[Magnesium and the oxidative stress].
Magnesium deficiency has been shown to result in alterations of cellular functions and biological activity of molecules. The review discusses possible relationship between Mg2+ deficiency and development of oxidative stress. Decrease of Mg2+ concentration in tissues and blood is accompanied with elevation of the oxidative stress markers, including products of the oxidative modification of lipids, proteins and DNA. The reduction in antioxidant defenses is synchronous with oxidative stress markers elevation. Different mechanisms including systemic reactions (hyperactivation of inflammation and endothelial dysfunction) and cellular changes (mitochondrial dysfunction and excessive production of fatty acids) are supposed to be involved in development and maintenance of the oxidative stress due to Mg2+ deficiency. Therefore the facts consolidated into the review evidence clear relation between Mg2+ deficiency and the oxidative stress development.
A A
AA
Spasov
A A
AA
Zheltova
M V
MV
Kharitonov
D000818:Animals; D000975:Antioxidants / Q000378:metabolism; D004727:Endothelium / Q000378:metabolism / Q000503:physiopathology; D006801:Humans; D007249:Inflammation / Q000378:metabolism / Q000503:physiopathology; D015227:Lipid Peroxidation; D008274:Magnesium / Q000378:metabolism*; D008275:Magnesium Deficiency / Q000378:metabolism*; D008928:Mitochondria / Q000378:metabolism / Q000473:pathology; D010084:Oxidation-Reduction; D018384:Oxidative Stress; D017382:Reactive Oxygen Species / Q000378:metabolism
D000975:Antioxidants; D017382:Reactive Oxygen Species; D008274:Magnesium