Autism traits in individuals with agenesis of the corpus callosum.
Autism spectrum disorders (ASD) have numerous etiologies, including structural brain malformations such as agenesis of the corpus callosum (AgCC). We sought to directly measure the occurrence of autism traits in a cohort of individuals with AgCC and to investigate the neural underpinnings of this association. We screened a large AgCC cohort (n = 106) with the Autism Spectrum Quotient (AQ) and found that 45 % of children, 35 % of adolescents, and 18 % of adults exceeded the predetermined autism-screening cut-off. Interestingly, performance on the AQ's imagination domain was inversely correlated with magnetoencephalography measures of resting-state functional connectivity in the right superior temporal gyrus. Individuals with AgCC should be screened for ASD and disorders of the corpus callosum should be considered in autism diagnostic evaluations as well.
School of Medicine, University of California, San Francisco, 513 Parnassus Avenue, San Francisco, CA 94143, USA.
Yolanda C
YC
Lau
Leighton B N
LB
Hinkley
Polina
P
Bukshpun
Zoe A
ZA
Strominger
Mari L J
ML
Wakahiro
Simon
S
Baron-Cohen
Carrie
C
Allison
Bonnie
B
Auyeung
Rita J
RJ
Jeremy
Srikantan S
SS
Nagarajan
Elliott H
EH
Sherr
Elysa J
EJ
Marco
D000293:Adolescent; D000328:Adult; D061085:Agenesis of Corpus Callosum / Q000503:physiopathology / Q000523:psychology*; D002648:Child; D002659:Child Development Disorders, Pervasive / Q000175:diagnosis* / Q000503:physiopathology / Q000523:psychology; D002675:Child, Preschool; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D015225:Magnetoencephalography; D008297:Male; D011795:Surveys and Questionnaires