Ruthenium- and rhodium-catalyzed cross-coupling reaction of acrylamides with alkenes: efficient access to (Z,E)-dienamides.
Ruthenium- and rhodium-catalyzed direct oxidative cross-coupling reactions of acrylamides with alkenes were developed. These methods provide an efficient route for the synthesis of (Z,E)-dienamides in excellent yields with good stereoselectivity. The catalytic systems allowed oxidative olefination of a wide range of alkenes bearing different functional groups, such as CO(2)R, COMe, SO(2)Ph, aryl, CONHBn, CN, PO(OEt)(2), as well as Weinreb amide.
Division of Chemistry and Biological Chemistry, School of Physical and Mathematical Sciences, Nanyang Technological University, Singapore, 637616.
Jian
J
Zhang
Teck-Peng
TP
Loh
D000178:Acrylamides / Q000737:chemistry*; D000475:Alkenes / Q000737:chemistry*; D000577:Amides / Q000737:chemistry*; D002384:Catalysis; D010084:Oxidation-Reduction; D012238:Rhodium / Q000737:chemistry*; D012428:Ruthenium / Q000737:chemistry*; D013237:Stereoisomerism
D000178:Acrylamides; D000475:Alkenes; D000577:Amides; D012428:Ruthenium; D012238:Rhodium