title: Conosilane A, an unprecedented sesquiterpene from the cultures of basidiomycete Conocybe siliginea.
abstract: Conosilane A (1), a novel sesquiterpene with an unprecedented carbon skeleton, was isolated from the cultures of the basidiomycete Conocybe siliginea. Its structure was elucidated by extensive spectroscopic methods, and the absolute configuration was determined by single crystal X-ray diffraction analysis. Conosilane A was found to inhibit 11β-hydroxysteroid dehydrogenase significantly.
authors.affiliation: State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, PR China.
authors.forename: Xiao-Yan
authors.initials: XY
authors.lastname: Yang
authors.forename: Tao
authors.initials: T
authors.lastname: Feng
authors.forename: Zheng-Hui
authors.initials: ZH
authors.lastname: Li
authors.forename: Yu
authors.initials: Y
authors.lastname: Sheng
authors.forename: Xia
authors.initials: X
authors.lastname: Yin
authors.forename: Ying
authors.initials: Y
authors.lastname: Leng
authors.forename: Ji-Kai
authors.initials: JK
authors.lastname: Liu
mesh_terms: D042842:11-beta-Hydroxysteroid Dehydrogenases / Q000037:antagonists & inhibitors; D001487:Basidiomycota / Q000737:chemistry*; D018360:Crystallography, X-Ray; D004791:Enzyme Inhibitors / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D008958:Models, Molecular; D015394:Molecular Structure; D012717:Sesquiterpenes / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology
chemical_list: D004791:Enzyme Inhibitors; D012717:Sesquiterpenes; C582904:conosilane A; D042842:11-beta-Hydroxysteroid Dehydrogenases