title: [Adverse events following vaccination against pandemic influenza A (H1N1) 2009 in children].
abstract: The aim of this study was to estimate the frequency of adverse events following vaccination against pandemic influenza A (H1N1) 2009 and associated factors in children from six months to two years of age (n = 156). Multivariate Cox regression was used to assess the independent associations between covariates and complaints of at least one adverse event. Strength of association was measured by hazard ratios and respective 95% confidence intervals. Following the first dose, 40.3% of parents reported one or more adverse events in their children, compared to 35.5% after the second dose. Systemic adverse events, specifically irritation, diarrhea, and fever, were more frequent than local reactions at the vaccination site. Incidence rates for adverse events in general and systemic reactions following the first dose were higher in children with concomitant illness or allergies (HR = 3.43, 95%CI: 1.34-8.77 and HR = 2.76, 95%CI: 1.11-6.89). Most events were mild. Cases of high fever, vomiting, and diarrhea prompted parents to seek care for their children at health services.
authors.affiliation: Escola de Enfermagem, Universidade Federal de Minas Gerais, Belo Horizonte, Brasil.
authors.forename: Gisele Nepomuceno de
authors.initials: GN
authors.lastname: Andrade
authors.forename: Adriano Marçal
authors.initials: AM
authors.lastname: Pimenta
authors.forename: Débora Arreguy
authors.initials: DA
authors.lastname: Silva
authors.forename: Anézia Moreira Faria
authors.initials: AM
authors.lastname: Madeira
mesh_terms: D016907:Adverse Drug Reaction Reporting Systems / Q000706:statistics & numerical data; D017677:Age Distribution; D001938:Brazil / Q000453:epidemiology; D002675:Child, Preschool; D003967:Diarrhea / Q000209:etiology; D004812:Epidemiologic Methods; D005260:Female; D005334:Fever / Q000139:chemically induced; D006801:Humans; D007223:Infant; D053118:Influenza A Virus, H1N1 Subtype / Q000276:immunology*; D007252:Influenza Vaccines / Q000008:administration & dosage / Q000009:adverse effects*; D007251:Influenza, Human / Q000453:epidemiology / Q000276:immunology / Q000517:prevention & control*; D007508:Irritable Mood; D008297:Male; D058873:Pandemics; D017678:Sex Distribution; D020458:Third-Party Consent
chemical_list: D007252:Influenza Vaccines