Methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism and age at onset of schizophrenia: no consistent evidence for an association in the Nordic population.
Methylenetetrahydrofolate reductase (MTHFR) is an enzyme involved in metabolic pathways of importance for nucleotide synthesis and methylation of DNA, membranes, proteins and lipids. The MTHFR gene includes a common polymorphism (rs1801133 or C677T), which is associated with enzyme activity. The T-allele of the C677T polymorphism has been associated with earlier age at onset of schizophrenia in a Scandinavian population, although no association was found in replication attempts in other populations. Extending the study to five Nordic samples consisting of 2,198 patients with schizophrenia, including the original Scandinavian samples, there was no significant association between MTHFR C677T polymorphism and age at onset in schizophrenia. The present results do not suggest that the investigated MTHFR polymorphism has any significant influence on age at onset of schizophrenia in the Nordic population.
Department of Clinical Neuroscience, Karolinska Institutet and Hospital, Stockholm, Sweden.
Peter
P
Saetre
Jakob
J
Grove
Anders D
AD
Børglum
Ole
O
Mors
Thomas
T
Werge
Ole A
OA
Andreassen
Maria
M
Vares
Ingrid
I
Agartz
Lars
L
Terenius
Erik G
EG
Jönsson
D017668:Age of Onset; D005260:Female; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008297:Male; D042965:Methylenetetrahydrofolate Reductase (NADPH2) / Q000235:genetics*; D009664:Norway / Q000453:epidemiology; D020641:Polymorphism, Single Nucleotide; D012559:Schizophrenia / Q000453:epidemiology* / Q000235:genetics*
C573423:MTHFR protein, human; D042965:Methylenetetrahydrofolate Reductase (NADPH2)