Pure protein scaffolds from pickering high internal phase emulsion template.
The formation of hierarchical porous protein scaffolds from oil-in-water (o/w) high internal phase emulsions (HIPEs) stabilized by bovine serum albumin (BSA) protein nanoparticles (Pickering HIPE) is reported. The route consists of three principal steps. First, a stable o/w HIPE stabilized by BSA protein nanoparticles is formulated. Next, crosslinking the dispersed protein nanoparticles gives rise to a gel in the continuous water phase to freeze the emulsion's microstructure. Finally, removal of the oil components and water directly leads to a three dimensional, bimodal meso-macroporous protein scaffold, which is suitable for a wide range of biomedical applications.
Department of Chemistry, The Chinese University of Hong Kong, Shatin, N.T., Hong Kong.
Zifu
Z
Li
Manda
M
Xiao
Jianfang
J
Wang
To
T
Ngai
D000818:Animals; D002417:Cattle; D004655:Emulsions / Q000737:chemistry*; D053758:Nanoparticles / Q000737:chemistry; D016062:Porosity; D012710:Serum Albumin, Bovine / Q000737:chemistry*; D014867:Water / Q000737:chemistry
D004655:Emulsions; D014867:Water; D012710:Serum Albumin, Bovine