Type I toxin-antitoxin systems in Bacillus subtilis.
Type I toxin-antitoxin (TA) systems are widespread in bacteria and consist of a toxin-encoding mRNA and a partially overlapping antisense RNA that blocks expression of the toxin, either at the level of translation or by mRNA degradation. Four type I toxin families have so far been proposed in B. subtilis based on sequence similarity: TxpA/BsrG, BsrH/BsrE, YonT and YhzE and two (TxpA and BsrG) have been studied in some detail. Here we review what is known about these confirmed and putative toxin-antitoxin families in B. subtilis, their regulatory mechanisms, their potential roles and how they may link to the physiology of the cell.
CNRS UPR 9073 (affiliated with Univ. Paris Diderot, Sorbonne Paris Cité), Institut de Biologie Physico-Chimique, Paris, France.
Sylvain
S
Durand
Natalie
N
Jahn
Ciarán
C
Condon
Sabine
S
Brantl
D000595:Amino Acid Sequence; D000992:Antitoxins / Q000737:chemistry* / Q000235:genetics; D001412:Bacillus subtilis / Q000737:chemistry* / Q000235:genetics; D001426:Bacterial Proteins / Q000737:chemistry / Q000235:genetics; D001427:Bacterial Toxins / Q000737:chemistry* / Q000235:genetics; D002876:Chromosomes, Bacterial / Q000737:chemistry / Q000235:genetics; D015964:Gene Expression Regulation, Bacterial; D005798:Genes, Bacterial; D008969:Molecular Sequence Data; D009690:Nucleic Acid Conformation; D020871:RNA Stability; D016372:RNA, Antisense / Q000737:chemistry; D012329:RNA, Bacterial / Q000737:chemistry* / Q000235:genetics; D012333:RNA, Messenger / Q000737:chemistry / Q000235:genetics; D016415:Sequence Alignment
D000992:Antitoxins; D001426:Bacterial Proteins; D001427:Bacterial Toxins; D016372:RNA, Antisense; D012329:RNA, Bacterial; D012333:RNA, Messenger