Fragment and conquer: from structure to complexes to function.
In this issue of Structure, Shumilin and colleagues show the power of metabolite screening by means of X-ray crystallography to link an orphan protein domain with an orphan biochemical function. This result paves the way for large-scale functional annotation and sets new objectives for structural genomics.
Atelier de Bio- et Chimie Informatique Structurale, CNRS, UMR5048, Centre de Biochimie Structurale, F-34090 Montpellier, France.
Jean-François
JF
Guichou
Gilles
G
Labesse