title: The safety of flucloxacillin in HIV-infected patients with positive HLA-B*5701 genotype.
abstract: Positive HLA-B*5701 genotype has recently been identified as the main genetic risk factor for flucloxacillin drug-induced liver injury (DILI). Testing for HLA-B*5701 is routine in many HIV clinics to identify those at risk of hypersensitivity reaction (HSR) to abacavir. Considering the high prevalence of soft-tissue infections in HIV patients, we conducted a retrospective study to investigate whether flucloxacillin use was associated with adverse events in HIV patients known to be HLA-B*5701 positive.
authors.affiliation: Department of Medicine, Section of infectious Diseases, Imperial College London, UK. j.vera@imperial.ac.uk
authors.forename: Jaime H
authors.initials: JH
authors.lastname: Vera
authors.forename: Nadia
authors.initials: N
authors.lastname: Naous
authors.forename: Nicola
authors.initials: N
authors.lastname: Mackie
authors.forename: Alan
authors.initials: A
authors.lastname: Winston
authors.forename: Graham
authors.initials: G
authors.lastname: Cooke
mesh_terms: D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000009:adverse effects*; D019380:Anti-HIV Agents / Q000627:therapeutic use; D056486:Chemical and Drug Induced Liver Injury / Q000209:etiology* / Q000235:genetics / Q000276:immunology; D004342:Drug Hypersensitivity / Q000235:genetics / Q000276:immunology; D005260:Female; D005436:Floxacillin / Q000008:administration & dosage / Q000009:adverse effects*; D005838:Genotype; D015658:HIV Infections / Q000188:drug therapy / Q000235:genetics / Q000276:immunology*; D015235:HLA-B Antigens / Q000187:drug effects* / Q000235:genetics; D006801:Humans; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D012307:Risk Factors
chemical_list: D000900:Anti-Bacterial Agents; D019380:Anti-HIV Agents; D015235:HLA-B Antigens; C484830:HLA-B*57:01 antigen; D005436:Floxacillin