Dynein: a force (generation mechanism) to be reckoned with.
In this issue of Structure, Roberts et al. discuss how cryo-electron microscopy single particle reconstructions of the microtubule-based motor dynein reveal dramatic nucleotide-dependent conformational changes. They provide insight into dynein force generation and hint at shared mechanisms with other AAA+ unfoldases.
Institute of Structural and Molecular Biology, Birkbeck College, London WC1E 7HX, UK. c.moores@mail.cryst.bbk.ac.uk
Carolyn A
CA
Moores