Theoretical basis of a beneficial role for vitamin D in viral hepatitis.
Abnormal bone metabolism and dysfunction of the calcium-parathyroid hormone-vitamin D axis have been reported in patients with viral hepatitis. Some studies suggested a relationship between vitamin D and viral hepatitis. Genetic studies have provided an opportunity to identify the proteins that link vitamin D to the pathology of viral hepatitis (i.e., the major histocompatibility complex class II molecules, the vitamin D receptor, cytochrome P₄₅₀, the renin-angiotensin system, apolipoprotein E, liver X receptor, toll-like receptor, and the proteins regulated by the Sp1 promoter gene). Vitamin D also exerts its effects on viral hepatitis via non-genomic factors, i.e., matrix metalloproteinase, endothelial vascular growth factor, prostaglandins, cyclooxygenase-2, and oxidative stress. In conclusion, vitamin D could have a beneficial role in viral hepatitis. Calcitriol is best used for viral hepatitis because it is the active form of the vitamin D₃ metabolite.
Vietnamese American Medical Research Foundation, Westminster, CA 92683, USA. lng2687765@aol.com
Khanh vinh quốc
Kv
Lương
Lan Thi Hoàng
LT
Nguyễn
D015415:Biomarkers / Q000378:metabolism; D002117:Calcitriol / Q000627:therapeutic use*; D006509:Hepatitis B / Q000150:complications / Q000188:drug therapy / Q000235:genetics / Q000378:metabolism*; D006526:Hepatitis C / Q000150:complications / Q000188:drug therapy / Q000235:genetics / Q000378:metabolism*; D006801:Humans; D014807:Vitamin D / Q000031:analogs & derivatives / Q000097:blood / Q000378:metabolism* / Q000627:therapeutic use; D014808:Vitamin D Deficiency / Q000188:drug therapy / Q000378:metabolism / Q000821:virology*; D014815:Vitamins / Q000627:therapeutic use*
D015415:Biomarkers; D014815:Vitamins; D014807:Vitamin D; C104450:25-hydroxyvitamin D; D002117:Calcitriol