Melatonin and cortisol rhythm in patients with extensive nasal polyposis.
OBJECTIVE
Extensive nasal polyposis is an inflammatory disease which effects 1%-4% of normal population. The mechanism of its formation and the circadian rhythm of cortisol and melatonin in ENP have not investigated.


METHODS
Salivary levels of melatonin and cortisol were measured by radioimmunoassay in 31 patients with extensive nasal polyposis and in 27 control subjects matched for age and gender. In both groups none of the subjects did not have obstructive sleep apnea.


RESULTS
The baseline and the peak levels of salivary melatonin in the extensive nasal polyposis group were significantly lower than in the control group (p<0.001). However, no differences were found in the acrophase and the peak duration of salivary melatonin between the study and control groups (p>0.05). The highest values of melatonin were recorded at 04:00 h in both the study and control groups. The amplitude and the 24 h mean levels of salivary cortisol in the extensive nasal polyposis group were significantly lower than in the control group (p<0.001). The acrophase was delayed by about 8 h in extensive nasal polyposis patients (p<0.001).


CONCLUSIONS
The circadian rhythms of salivary melatonin and cortisol were found to be disrupted in patients with extensive nasal polyposis. These results may be applicable as therapeutic tools in the future and melatonin drugs might be useful in the therapy of nasal polyposis like cortisol drugs.
Erzurum Education and Research Hospital, Otorhinolaryngology Dept, Erzurum, Turkey. vuralf@mynet.com
Vural
V
Fidan
Hamit Hakan
HH
Alp
Sadettin
S
Kalkandelen
Cemal
C
Cingi
D000328:Adult; D015415:Biomarkers / Q000378:metabolism; D002940:Circadian Rhythm / Q000502:physiology*; D004724:Endoscopy; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D006854:Hydrocortisone / Q000378:metabolism*; D008297:Male; D008550:Melatonin / Q000378:metabolism*; D009298:Nasal Polyps / Q000175:diagnosis / Q000378:metabolism*; D011863:Radioimmunoassay; D012189:Retrospective Studies; D012463:Saliva / Q000737:chemistry*; D012720:Severity of Illness Index; D014057:Tomography, X-Ray Computed; D055815:Young Adult
D015415:Biomarkers; D008550:Melatonin; D006854:Hydrocortisone