Safety assessment of 1,2-glycols as used in cosmetics.
Caprylyl glycol and related 1,2-glycols are used mostly as skin and hair conditioning agents and viscosity agents in cosmetic products, and caprylyl glycol and pentylene glycol also function as cosmetic preservatives. The Cosmetic Ingredient Review (CIR) Expert Panel noted that, while these ingredients are dermally absorbed, modeling data predicted decreased skin penetration of longer chain 1,2-glycols. Because the negative oral toxicity data on shorter chain 1,2-glycols and genotoxicity data support the safety of the 1,2-glycols reviewed in this safety assessment, the Panel concluded that these ingredients are safe in the present practices of use and concentration described in this safety assessment.
Cosmetic Ingredient Review, 1101 17th Street NW, Washington, DC 20036, USA. cirinfo@cir-safety.org
Wilbur
W
Johnson
Wilma F
WF
Bergfeld
Donald V
DV
Belsito
Ronald A
RA
Hill
Curtis D
CD
Klaassen
Daniel
D
Liebler
James G
JG
Marks
Ronald C
RC
Shank
Thomas J
TJ
Slaga
Paul W
PW
Snyder
F Alan
FA
Andersen
D000279:Administration, Cutaneous; D000818:Animals; D003257:Consumer Product Safety; D003358:Cosmetics / Q000737:chemistry* / Q000633:toxicity; D003879:Dermatologic Agents / Q000008:administration & dosage / Q000737:chemistry / Q000493:pharmacokinetics / Q000633:toxicity*; D006018:Glycols / Q000008:administration & dosage / Q000737:chemistry / Q000493:pharmacokinetics / Q000633:toxicity*; D006801:Humans; D007928:Lethal Dose 50; D019055:No-Observed-Adverse-Effect Level; D000442:Octanols / Q000008:administration & dosage / Q000737:chemistry / Q000493:pharmacokinetics / Q000633:toxicity; D010420:Pentanes / Q000008:administration & dosage / Q000737:chemistry / Q000493:pharmacokinetics / Q000633:toxicity; D017592:Skin Care / Q000009:adverse effects; D018675:Toxicity Tests; D014783:Viscosity
D003358:Cosmetics; D003879:Dermatologic Agents; D006018:Glycols; D000442:Octanols; D010420:Pentanes; C535047:1,2-octanediol; C452500:1,2-pentanediol