Immunodominance of HLA-B27-restricted HIV KK10-specific CD8(+) T-cells is not related to naïve precursor frequency.
The factors that determine the immunodominance, efficacy and almost ubiquitous presence of CD8(+) T-cell responses to the HLA-B27-restricted HIV-1 p24 Gag-derived KK10 epitope remain to be fully elucidated. Here, we show that neither the precursor frequency nor the priming capacity of KK10-reactive CD8(+) T-cells within the naïve pool differ substantially in comparison to other specificities. These data implicate alternative mechanisms in the relative protection conferred by CD8(+) T-cell responses to this epitope.
INSERM UMR S 945, Infections and Immunity, Université Pierre et Marie Curie-Paris 6, Hôpital Pitié-Salpêtrière, Paris, France.
Maria Candela
MC
Iglesias
Olivia
O
Briceno
Emma
E
Gostick
Arnaud
A
Moris
Céline
C
Meaudre
David A
DA
Price
Marie-Noëlle
MN
Ungeheuer
Asier
A
Saez-Cirion
Roberto
R
Mallone
Victor
V
Appay
D018414:CD8-Positive T-Lymphocytes / Q000276:immunology*; D018984:Epitopes, T-Lymphocyte / Q000276:immunology*; D005260:Female; D016655:HIV Core Protein p24 / Q000276:immunology*; D015497:HIV-1 / Q000276:immunology*; D015796:HLA-B27 Antigen / Q000276:immunology*; D006801:Humans; D008297:Male
D018984:Epitopes, T-Lymphocyte; D016655:HIV Core Protein p24; D015796:HLA-B27 Antigen; C514799:p24 protein, Human Immunodeficiency Virus Type 1