title: Profilin phosphorylation as a VEGFR effector in angiogenesis.
abstract: Vascular endothelial growth factor (VEGF) signalling induces embryonic vascular development and angiogenesis in adult tissues. Direct phosphorylation of the actin-binding protein profilin by VEGF receptors is now shown to increase its affinity for actin, and to be essential for adult but not embryonic arteriogenesis.
authors.forename: Michael
authors.initials: M
authors.lastname: Simons
authors.forename: Martin A
authors.initials: MA
authors.lastname: Schwartz
mesh_terms: D000199:Actins / Q000502:physiology; D000818:Animals; D051379:Mice; D009024:Morphogenesis / Q000502:physiology; D018919:Neovascularization, Physiologic; D010766:Phosphorylation; D051304:Profilins / Q000378:metabolism*; D040262:Receptors, Vascular Endothelial Growth Factor / Q000502:physiology*; D015398:Signal Transduction / Q000502:physiology
chemical_list: D000199:Actins; D051304:Profilins; D040262:Receptors, Vascular Endothelial Growth Factor