title: Synthesis of a novel chemotype via sequential metal-catalyzed cycloisomerizations.
abstract: Sequential cycloisomerizations of diynyl o-benzaldehyde substrates to access novel polycyclic cyclopropanes are reported. The reaction sequence involves initial Cu(I)-mediated cycloisomerization/nucleophilic addition to an isochromene followed by diastereoselective Pt(II)-catalyzed enyne cycloisomerization.
authors.affiliation: Department of Chemistry and Center for Chemical Methodology and Library Development (CMLD-BU), Boston University, 590 Commonwealth Avenue, Boston, Massachusetts 02215, USA.
authors.forename: Bo
authors.initials: B
authors.lastname: Leng
authors.forename: Stephanie
authors.initials: S
authors.lastname: Chichetti
authors.forename: Shun
authors.initials: S
authors.lastname: Su
authors.forename: Aaron B
authors.initials: AB
authors.lastname: Beeler
authors.forename: John A
authors.initials: JA
authors.lastname: Porco