Molecular mechanisms of garlic-derived allyl sulfides in the inhibition of skin cancer progression.
Skin cancer is a serious concern whose incidence is increasing at an alarming rate. Allyl sulfides-i.e., sulfur metabolites in garlic oil-have been demonstrated to have anticancer activity against several cancer types, although the mechanisms underlying these effects remain enigmatic. Our previous study showed that diallyl trisulfide (DATS) is more potent than mono- and disulfides against skin cancer. DATS inhibits cell growth of human melanoma A375 cells and basal cell carcinoma (BCC) cells by increasing the levels of intracellular reactive oxygen species (ROS) and DNA damage and by inducing G2/M arrest, endoplasmic reticulum (ER) stress, and mitochondria-mediated apoptosis, including the caspase-dependent and -independent pathways. This short review focuses on the molecular mechanisms of garlic-derived allyl sulfides on skin cancer prevention.
Institute of Food Science and Technology, National Taiwan University, Taipei, ROC.
Hsiao-Chi
HC
Wang
Jung
J
Pao
Shuw-Yuan
SY
Lin
Lee-Yan
LY
Sheen
D000498:Allyl Compounds / Q000494:pharmacology* / Q000627:therapeutic use; D000818:Animals; D016588:Anticarcinogenic Agents / Q000494:pharmacology / Q000627:therapeutic use; D000972:Antineoplastic Agents, Phytogenic / Q000494:pharmacology* / Q000627:therapeutic use; D017209:Apoptosis / Q000187:drug effects; D004249:DNA Damage / Q000187:drug effects; D018450:Disease Progression; D059865:Endoplasmic Reticulum Stress / Q000187:drug effects; D016195:G2 Phase / Q000187:drug effects; D005737:Garlic / Q000737:chemistry*; D006801:Humans; D008545:Melanoma / Q000188:drug therapy / Q000517:prevention & control / Q000556:secondary; D010938:Plant Oils / Q000737:chemistry; D018517:Plant Roots / Q000737:chemistry*; D017382:Reactive Oxygen Species / Q000037:antagonists & inhibitors / Q000378:metabolism; D012878:Skin Neoplasms / Q000188:drug therapy* / Q000517:prevention & control; D013440:Sulfides / Q000494:pharmacology* / Q000627:therapeutic use
D000498:Allyl Compounds; D016588:Anticarcinogenic Agents; D000972:Antineoplastic Agents, Phytogenic; D010938:Plant Oils; D017382:Reactive Oxygen Species; D013440:Sulfides; C038491:allyl sulfide