title: Effectiveness of treatment with surfactant in premature infants with respiratory failure and pulmonary infection.
abstract: BACKGROUND
  Surfactant inactivation is present in neonatal pneumonia.
  
  
  METHODS
  One hundred thirty-nine preterm babies with Birth Weight (BW) < or = 1250 grams were studied and subdivided in two groups: RDS Group, with a diagnosis of "simple" RDS (N 80) and RDS with Pneumonia Group, consisting of babies with a diagnosis of RDS and a positive BALF culture in the first 24-48 h of life (N 59).
  
  
  RESULTS
  Surfactant administration seems less effective in the latter group, because a significantly higher number of infants needed a second dose of surfactant, compared to the patients suffering from RDS alone. (www.actabiomedica.it).
authors.affiliation: Department of Pediatrics, Division of Neonatology, Università Cattolica del Sacro Cuore, Rome, Italy. vento@rm.unicatt.it
authors.forename: Giovanni
authors.initials: G
authors.lastname: Vento
authors.forename: M
authors.initials: M
authors.lastname: Tana
authors.forename: C
authors.initials: C
authors.lastname: Tirone
authors.forename: C
authors.initials: C
authors.lastname: Aurilia
authors.forename: A
authors.initials: A
authors.lastname: Lio
authors.forename: S
authors.initials: S
authors.lastname: Perelli
authors.forename: C
authors.initials: C
authors.lastname: Ricci
authors.forename: C
authors.initials: C
authors.lastname: Romagnoli
mesh_terms: D001992:Bronchoalveolar Lavage Fluid / Q000382:microbiology; D004927:Escherichia coli Infections / Q000188:drug therapy; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature; D015931:Intensive Care, Neonatal / Q000379:methods; D008297:Male; D018410:Pneumonia, Bacterial / Q000188:drug therapy*; D011663:Pulmonary Surfactants / Q000627:therapeutic use*; D012127:Respiratory Distress Syndrome, Newborn / Q000188:drug therapy*; D012131:Respiratory Insufficiency / Q000188:drug therapy*; D012189:Retrospective Studies; D013290:Streptococcal Infections / Q000188:drug therapy; D013292:Streptococcus agalactiae; D016896:Treatment Outcome
chemical_list: D011663:Pulmonary Surfactants