Association between serum ceruloplasmin levels and arterial stiffness in Korean men with type 2 diabetes mellitus.
BACKGROUND
Increased oxidative stress contributes to the development of arterial stiffness. Arterial stiffness, as measured by brachial-ankle pulse wave velocity (baPWV), has been known to be correlated with oxidative stress. Serum ceruloplasmin (CP), a copper-carrying protein, may indicate the overall level of oxidative stress in the body. The present study investigated whether serum CP levels are associated with baPWV in Korean men with type 2 diabetes mellitus (DM).


METHODS
Serum CP levels and conventional risk factors were measured in 760 Korean men with type 2 DM. Arterial stiffness was assessed by baPWV obtained with an automatic device (model VP-1000; Colin, Komaki, Japan).


RESULTS
Correlation analysis indicated a significant positive association between serum CP and baPWV (r = 0.109, P = 0.003). Age-adjusted baPWV increased gradually according to serum CP quartiles (Q1, 1,500.3 ± 18.4 cm/s; Q2, 1,511.6 ± 17.8 cm/s; Q3, 1,551.8 ± 17.9 cm/s; Q4, 1,622.1 ± 17.8 cm/s; P for trend < 0.001). Multivariate linear regression analysis showed that serum CP was independently associated with baPWV in various models.


CONCLUSIONS
A positive relationship was identified between CP and baPWV in adult male subjects with type 2 DM, which was independent of conventional cardiovascular risk factors. Further studies are needed to confirm whether CP contributes to the pathogenesis of increased arterial stiffness in subjects with type 2 DM.
Department of Internal Medicine, University of Ulsan College of Medicine, Seoul, Korea.
Min Jung
MJ
Lee
Chang Hee
CH
Jung
Jenie Yoonoo
JY
Hwang
Mi Seon
MS
Shin
Ji Hee
JH
Yu
Woo Je
WJ
Lee
Joong-Yeol
JY
Park
D055109:Ankle Brachial Index; D044466:Asian People; D050197:Atherosclerosis / Q000097:blood* / Q000453:epidemiology* / Q000503:physiopathology; D015415:Biomarkers / Q000097:blood; D001786:Blood Glucose; D001794:Blood Pressure; D015992:Body Mass Index; D002570:Ceruloplasmin / Q000378:metabolism*; D008076:Cholesterol, HDL / Q000097:blood; D003924:Diabetes Mellitus, Type 2 / Q000097:blood* / Q000453:epidemiology / Q000503:physiopathology; D003925:Diabetic Angiopathies / Q000097:blood* / Q000453:epidemiology* / Q000503:physiopathology; D005215:Fasting / Q000097:blood; D006442:Glycated Hemoglobin / Q000378:metabolism; D006801:Humans; D008055:Lipids / Q000097:blood; D008297:Male; D008875:Middle Aged; D018384:Oxidative Stress; D011673:Pulsatile Flow; D056910:Republic of Korea / Q000453:epidemiology; D012307:Risk Factors; D059289:Vascular Stiffness
D015415:Biomarkers; D001786:Blood Glucose; D002570:Ceruloplasmin; D008076:Cholesterol, HDL; D006442:Glycated Hemoglobin; D008055:Lipids; C517652:hemoglobin A1c protein, human