[Study on the weight-reducing effect of Acer truncatum leave extract in alimentary obesity rat].
OBJECTIVE
To investigate the weight-reducing effect of Acer truncatum leave extract on alimentary obesity rats and its effect on fatty acid synthase (FAS).


METHODS
SPF-grade adult male Wistar rats were fed with high-fat diet and Acer truncatum leave extract (10, 30 and 100 mg/kg BW) was given by gavage once a day for 31 days. Body weight (BW), adipose weight and food consumption were recorded, and the activity of hepatic fatty acid synthase (FAS) was measured.


RESULTS
Compared with the model-control group, body weight, adipose weight and the ratio of adipose weight to body weight were obviously lower in 30 mg/kg BW and 100 mg/kg BW groups (P < 0.01). The activity of hepatic FAS in rats administrated with the extract was markedly lower than the control rats (P < 0.05).


CONCLUSIONS
There might have a function of Acer truncatum leave extract on reducing body weight.
Center for Food and Drug Safety Evaluation of Capital Medical University, Beijing 100069, China. lifanggao@ccmu.edu.cn
Lifang
L
Gao
Lige
L
Cao
Mi
M
Tian
Zhenliang
Z
Chen
D031002:Acer / Q000737:chemistry*; D000818:Animals; D019440:Anti-Obesity Agents; D001835:Body Weight; D059305:Diet, High-Fat; D064429:Fatty Acid Synthases / Q000378:metabolism; D008099:Liver / Q000201:enzymology; D008297:Male; D009765:Obesity / Q000188:drug therapy*; D010936:Plant Extracts / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D015431:Weight Loss
D019440:Anti-Obesity Agents; D010936:Plant Extracts; D064429:Fatty Acid Synthases