Formulation and in vitro evaluation of prolonged release floating microspheres of atenolol using multicompartment dissolution apparatus.
The aim of the present work was to prepare floating microspheres of atenolol as prolonged release multiparticulate system and evaluate it using novel multi-compartment dissolution apparatus. Atenolol loaded floating microspheres were prepared by emulsion solvent evaporation method using 3² full factorial design. Formulations F1 to F9 were prepared using two independent variables (polymer ratio and % polyvinyl alcohol) and evaluated for dependent variables (particle size, percentage drug entrapment efficiency and percentage buoyancy). The formulation(F8) with particle size of 329 ± 2.69 µm, percentage entrapment efficiency of 61.33% and percentage buoyancy of 96.33% for 12 h was the of optimized formulation (F8). The results of factorial design revealed that the independent variables significantly affected the particle size, percentage drug entrapment efficiency and percentage buoyancy of the microspheres. In vitro drug release study revealed zero order release from F8 (98.33% in 12 h). SEM revealed the hollow cavity and smooth surface of the hollow microspheres.
Department of Pharmaceutics, Rajiv academy for Pharmacy , Mathura , India.
Priyanka
P
Bhadouriya
Manish
M
Kumar
Kamla
K
Pathak
D058671:Adrenergic beta-1 Receptor Antagonists / Q000737:chemistry*; D000959:Antihypertensive Agents / Q000737:chemistry*; D001262:Atenolol / Q000737:chemistry*; D002482:Cellulose / Q000031:analogs & derivatives / Q000737:chemistry; D055598:Chemical Phenomena; D003692:Delayed-Action Preparations / Q000737:chemistry; D004339:Drug Compounding; D004355:Drug Stability; D004356:Drug Storage; D004655:Emulsions; D005079:Excipients / Q000737:chemistry*; D005163:Factor Analysis, Statistical; D007700:Kinetics; D008855:Microscopy, Electron, Scanning; D008863:Microspheres; D010316:Particle Size; D011108:Polymers / Q000737:chemistry*; D011109:Polymethacrylic Acids / Q000737:chemistry; D012984:Software; D012995:Solubility; D013046:Specific Gravity; D013499:Surface Properties
D058671:Adrenergic beta-1 Receptor Antagonists; D000959:Antihypertensive Agents; D003692:Delayed-Action Preparations; D004655:Emulsions; D005079:Excipients; D011108:Polymers; D011109:Polymethacrylic Acids; C038300:methylmethacrylate-methacrylic acid copolymer; D001262:Atenolol; C013517:ethyl cellulose; D002482:Cellulose