The effects of topical treatment with curcumin on burn wound healing in rats.
The present study was designed to determine the role of topical treatment with curcumin (Cur) on burn wound healing in rats. The Wistar-albino rats were randomly allotted into one of three experimental groups: 4th, 8th and 12th day (post burn) and all groups include subgroups which Burn and Burn + Cur. Each group contains 12 animals. Burn wounds were made on the back of rat and Cur was administered topically. At the end of the study, all animals were sacrificed and the wound tissues removed for analyse to biochemical and histopathological changes. There was a significant increase in the hydroxyproline levels in the skin of the Cur groups. Cur treated wounds were found to heal much faster as indicated by improved rates of inflammatory cells, collagen deposition, angiogenesis, granulation tissue formation and epithelialization which were also confirmed by histopathological and biochemical examinations. Our data also indicate that there is a rise in the expression of proliferating cell nuclear antigen in skin tissues of Cur-treated rats in the Burn group. The results clearly substantiate the beneficial effects of the topical application of Cur in the acceleration of wound healing.
Department of Dermatology, Namik Kemal University, Tekirdag, Turkey. mkulac@nku.edu.tr
Mustafa
M
Kulac
Cevat
C
Aktas
Feti
F
Tulubas
Ramazan
R
Uygur
Mehmet
M
Kanter
Mustafa
M
Erboga
Mehmet
M
Ceber
Birol
B
Topcu
Oguz Aslan
OA
Ozen
D000287:Administration, Topical; D000818:Animals; D002056:Burns / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology; D003474:Curcumin / Q000008:administration & dosage*; D006909:Hydroxyproline / Q000378:metabolism; D051381:Rats; D012867:Skin / Q000293:injuries / Q000378:metabolism / Q000473:pathology; D014945:Wound Healing / Q000187:drug effects*
D003474:Curcumin; D006909:Hydroxyproline