title: Two sesquiterpene pyridine alkaloids and a triterpenoid saponin from the root barks of Tripterygium hypoglaucum.
abstract: Two new sesquiterpene pyridine alkaloids hypoglaunines E (1) and F (2) and a new triterpenoid saponin hypoglaside A (3), together with a known diterpenoid glucoside11-O-β-D-glucopyranosyl neotriptophenolide (4) and two known triterpenoids 23-noroxopristimerol(5) and 2,3-dihydroxy-6-oxo-D:A-froedo-24 nor-1,3,5(10),7-oleanatetraen-29-oic acid (6), have been isolated from the root barks of Tripterygiumhypoglaucum. Their structures were elucidated by NMR spectroscopy and MS analysis.Compounds 1–3 were screened for their cytotoxic activities against five cancer celllines, but all of them were inactive.
authors.affiliation: State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China.
authors.forename: Chuang-Jun
authors.initials: CJ
authors.lastname: Li
authors.forename: Fu-Gui
authors.initials: FG
authors.lastname: Xie
authors.forename: Jing-Zhi
authors.initials: JZ
authors.lastname: Yang
authors.forename: Yong-Ming
authors.initials: YM
authors.lastname: Luo
authors.forename: Xiao-Guang
authors.initials: XG
authors.lastname: Chen
authors.forename: Dong-Ming
authors.initials: DM
authors.lastname: Zhang
mesh_terms: D000470:Alkaloids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D006801:Humans; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D024301:Plant Bark / Q000737:chemistry; D018517:Plant Roots / Q000737:chemistry; D011725:Pyridines / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D012503:Saponins / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D012717:Sesquiterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D029757:Tripterygium / Q000737:chemistry*; D014315:Triterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology
chemical_list: D000470:Alkaloids; D000972:Antineoplastic Agents, Phytogenic; D004365:Drugs, Chinese Herbal; D011725:Pyridines; D012503:Saponins; D012717:Sesquiterpenes; D014315:Triterpenes; C577526:hypoglaside A; C577527:hypoglaunine E; C577528:hypoglaunine F