The extended functional neuroanatomy of emotional processing biases for masked faces in major depressive disorder.
BACKGROUND
Major depressive disorder (MDD) is associated with a mood-congruent processing bias in the amygdala toward face stimuli portraying sad expressions that is evident even when such stimuli are presented below the level of conscious awareness. The extended functional anatomical network that maintains this response bias has not been established, however.


OBJECTIVE
To identify neural network differences in the hemodynamic response to implicitly presented facial expressions between depressed and healthy control participants.


METHODS
Unmedicated-depressed participants with MDD (n=22) and healthy controls (HC; n=25) underwent functional MRI as they viewed face stimuli showing sad, happy or neutral face expressions, presented using a backward masking design. The blood-oxygen-level dependent (BOLD) signal was measured to identify regions where the hemodynamic response to the emotionally valenced stimuli differed between groups.


RESULTS
The MDD subjects showed greater BOLD responses than the controls to masked-sad versus masked-happy faces in the hippocampus, amygdala and anterior inferotemporal cortex. While viewing both masked-sad and masked-happy faces relative to masked-neutral faces, the depressed subjects showed greater hemodynamic responses than the controls in a network that included the medial and orbital prefrontal cortices and anterior temporal cortex.


CONCLUSIONS
Depressed and healthy participants showed distinct hemodynamic responses to masked-sad and masked-happy faces in neural circuits known to support the processing of emotionally valenced stimuli and to integrate the sensory and visceromotor aspects of emotional behavior. Altered function within these networks in MDD may establish and maintain illness-associated differences in the salience of sensory/social stimuli, such that attention is biased toward negative and away from positive stimuli.
National Institutes of Health, National Institute of Mental Health, Bethesda, Maryland, USA. tvictor@laureateinstitute.org
Teresa A
TA
Victor
Maura L
ML
Furey
Stephen J
SJ
Fromm
Patrick S F
PS
Bellgowan
Arne
A
Öhman
Wayne C
WC
Drevets
D001921:Brain / Q000503:physiopathology; D016022:Case-Control Studies; D003865:Major Depressive Disorder / Q000503:physiopathology*; D004644:Emotions; D005149:Facial Expression; D006801:Humans; D008279:Magnetic Resonance Imaging