Axial distribution of nitric oxide airway production in asthma patients.
In healthy subjects, axial distribution of nitric oxide (NO) airway production is likely heterogeneous: notably a distal peak of production in terminal bronchioles and a quasi-nil NO production in the most of the conducting airways. In asthma, few information exists about the contributions of the proximal and distal airways to NO overproduction. In 18 asthma patients, sites of constriction after methacholine and adenosine 5'-monophosphate (AMP) challenges were assessed by ventilation distribution tests with He and SF(6). The resulting decreases in fractional exhaled NO (FENO) were measured. Changes in He and SF(6) slopes indicated a pre-acinar bronchoconstriction due to AMP and a more proximal action for methacholine. FENO decreased by 38.7% and 20.2% (p<0.001) after AMP and methacholine challenges, respectively. Significant FENO decreases after AMP and methacholine implies substantial pre-acinar but also, contrary to healthy subjects, more proximal airway production. In conclusion, nitric oxide overproduction in asthma patients appears to involve the most part of the conducting airways.
Chest Department, Erasme University Hospital, Université Libre de Bruxelles, Brussels, Belgium. avmuylem@ulb.ac.be
Alain
A
Van Muylem
Yannick
Y
Kerckx
Alain
A
Michils
D000249:Adenosine Monophosphate; D000305:Adrenal Cortex Hormones / Q000378:metabolism; D000328:Adult; D001249:Asthma / Q000378:metabolism* / Q000473:pathology* / Q000503:physiopathology; D001944:Breath Tests; D001980:Bronchi / Q000187:drug effects / Q000378:metabolism*; D016084:Bronchoconstriction / Q000187:drug effects; D018592:Cross-Over Studies; D005260:Female; D005541:Forced Expiratory Volume; D006801:Humans; D008297:Male; D016210:Methacholine Chloride; D008875:Middle Aged; D018721:Muscarinic Agonists; D009569:Nitric Oxide / Q000378:metabolism*; D012123:Pulmonary Ventilation / Q000187:drug effects / Q000502:physiology*; D016037:Single-Blind Method; D014797:Vital Capacity / Q000187:drug effects
D000305:Adrenal Cortex Hormones; D018721:Muscarinic Agonists; D016210:Methacholine Chloride; D009569:Nitric Oxide; D000249:Adenosine Monophosphate