Synthesis and antiviral evaluation of alpha-amino acid esters bearing N6-benzyladenine side chain.
A series of peptide derivatives conjugated with a purine residue were synthesized. The prepared compounds were tested for antiviral activity against Hepatitis B Virus (HBV) displaying different degrees of antiviral activities or inhibitory actions.
Department of Applied Chemistry, Faculty of Applied Science, Taibah University, Madinah, Saudi Arabia.
Reem A K
RA
Al-Harbi
Adel A-H
AA
Abdel-Rahman
D000225:Adenine / Q000031:analogs & derivatives* / Q000737:chemistry / Q000494:pharmacology*; D000596:Amino Acids / Q000138:chemical synthesis* / Q000494:pharmacology; D000998:Antiviral Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D004952:Esters / Q000138:chemical synthesis* / Q000494:pharmacology*; D006515:Hepatitis B virus / Q000187:drug effects; D010455:Peptides / Q000138:chemical synthesis / Q000494:pharmacology; D011687:Purines / Q000737:chemistry
D000596:Amino Acids; D000998:Antiviral Agents; D004952:Esters; D010455:Peptides; D011687:Purines; D000225:Adenine; C030985:purine