Meniscus reconstruction: today's achievements and premises for the future.
Injuries of the meniscus remain a burden for the development of premature cartilage degeneration and osteoarthritis. This review surveys all treatment options and focuses on the recent development of tissue engineering. Tissue engineering of the meniscus means a successful combination of cells, scaffolds and specific stimuli. Each element of the combination can be subject to variation. Studies investigating the optimum meniscus implant and previous steps in producing these implants are presented in this article. A comprehensive search of the English and German literature was performed in PubMed to retrieve appropriate manuscripts for review. Based on the literatures, autografts and allografts can delay the progress of osteoarthritis for a restricted time period, but several concerns persist. The biomechanical properties of the native meniscus are not copied entirely by the current existing autografts. Congruence, fixation, biocompatibility and potential infection will always remain as limitations for the users of allografts. Long-term results are still not available for meniscus prosthesis and even though it permits fast recovery, several aspects are questionable: bioincompatibility and a lack of cellular adhesion are likely to compromise their long-term fate. Currently, there is no ideal implant generated by means of tissue engineering. However, meniscus tissue engineering is a fast developing field, which promises to develop an implant that mimics histological and biomechanical properties of the native meniscus. At present several cell sources and scaffolds have been used successfully to grow 3-dimensional constructs. In future, optimal implants have to be developed using growth factors, modified scaffolds and stimuli that support cellular proliferation and differentiation to regenerate the native meniscus more closely.
Department of Orthopedic Trauma, Hannover Medical School (MHH), OE 6230 Carl-Neuberg-Straße 1, 30625 Hanover, Germany. liuchaoxu.0914@yahoo.com.cn
Chaoxu
C
Liu
Ionel Cristian
IC
Toma
Maddalena
M
Mastrogiacomo
Christian
C
Krettek
Gabriela
G
von Lewinski
Michael
M
Jagodzinski
D064987:Cell- and Tissue-Based Therapy; D006801:Humans; D008592:Menisci, Tibial / Q000601:surgery*; D020370:Osteoarthritis, Knee / Q000209:etiology / Q000517:prevention & control / Q000628:therapy*; D053657:Platelet-Rich Plasma; D019736:Prostheses and Implants; D012038:Regeneration; D000070600:Tibial Meniscus Injuries; D023822:Tissue Engineering / Q000639:trends; D054457:Tissue Scaffolds; D014182:Transplantation, Autologous; D014184:Transplantation, Homologous; D019737:Transplants