title: Hormone response in ovarian cancer: time to reconsider as a clinical target?
abstract: Ovarian cancer is the sixth most common cancer worldwide among women in developed countries and the most lethal of all gynecologic malignancies. There is a critical need for the introduction of targeted therapies to improve outcome. Epidemiological evidence suggests a critical role for steroid hormones in ovarian tumorigenesis. There is also increasing evidence from in vitro studies that estrogen, progestin, and androgen regulate proliferation and invasion of epithelial ovarian cancer cells. Limited clinical trials have shown modest response rates; however, they have consistently identified a small subset of patients that respond very well to endocrine therapy with few side effects. We propose that it is timely to perform additional well-designed trials that should include biomarkers of response.
authors.affiliation: Department of Obstetrics, Gynecology and Reproductive Sciences, University of Pittsburgh School of Medicine, Pennsylvania, USA.
authors.forename: Francesmary
authors.initials: F
authors.lastname: Modugno
authors.forename: Robin
authors.initials: R
authors.lastname: Laskey
authors.forename: Ashlee L
authors.initials: AL
authors.lastname: Smith
authors.forename: Courtney L
authors.initials: CL
authors.lastname: Andersen
authors.forename: Paul
authors.initials: P
authors.lastname: Haluska
authors.forename: Steffi
authors.initials: S
authors.lastname: Oesterreich
mesh_terms: D000818:Animals; D018931:Antineoplastic Agents, Hormonal / Q000627:therapeutic use; D000077216:Carcinoma, Ovarian Epithelial; D005260:Female; D006728:Hormones / Q000378:metabolism*; D006801:Humans; D009375:Neoplasms, Glandular and Epithelial / Q000188:drug therapy / Q000453:epidemiology / Q000378:metabolism*; D010051:Ovarian Neoplasms / Q000188:drug therapy / Q000453:epidemiology / Q000378:metabolism*; D011956:Receptors, Cell Surface / Q000378:metabolism
chemical_list: D018931:Antineoplastic Agents, Hormonal; D006728:Hormones; D011956:Receptors, Cell Surface