The taming of the NF-κB: PP4R1 navigates while PP4c dephosphorylates.
The NF-κB signaling pathway is important in the regulation of physiological and malignant hematopoiesis. In this issue of Immunity, Brechmann et al. (2012) identify a phosphatase, PP4R1, that inhibits NF-κB activation in T cells and T cell lymphoma.
Howard Hughes Medical Institute, New York University School of Medicine, NY 10016, USA.
Anastasia
A
Tikhonova
Iannis
I
Aifantis