title: [Effect of combined therapy with melaxen on lipid peroxidation rate and citrate content in blood serum of patients with drug-induced hepatitis diagnosis].
abstract: A combined therapy with melaxen led to a decrease in the activity of gamma-glutamyl transpeptidase and the level of diene conjugates in blood serum of patients with the drug-induced hepatitis developing on the background of administration of antituberculous preparations. These changes are indicative of pronounced antioxidant and hepatoprotective properties of the drug. In addition, there was a decrease in the content of citrate and a change in the activity of aconitate hydratase toward a normal level, which reflects a decrease in the degree of pathologic oxidative stress development and is evidence of the antiradical effect of melaxen.
authors.forename: S S
authors.initials: SS
authors.lastname: Popov
authors.forename: K K
authors.initials: KK
authors.lastname: Shul'gin
authors.forename: A N
authors.initials: AN
authors.lastname: Pashkov
authors.forename: V I
authors.initials: VI
authors.lastname: Zoloedov
authors.forename: G I
authors.initials: GI
authors.lastname: Shvedov
mesh_terms: D000154:Aconitate Hydratase / Q000097:blood; D000328:Adult; D000368:Aged; D000904:Antibiotics, Antitubercular / Q000008:administration & dosage / Q000009:adverse effects; D000975:Antioxidants / Q000008:administration & dosage*; D056486:Chemical and Drug Induced Liver Injury / Q000097:blood* / Q000188:drug therapy*; D019343:Citric Acid / Q000097:blood; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D015227:Lipid Peroxidation / Q000187:drug effects; D008297:Male; D008550:Melatonin / Q000008:administration & dosage*; D008875:Middle Aged; D018384:Oxidative Stress / Q000187:drug effects; D005723:gamma-Glutamyltransferase / Q000097:blood
chemical_list: D000904:Antibiotics, Antitubercular; D000975:Antioxidants; D019343:Citric Acid; D005723:gamma-Glutamyltransferase; D000154:Aconitate Hydratase; D008550:Melatonin