Concealed long QT syndrome and intractable partial epilepsy: a case report.
Herein, we describe a patient with concealed type 2 long QT syndrome with concomitant electroencephalogram-documented epilepsy. Although syncope in patients with long QT syndrome is common and often secondary to cerebral hypoxia after a protracted ventricular arrhythmia, this article demonstrates the importance of avoiding "tunnel vision" as patients with long QT syndrome could also have a primary seizure disorder. Identification of the etiology underlying seizurelike activity is paramount in instituting effective therapy. Furthermore, we theorize that abnormal KCHN2-encoded potassium channel repolarization in the brain could result in epilepsy and arrhythmias in long QT syndrome.
Division of Pediatric Cardiology, Mayo Clinic, Rochester, MN 55905, USA.
Jason H
JH
Anderson
Johan Martijn
JM
Bos
Fredric B
FB
Meyer
Gregory D
GD
Cascino
Michael J
MJ
Ackerman
D000293:Adolescent; D003937:Diagnosis, Differential; D003951:Diagnostic Errors; D004569:Electroencephalography; D004828:Epilepsies, Partial / Q000175:diagnosis* / Q000209:etiology*; D005260:Female; D006801:Humans; D008133:Long QT Syndrome / Q000150:complications* / Q000175:diagnosis*