[Study of the mutagenic activity of petroleum upon chronic exposure in laboratory animals].
A metaphase chromosome analysis method was used to evaluate the mutagenic activity of volatile petroleum fractions in chronically intoxicated rats. The findings indicate that chronic inhalation exposure of the rats to volatile petroleum fractions at different concentrations results in a significant (2.5-fold) increase, compared to the spontaneous level, in the occurrence of chromosomal aberrations in the bone marrow cells in a number of generations. In addition to chromosomal structural abnormalities, there are genomic changes (aneuploidy, polyploidy). There is a tendency towards an increased rate of petroleum-induced chromosomal aberrations in a number of generations (P, F1, and F2) in the rat bone marrow cells. The maximum mutagenic effect of volatile petroleum fractions was found when used at concentrations of 10 and 100 mg/l upon long-term chronic exposure during three generations (P1, F1, and F2). The findings are indicative of the mutagenic activity of volatile petroleum fractions, which is likely to pose a potential risk from environmental pollution to biota and population health in the area of intensive oil extraction and refining.
D000782:Aneuploidy; D000818:Animals; D001854:Bone Marrow Cells / Q000166:cytology / Q000187:drug effects; D002869:Chromosome Aberrations / Q000139:chemically induced*; D004787:Environmental Pollution / Q000009:adverse effects*; D019570:Inhalation Exposure; D009152:Mutagenicity Tests; D009153:Mutagens / Q000008:administration & dosage / Q000633:toxicity*; D010578:Petroleum / Q000633:toxicity*; D011123:Polyploidy; D051381:Rats; D012306:Risk; D013997:Time Factors
D009153:Mutagens; D010578:Petroleum