Interstitial pulmonary fibrosis and progressive massive fibrosis related to smoking methamphetamine with talc as filler.
We present a case of interstitial pulmonary fibrosis accompanied by radiographic evidence of progressive massive fibrosis in a patient who had a 15-20 year history of almost daily recreational inhalation of methamphetamine. Mineralogical analysis confirmed the presence of talc on biopsy of the area of progressive massive fibrosis. The coexistence of interstitial pulmonary fibrosis and progressive massive fibrosis suggests that prolonged recreational inhalation of methamphetamine that has been "cut" with talc can result in sufficient amount of talc being inhaled to result in interstitial pulmonary fibrosis and progressive massive fibrosis in the absence of other causes.
Veterans Administration Central California Health Care System, Fresno, California 93703, USA. Peter.Baylor@va.gov
Peter A
PA
Baylor
Juan R
JR
Sobenes
Val
V
Vallyathan
D019969:Amphetamine-Related Disorders / Q000150:complications; D006801:Humans; D019570:Inhalation Exposure / Q000009:adverse effects*; D008297:Male; D008694:Methamphetamine / Q000506:poisoning; D008875:Middle Aged; D011009:Pneumoconiosis / Q000209:etiology*; D011658:Pulmonary Fibrosis / Q000139:chemically induced* / Q000000981:diagnostic imaging* / Q000473:pathology; D011859:Radiography; D013627:Talc / Q000506:poisoning*
D013627:Talc; D008694:Methamphetamine