title: A study on neuroinflammation and NMDA receptor function in STZ (ICV) induced memory impaired rats.
abstract: Present study was designed to investigate the status of neuroinflammation and NMDA receptor function in STZ (ICV) induced memory impaired rats. STZ produced significant increase in proinflammatory cytokines (TNF-α and IL-1β), ROS, nitrite and mRNA and protein expression of iNOS and nNOS indicating a state of neuroinflammation in rat brain which was significantly prevented by Memantine and Ibuprofen treatment. STZ also significantly altered NMDA subunits, NR2A and NR2B protein and mRNA expression which were restored by Memantine only. The results suggest that neuroinflammatory markers might be involved in memory impairment via modulating the NMDA receptor in STZ induced memory impaired rats.
authors.affiliation: Division of Pharmacology, CSIR, Central Drug Research Institute, Lucknow (U.P.), 226001, India.
authors.forename: Shivika
authors.initials: S
authors.lastname: Rai
authors.forename: Pradeep K
authors.initials: PK
authors.lastname: Kamat
authors.forename: Chandishwar
authors.initials: C
authors.lastname: Nath
authors.forename: Rakesh
authors.initials: R
authors.lastname: Shukla
mesh_terms: D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use; D001921:Brain / Q000187:drug effects / Q000378:metabolism; D016207:Cytokines / Q000378:metabolism; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D004660:Encephalitis / Q000139:chemically induced* / Q000150:complications / Q000188:drug therapy / Q000378:metabolism; D018691:Excitatory Amino Acid Antagonists / Q000627:therapeutic use; D005786:Gene Expression Regulation / Q000187:drug effects; D007052:Ibuprofen / Q000627:therapeutic use; D007276:Injections, Intraventricular; D008297:Male; D018782:Maze Learning / Q000187:drug effects; D008559:Memantine / Q000627:therapeutic use; D008569:Memory Disorders / Q000139:chemically induced* / Q000150:complications / Q000188:drug therapy; D009043:Motor Activity / Q000187:drug effects; D052248:Nitric Oxide Synthase Type I / Q000235:genetics / Q000378:metabolism; D052247:Nitric Oxide Synthase Type II / Q000235:genetics / Q000378:metabolism; D009573:Nitrites / Q000378:metabolism; D012333:RNA, Messenger / Q000378:metabolism; D051381:Rats; D017207:Rats, Sprague-Dawley; D017382:Reactive Oxygen Species / Q000378:metabolism; D016194:Receptors, N-Methyl-D-Aspartate / Q000235:genetics / Q000378:metabolism*; D018709:Statistics, Nonparametric; D013311:Streptozocin / Q000633:toxicity*
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D016207:Cytokines; D018691:Excitatory Amino Acid Antagonists; D007052:Ibuprofen; D008559:Memantine; D052248:Nitric Oxide Synthase Type I; D052247:Nitric Oxide Synthase Type II; D009573:Nitrites; D012333:RNA, Messenger; D017382:Reactive Oxygen Species; D016194:Receptors, N-Methyl-D-Aspartate; D013311:Streptozocin; C121001:NR2B NMDA receptor