Following the cycle: finally, a transgenic mouse to sort live replicating cells.
Studies of the mammalian cell cycle in vivo have been hampered by the lack of pure populations of proliferating cells. In this issue of Developmental Cell, Klochendler and colleagues (2012) develop a novel transgenic mouse that expresses Cyclin B1-GFP ubiquitously. By sorting and analyzing proliferating hepatocytes, they provide evidence for their transient dedifferentiation.
Department of Genetics and Institute for Diabetes, Obesity & Metabolism, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA. kaestner@mail.med.upenn.edu
Klaus H
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Kaestner