title: Efficacy of Hyalomma scupense (Hd86) antigen against Hyalomma excavatum and H. scupense tick infestations in cattle.
abstract: The Rhipicephalus microplus recombinant Bm86-based tick vaccines have shown their efficacy for the control of several Hyalomma cattle ticks genera, namely H. dromedarii and H. anatolicum. However, H. scupense species, the most important tick in North Africa has never been studied. Vaccination trials using either a recombinant Bm86-based vaccine or a recombinant Hd86-based vaccine (the Bm86 ortholog in H. scupense) were conducted in cattle against immature and adult H. scupense ticks and adult H. excavatum ticks. The results showed a 59.19% reduction in the number of scupense nymphs engorging on Hd86 vaccinated cattle. However, cattle vaccination with Bm86 or Hd86 did not have an effect on H. scupense or H. excavatum adult ticks infestations. These results showed that Hd86 vaccines are selectively effective against H. scupense immature instars and emphasize on an integrated anti-tick vaccine control in North Africa.
authors.affiliation: Laboratoire de Parasitologie, Ecole Nationale de Médecine Vétérinaire, Institution de la Recherche et de l'Enseignement Supérieur Agricoles and La Manouba University, 2020 Sidi Thabet, Tunisia. yousr.galai@pasteur.rns.tn
authors.forename: Yousr
authors.initials: Y
authors.lastname: Galaï
authors.forename: Mario
authors.initials: M
authors.lastname: Canales
authors.forename: Mourad
authors.initials: M
authors.lastname: Ben Saïd
authors.forename: Mohamed
authors.initials: M
authors.lastname: Gharbi
authors.forename: Moez
authors.initials: M
authors.lastname: Mhadhbi
authors.forename: Mohamed
authors.initials: M
authors.lastname: Jedidi
authors.forename: José
authors.initials: J
authors.lastname: de La Fuente
authors.forename: Mohamed-Aziz
authors.initials: MA
authors.lastname: Darghouth
mesh_terms: D000818:Animals; D002417:Cattle; D002418:Cattle Diseases / Q000276:immunology / Q000517:prevention & control*; D019476:Insect Proteins / Q000008:administration & dosage / Q000276:immunology*; D026863:Ixodidae / Q000472:pathogenicity*; D011994:Recombinant Proteins / Q000008:administration & dosage / Q000276:immunology; D013984:Tick Infestations / Q000276:immunology / Q000517:prevention & control*; D014611:Vaccination / Q000379:methods; D014614:Vaccines, Synthetic / Q000008:administration & dosage / Q000276:immunology
chemical_list: D019476:Insect Proteins; D011994:Recombinant Proteins; D014614:Vaccines, Synthetic