Hedgehog signaling and the cilium: in the zone.
Hedgehog signaling is transduced at the primary cilium, but the precise mechanisms underlying this action are not clear. In this issue of Developmental Cell, Dorn and colleagues (2012) describe a novel mechanism for control of Hedgehog signaling by Evc proteins within the primary cilium.
Department of Genetics, University of Georgia, Athens, GA 30606, USA. jeggensc@uga.edu
Jonathan
J
Eggenschwiler