title: Indole alkaloids from Kopsia hainanensis and evaluation of their antimicrobial activity.
abstract: Three new indole alkaloids, named kopsihainin D (1), kopsihainin E (2), and kopsihainin F (3), along with nine known compounds (4-12) were isolated from the twigs of Kopsia hainanensis. The structures of the new compounds were elucidated by spectroscopic methods including HRESIMS, UV, IR, and NMR. Compounds 1 - 3 and 5 showed inhibitory activity against Staphylococcus aureus with an antibacterial circle diameter of 11.2, 9.1, 10.3 and 9.7 mm, respectively.
authors.affiliation: Hainan Key Laboratory for Research and Development of Natural Products from Li Folk Medicine, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou, Hainan, P R China.
authors.forename: Yong
authors.initials: Y
authors.lastname: Yang
authors.forename: Wen-Jian
authors.initials: WJ
authors.lastname: Zuo
authors.forename: You-Xing
authors.initials: YX
authors.lastname: Zhao
authors.forename: Wen-Hua
authors.initials: WH
authors.lastname: Dong
authors.forename: Wen-Li
authors.initials: WL
authors.lastname: Mei
authors.forename: Hao-Fu
authors.initials: HF
authors.lastname: Dai
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D029062:Apocynaceae / Q000737:chemistry*; D004365:Drugs, Chinese Herbal / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D026121:Indole Alkaloids / Q000302:isolation & purification* / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D018547:Plant Stems / Q000737:chemistry; D013211:Staphylococcus aureus / Q000187:drug effects*
chemical_list: D000900:Anti-Bacterial Agents; D004365:Drugs, Chinese Herbal; D026121:Indole Alkaloids