title: Superoxide scavenging and antimicrobial activities of novel transition metal complexes of oxydiacetate dianion as primary ligand: spectral characterization, cyclic voltammetric investigations and crystal structure.
abstract: Complexes of stoichiometries [M(oda)(4-pic)H(2)O]·xH(2)O [M = Cu(1), x = 2; Co (2), x = 4; Ni (3), x = 2; ] [Fe(oda)(4-pic)]·Cl (4) and {[Cu(2-pa)(2)]·2H(2)O}(n) (5) (H(2)oda = oxydiacetic acid, 4-pic = 4-picoline and 2-paH = 2-picolinic acid) were prepared to explore their uses as possible models for mono- and poly-nuclear metallo-pharmaceuticals. The chemical structures were elucidated by IR, FAB-Mass, (1)H, (13)C NMR, EPR and UV-visible (ligand field) spectral analyses. Electrochemical investigations are consistent with formation of stable quasi-reversible redox Co(II/III) and Cu(II/III) couples in the solution. Single crystal X-ray data of the complex (5) indicated a 1D coordination polymeric structure with extensive H-bonding to form supramolecular frameworks. The antimicrobial activities were examined against Escherichia coli (k-12), Bacillus subtilis (MTC-121), Staphylococcus aureus (IOASA-22), Salmonella typhimurium (MTCC-98), Candida albicans, Aspergillus fumigatus and Penicillium marneffei. The superoxide dismutase (SOD) activities of the Cu(II) complexes (1 and 5) were assessed employing nitrobluetetrazolium (NBT) assay.
authors.affiliation: Coordination Chemistry Research Group, Department of Chemistry, Aligarh Muslim University, Aligarh 202002, India. zafarasiddiqi@yahoo.co.in
authors.forename: Zafar A
authors.initials: ZA
authors.lastname: Siddiqi
authors.forename: Prashant K
authors.initials: PK
authors.lastname: Sharma
authors.forename: M
authors.initials: M
authors.lastname: Shahid
authors.forename: Mohd
authors.initials: M
authors.lastname: Khalid
authors.lastname: Anjuli
authors.forename: Armeen
authors.initials: A
authors.lastname: Siddique
authors.forename: Sarvendra
authors.initials: S
authors.lastname: Kumar
mesh_terms: D000085:Acetates / Q000737:chemistry*; D000890:Anti-Infective Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects / Q000254:growth & development; D056831:Coordination Complexes / Q000138:chemical synthesis* / Q000494:pharmacology; D018360:Crystallography, X-Ray; D055664:Electrochemical Techniques; D005658:Fungi / Q000187:drug effects / Q000254:growth & development; D006860:Hydrogen Bonding; D009682:Magnetic Resonance Spectroscopy; D019216:Metals, Heavy / Q000737:chemistry*; D050296:Microbial Viability / Q000187:drug effects; D015394:Molecular Structure; D009580:Nitroblue Tetrazolium; D010847:Picolines / Q000737:chemistry*; D010848:Picolinic Acids / Q000737:chemistry*; D013055:Spectrophotometry, Infrared; D013482:Superoxide Dismutase / Q000737:chemistry; D013481:Superoxides / Q000037:antagonists & inhibitors*
chemical_list: D000085:Acetates; D000890:Anti-Infective Agents; D056831:Coordination Complexes; D019216:Metals, Heavy; D010847:Picolines; D010848:Picolinic Acids; D013481:Superoxides; D009580:Nitroblue Tetrazolium; D013482:Superoxide Dismutase; C030614:picolinic acid