Prevalence of osteoporosis and osteopenia in Thai COPD patients.
OBJECTIVE
To study the prevalence of osteoporosis and osteopenia in Thai COPD patients and the factors associated with osteoporosis.


METHODS
A cross sectional study was used to evaluate 102 male stable COPD patients. Bone mineral density at lumbar spine (L2-4) and femoral neck were measured by dual energy x-ray absorptiometer scan. Demographic data including age, body mass index (BMI), inhaled corticosteroids use, tobacco smoke, force expiratory volume at 1 second (FEV1), and high sensitivity C-reactive protein (hs-CRP) were analyzed.


RESULTS
The overall prevalence of osteoporosis and osteopenia according to the lowest T-score at either L2-4 or femoral neck were 31.4% and 32.4%, respectively. This prevalence of osteoporosis in COPD patients was higher than that in age-matched Thai males from historical data (31.4% vs. 12.6%, respectively). BMI and hs-CRP were significantly associated with osteoporosis. There was no association between osteoporosis and severity of COPD, age, smoking, and corticosteroid use. The predictive value of BMI < 20.5 kg/m2 and hs-CRP > 2.3 mg/L demonstrated risk of osteoporosis in COPD patients (adjusted Odds ratio 7.2 and 4.1, respectively).


CONCLUSIONS
The prevalence of osteoporosis and osteopenia in Thai COPD patients was higher than that in normal age-matched Thai males. Osteoporosis was associated with low BMl and high level of hs-CRP when compared to COPD patients with normal bone mineral density.
Division of Respiratory Diseases and Tuberculosis, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand. sinym@mahidol.ac.th
Nuttapol
N
Rittayamai
Benjamas
B
Chuaychoo
Apiradee
A
Sriwijitkamol
D000368:Aged; D015992:Body Mass Index; D001851:Bone Diseases, Metabolic / Q000150:complications*; D002097:C-Reactive Protein / Q000032:analysis; D003430:Cross-Sectional Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D010024:Osteoporosis / Q000150:complications*; D015995:Prevalence; D029424:Pulmonary Disease, Chronic Obstructive / Q000150:complications*; D013785:Thailand
D002097:C-Reactive Protein