Dental stem cells: dentinogenic, osteogenic, and neurogenic differentiation and its clinical cell based therapies.
Each year approximately $400 billion is spent treating Americans suffering some type of tissue loss or end-stage organ failure. This includes millions of dental and oral craniofacial procedure, ranging from tooth restorations to major reconstruction of facial soft and mineralized tissue. Recently, a population of putative post-natal stem cells in human dental pulp (DPSCs) has been identified within the "cell- rich zone" of dental pulp. The other type of stem cells from human exfoliated deciduous teeth (SHED) was identified to be a population of highly proliferative, clonogenic cells. Dental Pulp Stem Cells (DPSCs) can not only be derived from a very accessible tissue resource like SHED but are also capable of providing enough cells for potential cell-based therapies.
Department of Pedodontics and Preventive Dentistry, Genesis Institute of Dental Sciences and Research, Ferozepur, Punjab, India.
Gurlal Singh
GS
Brar
Ravi Sher Singh
RS
Toor
D018929:Cell Culture Techniques; D003782:Dental Pulp / Q000166:cytology*; D003810:Dentinogenesis / Q000502:physiology*; D006801:Humans; D055495:Neurogenesis / Q000502:physiology*; D010012:Osteogenesis / Q000502:physiology*; D044968:Regenerative Medicine; D033581:Stem Cell Transplantation; D013234:Stem Cells / Q000145:classification / Q000502:physiology*; D023822:Tissue Engineering; D014094:Tooth, Deciduous / Q000166:cytology*