Stereoselective synthesis of cyclic amino acids via asymmetric phase-transfer catalytic alkylation.
An asymmetric synthesis of cyclic amino acids having piperidine and azepane core structures was realized starting from readily available glycine and alanine esters by combination of phase-transfer catalyzed asymmetric alkylation and subsequent reductive amination.
Department of Chemistry, Graduate School of Science, Kyoto University, Sakyo, Kyoto 606-8502, Japan.
Taichi
T
Kano
Takeshi
T
Kumano
Ryu
R
Sakamoto
Keiji
K
Maruoka
D000478:Alkylation; D000586:Amination; D000598:Amino Acids, Cyclic / Q000138:chemical synthesis* / Q000737:chemistry*; D002384:Catalysis; D002625:Chemistry, Organic / Q000379:methods*; D004952:Esters / Q000138:chemical synthesis / Q000737:chemistry; D044367:Phase Transition; D013237:Stereoisomerism
D000598:Amino Acids, Cyclic; D004952:Esters