[Effect of bisphenol A exposure during early development on body weight and glucose metabolism of female filial rats].
OBJECTIVE
To investigate the effect of bisphenol A (BPA) exposure during early development on body weight and glucose metabolism of female filial rats.


METHODS
Pregnant Sprague-Dawley rats were exposed by drinking water containing 1 microg/ml BPA from the 6th day of gestation to the end of lactation. Body weight of female pups was measured on born, during lactation and after weaning. The levels of fasting blood glucose, insulin and leptin, the weight of liver and kidney and peri-gonadal and peri-renal adipose tissue were measured, and the organ and adipose tissue coefficients were calculated.


RESULTS
Compared with the control pubs, the body weight of pups in BPA-exposed group was significantly higher at born and after weaning, the virginal and gonadal adipose tissue coefficient was significantly higher, and the levels of fasting blood glucose, serum insulin were increased but leptin decreased.


CONCLUSIONS
BPA exposure during early development could increase the body weight and result in insulin resistance. The decrease of serum leptin resulted from BPA exposure maybe one of reasons related to obesity and insulin resistance.
Department of Child and Adolescent Health, School of Public Health, China Medical University, Shenyang 110001, China. lllucy_hi@126.com
Lu
L
Liu
Cuicui
C
Ma
Zhaofeng
Z
Wen
Ling
L
Zhang
Zhiyu
Z
Zhang
Lihong
L
Jia
D000273:Adipose Tissue; D000818:Animals; D001559:Benzhydryl Compounds / Q000633:toxicity*; D001835:Body Weight / Q000187:drug effects; D001942:Breast Feeding; D005260:Female; D005947:Glucose; D007328:Insulin; D007333:Insulin Resistance; D007774:Lactation; D020738:Leptin; D009765:Obesity / Q000139:chemically induced*; D010636:Phenols / Q000633:toxicity*; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D051381:Rats; D017207:Rats, Sprague-Dawley; D014886:Weaning; D000098826:Bisphenol A Compounds
D001559:Benzhydryl Compounds; D005947:Glucose; D007328:Insulin; D020738:Leptin; D010636:Phenols; C006780:bisphenol A; D000098826:Bisphenol A Compounds