title: Inhibitory effects of resveratrol analogs on mushroom tyrosinase activity.
abstract: Skin pigmentation disorders typically involve an overproduction or uneven distribution of melanin, which results in skin spots. Resveratrol can inhibit tyrosinase, the active enzyme in the synthesis of melanin, but it does not inhibit the synthesis of melanin to an extent that enables its use alone as a skin whitening agent in pharmaceutical formulations, so its use as a coadjuvant in treatment of hyperpigmentation is suggested. Six resveratrol analogs were tested for tyrosinase inhibitory activity in vitro. Among the analogs tested, compound D was the most powerful tyrosinase inhibitor (IC(50) = 28.66 µg/mL), two times more active than resveratrol (IC(50) = 57.05 µg/mL), followed by the analogs A, E, B, F and C, respectively. This demonstrated that the hydroxylation at C4' on the phenolic ring was the molecular modification with most importance for the observed activity.
authors.affiliation: NIQUA, Federal University of Juiz de Fora, Juiz de Fora, Minas Gerais 36036-900, Brazil. dannyzimmermann@yahoo.com.br
authors.forename: Danielle Cristina Zimmermann
authors.initials: DC
authors.lastname: Franco
authors.forename: Gustavo Senra Gonçalves
authors.initials: GS
authors.lastname: de Carvalho
authors.forename: Paula Rafaela
authors.initials: PR
authors.lastname: Rocha
authors.forename: Raquel
authors.initials: R
authors.lastname: da Silva Teixeira
authors.forename: Adilson David
authors.initials: AD
authors.lastname: da Silva
authors.forename: Nádia Rezende Barbosa
authors.initials: NR
authors.lastname: Raposo
mesh_terms: D000363:Agaricales / Q000201:enzymology*; D004789:Enzyme Activation / Q000187:drug effects; D004791:Enzyme Inhibitors / Q000737:chemistry / Q000494:pharmacology*; D014442:Monophenol Monooxygenase / Q000037:antagonists & inhibitors* / Q000378:metabolism; D000077185:Resveratrol; D013267:Stilbenes / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D004791:Enzyme Inhibitors; D013267:Stilbenes; D014442:Monophenol Monooxygenase; D000077185:Resveratrol