title: A new paradigm in viral resistance.
abstract: The rapid mutation of RNA viruses allows for the acquisition of resistance to drugs directly targeting viral proteins. Therefore, a novel approach to the development of antivirals centers on targeting host factors critical to viral replication. A recent report has brought to light the potential for RNA viruses to also develop resistance against compounds targeting crucial host factors, suggesting that a combination of drugs with various targets may be necessary for preventing resistance.
authors.affiliation: Department of Molecular Medicine, Mayo Clinic, Rochester, Minnesota 55905, USA.
authors.forename: Autumn
authors.initials: A
authors.lastname: Ruiz
authors.forename: Stephen J
authors.initials: SJ
authors.lastname: Russell
mesh_terms: D000998:Antiviral Agents / Q000494:pharmacology* / Q000627:therapeutic use; D004338:Drug Combinations; D024882:Drug Resistance, Viral / Q000235:genetics*; D004770:Enterovirus / Q000187:drug effects* / Q000235:genetics; D004769:Enterovirus Infections / Q000188:drug therapy* / Q000821:virology; D014644:Genetic Variation; D006801:Humans; D009154:Mutation; D014764:Viral Proteins / Q000187:drug effects*; D014779:Virus Replication / Q000187:drug effects* / Q000235:genetics
chemical_list: D000998:Antiviral Agents; D004338:Drug Combinations; D014764:Viral Proteins