Clinical usefulness of doripenem (DRPM), a carbapenem antimicrobial drug, for the treatment of patients with acute cholangitis: retrospective study.
OBJECTIVE
We investigated the usefulness of doripenem (DRPM), a carbapenem antimicrobial drug, for the treatment of acute cholangitis.


METHODS
28 patients who received a diagnosis of moderate or severe cholangitis were included in this investigation. 23 patients had moderate cholangitis; 5 patients had severe cholangitis. When moderate or severe cholangitis was diagnosed, administration of DRPM and endoscopic drainage were performed. The dose of DRPM was fixed at 0.5 g, 3 times daily. Evaluation of clinical findings (abdominal pain and body temperature) and blood test findings (WBC, CRP, ALT, ALP, and T-Bil) was performed before and on Day 5 after administration.


RESULTS
Endoscopic drainage was successful in all patients. After administration of DRPM, a significant improvement was observed in all endpoints of both clinical findings and blood test findings (p < 0.05). No adverse events due to administration of DRPM were observed.


CONCLUSIONS
It was suggested that administration of DRPM may be clinically useful for the treatment of moderate and severe cholangitis.
Department of Medicine and Clinical Oncology, Graduate School of Medicine, Chiba University, Japan. sakai4754@yahoo.co.jp
Yuji
Y
Sakai
Toshio
T
Tsuyuguchi
Kazuki
K
Kato
Harutoshi
H
Sugiyama
Takao
T
Nishikawa
Makoto
M
Takahashi
Osamu
O
Yokosuka
D000208:Acute Disease; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000890:Anti-Infective Agents / Q000627:therapeutic use*; D015780:Carbapenems / Q000627:therapeutic use*; D002761:Cholangitis / Q000188:drug therapy*; D000077726:Doripenem; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D012720:Severity of Illness Index; D016896:Treatment Outcome
D000890:Anti-Infective Agents; D015780:Carbapenems; D000077726:Doripenem