Biology of circulating nucleic acids and possible roles in diagnosis and treatment in diabetes and cancer.
The presence of DNA and RNA circulating in human plasma and serum is described. The possible sources of the DNA/RNA in blood, their ability to enter other cells and to express in the recipient cells are discussed and the relationship with metastases considered. The possible role(s) of the DNA/RNA in clinical diagnosis, in monitoring treatment and in prognosis are considered for diabetes and oncology.
Anatomy & Human Sciences, King's College London, London Bridge, London SE1 1UL, UK. pgahan@aol.com
Peter B
PB
Gahan
D000818:Animals; D004247:DNA / Q000097:blood* / Q000378:metabolism; D003920:Diabetes Mellitus / Q000175:diagnosis / Q000503:physiopathology / Q000628:therapy*; D006801:Humans; D009362:Neoplasm Metastasis; D009369:Neoplasms / Q000175:diagnosis / Q000473:pathology / Q000628:therapy*; D011379:Prognosis; D012313:RNA / Q000097:blood* / Q000378:metabolism
D012313:RNA; D004247:DNA