Association between biomarkers of obesity and risk of high-grade prostatic intraepithelial neoplasia and prostate cancer--evidence of effect modification by prostate size.
Prostate enlargement is common with aging and obesity. We investigated the association between obesity and prostate cancer controlling for differential detection related to prostate enlargement. In an analysis of 500 men, we found body mass index, waist-hip ratio, and blood leptin levels were significantly associated with high-grade PC, but only among men without prostate enlargement. Leptin was also significantly associated with high-grade prostatic intraepithelial neoplasia (HGPIN) in the absence of prostate enlargement. Our results suggest obesity advances prostate carcinogenesis, and that detection biases at prostate biopsy may explain past inconsistencies in the association between obesity and PC.
Vanderbilt University Medical Center, Division of Epidemiology, Nashville, TN 37203, United States. jay.fowke@vanderbilt.edu
Jay H
JH
Fowke
Saundra
S
Motley
Qi
Q
Dai
Raoul
R
Concepcion
Daniel A
DA
Barocas
D000368:Aged; D015415:Biomarkers; D001706:Biopsy; D001837:Body Weights and Measures; D006801:Humans; D008297:Male; D008875:Middle Aged; D060787:Neoplasm Grading; D009765:Obesity / Q000097:blood* / Q000150:complications; D009929:Organ Size; D011467:Prostate / Q000473:pathology*; D019048:Prostatic Intraepithelial Neoplasia / Q000097:blood* / Q000150:complications / Q000473:pathology*; D011471:Prostatic Neoplasms / Q000097:blood* / Q000150:complications / Q000473:pathology*; D012306:Risk
D015415:Biomarkers