Small reactive carbonyl compounds as tissue lipid oxidation products; and the mechanisms of their formation thereby.
Small reactive carbonyl compounds (RCCs) such as formaldehyde, acetaldehyde, acrolein, crotonaldehyde, glyoxal, methylglyoxal, glycolaldehyde, glycidaldehyde, and 2-butene-1,4-dial are involved in carbonyl and oxidative stress-related physiological disorders. While some evidence indicates that lipid oxidation could be an important source of these compounds in vivo, this has sometimes been doubted because the mechanisms of their formation thereby are poorly understood. Here, representative literature supporting the significant formation of these compounds during lipid oxidation under physiologically relevant conditions are highlighted, and the strengths and weaknesses of previously proposed mechanisms of their formation thereby are considered. In addition, based on the current understanding of lipid oxidation chemistry, some new pathways of their formation are suggested. The suggested pathways also generate 4-hydroxy-2-butenal, a precursor of the carcinogen furan, whose endogenous formation in tissues has hitherto not been seriously considered.
Department of Food Science and Technology, Jomo Kenyatta University of Agriculture and Technology, P.O. Box 62000 (00200), Nairobi, Kenya. arnold.onyango@jkuat.ac.ke
Arnold N
AN
Onyango
D000447:Aldehydes / Q000737:chemistry / Q000378:metabolism*; D000818:Animals; D005663:Furans / Q000737:chemistry / Q000378:metabolism; D006801:Humans; D050356:Lipid Metabolism / Q000502:physiology; D015227:Lipid Peroxidation / Q000502:physiology; D015394:Molecular Structure; D018384:Oxidative Stress / Q000502:physiology; D013329:Structure-Activity Relationship
D000447:Aldehydes; D005663:Furans; C039281:furan