Response to 5-Fluorouracil-based chemotherapy in a patient with metastatic colonic-type adenocarcinoma arising in a primary mediastinal teratoma.
Germ cell tumor with somatic malignant transformation is an uncommon phenomenon occurring about 7% of all mediastinal teratomas. Among all transformed component, sarcoma appears to be the most frequent histology, followed by primitive neuroectodermal tumor (PNET) and adenocarcinoma. To our knowledge, there were 3 cases of colonic-type adenocarcinoma arising in a primary teratoma have been reported to date. However, none of them received chemotherapy directed to transformed histology given localized disease at presentation. We, therefore, report here the first case of patient who achieved good response from chemotherapy directed to transformed histology, which confirms the importance of chemotherapy regimen used.
Department of Oncology, Faculty of Medicine and Dentisty and Cross Cancer Institute, University of Alberta, Edmonton, AB, Canada T6G 1Z2 ; Holistic Center for Cancer Study and Care (HOCC-PSU) and Division of Medical Oncology, Department of Internal Medicine, Faculty of Medicine, Prince of Songkla University, Songkhla 90110, Thailand.
Arunee
A
Dechaphunkul
Gilbert
G
Bigras
Michael
M
Sawyer