Leishmania promastigotes: building a safe niche within macrophages.
Upon their internalization by macrophages, Leishmania promastigotes inhibit phagolysosome biogenesis. The main factor responsible for this inhibition is the promastigote surface glycolipid lipophosphoglycan (LPG). This glycolipid has a profound impact on the phagosome, causing periphagosomal accumulation of F-actin and disruption of phagosomal lipid microdomains. Functionally, this LPG-mediated inhibition of phagosome maturation is characterized by an impaired assembly of the NADPH oxidase and the exclusion of the vesicular proton-ATPase from phagosomes. In this chapter, we review the current knowledge concerning the nature of the intra-macrophage compartment in which Leishmania donovani promastigotes establish infection. We also describe how LPG enables this parasite to remodel the parasitophorous vacuole.
INRS - Institut Armand-Frappier and Center for Host-Parasite Interactions Laval, QC, Canada.
Neda
N
Moradin
Albert
A
Descoteaux
D000818:Animals; D054884:Host-Pathogen Interactions; D006801:Humans; D007893:Leishmania donovani / Q000472:pathogenicity*; D008264:Macrophages / Q000469:parasitology*; D019255:NADPH Oxidases / Q000037:antagonists & inhibitors; D010588:Phagosomes / Q000469:parasitology*; D006180:Proton-Translocating ATPases / Q000037:antagonists & inhibitors
D019255:NADPH Oxidases; D006180:Proton-Translocating ATPases