Recent trends in Cys- and Ser/Thr-based synthetic strategies for the elaboration of peptide constructs.
Recent conceptual advances in the chemical synthesis of peptide constructs are described, encompassing native chemical ligation (i.e. the chemoselective covalent condensation of unprotected peptide segments) and O-, S-acyl isopeptide strategies (i.e. internal O,S-to-N acyl transfer within peptides).
Center for Heterocyclic Compounds, Department of Chemistry, University of Florida, Gainesville, 32611-7200, USA.
Jean-Christophe M
JC
Monbaliu
Alan R
AR
Katritzky
D003545:Cysteine / Q000737:chemistry*; D004951:Esterification; D007097:Imines / Q000737:chemistry; D052578:Ionic Liquids / Q000737:chemistry; D010455:Peptides / Q000138:chemical synthesis* / Q000737:chemistry; D012694:Serine / Q000737:chemistry*; D012997:Solvents / Q000737:chemistry; D013455:Sulfur / Q000737:chemistry; D013912:Threonine / Q000737:chemistry*; D014867:Water / Q000737:chemistry
D007097:Imines; D052578:Ionic Liquids; D010455:Peptides; D012997:Solvents; D014867:Water; D013912:Threonine; D012694:Serine; D013455:Sulfur; D003545:Cysteine