The not-so-skinny on muscle cancer.
The childhood cancer embryonal rhabdomyosarcoma can arise in tissue without skeletal muscle elements. In this issue of Cancer Cell, Hatley and colleagues report that non-skeletal muscle progenitors can be a cell of origin for Sonic Hedgehog-driven embryonal rhabdomyosarcoma in an adipocyte-restricted conditional mouse model.
Pediatric Cancer Biology Program, Papé Family Pediatric Research Institute, Department of Pediatrics, Oregon Health & Science University, Portland, OR 97239, USA.
Ken
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Kikuchi
Charles
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Keller