title: Is immediate postoperative CA15.3 assay a predictive marker of early postoperative recurrence of carcinoma breast?
abstract: Breast cancer is still an enigma. Systemic metastasis is an important prognostic factor. Tumour marker can predict occult systemic metastasis. To evaluate the immediate postoperative CA15.3 as predictor of early recurrence, a study was carried out in 48 patients of carcinoma breast in whom immediate postoperative marker level was done. In follow-up, recurrence was noted and relation with tumour size and stage done. Null hypothesis and 't' test were used for analysis. Relation of tumour size with marker is weak but strong relation exists between tumour stage with marker and recurrence with marker. CA15.3 predicts tumour load, can also predict occult residual/occult metastatic disease better than other prognostic markers which only predict tumour behaviour.
authors.affiliation: Department of Surgery, IPGME&R and SSKM Hospital, Kolkata 700020.
authors.forename: Diptendra Kumar
authors.initials: DK
authors.lastname: Sarkar
authors.forename: Nilanjan
authors.initials: N
authors.lastname: Panda
authors.forename: Subikas
authors.initials: S
authors.lastname: Biswas
authors.forename: M L
authors.initials: ML
authors.lastname: Saha
authors.forename: A
authors.initials: A
authors.lastname: Majumder
mesh_terms: D014408:Biomarkers, Tumor / Q000032:analysis / Q000378:metabolism; D001943:Breast Neoplasms / Q000378:metabolism / Q000473:pathology / Q000601:surgery; D002277:Carcinoma / Q000378:metabolism / Q000473:pathology / Q000601:surgery; D055088:Early Detection of Cancer / Q000379:methods; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008408:Mastectomy / Q000009:adverse effects / Q000379:methods; D018396:Mucin-1 / Q000032:analysis / Q000378:metabolism; D009362:Neoplasm Metastasis / Q000517:prevention & control*; D009367:Neoplasm Staging / Q000379:methods*; D011183:Postoperative Complications / Q000175:diagnosis / Q000517:prevention & control; D011184:Postoperative Period; D011237:Predictive Value of Tests; D055502:Secondary Prevention
chemical_list: D014408:Biomarkers, Tumor; D018396:Mucin-1