Topiramate-induced refractory hypokalemia.
Topiramate belongs to the new class of neuromodulators, which has carbonic anhydrase inhibitor activity and been associated with renal calculi. It has also been shown to cause renal potassium wasting; however, it is generally clinically insignificant. Here, we describe a case of refractory hypokalemia in a patient with severe comorbidities who was on topiramate for seizures.
Department of Medicine, Division of Nephrology, St. Luke's-Roosevelt Hospital Center, Columbia University College of Physicians and Surgeons, New York, NY.
Girish N
GN
Nadkarni
Narender
N
Annapureddy
Ira S
IS
Meisels
D002257:Carbonic Anhydrase Inhibitors / Q000009:adverse effects*; D005632:Fructose / Q000009:adverse effects / Q000031:analogs & derivatives*; D006801:Humans; D007008:Hypokalemia / Q000139:chemically induced*; D008297:Male; D008875:Middle Aged; D000077236:Topiramate
D002257:Carbonic Anhydrase Inhibitors; D000077236:Topiramate; D005632:Fructose