title: The new nucleoporin: regulator of transcriptional repression and beyond.
abstract: Transcriptional regulation is a complex process that requires the integrated action of many multi-protein complexes. The way in which a living cell coordinates the action of these complexes in time and space is still poorly understood. Recent work has shown that nuclear pores, well known for their role in 3' processing and export of transcripts, also participate in the control of transcriptional initiation. We have recently begun to explore how nuclear pores interface with the well-described machinery that regulates initiation. This work led to the discovery that specific nucleoporins are required for binding of the repressor protein Mig1 to its site in target promoters. Nuclear pores are therefore involved in repressing, as well as activating, transcription. Here we discuss in detail the main models explaining our result and consider what each implies about the roles that nuclear pores play in the regulation of gene expression.
authors.affiliation: Department of Surgery, Washington University School of Medicine, St. Louis, MO, USA.
authors.forename: Nayan J
authors.initials: NJ
authors.lastname: Sarma
authors.forename: Kristine
authors.initials: K
authors.lastname: Willis
mesh_terms: D015966:Gene Expression Regulation, Fungal; D006657:Histones / Q000378:metabolism; D018398:Homeodomain Proteins / Q000378:metabolism; D006801:Humans; D008958:Models, Molecular; D022022:Nuclear Pore / Q000378:metabolism; D028861:Nuclear Pore Complex Proteins / Q000235:genetics / Q000378:metabolism*; D011401:Promoter Regions, Genetic; D012097:Repressor Proteins / Q000235:genetics / Q000378:metabolism; D012441:Saccharomyces cerevisiae / Q000235:genetics / Q000378:metabolism; D029701:Saccharomyces cerevisiae Proteins / Q000235:genetics / Q000378:metabolism*; D043324:beta-Fructofuranosidase / Q000235:genetics / Q000378:metabolism
chemical_list: D006657:Histones; D018398:Homeodomain Proteins; C085976:MIG1 protein, S cerevisiae; C097740:NUP120 protein, S cerevisiae; C091271:NUP133 protein, S cerevisiae; D028861:Nuclear Pore Complex Proteins; D012097:Repressor Proteins; D029701:Saccharomyces cerevisiae Proteins; C097899:homeobox protein HOXA9; C093350:nuclear pore complex protein 98; C468437:SUC2 protein, S cerevisiae; D043324:beta-Fructofuranosidase