Surveillance of 16 respiratory viruses in patients with influenza-like illness in Nanjing, China.
Much less is known about the etiology of influenza-like illness in China. A continuous surveillance of 16 respiratory viruses was conducted from November 2010 to October 2011 of outpatients with influenza-like illness in Nanjing, China. The two largest general hospitals and a provincial virus laboratory in Nanjing participated in this study. Throat swabs were collected from outpatients during medical visits for influenza-like illness and were tested for 16 respiratory viruses using PCR. Three hundred seventeen viruses were detected in samples from 246 (50.6%) patients with influenza-like illness. The viruses found mostly commonly were influenza, rhinovirus, hCoV HKU1, and adenovirus. The identification rates of respiratory viruses differed significantly among different sampling seasons (P = 0.0002). The rates of influenza A and hCoV HKU1 were much higher during the influenza-like illness winter peak than during the influenza-like illness summer peak and other months. Co-infections were detected in 57 (11.7%) patients and were found most commonly in adults older than 60 years. RSV was detected in 5.9% and 2.6% of patients who were 0-5 and 6-15 years old, respectively, but was not detected in other age groups. This study confirmed that multiple respiratory viruses may circulate concurrently in the population and account for a large proportion of influenza-like illness. In addition to influenza virus, hCoV HKU1 may be associated with the influenza-like illness winter peak in Nanjing, China.
Jiangsu Provincial Center for Disease Control and Prevention, Nanjing, China. huox@foxmail.com
Xiang
X
Huo
Yuanfang
Y
Qin
Xian
X
Qi
Rongqiang
R
Zu
Fenyang
F
Tang
Liang
L
Li
Zhibin
Z
Hu
Fengcai
F
Zhu
D000293:Adolescent; D000328:Adult; D002648:Child; D002675:Child, Preschool; D002681:China / Q000453:epidemiology; D060085:Coinfection / Q000175:diagnosis / Q000821:virology; D004279:DNA, Viral / Q000235:genetics; D004770:Enterovirus / Q000302:isolation & purification; D006801:Humans; D007223:Infant; D007251:Influenza, Human / Q000175:diagnosis / Q000453:epidemiology / Q000821:virology; D008875:Middle Aged; D009975:Orthomyxoviridae / Q000302:isolation & purification*; D010850:Picornaviridae Infections / Q000175:diagnosis / Q000453:epidemiology / Q000821:virology; D016133:Polymerase Chain Reaction; D011159:Population Surveillance / Q000379:methods*; D012367:RNA, Viral / Q000235:genetics; D018357:Respiratory Syncytial Virus Infections / Q000175:diagnosis / Q000453:epidemiology / Q000821:virology; D012136:Respiratory Syncytial Viruses / Q000302:isolation & purification; D012140:Respiratory Tract Diseases / Q000175:diagnosis / Q000453:epidemiology* / Q000821:virology*; D012229:Rhinovirus / Q000302:isolation & purification; D012621:Seasons; D055815:Young Adult
D004279:DNA, Viral; D012367:RNA, Viral