Genetic variant in KIAA0319, but not in DYX1C1, is associated with risk of dyslexia: an integrated meta-analysis.
DYX1C1 and KIAA0319 have been two of the most extensively studied candidate genes for dyslexia given their important roles in the neuronal migration and neurite growth. The -3G > A in DYX1C1 and the 931C > T in KIAA0319 were of special interest for dyslexia but with inconsistent results. We performed a meta-analysis integrating case-control and transmission/disequilibrium test (TDT) studies to clearly discern the effect of these two variants in dyslexia. Data from case-control and TDT studies were analyzed in an allelic model using the Catmap software. In overall meta-analysis, the pooled OR for the -3A allele and the 931T allele was 0.68 (95% CI = 0.25-1.87, P(heterogeneity) = 0.000) and 0.87 (95% CI = 0.78-0.98, P(heterogeneity)= 0.125), respectively. The stratified analysis showed that the between-study heterogeneity regarding the -3G > A polymorphism might be accounted by the publication year. Additionally, the sensitivity analysis of -3G > A polymorphism indicated the stability of the result. In conclusion, our results suggested that the 931C > T variant in KIAA0319, but not the -3G > A in DYX1C1, was significantly associated with the risk of dyslexia.
Department of Maternal and Child Health, School of Public Health, Tongji Medical College, Huangzhong University of Science and Technology, Wuhan, China.
Li
L
Zou
Wei
W
Chen
Shanshan
S
Shao
Zhao
Z
Sun
Rong
R
Zhong
Junxin
J
Shi
Xiaoping
X
Miao
Ranran
R
Song
D016022:Case-Control Studies; D003598:Cytoskeletal Proteins; D004410:Dyslexia / Q000235:genetics*; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006801:Humans; D009419:Nerve Tissue Proteins / Q000235:genetics*; D009687:Nuclear Proteins / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide
D003598:Cytoskeletal Proteins; C478878:DNAAF4 protein, human; C500377:KIAA0319 protein, human; D009419:Nerve Tissue Proteins; D009687:Nuclear Proteins