Synthesis of polycyclic isoindoline derivatives via tandem Pd-catalyzed coupling, propargyl-allenyl isomerization, [4 + 2] cycloaddition and aromatization reaction.
We report in this paper an interesting sequential reaction involving sequential Sonogashira coupling, propargyl-allenyl isomerization, [4 + 2] cycloaddition and aromatization reaction, which provides a facile method for the synthesis of a variety of polycyclic isoindoline derivatives from easily accessible starting materials.
Department of Chemistry, Zhejiang University, Hangzhou 310028, P. R. China.
Shugao
S
Zhu
Jian
J
Cao
Luling
L
Wu
Xian
X
Huang
D002384:Catalysis; D061565:Cycloaddition Reaction; D054833:Isoindoles / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D010165:Palladium / Q000737:chemistry*; D010293:Pargyline / Q000031:analogs & derivatives* / Q000737:chemistry*; D011083:Polycyclic Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D013237:Stereoisomerism
D054833:Isoindoles; D011083:Polycyclic Compounds; D010165:Palladium; D010293:Pargyline