Anti-Müllerian hormone level in older women: detection of granulosa cell tumor recurrence.
OBJECTIVE
To determine whether anti-Müllerian hormone (AMH) production resumes during normal late menopausal aging. Anti-Müllerian hormone has been proposed as a specific serum marker for adult granulosa cell tumors.


METHODS
Serum AMH from 21 elderly postmenopausal women (mean age, 77 years) and 9 young women (mean age, 22 years) were measured by ultrasensitive immunoassay.


RESULTS
Both median (0 pmol/L) and mean (0.48 pmol/L) serum AMH values for the elderly women were below the level of detection for the immunoassay kit. Three of the 21 participants had minimally detectable level of AMH (1.13-2.76 pmol/L). The cohort of young women had expected normal values of AMH as measurable by the same immunoassay kit.


CONCLUSIONS
Serum AMH values were negligible for postmenopausal women older than 65 years. This extends the normative data for AMH to 108 years old, providing a reference range for the detection of granulosa cell tumors in postmenopausal women.
Department of Anatomy, Otago School of Medical Sciences, University of Otago, Dunedin, New Zealand.
Yih Harng
YH
Chong
Archibald John
AJ
Campbell
Stephanie
S
Farrand
Ian S
IS
McLennan
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000097:blood*; D054304:Anti-Mullerian Hormone / Q000032:analysis / Q000097:blood*; D015331:Cohort Studies; D055088:Early Detection of Cancer / Q000379:methods / Q000592:standards; D005260:Female; D006106:Granulosa Cell Tumor / Q000097:blood / Q000175:diagnosis* / Q000473:pathology; D006801:Humans; D009364:Neoplasm Recurrence, Local / Q000097:blood / Q000175:diagnosis*; D017698:Postmenopause / Q000097:blood; D011379:Prognosis; D012016:Reference Values; D055815:Young Adult
D054304:Anti-Mullerian Hormone