title: An observational study of the initial management of hypothyroidism in France: the ORCHIDÉE study.
abstract: OBJECTIVE
  To document the initial management of hypothyroidism in France with respect to diagnostic setting, investigations, and therapeutic approach.
  
  
  METHODS
  Observational study of the management by primary care practitioners (PCPs) and endocrinologists of patients diagnosed with, and treated for, hypothyroidism during the enrollment period or the previous 6 months.
  
  
  METHODS
  A representative sample of PCPs and endocrinologists enrolled up to five consecutive patients and reported sociodemographic, clinical, therapeutic, and laboratory data. Data were submitted at baseline and at the first measurement of TSH after starting the treatment.
  
  
  RESULTS
  The analysis population comprised 1255 patients (mean (s.d.) age 52.8 (16.3) years; 84% female). Hypothyroidism was suspected on clinical grounds in 77% of patients, with goiter in 16%. Autoimmune thyroiditis, supported by positive anti-thyroid antibodies, was the most frequent diagnosis (59%), followed by iatrogenic causes (28%), of which thyroidectomy was the most common. The median baseline TSH was 8.6 mIU/l, suggesting a high incidence of subclinical hypothyroidism. Imaging studies were requested in over 75% of patients, with ultrasound performed in 98% and scintigraphy performed in 19% of these patients. Both groups of physicians treated their patients almost exclusively with levothyroxine. Endocrinologists were more likely than PCPs to provide counseling on how to take medication correctly.
  
  
  CONCLUSIONS
  This observational study of a large cohort of patients with newly diagnosed hypothyroidism in France illustrates current practice and indicates some areas where physician education may be required to optimize adherence to guidelines and cost-effectiveness.
authors.affiliation: Endocrinology, Hôpital Robert Debré, 45 Rue Cognacq Jay, 51100 Reims, France. bdelemer@chu-reims.fr
authors.forename: Brigitte
authors.initials: B
authors.lastname: Delemer
authors.forename: Jean-Pierre
authors.initials: JP
authors.lastname: Aubert
authors.forename: Pierre
authors.initials: P
authors.lastname: Nys
authors.forename: Frédéric
authors.initials: F
authors.lastname: Landron
authors.forename: Stéphane
authors.initials: S
authors.lastname: Bouée
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002648:Child; D019468:Disease Management; D005260:Female; D005602:France; D006042:Goiter / Q000175:diagnosis / Q000188:drug therapy; D006801:Humans; D007037:Hypothyroidism / Q000175:diagnosis* / Q000188:drug therapy; D008297:Male; D008875:Middle Aged; D058007:Physicians, Primary Care; D013967:Thyroiditis, Autoimmune / Q000175:diagnosis / Q000188:drug therapy; D013974:Thyroxine / Q000627:therapeutic use; D055815:Young Adult
chemical_list: D013974:Thyroxine