Emergence of increased azithromycin resistance during unsuccessful treatment of Neisseria gonorrhoeae infection with azithromycin (Portland, OR, 2011).
We describe the emergence of an azithromycin-resistant Neisseria gonorrhoeae variant in a man from Portland, Oregon, during sole treatment with 2 g azithromycin. This report highlights the ease with which gonococcal macrolide resistance can emerge, the threat of multidrug resistant N. gonorrhoeae, and the need for adherence to Centers for Disease Control and Prevention treatment guidelines.
Neisseria Reference Laboratory, Department of Global Health and Center for AIDS and STD, University of Washington, Seattle, WA, USA.
Olusegun O
OO
Soge
Doug
D
Harger
Sean
S
Schafer
Kim
K
Toevs
Kathie A
KA
Raisler
Kathy
K
Venator
King K
KK
Holmes
Robert D
RD
Kirkcaldy
D000328:Adult; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D017963:Azithromycin / Q000494:pharmacology*; D002487:Centers for Disease Control and Prevention, U.S.; D024881:Drug Resistance, Bacterial / Q000187:drug effects; D005838:Genotype; D006069:Gonorrhea / Q000188:drug therapy* / Q000453:epidemiology; D019983:Guideline Adherence; D006801:Humans; D008297:Male; D008826:Microbial Sensitivity Tests; D009344:Neisseria gonorrhoeae / Q000187:drug effects* / Q000302:isolation & purification*; D009922:Oregon; D014481:United States
D000900:Anti-Bacterial Agents; D017963:Azithromycin