title: Late hypersensitivity to omeprazole and other proton pump inhibitors.
abstract: A 63 year-old woman presented with a persistent, red, papular, itching skin eruption localised on the face, right shoulder and the right upper member. The evolution was longer than ten years with a permanent progressive diffuse facial burning sensation and unaesthetic aspect despite topical antibiotic and anti-inflammatory treatments. The clinical and the histological diagnosis corresponded to prurigo. She was treated by omeprazole for gastric reflux since more than ten years, and she had a viral C hepatitis. The relationship between prurigo and omeprazole was evidenced by the complete resolution of symptoms after the drug's interruption and the recurrence after the omeprazole re-introduction. The immediate and late skin tests were negative for the tested drugs. Clinical cross-reactivity was observed with pantoprazole and lansoprazole; this suggested a late hypersensitivity to drugs of the proton pump inhibitors class. To our knowledge, it is the first case of prurigo induced by these drugs.
authors.affiliation: Chest Unit, Department of Internal Medicine, Cliniques Universitaires Saint-Luc, Brussels, Belgium. Francoise.Pirson@uclouvain.be
authors.forename: F
authors.initials: F
authors.lastname: Pirson
authors.forename: A
authors.initials: A
authors.lastname: Geubel
authors.forename: L
authors.initials: L
authors.lastname: Marot
mesh_terms: D003429:Cross Reactions; D003875:Drug Eruptions / Q000175:diagnosis / Q000209:etiology; D004342:Drug Hypersensitivity / Q000175:diagnosis* / Q000209:etiology; D005260:Female; D006801:Humans; D008875:Middle Aged; D009853:Omeprazole / Q000009:adverse effects*; D054328:Proton Pump Inhibitors / Q000009:adverse effects*
chemical_list: D054328:Proton Pump Inhibitors; D009853:Omeprazole