Low expression of FCGRIIB in macrophages of immune thrombocytopenia-affected individuals.
Immune thrombocytopenia (ITP) is an autoimmune disorder described as autoantibody-mediated platelet deterioration. Platelets with affiliated IgG are targeted for exploitation by Fc receptor-mediated phagocytic cellular material within the reticuloendothelial system. The objective of this research is to investigate the relationship between the appearance of FC gamma receptors (FCGR) IIB and IIIA on macrophages and clinicopathological characteristics in ITP patients. FCGRIIB and FCGRIIIA were recognized by immunohistochemistry staining of 62 samples, including regular (n = 20) and ITP (n = 42) samples. Subsequently, the relationship of FC gamma expression levels to ITP progression and clinicopathological characteristics was statistically reviewed. Furthermore, the relationship between Helicobacter pylori (HP) infection and FC gamma expression was analyzed. IHC staining with the coordinated spleen tissue trial samples showed that expression of FCGRIIB on macrophages of ITP patients was tremendously reduced in comparison to the healthy control group. However, no variance was discovered between the two groups with respect to FCGRIIIA expression. There was no substantial correlation among FCGRIIB and FCGRIIIA expression and patient age and gender. Significant differences were found between HP infection and decreased expression of FCGRIIB, while there was no difference with the expression of FCGRIIIA. Lower expression of FCGRIIB is likely involved in the etiology of ITP. HP infection is correlated with decreased expression of FCGRIIB. A rise in FCGRIIB may serve as a therapeutic target for human ITP treatment or possibly as a biomarker for ITP analysis.
Department of Hepatopancreatobiliary Surgery, West China Hospital, Sichuan University, Chengdu 610041, China.
Zhong
Z
Wu
Jin
J
Zhou
Pankaj
P
Prsoon
Xiaoxia
X
Wei
Xiaojing
X
Liu
Bing
B
Peng
D000293:Adolescent; D000328:Adult; D015415:Biomarkers / Q000378:metabolism; D001792:Blood Platelets / Q000378:metabolism* / Q000473:pathology; D002648:Child; D005260:Female; D005786:Gene Expression Regulation; D016481:Helicobacter Infections / Q000378:metabolism / Q000473:pathology; D016480:Helicobacter pylori; D006801:Humans; D008297:Male; D008875:Middle Aged; D016553:Purpura, Thrombocytopenic, Idiopathic / Q000378:metabolism* / Q000473:pathology; D017452:Receptors, IgG / Q000096:biosynthesis*; D013154:Spleen / Q000378:metabolism / Q000473:pathology
D015415:Biomarkers; C080568:Fc gamma receptor IIA; C080571:Fc gamma receptor IIB; D017452:Receptors, IgG