title: Staphylococcus aureus CC398 clade associated with human-to-human transmission.
abstract: Staphylococcus aureus clonal complex 398 (CC398) isolates colonize livestock and can spread to human contacts. Genetic analysis of isolates epidemiologically associated with human-to-human, but not livestock, transmission in multiple countries and continents identified a common clade that was negative for tet(M) and positive for bacteriophage 3. Another group of human-to-human-transmitted isolates belonged to the common livestock-associated clade but had acquired a unique 7 bacteriophage.
authors.affiliation: Infection and Immunity, Division of Clinical Science, St George's University of London, London, United Kingdom.
authors.forename: Alex J
authors.initials: AJ
authors.lastname: McCarthy
authors.forename: Willem
authors.initials: W
authors.lastname: van Wamel
authors.forename: Stien
authors.initials: S
authors.lastname: Vandendriessche
authors.forename: Jesper
authors.initials: J
authors.lastname: Larsen
authors.forename: Olivier
authors.initials: O
authors.lastname: Denis
authors.forename: Cristina
authors.initials: C
authors.lastname: Garcia-Graells
authors.forename: Ann-Catrin
authors.initials: AC
authors.lastname: Uhlemann
authors.forename: Franklin D
authors.initials: FD
authors.lastname: Lowy
authors.forename: Robert
authors.initials: R
authors.lastname: Skov
authors.forename: Jodi A
authors.initials: JA
authors.lastname: Lindsay
mesh_terms: D000818:Animals; D001426:Bacterial Proteins / Q000235:genetics; D001435:Bacteriophages / Q000235:genetics; D016000:Cluster Analysis; D004269:DNA, Bacterial / Q000235:genetics; D006801:Humans; D046228:Microarray Analysis; D013203:Staphylococcal Infections / Q000382:microbiology* / Q000635:transmission* / Q000662:veterinary; D013211:Staphylococcus aureus / Q000145:classification / Q000235:genetics / Q000472:pathogenicity* / Q000821:virology; D013552:Swine
chemical_list: D001426:Bacterial Proteins; D004269:DNA, Bacterial; C083138:Tet M resistance protein, Bacteria