title: Hepatocellular carcinoma in HIV positive patients.
abstract: Highly active antiretroviral therapy (HAART) has dramatically changed the natural history of HIV-1-infected patients leading to increased survival and a better quality of life. Hepatitis C virus (HCV) and hepatitis B virus (HBV) infections are common among HIV-1-infected subjects and represent the most important risk factors for hepatocellular carcinoma (HCC). Whether HIV plays a direct role in hepatocellular carcinoma (HCC) pathogenesis remains to be established.HCC clinical course depends on stage of cancer disease, performance status and comorbidities. Therapeutic options include liver transplantation, local antiblastic chemotherapy and biological drugs. In the HIV setting few data are available about treatment options. The increased longevity of patients with HIV imposes new strategies for prevention and therapeutic management of patients. The aim of this article is to provide an up-to-date review of HIV-related HCC in the HAART era.
authors.affiliation: Department of Clinical and Molecular Biomedicine, University of Catania, Catania, Italy. gnunnari@hotmail.com
authors.forename: G
authors.initials: G
authors.lastname: Nunnari
authors.forename: M
authors.initials: M
authors.lastname: Berretta
authors.forename: M R
authors.initials: MR
authors.lastname: Pinzone
authors.forename: M
authors.initials: M
authors.lastname: Di Rosa
authors.forename: S
authors.initials: S
authors.lastname: Berretta
authors.forename: G
authors.initials: G
authors.lastname: Cunsolo
authors.forename: M
authors.initials: M
authors.lastname: Malaguarnera
authors.forename: S
authors.initials: S
authors.lastname: Cosentino
authors.forename: P
authors.initials: P
authors.lastname: De Paoli
authors.forename: J M
authors.initials: JM
authors.lastname: Schnell
authors.forename: B
authors.initials: B
authors.lastname: Cacopardo
mesh_terms: D006528:Carcinoma, Hepatocellular / Q000209:etiology* / Q000517:prevention & control / Q000628:therapy; D060085:Coinfection; D006679:HIV Seropositivity / Q000150:complications*; D006509:Hepatitis B / Q000150:complications; D006526:Hepatitis C / Q000150:complications; D006801:Humans; D008113:Liver Neoplasms / Q000209:etiology* / Q000517:prevention & control / Q000628:therapy; D012307:Risk Factors