[Association of the mutations in the human mitochondrial genome with chronic non-inflammatory diseases: type 2 diabetes, hypertension and different types of cardiomyopathy].
Genetic predisposition is of great importance among other risk factors of certain socially significant chronic non-inflammatory diseases. Changes in both nuclear and mitochondrial human genome may play a role in the development of these diseases. Recent studies have shown that mutations in the mitochondrial genome are associated with some diseases, such as type 2 diabetes, hypertension, and various types of cardiomyopathy. Maternal inheritance in some cases suggests that their cause may be precisely the defects of mitochondrial DNA.
A V
AV
Zhelankin
M A
MA
Sazonova
D009202:Cardiomyopathies / Q000235:genetics*; D002908:Chronic Disease; D004272:DNA, Mitochondrial / Q000235:genetics; D003924:Diabetes Mellitus, Type 2 / Q000235:genetics*; D054629:Genome, Mitochondrial / Q000235:genetics*; D006801:Humans; D006973:Hypertension / Q000235:genetics*; D009154:Mutation
D004272:DNA, Mitochondrial