[A new strategy for locally advanced rectal cancer using a nerve-regeneration tube].
In surgery for the treatment of locally advanced rectal cancers affecting the intrapelvic nerves, when an affected nerve is resected in extended surgery to achieve radical cure, the resection results in functional disturbance in the organ it controls. On the other hand, when the nerve remains intact after function-preserving surgery, the risk of local recurrence is high because of possible remnant cancer cells. Thus in performing surgery to treat such cancers, there is a dilemma between the selection of extended surgery or function-preserving surgery. To resolve this, we devised a new strategy in which the cancer is removed radically in extended surgery and organ function is recovered by regeneration of the resected nerve using a nerve-regenerating tube. After animal experiments had confirmed the regeneration of nerve functions with nerve-regenerating tubes, we followed this new strategy to treat 17 patients with locally advanced cancers who underwent extended surgery plus the regeneration of the resected nerve using the nerve-regenerating tube. Nerve function was restored to a significant degree in 16 of the 17 patients.
Faculty of Medical Sciences, Doshisha University, Kyoto, Japan.
Akeo
A
Hagiwara
Eigo
E
Otsuji
Hisakazu
H
Yamagishi
D006801:Humans; D009416:Nerve Regeneration / Q000502:physiology*; D012004:Rectal Neoplasms / Q000601:surgery*; D044968:Regenerative Medicine / Q000379:methods*