title: Tandem carbon-carbon bond insertion and intramolecular aldol reaction of benzyne with aroylacetones: novel formation of 4,4'-disubstituted 1,1'-binaphthols.
abstract: An efficient route to 4-aryl-2-naphthols from arynes and aroylacetones was developed by carbon-carbon bond insertion followed by an intramolecular aldol reaction and dehydration. Benzyne derived from 2-(trimethylsilyl)phenyl triflate reacted with benzoylacetones in refluxing acetonitrile to give 4-aryl-2-naphthols and 3-aryl-1-naphthols.
authors.affiliation: Department of Chemistry, Faculty of Science, Fukuoka University, Fukuoka 814-0180, Japan. kokuma@fukuoka-u.ac.jp
authors.forename: Kentaro
authors.initials: K
authors.lastname: Okuma
authors.forename: Ryoichi
authors.initials: R
authors.lastname: Itoyama
authors.forename: Ayumi
authors.initials: A
authors.lastname: Sou
authors.forename: Noriyoshi
authors.initials: N
authors.lastname: Nagahora
authors.forename: Kosei
authors.initials: K
authors.lastname: Shioj