title: [Parkinson's disease: current standards in diagnostics and therapy].
abstract: Idiopathic Parkinson's disease is still a clinical diagnosis. However, modern imaging and nuclear techniques allow very early diagnosis and lead to higher security in the differential diagnosis between idiopathic Parkinson's disease and atypical Parkinson syndromes. At early stages of the disease, modification of disease progression and symptom control are key factors of the therapy. Continuous dopaminergic stimulation is even more important at later stages with first fluctuations. In stages where conservative medical options have been exhausted continuous pump therapies with Duodopa and apomorphine are attractive options. Deep brain stimulation in the subthalamic nucleus has turned out in the last years, especially in younger patients, to be a highly successful treatment option. Deep drain stimulation requires, however, a close preoperative work-up and individual consideration of potential effects and side effects.
authors.affiliation: Klinik und Poliklinik für Neurologie, Universitätsklinikum Köln. lars.timmermann@uk-koeln.de
authors.forename: L
authors.initials: L
authors.lastname: Timmermann
authors.forename: C
authors.initials: C
authors.lastname: Eggers
authors.forename: H
authors.initials: H
authors.lastname: Salimi Dafsari
authors.forename: K A M
authors.initials: KA
authors.lastname: Pauls
authors.forename: M T
authors.initials: MT
authors.lastname: Barbe
mesh_terms: D000928:Antidepressive Agents / Q000627:therapeutic use; D000978:Antiparkinson Agents / Q000009:adverse effects / Q000627:therapeutic use; D046690:Deep Brain Stimulation; D007174:Disruptive, Impulse Control, and Conduct Disorders / Q000188:drug therapy / Q000209:etiology; D004343:Drug Implants / Q000627:therapeutic use; D020233:Gait Disorders, Neurologic / Q000209:etiology / Q000628:therapy; D006801:Humans; D007980:Levodopa / Q000627:therapeutic use; D010300:Parkinson Disease / Q000175:diagnosis* / Q000188:drug therapy / Q000523:psychology / Q000628:therapy*; D011605:Psychoses, Substance-Induced / Q000188:drug therapy; D014202:Tremor / Q000209:etiology / Q000628:therapy
chemical_list: D000928:Antidepressive Agents; D000978:Antiparkinson Agents; D004343:Drug Implants; D007980:Levodopa