title: Guadial A and psiguadials C and D, three unusual meroterpenoids from Psidium guajava.
abstract: The first monoterpene-based meroterpenoid (1) and two novel sesquiterpene-based ones (2 and 3) with unprecedented skeletons were isolated from the leaves of Psidium guajava. Their structures with absolute configuration were elucidated by extensive spectroscopic studies. A plausible biosynthetic pathway for all meroterpenoids from the title plant is also proposed. Compounds 2 and 3 showed significant cytotoxicity toward HepG2 and HepG2/ADM cells.
authors.affiliation: Institute of Traditional Chinese Medicine & Natural Products, Jinan University, Guangzhou 510632, PR China.
authors.forename: Meng
authors.initials: M
authors.lastname: Shao
authors.forename: Ying
authors.initials: Y
authors.lastname: Wang
authors.forename: Yu-Qing
authors.initials: YQ
authors.lastname: Jian
authors.forename: Xiao-Jun
authors.initials: XJ
authors.lastname: Huang
authors.forename: Dong-Mei
authors.initials: DM
authors.lastname: Zhang
authors.forename: Qing-Fa
authors.initials: QF
authors.lastname: Tang
authors.forename: Ren-Wang
authors.initials: RW
authors.lastname: Jiang
authors.forename: Xue-Gang
authors.initials: XG
authors.lastname: Sun
authors.forename: Zhi-Ping
authors.initials: ZP
authors.lastname: Lv
authors.forename: Xiao-Qi
authors.initials: XQ
authors.lastname: Zhang
authors.forename: Wen-Cai
authors.initials: WC
authors.lastname: Ye
mesh_terms: D001578:Benzopyrans / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D002470:Cell Survival / Q000187:drug effects; D056945:Hep G2 Cells; D006801:Humans; D008958:Models, Molecular; D015394:Molecular Structure; D031647:Psidium / Q000737:chemistry*; D012717:Sesquiterpenes / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology
chemical_list: D001578:Benzopyrans; D012717:Sesquiterpenes; C582902:psiguadial C; C582903:psiguadial D