[Combined palliative hypofractionated radiation and carboplatin chemotherapy of intranasal tumours in dogs].
OBJECTIVE
Combination therapy of intranasal tumours in dogs with palliative 60 cobalt radiation and carboplatin chemotherapy.


METHODS
Twenty-five dogs with intranasal tumours were treated in the Hofheim Veterinary Hospital (Germany) from 2004 to 2006 with a total radiation dose of 24Gy (3 fractions of 8 Gy on days 0, 7 and 21) and five doses of Carboplatin (270-300 mg/m² BSA i.v. every 21-28 days).


RESULTS
In 88% patients, clinical symptoms subsided partially or completely resulting in improvement in quality of life. Computed tomography revealed partial (5/25) or complete (5/25) tumour remissions. Chemotherapy was well tolerated. Radiation therapy caused no or minimal side effects except for 3 dogs (12%), which experienced serious ocular side effects resulting in loss of vision of the affected eye and one dog with epileptic seizures. Survival times ranged from 10-639 days with a median of 156 days. There was no statistically significant correlation between the parameters breed, age, sex, brain invasion or tumour stage and survival time or progression free interval. Survival time and progression free interval were significantly correlated with the degree of tumour remission.


CONCLUSIONS
It can be concluded from this study that palliative radiation therapy combined with chemotherapy results in excellent palliation of clinical symptoms and acceptable survival times. There was no advantage of combined therapy (radiation with carboplatin) when compared to literature data on results of radiation therapy alone.
Tierklinik Hofheim, Im Langgewann 9, Hofheim. A.Schwietzer@tierklinik-hofheim.de
A
A
Schwietzer
M
M
Kessler
B
B
Kandel-Tschiederer
D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage*; D016190:Carboplatin / Q000008:administration & dosage*; D059248:Chemoradiotherapy / Q000662:veterinary; D003037:Cobalt Radioisotopes / Q000627:therapeutic use; D004283:Dog Diseases / Q000188:drug therapy* / Q000532:radiotherapy*; D004285:Dogs; D019583:Dose Fractionation, Radiation; D009669:Nose Neoplasms / Q000188:drug therapy / Q000532:radiotherapy / Q000662:veterinary*; D065126:Palliative Medicine / Q000379:methods*
D000970:Antineoplastic Agents; D003037:Cobalt Radioisotopes; D016190:Carboplatin