Increased risk of hepatitis E virus infection in schizophrenia.
Until now, the risk of HEV infection in schizophrenia was unknown. The present results showed that the seroprevalence of anti-HEV IgG and anti-HEV IgM in schizophrenia were significantly higher than that in healthy controls. Anti-HEV IgG positivity increased with age and with the duration of disease in schizophrenia patients. Moreover, schizophrenia patients with increased CD4(+)/CD8(+) T-cell ratios (>2.03) had higher anti-HEV IgG detection rates than those with normal ratios (1.05-2.03). Compared with the schizophrenia patients who tested anti-HEV IgG negative, the levels of interleukin-4 and interleukin-10 (Th2 cytokines) were significantly higher, while the interleukin-12 (Th1 cytokine) level was significantly lower, in those with anti-HEV IgG positivity. Of five schizophrenia patients who were anti-HEV IgM positive, four had elevated CD4(+)/CD8(+) T-cell ratios. HEV RNA was isolated from one of these four patients and classified as genotype 4. Anti-HEV IgM positivity was not detected among healthy controls. Therefore, schizophrenia patients exhibited a higher risk of HEV infection than controls.
Huaian Third Hospital, 282 Huaihai West Road, Huaian, 223001, People's Republic of China.
Yong
Y
Xue
Xiaohua
X
Sun
Yinghui
Y
Li
Xin
X
Liu
Chen
C
Dong
D000293:Adolescent; D000328:Adult; D000368:Aged; D016516:CD4-CD8 Ratio; D016207:Cytokines / Q000097:blood; D005260:Female; D005838:Genotype; D006508:Hepatitis Antibodies / Q000097:blood*; D018963:Hepatitis Antigens / Q000097:blood*; D016751:Hepatitis E / Q000453:epidemiology*; D016752:Hepatitis E virus / Q000276:immunology*; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood; D007075:Immunoglobulin M / Q000097:blood; D008297:Male; D008875:Middle Aged; D012367:RNA, Viral / Q000097:blood / Q000235:genetics / Q000302:isolation & purification; D018570:Risk Assessment; D012559:Schizophrenia / Q000150:complications*; D016036:Seroepidemiologic Studies; D055815:Young Adult
D016207:Cytokines; D006508:Hepatitis Antibodies; D018963:Hepatitis Antigens; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D012367:RNA, Viral