Migraine with aura associated with unilateral cortical increase in vascular permeability.
BACKGROUND
Few studies to date have captured perfusion and vascular permeability changes during a migraineur's aura. This may be important information to the clinician in the context of the differential diagnosis of migraine with aura versus acute stroke.


CONCLUSIONS
We report a case in which magnetic resonance perfusion during a migraine aura showed unilateral hypoperfusion differentially affecting gray and white matter and was associated with a hemispheric increase in permeability.


CONCLUSIONS
Imaging in this case suggests that migraine aura is associated with oligemia below the threshold for infarction. Increased vascular permeability may be a critical mechanism contributing to perfusion changes observed in migraine with aura.
Division of Neurology, Department of Medicine, Sunnybrook Health Sciences Centre, University of Toronto, Canada.
D L
DL
Rotstein
R I
RI
Aviv
B J
BJ
Murray
D000208:Acute Disease; D000293:Adolescent; D001037:Aphasia / Q000209:etiology* / Q000503:physiopathology; D002199:Capillary Permeability / Q000502:physiology*; D002540:Cerebral Cortex / Q000098:blood supply* / Q000503:physiopathology; D002561:Cerebrovascular Disorders / Q000150:complications* / Q000503:physiopathology; D007839:Functional Laterality / Q000502:physiology; D006801:Humans; D018810:Magnetic Resonance Angiography; D008297:Male; D020325:Migraine with Aura / Q000209:etiology* / Q000503:physiopathology