Azepane quaternary amino acids as effective inducers of 3(10) helix conformations.
A simple method for the synthesis of an azepane quaternary amino acid in enantiopure form is described. Theoretical, NMR, and X-ray studies indicated that this azepane-derived amino acid is an effective stabilizer of 3(10) helical structures in short peptides.
Instituto de Química Médica  (IQM-CSIC), Juan de la Cierva 2, 28006 Madrid, Spain.
Diego
D
Núñez-Villanueva
Lourdes
L
Infantes
M Teresa
MT
García-López
Rosario
R
González-Muñiz
Mercedes
M
Martín-Martínez
D000595:Amino Acid Sequence; D000596:Amino Acids / Q000737:chemistry*; D001381:Azepines / Q000737:chemistry*; D018360:Crystallography, X-Ray; D006860:Hydrogen Bonding; D008968:Molecular Conformation; D019906:Nuclear Magnetic Resonance, Biomolecular; D010455:Peptides / Q000737:chemistry*; D017433:Protein Structure, Secondary
D000596:Amino Acids; D001381:Azepines; D010455:Peptides