Congestive heart failure and diabetes mellitus: balancing glycemic control with heart failure improvement.
Diabetes mellitus (DM) and congestive heart failure (HF) commonly coexist in the same patient, and the presence of DM in HF patients is associated with increased adverse events compared with patients without DM. Recent guidelines regarding glycemic control stress individualization of glycemic therapy based on patient comorbid conditions and potential adverse effects of medical therapy. This balance in glycemic control may be particularly relevant in patients with DM and HF. In this review, we address data regarding the influence that certain HF medications may have on glycemic control. Despite potential modest changes in glycemic control, clinical benefits of proven pharmacologic HF therapies extend to patients with DM and HF. In addition, we review potential benefits and challenges associated with commonly used glycemic medications in HF patients. Finally, recent data and controversies on optimal glycemic targets in HF patients are discussed. Given the large number of patients with DM and HF and the health burden of these conditions, much needed future work is necessary to define the optimal glycemic treatment in HF patients with DM.
Winters Center for Heart Failure Research, and Section of Cardiology, Department of Medicine, Baylor College of Medicine, Houston, Texas 77030, USA. daguilar@bcm.edu
Saifullah
S
Nasir
David
D
Aguilar
D002317:Cardiovascular Agents / Q000627:therapeutic use*; D048909:Diabetes Complications / Q000188:drug therapy*; D006333:Heart Failure / Q000150:complications / Q000188:drug therapy*; D006801:Humans; D006943:Hyperglycemia / Q000209:etiology / Q000517:prevention & control*; D007004:Hypoglycemic Agents / Q000627:therapeutic use*; D016896:Treatment Outcome
D002317:Cardiovascular Agents; D007004:Hypoglycemic Agents