[Oligomerization of human and viral 7TM proteins: a new viral strategy to manipulate host cells].
G protein-coupled receptors (GPCR), also called seven transmembrane domain (7TM) proteins, represent the largest family of membrane receptors with approximately 900 members in humans. Although a substantial number of 7TM proteins have been matched with endogenous ligands, for many of them no ligand has been identified raising questions about their function. Ligand-independent functions have been proposed for several of these so-called orphan 7TM proteins such as the modulation of the function of 7TM proteins with identified ligand through the formation of heteromeric complexes. Interestingly, viruses are using a similar strategy to hijack the host cell signaling machinery and to promote virus replication and dissemination. Indeed, to affect host cell function, several viruses encode orphan 7TM proteins that heteromerize either with other virally-encoded or with host-encoded 7TM proteins with identified ligands. This highlights the strategic importance of 7TM protein signaling and heteromerization for the regulation of cellular homeostasis.
Université Paris Descartes, Sorbonne Paris-Cité, Paris, France. ralf.jockers@inserm.fr
Ralf
R
Jockers
Florence
F
Gbahou
Kenjiro
K
Tadagaki
Maud
M
Kamal
D054884:Host-Pathogen Interactions / Q000502:physiology*; D006801:Humans; D057131:Immune Evasion / Q000502:physiology; D008565:Membrane Proteins / Q000737:chemistry / Q000378:metabolism; D008954:Models, Biological; D055503:Protein Multimerization / Q000502:physiology*; D019707:Receptors, Chemokine / Q000378:metabolism / Q000502:physiology; D043562:Receptors, G-Protein-Coupled / Q000378:metabolism*; D014764:Viral Proteins / Q000737:chemistry / Q000378:metabolism*; D018406:Virus Physiological Phenomena
D008565:Membrane Proteins; D019707:Receptors, Chemokine; D043562:Receptors, G-Protein-Coupled; D014764:Viral Proteins