title: Common variants within 6p21.31 locus are associated with chronic lymphocytic leukaemia and, potentially, other non-Hodgkin lymphoma subtypes.
abstract: A recent meta-analysis of three genome-wide association studies of chronic lymphocytic leukaemia (CLL) identified two common variants at the 6p21.31 locus that are associated with CLL risk. To verify and further explore the association of these variants with other non-Hodgkin lymphoma (NHL) subtypes, we genotyped 1196 CLL cases, 1699 NHL cases, and 2410 controls. We found significant associations between the 6p21.31 variants and CLL risk (rs210134: P = 0·01; rs210142: P = 6·8 × 10(-3)). These variants also showed a trend towards association with some of the other NHL subtypes. Our results validate the prior work and support specific genetic pathways for risk among NHL subtypes.
authors.affiliation: Mayo Clinic College of Medicine, Rochester, MN, USA. slager@mayo.edu
authors.forename: Susan L
authors.initials: SL
authors.lastname: Slager
authors.forename: Nicola J
authors.initials: NJ
authors.lastname: Camp
authors.forename: Lucia
authors.initials: L
authors.lastname: Conde
authors.forename: Tait D
authors.initials: TD
authors.lastname: Shanafelt
authors.forename: Sara J
authors.initials: SJ
authors.lastname: Achenbach
authors.forename: Kari G
authors.initials: KG
authors.lastname: Rabe
authors.forename: Neil E
authors.initials: NE
authors.lastname: Kay
authors.forename: Anne J
authors.initials: AJ
authors.lastname: Novak
authors.forename: Timothy G
authors.initials: TG
authors.lastname: Call
authors.forename: Paige M
authors.initials: PM
authors.lastname: Bracci
authors.forename: Fenna M C
authors.initials: FM
authors.lastname: Sille
authors.forename: Sylvia
authors.initials: S
authors.lastname: Sanchez
authors.forename: Nicholas K
authors.initials: NK
authors.lastname: Akers
authors.forename: Julie M
authors.initials: JM
authors.lastname: Cunningham
authors.forename: Daniel J
authors.initials: DJ
authors.lastname: Serie
authors.forename: Shannon K
authors.initials: SK
authors.lastname: McDonnell
authors.forename: Jose F
authors.initials: JF
authors.lastname: Leis
authors.forename: Alice H
authors.initials: AH
authors.lastname: Wang
authors.forename: J Brice
authors.initials: JB
authors.lastname: Weinberg
authors.forename: Martha
authors.initials: M
authors.lastname: Glenn
authors.forename: Brian
authors.initials: B
authors.lastname: Link
authors.forename: Celine M
authors.initials: CM
authors.lastname: Vachon
authors.forename: Mark C
authors.initials: MC
authors.lastname: Lanasa
authors.forename: Christine F
authors.initials: CF
authors.lastname: Skibola
authors.forename: James R
authors.initials: JR
authors.lastname: Cerhan
mesh_terms: D016022:Case-Control Studies; D002896:Chromosomes, Human, Pair 6; D004273:DNA, Neoplasm / Q000235:genetics; D005819:Genetic Markers / Q000235:genetics; D055106:Genome-Wide Association Study; D005838:Genotype; D006801:Humans; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000235:genetics*; D008228:Lymphoma, Non-Hodgkin / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D050998:bcl-2 Homologous Antagonist-Killer Protein / Q000235:genetics
chemical_list: C494772:BAK1 protein, human; D004273:DNA, Neoplasm; D005819:Genetic Markers; D050998:bcl-2 Homologous Antagonist-Killer Protein