Interstitial lung disease in a patient with chronic granulomatous disease.
BACKGROUND
Chronic granulomatous disease (CGD) is an inherited phagocytes defect, characterized by defects of NADPH-oxidase and inability of bacterial killing, which leads to recurrent life-threatening infections. Respiratory problems, which are the major cause of morbidity in CGD, usually result from recurrent severe infections; however, vigorous inflammatory response could also cause respiratory diseases.


METHODS
Herein, an 11 year-old patient with CGD is presented who suffered from chronic cough and dyspnea for 7 years. Considering the results of chest X-ray, high-resolution computed tomography, and pulmonary function test, the diagnosis of interstitial lung disease was made.


CONCLUSIONS
Early recognition of manifestations associated with CGD and appropriate treatment could prevent further complications and reduce morbidity and mortality in this group of patients.
Allergy Research Center, Shiraz University of Medical Sciences, Shiraz, Iran ; Department of Pediatrics, Division of Immunology and Allergy, Shiraz University of Medical Sciences, Shiraz, Iran.
Mozhgan
M
Moghtaderi
Sara
S
Kashef
Nima
N
Rezaei