title: [Metabolic interactions between the hyperhomocysteinemia and angiotensin-1 converting enzyme activity in Tunisian patients with coronary heart disease].
abstract: Hyperhomocysteinemia and hyperactivity of the angiotensin-1 converting enzyme (ACE1) are considered two unconventional coronary risk factors. The study of the variation of these two biochemical parameters in coronary patients and metabolic investigation of the relationship between these two markers has a fundamental interest. In this context, 110 patients and 80 control subjects are recruited for our study. Homocystenemia was determined by fluorescence polarization immunoassay (FPIA). ACE1 activity was measured by kinetic method. An increased of homocysteinemia and ACE1 activity was observed in patients compared with control subjects (Hcy: 23±18 μmol/L vs 9±4 μmol /L; p<0.0001); (ACEI: 81±18 UI/L vs 55±18 UI/L; p<0.0001). These two markers varied differently according to the risk factors. Homocysteinemia, was negatively correlated with ACE1 activity (r = -0.36; p<0.001). The negative correlation between these two markers reflects metabolic and physiopathological interactions.
authors.affiliation: Laboratoire de biochimie, CHU Farhat Hached, Sousse, Tunisie.
authors.forename: Abdelkader
authors.initials: A
authors.lastname: Chalghoum
authors.forename: Yosri
authors.initials: Y
authors.lastname: Noichri
authors.forename: Latifa
authors.initials: L
authors.lastname: Chkioua
authors.forename: Imene
authors.initials: I
authors.lastname: Gammoudi
authors.forename: Azza
authors.initials: A
authors.lastname: Dandana
authors.forename: Souhir
authors.initials: S
authors.lastname: Khelil
authors.forename: Guider
authors.initials: G
authors.lastname: Jeridi
authors.forename: Bruno
authors.initials: B
authors.lastname: Baudin
authors.forename: Salima
authors.initials: S
authors.lastname: Ferchichi
authors.forename: Abdelhedi
authors.initials: A
authors.lastname: Miled
mesh_terms: D000328:Adult; D000368:Aged; D016022:Case-Control Studies; D003327:Coronary Disease / Q000097:blood / Q000453:epidemiology* / Q000209:etiology / Q000378:metabolism*; D005260:Female; D006710:Homocysteine / Q000032:analysis / Q000097:blood; D006801:Humans; D020138:Hyperhomocysteinemia / Q000097:blood / Q000150:complications / Q000453:epidemiology* / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D007703:Peptidyl-Dipeptidase A / Q000097:blood / Q000378:metabolism*; D012307:Risk Factors; D014416:Tunisia / Q000453:epidemiology
chemical_list: D006710:Homocysteine; D007703:Peptidyl-Dipeptidase A