title: Evaluation of polyurethane based on cellulose derivative-ketoprofen biosystem for implant biomedical devices.
abstract: A polyether-urethane based on polytetrahydrofuran containing hydroxypropyl cellulose for biomedical applications was tested for its biocompatibility. Ketoprofen was incorporated (3% and 6%) in the polyurethane matrix as an anti-inflammatory drug. Dynamic vapour sorption method was employed for testing the water sorption/desorption behaviour of these materials with the determination of the surface isotherms, surface parameters and the kinetic curves of sorption/desorption processes. Cytotoxicity testing in vitro for quantifying cell proliferation was employed, and the results evidence noncytotoxicity for the studied polyurethane-drug systems. In vivo biocompatibility study was performed on 200 g weight male rats. It was found that after implantation of the polyether-urethane samples a reduced acute inflammation occurred, especially for polyurethane samples with added ketoprofen.
authors.affiliation: Petru Poni Institute of Macromolecular Chemistry, 41A Grigore Ghica Voda Alley, 700487 Iasi, Romania. eradro2002@yahoo.com
authors.forename: Doina
authors.initials: D
authors.lastname: Macocinschi
authors.forename: Daniela
authors.initials: D
authors.lastname: Filip
authors.forename: Stelian
authors.initials: S
authors.lastname: Vlad
authors.forename: Maria
authors.initials: M
authors.lastname: Butnaru
authors.forename: Laura
authors.initials: L
authors.lastname: Knieling
mesh_terms: D020341:Absorbable Implants; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000737:chemistry / Q000494:pharmacology; D049109:Cell Proliferation; D002478:Cells, Cultured; D002482:Cellulose / Q000737:chemistry / Q000494:pharmacology; D006801:Humans; D007249:Inflammation / Q000517:prevention & control; D007660:Ketoprofen / Q000737:chemistry / Q000494:pharmacology; D008297:Male; D008422:Materials Testing; D011140:Polyurethanes / Q000737:chemistry / Q000494:pharmacology; D051381:Rats
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D011140:Polyurethanes; D002482:Cellulose; D007660:Ketoprofen