title: Serum and dietary magnesium and incidence of atrial fibrillation in whites and in African Americans--Atherosclerosis Risk in Communities (ARIC) study.
abstract: BACKGROUND
  Low serum magnesium (Mg) has been associated with an increased risk of cardiovascular disease (CVD), including ventricular arrhythmias, but the association between serum or dietary Mg and atrial fibrillation (AF) has not been investigated.
  
  
  RESULTS
  A total of 14,290 men and women (75% white; 53% female; mean age, 54 years) free of AF at baseline participating in the Atherosclerosis Risk in Communities study in the United States, were studied. Incident AF cases through 2009 were ascertained from electrocardiograms, hospital discharge codes, and death certificates. Multivariate Cox proportional hazards regression was used to estimate hazard ratios (HR) and 95% confidence intervals (CI) for AF associated with serum and dietary Mg quintiles. Over a median follow-up time of 20.6 years, 1,755 incident AF cases were identified. In multivariate models, lower serum Mg was associated with higher AF risk: compared to individuals in the middle quintile (≥ 0.80-0.83 mmol/L), the HR (95% CI) of AF in quintiles 1, 2, 4, and 5 were 1.34 (1.16-1.54), 0.99 (0.85-1.16), 1.04 (0.90-1.22), and 1.06 (0.91-1.23), respectively. There was no evidence of significant interactions between serum Mg and sex or race. No association between dietary Mg and AF risk was observed.
  
  
  CONCLUSIONS
  Lower serum Mg was associated with a higher AF risk, and this association was not different between whites and African Americans. Dietary Mg was not associated with AF risk.
authors.affiliation: Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, MN 55454, USA.misi0020@umn.edu
authors.forename: Jeffrey R
authors.initials: JR
authors.lastname: Misialek
authors.forename: Faye L
authors.initials: FL
authors.lastname: Lopez
authors.forename: Pamela L
authors.initials: PL
authors.lastname: Lutsey
authors.forename: Rachel R
authors.initials: RR
authors.lastname: Huxley
authors.forename: James M
authors.initials: JM
authors.lastname: Peacock
authors.forename: Lin Y
authors.initials: LY
authors.lastname: Chen
authors.forename: Elsayed Z
authors.initials: EZ
authors.lastname: Soliman
authors.forename: Sunil K
authors.initials: SK
authors.lastname: Agarwal
authors.forename: Alvaro
authors.initials: A
authors.lastname: Alonso
mesh_terms: D001741:Black or African American / Q000706:statistics & numerical data*; D050197:Atherosclerosis / Q000178:diet therapy / Q000208:ethnology* / Q000378:metabolism; D001281:Atrial Fibrillation / Q000178:diet therapy* / Q000208:ethnology* / Q000378:metabolism; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D015994:Incidence; D008274:Magnesium / Q000008:administration & dosage / Q000097:blood*; D008297:Male; D008875:Middle Aged; D016016:Proportional Hazards Models; D011446:Prospective Studies; D012111:Residence Characteristics; D012307:Risk Factors; D017678:Sex Distribution; D014481:United States / Q000453:epidemiology; D044465:White People / Q000706:statistics & numerical data*
chemical_list: D008274:Magnesium