Sister chromatids segregate at mitosis without mother-daughter bias in Saccharomyces cerevisiae.
There is evidence accumulating for nonrandom segregation of one or more chromosomes during mitosis in different cell types. We use cell synchrony and two methods to show that all chromatids of budding yeast segregate randomly and that there is no mother-daughter bias with respect to Watson and Crick-containing strands of DNA.
Department of Biochemistry and Molecular Genetics, University of Virginia School of Medicine, University of Virginia, Charlottesville, VA 22906, USA.
Brice E
BE
Keyes
Kenneth D
KD
Sykes
Courtney E
CE
Remington
Daniel J
DJ
Burke
D002842:Chromatids / Q000378:metabolism; D020090:Chromosome Segregation; D015825:Chromosomes, Fungal; D008938:Mitosis; D012441:Saccharomyces cerevisiae / Q000235:genetics*