RGMa and RGMb expression pattern during chicken development suggest unexpected roles for these repulsive guidance molecules in notochord formation, somitogenesis, and myogenesis.
BACKGROUND
Repulsive guidance molecules (RGM) are high-affinity ligands for the Netrin receptor Neogenin, and they are crucial for nervous system development including neural tube closure; neuronal and neural crest cell differentiation and axon guidance. Recent studies implicated RGM molecules in bone morphogenetic protein signaling, which regulates a variety of developmental processes. Moreover, a role for RGMc in iron metabolism has been established. This suggests that RGM molecules may play important roles in non-neural tissues.


RESULTS
To explore which tissues and processed may be regulated by RGM molecules, we systematically investigated the expression of RGMa and RGMb, the only RGM molecules currently known for avians, in the chicken embryo.


CONCLUSIONS
Our study suggests so far unknown roles of RGM molecules in notochord, somite and skeletal muscle development.
Universidade Federal de Minas Gerais-Departamento de Morfologia, Belo Horizonte, MG, Brazil. ecjorge@icb.ufmg.br
Erika Cristina
EC
Jorge
Mohi U
MU
Ahmed
Ingo
I
Bothe
Luiz Lehmman
LL
Coutinho
Susanne
S
Dietrich
D000818:Animals; D030161:Avian Proteins / Q000096:biosynthesis* / Q000235:genetics; D019521:Body Patterning / Q000502:physiology*; D002642:Chick Embryo; D002645:Chickens; D058851:GPI-Linked Proteins / Q000096:biosynthesis* / Q000235:genetics; D018507:Gene Expression Regulation, Developmental / Q000502:physiology*; D007501:Iron / Q000378:metabolism*; D024510:Muscle Development / Q000502:physiology*; D018482:Muscle, Skeletal / Q000166:cytology / Q000196:embryology; D009672:Notochord / Q000166:cytology / Q000196:embryology; D019170:Somites / Q000166:cytology / Q000196:embryology*
D030161:Avian Proteins; D058851:GPI-Linked Proteins; D007501:Iron