Determining the pharmacokinetics and long-term biodistribution of SiO2 nanoparticles in vivo using accelerator mass spectrometry.
Biodistribution is an important factor in better understanding silica dioxide nanoparticle (SiNP) safety. Currently, comprehensive studies on biodistribution are lacking, most likely due to the lack of suitable analytical methods. Accelerator mass spectrometry was used to investigate the relationship between administered dose, pharmacokinetics (PK), and long-term biodistribution of (14)C-SiNPs in vivo. PK analysis showed that SiNPs were rapidly cleared from the central compartment, were distributed to tissues of the reticuloendothelial system, and persisted in the tissue over the 8 week time course, raising questions about the potential for bioaccumulation and associated long-term effects.
Biosciences and Biotechnology Division, Physical and Life Sciences Directorate, Lawrence Livermore National Laboratory, Livermore, California, USA. malfatti1@llnlgov
Michael A
MA
Malfatti
Heather A
HA
Palko
Edward A
EA
Kuhn
Kenneth W
KW
Turteltaub
D000054:Acceleration; D061605:Administration, Intravenous; D000818:Animals; D002250:Carbon Radioisotopes / Q000737:chemistry; D007700:Kinetics; D008297:Male; D013058:Mass Spectrometry / Q000379:methods*; D053768:Metal Nanoparticles / Q000737:chemistry*; D051379:Mice; D008807:Mice, Inbred BALB C; D036103:Nanotechnology / Q000379:methods; D010316:Particle Size; D012822:Silicon Dioxide / Q000737:chemistry* / Q000493:pharmacokinetics*; D013997:Time Factors; D014018:Tissue Distribution
D002250:Carbon Radioisotopes; D012822:Silicon Dioxide