Brain-derived neurotrophic factor in the nucleus tractus solitarii modulates glucose homeostasis after carotid chemoreceptor stimulation in rats.
Neuronal systems, which regulate energy intake, energy expenditure and endogenous glucose production, sense and respond to input from hormonal related signals that convey information from body energy availability. Carotid chemoreceptors (CChr) function as sensors for circulating glucose levels and contribute to glycemic counterregulatory responses. Brain-derived neurotrophic factor (BDNF) that plays an important role in the endocrine system to regulate glucose metabolism could play a role in hyperglycemic glucose reflex with brain glucose retention (BGR) evoked by anoxic CChr stimulation. Infusing BDNF into the nucleus tractus solitarii (NTS) before CChr stimulation, showed that this neurotrophin increased arterial glucose and BGR. In contrast, BDNF receptor (TrkB) antagonist (K252a) infusions in NTS resulted in a decrease in both glucose variables.
Universidad de Colima, Colima, Mexico.
Sergio
S
Montero
Ricardo
R
Cuéllar
Mónica
M
Lemus
Reyes
R
Avalos
Gladys
G
Ramírez
Elena Roces
ER
de Álvarez-Buylla
D000818:Animals; D001786:Blood Glucose / Q000032:analysis*; D019208:Brain-Derived Neurotrophic Factor / Q000502:physiology*; D002344:Carotid Body / Q000502:physiology*; D006706:Homeostasis; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D012966:Sodium Cyanide / Q000494:pharmacology; D017552:Solitary Nucleus / Q000502:physiology*
D001786:Blood Glucose; D019208:Brain-Derived Neurotrophic Factor; D012966:Sodium Cyanide