Expression analysis of tumor-related genes involved in critical regulatory pathways in schwannomas.
OBJECTIVE
Gene expression array analysis is providing key data on the potential candidate genes and biological pathways involved in schwannoma origin and development. In this way we performed expression array studies on tumor-related genes in schwannomas.


METHODS
The GE Array Q Series HS-006 (SuperArray, Bethesda, MD, USA) was used to determine the expression levels of 96 genes corresponding to 6 primary biological regulatory pathways in a series of 23 schwannomas.


RESULTS
We identified 15 genes down-regulated, primarily corresponding to signal transduction functions, and 26 genes up-regulated, most frequently involving cell adhesion functions.


CONCLUSIONS
In addition to the NF2 inactivation (considered as an early step), variations of other biological regulatory pathways might play a key role in schwannoma.
Unidad de Investigación, IdiPAz, Hospital Universitario La Paz, Paseo de la Castellana 261, 28046, Madrid, Spain. miguel.torres@idipaz.es
Miguel
M
Torres-Martín
Victor
V
Martinez-Glez
Carolina
C
Peña-Granero
Luis
L
Lassaletta
Alberto
A
Isla
Jose M
JM
de Campos
Giovanny R
GR
Pinto
Rommel R
RR
Burbano
Bárbara
B
Meléndez
Javier S
JS
Castresana
Juan A
JA
Rey
D020869:Gene Expression Profiling; D006801:Humans; D009442:Neurilemmoma / Q000235:genetics* / Q000473:pathology; D020411:Oligonucleotide Array Sequence Analysis