Association of MUC6-minisatellite variants with susceptibility to rectal carcinoma.
A secreted MUC6 mucin is reported to be expressed highly in the stomach and gall bladder. In previous our study, the five minisatellites were identified and a significant association between MUC6-MS5 alleles and gastric cancer was reported. Because of aberrant MUC6 expression is often found in gastrointestinal diseases, we evaluated a relationship between MUC6-MS5 and susceptibility to colorectal cancers. Case-control study was performed with 1,103 cancer-free controls and 414 rectal cancer cases. A significant association (OR = 2.70) between short rare MUC6-MS5 alleles (7, 9 repeats) and the occurrence of cancer was observed in rectal cancer [95 % confidence interval (CI), 1.12-6.54; p = 0.022]. Furthermore, a comparison by gender showed the differences in the association ratios between rectal cancer and short rare MUC6-MS5 alleles: male, 3.97 (CI: 1.36-11.5; p = 0.006) versus female 0.91 (CI: 0.18-4.75; p = 0.913). We also examined the association according to lymphovascular invasion (LVI). The frequency of LVI positive rectal cancer was increased in short rare allele cases than in the total rectal cases: 16.2 % versus 42.9 %. Therefore, we suggest that the short rare MUC6-MS5 alleles may be related to cancer development in male and these cancer cases may be related the bad prognosis.
Department of Biological Science, Dong-A University, 840 Hadan-2-dong, Saha-gu, Busan 604-714, Korea.
Myoung-Hyun
MH
Ahn
Ki Beom
KB
Bae
Jeong-Ah
JA
Kwon
Hong-Jo
HJ
Choi
Se-Ra
SR
Lee
Si-Hoon
SH
Kim
Tae Doo
TD
Jung
Sun Hee
SH
Kim
Min Sung
MS
An
Kwan Hee
KH
Hong
Jeonghoon
J
Heo
Tae-Hong
TH
Kang
Jin Woong
JW
Chung
Sun-Hee
SH
Leem
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000483:Alleles; D002277:Carcinoma / Q000235:genetics*; D016022:Case-Control Studies; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D018598:Minisatellite Repeats; D055272:Mucin-6 / Q000235:genetics*; D011110:Polymorphism, Genetic; D012004:Rectal Neoplasms / Q000235:genetics*; D012737:Sex Factors
D055272:Mucin-6