title: Three-dimensional retinal and choroidal capillary imaging by power Doppler optical coherence angiography with adaptive optics.
abstract: Retinal and choroidal vascular imaging is a key to the better understanding and diagnosis of eye diseases. To achieve comprehensive three-dimensional capillary imaging, we used an enhanced vascular imaging technique, so called adaptive optics optical coherence angiography (AO-OCA). AO-OCA enables in vivo high-resolution and high-contrast micro-vascular imaging by detecting Doppler frequency shifts. Using this technique, the retinal and choroidal vasculatures of healthy subjects were imaged. The results show that both intensity and Doppler power images have sufficient contrast to discriminate almost all vasculatures from the static tissue. However, the choriocapillaris, pre-arterioles, and post-venules in the Sattler layer were more contrasted by the Doppler technique. In conclusion, AO-OCA enables three-dimensional capillary imaging, and is especially useful for the detection of the choriocapillaris and choroidal capillary network.
authors.affiliation: Computational Optics Group, University of Tsukuba, Tsukuba, Japan.
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Kurokawa
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Sasaki
authors.forename: Shuichi
authors.initials: S
authors.lastname: Makita
authors.forename: Young-Joo
authors.initials: YJ
authors.lastname: Hong
authors.forename: Yoshiaki
authors.initials: Y
authors.lastname: Yasuno
mesh_terms: D000792:Angiography / Q000295:instrumentation*; D002196:Capillaries / Q000033:anatomy & histology*; D002829:Choroid / Q000098:blood supply*; D004301:Doppler Effect; D004867:Equipment Design; D019544:Equipment Failure Analysis; D005246:Feedback; D006801:Humans; D021621:Imaging, Three-Dimensional / Q000295:instrumentation*; D012171:Retinal Vessels / Q000033:anatomy & histology*; D042261:Retinoscopes; D041623:Tomography, Optical Coherence / Q000295:instrumentation*