In Japanese patients with type A gastritis with pernicious anemia the condition is very poorly associated with Helicobacter pylori infection.
There are conflicting views about the association between type A gastritis with pernicious anemia (PA) and infection with Helicobacter pylori, and currently, no definite conclusion has been reached. In this study, we evaluated H. pylori infection in patients with type A gastritis who developed PA. The study included a total of 25 Japanese patients (13 males and 12 females) who had been diagnosed with PA at our department, with a mean age of 71.2 years. We diagnosed infection with H. pylori by measuring serum H. pylori-IgG antibodies in all 25 patients, and we performed gastric biopsy in 17 patients. They were all negative for H. pylori-IgG antibody (0/25) and H. pylori on gastric biopsy (0/17). Although the prevalence of H. pylori infection (70-80 %) in our age-matched controls in Japan is higher than the prevalence in similar populations in western countries, we believe that type A gastritis with PA is very poorly associated with H. pylori infection.
Department of Internal Medicine and Hematology, Aiiku Hospital, Chuo-ku, Minami 4 Nishi 25, Sapporo, Japan, ikyoku@aiiku-hp.or.jp.
Makoto
M
Saito
Masanobu
M
Morioka
Kentaro
K
Wakasa
Koh
K
Izumiyama
Akio
A
Mori
Tatsuro
T
Irie
Masanori
M
Tanaka
Shinya
S
Tanaka
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000752:Anemia, Pernicious / Q000382:microbiology*; D000907:Antibodies, Bacterial / Q000097:blood; D005260:Female; D005756:Gastritis / Q000097:blood* / Q000382:microbiology*; D016481:Helicobacter Infections / Q000097:blood*; D016480:Helicobacter pylori / Q000302:isolation & purification*; D006801:Humans; D007564:Japan; D008297:Male; D008875:Middle Aged
D000907:Antibodies, Bacterial