title: Interleukin-19 and interleukin-22 serum levels are decreased in patients with ovarian endometrioma.
abstract: OBJECTIVE
  To determine the serum levels of interleukin (IL)-10 family ILs in women with ovarian endometriosis and investigate the correlation of these levels with disease activity.
  
  
  METHODS
  A case-control laboratory study.
  
  
  METHODS
  Tertiary-care university hospital.
  
  
  METHODS
  Two hundred nineteen women, with (n = 112) and without (n = 107) endometriosis.
  
  
  METHODS
  Complete surgical excision with pathological analysis.
  
  
  METHODS
  Blood samples were obtained during surgical procedures. IL-10, -19, -20, and -22 were assayed by ELISA in sera, and the concentrations correlated with the extent and the severity of the disease.
  
  
  RESULTS
  IL-19 was detectable in 18.3% and IL-22 in 47.9% of sera samples from all 219 women studied. Serum IL-19 was lower in women with endometriosis (median, 292.7 pg/mL; range, 32.2-1,339.3) than in endometriosis-free women (median, 1,035.8 pg/mL; range, 32.2-2,000.0). In addition, serum IL-22 levels were decreased in women affected by endometriosis (median, 352.0 pg/mL; range, 31.2-1,392.2) as compared with endometriosis-free women (median, 709.2 pg/mL; range, 73.3-2,012.0). We found significant correlations between serum IL-22 concentrations and intensity of deep dyspareunia (r = -0.303) and noncyclic chronic pelvic pain (r = -0.212). IL-19 was correlated with the intensity of deep dyspareunia (r = -0.749).
  
  
  CONCLUSIONS
  Serum IL-19 and IL-22 are decreased in women with ovarian endometrioma. IL-10 family ILs may be involved in the pathogenesis of endometriosis.
authors.affiliation: Department of Gynecology Obstetrics II and Reproductive Medicine, Assistance publique-Hôpitaux de Paris, Hôpital Cochin, Laboratory of Biochemistry, Université Paris Descartes, Sorbonne Paris Cité, Paris, France; Hôpital Cochin, Laboratoire d'immunologie, Assistance publique-Hôpitaux de Paris, Hôpital Cochin, Laboratory of Biochemistry, Université Paris Descartes, Sorbonne Paris Cité, Paris, France; Faculté de Médecine, Inserm, Institut Cochin, Centre National de la Recherche Scientifique, Université Paris Descartes, Sorbonne Paris Cité, Paris, France. Electronic address: pietro.santulli@inserm.fr.
authors.forename: Pietro
authors.initials: P
authors.lastname: Santulli
authors.affiliation: Department of Gynecology Obstetrics II and Reproductive Medicine, Assistance publique-Hôpitaux de Paris, Hôpital Cochin, Laboratory of Biochemistry, Université Paris Descartes, Sorbonne Paris Cité, Paris, France; Faculté de Médecine, Inserm, Institut Cochin, Centre National de la Recherche Scientifique, Université Paris Descartes, Sorbonne Paris Cité, Paris, France.
authors.forename: Bruno
authors.initials: B
authors.lastname: Borghese
authors.affiliation: Hôpital Cochin, Laboratoire d'immunologie, Assistance publique-Hôpitaux de Paris, Hôpital Cochin, Laboratory of Biochemistry, Université Paris Descartes, Sorbonne Paris Cité, Paris, France.
authors.forename: Sandrine
authors.initials: S
authors.lastname: Chouzenoux
authors.affiliation: Department of Gynecology Obstetrics II and Reproductive Medicine, Assistance publique-Hôpitaux de Paris, Hôpital Cochin, Laboratory of Biochemistry, Université Paris Descartes, Sorbonne Paris Cité, Paris, France; Hôpital Cochin, Laboratoire d'immunologie, Assistance publique-Hôpitaux de Paris, Hôpital Cochin, Laboratory of Biochemistry, Université Paris Descartes, Sorbonne Paris Cité, Paris, France.
authors.forename: Isabelle
authors.initials: I
authors.lastname: Streuli
authors.affiliation: Faculté de Médecine, Assistance publique-Hôpitaux de Paris, Hôpital Cochin, Laboratory of Biochemistry, Université Paris Descartes, Sorbonne Paris Cité, Paris, France.
authors.forename: Didier
authors.initials: D
authors.lastname: Borderie
authors.affiliation: Department of Gynecology Obstetrics II and Reproductive Medicine, Assistance publique-Hôpitaux de Paris, Hôpital Cochin, Laboratory of Biochemistry, Université Paris Descartes, Sorbonne Paris Cité, Paris, France.
authors.forename: Dominique
authors.initials: D
authors.lastname: de Ziegler
authors.affiliation: Hôpital Cochin, Laboratoire d'immunologie, Assistance publique-Hôpitaux de Paris, Hôpital Cochin, Laboratory of Biochemistry, Université Paris Descartes, Sorbonne Paris Cité, Paris, France.
authors.forename: Bernard
authors.initials: B
authors.lastname: Weill
authors.affiliation: Department of Gynecology Obstetrics II and Reproductive Medicine, Assistance publique-Hôpitaux de Paris, Hôpital Cochin, Laboratory of Biochemistry, Université Paris Descartes, Sorbonne Paris Cité, Paris, France; Hôpital Cochin, Laboratoire d'immunologie, Assistance publique-Hôpitaux de Paris, Hôpital Cochin, Laboratory of Biochemistry, Université Paris Descartes, Sorbonne Paris Cité, Paris, France; Faculté de Médecine, Inserm, Institut Cochin, Centre National de la Recherche Scientifique, Université Paris Descartes, Sorbonne Paris Cité, Paris, France.
authors.forename: Charles
authors.initials: C
authors.lastname: Chapron
authors.affiliation: Hôpital Cochin, Laboratoire d'immunologie, Assistance publique-Hôpitaux de Paris, Hôpital Cochin, Laboratory of Biochemistry, Université Paris Descartes, Sorbonne Paris Cité, Paris, France.
authors.forename: Frederic
authors.initials: F
authors.lastname: Batteux
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D004715:Endometriosis / Q000097:blood* / Q000503:physiopathology; D005260:Female; D006801:Humans; D016753:Interleukin-10 / Q000097:blood; D007378:Interleukins / Q000097:blood*; D010049:Ovarian Diseases / Q000097:blood* / Q000503:physiopathology; D012189:Retrospective Studies; D012720:Severity of Illness Index; D000097043:Interleukin-22
chemical_list: D016753:Interleukin-10; D007378:Interleukins; D000097043:Interleukin-22; C421250:IL19 protein, human; C422042:interleukin 20