title: [Prospective controlled trial of safety of human umbilical cord derived-mesenchymal stem cell transplantation in patients with decompensated liver cirrhosis].
abstract: OBJECTIVE
  To evaluate the safety of human umbilical cord derived-mesenchymal stem cell (UC-MSC) transplantation therapy in patients with decompensated liver cirrhosis.
  
  
  METHODS
  UC-MSCs were transplanted intravenously into patients with decompensated liver cirrhosis. Serum levels of glucose (GLU), total cholesterol (TC), blood urea nitrogen (BUN), alpha fetoprotein (AFP), white blood cells (WBC), and prothrombin activity (PA) were detected at different time points after UC-MSCs transplantation.
  
  
  RESULTS
  Most UC-MSC transplanted patients experienced an improvement in quality of life, to varying degrees. With the exception of low-grade fever in a few patients, side effects and oncogenic events were rare (treatment group: 1/38 vs. control group: 1/16; P more than 0.05). The UC-MSCs transplantation showed no effect on GLU, TC, BUN, AFP, WBC, or PA.
  
  
  CONCLUSIONS
  UC-MSCs transplantation in patients with decompensated liver cirrhosis is safe and may improve the patient's quality of life.
authors.affiliation: The Research Center For Biological Therapy, Beijing 302 Hospital, Beijing, China.
authors.forename: Hu
authors.initials: H
authors.lastname: Lin
authors.forename: Zheng
authors.initials: Z
authors.lastname: Zhang
authors.forename: Ming
authors.initials: M
authors.lastname: Shi
authors.forename: Ruo-nan
authors.initials: RN
authors.lastname: Xu
authors.forename: Jun-liang
authors.initials: JL
authors.lastname: Fu
authors.forename: Hua
authors.initials: H
authors.lastname: Geng
authors.forename: Yuan-yuan
authors.initials: YY
authors.lastname: Li
authors.forename: Shuang-jie
authors.initials: SJ
authors.lastname: Yu
authors.forename: Li-ming
authors.initials: LM
authors.lastname: Chen
authors.forename: Sa
authors.initials: S
authors.lastname: Lv
authors.forename: Fu-sheng
authors.initials: FS
authors.lastname: Wang
mesh_terms: D000328:Adult; D000368:Aged; D036101:Cord Blood Stem Cell Transplantation / Q000009:adverse effects*; D005260:Female; D006801:Humans; D008103:Liver Cirrhosis / Q000150:complications / Q000601:surgery*; D008297:Male; D045164:Mesenchymal Stem Cell Transplantation / Q000009:adverse effects*; D008875:Middle Aged; D011446:Prospective Studies