Antioxidative and DNA protective effects of bacillomycin D-like lipopeptides produced by b38 strain.
In the present study, we evaluated the antioxidant and the scavenging ability of C14, C15 and C16 bacillomycin D-like lipopeptides produced by B38 strain. They all displayed strong reducing power activity, hydroxyl and superoxide anion radicals scavenging activities and inhibition of lipid peroxidation. In addition, they were found to protect plasmid DNA damage from hydroxyl radical oxidation. Data suggested that their antioxidant potency can be attributed to the hydrophobic and aromatic side-chain groups of their amino acids as well as to the aliphatic chain of their beta amino fatty acids. Note that the hydrocarbon chain length did not interfere with the antioxidant power. Overall, such bacillomycin D lipopeptides which exhibit antioxidant and radical scavenging activities may be useful for cosmetic, therapeutic or pharmaceutical purposes in order to delay or prevent oxidative deterioration of manufactured products.
Laboratoire des Substances Bioactives, Centre de Biotechnologie de Borj-Cedria, BP-901, 2050, Hammam-lif cedex, Tunisia.
Olfa
O
Tabbene
Dorra
D
Gharbi
Imen Ben
IB
Slimene
Salem
S
Elkahoui
Mohamed Najib
MN
Alfeddy
Pascal
P
Cosette
Maria Luisa
ML
Mangoni
Thierry
T
Jouenne
Ferid
F
Limam
D023181:Antimicrobial Cationic Peptides; D003470:Culture Media / Q000737:chemistry; D004247:DNA / Q000235:genetics*; D004249:DNA Damage; D016166:Free Radical Scavengers / Q000737:chemistry* / Q000302:isolation & purification / Q000378:metabolism / Q000494:pharmacology*; D005609:Free Radicals / Q000737:chemistry / Q000494:pharmacology; D007501:Iron / Q000737:chemistry; D015227:Lipid Peroxidation / Q000187:drug effects; D055666:Lipopeptides / Q000096:biosynthesis / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D018384:Oxidative Stress / Q000187:drug effects; D010455:Peptides / Q000737:chemistry*; D017382:Reactive Oxygen Species / Q000378:metabolism
D023181:Antimicrobial Cationic Peptides; D003470:Culture Media; D016166:Free Radical Scavengers; D005609:Free Radicals; D055666:Lipopeptides; D010455:Peptides; D017382:Reactive Oxygen Species; C027845:bacillomycin D; D004247:DNA; D007501:Iron