A luminescent and biocompatible photoCORM.
The water-soluble rhenium(I) complex fac-[Re(bpy)(CO)(3)(thp)](+) (1) [CF(3)SO(3)(-) salt; bpy = 2,2'-bipyridine, thp = tris(hydroxymethyl)phosphine] is both strongly luminescent and photoactive toward carbon monoxide release. It is stable in aerated aqueous media, is incorporated into cells from the human prostatic carcinoma cell line PPC-1, and shows no apparent cytotoxicity. Furthermore, the solvated Re(I) photoproduct of CO release (2) is also luminescent, a feature that allows one to track the transformation of 1 to 2 inside such cells using confocal fluorescence microscopy. In this context, 1 is a very promising candidate as a photoactivated CO releasing moiety (photoCORM) with potential therapeutic applications.
Department of Chemistry and Biochemistry, University of California, Santa Barbara, California 93106, USA.
Agustin E
AE
Pierri
Alessia
A
Pallaoro
Guang
G
Wu
Peter C
PC
Ford
D015082:2,2'-Dipyridyl / Q000737:chemistry* / Q000493:pharmacokinetics / Q000633:toxicity; D002248:Carbon Monoxide / Q000008:administration & dosage*; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D056831:Coordination Complexes / Q000737:chemistry / Q000493:pharmacokinetics / Q000633:toxicity; D006801:Humans; D049449:Luminescence; D049408:Luminescent Agents / Q000737:chemistry* / Q000493:pharmacokinetics / Q000633:toxicity; D010720:Phosphines / Q000737:chemistry* / Q000493:pharmacokinetics / Q000633:toxicity; D055668:Photochemical Processes; D012211:Rhenium / Q000737:chemistry* / Q000493:pharmacokinetics / Q000633:toxicity
D056831:Coordination Complexes; D049408:Luminescent Agents; D010720:Phosphines; D015082:2,2'-Dipyridyl; D012211:Rhenium; D002248:Carbon Monoxide