title: The complex regulation of TGF-β in cardiovascular disease.
abstract: Transforming growth factor β (TGF-β1) is a pleiotropic cytokine with many and complex effects in cell and tissue physiology. This is made possible by a very complex and interwoven signaling system, whose regulation continues to be the focus of a growing line of research. This complex regulation translates to a key role in cardiovascular physiology, hemostasis, and the blood-vessel interface. In accordance with this, the TGF-β1 pathway appears to be deregulated in related disorders, such as atherosclerotic vascular disease and myeloproliferative syndromes. It is expected that the growing amount of experimental and clinical research will yield medical advances in the applications of knowledge of the TGF-β1 pathway to diagnosis and therapeutics.
authors.affiliation: Department of Pharmacology, School of Medicine, Universidad Complutense, Madrid, Spain. santiredondo@hotmail.com
authors.forename: Santiago
authors.initials: S
authors.lastname: Redondo
authors.forename: Jorge
authors.initials: J
authors.lastname: Navarro-Dorado
authors.forename: Marta
authors.initials: M
authors.lastname: Ramajo
authors.forename: Úrsula
authors.initials: Ú
authors.lastname: Medina
authors.forename: Teresa
authors.initials: T
authors.lastname: Tejerina
mesh_terms: D000818:Animals; D002318:Cardiovascular Diseases / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D002319:Cardiovascular System / Q000378:metabolism* / Q000473:pathology; D005786:Gene Expression Regulation; D006801:Humans; D018125:Receptors, Transforming Growth Factor beta / Q000378:metabolism; D015398:Signal Transduction; D053773:Transforming Growth Factor beta1 / Q000235:genetics / Q000378:metabolism*
chemical_list: D018125:Receptors, Transforming Growth Factor beta; D053773:Transforming Growth Factor beta1