Halogenation of primary alcohols using a tetraethylammonium halide/[Et2NSF2]BF4 combination.
The halogenation of primary alcohols is presented. The use of a combination of tetraethylammonium halide and [Et(2)NSF(2)]BF(4) (XtalFluor-E) allows for chlorination and bromination reactions to proceed efficiently (up to 92% yield) with a wide range of alcohols. Iodination reactions are also possible albeit in lower yields.
Canada Research Chair in Organic and Medicinal Chemistry, Département de Chimie, Université Laval, 1045 avenue de la Médecine, Québec, QC, Canada G1V 0A6.
Marie-France
MF
Pouliot
Olivier
O
Mahé
Jean-Denys
JD
Hamel
Justine
J
Desroches
Jean-François
JF
Paquin