title: Management of large aggressive nonfunctional pituitary tumors: experimental medical options when surgery and radiation fail.
abstract: Pituitary adenomas are generally considered benign tumors; however, a subset of these tumors displays aggressive behavior and are not easily cured. The protocol for nonsurgical treatment of aggressive pituitary lesions is less standardized than that of other central nervous system tumors. Aggressive surgical treatment, radiation, dopamine agonists, antiangiogenic drugs, and other chemotherapeutics all have roles in the treatment of aggressive pituitary tumors. More studies are needed to improve outcomes for patients with aggressive pituitary tumors.
authors.affiliation: Department of Neurosurgery, Emory University, Atlanta, GA 30322, USA. brandon.miller@emory.edu
authors.forename: Brandon A
authors.initials: BA
authors.lastname: Miller
authors.forename: W Caleb
authors.initials: WC
authors.lastname: Rutledge
authors.forename: Adriana G
authors.initials: AG
authors.lastname: Ioachimescu
authors.forename: Nelson M
authors.initials: NM
authors.lastname: Oyesiku
mesh_terms: D003131:Combined Modality Therapy; D006801:Humans; D010911:Pituitary Neoplasms / Q000188:drug therapy* / Q000532:radiotherapy / Q000601:surgery; D015175:Prolactinoma / Q000188:drug therapy / Q000532:radiotherapy; D016896:Treatment Outcome