Association of adiponectin with hypertension in type 2 diabetic patients: the gender effect.
Adiponectin is an adipokine involved in the regulation of body metabolism and immune response. Circulating levels and/or activity of adiponectin were reported to influence susceptibility to several diseases, including type 2 diabetes mellitus, cardiovascular disease, and metabolic syndrome. In this study, serum adiponectin levels and the association of adiponectin gene (ADIPQO) single-nucleotide polymorphism (G276T SNP) with hypertension in type 2 diabetic patients were examined. Type 2 diabetic patients (n = 449) were recruited and divided into two groups, normotensive (n = 199) and hypertensive (n = 250). Results demonstrated that serum adiponectin levels were significantly higher in normotensive subjects compared with hypertensive subjects (P < .05). When these results were compared according to gender, only female hypertensive diabetic patients showed significantly higher levels of adiponectin (P < .05). In addition, no significant difference in the genotypes and alleles frequencies of ADIPQO G276T SNP was observed between the two groups (P > .05). In conclusion, high circulating levels of adiponectin were found to be associated with hypertension only in type 2 diabetic female patients which might indicate a gender preference.
Department of Medical Laboratory Sciences, Jordan University of Science and Technology, Irbid, Jordan. khabour@just.edu.jo
Omar F
OF
Khabour
Suha H
SH
Wehaibi
Sayer I
SI
Al-Azzam
Karem H
KH
Alzoubi
Zeyad J
ZJ
El-Akawi
D052242:Adiponectin / Q000097:blood* / Q000235:genetics*; D000328:Adult; D000368:Aged; D015415:Biomarkers / Q000097:blood; D001794:Blood Pressure / Q000502:physiology; D016022:Case-Control Studies; D015897:Comorbidity; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000453:epidemiology / Q000503:physiopathology*; D005260:Female; D005787:Gene Frequency / Q000235:genetics; D005838:Genotype; D006801:Humans; D006973:Hypertension / Q000097:blood / Q000453:epidemiology / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide / Q000235:genetics; D012737:Sex Factors
D052242:Adiponectin; D015415:Biomarkers