Cristaxenicin A, an antiprotozoal xenicane diterpenoid from the deep sea gorgonian Acanthoprimnoa cristata.
A new xenicane diterpenoid, cristaxenicin A (1), has been isolated from the deep sea gorgonian Acanthoprimnoa cristata. The structure of 1 was elucidated on the basis of spectral analysis including NMR and MS. The absolute configuration of 1 was determined on the basis of quantum chemical calculation of CD spectra. Cristaxenicin A (1) showed antiprotozoal activities against Leishmania amazonensis and Trypanosoma congolense with IC(50) values of 0.088 and 0.25 μM, respectively.
Graduate School of Advanced Science and Engineering, Waseda University, 3-4-1 Okubo, Shinjuku-ku, Tokyo, 169-8555, Japan.
Shin-Taro
ST
Ishigami
Yasuyuki
Y
Goto
Noboru
N
Inoue
Shin-Ichiro
S
Kawazu
Yoshitsugu
Y
Matsumoto
Yukimitsu
Y
Imahara
Moto
M
Tarumi
Hiromi
H
Nakai
Nobuhiro
N
Fusetani
Yoichi
Y
Nakao
D000818:Animals; D037421:Anthozoa / Q000737:chemistry*; D000981:Antiprotozoal Agents / Q000737:chemistry* / Q000494:pharmacology*; D004224:Diterpenes / Q000737:chemistry* / Q000494:pharmacology; D020128:Inhibitory Concentration 50; D007891:Leishmania / Q000737:chemistry* / Q000187:drug effects*; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure
D000981:Antiprotozoal Agents; D004224:Diterpenes; C581652:cristaxenicin A