CD133 in the selection of epidermal stem cells in mice: steps in the right direction.
Charruyer and colleagues (this issue) report two significant advances to the field of cutaneous keratinocyte stem cells: a pair of new selectable markers that recognize a subset of α6(+)CD34(+) label-retaining cells, and an in vivo limiting dilution assay for keratinocyte stem cells with long-term repopulating ability. This work has important implications for keratinocyte stem cell identification and assay, as well as for the identification of target cells in non-melanoma skin cancer.
Department of Dermatology, College of Physicians and Surgeons, Columbia University, New York, New York, USA.
Anna S
AS
Nordvig
David M
DM
Owens
Rebecca J
RJ
Morris
D000071916:AC133 Antigen; D000818:Animals; D015703:Antigens, CD / Q000378:metabolism*; D000078404:Epidermal Cells; D004817:Epidermis / Q000502:physiology*; D006023:Glycoproteins / Q000378:metabolism*; D015603:Keratinocytes / Q000166:cytology*; D051379:Mice; D039902:Multipotent Stem Cells / Q000166:cytology*; D010455:Peptides / Q000378:metabolism*
D000071916:AC133 Antigen; D015703:Antigens, CD; D006023:Glycoproteins; D010455:Peptides; C000606024:Prom1 protein, mouse