CuI controlled C-C and C-N bond formation of heteroaromatics through C(sp3)-H activation.
A new method for C-C and C-N bond formation of heteroaromatics and C(sp(3))-H alkanes was developed with high regioselectivity. The reaction occurred on C8 to give 8-cylcoakylpurines by C-C bond formation only promoted by tBuOOtBu, while it occurred on the amino group to give N6-alkylated purines by C-N bond formation when 2 equiv of CuI were added. A reaction mechanism was also proposed based on our preliminary experimental data.
College of Chemistry and Chemical Engineering, Key Laboratory of Green Chemical Media and Reactions of Ministry of Education, Henan Normal University, No. 46 Jianshe Road, Xinxiang, 453007, China.
Ran
R
Xia
Hong-Ying
HY
Niu
Gui-Rong
GR
Qu
Hai-Ming
HM
Guo