title: Hypothermia induced by adenosine 5'-monophosphate attenuates acute lung injury induced by LPS in rats.
abstract: We have built a rat's model to investigate whether the hypothermia induced by adenosine 5'-monophosphate (5'-AMP) (AIH) could attenuate acute lung injury induced by LPS in rats. We detected the inflammatory cytokine levels in the plasma and bronchoalveolar lavage fluid samples, and we analyzed the pathological changes in the lungs. We have found that AIH can effectively inhibit acute inflammatory reactions and protect the lung from acute injury induced by LPS in rats.
authors.affiliation: Gout Laboratory, The Affiliated Hospital of Medical College Qingdao University, Shandong Provincial Key Laboratory of Metabolic Diseases, 16 Jiangsu Road, Qingdao 266003, China.
authors.forename: Zhimin
authors.initials: Z
authors.lastname: Miao
authors.forename: Shulai
authors.initials: S
authors.lastname: Lu
authors.forename: Na
authors.initials: N
authors.lastname: Du
authors.forename: Weiting
authors.initials: W
authors.lastname: Guo
authors.forename: Jidong
authors.initials: J
authors.lastname: Zhang
authors.forename: Yu
authors.initials: Y
authors.lastname: Song
authors.forename: Xuefeng
authors.initials: X
authors.lastname: Wang
authors.forename: Wei
authors.initials: W
authors.lastname: Ren
authors.forename: Yunlong
authors.initials: Y
authors.lastname: Wang
authors.forename: Tao
authors.initials: T
authors.lastname: Jiang
mesh_terms: D055371:Acute Lung Injury / Q000097:blood / Q000139:chemically induced* / Q000188:drug therapy* / Q000378:metabolism; D000249:Adenosine Monophosphate / Q000627:therapeutic use*; D000818:Animals; D007035:Hypothermia / Q000097:blood / Q000139:chemically induced* / Q000378:metabolism; D016753:Interleukin-10 / Q000097:blood / Q000378:metabolism; D053583:Interleukin-1beta / Q000097:blood / Q000378:metabolism; D015850:Interleukin-6 / Q000097:blood / Q000378:metabolism; D008070:Lipopolysaccharides / Q000633:toxicity*; D051381:Rats; D017208:Rats, Wistar; D014409:Tumor Necrosis Factor-alpha / Q000097:blood / Q000378:metabolism
chemical_list: D053583:Interleukin-1beta; D015850:Interleukin-6; D008070:Lipopolysaccharides; D014409:Tumor Necrosis Factor-alpha; D016753:Interleukin-10; D000249:Adenosine Monophosphate