title: Synthesis, structures and antibacterial activities of benzoylthiourea derivatives and their complexes with cobalt.
abstract: Four new thiocarbonyl fluorobenzamides and their complexes with cobalt have been synthesized and characterized by elemental analysis, FTIR, and (1)H NMR. Five crystal structures of the thioylbenzamides complexes of Co(PTCB)(3), Co(2FPTCB)(3), Co(4FPTCB)(3), Co(2FMTCB)(2) and Co(4FMTCB)(3) have been determined by X-ray diffraction. The antibacterial properties of these compounds against the bacteria, E. coli, Staphylococcus aureus, B. subtilis, P. aeruginosa, and Shewanella sp. were investigated. The experiments showed that both compounds and the complexes had the antibacterial activities against all of the studied bacteria. The thioylbenzamides had stronger controls for the bacteria of E. coli, S. aureus, B. subtilis and P. aeruginosa than their corresponding cobalt complexes. There was the contrary result against the bacteria of Shewanella sp. The para-substitution of fluorine atom increased antibacterial activities, while fluorine atom was substituted on ortho-benzoyl, the antibacterial activity weakened. The thioylbenzamides linked to piperidine instead of a morpholine group may increase the antibacterial activities.
authors.affiliation: College of Chemistry, Chemical Engineering and Materials Science, Soochow University, 199 Ren'ai Road, Suzhou, 215123, PR China.
authors.forename: Wen
authors.initials: W
authors.lastname: Yang
authors.forename: Huanhuan
authors.initials: H
authors.lastname: Liu
authors.forename: Mengying
authors.initials: M
authors.lastname: Li
authors.forename: Fan
authors.initials: F
authors.lastname: Wang
authors.forename: Weiqun
authors.initials: W
authors.lastname: Zhou
authors.forename: Jianfen
authors.initials: J
authors.lastname: Fan
mesh_terms: D000900:Anti-Bacterial Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D003035:Cobalt / Q000737:chemistry*; D018360:Crystallography, X-Ray; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests; D008958:Models, Molecular; D017550:Spectroscopy, Fourier Transform Infrared; D013329:Structure-Activity Relationship; D013890:Thiourea / Q000737:chemistry* / Q000494:pharmacology*; D014961:X-Ray Diffraction
chemical_list: D000900:Anti-Bacterial Agents; D003035:Cobalt; D013890:Thiourea