Hyperglycemia within day 14 of aneurysmal subarachnoid hemorrhage predicts 1-year mortality.
OBJECTIVE
To assess whether the fasting glucose level on admission, day 14 or their variation in patients with aSAH was associated with 1-year mortality.


METHODS
A prospective study was undertaken to analyze the effects of fasting glucose on admission, day 14 and their variation on the 1-year mortality rate after aSAH. Patients with aSAH were enrolled to assess the mortality rate relationship with fasting glucose, medical history, clinical and radiological grades. Multivariate Cox regression analysis was performed to assess risk factors for 1-year mortality.


RESULTS
A total of 239 aSAH patients without history of diabetes were followed up, with the 1-year mortality being 11.7%. Admission glucose levels were found to be associated with 1-year mortality after being adjusted for other confounding factors in Cox regression (HR: 1.524 per mmol/L; 95%CI, 1.250-1.859). Within 14 days, fasting glucose levels of 85 patients had increased. Patients who died also exhibited higher levels of glucose (dead vs. survival: 61.54% vs. 33.66%, p<0.01). In addition, higher blood glucose levels were associated with an elevated 1-year mortality (HR: 1.350 per mmol/L; 95%CI, 1.153-1.580).


CONCLUSIONS
Glucose levels at admission as well as their variation after aSAH are predictive of an elevated 1-year mortality rate.
Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
Liheng
L
Bian
Liping
L
Liu
Chunxue
C
Wang
Mohammed
M
Hussain
Yu
Y
Yuan
Gaifen
G
Liu
Wenjuan
W
Wang
Xingquan
X
Zhao
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001786:Blood Glucose / Q000378:metabolism; D015992:Body Mass Index; D003627:Data Interpretation, Statistical; D005260:Female; D005500:Follow-Up Studies; D015600:Glasgow Coma Scale; D006801:Humans; D006943:Hyperglycemia / Q000209:etiology* / Q000401:mortality*; D008055:Lipids / Q000097:blood; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D011446:Prospective Studies; D013345:Subarachnoid Hemorrhage / Q000150:complications* / Q000401:mortality*; D016019:Survival Analysis; D055815:Young Adult
D001786:Blood Glucose; D008055:Lipids