title: Isolation, characterization and cytotoxic activity of benzophenone glucopyranosides from Mahkota Dewa (Phaleria macrocarpa (Scheff.) Boerl).
abstract: Two benzophenone glucopyranosides have been isolated from the nut shell part of Mahkota Dewa. The structures were identified as 2,4',6-trihydroxy-4-methoxy-benzophenone-2-O-β-d-glucoside (Mahkoside A) and 2,4',6-trihydroxy-4-methoxy-6″-acetyl-benzophenone-2-O-β-d-glucoside (Mahkoside B). Mahkoside B was recognized as a novel compound. Furthermore, a series of benzophenone glucopyranoside derivatives (compounds 3-18) were synthesized and their bioactivities were characterized. Our results demonstrated that compound 18 has significant cytotoxicity against two esophageal cancer cell lines, stomach cancer cell line and prostate cancer cell line, with IC(50) less than 10 μM, indicating its potential activity against cancer cells.
authors.affiliation: School of Pharmaceutical Science, Zhengzhou University, Zhengzhou, Henan, China.
authors.forename: Sai-Yang
authors.initials: SY
authors.lastname: Zhang
authors.forename: Quan-Hai
authors.initials: QH
authors.lastname: Zhang
authors.forename: Wen
authors.initials: W
authors.lastname: Zhao
authors.forename: Xiao
authors.initials: X
authors.lastname: Zhang
authors.forename: Qi
authors.initials: Q
authors.lastname: Zhang
authors.forename: Yue-Feng
authors.initials: YF
authors.lastname: Bi
authors.forename: Yan-Bing
authors.initials: YB
authors.lastname: Zhang
mesh_terms: D001577:Benzophenones / Q000737:chemistry* / Q000302:isolation & purification / Q000633:toxicity; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D004354:Drug Screening Assays, Antitumor; D005960:Glucosides / Q000138:chemical synthesis / Q000737:chemistry* / Q000302:isolation & purification / Q000633:toxicity; D006027:Glycosides / Q000737:chemistry* / Q000302:isolation & purification / Q000633:toxicity; D006801:Humans; D009754:Nuts / Q000737:chemistry; D010636:Phenols / Q000737:chemistry* / Q000302:isolation & purification / Q000633:toxicity; D017382:Reactive Oxygen Species / Q000378:metabolism; D029645:Thymelaeaceae / Q000737:chemistry*
chemical_list: C578846:2,4',6-trihydroxy-4-methoxy-6'-acetylbenzophenone-2-O-glucoside; D001577:Benzophenones; D005960:Glucosides; D006027:Glycosides; D010636:Phenols; D017382:Reactive Oxygen Species; C511964:mahkoside A; C047723:benzophenone