Cancer biology: a new RING to Wnt signaling.
The β-catenin-dependent Wnt signaling pathway has key roles in embryonic development and adult tissues and is defective in various cancers. Recent studies highlight the function of two transmembrane RING finger ubiquitin ligases in modulating Wnt signaling and reveal roles for mutations in the RING finger proteins in cancer.
Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI 48109, USA. fearon@med.umich.edu
Eric R
ER
Fearon
Jason R
JR
Spence
D000818:Animals; D004268:DNA-Binding Proteins / Q000378:metabolism*; D004705:Endocytosis; D005260:Female; D006801:Humans; D008297:Male; D015513:Oncogene Proteins / Q000378:metabolism*; D060490:Receptors, Wnt / Q000378:metabolism*; D013234:Stem Cells / Q000201:enzymology*; D019699:Thrombospondins / Q000378:metabolism*; D025521:Tumor Suppressor Proteins / Q000378:metabolism*; D044767:Ubiquitin-Protein Ligases / Q000172:deficiency* / Q000378:metabolism*; D060449:Wnt Signaling Pathway
D004268:DNA-Binding Proteins; D015513:Oncogene Proteins; D060490:Receptors, Wnt; D019699:Thrombospondins; D025521:Tumor Suppressor Proteins; D044767:Ubiquitin-Protein Ligases