Role of mitochondria in programmed cell death mediated by arachidonic acid-derived eicosanoids.
Arachidonic acid-derived eicosanoids from cyclooxygenases, lipoxygenases, and cytochrome P450 are important lipid mediators involved in numerous homeostatic and pathophysiological processes. Most eicosanoids act primarily on their respective cell surface G-protein coupled receptors to elicit downstream signaling in an autocrine and paracrine fashion. Emerging evidence indicates that these hormones are also critical in apoptosis in a cell/tissue specific manner. In this review, we summarize the formation of eicosanoids and their roles as mediators in apoptosis, specifically on the roles of mitochondria in mediating these events and the signaling pathways involved. The biological relevance of eicosanoid-mediated apoptosis is also discussed.
Laboratory of Lipid Metabolism in Human Nutrition and Related Diseases, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China. hyyin@sibs.ac.cn
Huiyong
H
Yin
Yunhua
Y
Zhou
Mingjiang
M
Zhu
Sarina
S
Hou
Zi
Z
Li
Huiqin
H
Zhong
Jianhong
J
Lu
Tao
T
Meng
Junhong
J
Wang
Lin
L
Xia
Yue
Y
Xu
Yuncheng
Y
Wu
D000818:Animals; D017209:Apoptosis / Q000502:physiology*; D015777:Eicosanoids / Q000235:genetics / Q000378:metabolism*; D006706:Homeostasis / Q000502:physiology; D006801:Humans; D008928:Mitochondria / Q000201:enzymology* / Q000235:genetics; D010088:Oxidoreductases / Q000235:genetics / Q000378:metabolism*; D043562:Receptors, G-Protein-Coupled / Q000235:genetics / Q000378:metabolism; D015398:Signal Transduction / Q000502:physiology*
D015777:Eicosanoids; D043562:Receptors, G-Protein-Coupled; D010088:Oxidoreductases