[Adaptation processes in mice during chronic combined exposure to radiation and chemical compounds (acetone, ethanol, acetaldehyde) innate to exploration missions].
The paper reports the results of experimental investigation with mice subjected to 63-day of daily 10-fold fractionated gamma-irradiation at the total dose of 350 cGy followed by 70-day exposure to chemical mixture (acetone, ethanol, acetate aldehyde) at close to maximum permissible concentrations innate to piloted space vehicles (MPCpsv). Measured levels of radiation and known radiation sensitivity of mice were used to model absorbed dose to cosmonauts on an exploration mission. Functional shifts in the hematopoietic system and changes in biochemical parameters of erythrocytes indicative of energy exchange and redox potential were tracked up during the combined radiation-chemical exposure and 90 days of recovery. It was shown that adaptation caused pronounced and strongly pronounced tension of regulatory mechanisms, particularly under the effects of radiation. High tension still persisted in the recovery period.
S V
SV
Tatarkin
A V
AV
Shafirkin
L N
LN
Mukhamedieva
M Iu
MIu
Barantseva
S M
SM
Ivanova
D000079:Acetaldehyde / Q000633:toxicity; D000096:Acetone / Q000633:toxicity; D000222:Adaptation, Physiological / Q000187:drug effects / Q000528:radiation effects*; D000818:Animals; D018480:Astronauts; D004307:Dose-Response Relationship, Radiation; D004912:Erythrocytes / Q000187:drug effects / Q000528:radiation effects*; D000431:Ethanol / Q000633:toxicity; D005720:Gamma Rays / Q000009:adverse effects*; D006413:Hematopoietic System / Q000187:drug effects / Q000528:radiation effects*; D006801:Humans; D019570:Inhalation Exposure; D008297:Male; D051379:Mice; D008954:Models, Biological; D011829:Radiation Dosage; D011836:Radiation Tolerance; D011874:Radiometry; D013026:Space Flight
D000096:Acetone; D000431:Ethanol; D000079:Acetaldehyde