Premedication with peppermint oil capsules in colonoscopy: a double blind placebo-controlled randomized trial study.
BACKGROUND
Colonic spasm is an important problem in colonoscopy for endoscopists to advance the colonoscope and visualize the mucosa.


OBJECTIVE
In the present study, we evaluated the efficacy of enteric-coated peppermint oil capsules (Colpermin) as an orally administered antispasmodic premedication in colonoscopy.


METHODS
Sixty-five adult patients undergoing colonoscopy were randomized to receive either Colpermin (n = 33) or placebo capsules (n = 32) as premedication, 4 hours before the procedure. An experienced endoscopist performed colonoscopy. Outcome measures included cecal intubation and total procedure time, spasm score, pain score, endoscopist satisfaction and patients' willingness to repeat colonoscopy.


RESULTS
Duration of both total procedure time and cecal intubation time in patients in the Colpermin group were shorter than that in ones in the placebo group. Scores for colonic spasm and pain were significantly lower in the Colpermin group. The endoscopist satisfaction score was higher in the Colpermin group and patients in the Colpermin group were more willing to repeat colonoscopy in the future.


CONCLUSIONS
Premedication with Colpermin was beneficial in terms of the time required for cecal intubation and total procedure time, reducing colonic spasm, increasing endoscopist satisfaction and decreasing pain in patients during colonoscopy.
Division of Gastroenterology, Department of Internal Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.
A
A
Shavakhi
S K
SK
Ardestani
M
M
Taki
M
M
Goli
A H
AH
Keshteli
D000293:Adolescent; D000328:Adult; D000368:Aged; D002214:Capsules; D003113:Colonoscopy; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D008297:Male; D036142:Mentha piperita; D009822:Oils, Volatile / Q000008:administration & dosage*; D010147:Pain Measurement; D010149:Postoperative Pain / Q000517:prevention & control; D010276:Parasympatholytics / Q000008:administration & dosage*; D010938:Plant Oils / Q000008:administration & dosage*; D011292:Premedication; D011446:Prospective Studies
D002214:Capsules; D009822:Oils, Volatile; D010276:Parasympatholytics; D010938:Plant Oils; C015424:peppermint oil