title: Crossed cerebellar diaschisis: insights into oxygen challenge MRI.
abstract: Hyperoxia during T2*-weighted magnetic resonance imaging (oxygen challenge imaging (OCI)) causes T2*-weighted signal change that is dependent on cerebral blood volume (CBV) and oxygen extraction fraction (OEF). Crossed cerebellar diaschisis (CCD), where CBV is reduced but OEF is maintained, may be used to understand the relative contributions of OEF and CBV to OCI results. In subjects with large hemispheric strokes, OCI showed reduced signal change in the contralesional cerebellum (P=0.027, n=12). This was associated with reduced CBV in contralesional cerebellum (P=0.039, n=9). CCD may be a useful model to determine the relative contribution of CBV to signal change measured by OCI.
authors.affiliation: Institute of Neurosciences and Psychology, School of Medicine, University of Glasgow, Glasgow, UK.
authors.forename: Krishna A
authors.initials: KA
authors.lastname: Dani
authors.forename: Celestine
authors.initials: C
authors.lastname: Santosh
authors.forename: David
authors.initials: D
authors.lastname: Brennan
authors.forename: Donald M
authors.initials: DM
authors.lastname: Hadley
authors.forename: Keith W
authors.initials: KW
authors.lastname: Muir
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001810:Blood Volume; D002531:Cerebellum / Q000098:blood supply / Q000000981:diagnostic imaging / Q000378:metabolism / Q000503:physiopathology; D002560:Cerebrovascular Circulation; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D008955:Models, Cardiovascular; D010100:Oxygen / Q000378:metabolism*; D011859:Radiography; D012189:Retrospective Studies; D020521:Stroke / Q000378:metabolism / Q000503:physiopathology
chemical_list: D010100:Oxygen