title: Diastereoselective multicomponent reaction in water: synthesis of 2-azapyrrolizidine alkaloid analogues.
abstract: Synthesis of the 2-aza analogues of the pyrrolizidine alkaloid motif with two contiguous stereocenters has been achieved with high regio-, chemo-, and diastereoselectivity by an innovative multicomponent reaction in water. This elegant tactic has integrated the principles of privileged substructure-based Diversity Oriented Synthesis (pDOS) and Biology Oriented Synthesis (BIOS) to access a biologically relevant scaffold.
authors.affiliation: Department of Chemistry, Pondicherry University, Puducherry 605 014, India.
authors.forename: Balakrishnan
authors.initials: B
authors.lastname: Rajarathinam
authors.forename: Gnanasambandam
authors.initials: G
authors.lastname: Vasuki
mesh_terms: D001372:Aza Compounds / Q000138:chemical synthesis*; D008958:Models, Molecular; D015394:Molecular Structure; D011763:Pyrrolizidine Alkaloids / Q000138:chemical synthesis*; D013237:Stereoisomerism; D014867:Water / Q000737:chemistry
chemical_list: D001372:Aza Compounds; D011763:Pyrrolizidine Alkaloids; D014867:Water