Complementary enantiorecognition patterns and specific method optimization aspects on immobilized polysaccharide-derived chiral stationary phases.
The immobilized polysaccharide-derived chiral stationary phases (CSPs) combine the benefits of broad application scope and high preparative potential with CSP robustness and universal solvent compatibility. Strategies for efficient and straightforward method development with these CSPs were previously overviewed. In the current study, six CSPs with different structural features in the immobilized series were examined for their complementary properties in separation of enantiomers. Some method development aspects related to polysaccharide-derived CSPs in general and certain specific features observed on these immobilized supports, such as the effects of mobile phase, sample solvent and mobile phase additive on chiral separation, are also discussed.
Chiral Technologies Europe, Bd. Gonthier d'Andernach, 67404 Illkirch Cedex, France. tzhang@chiral.fr
Tong
T
Zhang
Pilar
P
Franco
Dung
D
Nguyen
Ryota
R
Hamasaki
Shoji
S
Miyamoto
Atsushi
A
Ohnishi
Tatsushi
T
Murakami
D002853:Chromatography, Liquid / Q000295:instrumentation / Q000379:methods*; D011134:Polysaccharides / Q000737:chemistry*; D013237:Stereoisomerism
D011134:Polysaccharides