Innate immune activation in obesity.
The innate immune system is a prewired set of cellular and humoral components that has developed to sense perturbations in normal physiology and trigger responses to restore the system back to baseline. It is now understood that many of these components can also sense the physiologic changes that occur with obesity and be activated. While the exact reasons for this chronic immune response to obesity are unclear, there is strong evidence to suggest that innate inflammatory systems link obesity and disease. Based on this, anti-inflammatory therapies for diseases like type 2 diabetes and metabolic syndrome may form the core of future treatment plans. This review will highlight the components involved in the innate immune response and discuss the evidence that they contribute to the pathogenesis of obesity-associated diseases.
Department of Pediatrics and Communicable Diseases, University of Michigan Medical School, Ann Arbor, MI, United States. clumeng@umich.ed
Carey N
CN
Lumeng
D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D003924:Diabetes Mellitus, Type 2 / Q000150:complications / Q000188:drug therapy / Q000276:immunology; D005234:Fatty Liver / Q000150:complications / Q000188:drug therapy / Q000276:immunology; D006801:Humans; D007113:Immunity, Innate; D007249:Inflammation / Q000188:drug therapy / Q000276:immunology; D024821:Metabolic Syndrome / Q000150:complications / Q000188:drug therapy / Q000276:immunology; D065626:Non-alcoholic Fatty Liver Disease; D009765:Obesity / Q000150:complications / Q000188:drug therapy / Q000276:immunology*
D000893:Anti-Inflammatory Agents