title: Poly(2-oxazoline)s--are they more advantageous for biomedical applications than other polymers?
abstract: Poly(2-alkyl-2-oxazoline)s are biocompatible polymers with polypeptide-isomeric structures that are attracting increasing interest as biomaterials for drug, gene, protein, and radionuclide delivery. They are, however, still relatively new in comparison to other classes of hydrophilic water-soluble polymers already established for such use, including poly(ethylene oxide), polyvinylpyrrolidone, and polymethacrylamides such as poly[N-(2-hydroxypropyl)methacrylamide]. This feature article critically compares the synthetic aspects and physicochemical and biological properties of poly(2-alkyl-2-oxazoline)s and these commonly studied polymers in terms of their suitability for biomedical applications.
authors.affiliation: Institute of Macromolecular Chemistry, vvi, Academy of Sciences of the Czech Republic, Prague 6, Czech Republic.
authors.forename: Ondrej
authors.initials: O
authors.lastname: Sedlacek
authors.forename: Bryn D
authors.initials: BD
authors.lastname: Monnery
authors.forename: Sergey K
authors.initials: SK
authors.lastname: Filippov
authors.forename: Richard
authors.initials: R
authors.lastname: Hoogenboom
authors.forename: Martin
authors.initials: M
authors.lastname: Hruby
mesh_terms: D001672:Biocompatible Materials / Q000737:chemistry; D004337:Drug Carriers / Q000737:chemistry; D057927:Hydrophobic and Hydrophilic Interactions; D010080:Oxazoles / Q000138:chemical synthesis / Q000737:chemistry*; D011108:Polymers / Q000737:chemistry*; D012996:Solutions / Q000737:chemistry; D014867:Water / Q000737:chemistry
chemical_list: D001672:Biocompatible Materials; D004337:Drug Carriers; D010080:Oxazoles; D011108:Polymers; D012996:Solutions; C577913:poly(2-oxazoline); D014867:Water