Controlling the nano-bio interface to build collagen-silica self-assembled networks.
Bio-hybrid networks are designed based on the self-assembly of surface-engineered collagen-silica nanoparticles. Collagen triple helices can be confined on the surface of sulfonate-modified silica particles in a controlled manner. This gives rise to hybrid building blocks with well-defined diameters and surface potentials. Taking advantage of the self-assembling properties of collagen, collagen-silica networks are further built-up in solution. The structural and specific recognition properties of the collagen fibrils are well-preserved within the hybrid assembly. A combination of calorimetry, dynamic light scattering, zetametry and microscopy studies indicates that network formation occurs via a surface-mediated mechanism where pre-organization of the protein chains on the particle surface favors the fibrillogenesis process. These results enlighten the importance of the nano-bio interface on the formation and properties of self-assembled bionanocomposites.
UPMC Univ Paris 06, CNRS, Chimie de la Matière Condensée de Paris Collège de France, 11 place Marcelin Berthelot, F-75005 Paris, France. carole.aime@upmc.fr
Carole
C
Aimé
Gervaise
G
Mosser
Gaëlle
G
Pembouong
Laurent
L
Bouteiller
Thibaud
T
Coradin
D002151:Calorimetry; D003094:Collagen / Q000737:chemistry*; D006863:Hydrogen-Ion Concentration; D008027:Light; D053758:Nanoparticles / Q000737:chemistry*; D012542:Scattering, Radiation; D012822:Silicon Dioxide / Q000737:chemistry*; D013451:Sulfonic Acids / Q000737:chemistry; D013499:Surface Properties
D013451:Sulfonic Acids; D012822:Silicon Dioxide; D003094:Collagen