Chelator-based catheter lock solutions in eradicating organisms in biofilm.
Two different chelator-based antimicrobial catheter lock solutions, methylene blue-citrate-parabens (MB-CIT) and minocycline-EDTA-25% ethanol (M-EDTA-25% ETOH), were compared in 2-h biofilm eradication experiments. Eradication of both mature and immature Gram-positive, Gram-negative, and fungal biofilms was assessed. M-EDTA-25% ETOH was able to fully eradicate all biofilms within 2 h. MB-CIT was only effective against immature biofilms but was unable to fully eradicate most of the mature biofilms tested.
Department of Infectious Diseases, Infection Control and Employee Health, The University of Texas M. D. Anderson Cancer Center, Houston, Texas, USA. iraad@mdanderson.org
I
I
Raad
J
J
Rosenblatt
R
R
Reitzel
Y
Y
Jiang
T
T
Dvorak
R
R
Hachem
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D018441:Biofilms / Q000187:drug effects* / Q000254:growth & development; D057785:Catheters / Q000382:microbiology; D002614:Chelating Agents / Q000494:pharmacology*; D002951:Citrates; D004202:Disinfectants / Q000494:pharmacology*; D004492:Edetic Acid; D000431:Ethanol; D005658:Fungi / Q000187:drug effects* / Q000254:growth & development; D006090:Gram-Negative Bacteria / Q000187:drug effects* / Q000254:growth & development; D006094:Gram-Positive Bacteria / Q000187:drug effects* / Q000254:growth & development; D008751:Methylene Blue; D008911:Minocycline; D010226:Parabens; D012996:Solutions
D000900:Anti-Bacterial Agents; D002614:Chelating Agents; D002951:Citrates; D004202:Disinfectants; D010226:Parabens; D012996:Solutions; D000431:Ethanol; D004492:Edetic Acid; D008911:Minocycline; D008751:Methylene Blue