Maintaining a competitive edge: new rules for peripheral T cell homeostasis.
The contraction of T cell populations after immune responses is poorly understood. In this issue of Immunity, Singh et al. show that "deletor" T cells regulate the frequency of antigen-specific T cells by competing for shared subthreshold ligands.
Medical Research Council Centre for Immune Regulation, University of Birmingham Medical School, UK. l.s.walker@bham.ac.uk
Lucy S K
LS
Walker