title: [A case of protein-losing gastroenteropathy accompanied by Sjögren syndrome and mixed connective tissue disease].
abstract: Case reports of protein-losing gastroenteropathy (PLGE) associated with not only mixed connective tissue disease (MCTD) but also Sjögren syndrome (SjS) are very rare. We report a first case of PLGE in a patient with both MCTD and SjS. A 58-year-old Japanese woman was referred and admitted to our hospital because of abdominal fullness and lower leg edema. Her past medical history revealed SjS at age 40. Physical examination demonstrated lower leg edema and Raynaud's phenomenon. Blood chemistry data showed severe hypoproteinemia. Anti RNP antibody was positive. MCTD was diagnosed. The alpha-1 antitrypsin clearance level was high. The (99m)Tc-DTPA human serum albumin scintigraphy demonstrated abnormal accumulation in the intestine. PLGE associated with both MCTD and SjS was diagnosed, but she was successfully treated by prednisolone.
authors.affiliation: Clinical Research Center, National Hospital Organization Kyushu Medical Center, Japan.
authors.forename: Kana
authors.initials: K
authors.lastname: Kakigao
authors.forename: Nobuyoshi
authors.initials: N
authors.lastname: Fukushima
authors.forename: Takahiro
authors.initials: T
authors.lastname: Mizutani
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Haraguchi
authors.forename: Risa
authors.initials: R
authors.lastname: Okamoto
authors.forename: Noriko
authors.initials: N
authors.lastname: Sawamura
authors.forename: Tomoko
authors.initials: T
authors.lastname: Oohashi
authors.forename: Aya
authors.initials: A
authors.lastname: Mitsuyasu
authors.forename: Takashi
authors.initials: T
authors.lastname: Fujiyama
authors.forename: Tsuyoshi
authors.initials: T
authors.lastname: Yoshimoto
authors.forename: Motoyuki
authors.initials: M
authors.lastname: Koujima
authors.forename: Ken
authors.initials: K
authors.lastname: Kawabe
authors.forename: Kunitaka
authors.initials: K
authors.lastname: Fukuizumi
authors.forename: Makoto
authors.initials: M
authors.lastname: Nakamuta
authors.forename: Naohiko
authors.initials: N
authors.lastname: Harada
mesh_terms: D005260:Female; D006801:Humans; D008875:Middle Aged; D008947:Mixed Connective Tissue Disease / Q000150:complications*; D011504:Protein-Losing Enteropathies / Q000150:complications*; D012859:Sjogren's Syndrome / Q000150:complications*