title: A long-term outcome of therapeutic angiogenesis by transplantation of peripheral blood stem cells in critical limb ischemia after interventional revascularization.
abstract: A 61-year-old male patient with atherosclerotic critical limb ischemia in the left leg underwent stent insertion into the left superficial femoral artery. Stenting procedures improved Rutherford grade from III-5 to II-4. Granulocyte colony-stimulating factor stimulated the production of white blood cells over four-fold and mononuclear cells (MNCs) 1.5-fold in the whole blood. Transplantation of 7.9x10(9) autologous MNCs into the left femoral artery rapidly decreased the leg pain intensity, with further improvement of Rutherford grades from II-4 to 0-0 without any side effects. In the four-year follow-up, significant improvement was found in terms of ankle brachial index, from nondetectable to 0.67, and peak systolic velocity, from 14.8 to 36.1 cm/s. Limb salvage and decreased resting pain were the notable outcomes of the treatment.
authors.affiliation: School of Life and Health Sciences, Adikavi Nannaya University, Rajahmundry/AP, India.
authors.forename: Alavala Matta
authors.initials: AM
authors.lastname: Reddy
authors.forename: Byung Kook
authors.initials: BK
authors.lastname: Kwak
authors.forename: Hyung Jin
authors.initials: HJ
authors.lastname: Shim
authors.forename: Eui-Chan
authors.initials: EC
authors.lastname: Jang
authors.forename: Ae Ja
authors.initials: AJ
authors.lastname: Park
authors.forename: Eunkyung
authors.initials: E
authors.lastname: Park
authors.forename: Chiyoung
authors.initials: C
authors.lastname: Ahn
mesh_terms: D050197:Atherosclerosis / Q000150:complications; D003251:Constriction, Pathologic / Q000209:etiology / Q000601:surgery; D016638:Critical Illness; D005500:Follow-Up Studies; D006801:Humans; D007511:Ischemia / Q000209:etiology / Q000601:surgery*; D007866:Leg / Q000098:blood supply*; D023821:Limb Salvage / Q000379:methods; D008297:Male; D008875:Middle Aged; D018919:Neovascularization, Physiologic; D036102:Peripheral Blood Stem Cell Transplantation / Q000379:methods*; D015607:Stents; D014182:Transplantation, Autologous / Q000379:methods*; D016896:Treatment Outcome