title: New evidence in theory of mind deficits in subjects with chronic schizophrenia and first episode: correlation with symptoms, neurocognition and social function.
abstract: OBJECTIVE
  Currently substantial evidence exists about Theory of Mind (ToM) impairment in subjects affected by chronic and first episode schizophrenia. In particular, in order to enhance the validity of our construct, we used in this study classical false beliefs tasks and advanced theory of mind tasks, together with the application of structural equation model, in order to ex-amine whether we are using ToM tasks with good psychometric properties. The main goal of the present study was to examine ToM deficits in a large sample including subjects suffering from chronic schizophrenia, first episode of schizophrenia and nor-mal controls, by observing in the same task the relationship with symptomatological gravity, neurocognition and social function.Materials and methods. A sample of 178 patients with chronic schizophrenia, a sample of 49 subjects with a first episode of psychosis and 484 healthy controls participated to this study. Measures of social cognition included task of false belief and advanced theory of mind task.
  
  
  RESULTS
  No significant differences were found on ToM tasks between subjects affected by chronic and first episode schizophrenia. Social cognition showed in both groups a strong correlation with negative symptoms and social function, but did not evidence any relationship with neurocognition. CONCLUSION; ToM deficits exist in subjects suffering from chronic and first episode schizophrenia. These impairments do not seem to be a consequence of illness condition, they are likely to be state-independent and appear to be the most important cognitive mediator of social functioning in both groups.
authors.affiliation: Department of Science of Health, University of L'Aquila, Italy. monica.mazza@cc.univaq.it
authors.forename: Monica
authors.initials: M
authors.lastname: Mazza
authors.forename: Rocco
authors.initials: R
authors.lastname: Pollice
authors.forename: Francesca
authors.initials: F
authors.lastname: Pacitti
authors.forename: Maria Chiara
authors.initials: MC
authors.lastname: Pino
authors.forename: Melania
authors.initials: M
authors.lastname: Mariano
authors.forename: Simona
authors.initials: S
authors.lastname: Tripaldi
authors.forename: Massimo
authors.initials: M
authors.lastname: Casacchia
authors.forename: Rita
authors.initials: R
authors.lastname: Roncone
mesh_terms: D000328:Adult; D003071:Cognition; D005260:Female; D006801:Humans; D008297:Male; D012559:Schizophrenia / Q000175:diagnosis*; D012565:Schizophrenic Psychology; D012917:Social Adjustment; D056345:Theory of Mind