Histology, anatomy, or geography? Exome sequencing begins to delineate somatic mutational differences in esophageal cancer.
Esophageal carcinoma is composed of squamous cell and adenocarcinoma types, each with geographically distinct incidence. The earliest exome sequences in this disease begin to illuminate the genetic demarcations of these anatomically related cancers.
Department of Medicine, Division of Hematology and Oncology, University of California at San Francisco, San Francisco, California, USA. Eric.Collisson@ucsf.edu
Eric A
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Collisson
Raymond J
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Cho
D000230:Adenocarcinoma / Q000235:genetics* / Q000473:pathology; D001483:Base Sequence; D002294:Carcinoma, Squamous Cell / Q000235:genetics* / Q000473:pathology; D004938:Esophageal Neoplasms / Q000235:genetics* / Q000473:pathology; D059472:Exome; D006258:Head and Neck Neoplasms / Q000235:genetics* / Q000473:pathology; D006801:Humans; D009154:Mutation; D051880:Receptors, Notch / Q000235:genetics*; D017422:Sequence Analysis, DNA; D000077195:Squamous Cell Carcinoma of Head and Neck
D051880:Receptors, Notch