title: Williams-Beuren Syndrome and Burkitt Leukemia.
abstract: Williams-Beuren Syndrome (WBS) is associated with constitutional deletion of 7q11.23, which includes the elastin gene. Cytogenetic abnormalities of chromosome 7 are frequently described in several human malignancies. Here, we report Burkitt Leukemia in an 8-year-old boy with WBS. In this patient, constitutional deletion of chromosome 7q11.23 including BCL7B was confirmed. WBS may predispose patients to Burkitt Leukemia.
authors.affiliation: Division of Hematology/Oncology, The Hospital for Sick Children, Toronto, ON, Canada. nataliya.zhukova@sickkids.ca
authors.forename: Nataliya
authors.initials: N
authors.lastname: Zhukova
authors.forename: Ahmed
authors.initials: A
authors.lastname: Naqvi
mesh_terms: D002051:Burkitt Lymphoma / Q000188:drug therapy / Q000209:etiology*; D002648:Child; D002872:Chromosome Deletion; D002897:Chromosomes, Human, Pair 7 / Q000235:genetics*; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D008297:Male; D010641:Phenotype; D011379:Prognosis; D011506:Proteins / Q000235:genetics*; D018980:Williams Syndrome / Q000150:complications / Q000188:drug therapy / Q000235:genetics*
chemical_list: C116387:BCL7B protein, human; D011506:Proteins