title: [Efficacy of surgical treatment of medullary thyroid carcinoma in patients with regional and distant metastases].
abstract: Results of surgical treatment of 93 primary patients with medullary thyroid carcinoma within 1995-2009 years, including 26 (28%) - with hereditary disease (MEN2 syndrome) were analyzed. The best long-term results were observed in group of noninvasive tumor without metastases at the time of operation (39% - clinical and biochemical recovery, 32% - clinical remission). No one patient with extrathyroid tumor invasion and regional/distant metastases has completely recovered. Hereditary forms of disease are more aggressiveness in comparison with sporadic carcinomas with higher rate of distant metastases (31 and 21%) and worse survival. In sporadic group 3 (6%) patients and in hereditary group - 4 (12%) died from progression of distant metastases within 8-15 years after primary operation. Complete recovery was seen only after radical primary operations. Repeated surgery was palliative. Implementation of calcitonine screening and genetic testing for Ret-protooncogene mutation is an important task for Ukraine medicine to improve results of medullary carcinoma treatment.
authors.forename: O S
authors.initials: OS
authors.lastname: Larin
authors.forename: S M
authors.initials: SM
authors.lastname: Cheren'ko
authors.forename: O P
authors.initials: OP
authors.lastname: Nechaĭ
authors.forename: M S
authors.initials: MS
authors.lastname: Cheren'ko
mesh_terms: D000328:Adult; D017668:Age of Onset; D000368:Aged; D018276:Carcinoma, Medullary / Q000235:genetics / Q000401:mortality / Q000556:secondary* / Q000601:surgery*; D015897:Comorbidity; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D008297:Male; D008875:Middle Aged; D018813:Multiple Endocrine Neoplasia Type 2a / Q000235:genetics / Q000401:mortality; D015996:Survival Rate; D013964:Thyroid Neoplasms / Q000235:genetics / Q000401:mortality* / Q000601:surgery*; D016896:Treatment Outcome