Discovery of amide based fibrates as possible antidyslipidemic and antioxidant agents.
A novel series of amide based fibrates were synthesized and evaluated for antidyslipidemic activity in triton induced hyperlipidemic rats. Interestingly, the compound 13 produced striking reduction in serum levels of total cholesterol (TC), phospholipids (PL) and triglycerides (TG). In addition, it exhibited improved lipoprotein lipase activity and found to possess moderate radical scavenging potential. The results of the above studies shows that the compounds synthesized on fibrate based pharmacophores might result in identification of new lead for dyslipidemia.
Medicinal and Process Chemistry Division, CSIR-Central Drug Research Institute, Chattar Manzil Palace, Lucknow 226 001, Uttar Pradesh, India. kv_sashidhara@cdri.res.in
Koneni V
KV
Sashidhara
Gopala Reddy
GR
Palnati
Ranga Prasad
RP
Dodda
Ravi
R
Sonkar
A K
AK
Khanna
Gitika
G
Bhatia
D000577:Amides / Q000138:chemical synthesis* / Q000494:pharmacology; D000818:Animals; D000975:Antioxidants / Q000138:chemical synthesis* / Q000494:pharmacology; D004789:Enzyme Activation / Q000187:drug effects; D058607:Fibric Acids / Q000138:chemical synthesis* / Q000494:pharmacology; D005609:Free Radicals / Q000037:antagonists & inhibitors; D006949:Hyperlipidemias / Q000097:blood / Q000139:chemically induced / Q000188:drug therapy* / Q000201:enzymology; D000960:Hypolipidemic Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D015227:Lipid Peroxidation / Q000187:drug effects; D008071:Lipoprotein Lipase / Q000097:blood*; D008297:Male; D011092:Polyethylene Glycols; D051381:Rats; D013329:Structure-Activity Relationship
D000577:Amides; D000975:Antioxidants; D058607:Fibric Acids; D005609:Free Radicals; D000960:Hypolipidemic Agents; D011092:Polyethylene Glycols; D008071:Lipoprotein Lipase; C016811:tyloxapol