title: Angiographic features and cardiovascular risk factors in human immunodeficiency virus-infected patients with first-time acute coronary syndrome.
abstract: A matched cohort study was conducted comparing patients with first-time acute coronary syndromes infected with human immunodeficiency virus (HIV) to non-HIV-infected patients with and without diabetes matched for smoking, gender, and type of acute coronary syndrome who underwent first-time coronary angiography. A total of 48 HIV-infected patients were identified from a national database. Coronary angiography showed that the HIV-infected patients had significantly fewer lesions with classification B2/C than the 2 control groups (p <0.001) but the same extent of multivessel disease. The HIV-infected patients were a decade younger than the non-HIV-infected controls and had significantly higher concentrations of total cholesterol (6.3 vs 4.8 and 4.5 mmol/L, p <0.0001), low-density lipoprotein (4.0 vs 2.9 and 2.5 mmol/L, p <0.001), and triglycerides (2.8 vs 1.0 and 1.4 mmol/L, p <0.01) compared to the nondiabetic and diabetic non-HIV-infected groups, respectively. In conclusion, HIV-infected patients with first-time acute coronary syndromes have fewer complex lesions than non-HIV-infected patients. This finding supports the idea that the pathogenesis of atherosclerotic disease in HIV patients is different from that in the general population.
authors.affiliation: Department of Infectious Diseases, Copenhagen University Hospital, Hvidovre, Denmark. andreas.knudsen@hvh.regionh.dk
authors.forename: Andreas
authors.initials: A
authors.lastname: Knudsen
authors.forename: Anders B
authors.initials: AB
authors.lastname: Mathiasen
authors.forename: René H
authors.initials: RH
authors.lastname: Worck
authors.forename: Jens
authors.initials: J
authors.lastname: Kastrup
authors.forename: Jan
authors.initials: J
authors.lastname: Gerstoft
authors.forename: Terese L
authors.initials: TL
authors.lastname: Katzenstein
authors.forename: Andreas
authors.initials: A
authors.lastname: Kjaer
authors.forename: Anne-Mette
authors.initials: AM
authors.lastname: Lebech
mesh_terms: D054058:Acute Coronary Syndrome / Q000150:complications / Q000000981:diagnostic imaging* / Q000453:epidemiology; D000328:Adult; D000368:Aged; D017023:Coronary Angiography; D003718:Denmark / Q000453:epidemiology; D005260:Female; D005500:Follow-Up Studies; D006678:HIV; D015658:HIV Infections / Q000150:complications* / Q000453:epidemiology; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D012307:Risk Factors