[Cyclooxigenase-1 gene polymorphism and aspirin resistance].
The literature data concerning structure of cyclo-oxigenase-1--the key enzyme in prostaglandin biosynthesis and the main target of anti-platelet therapy with the use of acetylsalicilic acid are presented in the review. The data on cyclooxigenase-1 gene polymorphism, distribution of the revealed variants in various populations and their possible correlation with biochemical and functional aspirin resistance are presented.
T N
TN
Bondar'
N A
NA
Kravchenko
D000483:Alleles; D001241:Aspirin / Q000494:pharmacology / Q000627:therapeutic use*; D001792:Blood Platelets / Q000187:drug effects; D051545:Cyclooxygenase 1 / Q000235:genetics / Q000378:metabolism*; D016861:Cyclooxygenase Inhibitors / Q000494:pharmacology / Q000627:therapeutic use*; D004351:Drug Resistance; D005787:Gene Frequency; D006801:Humans; D007249:Inflammation / Q000188:drug therapy* / Q000201:enzymology / Q000235:genetics; D007527:Isoenzymes / Q000235:genetics / Q000378:metabolism; D010974:Platelet Aggregation / Q000187:drug effects; D010975:Platelet Aggregation Inhibitors / Q000494:pharmacology / Q000627:therapeutic use*; D011110:Polymorphism, Genetic; D011453:Prostaglandins / Q000096:biosynthesis
D016861:Cyclooxygenase Inhibitors; D007527:Isoenzymes; D010975:Platelet Aggregation Inhibitors; D011453:Prostaglandins; D051545:Cyclooxygenase 1; C496511:PTGS1 protein, human; D001241:Aspirin