title: Fast, extraction-free analysis of chlorinated phenols in well water by high-performance liquid chromatography-tandem mass spectrometry.
abstract: A fast and sensitive analytical method was developed for the chlorinated phenols included in the Canadian Drinking Water Guidelines without the need for costly, time-consuming sample extraction and concentration. Sensitivity and specificity were achieved by derivatization with dansyl chloride and detection via liquid chromatography-tandem mass spectrometry. The dansyl-modified analytes displayed method detection limits in the range of 0.01-1.0 μg/L, enabling the direct determination of chlorophenols from well water without sample enrichment. Recoveries (n=4 days) ranged from 91 to 101% and accuracies were between 79 and 116% (n=4). This method significantly increases sample throughput compared to the current EPA method for phenols in finished drinking water.
authors.affiliation: Vogon Laboratory Services Ltd., Unit 104, 90 Freeport Blvd. NE, Calgary, Alberta T3J 5J9, Canada. mnoestheden@vogonlabs.ca
authors.forename: Matthew
authors.initials: M
authors.lastname: Noestheden
authors.forename: Don
authors.initials: D
authors.lastname: Noot
authors.forename: Ralph
authors.initials: R
authors.lastname: Hindle
mesh_terms: D002851:Chromatography, High Pressure Liquid / Q000379:methods*; D006843:Hydrocarbons, Chlorinated / Q000032:analysis*; D010636:Phenols / Q000032:analysis*; D015203:Reproducibility of Results; D053719:Tandem Mass Spectrometry / Q000379:methods*; D014874:Water Pollutants, Chemical / Q000032:analysis*
chemical_list: D006843:Hydrocarbons, Chlorinated; D010636:Phenols; D014874:Water Pollutants, Chemical