[The mirochondrial lipid palmitate/Ca2+-induced pore and its possible role in a degradation of nervous cells].
The subject of the review is a new type of mitochondrial pore--a pore which has lipid nature and is induced by palmitic acid and Ca2+. The review considers molecular mechanisms of its formation and regulation, conditions of its opening in biological membranes and the role in physiological and pathophysiological processes. Also discussed is involvement of the lipid pore in glutamate-induced degradation of nervous cells.
K N
KN
Belosludtsev
G D
GD
Mironova
D000818:Animals; D017209:Apoptosis / Q000187:drug effects*; D002118:Calcium / Q000378:metabolism*; D006801:Humans; D015640:Ion Channel Gating / Q000187:drug effects / Q000502:physiology; D008051:Lipid Bilayers / Q000378:metabolism; D008930:Mitochondria, Liver / Q000187:drug effects / Q000378:metabolism; D033681:Mitochondrial Membrane Transport Proteins / Q000378:metabolism / Q000502:physiology*; D000083162:Mitochondrial Permeability Transition Pore; D008933:Mitochondrial Swelling / Q000187:drug effects / Q000502:physiology; D009474:Neurons / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology; D019308:Palmitic Acid / Q000494:pharmacology*
D008051:Lipid Bilayers; D033681:Mitochondrial Membrane Transport Proteins; D000083162:Mitochondrial Permeability Transition Pore; D019308:Palmitic Acid; D002118:Calcium