New alkaloids and cytotoxic principles from Sinomenium acutum.
Two new alkaloids, 2-demethyl-oxypalmatine (1) and 5-ethoxycarbonylsinoracutine (2), were isolated from the rhizomes of Sinomenium acutum, along with thirty-four known compounds. Cytotoxicity of the isolated compounds was examined for the MCF-7, H460, HT-29, and CEM human cancer cell lines. Dauriporphine (16), 6-O-demethylmenisporphine (17), bianfugecine (18), menisporphine (19), and 6-O-demethyldauriporphine (20) showed differential effects in their cytotoxic activity on the target cancer cell lines. Significant angiogenesis inhibitions of 16 and 19 were also observed.
National Research Institute of Chinese Medicine, Taipei, Taiwan.
Jing-Jy
JJ
Cheng
Tung-Hu
TH
Tsai
Lie-Chwen
LC
Lin
D000470:Alkaloids / Q000302:isolation & purification / Q000494:pharmacology; D043925:Angiogenesis Inducing Agents / Q000032:analysis / Q000737:chemistry / Q000494:pharmacology; D000972:Antineoplastic Agents, Phytogenic / Q000032:analysis* / Q000737:chemistry / Q000494:pharmacology*; D003603:Cytotoxins / Q000302:isolation & purification / Q000494:pharmacology; D004365:Drugs, Chinese Herbal / Q000032:analysis / Q000737:chemistry / Q000494:pharmacology*; D006367:HeLa Cells; D006801:Humans; D015394:Molecular Structure; D009369:Neoplasms / Q000188:drug therapy*; D027343:Rhizome / Q000737:chemistry; D032841:Sinomenium / Q000737:chemistry*
D000470:Alkaloids; D043925:Angiogenesis Inducing Agents; D000972:Antineoplastic Agents, Phytogenic; D003603:Cytotoxins; D004365:Drugs, Chinese Herbal