title: Silica exposure and serum angiotensin converting enzyme activity.
abstract: BACKGROUND
  Silicosis is known in industrial workers for centuries. Till recently, the mainstay of its diagnosis and progress was clinical examination of the respiratory system, pulmonary function test and chest radiography. Several biomarkers such as serum angiotensin converting enzyme (ACE) activity have been examined to determine the extent of silicosis.
  
  
  OBJECTIVE
  To elucidate the effect of age, gender, duration of exposure to silica dust, smoking habit, and pulmonary function status on the serum ACE activity among quartz stone workers without disease.
  
  
  METHODS
  A cross-sectional study was carried out on 134 (111 men and 14 women) workers of quartz stone crushing units were studied. Standard diagnostic criteria were used for diagnosing silicosis and tuberculosis. Pulmonary functions of the participants were also assessed.
  
  
  RESULTS
  The mean±SD age for participants was 26.1±6.3 years (26.6±6.3 for men and 21.9±4.3 for women). The mean±SD duration of exposure was 1.1±1.9 years. In the present study, only one case of silicosis and eight cases of tuberculosis were found. The mean±SD serum ACE levels for those with and without respiratory disease were 68.44±11.61, and 66.9±14.4 IU/L, respectively (p>0.05).
  
  
  CONCLUSIONS
  We could not observe any association between serum ACE activity and age, gender, duration of exposure, smoking habits and pulmonary function status. However, elevated levels of serum ACE was found in a solitary case of silicosis.
authors.affiliation: National Institute of Occupational Health, Meghani Nagar, Ahmedabad, Gujarat, India. drrajtiwarinioh@rediffmail.com
authors.forename: R R
authors.initials: RR
authors.lastname: Tiwari
authors.forename: A B
authors.initials: AB
authors.lastname: Karnik
authors.forename: Y K
authors.initials: YK
authors.lastname: Sharma
mesh_terms: D000328:Adult; D015897:Comorbidity; D005260:Female; D006801:Humans; D008297:Male; D007703:Peptidyl-Dipeptidase A / Q000097:blood*; D012829:Silicosis / Q000175:diagnosis / Q000453:epidemiology*; D012907:Smoking / Q000453:epidemiology; D055815:Young Adult
chemical_list: D007703:Peptidyl-Dipeptidase A