title: [Treatment of acute host-versus-graft reaction in patients after allogeneic hematopoietic cell transplantation with multipotent mesenchymal stromal cells from a bone marrow donor].
abstract: OBJECTIVE
  To evaluate the efficiency of administration of multipotent mesenchymal stromal cells obtained from a bone marrow donor for the treatment of an acute host-versus-graft reaction (HVGR) resistant to therapy with glucocorticosteroids (GCS).
  
  
  METHODS
  The experience in treating 6 patients with GCS-resistant acute HVGR following allogeneic hematopoietic stem cell transplantation is given. The patients were intravenously injected cultured multipotent mesenchymal stromal cells (MMSC) in a dose of 10(6) per kg body weight.
  
  
  RESULTS
  Four weeks after MMSC administration, a complete or partial response was obtained in 3 cases; clinical improvement was noted in 2; one patient showed no response. MMSC therapy proved to be effective in 5 of the 6 cases with acute HVGR resistant to GCS therapy.
  
  
  CONCLUSIONS
  MMSC therapy turned out to be effective in case of acute HVGR resistant to GCS therapy.
authors.forename: N A
authors.initials: NA
authors.lastname: Petinati
authors.forename: L A
authors.initials: LA
authors.lastname: Kuz'mina
authors.forename: E N
authors.initials: EN
authors.lastname: Parovichnikova
authors.forename: L S
authors.initials: LS
authors.lastname: Liubimova
authors.forename: E O
authors.initials: EO
authors.lastname: Gribanova
authors.forename: I N
authors.initials: IN
authors.lastname: Shipunova
authors.forename: N I
authors.initials: NI
authors.lastname: Drize
authors.forename: V G
authors.initials: VG
authors.lastname: Savchenko
mesh_terms: D000208:Acute Disease; D000293:Adolescent; D000328:Adult; D016026:Bone Marrow Transplantation / Q000379:methods; D004351:Drug Resistance; D005260:Female; D005938:Glucocorticoids / Q000494:pharmacology; D006086:Graft vs Host Disease / Q000628:therapy*; D018380:Hematopoietic Stem Cell Transplantation / Q000009:adverse effects*; D006801:Humans; D008297:Male; D045164:Mesenchymal Stem Cell Transplantation; D008875:Middle Aged; D014184:Transplantation, Homologous; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D005938:Glucocorticoids