title: Integrative genomics in cardiovascular medicine.
abstract: Integrative genomics studies have greatly advanced our understanding of cardiovascular pathophysiology over the last decade. Here, we highlight the strengths and challenges of this cutting-edge approach and provide examples where novel insights have arisen through the integration of multi-level genomic information and cardiac physiology. Going forward, the integration of comprehensive next-generation sequencing data sets with quantitative phenotypes at the molecular, cellular, and whole-heart level using advanced modelling approaches provides an unprecedented opportunity for cardiovascular science.
authors.affiliation: MRC Clinical Sciences Centre, Imperial Centre for Translational and Experimental Medicine, Imperial College London, Du Cane Road, London, W12 0NN, UK.
authors.forename: James S
authors.initials: JS
authors.lastname: Ware
authors.forename: Enrico
authors.initials: E
authors.lastname: Petretto
authors.forename: Stuart A
authors.initials: SA
authors.lastname: Cook
mesh_terms: D000818:Animals; D002318:Cardiovascular Diseases / Q000235:genetics*; D020869:Gene Expression Profiling; D008040:Genetic Linkage; D014644:Genetic Variation; D023281:Genomics; D006801:Humans; D010641:Phenotype; D040641:Quantitative Trait Loci; D017422:Sequence Analysis, DNA