title: Similarity analysis, synthesis, and bioassay of antibacterial cyclic peptidomimetics.
abstract: The chemical similarity of antibacterial cyclic peptides and peptidomimetics was studied in order to identify new promising cyclic scaffolds. A large descriptor space coupled with cluster analysis was employed to digitize known antibacterial structures and to gauge the potential of new peptidomimetic macrocycles, which were conveniently synthesized by acylbenzotriazole methodology. Some of the synthesized compounds were tested against an array of microorganisms and showed antibacterial activity against Bordetella bronchistepica, Micrococcus luteus, and Salmonella typhimurium.
authors.affiliation: Center for Heterocyclic Compounds, Department of Chemistry, University of Florida, Gainesville, FL 32611-7200, USA.
authors.forename: Workalemahu M
authors.initials: WM
authors.lastname: Berhanu
authors.forename: Mohamed A
authors.initials: MA
authors.lastname: Ibrahim
authors.forename: Girinath G
authors.initials: GG
authors.lastname: Pillai
authors.forename: Alexander A
authors.initials: AA
authors.lastname: Oliferenko
authors.forename: Levan
authors.initials: L
authors.lastname: Khelashvili
authors.forename: Farukh
authors.initials: F
authors.lastname: Jabeen
authors.forename: Bushra
authors.initials: B
authors.lastname: Mirza
authors.forename: Farzana Latif
authors.initials: FL
authors.lastname: Ansari
authors.forename: Ihsan
authors.initials: I
authors.lastname: Ul-Haq
authors.forename: Said A
authors.initials: SA
authors.lastname: El-Feky
authors.forename: Alan R
authors.initials: AR
authors.lastname: Katritzky