of an extensive hydration network with distinct patterns and solvent-mediated interactions that shed new light on the role of water in the formation and stabilization of junction structures.
authors.affiliation: CAS in Crystallography and Biophysics, University of Madras, Guindy Campus, Chennai, Tamil Nadu 600 025, India.
authors.forename: Arka
authors.initials: A
authors.lastname: Chakraborty
authors.forename: Pradeep Kumar
authors.initials: PK
authors.lastname: Mandal
authors.forename: Namasivayam
authors.initials: N
authors.lastname: Gautham
mesh_terms: D001483:Base Sequence; D008958:Models, Molecular; D009690:Nucleic Acid Conformation; D011119:Polynucleotides / Q000737:chemistry*; D012997:Solvents
chemical_list: D011119:Polynucleotides; D012997:Solvents