In vitro percutaneous absorption of ketoprofen and testosterone: comparison of pluronic lecithin organogel vs. pentravan cream.
An in vitro human percutaneous absorption study was conducted to assess the delivery of ketoprofen and testosterone from two base formulations, a Pluronic lecithin organogel and Pentravan Cream. Each formulation was applied to ex vivo human trunk skin (from three skin donors) on triplicate sections mounted onto Franz Diffusion Cells. Following a 5-mcL/cm2 applied dose, serial dermal receptor solutions were collected over 48 hours. For both compounds, a greater rate and extent of absorption was found from the Pentravan formulation than from the Pluronic lecithin organogel formulation: 3.8-fold greater for ketoprofen, 1.7-fold greater for testosterone, for amount absorbed.
Cetero Research, Fargo, North Dakota 58104, USA.
Paul A
PA
Lehman
Sam G
SG
Raney
D000279:Administration, Cutaneous; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000493:pharmacokinetics*; D005260:Female; D005782:Gels; D006801:Humans; D007660:Ketoprofen / Q000008:administration & dosage / Q000493:pharmacokinetics*; D054709:Lecithins / Q000008:administration & dosage; D008297:Male; D008875:Middle Aged; D009824:Ointments; D012869:Skin Absorption; D013739:Testosterone / Q000008:administration & dosage / Q000493:pharmacokinetics*
D000894:Anti-Inflammatory Agents, Non-Steroidal; D005782:Gels; D054709:Lecithins; D009824:Ointments; D013739:Testosterone; D007660:Ketoprofen