title: A highly sensitive fluorescent probe based on simple pyrazoline for Zn2+ in living neuron cells.
abstract: We develop a pyrazoline-based fluorescent sensor for biological Zn(2+) detection. The sensor shows good binding selectivity for Zn(2+) over competing metal with 40-fold fluorescence enhancement in response to Zn(2+). The new probe is cell-permeable and can be used to detect intracellular zinc ions in living neuron cells.
authors.affiliation: Institute of Organic Chemistry, School of Chemistry and Chemical Engineering, Shandong University, Jinan 250100, PR China.
authors.forename: Zhe
authors.initials: Z
authors.lastname: Zhang
authors.forename: Fang-Wu
authors.initials: FW
authors.lastname: Wang
authors.forename: Sheng-Qing
authors.initials: SQ
authors.lastname: Wang
authors.forename: Fei
authors.initials: F
authors.lastname: Ge
authors.forename: Bao-Xiang
authors.initials: BX
authors.lastname: Zhao
authors.forename: Jun-Ying
authors.initials: JY
authors.lastname: Miao
mesh_terms: D000818:Animals; D005456:Fluorescent Dyes / Q000138:chemical synthesis / Q000737:chemistry*; D015394:Molecular Structure; D009474:Neurons / Q000737:chemistry* / Q000166:cytology; D016716:PC12 Cells; D011720:Pyrazoles / Q000138:chemical synthesis / Q000737:chemistry*; D051381:Rats; D015032:Zinc / Q000032:analysis*
chemical_list: D005456:Fluorescent Dyes; D011720:Pyrazoles; D015032:Zinc