title: Automated assessment of heart chamber volumes and function in patients with previous myocardial infarction using multidetector computed tomography.
abstract: BACKGROUND
  Left ventricular (LV), right ventricular (RV), and left atrial (LA) volumes and functions contain important prognostic information in ischemic heart disease. Because multidetector computed tomography (MDCT) has high spatial resolution, this method may be optimal to obtain this information.
  
  
  OBJECTIVE
  We evaluated automated assessment for MDCT, by comparing it with cardiac magnetic resonance (CMR).
  
  
  METHODS
  Fifty-three patients with previous myocardial infarction were scanned with 1.5 Tesla CMR and 64-slice MDCT. End-diastolic volume, end-systolic volume, stroke volume, and ejection fraction (EF) were assessed for the left and right ventricle with automatic MDCT software and manual CMR software. LV myocardial mass and cyclic changes in LA volume were derived.
  
  
  RESULTS
  The mean age of patients was 61 ± 10 years, 40 (75%) were men. Automated MDCT segmentation was possible in all but 2 patients. The average duration of image processing was 21 ± 4 minutes by CMR and 11 ± 4 minutes by MDCT. Bland-Altman plots showed good agreement between MDCT and CMR with only small bias. LVEF by CMR was 56% ± 10% and by MDCT 61% ± 11%, mean difference of -5% (limits of agreement, -18% to 8%), and P < 0.001. RVEF by CMR was 60% ± 5% and by MDCT 56% ± 8%, mean difference of 5% (limits of agreement, -10% to 20%), and P < 0.001. LA fractional change by CMR was 49% ± 9% and by MDCT 45% ± 9%, mean difference of 4% (limits of agreement, -12% to 20%), and P ≤ 0.001.
  
  
  CONCLUSIONS
  LV, RV, and LA volumes and functions may be evaluated fast and reliably with the use of automated assessment and cardiac MDCT, with good agreement to CMR. Accurate assessment of cardiac chambers with MDCT appears possible in clinical practice.
authors.affiliation: Department of Cardiology 2012, The Heart Centre, University of Copenhagen, Blegdamsvej 9, Copenhagen East DK-2100, Denmark. mck601@alumni.ku.dk
authors.forename: Andreas
authors.initials: A
authors.lastname: Fuchs
authors.forename: Jørgen Tobias
authors.initials: JT
authors.lastname: Kühl
authors.forename: Jacob
authors.initials: J
authors.lastname: Lønborg
authors.forename: Thomas
authors.initials: T
authors.lastname: Engstrøm
authors.forename: Niels
authors.initials: N
authors.lastname: Vejlstrup
authors.forename: Lars
authors.initials: L
authors.lastname: Køber
authors.forename: Klaus F
authors.initials: KF
authors.lastname: Kofoed
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D016279:Atrial Function, Left; D002306:Cardiac Volume; D005260:Female; D006321:Heart / Q000000981:diagnostic imaging* / Q000503:physiopathology*; D006325:Heart Atria / Q000000981:diagnostic imaging / Q000473:pathology; D006352:Heart Ventricles / Q000000981:diagnostic imaging / Q000473:pathology; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D008875:Middle Aged; D061330:Multidetector Computed Tomography; D009203:Myocardial Infarction / Q000000981:diagnostic imaging* / Q000473:pathology / Q000503:physiopathology*; D009206:Myocardium / Q000473:pathology; D015588:Observer Variation; D011446:Prospective Studies; D015203:Reproducibility of Results; D016277:Ventricular Function, Left; D016278:Ventricular Function, Right