Role of defective thymic function in onset of ganciclovir-resistant cytomegalovirus after cord blood transplantation.
A case of recurrent cytomegalovirus reactivations in a cytomegalovirus-seropositive woman who received allogeneic cord blood transplantation is described. Thirteen months posttransplantation, her CD3(+) T cell count was extremely low whereas natural killer cells represented 66% of her total lymphocytes. She showed defective thymic function that might contribute to the onset of valganciclovir resistance.
Instituto Maimónides de Investigación Biomédica de Córdoba-Reina Sofia University Hospital-University of Cordoba, Cordoba, Spain. sacanti@hotmail.com
Sara
S
Cantisán
Carmen
C
Martín
María C
MC
Romero-Sánchez
Sara
S
Ferrando-Martínez
Francisco
F
Martínez
Antonio
A
Rivero
Antonio
A
Torres
Rafael
R
Solana
Julián
J
Torre-Cisneros
D000328:Adult; D000998:Antiviral Agents / Q000494:pharmacology*; D036101:Cord Blood Stem Cell Transplantation / Q000009:adverse effects*; D003586:Cytomegalovirus Infections / Q000276:immunology* / Q000821:virology; D024882:Drug Resistance, Viral; D005260:Female; D015774:Ganciclovir / Q000494:pharmacology*; D006801:Humans; D007694:Killer Cells, Natural / Q000276:immunology; D016176:T-Lymphocyte Subsets / Q000276:immunology; D013950:Thymus Gland / Q000502:physiology*
D000998:Antiviral Agents; D015774:Ganciclovir