title: Molecular networks of DYX1C1 gene show connection to neuronal migration genes and cytoskeletal proteins.
abstract: BACKGROUND
  The dyslexia susceptibility 1 candidate 1 (DYX1C1) gene has recently been associated with dyslexia and reading scores in several population samples. The DYX1C1 has also been shown to affect neuronal migration and modulate estrogen receptor signaling.
  
  
  METHODS
  We have analyzed the molecular networks of DYX1C1 by gene expression and protein interaction profiling in a human neuroblastoma cell line.
  
  
  RESULTS
  We find that DYX1C1 can modulate the expression of nervous system development and neuronal migration genes such as RELN and associate with a number of cytoskeletal proteins. We also show by live cell imaging that DYX1C1 regulates cell migration of the human neuroblastoma cell line dependent on its tetratricopeptide repeat and DYX1 protein domains. The DYX1 domain is a novel highly conserved domain identified in this study by multiple sequence alignment of DYX1C1 proteins recovered from a wide range of eukaryotic species.
  
  
  CONCLUSIONS
  Our results contribute to the hypothesis that dyslexia has a developmental neurobiological basis by linking DYX1C1 with many genes involved in neuronal migration disorders.
authors.affiliation: Center for Biosciences, Department of Biosciences and Nutrition, Novum, Karolinska Institutet, Huddinge, Sweden.
authors.forename: Kristiina
authors.initials: K
authors.lastname: Tammimies
authors.forename: Morana
authors.initials: M
authors.lastname: Vitezic
authors.forename: Hans
authors.initials: H
authors.lastname: Matsson
authors.forename: Sylvie
authors.initials: S
authors.lastname: Le Guyader
authors.forename: Thomas R
authors.initials: TR
authors.lastname: Bürglin
authors.forename: Tiina
authors.initials: T
authors.lastname: Ohman
authors.forename: Staffan
authors.initials: S
authors.lastname: Strömblad
authors.forename: Carsten O
authors.initials: CO
authors.lastname: Daub
authors.forename: Tuula A
authors.initials: TA
authors.lastname: Nyman
authors.forename: Juha
authors.initials: J
authors.lastname: Kere
authors.forename: Isabel
authors.initials: I
authors.lastname: Tapia-Páez
mesh_terms: D002460:Cell Line; D002465:Cell Movement / Q000235:genetics*; D003598:Cytoskeletal Proteins / Q000235:genetics* / Q000378:metabolism; D005786:Gene Expression Regulation / Q000235:genetics; D006801:Humans; D009419:Nerve Tissue Proteins / Q000235:genetics* / Q000378:metabolism; D055495:Neurogenesis / Q000235:genetics; D009474:Neurons / Q000166:cytology* / Q000378:metabolism*; D009687:Nuclear Proteins / Q000235:genetics* / Q000378:metabolism; D060066:Protein Interaction Maps / Q000235:genetics; D000091042:Reelin Protein; D059467:Transcriptome / Q000235:genetics
chemical_list: D003598:Cytoskeletal Proteins; C478878:DNAAF4 protein, human; D009419:Nerve Tissue Proteins; D009687:Nuclear Proteins; D000091042:Reelin Protein; C000717127:RELN protein, human