Mesenchymoproliferative enteropathy associated with dual simian polyomavirus and rhesus cytomegalovirus infection in a simian immunodeficiency virus-infected rhesus macaque (Macaca mulatta).
Opportunistic viral infections are common in simian immunodeficiency virus-infected rhesus macaques and include simian polyomavirus 40 (SV40), which causes interstitial nephritis, pneumonia, meningoencephalitis, and progressive multifocal leukoencephalopathy and rhesus cytomegalovirus (Macacine herpesvirus-3), which is associated with many pathologic manifestations, including the formation of neutrophil-rich gastrointestinal masses. Herein we report the findings of a simian immunodeficiency virus-infected rhesus macaque that presented to necropsy with multiple nodular masses restricted to the proximal jejunum. Histologically, the masses within the lamina propria were composed of abundant, loosely organized, mesenchymal tissue forming broad interlacing whorls and sheets admixed with variable numbers of neutrophils. Cells within the mesenchymoproliferative nodules contained numerous basophilic, intranuclear inclusion bodies with only scattered cytomegalic cells. Immunohistochemistry for rhesus cytomegalovirus and SV40 demonstrated variable numbers of immunopositive cells within the affected nodules. This report is the first description of SV40-associated pathology in the small intestine of a rhesus macaque and highlights the role that opportunistic viral infections can have on gastrointestinal pathology in immunosuppressed rhesus macaques.
Harvard Medical School, New England Primate Research Center, One Pine Hill Drive, Southborough, MA 01772, USA. Sheila_macri@hms.harvard.edu
S
S
Cummings Macri
H L
HL
Knight
A D
AD
Miller
D000818:Animals; D049109:Cell Proliferation; D003587:Cytomegalovirus / Q000302:isolation & purification; D003586:Cytomegalovirus Infections / Q000150:complications / Q000473:pathology / Q000662:veterinary* / Q000821:virology; D016867:Immunocompromised Host; D007150:Immunohistochemistry; D007421:Intestine, Small / Q000473:pathology / Q000821:virology; D007583:Jejunum / Q000473:pathology / Q000821:virology; D008253:Macaca mulatta; D008648:Mesoderm / Q000473:pathology / Q000821:virology; D008992:Monkey Diseases / Q000473:pathology* / Q000821:virology; D009092:Mucous Membrane / Q000473:pathology / Q000821:virology; D009894:Opportunistic Infections / Q000150:complications / Q000473:pathology / Q000662:veterinary / Q000821:virology; D027601:Polyomavirus Infections / Q000150:complications / Q000473:pathology / Q000662:veterinary* / Q000821:virology; D016097:Simian Acquired Immunodeficiency Syndrome / Q000150:complications / Q000473:pathology / Q000821:virology; D015302:Simian Immunodeficiency Virus / Q000502:physiology; D013539:Simian virus 40 / Q000302:isolation & purification*; D014412:Tumor Virus Infections / Q000150:complications / Q000473:pathology / Q000662:veterinary* / Q000821:virology