Safety assessment of stearyl heptanoate and related stearyl alkanoates as used in cosmetics.
Stearyl heptanoate is an ester of stearyl alcohol and heptanoic acid that functions in cosmetics as a skin conditioning agent and is in the general class of chemicals called stearyl alkanoates. Stearyl caprylate, stearyl palmitate, stearyl stearate, stearyl behenate, and stearyl olivate are stearyl alkanoates with similar chemical structures, toxicokinetics, and functions in cosmetics. These water-insoluble stearyl alkanoates, when metabolized, yield stearyl alcohol and a corresponding fatty acid. The available information supports the safety of all of the related stearyl alkanoates. The Expert Panel concluded that stearyl heptanoate, stearyl caprylate, stearyl palmitate, stearyl stearate, stearyl behenate, and stearyl olivate are safe in the present practices of use and concentration.
Cosmetic Ingredient Review, 1101 17th Street NW, Washington, DC 20036, USA. cirinfo@cir-safety.org
Monice M
MM
Fiume
Wilma F
WF
Bergfeld
Donald V
DV
Belsito
Ronald A
RA
Hill
Curtis D
CD
Klaassen
Daniel
D
Liebler
James G
JG
Marks
Ronald C
RC
Shank
Thomas J
TJ
Slaga
Paul W
PW
Snyder
F Alan
FA
Andersen
D000279:Administration, Cutaneous; D000818:Animals; D003257:Consumer Product Safety; D003358:Cosmetics / Q000737:chemistry* / Q000633:toxicity; D003879:Dermatologic Agents / Q000008:administration & dosage / Q000737:chemistry / Q000633:toxicity*; D006537:Heptanoates / Q000008:administration & dosage / Q000737:chemistry / Q000633:toxicity*; D006801:Humans; D017592:Skin Care / Q000009:adverse effects; D013228:Stearates / Q000008:administration & dosage / Q000737:chemistry / Q000633:toxicity*; D018675:Toxicity Tests; D014885:Waxes / Q000737:chemistry / Q000633:toxicity*
D003358:Cosmetics; D003879:Dermatologic Agents; D006537:Heptanoates; D013228:Stearates; D014885:Waxes; C578960:stearyl heptanoate; C530758:stearyl stearate