A case series of lamotrigine increased to 300mg daily in patients with bipolar depression.
Bipolar depression is a condition lacking sufficient treatment options. While lamotrigine appears effective, clinical trials and prescribing guidelines address only daily doses below 300mg.


METHODS
Thirteen consecutive outpatients with bipolar depression and taking 200mg of daily lamotrigine were openly administered a dose increased to 300mg and naturalistically followed. Study outcome was assessed by comparison of pre- and post-treatment Beck Depression Inventory (BDI) and Global Assessment of Functioning (GAF) scores. Stastical analysis applied the paired t-test.


RESULTS
Increasing daily lamotrigine dose to 300mg was associated with good tolerability and significant improvement in BDI and GAF scores.
Nord Center, 6140 South Broadway, Lorain, Ohio, OH, USA.
Praveen Francis
PF
Abraham