Jatrophane diterpenoids from the latex of Euphorbia dendroides and their anti-P-glycoprotein activity in human multi-drug resistant cancer cell lines.
Thirteen jatrophane diterpenoids (1-10, 13-15), three previously isolated (11, 12, 16) and a known tigliane (17) were isolated from the latex of Euphorbia dendroides. The structures and relative configurations of compounds were elucidated by spectroscopic techniques. The P-glycoprotein (P-gp) inhibiting activities of the representative set of jatrophanes (1-6 and 11-16) have been assessed. Jatrophanes 2 and 5 demonstrated the most powerful inhibition of P-gp, higher than R(+)-verapamil and tariquidar in colorectal multi-drug resistant (MDR) cells (DLD1-TxR).
Institute of Chemistry, Technology and Metallurgy, Center for Chemistry, University of Belgrade, Belgrade, Serbia.
Milka
M
Jadranin
Milica
M
Pešić
Ivana S
IS
Aljančić
Slobodan M
SM
Milosavljević
Nina M
NM
Todorović
Ana
A
Podolski-Renić
Jasna
J
Banković
Nikola
N
Tanić
Ivanka
I
Marković
Vlatka E
VE
Vajs
Vele V
VV
Tešević
D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1 / Q000037:antagonists & inhibitors*; D000970:Antineoplastic Agents / Q000737:chemistry* / Q000494:pharmacology*; D001060:Aporphines / Q000737:chemistry / Q000494:pharmacology; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D004224:Diterpenes / Q000737:chemistry / Q000494:pharmacology; D019008:Drug Resistance, Neoplasm; D028481:Euphorbia / Q000737:chemistry*; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D011804:Quinolines / Q000737:chemistry / Q000494:pharmacology
D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1; D000970:Antineoplastic Agents; D001060:Aporphines; D004224:Diterpenes; D011804:Quinolines; C081279:aporphine; C402343:tariquidar