Recurrent rhabdomyosarcoma after adjuvant chemotherapy for stage I non-seminomatous germ cell tumor with malignant transformation.
We report a rare case of stage I non-seminomatous testicular germ cell tumor with malignant transformation. The patient received two cycles of chemotherapy (cisplatin, bleomycin and etoposide) tailored to testicular germ cell tumors as an adjuvant therapy after orchiectomy. However, 22 months later, the patient developed a metastasis in the occipital region that consisted of solely rhabdomyosarcoma through malignant transformation of a teratoma component. This case highlights an issue related to adjuvant chemotherapy for testicular germ cell tumors with components of malignant transformation.
Department of Urology, Shiga University of Medical Science, Otsu, Shiga, Japan.
Hiroshi
H
Ushida
Shuichi
S
Koizumi
Kenjiro
K
Katoh
Hidetoshi
H
Okabe
Yusaku
Y
Okada
Keisei
K
Okamoto
D000328:Adult; D000970:Antineoplastic Agents / Q000627:therapeutic use; D001932:Brain Neoplasms / Q000188:drug therapy / Q000556:secondary*; D017024:Chemotherapy, Adjuvant; D017809:Fatal Outcome; D006801:Humans; D008297:Male; D009373:Neoplasms, Germ Cell and Embryonal / Q000188:drug therapy / Q000473:pathology*; D009777:Occipital Bone / Q000473:pathology*; D012208:Rhabdomyosarcoma / Q000188:drug therapy / Q000556:secondary*; D012888:Skull Neoplasms / Q000188:drug therapy / Q000556:secondary*; D013736:Testicular Neoplasms / Q000188:drug therapy / Q000473:pathology*
D000970:Antineoplastic Agents