title: Copper-64 labelling of triazacyclononane-triphosphinate chelators.
abstract: The 1,4,7-triazacyclononane-1,4,7-tris(methylenephosphinic acid) chelators TRAP and NOPO are complexing copper-64 with similar efficiency as 1,4,7-triazacyclononane-triacetic acid (NOTA). The kinetic stability of Cu-64-labelled TRAP-peptides is sufficient for PET imaging at early time points (1-2 h post injection). For labelling of TRAP conjugates, Cu-64 can be recommended as an alternative to Ga-68 to achieve higher resolution of PET images.
authors.affiliation: Pharmazeutische Radiochemie, Technische Universität München, Garching, Germany.
authors.forename: Jakub
authors.initials: J
authors.lastname: Simeček
authors.forename: Hans-Jürgen
authors.initials: HJ
authors.lastname: Wester
authors.forename: Johannes
authors.initials: J
authors.lastname: Notni
mesh_terms: D000818:Animals; D002614:Chelating Agents / Q000737:chemistry; D003301:Copper Radioisotopes; D006571:Heterocyclic Compounds / Q000737:chemistry; D006801:Humans; D007553:Isotope Labeling; D008546:Melanoma, Experimental / Q000175:diagnosis*; D051379:Mice; D008819:Mice, Nude; D015394:Molecular Structure; D010721:Phosphinic Acids / Q000737:chemistry; D049268:Positron-Emission Tomography
chemical_list: C579261:1,4,7-tris(methylenephosphinic acid); D002614:Chelating Agents; D003301:Copper Radioisotopes; D006571:Heterocyclic Compounds; D010721:Phosphinic Acids; C075712:1,4,7-triazacyclononane