Tools for mapping high-throughput sequencing data.
BACKGROUND
A ubiquitous and fundamental step in high-throughput sequencing analysis is the alignment (mapping) of the generated reads to a reference sequence. To accomplish this task, numerous software tools have been proposed. Determining the mappers that are most suitable for a specific application is not trivial.


RESULTS
This survey focuses on classifying mappers through a wide number of characteristics. The goal is to allow practitioners to compare the mappers more easily and find those that are most suitable for their specific problem.
EMBL Outstation, European Bioinformatics Institute (EBI), Hinxton, Cambridge CB10 ISD, UK. nf@ebi.ac.uk
Nuno A
NA
Fonseca
Johan
J
Rung
Alvis
A
Brazma
John C
JC
Marioni
D000465:Algorithms; D014644:Genetic Variation; D059014:High-Throughput Nucleotide Sequencing; D006801:Humans; D016415:Sequence Alignment; D017422:Sequence Analysis, DNA; D017423:Sequence Analysis, RNA; D012984:Software