title: Antimicrobial rubrolides from a South African species of Synoicum tunicate.
abstract: The CH₂Cl₂-MeOH extract of a South African tunicate described as the new Synoicum globosum Parker-Nance sp. nov. (Ascidiacea, Aplousobranchia) was subjected to ¹H NMR-guided fractionation. This resulted in the identification of new 3″-bromorubrolide F (1), 3'-bromorubrolide E (2), 3'-bromorubrolide F (3), and 3',3″-dibromorubrolide E (4) and reisolation of known rubrolides E (5) and F (6), based on NMR spectroscopic and mass spectrometric data. Biological testing of both new and known members of this reported antimicrobial family of halogenated, aryl-substituted furanones indicated moderate antibacterial properties for 3'-bromorubrolide E (2), 3',3″-dibromorubrolide E (4), and rubrolide F (6) against methicillin-resistant Staphylococcus aureus (MRSA) and S. epidermidis.
authors.affiliation: Department of Pharmaceutical Sciences, College of Pharmacy, 203 Pharmacy Building, Oregon State University, Corvallis, Oregon 97331, USA.
authors.forename: Justyna
authors.initials: J
authors.lastname: Sikorska
authors.forename: Shirley
authors.initials: S
authors.lastname: Parker-Nance
authors.forename: Michael T
authors.initials: MT
authors.lastname: Davies-Coleman
authors.forename: Oliver B
authors.initials: OB
authors.lastname: Vining
authors.forename: Aleksandra E
authors.initials: AE
authors.lastname: Sikora
authors.forename: Kerry L
authors.initials: KL
authors.lastname: McPhail
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D005663:Furans / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D016106:Methicillin Resistance / Q000187:drug effects; D055624:Methicillin-Resistant Staphylococcus aureus / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D009792:Oceans and Seas; D013019:South Africa; D013212:Staphylococcus epidermidis / Q000187:drug effects; D014561:Urochordata / Q000737:chemistry*
chemical_list: C577724:3''-bromorubrolide F; D000900:Anti-Bacterial Agents; D005663:Furans