title: Interleukin 7 (IL-7) selectively promotes mouse and human IL-17-producing γδ cells.
abstract: IL-17-producing CD27(-) γδ cells (γδ(27-) cells) are widely viewed as innate immune cells that make critical contributions to host protection and autoimmunity. However, factors that promote them over IFN-γ-producing γδ(27+) cells are poorly elucidated. Moreover, although human IL-17-producing γδ cells are commonly implicated in inflammation, such cells themselves have proved difficult to isolate and characterize. Here, murine γδ(27-) T cells and thymocytes are shown to be rapidly and substantially expanded by IL-7 in vitro and in vivo. This selectivity owes in substantial part to the capacity of IL-7 to activate STAT3 in such cells. Additionally, IL-7 promotes strong responses of IL-17-producing γδ cells to TCR agonists, thus reemphasizing the cells' adaptive and innate potentials. Moreover, human IL-17-producing γδ cells are also substantially expanded by IL-7 plus TCR agonists. Hence, IL-7 has a conserved potential to preferentially regulate IL-17-producing γδ cells, with both biological and clinical implications.
authors.affiliation: London Research Institute,  Cancer Research UK, London WC2A 3LY,  United Kingdom.
authors.forename: Marie-Laure
authors.initials: ML
authors.lastname: Michel
authors.forename: Dick J
authors.initials: DJ
authors.lastname: Pang
authors.forename: Syeda F Y
authors.initials: SF
authors.lastname: Haque
authors.forename: Alexandre J
authors.initials: AJ
authors.lastname: Potocnik
authors.forename: Daniel J
authors.initials: DJ
authors.lastname: Pennington
authors.forename: Adrian C
authors.initials: AC
authors.lastname: Hayday
mesh_terms: D000818:Animals; D002478:Cells, Cultured; D006801:Humans; D020381:Interleukin-17 / Q000096:biosynthesis*; D015851:Interleukin-7 / Q000502:physiology*; D051379:Mice; D016692:Receptors, Antigen, T-Cell, gamma-delta / Q000276:immunology*; D013601:T-Lymphocytes / Q000378:metabolism*
chemical_list: D020381:Interleukin-17; D015851:Interleukin-7; D016692:Receptors, Antigen, T-Cell, gamma-delta