Photodynamic and photothermal effects of semiconducting and metallic-enriched single-walled carbon nanotubes.
Semiconducting and metallic single-walled carbon nanotubes (s-SWNTs and m-SWNTs) were enriched by agarose gel chromatography and their photothermal and photodynamic effects were compared in H(2)O. Under near-infrared laser irradiation, s-SWNTs generated reactive oxygen species (ROS) more than m-SWNTs, whereas m-SWNTs produced heat more efficiently than s-SWNTs. More importantly, cancer cell killing by PDE of s-SWNTs has been disclosed for the first time.
Institute for Integrated Cell-Material Sciences (WPI-iCeMS), Graduate School of Pharmaceutical Sciences, Kyoto University, Sakyo-ku, Kyoto 606-8501, Japan. murakami@icems.kyoto-u.ac.jp
Tatsuya
T
Murakami
Hirotaka
H
Nakatsuji
Mami
M
Inada
Yoshinori
Y
Matoba
Tomokazu
T
Umeyama
Masahiko
M
Tsujimoto
Seiji
S
Isoda
Mitsuru
M
Hashida
Hiroshi
H
Imahori
D000970:Antineoplastic Agents / Q000737:chemistry / Q000494:pharmacology*; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D037742:Nanotubes, Carbon / Q000737:chemistry*; D017319:Photosensitizing Agents / Q000737:chemistry / Q000494:pharmacology*; D017382:Reactive Oxygen Species / Q000378:metabolism; D012666:Semiconductors; D013329:Structure-Activity Relationship; D013696:Temperature
D000970:Antineoplastic Agents; D037742:Nanotubes, Carbon; D017319:Photosensitizing Agents; D017382:Reactive Oxygen Species