Pathophysiology of new bone formation and ankylosis in spondyloarthritis.
The outcome of patients suffering from spondyloarthritis is determined by chronic inflammation and new bone formation leading to ankylosis. The latter process manifests by new cartilage and bone formation leading to joint or spine fusion. This article discusses the main mechanisms of new bone formation in spondyloarthritis. It reviews the key molecules and concepts of new bone formation and ankylosis in animal models of disease and translates these findings to human disease. In addition, proposed biomarkers of new bone formation are evaluated and the translational current and future challenges are discussed with regards to new bone formation in spondyloarthritis.
Laboratory for Skeletal Development and Joint Disorders, Department of Development and Regeneration, Leuven, Belgium. Rik.Lories@uz.kuleuven.be
Rik J U
RJ
Lories
Georg
G
Schett
D000844:Ankylosis / Q000378:metabolism / Q000473:pathology* / Q000503:physiopathology*; D015415:Biomarkers / Q000378:metabolism; D002908:Chronic Disease; D006801:Humans; D007249:Inflammation / Q000378:metabolism; D010012:Osteogenesis / Q000502:physiology*; D013131:Spine / Q000473:pathology*; D025241:Spondylarthritis / Q000378:metabolism / Q000473:pathology* / Q000503:physiopathology*; D013167:Spondylitis, Ankylosing / Q000378:metabolism / Q000473:pathology / Q000503:physiopathology
D015415:Biomarkers