title: Rhodium(II) catalyzed diastereoselective reactions of diazoacetamides with isatins: an efficient approach to 3-hydroxy-3,3'-bioxindoles.
abstract: The 3,3'-bioxindole derivatives were constructed in a single step via an efficient Rh(2)(OAc)(4) catalyzed reaction of diazoacetamides with isatins. This novel method provides an alternative pathway towards 3-hydroxy-3,3'-bioxindoles in good yield (up to 78%) with high diastereoselectivity (up to 95 : 5).
authors.affiliation: Shanghai Engineering Research Centre of Molecular Therapeutics and New Drug Development, East China Normal University, Shanghai, 200062, China.
authors.forename: Ming
authors.initials: M
authors.lastname: Li
authors.forename: Li
authors.initials: L
authors.lastname: Zan
authors.forename: Dipak
authors.initials: D
authors.lastname: Prajapati
authors.forename: Wenhao
authors.initials: W
authors.lastname: Hu
mesh_terms: D000081:Acetamides / Q000737:chemistry*; D001391:Azo Compounds / Q000737:chemistry; D002384:Catalysis; D018360:Crystallography, X-Ray; D007211:Indoles / Q000138:chemical synthesis / Q000737:chemistry*; D007510:Isatin / Q000737:chemistry*; D008958:Models, Molecular; D000078183:Oxindoles; D012238:Rhodium / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D000081:Acetamides; D001391:Azo Compounds; D007211:Indoles; D000078183:Oxindoles; C022960:2-oxindole; D007510:Isatin; D012238:Rhodium