title: Binaphthyl-anchored antibacterial tripeptide derivatives with hydrophobic C-terminal amino acid variations.
abstract: The facile synthesis of seven new dicationic tripeptide benzyl ester derivatives, with hydrophobic group variations in the C-terminal amino acid component, is described. Moderate to good activity was seen against Gram-positive bacteria in vitro. One cyclohexyl-substituted compound 2c was tested more widely and showed good potency (MIC values ranging from 2-4 μg/mL) against antibiotic-resistant strains of Staphylococcus aureus and Enterococci (VRE, VSE), and against Staphylococcus epidermidis.
authors.affiliation: School of Chemistry, University of Wollongong, Wollongong, NSW 2522, Australia.
authors.forename: John B
authors.initials: JB
authors.lastname: Bremner
authors.forename: Paul A
authors.initials: PA
authors.lastname: Keller
authors.forename: Stephen G
authors.initials: SG
authors.lastname: Pyne
authors.forename: Mark J
authors.initials: MJ
authors.lastname: Robertson
authors.forename: K
authors.initials: K
authors.lastname: Sakthivel
authors.forename: Kittiya
authors.initials: K
authors.lastname: Somphol
authors.forename: Dean
authors.initials: D
authors.lastname: Baylis
authors.forename: Jonathan A
authors.initials: JA
authors.lastname: Coates
authors.forename: John
authors.initials: J
authors.lastname: Deadman
authors.forename: Dharshini
authors.initials: D
authors.lastname: Jeevarajah
authors.forename: David I
authors.initials: DI
authors.lastname: Rhodes