[Proton pump inhibitors in gastro-oesophageal reflux disease: what is the further step?].
Optimisation of proton pump inhibitors use may improve reflux symptoms in 20-25% of the patients. Pathological gastro-oesophageal reflux should be documented in a patient with refractory reflux symptoms using upper endoscopy and/or pH testing. While on proton pump inhibitors twice daily, persistent symptoms are not related to gastro-oesophageal refluxdisease(GERD) in 50% of the patients. The new anti-reflux compounds have yet a limited efficacy and side effects that currently limit their development.
Université Bordeaux Segalen, CHU de Bordeaux, hôpital Saint-André, service hépatogastro-entérologie et oncologie digestive, 33075 Bordeaux, France.
Mireille
M
Simon
Frank
F
Zerbib
D019468:Disease Management; D005764:Gastroesophageal Reflux / Q000175:diagnosis / Q000188:drug therapy*; D006801:Humans; D054328:Proton Pump Inhibitors / Q000627:therapeutic use*; D017494:Proton Pumps / Q000187:drug effects*
D054328:Proton Pump Inhibitors; D017494:Proton Pumps