title: Endoscopic management of Ewing's sarcoma of ethmoid sinus within the AMORE framework: a new paradigm.
abstract: The Ablative surgery, MOulage brachytherapy and REconstruction) (AMORE) protocol developed in the Academic Medical Center of Amsterdam has been used successfully to treat sarcomas. The use of endoscopic surgery fits well within this framework. A 6-year-old boy presented with Ewing Sarcoma of left ethmoid sinus closest to orbit. The patient underwent neoadjuvant chemotherapy followed by complete endoscopic resection, brachytherapy and reconstruction. Brachytherapy was administered by iridium catheters through limited Lynch-Howarth incision. Skull base defect was reconstructed with a galea flap. The use of endoscopic surgery complemented by neoadjuvant chemotherapy and brachytherapy might maximize tumor control while reducing morbidity.
authors.affiliation: Academic Clinic of Otolaryngology and Head-Neck Surgery, Department of Surgical Sciences, University of Florence, Florence, Italy.
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Meccariello
authors.forename: Johannes H M
authors.initials: JH
authors.lastname: Merks
authors.forename: Bradley R
authors.initials: BR
authors.lastname: Pieters
authors.forename: Wouter R
authors.initials: WR
authors.lastname: van Furth
authors.forename: Peerooz
authors.initials: P
authors.lastname: Saeed
authors.forename: Reineke A
authors.initials: RA
authors.lastname: Schoot
authors.forename: Nicole J M
authors.initials: NJ
authors.lastname: Freling
authors.forename: Johannes
authors.initials: J
authors.lastname: Bras
authors.forename: Simon D
authors.initials: SD
authors.lastname: Strackee
authors.forename: Alfons J M
authors.initials: AJ
authors.lastname: Balm
authors.forename: Christos
authors.initials: C
authors.lastname: Georgalas
mesh_terms: D001859:Bone Neoplasms / Q000175:diagnosis / Q000628:therapy*; D001918:Brachytherapy / Q000379:methods; D059248:Chemoradiotherapy / Q000379:methods; D002648:Child; D003131:Combined Modality Therapy; D004724:Endoscopy / Q000379:methods*; D005005:Ethmoid Sinus; D005500:Follow-Up Studies; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D020360:Neoadjuvant Therapy / Q000379:methods*; D019651:Plastic Surgery Procedures / Q000379:methods*; D012512:Sarcoma, Ewing / Q000175:diagnosis / Q000628:therapy*; D016896:Treatment Outcome