Copper-catalyzed ortho-acylation of phenols with aryl aldehydes and its application in one-step preparation of xanthones.
In the presence of triphenylphosphine, copper(II) chloride can catalyze an intermolecular ortho-acylation reaction of phenols with aryl aldehydes. The reaction proceeds smoothly with a wide range of starting materials, and furthermore, it can be used to synthesize xanthone derivatives in a single step in high yields.
Department of Chemistry and Biochemistry, University of South Carolina, Columbia, SC 29208, USA.
Jun
J
Hu
Enoch A
EA
Adogla
Yong
Y
Ju
Daping
D
Fan
Qian
Q
Wang
D000215:Acylation; D000447:Aldehydes / Q000737:chemistry*; D002384:Catalysis; D003300:Copper / Q000737:chemistry*; D009943:Organophosphorus Compounds / Q000737:chemistry; D044004:Xanthones / Q000138:chemical synthesis / Q000737:chemistry*
D000447:Aldehydes; D009943:Organophosphorus Compounds; D044004:Xanthones; C061896:triphenylphosphine; D003300:Copper