Haemophagocytic syndrome associated with mucormycosis infection.
Several clinical forms of mucormycosis are recognized. The tendency of mucoraceous zygomycetes to invade the blood vessels often produces a disseminated infection. A case of disseminate mucormycosis complicated by a haemophagocytic syndrome (HS) in a 32-year-old Caucasian male is reported in this article. Few cases of infection-associated HS (IAHS), involving infections caused by fungi, have been reported. In all the recorded cases, the fungal infection coexists with malignant lymphoma, immunodeficiency and a long-term steroid therapy for renal transplant or Crohn's disease. This is the second described case of the HS due to mucormycosis.
Pathologic Anatomy Unit, Catholic University, Rome, Italy. vincenzo.arena@rm.unicatt.it
V
V
Arena
F
F
De-Giorgio
I
I
Pennacchia
R
R
Manna
G
G
Vetrugno
E
E
Stigliano
N
N
Milic
G
G
Gasbarrini
L
L
Abenavoli
D000328:Adult; D001344:Autopsy; D001706:Biopsy; D001856:Bone Marrow Examination; D017809:Fatal Outcome; D005753:Gastric Mucosa / Q000473:pathology; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D008099:Liver / Q000473:pathology; D051359:Lymphohistiocytosis, Hemophagocytic / Q000175:diagnosis / Q000188:drug therapy / Q000382:microbiology*; D008297:Male; D009091:Mucormycosis / Q000150:complications / Q000175:diagnosis / Q000188:drug therapy / Q000382:microbiology*; D011237:Predictive Value of Tests; D016896:Treatment Outcome
D007166:Immunosuppressive Agents