title: Protective effects of nizofenone administration on the cognitive impairments induced by chronic restraint stress in mice.
abstract: The present study was aimed to investigate the effects of nizofenone administration on the chronic restraint stress-induced cognitive impairments in mice. Adult male mice were randomized into five groups: control group, nizofenone control group, chronic restraint stress group, and nizofenone treatment groups (3.0mg/kg and 9.0mg/kg). The changes of cognitive performances were examined by Morris water maze (MWM), open field and step-through tests. Our results showed that the cognitive performances in CRS group were markedly deteriorated, accompanied by noticeable alterations in oxidative parameters, acetylcholinesterase activity and catecholamines levels in the hippocampus and the prefrontal cortex. These changes could be reversed by nizofenone treatment. Moreover, CRS group showed higher corticosterone levels and lower catecholamines levels in the serum, which were reversed in the nizofenone treatment groups. Collectively, the present results suggested the potential of nizofenone in attenuating the CRS-induced cognitive impairments.
authors.affiliation: Department of Pharmacology, School of Pharmacy, Xuzhou Medical College, Xuzhou 221004, China. cbpe200901@163.com
authors.forename: Yi
authors.initials: Y
authors.lastname: Liu
authors.forename: Xuemei
authors.initials: X
authors.lastname: Zhuang
authors.forename: Lingshan
authors.initials: L
authors.lastname: Gou
authors.forename: Xin
authors.initials: X
authors.lastname: Ling
authors.forename: Xia
authors.initials: X
authors.lastname: Tian
authors.forename: Ling
authors.initials: L
authors.lastname: Liu
authors.forename: Youguang
authors.initials: Y
authors.lastname: Zheng
authors.forename: Ling
authors.initials: L
authors.lastname: Zhang
authors.forename: Xiaoxing
authors.initials: X
authors.lastname: Yin
mesh_terms: D000110:Acetylcholinesterase / Q000378:metabolism; D000818:Animals; D000975:Antioxidants / Q000378:metabolism; D001362:Avoidance Learning / Q000187:drug effects; D002395:Catecholamines / Q000378:metabolism; D003072:Cognition Disorders / Q000150:complications / Q000188:drug therapy*; D003345:Corticosterone / Q000378:metabolism; D004195:Disease Models, Animal; D005106:Exploratory Behavior / Q000187:drug effects; D006624:Hippocampus / Q000187:drug effects / Q000378:metabolism; D007093:Imidazoles / Q000494:pharmacology* / Q000627:therapeutic use; D008297:Male; D018782:Maze Learning / Q000187:drug effects; D051379:Mice; D008815:Mice, Inbred Strains; D009043:Motor Activity / Q000187:drug effects; D018696:Neuroprotective Agents / Q000494:pharmacology* / Q000627:therapeutic use; D017397:Prefrontal Cortex / Q000187:drug effects / Q000378:metabolism; D012149:Restraint, Physical / Q000379:methods; D013315:Stress, Psychological / Q000097:blood / Q000150:complications / Q000188:drug therapy* / Q000523:psychology
chemical_list: D000975:Antioxidants; D002395:Catecholamines; D007093:Imidazoles; D018696:Neuroprotective Agents; C016910:nizofenone; D000110:Acetylcholinesterase; D003345:Corticosterone