Lipocalin-like prostaglandin D synthase (L-PGDS) concentration in aqueous humour in patients with open-angle glaucoma.
OBJECTIVE
To report on the concentration of lipocalin-like prostaglandin D synthase (L-PGDS) in the aqueous humour (AH) in patients with open-angle glaucoma (OAG).


METHODS
Prospective assessment in 20 patients (13 female, 7 male, mean age 74±10.6 y) who underwent surgery for OAG. AH was sampled and analyzed for L-PGDS concentration. AH from 26 patients (11 female, 15 male, 72.4±14.4 y) without glaucoma who underwent cataract surgery, served as control subjects.


RESULTS
The L-PGDS concentration in the AH sampled from the anterior chamber in the OAG group (5.9±2.4 mg/L) was significantly (P<0.001) higher than in the control group (3.3±1.3 mg/L). There were no significant differences between the concentrations of L-PGDS between the left and the right eye or between genders.


CONCLUSIONS
L-PGDS concentration in the AH of patients with OAG was significantly elevated compared with its concentration in the AH of nonglaucomatous eyes. As L-PGDS is a biologically pluripotent protein, its possible role in glaucoma warrants further examination.
Departments of *Ophthalmology §Laboratory Medicine, Kantonsspital Aarau, Aarau †Eye Clinic, University Hospital of Zurich, Zurich ‡Eye Institute, University of Basel, Basel, Switzerland.
Gregor
G
Bauer
Hanspeter E
HE
Killer
Andreas
A
Forrer
Andreas R
AR
Huber
Gregor P
GP
Jaggi
D000368:Aged; D001082:Aqueous Humor / Q000201:enzymology*; D005260:Female; D005902:Glaucoma, Open-Angle / Q000201:enzymology* / Q000601:surgery; D006801:Humans; D019746:Intramolecular Oxidoreductases / Q000378:metabolism*; D007429:Intraocular Pressure; D054834:Lipocalins / Q000378:metabolism*; D008297:Male; D011446:Prospective Studies; D014130:Trabeculectomy
D054834:Lipocalins; D019746:Intramolecular Oxidoreductases; C022466:prostaglandin R2 D-isomerase