title: Medicinal significance of benzothiazole scaffold: an insight view.
abstract: Heterocycles bearing nitrogen, sulphur and thiazole moieties constitute the core structure of a number of biologically interesting compounds. Benzothiazole, a group of xenobiotic compounds containing a benzene ring fused with a thiazole ring, are used worldwide for a variety of therapeutic applications. Benzothiazole and their heterocyclic derivatives represent an important class of compounds possessing a wide spectrum of biological activities. The myriad spectrum of medicinal properties associated with benzothiazole related drugs has encouraged the medicinal chemists to synthesize a large number of novel therapeutic agents. Several analogues containing benzothiazole ring system exhibit significant antitumour, antimicrobial, antidiabetic, anti-inflammatory, anticonvulsant, antiviral, antioxidant, antitubercular, antimalarial, antiasthmatic, anthelmintic, photosensitizing, diuretic, analgesic and other activities. This article is an attempt to present the research work reported in recent scientific literature on different pharmacological activities of benzothiazole compounds.
authors.affiliation: Institute of Pharmaceutical Sciences, Kurukshetra University, Kurukshetra, India. sharma_prabodh@rediffmail.com
authors.forename: Prabodh Chander
authors.initials: PC
authors.lastname: Sharma
authors.forename: Alka
authors.initials: A
authors.lastname: Sinhmar
authors.forename: Archana
authors.initials: A
authors.lastname: Sharma
authors.forename: Harish
authors.initials: H
authors.lastname: Rajak
authors.forename: Dharam Pal
authors.initials: DP
authors.lastname: Pathak
mesh_terms: D000890:Anti-Infective Agents / Q000737:chemistry / Q000494:pharmacology*; D000962:Antimalarials / Q000737:chemistry / Q000494:pharmacology*; D000970:Antineoplastic Agents / Q000737:chemistry / Q000494:pharmacology*; D000995:Antitubercular Agents / Q000737:chemistry / Q000494:pharmacology*; D052160:Benzothiazoles / Q000737:chemistry / Q000494:pharmacology*; D004791:Enzyme Inhibitors / Q000737:chemistry / Q000494:pharmacology*; D006801:Humans; D015394:Molecular Structure
chemical_list: D000890:Anti-Infective Agents; D000962:Antimalarials; D000970:Antineoplastic Agents; D000995:Antitubercular Agents; D052160:Benzothiazoles; D004791:Enzyme Inhibitors; C005465:benzothiazole