Arabin cervical pessary to prevent preterm birth in severe twin-to-twin transfusion syndrome treated by laser surgery.
OBJECTIVE
To describe the outcome of patients with twin-to-twin transfusion syndrome and cervical length ≤ 25 mm, treated with laser and an Arabin cervical pessary.


METHODS
Retrospective analysis of a consecutive series of all cases with severe twin-to-twin transfusion syndrome who underwent laser surgery: a group with cervical length above 25 mm (group A) and two groups who had a cervical length of 25 mm or less prior to the procedure. The first 8 cases (group B) were managed expectantly and the next 8 cases had a cervical pessary inserted immediately after laser surgery (group C). Gestational age at birth was the primary outcome. The secondary outcome was a composite one encompassing severe neonatal morbidity.


RESULTS
The median gestational age at laser surgery was 20 weeks in all groups but the median gestational age at delivery was significantly higher in group C versus B (28 vs 32 weeks, p = 0.01). Severe neonatal morbidity was present in 18% in group C and 70% in group B (p < 0.01).


CONCLUSIONS
Early results suggest a potential role for pessary use in prolonging gestation in cases with shortened cervix at the time of laser. A randomized trial to test this hypothesis should be performed.
Maternal-Fetal Medicine Unit, Department of Obstetrics, Hospital Universitari Vall d'Hebron, Universitat Autònoma de Barcelona, Barcelona, Catalonia, Spain. ecarreras@vhebron.net
Elena
E
Carreras
Silvia
S
Arévalo
Juan Carlos
JC
Bello-Muñoz
Maria
M
Goya
Carlota
C
Rodó
Maria Angeles
MA
Sanchez-Duran
Jose Luis
JL
Peiro
Lluís
L
Cabero
D000328:Adult; D002584:Cervix Uteri / Q000601:surgery; D005260:Female; D005330:Fetofetal Transfusion / Q000453:epidemiology / Q000601:surgery*; D005332:Fetoscopy / Q000009:adverse effects / Q000379:methods / Q000706:statistics & numerical data; D006801:Humans; D007231:Infant, Newborn; D053685:Laser Therapy / Q000009:adverse effects / Q000379:methods* / Q000706:statistics & numerical data; D010570:Pessaries / Q000706:statistics & numerical data; D011247:Pregnancy; D011256:Pregnancy Outcome / Q000453:epidemiology; D047928:Premature Birth / Q000453:epidemiology / Q000209:etiology / Q000517:prevention & control* / Q000601:surgery; D012189:Retrospective Studies; D012720:Severity of Illness Index