An implantable optical blood pressure sensor based on pulse transit time.
An implantable sensor system for long-term monitoring of blood pressure is realized by taking advantage of the correlation between pulse transit time and blood pressure. The highly integrated implantable sensor module, fabricated using MEMS technologies, uses 8 light emitting diodes (LEDs) and a photodetector on chip level. The sensor is applied to large blood vessels, such as the carotid or femoral arteries, and allows extravascular measurement of highly-resolved photoplethysmograms. In addition, spectrophotometric approaches allow measurement of hemoglobin derivatives. For the calibration of blood pressure measurements, the sensor system has been successfully implemented in animal models.
Department of Microsystems Engineering (IMTEK), Laboratory for Micro-Optics, University of Freiburg, Georges-Koehler-Allee 102, Freiburg, 79110, Germany. jens.fiala@imtek.uni-freiburg.de
Jens
J
Fiala
Philipp
P
Bingger
Dominic
D
Ruh
Katharina
K
Foerster
Claudia
C
Heilmann
Friedhelm
F
Beyersdorf
Hans
H
Zappe
Andreas
A
Seifert
D000818:Animals; D001795:Blood Pressure Determination / Q000295:instrumentation*; D002138:Calibration; D002339:Carotid Arteries / Q000502:physiology; D005260:Female; D055096:Optical Devices; D019736:Prostheses and Implants; D063177:Pulse Wave Analysis / Q000295:instrumentation*; D015203:Reproducibility of Results; D013552:Swine