Endoplasmic reticulum stress and hypertension - a new paradigm?
Hypertension occurs in approximately 30% of individuals in Western populations and is known to be a major cause of stroke, heart failure, and myocardial infarction. Despite this, the molecular etiology of hypertension remains poorly understood. In this issue of the JCI, Young et al. show that endoplasmic reticulum (ER) stress is an essential signaling event for angiotensin II-induced hypertension in cells of the central nervous system. This provides new insight into the molecular mechanisms that drive hypertension and suggests a potential target for future therapy.
Department of Molecular Physiology and Biophysics and Division of Clinical Pharmacology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232-6602, USA.
Alyssa H
AH
Hasty
David G
DG
Harrison
D000804:Angiotensin II / Q000009:adverse effects*; D000818:Animals; D001921:Brain / Q000378:metabolism*; D059865:Endoplasmic Reticulum Stress; D006973:Hypertension / Q000378:metabolism*; D014662:Vasoconstrictor Agents / Q000009:adverse effects*
D014662:Vasoconstrictor Agents; D000804:Angiotensin II