Protective effect of lactoferrin on Cisplatin-induced nephrotoxicity in rats.
Although cisplatin (cis-diamminedichloroplatinum II) is one of the most effective chemotherapeutic agents, its clinical use is limited because of its strong side effects on the kidneys. The aim of this study was to investigate the renoprotective effect of bovine lactoferrin (bLf) in cisplatin-induced renal failure in rats. To assess the renoprotective effect of bLf, oral bLf (300 mg/kg) was administered from the day before to the fifth day after cisplatin (7 mg/kg, i.p.) injection. Daily administration of bLf histologically reduced renal tubular injury induced by cisplatin and suppressed the deterioration of renal function. Accumulated platinum content in the kidney was significantly decreased by the daily administration of bLf. Moreover, the administration of intravenous bLf caused a significant increase in urine volume in a dose-dependent manner. These results suggest that pretreatment with bLf produces a protective effect against cisplatin-induced nephrotoxicity. This protective effect of bLf involves the reduction of accumulated cisplatin in the kidney.
United Graduate School of Veterinary Science, Yamaguchi University, Yamaguchi, Japan.
Yumi
Y
Kimoto
Masaaki
M
Nishinohara
Akihiko
A
Sugiyama
Akihiro
A
Haruna
Takashi
T
Takeuchi
D000818:Animals; D000970:Antineoplastic Agents / Q000633:toxicity; D002945:Cisplatin / Q000633:toxicity*; D004231:Diuresis / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D007674:Kidney Diseases / Q000139:chemically induced* / Q000517:prevention & control; D007781:Lactoferrin / Q000008:administration & dosage / Q000494:pharmacology*; D051381:Rats
D000970:Antineoplastic Agents; D007781:Lactoferrin; D002945:Cisplatin