title: Comparative evaluation of decalcified freeze-dried bone allograft use alone and in combination with polylactic acid, polyglycolic acid membrane in the treatment of noncontained human periodontal infrabony defects.
abstract: OBJECTIVE
  To compare the regenerative potential of bone graft used alone and in combination with barrier membrane in noncontained human periodontal infrabony defects.
  
  
  METHODS
  Twelve patients (7 men and 5 women, 30 to 65 years of age) with moderate to severe chronic periodontitis were included in the study. A total of 16 one- or two-walled intraosseous defects were selected and randomly divided for decalcified freeze-dried bone allograft, alone (control group) or in combination with polylactic acid, polyglycolic acid barrier membrane (test group). Pocket probing depth (PPD), clinical attachment level (CAL), radiologic bone fill (RBF), and alveolar height reduction (AHR) were recorded immediately before surgery and after 3 and 6 months postoperatively. The ANOVA and Newman-Keuls post hoc tests were used for statistical analysis. A two-tailed probability value of P < .05 was considered to be statistically significant.
  
  
  RESULTS
  For bone graft alone, PPD reduction was 2.00 ± 0.19 mm, CAL gain was 1.38 ± 0.18 mm, and RBF was 0.63 ± 0.26 mm: for the test group, PPD reduction was 2.75 ± 0.37 mm, CAL gain was 1.50 ± 0.27 mm, and RBF was 1.13 ± 0.23 mm. AHR for the control and test groups was 0.38 and 0.37 mm, respectively.
  
  
  CONCLUSIONS
  These results confirmed nonsignificant clinical and radiologic differences in regenerative outcome with bone graft alone and with guided tissue regeneration in the treatment of noncontained human periodontal infrabony defects.
authors.affiliation: Department of Periodontics, Institute of Dental Sciences, Bareilly, India. drashish.aag@gmail.com
authors.forename: Ashish
authors.initials: A
authors.lastname: Agarwal
authors.forename: Narindra Dev
authors.initials: ND
authors.lastname: Gupta
mesh_terms: D000328:Adult; D000368:Aged; D016301:Alveolar Bone Loss / Q000000981:diagnostic imaging / Q000601:surgery*; D000539:Alveolar Process / Q000000981:diagnostic imaging; D001672:Biocompatible Materials / Q000737:chemistry*; D001861:Bone Regeneration / Q000502:physiology; D016025:Bone Transplantation / Q000379:methods*; D055113:Chronic Periodontitis / Q000601:surgery; D005260:Female; D005500:Follow-Up Studies; D005612:Freeze Drying; D016557:Guided Tissue Regeneration, Periodontal / Q000379:methods; D006801:Humans; D019344:Lactic Acid / Q000737:chemistry*; D008297:Male; D008567:Membranes, Artificial; D008875:Middle Aged; D008963:Molar / Q000000981:diagnostic imaging; D017622:Periodontal Attachment Loss / Q000601:surgery; D010514:Periodontal Pocket / Q000601:surgery; D011100:Polyglycolic Acid / Q000737:chemistry*; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D011859:Radiography; D014021:Tissue Preservation; D014184:Transplantation, Homologous; D016896:Treatment Outcome
chemical_list: D001672:Biocompatible Materials; D008567:Membranes, Artificial; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D011100:Polyglycolic Acid; D019344:Lactic Acid