title: Reflection of ¹⁸F-FDG accumulation in the evaluation of the extent of periapical or periodontal inflammation.
abstract: OBJECTIVE
  To elucidate whether fluorine-18-labeled ((18)F) fluoro-2-deoxy-d-glucose (FDG) accumulation can reflect the extent of periodontal inflammation, periapical inflammation, or dental caries.
  
  
  METHODS
  (18)F-FDG accumulations on positron emission tomography (PET)-computed tomography (CT) were retrospectively compared with the size of the bone resorption areas caused by periodontal inflammation, periapical inflammation, or dental caries on panoramic radiographs, CT, and magnetic resonance imaging (MRI) in 44 subjects.
  
  
  RESULTS
  A significant correlation was found between the size of the bone resorption area caused by periodontal (r = 0.595, P < .01) or periapical (r = 0.560, P < .01) inflammation and the highest standardized uptake value (SUVmax) of (18)F-FDG accumulation. A significant correlation was found between the periodontal (r = 0.622, P < .01) or periapical (r = 0.394, P < .01) inflammatory findings on MRI and the SUVmax of (18)F-FDG accumulation. The SUVmax of (18)F-FDG around most teeth with caries was under 1.5.
  
  
  CONCLUSIONS
  (18)F-FDG accumulation reflects the extent of dental inflammation, not dental caries.
authors.affiliation: Department of Oral Diagnostic Science, Kyushu Dental College, Kitakyushu, Japan.
authors.forename: Shinji
authors.initials: S
authors.lastname: Kito
authors.forename: Hirofumi
authors.initials: H
authors.lastname: Koga
authors.forename: Masaaki
authors.initials: M
authors.lastname: Kodama
authors.forename: Noriaki
authors.initials: N
authors.lastname: Yamamoto
authors.forename: Shinya
authors.initials: S
authors.lastname: Kokuryo
authors.forename: Manabu
authors.initials: M
authors.lastname: Habu
authors.forename: Kou
authors.initials: K
authors.lastname: Matsuo
authors.forename: Takanobu
authors.initials: T
authors.lastname: Nishino
authors.forename: Kohzoh
authors.initials: K
authors.lastname: Kubota
authors.forename: Kosuke
authors.initials: K
authors.lastname: Muraoka
authors.forename: Masafumi
authors.initials: M
authors.lastname: Oda
authors.forename: Nao
authors.initials: N
authors.lastname: Wakasugi-Sato
authors.forename: Shinobu
authors.initials: S
authors.lastname: Matsumoto-Takeda
authors.forename: Yuji
authors.initials: Y
authors.lastname: Seta
authors.forename: Tatsurou
authors.initials: T
authors.lastname: Tanaka
authors.forename: Ikuya
authors.initials: I
authors.lastname: Miyamoto
authors.forename: Yoshihiro
authors.initials: Y
authors.lastname: Yamashita
authors.forename: Chiaki
authors.initials: C
authors.lastname: Kitamura
authors.forename: Keisuke
authors.initials: K
authors.lastname: Nakashima
authors.forename: Tetsu
authors.initials: T
authors.lastname: Takahashi
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Tominaga
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Morimoto
mesh_terms: D019788:Fluorodeoxyglucose F18 / Q000378:metabolism*; D006801:Humans; D007249:Inflammation / Q000378:metabolism*; D010518:Periodontitis / Q000378:metabolism*; D049268:Positron-Emission Tomography
chemical_list: D019788:Fluorodeoxyglucose F18