A prion-mediated mechanism for memory proposed in Drosophila.
Memories are remarkably persistent, but rely on transient signaling. The prion-like properties of CPEB suggested a solution to this problem. The paper by Krüttner et al. (2012) in this issue of Neuron demonstrates that the prion-like domain of Drosophila CPEB functions independently of its RNA-binding domain for memory.
Laboratory of Genetics, The Rockefeller University, 1230 York Avenue, New York, NY 10065, USA.
Wanhe
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Li
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Dubnau