Biodegradable poly(lactide-co-glycolide) coatings on magnesium alloys for orthopedic applications.
Polymeric film coatings were applied by dip coating on two magnesium alloy systems, AZ31 and Mg4Y, in an attempt to slow the degradation of these alloys under in vitro conditions. Poly(lactic-co-glycolic acid) polymer in solution was explored at various concentrations, yielding coatings of varying thicknesses on the alloy substrates. Electrochemical corrosion studies indicate that the coatings initially provide some corrosion protection. Degradation studies showed reduced degradation over 3 days, but beyond this time point however, do not maintain a reduction in corrosion rate. Scanning electron microscopy indicates inhomogeneous coating durability, with gas pocket formation in the polymer coating, resulting in eventual detachment from the alloy surface. In vitro studies of cell viability utilizing mouse osteoblast cells showed improved biocompatibility of polymer coated substrates over the bare AZ31 and Mg4Y substrates. Results demonstrate that while challenges remain for long term degradation control, the developed polymeric coatings nevertheless provide short term corrosion protection and improved biocompatibility of magnesium alloys for possible use in orthopedic applications.
Department of Bioengineering, University of Pittsburgh, Pittsburgh, PA 15261, USA.
Nicole J
NJ
Ostrowski
Boeun
B
Lee
Abhijit
A
Roy
Madhumati
M
Ramanathan
Prashant N
PN
Kumta
D016475:3T3 Cells; D000497:Alloys; D000818:Animals; D020099:Coated Materials, Biocompatible; D008274:Magnesium / Q000737:chemistry*; D051379:Mice; D008855:Microscopy, Electron, Scanning; D009985:Orthopedics; D011098:Polyglactin 910 / Q000737:chemistry*; D017550:Spectroscopy, Fourier Transform Infrared
D000497:Alloys; D020099:Coated Materials, Biocompatible; D011098:Polyglactin 910; D008274:Magnesium