In vivo antimalarial activity of Ajuga remota water extracts against Plasmodium berghei in mice.
We investigated the in vivo activity of crude water extracts of Ajuga remota Benth (Labiatae) against Plasmodium berghei in mice using plants harvested from two areas in Kenya where the plant is commonly used to treat malaria. The extract was tested using a 4-day test at a dose of 30 mg/kg/day (equivalent to 0.2 ml solution per mouse). Wet leaf extract was the most effective with 90.4% suppression of parasitemia. Extract from air-dried and powdered flowers were the least effective with 17.2% suppression of parasitemia.
Department of Chemistry, Drake University, Des Moines, IA 50325, USA. John.Gitua@drake.edu
John N
JN
Gitua
Daniel R
DR
Muchiri
Xuan-An T
XA
Nguyen
D031328:Ajuga; D000818:Animals; D000962:Antimalarials / Q000494:pharmacology* / Q000627:therapeutic use; D007630:Kenya; D016778:Malaria, Falciparum / Q000188:drug therapy*; D051379:Mice; D010936:Plant Extracts / Q000494:pharmacology* / Q000627:therapeutic use; D010962:Plasmodium berghei / Q000187:drug effects*; D011529:Protozoan Infections, Animal / Q000188:drug therapy*
D000962:Antimalarials; D010936:Plant Extracts