Postprandial blood glucose response to grape seed extract in healthy participants: A pilot study.
BACKGROUND
The consumption of a high carbohydrate diet may be associated with an increased risk of type 2 diabetes and obesity. Previous studies in vitro have revealed that grape seed extract (GSE) inhibited the intestinal α-glucosidases and α-pancreatic amylase that may delay carbohydrate digestion and absorption, resulting in the suppression of postprandial glycemia. The objective of the study was to assess whether consumption of GSE together with high carbohydrate meal affects postprandial glycemia in healthy participants.


METHODS
The study used acute, randomized, controlled crossover design in which eight healthy subjects (four female and four male, mean aged 21.25 ± 3.69 years; body mass index =20.28 ± 1.40 kg/m(2)) received high carbohydrate (HC) meal (73.6 %) together with or without 100 and 300 mg GSE.


RESULTS
Results showed that postprandial plasma glucose concentrations at 15 min and 30 min after ingestion HC meal together with 100 mg GSE (5.33 ± 0.41 mmol/L and 5.62 ± 0.47 mmol/L, respectively) and 300 mg GSE (5.27 ± 0.29 mmol/L; 5.75 ± 0.44 mmol/L, respectively) were significantly lower than that of HC meal (P<0.05). There was statistically significant difference in the 2 h area under the glucose response curve between HC meal and HC meal plus GSE.


CONCLUSIONS
GSE reduces postprandial plasma glucose in healthy participants. The delayed and attenuated hyperglycemia may have a useful strategy to prevent development of diabetes in the healthy population.
The Medical Food Research and Development Center, Department of Nutrition and Dietetics, Faculty of Allied Health Science, Chulalongkorn University, Bangkok, Thailand ; Research Group of Herbal Medicine for Prevention and Therapeutic of Metabolic diseases, Chulalongkorn University, Bangkok, Thailand.
Suwimol
S
Sapwarobol
Sirichai
S
Adisakwattana
Sawitree
S
Changpeng
Wilwan
W
Ratanawachirin
Kanokporn
K
Tanruttanawong
Waridtha
W
Boonyarit