Nickel-mediated oxidative fluorination for PET with aqueous [18F] fluoride.
A one-step oxidative fluorination for carbon-fluorine bond formation from well-defined nickel complexes with oxidant and aqueous fluoride is presented, which enables a straightforward and practical (18)F late-stage fluorination of complex small molecules with potential for PET imaging.
Department of Chemistry and Chemical Biology, Harvard University, 12 Oxford Street, Cambridge, Massachusetts 02138, USA.
Eunsung
E
Lee
Jacob M
JM
Hooker
Tobias
T
Ritter
D005461:Fluorine / Q000737:chemistry*; D005462:Fluorine Radioisotopes; D015394:Molecular Structure; D009532:Nickel / Q000737:chemistry*; D009942:Organometallic Compounds / Q000138:chemical synthesis / Q000737:chemistry*; D010084:Oxidation-Reduction; D049268:Positron-Emission Tomography; D014867:Water / Q000737:chemistry
D005462:Fluorine Radioisotopes; D009942:Organometallic Compounds; D014867:Water; D005461:Fluorine; D009532:Nickel