title: Transport Risk Index of Physiologic Stability, version II (TRIPS-II): a simple and practical neonatal illness severity score.
abstract: OBJECTIVE
  Derive and validate a practical assessment of infant illness severity at admission to neonatal intensive care units (NICUs).
  
  
  METHODS
  Prospective study involving 17,075 infants admitted to 15 NICUs in 2006 to 2008. Logistic regression was used to derive a prediction model for mortality comprising four empirically weighted items (temperature, blood pressure, respiratory status, response to noxious stimuli). This Transport Risk Index of Physiologic Stability, version II (TRIPS-II) was then validated for prediction of 7-day and total NICU mortality.
  
  
  RESULTS
  TRIPS-II discriminated 7-day (receiver operating curve [ROC] area, 0.90) and total NICU mortality (ROC area, 0.87) from survival. Furthermore, there was a direct association between changes in TRIPS-II at 12 and 24 hours and mortality. There was good calibration across the full range of TRIPS-II scores and the gestational age at birth, and addition of TRIPS-II improved performance of prediction models that use gestational age and baseline population risk variables.
  
  
  CONCLUSIONS
  TRIPS-II is a validated benchmarking tool for assessing infant illness severity at admission and for up to 24 hours after.
authors.affiliation: Department of Pediatrics, University of Toronto, Toronto, Ontario, Canada. sklee@mtsinai.on.ca
authors.forename: Shoo K
authors.initials: SK
authors.lastname: Lee
authors.forename: Khalid
authors.initials: K
authors.lastname: Aziz
authors.forename: Michael
authors.initials: M
authors.lastname: Dunn
authors.forename: Maxine
authors.initials: M
authors.lastname: Clarke
authors.forename: Lajos
authors.initials: L
authors.lastname: Kovacs
authors.forename: Cecil
authors.initials: C
authors.lastname: Ojah
authors.forename: Xiang Y
authors.initials: XY
authors.lastname: Ye
mesh_terms: D001794:Blood Pressure; D001831:Body Temperature; D005260:Female; D017052:Hospital Mortality; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature; D007363:Intensive Care Units, Neonatal; D053609:Lethargy; D008297:Male; D015999:Multivariate Analysis; D010092:Oximetry; D011379:Prognosis; D011446:Prospective Studies; D012372:ROC Curve; D015203:Reproducibility of Results; D012127:Respiratory Distress Syndrome, Newborn / Q000175:diagnosis*; D012720:Severity of Illness Index