title: [SAMHD1 − a HIV-1 restriction factor derived from Myeloid lineage monocytes].
abstract: HIV-1 restriction factors have became one of the hottest fields of AIDS researches. In 2011, SAMHD1 was demonstrated to be a novel HIV-1 restriction factor, adding to a list of HIV-1 restriction factors that include APOBEC3G, TRIM5α and Tetherin. SAMHD1 is highly expressed in myeloid-lineage monocytes, such as macrophages and dendritic cells. In this paper, we review the current research progress on the structure of SAMHD1, its antiviral mechanism, interaction with the lentivirus Vpx, and evolution. The identification of SAMHD1 opens the door towards understanding the role of SAMHD1 in lentiviral pathogenesis.
authors.affiliation: Institute of Life Sciences, Jiangsu University, China.
authors.forename: Pei-Lu
authors.initials: PL
authors.lastname: Li
authors.forename: Qian-Qian
authors.initials: QQ
authors.lastname: Chen
authors.forename: Chi-Yu
authors.initials: CY
authors.lastname: Zhang
mesh_terms: D000818:Animals; D015658:HIV Infections / Q000235:genetics / Q000276:immunology* / Q000821:virology; D015497:HIV-1 / Q000502:physiology*; D006801:Humans; D009000:Monocytes / Q000276:immunology* / Q000821:virology; D020559:Monomeric GTP-Binding Proteins / Q000235:genetics / Q000276:immunology*; D000076106:SAM Domain and HD Domain-Containing Protein 1; D014779:Virus Replication
chemical_list: D000076106:SAM Domain and HD Domain-Containing Protein 1; C484280:SAMHD1 protein, human; D020559:Monomeric GTP-Binding Proteins