title: Genome-wide association study identifies eight new susceptibility loci for atopic dermatitis in the Japanese population.
abstract: Atopic dermatitis is a common inflammatory skin disease caused by interaction of genetic and environmental factors. On the basis of data from a genome-wide association study (GWAS) and a validation study comprising a total of 3,328 subjects with atopic dermatitis and 14,992 controls in the Japanese population, we report here 8 new susceptibility loci: IL1RL1-IL18R1-IL18RAP (P(combined) = 8.36 × 10(-18)), the major histocompatibility complex (MHC) region (P = 8.38 × 10(-20)), OR10A3-NLRP10 (P = 1.54 × 10(-22)), GLB1 (P = 2.77 × 10(-16)), CCDC80 (P = 1.56 × 10(-19)), CARD11 (P = 7.83 × 10(-9)), ZNF365 (P = 5.85 × 10(-20)) and CYP24A1-PFDN4 (P = 1.65 × 10(-8)). We also replicated the associations of the FLG, C11orf30, TMEM232-SLC25A46, TNFRSF6B-ZGPAT, OVOL1, ACTL9 and KIF3A-IL13 loci that were previously reported in GWAS of European and Chinese individuals and a meta-analysis of GWAS for atopic dermatitis. These findings advance the understanding of the genetic basis of atopic dermatitis.
authors.affiliation: Laboratory for Respiratory Diseases, Center for Genomic Medicine, RIKEN, Yokohama, Japan.
authors.forename: Tomomitsu
authors.initials: T
authors.lastname: Hirota
authors.forename: Atsushi
authors.initials: A
authors.lastname: Takahashi
authors.forename: Michiaki
authors.initials: M
authors.lastname: Kubo
authors.forename: Tatsuhiko
authors.initials: T
authors.lastname: Tsunoda
authors.forename: Kaori
authors.initials: K
authors.lastname: Tomita
authors.forename: Masafumi
authors.initials: M
authors.lastname: Sakashita
authors.forename: Takechiyo
authors.initials: T
authors.lastname: Yamada
authors.forename: Shigeharu
authors.initials: S
authors.lastname: Fujieda
authors.forename: Shota
authors.initials: S
authors.lastname: Tanaka
authors.forename: Satoru
authors.initials: S
authors.lastname: Doi
authors.forename: Akihiko
authors.initials: A
authors.lastname: Miyatake
authors.forename: Tadao
authors.initials: T
authors.lastname: Enomoto
authors.forename: Chiharu
authors.initials: C
authors.lastname: Nishiyama
authors.forename: Nobuhiro
authors.initials: N
authors.lastname: Nakano
authors.forename: Keiko
authors.initials: K
authors.lastname: Maeda
authors.forename: Ko
authors.initials: K
authors.lastname: Okumura
authors.forename: Hideoki
authors.initials: H
authors.lastname: Ogawa
authors.forename: Shigaku
authors.initials: S
authors.lastname: Ikeda
authors.forename: Emiko
authors.initials: E
authors.lastname: Noguchi
authors.forename: Tohru
authors.initials: T
authors.lastname: Sakamoto
authors.forename: Nobuyuki
authors.initials: N
authors.lastname: Hizawa
authors.forename: Koji
authors.initials: K
authors.lastname: Ebe
authors.forename: Hidehisa
authors.initials: H
authors.lastname: Saeki
authors.forename: Takashi
authors.initials: T
authors.lastname: Sasaki
authors.forename: Tamotsu
authors.initials: T
authors.lastname: Ebihara
authors.forename: Masayuki
authors.initials: M
authors.lastname: Amagai
authors.forename: Satoshi
authors.initials: S
authors.lastname: Takeuchi
authors.forename: Masutaka
authors.initials: M
authors.lastname: Furue
authors.forename: Yusuke
authors.initials: Y
authors.lastname: Nakamura
authors.forename: Mayumi
authors.initials: M
authors.lastname: Tamari
mesh_terms: D044466:Asian People / Q000235:genetics; D003876:Dermatitis, Atopic / Q000235:genetics*; D000091344:Filaggrin Proteins; D056426:Genetic Loci; D020022:Genetic Predisposition to Disease; D055106:Genome-Wide Association Study; D006801:Humans; D020641:Polymorphism, Single Nucleotide