Hyperactivation balances sensory processing deficits during mood induction in schizophrenia.
While impairments in emotion recognition are consistently reported in schizophrenia, there is some debate on the experience of emotion. Only few studies investigated neural correlates of emotional experience in schizophrenia. The present functional magnetic resonance imaging study compared a standard visual mood induction paradigm with an audiovisual method aimed at eliciting emotions more automatically. To investigate the interplay of sensory, cognitive and emotional mechanisms during emotion experience, we examined connectivity patterns between brain areas. Sixteen schizophrenia patients and sixteen healthy subjects participated in two different mood inductions (visual and audiovisual) that were administered for different emotions (happiness, sadness and neutral). Confirming the dissociation of behavioral and neural correlates of emotion experience, patients rated their mood similarly to healthy subjects but showed differences in neural activations. Sensory brain areas were activated less, increased activity emerged in higher cortical areas, particularly during audiovisual stimulation. Connectivity was increased between primary and secondary sensory processing areas in schizophrenia. These findings support the hypothesis of a deficit in filtering and processing sensory information alongside increased higher-order cognitive effort compensating for perception deficits in the affective domain. This may suffice to recover emotion experience in ratings of clinically stable patients but may fail during acute psychosis.
Department of Psychiatry, Psychotherapy and Psychosomatics, RWTH Aachen University, Pauwelsstr. 30, 52074 Aachen, Germany. miriam.dyck@rwth-aachen.de.
Miriam
M
Dyck
James
J
Loughead
Ruben C
RC
Gur
Frank
F
Schneider
Klaus
K
Mathiak
D000161:Acoustic Stimulation; D000328:Adult; D000339:Affect / Q000502:physiology*; D001307:Auditory Perception / Q000502:physiology*; D001921:Brain / Q000503:physiopathology*; D001931:Brain Mapping; D005149:Facial Expression; D005260:Female; D006240:Happiness; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D009146:Music; D009434:Neural Pathways / Q000502:physiology; D009483:Neuropsychological Tests; D010775:Photic Stimulation; D012559:Schizophrenia / Q000503:physiopathology*; D012565:Schizophrenic Psychology; D014796:Visual Perception / Q000502:physiology*