Inhibition of virus-like particle release of Sendai virus and Nipah virus, but not that of mumps virus, by tetherin/CD317/BST-2.
Tetherin (also known as BST-2 or CD317) has recently been identified as a potent IFN-induced anti-viral protein that inhibits the release of diverse enveloped virus particles from infected cells. The anti-viral activity of tetherin on a number of enveloped viruses, including retroviruses, filoviruses and arenaviruses, has been examined. Here, we show that tetherin is also capable of blocking the release of virus-like particles (VLPs) driven by the matrix protein of Sendai virus. Together with inhibition of Nipah virus VLP release by tetherin, these results indicate that paramyxoviruses are to be added to the list of viruses that are susceptible to tetherin inhibition. Tetherin co-localized with Nipah virus matrix proteins and accumulated in cells, indicating that it is present at, or recruited to, sites of particle assembly. It should be noted, however, that tetherin was not effective against the release of paramyxovirus mumps VLPs, indicating that certain enveloped viruses may not be sensitive to tetherin activity.
Department of Virology, Institute of Biomedical & Health Sciences, Hiroshima University, Hiroshima 734-8551, Japan.
Weng-Sheng
WS
Kong
Takashi
T
Irie
Asuka
A
Yoshida
Ryoko
R
Kawabata
Takahiro
T
Kadoi
Takemasa
T
Sakaguchi
D015703:Antigens, CD / Q000378:metabolism*; D058851:GPI-Linked Proteins / Q000378:metabolism; D057809:HEK293 Cells; D045464:Henipavirus Infections / Q000378:metabolism* / Q000821:virology; D054298:Human Immunodeficiency Virus Proteins / Q000378:metabolism; D006801:Humans; D009107:Mumps / Q000378:metabolism / Q000821:virology; D009109:Mumps virus / Q000254:growth & development; D045405:Nipah Virus / Q000254:growth & development*; D010253:Respirovirus Infections / Q000378:metabolism* / Q000821:virology; D029082:Sendai virus / Q000254:growth & development*; D054334:Viral Regulatory and Accessory Proteins / Q000378:metabolism; D000074010:Bone Marrow Stromal Antigen 2; D000086082:Viroporin Proteins
D015703:Antigens, CD; D058851:GPI-Linked Proteins; D054298:Human Immunodeficiency Virus Proteins; D054334:Viral Regulatory and Accessory Proteins; C094572:BST2 protein, human; D000074010:Bone Marrow Stromal Antigen 2; C514859:vpu protein, Human immunodeficiency virus 1; D000086082:Viroporin Proteins