Methylome alterations "mark" new therapeutic opportunities in glioblastoma.
In this issue of Cancer Cell, Sturm et al. report that global DNA methylation patterns in glioblastoma multiforme divide adult and pediatric tumors into subgroups that have characteristic DNA mutations, mRNA profiles, and most importantly, different clinical behaviors. These findings suggest novel opportunities for therapeutics for this dreaded disease.
Division of Pediatric Oncology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA. eraabe2@jhmi.edu
Eric H
EH
Raabe
Charles G
CG
Eberhart