title: Virgin coconut oil supplementation prevents bone loss in osteoporosis rat model.
abstract: Oxidative stress and free radicals have been implicated in the pathogenesis of osteoporosis. Therefore, antioxidant compounds have the potential to be used in the prevention and treatment of the disease. In this study, we investigated the effects of virgin coconut oil (VCO) on bone microarchitecture in a postmenopausal osteoporosis rat model. VCO is a different form of coconut oil as it is rich with antioxidants. Three-month-old female rats were randomly grouped into baseline, sham-operated, ovariectomized control (Ovx), and ovariectomized rats fed with 8% VCO in their diet for six weeks (Ovx+VCO). Bone histomorphometry of the right femora was carried out at the end of the study. Rats supplemented with VCO had a significantly greater bone volume and trabecular number while trabecular separation was lower than the Ovx group. In conclusion, VCO was effective in maintaining bone structure and preventing bone loss in estrogen-deficient rat model.
authors.affiliation: Pharmacology Department, Faculty of Medicine, Universiti Kebangsaan Malaysia, 50300 Kuala Lumpur, Malaysia.
authors.forename: Zil
authors.initials: Z
authors.lastname: Hayatullina
authors.forename: Norliza
authors.initials: N
authors.lastname: Muhammad
authors.forename: Norazlina
authors.initials: N
authors.lastname: Mohamed
authors.forename: Ima-Nirwana
authors.initials: IN
authors.lastname: Soelaiman