title: Three-component domino reactions for selective formation of indeno[1,2-b]indole derivatives.
abstract: Efficient three-component domino strategies for the synthesis of multifunctionalized tetracyclic indeno[1,2-b]indole derivatives with different substituted patterns have been established successfully. The first pathway involves a novel sequential methyl migration, aromatization, and esterification, while a second reaction in HOAc leads to compounds 6 with high syn diastereoselectivity. Both reactions showed attractive features including mild conditions, convenient one-pot operation, short reaction times of 15-32 min, and excellent regio- and/or stereoselectivity.
authors.affiliation: School of Chemistry and Chemical Engineering, and Jiangsu Key Laboratory of Green Synthetic Chemistry for Functional Materials, Jiangsu Normal University, Xuzhou, 221116, Jiangsu, PR China.
authors.forename: Bo
authors.initials: B
authors.lastname: Jiang
authors.forename: Qiu-Yun
authors.initials: QY
authors.lastname: Li
authors.forename: Shu-Jiang
authors.initials: SJ
authors.lastname: Tu
authors.forename: Guigen
authors.initials: G
authors.lastname: Li
mesh_terms: D007211:Indoles / Q000138:chemical synthesis*; D008958:Models, Molecular; D015394:Molecular Structure; D013237:Stereoisomerism
chemical_list: D007211:Indoles; C057286:indenoindole