Common obesity-related genetic variants and papillary thyroid cancer risk.
BACKGROUND
Epidemiologic studies have shown consistent associations between obesity and increased thyroid cancer risk, but, to date, no studies have investigated the relationship between thyroid cancer risk and obesity-related single-nucleotide polymorphisms (SNP).


METHODS
We evaluated 575 tag SNPs in 23 obesity-related gene regions in a case-control study of 341 incident papillary thyroid cancer (PTC) cases and 444 controls of European ancestry. Logistic regression models, adjusted for attained age, year of birth, and sex were used to calculate ORs and 95% confidence intervals (CI) with SNP genotypes, coded as 0, 1, and 2 and modeled continuously to calculate P(trend).


RESULTS
Nine of 10 top-ranking SNPs (P(trend) < 0.01) were located in the FTO (fat mass and obesity associated) gene region, whereas the other was located in INSR (insulin receptor). None of the associations were significant after correcting for multiple testing.


CONCLUSIONS
Our data do not support an important role of obesity-related genetic polymorphisms in determining the risk of PTC.


CONCLUSIONS
Factors other than selected genetic polymorphisms may be responsible for the observed associations between obesity and increased PTC risk.
Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, EPS 7056, 6120 Executive Blvd, Rockville, MD 20852, USA. kitaharac@mail.nih.gov
Cari M
CM
Kitahara
Gila
G
Neta
Ruth M
RM
Pfeiffer
Deukwoo
D
Kwon
Li
L
Xu
Neal D
ND
Freedman
Amy A
AA
Hutchinson
Stephen J
SJ
Chanock
Erich M
EM
Sturgis
Alice J
AJ
Sigurdson
Alina V
AV
Brenner
D000328:Adult; D000368:Aged; D002277:Carcinoma / Q000453:epidemiology / Q000235:genetics*; D002291:Carcinoma, Papillary; D016022:Case-Control Studies; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000453:epidemiology / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D000077273:Thyroid Cancer, Papillary; D013964:Thyroid Neoplasms / Q000453:epidemiology / Q000235:genetics*; D014481:United States / Q000453:epidemiology; D055815:Young Adult