Leptin to adiponectin ratio as a useful predictor for cardiac syndrome X.
OBJECTIVE
The role of adipokines in the development of cardiac syndrome X (CSX) remains unknown.


METHODS
Fifty-nine CSX subjects were retrospectively enrolled from our catheterization databank. Another 54 subjects with valvular heart disease or arrhythmia served as controls. Adipokines were measured by ELISA tests.


RESULTS
The CSX had lower circulating adiponectin but higher leptin and higher leptin/adiponectin ratio (×1000) (3.78 ± 4.96 vs. 2.14 ± 5.67, p < 0.001) than those of the controls. In a multivariate analysis, a higher leptin/adiponectin ratio was a predictor of CSX, while insulin-resistance index was not.


CONCLUSIONS
Adipokines may be implicated in the pathogenesis of CSX.
Cardiovascular Center, Taichung Veterans General Hospital, Taichung, Taiwan.
Ying-Chieh
YC
Liao
Kae-Woei
KW
Liang
Wen-Jane
WJ
Lee
Wen-Lieng
WL
Lee
I-Te
IT
Lee
Jun-Sing
JS
Wang
Chih-Tai
CT
Ting
Wayne H-H
WH
Sheu
D052242:Adiponectin / Q000097:blood*; D000368:Aged; D005260:Female; D006801:Humans; D007333:Insulin Resistance; D020738:Leptin / Q000097:blood*; D008297:Male; D017566:Microvascular Angina / Q000097:blood* / Q000209:etiology; D008875:Middle Aged; D012189:Retrospective Studies
D052242:Adiponectin; D020738:Leptin