[Industry-funded therapy studies: what is in the pipeline?].
Several  acute stroke trials are underway or have been recently completed. Among the latter are the ICTUS trial and the IST-3 trial. Several other approaches are being tested for thrombolytic therapy among them modern imaging-based patient selection and new thrombolytic agents, such as desmoteplase and tenecteplase. Other strategies include neuroprotection and neurorestoration, biophysical approaches, such as near infrared laser therapy, hemodynamic augmentation and sphenopalatine ganglion stimulation. Mechanical thrombectomy is practiced in many centers although randomized trials are pending and the IMS-3 trial was stopped. This overview will cover the very recently completed and currently recruiting acute ischemic stroke trials.
Neurologische Klinik und Neurogeriatrie, Johannes Wesling Klinikum Minden, Hans-Nolte-Str. 1, 32429 Minden, Deutschland. peter.schellinger@muehlenkreiskliniken.de
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D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002545:Brain Ischemia / Q000150:complications / Q000191:economics* / Q000628:therapy*; D002986:Clinical Trials as Topic / Q000191:economics*; D005260:Female; D005858:Germany; D017048:Health Care Costs; D019981:Health Care Sector / Q000191:economics*; D006801:Humans; D007036:Hypothermia, Induced / Q000191:economics / Q000379:methods*; D008297:Male; D008875:Middle Aged; D020521:Stroke / Q000191:economics* / Q000209:etiology / Q000628:therapy*; D055815:Young Adult