Rilonacept for colchicine-resistant or -intolerant familial Mediterranean fever: a randomized trial.
BACKGROUND
Currently, there is no proven alternative therapy for patients with familial Mediterranean fever (FMF) that is resistant to or intolerant of colchicine. Interleukin-1 is a key proinflammatory cytokine in FMF.


OBJECTIVE
To assess the efficacy and safety of rilonacept, an interleukin-1 decoy receptor, in treating patients with colchicine-resistant or -intolerant FMF.


METHODS
Randomized, double-blind, single-participant alternating treatment study. (ClinicalTrials.gov number: NCT00582907).


METHODS
6 U.S. sites.


METHODS
Patients with FMF aged 4 years or older with 1 or more attacks per month.


METHODS
One of 4 treatment sequences that each included two 3-month courses of rilonacept, 2.2 mg/kg (maximum, 160 mg) by weekly subcutaneous injection, and two 3-month courses of placebo.


METHODS
Differences in the frequency of FMF attacks and adverse events between rilonacept and placebo.


RESULTS
8 males and 6 females with a mean age of 24.4 years (SD, 11.8) were randomly assigned. Among 12 participants who completed 2 or more treatment courses, the rilonacept-placebo attack risk ratio was 0.59 (SD, 0.12) (equal-tail 95% credible interval, 0.39 to 0.85). The median number of attacks per month was 0.77 (0.18 and 1.20 attacks in the first and third quartiles, respectively) with rilonacept versus 2.00 (0.90 and 2.40, respectively) with placebo (median difference, -1.74 [95% CI, -3.4 to -0.1]; P = 0.027). There were more treatment courses of rilonacept without attacks (29% vs. 0%; P = 0.004) and with a decrease in attacks of greater than 50% compared with the baseline rate during screening (75% vs. 35%; P = 0.006) than with placebo. However, the duration of attacks did not differ between placebo and rilonacept (median difference, 1.2 days [-0.5 and 2.4 days in the first and third quartiles, respectively]; P = 0.32). Injection site reactions were more frequent with rilonacept (median difference, 0 events per patient treatment month [medians of -4 and 0 in the first and third quartiles, respectively]; P = 0.047), but no differences were seen in other adverse events.


CONCLUSIONS
Small sample size, heterogeneity of FMF mutations, age, and participant indication (colchicine resistance or intolerance) were study limitations.


CONCLUSIONS
Rilonacept reduces the frequency of FMF attacks and seems to be a treatment option for patients with colchicine-resistant or -intolerant FMF.


BACKGROUND
U.S. Food and Drug Administration, Office of Orphan Products Development.
Pediatric Rheumatology Unit, Shaare Zedek Medical Center, POB 3235, Jerusalem, 91031 Israel. hashkesp@szmc.org.il
Philip J
PJ
Hashkes
Steven J
SJ
Spalding
Edward H
EH
Giannini
Bin
B
Huang
Anne
A
Johnson
Grace
G
Park
Karyl S
KS
Barron
Michael H
MH
Weisman
Noune
N
Pashinian
Andreas O
AO
Reiff
Jonathan
J
Samuels
Dowain A
DA
Wright
Daniel L
DL
Kastner
Daniel J
DJ
Lovell
D000293:Adolescent; D000328:Adult; D002648:Child; D002675:Child, Preschool; D003078:Colchicine / Q000009:adverse effects / Q000627:therapeutic use; D004311:Double-Blind Method; D004351:Drug Resistance; D010505:Familial Mediterranean Fever / Q000188:drug therapy*; D005260:Female; D006801:Humans; D008297:Male; D053573:Receptors, Interleukin-1 Type I / Q000627:therapeutic use*; D011993:Recombinant Fusion Proteins / Q000009:adverse effects / Q000627:therapeutic use*; D016896:Treatment Outcome; D055815:Young Adult
D053573:Receptors, Interleukin-1 Type I; D011993:Recombinant Fusion Proteins; C531377:rilonacept; D003078:Colchicine