Investigating the parameters affecting the stability of superparamagnetic iron oxide-loaded nanoemulsion using artificial neural networks.
Nanoemulsions are increasingly being investigated for their fascinating capability of loading both hydrophobic and hydrophilic molecules while their stability is still an issue, being affected by various factors. In this study, to evaluate the dominant factors affecting the stability of nanoemulsions, artificial neural networks (ANNs) were implemented. Nanoemulsions of almond oil in water containing oleic acid-coated superparamagnetic iron oxide nanoparticles were prepared using a mixture of Tween 80 and Span 80 as surfactant system and ethanol as a co-surfactant. The ratio of transparency of the samples at 30 min and 7 days after preparation was taken as an indication of the stability of samples. Four independent variables, namely, concentration of nanoparticle, surfactant, oil, and alcohol were investigated to find their relations with the dependent variable (i.e., transparency ratio). Using ANNs modeling, it was concluded that the stability is affected by all variables, with all variables showing reverse effect on the stability beyond an optimum amount.
Department of Medical Nanotechnology, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran.
Gholamreza
G
Ahmadi Lakalayeh
Reza
R
Faridi-Majidi
Reza
R
Saber
Alireza
A
Partoazar
Shahram Ejtemaei
SE
Mehr
Amir
A
Amani
D004355:Drug Stability; D004655:Emulsions / Q000737:chemistry*; D000431:Ethanol / Q000737:chemistry; D005290:Ferric Compounds / Q000737:chemistry*; D006601:Hexoses / Q000737:chemistry; D057927:Hydrophobic and Hydrophilic Interactions; D053758:Nanoparticles / Q000737:chemistry*; D016571:Neural Networks, Computer; D019301:Oleic Acid / Q000737:chemistry; D010316:Particle Size; D010938:Plant Oils / Q000737:chemistry; D011136:Polysorbates / Q000737:chemistry; D013501:Surface-Active Agents / Q000737:chemistry; D014867:Water / Q000737:chemistry
D004655:Emulsions; D005290:Ferric Compounds; D006601:Hexoses; D010938:Plant Oils; D011136:Polysorbates; D013501:Surface-Active Agents; D014867:Water; C018665:sorbitan monooleate; C000499:ferric oxide; D019301:Oleic Acid; D000431:Ethanol; C068582:almond oil