title: [Nuclear envelope attachment sites of interphase chromosomes: barrier elements but not insulators].
abstract: A neDNA fragment that protects a transgene from position effect variegation when flanking it was tested for insulator properties. The fragment did not act as an insulator. A similarity of neDNA and various barrier elements was examined, and Drosophila melanogaster and Mus musculus chromosome DNA regions homologous to neDNA were analyzed. Additional conserved sites and DNA duplex destabilization sites were found in the neDNA sequence, and DNA conformational specifics were assumed for the chromosomal neighborhood of neDNA sites of the D. melanogaster and M. musculus genomes.
authors.forename: A N
authors.initials: AN
authors.lastname: Shabarina
authors.forename: M V
authors.initials: MV
authors.lastname: Glazkov
mesh_terms: D000818:Animals; D030801:Animals, Genetically Modified; D001483:Base Sequence / Q000235:genetics; D055012:Chromosomal Position Effects / Q000235:genetics; D002875:Chromosomes / Q000235:genetics*; D017124:Conserved Sequence / Q000235:genetics; D004247:DNA / Q000235:genetics*; D004331:Drosophila melanogaster / Q000235:genetics*; D005786:Gene Expression Regulation; D038101:Insulator Elements / Q000235:genetics; D007399:Interphase / Q000235:genetics; D051379:Mice; D009685:Nuclear Envelope / Q000235:genetics*; D009690:Nucleic Acid Conformation
chemical_list: D004247:DNA