Association between the IVS4G>T mutation in the TCF7L2 gene and susceptibility to diabetes in cystic fibrosis patients.
BACKGROUND
Clinical complications appear to be a decisive factor for the prognosis of patients. Diabetes is an important complication of cystic fibrosis(CF). In our study we evaluated the association between the IVS4G>T mutation in the TCF7L2 gene with the presence of diabetes in patients with CF.


RESULTS
We evaluated 145 patients with CF in relation to the genotype of the IVS4G>T mutation. For this, the PCR method associated with specific enzyme digestion was used. The genotypes G/G, G/T and T/T were observed to have frequencies of 54 (37.2%), 78 (53.8%) and 13 (9%), respectively. There was no association between genotype and the occurrence of diabetes among patients.


CONCLUSIONS
In our sample, no association was found between the IVS4G>T mutation in the TCF7L2 gene and diabetes.
Department of Medical Genetics, Faculty of Medical Sciences, University of Campinas (UNICAMP), Campinas, SP, Brazil.
Daniela Tenório
DT
Furgeri
Fernando Augusto de Lima
FA
Marson
Antonio Fernando
AF
Ribeiro
Carmen Silvia
CS
Bertuzzo
D001938:Brazil / Q000453:epidemiology; D002648:Child; D015897:Comorbidity; D003550:Cystic Fibrosis / Q000453:epidemiology / Q000235:genetics*; D019005:Cystic Fibrosis Transmembrane Conductance Regulator / Q000235:genetics*; D003920:Diabetes Mellitus / Q000453:epidemiology / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease / Q000235:genetics; D005838:Genotype; D006801:Humans; D008297:Male; D009154:Mutation; D020641:Polymorphism, Single Nucleotide; D058118:Transcription Factor 7-Like 2 Protein / Q000235:genetics*
C544894:TCF7L2 protein, human; D058118:Transcription Factor 7-Like 2 Protein; D019005:Cystic Fibrosis Transmembrane Conductance Regulator