title: Highly enantioselective [4 + 2] cyclization of chloroaldehydes and 1-azadienes catalyzed by N-heterocyclic carbenes.
abstract: Highly functionalized dihydropyridinones were synthesized via the N-heterocyclic carbene-catalyzed enantioselective [4 + 2] annulation of α-chloroaldehydes and azadienes. Hydrogenation of the resulted dihydropyridinones afforded the corresponding piperidinones with high enantiopurity.
authors.affiliation: Beijing National Laboratory for Molecular Sciences, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China.
authors.forename: Teng-Yue
authors.initials: TY
authors.lastname: Jian
authors.forename: Li-Hui
authors.initials: LH
authors.lastname: Sun
authors.forename: Song
authors.initials: S
authors.lastname: Ye
mesh_terms: D000447:Aldehydes / Q000737:chemistry*; D001372:Aza Compounds / Q000737:chemistry*; D003500:Cyclization; D006865:Hydrogenation; D008697:Methane / Q000031:analogs & derivatives* / Q000737:chemistry; D015394:Molecular Structure; D011728:Pyridones / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D000447:Aldehydes; D001372:Aza Compounds; D011728:Pyridones; C030011:carbene; D008697:Methane