Safety and efficacy of buprenorphine for analgesia in laboratory mice and rats.
Buprenorphine is a long-acting opiate with a high therapeutic index. The authors review the pharmacology, toxicity, analgesic effects and delivery of buprenorphine for use in laboratory mice and rats. Buprenorphine-based analgesic therapy has a substantial record of safety, and there is growing evidence of its effectiveness for treating post-operative pain. Nonetheless, more research is needed to determine optimal delivery systems and analgesic regimens for pain therapy in laboratory animals.
Johns Hopkins School of Medicine, Baltimore, MD, USA. mguarieri@comcast.net
Michael
M
Guarnieri
Cory
C
Brayton
Louis
L
DeTolla
Nadine
N
Forbes-McBean
Rachel
R
Sarabia-Estrada
Patricia
P
Zadnik
D000698:Analgesia / Q000295:instrumentation / Q000379:methods / Q000662:veterinary*; D000701:Analgesics, Opioid / Q000494:pharmacology* / Q000627:therapeutic use / Q000633:toxicity*; D000818:Animals; D002047:Buprenorphine / Q000494:pharmacology* / Q000627:therapeutic use / Q000633:toxicity*; D051379:Mice; D010149:Postoperative Pain / Q000188:drug therapy / Q000662:veterinary*; D051381:Rats
D000701:Analgesics, Opioid; D002047:Buprenorphine