Echinocandin and ethanol lock therapy treatment of fungal catheter infections.
Ethanol lock therapy has been implemented to prevent infections of central venous catheters as well as to treat infections. Fungal catheter-associated blood stream infections are historically more difficult to treat and have required removal of central venous catheters. We report the largest case series to date, successfully treating 5 of 7 fungal catheter-associated blood stream infections with ethanol lock therapy and systemic echinocandin administration.
Department of Pediatrics, Division of Gastroenterology, Hepatology and Nutrition, Stanford University School of Medicine, Palo Alto, CA 94304, USA.
Kevin P
KP
Pieroni
Colleen
C
Nespor
Robert L
RL
Poole
John A
JA
Kerner
William E
WE
Berquist
D000935:Antifungal Agents / Q000627:therapeutic use*; D055499:Catheter-Related Infections / Q000188:drug therapy* / Q000517:prevention & control; D057785:Catheters / Q000382:microbiology*; D002648:Child; D002675:Child, Preschool; D004202:Disinfectants / Q000008:administration & dosage*; D004203:Disinfection / Q000379:methods; D054714:Echinocandins / Q000627:therapeutic use*; D000431:Ethanol / Q000008:administration & dosage*; D016469:Fungemia / Q000188:drug therapy* / Q000517:prevention & control; D005658:Fungi / Q000187:drug effects / Q000302:isolation & purification; D006801:Humans; D007223:Infant; D016896:Treatment Outcome; D055815:Young Adult
D000935:Antifungal Agents; D004202:Disinfectants; D054714:Echinocandins; D000431:Ethanol