Dissociation and convergence of the dorsal and ventral visual working memory streams in the human prefrontal cortex.
Visual information is largely processed through two pathways in the primate brain: an object pathway from the primary visual cortex to the temporal cortex (ventral stream) and a spatial pathway to the parietal cortex (dorsal stream). Whether and to what extent dissociation exists in the human prefrontal cortex (PFC) has long been debated. We examined anatomical connections from functionally defined areas in the temporal and parietal cortices to the PFC, using noninvasive functional and diffusion-weighted magnetic resonance imaging. The right inferior frontal gyrus (IFG) received converging input from both streams, while the right superior frontal gyrus received input only from the dorsal stream. Interstream functional connectivity to the IFG was dynamically recruited only when both object and spatial information were processed. These results suggest that the human PFC receives dissociated and converging visual pathways, and that the right IFG region serves as an integrator of the two types of information.
Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Athinoula A Martinos Center for Biomedical Imaging, Charlestown, MA 02129, USA. emi@nmr.mgh.harvard.edu
Emi
E
Takahashi
Kenichi
K
Ohki
Dae-Shik
DS
Kim
D000328:Adult; D001931:Brain Mapping; D038524:Diffusion Magnetic Resonance Imaging; D005260:Female; D006801:Humans; D007090:Image Interpretation, Computer-Assisted; D008279:Magnetic Resonance Imaging; D008297:Male; D008570:Memory, Short-Term / Q000502:physiology*; D017397:Prefrontal Cortex / Q000502:physiology*; D014795:Visual Pathways / Q000502:physiology*; D055815:Young Adult