Antiplasmodial and antibacterial activity of compounds isolated from Ormocarpum trichocarpum.
Using activity-guided fractionation based on in vitro antibacterial assays, five biflavonoids, among them two new ones, were isolated from the aerial parts of Ormocarpum trichocarpum. The isolated compounds showed MIC values in the range of 4.0 to 136.7 µM against Staphylococcus aureus, Bacillus subtilis, Escherichia coli, and Klebsiella pneumonia and IC50 values in the range of 4.30 to 94.32 µM against the chloroquine-sensitive D10 Plasmodium falciparum strain.
Research Centre for Plant Growth and Development, School of Life Sciences, University of KwaZulu-Natal Pietermaritzburg, Scottsville, South Africa.
Jude C
JC
Chukwujekwu
Carmen A
CA
de Kock
Peter J
PJ
Smith
Fanie R
FR
van Heerden
Johannes
J
van Staden
D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D000962:Antimalarials / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D001412:Bacillus subtilis / Q000187:drug effects; D044946:Biflavonoids / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D004926:Escherichia coli / Q000187:drug effects; D007887:Fabaceae / Q000737:chemistry*; D020128:Inhibitory Concentration 50; D007711:Klebsiella pneumoniae / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D035261:Plant Components, Aerial / Q000737:chemistry; D010936:Plant Extracts / Q000494:pharmacology; D010963:Plasmodium falciparum / Q000187:drug effects; D013211:Staphylococcus aureus / Q000187:drug effects
D000900:Anti-Bacterial Agents; D000962:Antimalarials; D044946:Biflavonoids; D010936:Plant Extracts