Urinary tract infection in infants: a single-center clinical analysis in southern Taiwan.
BACKGROUND
This study summarized the epidemiology, etiology, and susceptibility of pathogens to antibiotics, and specific characteristics in infants aged less than 4 months diagnosed with urinary tract infection in the past decade in Taiwan.


METHODS
The medical charts of patients aged less than 4 months admitted for urinary tract infection to Kaohsiung Veterans General Hospital between January 2001 and December 2009 were retrospectively reviewed.


RESULTS
A total of 132 patients, with male predominance (68.9%), were enrolled. The top three pathogens were similar to those identified in previous studies in Taiwan. The most common pathogen, Escherichia coli (85.3%), was resistant to ampicillin (75.9%), followed by sulfamethoxazole/trimethoprim (31.7%), and cefazolin (28.5%). Dimercaptosuccinic acid (DMSA) renal scan revealed 34.5% positive findings, while the vesicoureteral reflux (VUR) rate was 37.8% by direct radionuclide voiding cystography and/or voiding cysto-urethrography. Positive DMSA findings significantly correlated with VUR (p<0.001) and higher C-reactive protein level (p<0.05).


CONCLUSIONS
E coli was the most common pathogen in the present cohort, and the top three pathogens were similar to those found in general pediatric population in Taiwan. VUR was the most common genitourinary tract anomaly in this age group. Positive DMSA was well correlated with VUR and higher C-reactive protein level.
Department of Pediatrics, Su-Ao Branch of Taipei Veterans General Hospital, Yi-lan, Taiwan.
Jen-Hsi
JH
Wu
Yee-Hsuan
YH
Chiou
Jenn-Tzong
JT
Chang
Hsiao-Ping
HP
Wang
Ying-Yao
YY
Chen
Kai-Sheng
KS
Hsieh
D017677:Age Distribution; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D015331:Cohort Studies; D024881:Drug Resistance, Bacterial; D004927:Escherichia coli Infections / Q000175:diagnosis / Q000188:drug therapy*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D015994:Incidence; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D008826:Microbial Sensitivity Tests; D012189:Retrospective Studies; D018570:Risk Assessment; D017678:Sex Distribution; D013624:Taiwan / Q000453:epidemiology; D016896:Treatment Outcome; D014552:Urinary Tract Infections / Q000188:drug therapy* / Q000453:epidemiology* / Q000209:etiology; D014718:Vesico-Ureteral Reflux / Q000150:complications* / Q000175:diagnosis
D000900:Anti-Bacterial Agents