[Effect of hypoxia on dynamics of HIF-1alpha level in the cerebral cortex and development of adaptation in rats with different resistance to hypoxia].
Hypoxic preconditioning induces two-phase increase of HIF-1alpha expression in the neocortex of low-resistance rats. The first, brief phase appears after each hypoxic episode and rapidly disappears in normoxic conditions. The second increase in of HIF-1alpha expression occurs in 24 hours after the hypoxic episode. The phase-nature of HIF-1alpha expression corresponds to the dynamics of urgent and long-term resistance in low-resistance rats, which suggests the HIF-1alpha involvement in mechanisms of urgent and long-term adaptation. In high-resistance rats, hypoxia preconditioning does not influence the HIF-1alpha protein expression and the adaptation. Severe hypoxia inhibits the HIF-1alpha protein expression in the neocortex of both rat phenotypes, depresses the formation of urgent resistance, and abolishes the induction of long-term adaptation.
Iu I
IuI
Kirova
D000222:Adaptation, Physiological / Q000235:genetics; D000818:Animals; D015153:Blotting, Western; D060467:Disease Resistance / Q000235:genetics; D004591:Electrophoresis, Polyacrylamide Gel; D000860:Hypoxia / Q000235:genetics / Q000378:metabolism* / Q000503:physiopathology; D051795:Hypoxia-Inducible Factor 1, alpha Subunit / Q000037:antagonists & inhibitors / Q000096:biosynthesis*; D008297:Male; D019579:Neocortex / Q000378:metabolism* / Q000503:physiopathology; D051381:Rats; D012720:Severity of Illness Index; D013045:Species Specificity
C497444:Hif1a protein, rat; D051795:Hypoxia-Inducible Factor 1, alpha Subunit