Antiviral chromones from the stem of Cassia siamea.
Seven new chromones, siamchromones A-G (1-7), and 12 known chromones (8-19) were isolated from the stems of Cassia siamea. Compounds 1-19 were evaluated for their antitobacco mosaic virus (anti-TMV) and anti-HIV-1 activities. Compound 6 showed antitobacco mosaic virus (anti-TMV) activity with an inhibition rate of 35.3% and IC50 value of 31.2 μM, which is higher than that of the positive control, ningnamycin. Compounds 1, 10, 13, and 16 showed anti-TMV activities with inhibition rates above 10%. Compounds 4, 6, 13, and 19 showed anti-HIV-1 activities with therapeutic index values above 50.
Key Laboratory of Chemistry in Ethnic Medicinal Resources, State Ethnic Affairs Commission & Ministry of Education, Yunnan University of Nationalities , Kunming 650031, Yunnan, People's Republic of China.
Qiu-Fen
QF
Hu
Bin
B
Zhou
Xue-Mei
XM
Gao
Li-Ying
LY
Yang
Li-Dan
LD
Shu
Yanqiong
Y
Shen
Gan-Peng
GP
Li
Chun-Tao
CT
Che
Guang-Yu
GY
Yang
D000998:Antiviral Agents / Q000494:pharmacology*; D002366:Cassia / Q000737:chemistry*; D002867:Chromones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D015497:HIV-1 / Q000187:drug effects*; D015394:Molecular Structure; D018547:Plant Stems / Q000737:chemistry; D014027:Tobacco Mosaic Virus / Q000187:drug effects*
C587741:5-hydoxy-2-(3-hydroxypropyl)-8,8-dimethylpyrano(2,3-f)chromen-4(8H)-one; D000998:Antiviral Agents; D002867:Chromones; D004365:Drugs, Chinese Herbal