Pd-catalyzed Suzuki coupling reaction of chloroalkylidene-β-lactones with LB-Phos as the ligand.
In this paper, LB-Phos·HBF(4) salt has been applied for the Pd-catalysed Suzuki coupling reactions of optically active (Z)-α-choroalkylidene-β-lactones. Aryl, vinyl, alkyl and heteroaromatic boronic acids may be coupled with optically active β-lactones affording corresponding optically active products highly selectively and efficiently.
Laboratory of Molecular Recognition and synthesis, Department of Chemistry, Zhejiang University, Hangzhou 310027, People's Republic of China.
Pengbin
P
Li
Bo
B
Lü
Chunling
C
Fu
Shengming
S
Ma
D001897:Boronic Acids / Q000737:chemistry*; D002384:Catalysis; D007783:Lactones / Q000138:chemical synthesis* / Q000737:chemistry; D008024:Ligands; D008958:Models, Molecular; D015394:Molecular Structure; D009942:Organometallic Compounds / Q000737:chemistry*; D010165:Palladium / Q000737:chemistry*
D001897:Boronic Acids; D007783:Lactones; D008024:Ligands; D009942:Organometallic Compounds; D010165:Palladium