Tolerability, safety, and efficacy of PEG 3350 as a 1-day bowel preparation in children.
OBJECTIVE
The aim of the study was to evaluate the tolerability, safety, and efficacy of polyethylene glycol (PEG) 3350 without electrolytes as a 1-day bowel preparation for colonoscopy in children.


METHODS
A prospective study of 45 children undergoing colonoscopy prescribed PEG 3350 without electrolytes mixed with a commercial electrolyte beverage was performed. Patients <45 kg received 136 g of PEG 3350 without electrolytes mixed in 32 ounces of Gatorade. Patients ≥ 45 kg were given 255 g of PEG 3350 without electrolytes in 64 ounces of Gatorade A basic metabolic panel was performed at the time of the clinic visit and just before colonoscopy. Patients completed a survey related to bowel preparation. Endoscopists graded bowel preparation and noted the proximal extent of the examination.


RESULTS
A total of 44 patients (14 ± 3 years) completed the study. One patient was excluded due to protocol breach. All subjects reported the preparation was easy (61%) or tolerable (39%). Adverse events included nausea (34%), abdominal pain (23%), vomiting (16%), abdominal distension (20%), bloating (23%), and dizziness (7%). Although significant changes in serum glucose and CO2 were noted, no therapeutic interventions were indicated. Significant changes in sodium, potassium chloride, blood urea nitrogen, or creatinine did not occur. Colonic preparation was rated as excellent in 23%, good in 52%, fair in 23%, and poor in 2% of patients. Intubation of the ileum was successful in 100%.


CONCLUSIONS
One-day bowel preparation with high dose PEG 3350 mixed with commercial electrolyte solution is tolerable, safe, and effective in children before colonoscopy.
Department of Pediatric Gastroenterology and Nutrition, Cleveland Clinic Children's Hospital, Cleveland, OH 44195 , USA. ritubatra2000@hotmail.com
Ritu
R
Walia
Rita
R
Steffen
Lisa
L
Feinberg
Sarah
S
Worley
Lori
L
Mahajan
D015746:Abdominal Pain; D000293:Adolescent; D001786:Blood Glucose / Q000378:metabolism; D002245:Carbon Dioxide / Q000097:blood; D002400:Cathartics; D002648:Child; D003106:Colon / Q000601:surgery; D003113:Colonoscopy / Q000379:methods*; D004244:Dizziness; D005260:Female; D006801:Humans; D008297:Male; D009325:Nausea; D017060:Patient Satisfaction; D011092:Polyethylene Glycols; D014839:Vomiting
D001786:Blood Glucose; D002400:Cathartics; D002245:Carbon Dioxide; D011092:Polyethylene Glycols