title: Temperature-sensitive polymer-coated magnetic nanoparticles as a potential drug delivery system for targeted therapy of thyroid cancer.
abstract: The objective of this work was to develop and investigate temperature-sensitive poly(N-isopropylacrylamide-acrylamide-allylamine)-coated iron oxide magnetic nanoparticles (TPMNPs) as possible targeted drug carriers for treatments of advanced thyroid cancer (ATC). These nanoparticles were prepared by free radical polymerization of monomers on the surface of silane-coupled iron oxide nanoparticles. In vitro studies demonstrated that TPMNPs were cytocompatible and effectively taken up by cancer cells in a dose-dependent manner. An external magnetic field significantly increased nanoparticle uptake, especially when cells were exposed to physiological flow conditions. Drug loading and release studies using doxorubicin confirmed the temperature-responsive release of drugs from nanoparticles. In addition, doxorubicin-loaded nanoparticles significantly killed ATC cells when compared to free doxorubicin. The in vitro results indicate that TPMNPs have potential as targeted and controlled drug carriers for thyroid cancer treatment.
authors.affiliation: Department of Bioengineering, University of Texas at Arlington, Arlington, TX 76019, USA.
authors.forename: Bhanuprasanth
authors.initials: B
authors.lastname: Koppolu
authors.forename: Zarna
authors.initials: Z
authors.lastname: Bhavsar
authors.forename: Aniket S
authors.initials: AS
authors.lastname: Wadajkar
authors.forename: Sivaniarvindpriya
authors.initials: S
authors.lastname: Nattama
authors.forename: Maham
authors.initials: M
authors.lastname: Rahimi
authors.forename: Fiemu
authors.initials: F
authors.lastname: Nwariaku
authors.forename: Kytai T
authors.initials: KT
authors.lastname: Nguyen
mesh_terms: D002460:Cell Line; D045744:Cell Line, Tumor; D004305:Dose-Response Relationship, Drug; D004337:Drug Carriers; D016503:Drug Delivery Systems; D005347:Fibroblasts / Q000166:cytology; D006801:Humans; D060526:Magnetic Fields; D008280:Magnetics; D053758:Nanoparticles / Q000737:chemistry*; D011108:Polymers / Q000737:chemistry*; D013696:Temperature; D013964:Thyroid Neoplasms / Q000628:therapy*; D013997:Time Factors
chemical_list: D004337:Drug Carriers; D011108:Polymers