Diversity of IL-17-producing T lymphocytes.
Interleukin (IL)-17 is a pro-inflammatory cytokine that plays critical roles in host defense against extracellular bacteria and fungi and also in the pathogenesis of autoimmune diseases. While CD4+ TCRαβ+ T helper (Th) 17 cells are the best-described cellular source of IL-17, many innate-like T cells are in fact potent producers of IL-17. Given the increasing interest in therapeutic modulation of the IL-17 axis, it is crucial to better understand the cellular origins of IL-17 in various infection and diseases settings. While the diverse population of IL-17-producing T cells share many common characteristics, notable differences also exist. In this review, we discuss the heterogeneity of IL-17-producing T cell types focusing on their development, regulation, and function.
Abramson Family Cancer Research Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Jiyeon S
JS
Kim
Martha S
MS
Jordan
D000818:Animals; D015551:Autoimmunity; D016207:Cytokines / Q000378:metabolism; D006801:Humans; D018448:Models, Immunological; D009369:Neoplasms / Q000276:immunology; D011948:Receptors, Antigen, T-Cell / Q000378:metabolism; D015398:Signal Transduction; D058504:Th17 Cells / Q000145:classification* / Q000166:cytology / Q000502:physiology; D014157:Transcription Factors / Q000378:metabolism / Q000502:physiology
D016207:Cytokines; D011948:Receptors, Antigen, T-Cell; D014157:Transcription Factors