Cellular senescence in cardiovascular diseases: potential age-related mechanisms and implications for treatment.
The aging process is associated with a loss of complexity in the dynamics of physiological systems that reduce the ability to adapt to stress, causing frailty and/or age-related diseases. At the cellular level, proliferative and/or oxidative-stress induced cell senescence associated with a pro-inflammatory state may greatly contribute to age-associated impaired tissue and organ functions. Senescence of endothelial and cardiac cells observed over normal aging, appear to be accelerated in age-related diseases and in particular, in cardiovascular disease (CVD). Although the molecular mechanisms of cellular senescence have been extensively studied, a complete understanding of their role in CVD is still limited. Cardiac, endothelial (EC), vascular smooth muscle (VSMC), leukocytic and stem cells (endothelial progenitor cells (EPC), embryonic stem cells (ESC) and haematopoietic stem cells (HSC)) may play a pivotal role on the maintenance and regeneration of cardiovascular tissue. Age-associated changes of such cells may enhance the risk of developing CVD. The purpose of this review is to illustrate how cellular senescence may affect tissue repair and maintenance toward CVD, focusing on the role played by telomere length and microRNA expression. Finally, interventions aimed at improving the age-related decline in vascular cells during aging and disease, as well as strategies to harness the regenerative capacity of stem cells in CVD will be discussed.
Dept. of Clinical and Molecular Sciences (DISCLIMO), Universita Politecnica delle Marche, Via Tronto 10/A - 60020 Ancona (Italy). f.olivieri@univpm.it
Fabiola
F
Olivieri
Rina
R
Recchioni
Fiorella
F
Marcheselli
Angela Marie
AM
Abbatecola
Gabriele
G
Santini
Giulia
G
Borghetti
Roberto
R
Antonicelli
Antonio Domenico
AD
Procopio
D000375:Aging; D002318:Cardiovascular Diseases / Q000473:pathology*; D016922:Cellular Senescence; D004730:Endothelium, Vascular / Q000473:pathology*; D006801:Humans; D035683:MicroRNAs / Q000378:metabolism; D013234:Stem Cells / Q000378:metabolism; D016615:Telomere
D035683:MicroRNAs