[Analysis of risk factors in development of thrombosis in patients with antiphospholipid syndrome].
OBJECTIVE
To analyze the risk factors in the development of thrombosis in antiphospholipid syndrome (APS)  patients.


METHODS
We retrospectively analyzed the characteristics of thrombosis in 61 APS patients. Clinical and laboratory  parameters such as sex, age, thrombocytopenia, smoking, hypertension, diabetes mellitus, hyperlipidemia and anti-phospholipid  antibodies were investigated to find out the risk factors of thrombosis.


RESULTS
Thrombosis was found in 70.49% APS  patients, of whom, the prevalence of arterial and venous thrombosis were 36.67% and 39.34%, respectively. Deep vein thrombosis of  lower extremity (37.7%) and cerebral infarction (24.59%) were the most common thrombosis events, and then pulmonary embolism,  thrombotic microangiopathy and renal artery thrombosis were also common in APS patients. The positive anti-cardiolipin antibody  and hypertension were the independent risk factors for venous and arterial thrombosis, respectively.


CONCLUSIONS
Anti-cardiolipin antibody is associated with a higher risk of venous thrombosis, and hypertension is associated with arterial thrombosis.
Department of Rheumatology and Immunology, Peking University People's Hospital, Beijing, China.
Ru
R
Li
Yun-shan
YS
Zhou
Yuan
Y
Jia
Zhan-guo
ZG
Li
D000293:Adolescent; D000328:Adult; D000368:Aged; D017153:Antibodies, Anticardiolipin / Q000097:blood; D016736:Antiphospholipid Syndrome / Q000150:complications*; D002544:Cerebral Infarction / Q000453:epidemiology / Q000209:etiology; D002681:China / Q000453:epidemiology; D005260:Female; D006801:Humans; D006973:Hypertension / Q000150:complications; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D012307:Risk Factors; D013927:Thrombosis / Q000453:epidemiology* / Q000209:etiology*; D020246:Venous Thrombosis / Q000453:epidemiology / Q000209:etiology; D055815:Young Adult
D017153:Antibodies, Anticardiolipin