title: Biological effects of static electric field: Plasma/serum proteome analysis of rats.
abstract: The external static electric field (SEF) of man-made origin brings to the substantially increased SEF background in a human environment the biological activity of which is a moot question. The paper reports on rats blood plasma/serum proteome modifications by means of 1D polyacrilamide gel electrophoresis and clotting process alterations after the short- and long-term SEF exposures of 200 kV/m. The results indicate decrease of fast α1 and α2 globular proteins in plasma coinciding with clotting acceleration after the short-term SEF, and attenuation of clotting-dependent proteome modifications reflected with incomplete coagulation after the long-term SEF exposure. Increased lysozyme activity in serum unlike plasma was observed after both SEF exposures. Applied model of the high-voltage SEF environment indicates dependence of biological systems functioning on the external SEF.
authors.affiliation: Scientific-Research Centre, Laboratory of Biochemical and Biophysical Research, Yerevan State Medical University After Mkhitar Heratsi, Yerevan, Armenia. hayk@web.am
authors.forename: Hayk
authors.initials: H
authors.lastname: Harutyunyan
authors.forename: Gagik
authors.initials: G
authors.lastname: Artsruni
mesh_terms: D000818:Animals; D001777:Blood Coagulation; D001798:Blood Proteins / Q000302:isolation & purification / Q000378:metabolism*; D004560:Electricity / Q000009:adverse effects*; D004586:Electrophoresis; D005260:Female; D005337:Fibrin / Q000302:isolation & purification / Q000378:metabolism; D005340:Fibrinogen / Q000302:isolation & purification / Q000378:metabolism; D009113:Muramidase / Q000097:blood / Q000302:isolation & purification; D040901:Proteomics; D051381:Rats
chemical_list: D001798:Blood Proteins; D005337:Fibrin; D005340:Fibrinogen; D009113:Muramidase