Regulatory T cells in preeclampsia: some answers, more questions?
This Commentary highlights the article by Hsu et al (in this issue) reporting an enrichment in induced regulatory T cells (iTregs) in normal pregnancy but not in preeclampsia, implicating iTreg defect as central to the pathogenesis of preeclampsia.
Center for Vascular Biology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, USA.
Ana S
AS
Cerdeira
Hernan D
HD
Kopcow
S Ananth
SA
Karumanchi
D000938:Antigen-Presenting Cells / Q000276:immunology*; D015815:Cell Adhesion Molecules / Q000378:metabolism*; D003656:Decidua / Q000276:immunology*; D005260:Female; D006801:Humans; D037181:Lectins, C-Type / Q000378:metabolism*; D011225:Pre-Eclampsia / Q000276:immunology* / Q000473:pathology*; D011247:Pregnancy; D011956:Receptors, Cell Surface / Q000378:metabolism*; D050378:T-Lymphocytes, Regulatory / Q000276:immunology*; D000099215:DC-Specific ICAM-3 Grabbing Nonintegrin
D015815:Cell Adhesion Molecules; D037181:Lectins, C-Type; D011956:Receptors, Cell Surface; D000099215:DC-Specific ICAM-3 Grabbing Nonintegrin