title: A seven-coordinated manganese(II) complex with V-shaped ligand bis(N-benzylbenzimidazol-2-ylmethyl)benzylamine: synthesis, structure, DNA-binding properties and antioxidant activities.
abstract: A manganese(II) complex of the type, [MnL(pic)(2)]·H(2)O, was obtained by the reaction of the V-shaped ligand bis(N-benzylbenzimidazol-2-ylmethyl)benzylamine (L) with Mn(pic)(2) (pic=picrate). The ligand L and Mn(II) complex were confirmed on the basis of elemental analysis, molarconductivities, (1)H NMR, IR, UV-vis spectra and X-ray crystallography. Single-crystal X-ray revealed that central Mn(II) atom is seven-coordinate with a MnN(3)O(4) environment, in which ligand L acts as a tridentate N-donor. The remaining coordination sites were occupied by four O atoms afforded by two picrate anion. Interaction of the free ligand L and Mn(II) complex with DNA were investigated by spectrophotometric methods and viscosity measurements. The results suggested that both ligand L and Mn(II) complex bind to DNA in an intercalative binding mode, and DNA-binding affinity of the Mn(II) complex is stronger than that of ligand L. Moreover, antioxidant assay in vitro shows the Mn(II) complex possesses significant antioxidant activities.
authors.affiliation: School of Chemical and Biological Engineering, Lanzhou Jiaotong University, Lanzhou 730070, PR China. wuhuilu@163.com
authors.forename: Huilu
authors.initials: H
authors.lastname: Wu
authors.forename: Jingkun
authors.initials: J
authors.lastname: Yuan
authors.forename: Ying
authors.initials: Y
authors.lastname: Bai
authors.forename: Hua
authors.initials: H
authors.lastname: Wang
authors.forename: Guolong
authors.initials: G
authors.lastname: Pan
authors.forename: Jin
authors.initials: J
authors.lastname: Kong
mesh_terms: D000818:Animals; D001596:Benzylamines / Q000737:chemistry*; D002417:Cattle; D060326:Chemistry Techniques, Synthetic; D004247:DNA / Q000378:metabolism*; D016166:Free Radical Scavengers / Q000138:chemical synthesis* / Q000737:chemistry / Q000378:metabolism*; D017665:Hydroxyl Radical / Q000737:chemistry; D008024:Ligands; D008345:Manganese / Q000737:chemistry*; D008958:Models, Molecular; D008968:Molecular Conformation; D009942:Organometallic Compounds / Q000138:chemical synthesis* / Q000737:chemistry / Q000378:metabolism*; D013481:Superoxides / Q000737:chemistry; D014783:Viscosity
chemical_list: D001596:Benzylamines; D016166:Free Radical Scavengers; D008024:Ligands; D009942:Organometallic Compounds; D013481:Superoxides; D017665:Hydroxyl Radical; D008345:Manganese; D004247:DNA; C030796:benzylamine