title: [Regulatory mechanism of bradykinin receptor in signal transduction and cardiovascular diseases].
abstract: Bradykinin receptors are an important member of the G protein-coupled receptors family. Bradykinin receptor-mediated signal transductions play a significant role in maintaining cardiovascular homeostasis, regulating pain and inflammation. In recent years, the introduction of fluorescence resonance energy transfer, bioluminescence resonance energy transfer and their extended technologies, confirmed that bradykinin receptors can exist in the formation of dimerizations or even high-order oligomers. Compared with the monomer, its signal transduction and pathological features have changed accordingly. In this paper, we overview how bradykinin receptor monomeric and dimers regulate physiological and pathological processes as well as the latest research techniques.
authors.affiliation: Qufu Normal University, Qufu 273165, China.
authors.forename: Lu-Lu
authors.initials: LL
authors.lastname: Liu
authors.forename: Xin
authors.initials: X
authors.lastname: Cai
authors.forename: Jing
authors.initials: J
authors.lastname: Chen
authors.forename: Bo
authors.initials: B
authors.lastname: Bai
mesh_terms: D000818:Animals; D060807:Bioluminescence Resonance Energy Transfer Techniques; D002318:Cardiovascular Diseases / Q000503:physiopathology*; D031541:Fluorescence Resonance Energy Transfer; D006801:Humans; D055503:Protein Multimerization / Q000502:physiology; D018002:Receptors, Bradykinin / Q000502:physiology*; D015398:Signal Transduction / Q000502:physiology*
chemical_list: D018002:Receptors, Bradykinin