Phylogenetic analysis of non-O157 Shiga toxin-producing Escherichia coli strains by whole-genome sequencing.
Non-O157 Shiga toxin-producing Escherichia coli (STEC) strains are emerging food-borne pathogens causing life-threatening diseases and food-borne outbreaks. A better understanding of their evolution provides a framework for developing tools to control food safety. We obtained 15 genomes of non-O157 STEC strains, including O26, O111, and O103 strains. Phylogenetic trees revealed a close relationship between O26:H11 and O111:H11 and a scattered distribution of O111. We hypothesize that STEC serotypes with the same H antigens might share common ancestors.
Department of Nutrition and Food Science and Joint Institute for Food Safety and Applied Nutrition, University of Maryland, College Park, Maryland, USA.
Wenting
W
Ju
Guojie
G
Cao
Lydia
L
Rump
Errol
E
Strain
Yan
Y
Luo
Ruth
R
Timme
Marc
M
Allard
Shaohua
S
Zhao
Eric
E
Brown
Jianghong
J
Meng
D016000:Cluster Analysis; D004927:Escherichia coli Infections / Q000453:epidemiology / Q000382:microbiology; D005517:Foodborne Diseases / Q000453:epidemiology / Q000382:microbiology; D016680:Genome, Bacterial; D006801:Humans; D017720:Molecular Epidemiology; D010802:Phylogeny; D017422:Sequence Analysis, DNA; D017385:Sequence Homology; D054323:Shiga-Toxigenic Escherichia coli / Q000145:classification* / Q000235:genetics*