title: Interleukin-10-819C>T polymorphism contributed to cancer risk: evidence from 29 studies.
abstract: Cytokines are important modulators in the interactions between the host immune system and malignant tumor. Of these, Interleukin-10 (IL-10) is an important immunoregulatory cytokine mainly produced by macrophages and T lymphocytes. To date, a number of studies investigated the role of the IL-10-819C>T polymorphism in the aetiology of cancers of various organs. However, the results of these studies remain inconclusive. So, we carried out a meta-analysis on all eligible case-control studies to estimate the overall cancer risk of IL-10-819C>T polymorphism as well as to quantify the between-study heterogeneity and potential bias. This meta-analysis, including 8157 cases and 10473 controls from 29 published case-control studies, explored the association between a potentially functional polymorphism, -819C>T within the IL-10 promoter region and cancer risk. We used odds ratios (ORs) with 95% confidence intervals (CIs) to assess the strength of the association. The results provided evidence that the IL-10-819C>T polymorphism was associated with a significant decrease in overall cancer risk. In the stratified analyses, the risk remained for studies of "other cancer", smoking-related cancer, Asian populations and hospital-based studies. This meta-analysis identified an evidence of the association between the IL-10-819C>T and cancer risk, especially in "other cancer", smoking-related cancers, Asians and hospital-based studies. Further large case-control studies, especially studies in African population were needed to validate our results.
authors.affiliation: Department of Urology, The Changshu Hospital Affiliated to Suzhou University, Changshu, China.
authors.forename: Qi
authors.initials: Q
authors.lastname: Ding
authors.forename: Bo
authors.initials: B
authors.lastname: Fan
authors.forename: Zhijiang
authors.initials: Z
authors.lastname: Fan
authors.forename: Li
authors.initials: L
authors.lastname: Ding
authors.forename: Feng
authors.initials: F
authors.lastname: Li
authors.forename: Wenjian
authors.initials: W
authors.lastname: Tu
authors.forename: Xiaohua
authors.initials: X
authors.lastname: Jin
authors.forename: Ying
authors.initials: Y
authors.lastname: Shi
authors.forename: Jing
authors.initials: J
authors.lastname: Wang
mesh_terms: D044466:Asian People / Q000235:genetics; D016022:Case-Control Studies; D005787:Gene Frequency; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006801:Humans; D016753:Interleukin-10 / Q000097:blood / Q000235:genetics* / Q000378:metabolism; D015810:Linkage Disequilibrium; D009369:Neoplasms / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D011401:Promoter Regions, Genetic / Q000235:genetics; D012306:Risk; D012907:Smoking
chemical_list: D016753:Interleukin-10