Oncophagy: harnessing regulation of autophagy in cancer therapy.
Autophagy is an increasingly well-characterised process of cell component auto-digestion and recycling thought necessary for cellular subsistence. As we gain a more thorough understanding of the mechanisms underlying autophagy, its relevance to human disease and therapeutic potential are being clarified. This review summarises the evidence implicating autophagy in the pathogenesis and potential treatment of malignant disease. In addition, we explore the molecular role of microRNAs as key regulators in what we propose should now become known as 'oncophagy'.
Cancer Genetics, Kolling Institute of Medical Research, University of Sydney, Pacific Highway, St Leonards, Sydney, New South Wales 2065, Australia.
Justin S
JS
Gundara
JingTing
J
Zhao
Bruce G
BG
Robinson
Stan B
SB
Sidhu
D000818:Animals; D001343:Autophagy; D006801:Humans; D035683:MicroRNAs / Q000378:metabolism; D009369:Neoplasms / Q000235:genetics / Q000473:pathology / Q000628:therapy*
D035683:MicroRNAs