Lipoic acid attenuates the expression of adhesion molecules by increasing endothelial nitric-oxide synthase activity.
We tried to study the possible effects of lipoic acid (LA) on adhesion molecule expression and its underlying mechanism in the prevention and treatment of cardiovascular disorders. Intercellular adhesion molecule-1 (ICAM-1) expression and endothelial nitric oxide synthase (eNOS) activity were determined after endothelial cells were exposed to high glucose in the absence and presence of LA. Coincubation of endothelial cells with high glucose for 24 h resulted in a significant increase of monocyte-endothelial cell adhesion and the expression of ICAM-1 (P < 0.01). These effects were abolished by LA and LA significantly increased eNOS activities (P < 0.01). These findings suggested that LA may play a role in inhibiting expression of adhesion molecules by increasing eNOS activities.
Department of Physiology, Harbin Medical University, 194 Xuefu Rd., Nangang District, Harbin 150081, People's Republic of China.
Hong-Bo
HB
Jin
Yong-Bin
YB
Yang
Ying-Li
YL
Song
Yong-Chun
YC
Zhang
Yu-Rong
YR
Li
D000975:Antioxidants / Q000494:pharmacology*; D002448:Cell Adhesion / Q000187:drug effects; D015815:Cell Adhesion Molecules / Q000378:metabolism*; D002478:Cells, Cultured; D042783:Endothelial Cells / Q000187:drug effects* / Q000378:metabolism*; D004789:Enzyme Activation; D005947:Glucose / Q000378:metabolism; D006801:Humans; D018799:Intercellular Adhesion Molecule-1 / Q000378:metabolism; D009000:Monocytes / Q000187:drug effects / Q000378:metabolism; D052250:Nitric Oxide Synthase Type III / Q000378:metabolism; D008063:Thioctic Acid / Q000494:pharmacology*
D000975:Antioxidants; D015815:Cell Adhesion Molecules; D018799:Intercellular Adhesion Molecule-1; D008063:Thioctic Acid; D052250:Nitric Oxide Synthase Type III; D005947:Glucose