Synthesis and reduction kinetics of sterically shielded pyrrolidine nitroxides.
A series of sterically shielded pyrrolidine nitroxides were synthesized, and their reduction by ascorbate (vitamin C) indicate that nitroxide 3, a tetraethyl derivative of 3-carboxy-PROXYL, is reduced at the slowest rate among known nitroxides, i.e., at a 60-fold slower rate than that for 3-carboxy-PROXYL.
Department of Chemistry, University of Nebraska, Lincoln, Nebraska 68588-0304, USA.
Joseph T
JT
Paletta
Maren
M
Pink
Bridget
B
Foley
Suchada
S
Rajca
Andrzej
A
Rajca
D001205:Ascorbic Acid / Q000737:chemistry; D007700:Kinetics; D008958:Models, Molecular; D015394:Molecular Structure; D009589:Nitrogen Oxides / Q000138:chemical synthesis*; D010084:Oxidation-Reduction; D011759:Pyrrolidines / Q000138:chemical synthesis*
D009589:Nitrogen Oxides; D011759:Pyrrolidines; C039900:nitroxyl; C032519:pyrrolidine; D001205:Ascorbic Acid