title: A program for sustained improvement in preventing ventilator associated pneumonia in an intensive care setting.
abstract: BACKGROUND
  Ventilator-associated pneumonia (VAP) is a common infection in the intensive care unit (ICU) and associated with a high mortality.
  
  
  METHODS
  A quasi-experimental study was conducted in a medical-surgical ICU. Multiple interventions to optimize VAP prevention were performed from October 2008 to December 2010. All of these processes, including the Institute for Healthcare Improvement's (IHI) ventilator bundle plus oral decontamination with chlorhexidine and continuous aspiration of subglottic secretions (CASS), were adopted for patients undergoing mechanical ventilation.
  
  
  RESULTS
  We evaluated a total of 21,984 patient-days, and a total of 6,052 ventilator-days (ventilator utilization rate of 0.27). We found VAP rates of 1.3 and 2.0 per 1,000 ventilator days respectively in 2009 and 2010, achieving zero incidence of VAP several times during 12 months, whenever VAP bundle compliance was over 90%.
  
  
  CONCLUSIONS
  These results suggest that it is possible to reduce VAP rates to near zero and sustain these rates, but it requires a complex process involving multiple performance measures and interventions that must be permanently monitored.
authors.affiliation: Intensive Care Unit, Hospital Israelita Albert Einstein, Av, Albert Einstein, 627/701 - 5º Andar - Bloco B, São Paulo, CEP 05651-901, Brazil. raquel_case@eintein.br
authors.forename: Raquel A
authors.initials: RA
authors.lastname: Caserta
authors.forename: Alexandre R
authors.initials: AR
authors.lastname: Marra
authors.forename: Marcelino S
authors.initials: MS
authors.lastname: Durão
authors.forename: Cláudia Vallone
authors.initials: CV
authors.lastname: Silva
authors.forename: Oscar Fernando
authors.initials: OF
authors.lastname: Pavao dos Santos
authors.forename: Henrique Sutton de Sousa
authors.initials: HS
authors.lastname: Neves
authors.forename: Michael B
authors.initials: MB
authors.lastname: Edmond
authors.forename: Karina Tavares
authors.initials: KT
authors.lastname: Timenetsky
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006801:Humans; D017053:Infection Control / Q000379:methods*; D007362:Intensive Care Units; D008297:Male; D008875:Middle Aged; D053717:Pneumonia, Ventilator-Associated / Q000517:prevention & control*