A comparison of symptom severity and bolus retention with Chicago classification esophageal pressure topography metrics in patients with achalasia.
OBJECTIVE
We compared findings from timed barium esophagrams (TBEs) and esophageal pressure topography studies among achalasia subtypes and in relation to symptom severity.


METHODS
We analyzed data from 50 patients with achalasia (31 men; age, 20-79 y) who underwent high-resolution manometry (HRM), had TBE after a 200-mL barium swallow, and completed questionnaires that determined Eckardt Scores. Twenty-five patients were not treated, and 25 patients were treated (11 by pneumatic dilation, 14 by myotomy). Nonparametric testing was used to assess differences among groups of treated patients (10 had type 1 achalasia and 15 had type 2 achalasia), and the Pearson correlation was used to assess their relationship.


RESULTS
There were no significant differences in TBE measurements between patient groups. Of the 25 patients who received treatment, 10 had a manometric pattern consistent with persistent achalasia after treatment (6 patients with type 1 and 4 patients with type 2 achalasia), whereas 15 appeared to have resolved the achalasia pattern (peristalsis was absent in 8 patients and weak in 7 patients). The height of the barium column at 5 minutes and Eckardt Scores were reduced significantly in patients who had resolved their achalasia pattern, based on HRM. The integrated relaxation pressure and the TBE column height correlated at 5 minutes (r = 0.422; P < .05).


CONCLUSIONS
Patients who resolved their achalasia pattern, based on HRM, showed improved emptying based on TBE measurements and improved symptom scores. There was no significant difference between patients with type 1 or type 2 achalasia in TBEs. These findings indicate that normalization of the integrated relaxation pressure on HRM is a clinically relevant objective of treatment for achalasia.
Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611-2951, USA.
Frédéric
F
Nicodème
Annemijn
A
de Ruigh
Yinglian
Y
Xiao
Shankar
S
Rajeswaran
Ezra N
EN
Teitelbaum
Eric S
ES
Hungness
Peter J
PJ
Kahrilas
John E
JE
Pandolfino
D000328:Adult; D000368:Aged; D001466:Barium Sulfate; D003287:Contrast Media; D004931:Esophageal Achalasia / Q000175:diagnosis* / Q000503:physiopathology* / Q000628:therapy; D004947:Esophagus / Q000000981:diagnostic imaging / Q000503:physiopathology*; D005260:Female; D006801:Humans; D008297:Male; D008365:Manometry / Q000379:methods; D008875:Middle Aged; D011859:Radiography / Q000379:methods; D016896:Treatment Outcome; D055815:Young Adult
D003287:Contrast Media; D001466:Barium Sulfate