High frequency of herpesvirus-specific clonotypes in the human T cell repertoire can remain stable over decades with minimal turnover.
High-throughput T cell receptor sequencing on sequentially banked blood samples from healthy individuals has shown that high-frequency clonotypes can remain relatively stable for up to 18 years, with minimal inflation, deflation, or turnover. These populations included T cell expansions specific for Epstein-Barr virus. Thus, in spite of exposure to a barrage of microorganisms over the course of life, the dominant clonotypes in the mature peripheral T cell repertoire can alter surprisingly little.
Australian Centre for Vaccine Development, Queensland Institute of Medical Research, Brisbane, Australia.
M A
MA
Neller
J M
JM
Burrows
M J
MJ
Rist
J J
JJ
Miles
S R
SR
Burrows
D000328:Adult; D000368:Aged; D000595:Amino Acid Sequence; D001782:Blood Donors; D014644:Genetic Variation; D006801:Humans; D008297:Male; D008875:Middle Aged; D008969:Molecular Sequence Data; D011948:Receptors, Antigen, T-Cell / Q000235:genetics*; D011991:Receptors, Virus / Q000235:genetics*; D017422:Sequence Analysis, DNA; D013601:T-Lymphocytes / Q000166:cytology* / Q000502:physiology; D013997:Time Factors
D011948:Receptors, Antigen, T-Cell; D011991:Receptors, Virus