title: Change in general and central adiposity measures in prediction of incident dysglycemia; Tehran Lipid and Glucose Study.
abstract: OBJECTIVE
  To examine the change in general and central adiposity measures as a predictor of incident dysglycemia during a 6-year follow-up.
  
  
  METHODS
  A total of 4029 (2333 women and 1696 men) non-dysglycemic Iranians aged ≥ 20 years, underwent standard fasting and 2-h post-challenge plasma glucose tests at baseline and follow-up.
  
  
  RESULTS
  During follow-up, 458 new cases of dysglycemia occurred. In multivariable models including baseline values of each anthropometric measure, odds ratios (ORs) for dysglycemia incidence corresponding to a 1-SD increase in changes of body mass index (BMI), waist circumference (WC), waist-to-hip ratio (WHR), waist-to-height ratio (WHtR) and hip circumference (HC), were 1.32, 1.56, 1.39, 1.51 and 1.39 for men and 1.59, 1.50, 1.37, 1.47, and 1.38, for women, respectively (all P<0.05). After controlling for weight change and WC change among men and women, respectively, HC change did not remain as a predictor. Using the paired homogeneity test, there was no superiority for changes in central obesity measures compared to changes in BMI to predict dysglycemia.
  
  
  CONCLUSIONS
  The association between HC changes and incident dysglycemia was dependent upon changes in central and general adiposity measures, where the former did not have higher predictability than the latter in prediction of dysglycemia.
authors.affiliation: Prevention of Metabolic Disorders Research Center, Research Institute for Endocrine Sciences (RIES), Shahid Beheshti University of Medical Sciences, Tehran, Iran. fzhadaegh@endocrine.ac.ir
authors.forename: Farzad
authors.initials: F
authors.lastname: Hadaegh
authors.forename: Younes
authors.initials: Y
authors.lastname: Jahangiri Noudeh
authors.forename: Maryam
authors.initials: M
authors.lastname: Tohidi
authors.forename: Nasibeh
authors.initials: N
authors.lastname: Vatankhah
authors.forename: Davood
authors.initials: D
authors.lastname: Khalili
authors.forename: Reza
authors.initials: R
authors.lastname: Mohebi
authors.forename: Fereidoun
authors.initials: F
authors.lastname: Azizi
mesh_terms: D050154:Adiposity / Q000502:physiology*; D000328:Adult; D001786:Blood Glucose / Q000032:analysis*; D015992:Body Mass Index; D005260:Female; D044882:Glucose Metabolism Disorders / Q000453:epidemiology*; D006801:Humans; D015994:Incidence; D007492:Iran / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D012307:Risk Factors; D055105:Waist Circumference / Q000502:physiology*; D049629:Waist-Hip Ratio
chemical_list: D001786:Blood Glucose