Safety assessment of alkyl PEG ethers as used in cosmetics.
The CIR Expert Panel assessed the safety of Alkyl PEG Ethers as used in cosmetics. These ingredients primarily function in cosmetics as surfactants, and some have additional functions as skin-conditioning agents, fragrance ingredients, and emulsion stabilizers. The Panel reviewed available relevant animal and clinical data, as well as information from previous CIR reports; when data were not available for individual ingredients, the Panel extrapolated from the existing data to support safety. The Panel concluded that the Alkyl PEG ethers are safe as used when formulated to be nonirritating, and the same applies to future alkyl PEG ether cosmetic ingredients that vary from those ingredients recited herein only by the number of ethylene glycol repeat units.
Cosmetic Ingredient Review, 1101 17th Street NW, Washington, DC 20036, USA. cirinfo@cir-safety.org
Monice M
MM
Fiume
Bart
B
Heldreth
Wilma F
WF
Bergfeld
Donald V
DV
Belsito
Ronald A
RA
Hill
Curtis D
CD
Klaassen
Daniel
D
Liebler
James G
JG
Marks
Ronald C
RC
Shank
Thomas J
TJ
Slaga
Paul W
PW
Snyder
F Alan
FA
Andersen
D000279:Administration, Cutaneous; D000478:Alkylation; D000818:Animals; D003257:Consumer Product Safety; D003358:Cosmetics / Q000737:chemistry* / Q000633:toxicity; D003879:Dermatologic Agents / Q000008:administration & dosage / Q000737:chemistry / Q000493:pharmacokinetics / Q000633:toxicity; D004987:Ethers / Q000008:administration & dosage / Q000737:chemistry / Q000493:pharmacokinetics / Q000633:toxicity*; D006801:Humans; D007928:Lethal Dose 50; D019055:No-Observed-Adverse-Effect Level; D011092:Polyethylene Glycols / Q000008:administration & dosage / Q000737:chemistry / Q000493:pharmacokinetics / Q000633:toxicity*; D017592:Skin Care / Q000009:adverse effects; D013501:Surface-Active Agents / Q000008:administration & dosage / Q000493:pharmacokinetics / Q000633:toxicity*; D018675:Toxicity Tests
D003358:Cosmetics; D003879:Dermatologic Agents; D004987:Ethers; D013501:Surface-Active Agents; D011092:Polyethylene Glycols