Primary clear cell carcinoma of minor salivary gland of the soft palate: a case report.
Clear cells can be found in numerous salivary and non-salivary tumors in the head and neck region, including metastatic lesions. They are rare low-grade tumors accounting for less than 1% of all salivary gland tumors and occur almost exclusively in the intra-oral minor salivary glands. Hyalinizing clear cell carcinoma (HCCC) is an extremely rare and recently described neoplasm predominantly affecting the oral cavity. Histologically, it is characterized by nests of glycogen-rich monomorphic clear cells within a hyaline stroma. HCCC often follows an indolent course with a limited metastatic potential. It is therefore important to differentiate this entity from other more aggressive clear cell tumors including metastatic tumors such as renal cell carcinoma. We hereby report a case of HCCC localized in minor salivary glands specifically in soft palate for its rarity, as well as to discuss the role of immunohistochemical stains, essential for its definitive diagnosis.
Department of Otorhinolaryngology, Head and Neck Surgery, Medical Faculty, University Kebangsaan Malaysia Medical Center, Jalan Yaacob Latif, 56000 Cheras, Kuala Lumpur. talibaliraqi2002@yahoo.com
K A
KA
Saleh
M Isa
MI
Nurishmah
G N
GN
Firouzeh
B S
BS
Goh
D000328:Adult; D002277:Carcinoma / Q000175:diagnosis / Q000473:pathology*; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D012468:Salivary Gland Neoplasms / Q000175:diagnosis / Q000473:pathology*