Effect of platelet rich plasma on bone regeneration in maxillary sinus augmentation (randomized clinical trial).
This study evaluates bone quality in sinus augmented with autogenous bone with or without platelet rich plasma (PRP) mix. 15 partially edentulous patients requiring maxillary sinus floor augmentation, followed by implant insertion were studied. In group I, 5 patients underwent maxillary sinus lifting with autogenous bone augmentation and implant insertion at 6 months post grafting. In group II, 10 patients underwent maxillary sinus lifting with autogenous bone augmentation mixed with PRP prepared from the patient's own blood with implant insertion at 4 or 6 months post grafting (n=5 for each implantation time). A core biopsy was taken at the time of implant placement for histological and histomorphometric evaluation. Immediately and 3 months after implantation, group I showed the statistically significant highest mean bone density (p=0.046 and 0.022, respectively). At 6 months post-implantation, Group II showed the statistically significant highest mean bone density (p=0.041). Histomorphometric analysis showed that group I had the statistically significant highest mean value (39.5±7.4; p=0.003). Enrichment with PRP did not significantly improve bone density or morphometric value at 3 months post grafting. PRP enriched bone grafts were associated with superior bone density at 6 months post grafting.
Oral Surgery Department, Faculty of Oral & Dental Medicine, Cairo University, Egypt.
N M
NM
Khairy
E E
EE
Shendy
N A
NA
Askar
D H
DH
El-Rouby
D000328:Adult; D000704:Analysis of Variance; D015519:Bone Density / Q000187:drug effects; D001861:Bone Regeneration / Q000187:drug effects*; D016025:Bone Transplantation; D003758:Dental Implantation, Endosseous; D005260:Female; D005500:Follow-Up Studies; D016557:Guided Tissue Regeneration, Periodontal; D006801:Humans; D008297:Male; D008875:Middle Aged; D010982:Platelet-Derived Growth Factor / Q000494:pharmacology*; D053657:Platelet-Rich Plasma; D059546:Sinus Floor Augmentation / Q000379:methods*; D018709:Statistics, Nonparametric; D016896:Treatment Outcome; D055815:Young Adult
D010982:Platelet-Derived Growth Factor