Rangelia vitalii: changes in the enzymes ALT, CK and AST during the acute phase of experimental infection in dogs.
Rangelia vitalii is a protozoon that causes diseases in dogs, and anemia is the most common laboratory finding. However, few studies on the biochemical changes in dogs infected with this protozoon exist. Thus, this study aimed to investigate the biochemical changes in dogs experimentally infected with R. vitalii, during the acute phase of the infection. For this study, 12 female dogs (aged 6-12 months and weighing between 4 and 7 kg) were used, divided in two groups. Group A was composed of healthy dogs (n = 5); and group B consisted of infected animals (n = 7). Blood samples were collected on days 0, 10, 20 and 30 after infection, using tubes without anticoagulant to obtain serum and analyze the biochemical parameters. An increase in alanine aminotransferase (ALT) on day 20 (P < 0.05) was observed. Also, increased creatine kinase (CK) and aspartate aminotransferase (AST) levels were observed throughout the experimental period (P < 0.05). No changes in the serum gamma-glutamyltransferase, urea and creatinine levels were observed. Thus, is possible to conclude that experimental infection with R. vitalii in dogs causes changes to the biochemical profile, with increased ALT, AST and CK enzyme levels.
Department of Small Animals, Federal University of Santa Maria, Santa Maria, RS, Brazil. marmcvet@yahoo.com.br
Márcio Machado
MM
Costa
Raqueli Teresinha
RT
França
Aleksandro Schafer
AS
Da Silva
Carlos Breno
CB
Paim
Francine
F
Paim
Carlos Henrique
CH
do Amaral
Guilherme Lopes
GL
Dornelles
João Paulo Monteiro Carvalho Mori
JP
da Cunha
João Fabio
JF
Soares
Marcelo Bahia
MB
Labruna
Cinthia Melazzo Andrade
CM
Mazzanti
Silvia Gonzalez
SG
Monteiro
Sonia Terezinha Dos Anjos
ST
Lopes
D000208:Acute Disease; D000410:Alanine Transaminase / Q000097:blood*; D000818:Animals; D001219:Aspartate Aminotransferases / Q000097:blood*; D003402:Creatine Kinase / Q000097:blood*; D004283:Dog Diseases / Q000097:blood* / Q000201:enzymology / Q000469:parasitology*; D004285:Dogs; D005260:Female; D011529:Protozoan Infections, Animal / Q000097:blood* / Q000201:enzymology
D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase; D003402:Creatine Kinase