Cytogenetic and molecular genetic study on granular cell glioblastoma: a case report.
Granular cell astrocytoma is a rare infiltrative malignant glioma with prominent granular cell change. Granular cell astrocytomas are biologically aggressive compared with conventional infiltrating astrocytomas of similar grades, but their genetic alterations are poorly known. We report a case of granular cell glioblastoma and its genetic and molecular features. Histologically, the tumor not only showed features typical of granular cell astrocytoma but also demonstrated frequent mitoses, pseudopalisading necrosis, and vascular endothelial hyperplasia, compatible with glioblastoma. Array-based comparative genomic hybridization and focused molecular genetic analyses demonstrated gain of chromosome 7; losses of chromosome 1p, 8p, 9p, 10, 13q, and 22q; amplification of epidermal growth factor receptor; and homozygous deletion of CDKN2A as well as MGMT promoter methylation. However, neither isocitrate dehydrogenase 1 mutation nor codeletion of 1p/19q was found. Our results indicate that granular cell glioblastomas, despite having its peculiar granular cell changes, share common molecular genetic features with conventional glioblastoma, especially the classical subtype.
Department of Pathology, Ilsan Paik Hospital, Inje University College of Medicine, Goyang, Republic of Korea.
Mee
M
Joo
Sung-Hye
SH
Park
Sun Hee
SH
Chang
Hanseong
H
Kim
Chan-Young
CY
Choi
Chae-Heuck
CH
Lee
Byung Hoon
BH
Lee
Yoon Joon
YJ
Hwang
D001932:Brain Neoplasms / Q000235:genetics* / Q000473:pathology / Q000601:surgery / Q000628:therapy; D025063:Chromosome Disorders; D002877:Chromosomes, Human / Q000235:genetics*; D002878:Chromosomes, Human, Pair 1 / Q000235:genetics; D002879:Chromosomes, Human, Pair 10 / Q000235:genetics; D002882:Chromosomes, Human, Pair 13 / Q000235:genetics; D002892:Chromosomes, Human, Pair 22 / Q000235:genetics; D002897:Chromosomes, Human, Pair 7 / Q000235:genetics; D002898:Chromosomes, Human, Pair 8 / Q000235:genetics; D002899:Chromosomes, Human, Pair 9 / Q000235:genetics; D019941:Cyclin-Dependent Kinase Inhibitor p16 / Q000235:genetics; D019175:DNA Methylation; D015254:DNA Modification Methylases / Q000235:genetics; D045643:DNA Repair Enzymes / Q000235:genetics; D018572:Disease-Free Survival; D066246:ErbB Receptors / Q000235:genetics; D005260:Female; D005500:Follow-Up Studies; D005909:Glioblastoma / Q000235:genetics* / Q000473:pathology / Q000601:surgery / Q000628:therapy; D016586:Granular Cell Tumor / Q000235:genetics* / Q000473:pathology / Q000601:surgery / Q000628:therapy; D006801:Humans; D008875:Middle Aged; D011401:Promoter Regions, Genetic; D013702:Temporal Lobe / Q000473:pathology*; D025521:Tumor Suppressor Proteins / Q000235:genetics
D019941:Cyclin-Dependent Kinase Inhibitor p16; D025521:Tumor Suppressor Proteins; D015254:DNA Modification Methylases; C515491:MGMT protein, human; D066246:ErbB Receptors; D045643:DNA Repair Enzymes