title: 99mTc-Anti-TNF-α scintigraphy: a new perspective within different methods in the diagnostic approach of active Graves ophthalmopathy.
abstract: Different imaging methods applied in the evaluation of a patient with unilateral active Graves ophthalmopathy (GO) are shown in the present paper. 99mTc-Anti-TNF-α scintigraphy is proposed as a promising method, not yet described, for the diagnosis of active ocular disease. It consists of labeling a human monoclonal antibody directed against TNF-α molecule (adalimumab) with technetium (99mTc). The method is based on the demonstration of TNF-α as one of the cytokines enrolled in the initial active phase of GO development. The method may give the perspective to link diagnosis and therapy, including new target-based modalities.
authors.affiliation: Departamento de Radiologia, Faculdade de Medicina, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil.
authors.forename: Flávia Paiva Proença Lobo
authors.initials: FP
authors.lastname: Lopes
authors.forename: Sergio Augusto Lopes
authors.initials: SA
authors.lastname: de Souza
authors.forename: Patrícia de Fátima
authors.initials: Pde F
authors.lastname: Dos Santos Teixeira
authors.forename: Elisa Dos Santos
authors.initials: Edos S
authors.lastname: Rebelo Pinho
authors.forename: Lea Mirian Barbosa
authors.initials: LM
authors.lastname: da Fonseca
authors.forename: Mario
authors.initials: M
authors.lastname: Vaisman
authors.forename: Bianca
authors.initials: B
authors.lastname: Gutfilen
mesh_terms: D000911:Antibodies, Monoclonal; D049970:Graves Ophthalmopathy / Q000000981:diagnostic imaging*; D006801:Humans; D008279:Magnetic Resonance Imaging; D015282:Octreotide / Q000031:analogs & derivatives; D015609:Organotechnetium Compounds; D013667:Technetium; D015899:Tomography, Emission-Computed, Single-Photon; D014057:Tomography, X-Ray Computed; D014409:Tumor Necrosis Factor-alpha / Q000276:immunology*
chemical_list: C493098:99mTc-octreotide; D000911:Antibodies, Monoclonal; D015609:Organotechnetium Compounds; D014409:Tumor Necrosis Factor-alpha; D013667:Technetium; D015282:Octreotide