Copper(I)-catalyzed intramolecular O-arylation for the synthesis of 2,3,4,9-tetrahydro-1H-xanthen-1-ones with low loads of CuCl.
As little as 0.5 mol % CuCl is sufficient to catalyze the intramolecular O-arylation of easily accessible 2-(2-bromobenzyl)cyclohexane-1,3-diones to provide the corresponding 2,3,4,9-tetrahydro-1H-xanthen-1-ones with yields ranging from 83% to 99%.
Bioorganische Chemie, Institut für Chemie, Universität Hohenheim, Garbenstrasse 30, D-70599 Stuttgart, Germany.
Kavitha
K
Sudheendran
Chandi C
CC
Malakar
Jürgen
J
Conrad
Uwe
U
Beifuss
D002384:Catalysis; D003300:Copper / Q000737:chemistry; D003510:Cyclohexanes / Q000737:chemistry*; D015394:Molecular Structure; D044004:Xanthones / Q000138:chemical synthesis* / Q000737:chemistry*
D003510:Cyclohexanes; D044004:Xanthones; D003300:Copper; C009689:xanthone