Two novel ansamitocin analogs from Actinosynnema pretiosum.
By using various column chromatography for purification, two new compounds of ansamitocin (1 and 2) were isolated from the extracts of fermentation broth of Actinosynnema pretiosum FIM06-0063. Their structures were established as maytansinol-9-methyl ether-3-propionate (1) and maytansinol-9-methyl ether-3-3'-methy-butyrate (2), respectively, by an extensive NMR analysis.
College of Pharmacy, Fujian Medical University, Fuzhou, China.
Siyu-Mao
Hong-Chen
Li-Chen
Chuanxi-Wang
Wei-Jia
Xiaoming-Chen
Huangjian-Yang
Wei-Huang
Wei-Zheng
D000192:Actinomycetales / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D008453:Maytansine / Q000031:analogs & derivatives* / Q000737:chemistry
D008453:Maytansine; C015682:ansamitocins