title: DRD1 rs4532 polymorphism: a potential pharmacogenomic marker for treatment response to antipsychotic drugs.
abstract: We investigated the association of dopamine receptor D1 gene (DRD1) rs4532 polymorphism with antipsychotic treatment response in schizophrenia. We have analyzed 124 patients with schizophrenia, consisting of 59 treatment resistant (TR) and 65 non-TR. We found an association between G-allele and TR schizophrenia (p=0.001; adjusted OR=2.71). Setting the common AA-genotype as reference, the GG-homozygous presented a five-fold risk compared to AA-homozygous (p=0.010; OR=5.56) with an intermediate result for AG-genotype (p=0.030; adjusted OR=2.64). The DRD1 rs4532 polymorphism showed a dose-response gradient with increased risk for treatment resistance and may be a potential pharmacogenetic marker for antipsychotic drug treatment response.
authors.affiliation: Disciplina de Genética, Departamento de Morfologia e Genética, Universidade Federal de Sao Paulo (UNIFESP), São Paulo, Brazil. vanessakaota@gmail.com
authors.forename: Vanessa Kiyomi
authors.initials: VK
authors.lastname: Ota
authors.forename: Letícia Nery
authors.initials: LN
authors.lastname: Spíndola
authors.forename: Ary
authors.initials: A
authors.lastname: Gadelha
authors.forename: Airton Ferreira
authors.initials: AF
authors.lastname: dos Santos Filho
authors.forename: Marcos Leite
authors.initials: ML
authors.lastname: Santoro
authors.forename: Denise Maria
authors.initials: DM
authors.lastname: Christofolini
authors.forename: Fernanda Teixeira
authors.initials: FT
authors.lastname: Bellucco
authors.forename: Ândrea Kely
authors.initials: ÂK
authors.lastname: Ribeiro-dos-Santos
authors.forename: Sidney
authors.initials: S
authors.lastname: Santos
authors.forename: Jair de Jesus
authors.initials: Jde J
authors.lastname: Mari
authors.forename: Maria Isabel
authors.initials: MI
authors.lastname: Melaragno
authors.forename: Rodrigo Affonseca
authors.initials: RA
authors.lastname: Bressan
authors.forename: Marilia de Arruda Cardoso
authors.initials: Mde A
authors.lastname: Smith
authors.forename: Sintia Iole
authors.initials: SI
authors.lastname: Belangero
mesh_terms: D000328:Adult; D000483:Alleles; D014150:Antipsychotic Agents / Q000627:therapeutic use*; D004305:Dose-Response Relationship, Drug; D005260:Female; D056726:Genetic Association Studies; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D010045:Outpatients; D010597:Pharmacogenetics; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D011569:Psychiatric Status Rating Scales; D017447:Receptors, Dopamine D1 / Q000235:genetics*; D012559:Schizophrenia / Q000188:drug therapy* / Q000235:genetics*
chemical_list: D014150:Antipsychotic Agents; D017447:Receptors, Dopamine D1