Human skin hypoxia modulates cerebrovascular and autonomic functions.
Because the skin is an oxygen sensor in amphibians and mice, we thought to confirm this function also in humans. The human upright posture, however, introduces additional functional demands for the maintenance of oxygen homeostasis in which cerebral blood flow and autonomic nervous system (ANS) function may also be involved. We examined nine males and three females. While subjects were breathing ambient air, at sea level, we changed gases in a plastic body-bag during two conditions of the experiment such as to induce skin hypoxia (with pure nitrogen) or skin normoxia (with air). The subjects performed a test of hypoxic ventilatory drive during each condition of the experiment. We found no differences in the hypoxic ventilatory drive tests. However, ANS function and cerebral blood flow velocities were modulated by skin hypoxia and the effect was significantly greater on the left than right middle cerebral arteries. We conclude that skin hypoxia modulates ANS function and cerebral blood flow velocities and this might impact life styles and tolerance to ambient hypoxia at altitude. Thus the skin in normal humans, in addition to its numerous other functions, is also an oxygen sensor.
Department of Anesthesiology, University of Toronto, Ontario, Canada.
Olivia
O
Pucci
Clifford
C
Qualls
Anne
A
Battisti-Charbonney
Dahlia Y
DY
Balaban
Joe A
JA
Fisher
Jim
J
Duffin
Otto
O
Appenzeller
D000328:Adult; D001341:Autonomic Nervous System / Q000502:physiology*; D002560:Cerebrovascular Circulation / Q000502:physiology*; D005260:Female; D006801:Humans; D000860:Hypoxia / Q000503:physiopathology*; D008297:Male; D020768:Middle Cerebral Artery / Q000502:physiology; D012867:Skin / Q000378:metabolism* / Q000503:physiopathology*; D055815:Young Adult