title: The influence of simvastatin in rats mandible and femur bone mass under Freund's adjuvant arthritis.
abstract: OBJECTIVES. Complete Freund's Adjuvant (CFA)-induced arthritis in rats has been used widely as a model of rodent arthropathy and polyarthritis followed by osteoporosis, decreased bone formation and increased bone formation. Osteoporosis is characterized by rapid reduce of bone mass affecting more than 100 million people worldwide. Periodontitis a chronic inflammatory, of multifactorian origin disease has been associated with general osteoporosis. Protective bone-specific anabolic and antiresorptive effects of HMG-CoA reductase inhibitors have also been evaluated in normal and osteoporotic bone. AIM. The aim of the study was to investigate mandible and femur bone density in Freund's adjuvant induced arthritis rats under the influence of simvastatin. METHODS. Three groups (A, B, C) of 7 Wistar male rats each aged 3 months, (292±48.38 g) were used. A control. Group B and C subjected experimental arthritis via complete Freund's adjuvant injected in right paw. Group C was treated with simvastatin 0.5 mg/kg/daily po 14 days. Femur, mandible were isolated and sizes parameters, biochemical serum findings and BMD were estimated. RESULTS. CFA established by paw diameter, adrenals and spleen weight increase and thymus weight decrease, while biochemical serum findings were also affected. Reduced femur, mandible weight and general bone mass parameters BMD evaluated via DEXA occurred and restored under simvastatin treatment. CONCLUSIONS. CFA induced mandible and femur injuries are repaired by ssimvatatin treatment that could be therapeutically useful.
authors.affiliation: Department of Pharmacology Medical School, University of Athens, Greece.
authors.forename: Nikos
authors.initials: N
authors.lastname: Seferos
authors.forename: Alkistis
authors.initials: A
authors.lastname: Pantopoulou
authors.forename: Antonia
authors.initials: A
authors.lastname: Kotsiou
authors.forename: Georgios
authors.initials: G
authors.lastname: Rallis
authors.forename: Christine
authors.initials: C
authors.lastname: Tesseromatis
mesh_terms: D015502:Absorptiometry, Photon; D000818:Animals; D001169:Arthritis, Experimental / Q000139:chemically induced / Q000188:drug therapy*; D015519:Bone Density / Q000187:drug effects*; D005269:Femur / Q000187:drug effects*; D005620:Freund's Adjuvant / Q000009:adverse effects; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000494:pharmacology / Q000627:therapeutic use*; D008297:Male; D008334:Mandible / Q000187:drug effects*; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar; D019821:Simvastatin / Q000494:pharmacology / Q000627:therapeutic use*
chemical_list: D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D005620:Freund's Adjuvant; D019821:Simvastatin