WW domains in the heart of Smad regulation.
WW domains are small modules that mediate protein/protein interactions. In this issue of Structure, Aragón and colleagues show that a WW domain of YAP can mediate complexes with either the canonical PY motif in an inhibitory Smad or engage in phosphorylation-dependent complexes with one of the activated Smads. The propensity of YAP WW to recognize a pSP motif is a surprising find with a number of far-reaching ramifications.
Weis Center for Research, Geisinger Clinic, 100 North Academy Avenue, Danville, PA 17821, USA. msudol1@geisinger.edu
Marius
M
Sudol