Association study of gene LPP in women with polycystic ovary syndrome.
BACKGROUND
Previous genome-wide association study (GWAS) of polycystic ovary syndrome (PCOS) in Han Chinese population has found that SNPs in LPP gene were nominally significant in PCOS patients (P around 10E-05). Replication of the GWAS was applied to further confirm the relationship between LPP gene and PCOS.


METHODS
Three polymorphisms of LPP gene (rs715790, rs4449306, rs6782041) were selected and replicated in additional 1132 PCOS cases and 1142 controls. Genotyping of LPP gene was carried out by Taqman-MGB method.


RESULTS
In rs715790, the allele frequency is significantly different between the PCOS group and the control group. Meta-analysis showed that the allele frequencies of the three SNPs rs715790 (P(meta) =1.89E-05, OR=1.23), rs4449306 (P(meta) =3.0E-04, OR=1.10), rs6782041 (P(meta) = 2.0E-04, OR=1.09), were significantly different between PCOS cases and controls.


CONCLUSIONS
Our results suggest that LPP gene might be a novel candidate for PCOS.
Center for Reproductive Medicine, Provincial Hospital Affiliated to Shandong University, Jinan, China.
Bo
B
Zhang
Han
H
Zhao
Tao
T
Li
Xuan
X
Gao
Qin
Q
Gao
Rong
R
Tang
Jiangtao
J
Zhang
Zi-Jiang
ZJ
Chen
D003598:Cytoskeletal Proteins / Q000235:genetics*; D005260:Female; D055106:Genome-Wide Association Study; D006801:Humans; D060588:LIM Domain Proteins / Q000235:genetics*; D011085:Polycystic Ovary Syndrome / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D020133:Reverse Transcriptase Polymerase Chain Reaction
D003598:Cytoskeletal Proteins; D060588:LIM Domain Proteins; C103594:LPP protein, human