[Research advances on circumsporozoite protein of Plasmodium].
Circumsporozoite protein (CSP) is found in all the mature malaria parasites, which forms a dense coat on the sporozoite's surface. CSPs contain approximately 400 amino acids and are organized into three domains: an N-terminal domain containing a conserved pentapeptide called region I, a highly repetitive species-specific central domain, and a C-terminal domain containing another conserved sequence called region II. It has been reported that the CSP fulfills vital roles in invading to the mosquito's salivary glands, binding sporozoite to liver cells, and inactivating host cell protein synthesis machinery. Recently, researches pointed out that both of the vaccine and the targeted-drug-delivery-system based on CSP antigen reveal an immense prospect. This review presents a compilation of the protein at the molecular characterization, function and application level that have been described to date.
Institute of Pharmaceutical Bioactive Substances, Guangdong Pharmaceutical College, Guangzhou 510006, China.
Yan-Ting
YT
Huang
Xue-Mei
XM
Lu
Xiao-Bao
XB
Jin
Jia-Yong
JY
Zhu
D000595:Amino Acid Sequence; D017780:Malaria Vaccines; D015800:Protozoan Proteins / Q000235:genetics* / Q000276:immunology*
D017780:Malaria Vaccines; D015800:Protozoan Proteins; C041595:circumsporozoite protein, Protozoan