title: Pituitary origin of persistently elevated human chorionic gonadotropin in a patient with gonadal failure.
abstract: OBJECTIVE
  To report a case of persistently elevated low levels of hCG to increase awareness of pituitary origin of persistently elevated hCG in patients with gonadal failure.
  
  
  METHODS
  Case report and literature review.
  
  
  METHODS
  Large university-affiliated infertility practice.
  
  
  METHODS
  A 16-year-old patient with primary amenorrhea, normal secondary sex characteristics, ovarian failure, and a 46,XY karyotype. Her past medical history was significant for focal segmental glomerulosclerosis, leading to a diagnosis of Frasier syndrome.
  
  
  METHODS
  At age 31 years, she desired pregnancy by oocyte donation and was found to have persistently elevated low levels of hCG (>35 mIU/mL).
  
  
  METHODS
  Pituitary hCG.
  
  
  RESULTS
  Both serum free β-hCG and hyperglycosylated hCG were undetectable. Total serum hCG diluted appropriately was not blocked by blocking agent and was detected in the urine. Subsequent treatment with exogenous E(2), in preparation of a donor oocyte cycle, suppressed her hCG levels (down to 8 mIU/mL). These results indicated a pituitary source of the serum hCG.
  
  
  CONCLUSIONS
  This report reinforces the need to consider pituitary hCG as the origin of persistently elevated hCG levels in patients with gonadal failure. Although levels of hCG <14 mIU/mL have been considered normal in postmenopausal women, our case suggests that patients with gonadal failure at younger ages might have a higher pituitary output of hCG.
authors.affiliation: Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, University of Vermont College of Medicine, Burlington, Vermont.
authors.forename: Zaher
authors.initials: Z
authors.lastname: Merhi
authors.affiliation: Division of Reproductive Endocrinology and Infertility, Department of Obstetrics & Gynecology and Women's Health, Albert Einstein College of Medicine, Montefiore Medical Center, Bronx, New York. Electronic address: staci.pollack@einstein.yu.edu.
authors.forename: Staci E
authors.initials: SE
authors.lastname: Pollack
mesh_terms: D000328:Adult; D006063:Chorionic Gonadotropin / Q000097:blood*; D005260:Female; D005307:Fertilization in Vitro; D052159:Frasier Syndrome / Q000097:blood / Q000175:diagnosis; D040181:Genetic Diseases, X-Linked / Q000097:blood* / Q000175:diagnosis; D006059:Gonadal Dysgenesis / Q000097:blood* / Q000175:diagnosis; D006801:Humans; D007247:Infertility, Female; D018587:Oocyte Donation; D010902:Pituitary Gland / Q000378:metabolism*
chemical_list: D006063:Chorionic Gonadotropin