Evaluation and histological maturation characteristics of fibrous dysplasia and ossifying fibroma: a case series.
BACKGROUND
Fibrous dysplasia (FD) and ossifying fibroma (OF) are benign fibro-osseous lesions (FOLS) that are generally considered to be separate entities distinguishable by histologic and radiographic features. The histological maturation of these lesions involves an initial fibrous state, an intermediate mixed and a final mineralised stage.


OBJECTIVE
To correlate the mineralisation of OF and FD with the duration of the lesion.


METHODS
A retrospective histopathological analysis of archival material including sixteen cases documented over a three-year period was performed to distinguish FD from OF.


METHODS
The relevant data of FOLs diagnosed as OF and FD were retrieved from the archival records of the Departments of Oral Surgery/Oral Pathology and Histopathology/Morbid Anatomy, Muhimbili University of Health and Allied Sciences.


RESULTS
Remarkably, in this series, none of the FD and OF lesions occurred in patients aged below 10 or over 50 years. The histopathological comparison of the various non-mineralised components in both the lesions in relation to lesion age-maturity was not statistically significant (P>0.05).


CONCLUSIONS
The histopathological ratio of the mineralised to non-mineralised components may not be directly indicative of the maturity of both OF and FD.
Department of Oral Surgery and Oral Pathology, Muhimbili University of Health and Allied Sciencies, P.O. Box 65014, Dar es Salaam, Tanzania.
J L
JL
Moshy
H A
HA
Mwakyoma
M L
ML
Chindia
D000293:Adolescent; D000328:Adult; D000367:Age Factors; D001859:Bone Neoplasms / Q000473:pathology*; D002648:Child; D005260:Female; D018214:Fibroma, Ossifying / Q000473:pathology*; D005357:Fibrous Dysplasia of Bone / Q000473:pathology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D055815:Young Adult