TRIP database 2.0: a manually curated information hub for accessing TRP channel interaction network.
Transient receptor potential (TRP) channels are a family of Ca(2+)-permeable cation channels that play a crucial role in biological and disease processes. To advance TRP channel research, we previously created the TRIP (TRansient receptor potential channel-Interacting Protein) Database, a manually curated database that compiles scattered information on TRP channel protein-protein interactions (PPIs). However, the database needs to be improved for information accessibility and data utilization. Here, we present the TRIP Database 2.0 (http://www.trpchannel.org) in which many helpful, user-friendly web interfaces have been developed to facilitate knowledge acquisition and inspire new approaches to studying TRP channel functions: 1) the PPI information found in the supplementary data of referred articles was curated; 2) the PPI summary matrix enables users to intuitively grasp overall PPI information; 3) the search capability has been expanded to retrieve information from 'PubMed' and 'PIE the search' (a specialized search engine for PPI-related articles); and 4) the PPI data are available as sif files for network visualization and analysis using 'Cytoscape'. Therefore, our TRIP Database 2.0 is an information hub that works toward advancing data-driven TRP channel research.
Department of Physiology and Biomedical Sciences, Seoul National University College of Medicine, Seoul, Korea.
Young-Cheul
YC
Shin
Soo-Yong
SY
Shin
Jung Nyeo
JN
Chun
Hyeon Sung
HS
Cho
Jin Muk
JM
Lim
Hong-Gee
HG
Kim
Insuk
I
So
Dongseop
D
Kwon
Ju-Hong
JH
Jeon
D019295:Computational Biology; D030562:Databases, Protein; D033181:Information Dissemination; D020407:Internet; D060066:Protein Interaction Maps; D012984:Software; D050051:Transient Receptor Potential Channels / Q000378:metabolism* / Q000502:physiology; D014584:User-Computer Interface
D050051:Transient Receptor Potential Channels