title: Silicon nanowire biosensor and its applications in disease diagnostics: a review.
abstract: Over the past decade, silicon nanowire (SiNW) biosensors have been studied for the detection of biological molecules as highly sensitive, label-free, and electrical tools. Herein we present a comprehensive review about the fabrication of SiNW biosensors and their applications in disease diagnostics. We discuss the detection of important biomarkers related to diseases including cancer, cardiovascular diseases, and infectious diseases. SiNW biosensors hold great promise to realize point-of-care (POC) devices for disease diagnostics with potential for miniaturization and integration.
authors.affiliation: School of Laboratory Medicine, Hubei University of Chinese Medicine, 1 Huangjia Lake West Road, Wuhan 430065, China. zhanggj@hbtcm.edu.cn
authors.forename: Guo-Jun
authors.initials: GJ
authors.lastname: Zhang
authors.forename: Yong
authors.initials: Y
authors.lastname: Ning
mesh_terms: D014408:Biomarkers, Tumor / Q000097:blood; D015374:Biosensing Techniques; D002318:Cardiovascular Diseases / Q000175:diagnosis / Q000378:metabolism; D003141:Communicable Diseases / Q000175:diagnosis / Q000378:metabolism / Q000821:virology; D019719:Diagnostic Equipment; D006801:Humans; D053118:Influenza A Virus, H1N1 Subtype / Q000302:isolation & purification; D035683:MicroRNAs / Q000378:metabolism; D053770:Nanowires / Q000737:chemistry*; D009369:Neoplasms / Q000175:diagnosis / Q000378:metabolism; D012825:Silicon / Q000737:chemistry*; D020107:Troponin T / Q000378:metabolism
chemical_list: D014408:Biomarkers, Tumor; D035683:MicroRNAs; D020107:Troponin T; D012825:Silicon