Prion remains infectious after passage through digestive system of American crows (Corvus brachyrhynchos).
Avian scavengers, such as American crows (Corvus brachyrhynchos), have potential to translocate infectious agents (prions) of transmissible spongiform encephalopathy (TSE) diseases including chronic wasting disease, scrapie, and bovine spongiform encephalopathy. We inoculated mice with fecal extracts obtained from 20 American crows that were force-fed material infected with RML-strain scrapie prions. These mice all evinced severe neurological dysfunction 196-231 d postinoculation (x =198; 95% CI: 210-216) and tested positive for prion disease. Our results suggest a large proportion of crows that consume prion-positive tissue are capable of passing infectious prions in their feces (ˆp=1.0; 95% CI: 0.8-1.0). Therefore, this common, migratory North American scavenger could play a role in the geographic spread of TSE diseases.
United States Department of Agriculture, Animal and Plant Health Inspection Service, Wildlife Services, National Wildlife Research Center, Fort Collins, Colorado, USA. kurt.c.vercauteren@aphis.usda.gov
Kurt C
KC
VerCauteren
John L
JL
Pilon
Paul B
PB
Nash
Gregory E
GE
Phillips
Justin W
JW
Fischer
D000818:Animals; D046368:Crows / Q000378:metabolism*; D004064:Digestive System / Q000378:metabolism*; D004797:Enzyme-Linked Immunosorbent Assay; D051379:Mice; D008810:Mice, Inbred C57BL; D011328:Prions / Q000472:pathogenicity*; D012608:Scrapie / Q000635:transmission; D016019:Survival Analysis
D011328:Prions