title: Hypocholesterolemic effects of low calorie structured lipids on rats and rabbits fed on normal and atherogenic diet.
abstract: The hypocholesterolemic effects of two low calorie structured lipids (SL1 and SL2) containing essential fatty acids, prepared by lipase catalysed interesterification of ethyl behenate respectively with sunflower and soybean oils were studied in rats and rabbits. The feeding experiment conducted on rats as well as rabbits, fed on normal and atherogenic diet containing 10% of SL1 and SL2 (experimental) and sunflower oil (control) indicated no adverse effects on growth and food intake. However, the structured lipids beneficially lowered serum and liver lipids, particularly cholesterol, LDL cholesterol, triglycerides and also maintains the essential fatty acid status in serum and liver. The lipid deposition observed in the arteries of rabbits fed on atherogenic diets was significantly reduced when structured lipids were included in the diet. These observations coincided with reduced levels of serum cholesterol particularly LDL cholesterol observed in experimental groups. Therefore the structured lipids, designed to have low calorific value also beneficially lower serum lipids and lipid deposition in animals fed on atherogenic diets.
authors.affiliation: Centre for Lipid Research, Indian Institute of Chemical Technology, Hyderabad, India.
authors.forename: Sanjit
authors.initials: S
authors.lastname: Kanjilal
authors.forename: Shiva Shanker
authors.initials: SS
authors.lastname: Kaki
authors.forename: Bhamidipati V S K
authors.initials: BV
authors.lastname: Rao
authors.forename: Dhavamani
authors.initials: D
authors.lastname: Sugasini
authors.forename: Yalagala Poornachandra
authors.initials: YP
authors.lastname: Rao
authors.forename: Rachapudi B N
authors.initials: RB
authors.lastname: Prasad
authors.forename: Belur R
authors.initials: BR
authors.lastname: Lokesh
mesh_terms: D000818:Animals; D000924:Anticholesteremic Agents / Q000737:chemistry / Q000378:metabolism*; D002784:Cholesterol / Q000097:blood; D004036:Diet, Atherogenic / Q000009:adverse effects*; D004041:Dietary Fats / Q000032:analysis / Q000378:metabolism*; D006801:Humans; D006937:Hypercholesterolemia / Q000209:etiology / Q000378:metabolism* / Q000517:prevention & control; D050356:Lipid Metabolism; D008297:Male; D010938:Plant Oils / Q000737:chemistry / Q000378:metabolism*; D011817:Rabbits; D051381:Rats; D017208:Rats, Wistar; D013024:Soybean Oil / Q000737:chemistry / Q000378:metabolism*; D000074242:Sunflower Oil
chemical_list: D000924:Anticholesteremic Agents; D004041:Dietary Fats; D010938:Plant Oils; D000074242:Sunflower Oil; D013024:Soybean Oil; D002784:Cholesterol