eNOS tag SNP haplotypes in hypertensive disorders of pregnancy.
Haplotypes formed by polymorphisms (T-786C, rs2070744; a variable number of tandem repeats in intron 4, and Glu298Asp, rs1799983) of the eNOS gene were associated previously with gestational hypertension (GH) and preeclampsia (PE). However, no study has explored the Tag SNPs rs743506 and rs7830 in these disorders. The aim of the current study was to compare the distribution of the genotypes and haplotypes formed by the five eNOS polymorphisms mentioned among healthy pregnant (HP, n=122), GH (n=138), and PE (n=157). The haplotype formed by "C b G G C" was more frequent in HP compared to GH and PE (p=0.0071), which is supported by previous findings that demonstrated the association of the combination "C b G" with a higher level of nitrite (NO marker). Our results suggest a protective effect of the haplotype "C b G G C" against the development of hypertensive disorders of pregnancy.
Center of Postgraduation and Research - Santa Casa of Belo Horizonte, Belo Horizonte, Brazil.
Ludmila
L
Muniz
Marcelo R
MR
Luizon
Ana C T
AC
Palei
Riccardo
R
Lacchini
Geraldo
G
Duarte
Ricardo C
RC
Cavalli
Jose E
JE
Tanus-Santos
Valeria C
VC
Sandrim
D000328:Adult; D000483:Alleles; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D006239:Haplotypes; D006801:Humans; D046110:Hypertension, Pregnancy-Induced / Q000235:genetics* / Q000503:physiopathology; D007438:Introns; D052250:Nitric Oxide Synthase Type III / Q000235:genetics* / Q000378:metabolism; D009573:Nitrites / Q000097:blood; D020641:Polymorphism, Single Nucleotide; D011225:Pre-Eclampsia / Q000235:genetics / Q000503:physiopathology; D011247:Pregnancy; D055815:Young Adult
D009573:Nitrites; C496314:NOS3 protein, human; D052250:Nitric Oxide Synthase Type III