title: [Membrane-modifying effect of taurine].
abstract: The effect of taurine on the membrane-bound processes in rat erythrocytes and peritoneal mast cells was studied. By EPR method using spin probe 5-DS a significant decrease in the order parameter S of erythrocyte membrane phospholipid acyl chains in in vitro experiments after incubation with taurine (10 mM, 1 h) was shown. The increase of erythrocyte membrane response to peroxide hemolysis was also observed, that was apparently induced by decrease of membrane viscosity as a result of lessening the solidity of the erythrocyte membrane phospholipid packing. The different effects of taurine on ionophore A23187 and compound 48/80-stimulated functional activity of the peritoneal rat mast cells by various modes of administration (peroral, intraperitoneal, intramuscular) were shown. This makes it possible to conclude that the mechanism of taurine activity at the organism level seems to be a mediated process and systemic by nature.
authors.forename: M Ia
authors.initials: MIa
authors.lastname: Akhalaia
authors.forename: E A
authors.initials: EA
authors.lastname: Kushnareva
authors.forename: E Iu
authors.initials: EIu
authors.lastname: Parshina
authors.forename: A G
authors.initials: AG
authors.lastname: Platonov
authors.forename: E E
authors.initials: EE
authors.lastname: Graevskaia
mesh_terms: D000818:Animals; D000001:Calcimycin / Q000494:pharmacology; D004578:Electron Spin Resonance Spectroscopy; D004910:Erythrocyte Membrane / Q000737:chemistry / Q000187:drug effects*; D004912:Erythrocytes / Q000187:drug effects*; D006461:Hemolysis; D006632:Histamine / Q000032:analysis; D007476:Ionophores / Q000494:pharmacology; D008407:Mast Cells / Q000187:drug effects*; D010537:Peritoneum / Q000166:cytology; D010743:Phospholipids / Q000737:chemistry; D051381:Rats; D013654:Taurine / Q000494:pharmacology*; D003189:p-Methoxy-N-methylphenethylamine / Q000494:pharmacology
chemical_list: D007476:Ionophores; D010743:Phospholipids; D013654:Taurine; D000001:Calcimycin; D003189:p-Methoxy-N-methylphenethylamine; D006632:Histamine