Malignant ovarian Sertoli-Leydig cell tumor localized with selective ovarian vein sampling.
Sertoli-Leydig cell tumors (SLCT) are rare, comprising less than 0.5% of ovarian neoplasms. They are most often diagnosed in premenopausal women and may produce androgens, resulting in hirsuitism, voice deepening, frontal balding, terminal hair growth, and clitoromegaly. SLCT are malignant in 15%-20% of cases. We discuss a 25-year-old patient with persistent hyperandrogenemia. Noninvasive imaging cannot conclusively differentiate between SCLT and other diagnoses such as polycystic ovary syndrome, ovarian hyperthecosis, idiopathic hyperandrogenism, idiopathic hirsuitism, and 21-hydroxylase-deficient nonclassic adrenal hyperplasia. Selective ovarian vein sampling revealed a 15-fold greater testosterone production from the right ovary compared with the left, which guided appropriate surgical management.
Department of Obstetrics and Gynecology, University of British Columbia, Vancouver, British Columbia, Canada. caitlinmhdunne@yahoo.ca
Caitlin
C
Dunne
Jon C
JC
Havelock
D000328:Adult; D000735:Androstenedione / Q000097:blood*; D003937:Diagnosis, Differential; D005260:Female; D006628:Hirsutism / Q000209:etiology; D006801:Humans; D010051:Ovarian Neoplasms / Q000097:blood / Q000150:complications / Q000175:diagnosis* / Q000601:surgery; D010053:Ovary / Q000098:blood supply; D011085:Polycystic Ovary Syndrome / Q000097:blood / Q000150:complications; D018310:Sertoli-Leydig Cell Tumor / Q000097:blood / Q000150:complications / Q000175:diagnosis* / Q000601:surgery; D013739:Testosterone / Q000097:blood*; D014680:Veins; D014770:Virilism / Q000209:etiology
D013739:Testosterone; D000735:Androstenedione