Zygote intrafallopian transfer among patients with repeated implantation failure.
OBJECTIVE
To summarize the experience of a single center with laparoscopic zygote intrafallopian transfer (ZIFT) performed exclusively among patients with high-order repeated implantation failure (RIF) following in vitro fertilization-embryo transfer (IVF-ET).


METHODS
A retrospective cohort study was performed at the Edith Wolfson Medical Center, a tertiary referral university hospital located in Holon, Israel. A group of 176 patients with 8.15±3.9 previously failed IVF-ET cycles underwent 280 ZIFT procedures between 1995 and 2010. The main outcome measure was the live birth rate per patient treated.


RESULTS
In all, there were 274 fresh and 6 frozen ZIFT cycles recorded in the study cohort, resulting in 96 clinical pregnancies per attempt (34.3%) and 72 live births (25.7%). The live birth rate per patient was 39.8%.


CONCLUSIONS
The use of ZIFT remains a powerful tool in the clinical management of selected patients with high-order RIF. This procedure should be kept in mind when all other measures fail among patients with at least 1 unobstructed fallopian tube.
IVF Unit, Department of Obstetrics and Gynecology, Edith Wolfson Medical Center, Holon, Israel. a_w@zahav.net.il
Ariel
A
Weissman
Eran
E
Horowitz
Amir
A
Ravhon
Hana
H
Nahum
Abraham
A
Golan
David
D
Levran
D000328:Adult; D015331:Cohort Studies; D015925:Cryopreservation; D010064:Embryo Implantation; D004624:Embryo Transfer / Q000379:methods*; D005260:Female; D005307:Fertilization in Vitro / Q000379:methods*; D006785:Hospitals, University; D006801:Humans; D007557:Israel; D010535:Laparoscopy / Q000379:methods*; D011247:Pregnancy; D018873:Pregnancy Rate; D012189:Retrospective Studies; D017211:Treatment Failure; D017388:Zygote Intrafallopian Transfer / Q000379:methods*