title: Synthesis of chiral bis-oxazines: a preliminary assessment of helical conformational framework.
abstract: A series of novel naphthalene attached bis-oxazines were synthesized and characterized. The bis-oxazines were studied by VT-NMR analysis to assess the possibility of conformational twist. The bis-oxazine prepared from (l)-methylvalinate show a helical conformational twist in the single crystal X-ray analysis. Three isomers of bis-oxazines were prepared from chiral α-methylbenzyl amines, the meso isomer showed small optical rotation probably indicating the helical conformational twist in the molecule.
authors.affiliation: Department of Chemistry, Faculty of Science, M.S. University of Baroda, Vadodara 390 002, India.
authors.forename: Harish R
authors.initials: HR
authors.lastname: Talele
authors.forename: Ashutosh V
authors.initials: AV
authors.lastname: Bedekar
mesh_terms: D000588:Amines / Q000737:chemistry; D008958:Models, Molecular; D008968:Molecular Conformation; D010078:Oxazines / Q000138:chemical synthesis* / Q000737:chemistry*
chemical_list: D000588:Amines; D010078:Oxazines