title: Quantitative Tc-99m DTPA renal transplant scintigraphy predicts graft survival in the very early postoperative period.
abstract: BACKGROUND
  Early evaluation of renal allograft prognosis is important for identification and targeted management of 'at-risk' grafts but is difficult in the absence of established tests. Tc-99m diethylene triamine pentaacetic acid renal transplant scintigraphy is a useful noninvasive method for assessing graft function. We aimed to assess the relative role of quantitative scintigraphic parameters in the immediate postoperative period for the assessment of short-term and long-term prognoses.
  
  
  METHODS
  Data from 290 dynamic renal transplant scintigraphy procedures, performed on 161 recipients on day 1 (D1) or day 4 (D4) after transplantation, were analysed to derive various perfusion parameters [Kirchner's Index, Hilson's Index (HI), kidney-to-aorta ratio and ΔP] as well as nonperfusion parameters (graft washout t (1/2), P : PI ratio, P : U ratio, R20/3, T10 and T20) using regions of interest within the whole renal graft and iliac artery. Information on graft survival up to 1 year (as a measure of short-term prognosis) and serum creatinine at 1 year (regarded as a predictor for longer-term prognosis) was collected. Mann-Whitney tests, receiver-operating characteristic curve analyses and odds ratios were used to assess the utility of each parameter in stratifying the risk for graft failure within 1 year. Correlations between each parameter and 1-year serum creatinine were tested using Spearman's rank correlation.
  
  
  RESULTS
  Eleven grafts failed within 1 year. All perfusion parameters on both D1 and D4 showed significant differences between the failure and survival groups (P=0.026-0.0005). No significant between-group differences were observed for nonperfusion parameters except for R20/3 on D1 (P=0.0298). Receiver-operating characteristic analysis showed moderate accuracy for HI and ΔP on both D1 and D4 (area under the curve: 0.73-0.84); ΔP of longer than 6.0 s on D4 was associated with 24.9 times higher relative risk for graft failure within 1 year (sensitivity 88% and specificity 83%). For the assessment of long-term prognosis, a moderate correlation was found between most perfusion parameters (Kirchner's Index, HI and kidney-to-aorta ratio on both D1 and D4) and 1-year serum creatinine (ρ=0.40-0.50; P ≤ 0.0001). The nonperfusion parameters showed only weak correlation.
  
  
  CONCLUSIONS
  Perfusion assessment using HI and ΔP is useful in the assessment of graft prognosis. This can be achieved as early as D1 and D4 after transplantation.
authors.affiliation: Department of Nuclear Medicine and PET, John Hunter Hospital, University of Newcastle, Newcastle, New South Wales, Australia.
authors.forename: Sandeep K
authors.initials: SK
authors.lastname: Gupta
authors.forename: Guy
authors.initials: G
authors.lastname: Lewis
authors.forename: Kerry
authors.initials: K
authors.lastname: Rogers
authors.forename: John
authors.initials: J
authors.lastname: Attia
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D003404:Creatinine / Q000097:blood; D005260:Female; D006085:Graft Survival; D006801:Humans; D007668:Kidney / Q000000981:diagnostic imaging* / Q000502:physiology; D016030:Kidney Transplantation; D008297:Male; D008875:Middle Aged; D011184:Postoperative Period; D011379:Prognosis; D011877:Radionuclide Imaging; D012189:Retrospective Studies; D016284:Technetium Tc 99m Pentetate; D013997:Time Factors; D055815:Young Adult
chemical_list: D003404:Creatinine; D016284:Technetium Tc 99m Pentetate