title: Cord blood S100B levels in low-risk term pregnancies with meconium-stained amniotic fluid.
abstract: OBJECTIVE
  The aim of this study was to compare cord blood S100B levels and cord blood gas parameters of term infants with meconium-stained amniotic fluid (MSAF) to those infants with clear amniotic fluid.
  
  
  METHODS
  Term pregnant women at an active phase of labor and having MSAF were defined as the study group (n = 35) and pregnant women with clear amniotic fluid, and matched for age, parity, and gestational age were defined as the control group (n = 35). Cord blood S100B levels and gas parameters were measured.
  
  
  RESULTS
  LogS100B values of study and control groups were 2.40 ± 0.21 and 2.43 ± 0.29 pg/ml, respectively. The difference was not statistically significant (p = 0.675). LogS100B levels slightly increased as meconium thickened. (2.32 ± 0.16, 2.41 ± 0.17, and 2.44 ± 0.28 pg/ml, respectively). However, no difference was found between groups (p = 0.438). Moreover, the study group had a statistically lower HCO(3) level (21.80 vs 23.60 mmol/l) and a higher rate of base deficit (4.85 vs 3.25 mmol/l) than the control group. However, median HCO(3) and base deficit values were within normal limits in both groups.
  
  
  CONCLUSIONS
  The present study showed that cord blood S100B levels of infants born through MSAF were not different from those with clear amniotic fluid. This finding suggests that MSAF, regardless of its thickness, may not be related to brain damage in low risk term pregnancies.
authors.affiliation: Department of Obstetrics & Gynecology, Fatih University, Faculty of Medicine, Ankara, Turkey. denizhizli@yahoo.com
authors.forename: Deniz
authors.initials: D
authors.lastname: Hızlı
authors.forename: Sadıman Kıykaç
authors.initials: SK
authors.lastname: Altınbaş
authors.forename: Aydın
authors.initials: A
authors.lastname: Köşüş
authors.forename: Nermin
authors.initials: N
authors.lastname: Köşüş
authors.forename: Sema
authors.initials: S
authors.lastname: Uysal
authors.forename: Servet
authors.initials: S
authors.lastname: Hacıvelioğlu
authors.forename: Orhan
authors.initials: O
authors.lastname: Gelişen
authors.forename: Hasan
authors.initials: H
authors.lastname: Kafalı
mesh_terms: D000328:Adult; D000653:Amniotic Fluid / Q000378:metabolism*; D001639:Bicarbonates / Q000032:analysis / Q000097:blood; D001784:Blood Gas Analysis; D016022:Case-Control Studies; D005260:Female; D005312:Fetal Blood / Q000737:chemistry* / Q000378:metabolism; D006801:Humans; D007231:Infant, Newborn; D008470:Meconium / Q000378:metabolism*; D008471:Meconium Aspiration Syndrome / Q000097:blood / Q000175:diagnosis / Q000378:metabolism; D009414:Nerve Growth Factors / Q000032:analysis / Q000097:blood*; D011247:Pregnancy; D012307:Risk Factors; D064568:S100 Calcium Binding Protein beta Subunit; D009418:S100 Proteins / Q000032:analysis / Q000097:blood*; D047929:Term Birth / Q000097:blood* / Q000502:physiology; D055815:Young Adult
chemical_list: D001639:Bicarbonates; D009414:Nerve Growth Factors; D064568:S100 Calcium Binding Protein beta Subunit; D009418:S100 Proteins; C579160:S100B protein, human