title: [Relationship between specific immunocyte and pseudoanaphylactoid reactions induced by Shuanghuanglian injection].
abstract: OBJECTIVE
  To investigate the relationship between specific immunocyte and pseudoanaphylactoid reactions (PR) induced by Shuanghuanglian injection (SHLI).
  
  
  METHODS
  ICR mice, SCID mice and BALB/C athymic mouse were divided into different test groups, the mice were intravenously injected with solutions of different concentration of SHLI, positive control Compound 48/80 and normal sodium. All test substances were mixed with 0. 4% Evans blue. The reaction and vascular permeability of the ears were observed and measured 30 min after SHLI injected.
  
  
  RESULTS
  SHLI of 300, 600 mg x kg(-1) caused obvious vascular hyperpermeability in ICR mice, but the same dose of SHLI didn't cause vascular hyperpermeability in SCID mice and BALB/C athymic mouse.
  
  
  CONCLUSIONS
  SHLI in equivalent and 2 times the clinical dose can cause PR in ICR mice, but the same dose of SHLI can't cause PR in SCID mice and BALB/C athymic mouse, so specific immunocyte maybe take part in the SHLI-induced PR.
authors.affiliation: Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China. yiyan800109@yahoo.com.cn
authors.forename: Yan
authors.initials: Y
authors.lastname: Yi
authors.forename: Aihua
authors.initials: A
authors.lastname: Liang
authors.forename: Chunying
authors.initials: C
authors.lastname: Li
authors.forename: Yong
authors.initials: Y
authors.lastname: Zhao
authors.forename: Yunting
authors.initials: Y
authors.lastname: Wang
authors.forename: Guiqin
authors.initials: G
authors.lastname: Li
mesh_terms: D000707:Anaphylaxis / Q000139:chemically induced* / Q000276:immunology*; D000818:Animals; D004365:Drugs, Chinese Herbal / Q000633:toxicity*; D007107:Immune System / Q000187:drug effects*; D007267:Injections / Q000379:methods; D051379:Mice; D008807:Mice, Inbred BALB C; D008813:Mice, Inbred ICR; D016513:Mice, SCID
chemical_list: D004365:Drugs, Chinese Herbal; C516400:shuang-huang-lian