Epulis-like gingival angiosarcoma of the mandible: a case report.
A 55-year-old woman consulted our hospital for an epulis-like small mass in the anterior region of the mandible. A biopsy of the tumor was performed. Histological analysis showed that the tumor consisted of spindle-shaped and polygonal cells with hyperchromatic nuclei, and intracytoplasmic vacuoles and mitotic figures were scattered. Immunohistochemical staining revealed that the tumor cells were positive for factor VIII-related antigen, CD31, αSMA, and vimentin, but negative for pancytokeratins, S100 protein, neuron-specific enolase, and CD56. The Ki-67 labeling index was more than 50%. Based on these findings, a final pathological diagnosis of angiosarcoma was made. The tumor did not invade into the surrounding tissue. The operation was performed with about a 20-mm surgical margin that was negative for tumor invasion. After a 4-year follow-up, no metastatic lesions were found, and the primary site was covered with a partial denture.
Department of Oral and Maxillofacial Surgery, Ehime University Graduate School of Medicine, Toon-city, Ehime Japan. tomoki@m.ehime-u.ac.jp
Tomoki
T
Sumida
Ryuichi
R
Murase
Yohei
Y
Fujita
Akiko
A
Ishikawa
Hiroyuki
H
Hamakawa
D014408:Biomarkers, Tumor / Q000378:metabolism; D005260:Female; D005882:Gingival Diseases / Q000378:metabolism / Q000473:pathology*; D006394:Hemangiosarcoma / Q000378:metabolism / Q000473:pathology* / Q000601:surgery; D006801:Humans; D019394:Ki-67 Antigen / Q000378:metabolism; D008339:Mandibular Neoplasms / Q000378:metabolism / Q000473:pathology* / Q000601:surgery; D008875:Middle Aged; D016896:Treatment Outcome
D014408:Biomarkers, Tumor; D019394:Ki-67 Antigen