title: Stem cells and modeling of autism spectrum disorders.
abstract: Human neurons, generated from reprogrammed somatic cells isolated from live patients, bring a new perspective on the understanding of Autism Spectrum Disorders (ASD). The new technology can nicely complement other models for basic research and the development of therapeutic compounds aiming to revert or ameliorate the condition. Here, we discuss recent advances on the use of stem cells and other models to study ASDs, as well as their limitations, implications and future perspectives.
authors.affiliation: University of California San Diego, School of Medicine, Department of Pediatrics/Rady Children's Hospital San Diego, Department of Cellular & Molecular Medicine, Stem Cell Program, La Jolla, CA 92093, MC 0695, USA.
authors.forename: Beatriz C G
authors.initials: BC
authors.lastname: Freitas
authors.affiliation: University of California San Diego, School of Medicine, Department of Pediatrics/Rady Children's Hospital San Diego, Department of Cellular & Molecular Medicine, Stem Cell Program, La Jolla, CA 92093, MC 0695, USA.
authors.forename: Cleber A
authors.initials: CA
authors.lastname: Trujillo
authors.affiliation: University of California San Diego, School of Medicine, Department of Pediatrics/Rady Children's Hospital San Diego, Department of Cellular & Molecular Medicine, Stem Cell Program, La Jolla, CA 92093, MC 0695, USA.
authors.forename: Cassiano
authors.initials: C
authors.lastname: Carromeu
authors.affiliation: University of California San Diego, School of Medicine, Department of Pediatrics/Rady Children's Hospital San Diego, Department of Cellular & Molecular Medicine, Stem Cell Program, La Jolla, CA 92093, MC 0695, USA.
authors.forename: Marianna
authors.initials: M
authors.lastname: Yusupova
authors.affiliation: University of California San Diego, School of Medicine, Department of Pediatrics/Rady Children's Hospital San Diego, Department of Cellular & Molecular Medicine, Stem Cell Program, La Jolla, CA 92093, MC 0695, USA.
authors.forename: Roberto H
authors.initials: RH
authors.lastname: Herai
authors.affiliation: University of California San Diego, School of Medicine, Department of Pediatrics/Rady Children's Hospital San Diego, Department of Cellular & Molecular Medicine, Stem Cell Program, La Jolla, CA 92093, MC 0695, USA. Electronic address: muotri@ucsd.edu.
authors.forename: Alysson R
authors.initials: AR
authors.lastname: Muotri
mesh_terms: D000818:Animals; D064987:Cell- and Tissue-Based Therapy / Q000379:methods; D002659:Child Development Disorders, Pervasive / Q000235:genetics / Q000628:therapy*; D004195:Disease Models, Animal; D006801:Humans; D009474:Neurons / Q000166:cytology* / Q000502:physiology; D015518:Rett Syndrome / Q000235:genetics / Q000628:therapy*; D013234:Stem Cells / Q000166:cytology*