Regeneration: the ultimate example of wound healing.
The outcome of wound repair in mammals is often characterized by fibrotic scaring. Vertebrates such as zebrafish, frogs, and salamanders not only heal scarlessly, but also can regenerate lost appendages. Decades of study on the process of animal regeneration has produced key insights into the mechanisms of how complex tissue is restored. By examining our current knowledge of regeneration, we can draw parallels with mammalian wound healing to identify the molecular determinants that produce such differing outcomes.
Technische Universität Dresden, DFG Center for Regenerative Therapies, Fetscherstrasse 105, Dresden 01307, Germany.
Prayag
P
Murawala
Elly M
EM
Tanaka
Joshua D
JD
Currie
D000818:Animals; D001001:Anura / Q000502:physiology; D002465:Cell Movement; D002921:Cicatrix / Q000517:prevention & control; D020405:Dermis / Q000166:cytology / Q000502:physiology; D000078404:Epidermal Cells; D004817:Epidermis / Q000502:physiology; D005109:Extracellular Matrix / Q000502:physiology; D005347:Fibroblasts / Q000166:cytology / Q000502:physiology; D015603:Keratinocytes / Q000166:cytology / Q000502:physiology; D008322:Mammals / Q000502:physiology; D062326:Re-Epithelialization / Q000502:physiology; D012038:Regeneration / Q000502:physiology*; D013045:Species Specificity; D014562:Caudata / Q000502:physiology; D014945:Wound Healing / Q000502:physiology*