Evaluation of Oral Glucose Tolerance Test in Children With Epilepsy.
Glucose metabolism of children with drug-resistant epilepsy, controlled by antiepileptic drugs epilepsy, and first-time nonfebrile seizures was studied through the performance of an oral glucose tolerance test and through insulin, C-peptide, and glycosylated hemoglobin measurements. In the refractory epilepsy group, there were more abnormal oral glucose tolerance test results (62.07%) in comparison to the controlled epilepsy group (25%) and the group of first-time seizures (21.21%). There was a significant difference between the group of refractory epilepsy and every other group concerning the abnormality of the oral glucose tolerance test (P < .05). The mean values of insulin, HbA1c, and C-peptide levels were normal for all groups. The results of the present study suggest that there is a distinction of refractory epilepsies from the drug-controlled ones and the first-induced seizures relating to their metabolic profile, regardless of the type of seizures.
1Department of Pediatrics, School of Medicine, Aristotle University of Thessaloniki, Papageorgiou General Hospital, Thessaloniki, Greece.
Sotirios
S
Varlamis
Norma
N
Vavatsi
Evangelos
E
Pavlou
Vasileios
V
Kotsis
Martha
M
Spilioti
Maria
M
Kavga
George
G
Varlamis
Foteini
F
Sotiriadou
Eleni
E
Agakidou
Spyridon
S
Voutoufianakis
Athanasios E
AE
Evangeliou