title: Uneven distribution of NG2 cells in the rat cerebellar vermis and changes in aging.
abstract: We describe by NG2 (neuron-glia chondroitin sulphate proteoglycan 2) immunocytochemistry an uneven distribution of NG2 glial cells in the rat cerebellum, being them more represented in the central lobules of the cerebellar vermis, belonging to the cerebrocerebellum. The cerebellar distribution of NG2 cells changes in aging rats, in which the area where the cells appear to be densely scattered throughout all cerebellar layers involves also more rostral and caudal lobules. In addition, in aging rats, in the most rostral and caudal lobules belonging to the spinocerebellum, punctate reaction product is present at the apical pole of Purkinje cells, i.e. in the area where the majority of synapses between olivary climbing fibers and Purkinje cells occur. Data suggest that the different distribution of NG2 cells is correlated to differences in physiology among cerebellar areas and reflects changes during aging.
authors.affiliation: Dipartimento di Biologia e Biotecnologie Lazzaro Spallanzani, Università di Pavia, via Ferrata 9, Pavia, Italy.
authors.forename: S
authors.initials: S
authors.lastname: Lomoio
authors.forename: D
authors.initials: D
authors.lastname: Necchi
authors.forename: E
authors.initials: E
authors.lastname: Scherini
mesh_terms: D000375:Aging; D000818:Animals; D000941:Antigens / Q000378:metabolism*; D002525:Cerebellar Cortex / Q000166:cytology*; D007150:Immunohistochemistry; D011509:Proteoglycans / Q000378:metabolism*; D051381:Rats; D017207:Rats, Sprague-Dawley; D000099216:Chondroitin Sulfate Proteoglycan 4
chemical_list: D000941:Antigens; D011509:Proteoglycans; D000099216:Chondroitin Sulfate Proteoglycan 4