[Diagnostic value of blood myoglobin level elevation in patient in intensive care unit].
The goal of the study was assessment of clinical value of myoglobin level elevation in patients in neurointensive care unit. 15 healthy volunteers and 60 patients of neuroICU (40 postoperative patients and 20 patients with prolonged consciousness disorders of different states) were involved in the study. Myoglobin level was assessed immunologically. Episodes of arterial hypotension (< or = 50% from baseline) for 10-15 minutes were the cause of myoglobin level elevation in 11 from 40 postoperative patients. Association of myoglobin level elevation with type of pathology (tumor or aneurism), localization and surgery duration wasn't found. Severe hemodynamic disturbances with hypotension in 3-4 days before measurement were noted also in patients with hypermyoglobinemia in the group with prolonged consciousness disorders. Correlation of myoglobin level and duration of polyneuromyopathy, sepsis, MODS wasn't noted. Authors conclude that myoglobin level elevation is associate with hemodynamic instability and isn't specific marker of polyneuromyopathy or its duration.
D000328:Adult; D000783:Aneurysm / Q000473:pathology / Q000601:surgery; D015415:Biomarkers / Q000097:blood; D016022:Case-Control Studies; D003244:Consciousness Disorders / Q000175:diagnosis / Q000503:physiopathology*; D005260:Female; D006439:Hemodynamics; D006801:Humans; D007022:Hypotension / Q000175:diagnosis / Q000503:physiopathology*; D007362:Intensive Care Units; D008297:Male; D009102:Multiple Organ Failure / Q000503:physiopathology; D009211:Myoglobin / Q000097:blood*; D009369:Neoplasms / Q000473:pathology / Q000601:surgery; D011115:Polyneuropathies / Q000175:diagnosis / Q000503:physiopathology*; D018805:Sepsis / Q000503:physiopathology; D012720:Severity of Illness Index; D055815:Young Adult
D015415:Biomarkers; D009211:Myoglobin