Effects of cationic hydroxyethyl cellulose on dyslipidemia in hamsters.
Cationic hydroxyethyl cellulose (cHEC) was supplemented in a high-fat diet to determine if this new soluble fiber had an effect on hypercholesterolemia and dyslipidemia associated with cardiovascular disease using Golden Syrian hamster as an animal model. Supplementation of 3-5% cHEC in a high-fat diet for 4 weeks led to significant weight gain reduction in hamsters. In addition, significant decreases in adipose and liver weights, concentrations of plasma total, VLDL, and LDL cholesterol, and hepatic lipids were shown. No significant improvements in glucose and insulin levels were observed with cHEC; however, a significant increase in plasma adiponectin and a decrease in leptin were observed. As compared with controls, 8% cHEC-fed hamsters had greater levels of mRNA for CYP7A1 (cytochrome P450 7A1; 2-fold of control; P < 0.05), CYP51 (lanosterol 14α-demethylase; 6-fold of control; P < 0.05), and LDLR (LDL receptor; 1.5-fold of control) in the liver. These findings suggest the possibility of the use of cHEC for cholesterol reduction and beneficial effects on the cardiovascular risk factors.
The Dow Chemical Company, Midland, Michigan 48667, USA.
Shao-Ching
SC
Hung
Wallace
W
Yokoyama
Hyunsook
H
Kim
Glenn
G
Bartley
William H K
WH
Anderson
David R
DR
Albers
Marsha L
ML
Langhorst
David M
DM
Williams
William
W
Stott
Maciej
M
Turowski
Scott A
SA
Young
D000818:Animals; D015415:Biomarkers / Q000097:blood; D001786:Blood Glucose / Q000032:analysis; D002412:Cations; D002482:Cellulose / Q000031:analogs & derivatives* / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use; D002790:Cholesterol 7-alpha-Hydroxylase / Q000235:genetics; D006224:Cricetinae; D050171:Dyslipidemias / Q000188:drug therapy*; D007328:Insulin / Q000097:blood; D008055:Lipids / Q000097:blood; D008647:Mesocricetus; D009929:Organ Size / Q000187:drug effects; D012333:RNA, Messenger / Q000235:genetics; D060888:Real-Time Polymerase Chain Reaction
D015415:Biomarkers; D001786:Blood Glucose; D002412:Cations; D007328:Insulin; D008055:Lipids; D012333:RNA, Messenger; D002482:Cellulose; C002283:hydroxyethylcellulose; D002790:Cholesterol 7-alpha-Hydroxylase