title: Bevacizumab in the treatment of five patients with breast cancer and brain metastases: Japan Breast Cancer Research Network-07 trial.
abstract: BACKGROUND
  Brain metastases from breast cancer occur in 20%-40% of patients, and the frequency has increased over time. New radiosensitizers and cytotoxic or cytostatic agents, and innovative techniques of drug delivery are still under investigation.
  
  
  METHODS
  Five patients with brain metastases who did not respond to whole-brain radiotherapy and then received bevacizumab combined with paclitaxel were identified using our database of records between 2011 and 2012. The clinicopathological data and outcomes for these patients were then reviewed.
  
  
  RESULTS
  The median time to disease progression was 86 days. Of five patients, two (40%) achieved a partial response, two had stable disease, and one had progressive disease. In addition, one patient with brain metastases had ptosis and diplopia due to metastases of the right extraocular muscles. However, not only the brain metastases, but also the ptosis and diplopia began to disappear after 1 month of treatment. The most common treatment-related adverse events (all grades) were hypertension (60%), neuropathy (40%), and proteinuria (20%). No grade 3 toxicity was seen. No intracranial hemorrhage was observed.
  
  
  CONCLUSIONS
  We present five patients with breast cancer and brain metastases, with benefits from systemic chemotherapy when combined with bevacizumab.
authors.affiliation: Department of Surgery, Kansai Medical University, Hirakata, Osaka ; Department of Internal Medicine, Seiko Hospital, Neyagawa, Osaka.
authors.forename: Daigo
authors.initials: D
authors.lastname: Yamamoto
authors.forename: Satoru
authors.initials: S
authors.lastname: Iwase
authors.forename: Yu
authors.initials: Y
authors.lastname: Tsubota
authors.forename: Noriko
authors.initials: N
authors.lastname: Sueoka
authors.forename: Chizuko
authors.initials: C
authors.lastname: Yamamoto
authors.forename: Kaoru
authors.initials: K
authors.lastname: Kitamura
authors.forename: Hiroki
authors.initials: H
authors.lastname: Odagiri
authors.forename: Yoshinori
authors.initials: Y
authors.lastname: Nagumo