title: Sex matching plays a role in outcome of kidney transplant.
abstract: OBJECTIVE
  The effect of sex matching between donors and recipients was studied in 135 kidney transplant operations performed in our center between December 1998 and December 2007.
  
  
  METHODS
  Patients were divided into 4 groups: group 1 (63 patients, male donor-male recipient), group 2 (25 patients, male donor-female recipient), group 3 (37 patients, female donor-male recipient), and group 4 (10 patients, female donor-female recipient). Except for donor age, recipient body mass index and donor-recipient HLA AB-DR matching, recipient, and donor demographics, and the immunosuppression were comparable in all groups.
  
  
  RESULTS
  Acute rejection and the need for antithymocyte globulin Fresenius rescue therapy were comparable between the 4 donor-recipient combinations. Excellent 1-year actuarial patient and graft survival, comparable hospital stay, and incidence of delayed graft and slow graft function were comparable between the 4 groups. One death occurred, each, in groups 1 and 2; posttransplant complications being comparable. While 1-year graft survival (death censored and uncensored) were comparable, 1-year graft function (serum creatinine) showed that the worst graft function was seen in group 3 (female-to-male). Significant differences between the 4 patient groups also were seen in pretransplant and posttransplant hemoglobin levels as well as in posttransplant arterial hypertension and high-density lipoprotein cholesterol blood levels. Other metabolic indices were generally comparable between the 4 patient groups.
  
  
  CONCLUSIONS
  These results revealed that sex mismatching (group 2, male donor to female recipient) had the best 1-year graft function but the same 1-year patient and graft survival.
authors.affiliation: Transplantation Unit, Sacré-Coeur Hospital, Baabda, Lebanon.
authors.forename: Maroun M
authors.initials: MM
authors.lastname: Abou-Jaoude
authors.forename: Walid J
authors.initials: WJ
authors.lastname: Abou-Jaoude
authors.forename: Wassim Y
authors.initials: WY
authors.lastname: Almawi
mesh_terms: D000206:Actuarial Analysis; D000208:Acute Disease; D000328:Adult; D051799:Delayed Graft Function / Q000401:mortality*; D005260:Female; D006084:Graft Rejection / Q000188:drug therapy / Q000401:mortality*; D006650:Histocompatibility Testing / Q000379:methods*; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D015994:Incidence; D016030:Kidney Transplantation / Q000401:mortality*; D007902:Length of Stay / Q000706:statistics & numerical data; D008297:Male; D008659:Metabolic Diseases / Q000401:mortality; D008875:Middle Aged; D055031:Primary Graft Dysfunction / Q000401:mortality*; D012189:Retrospective Studies; D017678:Sex Distribution; D014019:Tissue Donors / Q000706:statistics & numerical data*; D055815:Young Adult
chemical_list: D007166:Immunosuppressive Agents