Diffusion-weighted MRI and PSA correlations in patients with prostate cancer treated with radiation and hormonal therapy.
OBJECTIVE
To investigate the correlation between signal intensity (SI) on diffusion-weighted imaging (DWI) and the levels of prostate-specific antigen (PSA) in patients with prostate cancer treated with radiation and hormonal therapy.


METHODS
Forty-four patients with prostate cancer treated with hormonal therapy and radiation therapy were evaluated. Areas with high SI on DWI were detected and the apparent diffusion co-efficient (ADC) values were measured. The ADC values and PSA levels were compared between patients with high-DWI SI and patients with a normal DWI signal.


RESULTS
Fourteen patients had high SI on DWI. The mean ADC value in these cancerous lesions was lower than in non-cancerous tissues. The mean PSA level in patients with high-DWI SI was significantly higher than in patients with a normal signal.


CONCLUSIONS
The present results suggest that SI on DWI appears to correlate with PSA levels in patients with prostate cancer treated with radiation and hormonal therapy.
Department of Radiology, Graduate School of Medical science, University of the Ryukyus, 207 Uehara, Nishihara-cho, Okinawa 903-0215, Japan. irayu@med.u-ryukyu.ac.jp
Yuko
Y
Iraha
Sadayuki
S
Murayama
Ayano
A
Kamiya
Shiro
S
Iraha
Kazuhiko
K
Ogawa
D000368:Aged; D000369:Aged, 80 and over; D000726:Androgen Antagonists / Q000627:therapeutic use; D018931:Antineoplastic Agents, Hormonal / Q000627:therapeutic use*; D059248:Chemoradiotherapy; D038524:Diffusion Magnetic Resonance Imaging / Q000379:methods*; D007987:Gonadotropin-Releasing Hormone / Q000031:analogs & derivatives / Q000627:therapeutic use; D006801:Humans; D008297:Male; D008875:Middle Aged; D017430:Prostate-Specific Antigen / Q000097:blood*; D011471:Prostatic Neoplasms / Q000188:drug therapy / Q000532:radiotherapy; D012189:Retrospective Studies; D016896:Treatment Outcome
D000726:Androgen Antagonists; D018931:Antineoplastic Agents, Hormonal; D007987:Gonadotropin-Releasing Hormone; D017430:Prostate-Specific Antigen