Cell(MC3T3-E1)-printed poly(ϵ-caprolactone)/alginate hybrid scaffolds for tissue regeneration.
A new cell-printed scaffold consisting of poly(ϵ-caprolactone) (PCL) and cell-embedded alginate struts is designed. The PCL and alginate struts are stacked in an interdigitated pattern in successive layers to acquire a three-dimensional (3D) shape. The hybrid scaffold exhibits a two-phase structure consisting of cell (MC3T3-E1)-laden alginate struts able to support biological activity and PCL struts able to provide controllable mechanical support of the cell-laden alginate struts. The hybrid scaffolds exhibit an impressive increase in tensile modulus and maximum strength compared to pure alginate scaffolds. Laden cells are homogeneously distributed throughout the alginate struts and the entire scaffold, resulting in cell viability of approximately 84%.
Department of Mechanical Engineering, Chosun University, GwangJu, South Korea.
Hyeongjin
H
Lee
SeungHyun
S
Ahn
Lawrence J
LJ
Bonassar
GeunHyung
G
Kim
D000464:Alginates / Q000737:chemistry* / Q000633:toxicity; D000818:Animals; D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects; D020723:Glucuronic Acid / Q000737:chemistry / Q000633:toxicity; D006603:Hexuronic Acids / Q000737:chemistry / Q000633:toxicity; D020136:Hydrogel, Polyethylene Glycol Dimethacrylate / Q000737:chemistry; D051379:Mice; D011091:Polyesters / Q000737:chemistry* / Q000633:toxicity; D023822:Tissue Engineering; D054457:Tissue Scaffolds
D000464:Alginates; D006603:Hexuronic Acids; D011091:Polyesters; C016240:polycaprolactone; D020136:Hydrogel, Polyethylene Glycol Dimethacrylate; D020723:Glucuronic Acid