Bioactive sesquiterpenoids and diterpenoids from the liverwort Bazzania albifolia.
One undescribed 6,7-secofusicoccane-type diterpene, albifolione (1), and one new aromadendrane-type sesquiterpenoid ketone, methyl 2-oxoaromadendra-1(10),3-dien-12-oate (2), along with four known compounds, δ-cuparenol (3), fusicoauritone (4), chiloscyphenols A and B (5 and 6, resp.), were isolated from the liverwort Bazzania albifolia Horik. The structures and relative configurations of 1 and 2 were established unequivocally on the basis of spectroscopic data analysis. Preliminary bioassay revealed that compound 5 showed quite strong cytotoxicity against the human tumor cell line MCF-7, with an IC(50) value of 5.6 μM.
Department of Natural Products Chemistry, School of Pharmaceutical Sciences, Shandong University, No. 44 West Wenhua Road, Jinan 250012, PR China.
Na
N
Liu
Dong-Xiao
DX
Guo
Shu-Qi
SQ
Wang
Yan-Yan
YY
Wang
Li
L
Zhang
Gang
G
Li
Hong-Xiang
HX
Lou
D002470:Cell Survival / Q000187:drug effects; D004224:Diterpenes / Q000737:chemistry* / Q000302:isolation & purification / Q000633:toxicity; D035926:Hepatophyta / Q000737:chemistry*; D006801:Humans; D061986:MCF-7 Cells; D009682:Magnetic Resonance Spectroscopy; D008968:Molecular Conformation; D012717:Sesquiterpenes / Q000737:chemistry* / Q000302:isolation & purification / Q000633:toxicity
D004224:Diterpenes; D012717:Sesquiterpenes; C578896:albifolione; C578897:methyl 2-oxoaromadendra-1(10),3-dien-12-oate