Lymphocyte subsets in pediatric migraine.
Aseptic inflammation due to activated immune cells has been implicated in the pathomechanism of migraine. We measured the prevalence of regulatory T cells (Tregs), along with that of CD4(+)/CD8(+) lymphocytes and their Th1/Th2 commitment in pediatric migraine. Children and adolescents suffering from migraine without aura, migraine with aura and hemiplegic migraine ictally (n = 53, 27, and 20, respectively), also interictally (n = 33) were recruited and compared to 24 healthy children. Our results indicated comparable prevalence of Tregs, CD4(+) and Th1/Th2 committed cells. CD8(+) prevalence was lower, and CD4(+)/CD8(+) ratio was higher in ictal phase irrespective of the subtype of migraine. No association between CD8(+) prevalence and gender, body weight, disease onset and attack duration in migraine subtypes was found. CD8(+) prevalence was normal in patients in interictal phase. These results suggest the absence of major systemic alteration of adaptive immunity in children and adolescents suffering from migraine; however, a transient decrease of CD8(+) prevalence during the ictal phase was detected irrespective of the subtype of migraine.
Research Group for Pediatrics and Nephrology, Semmelweis University and Hungarian Academy of Sciences, Bókay u. 53-54, Budapest 1083, Hungary. cseharon@gmail.com
Aron
A
Cseh
Kristof Mark
KM
Farkas
Laszlo
L
Derzbach
Katalin
K
Muller
Barna
B
Vasarhelyi
Balazs
B
Szalay
Andras
A
Treszl
Viktor
V
Farkas
D000293:Adolescent; D000367:Age Factors; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D016131:Lymphocyte Subsets / Q000276:immunology / Q000378:metabolism* / Q000473:pathology; D008297:Male; D008881:Migraine Disorders / Q000097:blood* / Q000175:diagnosis* / Q000276:immunology / Q000473:pathology