Synthesis and in vitro antimicrobial activity of novel 2-(3-oxo-1,3-diarylpropylthio)acetic acid derivatives.
A series of novel 2-(3-oxo-1,3-diarylpropylthio)acetic acid derivatives (3a-l) were prepared by base catalyzed addition of thioglycolic acid to chalcones (1a-l). The antibacterial activities of synthesized compounds were screened against human pathogenic microorganisms by employing the disk-diffusion technique. For the active compounds, also minimum inhibitory concentrations (MICs) were determined.
Department of Chemistry, Faculty of Arts and Sciences, Gaziosmanpasa University, 60250 Tokat, Turkey. hayrettin.gezegen@gop.edu.tr
Hayreddin
H
Gezegen
Isa
I
Karaman
Mustafa
M
Ceylan
Merve
M
Dilmaç
D000890:Anti-Infective Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects; D047188:Chalcones / Q000737:chemistry; D008826:Microbial Sensitivity Tests; D013864:Thioglycolates / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D015003:Yeasts / Q000187:drug effects
D000890:Anti-Infective Agents; D047188:Chalcones; D013864:Thioglycolates; C017487:2-mercaptoacetate