title: Silica gel-mediated organic reactions under organic solvent-free conditions.
abstract: Silica gel was found to be an excellent medium for some useful organic transformations under organic solvent-free conditions, such as (1) the Friedel-Crafts-type nitration of arenes using commercial aqueous 69% nitric acid alone at room temperature, (2) one-pot Wittig-type olefination of aldehydes with activated organic halides in the presence of tributyl- or triphenylphosphine and Hunig's base, and (3) the Morita-Baylis-Hillman reaction of aldehydes with methyl acrylate. After the reactions, the desired products were easily obtained in good to excellent yields through simple manipulation.
authors.affiliation: Institute for Materials Chemistry and Engineering (IMCE), Kyushu University, Hakozaki, Higashi-ku, Fukuoka 812-8581, Japan.
authors.forename: Satoaki
authors.initials: S
authors.lastname: Onitsuka
authors.forename: Yong Zhi
authors.initials: YZ
authors.lastname: Jin
authors.forename: Ajam C
authors.initials: AC
authors.lastname: Shaikh
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Furuno
authors.forename: Junji
authors.initials: J
authors.lastname: Inanaga
mesh_terms: D000447:Aldehydes / Q000737:chemistry; D002384:Catalysis; D017942:Nitric Acid / Q000737:chemistry; D009930:Organic Chemicals / Q000737:chemistry*; D058428:Silica Gel / Q000737:chemistry*; D012997:Solvents / Q000737:chemistry*
chemical_list: D000447:Aldehydes; D009930:Organic Chemicals; D012997:Solvents; D017942:Nitric Acid; D058428:Silica Gel