Power shifts track serial position and modulate encoding in human episodic memory.
The first events in a series exert a powerful influence on cognition and behavior in both humans and animals. This is known as the law of primacy. Here, we analyze the neural correlates of primacy in humans by analyzing electrocorticographic recordings in 84 neurosurgical patients as they studied and subsequently recalled lists of common words. We found that spectral power in the gamma frequency band (28-100 Hz) was elevated at the start of the list and gradually subsided, whereas lower frequency (2-8 Hz) delta and theta band power exhibited the opposite trend. This gradual shift in the power spectrum was found across a widespread network of brain regions. The degree to which the subsequent memory effect was modulated by list (serial) position was most pronounced in medial temporal lobe structures. These results suggest that globally increased gamma and decreased delta-theta spectral powers reflect a brain state that predisposes medial temporal lobe structures to enhance the encoding and maintenance of early list items.
Department of Neurology, Thomas Jefferson University, Philadelphia, PA 19107, USA.
Mijail D
MD
Serruya
Per B
PB
Sederberg
Michael J
MJ
Kahana
D000293:Adolescent; D000328:Adult; D001921:Brain / Q000502:physiology* / Q000601:surgery; D001931:Brain Mapping; D002648:Child; D003700:Delta Rhythm; D004567:Electrodes, Implanted; D004569:Electroencephalography; D005260:Female; D006801:Humans; D008297:Male; D061212:Memory, Episodic; D008875:Middle Aged; D009483:Neuropsychological Tests; D017397:Prefrontal Cortex / Q000502:physiology; D013702:Temporal Lobe / Q000502:physiology; D013826:Theta Rhythm; D014825:Vocabulary; D055815:Young Adult