Orthogonal C-N plus C-C tandem reaction of iodoanilines leading to styrylguanidines catalyzed by supported palladium nanoparticles.
Two birds, one nanoparticle: A highly efficient and selective tandem reaction comprising C-N and C-C cross-coupling of iodoanilines to form styrylguanidines by using a recyclable, heterogeneous, supported palladium nanoparticle catalyst is reported (see scheme). A mechanistic proposal based on coordination of palladium nanoparticles to the basic N atoms of aniline and guanidine is supported by isolation of palladium complexes with aniline or guanidine.
Instituto Universitario de Tecnología Química CSIC-UPV, Univ. Politécnica de Valencia, Av. De los Naranjos s/n, 46022 Valencia, Spain.
Abdessamad
A
Grirrane
Hermenegildo
H
Garcia
Avelino
A
Corma
Eleuterio
E
Álvarez
D000814:Aniline Compounds / Q000737:chemistry*; D002384:Catalysis; D006146:Guanidines / Q000138:chemical synthesis* / Q000737:chemistry*; D053768:Metal Nanoparticles / Q000737:chemistry*; D015394:Molecular Structure; D010165:Palladium / Q000737:chemistry*
D000814:Aniline Compounds; D006146:Guanidines; D010165:Palladium