title: Peptides as targeting probes against tumor vasculature for diagnosis and drug delivery.
abstract: Tumor vasculature expresses a distinct set of molecule signatures on the endothelial cell surface different from the resting blood vessels of other organs and tissues in the body. This makes them an attractive target for cancer therapy and molecular imaging. The current technology using the in vivo phage display biopanning allows us to quickly isolate and identify peptides potentially homing to various tumor blood vessels. Tumor-homing peptides in conjugation with chemotherapeutic drugs or imaging contrast have been extensively tested in various preclinical and clinical studies. These tumor-homing peptides have valuable potential as targeting probes for tumor molecular imaging and drug delivery. In this review, we summarize the recent advances about the applications of tumor-homing peptides selected by in vivo phage display library screening against tumor vasculature. We also introduce the characteristics of the latest discovered tumor-penetrating peptides in their potential clinical applications.
authors.affiliation: School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong SAR. chcho@cuhk.edu.hk.
authors.forename: Zhi Jie
authors.initials: ZJ
authors.lastname: Li
authors.forename: Chi Hin
authors.initials: CH
authors.lastname: Cho
mesh_terms: D000818:Animals; D016503:Drug Delivery Systems; D006801:Humans; D057054:Molecular Imaging; D009369:Neoplasms / Q000098:blood supply / Q000175:diagnosis* / Q000188:drug therapy*; D009389:Neovascularization, Pathologic / Q000188:drug therapy*; D019151:Peptide Library; D010455:Peptides / Q000627:therapeutic use*
chemical_list: D019151:Peptide Library; D010455:Peptides