title: Complete genome sequence of Le Blanc virus, a third Caenorhabditis nematode-infecting virus.
abstract: Orsay virus and Santeuil virus, the first known viruses capable of naturally infecting the nematodes Caenorhabditis elegans and Caenorhabditis briggsae, respectively, were recently identified by high-throughput sequencing of wild Caenorhabditis strains. By similar analysis of another wild C. briggsae isolate, we have now discovered and sequenced the complete genome of a third novel virus, Le Blanc virus, that is distantly related to Orsay and Santeuil viruses. All three viruses are positive-sense RNA viruses with bipartite genomes that are most closely related to nodaviruses. Identification of a third virus capable of infecting Caenorhabditis nematodes enables comparative analysis of this clade of viruses and strengthens this model for investigating virus-host interactions.
authors.affiliation: Departments of Molecular Microbiology and Pathology & Immunology, Washington University in St. Louis School of Medicine, St. Louis, Missouri, USA.
authors.forename: Carl J
authors.initials: CJ
authors.lastname: Franz
authors.forename: Guoyan
authors.initials: G
authors.lastname: Zhao
authors.forename: Marie-Anne
authors.initials: MA
authors.lastname: Félix
authors.forename: David
authors.initials: D
authors.lastname: Wang
mesh_terms: D000818:Animals; D002107:Caenorhabditis / Q000821:virology; D016000:Cluster Analysis; D016679:Genome, Viral; D008969:Molecular Sequence Data; D010802:Phylogeny; D012328:RNA Viruses / Q000145:classification / Q000235:genetics* / Q000302:isolation & purification; D012367:RNA, Viral / Q000235:genetics*; D017422:Sequence Analysis, DNA
chemical_list: D012367:RNA, Viral