Potential of microRNAs for cancer diagnostics, prognostication and therapy.
OBJECTIVE
MicroRNAs (miRNAs) are small regulatory RNAs that are frequently deregulated in cancer and have shown great potential as biomarkers for cancer diagnosis and prognostication. Recent studies also support great promise in targeting miRNAs in cancer.


RESULTS
In this review, we will discuss the most important aspects about the use of miRNAs for the diagnosis, prognosis and therapy in cancer, including current pitfalls and future directions.


CONCLUSIONS
The definitive establishment of miRNAs as biomarkers and as therapeutic targets in cancer will likely have a profound impact on clinical practice and research.
Division of Hematology, Department of Medicine, The Comprehensive Cancer Center, Ohio State University, Columbus, Ohio, USA.
Ramiro
R
Garzon
Guido
G
Marcucci
D000818:Animals; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D035683:MicroRNAs / Q000097:blood* / Q000235:genetics / Q000378:metabolism; D058990:Molecular Targeted Therapy; D009369:Neoplasms / Q000175:diagnosis* / Q000378:metabolism / Q000628:therapy; D011379:Prognosis; D059467:Transcriptome
D035683:MicroRNAs