Saphenous vein aorto-coronary graft atherosclerosis in patients with chronic kidney disease: more plaque calcification and necrosis, but less vasoconstrictor potential.
Atherosclerotic coronary arteries are more calcified in patients with than without chronic kidney disease (CKD). We addressed the potential for coronary microvascular obstruction in patients with and without CKD during stenting for saphenous vein aorto-coronary graft (SVG) stenosis under protection with a distal occlusion/aspiration device. In patients with and without CKD (n = 20/20), SVG plaque composition was analyzed from virtual histology using intravascular ultrasound analysis before stent implantation. There was more dense calcium and more necrotic core in patients with than without CKD (14 ± 3 vs. 3 ± 1 % and 21 ± 3 vs. 12 ± 2 % of plaque volume, respectively). Coronary aspirate was retrieved during stent implantation and divided into particulate debris and plasma. Patients with CKD had more particulate debris and calcium release than patients without CKD. In contrast, the release of serotonin was less in patients with than without CKD (0.4 ± 0.1 vs. 1.2 ± 0.3 μmol/L), whereas that of catecholamines, endothelin, tissue factor, thromboxane, tumor necrosis factor α, and C reactive protein was not significantly different. Confirming the biochemical results, aspirate plasma from patients with CKD induced less vasoconstriction of rat mesenteric arteries than that from patients without CKD (with endothelium (+E), 26 ± 7 %; without endothelium (-E): 28 ± 7 % vs. +E, 68 ± 12 %; -E: 95 ± 16 % of maximum KCl-induced vasoconstriction). Graft atherosclerosis of patients with CKD is more degenerated and releases more particulate debris and calcium, but the aspirate has surprisingly less serotonin and vasoconstrictor potential.
Institut für Pathophysiologie Universitätsklinikum Essen, Universität Duisburg-Essen, Germany.
Theodor
T
Baars
Petra
P
Kleinbongard
Dirk
D
Böse
Thomas
T
Konorza
Stefan
S
Möhlenkamp
Jörg
J
Hippler
Raimund
R
Erbel
Gerd
G
Heusch
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000818:Animals; D050197:Atherosclerosis / Q000097:blood / Q000150:complications / Q000175:diagnosis*; D019917:Blood Vessel Prosthesis Implantation; D002097:C-Reactive Protein / Q000032:analysis; D002118:Calcium / Q000097:blood; D003324:Coronary Artery Disease / Q000097:blood / Q000150:complications / Q000175:diagnosis; D006083:Graft Occlusion, Vascular / Q000097:blood / Q000150:complications / Q000175:diagnosis*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009336:Necrosis; D058226:Plaque, Atherosclerotic / Q000737:chemistry*; D051381:Rats; D051436:Renal Insufficiency, Chronic / Q000150:complications*; D012501:Saphenous Vein; D015607:Stents; D013925:Thromboplastin / Q000032:analysis; D014409:Tumor Necrosis Factor-alpha / Q000032:analysis; D018084:Ultrasonography, Interventional; D061205:Vascular Calcification / Q000150:complications*; D014661:Vasoconstriction; D060749:alpha-2-HS-Glycoprotein / Q000032:analysis
D014409:Tumor Necrosis Factor-alpha; D060749:alpha-2-HS-Glycoprotein; D002097:C-Reactive Protein; D013925:Thromboplastin; D002118:Calcium