title: Cognitive function after several years of antiretroviral therapy with stable central nervous system penetration score.
abstract: OBJECTIVE
  Previous studies in HIV-infected populations have yielded conflicting results on the effect of antiretroviral therapy (ART) on cognition. Our objective was to investigate the effect of several years of ART with stable central nervous system penetration effectiveness (CPE) score on neuropsychological performance in HIV-infected individuals.
  
  
  METHODS
  We analysed a clinical cohort of HIV-infected patients who initiated ART between June 2003 and December 2006 and maintained stable CPE scores. Patients were evaluated with a short neuropsychological battery. Using linear regression, we examined the relationship between results of cognitive tests and CPE scores in all patients.
  
  
  RESULTS
  Patients were divided into three similarly sized groups (CPE ≤ 1, CPE between 1.5 and 2.5, and CPE ≥ 2.5). We found that ART with high CPE scores was associated with poorer executive performances in HIV-1-infected patients.
  
  
  CONCLUSIONS
  These results suggest that cognitive performance in treated HIV-infected patients could be influenced by ART.
authors.affiliation: Internal Medicine A, Groupe Hospitalier Lariboisière-Fernand Widal-Saint Louis, APHP, Université Paris VII, Paris, France.
authors.forename: Y
authors.initials: Y
authors.lastname: Kahouadji
authors.forename: J
authors.initials: J
authors.lastname: Dumurgier
authors.forename: P
authors.initials: P
authors.lastname: Sellier
authors.forename: P
authors.initials: P
authors.lastname: Lapalus
authors.forename: V
authors.initials: V
authors.lastname: Delcey
authors.forename: Jf
authors.initials: J
authors.lastname: Bergmann
authors.forename: J
authors.initials: J
authors.lastname: Hugon
authors.forename: C
authors.initials: C
authors.lastname: Paquet
mesh_terms: D000328:Adult; D019380:Anti-HIV Agents / Q000009:adverse effects* / Q000494:pharmacology; D018791:CD4 Lymphocyte Count; D002490:Central Nervous System / Q000187:drug effects* / Q000503:physiopathology; D003071:Cognition / Q000187:drug effects*; D060825:Cognitive Dysfunction / Q000139:chemically induced* / Q000503:physiopathology; D004522:Educational Status; D005260:Female; D005602:France; D006679:HIV Seropositivity / Q000150:complications / Q000188:drug therapy* / Q000503:physiopathology; D006801:Humans; D016014:Linear Models; D008297:Male; D009483:Neuropsychological Tests; D013997:Time Factors
chemical_list: D019380:Anti-HIV Agents