title: Single-donor allogeneic platelet fibrin glue and osteoconductive scaffold in orbital floor fracture reconstruction.
abstract: BACKGROUND
  Commonly used materials for orbital floor fracture reconstruction include autologous cranial bone graft and titanium mesh. We have evaluated here a biomaterial combining biphasic calcium phosphate (hydroxyapatite [HA]/β-tricalcium phosphate [TCP]) osteoconductive scaffold with single-donor allogeneic platelet fibrin glue.
  
  
  METHODS
  The study was conducted on 10 consecutive patients with a follow-up of up to 4 years. Platelet fibrin glue was prepared by mixing equal volumes of single-donor platelet-rich plasma and cryoprecipitate with HA/β-TCP followed by activation with human thrombin prepared by plasma activation. Postoperative evaluations included serial photographs, repeated physical examination, and 3-dimensional computed tomography scan performed 2 years after surgery.
  
  
  RESULTS
  The fibrin-rich platelet biomaterial was easy to mold and to apply on the surgical site allowing the surgeon to sculpt accurately the bone defect, providing mechanical stability while avoiding spillage of the scaffold. No infection of the orbit or extrusion of HA/β-TCP was observed. Ocular motility was normal, and no diplopia or enophthalmos of the injured orbit was noted. Coronal computed tomography scans of the reconstructed orbits revealed good restoration of the orbital floor defect in all 10 patients.
  
  
  CONCLUSIONS
  The use of single-donor platelet fibrin glue combined with an osteoconductive scaffold offers a valuable alternative to autologous cranial bone graft or titanium mesh in the reconstruction of orbital floor bone defect.
authors.affiliation: National Defense Medical Center, Division of Plastic Surgery, Department of Surgery, Tri-Service General Hospital, Taipei, Taiwan.
authors.forename: Tim-Mo
authors.initials: TM
authors.lastname: Chen
authors.forename: Yuan-Sheng
authors.initials: YS
authors.lastname: Tzeng
authors.forename: Jui-Che
authors.initials: JC
authors.lastname: Tsai
authors.forename: Thierry
authors.initials: T
authors.lastname: Burnouf
mesh_terms: D000328:Adult; D001672:Biocompatible Materials; D001792:Blood Platelets; D045424:Complex Mixtures / Q000627:therapeutic use*; D005169:Factor VIII; D005260:Female; D015718:Fibrin Tissue Adhesive; D005340:Fibrinogen; D006801:Humans; D006882:Hydroxyapatites; D008297:Male; D008422:Materials Testing; D008875:Middle Aged; D009917:Orbital Fractures / Q000628:therapy*; D019736:Prostheses and Implants; D019651:Plastic Surgery Procedures / Q000379:methods*; D054457:Tissue Scaffolds; D055815:Young Adult
chemical_list: D001672:Biocompatible Materials; D045424:Complex Mixtures; D015718:Fibrin Tissue Adhesive; D006882:Hydroxyapatites; C026912:cryoprecipitate coagulum; C074950:hydroxyapatite-beta tricalcium phosphate; D005169:Factor VIII; D005340:Fibrinogen