Association of HLA locus variant in Parkinson's disease.
A variant (rs3129882) in the genome-wide association study (GWAS)-linked variant [in the human leukocyte antigen (HLA) gene region] has been reported to associate with an increased risk of Parkinson's disease (PD) in Caucasian population. Studies among Chinese are limited. To address this, we analysed rs3129882 in a total of 1312 subjects of Chinese ethnicity from independent Asian centers comprising of 675 controls and 637 PD cases. The rs3129882 variant was associated with a decreased risk in our ethnic Chinese PD patients. Logistic regression analysis taking into consideration variables of age, gender and race showed that allele A reduced the risk of PD via a dominant model [odds ratio (OR) = 0.77, 95% confidence interval (CI) = 0.62, 0.96, p = 0.018]. As HLA is a highly polymorphic region, it is possible that ethnic-specific effect or environmental agents may modulate the effect of this GWAS-linked locus in influencing the risk of PD.
Department of Neurology; Department of Clinical Research, Singapore General Hospital, National Neuroscience Institute, Singapore, Singapore.
Y
Y
Zhao
A A
AA
Gopalai
A
A
Ahmad-Annuar
E W L
EW
Teng
K M
KM
Prakash
L C S
LC
Tan
W-L
WL
Au
H-H
HH
Li
S-Y
SY
Lim
S K
SK
Lim
Y B
YB
Chong
L P
LP
Tan
N M
NM
Ibrahim
E-K
EK
Tan
D000368:Aged; D044466:Asian People; D016022:Case-Control Studies; D005260:Female; D056726:Genetic Association Studies; D056426:Genetic Loci; D059805:HLA-DR alpha-Chains / Q000235:genetics*; D006801:Humans; D007113:Immunity, Innate / Q000235:genetics*; D007249:Inflammation / Q000208:ethnology / Q000235:genetics; D008297:Male; D008875:Middle Aged; D010300:Parkinson Disease / Q000208:ethnology / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide
D059805:HLA-DR alpha-Chains