title: High frequency mechanical ventilation affects respiratory system mechanics differently in C57BL/6J and BALB/c adult mice.
abstract: We tested the hypothesis that high frequency ventilation affects respiratory system mechanical functions in C57BL/6J and BALB/c mice. We measured respiratory mechanics by the forced oscillation technique over 1h in anesthetized, intubated, ventilated BALB/c and C57BL/6J male mice. We did not detect any change in airway resistance, Rn, tissue damping, G, tissue elastance, H and hysteresivity, eta in BALB/c mice during 1h of ventilation at 150 or at 450 breaths/min; nor did we find a difference between BALB/c mice ventilated at 150 breaths/min compared with 450 breaths/min. Among C57BL/6J mice, except for H, all parameters remained unchanged over 1h of ventilation in mice ventilated at 150 breaths/min. However, after 10 and 30 min of ventilation at 450 breaths/min, Rn, and respiratory system compliance were lower, and eta was higher, than their starting value. We conclude that high frequency mechanical ventilation affects respiratory system mechanics differently in C57BL/6J and BALB/c adult mice.
authors.affiliation: Georgetown University School of Medicine, 3900 Reservoir Rd, NW Washington, DC 20057-1481, United States. hlhadden@yahoo.com
authors.forename: Hélène
authors.initials: H
authors.lastname: Hadden
mesh_terms: D000403:Airway Resistance / Q000502:physiology; D000704:Analysis of Variance; D000818:Animals; D004548:Elasticity / Q000502:physiology; D006612:High-Frequency Ventilation / Q000009:adverse effects*; D008170:Lung Compliance / Q000235:genetics; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D011175:Positive-Pressure Respiration; D015656:Respiratory Mechanics / Q000235:genetics* / Q000502:physiology; D012137:Respiratory System; D013045:Species Specificity; D055397:Ventilator-Induced Lung Injury / Q000209:etiology* / Q000235:genetics