title: Dietary modification of metabolic pathways via nuclear hormone receptors.
abstract: Nuclear hormone receptors (NHRs), as ligand-dependent transcription factors, have emerged as important mediators in the control of whole body metabolism. Because of the promiscuous nature of several members of this superfamily that have been found to bind ligand with lower affinity than the classical steroid NHRs, they consequently display a broader ligand selectivity. This promiscuous nature has facilitated various bioactive dietary components being able to act as agonist ligands for certain members of the NHR superfamily. By binding to these NHRs, bioactive dietary components are able to mediate changes in various metabolic pathways, including, glucose, cholesterol and triglyceride homeostasis among others. This review will provide a general overview of the nuclear hormone receptors that have been shown to be activated by dietary components. The physiological consequences of such receptor activation by these dietary components will then be discussed in more detail.
authors.affiliation: Department of Agriculture, Nutrition and Veterinary Sciences, University of Nevada Reno, Reno, NV 89557, USA.
authors.forename: Gianella
authors.initials: G
authors.lastname: Caiozzi
authors.forename: Brian S
authors.initials: BS
authors.lastname: Wong
authors.forename: Marie-Louise
authors.initials: ML
authors.lastname: Ricketts
mesh_terms: D000818:Animals; D003474:Curcumin / Q000378:metabolism; D004224:Diterpenes / Q000378:metabolism; D005419:Flavonoids / Q000378:metabolism; D006801:Humans; D053858:Metabolic Networks and Pathways; D057093:Orphan Nuclear Receptors / Q000378:metabolism; D047492:Peroxisome Proliferator-Activated Receptors / Q000378:metabolism; D019936:Probiotics / Q000378:metabolism; D018167:Receptors, Calcitriol / Q000378:metabolism; D018160:Receptors, Cytoplasmic and Nuclear / Q000378:metabolism*; D011987:Receptors, Steroid / Q000378:metabolism; D013261:Sterols / Q000378:metabolism
chemical_list: D004224:Diterpenes; D005419:Flavonoids; D057093:Orphan Nuclear Receptors; D047492:Peroxisome Proliferator-Activated Receptors; D018167:Receptors, Calcitriol; D018160:Receptors, Cytoplasmic and Nuclear; D011987:Receptors, Steroid; D013261:Sterols; C053400:cafestol; D003474:Curcumin