title: Molecular targets related to inflammation and insulin resistance and potential interventions.
abstract: Inflammation and insulin resistance are common in several chronic diseases, such as obesity, type 2 diabetes mellitus, metabolic syndrome, cancer, and cardiovascular diseases. Various studies show a relationship between these two factors, although the mechanisms involved are not completely understood yet. Here, we discuss the molecular basis of insulin resistance and inflammation and the molecular aspects on inflammatory pathways interfering in insulin action. Moreover, we explore interventions based on molecular targets for preventing or treating correlated disorders, advances for a better characterization, and understanding of the mechanisms and mediators involved in the different inflammatory and insulin resistance conditions. Finally, we address biotechnological studies for the development of new potential therapies and interventions.
authors.affiliation: Institute of Physical Activity Sciences and Sports, Cruzeiro do Sul University, 01506-000 São Paulo, SP, Brazil. sandromh@yahoo.com.br
authors.forename: Sandro M
authors.initials: SM
authors.lastname: Hirabara
authors.forename: Renata
authors.initials: R
authors.lastname: Gorjão
authors.forename: Marco A
authors.initials: MA
authors.lastname: Vinolo
authors.forename: Alice C
authors.initials: AC
authors.lastname: Rodrigues
authors.forename: Renato T
authors.initials: RT
authors.lastname: Nachbar
authors.forename: Rui
authors.initials: R
authors.lastname: Curi
mesh_terms: D000818:Animals; D006801:Humans; D007249:Inflammation / Q000188:drug therapy* / Q000276:immunology*; D007328:Insulin / Q000378:metabolism*; D007333:Insulin Resistance; D058990:Molecular Targeted Therapy / Q000379:methods*
chemical_list: D007328:Insulin