Nuclear phospholipase C β1 signaling, epigenetics and treatments in MDS.
Myelodysplastic syndromes (MDS), clonal hematopoietic stem-cell disorders mainly affecting older adult patients, show ineffective hematopoiesis in one or more of the lineages of the bone marrow. Most MDS are characterized by anemia, and a number of cases progresses to acute myeloid leukemia (AML). Indeed, the molecular mechanisms underlying the MDS evolution to AML are still unclear, even though the nuclear signaling elicited by PI-PLCβ1 has been demonstrated to play an important role in the control of the balance between cell cycle progression and apoptosis in MDS cells. Here we review both the role of epigenetic therapy on PI-PLCβ1 promoter and the changes in PI-PLCβ1 expression in MDS patients treated for anemia.
Cellular Signalling Laboratory, Department of Human Anatomical Sciences, University of Bologna, Bologna, Italy. matilde.follo@unibo.it
Matilde Y
MY
Follo
Sandra
S
Marmiroli
Irene
I
Faenza
Roberta
R
Fiume
Giulia
G
Ramazzotti
Alberto M
AM
Martelli
Pietro
P
Gobbi
James A
JA
McCubrey
Carlo
C
Finelli
Francesco A
FA
Manzoli
Lucio
L
Cocco
D017209:Apoptosis / Q000187:drug effects; D001853:Bone Marrow / Q000187:drug effects / Q000378:metabolism / Q000473:pathology; D002453:Cell Cycle / Q000187:drug effects; D002467:Cell Nucleus / Q000187:drug effects / Q000235:genetics / Q000378:metabolism; D044127:Epigenesis, Genetic / Q000187:drug effects; D004921:Erythropoietin / Q000627:therapeutic use; D006412:Hematopoietic Stem Cells / Q000187:drug effects / Q000378:metabolism / Q000473:pathology; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000188:drug therapy / Q000209:etiology / Q000235:genetics* / Q000473:pathology; D009190:Myelodysplastic Syndromes / Q000150:complications / Q000188:drug therapy / Q000235:genetics* / Q000473:pathology; D010716:Phosphatidylinositols / Q000378:metabolism; D054799:Phospholipase C beta / Q000235:genetics* / Q000378:metabolism; D011401:Promoter Regions, Genetic; D015398:Signal Transduction / Q000187:drug effects
D010716:Phosphatidylinositols; D004921:Erythropoietin; C518033:PLCB1 protein, human; D054799:Phospholipase C beta