Acute effects of intrapulmonary percussive ventilation in COPD patients assessed by using conventional outcome parameters and a novel computational fluid dynamics technique.
OBJECTIVE
Chest physiotherapy enhances sputum evacuation in COPD patients. It can be applied as a single technique or as a combination of techniques including intrapulmonary percussive ventilation (IPV). Recently developed assessment techniques may provide new insights into the effect of airway clearance techniques.


METHODS
Five moderate to severe COPD patients (three females and two males; mean forced expiratory volume in 1 second of 39.49% predicted) who were admitted in the hospital for an acute exacerbation were included in this study.


METHODS
A novel imaging technique was used, together with other conventional techniques, to visualize the short-term effects of a single IPV treatment in COPD patients.


RESULTS
No significant changes were noted in the lung function parameters or arterial blood gases measured within 1 hour after the end of the IPV session. Computed tomography images detected changes in the airway patency after the IPV treatment compared with before treatment. Local resistances, calculated for the three-dimensional models, showed local changes in airway resistance.


CONCLUSIONS
The effects of a single IPV session can be visualized by functional imaging. This functional imaging allows a calculation of changes in local airway resistance and local changes in airway volume in COPD patients without affecting conventional lung function parameters.
Department of Health Science, Artesis University College of Antwerp, Merksem, Belgium. kris.ides@artesis.be
Kris
K
Ides
Wim
W
Vos
Lieve
L
De Backer
Dirk
D
Vissers
Rita
R
Claes
Glenn
G
Leemans
Kevin
K
Ongena
Oswald
O
Peters
Wilfried
W
De Backer
D000403:Airway Resistance; D001530:Belgium; D001784:Blood Gas Analysis; D003198:Computer Simulation; D005260:Female; D005541:Forced Expiratory Volume; D006760:Hospitalization; D006801:Humans; D057446:Hydrodynamics; D021621:Imaging, Three-Dimensional; D008168:Lung / Q000000981:diagnostic imaging* / Q000503:physiopathology; D008176:Lung Volume Measurements; D008297:Male; D008954:Models, Biological; D011237:Predictive Value of Tests; D029424:Pulmonary Disease, Chronic Obstructive / Q000000981:diagnostic imaging* / Q000503:physiopathology / Q000628:therapy*; D011857:Radiographic Image Interpretation, Computer-Assisted / Q000379:methods*; D012121:Respiration, Artificial / Q000379:methods*; D012138:Respiratory Therapy / Q000379:methods*; D012720:Severity of Illness Index; D013997:Time Factors; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome