title: Biological evolution in a multidimensional fitness landscape.
abstract: We considered a multiblock molecular model of biological evolution, in which fitness is a function of the mean types of alleles located at different parts (blocks) of the genome. We formulated an infinite population model with selection and mutation, and calculated the mean fitness. For the case of recombination, we formulated a model with a multidimensional fitness landscape (the dimension of the space is equal to the number of blocks) and derived a theorem about the dynamics of initially narrow distribution. We also considered the case of lethal mutations. We also formulated the finite population version of the model in the case of lethal mutations. Our models, derived for the virus evolution, are interesting also for the statistical mechanics and the Hamilton-Jacobi equation as well.
authors.affiliation: Institute of Physics, Academia Sinica, Nankang, Taipei 11529, Taiwan. saakian@phys.sinica.edu.tw
authors.forename: David B
authors.initials: DB
authors.lastname: Saakian
authors.forename: Zara
authors.initials: Z
authors.lastname: Kirakosyan
authors.forename: Chin-Kun
authors.initials: CK
authors.lastname: Hu
mesh_terms: D019143:Evolution, Molecular; D056084:Genetic Fitness; D008957:Models, Genetic; D009154:Mutation / Q000235:genetics; D011995:Recombination, Genetic / Q000235:genetics