title: Association of KCNE1 genetic polymorphisms with atrial fibrillation in a Chinese Han population.
abstract: OBJECTIVE
  The purpose of this study was to investigate the association of the polymorphisms of the KCNE1 gene with atrial fibrillation (AF) in a Chinese Han population.
  
  
  METHODS
  Three hundred seven AF patients and 330 age- and sex-matched controls were genotyped using the polymerase chain reaction-restriction fragment length polymorphism method for two single-nucleotide polymorphisms (rs1805127 and rs1892593) of the human KCNE1 gene.
  
  
  RESULTS
  The frequencies of the AA, AG, and GG genotypes of rs1805127 were 11.7%, 50.0%, and 43.3%, respectively, in the AF group, whereas the ones in the control group had frequencies of 19.4%, 44.9%, and 35.8%, respectively. There were significant differences in frequencies of these three genotypes (χ(2)=7.820, p=0.016) and G allele (65.8% vs. 58.2%; χ(2)=8.266, p=0.005). The frequencies of AA, AG, and GG of rs1892593 were 38.4%, 47.9%, and 13.7% in the AF group, whereas the ones in the control group had frequencies of 37.8%, 48.5%, and 14.0%, respectively. There was no difference in distributions of frequencies of these three genotypes and allele (χ(2)=0.051, p=0.978; χ(2)=1.024, p=0.837, respectively) between AF patients and control subjects. We also found that rs1805127 was associated with left atrial diameter and left ventricular end diastolic diameter in AF patients (χ(2)=24.883, p<0.001; χ(2)=34.901, p<0.001, respectively). Logistic regression analysis showed that rs1805127 was an independent risk factor of AF in a Chinese Han population (odds ratio [OR]=1.66, 95% confidence interval [CI]: 1.02-2.68 for AG; OR=2.03, 95% CI: 1.24-3.31 for GG).
  
  
  CONCLUSIONS
  The genetic polymorphism of KCNE1 was associated with increased risk of AF in a Chinese Han population.
authors.affiliation: Department of Cardiology, First Affiliated Hospital of Xinjiang Medical University, Urumqi, P.R. China.
authors.forename: Juan
authors.initials: J
authors.lastname: Yao
authors.forename: Yi-Tong
authors.initials: YT
authors.lastname: Ma
authors.forename: Xiang
authors.initials: X
authors.lastname: Xie
authors.forename: Fen
authors.initials: F
authors.lastname: Liu
authors.forename: Bang-Dang
authors.initials: BD
authors.lastname: Chen
mesh_terms: D000368:Aged; D000483:Alleles; D044466:Asian People; D001281:Atrial Fibrillation / Q000208:ethnology / Q000235:genetics*; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic; D024642:Potassium Channels, Voltage-Gated / Q000235:genetics*
chemical_list: C489622:KCNE1 protein, human; D024642:Potassium Channels, Voltage-Gated