Solophenols B-D and solomonin: new prenylated polyphenols isolated from propolis collected from the Solomon Islands and their antibacterial activity.
Three new prenylated flavonoids, namely, solophenols B (1), C (2), and D (3), as well as a new prenylated stilbene, solomonin (4), were isolated from propolis collected from the Solomon Islands. In addition, 17 known compounds were identified. The structures of the new compounds were determined by a combination of methods, including mass spectrometry and NMR. These new compounds and several known compounds were tested for antibacterial activity against Staphylococcus aureus, Bacillus subtilis, and Pseudomonas aeruginosa. Most of them exhibited potent antibacterial activity. These findings may indicate that propolis from the Solomon Islands has potential applications as an ingredient in food additives or pharmaceuticals.
Department of Food and Nutritional Sciences, University of Shizuoka, 52-1 Yada, Suruga-ku, Shizuoka 422-8526, Japan.
Saori
S
Inui
Takahiro
T
Hosoya
Yuko
Y
Shimamura
Shuichi
S
Masuda
Takeshi
T
Ogawa
Hirokazu
H
Kobayashi
Kenichi
K
Shirafuji
Reuben Toli
RT
Moli
Ikuko
I
Kozone
Kazuo
K
Shin-ya
Shigenori
S
Kumazawa
D000900:Anti-Bacterial Agents; D001412:Bacillus subtilis / Q000187:drug effects; D008542:Melanesia; D015394:Molecular Structure; D059808:Polyphenols / Q000737:chemistry* / Q000494:pharmacology; D054876:Prenylation; D011429:Propolis / Q000737:chemistry*; D011550:Pseudomonas aeruginosa / Q000187:drug effects; D013211:Staphylococcus aureus / Q000187:drug effects
D000900:Anti-Bacterial Agents; D059808:Polyphenols; C578059:solomonin; C578056:solophenol B; C578058:solophenol C; C578057:solophenol D; D011429:Propolis