[Regenerative medicine using cell-sheet engineering].
We have developed a novel strategy for regenerative medicine to recover tissue functions using temperature-responsive cell culture surfaces. To overcome the disadvantages of conventional methods such as the usage of single-cell suspension injections and biodegradable polymer scaffolds, we use transplantable cell sheets fabricated with temperature-responsive culture surfaces for cell delivery. Here, we summarize our progress in promoting regenerative medicine using cell-sheet engineering with respect to research and regulatory systems and describe recent challenges in the standardization of cell-sheet engineering.
Institute of Advanced Biomedical Engineering and Science, Tokyo Women's Medical University (TWIns), Tokyo, Japan.
Nobuo
N
Kanai
Masayuki
M
Yamato
Takeshi
T
Ohki
Masakazu
M
Yamamoto
Teruo
T
Okano
D060846:Cell Engineering / Q000379:methods*; D006801:Humans; D044968:Regenerative Medicine / Q000379:methods*