title: Ultrasensitive and facile electrochemical deoxyribonucleic acid biosensor based on the conformational change of the recognition interface.
abstract: An ultrasensitive electrochemical impedance spectroscopic deoxyribonucleic acid biosensor has been developed based on the conformational change of the deoxyribonucleic acid recognition interface with lodging probes. Pairing process leads to desorption of deoxyribonucleic acid bases from the gold surface, leading to a significant change of the interfacial conformation and the charge transfer resistance. Remarkably low detection limits down to 40 fM are thus obtained without any additional amplification step.
authors.affiliation: Department of Pharmaceutical Analysis, Fujian Medical University, Fuzhou 350004, China. chenandhu@163.com
authors.forename: Wei
authors.initials: W
authors.lastname: Chen
authors.forename: Yin-Huan
authors.initials: YH
authors.lastname: Liu
authors.forename: Hong-Na
authors.initials: HN
authors.lastname: Li
authors.forename: Ai-Lin
authors.initials: AL
authors.lastname: Liu
authors.forename: Xin-Hua
authors.initials: XH
authors.lastname: Lin
authors.forename: Yuan-Zhong
authors.initials: YZ
authors.lastname: Chen
mesh_terms: D015374:Biosensing Techniques; D004247:DNA / Q000737:chemistry*; D058266:Dielectric Spectroscopy; D055664:Electrochemical Techniques; D057230:Limit of Detection; D008958:Models, Molecular; D008968:Molecular Conformation
chemical_list: D004247:DNA