title: Redox and nitrosative regulation of cardiac remodeling.
abstract: Heart disease is a major cause of death and morbidity worldwide, particularly so in industrialized nations. A major contributor to its varied pathophysiology is abnormal oxidative/reductive and nitrosative stress. While oxidant-scavenging therapies for cardiovascular disease have been disappointing to date, new insights into the precise sources of oxidative/nitrosative stress, its compartmentalized targets, and the modulators designed to control it are paving the way for a very different approach. This issue of the journal presents a Forum highlighting recent work from an international network of investigators that focuses on the role of oxidative/nitrosative stress in the remodeling heart.
authors.forename: David A
authors.initials: DA
authors.lastname: Kass
authors.forename: Ajay M
authors.initials: AM
authors.lastname: Shah
mesh_terms: D006333:Heart Failure / Q000188:drug therapy / Q000503:physiopathology; D006801:Humans; D008955:Models, Cardiovascular; D058990:Molecular Targeted Therapy; D015538:Nitrosation; D010084:Oxidation-Reduction; D018384:Oxidative Stress; D015398:Signal Transduction; D020257:Ventricular Remodeling / Q000502:physiology*