Insights into tuberculosis from the zebrafish model.
Mycobacterium tuberculosis (MTB) continues to plague humanity because of significant gaps in our understanding of MTB infection, including the nature of a protective versus pathological host response, why antimicrobial cure is so difficult, and the ineffectiveness of vaccination. The development of a zebrafish model, utilizing infection with the natural fish pathogen Mycobacterium marinum (Mm), has yielded important insights into tuberculosis with immediate clinical applications.
Department of Molecular and Cell Biology, University of Washington, Seattle, WA 98195, USA.
Russell D
RD
Berg
Lalita
L
Ramakrishnan
D000818:Animals; D004195:Disease Models, Animal; D006099:Granuloma / Q000473:pathology; D019910:Mycobacterium marinum; D014376:Tuberculosis / Q000503:physiopathology*; D015027:Zebrafish