title: Congenital mesoblastic nephroma in a young basset hound dog.
abstract: An 18-month-old male basset hound was presented with vomiting, diarrhoea and depression. Abdominal ultrasonography revealed a mass in the left kidney. An ultrasound-guided core-biopsy indicated aggregates of spindle cells, but did not allow a definitive diagnosis. Nephrectomy was performed after a period of six months, when ultrasound examination revealed a slight increase in mass dimensions. Histologically the mass was composed of neoplastic spindle cells forming interlacing fascicles, bundles and whorls, within a loose myxoid to dense collagenous stroma. Immunohistochemically neoplastic cells were positive for vimentin and smooth muscle actin. Based on these findings the tumour was diagnosed as a congenital mesoblastic nephroma, classical variant. After a two-and-a-half-year follow-up the dog was clinically healthy, indicating a benign behaviour. To the authors' knowledge, this report describes the first case of canine congenital mesoblastic nephroma successfully treated surgically, with a reasonable postsurgical follow-up.
authors.affiliation: IDEXX-Diavet, Division of IDEXX Laboratories, Diavet-Labor AG, Bäch, Switzerland.
authors.forename: S
authors.initials: S
authors.lastname: Soldati
authors.forename: E
authors.initials: E
authors.lastname: Radaelli
authors.forename: A
authors.initials: A
authors.lastname: Mazzuti
authors.forename: E
authors.initials: E
authors.lastname: Scanziani
mesh_terms: D000818:Animals; D004283:Dog Diseases / Q000151:congenital* / Q000175:diagnosis / Q000601:surgery; D004285:Dogs; D007150:Immunohistochemistry / Q000662:veterinary; D007680:Kidney Neoplasms / Q000151:congenital / Q000175:diagnosis / Q000601:surgery / Q000662:veterinary*; D008297:Male; D018201:Nephroma, Mesoblastic / Q000175:diagnosis / Q000601:surgery / Q000662:veterinary*