title: Carbenoid-mediated N-O bond insertion and its application in the synthesis of pyridines.
abstract: Highly efficient synthesis of 3-hydroxypyridines has been developed based on carbenoid-mediated N-O bond insertion. Treatment of δ-diazo oxime ethers with dirhodium complex Rh(2)(tfacam)(4) rapidly provides a variety of pyridines in 5-10 minutes in good to excellent yields.
authors.affiliation: Division of Chemistry and Biological Chemistry, School of Physical and Mathematical Sciences, Nanyang Technological University, 637371, Singapore.
authors.forename: Xinxin
authors.initials: X
authors.lastname: Qi
authors.forename: Lu
authors.initials: L
authors.lastname: Dai
authors.forename: Cheol-Min
authors.initials: CM
authors.lastname: Park
mesh_terms: D056831:Coordination Complexes / Q000737:chemistry; D004987:Ethers / Q000737:chemistry; D008697:Methane / Q000031:analogs & derivatives* / Q000737:chemistry; D009584:Nitrogen / Q000737:chemistry; D010091:Oximes / Q000737:chemistry; D010100:Oxygen / Q000737:chemistry; D011725:Pyridines / Q000138:chemical synthesis / Q000737:chemistry*; D012238:Rhodium / Q000737:chemistry
chemical_list: D056831:Coordination Complexes; D004987:Ethers; D010091:Oximes; D011725:Pyridines; C030011:carbene; D012238:Rhodium; D009584:Nitrogen; D008697:Methane; D010100:Oxygen