One-step preparation and pH-tunable self-aggregation of amphoteric aliphatic polycarbonates bearing plenty of amine and carboxyl groups.
This paper reports a novel amphoteric aliphatic polycarbonate bearing both amine and carboxyl groups. In the absence of protection-deprotection chemistry, the multi-functionalized copolymer is synthesized by one-step enzymatic copolymerization. The influences of the reaction conditions including monomer feed ratio and polymerization time are explored. The simultaneous incorporation of amine and carboxyl functionalities provides the copolymer with a pH-tunable self-aggregation feature, leading to various aggregation states including precipitated agglomerate, well-dispersed positively or negatively charged nanoparticles in a controlled manner. The copolymer displays minimal cytotoxicity to 293T and HeLa cells.
Key Laboratory of Biomedical Polymers (The Ministry of Education), Department of Chemistry, Wuhan University, Wuhan, 430072, China.
Hua-Fen
HF
Wang
Hui-Zhen
HZ
Jia
Jing-Yi
JY
Zhu
Yan-Feng
YF
Chu
Jun
J
Feng
Xian-Zheng
XZ
Zhang
Ren-Xi
RX
Zhuo
D000588:Amines / Q000737:chemistry; D001672:Biocompatible Materials; D053898:Biosynthetic Pathways / Q000502:physiology*; D002021:Buffers; D002245:Carbon Dioxide / Q000737:chemistry; D002254:Carbonates / Q000737:chemistry*; D016503:Drug Delivery Systems / Q000379:methods; D057809:HEK293 Cells; D006367:HeLa Cells; D006801:Humans; D006863:Hydrogen-Ion Concentration; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D011108:Polymers / Q000737:chemistry*
D000588:Amines; D001672:Biocompatible Materials; D002021:Buffers; D002254:Carbonates; D011108:Polymers; D002245:Carbon Dioxide; C041069:carboxyl radical