title: Genomic dysregulation in gastric tumors.
abstract: Gastric cancer is among the most common human malignancies and the second leading cause of cancer-related death. The different epidemiologic and histopathology of subtypes of gastric cancer are associated with different genomic patterns. Data suggests that gene expression patterns of proximal, distal gastric cancers-intestinal type, and diffuse/signet cell are well separated. This review summarizes the genetic and epigenetic changes thought to drive gastric cancer and the emerging paradigm of gastric cancer as three unique disease subtypes.
authors.affiliation: Department of Medicine, Gastrointestinal Oncology Service, Memorial Sloan-Kettering Cancer Center, Weill Cornell Medical College of Cornell University, New York, New York 10065, USA. janjigiy@mskcc.org
authors.forename: Yelena Y
authors.initials: YY
authors.lastname: Janjigian
authors.forename: David P
authors.initials: DP
authors.lastname: Kelsen
mesh_terms: D002869:Chromosome Aberrations; D044127:Epigenesis, Genetic; D006801:Humans; D013274:Stomach Neoplasms / Q000145:classification / Q000209:etiology*