Diabetes mellitus is associated with the presence of metastatic spread at disease presentation in hepatocellular carcinoma.
OBJECTIVE
Diabetes mellitus (DM) is identified as a negative prognostic indicator in hepatocellular carcinoma (HCC).


METHODS
A retrospective review of HCC patients was conducted to assess the effect of DM on clinical variables.


RESULTS
Ninety-seven of 265 (34%) patients had DM at the time of diagnosis. Distant metastasis was found in 33% (30/91) of patients with DM compared with only 9.7% (17/174) of those without DM (OR: 4.5, 95% CI: 2.3-8.8, p < .0001). This difference remained significant when adjusting for other clinical variables (OR: 10.0, 95% CI: 3.9-25.7, p < .0001).


CONCLUSIONS
DM is associated with the presence of metastatic disease among a single institution cohort of HCC patients.
James P. Wilmot Cancer Center and Department of Medicine, University of Rochester, Rochester, New York 14642, USA. gregory connolly@urmc.rochester.edu
Gregory C
GC
Connolly
Saman
S
Safadjou
Rui
R
Chen
Afamefuna
A
Nduaguba
Richard
R
Dunne
Alok A
AA
Khorana
Aram F
AF
Hezel
D000368:Aged; D006528:Carcinoma, Hepatocellular / Q000150:complications* / Q000401:mortality / Q000473:pathology*; D003920:Diabetes Mellitus; D005260:Female; D006801:Humans; D053208:Kaplan-Meier Estimate; D008113:Liver Neoplasms / Q000150:complications* / Q000401:mortality / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D009362:Neoplasm Metastasis / Q000473:pathology; D009367:Neoplasm Staging; D011379:Prognosis; D016016:Proportional Hazards Models; D012189:Retrospective Studies