title: [Ototoxicity of cisplatin].
abstract: The objective of this publication is to summarize "classical" and modern concepts of pathogenesis, clinical features of cisplatin ototoxicity, its screening, and prophylaxis. It is argued that pathogenesis of a cisplatin-induced injury to the inner ear shares common features with the ototoxic mechanisms of action of other pharmaceuticals even though it is characterized by certain important differences. The authors consider the mechanisms of ototropicity, specific cytochemical aspects of cisplatin cytotoxicity that aggravate risk factors, and genetic predisposition to the development of iatrogenic problems. The data are presented on monitoring and experimental aspects of otoprotection for the prevention of cisplatin-induced damage to the auditory analyzer.
authors.forename: S A
authors.initials: SA
authors.lastname: Ivanov
authors.forename: S G
authors.initials: SG
authors.lastname: Zhuravskiĭ
authors.forename: M M
authors.initials: MM
authors.lastname: Galagudza
mesh_terms: D000367:Age Factors; D000970:Antineoplastic Agents / Q000009:adverse effects / Q000493:pharmacokinetics; D002945:Cisplatin / Q000009:adverse effects / Q000493:pharmacokinetics; D004305:Dose-Response Relationship, Drug; D004333:Drug Administration Routes; D006319:Hearing Loss, Sensorineural / Q000139:chemically induced / Q000175:diagnosis / Q000235:genetics / Q000503:physiopathology; D006320:Hearing Tests / Q000379:methods; D006801:Humans; D009430:Neural Analyzers / Q000187:drug effects* / Q000503:physiopathology; D058958:Organs at Risk; D010597:Pharmacogenetics; D060735:Pharmacovigilance; D012307:Risk Factors; D055493:Spiral Ligament of Cochlea / Q000294:innervation*
chemical_list: D000970:Antineoplastic Agents; D002945:Cisplatin