title: Associations between bilateral subthalamic nucleus deep brain stimulation (STN-DBS) and anxiety in Parkinson's disease patients: a controlled study.
abstract: The authors explored the associations between subthalamic nucleus deep brain stimulation (STN-DBS) and anxiety in Parkinson's disease (PD) patients. Recent research suggests that anxiety may be one of the earliest manifestations of PD; however, the lack of a dopamine-medication control group is a major limitation of these studies. Authors paired a group of 31 bilateral STN-DBS PD patients (STN-DBS group) with 31 dopamine-medicated PD patients (Medication-control group) and used various psychological assessment scales for group evaluations. These were completed 1 month preoperatively, and 3 weeks, 5 weeks, 2 months, 4 months, 7 months, and 13 months postoperatively. As compared with the Medication group, the STN-DBS group improved in motor functioning and general status after 1 week Stimulator Power-On; State-Anxiety improved significantly at 1 week and 1 month after Stimulator Power-On, but was not significant at the subsequent time-points. Anxiety scores remained stable before 3rd-month Stimulator Power-On, but got worse after that time. In the STN-DBS group, S-AI was positively related to motor symptoms and life quality preoperatively and 4 months postoperatively, but, in the Medication group, this correlation existed throughout the study. PD-related anxiety decreased in STN-DBS patients because of the improvement in motor function for a short time; however, as the voltages and pulse-widths grew higher with time, the PD-related anxiety became worse.
authors.affiliation: Department of Neurosurgery, Tangdu Hospital, Fourth Military Medical University, 1 Xinsi Road, Xi’an, Shaanxi Province 710038, China.
authors.forename: Chongwang
authors.initials: C
authors.lastname: Chang
authors.forename: Nan
authors.initials: N
authors.lastname: Li
authors.forename: Yuyan
authors.initials: Y
authors.lastname: Wu
authors.forename: Ning
authors.initials: N
authors.lastname: Geng
authors.forename: Shunnan
authors.initials: S
authors.lastname: Ge
authors.forename: Jing
authors.initials: J
authors.lastname: Wang
authors.forename: Xin
authors.initials: X
authors.lastname: Wang
authors.forename: Xuelian
authors.initials: X
authors.lastname: Wang
mesh_terms: D001007:Anxiety / Q000175:diagnosis / Q000209:etiology*; D016022:Case-Control Studies; D046690:Deep Brain Stimulation / Q000009:adverse effects*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D010300:Parkinson Disease / Q000628:therapy*; D011569:Psychiatric Status Rating Scales; D012044:Regression Analysis; D020531:Subthalamic Nucleus / Q000502:physiology*; D013997:Time Factors; D016896:Treatment Outcome