Susceptibility testing of Streptococcus pneumoniae and Viridans streptococcal isolates against: quinolones, oxazolidinones and glycopeptides.
The aim of this study was to test the susceptibility of 100 strains (pneumococci and viridans streptococci) isolated from oral and respiratory tract infections and their complications, against one antibiotic of each of the following classes: quinolones, oxazolidinones and glycopeptides.


METHODS
The Etest has been used in order to investigate the susceptibility of the isolates against levofloxacin, linezolid and vancomycin.


CONCLUSIONS
As expected, the results of the study indicated that all isolates were susceptible to linezolid and vancomycin. In contrast to the pneumococcal isolates, which were all susceptible to levofloxacin, 10% of the viridans strains showed resistance to this quinolone. When fluoroquinolones are needed as an alternative to the beta-lactam antibiotics in infections in which oral streptococci are involved, the in vitro susceptibility testing is required.
University of Medicine and Pharmacy "Carol Davila", Bucharest.
Gabriela
G
Băncescu
Amalia-Sofia
AS
Neagu
Manuela
M
Radu-Popescu
Maria
M
Nica
Amalia
A
Dascălu
Irina
I
Nistor
Stefania-Felicia
SF
Bărbuceanu
A
A
Băncescu
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D000890:Anti-Infective Agents / Q000494:pharmacology*; D006020:Glycopeptides / Q000494:pharmacology*; D006801:Humans; D008826:Microbial Sensitivity Tests / Q000379:methods; D023303:Oxazolidinones / Q000494:pharmacology*; D015363:Quinolones / Q000494:pharmacology*; D012141:Respiratory Tract Infections / Q000188:drug therapy / Q000382:microbiology; D013296:Streptococcus pneumoniae / Q000187:drug effects* / Q000302:isolation & purification; D034363:Viridans Streptococci / Q000187:drug effects* / Q000302:isolation & purification
D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents; D006020:Glycopeptides; D023303:Oxazolidinones; D015363:Quinolones