[Primary study of joint estrogenic activity of Cd2+, Pb2+, parathion and dimethoate].
OBJECTIVE
To study joint estrogenic activity of Cd2+, Pb2+, parathion and dimethoate in immature female mice.


METHODS
192 17 day-age immature female mice of ablactation were divided randomly by body weight (25g +/- 2g) into 16 groups by intraperitoneal injection at the dose of 0, 1/20LD50, 1/50LD50, 1/100LD50 Cd2+, 1/ 20LD50, 1/50LD50, 1/100LD50 Pb2+, 1/20LD50, 1/50LD50, 1/100LD50 Parathion, 1/ 20LD50, 1/50LD50, 1/100LD52 Dimethoate and 1/20LD50, 1/50LD50, 1/100LD50 Cd2+ + Pb2+ + Parathion + Dimethoat per day for 3 consecutive days. Uteruses wet weight, endometrial cells and ER were measured.


RESULTS
Compared with the control group, 1/ 50LD50 Cd2+, 1/50LD50 Pb2+ and 1/100LD50 Cd2+ + Pb2+ + Parathion + Dimethoate significantly changed uteruses wet weight, 1/20LD50, 1/50LD50, 1/100LD50 Cd2+, 1/ 20LD50 Pb2+, and 1/20LD50, 1/50LD50 Cd2+ + Pb2+ + Parathion + Dimethoate significantly increased endometrial cells, all treated groups' ER were significantly increased except for 1/20LD50 and 1/50LD50 Cd2+ and 1/20LD50 Parathion.


CONCLUSIONS
There are significant difference between singal factor and joint activity, IN joint activity, Addition effect, synergism and antagonism occurred in different treated groups and different index.
State Key Laboratory of Space Medicine Fundamentals and Application, China Astronaut Research and Training Center, 10094 Beijing China.
Shujing
S
Zhang
Yanbo
Y
Yu
Peng
P
Zang
Bin
B
Chen
D000818:Animals; D002104:Cadmium / Q000633:toxicity*; D004117:Dimethoate / Q000633:toxicity*; D004347:Drug Interactions; D004717:Endometrium / Q000166:cytology / Q000187:drug effects; D005260:Female; D051379:Mice; D009929:Organ Size; D010278:Parathion / Q000633:toxicity*; D014599:Uterus / Q000187:drug effects*
D002104:Cadmium; D010278:Parathion; D004117:Dimethoate