title: Enzyme-responsive polymeric supra-amphiphiles formed by the complexation of chitosan and ATP.
abstract: Chitosan and adenosine-5'-triphosphate (ATP) are employed as building blocks to fabricate polymeric supra-amphiphiles based on electrostatic interactions, which can self-assemble to form spherical aggregates. The spherical aggregates inherit the phosphotase responsiveness of ATP. Compared to our previous work, this enzyme-responsive system can be more biocompatible and block polymers are not needed in preparation, which makes it possible to fabricate the chitosan-based enzyme-responsive assemblies in a large-scale, cheap way. Therefore, the application of the assemblies for nanocontainers and drug delivery is greatly anticipated.
authors.affiliation: Key Lab of Organic Optoelectronics & Molecular Engineering, Department of Chemistry, Tsinghua University, Beijing 100084, People's Republic of China.
authors.forename: Yuetong
authors.initials: Y
authors.lastname: Kang
authors.forename: Chao
authors.initials: C
authors.lastname: Wang
authors.forename: Kai
authors.initials: K
authors.lastname: Liu
authors.forename: Zhiqiang
authors.initials: Z
authors.lastname: Wang
authors.forename: Xi
authors.initials: X
authors.lastname: Zhang
mesh_terms: D000255:Adenosine Triphosphate / Q000737:chemistry / Q000378:metabolism*; D000469:Alkaline Phosphatase / Q000737:chemistry / Q000378:metabolism*; D000818:Animals; D002417:Cattle; D048271:Chitosan / Q000737:chemistry / Q000378:metabolism*; D057927:Hydrophobic and Hydrophilic Interactions; D007422:Intestines / Q000201:enzymology*; D010316:Particle Size; D011108:Polymers / Q000737:chemistry / Q000378:metabolism*; D013499:Surface Properties; D013501:Surface-Active Agents / Q000737:chemistry / Q000378:metabolism*
chemical_list: D011108:Polymers; D013501:Surface-Active Agents; D000255:Adenosine Triphosphate; D048271:Chitosan; D000469:Alkaline Phosphatase