title: Nutritional and hormonal modulation of adiponectin and its receptors adipoR1 and adipoR2.
abstract: Adiponectin is the most abundant plasma protein synthesized mostly by adipose tissue and is an insulin-sensitive hormone, playing a central role in glucose and lipid metabolism. Adiponectin effects are mediated via two receptors, adipoR1 and adipoR2. Several hormones and diet components that are involved in insulin resistance may impair insulin sensitivity at least in part by decreasing adiponectin and adiponectin receptors. Adiponectin expression and serum levels are associated with the amount and type of fatty acids and carbohydrate consumed. Other food items, such as vitamins, alcohol, sodium, green tea, and coffee, have been reported to modify adiponectin levels. Several hormones, including testosterone, estrogen, prolactin, glucocorticoids, catecholamines, and growth hormone, have been shown to inhibit adiponectin production, but the studies are still controversial. Even so, adiponectin is a potential therapeutic target in the treatment of diabetes mellitus and other diseases associated with hypoadiponectinemia.
authors.affiliation: Systemic Inflammation Laboratory, Trauma Research, St. Joseph's Hospital and Medical Center, Phoenix, USA. crioliva@uol.com.br
authors.forename: Cristiane
authors.initials: C
authors.lastname: de Oliveira
authors.forename: Ana Barbosa Marcondes
authors.initials: AB
authors.lastname: de Mattos
authors.forename: Carolina Biz Rodrigues
authors.initials: CB
authors.lastname: Silva
authors.forename: João Felipe
authors.initials: JF
authors.lastname: Mota
authors.forename: Juliane Costa Silva
authors.initials: JC
authors.lastname: Zemdegs
mesh_terms: D052242:Adiponectin / Q000097:blood / Q000235:genetics / Q000502:physiology*; D000305:Adrenal Cortex Hormones; D004032:Diet; D004040:Dietary Carbohydrates; D004041:Dietary Fats; D005227:Fatty Acids; D015870:Gene Expression; D012739:Gonadal Steroid Hormones; D013006:Growth Hormone; D006728:Hormones / Q000502:physiology*; D006801:Humans; D009747:Nutritional Physiological Phenomena; D011388:Prolactin; D054419:Receptors, Adiponectin / Q000502:physiology*; D013963:Thyroid Hormones; D014815:Vitamins
chemical_list: C475418:ADIPOR1 protein, human; C475420:ADIPOR2 protein, human; D052242:Adiponectin; D000305:Adrenal Cortex Hormones; D004040:Dietary Carbohydrates; D004041:Dietary Fats; D005227:Fatty Acids; D012739:Gonadal Steroid Hormones; D006728:Hormones; D054419:Receptors, Adiponectin; D013963:Thyroid Hormones; D014815:Vitamins; D011388:Prolactin; D013006:Growth Hormone