A case of pemphigoid gestationis with concurrent IgG antibodies to BP180, BP230 and type VII collagen.
A 22-year-old primigravida had a pruritic, erythematous, bullous eruption on the skin during the 26th week of gestation. After delivery the eruption flared up. The diagnosis of pemphigoid gestationis was confirmed based on histopathological and immunofluorescence findings. The result of immunoblotting showed IgG autoantibodies which reacted against BP230 in epidermal extracts and 290 kDa type VII collagen in dermal extracts. The BP180 antibodies were also detected by an enzyme-linked immunosorbent assay BP180NC16a diagnosis kit. Pulsed corticosteroid and cyclophosphamide resulted in a favourable response at the acute stage. The patient was cured in 2 years. The analysis of the patient's autoantibodies provides strong evidence for the involvement of epitope spreading in her autoimmune disease.
Shandong Provincial Institute of Dermatology and Venereology, Shandong Provincial Academy of Medical Science; Shandong Provincial Key Lab for Dermatovenereology.
Baoqi
B
Yang
Chong
C
Wang
Mei
M
Wu
Donghong
D
Du
Xiaoxiao
X
Yan
Guizhi
G
Zhou
Furen
F
Zhang
D001324:Autoantigens / Q000276:immunology*; D002352:Carrier Proteins / Q000276:immunology*; D024143:Collagen Type VII / Q000276:immunology*; D003598:Cytoskeletal Proteins / Q000276:immunology*; D000071821:Dystonin; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood*; D009419:Nerve Tissue Proteins / Q000276:immunology*; D024041:Non-Fibrillar Collagens / Q000276:immunology*; D006559:Pemphigoid Gestationis / Q000188:drug therapy / Q000276:immunology*; D011247:Pregnancy; D055815:Young Adult; D000097805:Collagen Type XVII
D001324:Autoantigens; D002352:Carrier Proteins; D024143:Collagen Type VII; D003598:Cytoskeletal Proteins; D000071821:Dystonin; D007074:Immunoglobulin G; D009419:Nerve Tissue Proteins; D024041:Non-Fibrillar Collagens; D000097805:Collagen Type XVII; C486268:DST protein, human