title: A facile fabrication of spherical and beanpod-like magnetic-fluorescent particles with targeting functionalities.
abstract: Magnetic-fluorescent particles with targeting functionalities were fabricated by a modified Stöber method and two shapes (spherical and beanpod-like) were obtained by simply tuning the reaction temperature. The two multifunctional probes combined the useful functions of magnetism, fluorescence and FA (folic acid)-targeting recognition into one entity. The products were characterized by scanning electron microscopy, transmission electron microscopy, photoluminescence spectroscopy, confocal laser scanning microscopy, by a superconducting quantum interference device and by Fourier transform infrared spectroscopy. The experimental results show that the products possessed rapid magnetic response, relatively strong fluorescent signal, higher photostability and FA-targeting recognition as well as good water-dispersibility, suggesting that they would have potential medical applications in biolabeling and bioimaging.
authors.affiliation: State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, People's Republic of China.
authors.forename: Yan-Lin
authors.initials: YL
authors.lastname: Liu
authors.forename: Ji-Lin
authors.initials: JL
authors.lastname: Zhang
authors.forename: Gong
authors.initials: G
authors.lastname: Cheng
authors.forename: Guang-Yan
authors.initials: GY
authors.lastname: Hong
authors.forename: Jia-Zuan
authors.initials: JZ
authors.lastname: Ni
mesh_terms: D005492:Folic Acid / Q000737:chemistry; D008280:Magnetics; D018613:Microscopy, Confocal; D053758:Nanoparticles / Q000737:chemistry* / Q000648:ultrastructure; D036103:Nanotechnology / Q000379:methods*; D013050:Spectrometry, Fluorescence; D017550:Spectroscopy, Fourier Transform Infrared
chemical_list: D005492:Folic Acid