Transition metal-free direct C-H bond thiolation of 1,3,4-oxadiazoles and related heteroarenes.
A convenient transition metal-free procedure for the direct thiolation of 1,3,4-oxadiazole C-H bonds using diaryl disulfides has been developed. Other substrates including indole, benzothiazole, N-phenylbenzimidazole, and caffeine were also thiolated in this manner, providing the corresponding products in good to excellent yields.
Institute of Organic Chemistry, RWTH Aachen University, Landoltweg 1, 52074 Aachen, Germany.
Liang-Hua
LH
Zou
Jens
J
Reball
Jakob
J
Mottweiler
Carsten
C
Bolm
D052160:Benzothiazoles / Q000737:chemistry; D002110:Caffeine / Q000737:chemistry; D002244:Carbon / Q000737:chemistry; D006859:Hydrogen / Q000737:chemistry; D007211:Indoles / Q000737:chemistry; D010069:Oxadiazoles / Q000737:chemistry*; D013438:Sulfhydryl Compounds / Q000737:chemistry; D028561:Transition Elements / Q000737:chemistry*
D052160:Benzothiazoles; D007211:Indoles; D010069:Oxadiazoles; D013438:Sulfhydryl Compounds; D028561:Transition Elements; D002110:Caffeine; D002244:Carbon; D006859:Hydrogen; C030374:indole; C005465:benzothiazole