title: Experience with the combination of dutasteride and tamsulosin in the long-term management of benign prostatic hyperplasia.
abstract: Lower urinary tract symptoms (LUTS) caused by benign prostatic hyperplasia (BPH) commonly affect older men. These bothersome symptoms can lead to a decreased quality of life. Currently, two classes of drugs - α-adrenergic blockers and 5α-reductase inhibitors - are prescribed to treat LUTS secondary to BPH. Due to their different mechanisms of action, these medications work in a synergistic manner. Trials of combination therapy have been conducted to assess its effect compared with monotherapy. Current data support combination therapy in men with moderately enlarged prostates and moderate to severe symptoms.
authors.affiliation: James Buchanan Brady Department of Urology, Weill Cornell Medical College of Cornell University, New York, USA.
authors.forename: Bilal
authors.initials: B
authors.lastname: Chughtai
authors.forename: Dean S
authors.initials: DS
authors.lastname: Elterman
authors.forename: Richard
authors.initials: R
authors.lastname: Lee
authors.forename: Alexis E
authors.initials: AE
authors.lastname: Te
authors.forename: Steven A
authors.initials: SA
authors.lastname: Kaplan