title: Combination of poly L-lactic acid nanofiber scaffold with omentum graft for bone healing in experimental defect in tibia of rabbits.
abstract: OBJECTIVE
  To investigate the osteoconductive properties and biological performance of Poly L-lactic acid (PLLA) with omentum in bone defects.
  
  
  METHODS
  PLLA nanofiber scaffolds were prepared via electrospinning technique. Forty four New Zealand white female rabbits randomly divided into three groups of 18 rabbits each. Created defects in right tibias were filled in group I with omentum, in group II with PLLA nanofiber scaffold and in group III with combination of the omentum and PLLA. The same defects were created in left tibia of all groups but did not receive any treatment (control group). Histological and histomorphometric evaluations were performed at two, four and six weeks after the implantation.
  
  
  RESULTS
  Histological changes on all groups along with the time course were scored and statistical analysis showed that the average scores in group III were significantly higher than the other groups.
  
  
  CONCLUSIONS
  Histomorphometric analysis of bone healing was shown to be significantly improved by the combined PLLA with omentum compared with the other groups, suggesting this biomaterial promote the healing of cortical bone, presumably by acting as an osteoconductive scaffold.
authors.affiliation: Department of Veterinary Science, Kahnooj Branch, Islamic Azad University, Kerman, Iran. dramirsotoudeh@kahnoojiau.ac.ir
authors.forename: Amir
authors.initials: A
authors.lastname: Sotoudeh
authors.forename: Gholamreza
authors.initials: G
authors.lastname: Jahanshahi
authors.forename: Amirali
authors.initials: A
authors.lastname: Jahanshahi
authors.forename: Mohammad Ashrafzadeh
authors.initials: MA
authors.lastname: Takhtfooladi
authors.forename: Iman
authors.initials: I
authors.lastname: Shabani
authors.forename: Masoud
authors.initials: M
authors.lastname: Soleimani
mesh_terms: D000818:Animals; D001672:Biocompatible Materials / Q000627:therapeutic use; D001861:Bone Regeneration / Q000187:drug effects*; D005260:Female; D019344:Lactic Acid / Q000627:therapeutic use*; D008422:Materials Testing; D008855:Microscopy, Electron, Scanning; D023421:Models, Animal; D057139:Nanofibers / Q000627:therapeutic use*; D009852:Omentum / Q000637:transplantation*; D011091:Polyesters; D011108:Polymers / Q000627:therapeutic use*; D011817:Rabbits; D013977:Tibia / Q000293:injuries*; D013997:Time Factors; D054457:Tissue Scaffolds; D016896:Treatment Outcome; D014945:Wound Healing / Q000187:drug effects*
chemical_list: D001672:Biocompatible Materials; D011091:Polyesters; D011108:Polymers; D019344:Lactic Acid; C033616:poly(lactide)