title: [Otosclerosis- <<the mysterious sphinx>> or the loss of the natural variant of inertness (<<bradytrophicity>> of the labyrinth capsule)].
abstract: The author suggests an original hypothesis of otosclerosis based on the analyses of the literature publications for many years and his personal clinical observations. The normal labyrinth capsule is considered to be bradytrophic, i.e. inert and showing an extremely low level of metabolic processes. The disturbance of bradytrophicity under the action of individual factors and/or especially their combination make it involved in the maintenance of calcium homeostasis in the body. The validity of this conjecture is confirmed by the results of histological investigations, viz. the appearance of diquide or xplasma-like, bone in the labyrinth of the patients suffering otosclerosis. Such bone resorption is known to occur in other parts of the bony skeletontoo and should be regarded as a normal physiological process contributing to the replenishment of blood calcium deficiency.The subsequent reorganization (remodeling) of any part of the bony skeleton is physiologically neutral. In the labyrinth capsule,with its small size and delicate structure, such reorganization induces the otosclerotic process responsible for dysfunction of the membranaceous labyrinth. The surgical treatment of the patients presenting with otosclerosis should be supplemented by conservative treatment intended to slow down the otosclerotic reorganization and to restore bradytrophicity of the labyrinth capsule.
authors.forename: A S
authors.initials: AS
authors.lastname: Kiselev
mesh_terms: D016723:Bone Remodeling / Q000502:physiology; D002118:Calcium / Q000378:metabolism; D019468:Disease Management; D007758:Ear, Inner / Q000378:metabolism / Q000473:pathology / Q000503:physiopathology; D006706:Homeostasis / Q000502:physiology; D006801:Humans; D008660:Metabolism; D009929:Organ Size; D010040:Otosclerosis / Q000209:etiology / Q000378:metabolism / Q000473:pathology / Q000503:physiopathology / Q000628:therapy
chemical_list: D002118:Calcium