title: Acute unilateral ophthalmoplegia as the presenting sign of acute myeloid leukemia in a 15-month-old girl.
abstract: Central nervous system manifestations of acute myeloid leukemia are rare at presentation. Acute cranial nerve findings on neurologic examination can be indications for brain imaging. Magnetic resonance imaging can highlight cranial nerves emerging from the brainstem, particularly if they are gadolinium-enhanced or thickened. We describe a 15-month-old girl with acute unilateral ophthalmoplegia as the presenting sign of acute myeloid leukemia. Her presentation emphasizes the importance of appropriate laboratory and radiographic evaluation in a toddler with new-onset strabismus, which may be discounted as a previously unrecognized or benign finding.
authors.affiliation: Division of Pediatric Neurology, Department of Pediatrics, University of Michigan Health System, C.S. Mott Children's Hospital, Ann Arbor, Michigan, USA.
authors.forename: Jared
authors.initials: J
authors.lastname: Mott
authors.forename: Martha D
authors.initials: MD
authors.lastname: Carlson
mesh_terms: D000208:Acute Disease; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D007223:Infant; D015470:Leukemia, Myeloid, Acute / Q000150:complications* / Q000175:diagnosis*; D009886:Ophthalmoplegia / Q000150:complications* / Q000175:diagnosis*