Vitamin B-6 vitamer levels in plasma and related symptoms in hemodialysis subjects taking low- and high-dose renal multivitamin supplements.
BACKGROUND
The purpose of this study was to evaluate the B-6 vitamers in plasma and related symptoms in hemodialysis subjects taking high- or low-dose vitamins.


METHODS
A total of 24 hemodialysis (HD) subjects were divided into two groups. Twelve subjects received a high-dose vitamin supplement [50 mg pyridoxine hydrochloride (PN-HCl) /tablet] and 12 received a low-dose vitamin supplements containing (10 mg PN-HCl/tablet) for 6+ months. Plasma B-6 vitamers were analyzed using HPLC. Other data were obtained from subjects' medical records. Subjects were assessed for vitamin B-6 related symptoms. Cluster analysis was used to form symptom groups. Student t-tests and analysis of variance were used to determine differences (p < 0.05) in group means.


RESULTS
The mean ± SD plasma B-6 vitamer and 4-pyridoxic acid concentrations (nmol/L) were as follows in the 10-mg and 50-mg PN-HCl groups, respectively: pyridoxal- 5'-phosphate (PLP) 10 ± 3 and 16 ± 8 (p = 0.04); pyridoxal (PL) 50 ± 96 and 68 ± 06; pyridoxine (PN) 26 ± 50 and 191 ± 107; and 4-pyridoxic acid (4-PA) 43 ± 64 and 99 ± 361. The cluster group with a significantly higher (p = 0.04) plasma 4-PA concentration of 167 ± 697 nmol/L reported more tingling hands, tachycardia, and diarrhea.


CONCLUSIONS
Plasma PLP levels and symptoms related to B-6 in HD subjects are impacted by dose of PN-HCl.
South Plains Kidney Disease Center, Lubbock, TX, USA.
Louise
L
Clement
Mallory
M
Boylan
Virginia
V
Miller
Judy
J
Driskell
David
D
Giraud
Hadil
H
Subih
D019587:Dietary Supplements; D004305:Dose-Response Relationship, Drug; D006801:Humans; D010523:Peripheral Nervous System Diseases / Q000139:chemically induced*; D011730:Pyridoxal / Q000097:blood; D011732:Pyridoxal Phosphate / Q000097:blood; D011735:Pyridoxic Acid / Q000097:blood; D011736:Pyridoxine / Q000008:administration & dosage* / Q000097:blood; D006435:Renal Dialysis; D025101:Vitamin B 6 / Q000009:adverse effects* / Q000097:blood*; D014815:Vitamins / Q000008:administration & dosage*
D014815:Vitamins; D011730:Pyridoxal; D011735:Pyridoxic Acid; D011732:Pyridoxal Phosphate; D025101:Vitamin B 6; D011736:Pyridoxine