title: [Klotho and phosphate metabolism].
abstract: α-Klotho was first identified as an aging gene and was later shown to be a regulator of mineral metabolism. Then, α-Klotho was reported to function as an obligate coreceptor for fibroblast growth factor 23 (FGF23). Phosphrus regulation of FGF23/Klotho axis is slow. On the other hand, α-Klotho is a key player that integrates "a multi-step regulatory system of calcium homeostasis" that rapidly adjusts the extracellular calcium concentration. In addition to its membrane-bound function as a co-receptor for fibroblast growth factor 23, soluble Klotho exerts effects as a circulating substance in plasma and urine. The Klotho protein not only serves as a coreceptor for FGF23, but also functions as a humoral factor.
authors.affiliation: Division of Nephrology and Hypertension, Department of Internal Medicine, The Jikei University School of Medicine, Japan.
authors.forename: Keitaro
authors.initials: K
authors.lastname: Yokoyama
mesh_terms: D000818:Animals; D002118:Calcium / Q000378:metabolism; D000089703:Fibroblast Growth Factor-23; D005346:Fibroblast Growth Factors / Q000378:metabolism*; D005966:Glucuronidase / Q000378:metabolism*; D006706:Homeostasis / Q000502:physiology*; D006801:Humans; D007668:Kidney / Q000378:metabolism; D000090265:Klotho Proteins; D010710:Phosphates / Q000378:metabolism*
chemical_list: C000717427:FGF23 protein, human; D010710:Phosphates; D005346:Fibroblast Growth Factors; D000089703:Fibroblast Growth Factor-23; D005966:Glucuronidase; D000090265:Klotho Proteins; D002118:Calcium