title: Biomaterial-associated infection: locating the finish line in the race for the surface.
abstract: Biomaterial-associated infections occur on both permanent implants and temporary devices for restoration or support of human functions. Despite increasing use of biomaterials in an aging society, comparatively few biomaterials have been designed that effectively reduce the incidence of biomaterial-associated infections. This review provides design guidelines for infection-reducing strategies based on the concept that the fate of biomaterial implants or devices is a competition between host tissue cell integration and bacterial colonization at their surfaces.
authors.affiliation: Department of BioMedical Engineering, University Medical Center Groningen, University of Groningen, Antonius Deusinglaan 1, 9713 AV Groningen, Netherlands.
authors.forename: Henk J
authors.initials: HJ
authors.lastname: Busscher
authors.forename: Henny C
authors.initials: HC
authors.lastname: van der Mei
authors.forename: Guruprakash
authors.initials: G
authors.lastname: Subbiahdoss
authors.forename: Paul C
authors.initials: PC
authors.lastname: Jutte
authors.forename: Jan J A M
authors.initials: JJ
authors.lastname: van den Dungen
authors.forename: Sebastian A J
authors.initials: SA
authors.lastname: Zaat
authors.forename: Marcus J
authors.initials: MJ
authors.lastname: Schultz
authors.forename: David W
authors.initials: DW
authors.lastname: Grainger
mesh_terms: D000818:Animals; D001672:Biocompatible Materials / Q000009:adverse effects*; D054884:Host-Pathogen Interactions; D006801:Humans; D020007:Implants, Experimental / Q000009:adverse effects; D011474:Prosthesis Design; D016459:Prosthesis-Related Infections / Q000382:microbiology / Q000517:prevention & control*; D023822:Tissue Engineering
chemical_list: D001672:Biocompatible Materials