title: Biological activity of sedaxane---a novel broad-spectrum fungicide for seed treatment.
abstract: BACKGROUND
  Sedaxane is a new broad-spectrum seed treatment fungicide developed by Syngenta Crop Protection for control of seed- and soil-borne diseases in a broad range of crops. Its physicochemical properties and activity spectrum have been optimised for use as a seed treatment providing both local and systemic protection of the seed and roots of target crops.
  
  
  RESULTS
  Sedaxane inhibits respiration by binding to the succinate dehydrogenase complex in the fungal mitochondrium. Its activity spectrum covers seed-borne fungi such as Ustilago nuda, Tilletia caries, Monographella nivalis and Pyrenophora graminea, as well as the soil-borne fungi Rhizoctonia solani, R. cerealis and Typhula incarnata. Under greenhouse conditions, sedaxane showed high levels and consistent protection against U. nuda, P. graminea and Rhizoctonia spp. Under field conditions, efficacy against Rhizoctonia spp. resulted in increased yield compared with the untreated check. Efficacy against snow mould has been shown under very high disease pressure conditions. The combination of sedaxane plus fludioxonil against snow mould can provide resistance management for sustainable use.
  
  
  CONCLUSIONS
  The broad spectrum and high level of activity in combination with excellent crop tolerance allow the use of sedaxane as a seed treatment in a wide variety of crops. It is a potential tool for precautionary resistance management when combined with other fungicides, especially against pathogens showing a potential for resistance development, such as M. nivalis.
authors.affiliation: Syngenta AG, Crop Protection Research, Biology, Stein, Switzerland. ronald.zeun@syngenta.com
authors.forename: Ronald
authors.initials: R
authors.lastname: Zeun
authors.forename: Gabriel
authors.initials: G
authors.lastname: Scalliet
authors.forename: Michael
authors.initials: M
authors.lastname: Oostendorp
mesh_terms: D000813:Anilides / Q000494:pharmacology*; D018556:Crops, Agricultural / Q000382:microbiology*; D005659:Fungicides, Industrial / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D011720:Pyrazoles / Q000494:pharmacology*; D012232:Rhizoctonia / Q000187:drug effects; D012639:Seeds / Q000382:microbiology*; D013385:Succinate Dehydrogenase / Q000037:antagonists & inhibitors*; D014588:Ustilago / Q000187:drug effects
chemical_list: D000813:Anilides; D005659:Fungicides, Industrial; C583365:N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide; D011720:Pyrazoles; D013385:Succinate Dehydrogenase