Micafungin for Candida albicans pacemaker-associated endocarditis: a case report and review of the literature.
We report on the treatment with micafungin of a pacemaker-associated endocarditis due to Candida albicans. Antifungal therapy was able to reduce vegetation size from 5 to 1 cm making possible the transvenous removal of the device without a high risk of pulmonary embolism. Noteworthy, a high micafungin concentration was documented into the lead vegetation (10 μg/g of vegetation tissue) and this may have contributed to the striking size reduction of vegetation.
U.O. Malattie Infettive, Azienda Ospedaliera Universitaria Pisana, Pisa, Italy.
Carlo
C
Tascini
Maria Grazia
MG
Bongiorni
Enrico
E
Tagliaferri
Antonello
A
Di Paolo
Sarah
S
Flammini
Ezio
E
Soldati
Alessandro
A
Leonildi
Andrea
A
Di Cori
Francesco
F
Menichetti
D000368:Aged; D000935:Antifungal Agents / Q000627:therapeutic use*; D002176:Candida albicans / Q000187:drug effects / Q000302:isolation & purification*; D054714:Echinocandins / Q000627:therapeutic use*; D004452:Echocardiography; D004696:Endocarditis / Q000175:diagnosis* / Q000188:drug therapy* / Q000382:microbiology / Q000473:pathology; D005260:Female; D006801:Humans; D055666:Lipopeptides / Q000627:therapeutic use*; D000077551:Micafungin; D008826:Microbial Sensitivity Tests; D010138:Pacemaker, Artificial / Q000009:adverse effects*; D019736:Prostheses and Implants / Q000009:adverse effects*; D016896:Treatment Outcome
D000935:Antifungal Agents; D054714:Echinocandins; D055666:Lipopeptides; D000077551:Micafungin