title: Angioimmunoblastic T-cell lymphoma mice model.
abstract: We established an angioimmunoblastic T-cell lymphoma (AITL) mouse model using NOD/Shi-scid, IL-2Rγ(null) mice as recipients. The immunohistological findings of the AITL mice were almost identical to those of patients with AITL. In addition, substantial amounts of human immunoglobulin G/A/M were detected in the sera of the AITL mice. This result indicates that AITL tumor cells helped antibody production by B cells or plasma cells. This is the first report of reconstituting follicular helper T (TFH) function in AITL cells in an experimental model, and this is consistent with the theory that TFH cell is the cell of origin of AITL tumor cells.
authors.affiliation: Department of Medical Oncology and Immunology, Nagoya City University Graduate School of Medical Sciences, 1 Kawasumi, Mizuho-chou, Mizuho-ku, Nagoya, Aichi 467-8601, Japan.
authors.forename: Fumihiko
authors.initials: F
authors.lastname: Sato
authors.forename: Takashi
authors.initials: T
authors.lastname: Ishida
authors.forename: Asahi
authors.initials: A
authors.lastname: Ito
authors.forename: Fumiko
authors.initials: F
authors.lastname: Mori
authors.forename: Ayako
authors.initials: A
authors.lastname: Masaki
authors.forename: Hisashi
authors.initials: H
authors.lastname: Takino
authors.forename: Tomoko
authors.initials: T
authors.lastname: Narita
authors.forename: Masaki
authors.initials: M
authors.lastname: Ri
authors.forename: Shigeru
authors.initials: S
authors.lastname: Kusumoto
authors.forename: Susumu
authors.initials: S
authors.lastname: Suzuki
authors.forename: Hirokazu
authors.initials: H
authors.lastname: Komatsu
authors.forename: Akio
authors.initials: A
authors.lastname: Niimi
authors.forename: Ryuzo
authors.initials: R
authors.lastname: Ueda
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Inagaki
authors.forename: Shinsuke
authors.initials: S
authors.lastname: Iida
mesh_terms: D000818:Animals; D004268:DNA-Binding Proteins / Q000032:analysis; D004195:Disease Models, Animal; D006801:Humans; D007119:Immunoblastic Lymphadenopathy / Q000276:immunology / Q000473:pathology*; D017493:Leukocyte Common Antigens / Q000032:analysis; D008198:Lymph Nodes / Q000473:pathology; D016411:Lymphoma, T-Cell, Peripheral / Q000276:immunology / Q000473:pathology*; D051379:Mice; D016688:Mice, Inbred NOD; D009368:Neoplasm Transplantation; D051560:Proto-Oncogene Proteins c-bcl-6; D014183:Transplantation, Heterologous
chemical_list: C084103:BCL6 protein, human; D004268:DNA-Binding Proteins; D051560:Proto-Oncogene Proteins c-bcl-6; D017493:Leukocyte Common Antigens