title: Complete genome sequence analysis of a natural reassortant infectious bursal disease virus in China.
abstract: A novel isolate of infectious bursal disease virus (IBDV) was designated GX-NN-L. The GX-NN-L IBDV was a very virulent infectious bursal disease virus (vvIBDV) isolated from broiler flocks in Guangxi province, China, in 2011. The GX-NN-L IBDV caused high mortality, immunosuppression, low weight gain, and bursal atrophy in commercial broilers. Here, we report the complete genome sequence of the GX-NN-L IBDV, a reassortment strain with segments A and B derived from very virulent strains and attenuated IBDV, respectively. These findings from this study provide additional insights into the genetic exchange between attenuated and very virulent strains of IBDV and continuous monitoring of the spread of the virus in chicken.
authors.affiliation: College of Animal Science, South China Agricultural University, Tianhe District, Guangzhou, Guangdong, People's Republic of China.
authors.forename: Feng
authors.initials: F
authors.lastname: Chen
authors.forename: Jiajia
authors.initials: J
authors.lastname: Liu
authors.forename: Zhuanqiang
authors.initials: Z
authors.lastname: Yan
authors.forename: Di
authors.initials: D
authors.lastname: Liu
authors.forename: Jun
authors.initials: J
authors.lastname: Ji
authors.forename: Jianping
authors.initials: J
authors.lastname: Qin
authors.forename: Haiyan
authors.initials: H
authors.lastname: Li
authors.forename: Jingyun
authors.initials: J
authors.lastname: Ma
authors.forename: Yingzuo
authors.initials: Y
authors.lastname: Bi
authors.forename: Qingmei
authors.initials: Q
authors.lastname: Xie
mesh_terms: D000818:Animals; D001284:Atrophy / Q000473:pathology; D018175:Birnaviridae Infections / Q000401:mortality / Q000662:veterinary / Q000821:virology; D001835:Body Weight; D002060:Bursa of Fabricius / Q000473:pathology; D002645:Chickens; D002681:China; D016679:Genome, Viral; D007108:Immune Tolerance; D007243:Infectious bursal disease virus / Q000235:genetics* / Q000302:isolation & purification / Q000472:pathogenicity; D008969:Molecular Sequence Data; D011201:Poultry Diseases / Q000401:mortality / Q000821:virology; D012367:RNA, Viral / Q000235:genetics*; D016865:Reassortant Viruses / Q000235:genetics* / Q000302:isolation & purification / Q000472:pathogenicity; D017422:Sequence Analysis, DNA; D016019:Survival Analysis
chemical_list: D012367:RNA, Viral