The synergic effect of regular exercise and resveratrol on kainate-induced oxidative stress and seizure activity in mice.
The synergic effect of regular exercise and resveratrol, a polyphenolic compound with potent antioxidant activity, was investigated against kainate-induced seizures and oxidative stress in mice. After 6 weeks of swimming training, the total body weight decreased and the blood concentration of lactate stabilized statistically in comparison with the sedentary mice, indicate that the training program increased the aerobic resistance of mice. Kainate (30 mg/kg) evoked seizure activity 5 min after injection, and seizure activity was measured seizure rating scores every 5 min up to 2 h. As previously well known experiments, regular exercise and resveratrol (40 mg/kg, daily supplementation for 6 weeks) have an inhibitory effect on kainate-induced seizure activity and oxidative stress. In particularly, a synergistic cooperation of regular exercise and resveratrol was observed in seizure activity, mortality and oxidative stress especially in SOD activity. These results suggest that regular exercise along with an anti-convulsant agent such as resveratrol could be a more efficient method for the prevention of seizure development than exercise alone.
Health and Exercise Science Laboratory, Institute of Sports Science, Seoul National University, Seoul, Korea.
Hee-jae
HJ
Kim
Il-Kon
IK
Kim
Wook
W
Song
Jin
J
Lee
Sok
S
Park
D015308:Anaerobic Threshold / Q000187:drug effects / Q000502:physiology; D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D001835:Body Weight / Q000187:drug effects / Q000502:physiology; D002374:Catalase / Q000378:metabolism; D007608:Kainic Acid / Q000494:pharmacology*; D019344:Lactic Acid / Q000378:metabolism; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D018384:Oxidative Stress / Q000187:drug effects*; D010805:Physical Conditioning, Animal / Q000502:physiology*; D000077185:Resveratrol; D012640:Seizures / Q000139:chemically induced* / Q000503:physiopathology / Q000517:prevention & control*; D013267:Stilbenes / Q000494:pharmacology*; D013482:Superoxide Dismutase / Q000378:metabolism; D013550:Swimming / Q000502:physiology
D000975:Antioxidants; D013267:Stilbenes; D019344:Lactic Acid; D002374:Catalase; D013482:Superoxide Dismutase; D000077185:Resveratrol; D007608:Kainic Acid