[Effect of heavy ion beam irradiation on serum interleukin-2 level in a hamster model bearing cheek pouch carcinoma].
OBJECTIVE
To investigate the changes in serum interleukin-2 (IL-2) level in a hamster model bearing cheek pouch carcinoma after heavy ion beams irradiation.


METHODS
The serum levels of IL-2 were detected using enzyme-linked immunosorbant assay in 40 hamsters bearing cheek pouch carcinoma before and after exposure to heavy ion beam irradiation, with 8 normal animals as control.


RESULTS
Serum IL-2 level was 0.16∓0.01 in the tumor-bearing hamsters before the irradiation, lower than that in the control group. After heavy ion beams irradiation at 4, 6, 8, and 12 Gy, serum IL-2 levels in the tumor-bearing hamsters were 0.18∓0.04, 0.22∓0.05, 0.15∓0.03, and 0.13∓0.04, respectively, showing a peak level after irradiation at 6 Gy and an obvious decrease following irradiation at greater doses.


CONCLUSIONS
Heavy ion beam irradiation causes alterations in serum IL-2 level with a dose-effect relation between them in hamsters bearing cheek pouch carcinoma.
College of Stomatology, Lanzhou University, Lanzhou, China. anxl@lzu.edu.cn
Xiaoli
X
An
Qingzong
Q
Si
Bin
B
Liu
Hong
H
Zhang
D000818:Animals; D002610:Cheek / Q000473:pathology; D006224:Cricetinae; D005260:Female; D063193:Heavy Ion Radiotherapy; D007376:Interleukin-2 / Q000097:blood*; D008297:Male; D008647:Mesocricetus; D009062:Mouth Neoplasms / Q000097:blood* / Q000532:radiotherapy*
D007376:Interleukin-2