miR-499 rs3746444 polymorphism is associated with cancer development among Asians and related to breast cancer susceptibility.
To derive a more precise estimation of the relationship between miR-499 rs3746444 polymorphism (A>G) and cancer risk, a meta-analysis was performed. A total of 9 studies including 6,077 cases and 7,199 controls were involved in this meta-analysis. Overall, no significantly elevated cancer risk was associated with miR-499 G allele when all studies were pooled into the meta-analysis (AG vs. AA: OR = 1.14, 95 % CI = 0.98-1.32; GG vs. AA: OR = 1.12, 95 % CI = 0.95-1.33; dominant model: OR = 1.13, 95 % CI = 0.99-1.29; recessive model: OR = 1.05, 95 % CI = 0.83-1.33). In the subgroup analysis by ethnicity, significantly increased risk was only found for Asians (dominant model: OR = 1.22, 95 % CI = 1.02-1.46). When stratified by study design, no statistically significantly elevated risks were found in hospital-based studies or population-based studies. In the subgroup analysis by cancer type, significant cancer risk change was only found for breast cancer when miR-499 G allele was included (dominant model: OR = 1.13, 95 % CI = 1.01-1.26). In conclusion, this meta-analysis suggests that the miR-499 rs3746444 polymorphism (A>G) is a low-penetrant risk factor for cancer development among Asians and may contribute to breast cancer susceptibility.
Department of Medical Oncology, Fourth Affiliated Hospital of Nantong University, First People's Hospital of Yancheng, Yancheng, China. doc_pchen@126.com
Ping
P
Chen
Jian
J
Zhang
Feng
F
Zhou
D044466:Asian People / Q000235:genetics*; D001943:Breast Neoplasms / Q000235:genetics*; D002471:Cell Transformation, Neoplastic / Q000235:genetics*; D005260:Female; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006801:Humans; D035683:MicroRNAs / Q000235:genetics* / Q000378:metabolism; D016017:Odds Ratio; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D017594:Publication Bias
C548683:MIRN499 microRNA, human; D035683:MicroRNAs