[Rapid determination of 19 elements in human urine by inductively coupled plasma-mass spectrometry with dynamic reaction cell].
OBJECTIVE
A simple method is proposed for determination of Be, Rb, Sr, Cd, Pb, Cs, Tl, V, Cr, Mn, Ni, Co, Cu,Zn, Sn, Sb, Te, As and Se in urine by using inductively coupled plasma mass spectrometry with dynamic reaction cell.


METHODS
Prior to analysis, samples were diluted (1: 20) in a solution of nitric acid (3%, V/V). The DRC mode was applied to determine the content of V51, Cr52, Mn55, Ni58, Co59, Cu63, Zn64 Sn120, Sb121, Te130, As75 and Se80. For the other elements, the instrument was operated in standard mode.


RESULTS
The method detection limits were 2.7ng/L for Be9, 2.0ng/L for V51, 2.7ng/L for Cr52, 1.5ng/L for Mn55, 3.9ng/L for Ni58, 0.8ng/L for Co59, 5.8ng/L for Cu63, 35.3ng/L for Zn64, 32.4ng/L for As75, 21.1ng/L for Se80,1.4ng/L for Rb85, 4.2ng/ L for Sr88, 1.1 ng/L for Cd 9.1 ng/L for Sn120, 1.1ng/L for Sb121, 8.6ng/L for Te130, 0.1 ng/L for Cs133, 0.2ng/L for Tl205 and 1.0 ng/L for Pb208. The precisions of the method were in the range of 0.3% - 2.6%.


CONCLUSIONS
The proposed method was rapid, accurate and can be used for measurement with simple pre-treatment, less sample and lower cost. The method was also suitable for massive samples in screening and monitoring.
Shenzhen Center for Chronic Disease Control, Shenzhen 518020, China. junwangwh96@gmail.com
Jun
J
Wang
Hongxing
H
Tan
Huijian
H
Liu
Qinqin
Q
Liao
Jian
J
Xu
Xiaoli
X
Liu
D004785:Environmental Pollutants / Q000652:urine*; D006801:Humans; D013058:Mass Spectrometry; D016482:Urinalysis / Q000379:methods
D004785:Environmental Pollutants