title: Routine use of corticosteroids to prevent inflammation response in cardiac surgery.
abstract: Cardiac surgery, especially if it involves cardiopulmonary bypass, is associated with a severe systemic inflammatory response. It is characterized by complement activation and initiation of coagulation, fibrinolysis and kallikrein cascades. Consecutive activation of immunoregulatory cells results in an extensive release of pro- and anti-inflammatory cytokines. This inflammatory storm is related to organ dysfunction or failure and correlates with postoperative morbidity. In order to attenuate this deleterious inflammatory response in the perioperative period alternative surgical techniques, novel extracorporeal circulation devices and immunomodulatory pharmacological strategies are in focus of contemporary research. Since decades corticosteroids have been used and studied in patients undergoing cardiac surgery. Although it could be shown that glucocorticoids seem to change the pro-inflammatory cytokine profile in a favourable manner, it still remains controversial if this effect translates into a better clinical outcome. Several clinical trials have proclaimed an association between this inflammatory response and the incidence of major complications i.e, myocardial infarction and pulmonary complications, but until now they have failed to show conclusive results. This article describes the different types and recommended dose schemes of corticosteroids in the perioperative period of cardiac surgery along with the discussion of few patents. It will comment on potential side effects and review the effect on the postoperative outcome.
authors.affiliation: Department for Anaesthesiology, Ludwig-Maximilians-University Munich, Germany.
authors.forename: Tim
authors.initials: T
authors.lastname: Nebelsiek
authors.forename: Andres
authors.initials: A
authors.lastname: Beiras-Fernandez
authors.forename: Erich
authors.initials: E
authors.lastname: Kilger
authors.forename: Patrick
authors.initials: P
authors.lastname: Möhnle
authors.forename: Florian
authors.initials: F
authors.lastname: Weis
mesh_terms: D000305:Adrenal Cortex Hormones / Q000009:adverse effects / Q000627:therapeutic use*; D000893:Anti-Inflammatory Agents / Q000009:adverse effects / Q000627:therapeutic use*; D006348:Cardiac Surgical Procedures / Q000009:adverse effects / Q000379:methods*; D002315:Cardiopulmonary Bypass / Q000009:adverse effects; D006801:Humans; D059035:Perioperative Period / Q000379:methods; D011183:Postoperative Complications / Q000517:prevention & control; D018746:Systemic Inflammatory Response Syndrome / Q000517:prevention & control*
chemical_list: D000305:Adrenal Cortex Hormones; D000893:Anti-Inflammatory Agents