[Recurrent miscarriage--causes, diagnostics and treatment].
Recurrent miscarriage (RM) is defined as three or more consecutive early pregnancy losses and affects 1% of couples. RM is probably a multifactorial disease and evaluation includes parental karyotyping, testing for uterine anomalies, thyroid dysfunction, thrombophilia and immune factors. Couples facing RM should be offered tender loving care; i.e. repeated measurements of hCG and ultrasound scans. Further treatments are directed against the underlying cause: surgery, hormone supplementation, anticoagulation and immunomodulation. However, the effect of these treatments needs further documentation.
Fertilitetsklinikken, Afsnit 4071, Juliane Marie Centret, Rigshospitalet, Blegdamsvej 9, Copenhagen. elisabeth.clare.larsen@rh.regionh.dk
Elisabeth Clare
EC
Larsen
Ole Bjarne
OB
Christiansen
D000026:Abortion, Habitual / Q000175:diagnosis / Q000209:etiology / Q000628:therapy; D002869:Chromosome Aberrations; D005260:Female; D005323:Fetal Monitoring; D006801:Humans; D007694:Killer Cells, Natural / Q000276:immunology; D011247:Pregnancy; D019851:Thrombophilia / Q000150:complications; D013959:Thyroid Diseases / Q000150:complications; D016216:Ultrasonography, Prenatal; D014599:Uterus / Q000002:abnormalities