Beside the MEF2 axis: unconventional functions of HDAC4.
The class IIa deacetylase HDAC4 is unequivocally known as a negative regulator of MEF2-dependent transcription. In the past years several works have allowed us to understand how different signals, mirroring specific environmental circumstances keep in check the repressive action of HDAC4 against MEF2s. At the same time, pieces of evidence have gradually accumulated about HDAC4 activities emancipated from MEF2s. The aim of this review is to discuss about these "unconventional functions" of HDAC4.
Dipartimento di Scienze Mediche e Biologiche and MATI Center of Excellence, Università degli Studi di Udine, P.le Kolbe 4-33100 Udine, Italy.
Andrea
A
Clocchiatti
Eros
E
Di Giorgio
Francesca
F
Demarchi
Claudio
C
Brancolini
D051792:Basic Helix-Loop-Helix Proteins / Q000378:metabolism; D051858:Forkhead Transcription Factors / Q000378:metabolism; D006655:Histone Deacetylases / Q000378:metabolism*; D006801:Humans; D018006:Myogenic Regulatory Factors / Q000235:genetics / Q000378:metabolism*; D011485:Protein Binding; D012097:Repressor Proteins / Q000378:metabolism*; D050794:STAT1 Transcription Factor / Q000378:metabolism; D014158:Transcription, Genetic
D051792:Basic Helix-Loop-Helix Proteins; D051858:Forkhead Transcription Factors; D006655:Histone Deacetylases; D018006:Myogenic Regulatory Factors; D012097:Repressor Proteins; D050794:STAT1 Transcription Factor; C400300:HDAC4 protein, human