[Epigenetics in tumorigenesis: advances and clinical implications].
Cancer is a leading cause of death worldwide and the total number of cases globally keeps increasing. For many years,  cancer has been thought to be caused by a series of DNA sequence alterations and thus is thought to be a "genetic" disease.  However, studies in the last decade, including the large-scale cancer genomics projects, have highlighted the rising importance of  epigenetic regulation in cancer. Here, we review recent advances in understanding how chromatin-based epigenetic regulation  participates in tumorigenesis and discuss the growing implications of these advances for developing novel strategies to prevent,  diagnose, as well as treat cancer.
Department of Lymphoma, Tianjin Medical University Cancer Institute and Hospital, Tianjin, China.
Xian huo
Xh
Wang
Xiu juan
Xj
Zhao
Li hua
Lh
Qiu
Hua qing
Hq
Wang
Xi
X
Wang
D002843:Chromatin / Q000235:genetics* / Q000378:metabolism; D019175:DNA Methylation; D018450:Disease Progression; D044127:Epigenesis, Genetic / Q000235:genetics*; D006657:Histones / Q000378:metabolism; D006801:Humans; D009369:Neoplasms / Q000209:etiology / Q000235:genetics* / Q000503:physiopathology
D002843:Chromatin; D006657:Histones