Mechanisms of dorsoventral axis formation and its clinical implications.
Dorsal-ventral axis formation is one of the earliest and the most important steps of patterning formation during early  embryogenesis. The molecular basis of dorsoventral axis formation reflects the fundamental issues of orchestrated cell proliferation  and differentiation. Wildly speculated since the Renaissance, the effort of deciphering the mechanisms of Dorsal-ventral axis  formation has contributed significantly to our current understanding of disease pathogenesis. Here, we focused our discussion on the  recent discovery of the convergence of dorsal and ventral signaling pathways during early embryogenesis and its implications in  cancer biology and beyond.
Department of Medicine, Harvard Medical School, Boston, MA 02115, USA.
Hong
H
Gao
Zheng lun
Zl
Zhu
D000818:Animals; D019521:Body Patterning; D047108:Embryonic Development / Q000235:genetics / Q000502:physiology; D018507:Gene Expression Regulation, Developmental; D006801:Humans; D007109:Immunity / Q000502:physiology; D009024:Morphogenesis / Q000235:genetics; D009369:Neoplasms / Q000503:physiopathology; D015398:Signal Transduction / Q000235:genetics