Common variants in the ATP2B1 gene are associated with hypertension and arterial stiffness in Chinese population.
Genome-wide association studies have identified the ATP2B1 gene associated with blood pressure (BP), the evidence from large scale Chinese population was still rare. We performed the current replication study to test the association of the ATP2B1 gene and hypertension and BP in two unrelated Chinese cohorts including 2,831 unrelated individuals with hypertension and 1,987 controls in total. We also examined the influences of the ATP2B1 gene on the arterial stiffness through evaluation of carotid-femoral pulse wave velocities (cf-PWV) in 164 untreated hypertensives. The major findings of this study were that four loci--rs10858911, rs2681472, rs17249754 and rs1401982--associated with any or all of four traits: hypertension (P = 0.001-4.6E-05; odds ratio, 0.83-0.87), systolic BP (P = 0.003-0.004), diastolic BP (P = 0.002-0.003) and cf-PWV (P = 0.002-0.004). All the comparisons were adjusted for sex, age, age(2) and body mass index. We validated the association of the ATP2B1 gene and susceptibility to hypertension, BP traits and cf-PWV in Chinese population. In addition, further genetic and functional research was warranted to elucidate the concrete locus in the ATP2B1 gene that influenced the manifestation of BP and vascular function.
State Key Laboratory of Medical Genomics, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.
Yan
Y
Wang
Yi
Y
Zhang
Yan
Y
Li
Xueya
X
Zhou
Xiaofeng
X
Wang
Pingjin
P
Gao
Li
L
Jin
Xuegong
X
Zhang
Dingliang
D
Zhu
D000328:Adult; D000368:Aged; D002339:Carotid Arteries / Q000503:physiopathology; D016022:Case-Control Studies; D002681:China; D005260:Female; D005263:Femoral Artery / Q000503:physiopathology; D005787:Gene Frequency; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006801:Humans; D006973:Hypertension / Q000235:genetics* / Q000503:physiopathology; D015810:Linkage Disequilibrium; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D053499:Plasma Membrane Calcium-Transporting ATPases / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D063177:Pulse Wave Analysis; D059289:Vascular Stiffness / Q000235:genetics*
C506952:ATP2B1 protein, human; D053499:Plasma Membrane Calcium-Transporting ATPases