Characterization of the osseointegration of Algipore and Algipore modified with mineralized collagen type I.
OBJECTIVE
Algipore is a clinically established bone substitute. The present study evaluated the osseoconductive and resorptive characteristics of Algipore modified with collagen type I (ACI).


METHODS
Three defects of 10 × 3 mm were set in the frontal bone of 10 adult female minipigs. One cavity was filled with commercially available Algipore, and the second with ACI. The third cavity was left unfilled and served as reference. After 4 months of healing, the animals were humanely killed. Bone formation and resorption characteristics of the substitutes were evaluated histomorphologically and histomorphometrically using Donath's sawing and grinding technique.


RESULTS
Neither material caused inflammatory reactions. Compared with controls, both substitutes showed significantly higher fractions of trabecular bone (control: 42.2%; Algipore: 58.7%, [P < .001]; ACI: 53.6%, [P = .013]). After 4 months, the remaining fraction of Algipore was 42.2% and the fraction of ACI was 47.9% (P = .016).


CONCLUSIONS
The present study demonstrates that the modification of Algipore with collagen I does not show any benefits compared with pure Algipore in small calvarial bone defects in minipigs.
Department of Oral and Maxillofacial Surgery, Faculty of Medicine "Carl Gustav Carus", Technische Universität, Dresden, Germany; Centre for Translational Bone, Joint and Soft Tissue Research, Faculty of Medicine "Carl Gustav Carus", Technische Universität, Dresden, Germany. matthias.schulz@uniklinikum-dresden.de
Matthias C
MC
Schulz
Anja
A
Lode
Sabine
S
Wittig
Bernd
B
Stadlinger
Eberhard
E
Kuhlisch
Uwe
U
Eckelt
Michael
M
Gelinsky
Ronald
R
Mai
D000818:Animals; D001862:Bone Resorption / Q000517:prevention & control*; D018786:Bone Substitutes / Q000737:chemistry*; D016025:Bone Transplantation / Q000379:methods*; D024042:Collagen Type I / Q000737:chemistry*; D005260:Female; D006652:Histological Techniques; D053761:Nanocomposites / Q000737:chemistry; D016348:Osseointegration / Q000502:physiology*; D010012:Osteogenesis / Q000502:physiology*; D013552:Swine
C483718:Algipore; D018786:Bone Substitutes; D024042:Collagen Type I