title: Treatment of cerebellar cognitive affective syndrome with aripiprazole.
abstract: This report describes a patient who developed agitation, disorientation, visual hallucinations, inappropriate verbal outbursts, and impaired memory following resection of a choroid plexus papilloma. No medical, neurologic, or metabolic disorders unrelated to the surgery were identified. Five weeks following surgery, treatment with aripiprazole, a partial dopamine agonist, was started to address the delirious state. Improvements in agitation, orientation, memory, and executive functions, as well as a decrease in emotional lability, began within twenty-four hours and continued over the remainder of the inpatient hospitalization. Five months after initial resection, aripiprazole was discontinued without worsening of cognitive or emotional functions. Persistent difficulties with working memory, planning, judgment, and visuospatial skills were noted on neuropsychological examination six months following tumor removal. This case illustrated the therapeutic benefit of aripiprazole for treatment of mental status changes associated with resection of a posterior fossa tumor.
authors.affiliation: Department of Physical Medicine & Rehabilitation, Johns Hopkins School of Medicine, Baltimore, MD 21205, USA.
authors.forename: Jennifer L
authors.initials: JL
authors.lastname: Yap
authors.forename: Lee E
authors.initials: LE
authors.lastname: Wachtel
authors.forename: Edward S
authors.initials: ES
authors.lastname: Ahn
authors.forename: Jacqueline H
authors.initials: JH
authors.lastname: Sanz
authors.forename: Beth S
authors.initials: BS
authors.lastname: Slomine
authors.forename: Frank S
authors.initials: FS
authors.lastname: Pidcock
mesh_terms: D000293:Adolescent; D014150:Antipsychotic Agents / Q000627:therapeutic use*; D000068180:Aripiprazole; D002526:Cerebellar Diseases / Q000188:drug therapy* / Q000209:etiology; D003072:Cognition Disorders / Q000188:drug therapy* / Q000209:etiology; D005260:Female; D006801:Humans; D015192:Infratentorial Neoplasms / Q000601:surgery; D019964:Mood Disorders / Q000188:drug therapy* / Q000209:etiology; D019635:Neurosurgical Procedures; D020288:Papilloma, Choroid Plexus / Q000601:surgery; D010879:Piperazines / Q000627:therapeutic use*; D011183:Postoperative Complications / Q000188:drug therapy*; D015363:Quinolones / Q000627:therapeutic use*; D013577:Syndrome
chemical_list: D014150:Antipsychotic Agents; D010879:Piperazines; D015363:Quinolones; D000068180:Aripiprazole