title: Exogenous surfactant replacement: how to deliver it?
abstract: Exogenous surfactant is a therapeutic option for newborns, children and adults with acute respiratory distress disorders. Although tracheal instillation is still reputed as the classical method of surfactant delivery, alternative techniques have been investigated. Surfactant administration by using thin intra-tracheal catheters, bronchoscopy, laryngeal mask airway, or nebulisation, although variably effective, appear to be less invasive when compared to tracheal intubation. However, further research is still needed to better clarify this matter. (www.actabiomedica.it).
authors.affiliation: Neonatal and Paediatric Intensive Care Unit, Department of Paediatrics, Major City Hospital, Azienda Ospedaliera Universitaria Integrata, Verona, Italy. paolo.biban@ospedaleuniverona.it
authors.forename: Paolo
authors.initials: P
authors.lastname: Biban
authors.forename: Lorenza
authors.initials: L
authors.lastname: Chini
authors.forename: Paolo
authors.initials: P
authors.lastname: Bonetti
authors.forename: Francesco
authors.initials: F
authors.lastname: Sacco
authors.forename: Federico
authors.initials: F
authors.lastname: Zaglia
authors.forename: Pierantonio
authors.initials: P
authors.lastname: Santuz
mesh_terms: D055371:Acute Lung Injury / Q000188:drug therapy*; D000328:Adult; D002648:Child; D016503:Drug Delivery Systems / Q000295:instrumentation* / Q000379:methods*; D006801:Humans; D007231:Infant, Newborn; D007442:Intubation, Intratracheal; D017214:Laryngeal Masks; D009330:Nebulizers and Vaporizers; D011663:Pulmonary Surfactants / Q000008:administration & dosage*; D012127:Respiratory Distress Syndrome, Newborn / Q000188:drug therapy*
chemical_list: D011663:Pulmonary Surfactants