Functional annotation of genes differentially expressed between primary motor and prefrontal association cortices of macaque brain.
DNA microarray-based genome-wide transcriptional profiling and gene network analyses were used to characterize the molecular underpinnings of the neocortical organization in rhesus macaque, with particular focus on the differences in the functional annotation of genes in the primary motor cortex (M1) and the prefrontal association cortex (area 46 of Brodmann). Functional annotation of the differentially expressed genes showed that the list of genes selectively expressed in M1 was enriched with genes involved in oligodendrocyte function, and energy consumption. The annotation appears to have successfully extracted the characteristics of the molecular structure of M1.
Research Equipment Center, Hamamatsu University School of Medicine, Hamamatsu, Shizuoka 431-3192, Japan. tkojima@hama-med.ac.jp
Toshio
T
Kojima
Noriyuki
N
Higo
Akira
A
Sato
Takao
T
Oishi
Yukio
Y
Nishimura
Tatsuya
T
Yamamoto
Yumi
Y
Murata
Kimika
K
Yoshino-Saito
Hirotaka
H
Onoe
Tadashi
T
Isa
D000818:Animals; D004734:Energy Metabolism / Q000235:genetics; D005786:Gene Expression Regulation / Q000502:physiology*; D053263:Gene Regulatory Networks / Q000235:genetics; D055106:Genome-Wide Association Study; D008253:Macaca mulatta; D046228:Microarray Analysis; D009044:Motor Cortex / Q000378:metabolism*; D009836:Oligodendroglia / Q000502:physiology; D017397:Prefrontal Cortex / Q000378:metabolism*; D012313:RNA / Q000096:biosynthesis / Q000302:isolation & purification
D012313:RNA