title: Dynamic changes in serum monocyte chemoattractant protein-1, and regulated upon activation, normal T cell expressed and secreted levels in patients with minor intracerebral hemorrhage.
abstract: OBJECTIVE
  To investigate the time expression profile of serum monocyte chemoattractant protein (MCP)-1, and regulated upon activation, normal T cell expressed and secreted (RANTES) after minor intracerebral hemorrhage (ICH).
  
  
  METHODS
  This study was carried out in the Department of Neurology in the Fifth Affiliated Hospital of Sun Yat-Sen University, Zhuhai, China. Fifteen consecutive hospitalized patients with minor ICH were enrolled from July 2008 to December 2008. The patients` serum levels of MCP-1 and RANTES were measured by enzyme-linked immunosorbent assay (ELISA) on days 1-3, 7, 14, and 30 after the onset of ICH, and compared with that of 10 controls.
  
  
  RESULTS
  The serum MCP-1 levels increased immediately on days 1-3 (p=0.000) after onset, and then decreased slightly on day 7 (p=0.001), and day 14 (p=0.000); after day 14, the levels continued to increase and reached their highest levels on day 30 (p=0.000). No statistical differences in MCP-1 levels were found between any time points. The RANTES levels at any time point did not differ significantly from the controls. The levels of MCP-1 and RANTES were not correlated with the serum C-reactive protein (CRP) levels, brain hematoma volumes, acute neurologic impairment, or 3-month outcome.
  
  
  CONCLUSIONS
  The persistent elevation of serum MCP-1 levels after minor ICH may contribute to the acute damage and the repair following an ICH.
authors.affiliation: Department of Neurology, the Fifth Affiliated Hospital of Sun Yat-Sen University, Zhuhai, Guangdong Province, China. lizdsysu@163.com
authors.forename: Zhendong
authors.initials: Z
authors.lastname: Li
authors.forename: Shijian
authors.initials: S
authors.lastname: Luo
authors.forename: Yuhua
authors.initials: Y
authors.lastname: Fan
authors.forename: Huabin
authors.initials: H
authors.lastname: Sun
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D002097:C-Reactive Protein / Q000378:metabolism; D002543:Cerebral Hemorrhage / Q000097:blood* / Q000150:complications / Q000473:pathology*; D018932:Chemokine CCL2 / Q000097:blood*; D018946:Chemokine CCL5 / Q000097:blood*; D016001:Confidence Intervals; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009422:Nervous System Diseases / Q000209:etiology; D012189:Retrospective Studies; D012720:Severity of Illness Index; D018709:Statistics, Nonparametric; D013997:Time Factors; D055815:Young Adult
chemical_list: D018932:Chemokine CCL2; D018946:Chemokine CCL5; D002097:C-Reactive Protein