Modular synthesis of phenanthridine derivatives by oxidative cyclization of 2-isocyanobiphenyls with organoboron reagents.
Where HAS you been? A manganese-mediated annulation of 2-isocyanobiaryls with organoboronic acids is developed for the synthesis of a broad range of phenanthridine derivatives. Mechanistic studies indicate that the reaction proceeds by the intramolecular homolytic aromatic substitution (HAS) of an imidoyl radical intermediate.
Center for Atomic and Molecular Technologies, Graduate School of Engineering, Osaka University, Suita, Japan. tobisu@chem.eng.osaka-u.ac.jp
Mamoru
M
Tobisu
Keika
K
Koh
Takayuki
T
Furukawa
Naoto
N
Chatani