title: Dengue: profile of hematological and biochemical dynamics.
abstract: OBJECTIVE
  The objective of this study was to correlate laboratory tests during the evolution of dengue fever, comparing frequencies between the different clinical forms in order to use test results to predict the severity of the disease.
  
  
  METHODS
  This is an observational, descriptive and retrospective study of 154 patients with clinical and serological diagnoses of dengue fever who, in the period from January to May 2008, were admitted in a tertiary state hospital in the city of Fortaleza that is a referral center for infectious diseases. The patients were allocated to two groups according to age: under 15 years old (n = 66) and 15 years or older (n = 88). The tests analyzed were blood count, platelet count, and serum aspartate aminotransferase (AST) and alanine aminotransferase (ALT) concentrations.
  
  
  RESULTS
  Thrombocytopenia and elevated transaminases were observed in patients with classic dengue fever. The main laboratory abnormalities found in dengue hemorrhagic fever were thrombocytopenia, hemoconcentration and elevated transaminases, similar to severe dengue with the exception of hemoconcentration. Most laboratory abnormalities started on the 3rd day but were more evident on the 5th day with restoration of values by the 11(th) day; this was more prominent in under 15-year-olds and with the more severe clinical forms.
  
  
  CONCLUSIONS
  These results are relevant in assessing the disease because they can be used as markers for more severe forms and can help by enabling the adaptation of the therapeutic conduct to the needs of individual patients.
authors.affiliation: Department of Pathology and Forensic Medicine, Universidade Federal do Ceará - UFC, Fortaleza, CE, Brazil.
authors.forename: Francisca Raimunda F Guerreiro
authors.initials: FR
authors.lastname: Azin
authors.forename: Romelia Pinheiro
authors.initials: RP
authors.lastname: Gonçalves
authors.forename: Maria Helena da Silva
authors.initials: MH
authors.lastname: Pitombeira
authors.forename: Danielle Malta
authors.initials: DM
authors.lastname: Lima
authors.forename: Ivo Castelo
authors.initials: IC
authors.lastname: Branco