Family-based association study in Tunisian familial psoriasis.
BACKGROUND
The pathogenesis of all forms of psoriasis remains obscure. Segregation analysis and twin studies together with ethnic differences in disease frequency all point to an underlying genetic susceptibility to psoriasis, which is both complex and likely to reflect the action of a number of genes.


METHODS
In the present study, we performed a family-based association study, and a transmission dysequilibrium test using the PLINK program, in a set of seven Tunisian multiplex families using a panel of 96 single-nucleotide polymorphisms localized in several regions across the genome. Ninety-five of them were reported to be associated with psoriasis in different populations.


RESULTS
Besides the confirmation of association between previous associated regions: 6p, 1p, 2p, 13q, 14q, and 20p, and cutaneous psoriasis, we identified a new association with the rs1249564 in the IL17RD gene.


CONCLUSIONS
Our results support the complex genetic basis of psoriasis.
Laboratory of Genetic, Immunology and Human Pathologies, Department of Biology, Faculty of Sciences, Tunis, Tunisia. myriambensaid@yahoo.fr
Myriam
M
Ammar
Chiraz
C
Bouchlaka-Souissi
Ines
I
Zaraa
Cindy
C
Helms
Nejib
N
Doss
Fatma
F
Bouazizi
Raouf
R
Dhaoui
Amel Ben
AB
Ossman
Amel Ben
AB
Ammar-el Gaied
Mourad
M
Mokni
D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D055106:Genome-Wide Association Study; D006801:Humans; D008875:Middle Aged; D011565:Psoriasis / Q000235:genetics*; D014416:Tunisia; D055815:Young Adult