Outcome of relapse after allogeneic stem cell transplant in patients with acute myeloid leukemia.
Although allogeneic stem cell transplant (Allo-SCT) is an effective treatment for high-risk acute myeloid leukemia (AML), relapses remain a major cause of treatment failure. There is currently no standard of care for post-transplant relapse of AML, but the increasing numbers of investigational agents in this setting require a better knowledge of their outcome. We retrospectively evaluated the efficacy of salvage therapies in 54 patients with AML relapsing after Allo-SCT. Twenty-four patients received intensive salvage treatment (17 non-intensive chemotherapy, 13 supportive care). Complete remissions (CRs) were seen only in the group who received intensive salvage (CR rate: 17/24 [71%]). One-year overall survival was 19% (median: 3.4 months) in the whole study group and 33% in the intensive savage group (vs. 7% for patients without intensive salvage, p = 0.004). Factors influencing overall survival (OS) were: time to relapse after Allo-SCT (hazard ratio [HR]: 3.7 [1.6-8.8]) and performance status (PS) at relapse (HR: 2.2 [1.1-4.4]) by multivariate analysis. Our results confirm the poor prognosis of AML relapse after Allo-SCT. In selected patients salvage chemotherapy produces CRs, but these are short lived. Other strategies aiming at modulating immune antileukemic activity have to be developed.
Hematology Department, Institut Paoli-Calmettes, Marseille, France.
Raynier
R
Devillier
Roberto
R
Crocchiolo
Anne
A
Etienne
Thomas
T
Prebet
Aude
A
Charbonnier
Sabine
S
Fürst
Jean
J
El-Cheikh
Evelyne
E
D'Incan
Jérôme
J
Rey
Catherine
C
Faucher
Didier
D
Blaise
Norbert
N
Vey
D000293:Adolescent; D000328:Adult; D000368:Aged; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000175:diagnosis / Q000401:mortality / Q000628:therapy*; D008875:Middle Aged; D011379:Prognosis; D012008:Recurrence; D016879:Salvage Therapy; D014184:Transplantation, Homologous; D016896:Treatment Outcome; D055815:Young Adult