Tropisetron, a 5-HT(3) receptor antagonist, enhances object exploration in intact female rats.
The effects of a 5-HT(3) receptor antagonist, tropisetron, on cognitive functions were evaluated using the object-recognition test in estrous (postovulatory) and in diestrous female rats. Recognition was measured by the ability of rats to discriminate between a familiar and a new object in a T-maze after a 3-h delay. Rats from both stages spent equivalent amounts of time exploring the objects on trial 1. Three hours after trial 1, trial 2 (test trial) was initiated. Before the test trial, rats were injected with either saline or 1.5 or 2.5 mg/kg tropisetron. During the test trial, one arm of a T-maze contained an object from trial 1 (familiar) and a new object (novel) was introduced into the other arm. Rats from both stages responded to tropisetron by showing a greater percentage of time exploring the novel object. These findings indicate that tropisetron facilitates cognition in female rats by improving the recognition of familiar information.
School of Law, Case Western Reserve University, Cleveland, OH, USA.
John
J
Sawyer
Emily L
EL
Eaves
Charles J
CJ
Heyser
Sharmin
S
Maswood
D000818:Animals; D003071:Cognition / Q000187:drug effects; D004031:Diestrus / Q000378:metabolism; D004305:Dose-Response Relationship, Drug; D004971:Estrus / Q000378:metabolism; D005106:Exploratory Behavior / Q000187:drug effects*; D005260:Female; D007211:Indoles / Q000008:administration & dosage / Q000494:pharmacology*; D018782:Maze Learning / Q000187:drug effects*; D051381:Rats; D011916:Rats, Inbred F344; D058831:Serotonin 5-HT3 Receptor Antagonists / Q000008:administration & dosage / Q000494:pharmacology*; D013997:Time Factors; D000077526:Tropisetron
D007211:Indoles; D058831:Serotonin 5-HT3 Receptor Antagonists; D000077526:Tropisetron