title: Copy number variation in subjects with major depressive disorder who attempted suicide.
abstract: BACKGROUND
  Suicide is one of the top ten leading causes of death in North America and represents a major public health burden, particularly for people with Major Depressive disorder (MD). Many studies have suggested that suicidal behavior runs in families, however, identification of genomic loci that drive this efffect remain to be identified.
  
  
  RESULTS
  Using subjects collected as part of STAR D, we genotyped 189 subjects with MD with history of a suicide attempt and 1073 subjects with Major Depressive disorder that had never attempted suicide. Copy Number Variants (CNVs) were called in Birdsuite and analyzed in PLINK. We found a set of CNVs present in the suicide attempter group that were not present in in the non-attempter group including in SNTG2 and MACROD2 - two brain expressed genes previously linked to psychopathology; however, these results failed to reach genome-wide signifigance.
  
  
  CONCLUSIONS
  These data suggest potential CNVs to be investigated further in relation to suicide attempts in MD using large sample sizes.
authors.affiliation: Center for Human Genetic Research, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, United States of America.
authors.forename: Roy H
authors.initials: RH
authors.lastname: Perlis
authors.forename: Douglas
authors.initials: D
authors.lastname: Ruderfer
authors.forename: Steven P
authors.initials: SP
authors.lastname: Hamilton
authors.forename: Carl
authors.initials: C
authors.lastname: Ernst
mesh_terms: D001921:Brain / Q000378:metabolism* / Q000503:physiopathology; D015331:Cohort Studies; D056915:DNA Copy Number Variations; D003865:Major Depressive Disorder / Q000235:genetics* / Q000378:metabolism / Q000523:psychology; D005260:Female; D020869:Gene Expression Profiling; D055106:Genome-Wide Association Study; D005838:Genotype; D006801:Humans; D008297:Male; D008390:Markov Chains; D008562:Membrane Glycoproteins; D008565:Membrane Proteins / Q000235:genetics; D009124:Muscle Proteins / Q000235:genetics; D009656:North America; D020411:Oligonucleotide Array Sequence Analysis; D012307:Risk Factors; D013406:Suicide, Attempted / Q000523:psychology*
chemical_list: C404492:FLRT3 protein, human; D008562:Membrane Glycoproteins; D008565:Membrane Proteins; D009124:Muscle Proteins; C410037:SNTG2 protein, human