title: Response to comment on "the geometric structure of the brain fiber pathways".
abstract: In response to Catani et al., we show that corticospinal pathways adhere via sharp turns to two local grid orientations; that our studies have three times the diffusion resolution of those compared; and that the noted technical concerns, including crossing angles, do not challenge the evidence of mathematically specific geometric structure. Thus, the geometric thesis gives the best account of the available evidence.
authors.affiliation: Department of Radiology, Massachusetts General Hospital, Harvard Medical School and the Martinos Center for Biomedical Imaging, Building 129 13th Street, 2nd floor, Charlestown, MA 02129, USA. van@nmr.mgh.harvard.edu
authors.forename: Van J
authors.initials: VJ
authors.lastname: Wedeen
authors.forename: Douglas L
authors.initials: DL
authors.lastname: Rosene
authors.forename: Ruopeng
authors.initials: R
authors.lastname: Wang
authors.forename: Guangping
authors.initials: G
authors.lastname: Dai
authors.forename: Farzad
authors.initials: F
authors.lastname: Mortazavi
authors.forename: Patric
authors.initials: P
authors.lastname: Hagmann
authors.forename: Jon H
authors.initials: JH
authors.lastname: Kaas
authors.forename: Wen-Yih I
authors.initials: WY
authors.lastname: Tseng
mesh_terms: D000818:Animals; D002540:Cerebral Cortex / Q000033:anatomy & histology*; D006801:Humans; D009412:Nerve Fibers; D009434:Neural Pathways / Q000033:anatomy & histology*