Interrelationships between tooth properties and biochemical bone turnover markers investigated on six-month-old pig model.
The aim of the study was to determine interrelationships between bone tissue metabolism indices and morphological, biomechanical and densitometric properties of hard dental tissues. First primary maxillary incisor from 6-month-old pigs (N=27) was evaluated in terms of weight and length. Mean volumetric tooth mineral density, total tooth volume, enamel total volume, enamel volumetric mineral density, dentine total volume and dentine volumetric mineral density were estimated with the use of quantitative computed tomography and micro computed tomography techniques. Tooth mineral density and tooth mineral content were evaluated with the use of dual-energy X-ray absorptiometry. Microhardness of enamel was measured using Vicker's test. Evaluations of total calcium, ionized calcium, magnesium, phosphorus, alkaline phosphatase, bone alkaline phosphatase, osteocalcin, C-terminal telopeptide of type-I collagen (CTX), insulin-like growth factor-1, growth hormone and parathyroid hormone were performed in plasma and serum samples. Pearson's correlation coefficients were determined between all the investigated variables, and P<0.05 was considered as statistically significant. The obtained results have shown mainly mutual dependences between biochemical indicators of bone metabolism. Evaluation of CTX concentration in serum of pigs has shown the highest predictive value in relation to morphological, densitometric and biomechanical properties of teeth.
Department of Conservative Dentistry and Endodontics, Medical University in Lublin, ul. Karmelicka 7, 20-081 Lublin, Poland.
Barbara
B
Tymczyna
Marcin R
MR
Tatara
Witold
W
Krupski
Monika
M
Tymczyna-Sobotka
Teresa
T
Bachanek
D000818:Animals; D015415:Biomarkers / Q000097:blood*; D001696:Biomechanical Phenomena; D001842:Bone and Bones / Q000378:metabolism*; D002118:Calcium / Q000097:blood; D024042:Collagen Type I / Q000097:blood / Q000378:metabolism; D013006:Growth Hormone; D007334:Insulin-Like Growth Factor I / Q000378:metabolism; D008274:Magnesium / Q000097:blood; D008297:Male; D015675:Osteocalcin / Q000097:blood; D010455:Peptides / Q000097:blood / Q000378:metabolism; D010758:Phosphorus / Q000097:blood; D013552:Swine / Q000502:physiology*; D014070:Tooth / Q000502:physiology*
D015415:Biomarkers; D024042:Collagen Type I; D010455:Peptides; C052929:collagen type I trimeric cross-linked peptide; D015675:Osteocalcin; D010758:Phosphorus; D007334:Insulin-Like Growth Factor I; D013006:Growth Hormone; D008274:Magnesium; D002118:Calcium