title: Mathematical modeling of genome replication.
abstract: Eukaryotic DNA replication is initiated from multiple sites on the chromosome, but little is known about the global and local regulation of replication. We present a mathematical model for the spatial dynamics of DNA replication, which offers insight into the kinetics of replication in different types of organisms. Most biological experiments involve average quantities over large cell populations (typically >10(7) cells) and therefore can mask the cell-to-cell variability present in the system. Although the model is formulated in terms of a population of cells, using mathematical analysis we show that one can obtain signatures of stochasticity in individual cells from averaged quantities. This work generalizes the result by Retkute et al. [Phys. Rev. Lett. 107, 068103 (2011)] to a broader set of parameter regimes.
authors.affiliation: Centre for Genetics and Genomics, University of Nottingham, Nottingham NG7 2UH, United Kingdom.
authors.forename: Renata
authors.initials: R
authors.lastname: Retkute
authors.forename: Conrad A
authors.initials: CA
authors.lastname: Nieduszynski
authors.forename: Alessandro
authors.initials: A
authors.lastname: de Moura
mesh_terms: D015825:Chromosomes, Fungal / Q000235:genetics; D004261:DNA Replication / Q000235:genetics*; D004271:DNA, Fungal / Q000096:biosynthesis; D016678:Genome / Q000235:genetics*; D007700:Kinetics; D008957:Models, Genetic; D016011:Normal Distribution; D011336:Probability; D012441:Saccharomyces cerevisiae / Q000235:genetics; D013269:Stochastic Processes
chemical_list: D004271:DNA, Fungal