A meta-analysis of the association between angiotensin-converting enzyme insertion/deletion gene polymorphism and end-stage renal disease risk in IgA nephropathy patients.
OBJECTIVE
The association between angiotensin-converting enzyme (ACE) insertion/deletion (I/D) gene polymorphism and end-stage renal disease (ESRD) risk in IgA nephropathy (IgAN) patients is still controversial. A meta-analysis was performed to evaluate the association between ACE I/D gene polymorphism and ESRD susceptibility in IgAN patients.


METHODS
A predefined literature search and selection of eligible relevant studies were performed to collect data from electronic databases.


RESULTS
Thirteen articles were identified for the analysis of the association between ACE I/D gene polymorphism and ESRD risk in IgAN patients. D allele and DD genotype were associated with ESRD susceptibility in IgAN patients for overall populations (p=0.01 and 0.003, respectively). In Asians, there was a markedly positive association between DD genotype and ESRD susceptibility (p=0.03). Furthermore, D allele and DD genotype were associated with ESRD susceptibility in Caucasians (p=0.02 and 0.03, respectively). However, II genotype might not play a protective role against ESRD onset for overall populations, Asians and Caucasians.


CONCLUSIONS
DD homozygote is a significant genetic molecular marker for the onset of ESRD in IgAN patients.
Department of Pediatric Nephrology, The First Affiliated Hospital of Guangxi Medical University, China. a126tianbiao@126.com
Tian-Biao
TB
Zhou
Sheng-Sheng
SS
Yin
Rong
R
Liang
D000483:Alleles; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D005922:Glomerulonephritis, IGA / Q000150:complications / Q000201:enzymology / Q000235:genetics*; D006801:Humans; D054643:INDEL Mutation / Q000235:genetics*; D007676:Kidney Failure, Chronic / Q000150:complications / Q000201:enzymology / Q000235:genetics*; D007703:Peptidyl-Dipeptidase A / Q000235:genetics*; D011110:Polymorphism, Genetic; D017594:Publication Bias; D012307:Risk Factors
C488034:ACE protein, human; D007703:Peptidyl-Dipeptidase A