Analysis toward innovative herbal antibacterial and antifungal drugs.
The antimicrobial activities of four medicinal plants Argemona mexicana, Achyranthes aspera, Catharanthus roseus, and Syzygium cumini were evaluated against Escherichia coli, Vibrio cholerae, Klebsiella pneumoniae, Proteus vulgaris, Bacillus subtilis, Salmonella typhi and three Aspergillus species. Extracts from Achyranthes aspera and Catharanthus roseus showed the highest antimicrobial potential (MIC 0.375-0.750 mg/ml) while extract from Argemona mexicana and Syzygium cumini, showed less activity. In disc diffusion assay, only eight out of twenty extracts showed antimicrobial activity at a concentration of 25.0 μg/ disc. The GCMS investigation reveals the existence of 2-bornanone; 1, 2-benzenedicarboxylic acid, bis (2-methylpropyl) ester; hexadecanoic acid, methyl ester and hexatriacontane in water extract fraction of C. roseus. The present research article provides a review of some medicinal plants incorporating antimicrobial drugs, together with recent advances in emerging therapeutics in clinical development and related patents for exploitation of herbal medicine.
Centre for Biotechnology, Maharshi Dayanand University, Rohtak -124001, Haryana, India.
Sandeep
S
Dhankhar
Seema
S
Dhankhar
Manish
M
Kumar
Sonam
S
Ruhil
Meenakshi
M
Balhara
Anil K
AK
Chhillar
D000900:Anti-Bacterial Agents / Q000302:isolation & purification / Q000494:pharmacology*; D000935:Antifungal Agents / Q000302:isolation & purification / Q000494:pharmacology*; D001230:Aspergillus / Q000187:drug effects / Q000502:physiology; D030008:Catharanthus; D006801:Humans; D007711:Klebsiella pneumoniae / Q000187:drug effects / Q000502:physiology; D008826:Microbial Sensitivity Tests / Q000379:methods; D010936:Plant Extracts / Q000302:isolation & purification / Q000494:pharmacology*; D018515:Plant Leaves; D028321:Plant Preparations / Q000302:isolation & purification / Q000494:pharmacology*
D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D010936:Plant Extracts; D028321:Plant Preparations