Nutrition in pancreatitis.
Severe acute pancreatitis causes an initial systemic inflammatory response syndrome (SIRS) that drives the morbidity and mortality associated with this disease process. Failure to utilize the gastrointestinal tract leads to loss of gut integrity and a gut-lung axis of inflammation that generates a secondary SIRS response, further worsening patient outcome. Optimal nutrition therapy involves determination of disease severity, confirming adequate volume resuscitation, achieving enteral access, and initiating feeds with an immune-modulating formula as soon as possible after admission to the intensive care unit. Provision of early enteral nutrition is therapeutic, changing the patient's hospital course in a favorable manner.
Department of Medicine, University of Louisville School of Medicine, Louisville, Ky., USA.
Stephen A
SA
McClave
D000208:Acute Disease; D004032:Diet; D004750:Enteral Nutrition / Q000379:methods*; D006801:Humans; D009751:Nutritional Requirements; D009752:Nutritional Status; D010195:Pancreatitis / Q000150:complications / Q000503:physiopathology / Q000628:therapy*; D010288:Parenteral Nutrition / Q000379:methods; D016032:Randomized Controlled Trials as Topic; D018746:Systemic Inflammatory Response Syndrome / Q000209:etiology / Q000628:therapy; D016896:Treatment Outcome