title: A retrospective analysis of amniocenteses performed for advanced maternal age and various other indications in Turkish women.
abstract: OBJECTIVE
  Prenatal cytogenetic diagnostic methods for the diagnosis of fetal chromosomal anomalies have been used reliably over the last 40 years. Advanced maternal age has become a basic indication for amniocentesis.
  
  
  METHODS
  We examined the results of the chromosome analyses of 3485 women that had amniocentesis for any reason during their antenatal care in our perinatology clinic in 2007-2009. Amniocentesis was performed for advanced maternal age in 1456 women (41.8%) and for other reasons in the remaining 2029 women (58.2%). Chromosomal anomalies were examined numerically and structurally.
  
  
  RESULTS
  When the amniocentesis results of the patients were reviewed as numerically normal or abnormal; 40 (2.7%) of 1456 amniocentesis procedures performed for advanced maternal age, 5 (0.9%) of 531 procedures performed for an increased double-test risk and 14 (1.3%) of 1095 procedures performed for an increased triple test risk were found to have chromosomal aneuploidy.
  
  
  CONCLUSIONS
  Maternal age is still the most prevalent indication for genetic amniocentesis other than positive prenatal screening tests. Among women with advanced maternal age, prenatal ultrasonography for soft markers of chromosomal aneuploidy accompanied with maternal serum biochemical screening tests should be evaluated during the decision making process of genetic amniocentesis.
authors.affiliation: Department of High Risk Pregnancy, Zekai Tahir Burak Women's Health and Research Hospital, Ankara, Turkey.
authors.forename: Nuri
authors.initials: N
authors.lastname: Danisman
authors.forename: Serkan
authors.initials: S
authors.lastname: Kahyaoglu
authors.forename: Sevki
authors.initials: S
authors.lastname: Celen
authors.forename: Inci
authors.initials: I
authors.lastname: Kahyaoglu
authors.forename: Zuhal
authors.initials: Z
authors.lastname: Candemir
authors.forename: Ahmet
authors.initials: A
authors.lastname: Yesilyurt
authors.forename: Esra Sukran
authors.initials: ES
authors.lastname: Cakar
mesh_terms: D059786:Abnormal Karyotype / Q000706:statistics & numerical data; D000328:Adult; D000649:Amniocentesis / Q000379:methods / Q000706:statistics & numerical data*; D004314:Down Syndrome / Q000175:diagnosis / Q000453:epidemiology / Q000235:genetics; D005260:Female; D006801:Humans; D008423:Maternal Age; D011247:Pregnancy; D011248:Pregnancy Complications / Q000175:diagnosis* / Q000453:epidemiology / Q000209:etiology; D017584:Reproductive History; D012189:Retrospective Studies; D012307:Risk Factors; D014421:Turkey / Q000453:epidemiology