Synthesis and characterization of a chromium(V) cis-1,2-cyclohexanediolato complex: a model of reactive intermediates in chromium-induced cancers.
Stabilization of chromium(V) by biological 1,2-diolato ligands, e.g., carbohydrates and glycoproteins, is postulated to be crucial for both the chromium(VI)-induced carcinogenicity and chromium(III) antidiabetic activities. Close structural mimics of biologically relevant chromium(V) 1,2-diolato complexes, M[Cr(V)O(chd)(2)] [chd = cis-1,2-cyclohexanediolato(2-)], were synthesized and characterized by X-ray crystallography (M = Na) or by spectroscopic techniques, including X-ray absorption spectroscopy (M = K). This is the first structurally characterized chromium(V) complex with a cyclic diolato ligand.
Fachbereich Chemie, Philipps-Universität Marburg, Hans-Meerwein Strasse, D-35032 Marburg, Germany.
Ruben
R
Bartholomäus
Klaus
K
Harms
Aviva
A
Levina
Peter A
PA
Lay
D002857:Chromium / Q000009:adverse effects / Q000737:chemistry*; D056831:Coordination Complexes / Q000009:adverse effects / Q000737:chemistry*; D018360:Crystallography, X-Ray; D003510:Cyclohexanes / Q000009:adverse effects / Q000737:chemistry*; D006801:Humans; D008024:Ligands; D008958:Models, Molecular; D009369:Neoplasms / Q000139:chemically induced
D056831:Coordination Complexes; D003510:Cyclohexanes; D008024:Ligands; D002857:Chromium; C506365:Cyclohexane