title: Bex2 regulates cell proliferation and apoptosis in malignant glioma cells via the c-Jun NH2-terminal kinase pathway.
abstract: The function of Bex2, a member of the Brain Expressed X-linked gene family, in glioma is controversial and its mechanism is largely unknown. We report here that Bex2 regulates cell proliferation and apoptosis in malignant glioma cells via the c-Jun NH2-terminal kinase (JNK) pathway. The expression level of Bex2 is markedly increased in glioma tissues. We observed that Bex2 over-expression promotes cell proliferation, while down-regulation of Bex2 inhibits cell growth. Furthermore, Bex2 down-regulation promotes cell apoptosis and activates the JNK pathway; these effects were abolished by administration of the JNK specific inhibitor, SP600125. Thus, Bex2 may be an important player during the development of glioma.
authors.affiliation: Department of Neurosurgery, Affiliated Hospital of Xuzhou Medical College, Xuzhou, Jiangsu, China. xpzhou@xzmc.edu.cn
authors.forename: Xiuping
authors.initials: X
authors.lastname: Zhou
authors.forename: Qingming
authors.initials: Q
authors.lastname: Meng
authors.forename: Xuebin
authors.initials: X
authors.lastname: Xu
authors.forename: Tongle
authors.initials: T
authors.lastname: Zhi
authors.forename: Qiong
authors.initials: Q
authors.lastname: Shi
authors.forename: Yong
authors.initials: Y
authors.lastname: Wang
authors.forename: Rutong
authors.initials: R
authors.lastname: Yu
mesh_terms: D000873:Anthracenes / Q000494:pharmacology; D017209:Apoptosis; D045744:Cell Line, Tumor; D049109:Cell Proliferation; D015536:Down-Regulation; D005910:Glioma / Q000378:metabolism / Q000473:pathology*; D006801:Humans; D048031:JNK Mitogen-Activated Protein Kinases / Q000037:antagonists & inhibitors / Q000378:metabolism*; D009419:Nerve Tissue Proteins / Q000235:genetics / Q000378:metabolism*; D047428:Protein Kinase Inhibitors / Q000494:pharmacology; D015398:Signal Transduction
chemical_list: D000873:Anthracenes; C530662:BEX2 protein, human; D009419:Nerve Tissue Proteins; D047428:Protein Kinase Inhibitors; C432165:pyrazolanthrone; D048031:JNK Mitogen-Activated Protein Kinases