title: Cord blood 25-hydroxyvitamin D levels and the risk of acute lower respiratory tract infection in early childhood.
abstract: OBJECTIVE
  To determine the relationship between cord blood 25-hydroxyvitamin D [25 (OH) D] concentrations and the subsequent risk of acute lower respiratory tract infection (ALRI) in the first 2 years of life.
  
  
  METHODS
  Cord blood from 206 newborns was tested for 25 (OH) D. Medical records covering the first 2 years of life were reviewed, and the diagnosis of ALRI was recorded.
  
  
  RESULTS
  Sixty-two (30.1%) infants developed ALRI in their first 2 years of life, of whom 49 (79%) infants had bronchiolitis and 13 (21%) infants had pneumonia. Concentrations of 25 (OH) D were lower in infants who developed ALRI compared with those did not (p < 0.0001). Vitamin D deficiency was associated with increased risk of ALRI (p = 0.000).
  
  
  CONCLUSIONS
  Low cord blood 25 (OH) D levels are associated with increased risk of ALRI in the first 2 years of life.
authors.affiliation: Department of Pediatrics, Faculty of Medicine, Minia University, Minia, Egypt. walidabdo2020@gmail.com
authors.forename: W A Wahab
authors.initials: WA
authors.lastname: Mohamed
authors.forename: M A
authors.initials: MA
authors.lastname: Al-Shehri
mesh_terms: D000208:Acute Disease; D000367:Age Factors; D002675:Child, Preschool; D005260:Female; D005312:Fetal Blood / Q000378:metabolism*; D005865:Gestational Age; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D016015:Logistic Models; D008297:Male; D008423:Maternal Age; D011446:Prospective Studies; D012141:Respiratory Tract Infections / Q000097:blood* / Q000453:epidemiology; D012307:Risk Factors; D012529:Saudi Arabia / Q000453:epidemiology; D014807:Vitamin D / Q000031:analogs & derivatives* / Q000097:blood
chemical_list: D014807:Vitamin D; C104450:25-hydroxyvitamin D