title: [Hepatoprotective and immunomodulatory effects of infliximab on experimental alcoholic steatohepatitis].
abstract: The effect of infliximab (1 and 10 mg/kg, i.p., during 10 days) on alcoholic steatohepatitis has been studied in rats fed with ethanol-containing liquid diet over 10 weeks. Both doses of infliximab showed immunomodulatory and anti-inflammatory effects, whereas only the maximum drug dose significantly decreased lipid accumulation in the liver. It can be concluded that infliximab (10 mg/kg) acts as an effective hepatoprotector, anti-inflammatory agent, and immunomodulator in rats with experimental alcoholic steatohepatitis.
authors.forename: P Ch
authors.initials: PCh
authors.lastname: Kirvel'
authors.forename: M V
authors.initials: MV
authors.lastname: Goretskaia
authors.forename: O Ia
authors.initials: OIa
authors.lastname: Lukivskaia
authors.forename: E E
authors.initials: EE
authors.lastname: Naruta
authors.forename: E B
authors.initials: EB
authors.lastname: Belokonskaia
authors.forename: V U
authors.initials: VU
authors.lastname: Buko
mesh_terms: D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology*; D000911:Antibodies, Monoclonal / Q000494:pharmacology*; D002492:Central Nervous System Depressants / Q000009:adverse effects / Q000494:pharmacology; D004195:Disease Models, Animal; D000431:Ethanol / Q000009:adverse effects / Q000494:pharmacology; D005235:Fatty Liver, Alcoholic / Q000097:blood / Q000188:drug therapy* / Q000209:etiology; D005260:Female; D007155:Immunologic Factors / Q000494:pharmacology*; D000069285:Infliximab; D015227:Lipid Peroxidation / Q000187:drug effects*; D051381:Rats; D017208:Rats, Wistar
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D000911:Antibodies, Monoclonal; D002492:Central Nervous System Depressants; D007155:Immunologic Factors; D000431:Ethanol; D000069285:Infliximab