title: Clinical profile of concurrent dengue fever and Plasmodium vivax malaria in the Brazilian Amazon: case series of 11 hospitalized patients.
abstract: Malaria and dengue fever are the most prevalent vector-borne diseases worldwide. This study aims to describe the clinical profile of patients with molecular diagnosis of concurrent malaria and dengue fever in a tropical-endemic area. Eleven patients with concurrent dengue virus (DENV) and Plasmodium vivax infection are reported. Similar frequencies of DENV-2, DENV-3, and DENV-4 were found, including DENV-3/DENV-4 co-infection. In eight patients, the World Health Organization (WHO) criteria for severe malaria could be fulfilled (jaundice being the most common). Only one patient met severe dengue criteria, but warning signs were present in 10. Syndromic surveillance systems must be ready to identify this condition to avoid misinterpretation of severity attributed to a single disease.
authors.affiliation: Universidade do Estado do Amazonas, Manaus, Brazil. magalhaesbelisa@gmail.com
authors.forename: Belisa M L
authors.initials: BM
authors.lastname: Magalhães
authors.forename: Márcia A A
authors.initials: MA
authors.lastname: Alexandre
authors.forename: André M
authors.initials: AM
authors.lastname: Siqueira
authors.forename: Gisely C
authors.initials: GC
authors.lastname: Melo
authors.forename: João B L
authors.initials: JB
authors.lastname: Gimaque
authors.forename: Michele S
authors.initials: MS
authors.lastname: Bastos
authors.forename: Regina M P
authors.initials: RM
authors.lastname: Figueiredo
authors.forename: Ricardo C
authors.initials: RC
authors.lastname: Carvalho
authors.forename: Michel A
authors.initials: MA
authors.lastname: Tavares
authors.forename: Felipe G
authors.initials: FG
authors.lastname: Naveca
authors.forename: Pedro
authors.initials: P
authors.lastname: Alonso
authors.forename: Quique
authors.initials: Q
authors.lastname: Bassat
authors.forename: Marcus V G
authors.initials: MV
authors.lastname: Lacerda
authors.forename: Maria P G
authors.initials: MP
authors.lastname: Mourão
mesh_terms: D000293:Adolescent; D000328:Adult; D000369:Aged, 80 and over; D001938:Brazil / Q000453:epidemiology; D060085:Coinfection / Q000453:epidemiology / Q000469:parasitology / Q000821:virology; D003715:Dengue / Q000150:complications* / Q000453:epidemiology; D003716:Dengue Virus / Q000145:classification; D005260:Female; D006801:Humans; D007297:Inpatients; D016780:Malaria, Vivax / Q000150:complications* / Q000453:epidemiology / Q000473:pathology; D008297:Male; D008875:Middle Aged; D010966:Plasmodium vivax