Rosai-Dorfman disease with isolated laryngeal involvement.
Rosai-Dorfman disease is a rare histiocyte disorder that is typically characterized by massive cervical lymphadenopathy. Isolated extranodal involvement is uncommon, and isolated laryngeal involvement is extremely rare. We report an unusual case of Rosai-Dorfman disease with isolated laryngeal involvement that led to recurrent dysphonia and airway obstruction. We discuss the challenges we faced in reaching a correct pathologic diagnosis and in deciding on an appropriate treatment regimen. Based on our experience, we believe that Rosai-Dorfman disease should be considered as a differential diagnosis in patients who present with a recurrent inflammatory (histiocytic) mass lesion of the larynx.
Division of Otolaryngology-Head and Neck Surgery, Department of Surgery, University of Alabama At Birmingham School of Medicine, Birmingham, AL, USA.
Elisa A
EA
Illing
Stacey L
SL
Halum
D000402:Airway Obstruction / Q000209:etiology; D055154:Dysphonia / Q000209:etiology; D005260:Female; D015618:Histiocytosis, Sinus / Q000150:complications / Q000175:diagnosis* / Q000628:therapy; D006801:Humans; D007818:Laryngeal Diseases / Q000150:complications / Q000175:diagnosis* / Q000628:therapy; D008875:Middle Aged