Secondary infertility due to use of low-dose finasteride.
Herein, we present an unusual case of secondary infertility after prolonged use of low-dose finasteride for androgenetic alopecia in a 40-year-old man. We detected sperm DNA damage in the patient. Despite such a long-term use, we observed that impairment in semen parameters and sperm DNA fragmentation index regressed after the drug was discontinued. Consequently, pregnancy occurred and resulted in live birth.
Department of Urology, Faculty of Medicine, Rumi University, Aksinne Mah, Esmetaş Sok, No: 16, 42040 Meram, Konya, Turkey. drsalvarci@hotmail.com
Ahmet
A
Şalvarci
Okan
O
Istanbulluoğlu
D058891:5-alpha Reductase Inhibitors / Q000009:adverse effects* / Q000627:therapeutic use; D000328:Adult; D000505:Alopecia / Q000188:drug therapy; D004249:DNA Damage / Q000187:drug effects; D018120:Finasteride / Q000009:adverse effects* / Q000627:therapeutic use; D006801:Humans; D007248:Infertility, Male / Q000139:chemically induced*; D008297:Male; D055101:Semen Analysis; D013094:Spermatozoa / Q000187:drug effects
D058891:5-alpha Reductase Inhibitors; D018120:Finasteride