Successful treatment by adding duloxetine to pregabalin for peripheral neuropathy induced by paclitaxel.
Although paclitaxel is a commonly used anticancer drug, peripheral neuropathy may develop as a side effect. Worsening of the symptoms with time may cause patients who receive paclitaxel to give up their chemotherapy. Duloxetine, a serotonin- and norepinephrine-reuptake inhibitor, has been used to treat peripheral neuropathic pain. We report the case of a 68-year-old man with gastric cancer, who underwent gastrectomy and then received 8 cycles of chemotherapy involving weekly administrations of paclitaxel. Under this paclitaxel treatment, he complained of severe peripheral neuropathy, leading to a diminished quality of life. Following treatment with a combination of duloxetine and pregabalin, a remission of his symptoms was achieved. Duloxetine plus pregabalin therapy may be useful for the peripheral neuropathy induced by paclitaxel.
1Department of Anesthesiology and Pain Medicine, Gifu University Graduate School of Medicine, Yanagido, Gifu City, Gifu, Japan.
Motoyasu
M
Takenaka
Hiroki
H
Iida
Shigemi
S
Matsumoto
Shinobu
S
Yamaguchi
Noritaka
N
Yoshimura
Maki
M
Miyamoto
D000068736:Duloxetine Hydrochloride; D006801:Humans; D017239:Paclitaxel; D010523:Peripheral Nervous System Diseases / Q000139:chemically induced; D000069583:Pregabalin; D011788:Quality of Life; D013876:Thiophenes
D013876:Thiophenes; D000069583:Pregabalin; D000068736:Duloxetine Hydrochloride; D017239:Paclitaxel