title: Graham-Little Piccardi Lassueur syndrome: case report.
abstract: A 33-year-old woman presented with a 3-year history of progressive alopecia of the scalp. Past treatment with hydroxicloroquine did not show improvement. Physical examination revealed multiple areas of alopecia with atrophic aspect of the scalp, and axillary and pubic hypotrichosis. Dermoscopy showed hyperkeratosis and accentuation of follicular ostia. Anatomopathological examination revealed decrease in the number of hair follicles, upper perifollicular infiltrate and areas with fibrosis. The Piccardi-Lassueur-Graham-Little syndrome is a rare disorder, characterized by the triad of multifocal scarring alopecia of the scalp, keratotic follicular eruption and hypotrichosis of axillary and pubic regions. Management is a challenge and many medications tried have controversial results. We report a case of this rare syndrome which improved with corticoids.
authors.affiliation: Dermatology Service, Charity Hospital of Porto Alegre, RS, Brazil. raquelsteglich@yahoo.com.br
authors.forename: Raquel Bissacotti
authors.initials: RB
authors.lastname: Steglich
authors.forename: Renata Elise
authors.initials: RE
authors.lastname: Tonoli
authors.forename: Giselle Martins
authors.initials: GM
authors.lastname: Pinto
authors.forename: Fernanda Melo
authors.initials: FM
authors.lastname: Müller
authors.forename: Isabelle Maffei
authors.initials: IM
authors.lastname: Guarenti
authors.forename: Ernani Siegmann
authors.initials: ES
authors.lastname: Duvelius
mesh_terms: D000328:Adult; D000505:Alopecia / Q000473:pathology*; D002921:Cicatrix / Q000473:pathology*; D046169:Dermoscopy; D005260:Female; D006801:Humans; D007039:Hypotrichosis / Q000175:diagnosis; D007642:Keratosis / Q000473:pathology; D012535:Scalp / Q000473:pathology*; D013577:Syndrome