title: Is US-guided core needle biopsy (CNB) enough in probably benign nodules with interval growth?
abstract: OBJECTIVE
  To investigate whether ultrasound-guided 14-gauge core needle biopsy (US-CNB) is efficient in the diagnosis of probably benign lesions showing interval growth on follow-up US.
  
  
  METHODS
  From March 2008 to August 2009, 116 breast lesions in 113 women (mean age: 41.2 years, range: 19 - 63 years) which were initially assessed as category 3 showing interval growth on follow-up US underwent US-CNB, and subsequent US-guided vacuum-assisted excision, surgical excision or follow-up US for at least 12 months. Diagnostic performances of US-CNB were evaluated with histopathologic results and follow-up US as standard reference. Clinical features of the patient and lesions characteristics including follow-up interval (I), the most increased diameter (D), D per I, increased volume (%V) and %V per I were calculated and compared.
  
  
  RESULTS
  Of the 116 lesions, 4 lesions were diagnosed as malignancy and 112 as benign on final pathology. Malignancy rate of probably benign lesions showing interval growth was 3.4 % (4/116). Incorrect biopsy rate was 0.9 % (1/116). Palpability or newly developed suspicious US features were more associated with malignancy, 75.0 to 13.4 % and 50.0 to 25.9 %, respectively, but without significance (p = 0.063 and 0.290). Significant differences were seen in average rank when comparing between benign and malignancy in D, %V, D per follow-up interval (I), and %V/I (p = 0.037, 0.017, 0.043 and 0.009, respectively).
  
  
  CONCLUSIONS
  US-CNB is an efficient diagnostic method for probably benign lesions showing interval growth, with discordant biopsy rate of 0.9 %.
authors.affiliation: Department of Radiology, CHA Bundang Medical Center, CHA University, School of Medicine.
authors.forename: J H
authors.initials: JH
authors.lastname: Yoon
authors.affiliation: Department of Radiology, Research Institute of Radiological Science, Yonsei University, College of Medicine.
authors.forename: E-K
authors.initials: EK
authors.lastname: Kim
authors.affiliation: Department of Radiology, Research Institute of Radiological Science, Yonsei University, College of Medicine.
authors.forename: J Y
authors.initials: JY
authors.lastname: Kwak
authors.affiliation: Department of Radiology, Research Institute of Radiological Science, Yonsei University, College of Medicine.
authors.forename: H J
authors.initials: HJ
authors.lastname: Moon
authors.affiliation: Department of Radiology, Research Institute of Radiological Science, Yonsei University, College of Medicine.
authors.forename: M J
authors.initials: MJ
authors.lastname: Kim
mesh_terms: D000328:Adult; D001707:Biopsy, Needle / Q000379:methods*; D001940:Breast / Q000473:pathology; D001943:Breast Neoplasms / Q000473:pathology* / Q000601:surgery; D018270:Carcinoma, Ductal, Breast / Q000473:pathology / Q000601:surgery; D003937:Diagnosis, Differential; D005260:Female; D018226:Fibroadenoma / Q000473:pathology / Q000601:surgery; D005348:Fibrocystic Breast Disease / Q000473:pathology* / Q000601:surgery; D006801:Humans; D008875:Middle Aged; D003557:Phyllodes Tumor / Q000473:pathology / Q000601:surgery; D012189:Retrospective Studies; D018084:Ultrasonography, Interventional / Q000379:methods*; D016217:Ultrasonography, Mammary / Q000379:methods*; D014618:Vacuum; D055815:Young Adult