Dosimetry in pleural photodynamic therapy.
Photodynamic therapy (PDT) centers on the photochemical interaction of 3 principal components: light, photosensitizer, and oxygen. Over the past 25 years, much has been learned about the basic biophysical mechanisms of PDT, and in the future, a clearer understanding of the physics of PDT will make it possible to translate this science into improved clinical treatments. This article explores the role of explicit dosimetry in PDT and the need for individualized determination of dosimetric parameters based on the heterogeneity of optical properties and photosensitizer drug concentration. In addition, the use of a navigation system to help deliver uniform light for pleural PDT is briefly discussed.
Division of Medical Physics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA. tzhu@mail.med
Timothy C
TC
Zhu
D006801:Humans; D008027:Light; D008175:Lung Neoplasms / Q000188:drug therapy* / Q000473:pathology; D010778:Photochemotherapy; D017319:Photosensitizing Agents / Q000627:therapeutic use; D010997:Pleural Neoplasms / Q000188:drug therapy* / Q000473:pathology; D011829:Radiation Dosage; D026082:Singlet Oxygen
D017319:Photosensitizing Agents; D026082:Singlet Oxygen