title: Japonicones Q-T, four new dimeric sesquiterpene lactones from Inula japonica Thunb.
abstract: Four new dimeric sesquiterpene lactones (japonicones Q-T, 1-4) were isolated from the aerial part of Inula japonica Thunb., together with two known ones. Their structures were determined mainly by 1D and 2D NMR spectroscopic techniques including HSQC, (1)H-H COSY, HMBC, and NOESY. Herein, the inhibitory activities against lipopolysaccharide (LPS)-induced nitric oxide (NO) production in RAW264.7 macrophages of 1-6 were evaluated; IC(50) values were tested as 8.5, 8.9, 4.3, 4.3, 4.2, and 9.2μM, respectively.
authors.affiliation: School of Pharmacy, Shanghai Jiao Tong University, Shanghai 200240, PR China.
authors.forename: Jia Xian
authors.initials: JX
authors.lastname: Zhu
authors.forename: Jiang Jiang
authors.initials: JJ
authors.lastname: Qin
authors.forename: Hui Zi
authors.initials: HZ
authors.lastname: Jin
authors.forename: Wei Dong
authors.initials: WD
authors.lastname: Zhang
mesh_terms: D000818:Animals; D038143:Inula / Q000737:chemistry*; D007783:Lactones / Q000737:chemistry*; D008958:Models, Molecular; D015394:Molecular Structure; D035261:Plant Components, Aerial / Q000737:chemistry; D012717:Sesquiterpenes / Q000737:chemistry*
chemical_list: D007783:Lactones; D012717:Sesquiterpenes