Neural correlates of stress- and food cue-induced food craving in obesity: association with insulin levels.
OBJECTIVE
Obesity is associated with alterations in corticolimbic-striatal brain regions involved in food motivation and reward. Stress and the presence of food cues may each motivate eating and engage corticolimibic-striatal neurocircuitry. It is unknown how these factors interact to influence brain responses and whether these interactions are influenced by obesity, insulin levels, and insulin sensitivity. We hypothesized that obese individuals would show greater responses in corticolimbic-striatal neurocircuitry after exposure to stress and food cues and that brain activations would correlate with subjective food craving, insulin levels, and HOMA-IR.


METHODS
Fasting insulin levels were assessed in obese and lean subjects who were exposed to individualized stress and favorite-food cues during functional MRI.


RESULTS
Obese, but not lean, individuals exhibited increased activation in striatal, insular, and hypothalamic regions during exposure to favorite-food and stress cues. In obese but not lean individuals, food craving, insulin, and HOMA-IR levels correlated positively with neural activity in corticolimbic-striatal brain regions during favorite-food and stress cues. The relationship between insulin resistance and food craving in obese individuals was mediated by activity in motivation-reward regions including the striatum, insula, and thalamus.


CONCLUSIONS
These findings demonstrate that obese, but not lean, individuals exhibit increased corticolimbic-striatal activation in response to favorite-food and stress cues and that these brain responses mediate the relationship between HOMA-IR and food craving. Improving insulin sensitivity and in turn reducing corticolimbic-striatal reactivity to food cues and stress may diminish food craving and affect eating behavior in obesity.
Section of Endocrinology, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT, USA.
Ania M
AM
Jastreboff
Rajita
R
Sinha
Cheryl
C
Lacadie
Dana M
DM
Small
Robert S
RS
Sherwin
Marc N
MN
Potenza
D000328:Adult; D056912:Binge-Eating Disorder / Q000097:blood / Q000503:physiopathology*; D001921:Brain / Q000502:physiology*; D003463:Cues; D005260:Female; D006801:Humans; D007328:Insulin / Q000097:blood*; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000097:blood* / Q000503:physiopathology*; D013315:Stress, Psychological / Q000503:physiopathology*
D007328:Insulin