The preventive and therapeutic effects of intravenous human adipose-derived stem cells in Alzheimer's disease mice.
Alzheimer's disease (AD) is characterized by the accumulation of amyloid plaques and neurofibrillary tangles accompanied by cognitive dysfunction. The aim of the present study was to elucidate preventive and therapeutic potential of stem cells for AD. Among stem cells, autologous human adipose-derived stem cells (hASCs) elicit no immune rejection responses, tumorigenesis, or ethical problems. We found that intravenously transplanted hASCs passed through the BBB and migrated into the brain. The learning, memory and pathology in an AD mouse model (Tg2576) mice greatly improved for at least 4 months after intravenous injection of hASC. The number of amyloid plaques and Aβ levels decreased significantly in the brains of hASC-injected Tg mice compared to those of Tg-sham mice. Here, we first report that intravenously or intracerebrally transplanted hASCs significantly rescues memory deficit and neuropathology, in the brains of Tg mice by up-regulating IL-10 and VEGF and be a possible use for the prevention and treatment of AD.
Department of Pharmacology, College of Medicine, Neuroscience Research Institute, MRC, Seoul National University, Seoul, South Korea.
Saeromi
S
Kim
Keun-A
KA
Chang
Jeong a
Ja
Kim
Hyeong-Geun
HG
Park
Jeong Chan
JC
Ra
Hye-Sun
HS
Kim
Yoo-Hun
YH
Suh
D000273:Adipose Tissue / Q000166:cytology*; D000544:Alzheimer Disease / Q000378:metabolism*; D058227:Amyloidogenic Proteins / Q000378:metabolism; D000818:Animals; D001921:Brain / Q000378:metabolism; D064987:Cell- and Tissue-Based Therapy / Q000379:methods*; D004195:Disease Models, Animal; D005260:Female; D005786:Gene Expression Regulation; D006801:Humans; D007275:Injections, Intravenous; D016753:Interleukin-10 / Q000378:metabolism; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008822:Mice, Transgenic; D008856:Microscopy, Fluorescence / Q000379:methods; D013997:Time Factors; D015854:Up-Regulation; D042461:Vascular Endothelial Growth Factor A / Q000378:metabolism
D058227:Amyloidogenic Proteins; D042461:Vascular Endothelial Growth Factor A; D016753:Interleukin-10