Intramolecular direct C-H bond arylation from aryl chlorides: a transition-metal-free approach for facile access of phenanthridines.
A C-H arylation with aryl chloride is made viable through a transition-metal-free approach. In the presence of a simple diol associating with KOt-Bu, various phenanthridine derivatives can be conveniently accessed. In particular, only 10 mol % of simple and inexpensive ethylene glycol is required for this protocol. These results represent the first general examples of aryl chloride/C-H coupling under transition-metal-free conditions.
State Key Laboratory of Chiroscience and Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hong Kong, China.
Yinuo
Y
Wu
Shun Man
SM
Wong
Fei
F
Mao
Tek Long
TL
Chan
Fuk Yee
FY
Kwong
D002712:Chlorides / Q000737:chemistry*; D006860:Hydrogen Bonding; D015394:Molecular Structure; D010617:Phenanthridines / Q000737:chemistry*
D002712:Chlorides; D010617:Phenanthridines