Titanocene-catalyzed multicomponent coupling approach to diarylethynyl methanes.
A titanocene-catalyzed multicomponent coupling to provide diarylethynyl methanes is described. By combining the multifunctionality of Cp(2)TiCl(2) with the traceless dielectrophilicity of aryl aldehydes, all-carbon tertiary centers are obtained in 55-99% yield.
Department of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, Indiana 46556, USA.
Joseph B
JB
Gianino
Brandon L
BL
Ashfeld