title: Lack of methylation in the upstream region of human papillomavirus type 6 from aerodigestive tract papillomas.
abstract: Methylation of the high-risk human papillomavirus type 16 (HPV16) upstream regulatory region (URR) has been described, but whether methylation is present among low-risk HPVs is unknown. The methylation status of the HPV6 URR was analyzed in papillomas from the upper aerodigestive tract of six adult patients. All CpGs in the URR were unmethylated, from both basal/intermediate and superficial cells, suggesting that methylation is not involved in the regulation of transcription from the HPV6 URR, regardless of epithelial differentiation.
authors.affiliation: Department of Laboratory Medicine, Section of Medical Microbiology, Lund University, Malmö, Sweden.
authors.forename: Agustín Enrique
authors.initials: AE
authors.lastname: Ure
authors.forename: Ola
authors.initials: O
authors.lastname: Forslund
mesh_terms: D000328:Adult; D000368:Aged; D019175:DNA Methylation; D005260:Female; D006801:Humans; D007822:Laryngeal Neoplasms / Q000821:virology*; D008297:Male; D008875:Middle Aged; D008969:Molecular Sequence Data; D010212:Papilloma / Q000821:virology*; D027383:Papillomaviridae / Q000145:classification / Q000235:genetics* / Q000302:isolation & purification; D010610:Pharyngeal Neoplasms / Q000821:virology*; D010802:Phylogeny