title: Neuroprotective effect of resveratrol against prenatal stress induced cognitive impairment and possible involvement of Na(+), K(+)-ATPase activity.
abstract: Resveratrol, an active ingredient of red wine extracts, has been shown to exhibit neuroprotective effects in several experimental models. Hence in the present study, the protective effects of resveratrol on cognitive deficits induced by prenatal stress were evaluated in offspring, and the possible involvement of Na(+), K(+)-ATPase in learning deficits were explored. Pregnant rats were subjected to restraint stress during early or late gestational period. Another set of rats received resveratrol during the entire gestational period along with early or late gestational stress. The study parameters included various behavioral tests like open field test and Morris water maze test. At the end of the behavioral tests (on 40th postnatal day), the offspring were sacrificed, and their brain homogenate was subjected to Na(+), K(+)-ATPase estimation. Early and late gestational stress affected spatial learning and memory and prenatal resveratrol has reversed these cognitive deficits. The Na(+), K(+)-ATPase activity in the offspring brain homogenate was reduced in the late gestational stress group; however prenatal resveratrol treatment has not affected this activity. These data suggest the neuroprotective efficacy of resveratrol against prenatal stress induced cognitive impairment. Though late gestational stress involves Na(+), K(+)-ATPase activity in rat brain homogenate, this would not be the primary cause in prenatal stress-induced cognitive dysfunction.
authors.affiliation: Department of Anatomy, Kasturba Medical College, Mangalore, Manipal University, 575 001 India.
authors.forename: Sudhanshu Sekhar
authors.initials: SS
authors.lastname: Sahu
authors.forename: Sampath
authors.initials: S
authors.lastname: Madhyastha
authors.forename: Gayathri M
authors.initials: GM
authors.lastname: Rao
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000494:pharmacology* / Q000627:therapeutic use; D001921:Brain / Q000187:drug effects / Q000378:metabolism; D003072:Cognition Disorders / Q000150:complications / Q000188:drug therapy / Q000517:prevention & control*; D004195:Disease Models, Animal; D005260:Female; D008297:Male; D018782:Maze Learning / Q000187:drug effects; D018696:Neuroprotective Agents / Q000494:pharmacology* / Q000627:therapeutic use; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects / Q000517:prevention & control*; D017208:Rats, Wistar; D012149:Restraint, Physical; D000077185:Resveratrol; D000254:Sodium-Potassium-Exchanging ATPase / Q000378:metabolism*; D013267:Stilbenes / Q000494:pharmacology* / Q000627:therapeutic use; D013315:Stress, Psychological / Q000150:complications / Q000188:drug therapy* / Q000523:psychology
chemical_list: D000975:Antioxidants; D018696:Neuroprotective Agents; D013267:Stilbenes; D000254:Sodium-Potassium-Exchanging ATPase; D000077185:Resveratrol