Inflammatory gene variants and the risk of biliary tract cancers and stones: a population-based study in China.
BACKGROUND
Genetic variants in inflammation-related genes have been associated with biliary stones and biliary tract cancers in previous studies.


METHODS
To follow-up on these findings, we examined 35 single nucleotide polymorphism (SNPs) in 5 genes related to inflammation (IL8, NFKBIL, RNASEL, TNF, and VEGFA) in 456 participants with incident biliary tract cancer cases (262 gallbladder, 141 extrahepatic bile duct, 53 ampulla of Vater), 982 participants with biliary stones, and 860 healthy controls in a population-based case-control study in Shanghai, China.


RESULTS
Suggestive associations were observed for SNPs in VEGFA with biliary stones, IL8 with gallbladder and ampulla of Vater cancers, and RNASEL with ampulla of Vater cancer (false discovery rate≤0.2).


CONCLUSIONS
These findings provide additional support for the role of inflammation in biliary stones and biliary tract cancer risk and need further validation.
Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, 6120 Executive Blvd., , Rockville, MD 20892, USA. felipe.castro@nih.gov
Felipe A
FA
Castro
Jill
J
Koshiol
Ann W
AW
Hsing
Yu-Tang
YT
Gao
Asif
A
Rashid
Lisa W
LW
Chu
Ming-Chang
MC
Shen
Bing-Shen
BS
Wang
Tian-Qua
TQ
Han
Bai-He
BH
Zhang
Shelley
S
Niwa
Kai
K
Yu
Hong
H
Zhang
Stephen
S
Chanock
Gabriella
G
Andreotti
D000368:Aged; D001661:Biliary Tract Neoplasms / Q000235:genetics*; D016022:Case-Control Studies; D002681:China; D004722:Endoribonucleases / Q000235:genetics; D005260:Female; D042882:Gallstones / Q000235:genetics*; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D007249:Inflammation / Q000235:genetics*; D016209:Interleukin-8 / Q000235:genetics; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D042461:Vascular Endothelial Growth Factor A / Q000235:genetics
C508606:CXCL8 protein, human; D016209:Interleukin-8; C467484:VEGFA protein, human; D042461:Vascular Endothelial Growth Factor A; D004722:Endoribonucleases; C031956:2-5A-dependent ribonuclease