IgG, IgM and inflammatory markers serum concentration in patients with acute coronary syndrome: a pilot study.
BACKGROUND
A number of biomarkers have been found that might help to predict the risk of acute coronary syndrome (ACS) in adults.


OBJECTIVE
To analyse the association between immunoglobulins concentration and other inflammatory markers such as C-reactive protein (CRP) and fibrinogen that show correlation with the risk of ACS.


METHODS
The study population consists of 52 consecutive patients with ST segment elevation myocardial infarction (STEMI) or unstable angina/non-STEMI. Concentrations of total protein, albumin, alpha-1 globulin, beta globulin, gamma protein, immunoglobulin in class A (IgA), G (IgG), M (IgM) and E (IgE), creatinine kinase (CK), creatinine kinase MB (CK-MB), CRP and fibrinogen were quantified.


RESULTS
In the ACS patients, there was a significant increase in gamma globulin, CRP and fibrinogen. IgG was elevated only in the STEMI group and correlated with fibrinogen (R = 0.48, p 〈 0.01).


CONCLUSIONS
1. IgG appears to be the only immunoglobulin associated with ACS in the STEMI group. 2. Fibrinogen reveals features of a reactive biomarker of ACS. 3. CRP appears to be closely related to the causative process in coronary artery disease patients.
1st Department of Cardiology, Medical University of Warsaw, 02–097 Warsaw, Poland. lukasz@koltowski.com
Lukasz
L
Kołtowski
Krzysztof J
KJ
Filipiak
Adam
A
Rdzanek
Violetta
V
Stępień
Bożenna
B
Tarchalska-Kryńska
Grzegorz
G
Opolski
D054058:Acute Coronary Syndrome / Q000097:blood* / Q000209:etiology; D000789:Angina, Unstable / Q000097:blood / Q000150:complications; D015415:Biomarkers / Q000097:blood; D002097:C-Reactive Protein / Q000378:metabolism; D005260:Female; D005340:Fibrinogen / Q000378:metabolism; D005500:Follow-Up Studies; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood*; D007075:Immunoglobulin M / Q000097:blood*; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000097:blood / Q000150:complications; D010865:Pilot Projects
D015415:Biomarkers; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D005340:Fibrinogen; D002097:C-Reactive Protein