Interleukin-6 gene -174G>C and -636G>C promoter polymorphisms and prostate cancer risk.
Prostate cancer (PCa) is one of the most commonly diagnosed internal malignancies affecting men. Due to the important roles of IL-6 in different physiological and pathophysiological processes, IL-6 polymorphisms may modulate PCa risk. IL-6 -174 G>C (rs 1800795, also designated -236 G>C) and -636 G>C (rs 1800796, also designated -572 G>C) promoter polymorphisms have been implicated in PCa susceptibility, albeit still controversial. A literature search using PubMed and Highwire databases was conducted, resulting in eight case-control studies concerning the IL-6 -174 G>C polymorphism (11,613 PCa cases and 13,992 controls) and four case-control publications regarding the IL-6 -636 G>C polymorphism (1,941 PCa cases and 3,357 controls). In order to derive a more precise estimation, a meta-analysis based upon these selected case-control studies was performed. There was no significant association between IL-6 -174 G>C polymorphism and PCa increased risk. Nevertheless, the presence of allele C and the CC genotype were statistically significantly associated with decreased PCa risk in the overall analysis for IL-6 -636 G>C polymorphism. Additional studies in larger samples and analyses of functional repercussions of these SNPs in prostate tumor cells are necessary to validate these findings.
Centre of Genomics and Biotechnology, Institute for Biotechnology and Bioengineering, University of Trás-os-Montes and Alto Douro (CGB-UTAD/IBB), Quinta dos Prados, P.O. Box 1013, 5001-801 Vila Real, Portugal.
J F
JF
Magalhães
A J
AJ
Cortinhas
C M
CM
Albuquerque
C S
CS
Baptista
R
R
Ribeiro
Carlos
C
Viegas
Augusto
A
Matos
João
J
Machado
Maria A
MA
Pires
Henrique
H
Guedes-Pinto
A
A
Martins-Bessa
J C
JC
Leitão
E
E
Bastos
D016022:Case-Control Studies; D020022:Genetic Predisposition to Disease; D006801:Humans; D015850:Interleukin-6 / Q000235:genetics*; D008297:Male; D020641:Polymorphism, Single Nucleotide; D044382:Population Groups / Q000235:genetics; D011401:Promoter Regions, Genetic; D011471:Prostatic Neoplasms / Q000235:genetics*; D017594:Publication Bias
D015850:Interleukin-6