title: DNA damage: placing BRCA1 in the proper context.
abstract: How does BRCA1's evolutionarily conserved E3 ligase activity contribute to DNA damage responses? Genetically engineered cells containing a BRCA1 RING domain mutation have been used to identify Claspin as a new target of BRCA1 E3 ligase activity in response to specific forms of DNA damage.
authors.affiliation: Department of Cancer Biology, University of Pennsylvania, 421 Curie Blvd, Philadelphia, PA, USA.
authors.forename: Bernadette
authors.initials: B
authors.lastname: Aressy
authors.forename: Roger A
authors.initials: RA
authors.lastname: Greenberg
mesh_terms: D048868:Adaptor Proteins, Signal Transducing / Q000378:metabolism*; D019313:BRCA1 Protein / Q000378:metabolism*; D000071877:Checkpoint Kinase 1; D004249:DNA Damage; D004260:DNA Repair; D006801:Humans; D011494:Protein Kinases / Q000378:metabolism*; D044767:Ubiquitin-Protein Ligases / Q000378:metabolism*
chemical_list: D048868:Adaptor Proteins, Signal Transducing; D019313:BRCA1 Protein; C488158:CLSPN protein, human; D044767:Ubiquitin-Protein Ligases; D011494:Protein Kinases; D000071877:Checkpoint Kinase 1