A bovine whey protein extract can induce the generation of regulatory T cells and shows potential to alleviate asthma symptoms in a murine asthma model.
The number of people with asthma has dramatically increased over the past few decades and the cost of care is more than $11·3 billion per year. The use of steroids is the major treatment to control asthma symptoms, but the side effects are often devastating. Seeking new drugs or new strategies to reduce the dose of steroid taken has always been an important task. A bovine whey protein extract (WPE), which is enriched in transforming growth factor-β (TGF-β), has been demonstrated to have the potential for reducing symptoms associated with mild-to-moderate T-helper cell type 1-mediated psoriasis in human subjects. However, whether WPE also has potential for inhibiting T-helper cell type 2 (Th2)-mediated disease remains unclear. In the present study, using a murine asthma model, we found that sensitised mice fed WPE daily, before they were challenged, resulted in reducing airway inflammation, serum ovalbumin-specific IgE, Th2-related cytokine production and airway hyperresponsiveness. Increase in the regulatory T cell (Treg) population in vitro and in vivo was observed when treated with WPE. According to the results from the TGF-β-blocking antibody study, we suggest that TGF-β is the main component that endows WPE with the potential to reduce the generation of Treg. Thus, the present data suggest that WPE has the potential to alleviate the symptoms of asthma by inducing the generation of Treg. Therefore, regular administration of WPE might be potentially beneficial for patients with asthma.
Division of Rheumatology, Department of Medicine, China Medical University Hospital, Taichung, Taiwan, ROC.
Jiunn-Horng
JH
Chen
Po-Han
PH
Huang
Chen-Chen
CC
Lee
Pin-Yu
PY
Chen
Hui-Chen
HC
Chen
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology / Q000627:therapeutic use*; D001249:Asthma / Q000097:blood / Q000150:complications / Q000188:drug therapy* / Q000276:immunology; D002417:Cattle; D016207:Cytokines / Q000096:biosynthesis; D004195:Disease Models, Animal; D005260:Female; D007073:Immunoglobulin E / Q000097:blood; D007249:Inflammation / Q000097:blood / Q000188:drug therapy* / Q000276:immunology; D051379:Mice; D008807:Mice, Inbred BALB C; D008894:Milk Proteins / Q000494:pharmacology / Q000627:therapeutic use*; D010047:Ovalbumin / Q000276:immunology; D050378:T-Lymphocytes, Regulatory / Q000187:drug effects*; D018418:Th2 Cells / Q000187:drug effects*; D016212:Transforming Growth Factor beta / Q000494:pharmacology; D000067816:Whey Proteins
D000893:Anti-Inflammatory Agents; D016207:Cytokines; D008894:Milk Proteins; D016212:Transforming Growth Factor beta; D000067816:Whey Proteins; D007073:Immunoglobulin E; D010047:Ovalbumin