ITP in children: pathophysiology and current treatment approaches.
Primary immune thrombocytopenia (ITP) is one of the most common bleeding disorders of childhood. In most cases, it presents with sudden widespread bruising and petechiae in an otherwise well child. Thought to be mainly a disorder of antibody-mediated platelet destruction, ITP can be self-limited or develop into a chronic condition. In this review, we discuss current concepts of the pathophysiology and treatment approaches to pediatric ITP.
Department of Pediatrics, Division of Hematology-Oncology and The Markey Cancer Center, University of Kentucky College of Medicine, Lexington, KY 40536-0096, USA. jdorazio@uky.edu
John A
JA
D'Orazio
Jessica
J
Neely
Nina
N
Farhoudi
D002648:Child; D006801:Humans; D016553:Purpura, Thrombocytopenic, Idiopathic / Q000503:physiopathology* / Q000628:therapy*