Clonal structure of Staphylococcus aureus colonizing children with sickle cell anaemia and healthy controls.
Children with sickle cell anaemia (SCA) might carry hospital-associated bacterial lineages due to frequent hospital stays and antibiotic treatments. In this study we compared Staphylococcus aureus from SCA patients (n=73) and healthy children (n=143) in a cross-sectional study in Gabon. S. aureus carriage did not differ between children with SCA (n=34, 46∙6%) and controls matched for age, residence and sex (n=67, 46∙9%). Both groups shared similar S. aureus genotypes. This finding points towards a transmission of S. aureus between both groups in the community. We conclude that resistance rates from population-based studies with healthy participants could therefore also be used to guide treatment and prophylaxis of endogenous infections in children with SCA despite a different selection pressure.
Medical Research Unit, Albert Schweitzer Hospital Lambaréné, Lambaréné, Gabon. frieder.schaumburg@ukmuenster.de
F
F
Schaumburg
B
B
Biallas
A S
AS
Alabi
M P
MP
Grobusch
E N
EN
Feugap
B
B
Lell
A
A
Mellmann
G
G
Peters
P G
PG
Kremsner
K
K
Becker
A A
AA
Adegnika
D000755:Anemia, Sickle Cell / Q000150:complications* / Q000453:epidemiology; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001427:Bacterial Toxins / Q000235:genetics* / Q000378:metabolism; D015373:Bacterial Typing Techniques; D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D003430:Cross-Sectional Studies; D024881:Drug Resistance, Bacterial; D005098:Exotoxins / Q000235:genetics* / Q000378:metabolism; D005260:Female; D005681:Gabon / Q000453:epidemiology; D006801:Humans; D007956:Leukocidins / Q000235:genetics* / Q000378:metabolism; D008297:Male; D058885:Multilocus Sequence Typing; D016133:Polymerase Chain Reaction; D012307:Risk Factors; D013203:Staphylococcal Infections / Q000150:complications* / Q000453:epidemiology; D013205:Staphylococcal Protein A / Q000235:genetics / Q000378:metabolism; D013211:Staphylococcus aureus / Q000145:classification* / Q000187:drug effects / Q000235:genetics / Q000378:metabolism
D000900:Anti-Bacterial Agents; D001427:Bacterial Toxins; D005098:Exotoxins; D007956:Leukocidins; C078284:Panton-Valentine leukocidin; D013205:Staphylococcal Protein A