Serum fetuin-A levels are inversely associated with clinical severity in patients with primary knee osteoarthritis.
The present study aimed to detect serum fetuin-A levels in knee osteoarthritis (OA) patients and to investigate their correlation with clinical severity. We enrolled 215 knee OA patients and 76 healthy controls. We measured serum fetuin-A levels by enzyme-linked immunosorbent assay and assessed the correlation between serum fetuin-A levels and Kellgren-Lawrence grades as well as Western Ontario and McMaster Universities Arthritis Index scores in OA patients. Our results demonstrated that serum fetuin-A levels were independently and negatively correlated with greater clinical severity in OA patients.
Department of Anesthesiology, Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, PR China.
Jie
J
Xiao
Xiang-Rui
XR
Wang
Kong-Zu
KZ
Hu
Mao-Qiang
MQ
Li
Jian-Wei
JW
Chen
Tao
T
Ma
Zhan-Chun
ZC
Li
D000368:Aged; D015415:Biomarkers / Q000097:blood; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D020370:Osteoarthritis, Knee / Q000097:blood*; D012720:Severity of Illness Index; D060749:alpha-2-HS-Glycoprotein / Q000378:metabolism*
D015415:Biomarkers; D060749:alpha-2-HS-Glycoprotein