From basic biology to randomized clinical trial: the Beta Radiation for Arteriovenous Graft Outflow Stenosis (BRAVO II).
The BRAVO-II study was a randomized controlled study of endovascular radiation therapy as compared to sham radiation therapy, following angioplasty of a thrombosed PRFE graft. The results did not show a benefit of endovascular radiation therapy, albeit in the context of an early termination of the study at less than 50% enrollment due to business reasons. Emphasis is laid on the fact that there may still be a role for radiation therapy in specific clinical settings associated with dialysis vascular access dysfunction.
Dialysis Vascular Research Group, Division of Nephrology, University of Cincinnati and VA Medical Center, Cincinnati, Ohio, USA. prabir.roychaudhury@uc.edu
Prabir
P
Roy-Chaudhury
Perry
P
Arnold
Jeff
J
Seigel
Sanjay
S
Misra
D017130:Angioplasty; D001166:Arteriovenous Shunt, Surgical; D001610:Beta Particles; D001918:Brachytherapy / Q000379:methods*; D004311:Double-Blind Method; D005260:Female; D006083:Graft Occlusion, Vascular / Q000532:radiotherapy*; D006801:Humans; D008297:Male; D008875:Middle Aged; D015337:Multicenter Studies as Topic; D010919:Placebos; D016032:Randomized Controlled Trials as Topic; D006435:Renal Dialysis; D016896:Treatment Outcome; D014654:Vascular Patency
D010919:Placebos