title: JAK Kinases in Health and Disease: An Update.
abstract: Janus kinases (Jaks) are critical signaling elements for a large subset of cytokines. As a consequence they play pivotal roles in the patho-physiology of many diseases including neoplastic and autoimmune diseases. Small molecule Jak inhibitors as therapeutic agents have become a reality and the palette of such inhibitors will likely expand. This review will summarize our current knowledge on these key enzymes and their associated pharmaceutical inhibitors.
authors.affiliation: Molecular Immunology and Inflammation Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA.
authors.forename: Arian
authors.initials: A
authors.lastname: Laurence
authors.forename: Marko
authors.initials: M
authors.lastname: Pesu
authors.forename: Olli
authors.initials: O
authors.lastname: Silvennoinen
authors.forename: John
authors.initials: J
authors.lastname: O'Shea