Thrombocytopenia associated with one type of polysulfone hemodialysis membrane: a report of 5 cases.
Much progress has been made in the biocompatibility of hemodialysis membranes with the development of synthetic membranes. However, despite better biocompatibility, thrombocytopenia has been observed in patients who are dialyzed with various polysulfone membranes. Recent publications have attributed this phenomenon to the electron-beam sterilization of dialyzers. We report 5 cases of thrombocytopenia in patients treated by hemodialysis with an electron-beam sterilized polysulfone membrane. The thrombocytopenia resolved after switching to either of 2 polysulfone membranes, one of which also was electron-beam sterilized. Although we were unable to elucidate the exact biochemical mechanism, the cause of the thrombocytopenia in this series appears to be related to the type of polysulfone and not due to the sterilization technique.
Department of Internal Medicine, Temple University School of Medicine, Philadelphia, PA 19140, USA. luyikao.deprada@tuhs.temple.edu
Luyi
L
De Prada
Jean
J
Lee
Avrum
A
Gillespie
Joseph
J
Benjamin
D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D015994:Incidence; D007676:Kidney Failure, Chronic / Q000628:therapy*; D008297:Male; D008567:Membranes, Artificial; D008875:Middle Aged; D011108:Polymers / Q000009:adverse effects* / Q000627:therapeutic use; D006435:Renal Dialysis / Q000295:instrumentation; D013242:Sterilization / Q000379:methods; D013450:Sulfones / Q000009:adverse effects* / Q000627:therapeutic use; D013921:Thrombocytopenia / Q000453:epidemiology* / Q000517:prevention & control; D016896:Treatment Outcome
D008567:Membranes, Artificial; D011108:Polymers; D013450:Sulfones; C017662:polysulfone P 1700; C022840:polyether sulfone