title: [Experimental study on anaphylactoid reactions of guinea pig induced by danshen injection and its components].
abstract: OBJECTIVE
  To compare the anaphylactoid effect of Danshen injection and its components on guinea pig.
  
  
  METHODS
  Applying active systemic anaphylaxis (ASA) tests, the corresponding experimental injections were administrated to guinea pigs to sensitized, and allergen with double doses was injected to stimulate in the 11 days after the last sensitized. The anaphylaxis situation of guinea pigs was observed.
  
  
  RESULTS
  Danshen injection and its components are suspicion on guinea pigs, while negative reaction was observed on guinea pigs which injected by the liquid excipients of Danshen injection.
  
  
  CONCLUSIONS
  Danshen injection using the ultrafiltration method still have some antigenic impurities which cannot be removed completely, and this may be one of the reasons for anaphylactic reaction.
authors.affiliation: Experimental Research Center of Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing 100091, China. sunzhuyang@163.com
authors.forename: Weifeng
authors.initials: W
authors.lastname: Yang
authors.forename: Xuezhao
authors.initials: X
authors.lastname: Yu
authors.forename: Ping
authors.initials: P
authors.lastname: He
authors.forename: Wei
authors.initials: W
authors.lastname: Hao
authors.forename: Yikui
authors.initials: Y
authors.lastname: Li
mesh_terms: D000707:Anaphylaxis / Q000139:chemically induced*; D000818:Animals; D004365:Drugs, Chinese Herbal / Q000633:toxicity*; D005260:Female; D006168:Guinea Pigs; D007267:Injections / Q000379:methods; D008297:Male; D010618:Phenanthrolines / Q000633:toxicity*; D027561:Salvia miltiorrhiza / Q000737:chemistry / Q000633:toxicity*
chemical_list: D004365:Drugs, Chinese Herbal; D010618:Phenanthrolines; C028972:dan-shen root extract