title: Immune functions of the garment workers.
abstract: BACKGROUND
  Occupational exposure to cotton dust, fibers, metal fumes and different chemicals used in the aparrel manufacturing industries cause a wide range of physical and psychological health problems in the garment workers that may also affect their immune function.
  
  
  OBJECTIVE
  To assess the immune system function in garment workers.
  
  
  METHODS
  A total of 45 workers of a garment factory, and 41 control subjects, not exposed to the garment working environment were enrolled in this study. In the study subjects, the complement system function was assessed as bactericidal activity on Escherichia coli DH5α cells using the standard plate count method. Serum complement components C3 and C4 were measured by immunoprecipitation, and IgG was measured by immunonephelometry.
  
  
  RESULTS
  The bactericidal activity of serum complement in the garment workers (range: 93.5%-99.9%) was significantly (p<0.01) lower than that in the controls (range: 98.6%-100%). The heat-inactivated serum of the workers showed a significantly enhanced bactericidal activity. In the garment workers, the mean levels of complement C3, and C4 were 1.75 and 0.26 g/L, respectively that were close to those of the controls. The mean IgG level in the garment workers was 13.5 g/L that was significantly (p<0.001) higher than that in the controls.
  
  
  CONCLUSIONS
  Working in a garment factory may affect the immune system.
authors.affiliation: Department of Biochemistry and Molecular Biology, University of Dhaka, Bangladesh.
authors.forename: R
authors.initials: R
authors.lastname: Sultana
authors.forename: K J
authors.initials: KJ
authors.lastname: Ferdous
authors.forename: M
authors.initials: M
authors.lastname: Hossain
authors.forename: M S H
authors.initials: MS
authors.lastname: Zahid
authors.forename: L N
authors.initials: LN
authors.lastname: Islam
mesh_terms: D000293:Adolescent; D000328:Adult; D000395:Air Pollutants, Occupational / Q000276:immunology*; D001459:Bangladesh; D001770:Blood Bactericidal Activity; D003020:Clothing; D015169:Colony Count, Microbial; D003165:Complement System Proteins / Q000378:metabolism; D004926:Escherichia coli / Q000187:drug effects; D005260:Female; D006801:Humans; D007107:Immune System / Q000187:drug effects*; D007074:Immunoglobulin G / Q000097:blood; D047468:Immunoprecipitation; D008297:Male; D009391:Nephelometry and Turbidimetry; D016273:Occupational Exposure; D013783:Textile Industry; D055815:Young Adult
chemical_list: D000395:Air Pollutants, Occupational; D007074:Immunoglobulin G; D003165:Complement System Proteins