Cytogenetic findings in pediatric radiation-induced atypical meningioma after treatment of medulloblastoma: case report and review of the literature.
Ionizing radiation is the most recognized risk factor for meningioma in pediatric long-term cancer survivors. Information in this rare setting is exceptional. We report the clinical and cytogenetic findings in a radiation-induced atypical meningioma following treatment for desmoplastic medulloblastoma in a child. This is the second study to describe the cytogenetic aspects on radiation-induced meningiomas in children. Chromosome banding analysis revealed a 46, XX, t(1;3)(p22;q12), del(1)(p?)[8]/46, XX[12]. Loss of chromosome 1p as a consequence of irradiation has been proposed to be more important in the development of secondary meningiomas in adults. Deletions in the short arm of chromosome 1 also appear to be a shared feature in both pediatric cases so far analyzed.
Laboratório de Pediatria, Division of Pediatric Oncology, Department of Pediatrics, Hospital das Clínicas da Faculdade de Medicina de Ribeirão Preto, University of São Paulo, Bloco G. Av. Bandeirantes, Bairro Monte Alegre 3900, Ribeirão Prêto, SP, CEP 14048-900, Brazil. marsol@rge.fmrp.usp.br
María Sol
MS
Brassesco
Elvis Terci
ET
Valera
Luciano
L
Neder
Julia Alejandra
JA
Pezuk
Ricardo Santos
RS
Oliveira
Carlos Alberto
CA
Scrideli
Luiz Gonzaga
LG
Tone
D002528:Cerebellar Neoplasms / Q000150:complications / Q000473:pathology / Q000532:radiotherapy*; D002648:Child; D002675:Child, Preschool; D002869:Chromosome Aberrations; D002878:Chromosomes, Human, Pair 1 / Q000235:genetics*; D020732:Cytogenetic Analysis; D005260:Female; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D008527:Medulloblastoma / Q000150:complications / Q000473:pathology / Q000532:radiotherapy*; D008579:Meningioma / Q000209:etiology* / Q000473:pathology; D009381:Neoplasms, Radiation-Induced / Q000209:etiology* / Q000473:pathology; D011379:Prognosis; D011878:Radiotherapy / Q000009:adverse effects*; D012196:Review Literature as Topic