title: Leishmanicidal activity of two naphthoquinones against Leishmania donovani.
abstract: Here we studied ability of two naphthoquinones to inhibit Leishmania growth (2,3-dichloro-5,8-dihydroxy-1,4-naphthoquinone (TR 001) and 2,3-dibromo-1,4-naphthoquinone (TR 002). TR 001 was more efficient than TR 002 in inducing killing of promastigotes and intracellular amastigotes. These values compare well to those obtained with the standard first-line antileishmanial agent sodium stibogluconate (SSG). TR 001 also induced significantly more nitric oxide (NO) production than TR 002 or SSG. Taken together, these data show that TR 001 and TR 002 could be promising new drugs for treatment of visceral leishmaniasis.
authors.affiliation: Department of Pathology, The Wexner Medical Centre, The Ohio State University, OH 43210, USA. lezama-davila.1@osu.edu
authors.forename: Claudio Manuel
authors.initials: CM
authors.lastname: Lezama-Dávila
authors.forename: Angelica Patricia
authors.initials: AP
authors.lastname: Isaac-Márquez
authors.forename: Govind
authors.initials: G
authors.lastname: Kapadia
authors.forename: Katherine
authors.initials: K
authors.lastname: Owens
authors.forename: Steve
authors.initials: S
authors.lastname: Oghumu
authors.forename: Stephen
authors.initials: S
authors.lastname: Beverley
authors.forename: Abhay Rajaninath
authors.initials: AR
authors.lastname: Satoskar
mesh_terms: D000818:Animals; D001854:Bone Marrow Cells / Q000166:cytology; D002478:Cells, Cultured; D007893:Leishmania donovani / Q000187:drug effects*; D008264:Macrophages / Q000187:drug effects / Q000378:metabolism; D051379:Mice; D008810:Mice, Inbred C57BL; D009285:Naphthoquinones / Q000494:pharmacology*; D009569:Nitric Oxide / Q000378:metabolism; D014344:Trypanocidal Agents / Q000494:pharmacology*
chemical_list: C578583:2,3-dibromo-1,4-naphthoquinone; C462781:2,3-dichloro-5,8-dihydroxy-1,4-naphthoquinone; D009285:Naphthoquinones; D014344:Trypanocidal Agents; D009569:Nitric Oxide