Synthetic bicyclic iminosugar derivatives fused thiazolidin-4-one as new potential HIV-RT inhibitors.
Novel bicyclic iminosugar derivatives fused thiazolidin-4-one were conveniently synthesized by double Pummerer rearrangements, and their HIV reverse transcriptase (RT) inhibitory activities were preliminary examined. The notable anti-HIV-RT activity demonstrated that such bicyclic azasugars hold potential as a new kind of HIV-RT inhibitors.
Key Laboratory of Chemical Biology of Hebei Province, College of Chemistry and Environmental Science, Hebei University, Baoding 071002, China. hua-todd@163.com
Hua
H
Chen
Tianyu
T
Yang
Sinan
S
Wei
Hongzhi
H
Zhang
Rui
R
Li
Zhanbin
Z
Qin
Xiaoliu
X
Li
D018360:Crystallography, X-Ray; D054303:HIV Reverse Transcriptase / Q000037:antagonists & inhibitors* / Q000378:metabolism; D015497:HIV-1 / Q000201:enzymology; D006801:Humans; D050111:Imino Sugars / Q000138:chemical synthesis / Q000737:chemistry*; D008968:Molecular Conformation; D011485:Protein Binding; D018894:Reverse Transcriptase Inhibitors / Q000138:chemical synthesis* / Q000737:chemistry / Q000378:metabolism; D013696:Temperature; D013844:Thiazoles / Q000737:chemistry*; D013997:Time Factors
D050111:Imino Sugars; D018894:Reverse Transcriptase Inhibitors; D013844:Thiazoles; D054303:HIV Reverse Transcriptase