title: Increased Rab25 expression is not correlated with peritoneal metastasis of ovarian cancers.
abstract: Ovarian cancer is the leading cause of death in gynecological cancer. Studies suggested Rab25 is involved in the pathogenesis of ovarian cancers. We here investigated the expression of Rab25 is in all ovarian cancers and whether the expression of Rab25 is associated with peritoneal metastasis. Fifty-nine ovarian cancer patients were included and the levels of Rab25 measured by immunohistochemistry. Our data showed Rab25 was highly expressed in all subtypes of epithelial ovarian cancers, and two subtypes of germ cell tumors, but not in sex cord stromal tumors. Furthermore, the Rab25 expression was not correlated with peritoneal metastasis of ovarian cancer.
authors.affiliation: Wuxi Maternity and Children Health Hospital Affiliated Nanjing Medical University, China.
authors.forename: Min
authors.initials: M
authors.lastname: Zhao
authors.forename: Yong Xiang
authors.initials: YX
authors.lastname: Yin
authors.forename: Fang
authors.initials: F
authors.lastname: Guo
authors.forename: You Yi
authors.initials: YY
authors.lastname: Yang
authors.forename: Fang
authors.initials: F
authors.lastname: Shen
authors.forename: Qi
authors.initials: Q
authors.lastname: Chen
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D014408:Biomarkers, Tumor; D000077216:Carcinoma, Ovarian Epithelial; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008875:Middle Aged; D009375:Neoplasms, Glandular and Epithelial / Q000378:metabolism*; D010051:Ovarian Neoplasms / Q000378:metabolism*; D010534:Peritoneal Neoplasms / Q000378:metabolism / Q000556:secondary*; D018312:Sex Cord-Gonadal Stromal Tumors / Q000378:metabolism / Q000556:secondary*; D055815:Young Adult; D020691:rab GTP-Binding Proteins / Q000378:metabolism*
chemical_list: D014408:Biomarkers, Tumor; C509763:Rab25 protein, human; D020691:rab GTP-Binding Proteins