title: Cutting edge: regulation of intestinal inflammation and barrier function by IL-17C.
abstract: In the IL-17 family of cytokines, much is known about the sources and functions of IL-17, IL-17F, and IL-25 in the host defense against infection and in inflammatory diseases; however, the physiological function of IL-17C remains poorly understood. Using mice deficient in IL-17C, we demonstrate that this cytokine is crucial for the regulation of an acute experimental colitis elicited by dextran sulfate sodium. In this model, mice lacking IL-17C exhibited exacerbated disease that was associated with increased IL-17 expression by γδ T cells and Th17 cells. Moreover, IL-17C directly regulated the expression of the tight junction molecule occludin by colonic epithelial cells. Thus, our data suggest that IL-17C plays a critical role in maintaining mucosal barrier integrity.
authors.affiliation: Department of Immunology and Center for Inflammation and Cancer, MD Anderson Cancer Center, Houston, TX 77054, USA.
authors.forename: Joseph M
authors.initials: JM
authors.lastname: Reynolds
authors.forename: Gustavo J
authors.initials: GJ
authors.lastname: Martinez
authors.forename: Kalyan C
authors.initials: KC
authors.lastname: Nallaparaju
authors.forename: Seon Hee
authors.initials: SH
authors.lastname: Chang
authors.forename: Yi-Hong
authors.initials: YH
authors.lastname: Wang
authors.forename: Chen
authors.initials: C
authors.lastname: Dong
mesh_terms: D000818:Animals; D002460:Cell Line; D003092:Colitis / Q000235:genetics / Q000276:immunology* / Q000473:pathology*; D003106:Colon / Q000166:cytology / Q000276:immunology / Q000473:pathology; D016264:Dextran Sulfate / Q000633:toxicity; D004195:Disease Models, Animal; D004848:Epithelium / Q000276:immunology / Q000378:metabolism / Q000473:pathology; D020022:Genetic Predisposition to Disease; D018836:Inflammation Mediators / Q000378:metabolism / Q000502:physiology*; D020381:Interleukin-17 / Q000096:biosynthesis / Q000172:deficiency / Q000502:physiology*; D007413:Intestinal Mucosa / Q000276:immunology* / Q000378:metabolism / Q000473:pathology*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D018345:Mice, Knockout
chemical_list: C515930:Il17c protein, mouse; D018836:Inflammation Mediators; D020381:Interleukin-17; D016264:Dextran Sulfate