A case of therapy-related acute myeloid leukemia with inv(16)(p13.1q22) after single low-dose iodine-131 treatment for thyroid cancer.
Radioiodine is regularly used in the treatment of thyroid cancer to eliminate residual malignant tissue after thyroidectomy and to treat metastasis. Because of the low dose of radioiodine used to treat thyroid cancer patients, leukemia is an uncommon complication of exposure to radioiodine. Here, we present a patient who developed therapy-related acute myeloid leukemia with inv(16)(p13.1q22);CBFβ-MYH11, eosinophilia, and K-ras mutation and who had been treated with very low-dose radioiodine following total thyroidectomy.
Department of Laboratory Medicine, Gachon University Gil Medical Center, Incheon, Korea.
Ji Hun
JH
Jeong
Jeong Yeal
JY
Ahn
Soon Ho
SH
Park
Mi Jung
MJ
Park
Kyung Hee
KH
Kim
Jun Shik
JS
Hong