Dermatomyositis associated with HIV-1 infection in a Nigerian adult female: a case report.
Human immunodeficiency virus (HIV) infection has been implicated as a trigger for various autoimmune diseases, one of which is dermatomyositis. This is a very rare autoimmune disease characterised by myopathy, typical cutaneous signs and variable systemic manifestations. To our knowledge, the association of this rare disease with HIV infection has not been previously reported in Nigeria. We therefore decided to report the case of a 40 year old HIV-1 infected Nigerian female who presented to us with muscle, skin, and systemic manifestations of dermatomyositis. Our aim is to show the effect of HIV infection, as well as HAART-induced immune reconstitution on the clinical course of dermatomyositis.
Department of Medicine, Niger Delta University, Wilberforce Island, Amasomma, Bayelsa State, Nigeria. dimostic@yahoo.co.uk
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Ogoina
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Umar
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Obiako
D000328:Adult; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D023241:Antiretroviral Therapy, Highly Active / Q000009:adverse effects*; D001327:Autoimmune Diseases / Q000175:diagnosis* / Q000188:drug therapy / Q000209:etiology; D003882:Dermatomyositis / Q000175:diagnosis* / Q000188:drug therapy / Q000209:etiology; D004008:Diclofenac / Q000627:therapeutic use; D005260:Female; D015658:HIV Infections / Q000150:complications* / Q000188:drug therapy / Q000276:immunology; D015497:HIV-1; D006801:Humans; D054019:Immune Reconstitution Inflammatory Syndrome / Q000139:chemically induced*; D009549:Nigeria; D011239:Prednisolone / Q000627:therapeutic use; D016896:Treatment Outcome
D000893:Anti-Inflammatory Agents; D004008:Diclofenac; D011239:Prednisolone