Association of GSTM1 null allele with prostate cancer risk: evidence from 36 case-control studies.
BACKGROUND
Glutathione S-transferase M1 (GSTM1) is thought to be involved in detoxifying several carcinogens and may play a vital role in tumorigenesis. Numerous studies have evaluated the association between GSTM1 null/present polymorphism and risk of prostate cancer (PCa). However, the results remain inconsistent. To derive a more precise estimation, we performed a meta-analysis.


RESULTS
A comprehensive search was conducted to identify all eligible case-control studies. We used odds ratios (ORs) with 95% confidence intervals (CIs) to assess the strength of the association. The overall association was significant (OR = 1.28, 95% CI: 1.11-1.48, P = 0.001). Moreover, subgroup analyses showed GSTM1 null genotype significantly associated with PCa risk among Asians (OR = 1.35, 95% CI: 1.03-1.78, P = 0.03) but not among Caucasians (OR = 1.12, 95% CI: 0.96-1.31, P = 0.16). In addition, we did not find that smoking modified the genotype effect on the risk of PCa.


CONCLUSIONS
The present meta-analysis suggested that GSTM1 null allele was a low-penetrant risk factor for PCa among Asians.
Department of Urology, Affiliated Wuxi People's Hospital, Nanjing Medical University, Wuxi, China.
Bingbing
B
Wei
Zhuoqun
Z
Xu
You
Y
Zhou
Jun
J
Ruan
Huan
H
Cheng
Bo
B
Xi
Ming
M
Zhu
Ke
K
Jin
Deqi
D
Zhou
Qiang
Q
Hu
Qiang
Q
Wang
Zhirong
Z
Wang
Zhiqiang
Z
Yan
Feng
F
Xuan
Xing
X
Huang
Jian
J
Zhang
Hongyi
H
Zhou
D000483:Alleles; D044466:Asian People / Q000235:genetics; D016022:Case-Control Studies; D020022:Genetic Predisposition to Disease; D005982:Glutathione Transferase / Q000235:genetics*; D006801:Humans; D008297:Male; D016017:Odds Ratio; D011110:Polymorphism, Genetic; D011471:Prostatic Neoplasms / Q000235:genetics*; D012907:Smoking / Q000235:genetics; D044465:White People / Q000235:genetics
D005982:Glutathione Transferase