Dermokine expression in intraductal papillary-mucinous neoplasm and invasive pancreatic carcinoma.
BACKGROUND
Serum dermokine (DK) is a novel biomarker for early colorectal cancer. To our knowledge this is the first study of DK expression in intraductal papillary mucinous neoplasm (IPMN) and pancreatic cancer.


METHODS
DK expression in human pancreatic cancer cell lines and tissues was assessed. We compared the sensitivities of common diagnostic markers, carbohydrate antigen 19-9 (CA19-9), carcinoembryonic antigen (CEA), s-pancreas-1 antigen (SPAN-1), pancreatic cancer-associated antigen (DUPAN-2), and Nation Cancer Center-Stomach-439 (NCC-ST-439) in 26 patients with pancreatic neoplasms.


RESULTS
DK was expressed in pancreatic cancer cell lines. Immunohistochemical staining revealed that DK was expressed in atypical and cancerous tissues, but not in the normal pancreatic tissues. Serum DK was relatively high in patients with IPMN. The sensitivities of a serum multimarker test including DK was 76.5% (n=13/17) for IPMA/IPMC/invasive carcinoma derived from IPMN, and 100% (n=9/9) for ordinary invasive ductal carcinoma.


CONCLUSIONS
Serum DK is a potential biomarker in IPMN and invasive ductal carcinoma, when used in combination with conventional biomarkers.
Department of Surgery, Hyogo College of Medicine, 1-1 Mukogawa-cho, Nishinomiya 663-8501, Japan.
Kenji
K
Watanabe
Toshiya
T
Oochiai
Shojiro
S
Kikuchi
Tatsuya
T
Kumano
Takeshi
T
Matsui
Koji
K
Morimoto
Satoru
S
Yasukawa
Shoji
S
Nakamori
Mitsuru
M
Sasako
Akio
A
Yanagisawa
Eigo
E
Otsuji
D002288:Adenocarcinoma, Mucinous / Q000378:metabolism / Q000473:pathology*; D014408:Biomarkers, Tumor / Q000032:analysis / Q000378:metabolism*; D021441:Carcinoma, Pancreatic Ductal / Q000378:metabolism / Q000473:pathology*; D002291:Carcinoma, Papillary / Q000378:metabolism / Q000473:pathology*; D045744:Cell Line, Tumor; D006801:Humans; D007150:Immunohistochemistry; D036341:Intercellular Signaling Peptides and Proteins; D010190:Pancreatic Neoplasms / Q000378:metabolism / Q000473:pathology*; D011506:Proteins / Q000378:metabolism*
D014408:Biomarkers, Tumor; C495568:DMKN protein, human; D036341:Intercellular Signaling Peptides and Proteins; D011506:Proteins