Dietary fibers solubilized in water or an oil emulsion induce satiation through CCK-mediated vagal signaling in mice.
This study focused on the fate of the satiating potency of dietary fibers when solubilized in a fat-containing medium. Fourteen percent of either guar gum (GG) or fructo-oligosaccharide (FOS) or a mixture of the 2 (GG-FOS, 5% GG and 9% FOS) were solubilized in water or an oil emulsion (18-21% rapeseed oil in water, v:v) and administered by gavage to mice before their food intake was monitored. When compared with water (control), only GG-FOS solubilized in water or in the oil emulsion reduced daily energy intake by 21.1 and 14.1%, respectively. To further describe this effect, the meal pattern was characterized and showed that GG-FOS increased satiation without affecting satiety by diminishing the size and duration of meals for up to 9 h after administration independently of the solubilization medium. The peripheral blockade of gut peptide receptors showed that these effects were dependent on the peripheral signaling of cholecystokinin but not of glucagon-like peptide 1, suggesting that anorectic signals emerge from the upper intestine rather than from distal segments. Measurements of neuronal activation in the nucleus of solitary tract supported the hypothesis of vagal satiation signaling because a 3-fold increase in c-Fos protein expression was observed in that nucleus after the administration of GG-FOS, independently of the solubilization medium. Taken together, these data suggest that a mixture of GG and FOS can maintain its appetite suppressant effect in fatty media. Adding these dietary fibers to fat-containing foods might therefore be useful in managing food intake.
AgroParisTech, France.
Rojo
R
Rasoamanana
Catherine
C
Chaumontet
Nachiket
N
Nadkarni
Daniel
D
Tomé
Gilles
G
Fromentin
Nicolas
N
Darcel
D000818:Animals; D002766:Cholecystokinin / Q000378:metabolism*; D004043:Dietary Fiber / Q000032:analysis / Q000494:pharmacology; D004435:Eating / Q000187:drug effects; D005685:Galactans / Q000737:chemistry / Q000494:pharmacology*; D008297:Male; D008351:Mannans / Q000737:chemistry / Q000494:pharmacology*; D051379:Mice; D008810:Mice, Inbred C57BL; D009821:Oils; D009844:Oligosaccharides / Q000737:chemistry / Q000494:pharmacology*; D053149:Plant Gums / Q000737:chemistry / Q000494:pharmacology*; D012528:Satiety Response / Q000187:drug effects*; D015398:Signal Transduction / Q000187:drug effects*; D014630:Vagus Nerve / Q000187:drug effects / Q000502:physiology*; D014867:Water
D004043:Dietary Fiber; D005685:Galactans; D008351:Mannans; D009821:Oils; D009844:Oligosaccharides; D053149:Plant Gums; C116580:fructooligosaccharide; D014867:Water; D002766:Cholecystokinin; C007894:guar gum