title: Complete genome sequence of a novel human parechovirus.
abstract: Human parechoviruses (HPeVs) belonging to the family Picornaviridae are widely spread pathogens among young children. We report the complete genome sequence of a novel HPeV isolated from the stool sample of a hospitalized child with diarrhea in China. The genome consists of 7,305 nucleotides, excluding the 3' poly(A) tail, and has an open reading frame that maps between nucleotide positions 675 and 7217 and encodes a 2,180-amino-acid polyprotein. The genome sequence of the virus was sufficiently distinct from the 8 known HPeV types. Phylogenetic analysis based on the complete genome indicated that the HPeV strain represents a new genotype.
authors.affiliation: State Key Laboratory of Agricultural Microbiology, Division of Animal Infectious Disease, Huazhong Agricultural University, Wuhan, Hubei, China.
authors.forename: Chunmei
authors.initials: C
authors.lastname: Wang
authors.forename: Tongling
authors.initials: T
authors.lastname: Shan
authors.forename: Hao
authors.initials: H
authors.lastname: Zheng
authors.forename: Wu
authors.initials: W
authors.lastname: Tong
authors.forename: Fangzhou
authors.initials: F
authors.lastname: Chen
authors.forename: Han
authors.initials: H
authors.lastname: Hu
authors.forename: Qigai
authors.initials: Q
authors.lastname: He
authors.forename: Guangzhi
authors.initials: G
authors.lastname: Tong
mesh_terms: D002673:Child, Hospitalized; D002675:Child, Preschool; D002681:China; D016000:Cluster Analysis; D003967:Diarrhea / Q000821:virology; D005243:Feces / Q000821:virology; D016679:Genome, Viral; D006801:Humans; D008969:Molecular Sequence Data; D016366:Open Reading Frames; D030061:Parechovirus / Q000145:classification / Q000235:genetics* / Q000302:isolation & purification; D010802:Phylogeny; D010850:Picornaviridae Infections / Q000821:virology; D020815:Polyproteins / Q000235:genetics; D012367:RNA, Viral / Q000235:genetics*; D017422:Sequence Analysis, DNA; D014764:Viral Proteins / Q000235:genetics
chemical_list: D020815:Polyproteins; D012367:RNA, Viral; D014764:Viral Proteins