Molecular insights on context-specific role of profilin-1 in cell migration.
Profilin-1 (Pfn1) is a ubiquitously expressed actin-monomer binding protein that has been linked to many cellular activities ranging from control of actin polymerization to gene transcription. Traditionally, Pfn1 has been considered to be an essential control element for actin polymerization and cell migration. Seemingly contrasting this view, a few recent studies have shown evidence of an inhibitory action of Pfn1 on motility of certain types of carcinoma cells. In this review, we summarize biochemistry and functional aspects of Pfn1 in normal cells and bring in newly emerged action of Pfn1 in cancer cells that may explain its context-specific role in cell migration.
Department of Bioengineering, University of Pittsburgh, Pittsburgh, PA, USA.
Zhijie
Z
Ding
Yong Ho
YH
Bae
Partha
P
Roy
D000199:Actins / Q000737:chemistry; D000818:Animals; D002448:Cell Adhesion; D045744:Cell Line, Tumor; D002465:Cell Movement; D022081:Cell Surface Extensions / Q000378:metabolism; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D019269:Phosphatidylinositol 4,5-Diphosphate / Q000378:metabolism; D058105:Polymerization; D051304:Profilins / Q000235:genetics / Q000378:metabolism*; D011485:Protein Binding; D025941:Protein Interaction Mapping; D021381:Protein Transport
D000199:Actins; C495738:PFN1 protein, human; D019269:Phosphatidylinositol 4,5-Diphosphate; D051304:Profilins