microRNA-based cancer cell reprogramming technology.
Epigenetic modifications play crucial roles in cancer initiation and development. Complete reprogramming can be achieved through the introduction of defined biological factors such as Oct4, Sox2, Klf4, and cMyc into mouse and human fibroblasts. Introduction of these transcription factors resulted in the modification of malignant phenotype behavior. Recent studies have shown that human and mouse somatic cells can be reprogrammed to become induced pluripotent stem cells using forced expression of microRNAs, which completely eliminates the need for ectopic protein expression. Considering the usefulness of RNA molecules, microRNA-based reprogramming technology may have future applications in regenerative and cancer medicine.
Departments of Frontier Science for Cancer and Chemotherapy and ; Gastroenterological Surgery, Osaka University, Graduate School of Medicine, Suita, Osaka 565-0871,  Japan.
Shimpei
S
Nishikawa
Hideshi
H
Ishii
Naotsugu
N
Haraguchi
Yoshihiro
Y
Kano
Takahito
T
Fukusumi
Katsuya
K
Ohta
Miyuki
M
Ozaki
Dyah Laksmi
DL
Dewi
Daisuke
D
Sakai
Taroh
T
Satoh
Hiroaki
H
Nagano
Yuichiro
Y
Doki
Masaki
M
Mori