Optical coherence tomography and ultrasound biomicroscopy imaging of opaque corneas.
OBJECTIVE
The purpose was to determine the interchangeability of ultrasound biomicroscopy (UBM) and anterior segment optical coherence tomography (AS-OCT) for corneal opacity depth measurement.


METHODS
Twenty-six eyes of 26 consecutive patients with corneal opacities were examined by both AS-OCT and UBM. The corneal thickness and the corneal opacity depth were measured and compared. The interchangeability was determined by Bland-Altman plotting.


RESULTS
The difference in the full corneal thickness and in the corneal opacity depth between OCT and UBM was 5 ± 7 μm and -1 ± 8 μm, respectively. There were strong correlations and no significant differences between the paired parameters (all r > 0.99, P < 0.01). The limits of agreement were 5 ± 14 μm for the corneal thickness and -1 ± 14.8 μm for the corneal opacity depth.


CONCLUSIONS
AS-OCT and UBM may be used interchangeably for measuring both full corneal thickness and corneal opacity depth in patients with corneal opacity.
Corneal Division, Zhongshan Ophthalmic Center at Sun Yat-sen University, The State Key Laboratory of Ophthalmology, Guangzhou, China.
Shi-you
SY
Zhou
Chun-xiao
CX
Wang
Xiao-yu
XY
Cai
David
D
Huang
Yi-zhi
YZ
Liu
D000293:Adolescent; D000328:Adult; D000368:Aged; D003318:Corneal Opacity / Q000175:diagnosis*; D003319:Corneal Stroma / Q000473:pathology; D005260:Female; D006801:Humans; D008297:Male; D033401:Microscopy, Acoustic; D008875:Middle Aged; D011446:Prospective Studies; D015203:Reproducibility of Results; D041623:Tomography, Optical Coherence; D055815:Young Adult