title: MR characterization of focal nodular hyperplasia: gadoxetic acid versus superparamagnetic iron oxide imaging.
abstract: OBJECTIVE
  We evaluated the diagnostic efficacy of gadoxetic acid- and superparamagnetic iron oxide (SPIO)-enhanced magnetic resonance (MR) imaging for focal nodular hyperplasia (FNH).
  
  
  METHODS
  We retrospectively evaluated 11 patients with 11 FNHs. Both gadoxetic acid- and SPIO-enhanced MR imaging were performed. A 3-dimensional (3D) volumetric interpolated breath-hold examination was used with the gadoxetic acid dynamic study. SPIO-enhanced MR imaging included T₂- and T₂*-weighted images. We quantitatively and qualitatively compared lesion-specific enhancement of both contrast media.
  
  
  RESULTS
  The mean signal-to-noise (S/N) ratio of the FNH lesions differed significantly on pre- and postenhanced imaging of each contrast medium (P<0.05); mean contrast-to-noise (C/N) ratio did not (P>0.05). All observers described all lesions as hyperintense in the arterial phase on gadoxetic acid-enhanced MR imaging and observed the presence of central scar, fibrous septa, and rim most clearly in gadoxetic acid-enhanced hepatobiliary phase images.
  
  
  CONCLUSIONS
  Gadoxetic acid-enhanced MR imaging was more useful than SPIO-enhanced MR imaging in characterizing FNH.
authors.affiliation: Department of Radiology, Tokyo Medical University, Tokyo, Japan. saito-k@tokyo-med.ac.jp
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Saito
authors.forename: Nobutaka
authors.initials: N
authors.lastname: Yoshimura
authors.forename: Toru
authors.initials: T
authors.lastname: Saguchi
authors.forename: Jinho
authors.initials: J
authors.lastname: Park
authors.forename: Katsutoshi
authors.initials: K
authors.lastname: Sugimoto
authors.forename: Soichi
authors.initials: S
authors.lastname: Akata
authors.forename: Fuminori
authors.initials: F
authors.lastname: Moriyasu
authors.forename: Koichi
authors.initials: K
authors.lastname: Tokuuye
mesh_terms: D000328:Adult; D000368:Aged; D003287:Contrast Media; D003911:Dextrans; D005260:Female; D020518:Focal Nodular Hyperplasia / Q000473:pathology*; D019786:Gadolinium DTPA; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D058185:Magnetite Nanoparticles; D008297:Male; D008875:Middle Aged; D015203:Reproducibility of Results; D012189:Retrospective Studies; D012680:Sensitivity and Specificity
chemical_list: D003287:Contrast Media; D003911:Dextrans; D058185:Magnetite Nanoparticles; C097921:ferumoxtran-10; C073590:gadolinium ethoxybenzyl DTPA; D019786:Gadolinium DTPA