title: JBIR-129 and -139, cytotoxic 34-membered polyol macrolides of microbial origin.
abstract: New 34-membered polyol macrolides JBIR-129 (1) and JBIR-139 (2) were isolated from the culture of the terrestrial Streptomyces RK74. The planar structures of 1 and 2 were established on the basis of 1D and 2D NMR, ESI-TOF-MS, IR, and UV spectra. The relative configurations of the sugar units were determined by analyzing vicinal ¹H-¹H coupling constants and steric information. Both 1 and 2 showed cytotoxic activity against human ovarian adenocarcinoma SKOV-3 cells with IC₅₀ values of 0.3 and 0.4 μM, respectively.
authors.affiliation: Japan Biological Informatics Consortium-JBIC, 2-4-7 Aomi, Koto-ku, Tokyo 135-0064, Japan.
authors.forename: Teppei
authors.initials: T
authors.lastname: Kawahara
authors.forename: Ji-Hwan
authors.initials: JH
authors.lastname: Hwang
authors.forename: Miho
authors.initials: M
authors.lastname: Izumikawa
authors.forename: Junko
authors.initials: J
authors.lastname: Hashimoto
authors.forename: Motoki
authors.initials: M
authors.lastname: Takagi
authors.forename: Kazuo
authors.initials: K
authors.lastname: Shin-ya
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D004354:Drug Screening Assays, Antitumor; D005260:Female; D006801:Humans; D020128:Inhibitory Concentration 50; D007564:Japan; D018942:Macrolides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D013302:Streptomyces / Q000737:chemistry*
chemical_list: D000970:Antineoplastic Agents; C577727:JBIR-129; C577728:JBIR-139; D018942:Macrolides