Turning on brown fat and muscle metabolism: hedging your bets.
Developmental genes are essential in the formation and function of adipose tissue and muscle. In this issue of Cell, Teperino et al. demonstrate that noncanonical hedgehog signaling increases glucose uptake into brown fat and muscle. Modulation of developmental pathways may serve as a potential target for new treatments of diabetes and other metabolic disorders.
Joslin Diabetes Center and Harvard Medical School, Boston, MA 02115, USA.
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