[Changes to calcium-phosphate metabolism associated with chronic nephropathies].
The paper discusses bone mineral and bone disorders associated with chronic nephropathies that are a logical consequence of reduced renal function. These are principally driven by changes in parathormone production and vitamin D synthesis. Bones are usually affected by renal osteopathy - osteodystrophy with abnormities of bone turnover, mineralization and volume, and with growth retardation in children. Extra-skeletal calcifications may occur, of which vascular wall localization is the most serious. A collection of pathologies develops, now termed chronic kidney disease - mineral and bone disorder (CKD-MBD).
Oddeleni Klinicke endokrinologie , Ustredni vojenske nemocnice, Praha.
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Blahoš
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Sotorník
D002118:Calcium / Q000378:metabolism*; D002908:Chronic Disease; D012080:Chronic Kidney Disease-Mineral and Bone Disorder / Q000378:metabolism*; D006801:Humans; D007674:Kidney Diseases / Q000150:complications / Q000378:metabolism*; D010710:Phosphates / Q000378:metabolism*; D011379:Prognosis; D061205:Vascular Calcification / Q000209:etiology / Q000628:therapy; D014807:Vitamin D / Q000378:metabolism / Q000502:physiology
D010710:Phosphates; D014807:Vitamin D; D002118:Calcium