Killer cell immunoglobulin like receptor gene association with tuberculosis.
NK cells are vital components of innate immune system and are the first cells which come into picture mediating resistance against intracellular pathogens. NK cell cytotoxicity is modulated by a wide variety of cell surface receptors that recognize and respond towards infected cells. Activation of NK cells are controlled by both inhibitory and activating receptors, encoded by KIR genes and bind to HLA ligands. Not much is known about KIR genes and their influence on the pathogenesis with M. tuberculosis infection. Our study aimed at detecting the presence of 14 KIR genes, their distribution and their association with tuberculosis. Total 77 different genotype combinations were observed which belonged to B-haplotype. Fifteen genotypes were similar to those reported in other world populations while remaining 62 were unique to this study group. Inhibitory genes KIR3DL1, KIR2DL3 and activating genes KIR2DS1, KIR2DS5 conferred susceptibility towards TB either individually or in haplotype combinations. The complimentary MHC ligands need to be tested for the functional relevance of the associated genes.
LEPRA-India, Blue Peter Public Health & Research Centre, Cherlapally, Hyderabad, AP, India. sudheerpydi@gmail.com
Satya Sudheer
SS
Pydi
Sharada Ramaseri
SR
Sunder
Sambasivan
S
Venkatasubramanian
Srinivas
S
Kovvali
Subbanna
S
Jonnalagada
Vijaya Lakshmi
VL
Valluri
D000328:Adult; D016022:Case-Control Studies; D005260:Female; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D060005:Genotyping Techniques; D006680:HLA Antigens / Q000235:genetics / Q000276:immunology; D006239:Haplotypes; D006801:Humans; D007113:Immunity, Innate; D007194:India; D007694:Killer Cells, Natural / Q000276:immunology / Q000382:microbiology*; D015810:Linkage Disequilibrium; D008297:Male; D008875:Middle Aged; D009169:Mycobacterium tuberculosis / Q000254:growth & development*; D011110:Polymorphism, Genetic; D054340:Receptors, KIR / Q000235:genetics* / Q000276:immunology; D054344:Receptors, KIR2DL3 / Q000235:genetics* / Q000276:immunology; D054341:Receptors, KIR3DL1 / Q000235:genetics* / Q000276:immunology; D014397:Tuberculosis, Pulmonary / Q000175:diagnosis / Q000453:epidemiology / Q000235:genetics* / Q000382:microbiology
D006680:HLA Antigens; C515078:KIR2DL3 protein, human; C496212:KIR2DS1 protein, human; C531595:KIR2DS5 protein, human; C515083:KIR3DL1 protein, human; D054340:Receptors, KIR; D054344:Receptors, KIR2DL3; D054341:Receptors, KIR3DL1