[Relation between clinical-biological aspects and CD4 lymphocyte count in HIV/AIDS patients with non-tuberculous bronchopulmonary infection].
Pulmonary complications in HIV infection are still an important cause of morbidity and mortality among AIDS patients. An accurate assessment and diagnosis of these patients should include demografic, clinical, and laboratory data associated to the recognition of imaging pattern. When the radiological appearance is atypical and does not suggest pneumonia, the need of interpreting the pulmonary image in relation with HIV viremia level and CD4 lymphocyte count.


OBJECTIVE
Analysis of statistical data, diagnosis, course, and particularities of HIV/AIDS cases with non-tuberculous bronchopulmonary infections, and the possible relations between the pulmonary radiological appearance, viremia, and CD4 lymphocyte count.


METHODS
Retrospective clinical study of 121 patients with HIV infection and infectious pulmonary disease from Moldova (Romania) diagnosed and treated at HIV-AIDS Regional Centre of the lasi Clinical Hospital of Infectious Diseases. These patients were followed up in the interval January-December 2011. The studied demographic parameters were: age, gender, area of residence, years of disease. The clinical, laboratory, imaging (pulmonary Xray) data and CD4 lymphocyte count were analysed in dynamics. Data were processed statistically, a direct relation between clinical course and prognosis being found. Patients history, epidemiological history, respiratory symptoms (cough, thoracic pain, dyspnea) associated to the polimorphous clinical picture of HIV infection and the presence of associated comorbidities were recorded. The disease forms found were: lobar pneumonia, acute tracheobronchitis, interstitial pneumonia (non-tuberculous), and bronchopneumonia


CONCLUSIONS
Non-tuberculous bronchopulmonary infectious diseases accounted for a small percentage (13.5%) of the respiratory diseases in HIV/AIDS patients; most infections were found in patients with a CD4 lymphocyte count exceeding 300/mmc; of the clinical forms, acute tracheobronchitis and interstitial pneumonia were the most common; etiological treatment and favorable clinical-biological course were similar to immunocompetent hosts; pneumococci involved in the etiology of bacterial pneumonia in HIV/AIDS patients preserve the same sensitivity as in the seronegative patients.
Facultatea de Medicină, Universităţii de Medicină şi Farmacie "Grigore T. Popa"--Iaşi.
V
V
Mănucă
Carmen
C
Dorobăţ
D017088:AIDS-Related Opportunistic Infections / Q000175:diagnosis* / Q000276:immunology / Q000382:microbiology*; D000293:Adolescent; D000328:Adult; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D001991:Bronchitis / Q000175:diagnosis* / Q000276:immunology / Q000382:microbiology*; D018791:CD4 Lymphocyte Count; D002648:Child; D002675:Child, Preschool; D015897:Comorbidity; D003937:Diagnosis, Differential; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D016867:Immunocompromised Host; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D008875:Middle Aged; D011014:Pneumonia / Q000175:diagnosis* / Q000276:immunology / Q000382:microbiology*; D011237:Predictive Value of Tests; D011379:Prognosis; D012189:Retrospective Studies; D012383:Romania / Q000453:epidemiology; D012680:Sensitivity and Specificity; D014397:Tuberculosis, Pulmonary / Q000175:diagnosis / Q000453:epidemiology; D014766:Viremia / Q000175:diagnosis / Q000276:immunology
D000900:Anti-Bacterial Agents