title: Effect of high-dose oral rabeprazole on recurrent bleeding after endoscopic treatment of bleeding peptic ulcers.
abstract: Background. The aim of this study was to compare the effect of high-dose oral rabeprazole versus high-dose IV PPI on rebleeding after endoscopic treatment of bleeding peptic ulcers. Methods. This was a two-center, prospective, randomized, controlled trial. Patients with a high-risk bleeding peptic ulcer had endoscopic hemostasis and were randomly assigned to the high-dose oral rabeprazole group (20 mg twice daily for 72 hours) or the high-dose IV omeprazole group (80 mg as a bolus injection followed by continuous infusion at 8 mg/h for 72 hours). Results. The study was stopped because of slow enrollment (total n = 106). The rebleeding rates within 3 days were 3.7% (2 of 54 patients) given oral rabeprazole and 1.9% (1 of 52 patients) given IV omeprazole (P = 1.000). The rebleeding rates after 3 days were 1.9% and 0% (P = 1.000), respectively. The surgical intervention rates were 3.7% and 0% (P = 0.495), and the mortality rates were 1.9% and 0% (P = 1.000), respectively. Conclusions. The effect of high-dose oral rabeprazole did not differ significantly from that of high-dose IV omeprazole on rebleeding, surgical intervention, or mortality after endoscopic treatment of bleeding peptic ulcers, but this requires further evaluation.
authors.affiliation: Division of Gastroenterology, Department of Internal Medicine, The Catholic University of Korea College of Medicine, Uijeongbu St. Mary's Hospital, 65-1 Geumo-dong, Kyunggi-do, Uijeongbu City 480-717, Republic of Korea.
authors.forename: Hyung-Keun
authors.initials: HK
authors.lastname: Kim
authors.forename: Jin-Soo
authors.initials: JS
authors.lastname: Kim
authors.forename: Tae-Ho
authors.initials: TH
authors.lastname: Kim
authors.forename: Chang-Whan
authors.initials: CW
authors.lastname: Kim
authors.forename: Young-Seok
authors.initials: YS
authors.lastname: Cho
authors.forename: Sung-Soo
authors.initials: SS
authors.lastname: Kim
authors.forename: Hiun-Suk
authors.initials: HS
authors.lastname: Chae
authors.forename: Sok-Won
authors.initials: SW
authors.lastname: Han
authors.forename: Yong-Wan
authors.initials: YW
authors.lastname: Park
authors.forename: Hye-Suk
authors.initials: HS
authors.lastname: Son
authors.forename: Jeong-Yo
authors.initials: JY
authors.lastname: Min
authors.forename: Guen-Jong
authors.initials: GJ
authors.lastname: Cho
authors.forename: Jung-Sun
authors.initials: JS
authors.lastname: Bag
authors.forename: Son-Ook
authors.initials: SO
authors.lastname: Choi