A unique case of blastoid variant of mantle  cell lymphoma with an aberrant CD5-/CD10+/Bcl-6+/CD56+ immunophenotype: a case report.
The neural adhesion molecule CD56 is normally expressed on natural killer cells and subsets of T cells and is commonly found in hematolymphoid neoplasms. Expression of CD56 is very rare in B-cell lymphoma and most reported CD56-positive cases were diffuse large B-cell lymphomas. Cases of CD56-positive mantle cell lymphoma (MCL) have not previously been described in the literature. We present a case of CD56-positive MCL. To the best of our knowledge, this is the first case report of MCL expressing CD56.
Department of Pathology, Ewha Womans University School of Medicine, Seoul, Korea. americandoc@hanmail.net
Sanghui
S
Park
Young Hyeh
YH
Ko
D014408:Biomarkers, Tumor / Q000032:analysis*; D001706:Biopsy; D018956:CD5 Antigens / Q000032:analysis*; D019002:CD56 Antigen / Q000032:analysis*; D002880:Chromosomes, Human, Pair 11; D002883:Chromosomes, Human, Pair 14; D004268:DNA-Binding Proteins / Q000032:analysis*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D016130:Immunophenotyping; D017404:In Situ Hybridization, Fluorescence; D020522:Lymphoma, Mantle-Cell / Q000276:immunology* / Q000473:pathology*; D008875:Middle Aged; D015260:Neprilysin / Q000032:analysis*; D051560:Proto-Oncogene Proteins c-bcl-6; D014067:Tonsillar Neoplasms / Q000276:immunology* / Q000473:pathology*; D014178:Translocation, Genetic
C084103:BCL6 protein, human; D014408:Biomarkers, Tumor; D018956:CD5 Antigens; D019002:CD56 Antigen; D004268:DNA-Binding Proteins; C522918:NCAM1 protein, human; D051560:Proto-Oncogene Proteins c-bcl-6; D015260:Neprilysin