Human leukocyte antigens as a risk factor for the primary diseases leading to end stage renal disease in Egyptian patients.
The number of patients with end stage renal disease (ESRD) is increasing considerably worldwide. The incidence of ESRD is likely to be higher than that reported from the developed world, with diabetic nephropathy, hypertension and chronic glomerulonephritis being the most common causes in Egypt. The aim of the present study is to investigate the Human leukocyte antigens [HLA-A,-B and -DRB1 antigens] as a risk factor for the primary diseases leading to ESRD in Egyptian patients. Our study included a total of 457 individuals comprising 207 ESRD patients and 250 healthy controls were enrolled into the study. Class I [HLA-A and-B] typing was performed by complement-dependent cytotoxicity (CDC) method, while class II HLA-DRB1 typing was performed by low resolution polymerase chain reaction (PCR)-sequence-specific oligonucleotide probe [PCR-SSOP]. We found that the most common primary disease groups leading to ESRD classified as Diabetic nephropathy, hypertensive nephrosclerosis and chronic glomerulonephritis. HLA-A2, -B8 and DRB1*3 and HLA-DRB1*11 significantly correlated with diabetic nephropathy, respectively. B8-DR3 haplotype is susceptible to DM. In, conclusion, determination of HLA-A,-B and -DRB1 as a risk factor for primary diseases leading to ESRD might be beneficial in preventing progression to ESRD and recurrence of the primary disease post-transplantation.
Clinical Pathology Department, Faculty of Medicine, Assiut University, Egypt.
Ebtesam M
EM
El-Gezawy
Hesham A Abdel
HA
Baset
Khalid A
KA
Nasif
Amany
A
Osama
Hanan G
HG
AbdelAzeem
Medhat
M
Ali
Rasha Y
RY
Khalil
D000293:Adolescent; D000328:Adult; D002648:Child; D003928:Diabetic Nephropathies / Q000276:immunology; D004534:Egypt; D005260:Female; D005921:Glomerulonephritis / Q000276:immunology; D015234:HLA-A Antigens / Q000097:blood*; D015235:HLA-B Antigens / Q000097:blood*; D059811:HLA-DRB1 Chains / Q000097:blood*; D006801:Humans; D007676:Kidney Failure, Chronic / Q000276:immunology*; D016015:Logistic Models; D008297:Male; D009400:Nephrosclerosis / Q000276:immunology; D012307:Risk Factors; D055815:Young Adult
D015234:HLA-A Antigens; D015235:HLA-B Antigens; D059811:HLA-DRB1 Chains