Elevated urinary NT-proBNP after pharmacological closure of patent ductus arteriosus in very low birth weight infants.
BACKGROUND
Hemodynamically significant patent ductus arteriosus (hsPDA) complicates the clinical course of preterm infants and contributes to increased morbidity and mortality. NT-proBNP is indicative of the effects of hsPDA on clinical and cardiac status of patients.


OBJECTIVE
The aim of this study was to evaluate the value of urinary NT-proBNP and NT-proBNP/creatinine ratio in follow-up of hsPDA.


METHODS
Urinary NT-proBNP and NT-proBNP/creatinine ratio (UNBCR) were measured and correlated with the presence of hsPDA. Measurements were performed in 92 neonates on postnatal days 14 and 28 by ELISA methodology. Of 92 neonates, 22 required therapeutic interventions.


RESULTS
Infants treated for hsPDA showed significant higher levels of urinary NT-proBNP and UNBCR on postnatal day 14 whereas similar results were determined on postnatal day 28. Cut-off level of NT-proBNP was 567pg/mL with a sensitivity of 79% and a specificity of 71%.


CONCLUSIONS
Our data showed that NT-proBNP and UNBCR levels as non-invasive and powerful methods in preterm infants may help clinicians to determine the effects of hsPDA on clinical and cardiac status of the patients even with first measurement on day 14.
Division of Neonatology, Mersin Maternity and Child Health Hospital, Mersin, Turkey. istemihancelik@gmail.com
Istemi Han
IH
Celik
Omer
O
Erdeve
Gamze
G
Demırel
Fuat Emre
FE
Canpolat
Ugur
U
Dilmen
D015415:Biomarkers / Q000652:urine*; D003401:Creatine / Q000652:urine; D004374:Ductus Arteriosus, Patent / Q000188:drug therapy* / Q000652:urine; D015150:Echocardiography, Doppler; D004797:Enzyme-Linked Immunosorbent Assay; D006801:Humans; D007052:Ibuprofen / Q000378:metabolism / Q000627:therapeutic use*; D007231:Infant, Newborn; D019102:Infant, Very Low Birth Weight; D020097:Natriuretic Peptide, Brain / Q000652:urine*; D010446:Peptide Fragments / Q000652:urine*; D011446:Prospective Studies; D012372:ROC Curve; D018709:Statistics, Nonparametric; D014421:Turkey
D015415:Biomarkers; D010446:Peptide Fragments; C109794:pro-brain natriuretic peptide (1-76); D020097:Natriuretic Peptide, Brain; D003401:Creatine; D007052:Ibuprofen