Exploring the therapeutic space around NAD+.
NAD(+) is a central metabolite in the cell. Changes in NAD(+) abundance and the activity of NAD(+)-dependent enzymes, such as the sirtuins, are at the core of metabolic/mitochondrial diseases, such as obesity and diabetes, and of cancer and neurodegeneration. Here, we discuss how maintaining or raising NAD(+) levels can improve metabolism and prevent age-related functional decline and associated disease, and how basic scientific discoveries in the NAD(+) signaling pathway are being translated to the clinic.
Laboratory Genetic Metabolic Diseases, Academic Medical Center, University of Amsterdam, Amsterdam, Netherlands. r.h.houtkooper@amc.nl
Riekelt H
RH
Houtkooper
Johan
J
Auwerx
D036541:ADP-ribosyl Cyclase / Q000378:metabolism; D004734:Energy Metabolism; D006801:Humans; D008659:Metabolic Diseases / Q000378:metabolism; D008928:Mitochondria / Q000378:metabolism*; D028361:Mitochondrial Diseases / Q000378:metabolism; D009243:NAD / Q000378:metabolism*; D011065:Poly(ADP-ribose) Polymerases / Q000378:metabolism; D015398:Signal Transduction; D037761:Sirtuins / Q000378:metabolism
D009243:NAD; D011065:Poly(ADP-ribose) Polymerases; D036541:ADP-ribosyl Cyclase; D037761:Sirtuins