title: GPR40: a therapeutic target for mediating insulin secretion (review).
abstract: G-protein-coupled receptor 40 (GPR40), known as free fatty acid receptor 1, is mainly expressed in pancreatic β-cells and activated by medium- and long-chain fatty acids. Increasing evidence indicates that the activation of GPR40 in cells causes insulin secretion, and GPR40 has become an attractive therapeutic target for type 2 diabetes. Recently, certain novel GPR40 agonists have been identified that regulate glucose-stimulated insulin secretion, leading to the development of new drugs for the treatment of type 2 diabetes. In this review, we focus on progress in the physiological role of GPR40 and potential drugs targeting GPR40 over the past decade.
authors.affiliation: Guangxi Scientific Experimental Center of Traditional Chinese                     Medicine, Guangxi University of Chinese Medicine, Nanning, P.R. China.
authors.forename: Xiao-Tao
authors.initials: XT
authors.lastname: Feng
authors.forename: Jing
authors.initials: J
authors.lastname: Leng
authors.forename: Zhen
authors.initials: Z
authors.lastname: Xie
authors.forename: Shuang-Lei
authors.initials: SL
authors.lastname: Li
authors.forename: Wei
authors.initials: W
authors.lastname: Zhao
authors.forename: Qian-Li
authors.initials: QL
authors.lastname: Tang
mesh_terms: D000818:Animals; D001572:Benzofurans / Q000494:pharmacology; D001599:Berberine / Q000494:pharmacology; D017322:Clinical Trials, Phase II as Topic; D003924:Diabetes Mellitus, Type 2 / Q000188:drug therapy / Q000378:metabolism; D005230:Fatty Acids, Nonesterified / Q000502:physiology; D006801:Humans; D007004:Hypoglycemic Agents / Q000494:pharmacology; D007328:Insulin / Q000378:metabolism*; D000078790:Insulin Secretion; D008024:Ligands; D058990:Molecular Targeted Therapy; D043562:Receptors, G-Protein-Coupled / Q000819:agonists / Q000502:physiology*; D013450:Sulfones / Q000494:pharmacology
chemical_list: D001572:Benzofurans; C473034:FFAR1 protein, human; D005230:Fatty Acids, Nonesterified; D007004:Hypoglycemic Agents; D007328:Insulin; D008024:Ligands; D043562:Receptors, G-Protein-Coupled; D013450:Sulfones; C557331:TAK-875; D001599:Berberine