[Keap1 expression for predicting the chemoresistance and prognosis of advanced non-small cell lung cancer].
OBJECTIVE
It has been proven that Kelch-like ECH-associated protein 1 (Keap1) expression was correlated with the chemoresistance of platinum drugs. The aim of this study is to investigate the protein expression levels of Keap1 in non-small cell lung cancer (NSCLC) patients as well as to correlate its expression with the response rate (RR), progression-free survival (PFS), and overall survival (OS) of patients treated with platinum-based first-line chemotherapy.


METHODS
The immunohistochemical analysis of Keap1 expression was performed using tumor samples from 50 patients with stage III or IV NSCLC.


RESULTS
The high expression ratio of Keap1 was 26.0%. The Keap1 expression was significantly correlated with the RR and PFS after platinum-based chemotherapy (P<0.05) but not with the gender, age, smoking, pathology type, differentiation, metastasis, and OS (P>0.05). The PFS was significantly longer in patients with high Keap1 expression than in those with low/negative expression (P=0.002). Furthermore, the level of Keap1 expression was an independent predictive factor of PFS after platinum-based first-line chemotherapy (P=0.007).


CONCLUSIONS
The expression of Keap1 was significantly correlated with the RR and PFS of platinum-based first-line chemotherapy. Therefore, Keap1 may be a useful biomarker for predicting the chemosensitivity of patients with advanced-stage NSCLC.
Department of Oncology and Radiation Sickness, Cancer Center, Peking University Third Hospital, Beijing 100191, China.
Baoshan
B
Cao
Xiang
X
Zhu
Sen
S
Chen
Yu
Y
Xiao
Li
L
Liang
D000368:Aged; D000970:Antineoplastic Agents / Q000494:pharmacology / Q000627:therapeutic use; D002289:Carcinoma, Non-Small-Cell Lung / Q000175:diagnosis* / Q000188:drug therapy / Q000378:metabolism* / Q000473:pathology; D019008:Drug Resistance, Neoplasm; D005260:Female; D005500:Follow-Up Studies; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D047908:Intracellular Signaling Peptides and Proteins / Q000378:metabolism*; D000072019:Kelch-Like ECH-Associated Protein 1; D008175:Lung Neoplasms / Q000175:diagnosis* / Q000188:drug therapy / Q000378:metabolism* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D009367:Neoplasm Staging; D011379:Prognosis; D016019:Survival Analysis; D016896:Treatment Outcome
D000970:Antineoplastic Agents; D047908:Intracellular Signaling Peptides and Proteins; C431364:KEAP1 protein, human; D000072019:Kelch-Like ECH-Associated Protein 1