title: Pharmacogenetic determinant of the drug interaction between tacrolimus and omeprazole.
abstract: A 17-year-old adolescent with acute nephrotoxicity had CYP3A4-5, CYP2C19, and ABCB1 genotyping performed to understand a suspected drug interaction between tacrolimus and omeprazole. The determinant role of individual pharmacogenetic profile in the occurrence of tacrolimus nephrotoxicity is presented and discussed.
authors.affiliation: AP-HP, Department of Pediatric Pharmacology and Pharmacogenetics, Hôpital Robert Debré, INSERM, Paris, France.
authors.forename: Wei
authors.initials: W
authors.lastname: Zhao
authors.forename: May
authors.initials: M
authors.lastname: Fakhoury
authors.forename: Anne
authors.initials: A
authors.lastname: Maisin
authors.forename: Véronique
authors.initials: V
authors.lastname: Baudouin
authors.forename: Thomas
authors.initials: T
authors.lastname: Storme
authors.forename: Georges
authors.initials: G
authors.lastname: Deschênes
authors.forename: Evelyne
authors.initials: E
authors.lastname: Jacqz-Aigrain
mesh_terms: D018435:ATP Binding Cassette Transporter, Subfamily B; D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1 / Q000235:genetics / Q000378:metabolism; D000293:Adolescent; D000897:Anti-Ulcer Agents / Q000009:adverse effects*; D001189:Aryl Hydrocarbon Hydroxylases / Q000235:genetics / Q000378:metabolism; D001711:Biotransformation / Q000187:drug effects; D065731:Cytochrome P-450 CYP2C19; D051544:Cytochrome P-450 CYP3A / Q000235:genetics / Q000378:metabolism; D004347:Drug Interactions; D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects / Q000097:blood / Q000493:pharmacokinetics*; D016030:Kidney Transplantation / Q000009:adverse effects; D009853:Omeprazole / Q000009:adverse effects*; D016559:Tacrolimus / Q000009:adverse effects / Q000097:blood / Q000493:pharmacokinetics*; D016896:Treatment Outcome
chemical_list: C513055:ABCB1 protein, human; D018435:ATP Binding Cassette Transporter, Subfamily B; D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1; D000897:Anti-Ulcer Agents; D007166:Immunosuppressive Agents; D001189:Aryl Hydrocarbon Hydroxylases; C045793:CYP2C19 protein, human; C510164:CYP3A5 protein, human; D065731:Cytochrome P-450 CYP2C19; D051544:Cytochrome P-450 CYP3A; C510163:CYP3A4 protein, human; D009853:Omeprazole; D016559:Tacrolimus