[Intracranial, cerebral perfusion pressure and systemic hemodynamic parameters during anesthesia induction in patients with traumatic brain compression].
The study reports the dynamic of ICP, CPP and systemic hemodynamic rates during midazolam induction of anesthesia in patients with traumatic brain compression. Patients who need urgent surgery to eliminate brain compression of various degrees generally have intracranial hypertension. Midazolam administration decreases ICP by 22% from baseline under condition of stable hemodynamic and CPP. Depolarizing neuromuscular blocking agents' administration, mechanical ventilation and tracheal intubation lead to ICP elevation and CPP decreasing. The combination of midazolam and fentanil provides more reliable protection from hypertensive reactions.
D000328:Adult; D000758:Anesthesia / Q000009:adverse effects / Q000379:methods*; D018686:Anesthetics, Intravenous / Q000008:administration & dosage / Q000009:adverse effects; D001930:Brain Injuries / Q000503:physiopathology / Q000601:surgery*; D004359:Drug Therapy, Combination; D005260:Female; D005283:Fentanyl / Q000008:administration & dosage / Q000009:adverse effects; D006439:Hemodynamics; D006801:Humans; D019586:Intracranial Hypertension / Q000209:etiology*; D007427:Intracranial Pressure; D007442:Intubation, Intratracheal / Q000009:adverse effects / Q000379:methods; D008297:Male; D008874:Midazolam / Q000008:administration & dosage / Q000009:adverse effects; D008875:Middle Aged; D009467:Neuromuscular Depolarizing Agents / Q000008:administration & dosage / Q000009:adverse effects; D012121:Respiration, Artificial / Q000009:adverse effects / Q000379:methods
D018686:Anesthetics, Intravenous; D009467:Neuromuscular Depolarizing Agents; D008874:Midazolam; D005283:Fentanyl