Genetic variants of GRIA1 are associated with susceptibility to schizophrenia in Korean population.
The α-amino-3-hydroxy-5-methyl-4-propionic acid (AMPA) receptors are important for glutamate synaptic transmission in the central nervous system. Glutamate receptor, ionotropic, AMPA receptor 1 gene (GRIA1) belongs to the family of AMPA receptors. There is increasing evidence that AMPA receptors dysfunction may be related to an increased susceptibility to schizophrenia. The aim of this study was therefore to investigate whether genetic polymorphisms of GRIA1 are associated with schizophrenia and their clinical symptoms (hallucinations and delusions) in Korean population. Five single nucleotide polymorphisms (rs1428920, rs1552834, rs1422889, rs10035143, and rs2926835) of the GRIA1 were genotyped in 218 schizophrenia patients and 380 healthy controls, using a direct sequencing. All patients were evaluated by the Operational Criteria Checklist for Psychotic Illness. The genotype and allelic frequencies of rs1428920 and rs2926835 showed significant association between schizophrenia and controls (rs1428920, permutation p = 0.008, 0.008; rs2926835, permutation p = 0.038, 0.041, respectively). A significantly increased risk of schizophrenia was associated with the A allele of rs1428920 and rs2926835 of GRIA1. Furthermore, we found that rs1428920 was weakly associated with hallucinations of schizophrenia, but this significance disappeared after multiple testing (permutation p = 0.119). These results suggest that GRIA1 polymorphism may have influence upon the risk of developing schizophrenia.
Department of Neuropsychiatry, School of Medicine, Kyung Hee University, Seoul, 130-701, Republic of Korea.
Won Sub
WS
Kang
Jin Kyung
JK
Park
Su Kang
SK
Kim
Hae Jeong
HJ
Park
Sang Min
SM
Lee
Ji Young
JY
Song
Joo-Ho
JH
Chung
Jong Woo
JW
Kim
D000328:Adult; D044466:Asian People / Q000235:genetics*; D016022:Case-Control Studies; D005787:Gene Frequency; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006212:Hallucinations / Q000150:complications / Q000235:genetics; D006801:Humans; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D018091:Receptors, AMPA / Q000235:genetics*; D056910:Republic of Korea; D012559:Schizophrenia / Q000150:complications / Q000235:genetics*
D018091:Receptors, AMPA