title: Impact of in-hospital major bleeding on outcomes in acute coronary syndromes.
abstract: OBJECTIVE
  To describe the hazard of in-hospital major bleeding after acute coronary syndromes.
  
  
  RESULTS
  Long-term complications of early bleeding can extend to over 3 years beyond the index event. Nonaccess-site bleeding accounts for much of the higher risk associated with major in-hospital bleeding.
  
  
  CONCLUSIONS
  Bleeding complications after percutaneous coronary intervention are a consistent and independent predictor of adverse clinical outcomes. The majority of complications associated with major bleeding are attributable to in-hospital early bleeds. Whether the link between bleeding and increased mortality is causal has not been established. Bleeding may simply be a marker of higher comorbidity. When possible, bleeding should be avoided, and strategies such as use of risk scores, bivalirudin, vascular closure devices and radial access may decrease major bleeding. In the highest-risk patients, however, bleeding avoidance strategies may not be effective.
authors.affiliation: Zena and Michael A. Wiener Cardiovascular Institute, Mount Sinai School of Medicine, New York, New York 10029, USA.
authors.forename: Sharon S
authors.initials: SS
authors.lastname: Choi
authors.forename: Ziad
authors.initials: Z
authors.lastname: Sergie
authors.forename: Roxana
authors.initials: R
authors.lastname: Mehran
mesh_terms: D054058:Acute Coronary Syndrome / Q000150:complications* / Q000473:pathology / Q000628:therapy; D015906:Angioplasty, Balloon, Coronary / Q000009:adverse effects*; D000991:Antithrombins / Q000627:therapeutic use*; D006470:Hemorrhage / Q000209:etiology* / Q000401:mortality / Q000517:prevention & control; D006629:Hirudins; D006760:Hospitalization; D006801:Humans; D010446:Peptide Fragments / Q000627:therapeutic use*; D011994:Recombinant Proteins / Q000627:therapeutic use; D012307:Risk Factors; D016896:Treatment Outcome
chemical_list: D000991:Antithrombins; D006629:Hirudins; D010446:Peptide Fragments; D011994:Recombinant Proteins; C074619:bivalirudin