[Cells of mononuclear phagocytes system of liver and lung in rats after intravenous application of magnetite nanoparticles].
The article describes changes in the morphology and localization of the cells of mononuclear phagocyte system of liver and lung in rats at different times after single and repeated intravenous administration of a suspension of nanoparticles of magnetite (NPM). Mechanisms for removal of nanoparticles of magnetite from the rat body with the participation of mononuclear phagocytes of the liver (removal of the particles by stellate macrophages in the gastroenteric tract with bile) and of the lung (by migration of the alveolar macrophages in the gleam of the bronchial tree) have been illustrated. It has been shown that intravenous application of nanomagnetite causes changes in the morphology of the internal organs of rats and the severity of these changes increases with increasing total dose injected magnetite.
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Mil'to
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Sukhodolo
V Iu
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Usov
D000818:Animals; D004305:Dose-Response Relationship, Drug; D055166:Hepatic Stellate Cells / Q000166:cytology / Q000378:metabolism; D008099:Liver / Q000378:metabolism / Q000473:pathology*; D008168:Lung / Q000378:metabolism / Q000473:pathology*; D016676:Macrophages, Alveolar / Q000166:cytology / Q000378:metabolism; D058185:Magnetite Nanoparticles / Q000008:administration & dosage / Q000009:adverse effects*; D008297:Male; D012157:Mononuclear Phagocyte System / Q000473:pathology*; D010587:Phagocytosis; D051381:Rats
D058185:Magnetite Nanoparticles