[Primary biliary cirrhosis-autoimmune hepatitis overlap syndrome in a patient with chronic hepatitis B infection].
We describe the case of a female patient with a previous diagnosis of primary biliary cirrhosis (PBC) and chronic hepatitis B in inactive phase who developed increased transaminase levels with no evidence of hepatitis B virus reactivation while receiving ursodeoxycholic acid treatment. A liver biopsy showed changes compatible with overlapping autoimmune hepatitis (AIH). Budesonide treatment achieved normalization of transaminase levels. We provide a review of PBC and AIH overlap syndrome and discuss the particular features of this case that led us to this diagnosis, as well as the treatment provided.
Unidad de Digestivo, Hospital Universitario Infanta Sofía, San Sebastián de los Reyes, Madrid, España. onumar@gmail.com
Óscar
Ó
Núñez Martínez
Isabel
I
Marquina Ibáñez
Elena
E
Ruiz Bravo-Burguillos
Alfonso
A
Encinas Sotillos
José Carlos
JC
Erdozaín Sosa
D005260:Female; D019694:Hepatitis B, Chronic / Q000150:complications*; D019693:Hepatitis, Autoimmune / Q000150:complications*; D006801:Humans; D008105:Liver Cirrhosis, Biliary / Q000150:complications*; D008875:Middle Aged; D013577:Syndrome