Two new polyketides from a marine sediment-derived fungus Eutypella scoparia FS26.
Two new polyketides, 7,8-dihydroxy-3,5,7-trimethyl-8,8a-dihydro-1H-isochromen-6(7H)-one (1) and 6-(hydroxymethyl)-2,2-dimethyl-3,4-dihydro-2H-chromene-3,4-diol (2), together with a known nitrogen-containing polyketide (cytochalasin-type of metabolites), [12]-cytochalasin (3), have been isolated from the fermentation broth of a marine sediment-derived fungus Eutypella scoparia FS26 obtained from the South China Sea. Their structures were elucidated by spectroscopic methods, mainly 1D and 2D NMR spectroscopic techniques. The absolute configurations of compound 1 were determined by NOESY analysis and the literature data were compared with circular dichroism (CD) spectroscopy. The cytotoxic effects on MCF-7, NCI-H460 and SF-268 cell lines of all compounds were evaluated by the sulforhodamine B method.
Guangdong Provincial Key Laboratory of Microbial Culture Collection and Application, Guangdong Provincial Open Laboratory of Applied Microbiology, State Key Laboratory of Applied Microbiology (Ministry-Guangdong Province Jointly Breeding Base), Guangdong Institute of Microbiology, South China, Guangzhou 510070, P R China.
Li
L
Sun
Dongli
D
Li
Meihua
M
Tao
Yuchan
Y
Chen
Qingbo
Q
Zhang
Feijun
F
Dan
Weimin
W
Zhang
D001203:Ascomycota / Q000737:chemistry*; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D002681:China; D002942:Circular Dichroism; D045424:Complex Mixtures / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D005285:Fermentation; D019015:Geologic Sediments / Q000382:microbiology*; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D008958:Models, Molecular; D015394:Molecular Structure; D009792:Oceans and Seas; D061065:Polyketides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D012235:Rhodamines; D018675:Toxicity Tests
D045424:Complex Mixtures; D061065:Polyketides; D012235:Rhodamines; C022027:lissamine rhodamine B