title: Therapeutic effects of α-iso-cubebenol, a natural compound isolated from the Schisandra chinensis fruit, against sepsis.
abstract: α-Iso-cubebenol, a natural compound isolated from the Schisandra chinensis fruit, strongly enhances survival rate in cecal ligation and puncture (CLP) challenge-induced sepsis. Mechanistically, α-iso-cubebenol markedly reduces viable bacteria in the peritoneal fluid and peripheral blood, by increasing production of superoxide anion. α-Iso-cubebenol also significantly attenuates widespread immune cell apoptosis in a mouse CLP sepsis model, and inhibits the production of proinflammatory cytokines including interleukin-1β (IL-1β) and IL-6 in CLP mice and lipopolysaccharide-stimulated splenocytes. Taken together, the results indicate that α-iso-cubebenol can reverse the progression of septic shock by triggering multiple protective downstream signaling pathways to enhance microbial killing and maintain organ function and leukocyte survival.
authors.affiliation: Department of Biological Sciences, Sungkyunkwan University, Suwon 440-746, South Korea.
authors.forename: Sung Kyun
authors.initials: SK
authors.lastname: Lee
authors.forename: Sang Doo
authors.initials: SD
authors.lastname: Kim
authors.forename: Minsoo
authors.initials: M
authors.lastname: Kook
authors.forename: Ha Young
authors.initials: HY
authors.lastname: Lee
authors.forename: Joon Seong
authors.initials: JS
authors.lastname: Park
authors.forename: Young Hoon
authors.initials: YH
authors.lastname: Park
authors.forename: Jum Soon
authors.initials: JS
authors.lastname: Kang
authors.forename: Won Jung
authors.initials: WJ
authors.lastname: Jung
authors.forename: Young Whan
authors.initials: YW
authors.lastname: Choi
authors.forename: Yoe-Sik
authors.initials: YS
authors.lastname: Bae
mesh_terms: D000818:Animals; D001419:Bacteria / Q000187:drug effects; D001688:Biological Products / Q000627:therapeutic use*; D004195:Disease Models, Animal; D005638:Fruit / Q000737:chemistry; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D032141:Schisandra / Q000737:chemistry*; D018805:Sepsis / Q000188:drug therapy*; D012717:Sesquiterpenes / Q000008:administration & dosage / Q000627:therapeutic use*
chemical_list: D001688:Biological Products; D012717:Sesquiterpenes; C571662:alpha-iso-cubebenol