Antidyslipidemic and antioxidant activity of the constituents isolated from the leaves of Calophyllum inophyllum.
In continuation of our drug discovery program on Indian medicinal plants, we isolated bioactive compounds (1-5) from the leaves of Calophyllum inophyllum and evaluated their antidyslipidemic activity in triton induced hyperlipidemia model. The calophyllic acid (1A) and isocalophyllic acid (1B) mixture, canophyllic acid (4) and amentoflavone (5) showed dose dependent lipid lowering activity in in vivo experiments. The compounds 1A+1B mixture and 3 also showed good in vitro antioxidant activity.
Medicinal and Process Chemistry Division, CSIR-Central Drug Research Institute, U.P., India.
Janki
J
Prasad
Atul
A
Shrivastava
A K
AK
Khanna
G
G
Bhatia
S K
SK
Awasthi
T
T
Narender
D000818:Animals; D000975:Antioxidants / Q000302:isolation & purification / Q000494:pharmacology / Q000627:therapeutic use*; D044946:Biflavonoids / Q000302:isolation & purification / Q000494:pharmacology / Q000627:therapeutic use*; D029759:Calophyllum / Q000737:chemistry*; D002867:Chromones / Q000302:isolation & purification / Q000494:pharmacology / Q000627:therapeutic use*; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D047309:Flavones / Q000302:isolation & purification / Q000494:pharmacology / Q000627:therapeutic use*; D006949:Hyperlipidemias / Q000097:blood / Q000188:drug therapy*; D000960:Hypolipidemic Agents / Q000302:isolation & purification / Q000494:pharmacology / Q000627:therapeutic use*; D008055:Lipids / Q000097:blood; D018541:Neptune; D008517:Phytotherapy; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use*; D018515:Plant Leaves / Q000737:chemistry; D051381:Rats; D014315:Triterpenes / Q000494:pharmacology
D000975:Antioxidants; D044946:Biflavonoids; D002867:Chromones; D047309:Flavones; D000960:Hypolipidemic Agents; D008055:Lipids; D010936:Plant Extracts; D014315:Triterpenes; C580626:calophyllic acid; C580627:canophyllic acid; C011164:amentoflavone