title: Evolutionary genomics of immunoglobulin-encoding Loci in vertebrates.
abstract: Immunoglobulins (or antibodies) are an essential element of the jawed vertebrate adaptive immune response system. These molecules have evolved over the past 500 million years and generated highly specialized proteins that recognize an extraordinarily large number of diverse substances, collectively known as antigens. During vertebrate evolution the diversification of the immunoglobulin-encoding loci resulted in differences in the genomic organization, gene content, and ratio of functional genes and pseudogenes. The tinkering process in the immunoglobulin-encoding loci often gave rise to lineage-specific characteristics that were formed by selection to increase species adaptation and fitness. Immunoglobulin loci and their encoded antibodies have been shaped repeatedly by contrasting evolutionary forces, either to conserve the prototypic structure and mechanism of action or to generate alternative and diversified structures and modes of function. Moreover, evolution favored the development of multiple mechanisms of primary and secondary antibody diversification, which are used by different species to effectively generate an almost infinite collection of diverse antibody types. This review summarizes our current knowledge on the genomics and evolution of the immunoglobulin-encoding loci and their protein products in jawed vertebrates.
authors.affiliation: Department of Pathology and Laboratory Medicine, Emory Vaccine Center, School of Medicine, Emory University, USA.
authors.forename: Sabyasachi
authors.initials: S
authors.lastname: Das
authors.forename: Masayuki
authors.initials: M
authors.lastname: Hirano
authors.forename: Rea
authors.initials: R
authors.lastname: Tako
authors.forename: Chelsea
authors.initials: C
authors.lastname: McCallister
authors.forename: Nikolas
authors.initials: N
authors.lastname: Nikolaidis