Commentary: How the debate about comparative effectiveness research should impact the future of clinical trials.
Comparative effectiveness research represents the kind of research that arguably more directly affects clinical practice and policy. It includes observational studies, clinical trials, and systematic syntheses of existing literature. In this commentary, I argue for the ongoing and critical role of randomization in comparative effectiveness, noting the key differences between practical and explanatory trials.
Division of Cardiovascular Sciences, National Heart, Lung, and Blood Institute, Bethesda, MD, USA. lauerm@nhlbi.nih.gov
Michael S
MS
Lauer
D057186:Comparative Effectiveness Research / Q000458:organization & administration*; D016032:Randomized Controlled Trials as Topic / Q000592:standards*