title: Endogenous anticoagulants.
abstract: Blood coagulation is a complex and highly coordinated process that is constantly altered and impacted by procoagulant and anticoagulant "players." It is vital that these components work in concert to maintain a balance to keep coagulation in check. Several important endogenous anticoagulants will be discussed in this review including tissue factor pathway inhibitor, antithrombin, protein C, and protein S in origin, structure, mechanism of action, effects of deficiency, and current knowledge in veterinary medicine.
authors.affiliation: University of Illinois Urbana-Champaign, Champaign, IL, USA. kubier@illinois.edu
authors.forename: Amy
authors.initials: A
authors.lastname: Kubier
authors.forename: Mauria
authors.initials: M
authors.lastname: O'Brien
mesh_terms: D000818:Animals; D000925:Anticoagulants / Q000502:physiology*; D000991:Antithrombins / Q000502:physiology / Q000627:therapeutic use; D001777:Blood Coagulation / Q000502:physiology*; D001778:Blood Coagulation Disorders / Q000097:blood / Q000188:drug therapy / Q000503:physiopathology / Q000662:veterinary*; D002371:Cat Diseases / Q000097:blood / Q000188:drug therapy / Q000503:physiopathology; D002415:Cats; D004283:Dog Diseases / Q000097:blood / Q000188:drug therapy / Q000503:physiopathology; D004285:Dogs; D006706:Homeostasis / Q000502:physiology*; D008074:Lipoproteins / Q000502:physiology / Q000627:therapeutic use; D011486:Protein C / Q000502:physiology / Q000627:therapeutic use; D017293:Protein S / Q000502:physiology / Q000627:therapeutic use
chemical_list: D000925:Anticoagulants; D000991:Antithrombins; D008074:Lipoproteins; D011486:Protein C; D017293:Protein S; C051928:lipoprotein-associated coagulation inhibitor