Blood alterations preceding clinical manifestation of glioblastoma.
BACKGROUND
There is little knowledge on blood alterations of glioblastoma. We had the opportunity to investigate markers from plasma taken 66, 36, and 6 months before glioblastoma in a patient in the VITA study.


METHODS
We determined S100B, secretagogin, neuropeptide-Y, micro-RNA-21, let-7, micro-RNA-128, and micro-RNA-342-3p in our patient and 10 controls from VITA.


RESULTS
We found a four-fold increase of micro-RNA-21 in the plasma of glioblastoma patient, whereas controls showed a significant decrease. There was no difference in other protein or micro-RNA levels between the patient and controls.


CONCLUSIONS
Plasma micro-RNA-21 may be associated with glioblastoma development in individual cases.
Department of Oncology, Medical University of Vienna, Vienna, Austria.
Aysegül
A
Ilhan-Mutlu
Ludwig
L
Wagner
Adelheid
A
Wöhrer
Susanne
S
Jungwirth
Christine
C
Marosi
Peter
P
Fischer
Matthias
M
Preusser
D000368:Aged; D015415:Biomarkers / Q000097:blood*; D001932:Brain Neoplasms / Q000097:blood*; D005260:Female; D005909:Glioblastoma / Q000097:blood*; D006801:Humans; D008297:Male; D035683:MicroRNAs / Q000096:biosynthesis / Q000097:blood*
D015415:Biomarkers; C524940:MIRN21 microRNA, human; D035683:MicroRNAs