title: Oral chloral hydrate vs. intranasal midazolam for sedation during computerized tomography.
abstract: We conducted this single blind randomized clinical trial to compare the efficacy and safety of oral chloral hydrate and intranasal midazolam for induction of sedation for computerized tomography scan of brain in children. Participants aged 1-10 years (n=60) were randomized to receive 100 mg/kg chloral hydrate orally with intra nasal normal saline OR intranasal midazolam 0.2 mg/kg with oral normal saline. Adequate sedation (Ramsay sedation score of four) was obtained and CT scan completed successfully in 76.7% of chloral hydrate group and in 40% of midazolam group (P=0.004). No significant difference was seen for side effects frequency between the two drugs (10% in chloral hydrate, 3.3% in midazolam group; P=0.34). We conclude that oral chloral hydrate can be considered as a safe and effective drug for sedation in children undergoing CT scan of brain.
authors.affiliation: Department of Pediatrics, Research Center of Pain, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
authors.forename: Razieh
authors.initials: R
authors.lastname: Fallah
authors.forename: Mohammad Hosein Ataee
authors.initials: MH
authors.lastname: Nakhaei
authors.forename: Shekofah
authors.initials: S
authors.lastname: Behdad
authors.forename: Reza Nafisi
authors.initials: RN
authors.lastname: Moghaddam
authors.forename: Ali
authors.initials: A
authors.lastname: Shamszadeh
mesh_terms: D000281:Administration, Intranasal; D000284:Administration, Oral; D002675:Child, Preschool; D002697:Chloral Hydrate / Q000008:administration & dosage* / Q000009:adverse effects; D016292:Procedural Sedation / Q000379:methods*; D005260:Female; D006801:Humans; D006993:Hypnotics and Sedatives / Q000008:administration & dosage* / Q000009:adverse effects; D007223:Infant; D008297:Male; D008874:Midazolam / Q000008:administration & dosage* / Q000009:adverse effects; D059906:Neuroimaging; D016037:Single-Blind Method; D014057:Tomography, X-Ray Computed / Q000379:methods*
chemical_list: D006993:Hypnotics and Sedatives; D002697:Chloral Hydrate; D008874:Midazolam