Small-molecule inhibitors of the interaction between the E3 ligase VHL and HIF1α.
Department of Chemistry, Yale University, New Haven, CT 06511, USA.
Dennis L
DL
Buckley
Jeffrey L
JL
Gustafson
Inge
I
Van Molle
Anke G
AG
Roth
Hyun Seop
HS
Tae
Peter C
PC
Gareiss
William L
WL
Jorgensen
Alessio
A
Ciulli
Craig M
CM
Crews
D018360:Crystallography, X-Ray; D015195:Drug Design; D004791:Enzyme Inhibitors / Q000737:chemistry* / Q000494:pharmacology*; D006801:Humans; D051795:Hypoxia-Inducible Factor 1, alpha Subunit / Q000037:antagonists & inhibitors / Q000378:metabolism*; D020128:Inhibitory Concentration 50; D008958:Models, Molecular; D060066:Protein Interaction Maps / Q000187:drug effects*; D051794:Von Hippel-Lindau Tumor Suppressor Protein / Q000037:antagonists & inhibitors* / Q000737:chemistry / Q000378:metabolism*
D004791:Enzyme Inhibitors; D051795:Hypoxia-Inducible Factor 1, alpha Subunit; D051794:Von Hippel-Lindau Tumor Suppressor Protein; C497446:VHL protein, human