title: Do SNPs of DRD4 gene predict adult persistence of ADHD in a Chinese sample?
abstract: The dopamine D4 receptor (DRD4) gene has been frequently studied in relation to attention deficit hyperactivity disorder (ADHD) but little is known about the contribution of single nucleotide polymorphisms (SNPs) of the DRD4 gene to the development and persistence of ADHD. In the present study, we examined the association between two SNPs in DRD4 (rs1800955, rs916455) and adult ADHD persistence in a Chinese sample. Subjects (n=193) were diagnosed with ADHD in childhood and reassessed in young adulthood at an affiliated clinic of Peking University Sixth Hospital. Kaplan-Meier survival analyses and Cox proportional hazard models were used to test the association between ADHD remission and alleles of the two SNPs. DRD4 rs916455 C allele carriers were more likely to have persistent ADHD symptoms in adulthood. No significant association was found between rs1800955 allele and the course of ADHD. These newly detected associations between DRD4 polymorphisms and ADHD prognosis in adulthood may help to predict the persistence of childhood ADHD into adulthood.
authors.affiliation: Institute of Mental Health, Peking University (Sixth Hospital, Peking University), Beijing, PR China.
authors.forename: Yueling
authors.initials: Y
authors.lastname: Li
authors.forename: Mary
authors.initials: M
authors.lastname: Baker-Ericzen
authors.forename: Ning
authors.initials: N
authors.lastname: Ji
authors.forename: Weili
authors.initials: W
authors.lastname: Chang
authors.forename: Lili
authors.initials: L
authors.lastname: Guan
authors.forename: Qiujin
authors.initials: Q
authors.lastname: Qian
authors.forename: Yujuan
authors.initials: Y
authors.lastname: Zhang
authors.forename: Stephen V
authors.initials: SV
authors.lastname: Faraone
authors.forename: Yufeng
authors.initials: Y
authors.lastname: Wang
mesh_terms: D000293:Adolescent; D044466:Asian People / Q000235:genetics / Q000523:psychology; D001289:Attention Deficit Disorder with Hyperactivity / Q000208:ethnology / Q000235:genetics*; D002648:Child; D018450:Disease Progression; D005260:Female; D005787:Gene Frequency; D006801:Humans; D053208:Kaplan-Meier Estimate; D008137:Longitudinal Studies; D008297:Male; D020641:Polymorphism, Single Nucleotide; D011379:Prognosis; D016016:Proportional Hazards Models; D050638:Receptors, Dopamine D4 / Q000235:genetics*; D055815:Young Adult
chemical_list: C493599:DRD4 protein, human; D050638:Receptors, Dopamine D4