Metabolic and structural impairment of skeletal muscle in heart failure.
Physiologic endurance exercise performance is primarily limited by cardiac function. In patients with heart failure, there is dissociation between cardiac performance and exercise capacity, suggesting a distinct role of abnormal peripheral organ function, including skeletal muscle function. The impact of heart failure upon skeletal muscle and exercise performance will be discussed with a focus on molecular, structural, and functional derangements in skeletal muscle of patients with heart failure.
Division of Cardiology, Department of Medicine, Center for Advanced Cardiac Care, Columbia University Medical Center, 622 West 168th Street, PH 10, Room 203, New York, NY, 10032, USA.
Cynthia
C
Zizola
P Christian
PC
Schulze
D000818:Animals; D004734:Energy Metabolism; D006333:Heart Failure / Q000378:metabolism* / Q000473:pathology; D006801:Humans; D018482:Muscle, Skeletal / Q000378:metabolism* / Q000473:pathology; D032383:Myocytes, Cardiac / Q000378:metabolism* / Q000473:pathology*