title: Caveolin 1 expression correlates with poor prognosis and focal adhesion kinase expression in gastric cancer.
abstract: OBJECTIVE
  Caveolin 1 gene is known as a tumor promoter or suppressor, depending on the tumor type and/or tumor stage. We aimed to investigate the clinical significance of caveolin 1 protein (Cav1) expression in gastric cancer (GC).
  
  
  METHODS
  Immunohistochemistry was performed on tissue array slides containing 405 GC specimens. The relationships between Cav1 expression and clinicopathological factors, prognosis, focal adhesion kinase expression, mucin phenotypes and p53 expression were analyzed.
  
  
  RESULTS
  In non-neoplastic gastric mucosa, Cav1 was not expressed in the epithelial compartment. In GC, positive staining of Cav1 was shown in 22 (5.4%) of 405 cases and was significantly higher in the advanced GC group than in the early GC group (p = 0.037). Also, it was significantly associated with advanced pTNM stage (p = 0.027) and lymph node metastasis (p = 0.018). Moreover, survival analysis showed that Cav1 expression was an independent prognostic factor of poor survival (p = 0.028). In addition, the expression of Cav1 was positively correlated with that of focal adhesion kinase (p = 0.034).
  
  
  CONCLUSIONS
  These results indicate that the expression of Cav1 is significantly correlated with cancer progression and poor prognosis in GC. Thus, Cav1 could supplement its protein expression for the diagnosis and treatment of GC.
authors.affiliation: Department of Pathology, Seoul National University College of Medicine, Jongno-gu, Seoul, Korea.
authors.forename: Kyung Han
authors.initials: KH
authors.lastname: Nam
authors.forename: Byung Lan
authors.initials: BL
authors.lastname: Lee
authors.forename: Joo Hyun
authors.initials: JH
authors.lastname: Park
authors.forename: Jin
authors.initials: J
authors.lastname: Kim
authors.forename: Nayoung
authors.initials: N
authors.lastname: Han
authors.forename: Hee Eun
authors.initials: HE
authors.lastname: Lee
authors.forename: Min A
authors.initials: MA
authors.lastname: Kim
authors.forename: Hye Seung
authors.initials: HS
authors.lastname: Lee
authors.forename: Woo Ho
authors.initials: WH
authors.lastname: Kim
mesh_terms: D000368:Aged; D002277:Carcinoma / Q000378:metabolism* / Q000401:mortality / Q000473:pathology / Q000601:surgery; D051242:Caveolin 1 / Q000378:metabolism*; D045744:Cell Line, Tumor; D018450:Disease Progression; D005260:Female; D051416:Focal Adhesion Protein-Tyrosine Kinases / Q000378:metabolism*; D015971:Gene Expression Regulation, Enzymologic; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D007150:Immunohistochemistry; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D009077:Mucins / Q000378:metabolism; D015999:Multivariate Analysis; D009367:Neoplasm Staging; D010641:Phenotype; D011379:Prognosis; D056910:Republic of Korea; D013274:Stomach Neoplasms / Q000378:metabolism* / Q000401:mortality / Q000473:pathology / Q000601:surgery; D016019:Survival Analysis; D046888:Tissue Array Analysis; D016159:Tumor Suppressor Protein p53 / Q000378:metabolism
chemical_list: D051242:Caveolin 1; D009077:Mucins; D016159:Tumor Suppressor Protein p53; D051416:Focal Adhesion Protein-Tyrosine Kinases