title: Current concepts in cell toxicity.
abstract: This overview provides a basic definition of cellular death and the mechanisms that are associated with cell death: apoptosis and necrosis. It includes a description of structural changes and macromolecular degradation and the roles of signaling, mitochondria, and genetic changes in the two forms of cell death.
authors.affiliation: Karolinska Institutet, Stockholm, Sweden.
authors.forename: A
authors.initials: A
authors.lastname: Samali
authors.forename: B
authors.initials: B
authors.lastname: Zhivotovsky
authors.forename: S
authors.initials: S
authors.lastname: Orrenius
mesh_terms: D000818:Animals; D017209:Apoptosis / Q000187:drug effects; D016923:Cell Death / Q000187:drug effects*; D004249:DNA Damage / Q000187:drug effects; D006801:Humans; D063306:Mitophagy / Q000187:drug effects; D009336:Necrosis / Q000139:chemically induced / Q000378:metabolism; D059748:Proteolysis / Q000187:drug effects; D020871:RNA Stability / Q000187:drug effects; D015398:Signal Transduction / Q000187:drug effects; D014116:Toxicology / Q000639:trends*