[Effect of selenium on serum TGAb, TMAb, FT3, FT4 and TSH of rats with excessive intake of iodine].
OBJECTIVE
To investigate the effect of selenium on the TGAb, TMAb, FT3, FT4 and TSH level of rats with excessive intake of iodine.


METHODS
Wistar rats were divided into three groups by random:normal control, high iodine group and high iodine plus selenium group. Rats in the high iodine plus selenium group were lavaged with sodium selenite for 10 weeks. The levels of serum TGAb, TMAb, FT3, FT4 and TSH were tested at different time of the experiment.


RESULTS
There were no significant change on levels of FT3, FT4 and TSH (P > 0.05). The levels of TGAb and TMAb in the high iodine group were increased slowly (P < 0.05), but no significant change was observed in the high iodine plus selenium group.


CONCLUSIONS
Excessive intake of iodine might induce goiter, and selenium might have antagonistic effect on it.
Department of Endocrinology, Weihai Municipal Hospital, Weihai 264200, China. zhaoweichihaiyan@163.com
Haiyan
H
Chi
Yuping
Y
Zhou
Li
L
Li
D000818:Animals; D006042:Goiter / Q000209:etiology / Q000517:prevention & control; D007454:Iodides; D007455:Iodine / Q000009:adverse effects; D051381:Rats; D017208:Rats, Wistar; D012643:Selenium / Q000494:pharmacology*; D018036:Selenium Compounds; D013963:Thyroid Hormones / Q000378:metabolism*; D013972:Thyrotropin / Q000187:drug effects; D014284:Triiodothyronine / Q000187:drug effects
D007454:Iodides; D018036:Selenium Compounds; D013963:Thyroid Hormones; D014284:Triiodothyronine; D013972:Thyrotropin; D007455:Iodine; D012643:Selenium