title: Comparing serum levels of cardiac biomarkers in cancer patients receiving chemotherapy and subjects with chronic periodontitis.
abstract: BACKGROUND
  Chronic periodontitis (CP) is a chronic inflammation associated with elevations of several inflammatory and cardiac markers. Studies implicated CP as one of the etiologies in coronary heart disease (CHD). Cardiotoxicity is a major complication of anticancer drugs, including anthracyclines and 5-fluorouracil (5FU). The most severe cardiac complications are heart failure, arrhythmia and coronary heart disease (CHD). In this study, we compared the level of inflammatory factors and cardiac markers between chronic periodontitis patients and cancer patients receiving chemotherapy.
  
  
  METHODS
  108 blood samples of periodontally healthy subjects were obtained on random from Hong Kong Red Cross, and these represented the controlled population. Forty-four patients diagnosed with chronic periodontitis were recruited from the West China Hospital of Stomatology, Sichuan University. They have received scaling and root planning with mean pocket depths of 6.05 mm. Thirty breast cancer patients diagnosed with invasive ductal carcinoma from UNIMED Medical Institute, Hong Kong gave consent to participate in this study. They received 4 cycles of 500mg/m2 5-fluorouracil, 75 mg/m2 epirubicin and 500mg/m2 cyclophosphamide at a 3-week interval between each cycle. Peripheral venous blood from each group was taken for measurement of blood cells, inflammatory marker (P-selectin, high sensitvity C-reactive protein) and cardiac markers (troponin T; troponin I; N-terminal pro brain natriuretic peptide (Nt-proBNP) and Lactate dehydrogenase (LDH).
  
  
  RESULTS
  The lymphocyte count was higher (p < 0.05) in periodontitis patients than the other two groups, and more neutrophils (p < 0.05) were seen in cancer patients receiving chemotherapy. The two test groups demonstrated higher levels (p < 0.01) of inflammatory and cardiac markers than the control group.
  
  
  CONCLUSIONS
  The elevated cardiac markers found in periodontitis patients suggested that they may carry potential risks in developing cardiac lesions. Troponin T, troponin I, pro-BNP, LDH and high sensitvity C-reactive protein may be used as markers to monitor cardiac lesions in chronic inflammatory patients.
authors.affiliation: UNIMED Medical Institute, Hong Kong SAR.
authors.forename: WingsT Y
authors.initials: WY
authors.lastname: Loo
authors.forename: Yuan
authors.initials: Y
authors.lastname: Yue
authors.forename: Chang-bin
authors.initials: CB
authors.lastname: Fan
authors.forename: Lan-jun
authors.initials: LJ
authors.lastname: Bai
authors.forename: Yi-ding
authors.initials: YD
authors.lastname: Dou
authors.forename: Min
authors.initials: M
authors.lastname: Wang
authors.forename: Hao
authors.initials: H
authors.lastname: Liang
authors.forename: Mary N B
authors.initials: MN
authors.lastname: Cheung
authors.forename: Louis W C
authors.initials: LW
authors.lastname: Chow
authors.forename: Jin-le
authors.initials: JL
authors.lastname: Li
authors.forename: Ye
authors.initials: Y
authors.lastname: Tian
authors.forename: Liu
authors.initials: L
authors.lastname: Qing
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D015415:Biomarkers / Q000097:blood*; D001943:Breast Neoplasms / Q000097:blood* / Q000188:drug therapy*; D016022:Case-Control Studies; D055113:Chronic Periodontitis / Q000097:blood*; D005260:Female; D006801:Humans; D018836:Inflammation Mediators / Q000097:blood; D008297:Male; D008875:Middle Aged; D009206:Myocardium / Q000378:metabolism*; D055815:Young Adult
chemical_list: D015415:Biomarkers; D018836:Inflammation Mediators