DD genotype of ACE gene I/D polymorphism is associated with Behcet disease in a Turkish population.
Behcet's disease (BD) is a chronic, multi-systemic and inflammatory disorder. The local renin-angiotensin system (RAS) in the vessel wall plays a role in the endothelial control and contributes to inflammatory processes. Angiotensin-converting enzyme (ACE) is the regulatory component of the RAS. This study was conducted in Turkish patients with BD to determine the frequency of I/D polymorphism genotypes of ACE gene. Genomic DNA obtained from 566 persons (266 patients with BD and 300 healthy controls). ACE gene I/D polymorphism genotypes were determined using polymerase chain reaction using I and D allele-specific primers. There was statistically significant difference between the groups with respect to genotype distribution (p < 0.001). This study is the largest study in Turkish population that ACE gene I/D polymorphism investigated in BD. As a result of this study, ACE gene I/D polymorphism DD genotype could be a genetic marker in BD in Turkish study population.
Department of Medical Biology, Faculty of Medicine, Gaziosmapaşa University, Tokat, Turkey. serbulent.yigit@gmail.com
Serbülent
S
Yigit
Sengül
S
Tural
Aydin
A
Rüstemoglu
Ahmet
A
Inanir
Ulker
U
Gul
Goknur
G
Kalkan
Songul
S
Akkanet
Nevin
N
Karakuş
Omer
O
Ateş
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001528:Behcet Syndrome / Q000235:genetics*; D016022:Case-Control Studies; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D007703:Peptidyl-Dipeptidase A / Q000235:genetics*; D011110:Polymorphism, Genetic; D014421:Turkey; D055815:Young Adult
C488034:ACE protein, human; D007703:Peptidyl-Dipeptidase A