title: The expression patterns of Msi1 related with the glioma grade and the cytoplasmic Msi1 promotes angiogenesis.
abstract: To investigate the expression patterns of Msi1 and its relationship with tumour grading and angiogenesis in human glioma. Msi1 expression and the angiogenesis labelled by CD31 were detected by immunohistochemical staining in glioma from Grade I to Grade IV. MVD-CD31 was counted respectively in nuclear and cytoplasmic positive areas of Msi1. There was weak expression of Msi1 in the adjacent normal brain tissue of glioma, and there were less MVD-CD31 than in glioma. Glioma showed strong expression and different patterns of Msi1. From Grade I to Grade IV glioma, the expression pattern of Msi1 was changed from nuclear into cytoplasmic pattern gradually (P<0.05), and the expression patterns of Msi1 were related with the angiogenesis of glioma (P<0.05). It suggested that cytoplasmic Msi1 promoted angiogenesis and nuclear Msi-1 inhibited angiogenesis in glioma (P<0.05). Msi1 has different expression patterns in glioma from Grade I to Grade IV, and the different expression patterns play diverse roles in angiogenesis of glioma. This might explain that from Grade I to IV, glioma showed worse and worse prognosis.
authors.affiliation: Experimental Medicine Research Center, Binzhou Medical University, 346 Guanhai Road, Yantai, Shandong 264003, China.
authors.forename: Xiaodong
authors.initials: X
authors.lastname: Song
authors.forename: Chengjun
authors.initials: C
authors.lastname: Zhou
authors.forename: Shuai
authors.initials: S
authors.lastname: Zhou
authors.forename: Luping
authors.initials: L
authors.lastname: Zhang
authors.forename: Guoying
authors.initials: G
authors.lastname: Feng
authors.forename: Dongmei
authors.initials: D
authors.lastname: Zhao
authors.forename: Fei
authors.initials: F
authors.lastname: Huang
mesh_terms: D000368:Aged; D001932:Brain Neoplasms / Q000235:genetics* / Q000473:pathology; D003593:Cytoplasm / Q000235:genetics; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D005910:Glioma / Q000235:genetics* / Q000473:pathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D009389:Neovascularization, Pathologic / Q000235:genetics*; D009419:Nerve Tissue Proteins / Q000096:biosynthesis / Q000235:genetics*; D011379:Prognosis; D016601:RNA-Binding Proteins / Q000096:biosynthesis / Q000235:genetics*
chemical_list: C491297:MSI1 protein, human; D009419:Nerve Tissue Proteins; D016601:RNA-Binding Proteins