title: Three new sesquiterpenes with cytotoxic activity from Dobinea delavayi.
abstract: Three new sesquiterpenes dobinins A-C (1-3), together with five known compounds, were isolated from the root of Dobinea delavayi. The structures of the three new compounds were determined on the basis of spectroscopic analysis including 1D-, 2D-NMR and MS techniques as well as by comparison of the spectral data with those of analogous compounds reported in the literatures. Compounds 1-3 were screened for antitumor activity in vitro and exhibited definite cytotoxic activity against the human tumor cell line HL-60 with IC50 levels of 8.0 × 10-5, 4.7 × 10-5, and 5.1 × 10-5 M, respectively.
authors.affiliation: State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, The Chinese Academy of Sciences, Kunming, P R China.
authors.forename: Zhong-Quan
authors.initials: ZQ
authors.lastname: Cheng
authors.forename: Dan
authors.initials: D
authors.lastname: Yang
authors.forename: Qing-Yun
authors.initials: QY
authors.lastname: Ma
authors.forename: Hao-Fu
authors.initials: HF
authors.lastname: Dai
authors.forename: Sheng-Zhuo
authors.initials: SZ
authors.lastname: Huang
authors.forename: Xiang-Hui
authors.initials: XH
authors.lastname: Yi
authors.forename: Jun
authors.initials: J
authors.lastname: Zhou
authors.forename: You-Xing
authors.initials: YX
authors.lastname: Zhao
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D003603:Cytotoxins / Q000302:isolation & purification; D018922:HL-60 Cells; D006801:Humans; D020128:Inhibitory Concentration 50; D007938:Leukemia / Q000188:drug therapy*; D008175:Lung Neoplasms / Q000188:drug therapy*; D015394:Molecular Structure; D018517:Plant Roots / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry; D029631:Sapindaceae / Q000737:chemistry*; D012717:Sesquiterpenes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D014407:Tumor Cells, Cultured / Q000187:drug effects
chemical_list: C580918:3-angeloyloxy-4-acetoxyeudesm-7(11)-en-8,12-olide; C580917:3-angeloyloxy-4-hydroxyeudesm-7(11)-en-8,12-olide; C580919:3-angeloyloxy-4-hydroxyleudesm-7(11),8(9)-dien-8,12-olide; D000972:Antineoplastic Agents, Phytogenic; D003603:Cytotoxins; D012717:Sesquiterpenes