title: Differential gene and microRNA expression between etoposide resistant and etoposide sensitive MCF7 breast cancer cell lines.
abstract: In order to develop targeted strategies for combating drug resistance it is essential to understand it's basic molecular mechanisms. In an exploratory study we have found several possible indicators of etoposide resistance operating in MCF7VP cells, including up-regulation of ABC transporter genes, modulation of miRNA, and alteration in copy numbers of genes.
authors.affiliation: Laboratory of Experimental Immunology, Cancer and Inflammation Program, Frederick National Laboratory for Cancer Research, Frederick, Maryland, USA.
authors.forename: Karobi
authors.initials: K
authors.lastname: Moitra
authors.forename: Kate
authors.initials: K
authors.lastname: Im
authors.forename: Katy
authors.initials: K
authors.lastname: Limpert
authors.forename: Alexander
authors.initials: A
authors.lastname: Borsa
authors.forename: Julie
authors.initials: J
authors.lastname: Sawitzke
authors.forename: Rob
authors.initials: R
authors.lastname: Robey
authors.forename: Naoya
authors.initials: N
authors.lastname: Yuhki
authors.forename: Ram
authors.initials: R
authors.lastname: Savan
authors.forename: Da Wei
authors.initials: da W
authors.lastname: Huang
authors.forename: Richard A
authors.initials: RA
authors.lastname: Lempicki
authors.forename: Susan
authors.initials: S
authors.lastname: Bates
authors.forename: Michael
authors.initials: M
authors.lastname: Dean
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000494:pharmacology*; D001943:Breast Neoplasms / Q000188:drug therapy* / Q000235:genetics* / Q000378:metabolism; D019008:Drug Resistance, Neoplasm / Q000235:genetics; D005047:Etoposide / Q000494:pharmacology*; D005260:Female; D018628:Gene Dosage; D020869:Gene Expression Profiling; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D061986:MCF-7 Cells; D035683:MicroRNAs / Q000235:genetics; D027425:ATP-Binding Cassette, Sub-Family C Proteins / Q000235:genetics / Q000378:metabolism; D009363:Neoplasm Proteins / Q000235:genetics* / Q000378:metabolism
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D005047:Etoposide; D035683:MicroRNAs; D027425:ATP-Binding Cassette, Sub-Family C Proteins; D009363:Neoplasm Proteins; C102029:ABCC6 protein, human; C421109:multidrug resistance-associated protein 1