title: Syn-selective Kobayashi aldol reaction using the E,E-vinylketene silyl N,O-acetal.
abstract: The Kobayashi aldol reaction is one of the most powerful methods to synthesize the polyketide skeleton and has been applied to the total synthesis of natural products. This methodology has been used to construct anti-aldol products, and only a few precedents on the syn-selective Kobayashi aldol reaction are known. A syn-selective Kobayashi aldol reaction by using the E,E-vinylketene silyl N,O-acetal and an excess amount of Lewis acid is presented.
authors.affiliation: Department of Applied Chemistry, Faculty of Advanced Science and Engineering, Waseda University, 3-4-1 Ohkubo, Tokyo 169-8555, Japan.
authors.forename: Yuki
authors.initials: Y
authors.lastname: Mukaeda
authors.forename: Takuya
authors.initials: T
authors.lastname: Kato
authors.forename: Seijiro
authors.initials: S
authors.lastname: Hosokawa