title: Hypertriglyceridemia is associated with insulin levels in adult cystic fibrosis patients.
abstract: BACKGROUND
  Recent studies have identified hypertriglyceridemic cystic fibrosis patients (CF-TG). However, whether hypertriglyceridemia is associated with an altered metabolic profile remains unknown.
  
  
  OBJECTIVE
  To characterize CF-TG and determine whether triglycerides (TG) levels are associated with metabolic alterations.
  
  
  METHODS
  210 adult CF subjects from the Montreal Cystic Fibrosis Cohort without known diabetes were included in the analysis. All subjects underwent an OGTT to assess glucose tolerance, insulin secretion (insulin AUC) and insulin sensitivity (Stumvoll index). Fasting lipid profiles, pulmonary function (%FEV1) and BMI were determined. Hypertriglyceridemia (TG>1.7mmol/L) was observed in 20 CF patients. These subjects were matched for age, sex and glucose tolerance category with 20 CF patients (CF-normal-TG) and 20 healthy controls that had TG levels below 1.7mmol/L. Pearson correlations were performed in the complete study sample (n=210) to examine the associations between TG levels and other parameters.
  
  
  RESULTS
  The prevalence of hypertriglyceridemia was 9.5%. Compared to CF-normal-TG, CF-TG subjects displayed significantly higher %FEV1, insulin AUC (AUC0-120, AUC0-30, AUC30-120), cholesterol levels and a higher ratio of total cholesterol to HDL-cholesterol. Pearson analysis demonstrated that TG levels were associated with BMI, %FEV1, fasting insulin, insulin AUC0-120 and AUC30-120, Stumvoll index, cholesterol levels and the ratio of total cholesterol to HDL-cholesterol. All these correlations remained significant after correction for BMI except %FEV1.
  
  
  CONCLUSIONS
  TG levels are associated with a mild alteration of the metabolic profile. Whether these changes will increase the long-term risk of CF patients in developing cardiometabolic complications remains to be investigated.
authors.affiliation: Institut de Recherches Cliniques de Montréal (IRCM), Montréal, Québec, Canada.
authors.forename: Marie-Claire
authors.initials: MC
authors.lastname: Ishimo
authors.forename: Linda
authors.initials: L
authors.lastname: Belson
authors.forename: Sophie
authors.initials: S
authors.lastname: Ziai
authors.forename: Emile
authors.initials: E
authors.lastname: Levy
authors.forename: Yves
authors.initials: Y
authors.lastname: Berthiaume
authors.forename: Lise
authors.initials: L
authors.lastname: Coderre
authors.forename: Rémi
authors.initials: R
authors.lastname: Rabasa-Lhoret
mesh_terms: D000293:Adolescent; D000328:Adult; D003550:Cystic Fibrosis / Q000097:blood* / Q000150:complications*; D005260:Female; D006801:Humans; D015228:Hypertriglyceridemia / Q000097:blood* / Q000150:complications*; D007328:Insulin / Q000097:blood*; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D055815:Young Adult
chemical_list: D007328:Insulin