Alleviation of a severe pruritic flare-up in a 13-year-old child with chronic atopic dermatitis treated with methylprednisolone aceponate 0.1%.
A 13-year-old girl with a 12-year history of atopic dermatitis (AD), testing positive for inhalation and foodborne allergens, presented with season-dependent, highly pruritic AD lesions and lichenification on her cheeks, trunk, forearms, and ankle joints. After immediate treatment with oral antihistamine, followed by once-daily methylprednisolone aceponate (MPA) 0.1% (Advantan(®)) cream for the facial lesions and Advantan ointment for treatment of the trunk and extremities for 7 days, marked improvement of AD signs (e.g., redness and lichenification) was noted. Pruritus was completely alleviated. No side effects were reported for Advantan. By combining multiple formulations of Advantan, treatment was tailored to successfully treat a widespread flare in this adolescent patient with chronic AD.
Russian National Research Medical University, Department of Skin Diseases & Cosmetology, Leninsky Prospect 17, Moscow, Russia. clinderm11@gmail.com
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D000287:Administration, Topical; D000293:Adolescent; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D002908:Chronic Disease; D003876:Dermatitis, Atopic / Q000188:drug therapy* / Q000503:physiopathology; D005260:Female; D006801:Humans; D008775:Methylprednisolone / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000627:therapeutic use; D011537:Pruritus / Q000188:drug therapy* / Q000503:physiopathology
D000893:Anti-Inflammatory Agents; C078007:methylprednisolone aceponate; D008775:Methylprednisolone