Polymer nanoreactors shown to produce and release antibiotics locally.
We designed and prepared nanoreactors based on a poly(2-methyloxazoline)-block-poly(dimethylsiloxane)-block-poly(2-methyloxazoline (PMOXA-b-PDMS-b-PMOXA) amphiphilic triblock copolymer encapsulating the enzyme penicillin acylase for local and controlled production of antibiotics.
Department of Chemistry, University of Basel, Klingelbergstrasse 80, CH-4056 Basel, Switzerland.
Karolina
K
Langowska
Cornelia G
CG
Palivan
Wolfgang
W
Meier
D000900:Anti-Bacterial Agents / Q000378:metabolism* / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects; D019149:Bioreactors; D002506:Cephalexin / Q000378:metabolism / Q000494:pharmacology; D052978:Disk Diffusion Antimicrobial Tests; D036103:Nanotechnology; D010080:Oxazoles / Q000737:chemistry*; D010399:Penicillin Amidase / Q000378:metabolism; D011108:Polymers / Q000737:chemistry*
D000900:Anti-Bacterial Agents; D010080:Oxazoles; D011108:Polymers; C542789:poly(2-methyl oxazoline)-block polydimethylsiloxane-block-poly(2-methyl oxazoline); D010399:Penicillin Amidase; D002506:Cephalexin