A zwitterionic squaraine dye with a large Stokes shift for in vivo and site-selective protein sensing.
A novel squaraine dye (SQ) exhibits improved fluorescence response toward protein detection by incorporation of a zwitterionic structure. With the aid of a dansylamide (DNSA) substituent, the new probe (DNSA-SQ) exhibits remarkable selectivity in binding to site I (a specific substructure in protein).
Department of Chemistry & Maurice Morton Institute of Polymer Science, The University of Akron, Akron, OH 44325, USA.
Yongqian
Y
Xu
Qin
Q
Liu
Xiaopeng
X
Li
Chrys
C
Wesdemiotis
Yi
Y
Pang
D000818:Animals; D002417:Cattle; D003503:Cyclobutanes / Q000138:chemical synthesis / Q000737:chemistry*; D003619:Dansyl Compounds / Q000737:chemistry; D005456:Fluorescent Dyes / Q000737:chemistry*; D010636:Phenols / Q000138:chemical synthesis / Q000737:chemistry*; D011485:Protein Binding; D012710:Serum Albumin, Bovine / Q000032:analysis*; D013050:Spectrometry, Fluorescence; D015027:Zebrafish / Q000378:metabolism
D003503:Cyclobutanes; D003619:Dansyl Compounds; D005456:Fluorescent Dyes; D010636:Phenols; C480596:squaraine; C001026:5-dimethylaminonaphthalene-1-sulfonamide; D012710:Serum Albumin, Bovine