Ethnic and racial disparities in the risk of preterm birth: a systematic review and meta-analysis.
OBJECTIVE
The aim of this study is to present a systematic review of available literature on the effect of maternal ethnicity (Africans/blacks, Asians, Hispanics, others) on the risk of preterm birth (PTB).


METHODS
Studies investigating ethnicity (or race) as a risk factor for PTB were included if performing adjustments for confounders. A meta-analysis was performed, and data were synthesized using a random effects model.


RESULTS
Forty-five studies met the inclusion criteria. Black ethnicity was associated with an increased risk of PTB when compared with whites (range of adjusted odds ratios [ORs] 0.6 to 2.8, pooled OR 2.0; 95% confidence interval [CI] 1.8 to 2.2). For Asian ethnicity, there was no significant association (range of adjusted ORs 0.6 to 2.3). For Hispanic ethnicity, there also was no significant association (range of adjusted ORs 0.7 to 1.5).


CONCLUSIONS
Ethnic disparities in the risk of PTB were clearly pronounced among black women. Future research should focus on preventative strategies for ethnic groups at high risk for PTB. Information on ethnic disparities in risk of PTB-related neonatal morbidity and mortality is lacking and is also a topic of interest for future research.
Department of Medical Informatics, Academic Medical Centre, Amsterdam, The Netherlands. j.m.schaaf@amc.uva.nl
Jelle M
JM
Schaaf
Sophie M S
SM
Liem
Ben Willem J
BW
Mol
Ameen
A
Abu-Hanna
Anita C J
AC
Ravelli
D015986:Confounding Factors, Epidemiologic; D005260:Female; D005865:Gestational Age; D054624:Health Status Disparities; D006801:Humans; D017533:Marital Status; D008423:Maternal Age; D010298:Parity; D011247:Pregnancy; D047928:Premature Birth / Q000208:ethnology*; D012307:Risk Factors; D012923:Social Class