Vascularized fibular grafts in patients with avascular necrosis of femoral head: a systematic review and meta-analysis.
BACKGROUND
Vascularized fibular grafting (VFG) has been initiated to treat avascular necrosis of the femoral head (ANFH) since the late 1970s. There are a number of review articles updating the use of VFG to treat the ANFH. None of them applied statistical analysis for combining results from different studies to obtain a quantitative estimate of the overall effect and potential harm of VFG in comparison to other treatment.


METHODS
Several electronic databases were searched to find studies using VFG to treat ANFH. The outcomes sought included Harris Score, failure rate (conversion to total hip arthroplasty (THA) and/or femoral head collapse), and complications rate. Included studies were assessed for methodological bias and estimates of effect were calculated. Potential reasons for heterogeneity were explored.


RESULTS
The clinical results of 69.0 % of VFG-treated patients and 25.0 % of non-VFG-treated patients were good to excellent (OR 0.13; p < 0.01). The conversion rate to THA of VFG-treated and that of other methods treated hips was 16.5 % and 42.6 % (OR 0.19; p < 0.001). Collapse rate of VFG-treated and that of non-VFG-treated hips was 16.7 % and 63.6 % (OR 0.09; p < 0.05). The complication rate of VFG-treated and that of other methods treated patients was 23.8 % and 8.9 % (OR 3.44; p = 0.09). For Steinberg stage I, II ANFH, failure rate of VFG-treated and that of non-VFG-treated hips was 9.8 % and 40.2 % (OR 0.17; p < 0.001). For Steinberg stage II, III ANFH, failure rate of VFG-treated and that of non-VFG-treated hips was 16.5 % and 42.8 %, respectively (OR 0.17; p < 0.001).


CONCLUSIONS
VFG is a justified method that can prevent the ANFH from progressing to collapse, and that can retard or avoid hip replacement, especially in the hips of Steinberg stage I, II, and III.
Department of Orthopedic Surgery, Zhongshan Hospital, Fudan University, 200032 Shanghai, China. tfang@umc.edu
Taolin
T
Fang
Elizabeth W
EW
Zhang
Frederick C
FC
Sailes
Robert A
RA
McGuire
William C
WC
Lineaweaver
Feng
F
Zhang
D016025:Bone Transplantation / Q000379:methods; D005271:Femur Head Necrosis / Q000601:surgery*; D005360:Fibula / Q000098:blood supply* / Q000637:transplantation*; D006801:Humans; D016896:Treatment Outcome