Decreased synovial fluid omentin-1 concentrations reflect symptomatic severity in patients with knee osteoarthritis.
The aim of this study was to measure omentin-1 concentrations in serum and synovial fluid (SF) of knee osteoarthritis (OA) patients and to investigate their correlation with patient-reported symptomatic severity. We enrolled 263 knee OA patients and 62 healthy controls. We collected Western Ontario and McMaster Universities Arthritis Index (WOMAC) scores from OA patients and measured omentin-1 concentrations in serum and SF by enzyme-linked immunosorbent assay (ELISA). Our results demonstrated that omentin-1 concentrations in SF but not serum were independently and negatively correlated with self-reported greater pain and physical disability in OA patients. Omentin-1 in SF might serve as a potential biomarker for reflecting the symptomatic severity of OA.
Department of Biomedical Engineering, Faculty of Electronic Information and Electrical Engineering, Dalian University of Technology, Dalian, Liaoning, PR China.
Zhi-Gang
ZG
Li
De-Wei
DW
Zhao
Chong-Jun
CJ
Xia
Tie-Nan
TN
Wang
Yu-Peng
YP
Liu
Yao
Y
Zhang
Ben-Jie
BJ
Wang
D000368:Aged; D016207:Cytokines / Q000097:blood / Q000134:cerebrospinal fluid / Q000378:metabolism*; D005260:Female; D058851:GPI-Linked Proteins / Q000097:blood / Q000134:cerebrospinal fluid / Q000378:metabolism; D006801:Humans; D037102:Lectins / Q000097:blood / Q000134:cerebrospinal fluid / Q000378:metabolism*; D016014:Linear Models; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D020370:Osteoarthritis, Knee / Q000097:blood / Q000134:cerebrospinal fluid / Q000378:metabolism* / Q000473:pathology*; D012720:Severity of Illness Index; D013582:Synovial Fluid / Q000378:metabolism*
D016207:Cytokines; D058851:GPI-Linked Proteins; C432397:ITLN1 protein, human; D037102:Lectins