Pericentrin in health and disease: Exploring the patchwork of Pericentrin splice variants.
Researchers around the world perform large-scale screens to identify disease-related gene defects in humans. One of the genes of interest is Pericentrin (PCNT), a gene which codes for a large coiled-coil protein with multiple functions in the cell. Recently, we showed that different Pericentrin (Pcnt) splice variants are differentially distributed among sensory tissues of the mouse, emphasizing the importance of a protein's spliceome for the function of a cell.
Department of Biology; Animal Physiology; FAU Erlangen-Nuremberg; Erlangen, Germany.
Johanna
J
Mühlhans
Andreas
A
Gießl