[Influence of interleukin-13 on bioelectrical activity of rat atrial cardiomyocytes in normal and stretch conditions].
We studied the effect of anti-inflammatory ininterleukin-13 (IL-13; 50 ng/ml) on bioelectrical activity of rat atrial cardiomyocytes under control conditions and on the background of stretch by means of microelectrode technique. IL-13 did not lead to alterations of the resting membrane potential and action potential amplitude during 35 minutes. However APD25, APD50, APD90 in 50% of cases significantly decreased, while in other 50% of cases it increased. In case when IL-13 decreased APD cellular stretch by 1.7 mN caused an increase in APD frequency by 120% and caused decrease in APD25, APD50, APD90, which happened on the background of modest cellular depolarization in the range of 5 mV. When IL-13 increased APD, tissue stretching just by 0.8 mN caused depression of the frequency by 10% and increase in APD25, APD50, APD90. This happened on the background of small cellular depolarization.
V M
VM
Mitrokhin
E Iu
EIu
Makarenko
D V
DV
Abramochkin
A G
AG
Kamkin
D000200:Action Potentials / Q000187:drug effects*; D000818:Animals; D006325:Heart Atria / Q000187:drug effects; D018793:Interleukin-13 / Q000008:administration & dosage*; D008564:Membrane Potentials / Q000187:drug effects*; D008839:Microelectrodes; D032383:Myocytes, Cardiac / Q000187:drug effects / Q000502:physiology; D051381:Rats; D017208:Rats, Wistar
D018793:Interleukin-13