Oligonucleotide-templated chemical reactions: pushing the boundaries of a nature-inspired process.
Widespread in nature, oligonucleotide-templated reactions of phosphodiester bond formation have inspired chemists who are now applying this elegant strategy to the catalysis of a broad range of otherwise inefficient reactions. This review highlights the increasing diversity of chemical reactions that can be efficiently catalysed by an oligonucleotide template, using Watson-Crick base-pairing to bring both reagents in close enough proximity to react, thus increasing significantly their effective molarity. The applications of this elegant concept for nucleic acid sensing and controlled organic synthesis will also be discussed.
Department of Bioengineering, Imperial College London, South Kensington campus, London SW7 2AZ, UK.
Claudia
C
Percivalle
Jean-François
JF
Bartolo
Sylvain
S
Ladame
D020029:Base Pairing; D002384:Catalysis; D005453:Fluorescence; D015394:Molecular Structure; D009696:Nucleic Acids / Q000138:chemical synthesis / Q000737:chemistry; D009841:Oligonucleotides / Q000737:chemistry*; D009942:Organometallic Compounds / Q000138:chemical synthesis / Q000737:chemistry; D010455:Peptides / Q000138:chemical synthesis / Q000737:chemistry; D013698:Templates, Genetic
D009696:Nucleic Acids; D009841:Oligonucleotides; D009942:Organometallic Compounds; D010455:Peptides