Surveillance pathways rescuing eukaryotic ribosomes lost in translation.
Living cells require the continuous production of proteins by the ribosomes. Any problem enforcing these protein factories to stall during mRNA translation may then have deleterious cellular effects. To minimize these defects, eukaryotic cells have evolved dedicated surveillance pathways: non-stop decay (NSD), no-go decay (NGD) and non-functional 18S-rRNA decay (18S-NRD). Recent studies support a general molecular framework for these surveillance pathways, the mechanisms of which are intimately related to translation termination.
Institut de Biochimie et Biophysique Moléculaire et Cellulaire (IBBMC), Centre National de la Recherche Scientifique (CNRS), UMR8619, Université Paris Sud, Orsay, France. marc.graille@polytechnique.edu
Marc
M
Graille
Bertrand
B
Séraphin
D000818:Animals; D004722:Endoribonucleases / Q000378:metabolism; D005057:Eukaryotic Cells / Q000166:cytology; D006801:Humans; D059365:Nonsense Mediated mRNA Decay; D010443:Peptide Chain Termination, Translational; D010445:Peptide Elongation Factors / Q000378:metabolism; D014176:Protein Biosynthesis; D020871:RNA Stability / Q000235:genetics*; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism*; D012270:Ribosomes / Q000235:genetics / Q000378:metabolism*
D010445:Peptide Elongation Factors; D012333:RNA, Messenger; D004722:Endoribonucleases