[An association between microalbuminuria and obesity in healthy adolescents - preliminary results from the "Respect for Health" study].
BACKGROUND
Microalbuminuria is a marker of present/future cardiovascular and/or renal disease. The roots of these diseases extend back into childhood. Data on renal excretion of albumin (albumin/creatinine ratio - ACR) and the prevalence of microalbuminuria in apparently healthy adolescents are scares.


RESULTS
We determined ACR and the prevalence of microalbuminuria in 15-to-19-years-old adolescents (n = 846, 482 boys), in association with markers of obesity. ACR (0.43; 0.29-0.67 mg albumin/mmol creatinine vs 0.35; 0.25-0.51 mg albumin/mmol creatinine, p < 0.001), and the prevalence of microalbuminuria (3.6 % vs 1.2 %, χ2: p = 0.024) were higher in girls than in boys. In underweight subjects, particularly boys, ACR was significantly higher if compared with the overweight//obese subjects. ACR correlated inversely with the markers of peripheral and central obesity.


CONCLUSIONS
Prevalence of microalbuminuria in general population of adolescents was relatively low. Paradoxically, in the boys ACR showed an inverse relationship to markers of nutritional status. Our data suggest the need of specific interpretation of data on ACR in the adolescents, and the need of further analysis of this (in the adults risk) marker in population of adolescents with regard to other important determinants of ACR, such as actual blood pressure, insulin sensitivity, etc.
Ustav molekularnej biomediciny Lekarskej fakulty UK, Bratislava, Slovenska republika. kata.sebekova@gmail.com
K
K
Sebeková
R
R
Kollárová
A
A
Stecová
V
V
Potičný
Z
Z
Gerová
D000293:Adolescent; D000419:Albuminuria / Q000150:complications*; D000886:Anthropometry; D015992:Body Mass Index; D003404:Creatinine / Q000652:urine*; D005260:Female; D006801:Humans; D008297:Male; D009765:Obesity / Q000473:pathology / Q000652:urine*
D003404:Creatinine