title: Mineralocorticoid before glucocorticoid deficiency in a dog with primary hypoadrenocorticism and hypothyroidism.
abstract: A dog with an unexpected presentation of primary hypoadrenocorticism was evaluated for clinical signs and electrolyte abnormalities characteristic of Addison's disease. Although the initial adrenocorticotropic hormone (ACTH) stimulation test documented serum cortisol concentrations within the reference range, subsequent assessments confirmed hypoaldosteronism. Mineralocorticoid replacement promptly normalized electrolytes and transiently improved clinical illness. Six weeks after initial ACTH stimulation testing, the dog became glucocorticoid deficient. Concurrent primary hypothyroidism was also documented. Hypoaldosteronism preceding hypocortisolemia is a unique presentation of canine Addison's disease.
authors.affiliation: Department of Clinical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY, USA. katie_mcgonigle@hotmail.com
authors.forename: Kathryn M
authors.initials: KM
authors.lastname: McGonigle
authors.forename: John F
authors.initials: JF
authors.lastname: Randolph
authors.forename: Sharon A
authors.initials: SA
authors.lastname: Center
authors.forename: Richard E
authors.initials: RE
authors.lastname: Goldstein
mesh_terms: D000224:Addison Disease / Q000097:blood / Q000175:diagnosis / Q000662:veterinary*; D000304:Adrenal Cortex Function Tests / Q000662:veterinary; D000324:Adrenocorticotropic Hormone / Q000097:blood*; D000818:Animals; D004283:Dog Diseases / Q000097:blood* / Q000175:diagnosis; D004285:Dogs; D005938:Glucocorticoids / Q000097:blood / Q000172:deficiency*; D006854:Hydrocortisone / Q000097:blood; D007037:Hypothyroidism / Q000097:blood / Q000175:diagnosis / Q000662:veterinary*; D008297:Male
chemical_list: D005938:Glucocorticoids; D000324:Adrenocorticotropic Hormone; D006854:Hydrocortisone