Novel zierane- and guaiane-type sesquiterpenes from the root of Melicope denhamii.
Two novel zierane-type sesquiterpenes, named melicodenones A and B (1 and 2, resp.), and three new guaiane-type sesquiterpenes, named melicodenones C-E (3-5), were isolated from the root of Melicope denhamii (Seem.) T. G. Hartley together with zierone (6). Their structures were established by extensive NMR-spectroscopic analyses. Compounds 1-6 were tested for cytotoxicity using human colon cancer DLD-1 cells, and melicodenone A (1) was found to exhibit moderate activity.
Laboratory of Pharmacognosy, Gifu Pharmaceutical University, 1-25-4 Daigaku-nishi, Gifu 501 - 1196, Japan.
Ken-ichi
K
Nakashima
Masayoshi
M
Oyama
Tetsuro
T
Ito
Joko Ridho
JR
Witono
Dedy
D
Darnaedi
Toshiyuki
T
Tanaka
Jin
J
Murata
Munekazu
M
Iinuma
D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D008968:Molecular Conformation; D018517:Plant Roots / Q000737:chemistry; D027821:Rutaceae / Q000737:chemistry*; D012717:Sesquiterpenes / Q000737:chemistry* / Q000302:isolation & purification / Q000633:toxicity; D045789:Sesquiterpenes, Guaiane / Q000737:chemistry*
D012717:Sesquiterpenes; D045789:Sesquiterpenes, Guaiane; C421026:guaiane