title: One-pot catalytic enantioselective synthesis of tetrahydropyridines via a nitro-Mannich/hydroamination cascade.
abstract: The highly enantioselective preparation of synthetically useful tetrahydropyridine derivatives employing a one-pot nitro-Mannich/hydroamination cascade is reported. This approach utilizes an asymmetric organocatalytic nitro-Mannich reaction followed by a gold-catalyzed alkyne hydroamination/isomerization sequence that yields the desired tetrahydropyridines in good yields and high diastereo- and enantioselectivities.
authors.affiliation: Department of Chemistry, Chemistry Research Laboratory, University of Oxford, Mansfield Road, Oxford, OX1 3TA, UK.
authors.forename: David M
authors.initials: DM
authors.lastname: Barber
authors.forename: Hitesh J
authors.initials: HJ
authors.lastname: Sanganee
authors.forename: Darren J
authors.initials: DJ
authors.lastname: Dixon
mesh_terms: D000586:Amination; D002384:Catalysis; D006865:Hydrogenation; D015394:Molecular Structure; D009574:Nitro Compounds / Q000737:chemistry*; D011725:Pyridines / Q000138:chemical synthesis*; D013237:Stereoisomerism
chemical_list: D009574:Nitro Compounds; D011725:Pyridines