Chlorosilane-promoted addition reaction of isocyanides to 3,4-dihydroisoquinoline N-oxides.
The addition reaction of isocyanides to 3,4-dihydroisoquinoline N-oxides in the presence of TMSCl has been demonstrated, with the corresponding 1,2,3,4-tetrahydroisoquinoline-1-carboxylamides being obtained in moderate to high yields. A wide range of 3,4-dihydroisoquinoline N-oxides and isocyanides were applicable to this reaction.
Division of Material Sciences, Graduate School of Natural Science and Technology, Kanazawa University, Kakuma, Kanazawa 920-1192, Japan. soeta@se.kanazawa-u.ac.jp
Takahiro
T
Soeta
Shuhei
S
Fujinami
Yutaka
Y
Ukaji
D003486:Cyanides / Q000737:chemistry*; D007546:Isoquinolines / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D012821:Silanes / Q000737:chemistry*; D044005:Tetrahydroisoquinolines / Q000737:chemistry*
D003486:Cyanides; C109852:G 1616; D007546:Isoquinolines; D012821:Silanes; D044005:Tetrahydroisoquinolines