Methylprednisolone aceponate 0.1% in the treatment of pruritic lichenified eczema in a 3-year-old child with chronic atopic dermatitis.
A 3-year-old girl with a > 2-year history of atopic dermatitis (AD) and known egg allergy, presented with an extensive AD flare including exudative eczematous lesions and lichenification on her flexures. The patient reported intense pruritus and showed signs of scratching on her trunk, arms, buttocks and thighs. After 2 weeks of twice-daily application of methylprednisolone aceponate (MPA) 0.1% (Advantan(®)), temporary withdrawal of emollients, and mild bathing/cleanser use, the eczematic condition was considered clear, and marked improvement of all treated lesions (including disappearance of scaling) were observed. No side effects of Advantan were reported; the patient's parents expressed a high level of satisfaction with treatment. Advantan was safe and effective in controlling a severe pruritic flare of chronic AD in a small child.
Department of Pediatric Dermatology, Hospital del Niño Jesús, Madrid, Spain. atorrelo@aedv.es
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Torrelo
D000287:Administration, Topical; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D002675:Child, Preschool; D002908:Chronic Disease; D003876:Dermatitis, Atopic / Q000188:drug therapy* / Q000503:physiopathology; D004485:Eczema / Q000188:drug therapy* / Q000503:physiopathology; D005260:Female; D006801:Humans; D008775:Methylprednisolone / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000627:therapeutic use
D000893:Anti-Inflammatory Agents; C078007:methylprednisolone aceponate; D008775:Methylprednisolone