Synthesis of polysubstituted β-amino cyclohexane carboxylic acids via Diels-Alder reaction using Ni(II)-complex stabilized β-alanine derived dienes.
This paper describes the design and synthesis of a new class of β-alanine derived dienes stabilized by Ni(II)-complex. Preliminary study of their Diels-Alder cycloaddition reactions with several types of dienophiles demonstrates their significant synthetic potential for the preparation of various polyfunctional β-aminocyclohexane carboxylic acids.
State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 555 Zu Chong Zhi Road, Shanghai 201203, People's Republic of China.
Xiao
X
Ding
Hengshuai
H
Wang
Jiang
J
Wang
Sinan
S
Wang
Daizong
D
Lin
Li
L
Lv
Yu
Y
Zhou
Xiaomin
X
Luo
Hualiang
H
Jiang
José Luis
JL
Aceña
Vadim A
VA
Soloshonok
Hong
H
Liu
D000598:Amino Acids, Cyclic / Q000138:chemical synthesis* / Q000737:chemistry; D002384:Catalysis; D061565:Cycloaddition Reaction; D003509:Cyclohexanecarboxylic Acids / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D009532:Nickel / Q000737:chemistry*; D015091:beta-Alanine / Q000737:chemistry*
D000598:Amino Acids, Cyclic; D003509:Cyclohexanecarboxylic Acids; D015091:beta-Alanine; D009532:Nickel