title: Growth hormone deficiency and diabetes insipidus as a complication of endoscopic third ventriculostomy.
abstract: Endoscopic third ventriculostomy (ETV) has become the procedure of choice for the treatment of obstructive hydrocephalus in children and adults. Endocrinological complications of ETV in children are rare. Diabetes insipidus (DI) is the most common and accounts for only 0.5% of complications from ETV. The majority of documented cases are transient. To date, there are no documented cases of multiple pituitary hormone deficiencies. We present here a 6-year-old girl with growth hormone deficiency and permanent DI which developed as a complication of ETV. This patient is unique in both demonstrating multiple pituitary hormone deficiencies and the classical triphasic response of DI after ETV. We postulate that these complications were caused by compression of the pituitary stalk and hypothalamic injury during the procedure. We compare our case presentation to experimental studies conducted in rats.
authors.affiliation: Stony Brook University, Department of Pediatrics, Stony Brook Childrens Hospital, Division of Pediatric Endocrinology, Stony Brook, NY, U.S.A. Kimberly.Tafuri@stonybrookmedicine.edu
authors.forename: Kimberly S
authors.initials: KS
authors.lastname: Tafuri
authors.forename: Thomas A
authors.initials: TA
authors.lastname: Wilson
mesh_terms: D002648:Child; D002657:Child Development; D003919:Diabetes Insipidus / Q000209:etiology* / Q000628:therapy; D005260:Female; D019382:Human Growth Hormone / Q000172:deficiency*; D006801:Humans; D006849:Hydrocephalus / Q000601:surgery; D044583:Neuroendoscopy / Q000009:adverse effects*; D020542:Third Ventricle / Q000601:surgery*; D016896:Treatment Outcome; D014696:Ventriculostomy / Q000009:adverse effects*
chemical_list: D019382:Human Growth Hormone