title: Risk factors for No. 12p and No. 12b lymph node metastases in advanced gastric cancer in China.
abstract: BACKGROUND
  The risk factors for No. 12p and No. 12b lymph node (LN) metastases in advanced gastric cancer (GC) remain controversial. The aim of this study was to investigate the risk factors for No. 12p and No. 12b LN metastases in advanced GC.
  
  
  METHODS
  From January 1999 to December 2005, a retrospective analysis of 163 patients with advanced GC who underwent D2 lymphadenectomy in addition to No. 12p and No. 12b LN dissections was conducted. Potential clinicopathological factors that could influence No. 12p and No. 12b LN metastases were statistically analyzed.
  
  
  RESULTS
  There were 15 cases (9.2%) with No. 12p LN metastases and 5 cases (3.1%) with synchronous No. 12b LN metastases. A logistic regression analysis revealed that the Borrmann type (III/IV versus I/II, P = 0.029), localization (lesser/circular versus greater, P = 0.025), and depth of invasion (pT4 versus pT2/pT3, P = 0.009) were associated with 11.1-, 3.8-, and 5.6-fold increases, respectively, for risk of No. 12p and No. 12b LN metastases. A logistic regression analysis also showed that No. 5 (P = 0.006) and No. 12a (P = 0.004) LN metastases were associated with 6.9- and 11.3-fold increases, respectively, for risk of No. 12p and No. 12b LN metastases. In addition, significant differences in 5-year survival of patients with and without No. 12p and No. 12b LN metastases were observed (13.3% versus 35.1%, P = 0.022).
  
  
  CONCLUSIONS
  We conclude that Borrmann type, localization, and depth of invasion are significant variables for identifying patients with No. 12p and No. 12b LN metastases. Individuals with No. 5 or No. 12a LN metastases should be on high alert for the possibility of additional metastases to the No. 12p and No. 12b LNs.
authors.affiliation: Department of Oncological Surgery, Zhejiang Cancer Hospital, Hangzhou, People's Republic of China.
authors.forename: Ji-Feng
authors.initials: JF
authors.lastname: Feng
authors.forename: Ying
authors.initials: Y
authors.lastname: Huang
authors.forename: Jing
authors.initials: J
authors.lastname: Liu
authors.forename: Huang
authors.initials: H
authors.lastname: Liu
authors.forename: Hua-Ying
authors.initials: HY
authors.lastname: Sheng
authors.forename: Wei-Tian
authors.initials: WT
authors.lastname: Wei
authors.forename: Wei-Shan
authors.initials: WS
authors.lastname: Lu
authors.forename: Da-Feng
authors.initials: DF
authors.lastname: Chen
authors.forename: Wen-You
authors.initials: WY
authors.lastname: Chen
authors.forename: Xing-Ming
authors.initials: XM
authors.lastname: Zhou
mesh_terms: D000328:Adult; D000368:Aged; D002681:China; D005260:Female; D006801:Humans; D016015:Logistic Models; D008197:Lymph Node Excision; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D012307:Risk Factors; D013274:Stomach Neoplasms / Q000401:mortality / Q000473:pathology* / Q000601:surgery; D015996:Survival Rate