[Research progress of cell dedifferentiation induced by reversine].
OBJECTIVE
To review the research progress of different ways of stem cells generation and cells dedifferentiation induced by reversine.


METHODS
The papers related to reversine inducing cells dedifferentiation and stem cells generation were reviewed.


RESULTS
To obtain stem cells, there are always some disadvantages via somatic cell nuclear transfer or gene transfection. However reversine, a small molecule, can induce cells dedifferentiation which has unique advantage. But its mechanism is still unclear.


CONCLUSIONS
The chemical approach for generation of induced pluripotent stem cells by reversine may take the place of other methods.
Department of Orthopaedics, Second Affiliated Hospital of Wenzhou Medical College, Wenzhou Zhejiang 325000, PR China.
Xuqi
X
Hu
Xiaolei
X
Zhang
Yifei
Y
Zhou
Yang
Y
Yu
Huazi
H
Xu
D053687:Adult Stem Cells / Q000166:cytology*; D000818:Animals; D002450:Cell Communication / Q000187:drug effects; D054337:Cell Dedifferentiation / Q000187:drug effects*; D002454:Cell Differentiation / Q000187:drug effects; D002460:Cell Line; D065150:Cellular Reprogramming / Q000502:physiology; D006801:Humans; D057026:Induced Pluripotent Stem Cells / Q000166:cytology; D009025:Morpholines / Q000494:pharmacology*; D018482:Muscle, Skeletal / Q000166:cytology; D032446:Myoblasts / Q000166:cytology; D053652:Nuclear Transfer Techniques; D039904:Pluripotent Stem Cells / Q000166:cytology*; D011687:Purines / Q000494:pharmacology*
D009025:Morpholines; D011687:Purines; C484369:2-(4-morpholinoanilino)-6-cyclohexylaminopurine