BMI1 expression identifies subtypes of Merkel cell carcinoma.
Merkel cell carcinoma (MCC) is a rare cutaneous neuroendocrine carcinoma. The aims of this study were to investigate the expression of the transcription factors B-lymphoma Moloney murine leukaemia virus insertion (BMI1), myelocytomatosis viral oncogene homologue (c-Myc) and Snail in MCC tumour specimens and to examine the relationship of these markers to Merkel cell polyoma virus (MCV). The study comprised of 133 patients with primary MCC. The expression of BMI1, Snail and c-Myc protein was assessed by immunohistochemistry and compared with clinical parameters, MCV status and patient survival. The presence of MCV was inversely correlated with the expression of BMI1 protein. Tumours expressing BMI1 protein more often presented with lymph node metastases. Snail protein expression was decreased in cases with metastatic dissemination. This study identified two subgroups of MCC: tumours expressing BMI1 but negative for MCV DNA and tumours negative for BMI1 expression but positive for MCV. Importantly, BMI1-positive cases often presented with lymph node metastases. Combined, these results suggest that subtypes of this malignancy exist.
Department of Oral and Maxillofacial Surgery, Helsinki University Central Hospital, Kasarminkatu 11-13, 00029 HUS, Helsinki, Finland. maria.kouzmina@fimnet.fi
Maria
M
Kouzmina
Valtteri
V
Häyry
Junnu
J
Leikola
Caj
C
Haglund
Tom
T
Böhling
Virve
V
Koljonen
Jaana
J
Hagström
D000368:Aged; D015266:Carcinoma, Merkel Cell / Q000378:metabolism* / Q000401:mortality / Q000473:pathology; D004279:DNA, Viral / Q000032:analysis; D005260:Female; D005387:Finland / Q000453:epidemiology; D006801:Humans; D008207:Lymphatic Metastasis; D008297:Male; D059965:Merkel cell polyomavirus / Q000235:genetics; D008875:Middle Aged; D063150:Polycomb Repressive Complex 1 / Q000096:biosynthesis*; D016271:Proto-Oncogene Proteins c-myc / Q000096:biosynthesis; D012878:Skin Neoplasms / Q000378:metabolism* / Q000401:mortality / Q000473:pathology; D000071250:Snail Family Transcription Factors; D014157:Transcription Factors / Q000096:biosynthesis
C069077:BMI1 protein, human; D004279:DNA, Viral; C489427:MYC protein, human; D016271:Proto-Oncogene Proteins c-myc; D000071250:Snail Family Transcription Factors; D014157:Transcription Factors; D063150:Polycomb Repressive Complex 1