Acquired factor V inhibitor developing in a patient with esophageal squamous cell carcinoma.
An 82-year-old man referred to our medical ward because of epistaxis and melena was found to have 12 Bethesda units of factor V inhibitor. He was managed for bleeding with supportive care, followed by corticosteroid therapy. The bleeding completely stopped 1 week after corticosteroid therapy. Medical history revealed dysphagia during the past 6 months and further evaluation brought to light a squamous cell carcinoma (SCC) in the esophagus. This is the first case of an acquired factor V inhibitor developing in a patient with esophageal SCC without any other risk factors such as surgery.
Minoo
M
Ahmadinejad
Reference Coagulation Laboratory, Iranian Blood Transfusion Organization Research Center, Tehran University of Medical Sciences, Tehran, Iran. minooam@gmail.com
Ahmadinejad
A
Minoo
Nader
N
Roushan
Roushan
R
Nader
D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D000369:Aged, 80 and over; D001323:Autoantibodies / Q000096:biosynthesis / Q000276:immunology*; D001327:Autoimmune Diseases / Q000209:etiology / Q000276:immunology*; D002294:Carcinoma, Squamous Cell / Q000150:complications / Q000175:diagnosis / Q000000981:diagnostic imaging / Q000276:immunology* / Q000532:radiotherapy; D003680:Deglutition Disorders / Q000209:etiology; D057210:Delayed Diagnosis; D004844:Epistaxis / Q000209:etiology; D017707:Erythrocyte Transfusion; D004938:Esophageal Neoplasms / Q000150:complications / Q000175:diagnosis / Q000000981:diagnostic imaging / Q000276:immunology* / Q000532:radiotherapy; D005165:Factor V / Q000037:antagonists & inhibitors / Q000276:immunology*; D005166:Factor V Deficiency / Q000209:etiology / Q000276:immunology*; D017809:Fatal Outcome; D005773:Gastroscopy; D006417:Hematuria / Q000209:etiology; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D016682:Lupus Coagulation Inhibitor / Q000097:blood; D008297:Male; D008551:Melena / Q000209:etiology; D010257:Paraneoplastic Syndromes / Q000209:etiology / Q000276:immunology*; D011239:Prednisolone / Q000627:therapeutic use; D011859:Radiography
D000305:Adrenal Cortex Hormones; D001323:Autoantibodies; D007166:Immunosuppressive Agents; D016682:Lupus Coagulation Inhibitor; D005165:Factor V; D011239:Prednisolone