Three-grade classification of photoplethysmography for evaluating the effects of treatment in Raynaud phenomenon.
We assessed the utility of a 3-grade classification of photoplethysmography (PPG) with cold water provocation test in Raynaud phenomenon (RP). A total of 35 patients with RP and 38 healthy volunteers were recruited. In healthy volunteers, PPG was measured twice at intervals of 30 minutes for evaluating reproducibility of test. Percentage variation of the PPG amplitude in post- versus precold provocation was expressed on a 3-grade scale at 1, 3, and 5 minutes (reflection index: RI) in patients with RP. The improvement pattern of the PPG (IPPPG) was evaluated by summing the score differences from RI1 min to RI3 min and RI5 min. After a therapeutic period of 8 weeks with nifedipine, the decreases in posttherapeutic RI3 min and RI5 min were statistically significant (P < .05). Subgroup analysis of IPPPG showed statistical significance in patients with negative fluorescent antinuclear antibody (P < .05). The analysis of cold-provoked PPG waves demonstrated and quantified improvements in peripheral arterial circulation in RP.
1Department of Surgery, Division of Vascular Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
Shin-Seok
SS
Yang
Keun-Myoung
KM
Park
Young-Wook
YW
Kim
Dong-Ik
DI
Kim
D000328:Adult; D000368:Aged; D000974:Antibodies, Antinuclear; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D008991:Monitoring, Physiologic; D017156:Photoplethysmography / Q000145:classification*; D011928:Raynaud Disease / Q000175:diagnosis / Q000503:physiopathology / Q000628:therapy*; D015203:Reproducibility of Results; D055815:Young Adult
D000974:Antibodies, Antinuclear