Uterine endometrial carcinoma: 10 years' experience with long-term follow-up at a single Korean institution.
OBJECTIVE
To evaluate prognostic factors in Korean patients with endometrial cancer.


METHODS
A retrospective analysis was conducted on 248 patients who were staged surgically at the Samsung Medical Center between 1995 and 2004. Survival data were analyzed using Kaplan-Meier estimates, and multivariate analysis was performed using the Cox regression method.


RESULTS
The median age was 51 years (range 21-75), which was younger than in previous studies in Western patients, and the age of 50 years was the cutoff to predict survival. More than half (55.6%) were normal weight or underweight (BMI <25). Multivariate analysis revealed that age, Fédération Internationale de Gynécologie et d'Obstétrique (FIGO) stage, and histopathology were independent predictors of disease-free survival, and FIGO stage and p53 mutation were independent prognostic factors for disease-specific survival (DSS). The 5-year DSS for patients with stage I, II, III and IV disease was 95.6, 93.8, 69.8 and 50%, respectively. The 5-year DSS rate for patients with a p53 mutation was 84.4%, compared with 97.1% for patients without.


CONCLUSIONS
Korean patients with endometrial cancer were younger and had a lower BMI than previously reported. Furthermore, age greater than 50 years was predictive of a poor outcome. Age, FIGO stage, histopathology and a p53 mutation were independent prognostic factors for survival.
Department of Obstetrics and Gynecology, at Chung-Ang University School of Medicine, Seoul, Korea.
Eun-Ju
EJ
Lee
Tae-Joong
TJ
Kim
Chel Hun
CH
Choi
Jeong-Won
JW
Lee
Je-Ho
JH
Lee
Duk-Soo
DS
Bae
Hyoung Moo
HM
Park
Byoung-Gie
BG
Kim
D000328:Adult; D000368:Aged; D018394:CA-125 Antigen / Q000097:blood; D018269:Carcinoma, Endometrioid / Q000235:genetics* / Q000556:secondary* / Q000601:surgery; D018572:Disease-Free Survival; D016889:Endometrial Neoplasms / Q000235:genetics* / Q000473:pathology* / Q000601:surgery; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D053208:Kaplan-Meier Estimate; D008207:Lymphatic Metastasis; D008565:Membrane Proteins / Q000097:blood; D008875:Middle Aged; D015999:Multivariate Analysis; D009154:Mutation; D009361:Neoplasm Invasiveness; D009367:Neoplasm Staging; D016016:Proportional Hazards Models; D011960:Receptors, Estrogen / Q000378:metabolism; D011980:Receptors, Progesterone / Q000378:metabolism; D056910:Republic of Korea; D012189:Retrospective Studies; D015996:Survival Rate; D013997:Time Factors; D016159:Tumor Suppressor Protein p53 / Q000235:genetics*; D055815:Young Adult
D018394:CA-125 Antigen; C451759:MUC16 protein, human; D008565:Membrane Proteins; D011960:Receptors, Estrogen; D011980:Receptors, Progesterone; D016159:Tumor Suppressor Protein p53