C-reactive protein, white blood cells, and neutrophils as early predictors of postoperative complications in patients undergoing laparoscopic sleeve gastrectomy.
BACKGROUND
Early detection and treatment of complications after laparoscopic sleeve gastrectomy (LSG) are mandatory. This study aimed to evaluate C-reactive protein (CRP), white blood cell (WBC) count, and neutrophil (NEU) count in relation to the early diagnosis of major surgical complications after LSG.


METHODS
A prospective study of 177 patients who underwent LSG during 2008-2011 was performed. Measurements of WBC, NEU, and CRP performed on postoperative days 0, 1, 3, 5, 7, 9, 11, 13, and 30 were correlated with postoperative surgical complications.


RESULTS
Both WBC and NEU were correlated with leak or abscess on postoperative days 3, 5, 7, 9, and 11, whereas on day 1, only NEU was significantly increased. Elevated CRP was correlated with leak or abscess on all the days (p < 0.001). The parameters measured were not correlated with postoperative bleeding unless leak or abscess coexisted. According to receiver operating characteristic (ROC) analysis, CRP detected leak or abscess with remarkably higher sensitivity and specificity than WBC or NEU on all the days. Moreover, the area under the curve (AUC) of CRP was higher than the AUC of WBC or NEU, suggesting important statistical significance. On day 1, WBC and NEU achieved 77.8 and 78.3 % sensitivity, respectively, and an even lower specificity (68.4 and 52.6 %), whereas a CRP cutoff at 150 mg/l achieved 83.2 % sensitivity and 100 % specificity. On day 3, the sensitivity and specificity of CRP reached 100 % (cutoff level, 200 mg/l), and on day 5, CRP achieved 83.2 % sensitivity and 100 % specificity (cutoff level, 150 mg/l), whereas for WBC and NEU, specificity was high (>92 %), but sensitivity did not exceed 78.2 %.


CONCLUSIONS
Because CRP detected leak or abscess after LSG with remarkably higher sensitivity and specificity than WBC or NEU, CRP seems to be a more accurate market for the early detection of these complications.
First Department of Propaedeutic Surgery, Hippokration Hospital, Athens Medical School Greece, 114 Queen's Sofia Avenue, Pipinou 52, 11251 Athens, Greece.
Konstantinos
K
Albanopoulos
Leonidas
L
Alevizos
Maria
M
Natoudi
Dimitrios
D
Dardamanis
Evangelos
E
Menenakos
Konstantinos
K
Stamou
George
G
Zografos
Emmanuel
E
Leandros
D018784:Abdominal Abscess / Q000175:diagnosis; D000293:Adolescent; D000328:Adult; D057868:Anastomotic Leak / Q000175:diagnosis; D002097:C-Reactive Protein / Q000378:metabolism*; D042241:Early Diagnosis; D005260:Female; D005743:Gastrectomy / Q000379:methods*; D006801:Humans; D010535:Laparoscopy / Q000379:methods*; D007958:Leukocyte Count; D007962:Leukocytes / Q000502:physiology*; D008297:Male; D008875:Middle Aged; D009504:Neutrophils / Q000502:physiology*; D009767:Obesity, Morbid / Q000601:surgery*; D011183:Postoperative Complications / Q000175:diagnosis*; D011446:Prospective Studies; D055815:Young Adult
D002097:C-Reactive Protein