Meta-analysis demonstrates lack of association of the hOGG1 Ser326Cys polymorphism with bladder cancer risk.
The functional polymorphism Ser326Cys (rs1052133) in  the human 8-oxoguanine DNA glycosylase (hOGG1) gene has been implicated  in bladder cancer risk. However, reports of this association between the  Ser326Cys polymorphism and bladder cancer risk are conflicting. In order to  help clarify this relationship, we made a meta-analysis of seven case-control  studies, summing 2521 cases and 2408 controls. We used odds ratios (ORs) with  95% confidence intervals (95%CIs) to assess the strength of the association.  Overall, no significant association between the hOGG1 Ser326Cys  polymorphism and bladder cancer risk was found for Cys/Cys vs Ser/Ser  (OR = 1.10, 95%CI = 0.74-1.65), Ser/Cys vs Ser/Ser (OR = 1.07, 95%CI =  0.81-1.42), Cys/Cys + Ser/Cys vs Ser/Ser (OR = 1.08, 95%CI = 0.87-1.33),  and Cys/Cys vs Ser/Cys + Ser/Ser (OR = 1.04, 95%CI = 0.65-1.69). Even  when stratified by ethnicity, no significant association was observed. We  concluded that the hOGG1 Ser326Cys polymorphism does not contribute to  susceptibility to bladder cancer.
Department of Molecular and Genetic Toxicology, Key Laboratory of Modern Toxicology, Ministry of Education, School of Public Health, Nanjing Medical University, Nanjing, China.
D Y
DY
Zhong
H Y
HY
Chu
M L
ML
Wang
L
L
Ma
D N
DN
Shi
Z D
ZD
Zhang
D019943:Amino Acid Substitution / Q000235:genetics*; D045647:DNA Glycosylases / Q000235:genetics*; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006801:Humans; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D017594:Publication Bias; D012307:Risk Factors; D001749:Urinary Bladder Neoplasms / Q000235:genetics*
D045647:DNA Glycosylases; C479058:oxoguanine glycosylase 1, human