Effects of lipoic acid in an experimentally induced hypertensive and diabetic rat model.
In this study, experimental diabetes and nephrectomy have been applied separately and together in order to investigate the possible therapeutic effects of lipoic acid (LA) on hypertensive and diabetic rat kidneys. Wistar rats were divided into eight groups: control, diabetes mellitus (DM), 5/6 nephrectomy, DM + 5/6 nephrectomy, LA administration, DM + LA treated, 5/6 nephrectomy + LA treated, and DM + 5/6 nephrectomy + LA-treated groups, respectively. Renal damage was evaluated histomorphometrically, ultrastructurally, and biochemically. Our findings supported that diabetes and hypertension together increased the rate of renal injury, and LA had therapeutic effects on hypertensive and diabetic rat kidneys.
Department of Histology and Embryology, Faculty of Medicine, Dokuz Eylul University, Izmir, Turkey. serap.cilaker@deu.edu.tr
Serap Cilaker
SC
Mıcılı
Bekir Uğur
BU
Ergur
Candan
C
Ozoğul
Sülen
S
Sarıoğlu
H Alper
HA
Bağrıyanık
Kazım
K
Tuğyan
Cetin
C
Pekcetin
Ulker
U
Sonmez
Isıl
I
Tekmen
Guven
G
Erbil
Gul Guner
GG
Akdoğan
Doğan
D
Ozyurt
Zisan
Z
Buldan
D000818:Animals; D003921:Diabetes Mellitus, Experimental / Q000139:chemically induced / Q000188:drug therapy*; D003928:Diabetic Nephropathies / Q000517:prevention & control; D004195:Disease Models, Animal; D006973:Hypertension / Q000188:drug therapy* / Q000209:etiology; D008297:Male; D009392:Nephrectomy / Q000009:adverse effects; D051381:Rats; D017208:Rats, Wistar; D013311:Streptozocin / Q000009:adverse effects; D008063:Thioctic Acid / Q000627:therapeutic use*
D013311:Streptozocin; D008063:Thioctic Acid