A 14-year-old girl with multiple tumors.
Pleomorphic xanthoastrocytoma (PXA) is a rare astrocytic tumor that usually occurs in the superficial cerebral hemispheres of children and young adult and has a favorable prognosis. We report a case of a 14-year-old girl with a recent history of sciatica and ataxic gait. Pre- and post-contrast brain and spinal MRI revealed the presence of multiple solid lesions with a cystic component in the cerebellum and the spinal cord with a concomitant massive leptomeningeal involvement Histological and immunohistochemical findings were concordant with a final diagnosis of WHO grade II PXA. Even the biological indolent PXAs' behavior, this is the third report in the literature of such an unusual multicentric PXA with leptomeningeal dissemination.
Department of Medicine, Surgical Pathology & Cytopathology Unit, University Hospital of Padua, 35100, Padua, Italy.
Marina Paola
MP
Gardiman
Matteo
M
Fassan
Enrico
E
Orvieto
Loredana
L
Iaria
Milena
M
Calderone
Rodica
R
Mardari
Domenico
D
DAavella
Giorgio
G
Perilongo
D000293:Adolescent; D001254:Astrocytoma / Q000473:pathology*; D001932:Brain Neoplasms / Q000473:pathology*; D005260:Female; D006801:Humans; D055756:Meningeal Carcinomatosis / Q000473:pathology*