Long-term visual outcomes of penetrating keratoplasty for Peters anomaly.
BACKGROUND
To investigate the long-term results and visual outcomes of penetrating keratoplasty (PKP) in Peters anomaly.


METHODS
Twenty-three eyes from 22 patients with Peters anomaly who underwent PKP from 1998 to 2008 were reviewed retrospectively. Patients who were followed for more than 3 years after the first PKP were included in this study. The systemic and ophthalmic features of the recipients were assessed, and the various prognostic factors for graft survival were evaluated. Disease severity was determined according to other accompanying eye anomalies in mild or severe form. The final visual outcomes were presented with respect to graft clarity.


RESULTS
Among the 22 patients, 14 patients had unilateral disease, and eight patients had bilateral disease. Associated systemic anomalies were observed in six patients. The mean age at the first PKP was 42.4 months. Nineteen eyes (83 %) underwent PKP after 12 months of age. The graft failure rates at 1 year, 3 years, 5 years, and 10 years after PKP were 30 %, 39 %, 70 %, and 77 % respectively. Graft rejection within 1 month after PKP and severe disease were significant risk factors for graft failure. The mean final VAs in the clear-graft group and the failed-graft group were 1.883 logMAR and 2.767 logMAR (P < 0.001).


CONCLUSIONS
The results of delayed PKP in Peters anomaly were not inferior compared to the results of PKP performed at an earlier period in previous studies. If other congenital ophthalmic anomalies were present or graft rejection occurred within 1 month after PKP, the chance of graft failure was significantly increased.
Department of Ophthalmology, Inje University, Ilsan Paik Hospital, Goyang, Korea.
Ji Woong
JW
Chang
Mee Kum
MK
Kim
Jeong Hun
JH
Kim
Seong-Joon
SJ
Kim
Won Ryang
WR
Wee
Young Suk
YS
Yu
D000293:Adolescent; D000869:Anterior Eye Segment / Q000002:abnormalities / Q000503:physiopathology / Q000601:surgery; D002648:Child; D002675:Child, Preschool; D003315:Cornea / Q000502:physiology; D003318:Corneal Opacity / Q000503:physiopathology / Q000601:surgery*; D005124:Eye Abnormalities / Q000503:physiopathology / Q000601:surgery*; D005260:Female; D005500:Follow-Up Studies; D006085:Graft Survival / Q000502:physiology; D006801:Humans; D007223:Infant; D015948:Keratoplasty, Penetrating; D008297:Male; D012189:Retrospective Studies; D017211:Treatment Failure; D016896:Treatment Outcome; D014792:Visual Acuity / Q000502:physiology*