Synthesis of sterically encumbered C10-arylated benzo[h]quinolines using ortho-substituted aryl boronic acids.
The challenging coupling of 10-halobenzo[h]quinolines with ortho-substituted aryl boronic acids has been achieved using Pd(OAc)(2)/P(O)Ph(3) as the catalytic system. High yields were obtained for diversely functionalised substrates under mild reaction conditions.
Department of Chemistry, Imperial College London, London SW7 2AZ, UK.
Marko
M
Weimar
Matthew J
MJ
Fuchter
D001897:Boronic Acids / Q000737:chemistry*; D015394:Molecular Structure; D011804:Quinolines / Q000138:chemical synthesis* / Q000737:chemistry; D013237:Stereoisomerism
D001897:Boronic Acids; D011804:Quinolines; C039107:benzo(h)quinoline