title: Chronic social stress impairs virus specific adaptive immunity during acute Theiler's virus infection.
abstract: Prior exposure to social disruption (SDR) stress exacerbates Theiler's murine encephalomyelitis virus (TMEV) infection, a model of multiple sclerosis. Here we examined the impact of SDR on T cell responses to TMEV infection in SJL mice. SDR impaired viral clearance and exacerbated acute disease. Moreover, TMEV infection alone increased CD4 and CD8 mRNA expression in brain and spleen while SDR impaired this response. SDR decreased both CD4(+) and CD8(+) virus-specific T cells in CNS, but not spleen. These findings suggest that SDR-induced suppression of virus-specific T cell responses contributes to impairments in viral clearance and exacerbation of acute disease.
authors.affiliation: Department of Psychology, College of Liberal Arts, Texas A&M University, College Station, TX 77843, United States. youngee@pitt.edu
authors.forename: Erin E
authors.initials: EE
authors.lastname: Young
authors.forename: Elisabeth G
authors.initials: EG
authors.lastname: Vichaya
authors.forename: Nicole M
authors.initials: NM
authors.lastname: Reusser
authors.forename: Jennifer L
authors.initials: JL
authors.lastname: Cook
authors.forename: Andrew J
authors.initials: AJ
authors.lastname: Steelman
authors.forename: C Jane R
authors.initials: CJ
authors.lastname: Welsh
authors.forename: Mary W
authors.initials: MW
authors.lastname: Meagher
mesh_terms: D000208:Acute Disease; D056704:Adaptive Immunity / Q000502:physiology*; D000818:Animals; D001921:Brain / Q000276:immunology / Q000378:metabolism / Q000821:virology; D015704:CD4 Antigens / Q000235:genetics / Q000378:metabolism; D015496:CD4-Positive T-Lymphocytes / Q000473:pathology; D016827:CD8 Antigens / Q000235:genetics / Q000378:metabolism; D018414:CD8-Positive T-Lymphocytes / Q000473:pathology; D018188:Cardiovirus Infections / Q000276:immunology* / Q000503:physiopathology*; D004195:Disease Models, Animal; D015967:Gene Expression Regulation, Viral / Q000502:physiology; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D011051:Poliomyelitis / Q000276:immunology* / Q000503:physiopathology*; D012333:RNA, Messenger / Q000378:metabolism; D013154:Spleen / Q000276:immunology / Q000378:metabolism / Q000821:virology; D013315:Stress, Psychological / Q000276:immunology / Q000503:physiopathology*; D017945:Theilovirus / Q000472:pathogenicity
chemical_list: D015704:CD4 Antigens; D016827:CD8 Antigens; D012333:RNA, Messenger