Solid state grinding as a tool to aid enantiomeric resolution by cocrystallisation.
The formation of diastereomeric cocrystals of malic acid and tartaric acid was investigated by liquid-assisted grinding in the solid state. We demonstrate that racemic malic acid can be converted into two distinct diastereomeric cocrystal phases by grinding with a single enantiomer of tartaric acid.
Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW, UK.
Mark D
MD
Eddleston
Mihails
M
Arhangelskis
Tomislav
T
Friščić
William
W
Jones
D003460:Crystallization; D018360:Crystallography, X-Ray; D008293:Malates / Q000737:chemistry*; D008968:Molecular Conformation; D013237:Stereoisomerism; D013644:Tartrates / Q000737:chemistry*
D008293:Malates; D013644:Tartrates; C030298:malic acid; C029768:tartaric acid