Synthetic biology triggers new era of antibiotics development.
As a discipline to design and construct organisms with desired properties, synthetic biology has generated rapid progresses in the last decade. Combined synthetic biology with the traditional process, a new universal workflow for drug development has been becoming more and more attractive. The new methodology exhibits more efficient and inexpensive comparing to traditional methods in every aspect, such as new compounds discovery & screening, process design & drug manufacturing. This article reviews the application of synthetic biology in antibiotics development, including new drug discovery and screening, combinatorial biosynthesis to generate more analogues and heterologous expression of biosynthetic gene clusters with systematic engineering the recombinant microbial systems for large scale production.
Key Laboratory of Synthetic Biology, Institute of Plant Physiology and Ecology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 300 Fenglin Road, Shanghai, 200032, China.
Jianfeng
J
Wang
Zhiqiang
Z
Xiong
Hailin
H
Meng
Yiguang
Y
Wang
Yong
Y
Wang
D000818:Animals; D000900:Anti-Bacterial Agents / Q000096:biosynthesis* / Q000627:therapeutic use; D001688:Biological Products / Q000378:metabolism / Q000627:therapeutic use; D055808:Drug Discovery / Q000379:methods*; D004353:Drug Evaluation, Preclinical; D005818:Genetic Engineering / Q000379:methods; D006801:Humans; D058615:Synthetic Biology / Q000379:methods*
D000900:Anti-Bacterial Agents; D001688:Biological Products