[Therapeutic approach in a case of allergic reaction to antituberculosis drugs -- a case report].
Medicaton used to treat tuberculosis is responsible for numerous side effects that have a major impact on patient's health, with a negative influence on the quality of life. Patients of all ages must be trained in order to recognize all the adverse effects and the undesirable reactions produced by antituberculosis medication. We report the case of a 24-year-old woman with generalized psoriasis and psoriatic arthropathy who was treated against tuberculosis. After 7 days of treatment with isoniazid, rifampicin, ethambutol and pyrazinamid she had severe allergic reaction with generalized pruritus and rash which were difficult to control with antiallergic treatment.


CONCLUSIONS
Particular to this case is the absence in patient's history of the allergic reactions to medication. The re-establishment of treatment of tuberculosis was done by clinical trials and the patient had responded to only three drugs: isoniazid, rifampicin and ofloxacin, so the patient received an individual treatment due to adverse reactions to tuberculosis medications.
Facultatea de Farmacie, Universităţii de Medicină şi Farmacie "Grigore T. Popa"--Iaşi.
Magda
M
Costin
A
A
Tesloianu
T
T
Mihăescu
Elena
E
Butnaru
D000328:Adult; D000995:Antitubercular Agents / Q000008:administration & dosage* / Q000009:adverse effects*; D015535:Arthritis, Psoriatic / Q000150:complications; D003888:Desensitization, Immunologic / Q000379:methods*; D003875:Drug Eruptions / Q000209:etiology; D004977:Ethambutol / Q000008:administration & dosage / Q000009:adverse effects; D005260:Female; D006801:Humans; D006967:Hypersensitivity / Q000209:etiology*; D007538:Isoniazid / Q000008:administration & dosage / Q000009:adverse effects; D015242:Ofloxacin / Q000008:administration & dosage / Q000009:adverse effects; D011565:Psoriasis / Q000150:complications*; D011718:Pyrazinamide / Q000008:administration & dosage / Q000009:adverse effects; D012293:Rifampin / Q000008:administration & dosage / Q000009:adverse effects; D016896:Treatment Outcome; D014397:Tuberculosis, Pulmonary / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy* / Q000601:surgery
D000995:Antitubercular Agents; D011718:Pyrazinamide; D004977:Ethambutol; D015242:Ofloxacin; D007538:Isoniazid; D012293:Rifampin