title: Palladium-catalyzed mono- and double-carbonylation of indoles with amines controllably leading to amides and α-ketoamides.
abstract: A novel and efficient double-carbonylation of indoles with primary or secondary amines to yield indole-3-α-ketoamides has been developed and bioactive molecules could be one-pot synthesized using the current methodology, which could also be selectively switched to mono-carbonylation to afford indole-3-amides only by a slight modification of reaction conditions.
authors.affiliation: State Key Laboratory for Oxo Synthesis and Selective Oxidation, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, Lanzhou, 730000, China.
authors.forename: Qi
authors.initials: Q
authors.lastname: Xing
authors.forename: Lijun
authors.initials: L
authors.lastname: Shi
authors.forename: Rui
authors.initials: R
authors.lastname: Lang
authors.forename: Chungu
authors.initials: C
authors.lastname: Xia
authors.forename: Fuwei
authors.initials: F
authors.lastname: Li