Extremely drug-resistant Salmonella enterica serovar Senftenberg infections in patients in Zambia.
Two cases of extremely drug-resistant Salmonella enterica serovar Senftenberg isolated from patients in Zambia were investigated by utilizing MIC determinations and whole-genome sequencing. The isolates were resistant to, and harbored genes toward, nine drug classes, including fluoroquinolones and extended-spectrum cephalosporins, contained two plasmid replicons, and differed by 93 single-nucleotide polymorphisms.
WHO Collaborating Centre for Antimicrobial Resistance in Food-Borne Pathogens and European Union Reference Laboratory for Antimicrobial Resistance, National Food Institute, Technical University of Denmark, Lyngby, Denmark. rshe@food.dtu.dk
Rene S
RS
Hendriksen
Katrine Grimstrup
KG
Joensen
Chileshe
C
Lukwesa-Musyani
Annie
A
Kalondaa
Pimlapas
P
Leekitcharoenphon
Ruth
R
Nakazwe
Frank M
FM
Aarestrup
Henrik
H
Hasman
James C L
JC
Mwansa
D000328:Adult; D000900:Anti-Bacterial Agents / Q000494:pharmacology; D024901:Drug Resistance, Multiple, Bacterial; D006801:Humans; D008297:Male; D008826:Microbial Sensitivity Tests; D010957:Plasmids; D020641:Polymorphism, Single Nucleotide; D012480:Salmonella Infections / Q000382:microbiology*; D019779:Salmonella enterica / Q000187:drug effects* / Q000235:genetics / Q000302:isolation & purification*; D015024:Zambia
D000900:Anti-Bacterial Agents