Facile synthesis of dispirooxindole-fused heterocycles via domino 1,4-dipolar addition and Diels-Alder reaction of in situ generated Huisgen 1,4-dipoles.
A facile synthetic protocol was developed for the efficient synthesis of complex dispirooxindole-fused heterocycles via a three-component reaction. The key strategies involve a domino 1,4-dipolar addition and Diels-Alder reaction of the in situ generated Huisgen 1,4-dipoles from the addition reaction of 4-dimethylaminopyridine with acetylenedicarboxylate to 3-phenacylideneoxindole.
College of Chemistry & Chemical Engineering, Yangzhou University, Yangzhou 225002, China.
Jing
J
Sun
Yan
Y
Sun
Hui
H
Gong
Ya-Jing
YJ
Xie
Chao-Guo
CG
Yan
D007211:Indoles / Q000138:chemical synthesis*; D008958:Models, Molecular; D015394:Molecular Structure; D000078183:Oxindoles; D013141:Spiro Compounds / Q000138:chemical synthesis*
D007211:Indoles; D000078183:Oxindoles; D013141:Spiro Compounds; C022960:2-oxindole