Graphene oxide strongly inhibits amyloid beta fibrillation.
Since amyloid beta fibrillation (AβF) plays an important role in the development of neurodegenerative diseases, we investigated the effect of graphene oxide (GO) and their protein-coated surfaces on the kinetics of Aβ fibrillation in the aqueous solution. We showed that GO and their protein-covered surfaces delay the AβF process via adsorption of amyloid monomers. Also, the large available surface of GO sheets can delay the AβF process by adsorption of amyloid monomers. The inhibitory effect of the GO sheet was increased when we increase the concentration from 10% (in vitro; stimulated media) to 100% (in vivo; stimulated media).


CONCLUSIONS
our results revealed that GO and their surface proteins inhibit AβF by decreasing the kinetic reaction.
Department of Nanotechnology, Faculty of Pharmacy Tehran University of Medical Sciences, P.O. Box 14155-6451, Tehran, Iran. mahmoudi-m@tums.ac.ir
Morteza
M
Mahmoudi
Omid
O
Akhavan
Mahdi
M
Ghavami
Farhad
F
Rezaee
Seyyed Mohammad Amin
SM
Ghiasi
D000327:Adsorption; D016229:Amyloid beta-Peptides / Q000737:chemistry / Q000378:metabolism*; D006108:Graphite / Q000737:chemistry*; D007700:Kinetics; D018625:Microscopy, Atomic Force; D010087:Oxides / Q000737:chemistry*; D014867:Water / Q000737:chemistry
D016229:Amyloid beta-Peptides; D010087:Oxides; D014867:Water; D006108:Graphite