Cardiac markers: profile in rats experimentally infected with Toxocara canis.
The aim of this study was to evaluate the profile of the enzymes creatine kinase (CK), creatine kinase MB (CK-MB) and lactate dehydrogenase (LDH) in Wistar rats infected with 250 (GI, n = 24) or 1000 (GII, n = 24) Toxocara canis eggs. Animals were evaluated on days 7, 15, 30, 60, 120 and 180 post-infection (DPI). Only the GI rats showed an increase in CK and CK-MB, at 15 and 30 DPI, respectively. Anti-Toxocara spp. antibodies were detected by ELISA in infected animals. Despite of the presence of eosinophilic infiltrate in the heart of three infected animals, none larva was recovered from the organ neither by acid digestion nor by Baermann procedure. Eosinophilia was observed in both groups but there was no significant difference in the eosinophil counts between GI and GII (p = 0.2239). It is possible to consider that cardiac lesion is an eventual finding in murine model for toxocariasis.
Laboratório de Patologia Clínica, Curso de Pós-graduação em Ciência Animal Hospital Veterinário, Universidade do Oeste Paulista, Presidente Prudente, SP, Brasil.
Cecília Braga
CB
Laposy
Selma de Bastos Zambelli
Sde B
Freitas
André Nogueira
AN
Louzada
Guita
G
Rubinsky-Elefant
Rogério
R
Giuffrida
Rosa Maria Barili
RM
Nogueira
Vamilton Alvares
VA
Santarém
D000818:Animals; D003402:Creatine Kinase / Q000097:blood*; D052279:Creatine Kinase, MB Form / Q000097:blood; D005260:Female; D006331:Heart Diseases / Q000097:blood / Q000469:parasitology / Q000662:veterinary; D007770:L-Lactate Dehydrogenase / Q000097:blood*; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D017166:Toxocara canis; D014120:Toxocariasis / Q000097:blood*
D007770:L-Lactate Dehydrogenase; D003402:Creatine Kinase; D052279:Creatine Kinase, MB Form