Case report: detection of a hepatitis B surface antigen variant emerging in an elderly patient after an ischemic cerebral vascular accident.
HBV reactivations are observed frequently in patients with past hepatitis B infection receiving cytotoxic and/or immunosuppressive chemotherapy for hemato-oncological malignancies or autoimmune diseases. Recent ischemic stroke was shown to induce immunodepression by misunderstood mechanisms. To our knowledge, the association between HBV reactivation and ischemic stroke has not been reported before. This study reports the case of an anti-HBs- and anti-HBc-positive patient who presented HBV reactivation in a context of recent ischemic stroke, with no other intercurrent iatrogenic phenomenon or usual immunosuppressive pathology.
Virology Laboratory / UMI 3265 UJF-EMBL-CNRS, CHU Grenoble, Michallon Hospital, BP 217, 38043 Grenoble Cedex 9, France.
Alban
A
Deroux
Sylvie
S
Larrat
Marie-Noelle
MN
Hilleret
Monique
M
Baccard
Wen
W
Qin
Gaelle
G
Billet
Philippe
P
Zaoui
Patrice
P
Morand
D000369:Aged, 80 and over; D000595:Amino Acid Sequence; D019943:Amino Acid Substitution; D002545:Brain Ischemia / Q000473:pathology*; D004279:DNA, Viral / Q000235:genetics; D006509:Hepatitis B / Q000175:diagnosis* / Q000821:virology; D006514:Hepatitis B Surface Antigens / Q000097:blood*; D006515:Hepatitis B virus / Q000235:genetics / Q000302:isolation & purification*; D006801:Humans; D008099:Liver / Q000473:pathology / Q000821:virology; D008297:Male; D008969:Molecular Sequence Data; D014775:Virus Activation
D004279:DNA, Viral; D006514:Hepatitis B Surface Antigens