title: Iron-catalyzed N-alkylation of azoles via cleavage of an sp3 C-H bond adjacent to a nitrogen atom.
abstract: Iron-catalyzed direct C-N bond formation between azoles and amides is described. The oxidative coupling reactions of sp(3) C-H bonds adjacent to a nitrogen atom in amides and sulfonamides with the N-H bond in azoles proceeded smoothly in the presence of FeCl(2) and di-tert-butyl peroxide (DTBP).
authors.affiliation: Department of Chemistry, Zhejiang University, Xixi Campus, Hangzhou 310028, People's Republic of China.
authors.forename: Qinqin
authors.initials: Q
authors.lastname: Xia
authors.forename: Wanzhi
authors.initials: W
authors.lastname: Chen
mesh_terms: D000478:Alkylation; D000577:Amides / Q000737:chemistry*; D001393:Azoles / Q000737:chemistry*; D002384:Catalysis; D005296:Ferrous Compounds / Q000737:chemistry*; D015394:Molecular Structure; D009584:Nitrogen / Q000737:chemistry*
chemical_list: D000577:Amides; D001393:Azoles; D005296:Ferrous Compounds; D009584:Nitrogen; C029451:ferrous chloride