title: Interleukin-10 promoter polymorphisms and asthma risk: a meta-analysis.
abstract: Several studies assessed the associations of interleukin-10 (IL-10) polymorphisms with asthma in different populations. However, the results were inconclusive. The aim of the present study was to further assess the associations by the method of meta-analysis. Pubmed, EMBASE, Wanfang Database, China National Knowledge Infrastructure (CNKI) and Weipu Database were searched. Data were extracted independently by two authors. Odds ratios (ORs) with 95% confidence intervals (CIs) were used to assess the strength of associations. Seventeen potentially eligible articles were identified (4478 cases and 4803 controls). Significant associations between -1082A/G and -592A/C polymorphisms and asthma were observed. However, there was no significant association between -819T/C polymorphism and asthma risk. In addition, there were significant associations of the IL-10 haplotypes with asthma. In summary, this meta-analysis suggested that IL-10 promoter polymorphisms were associated with asthma risk.
authors.affiliation: Department of Respiratory Disease, Shanghai Changzheng Hospital, Second Military Medical University, Shanghai 200003, China. niewei-1001@163.com
authors.forename: Wei
authors.initials: W
authors.lastname: Nie
authors.forename: Zheng
authors.initials: Z
authors.lastname: Fang
authors.forename: Bing
authors.initials: B
authors.lastname: Li
authors.forename: Qing-yu
authors.initials: QY
authors.lastname: Xiu
mesh_terms: D001249:Asthma / Q000235:genetics*; D020022:Genetic Predisposition to Disease; D006239:Haplotypes / Q000235:genetics; D006801:Humans; D016753:Interleukin-10 / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D011401:Promoter Regions, Genetic; D012307:Risk Factors
chemical_list: D016753:Interleukin-10