title: The functional anatomy of non-verbal (pitch memory) function in left and right anterior temporal lobectomy patients.
abstract: An fMRI pitch memory task was administered to left and right anterior temporal lobectomy (ATL) patients. The goal was to verify the neuroanatomical correlates of non-verbal memory, and to determine if pitch memory tasks can identify cognitive risk prior to ATL. The data showed that the bilateral posterior superior temporal lobes implement pitch memory in both ATL patients and NCs (normal controls), indicating that the task can be accomplished with either anterior temporal lobe resected. NCs activate the posterior temporal lobes more strongly than ATL patients during highly accurate performance. In contrast, both ATL groups activate the anterior cingulate in association with accuracy. While our data clarifies the functional neuroanatomy of pitch memory, it also indicates that such tasks do not serve well to lateralize and functionally map potentially "at risk" non-verbal memory skills prior to ATL.
authors.affiliation: Department of Neurology, Thomas Jefferson University/Jefferson Medical College, Philadelphia, PA 19107, USA. joseph.i.tracy@jefferson.edu
authors.forename: Joseph I
authors.initials: JI
authors.lastname: Tracy
authors.forename: R Nick
authors.initials: RN
authors.lastname: Hernandez
authors.forename: Sonal
authors.initials: S
authors.lastname: Mayekar
authors.forename: Karol
authors.initials: K
authors.lastname: Osipowicz
authors.forename: Brian
authors.initials: B
authors.lastname: Corbett
authors.forename: Mark
authors.initials: M
authors.lastname: Pascua
authors.forename: Michael R
authors.initials: MR
authors.lastname: Sperling
authors.forename: Ashwini D
authors.initials: AD
authors.lastname: Sharan
mesh_terms: D000161:Acoustic Stimulation; D000328:Adult; D038481:Anterior Temporal Lobectomy / Q000009:adverse effects*; D003627:Data Interpretation, Statistical; D004522:Educational Status; D004833:Epilepsy, Temporal Lobe / Q000601:surgery; D005260:Female; D007839:Functional Laterality; D006801:Humans; D007091:Image Processing, Computer-Assisted; D007600:Judgment; D020232:Kluver-Bucy Syndrome / Q000523:psychology*; D008279:Magnetic Resonance Imaging; D008297:Male; D008568:Memory / Q000502:physiology*; D008875:Middle Aged; D010897:Pitch Discrimination / Q000502:physiology*; D011597:Psychomotor Performance / Q000502:physiology; D021641:Recognition, Psychology / Q000502:physiology; D013702:Temporal Lobe / Q000033:anatomy & histology* / Q000502:physiology*