Synthesis of 3-aryl-1,2,4-benzotriazines via intramolecular cyclization of solid-supported o-hydrazidoanilines.
An efficient solid-phase protocol for the rapid generation of libraries of biologically promising 1,2,4-benzotriazines, including amino acid-derived components, is described.
Grupo de Investigación de Compuestos Heterocíclicos, Departamento de Química, Universidad del Valle, Cali, AA 25360, Colombia.
Edwar
E
Cortés
Luciana
L
Méndez
Ernesto G
EG
Mata
Rodrigo
R
Abonia
Jairo
J
Quiroga
Braulio
B
Insuasty
D000814:Aniline Compounds / Q000737:chemistry*; D003500:Cyclization; D006834:Hydrazines / Q000737:chemistry*; D015394:Molecular Structure; D060327:Solid-Phase Synthesis Techniques / Q000379:methods*; D014227:Triazines / Q000138:chemical synthesis*
D000814:Aniline Compounds; D006834:Hydrazines; D014227:Triazines; C029424:hydrazine