[Systemic metabolic pathogenetic factors of affection of the solitary kidney in males (a pilot trial)].
Our pilot trial demonstrates high prevalence of solitary kidney (SK) diseases in men (82.7%). Present-day SK diseases are often accompanied with marked systemic metabolic disorders (obesity, dyslipidemia, androgen deficiency). We found correlations between obesity and incidence of acid urine urolithiasis of the SK, between type II diabetes mellitus, obesity and SK cystic disease. SK men's glomerular filtration rate depends on the level of total testosterone in blood. We believe that early detection and pathogenetic correction of dyslipidemia, obesity and androgen deficiency in SK men may be key prophylactic factors of SK diseases which often entail development of chronic renal failure.
I A
IA
Tiuzikov
A G
AG
Martov
D000368:Aged; D000369:Aged, 80 and over; D000728:Androgens; D003924:Diabetes Mellitus, Type 2 / Q000378:metabolism / Q000473:pathology / Q000503:physiopathology; D003928:Diabetic Nephropathies / Q000378:metabolism / Q000473:pathology / Q000503:physiopathology; D005260:Female; D005919:Glomerular Filtration Rate; D006801:Humans; D007668:Kidney / Q000378:metabolism* / Q000473:pathology / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D009392:Nephrectomy; D053040:Nephrolithiasis / Q000209:etiology / Q000378:metabolism* / Q000473:pathology / Q000503:physiopathology*; D009765:Obesity / Q000150:complications / Q000378:metabolism / Q000473:pathology / Q000503:physiopathology; D010865:Pilot Projects
D000728:Androgens