title: Prevalence of raised intracranial pressure in cerebral malaria detected by optic nerve sheath ultrasound.
abstract: We aimed to use optic nerve sheath (ONS) ultrasound to determine the prevalence of raised intracranial pressure (ICP) in African children with cerebral malaria (CM); and if increased ONS diameter is associated with poor outcome. We measured ONS diameter in 101 children with CM and 11 children with malaria and impaired consciousness in Malawi. The prevalence of raised ICP detected by increased ONS diameter was 49%. Case fatality was similar in children with increased ONS diameter on admission (9/55) and those children without increased ONS diameter (11/57). Neurological sequelae were more common in those children with increased ONS diameter (7/46 versus 2/46, P < 0.05). Lumbar puncture (LP) opening pressure was elevated in 95% of 46 children who underwent LP. In Malawian children with CM, raised ICP is less commonly detected by ONS ultrasound than LP. This study suggests that raised ICP is not universal in CM and that other mechanisms may account for coma.
authors.affiliation: St. Paul's Eye Unit, Royal Liverpool University Hospital, Liverpool, United Kingdom. nbeare@btinternet.com
authors.forename: Nicholas A V
authors.initials: NA
authors.lastname: Beare
authors.forename: Simon J
authors.initials: SJ
authors.lastname: Glover
authors.forename: Susan
authors.initials: S
authors.lastname: Lewallen
authors.forename: Terrie E
authors.initials: TE
authors.lastname: Taylor
authors.forename: Simon P
authors.initials: SP
authors.lastname: Harding
authors.forename: Malcolm E
authors.initials: ME
authors.lastname: Molyneux
mesh_terms: D002675:Child, Preschool; D005260:Female; D006801:Humans; D019586:Intracranial Hypertension / Q000175:diagnosis*; D007630:Kenya / Q000453:epidemiology; D016779:Malaria, Cerebral / Q000453:epidemiology / Q000473:pathology*; D008297:Male; D009900:Optic Nerve / Q000000981:diagnostic imaging*; D014463:Ultrasonography