Machilusmarin, a new neuroprotective isocoumarin dimer from the stems of Machilus ichangensis Rehd. et Wils.
A new isocoumarin dimer, Machilusmarin (1), was isolated from the stem of Machilus ichangensis Rehd. et Wils., together with two known coumarins, scopoletin (2) and isoscopoletin (3). The structure of Machilusmarin (1) was elucidated by HRMS and NMR spectrums. Machilusmarin (1) showed significant neuroprotective activity against SH-SY5Y human neuroblastoma cells apoptosis induced by hydrogen peroxide at concentrations ranging from 0.625 to 10.0 µg mL(-1).
College of Biological Sciences and Biotechnology, Beijing Forestry University, Beijing, 100083, P.R. China.
Fan
F
Cheng
Zhangshuang
Z
Deng
Zhiyong
Z
Guo
Jianfeng
J
Chen
Kun
K
Zou
D017209:Apoptosis / Q000187:drug effects; D045744:Cell Line, Tumor; D006801:Humans; D006861:Hydrogen Peroxide / Q000494:pharmacology; D019770:Lauraceae / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D009447:Neuroblastoma / Q000378:metabolism; D018696:Neuroprotective Agents / Q000737:chemistry* / Q000494:pharmacology*; D018547:Plant Stems / Q000737:chemistry*
D018696:Neuroprotective Agents; D006861:Hydrogen Peroxide