Pyridine synthesis by reactions of allyl amines and alkynes proceeding through a Cu(OAc)2 oxidation and Rh(III)-catalyzed N-annulation sequence.
A new methodology has been developed for the synthesis of pyridines from allyl amines and alkynes, which involves sequential Cu(II)-promoted dehydrogenation of the allylamine and Rh(III)-catalyzed N-annulation of the resulting α,β-unsaturated imine and alkyne.
Department of Chemistry, Yonsei University, 50 Yonseiro, Seodaemun-gu, Seoul 120-749, Korea.
Dong-Su
DS
Kim
Jung-Woo
JW
Park
Chul-Ho
CH
Jun
D000085:Acetates / Q000737:chemistry*; D000480:Alkynes / Q000737:chemistry*; D000588:Amines / Q000737:chemistry*; D002384:Catalysis; D003300:Copper / Q000737:chemistry*; D003500:Cyclization; D010084:Oxidation-Reduction; D011725:Pyridines / Q000138:chemical synthesis / Q000737:chemistry*; D012238:Rhodium / Q000737:chemistry*
D000085:Acetates; D000480:Alkynes; D000588:Amines; D011725:Pyridines; D003300:Copper; D012238:Rhodium; C023666:pyridine