Atypical E2Fs drive atypical cell cycles.
It is well documented that polyploid cells exist in mammalian tissues such as the placenta and liver, but their function and the mechanisms for their formation have remained elusive. Two studies now identify a role for atypical E2F transcription factors in promoting polyploidy in mammals and challenge present theories about the function of polyploidy.
Curriculum in Genetics and Molecular Biology, University of North Carolina, Chapel Hill, North Carolina 27599, USA.
Joy H
JH
Meserve
Robert J
RJ
Duronio
D000818:Animals; D017209:Apoptosis / Q000235:genetics / Q000502:physiology; D002453:Cell Cycle / Q000235:genetics / Q000502:physiology*; D050684:E2F Transcription Factors / Q000235:genetics / Q000378:metabolism*; D062951:Endoreduplication / Q000235:genetics / Q000502:physiology; D005260:Female; D005838:Genotype; D006801:Humans; D008954:Models, Biological; D011123:Polyploidy; D011247:Pregnancy
D050684:E2F Transcription Factors