title: Darunavir is a good third-line antiretroviral agent for HIV type 1-infected patients failing second-line protease inhibitor-based regimens in South India.
abstract: Eleven protease mutations have been associated with reduced susceptibility to darunavir. In this study of 87 HIV-1-infected patients experiencing virological failure to second-line regimens containing protease inhibitors boosted with ritonavir (viral load >1,000 HIV RNA copies/ml), we observed a low prevalence (3%) of ≥3 darunavir resistance-associated mutations, indicating that this drug may be a good option for third-line antiretroviral therapy in southern India.
authors.affiliation: YRG Centre for AIDS Research and Education, Chennai, India. saravanan@yrgcare.org
authors.forename: Shanmugam
authors.initials: S
authors.lastname: Saravanan
authors.forename: Vidya
authors.initials: V
authors.lastname: Madhavan
authors.forename: Pachamuthu
authors.initials: P
authors.lastname: Balakrishnan
authors.forename: Davey M
authors.initials: DM
authors.lastname: Smith
authors.forename: Sunil Suhas
authors.initials: SS
authors.lastname: Solomon
authors.forename: Sathasivam
authors.initials: S
authors.lastname: Sivamalar
authors.forename: Selvamuthu
authors.initials: S
authors.lastname: Poongulali
authors.forename: Nagalingeswaran
authors.initials: N
authors.lastname: Kumarasamy
authors.forename: Robert T
authors.initials: RT
authors.lastname: Schooley
authors.forename: Suniti
authors.initials: S
authors.lastname: Solomon
authors.forename: Rami
authors.initials: R
authors.lastname: Kantor
mesh_terms: D019380:Anti-HIV Agents / Q000627:therapeutic use*; D003430:Cross-Sectional Studies; D000069454:Darunavir; D024882:Drug Resistance, Viral; D015658:HIV Infections / Q000188:drug therapy* / Q000821:virology*; D016333:HIV Protease / Q000235:genetics; D017320:HIV Protease Inhibitors / Q000627:therapeutic use; D015497:HIV-1 / Q000187:drug effects* / Q000302:isolation & purification; D006801:Humans; D007194:India; D020125:Mutation, Missense; D013449:Sulfonamides / Q000627:therapeutic use*
chemical_list: D019380:Anti-HIV Agents; D017320:HIV Protease Inhibitors; D013449:Sulfonamides; D016333:HIV Protease; D000069454:Darunavir