New methymycin derivatives of Streptomyces venezuelae ATCC 15439 and their inhibitory effects on human T cell proliferation mediated by PMA/ionomycin.
Two new methymycin derivatives, 3'-demethylmethymycin (1) and 3'-demethyldeoxymethymycin (2), together with seven known ones (3-9), were obtained from the strain Streptomyces venezuelae ATCC 15439. Their structures were determined on the basis of IR, MS, 1D and 2D NMR data. In addition, the inhibitory effects of all the compounds on human T cell proliferation mediated by PMA/ionomycin were evaluated. The data suggested for the first time that methymycin derivatives have potential anti-inflammatory activity.
College of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang, 110016, China.
Rong
R
Ding
Jinshan
J
Tang
Hao
H
Gao
Ting
T
Li
Hua
H
Zhou
Liang
L
Liu
Xin-Sheng
XS
Yao
D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D001771:Blood Banks; D061207:Calcium Ionophores / Q000633:toxicity; D002273:Carcinogens / Q000633:toxicity; D049109:Cell Proliferation / Q000187:drug effects; D002478:Cells, Cultured; D002851:Chromatography, High Pressure Liquid; D055808:Drug Discovery; D006801:Humans; D015759:Ionomycin / Q000633:toxicity; D008213:Lymphocyte Activation / Q000187:drug effects*; D018942:Macrolides / Q000737:chemistry* / Q000302:isolation & purification / Q000378:metabolism / Q000494:pharmacology*; D008745:Methylation; D015394:Molecular Structure; D009994:Osmolar Concentration; D010084:Oxidation-Reduction; D013302:Streptomyces / Q000378:metabolism*; D013329:Structure-Activity Relationship; D013601:T-Lymphocytes / Q000187:drug effects*; D013755:Tetradecanoylphorbol Acetate / Q000633:toxicity
C578977:3'-demethyldeoxymethymycin; C578976:3'-demethylmethymycin; D000894:Anti-Inflammatory Agents, Non-Steroidal; D061207:Calcium Ionophores; D002273:Carcinogens; D018942:Macrolides; C008517:methymycin; D015759:Ionomycin; D013755:Tetradecanoylphorbol Acetate