title: Future directions of delirium research and management.
abstract: Delirium is a prevalent organ dysfunction in critically ill patients associated with significant morbidity and mortality, requiring advancements in the clinical and research realms to improve patient outcomes. Increased clinical recognition and utilisation of delirium assessment tools, along with clarification of specific risk factors and presentations in varying patient populations, will be necessary in the future. To improve predictive models for outcomes, the continued development and implementation of delirium assessment tools and severity scoring systems will be required. The interplay between the pathophysiological pathways implicated in delirium and resulting clinical presentations and outcomes will need to guide the development of appropriate prevention and treatment protocols. Multicentre randomised controlled trials of interventional therapies will then need to be performed to test their ability to improve clinical outcomes. Physical and cognitive rehabilitation measures need to be further examined as additional means of improving outcomes from delirium in the hospital setting.
authors.affiliation: Department of Anesthesiology, Division of Critical Care, Vanderbilt University School of Medicine, Nashville, TN, USA. christopher.hughes@vanderbilt.edu
authors.forename: Christopher G
authors.initials: CG
authors.lastname: Hughes
authors.forename: Nathan E
authors.initials: NE
authors.lastname: Brummel
authors.forename: Eduard E
authors.initials: EE
authors.lastname: Vasilevskis
authors.forename: Timothy D
authors.initials: TD
authors.lastname: Girard
authors.forename: Pratik P
authors.initials: PP
authors.lastname: Pandharipande
mesh_terms: D035843:Biomedical Research / Q000639:trends*; D016638:Critical Illness; D003693:Delirium / Q000175:diagnosis / Q000503:physiopathology / Q000628:therapy*; D006801:Humans; D008962:Models, Theoretical; D017063:Outcome Assessment, Health Care; D011569:Psychiatric Status Rating Scales; D016032:Randomized Controlled Trials as Topic / Q000639:trends; D012307:Risk Factors; D012720:Severity of Illness Index