Diversity of Bipolaris species in clinical samples in the United States and their antifungal susceptibility profiles.
A set of 104 isolates from human clinical samples from the United States, morphologically compatible with Bipolaris, were morphologically and molecularly identified through the sequence analysis of the internal transcribed space (ITS) region of the nuclear ribosomal DNA (rDNA). The predominant species was Bipolaris spicifera (67.3%), followed by B. hawaiiensis (18.2%), B. cynodontis (8.6%), B. micropus (2.9%), B. australiensis (2%), and B. setariae (1%). Bipolaris cynodontis, B. micropus, and B. setariae represent new records from clinical samples. The most common anatomical sites where isolates were recovered were the nasal region (30.7%), skin (19.2%), lungs (14.4%), and eyes (12.5%). The antifungal susceptibilities of 5 species of Bipolaris to 9 drugs are provided. With the exception of fluconazole and flucytosine, the antifungals tested showed good activity.
Mycology Unit, Medical School and IISPV, Universitat Rovira i Virgili, Reus, Spain.
K C
KC
da Cunha
D A
DA
Sutton
A W
AW
Fothergill
J
J
Cano
J
J
Gené
H
H
Madrid
S
S
De Hoog
P W
PW
Crous
J
J
Guarro
D000935:Antifungal Agents / Q000494:pharmacology*; D001203:Ascomycota / Q000145:classification / Q000187:drug effects* / Q000235:genetics / Q000302:isolation & purification*; D016000:Cluster Analysis; D004271:DNA, Fungal / Q000737:chemistry / Q000235:genetics; D021903:DNA, Ribosomal Spacer / Q000737:chemistry / Q000235:genetics; D014644:Genetic Variation; D006801:Humans; D008826:Microbial Sensitivity Tests; D008969:Molecular Sequence Data; D009181:Mycoses / Q000382:microbiology*; D017422:Sequence Analysis, DNA; D014481:United States
D000935:Antifungal Agents; D004271:DNA, Fungal; D021903:DNA, Ribosomal Spacer