Exceptional simian hemorrhagic fever virus diversity in a wild African primate community.
Simian hemorrhagic fever virus (SHFV) is an arterivirus that causes severe disease in captive macaques. We describe two new SHFV variants subclinically infecting wild African red-tailed guenons (Cercopithecus ascanius). Both variants are highly divergent from the prototype virus and variants infecting sympatric red colobus (Procolobus rufomitratus). All known SHFV variants are monophyletic and share three open reading frames not present in other arteriviruses. Our data suggest a need to modify the current arterivirus classification.
Department of Pathology and Laboratory Medicine, University of Wisconsin-Madison, Madison, Wisconsin, USA.
Michael
M
Lauck
Samuel D
SD
Sibley
David
D
Hyeroba
Alex
A
Tumukunde
Geoffrey
G
Weny
Colin A
CA
Chapman
Nelson
N
Ting
William M
WM
Switzer
Jens H
JH
Kuhn
Thomas C
TC
Friedrich
David H
DH
O'Connor
Tony L
TL
Goldberg
D000349:Africa; D000818:Animals; D018018:Arterivirus / Q000145:classification* / Q000235:genetics / Q000302:isolation & purification*; D018174:Arterivirus Infections / Q000662:veterinary* / Q000821:virology; D058345:Asymptomatic Infections; D002521:Cercopithecus; D016000:Cluster Analysis; D014644:Genetic Variation; D005838:Genotype; D008969:Molecular Sequence Data; D010802:Phylogeny; D018419:Primate Diseases / Q000821:virology*; D012367:RNA, Viral / Q000235:genetics*; D017422:Sequence Analysis, DNA
D012367:RNA, Viral