Correlation between serum C1q-adiponectin/total adiponectin ratio and polyvascular lesions detected by vascular ultrasonography in Japanese type 2 diabetics.
OBJECTIVE
Atherosclerosis is a disease of blood vessels. Adiponectin is a biomarker of atherosclerosis. Adiponectin and C1q form a protein complex in human blood, and serum C1q-binding adiponectin (C1q-APN) can be measured. We investigated the relationship between various serum adiponectin parameters and polyvascular atherosclerosis score assessed by vascular ultrasonography, in subjects with type 2 diabetes mellitus (T2DM).


METHODS
The study subjects were 108 outpatients with T2DM who underwent evaluation for atherosclerosis by vascular ultrasonography. Polyvascular atherosclerosis score represented the sum of atherosclerotic abnormalities in the aorta, carotid, renal and common iliac arteries. Blood C1q, total-adiponectin (Total-APN), high molecular weight-adiponectin (HMW-APN) and C1q-APN were measured by enzyme-linked immunosorbent assays. The estimated visceral fat area (eVFA) was measured by bioelectrical impedance.


RESULTS
Polyvascular atherosclerosis score correlated only with the C1q-APN/Total-APN ratio (p=0.018 for trend). There were no significant relationships between various adiponectin parameters and carotid maximum intima-media thickness and ankle-brachial index. Age-, sex-, eVFA-adjusted multiple logistic regression analysis that included the above variables identified serum C1q-APN/Total-APN ratio as the only significant and independent determinant of polyvascular atherosclerosis score.


CONCLUSIONS
Serum C1q-APN/Total-APN ratio correlates with atherosclerosis detected by polyvascular vascular ultrasonography, independent of gender and visceral adiposity, in T2DM.
Department of Metabolic Medicine, Graduate School of Medicine, Osaka University, Osaka, Japan.
Ayumu
A
Hirata
Ken
K
Kishida
Hironori
H
Kobayashi
Hideaki
H
Nakatsuji
Tohru
T
Funahashi
Iichiro
I
Shimomura
D052242:Adiponectin / Q000097:blood* / Q000378:metabolism; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001158:Arteries / Q000000981:diagnostic imaging / Q000378:metabolism / Q000473:pathology; D050197:Atherosclerosis / Q000097:blood* / Q000000981:diagnostic imaging / Q000378:metabolism / Q000473:pathology*; D002097:C-Reactive Protein / Q000378:metabolism; D015922:Complement C1q / Q000378:metabolism*; D003924:Diabetes Mellitus, Type 2 / Q000097:blood* / Q000000981:diagnostic imaging / Q000378:metabolism / Q000473:pathology*; D005260:Female; D006801:Humans; D015850:Interleukin-6 / Q000097:blood; D050152:Intra-Abdominal Fat / Q000378:metabolism; D007564:Japan; D008297:Male; D008875:Middle Aged; D012372:ROC Curve; D018709:Statistics, Nonparametric; D017392:Thiobarbituric Acid Reactive Substances / Q000378:metabolism; D014463:Ultrasonography
D052242:Adiponectin; D015850:Interleukin-6; D017392:Thiobarbituric Acid Reactive Substances; D015922:Complement C1q; D002097:C-Reactive Protein