Serum adiponectin and fetuin-A levels in children with nephrotic syndrome.
Nephrotic syndrome is associated with an increased risk of atherosclerosis and endothelial dysfunction. The aim of this work was to evaluate serum adiponectin and fetuin-A levels in children with idiopathic nephrotic syndrome. The study was carried out on 70 children, divided into 2 groups. Group I included 35 children with steroid responsive idiopathic nephrotic syndrome (15 in relapse and 20 in remission) and group II included 35 apparently healthy children served as control with matched age and sex. The results showed significantly higher adiponectin with significantly lower fetuin-A in patients than controls and in relapse group as compared to both remission and control groups. There was a significant negative correlation between adiponectin and fetuin-A.


CONCLUSIONS
Both adiponectin and fetuin-A may be useful markers of activity of nephrotic syndrome. Increased serum adiponectin levels in relapse compared to remission might be the reflection of a compensatory response to nephrotic state characterized by massive proteinuria, hypoalbuminemia and hyperlipidemia. Low concentration of fetuin-A in relapsed children of NS may depend on proteinuria.
Department of Pediatrics, Faculty of Medicine, Menoufia, University, Egypt.
Ghada M
GM
El-Mashad
Salwa M
SM
Essa
D052242:Adiponectin / Q000097:blood*; D015415:Biomarkers / Q000097:blood; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D008297:Male; D009404:Nephrotic Syndrome / Q000097:blood*; D018709:Statistics, Nonparametric; D060749:alpha-2-HS-Glycoprotein / Q000378:metabolism*
C556354:AHSG protein, human; D052242:Adiponectin; D015415:Biomarkers; D060749:alpha-2-HS-Glycoprotein