title: Lack of association between PICALM rs3851179 polymorphism and Alzheimer's disease in Chinese population and APOEε4-negative subgroup.
abstract: Recently, the association between PICALM rs3851179 polymorphism and Alzheimer's disease (AD) was investigated in the Chinese population by 3 independent studies. However, both allele and genotype tests failed to reveal any association. The association was identified only in the APOEε4-negative subgroup. We think that the failure to replicate the association may be because of the relatively small sample size. In this research, we reinvestigated the association using all the samples from these 3 studies (n = 2486, and 1202 cases and 1284 control subjects). We failed to replicate this association between the rs3851179 polymorphism and AD in all samples and the APOEε4-negative subgroup. Our results indicate that rs3851179 may not be an AD susceptibility locus in the Chinese population and the APOEε4-negative subgroup.
authors.affiliation: Institute of Neurology, Guangdong Medical College, District of Xiashan, Zhanjiang, Guangdong, China. liuguiyou1981@163.com
authors.forename: Guiyou
authors.initials: G
authors.lastname: Liu
authors.forename: Liangcai
authors.initials: L
authors.lastname: Zhang
authors.forename: Rennan
authors.initials: R
authors.lastname: Feng
authors.forename: Mingzhi
authors.initials: M
authors.lastname: Liao
authors.forename: Yongshuai
authors.initials: Y
authors.lastname: Jiang
authors.forename: Zugen
authors.initials: Z
authors.lastname: Chen
authors.forename: Bin
authors.initials: B
authors.lastname: Zhao
authors.forename: Keshen
authors.initials: K
authors.lastname: Li
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000453:epidemiology* / Q000235:genetics*; D053327:Apolipoprotein E4 / Q000235:genetics*; D002681:China / Q000453:epidemiology; D005260:Female; D056726:Genetic Association Studies; D005819:Genetic Markers / Q000235:genetics; D020022:Genetic Predisposition to Disease / Q000453:epidemiology* / Q000235:genetics*; D006801:Humans; D015994:Incidence; D008297:Male; D034041:Monomeric Clathrin Assembly Proteins / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D012307:Risk Factors
chemical_list: D053327:Apolipoprotein E4; D005819:Genetic Markers; D034041:Monomeric Clathrin Assembly Proteins; C439003:PICALM protein, human