Glia: regulating synaptogenesis from multiple directions.
Glia cells are uniquely positioned at synapses, contacting pre- and post-synaptic terminals. At the Drosophila neuromuscular junction, a novel glia-derived TGF-β ligand has been found that modulates a retrograde synaptogenic signal.
Department of Neurobiology and Department of Neurology, F.M. Kirby Neurobiology Center, Children's Hospital, Harvard Medical School, Boston, MA 02115, USA.
Allison Rosen
AR
Bialas
Beth
B
Stevens
D000818:Animals; D004330:Drosophila / Q000378:metabolism*; D029721:Drosophila Proteins / Q000378:metabolism*; D009457:Neuroglia / Q000378:metabolism*; D009469:Neuromuscular Junction / Q000254:growth & development*; D013569:Synapses / Q000502:physiology*; D016212:Transforming Growth Factor beta / Q000378:metabolism*
D029721:Drosophila Proteins; D016212:Transforming Growth Factor beta; C089440:gbb protein, Drosophila; C415352:mav protein, Drosophila