title: Involvement of the sigma1 receptor in the antidepressant-like effects of fluvoxamine in the forced swimming test in comparison with the effects elicited by paroxetine.
abstract: We studied the involvement of the sigma(1) receptor in the antidepressant-like effects of the selective serotonin reuptake inhibitor (SSRI) fluvoxamine in DBA/2 mice using the forced swimming test. The effects of the selective sigma(1) receptor antagonist N-[2-(3,4-dichlorophenyl)ethyl]-N-methyl-2-(dimethylamino) ethylamine (BD1047) at 1mg/kg significantly antagonized the anti-immobility elicited by fluvoxamine (10mg/kg). However, the anti-immobility effects elicited by another SSRI, paroxetine (5m/kg), were not altered by BD1047. The selective sigma(1) receptor agonist 2S-(2α,6α,11R(*))-1,2,3,4,5,6-hexahydro-6,11-dimethyl-3-(2-propenyl)-2,6-methano-3-benzazocin-8-ol ((+)SKF-10047) elicited dose-dependent anti-immobility effects in DBA/2 mice. BD1047 significantly blocked the anti-immobility effects induced by (+)SKF-10047 at 10mg/kg. These results suggested that the sigma(1) receptor was associated with fluvoxamine-induced antidepressant-like effects but not with paroxetine-induced antidepressant-like effects.
authors.affiliation: Laboratory of Pharmacology, Department of Clinical Pharmacy, Yokohama College of Pharmacy, 601 Matano-cho, Totsuka-ku, Yokohama 245-0066, Japan. yumisugi@hamayaku.ac.jp
authors.forename: Yumi
authors.initials: Y
authors.lastname: Sugimoto
authors.forename: Noriko
authors.initials: N
authors.lastname: Tagawa
authors.forename: Yoshiharu
authors.initials: Y
authors.lastname: Kobayashi
authors.forename: Kumiko
authors.initials: K
authors.lastname: Mitsui-Saito
authors.forename: Yoshihiro
authors.initials: Y
authors.lastname: Hotta
authors.forename: Jun
authors.initials: J
authors.lastname: Yamada
mesh_terms: D000818:Animals; D018687:Antidepressive Agents, Second-Generation / Q000494:pharmacology*; D001522:Behavior, Animal / Q000187:drug effects; D016666:Fluvoxamine / Q000494:pharmacology*; D008297:Male; D051379:Mice; D008811:Mice, Inbred DBA; D009043:Motor Activity / Q000187:drug effects; D017374:Paroxetine / Q000494:pharmacology*; D017480:Receptors, sigma / Q000502:physiology*; D013550:Swimming; D000097605:Sigma-1 Receptor
chemical_list: D018687:Antidepressive Agents, Second-Generation; D016666:Fluvoxamine; D017374:Paroxetine; D017480:Receptors, sigma; D000097605:Sigma-1 Receptor