Osteoclastogenesis inhibitory effect of ergosterol peroxide isolated from Pleurotus eryngii.
Ergosterol peroxide was isolated from the ethanol extract of Pleurotus eryngii as an inhibitor of osteoclast differentiation. This compound showed an inhibitory effect in a dose-dependent manner and an inhibition rate of up to 62% with low cytotoxicity, even at a concentration as low as 1.0 microg/mL.
Department of Agro-enviromental Sciences, Faculty of Agriculture, Kyushu University, Fukuoka 812-8581, Japan.
Satoru
S
Yokoyama
Tran Hai
TH
Bang
Kuniyoshi
K
Shimizu
Ryuichiro
R
Kondo
D000818:Animals; D002470:Cell Survival / Q000187:drug effects; D002478:Cells, Cultured; D004305:Dose-Response Relationship, Drug; D004875:Ergosterol / Q000031:analogs & derivatives* / Q000494:pharmacology; D051379:Mice; D010010:Osteoclasts / Q000166:cytology / Q000187:drug effects*; D020076:Pleurotus / Q000737:chemistry*
C036071:ergosterol-5,8-peroxide; D004875:Ergosterol