[Toxoplasma infection, a rare but life-threatening complication after kidney transplantation: report of two cases].
Toxoplasma infection is uncommon after renal transplantation. As a result, Toxoplasma gondii is often missed from the list of microbial agents which may be responsible of an infectious complication after renal transplantation. However, establishing this diagnosis is very important because toxoplasmosis can be life-threatening in an immunocompromised host, particularly when the diagnosis is too delayed. Here we report two cases of severe toxoplasmosis after renal transplantation. In the first case, primary infection transmitted by a cat developed in a seronegative recipient five years after renal transplantation. In the second case, reactivation of latent infection developed in a seropositive recipient 9 months after transplantation. In both cases, systematic screening for Toxoplasma gondii using polymerase chain reaction (PCR) in biological fluids was essential to suggest the diagnosis. Both recipients rapidly recovered after institution of antiparasitic therapy.
Service de néphrologie et transplantation rénale, hôpital Lapeyronie, université de Montpellier, CHU de Montpellier, 34295 Montpellier 05, France.
Sébastien
S
Jugant
Service de néphrologie et transplantation rénale, hôpital Lapeyronie, université de Montpellier, CHU de Montpellier, 34295 Montpellier 05, France.
Vincent
V
Pernin
Service de néphrologie et transplantation rénale, hôpital Lapeyronie, université de Montpellier, CHU de Montpellier, 34295 Montpellier 05, France.
Fernando
F
Vetromile
Service de néphrologie et transplantation rénale, hôpital Lapeyronie, université de Montpellier, CHU de Montpellier, 34295 Montpellier 05, France.
Valérie
V
Garrigue
Service de néphrologie et transplantation rénale, hôpital Lapeyronie, université de Montpellier, CHU de Montpellier, 34295 Montpellier 05, France.
Sylvie
S
Delmas
Service de néphrologie et transplantation rénale, hôpital Lapeyronie, université de Montpellier, CHU de Montpellier, 34295 Montpellier 05, France.
Ilan
I
Szwarc
Laboratoire de parasitologie, CHU de Montpellier, 34295 Montpellier 05, France.
Yvon
Y
Sterkers
Service de néphrologie et transplantation rénale, hôpital Lapeyronie, université de Montpellier, CHU de Montpellier, 34295 Montpellier 05, France. Electronic address: g-mourad@chu-montpellier.fr.
Georges
G
Mourad
D000368:Aged; D006801:Humans; D016030:Kidney Transplantation; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications / Q000175:diagnosis / Q000188:drug therapy; D012720:Severity of Illness Index; D014123:Toxoplasmosis / Q000175:diagnosis / Q000188:drug therapy