Influence of age and CD4+ T cell counts on the prevalence of genital human papillomavirus infection among HIV-seropositive men who have sex with men in Taiwan.
This study aimed to examine the baseline prevalence of genital human papillomavirus (HPV) infection among human immunodeficiency virus (HIV)-seropositive men who have sex with men in Taiwan and to determine the association of age and CD4+ T cell counts with HPV infection. In 2010, 305 men who have sex with men infected with HIV and 100 HIV-seronegative men who have sex with men were recruited. Genital swabs were collected and 37 HPV genotypes were detected using linear array HPV genotyping. HPV infection was present in 45.3% of the patients infected with HIV and in 18% of the HIV-negative subjects (P < 0.001). HPV types 52, 51, and 16 were the most commonly identified oncogenic types. Oncogenic HPV types were identified in 31.2% of the patients infected with HIV and in 13% of the seronegative subjects (P < 0.001). Adjusted odd ratios (ORs) for the detection of any HPV type were 2.9 (95% confidence interval [CI], 1.4-5.9) for men who have sex with men aged 30-34 and 2.1 (95% CI, 1.1-4.3) for those aged >35 compared with that for those aged <25. ORs were 2.8 (95% CI, 1.0-7.4) for a CD4+ T cell count of 200-350 cells/µl and 8.5 (95% CI, 2.9-24.5) for a CD4+ T cell count of <200 cells/µl compared with that for seronegative subjects. In conclusion, this novel HPV study, carried out in Northern Taiwan on men who have sex with men, revealed that age and immune state were associated significantly and independently with HPV infection.
School of Public Health, College of Public Health and Nutrition, Taipei Medical University, Taipei, Taiwan.
Shu-Hsing
SH
Cheng
Fang-Yeh
FY
Chu
Yu-Shiang
YS
Lin
Yu-Mei
YM
Hsueh
D000328:Adult; D000367:Age Factors; D052685:Alphapapillomavirus / Q000145:classification / Q000472:pathogenicity; D023241:Antiretroviral Therapy, Highly Active; D018791:CD4 Lymphocyte Count; D060085:Coinfection / Q000175:diagnosis / Q000821:virology*; D015658:HIV Infections / Q000188:drug therapy / Q000821:virology; D018023:HIV Seronegativity; D006679:HIV Seropositivity / Q000821:virology; D015497:HIV-1 / Q000276:immunology* / Q000472:pathogenicity; D018451:Homosexuality, Male; D006801:Humans; D015994:Incidence; D016015:Logistic Models; D008297:Male; D016017:Odds Ratio; D030361:Papillomavirus Infections / Q000453:epidemiology* / Q000821:virology; D011237:Predictive Value of Tests; D015995:Prevalence; D012307:Risk Factors; D013624:Taiwan / Q000453:epidemiology; D055815:Young Adult