title: Treatment of guanfacine toxicity with naloxone.
abstract: We describe a 4-year-old boy who presents to the emergency department with lethargy, bradycardia, and initial hypertension followed by hypotension due to guanfacine toxicity after ingestion of standard doses of the extended release formulation. This is the first case report to describe the use of naloxone to treat these symptoms and document improvements in level of consciousness, blood pressure, and heart rate associated with this therapy.
authors.affiliation: Division of Pediatric Emergency Medicine, Department of Pediatrics, Columbia University College of Physicians and Surgeons, New York, NY, USA. dst2141@columbia.edu
authors.forename: Daniel S
authors.initials: DS
authors.lastname: Tsze
authors.forename: Peter S
authors.initials: PS
authors.lastname: Dayan
mesh_terms: D000959:Antihypertensive Agents / Q000009:adverse effects / Q000627:therapeutic use; D001289:Attention Deficit Disorder with Hyperactivity / Q000188:drug therapy / Q000503:physiopathology; D001794:Blood Pressure / Q000187:drug effects; D002675:Child, Preschool; D004562:Electrocardiography; D005500:Follow-Up Studies; D016316:Guanfacine / Q000009:adverse effects* / Q000627:therapeutic use; D006801:Humans; D007022:Hypotension / Q000139:chemically induced / Q000188:drug therapy* / Q000503:physiopathology; D008297:Male; D009270:Naloxone / Q000627:therapeutic use*; D009292:Narcotic Antagonists / Q000627:therapeutic use
chemical_list: D000959:Antihypertensive Agents; D009292:Narcotic Antagonists; D016316:Guanfacine; D009270:Naloxone