title: A new saponin from tea seed pomace (Camellia oleifera Abel) and its protective effect on PC12 cells.
abstract: A new triterpenoid saponin, oleiferasaponin A₁, was isolated from tea seed pomace (Camellia oleifera Abel). The structure of oleiferasaponin A₁ was elucidated on the basis of chemical and physicochemical evidence and was found to be 22-O-cis-2-hexenoyl-A₁-barrigenol 3-O-[β-D-galactopyranosyl(1→2)] [β-D-glucopyranosyl(1→2)-α-L-arabinopyranosyl(1→3)]-β-D-glucopyranosiduronic acid. PC12 cells injured with H₂O₂ were used as the model to test the protective effects of oleiferasaponin A₁. The results indicated that oleiferasaponin A₁ can potentially prevent the H₂O₂-induced cell death of PC12 cells.
authors.affiliation: Key Laboratory of Tea Biochemistry & Biotechnology, Ministry of Education and Ministry of Agriculture, Anhui Agricultural University, Hefei 230036, China.
authors.forename: Xin-Fu
authors.initials: XF
authors.lastname: Zhang
authors.forename: Ying-Ying
authors.initials: YY
authors.lastname: Han
authors.forename: Guan-Hu
authors.initials: GH
authors.lastname: Bao
authors.forename: Tie-Jun
authors.initials: TJ
authors.lastname: Ling
authors.forename: Liang
authors.initials: L
authors.lastname: Zhang
authors.forename: Li-Ping
authors.initials: LP
authors.lastname: Gao
authors.forename: Tao
authors.initials: T
authors.lastname: Xia
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000737:chemistry / Q000494:pharmacology; D028244:Camellia / Q000737:chemistry*; D002470:Cell Survival / Q000187:drug effects; D006861:Hydrogen Peroxide / Q000633:toxicity; D016716:PC12 Cells; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology; D020011:Protective Agents / Q000737:chemistry* / Q000494:pharmacology*; D051381:Rats; D012503:Saponins / Q000737:chemistry* / Q000494:pharmacology*
chemical_list: D000975:Antioxidants; D010936:Plant Extracts; D020011:Protective Agents; D012503:Saponins; D006861:Hydrogen Peroxide