title: Genetic variation at the synaptic vesicle gene SV2A is associated with schizophrenia.
abstract: Convergent evidence from pharmacological and animal studies suggests a possible role for the synaptic vesicle glycoprotein 2A gene (SV2A) in schizophrenia susceptibility. To test systematically all common variants in the SV2A gene region for an association with schizophrenia, we used a HapMap-based haplotype tagging approach and tested five SNPs in 794 patients and 843 controls. The SNP rs15931 showed evidence for an association with schizophrenia and was followed-up in an independent sample of 2581 individuals (overall p-value=0.0042, OR=0.779). Our study in the German population provides evidence, at a genetic level, for the involvement of the SV2A gene region in schizophrenia.
authors.affiliation: Department of Genomics, Life & Brain Center, University of Bonn, Bonn, Germany.
authors.forename: Manuel
authors.initials: M
authors.lastname: Mattheisen
authors.forename: Thomas W
authors.initials: TW
authors.lastname: Mühleisen
authors.forename: Jana
authors.initials: J
authors.lastname: Strohmaier
authors.forename: Jens
authors.initials: J
authors.lastname: Treutlein
authors.forename: Igor
authors.initials: I
authors.lastname: Nenadic
authors.forename: Margrieta
authors.initials: M
authors.lastname: Alblas
authors.forename: Sandra
authors.initials: S
authors.lastname: Meier
authors.forename: Franziska
authors.initials: F
authors.lastname: Degenhardt
authors.forename: Stefan
authors.initials: S
authors.lastname: Herms
authors.forename: Per
authors.initials: P
authors.lastname: Hoffmann
authors.forename: Stephanie H
authors.initials: SH
authors.lastname: Witt
authors.forename: Ina
authors.initials: I
authors.lastname: Giegling
authors.forename: Heinrich
authors.initials: H
authors.lastname: Sauer
authors.forename: Thomas G
authors.initials: TG
authors.lastname: Schulze
authors.forename: Dan
authors.initials: D
authors.lastname: Rujescu
authors.forename: Markus M
authors.initials: MM
authors.lastname: Nöthen
authors.forename: Marcella
authors.initials: M
authors.lastname: Rietschel
authors.forename: Sven
authors.initials: S
authors.lastname: Cichon
mesh_terms: D000328:Adult; D005260:Female; D005500:Follow-Up Studies; D005787:Gene Frequency; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D005838:Genotype; D005858:Germany; D006801:Humans; D015810:Linkage Disequilibrium; D008297:Male; D008562:Membrane Glycoproteins / Q000235:genetics*; D008875:Middle Aged; D009419:Nerve Tissue Proteins / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D012559:Schizophrenia / Q000235:genetics*
chemical_list: D008562:Membrane Glycoproteins; D009419:Nerve Tissue Proteins; C076414:SV2A protein, human