title: Integrating insulin secretion and ER stress in pancreatic β-cells.
abstract: After food consumption, insulin-secreting pancreatic β-cells detect increased glucose and incretin hormones, and respond by releasing insulin. Wolfram syndrome 1, a protein that mitigates endoplasmic reticulum (ER) stress, is now shown to regulate insulin synthesis and release--revealing a molecular point of convergence between the ER stress and insulin release pathways.
authors.forename: Katleen
authors.initials: K
authors.lastname: Lemaire
authors.forename: Frans
authors.initials: F
authors.lastname: Schuit
mesh_terms: D000818:Animals; D059865:Endoplasmic Reticulum Stress / Q000502:physiology*; D006801:Humans; D007328:Insulin / Q000378:metabolism*; D000078790:Insulin Secretion; D050417:Insulin-Secreting Cells / Q000378:metabolism*; D008565:Membrane Proteins / Q000378:metabolism; D051379:Mice; D051381:Rats
chemical_list: D007328:Insulin; D008565:Membrane Proteins; C114987:wolframin protein