Antifungal activity of hydrochloride salts of tylophorinidine and tylophorinine.
The antimicrobial efficacy of two phenanthroindolizidine alkaloids, tylophorinidine hydrochloride (TdnH) and tylophorinine hydrochloride (TnnH), isolated from the plant Tylophora indica (local name, Antamul) was evaluated. These were screened for in vitro antifungal and antibacterial activities. Both compounds exhibited potent antifungal activity displaying minimum inhibitory concentrations (MIC) in the range of 2-4 microg/mL for TdnH and 0.6-2.5 microg/mL for TnnH against Candida species.
Special Projects Analytical Chemistry, Piramal Healthcare Limited, Mumbai-400063, India.
Mini
M
Dhiman
Rajashri R
RR
Parab
Sreedharannair L
SL
Manju
Dattatraya C
DC
Desai
Girish B
GB
Mahajan
D000470:Alkaloids / Q000494:pharmacology*; D000935:Antifungal Agents / Q000494:pharmacology*; D054836:Indolizidines; D007546:Isoquinolines / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D010616:Phenanthrenes; D010936:Plant Extracts / Q000494:pharmacology; D031110:Tylophora / Q000737:chemistry
D000470:Alkaloids; D000935:Antifungal Agents; D054836:Indolizidines; D007546:Isoquinolines; D010616:Phenanthrenes; D010936:Plant Extracts; C575993:tylophorinine; C032276:tylophorinidine