Pd-catalyzed synthesis of aryl amines via oxidative aromatization of cyclic ketones and amines with molecular oxygen.
Pd-catalyzed intermolecular aerobic dehydrogenative aromatizations have been developed for the arylation of amines with nonaromatic ketones. Under optimized reaction conditions, primary and secondary amines are selectively arylated in good yields with cyclohexanones and 2-cyclohexen-1-ones in the presence of a Pd-catalyst under an atmosphere of molecular oxygen.
Department of Chemistry and FQRNT Center for Green Chemistry and Catalysis, McGill University, Montreal, QC, H3A 2K6, Canada.
Simon A
SA
Girard
Xiong
X
Hu
Thomas
T
Knauber
Feng
F
Zhou
Marc-Olivier
MO
Simon
Guo-Jun
GJ
Deng
Chao-Jun
CJ
Li
D000588:Amines / Q000138:chemical synthesis* / Q000737:chemistry; D002384:Catalysis; D003512:Cyclohexanones / Q000737:chemistry; D007659:Ketones / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D010084:Oxidation-Reduction; D010100:Oxygen / Q000737:chemistry*; D010165:Palladium / Q000737:chemistry*
D000588:Amines; D003512:Cyclohexanones; D007659:Ketones; D010165:Palladium; D010100:Oxygen