Wound modulation after filtration surgery.
Filtration surgery is the standard invasive procedure for the management of intraocular pressure in advanced glaucoma. The key to a successful outcome is to modulate the normal wound healing cascade that leads to closure of the newly created aqueous outflow pathway. Antifibrotic agents such as mitomycin C and 5-fluorouracil have been increasingly used to modulate the wound healing process and increase surgical success. Although these agents have proven efficacy, they also increase the risk of complications. Efforts have centered on the identification of novel agents and techniques that can influence wound modulation without these complications. We detail new agents and methods under investigation to control wound healing after filtration surgery.
Rocky Mountain Lions Eye Institute, Department of Ophthalmology, University of Colorado at Denver, Aurora, Colorado, USA.
Leonard K
LK
Seibold
Mark B
MB
Sherwood
Malik Y
MY
Kahook
D000477:Alkylating Agents / Q000008:administration & dosage; D000963:Antimetabolites / Q000008:administration & dosage; D018463:Filtering Surgery; D005901:Glaucoma / Q000601:surgery*; D006801:Humans; D007166:Immunosuppressive Agents / Q000008:administration & dosage; D014945:Wound Healing / Q000502:physiology*
D000477:Alkylating Agents; D000963:Antimetabolites; D007166:Immunosuppressive Agents