title: Human ex vivo studies on asexual Plasmodium vivax: the best way forward.
abstract: The lack of a continuous culture method for Plasmodium vivax has given the impression that investigations on this important species are severely curtailed. However, the use of new or improved ex vivo methods and tools to study fresh and thawed isolates from vivax malaria patients is currently providing useful data on P. vivax, such as sensitivity to antimalarial drugs, invasion mechanisms and pathobiology. This review discusses a practical framework for conducting ex vivo studies on the asexual erythrocytic stages of P. vivax and considers the synergies between ex vivo defined phenotypes, ex vivo derived 'omic' studies and in vivo clinical studies.
authors.affiliation: Singapore Immunology Network, Biopolis, Agency for Science Technology and Research, Singapore. micbmr@nus.edu.sg
authors.forename: Bruce
authors.initials: B
authors.lastname: Russell
authors.forename: Rossarin
authors.initials: R
authors.lastname: Suwanarusk
authors.forename: Benoit
authors.initials: B
authors.lastname: Malleret
authors.forename: Fabio T M
authors.initials: FT
authors.lastname: Costa
authors.forename: Georges
authors.initials: G
authors.lastname: Snounou
authors.forename: J
authors.initials: J
authors.lastname: Kevin Baird
authors.forename: François
authors.initials: F
authors.lastname: Nosten
authors.forename: Laurent
authors.initials: L
authors.lastname: Rénia
mesh_terms: D000962:Antimalarials / Q000494:pharmacology*; D018929:Cell Culture Techniques / Q000379:methods*; D004351:Drug Resistance; D006801:Humans; D016780:Malaria, Vivax / Q000469:parasitology* / Q000517:prevention & control; D010966:Plasmodium vivax
chemical_list: D000962:Antimalarials