Are the anti-arrhythmic effects of omega-3 fatty acids due to modulation of myocardial calcium handling?
Both animal and clinical studies have demonstrated that omega-3 fatty acids have anti-arrhythmic properties. It has been suggested that these anti-arrhythmic effects are due to modulation of the activity of various myocardial calcium handling proteins such as ryanodine receptor (RyR), L-type calcium current and sodium/calcium exchanger. In this article, we review all the data available on the effects of omega-3 fatty acids on ventricular myocardial calcium handling. In addition we highlight some unanswered questions and discuss possible therapeutic benefits of omega-3 fatty acids.
Cardiovascular Research Group, University of Manchester Manchester, UK ; Manchester Royal Infirmary, Manchester Heart Centre Manchester, UK.
Rajiv
R
Sankaranarayanan
Luigi
L
Venetucci