title: Nanomechanical identification of proteins using microcantilever-based chemical sensors.
abstract: We have developed a microcantilever based sensor array which can be functionalized with mercapto-compounds to detect proteins. Linear discriminant analysis (LDA) is used to differentiate the cantilever deflection patterns. It is concluded that more sensors give better separating capacity and the COOH and Si-OCH(3) groups are important factors in protein recognition.
authors.affiliation: Laboratory of Physical Biology, Shanghai Institute of Applied Physics, Chinese Academy of Sciences, Shanghai 201800, China.
authors.forename: Ping
authors.initials: P
authors.lastname: Wang
authors.forename: Hao
authors.initials: H
authors.lastname: Pei
authors.forename: Ying
authors.initials: Y
authors.lastname: Wan
authors.forename: Jiang
authors.initials: J
authors.lastname: Li
authors.forename: Xinhua
authors.initials: X
authors.lastname: Zhu
authors.forename: Yan
authors.initials: Y
authors.lastname: Su
authors.forename: Chunhai
authors.initials: C
authors.lastname: Fan
authors.forename: Qing
authors.initials: Q
authors.lastname: Huang
mesh_terms: D015374:Biosensing Techniques; D016002:Discriminant Analysis; D036103:Nanotechnology; D011506:Proteins / Q000032:analysis*; D013438:Sulfhydryl Compounds / Q000737:chemistry*
chemical_list: D011506:Proteins; D013438:Sulfhydryl Compounds