Effects of degradable MG-ND-ZN-ZR alloy on osteoblastic cell function.
This study aimed to investigate the effects of a novel patented Mg-3Nd-0.2Zn-0.4Zr (weight %, JDBM) alloy on osteoblastic cell function, as these cells play an important role in bone repair and remodeling. The associated effects of the JDBM alloy on osteoblastic cell function involving cell adhesion, cell proliferation, and mineralization were investigated using scanning electron microscopy (SEM), MTT assay and ambramycin staining, respectively. At the same time, the in vitro degradation behavior of the JDBM alloy in cell culture medium was evaluated by the weight-loss method and SEM. Pure magnesium was used as control. The results showed that osteoblastic cells cultured on JDBM alloy samples manifested better cell adhesion, improved cell proliferation and increased mineralization ability, compared with cells seeded on pure magnesium samples. Our data indicate that the JDBM alloy has excellent bioactivity, improving the cell function of osteoblastic cells seeded on it.
Department of Orthopaedics, Sixth People's Hospital of Shanghai JiaoTong University, Shanghai, China.
Y
Y
Wang
Y
Y
Ouyang
X
X
Pang
L
L
Mao
G
G
Yuan
Y
Y
Jiang
Y
Y
He
D016475:3T3 Cells; D000497:Alloys / Q000737:chemistry / Q000494:pharmacology*; D000818:Animals; D001672:Biocompatible Materials; D002113:Calcification, Physiologic / Q000187:drug effects; D002448:Cell Adhesion / Q000187:drug effects; D049109:Cell Proliferation / Q000187:drug effects; D003343:Corrosion; D008274:Magnesium / Q000494:pharmacology; D051379:Mice; D008855:Microscopy, Electron, Scanning; D010006:Osteoblasts / Q000187:drug effects* / Q000378:metabolism / Q000648:ultrastructure; D013997:Time Factors
D000497:Alloys; D001672:Biocompatible Materials; C571250:Mg-Nd-Zn-Zr alloy; D008274:Magnesium