title: Interplay between Fur and HNS in controlling virulence gene expression in Salmonella typhimurium.
abstract: Salmonella enterica is responsible for a large number of diseases in a wide-range of hosts. Two of the global regulators involved in controlling gene expression during the infection cycle of the bacterium are Fur and HNS. In this paper, we demonstrate computationally that Fur and HNS have disproportionately high density of binding sites in the Pathogenicity Islands on the Salmonella chromosome. Moreover, the frequency of binding sites for the two proteins is correlated throughout the genome of the organism. These results indicate a complex interplay between Fur and HNS in regulating cellular global behavior.
authors.affiliation: Chemical Engineering, Indian Institute of Technology Gandhinagar, VGEC Campus, Chandkheda, Ahmedabad, Gujarat 382424, India.
authors.forename: Mahendra Kumar
authors.initials: MK
authors.lastname: Prajapat
authors.forename: Supreet
authors.initials: S
authors.lastname: Saini
mesh_terms: D001426:Bacterial Proteins / Q000235:genetics* / Q000378:metabolism*; D036781:Fimbriae Proteins / Q000235:genetics / Q000378:metabolism; D010861:Fimbriae, Bacterial / Q000235:genetics / Q000378:metabolism; D005407:Flagella / Q000235:genetics / Q000378:metabolism; D015964:Gene Expression Regulation, Bacterial; D044404:Genomic Islands; D008957:Models, Genetic; D056510:Position-Specific Scoring Matrices; D011485:Protein Binding; D012486:Salmonella typhimurium / Q000235:genetics* / Q000378:metabolism*; D014774:Virulence / Q000235:genetics
chemical_list: D001426:Bacterial Proteins; D036781:Fimbriae Proteins