Inflammation-based prognostic score as a predictor of postoperative gastric cancer recurrence.
OBJECTIVE
The aim of our study was to determine whether an inflammation-based prognostic score predicted tumor aggressiveness and disease-free survival (DFS).


METHODS
We retrospectively reviewed 197 patients with locally advanced gastric cancer. The preoperative inflammation-based score was calculated as follows: patients with elevated C-reactive protein (>0.5 mg/dl) and hypoalbuminemia (<3.5 g/dl) were allocated a score of 2, and patients with one or no abnormal value were allocated a score of 1 or 0, respectively.


RESULTS
The inflammation-based prognostic score was significantly associated with tumor size and lymph node metastasis. The association between inflammation-based prognostic score and DFS was evaluated by univariate and multivariate Cox proportional hazard models. In multivariate analyses, an elevated inflammation-based prognostic score was associated with significantly worse DFS.


CONCLUSIONS
Preoperative inflammation-based prognostic score is a potential marker for recurrence after curative gastrectomy.
Department of Gastrointestinal and Pediatric Surgery, Mie University Graduate School of Medicine, Tsu, Mie, Japan. ya-mohri@clin.medic.mie-u.ac.jp
Yasuhiko
Y
Mohri
Koji
K
Tanaka
Masaki
M
Ohi
Yuji
Y
Toiyama
Hiromi
H
Yasuda
Yasuhiro
Y
Inoue
Keiichi
K
Uchida
Masato
M
Kusunoki
D000368:Aged; D002097:C-Reactive Protein / Q000032:analysis; D002272:Carcinoembryonic Antigen / Q000097:blood; D018572:Disease-Free Survival; D005260:Female; D005743:Gastrectomy / Q000379:methods; D006801:Humans; D034141:Hypoalbuminemia / Q000097:blood; D007249:Inflammation / Q000097:blood*; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000097:blood* / Q000401:mortality; D011379:Prognosis; D012189:Retrospective Studies; D013274:Stomach Neoplasms / Q000097:blood* / Q000401:mortality / Q000601:surgery; D047368:Tumor Burden
D002272:Carcinoembryonic Antigen; D002097:C-Reactive Protein