Formulation and characterization of Cefuroxime Axetil nanoemulsion for improved bioavailability.
Cefuroxime Axetil nanoemulsion was formulated to address the problem of poor oral bioavailability. Formulation was manufactured utilizing Capmul MCM, Soya lecithin, Deoxycholic acid, Pluronic F127 and distilled water. Mean globular size of 121.3 nm was obtained. Drug content of nanoemulsion was found to be 97.12±0.27%(w)/(v). 80.7261% of the drug was diffused from nanoemulsion, as compared with 51.0048% diffused from the plain Cefuroxime axetil suspension. In vivo studies indicated AUC(0-24): 325.3 for nanoemulsion in comparison to AUC(0-24): 165.3 for plain suspension. Therefore a good orally bioavailable formulation was developed successfully.
Centre for PG Studies and Research, TIFAC CORE in NDDS, Department of Pharmacy, The M.S. University of Baroda, Vadodara, Gujarat, India.
Yomesh
Y
Patel
Aditi
A
Poddar
Krutika
K
Sawant