Radiation-induced osteosarcoma of the larynx: case report and literature review.
Laryngeal osteosarcoma is an extremely rare disease. Only 23 cases have been published in the literature. Radiation-induced laryngeal osteosarcoma is even rarer; this is only the third such case to be reported. A 59-year-old man underwent radiotherapy for an in situ laryngeal squamous cell carcinoma at another institution. Five years later he developed a laryngeal osteosarcoma, and a total laryngectomy was performed. Although previous reports showed a poor prognosis, our patient was without disease at the 8-year follow-up. To the best of our knowledge, this is the longest disease-free follow-up to be reported in the literature. We also present a review of the world's literature.
Department of Otorhinolaryngology, Diyarbakir Research and Training Hospital, Diyarbakir, Turkey 21070. muratulusan@hotmail.com
Murat
M
Ulusan
Rasim
R
Yilmazer
Yasemin
Y
Ozluk
Murat
M
Enoz
Yusufhan
Y
Suoglu
D002294:Carcinoma, Squamous Cell / Q000532:radiotherapy*; D006801:Humans; D007822:Laryngeal Neoplasms / Q000175:diagnosis* / Q000209:etiology* / Q000628:therapy; D008297:Male; D008875:Middle Aged; D009381:Neoplasms, Radiation-Induced / Q000175:diagnosis* / Q000209:etiology / Q000628:therapy; D012516:Osteosarcoma / Q000175:diagnosis* / Q000209:etiology* / Q000628:therapy