The role of VEGF and KDR polymorphisms in moyamoya disease and collateral revascularization.
We conducted a case-control study to investigate whether vascular endothelial growth factor (VEGF -2578, -1154, -634, and 936) and kinase insert domain containing receptor (KDR -604, 1192, and 1719) polymorphisms are associated with moyamoya disease. Korean patients with moyamoya disease (n = 107, mean age, 20.9±15.9 years; 66.4% female) and 243 healthy control subjects (mean age, 23.0±16.1 years; 56.8% female) were included. The subjects were divided into pediatric and adult groups. Among the 64 surgical patients, we evaluated collateral vessel formation after 2 years and divided patients into good (collateral grade A) or poor (collateral grade B and C) groups. The frequencies and distributions of four VEGF (-2578, -1154, -634, and 936) and KDR (-604, 1192, and 1719) polymorphisms were assessed from patients with moyamoya disease and compared to the control group. No differences were observed in VEGF -2578, -1154, -634, and 936 or KDR -604, 1192, and 1719 polymorphisms between the control group and moyamoya disease group. However, we found the -634CC genotype occurred less frequently in the pediatric moyamoya group (p = 0.040) whereas the KDR -604C/1192A/1719T haplotype increased the risk of pediatric moyamoya (p = 0.024). Patients with the CC genotype of VEGF -634 had better collateral vessel formation after surgery. Our results suggest that the VEGF -634G allele is associated with pediatric moyamoya disease and poor collateral vessel formation.
Department of Neurosurgery, CHA Bundang Medical Center, CHA University School of Medicine, Seongnam, South Korea.
Young Seok
YS
Park
Young Joo
YJ
Jeon
Hyun Seok
HS
Kim
Kyu Young
KY
Chae
Seung-Hun
SH
Oh
In Bo
IB
Han
Hyun Sook
HS
Kim
Won-Chan
WC
Kim
Ok-Joon
OJ
Kim
Tae Gon
TG
Kim
Joong-Uhn
JU
Choi
Dong-Seok
DS
Kim
Nam Keun
NK
Kim
D000293:Adolescent; D000328:Adult; D044466:Asian People / Q000235:genetics; D002339:Carotid Arteries / Q000378:metabolism / Q000503:physiopathology*; D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D005260:Female; D006239:Haplotypes; D006801:Humans; D008297:Male; D009072:Moyamoya Disease / Q000235:genetics* / Q000503:physiopathology*; D018919:Neovascularization, Physiologic; D020641:Polymorphism, Single Nucleotide; D042461:Vascular Endothelial Growth Factor A / Q000235:genetics*; D040301:Vascular Endothelial Growth Factor Receptor-2 / Q000235:genetics*; D055815:Young Adult
D042461:Vascular Endothelial Growth Factor A; D040301:Vascular Endothelial Growth Factor Receptor-2