Prognostic impact of chronic kidney disease on 10-year clinical outcomes among patients with acute coronary syndrome.
BACKGROUND
Chronic kidney disease (CKD) is closely associated with a higher risk of cardiovascular disease. However, whether patients with acute coronary syndrome (ACS) and CKD are at increased risk for long-term mortality after coronary revascularization remains unknown.


RESULTS
Data from consecutive patients with ACS who had undergone coronary revascularization, including percutaneous coronary intervention (PCI) and coronary artery bypass surgery (CABG) were analyzed. The estimated glomerular filtration rate (eGFR) was calculated using the current Japanese equation and CKD was defined as eGFR < 60 mL/min/1.73 m(2). Among 375 enrolled patients with ACS, 75 (20.0%) had CKD. During a follow-up period of 10.0 ± 3.4 years, the total number of deaths was 80 (21.3%), of which 36 (9.6%) were due to cardiovascular causes. Kaplan-Meier analysis showed that the presence of CKD was associated with a significant increase in mortality from all causes (log-rank test, p<0.001) and cardiovascular mortality (p<0.001). Cox proportional-hazard analysis revealed that CKD increased the risk of mortality with a hazard ratio of 2.31 (95% confidence interval (CI): 1.25-4.29, p=0.008) and of cardiovascular death with a hazard ratio of 3.76 (95% CI: 1.60-8.80, p=0.002) in patients with ACS.


CONCLUSIONS
CKD is a powerful determinant of long-term all-cause and cardiovascular mortality after ACS.
Department of Cardiovascular Medicine, Juntendo University, School of Medicine, Tokyo, Japan.
Tomotaka
T
Dohi
Takatoshi
T
Kasai
Katsumi
K
Miyauchi
Kiyoshi
K
Takasu
Kan
K
Kajimoto
Naozumi
N
Kubota
Atsushi
A
Amano
Hiroyuki
H
Daida
D054058:Acute Coronary Syndrome / Q000209:etiology* / Q000401:mortality / Q000628:therapy*; D001026:Coronary Artery Bypass; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D053208:Kaplan-Meier Estimate; D008297:Male; D008875:Middle Aged; D062645:Percutaneous Coronary Intervention / Q000401:mortality*; D011379:Prognosis; D016016:Proportional Hazards Models; D051436:Renal Insufficiency, Chronic / Q000150:complications*; D012189:Retrospective Studies; D012306:Risk; D013997:Time Factors