Decrease of cerebral mast cell degranulation after systemic administration of lipopolysaccharide.
BACKGROUND
The mast cell is an immunocyte, but its functions in the brain remain unclear.


METHODS
In a rat model of weak inflammation, we analyzed the effect of a gram-negative bacterial lipopolysaccharide injection (100 μg/kg) on thalamic mast cell (MC) population.


CONCLUSIONS
We demonstrate a significant decrease of their degranulation, which suggests the implication of MC in preventing sepsis on the brain.
Laboratory of Neurophysics and Physiology, CNRS UMR 8119, Paris Descartes University, 45 Rue Des Saints Pères, 75270 Paris, France.
David
D
Dubayle
Anne
A
Héron
D000818:Animals; D015550:Cell Degranulation / Q000187:drug effects* / Q000502:physiology; D004195:Disease Models, Animal; D004660:Encephalitis / Q000139:chemically induced / Q000276:immunology*; D008070:Lipopolysaccharides / Q000494:pharmacology*; D008297:Male; D008407:Mast Cells / Q000187:drug effects* / Q000502:physiology; D051381:Rats; D017208:Rats, Wistar; D013788:Thalamus / Q000187:drug effects* / Q000502:physiology
D008070:Lipopolysaccharides