Activity of alkanediol alkanoates against pathogenic plant fungi Rhizoctonia solani and Sclerotium rolfsii.
Thirty known dialkanoates of ethylene, propylene and diethylene glycols were synthesized by reacting the glycols with acyl chlorides and their structures confirmed by IR, NMR and mass spectral analyses. They exhibited significant antifungal activity against two phytopathogenic fungi Rhizoctonia solani Kuehn and Sclerotium rolfsii Sacc in a dose dependent manner. Propylene glycol dipentanoate was the most active against R. solani. followed by diethylene glycol dibutanoate and ethylene glycol dibutanoate. Against S. rolfsii ethylene glycol diheptanoate was found to be most active followed by diethylene glycol diisobutanoate As compared to the standard reference benomyl (EC50 5.16 microg/mL), the potential alkanediol dialkanoates showed EC50 in the range of 33 - 60 microg/mL.
Division of Agricultural Chemicals, Indian Agricultural Research Institute, New Delhi, India.
Paraj
P
Shukla
Suresh
S
Walia
Vivek
V
Ahluwalia
Balraj S
BS
Parmar
Muraleedharan G
MG
Nair
D000473:Alkanes / Q000494:pharmacology*; D000935:Antifungal Agents / Q000494:pharmacology*; D006018:Glycols / Q000494:pharmacology*; D003904:Mitosporic Fungi / Q000187:drug effects*; D012232:Rhizoctonia / Q000187:drug effects*
D000473:Alkanes; D000935:Antifungal Agents; D006018:Glycols