Therapeutic approaches for spinal cord injury.
This study reviews the literature concerning possible therapeutic approaches for spinal cord injury. Spinal cord injury is a disabling and irreversible condition that has high economic and social costs. There are both primary and secondary mechanisms of damage to the spinal cord. The primary lesion is the mechanical injury itself. The secondary lesion results from one or more biochemical and cellular processes that are triggered by the primary lesion. The frustration of health professionals in treating a severe spinal cord injury was described in 1700 BC in an Egyptian surgical papyrus that was translated by Edwin Smith; the papyrus reported spinal fractures as a "disease that should not be treated." Over the last biological or pharmacological treatment method. Science is unraveling the mechanisms of cell protection and neuroregeneration, but clinically, we only provide supportive care for patients with spinal cord injuries. By combining these treatments, researchers attempt to enhance the functional recovery of patients with spinal cord injuries. Advances in the last decade have allowed us to encourage the development of experimental studies in the field of spinal cord regeneration. The combination of several therapeutic strategies should, at minimum, allow for partial functional recoveries for these patients, which could improve their quality of life.
Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo, Instituto de Ortopedia e Traumatologia (IOT), Grupo de Coluna, São Paulo/SP, Brazil.
Alexandre Fogaça
AF
Cristante
Tarcísio Eloy Pessoa de
TE
Barros Filho
Raphael Martus
RM
Marcon
Olavo Biraghi
OB
Letaif
Ivan Dias da
ID
Rocha
D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D017690:Cell Transplantation; D002490:Central Nervous System; D006801:Humans; D020127:Recovery of Function; D013119:Spinal Cord Injuries / Q000628:therapy*; D058630:Spinal Cord Regeneration
D000305:Adrenal Cortex Hormones