Emphysema diagnosis using X-ray dark-field imaging at a laser-driven compact synchrotron light source.
In early stages of various pulmonary diseases, such as emphysema and fibrosis, the change in X-ray attenuation is not detectable with absorption-based radiography. To monitor the morphological changes that the alveoli network undergoes in the progression of these diseases, we propose using the dark-field signal, which is related to small-angle scattering in the sample. Combined with the absorption-based image, the dark-field signal enables better discrimination between healthy and emphysematous lung tissue in a mouse model. All measurements have been performed at 36 keV using a monochromatic laser-driven miniature synchrotron X-ray source (Compact Light Source). In this paper we present grating-based dark-field images of emphysematous vs. healthy lung tissue, where the strong dependence of the dark-field signal on mean alveolar size leads to improved diagnosis of emphysema in lung radiographs.
Department of Physics and Institute of Medical Engineering, Technische Universität München, 85748 Garching, Germany. schleede@tum.de
Simone
S
Schleede
Felix G
FG
Meinel
Martin
M
Bech
Julia
J
Herzen
Klaus
K
Achterhold
Guillaume
G
Potdevin
Andreas
A
Malecki
Silvia
S
Adam-Neumair
Sven F
SF
Thieme
Fabian
F
Bamberg
Konstantin
K
Nikolaou
Alexander
A
Bohla
Ali Ö
AÖ
Yildirim
Roderick
R
Loewen
Martin
M
Gifford
Ronald
R
Ruth
Oliver
O
Eickelberg
Maximilian
M
Reiser
Franz
F
Pfeiffer
D000818:Animals; D004646:Emphysema / Q000175:diagnosis*; D005260:Female; D007834:Lasers; D051379:Mice; D008810:Mice, Inbred C57BL; D017356:Synchrotrons; D014965:X-Rays