title: Reveals new lung adenocarcinoma cancer genes based on gene expression.
abstract: BACKGROUND
  Lung adenocarcinoma (LAC) is the most common type of lung cancer, accounting for 30-35% of all cases.
  
  
  OBJECTIVE
  In this study we aim to predict potential genes and confirm pathways which are associated with LAC.
  
  
  METHODS
  By using the meta-analysis method, GSE10072 and GSE 2514 datasets were merged to find potential genes and pathways which are associated with LAC.
  
  
  RESULTS
  Our analysis indicated identified differentially expressed genes enriched in multicellular organismal metabolic process, gland development, and urogenital system development. Further, we predicted genes including EGF-like domain might be the potential target genes for further study, such as NGX6, MUC17, and Nel. In addition, a number of genes that associated with axon guidance, focal adhesion, and complement and coagulation cascades pathway might be also involved in LAC in a direct or indirectly manner.
  
  
  CONCLUSIONS
  Our analysis indicated identified differentially expressed genes enriched in multicellular organismal metabolic process, gland development, and urogenital system development We anticipate numerous advances in LAC research in the coming years based on our meta-analysis.
authors.affiliation: Department of Thoracic Surgery, Shanghai Jiaotong University, Shanghai, China. linzhifeng2611@163.com
authors.forename: Z-F
authors.initials: ZF
authors.lastname: Lin
authors.forename: X-Y
authors.initials: XY
authors.lastname: Shen
authors.forename: F-Z
authors.initials: FZ
authors.lastname: Lu
authors.forename: Z
authors.initials: Z
authors.lastname: Ruan
authors.forename: H-L
authors.initials: HL
authors.lastname: Huang
authors.forename: J
authors.initials: J
authors.lastname: Zhen
mesh_terms: D000230:Adenocarcinoma / Q000235:genetics*; D000077192:Adenocarcinoma of Lung; D015815:Cell Adhesion Molecules / Q000235:genetics; D058851:GPI-Linked Proteins / Q000235:genetics; D020869:Gene Expression Profiling; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D006821:Hyaluronoglucosaminidase / Q000235:genetics; D008175:Lung Neoplasms / Q000235:genetics*; D008562:Membrane Glycoproteins / Q000235:genetics; D000072636:PAX8 Transcription Factor; D051761:Paired Box Transcription Factors / Q000235:genetics; D039961:Semaphorins / Q000235:genetics
chemical_list: D015815:Cell Adhesion Molecules; D058851:GPI-Linked Proteins; D008562:Membrane Glycoproteins; D000072636:PAX8 Transcription Factor; C083325:PAX8 protein, human; D051761:Paired Box Transcription Factors; C409766:SEMA3B protein, human; D039961:Semaphorins; C473096:Hyal2 protein, human; D006821:Hyaluronoglucosaminidase