title: Hodgkin lymphoma.
abstract: Hodgkin lymphoma (HL), a B cell-derived cancer, is one of the most common lymphomas. In HL, the tumor cells--Hodgkin and Reed-Sternberg (HRS) cells--are usually very rare in the tissue. Although HRS cells are derived from mature B cells, they have largely lost their B cell phenotype and show a very unusual co-expression of markers of various hematopoietic cell types. HRS cells show deregulated activation of multiple signaling pathways and transcription factors. The activation of these pathways and factors is partly mediated through interactions of HRS cells with various other types of cells in the microenvironment, but also through genetic lesions. The transforming events involved in the pathogenesis of HL are only partly understood, but mutations affecting the NF-κB and JAK/STAT pathways are frequent. The dependency of HRS cells on microenvironmental interactions and deregulated signaling pathways may offer novel strategies for targeted therapies.
authors.affiliation: Institute of Cell Biology (Cancer Research), Medical School, University of Duisburg-Essen, Essen, Germany. ralf.kueppers@uk-essen.de
authors.forename: Ralf
authors.initials: R
authors.lastname: Küppers
authors.forename: Andreas
authors.initials: A
authors.lastname: Engert
authors.forename: Martin-Leo
authors.initials: ML
authors.lastname: Hansmann
mesh_terms: D000944:Antigens, Differentiation, B-Lymphocyte / Q000032:analysis; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D001402:B-Lymphocytes / Q000473:pathology; D019070:Cell Lineage; D002471:Cell Transformation, Neoplastic / Q000235:genetics; D059248:Chemoradiotherapy; D002986:Clinical Trials as Topic; D020031:Epstein-Barr Virus Infections / Q000473:pathology; D015972:Gene Expression Regulation, Neoplastic; D018095:Germ-Line Mutation; D004854:Herpesvirus 4, Human / Q000235:genetics / Q000472:pathogenicity; D006689:Hodgkin Disease / Q000145:classification / Q000209:etiology / Q000235:genetics / Q000473:pathology / Q000628:therapy / Q000821:virology; D006801:Humans; D058990:Molecular Targeted Therapy; D016328:NF-kappa B / Q000378:metabolism; D009363:Neoplasm Proteins / Q000096:biosynthesis / Q000235:genetics / Q000502:physiology; D010641:Phenotype; D016539:Reed-Sternberg Cells / Q000276:immunology / Q000473:pathology; D015398:Signal Transduction / Q000235:genetics / Q000502:physiology; D014157:Transcription Factors / Q000235:genetics / Q000502:physiology; D059016:Tumor Microenvironment; D014412:Tumor Virus Infections / Q000473:pathology
chemical_list: D000944:Antigens, Differentiation, B-Lymphocyte; D016328:NF-kappa B; D009363:Neoplasm Proteins; D014157:Transcription Factors