Do zwitterionic species exist in the non-enzymatic peptide bond formation?
The use of proper computational methods and models has allowed answering the controversial question of whether zwitterionic species exist in the mechanism of peptide bond synthesis in aqueous solution. In fact, the different conformations of zwitterionic species open the door to different mechanistic paths.
Departament de Química Física, Universitat de Valéncia, 46100 Burjassot, Spain.
Katarzyna
K
Świderek
Iñaki
I
Tuñón
Sergio
S
Martí
Vicent
V
Moliner
Juan
J
Bertrán
D007477:Ions / Q000737:chemistry; D008958:Models, Molecular; D010455:Peptides / Q000737:chemistry*; D011789:Quantum Theory; D013816:Thermodynamics
D007477:Ions; D010455:Peptides