title: Volumetric and functional assessment of ventricles in pulmonary hypertension on 3-dimensional echocardiography.
abstract: BACKGROUND
  Non-invasive assessment of volume and function on the right ventricle (RV) for pulmonary hypertension (PH) is limited.
  
  
  RESULTS
  Patients with PH (n=23) underwent 3-dimensional (D) echocardiography (3DECHO), with cardiac magnetic resonance imaging to confirm its precision, and right heart catheterization. On linear regression analysis the RV end-systolic volume index (ESVI) was positively correlated with pulmonary vascular resistance (PVR) and mean pulmonary arterial pressure (mPAP; R=0.42 and 0.46, P=0.03 and 0.03, respectively). The RV end-diastolic volume index (EDVI) was positively correlated with mPAP (R=0.41, P<0.05). The left ventricular (LV) EDVI was inversely correlated with PVR (R=-0.48, P=0.02). The RV ejection fraction was inversely correlated with PVR and mean right atrial pressure (mRAP; R=-0.57, and -0.45, P=0.004, and 0.03, respectively). RVEDVI/LVEDVI and RVESVI/LVESVI (the diastolic and systolic remodeling indices, respectively) had a significantly positive linear relationship with PVR (R=0.67 and 0.55, P=0.0005 and 0.006, respectively), and the former had a significantly positive linear relationship with mRAP (R=0.42, P<0.05). During the recovery process in 1 specific case, the remodeling indices maintained a significant linear relationship with the hemodynamic parameters.
  
  
  CONCLUSIONS
  Novel indices provided by 3DECHO may be utilized as alternative indicators of hemodynamic changes in PH patients.
authors.affiliation: Department of Cardiovascular Medicine, Graduate School of Medicine, University of Tokyo, Tokyo, Japan.
authors.forename: Toshiro
authors.initials: T
authors.lastname: Inaba
authors.forename: Atsushi
authors.initials: A
authors.lastname: Yao
authors.forename: Tomoko
authors.initials: T
authors.lastname: Nakao
authors.forename: Masaru
authors.initials: M
authors.lastname: Hatano
authors.forename: Hisataka
authors.initials: H
authors.lastname: Maki
authors.forename: Teruhiko
authors.initials: T
authors.lastname: Imamura
authors.forename: Taro
authors.initials: T
authors.lastname: Shiga
authors.forename: Tadashi
authors.initials: T
authors.lastname: Yamazaki
authors.forename: Makoto
authors.initials: M
authors.lastname: Sonoda
authors.forename: Koichiro
authors.initials: K
authors.lastname: Kinugawa
authors.forename: Takahiro
authors.initials: T
authors.lastname: Shiota
authors.forename: Junichi
authors.initials: J
authors.lastname: Suzuki
authors.forename: Katsu
authors.initials: K
authors.lastname: Takenaka
authors.forename: Yasunobu
authors.initials: Y
authors.lastname: Hirata
authors.forename: Ryozo
authors.initials: R
authors.lastname: Nagai
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D019560:Echocardiography, Three-Dimensional; D005260:Female; D006352:Heart Ventricles / Q000000981:diagnostic imaging / Q000503:physiopathology; D006801:Humans; D006976:Hypertension, Pulmonary / Q000000981:diagnostic imaging / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D013318:Stroke Volume; D014655:Vascular Resistance; D016278:Ventricular Function, Right; D020257:Ventricular Remodeling