title: [Role of DopR in the molecular mechanism of the dopamine control of juvenile hormone metabolism in female Drosophila].
abstract: The effect of a decreased availability of the D1-like dopamine receptor (DopR) in Drosophila (caused by DopR antagonist added into food) on the juvenile hormone (JH) synthesis rate in young female D. melanogaster has been studied. The JH degradation rate and the alkaline phosphatase (ALP) and tyrosine decarboxylase (TDC) activities were used as indicators of the JH synthesis rate. Treatment of the flies with butaclamol, a specific DopR antagonist, has been demonstrated to increase the JH degradation rate, and the stress reactivity of the system of JH metabolism and decrease the ALP activity and stress reactivity, and increase the TDC activity and stress reactivity. As shown earlier, all this indicates a decrease in the JH synthesis rate in young female drosophila with a decreased DopR availability. It is concluded that the activating effect of dopamine on JH synthesis in Drosophila is mediated by D1-like receptors.
authors.forename: E K
authors.initials: EK
authors.lastname: Karpova
authors.forename: E V
authors.initials: EV
authors.lastname: Bogomolova
authors.forename: I V
authors.initials: IV
authors.lastname: Romonova
authors.forename: N E
authors.initials: NE
authors.lastname: Gruntenko
authors.forename: I Iu
authors.initials: IIu
authors.lastname: Raushenbakh
mesh_terms: D000469:Alkaline Phosphatase / Q000378:metabolism; D000818:Animals; D002069:Butaclamol / Q000008:administration & dosage; D004298:Dopamine / Q000235:genetics / Q000378:metabolism; D029721:Drosophila Proteins / Q000235:genetics* / Q000378:metabolism; D004331:Drosophila melanogaster / Q000235:genetics*; D005260:Female; D018869:Heat-Shock Response / Q000187:drug effects; D007605:Juvenile Hormones / Q000096:biosynthesis / Q000235:genetics / Q000378:metabolism; D059748:Proteolysis / Q000187:drug effects; D011954:Receptors, Dopamine / Q000235:genetics* / Q000378:metabolism; D014445:Tyrosine Decarboxylase / Q000378:metabolism
chemical_list: C093147:Dop1R1 protein, Drosophila; D029721:Drosophila Proteins; D007605:Juvenile Hormones; D011954:Receptors, Dopamine; D002069:Butaclamol; D000469:Alkaline Phosphatase; D014445:Tyrosine Decarboxylase; D004298:Dopamine