Plasmid-templated shape control of condensed DNA-block copolymer nanoparticles.
DNA-containing micellar nanoparticles with distinctly different and highly uniform morphologies are prepared via condensation of plasmid DNA with a block copolymer of polyethylene glycol and a polycation in solvents of different polarity. Molecular dynamics simulations explain the underlying mechanism.
Department of Materials Science and Engineering, Whiting School of Engineering, Johns Hopkins University, Baltimore, Maryland 21218, USA.
Xuan
X
Jiang
Wei
W
Qu
Deng
D
Pan
Yong
Y
Ren
John-Michael
JM
Williford
Honggang
H
Cui
Erik
E
Luijten
Hai-Quan
HQ
Mao
D000577:Amides / Q000737:chemistry; D004247:DNA / Q000737:chemistry*; D004126:Dimethylformamide / Q000737:chemistry; D008823:Micelles; D053758:Nanoparticles / Q000737:chemistry*; D010756:Phosphoric Acids / Q000737:chemistry; D010957:Plasmids / Q000737:chemistry*; D011092:Polyethylene Glycols / Q000737:chemistry; D011108:Polymers / Q000737:chemistry*; D014867:Water / Q000737:chemistry
D000577:Amides; D008823:Micelles; D010756:Phosphoric Acids; D011108:Polymers; D014867:Water; D011092:Polyethylene Glycols; D004126:Dimethylformamide; D004247:DNA; C011067:phosphoramidic acid