Pathophysiology of the aging kidney and therapeutic interventions.
Kidneys are among the organs affected by the aging process. Aging kidneys are characterized by progressive scarring and measurable declines in renal function. Deficiencies in renal function are associated with mortality in all populations. Therefore, if the kidneys age at an accelerated rate relative to the other organs in a particular individual, then slowing or reversing the kidney aging process may be a therapeutically useful strategy. In this review, we will discuss the physiology and pathogenesis of kidney aging and analyze potential therapeutic strategies for halting the aging process in the kidneys.
Division of Diabetology and Endocrinology, Kanazawa Medical University, Kahoku, Japan.
Keizo
K
Kanasaki
Munehiro
M
Kitada
Daisuke
D
Koya
D000375:Aging / Q000502:physiology*; D000818:Animals; D031204:Caloric Restriction; D004921:Erythropoietin / Q000096:biosynthesis; D005355:Fibrosis; D005966:Glucuronidase / Q000235:genetics; D006801:Humans; D007328:Insulin / Q000378:metabolism; D000078790:Insulin Secretion; D007668:Kidney / Q000473:pathology / Q000502:physiology*; D000090265:Klotho Proteins; D009399:Nephrons / Q000502:physiology; D015398:Signal Transduction; D056564:Sirtuin 1 / Q000502:physiology; D014807:Vitamin D / Q000031:analogs & derivatives / Q000097:blood
D007328:Insulin; D004921:Erythropoietin; D014807:Vitamin D; C097949:1,25-dihydroxyvitamin D; D005966:Glucuronidase; D000090265:Klotho Proteins; C447939:SIRT1 protein, human; D056564:Sirtuin 1