Stability of colistimethate sodium in aqueous solution.
Colistimethate sodium, increasingly used to treat multidrug-resistant Gram-negative infections, spontaneously hydrolyzes to form colistin A (polymyxin E1) and B (polymyxin E2/B) when mixed with water. High levels of these active breakdown products at the time of administration have been associated with nephrotoxicity and even death. In this study, reconstituted colistimethate sodium was shown to be stable (<1.0% colistin A/B formation) for up to 24 h when stored at 21, 0, -20, and -70°C.
Division of Infectious Diseases and HIV Medicine, Case Western Reserve University, Cleveland, OH, USA. amb233@case.edu
A M
AM
Healan
W
W
Gray
E J
EJ
Fuchs
J M
JM
Griffiss
R A
RA
Salata
J
J
Blumer
D000900:Anti-Bacterial Agents / Q000737:chemistry*; D003091:Colistin / Q000031:analogs & derivatives* / Q000737:chemistry; D004339:Drug Compounding; D004355:Drug Stability; D019999:Pharmaceutical Solutions; D053719:Tandem Mass Spectrometry; D013696:Temperature; D014867:Water
D000900:Anti-Bacterial Agents; D019999:Pharmaceutical Solutions; D014867:Water; C004691:colistinmethanesulfonic acid; D003091:Colistin