title: Polymorphic variants of DNMT3A and the risk of endometriosis.
abstract: OBJECTIVE
  Overexpression of DNA methyltransferase 3A (DNMT3A) and aberrant methylation of various genes in eutopic endometrium have been demonstrated in women with endometriosis. We aimed to study whether DNMT3A polymorphisms could be a genetic risk factor for endometriosis and endometriosis-related infertility.
  
  
  METHODS
  We studied 5 SNPs (rs2289195, rs7590760, rs13401241, rs749131 and rs1550117) located in the DNMT3A gene in 357 women with endometriosis and 640 controls.
  
  
  RESULTS
  We did not observe significant differences between genotype and allele frequencies of rs2289195, rs7590760, rs13401241, rs749131 and rs1550117 SNPs in women with endometriosis, endometriosis-related infertility, and controls. The lowest p values of the trend test were observed for DNMT3A rs1550117 in endometriosis and endometriosis-related infertility (p(trend)=0.049 and p(trend)=0.055, respectively).
  
  
  CONCLUSIONS
  Our results did not supply evidence for the contribution of SNPs located in DNMT3A to either endometriosis or endometriosis-related infertility.
authors.affiliation: Department of Obstetrics, Gynecology and Gynecological Oncology, Division of Reproduction, Poland.
authors.forename: Malgorzata
authors.initials: M
authors.lastname: Szczepańska
authors.forename: Adrianna
authors.initials: A
authors.lastname: Mostowska
authors.forename: Przemyslaw
authors.initials: P
authors.lastname: Wirstlein
authors.forename: Jacek
authors.initials: J
authors.lastname: Malejczyk
authors.forename: Rafał
authors.initials: R
authors.lastname: Płoski
authors.forename: Jana
authors.initials: J
authors.lastname: Skrzypczak
authors.forename: Paweł P
authors.initials: PP
authors.lastname: Jagodziński
mesh_terms: D000293:Adolescent; D000328:Adult; D016022:Case-Control Studies; D004248:DNA (Cytosine-5-)-Methyltransferases / Q000235:genetics*; D000090205:DNA Methyltransferase 3A; D004715:Endometriosis / Q000150:complications / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D007247:Infertility, Female / Q000209:etiology*; D020641:Polymorphism, Single Nucleotide; D055815:Young Adult
chemical_list: C000717967:DNMT3A protein, human; D004248:DNA (Cytosine-5-)-Methyltransferases; D000090205:DNA Methyltransferase 3A