Synthesis and cytotoxicity evaluation of highly functionalized pyranochromenes and pyranopyrans.
A series of fluorinated tetrahydropyrano[3,2-c]chromenes and dihydropyrano[3,2-b]pyran derivatives have been synthesized and their in vitro cytotoxic activities have been determined in cervical cancer cell line (HeLa), human breast adenocarcinoma cell line (MDA-MB-231 and MCF-7) and human alveolar adenocarcinoma cell line (A549). Compounds 4g, 4k, 4p showed a very potent activity against MDA-MB-231, and 4c, 4p showed promising activity against MCF-7, while compounds 4c, 4g, 4p showed moderate activity against HeLa.
Crop Protection Chemicals Division, Indian Institute of Chemical Technology, Tarnaka, Hyderabad 500607, India.
Narender Reddy
NR
Emmadi
Krishnaiah
K
Atmakur
Ganesh Kumar
GK
Chityal
Sujitha
S
Pombala
Jagadeesh Babu
JB
Nanubolu
D001578:Benzopyrans / Q000138:chemical synthesis / Q000737:chemistry* / Q000633:toxicity; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D018360:Crystallography, X-Ray; D006367:HeLa Cells; D006801:Humans; D061986:MCF-7 Cells; D008968:Molecular Conformation; D011714:Pyrans / Q000138:chemical synthesis / Q000737:chemistry* / Q000633:toxicity
D001578:Benzopyrans; D011714:Pyrans