title: Use of species sensitivity distributions to predict no-effect concentrations of an antifouling biocide, pyridine triphenylborane, for marine organisms.
abstract: We used species sensitivity distributions (SSDs) and a Bayesian statistical model to carry out a primary risk assessment for pyridine triphenylborane (PTPB) in Hiroshima Bay, Japan. We used SSDs derived from toxicity values, such as EC₅₀ and LC₅₀, obtained from this study and previous work to calculate hazardous concentrations that should protect 95% and 99% of species (HC₅ and HC₁) and demonstrated that the medians of the HC₅ and HC₁ were 0.78 and 0.17 μg/L, respectively. We also used liquid chromatography/mass spectrometry to investigate the occurrence of PTPB in seawater from several coastal sites of Hiroshima Bay and detected PTPB at concentrations of 4.8-21 pg/L. Comparison of environmental concentrations to the HC values suggests that the current ecological risk posed by PTPB in Hiroshima Bay is low. This is the first report of the detection of PTPB in the natural marine environment.
authors.affiliation: National Research Institute of Fisheries and Environment of Inland Sea, Fisheries Research Agency, 2-17-5 Maruishi, Hatsukaichi, Hiroshima 739-0452, Japan. kmochida@fra.affrc.go.jp
authors.forename: Kazuhiko
authors.initials: K
authors.lastname: Mochida
authors.forename: Toshimitsu
authors.initials: T
authors.lastname: Onduka
authors.forename: Haruna
authors.initials: H
authors.lastname: Amano
authors.forename: Mana
authors.initials: M
authors.lastname: Ito
authors.forename: Katsutoshi
authors.initials: K
authors.lastname: Ito
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Tanaka
authors.forename: Kazunori
authors.initials: K
authors.lastname: Fujii
mesh_terms: D000818:Animals; D059001:Aquatic Organisms / Q000187:drug effects*; D001880:Boranes / Q000032:analysis / Q000633:toxicity*; D004202:Disinfectants / Q000032:analysis / Q000633:toxicity*; D004305:Dose-Response Relationship, Drug; D004784:Environmental Monitoring; D007928:Lethal Dose 50; D019055:No-Observed-Adverse-Effect Level; D011725:Pyridines / Q000032:analysis / Q000633:toxicity*; D018570:Risk Assessment; D012623:Seawater / Q000737:chemistry*; D012680:Sensitivity and Specificity; D014874:Water Pollutants, Chemical / Q000032:analysis / Q000633:toxicity*
chemical_list: D001880:Boranes; D004202:Disinfectants; D011725:Pyridines; D014874:Water Pollutants, Chemical; C577849:pyridine triphenylborane