[Probiotics for the prevention of antibiotic-induced diarrhea].
Between 5 and 49% of patients treated with antibiotics suffer from diarrhoea. Principally all microbial agents can cause diarrhoea, especially oral agents like cephalosporines, clindamycin, broad-spectrum penicillins, and quinolones of the 3  rd and 4th generation. Manifestations of antibiotic-associated diarrhoea range from mild self-limiting forms to severe life-threatening courses. The potentially most severe form of antibiotic-associated diarrhoea is caused by Clostridium diffcile accounting for approx. 25  % of antibiotic-associated diarrhoea. In the past two decades a broad spectrum of different probiotic strains has been evaluated for the primary prevention of antibiotic-associated diarrhoea in children and adults. Based on their efficacy and clinical data, different levels of evidence and recommendations are emerging on the preventive use of probiotics in antibiotic-associated diarrhoea.
Universitätsklinik für Innere Medizin III, Medizinische Universität Wien, Österreich.
A
A
Eser
F
F
Thalhammer
F
F
Burghuber
C
C
Högenauer
F
F
Stockenhuber
C
C
Wenisch
K
K
Widhalm
W
W
Reinisch
D000328:Adult; D000900:Anti-Bacterial Agents / Q000009:adverse effects*; D002648:Child; D003967:Diarrhea / Q000188:drug therapy / Q000209:etiology* / Q000517:prevention & control*; D006801:Humans; D019936:Probiotics / Q000627:therapeutic use*; D016896:Treatment Outcome
D000900:Anti-Bacterial Agents