Treatment of gingival recession defects with a coronally advanced flap and a xenogeneic collagen matrix: a multicenter randomized clinical trial.
OBJECTIVE
To evaluate the clinical outcomes of the use of a xenogeneic collagen matrix (CM) in combination with the coronally advanced flap (CAF) in the treatment of localized recession defects.


METHODS
In a multicentre single-blinded, randomized, controlled, split-mouth trial, 90 recessions (Miller I, II) in 45 patients received either CAF + CM or CAF alone.


RESULTS
At 6 months, root coverage (primary outcome) was 75.29% for test and 72.66% for control defects (p = 0.169), with 36% of test and 31% of control defects exhibiting complete coverage. The increase in mean width of keratinized tissue (KT) was higher in test (from 1.97 to 2.90 mm) than in control defects (from 2.00 to 2.57 mm) (p = 0.036). Likewise, test sites had more gain in gingival thickness (GT) (0.59 mm) than control sites (0.34 mm) (p = 0.003). Larger (≥3 mm) recessions (n = 35 patients) treated with CM showed higher root coverage (72.03% versus 66.16%, p = 0.043), as well as more gain in KT and GT.


CONCLUSIONS
CAF + CM was not superior with regard to root coverage, but enhanced gingival thickness and width of keratinized tissue when compared with CAF alone. For the coverage of larger defects, CAF + CM was more effective.
Department of Periodontology, University of Bonn, Bonn, Germany. jepsen@uni-bonn.de
Karin
K
Jepsen
Søren
S
Jepsen
Giovanni
G
Zucchelli
Martina
M
Stefanini
Massimo
M
de Sanctis
Nicola
N
Baldini
Björn
B
Greven
Bernd
B
Heinz
Jan
J
Wennström
Björn
B
Cassel
Fabio
F
Vignoletti
Mariano
M
Sanz
D000328:Adult; D003094:Collagen / Q000627:therapeutic use*; D003238:Connective Tissue / Q000637:transplantation*; D005109:Extracellular Matrix / Q000637:transplantation*; D005260:Female; D005889:Gingival Recession / Q000601:surgery*; D006801:Humans; D007633:Keratins; D008297:Male; D008875:Middle Aged; D016037:Single-Blind Method; D018709:Statistics, Nonparametric; D013524:Surgical Flaps; D013536:Suture Techniques; D014183:Transplantation, Heterologous
D007633:Keratins; D003094:Collagen