Concentration-independent pH detection with a luminescent dimetallic Eu(III)-based probe.
A pH-responsive, luminescent, dimetallic Eu(III)-containing complex has been synthesized and exhibits a unique mechanism of response. The luminescence-decay rate of the complex is slow, due to a lack of water molecules coordinated to the Eu(III) ions. However, the luminescence-decay rate decreases with increasing pH over a biologically relevant range of 4-8. Physical characterization and computational analysis suggest that the pH response is due to protonation of a bridging alkoxide at lower pH values. Modulation of the luminescence-decay rate is independent from the concentration of Eu(III), which we expect to be useful in the non-invasive imaging of in vivo pH.
Department of Chemistry, Wayne State University, Detroit, Michigan 48202, USA.
Jeremiah D
JD
Moore
Richard L
RL
Lord
G Andrés
GA
Cisneros
Matthew J
MJ
Allen
D056831:Coordination Complexes / Q000138:chemical synthesis / Q000737:chemistry*; D005063:Europium / Q000737:chemistry*; D006863:Hydrogen-Ion Concentration; D049449:Luminescence; D049408:Luminescent Agents / Q000138:chemical synthesis / Q000737:chemistry*; D008958:Models, Molecular; D015394:Molecular Structure
D056831:Coordination Complexes; D049408:Luminescent Agents; D005063:Europium