A synthetic receptor for nicotine from a dynamic combinatorial library.
Designing synthetic receptors that bind biologically relevant guests in an aqueous solution remains a considerable challenge. We now report a new synthetic receptor for nicotine, selected from a dynamic combinatorial library, that binds this guest in water at neutral pH through a combination of hydrophobic and π-π interactions.
Centre for Systems Chemistry, Stratingh Institute, University of Groningen, Nijenborgh 4, 9747 AG Groningen, The Netherlands.
Saleh
S
Hamieh
R Frederick
RF
Ludlow
Olivier
O
Perraud
Kevin R
KR
West
Elio
E
Mattia
Sijbren
S
Otto
D020650:Combinatorial Chemistry Techniques; D006863:Hydrogen-Ion Concentration; D015394:Molecular Structure; D009538:Nicotine / Q000737:chemistry*; D019906:Nuclear Magnetic Resonance, Biomolecular; D013816:Thermodynamics
D009538:Nicotine