Hemorheological changes caused by lead exposure.
Lead is a ubiquitous, biohazardous, and toxic heavy metal that induces a broad range of physiological, biochemical, and behavioral dysfunctions. We investigated the effect of lead on hemorheological characteristics, including deformability and aggregation. We found that red blood cell (RBC) deformability was unaffected at low concentrations of lead-rich plasma, but showed a significant decrease at high concentrations even within 1 h of incubation. In addition, apparent alterations in RBC aggregation were observed with an increase in lead concentration and incubation time. These results highlight the influence of lead on hemorheology and microcirculation.
School of Mechanical Engineering, Korea University, Anam-dong, Seongbuk-gu, Seoul, Korea.
C B
CB
Kim
School of Mechanical Engineering, Korea University, Anam-dong, Seongbuk-gu, Seoul, Korea.
Sehyun
S
Shin
School of Mechanical Engineering, Korea University, Anam-dong, Seongbuk-gu, Seoul, Korea.
Seok-Heung
SH
Song
D004903:Erythrocyte Aggregation / Q000187:drug effects*; D004907:Erythrocyte Deformability / Q000187:drug effects*; D018056:Hemorheology; D006801:Humans; D007854:Lead / Q000097:blood*; D007855:Lead Poisoning / Q000097:blood*; D008297:Male
D007854:Lead