Acute stroke after intravitreal bevacizumab to treat choroidal neovascularization due to angioid streaks in pseudoxanthoma elasticum : a severe systemic adverse event after an off-label procedure.
To report the occurrence of acute stroke after intravitreal bevacizumab administration to treat choroidal neovascularization due to angioid streaks in a patient affected by pseudoxanthoma elasticum. A 54-year-old man with pseudoxanthoma elasticum had vision loss because of choroidal neovascularization due to angioid streaks. He underwent two intravitreal bevacizumab injections. Three days after the second procedure the patient was afflicted by acute stroke. Intravitreal injection of bevacizumab to treat choroidal neovascularization due to angioid streaks in pseudoxanthoma elasticum could lead to severe systemic adverse events.
Anthea Hospital, GVM Care and Research, Via Camillo Rosalba, 35, 70125, Bari, Italy. gianlucabesozzi@gmail.com
Gianluca
G
Besozzi
Andrea
A
Ferrara
Enrico
E
Epifani
Daniela
D
Intini
Margherita
M
Apruzzese
Antonio
A
Provenzano
Michele
M
Vetrugno
D000208:Acute Disease; D020533:Angiogenesis Inhibitors / Q000008:administration & dosage / Q000009:adverse effects; D000793:Angioid Streaks / Q000188:drug therapy* / Q000209:etiology; D061067:Antibodies, Monoclonal, Humanized / Q000008:administration & dosage / Q000009:adverse effects*; D000068258:Bevacizumab; D020256:Choroidal Neovascularization / Q000188:drug therapy* / Q000209:etiology; D006801:Humans; D058449:Intravitreal Injections; D008297:Male; D008875:Middle Aged; D056687:Off-Label Use; D011561:Pseudoxanthoma Elasticum / Q000150:complications*; D012720:Severity of Illness Index; D020521:Stroke / Q000139:chemically induced*
D020533:Angiogenesis Inhibitors; D061067:Antibodies, Monoclonal, Humanized; D000068258:Bevacizumab