Effect of guided bone regeneration with or without pericardium bioabsorbable membrane on bone formation.
OBJECTIVE
The purpose of this study was to evaluate bone formation after using allogeneic bone alone or with a membrane.


METHODS
Bone graft was performed using the allograft Tutoplast, mineralized cancellous bone allograft, and pericardium in calvarial defects of 60 rats. Rats were divided in 3 groups: control group (no bone graft), group 1 (bone graft without membrane), and group 2 (bone graft with membrane).


RESULTS
The most new bone formation occurred in group 2. After 6 weeks, group 2 showed infiltration of inflammatory cells, and inflammatory cells were still observed after 12 weeks. The membrane remained even after 12 weeks, and the membrane facilitated bone regeneration by blocking connective tissue.


CONCLUSIONS
The membrane facilitated new bone formation by inhibiting connective tissue invasion.
Graduate Student, Department of Oral and Maxillofacial Surgery, School of Dentistry, Chosun University, GwangJu City, South Korea.
Yoo-Seok
YS
Ahn
Su-Gwan
SG
Kim
Chun-Sung
CS
Kim
Ji-Su
JS
Oh
Sung-Chul
SC
Lim
D020341:Absorbable Implants; D000704:Analysis of Variance; D000818:Animals; D001672:Biocompatible Materials; D001861:Bone Regeneration / Q000502:physiology*; D016025:Bone Transplantation / Q000379:methods* / Q000473:pathology; D048091:Guided Tissue Regeneration / Q000379:methods*; D008297:Male; D008567:Membranes, Artificial; D051381:Rats; D017207:Rats, Sprague-Dawley; D012886:Skull / Q000601:surgery; D014184:Transplantation, Homologous / Q000379:methods
D001672:Biocompatible Materials; D008567:Membranes, Artificial