title: Serial changes in glucose-loaded 18F-fluoro-2-deoxyglucose positron emission tomography, 99mTc-tetrofosmin and 123I-beta-methyl-p-iodophenyl-penta-decanoic acid myocardial single-photon emission computed tomography images in patients with anterior acute myocardial infarction.
abstract: BACKGROUND
  (18)F-fluoro-2-deoxyglucose (FDG) positron emission tomography (PET) is assumed to be the most useful method for evaluating the viability of the myocardium. However, there are few reports regarding serial changes in (18)F-FDG-PET images of acute myocardial infarction (AMI). We evaluated serial changes in glucose-loaded (18)F-FDG-PET, (123)I-β-methyl-p-iodophenyl-penta-decanoic acid (BMIPP) single-photon emission computed tomography (SPECT) and (99m)Tc-Tetrofosmin (TF) gated SPECT images in patients with AMI.
  
  
  RESULTS
  We enrolled 7 consecutive patients with first anterior AMI who successfully underwent percutaneous coronary intervention (PCI). (18)F-FDG-PET images were obtained in the acute, subacute, chronic, mid-term and long-term phases. (123)I-BMIPP and (99m)Tc-TF SPECT images were obtained in the subacute, chronic, mid-term and long-term phases. We determined the total defect score (TDS) for each image. The TDS of the glucose-loaded (18)F-FDG-PET, (123)I-BMIPP and( 99m)Tc-TF SPECT images indicated significant serial decrease (P<0.001). Comparing these images, the TDS of the glucose-loaded (18)F-FDG-PET images was larger than that of the (123)I-BMIPP and (99m)Tc-TF SPECT images, and the TDS indicated (18)F-FDG-PET>(123)I-BMIPP>(99m)Tc-TF in all phases.
  
  
  CONCLUSIONS
  The defect areas of glucose-loaded (18)F-FDG-PET images were significantly larger than those of (123)I-BMIPP and( 99m)Tc-TF SPECT images during 9 months follow-up of patients with successful PCI for anterior AMI. Additionally, the impairment of glucose metabolism was prolonged.
authors.affiliation: Department of Cardiology, Kanazawa Cardiovascular Hospital, Kanazawa, Japan. mm970076ryota2000@yahoo.co.jp
authors.forename: Ryota
authors.initials: R
authors.lastname: Fukuoka
authors.forename: Yuki
authors.initials: Y
authors.lastname: Horita
authors.forename: Masanobu
authors.initials: M
authors.lastname: Namura
authors.forename: Masatoshi
authors.initials: M
authors.lastname: Ikeda
authors.forename: Hidenobu
authors.initials: H
authors.lastname: Terai
authors.forename: Naoto
authors.initials: N
authors.lastname: Tama
authors.forename: Toshimitsu
authors.initials: T
authors.lastname: Takagi
authors.forename: Hisashi
authors.initials: H
authors.lastname: Bunko
mesh_terms: D000368:Aged; D005227:Fatty Acids / Q000008:administration & dosage*; D005260:Female; D019788:Fluorodeoxyglucose F18 / Q000008:administration & dosage*; D005500:Follow-Up Studies; D006801:Humans; D007462:Iodobenzenes / Q000008:administration & dosage*; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000000981:diagnostic imaging* / Q000628:therapy; D009943:Organophosphorus Compounds; D015609:Organotechnetium Compounds; D062645:Percutaneous Coronary Intervention; D049268:Positron-Emission Tomography; D011859:Radiography; D019275:Radiopharmaceuticals / Q000008:administration & dosage*; D015899:Tomography, Emission-Computed, Single-Photon
chemical_list: D005227:Fatty Acids; D007462:Iodobenzenes; D009943:Organophosphorus Compounds; D015609:Organotechnetium Compounds; D019275:Radiopharmaceuticals; C049338:iodofiltic acid; D019788:Fluorodeoxyglucose F18; C078700:technetium tc-99m tetrofosmin