Caught in the act: reprogramming of adipocytes into lymph-node stroma.
Interactions between stromal organizer cells and hematopoietic lymphoid inducer cells initiate lymph-node formation. In this issue of Immunity, Bénézech et al. demonstrate that adipocyte precursors give rise to lymph-node stromal organizer cells, illuminating an important step in lymphoid-tissue development.
Department of Developmental Immunology, Max Planck Institute of Immunobiology and Epigenetics, Freiburg, Germany. boehm@immunbio.mpg.de
Thomas
T
Boehm