Recent lipase-catalyzed hydrolytic approaches to pharmacologically important β- and γ-amino acids.
Kinetic and sequential kinetic enzymatic routes for the synthesis of enantiomeric β- and γ-amino acids through enzymatic ring cleavage of the corresponding lactams in organic solvents or solvent-free systems or a supercritical CO(2) medium, and for the enantioselective hydrolysis of the corresponding amino esters in organic solvents are reviewed. In the frame of a practical guide, a simple and rapid GC enantioseparation technique for amino acids, including exact descriptions of selected enzymatic reactions, is additionally presented.
Institute of Pharmaceutical Chemistry, University of Szeged, H-6720 Szeged, Eötvös u. 6, Hungary. forro.eniko@pharm.u-szeged.hu
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D000596:Amino Acids / Q000378:metabolism*; D055162:Biocatalysis; D016956:Burkholderia cepacia / Q000201:enzymology; D002175:Candida / Q000201:enzymology; D006868:Hydrolysis; D007700:Kinetics; D007769:Lactams / Q000737:chemistry / Q000378:metabolism; D008049:Lipase / Q000378:metabolism*; D012997:Solvents / Q000737:chemistry; D013237:Stereoisomerism
D000596:Amino Acids; D007769:Lactams; D012997:Solvents; D008049:Lipase