title: Therapeutic potential of thymosin β4 in myocardial infarct and heart failure.
abstract: Thymosin β4 (Tβ4) is a peptide known for its abilities to protect and facilitate regeneration in a number of tissues following injury. Its cardioprotective effects have been evaluated in different animal models and, currently, a clinical trial is being planned in patients suffering from acute myocardial infarction. This paper focuses on the effects of Tβ4 on cardiac function in animal studies utilizing different imaging modalities for outcome measurements.
authors.affiliation: Department of Surgery, Turku University Central Hospital, Turku, Finland. christoffer.stark@utu.fi
authors.forename: Christoffer
authors.initials: C
authors.lastname: Stark
authors.forename: Pekka
authors.initials: P
authors.lastname: Taimen
authors.forename: Miikka
authors.initials: M
authors.lastname: Tarkia
authors.forename: Jussi
authors.initials: J
authors.lastname: Pärkkä
authors.forename: Antti
authors.initials: A
authors.lastname: Saraste
authors.forename: Tero-Pekka
authors.initials: TP
authors.lastname: Alastalo
authors.forename: Timo
authors.initials: T
authors.lastname: Savunen
authors.forename: Juha
authors.initials: J
authors.lastname: Koskenvuo
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D006333:Heart Failure / Q000188:drug therapy* / Q000378:metabolism*; D006801:Humans; D009203:Myocardial Infarction / Q000188:drug therapy* / Q000378:metabolism*; D013947:Thymosin / Q000378:metabolism* / Q000627:therapeutic use*; D000099201:Thymosin beta(4)
chemical_list: D013947:Thymosin; D000099201:Thymosin beta(4)