Fluorescent polymer-based post-translational differentiation and subtyping of breast cancer cells.
Herein, we report the application of synthesized fluorescent, water soluble polymers for post-translational subtyping and differentiation of breast cancer cells in vitro. The fluorescence emission spectra from these polymers were modulated differently in the presence of conditioned cell culture media from various breast cancer cells. These polymers differentiate at a post-translation level possibly due to their ability to interact with extracellular enzymes that are over-expressed in cancerous conditions.
Department of Pharmaceutical Sciences, North Dakota State University, Fargo, North Dakota 58108-6050, USA. sanku.mallik@ndsu.edu
Michael D
MD
Scott
Rinku
R
Dutta
Manas K
MK
Haldar
Anil
A
Wagh
Thomas R
TR
Gustad
Benedict
B
Law
Daniel L
DL
Friesner
Sanku
S
Mallik
D001943:Breast Neoplasms / Q000145:classification* / Q000235:genetics / Q000473:pathology; D045744:Cell Line, Tumor; D017077:Culture Media, Conditioned; D018432:Drug Resistance, Multiple; D019008:Drug Resistance, Neoplasm; D005260:Female; D005456:Fluorescent Dyes; D057809:HEK293 Cells; D006367:HeLa Cells; D006801:Humans; D008667:Metalloproteins / Q000032:analysis / Q000037:antagonists & inhibitors; D011108:Polymers; D013050:Spectrometry, Fluorescence
D017077:Culture Media, Conditioned; D005456:Fluorescent Dyes; D008667:Metalloproteins; D011108:Polymers