Monoterpenoid inhibitors of NO production from Paeonia suffruticosa.
Three pairs of monoterpene glycosides (1-6), of which compounds 1, 3, and 4 as new compounds, together with one new monoterpene (7) were obtained from the ethanol extract of Paeonia suffruticosa Andrews. Their structures were determined on the basis of chemical methods and spectral data. On this basis, the spectral characteristics of three pairs of monoterpene glycosides were also discussed. The inhibitory effects of isolated compounds on nitric oxide (NO) production in lipopolysaccharide-activated macrophages were evaluated, and NO production was suppressed significantly by compounds 4-7.
Department of Natural Products Chemistry, Shenyang Pharmaceutical University, Shenyang 110016, People's Republic of China.
Liqin
L
Ding
Zhihu
Z
Jiang
Yue
Y
Liu
Lixia
L
Chen
Qian
Q
Zhao
Xinsheng
X
Yao
Feng
F
Zhao
Feng
F
Qiu
D000818:Animals; D008070:Lipopolysaccharides / Q000633:toxicity; D051379:Mice; D015394:Molecular Structure; D039821:Monoterpenes / Q000737:chemistry* / Q000494:pharmacology*; D009569:Nitric Oxide / Q000378:metabolism*; D029596:Paeonia / Q000737:chemistry*
D008070:Lipopolysaccharides; D039821:Monoterpenes; D009569:Nitric Oxide