title: [The role of lipid-protein interplay in the development of atherogenesis during coronary heart disease and metabolic syndrome].
abstract: Lipid-protein relationships were studied in 155 men and women (mean age 48/9 +/ -0.6 years) with CHD (stable angina of effort) and MS. The frequency of concomitant arterial hypertension in men/women was 100%, aortic atherosclerosis 49.7/24.5%, athersclerosis of lower leg arteries 14.8/0%, chronic obstructive pulmonary disease 27.7/5.2%, locomotor disorders 25.8/14.8%, hepato-biliary diseases 24.5/17.4%, gastro-duodenal disorders 16.8/3.2%, hepatic problems 10.5/26.7%. Heterogeneity of lipid-protein homeostasis was documented. Evaluation of dysproteinemia, besides dyslipidemia, is crucial for estimating activity of inflammation as acute or chronic. Patients with CHD and MS need therapy not only of these conditions but also of concomitant diseases taking into account their phases (exacerbation, remission) and results of dynamic observation. Such approach ensures prevention of progression of combined pathology and improvement of patients' quality of life.
authors.forename: S A
authors.initials: SA
authors.lastname: Matveeva
mesh_terms: D000787:Angina Pectoris / Q000097:blood / Q000453:epidemiology / Q000209:etiology; D050197:Atherosclerosis / Q000097:blood* / Q000453:epidemiology / Q000209:etiology; D001798:Blood Proteins / Q000378:metabolism*; D015897:Comorbidity; D050171:Dyslipidemias / Q000097:blood; D005260:Female; D006801:Humans; D050356:Lipid Metabolism / Q000502:physiology*; D008297:Male; D024821:Metabolic Syndrome / Q000097:blood* / Q000150:complications / Q000453:epidemiology; D008875:Middle Aged; D017202:Myocardial Ischemia / Q000097:blood* / Q000150:complications / Q000453:epidemiology
chemical_list: D001798:Blood Proteins