title: Random skin biopsy of intravascular large B-cell lymphoma: a case report.
abstract: A 72-year-old woman visited our clinic with fever of unknown origin above 38°C and arthralgia from 7 months before. Her symptoms recurred as oral steroid was reduced. Random skin biopsy was carried out from five points. One of the five specimens taken from abdomen revealed large atypical lymphoid cells in the vascular space of subcutaneous fat. Immunohistochemical analysis showed that these cells were positive for CD20, CD79a, bcl-2, bcl-6 and MUM-1. From these findings, a diagnosis of intravascular large B cell lymphoma was made.
authors.affiliation: Department of Dermatology, Tokai University School of Medicine, 143 Shimokasuya, Isehara, Kanagawa 259-1193, Japan. n-ikoma@is.icc.u-tokai.ac.jp
authors.forename: Norihiro
authors.initials: N
authors.lastname: Ikoma
authors.forename: Yasuaki
authors.initials: Y
authors.lastname: Manabe
authors.forename: Hanako
authors.initials: H
authors.lastname: Yamaoka
authors.forename: Emiko
authors.initials: E
authors.lastname: Akasaka
authors.forename: Tomotaka
authors.initials: T
authors.lastname: Mabuchi
authors.forename: Akira
authors.initials: A
authors.lastname: Ozawa
authors.forename: Naoya
authors.initials: N
authors.lastname: Nakamura
authors.forename: Minoru
authors.initials: M
authors.lastname: Kojima
authors.forename: Kiyoshi
authors.initials: K
authors.lastname: Ando
mesh_terms: D000368:Aged; D018951:Antigens, CD20 / Q000378:metabolism; D001706:Biopsy / Q000379:methods; D051925:CD79 Antigens / Q000378:metabolism; D004268:DNA-Binding Proteins / Q000378:metabolism; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D050835:Interferon Regulatory Factors / Q000378:metabolism; D016393:Lymphoma, B-Cell / Q000175:diagnosis* / Q000378:metabolism; D009361:Neoplasm Invasiveness / Q000175:diagnosis; D019253:Proto-Oncogene Proteins c-bcl-2 / Q000378:metabolism; D051560:Proto-Oncogene Proteins c-bcl-6; D012867:Skin / Q000098:blood supply / Q000473:pathology; D019043:Vascular Neoplasms / Q000175:diagnosis* / Q000378:metabolism; D000099218:Interferon Regulatory Factor-4
chemical_list: D018951:Antigens, CD20; D051925:CD79 Antigens; D004268:DNA-Binding Proteins; D050835:Interferon Regulatory Factors; D019253:Proto-Oncogene Proteins c-bcl-2; D051560:Proto-Oncogene Proteins c-bcl-6; D000099218:Interferon Regulatory Factor-4; C084103:BCL6 protein, human; C497881:CD79A protein, human