Descriptive epidemiology of non-syndromic complete atrioventricular canal defects.
BACKGROUND
Complete atrioventricular canal defects (CAVC) are a common heart defect, but few epidemiologic studies have evaluated non-syndromic CAVC. Risk factors for non-syndromic CAVC have not been well established.


METHODS
To assess the relationship between risk for non-syndromic CAVC in offspring and several sociodemographic and reproductive parental factors, including maternal diabetes and obesity, we conducted Poisson regression analyses, using data ascertained through the Texas Birth Defects Registry, a large, population-based birth defects registry. Data were evaluated for 563 non-syndromic cases with CAVC.


RESULTS
Significant associations were observed between non-syndromic CAVC in offspring and maternal pregestational diabetes (adjusted prevalence ratio (aPR) 6.74; 95% confidence interval (CI) 3.67, 12.37), gestational diabetes (aPR 1.69; 95% CI 1.03, 2.79) and obesity (aPR 1.69; 95% CI 1.24, 2.30).


CONCLUSIONS
Our findings add non-syndromic CAVC to the growing list of birth defects that appear to be associated with maternal diabetes and obesity.
Center for Human Genetics, Division of Epidemiology, Human Genetics and Environmental Sciences, University of Texas School of Public Health, Houston, TX 77030 USA.
A J
AJ
Agopian
Mousumi
M
Moulik
Monesha
M
Gupta-Malhotra
Lisa K
LK
Marengo
Laura E
LE
Mitchell
D016640:Diabetes, Gestational / Q000453:epidemiology; D004694:Endocardial Cushion Defects / Q000453:epidemiology*; D005260:Female; D006343:Heart Septal Defects; D006801:Humans; D008297:Male; D017533:Marital Status; D008423:Maternal Age; D009765:Obesity / Q000453:epidemiology; D011247:Pregnancy; D011254:Pregnancy in Diabetics / Q000453:epidemiology; D012042:Registries; D012044:Regression Analysis; D012307:Risk Factors; D012959:Socioeconomic Factors; D013781:Texas / Q000453:epidemiology