title: Evaluation of anti-nociceptive activity of methanolic extract of Tecomaria capensis Thunb. (Bignoniaceae) leaves in rats.
abstract: OBJECTIVE
  To evaluate the anti-nociceptive activity of Tecomaria capensis (T. capensis) leaves extract (TCLE) using different models in rats by acetic acid induced writhing test, (b) tail-flick test (c) tail-clip test.
  
  
  METHODS
  TCLE (100, 300, 1000 and 2000 mg/kg body wt.) was given to rats orally to observe acute toxicity for 14 d. Then test drug TCLE were given at dose of 100, 200 and 500 mg/kg p.o. and standard drug aspirin were given at a dose of 100 mg/kg p.o.
  
  
  RESULTS
  No mortality was reported even after 14 d. This indicates that the methanol extract is safe up to a single dose of 2 000 mg/kg body weight. TCLE (100, 200 and 500 mg/kg p.o.) significantly inhibited abdominal constrictions (writhing) induced by acetic acid and increased the latency period in the tail flick and tail clip test. TCLE at the dose of 500 mg/kg showed significant anti-nociceptive activity compared to standard aspirin.
  
  
  CONCLUSIONS
  The results of this study show that methanol extract of T. capensis possesses anti-nociceptive activity which may be mediated by the central and peripheral mechanisms.
authors.affiliation: Department of Pharmacology, Jaipur National University, Jaipur, India. pharmaniraj@hotmail.com
authors.forename: N K
authors.initials: NK
authors.lastname: Saini
authors.forename: M
authors.initials: M
authors.lastname: Singhal
mesh_terms: D019342:Acetic Acid; D000700:Analgesics / Q000494:pharmacology*; D000818:Animals; D001241:Aspirin / Q000494:pharmacology*; D029402:Bignoniaceae / Q000737:chemistry*; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D005260:Female; D008297:Male; D000432:Methanol; D010146:Pain / Q000139:chemically induced / Q000188:drug therapy*; D008517:Phytotherapy; D010936:Plant Extracts / Q000494:pharmacology; D018515:Plant Leaves; D051381:Rats
chemical_list: D000700:Analgesics; D010936:Plant Extracts; D019342:Acetic Acid; D001241:Aspirin; D000432:Methanol