Surface design of core-shell superparamagnetic iron oxide nanoparticles drives record relaxivity values in functional MRI contrast agents.
Core-shell hydrophilic superparamagnetic iron oxide (SPIO) nanoparticles, surface functionalized with either terephthalic acid or 2-amino terephthalic acid, showed large negative MRI contrast ability, validating the advantage of using low molecular weight and π-conjugated canopies for engineering functional nanostructures with superior performances.
Regional Centre of Advanced Technologies and Materials, Palacky University, Olomouc, Czech Republic.
Dipak
D
Maity
Giorgio
G
Zoppellaro
Veronika
V
Sedenkova
Jiri
J
Tucek
Klara
K
Safarova
Katerina
K
Polakova
Katerina
K
Tomankova
Clemens
C
Diwoky
Rudolf
R
Stollberger
Libor
L
Machala
Radek
R
Zboril
D000818:Animals; D003287:Contrast Media / Q000737:chemistry* / Q000633:toxicity; D015195:Drug Design; D005290:Ferric Compounds / Q000737:chemistry* / Q000633:toxicity; D008279:Magnetic Resonance Imaging / Q000379:methods*; D059346:Magnets / Q000737:chemistry* / Q000633:toxicity; D051379:Mice; D041681:NIH 3T3 Cells; D013499:Surface Properties
D003287:Contrast Media; D005290:Ferric Compounds; C000499:ferric oxide