Association between metabolic syndrome and Helicobacter pylori infection diagnosed by histologic status and serological status.
OBJECTIVE
We aimed to simultaneously evaluate the association between metabolic syndrome and Helicobacter pylori (HP) infection diagnosed histologically and serologically in a large number of healthy Korean adults.


BACKGROUND
Serological positivity for HP does not necessarily indicate current infection. No study to date has compared the association between metabolic syndrome and HP infection diagnosed by histologic and serological status.


METHODS
HP status was ascertained histologically and serologically in healthy Korean adults who underwent comprehensive health screening in a private health screening center in Korea. Metabolic syndrome was defined according to the International Diabetes Federation definition. Multivariate logistic analyses were performed, after adjusting for potential confounders, including age, sex, smoking, alcohol consumption, and income level.


RESULTS
A total of 5889 subjects were included in the analysis. The metabolic syndrome was more strongly associated with histologic positivity for HP [adjusted odds ratio (aOR)=1.26; 95% confidence interval (CI), 1.08-1.48] than serologic positivity (aOR=1.12, 95% CI, 0.95-1.32), after adjusting for age, sex, smoking status, alcohol consumption, and economic status.


CONCLUSIONS
The stronger association between metabolic syndrome and histologic positivity than serological positivity suggests that the effects of HP infection on the pathogenesis of cardiometabolic outcomes may be reversible. Further prospective studies are needed.
Department of Family Medicine, Health Promotion Center, Seoul National University Hospital, Seoul, South Korea.
Dong Wook
DW
Shin
Hyuk Tae
HT
Kwon
Jung Min
JM
Kang
Jin Ho
JH
Park
Ho Chun
HC
Choi
Min Seon
MS
Park
Sang Min
SM
Park
Ki Young
KY
Son
BeLong
B
Cho
D000328:Adult; D000907:Antibodies, Bacterial / Q000097:blood*; D001786:Blood Glucose; D001794:Blood Pressure; D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D016001:Confidence Intervals; D005260:Female; D016481:Helicobacter Infections / Q000150:complications / Q000276:immunology* / Q000473:pathology*; D016480:Helicobacter pylori / Q000276:immunology*; D006801:Humans; D016015:Logistic Models; D008297:Male; D024821:Metabolic Syndrome / Q000097:blood / Q000150:complications*; D008875:Middle Aged; D015999:Multivariate Analysis; D056128:Obesity, Abdominal / Q000150:complications; D016017:Odds Ratio; D056910:Republic of Korea; D012189:Retrospective Studies; D014280:Triglycerides / Q000097:blood
D000907:Antibodies, Bacterial; D001786:Blood Glucose; D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D014280:Triglycerides