Some heterocyclic thione derivatives exhibit anticoccidial activity by inhibiting glycosidases.
Coccidiosis is one of the most common parasitic diseases affecting many species of domestic animals. This disease has a major economic significance and the search for new compounds having anticoccidial activity is of great importance. In this article, different levels of protection from coccidian infection by Eimeria stiedae were developed in rabbits by treatment with compounds incorporating the skeleton of thiourea. These compounds include 4,5-diphenylimidazole-2-thione (1), 4,5-Diphenyl-1,2,4-triazole-3-thiol (2) and 5-(2-Hydroxyphenyl)-4-phenyl-1,2,4-triazole-3-thiol (3) compared to the anticoccidial drug toltrazuril as a reference compound. Compounds 1-3 inhibit coccidiosis-induced activity of α-glucosidase. The protection from coccidial infection by compound 1 was higher than that shown for compounds 2 and 3. These data suggest that diazole and triazole thione derivatives have a mimetic effect for anticoccidial drugs through their inhibition of glycosidases.
Biochemistry Department, Faculty of Science, Alexandria University, Alexandria, Egypt.
Mahmoud
M
Balbaa
Neama
N
Abd El-Hady
Nabil
N
Taha
El Sayed H
el SH
El Ashry
D000818:Animals; D003048:Coccidiosis / Q000188:drug therapy / Q000382:microbiology / Q000469:parasitology / Q000662:veterinary; D003049:Coccidiostats / Q000494:pharmacology; D004539:Eimeria / Q000187:drug effects / Q000201:enzymology / Q000472:pathogenicity; D004791:Enzyme Inhibitors / Q000494:pharmacology; D006026:Glycoside Hydrolases / Q000037:antagonists & inhibitors / Q000097:blood*; D011817:Rabbits; D013871:Thiones / Q000138:chemical synthesis / Q000494:pharmacology*
D003049:Coccidiostats; D004791:Enzyme Inhibitors; D013871:Thiones; D006026:Glycoside Hydrolases