Organosilicon molecules with medicinal applications.
The incorporation of silicon and synthesis of organosilicon small molecules provide unique opportunities for medicinal applications. The biological investigation of organosilicon small molecules is particularly interesting because of differences in their chemical properties that can contribute to enhanced potency and improved pharmacological attributes. Applications such as inhibitor design, imaging, drug release technology, and mapping inhibitor binding are discussed.
Department of Chemistry, University of California-Davis , One Shields Avenue, Davis, California, USA. akfranz@ucdavis.edu
Annaliese K
AK
Franz
Sean O
SO
Wilson
D000596:Amino Acids / Q000737:chemistry; D004355:Drug Stability; D006860:Hydrogen Bonding; D017646:Organosilicon Compounds / Q000008:administration & dosage / Q000494:pharmacology*
D000596:Amino Acids; D017646:Organosilicon Compounds