Hypernociception and wound healing after application of cyanoacrylate ester as a tissue adhesive in rats.
OBJECTIVE
The present study assessed and compared postoperative hypernociception and skin healing after cyanoacrylate and classic suture as well as analyzed morphologic features of the tissue repair.


METHODS
The intensity of hypernociception was measured with an electronic pressure-meter test. Rats were given an incised wound in the middle of the palms of the right and left paws. The left side was treated with a silk suture, and the right with cyanoacrylate. Control groups were treated locally with dipyrone or received a systemic pretreatment with valdecoxib.


RESULTS
Cyanoacrylate was associated with less inflammation (first week), and the healing wound site was rich in collagenous extracellular matrix and neovascularization. Dipyrone in combination with cyanoacrylate greatly increased the antinociceptive effect. These results were not repeated after systemic treatment with valdecoxib, suggesting that the antinociceptive effect seen in the tissue adhesive was due to formation of a physical barrier.
School of Dentistry, Department of Basic Science, Fluminense Federal University, Nova Friburgo, Rio de Janeiro, Brazil. etyenedip@vm.uff.br
Etyene Castro
EC
Dip
Diogo
D
Luz
Igor
I
Castro-Silva
Andrea
A
Pires
Alvaro
A
Linhares
Mauro
M
Granjeiro
D000704:Analysis of Variance; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology; D003487:Cyanoacrylates / Q000494:pharmacology*; D052246:Cyclooxygenase 2 Inhibitors / Q000494:pharmacology; D004177:Dipyrone / Q000494:pharmacology; D006652:Histological Techniques; D007555:Isoxazoles / Q000494:pharmacology; D008297:Male; D059225:Nociception / Q000187:drug effects* / Q000502:physiology; D051381:Rats; D017208:Rats, Wistar; D013449:Sulfonamides / Q000494:pharmacology; D013536:Suture Techniques; D014014:Tissue Adhesives / Q000494:pharmacology*; D014945:Wound Healing / Q000187:drug effects* / Q000502:physiology; D000096926:Benzenesulfonamides
D000894:Anti-Inflammatory Agents, Non-Steroidal; D003487:Cyanoacrylates; D052246:Cyclooxygenase 2 Inhibitors; D004177:Dipyrone; D007555:Isoxazoles; D013449:Sulfonamides; D014014:Tissue Adhesives; C406224:valdecoxib; D000096926:Benzenesulfonamides