title: Validation of a paper chromatographic methodology as an alternative for determination of the radiochemical purity of Na18F.
abstract: The aim of the present work was to validate a paper chromatography system as an alternative way to determine the radiochemical purity of Na(18)F.
  
  
  METHODS
  The evaluated parameters were specificity, limit of quantification, measurement interval, linearity, precision, accuracy, and robustness.
  
  
  RESULTS
  The proposed method proved to be linear (P > 0.05; r(2) = 1.000), precise (relative SD, 8.6%), accurate (mean recovery, 95.9%; relative SD, 1.5%-1.8%), and robust under different conditions since no influence of the operative variables on the chromatographic performance was observed.
  
  
  CONCLUSIONS
  This system can be used as a reliable alternative method to determine the radiochemical purity of Na(18)F samples that can be easily performed in PET radiopharmacies at low cost.
authors.affiliation: Laboratorio de Radioisótopos, Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires, Buenos Aires, Argentina. nataliamleonardir@gmail.com
authors.forename: Natalia M
authors.initials: NM
authors.lastname: Leonardi
authors.forename: Guillermo A
authors.initials: GA
authors.lastname: Casale
authors.forename: Jorge
authors.initials: J
authors.lastname: Nicolini
authors.forename: Patricia D
authors.initials: PD
authors.lastname: Zubata
authors.forename: María J
authors.initials: MJ
authors.lastname: Salgueiro
authors.forename: Marcela B
authors.initials: MB
authors.lastname: Zubillaga
mesh_terms: D055598:Chemical Phenomena; D002854:Chromatography, Paper / Q000379:methods*; D005462:Fluorine Radioisotopes; D011786:Quality Control; D011854:Radiochemistry / Q000379:methods*; D012969:Sodium Fluoride / Q000032:analysis* / Q000737:chemistry*
chemical_list: D005462:Fluorine Radioisotopes; D012969:Sodium Fluoride