Antiproliferative activity of salinomycin and its derivatives.
Antiproliferative activity of seven amides and one benzotriazole ester derivative of salinomycin, a polyether ionophore antibiotic, with recently reported antibacterial activity, are herein described. Salinomycin and the majority of derivatives exhibit potent antiproliferative activity against the drug-resistant cancer cell lines. Moreover almost all derivatives show stronger activity against LoVo/DX cell line than that of unmodified salinomycin.
Faculty of Chemistry, Adam Mickiewicz University, Grunwaldzka 6, 60-780 Poznan, Poland. adhucz@amu.edu.pl
Adam
A
Huczyński
Jan
J
Janczak
Michał
M
Antoszczak
Joanna
J
Wietrzyk
Ewa
E
Maj
Bogumil
B
Brzezinski
D000577:Amides / Q000737:chemistry; D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000633:toxicity; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D018360:Crystallography, X-Ray; D019008:Drug Resistance, Neoplasm / Q000187:drug effects; D018922:HL-60 Cells; D006801:Humans; D008968:Molecular Conformation; D011714:Pyrans / Q000138:chemical synthesis / Q000737:chemistry* / Q000633:toxicity; D013329:Structure-Activity Relationship; D014230:Triazoles / Q000737:chemistry; D000095662:Polyether Polyketides
D000577:Amides; D000970:Antineoplastic Agents; D011714:Pyrans; D014230:Triazoles; C010327:salinomycin; D000095662:Polyether Polyketides; C012771:benzotriazole