Treatment of a large postextraction buccal wall defect with mineralized allograft, β-TCP, and rhPDGF-BB: a growth factor-mediated bone regenerative approach.
Buccal wall defects following tooth removal are frequent in the anterior portions of the mandible and maxilla. Common reasons for such defects include thin buccal bone, preexisting periodontal disease, bundle bone resorption, difficult orthodontic movement, and traumatic extractions. Regeneration of the postextraction defect with vital, well-vascularized, dense bone is critical to a successful implant-supported restoration. This case report examines the effectiveness of using a composite graft of freeze-dried bone allograft and β-tricalcium phosphate plus recombinant human platelet-derived growth factor BB to regenerate healthy, dense bone in a large mandibular anterior buccal wall defect. The importance of access to the overlying periosteum as a readily available source of osteogenic cells in growth factor-mediated bone regenerative procedures is emphasized.
Department of Periodontics, University of Pennsylvania School of Dental Medicine, Philadelphia, Pennsylvania, USA. msnyder@osteohealth.com
Mark B
MB
Snyder
D016301:Alveolar Bone Loss / Q000601:surgery*; D043925:Angiogenesis Inducing Agents / Q000627:therapeutic use*; D000077214:Becaplermin; D015519:Bone Density / Q000502:physiology; D001861:Bone Regeneration / Q000502:physiology; D018786:Bone Substitutes / Q000627:therapeutic use*; D016025:Bone Transplantation / Q000379:methods*; D002130:Calcium Phosphates / Q000627:therapeutic use*; D003481:Cuspid / Q000473:pathology; D003758:Dental Implantation, Endosseous / Q000379:methods; D015921:Dental Implants; D005260:Female; D005500:Follow-Up Studies; D016557:Guided Tissue Regeneration, Periodontal / Q000379:methods; D006801:Humans; D008334:Mandible / Q000601:surgery*; D008875:Middle Aged; D010012:Osteogenesis / Q000502:physiology; D020574:Proto-Oncogene Proteins c-sis / Q000627:therapeutic use*; D011994:Recombinant Proteins; D012391:Root Resorption / Q000601:surgery; D014081:Tooth Extraction; D020390:Tooth Socket / Q000601:surgery*
D043925:Angiogenesis Inducing Agents; D018786:Bone Substitutes; D002130:Calcium Phosphates; D015921:Dental Implants; D020574:Proto-Oncogene Proteins c-sis; D011994:Recombinant Proteins; C485817:beta-tricalcium phosphate; D000077214:Becaplermin