Geographic information system-based screening for TB, HIV, and syphilis (GIS-THIS): a cross-sectional study.
OBJECTIVE
To determine the feasibility and case detection rate of a geographic information systems (GIS)-based integrated community screening strategy for tuberculosis, syphilis, and human immunodeficiency virus (HIV).


METHODS
Prospective cross-sectional study of all participants presenting to geographic hot spot screenings in Wake County, North Carolina.


METHODS
The residences of tuberculosis, HIV, and syphilis cases incident between 1/1/05-12/31/07 were mapped. Areas with high densities of all 3 diseases were designated "hot spots." Combined screening for tuberculosis, HIV, and syphilis were conducted at the hot spots; participants with positive tests were referred to the health department.


CONCLUSIONS
Participants (N = 247) reported high-risk characteristics: 67% previously incarcerated, 40% had lived in a homeless shelter, and 29% had a history of crack cocaine use. However, 34% reported never having been tested for HIV, and 41% did not recall prior tuberculin skin testing. Screening identified 3% (8/240) of participants with HIV infection, 1% (3/239) with untreated syphilis, and 15% (36/234) with latent tuberculosis infection. Of the eight persons with HIV, one was newly diagnosed and co-infected with latent tuberculosis; he was treated for latent TB and linked to an HIV provider. Two other HIV-positive persons had fallen out of care, and as a result of the study were linked back into HIV clinics. Of 27 persons with latent tuberculosis offered therapy, nine initiated and three completed treatment. GIS-based screening can effectively penetrate populations with high disease burden and poor healthcare access. Linkage to care remains challenging and will require creative interventions to impact morbidity.
Department of Medicine, Duke University Medical Center, Durham, North Carolina, United States of America. neela.goswami@duke.edu
Neela D
ND
Goswami
Emily J
EJ
Hecker
Carter
C
Vickery
Marshall A
MA
Ahearn
Gary M
GM
Cox
David P
DP
Holland
Susanna
S
Naggie
Carla
C
Piedrahita
Ann
A
Mosher
Yvonne
Y
Torres
Brianna L
BL
Norton
Sujit
S
Suchindran
Paul H
PH
Park
Debbie
D
Turner
Jason E
JE
Stout
D000328:Adult; D003430:Cross-Sectional Studies; D005240:Feasibility Studies; D005260:Female; D005500:Follow-Up Studies; D040362:Geographic Information Systems / Q000706:statistics & numerical data*; D005843:Geography; D015658:HIV Infections / Q000175:diagnosis / Q000453:epidemiology / Q000517:prevention & control*; D006801:Humans; D015994:Incidence; D008297:Male; D008403:Mass Screening / Q000379:methods / Q000706:statistics & numerical data*; D008875:Middle Aged; D009657:North Carolina / Q000453:epidemiology; D011446:Prospective Studies; D013587:Syphilis / Q000175:diagnosis / Q000453:epidemiology / Q000517:prevention & control*; D014376:Tuberculosis / Q000175:diagnosis / Q000453:epidemiology / Q000517:prevention & control*; D055815:Young Adult