Real-time pathology to guide breast surgery: seeing alone is not believing.
Tissue diagnostic techniques based on optical spectroscopy, in various incarnations, are approaching clinical reality for intraoperative guidance of surgical procedures. Examination of tissue properties by elastic light-scattering spectroscopy may constitute a preferable alternative to frozen-section pathology or touch imprint cytology for intraoperative assessment of resection margins during breast-conserving surgery.
Department of Biomedical Engineering, Electrical & Computer Engineering, and Medicine, Boston University, Boston, Massachusetts 02215, USA. bigio@bu.edu
Irving J
IJ
Bigio
D001943:Breast Neoplasms / Q000175:diagnosis*; D002285:Carcinoma, Intraductal, Noninfiltrating / Q000175:diagnosis*; D005260:Female; D006801:Humans; D013057:Spectrum Analysis / Q000295:instrumentation*