title: Analytical approaches for MCPD esters and glycidyl esters in food and biological samples: a review and future perspectives.
abstract: Esters of 2 - and 3-monochloropropane-1,2-diol (MCPD) and glycidol esters are important contaminants of processed edible oils used as foods or food ingredients. This review describes the occurrence and analysis of MCPD esters and glycidol esters in vegetable oils and some other foods. The focus is on the analytical methods based on both direct and indirect methods. Methods of analysis applied to oils and lipid extracts of foods have been based on transesterification to free MCPD and determination by gas chromatography-mass spectrometry (indirect methods) and by high-performance liquid chromatography-mass spectrometry (direct methods). The evolution and performance of the different methods is described and their advantages and disadvantages are discussed. The application of direct and indirect methods to the analysis of foods and to research studies is described. The metabolism and fate of MCPD esters and glycidol esters in biological systems and the methods used to study these in body tissues studies are described. A clear understanding of the chemistry of the methods is important when choosing those suitable for the desired application, and will contribute to the mitigation of these contaminants.
authors.affiliation: The Food and Environment Research Agency (FERA), Sand Hutton, York YO41 1LZ, UK.
authors.forename: C
authors.initials: C
authors.lastname: Crews
authors.forename: A
authors.initials: A
authors.lastname: Chiodini
authors.forename: M
authors.initials: M
authors.lastname: Granvogl
authors.forename: C
authors.initials: C
authors.lastname: Hamlet
authors.forename: K
authors.initials: K
authors.lastname: Hrnčiřík
authors.forename: J
authors.initials: J
authors.lastname: Kuhlmann
authors.forename: A
authors.initials: A
authors.lastname: Lampen
authors.forename: G
authors.initials: G
authors.lastname: Scholz
authors.forename: R
authors.initials: R
authors.lastname: Weisshaar
authors.forename: T
authors.initials: T
authors.lastname: Wenzl
authors.forename: P R
authors.initials: PR
authors.lastname: Jasti
authors.forename: W
authors.initials: W
authors.lastname: Seefelder
mesh_terms: D002273:Carcinogens / Q000737:chemistry / Q000633:toxicity*; D004852:Epoxy Compounds / Q000737:chemistry*; D004952:Esters / Q000737:chemistry / Q000633:toxicity*; D005504:Food Analysis / Q000379:methods*; D005506:Food Contamination; D010938:Plant Oils / Q000737:chemistry*; D020005:Propanols / Q000737:chemistry*
chemical_list: D002273:Carcinogens; D004852:Epoxy Compounds; D004952:Esters; D010938:Plant Oils; D020005:Propanols; C004312:glycidol