The levels of β-thromboglobulin in female rheumatoid arthritis patients as activation criteria.
The activation of the platelets plays a key role in the formation of thrombosis. The variables such as mean platelet volume, platelet factor 4 and β-thromboglobulin have been used in the demonstration of the platelet activation. However, when the literature was reviewed, there was not found any study investigating the level of β-thromboglobulin in patients with rheumatoid arthritis. Our goal is to evaluate the β-thromboglobulin levels together with mean platelet volume in patients with arthritis. This study is a clinical study which has a control group that has been designed prospectively, and in this study, Rheumatology Outpatient Clinic follow-up patients with rheumatoid arthritis and healthy control group were studied. All patients and healthy volunteers were examined β-thromboglobulin and mean platelet volume. Twenty-two patients with rheumatoid arthritis and 21 healthy volunteers participated in the study. β-Thromboglobulin mean was found as 98.00 ± 60.49 ng/mL in rheumatoid arthritis group and it was 62.38 ± 30.41 ng/mL in healthy control group. The differences between these groups were significant in terms of the levels of β-thromboglobulin (p = 0.02). We found significant differences between the groups in terms of mean platelet volume (p = 0.049). In this study, the level of β-thromboglobulin was found significantly higher in patients with rheumatoid arthritis, which is a chronic inflammatory disease. This result could be an indicator, such as platelet activation in patients with rheumatoid arthritis, or it may be a helper marker in the follow-up and treatment of developing cardiovascular risk.
Faculty of Medicine, Internal Medicine Clinic, Bezmialem Vakif University, 34093 Fatih, Istanbul, Turkey. ckaratoprak@hotmail.com
Cumali
C
Karatoprak
Seyit
S
Uyar
Gul Babacan
GB
Abanonu
Seval Masatlioglu
SM
Pehlevan
Nalan
N
Okuroglu
Refik
R
Demirtunc
D000293:Adolescent; D000328:Adult; D001172:Arthritis, Rheumatoid / Q000097:blood*; D015415:Biomarkers / Q000097:blood; D016022:Case-Control Studies; D016009:Chi-Square Distribution; D005260:Female; D006801:Humans; D008055:Lipids / Q000097:blood; D008875:Middle Aged; D015539:Platelet Activation; D010976:Platelet Count; D011237:Predictive Value of Tests; D011379:Prognosis; D011446:Prospective Studies; D015854:Up-Regulation; D055815:Young Adult; D001620:beta-Thromboglobulin / Q000032:analysis*
D015415:Biomarkers; D008055:Lipids; C061615:PPBP protein, human; D001620:beta-Thromboglobulin