New components of the necroptotic pathway.
Programmed necrosis, also known as necroptosis, has recently drawn great attention. As an important cellular regulation mechanism, knowledge of its signaling components is expanding. Necroptosisis demonstrated to be regulated by the RIP1 and RIP3 kinases, and its pathophysiological importance has been confirmed in a number of disease models. Here we review the new members of this necroptosis pathway, MLKL, PGAM5, Drp1 and DAI, and discuss some of their possible applications according to recent findings.
State Key Laboratory of Cellular Stress Biology and School of Life Sciences, Xiamen University, Xiamen, China.
Zhenru
Z
Zhou
Victor
V
Han
Jiahuai
J
Han
D000818:Animals; D002352:Carrier Proteins / Q000378:metabolism; D004268:DNA-Binding Proteins / Q000378:metabolism; D034281:Dynamins; D020558:GTP Phosphohydrolases / Q000378:metabolism; D006801:Humans; D008869:Microtubule-Associated Proteins / Q000378:metabolism; D024101:Mitochondrial Proteins / Q000378:metabolism; D009336:Necrosis; D010749:Phosphoprotein Phosphatases; D011494:Protein Kinases / Q000737:chemistry / Q000378:metabolism; D016601:RNA-Binding Proteins; D053422:Receptor-Interacting Protein Serine-Threonine Kinases / Q000378:metabolism; D015398:Signal Transduction; D048069:Tumor Necrosis Factors / Q000378:metabolism
D002352:Carrier Proteins; D004268:DNA-Binding Proteins; D008869:Microtubule-Associated Proteins; D024101:Mitochondrial Proteins; D016601:RNA-Binding Proteins; D048069:Tumor Necrosis Factors; C485731:ZBP1 protein, human; C570693:MLKL protein, human; D011494:Protein Kinases; C506249:RIPK1 protein, human; C119705:RIPK3 protein, human; D053422:Receptor-Interacting Protein Serine-Threonine Kinases; C529563:PGAM5 protein, human; D010749:Phosphoprotein Phosphatases; D020558:GTP Phosphohydrolases; C110768:DNM1L protein, human; D034281:Dynamins