Automation synthesis modules review.
The introduction of (68)Ga labelled tracers has changed the diagnostic approach to neuroendocrine tumours and the availability of a reliable, long-lived (68)Ge/(68)Ga generator has been at the bases of the development of (68)Ga radiopharmacy. The huge increase in clinical demand, the impact of regulatory issues and a careful radioprotection of the operators have boosted for extensive automation of the production process. The development of automated systems for (68)Ga radiochemistry, different engineering and software strategies and post-processing of the eluate were discussed along with impact of automation with regulations.
PET Radiopharmacy, Nuclear Medicine Department, S.Orsola-Malpighi University Hospital, Bologna, Italy. stefano.boschi@aosp.bo.it
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Boschi
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Lodi
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Malizia
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Cicoria
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Marengo
D001331:Automation; D005710:Gallium Radioisotopes; D006573:Heterocyclic Compounds, 1-Ring / Q000737:chemistry; D007553:Isotope Labeling / Q000295:instrumentation / Q000379:methods*; D049268:Positron-Emission Tomography; D011876:Radionuclide Generators; D019275:Radiopharmaceuticals / Q000138:chemical synthesis; D017481:Receptors, Somatostatin / Q000378:metabolism
D005710:Gallium Radioisotopes; D006573:Heterocyclic Compounds, 1-Ring; D019275:Radiopharmaceuticals; D017481:Receptors, Somatostatin; C071349:1,4,7,10-tetraazacyclododecane- 1,4,7,10-tetraacetic acid