[Analysis on iodine nutritional status and thyroid function in pregnant women].
OBJECTIVE
To investigate the iodine nutritional status and thyroid function of pregnant women during different periods of pregnancy, to provide evidence for guiding iodine supplementation for them.


METHODS
A cross-sectional survey was performed in 90 pregnant women in Wuwei City from April 2009 to January 2010. The morning blood samples and random urine samples were collected, and the thyroid-stimulating hormone (TSH), free triiodothyronine (FT3), free thyroid hormone (FT4), thyroglobulin antibodies (TGAb), thyroid microsomal antibodies (TMAb) in blood samples and iodine in urine samples were detected.


RESULTS
The medians of urinary iodine were 231.49, 158.25 and 328.35 microg/L for women in early, middle and late period of pregnancy, The ratio of urinary iodine below 150 microg/L were 39.29%, 45.16% and 25.81%, respectively. The FT3, FT4 levels in the first trimester were higher than those in the third trimester (P < 0.05) and TSH level was increased, but no significant difference (P > 0.05). The positive rate of TGAb and TMAb antibody of pregnant women in different period of time were not significantly different (P > 0.05). The incidence of thyroid function disorder was significantly different in different gestation periods.


CONCLUSIONS
Generally, the iodine nutritional status of these pregnant women was appropriate, but there was a tendency towards hypothyroid in some women. Monitoring urinary iodine and thyroid function in pregnant women should be carried out regularly.
Gansu Centre for Disease of Control and Prevention,Lanzhou 730020, China. lihb2010@126.com
Hongbo
H
Li
Yanling
Y
Wang
Jing
J
Zheng
Yancai
Y
Wang
Dahong
D
Huang
Liping
L
Liang
Xudong
X
Ren
Yugui
Y
Dou
Xiaonan
X
Zhu
D001323:Autoantibodies; D003430:Cross-Sectional Studies; D019587:Dietary Supplements; D005260:Female; D006801:Humans; D007037:Hypothyroidism; D007454:Iodides; D007455:Iodine / Q000378:metabolism*; D009752:Nutritional Status; D011247:Pregnancy / Q000502:physiology*; D011248:Pregnancy Complications; D011261:Pregnancy Trimester, First; D011263:Pregnancy Trimester, Third; D013960:Thyroid Function Tests; D013963:Thyroid Hormones / Q000378:metabolism; D013972:Thyrotropin; D013974:Thyroxine / Q000378:metabolism; D014284:Triiodothyronine
D001323:Autoantibodies; D007454:Iodides; D013963:Thyroid Hormones; C006606:anti-thyroglobulin; C056626:thyroid microsomal antibodies; D014284:Triiodothyronine; D013972:Thyrotropin; D007455:Iodine; D013974:Thyroxine