Pulpal and periodontal diseases increase triglyceride levels in diabetic rats.
OBJECTIVE
The aim of this study was to evaluate triglyceride and cholesterol levels in diabetic rats and their relationship with pulpal and periodontal diseases.


METHODS
Eighty male rats (Rattus norvegicus albinus, Wistar) were divided into the following eight groups comprising ten animals each: normal rats (G1), rats with pulpal diseases (G2), rats with periodontal diseases (G3), rats with both pulpal and periodontal diseases (G4), diabetic rats (G5), diabetic rats with pulpal diseases (G6), diabetic rats with periodontal diseases (G7), and diabetic rats with both periodontal and pulpal diseases (G8). Diabetes was induced by injecting streptozotocin, periapical lesions were induced by exposing pulpal tissue to the oral environment, and periodontal diseases were induced by periodontal ligature. The animals were killed after 30 days, and lipid profile was enzymatically measured using Trinder's method. The total assessed values were statistically analyzed by analysis of variance and Tukey test (p < 0.05).


RESULTS
The triglyceride levels of diabetic rats with periodontal disease and of diabetic rats with both periodontal and pulpal diseases were significantly higher than those of normal rats and nondiabetic group rats, respectively. The differences in the cholesterol levels among the groups were not significant.


CONCLUSIONS
We found that the association of pulpal and periodontal diseases with diabetes increased triglyceride levels in rats.


CONCLUSIONS
Changes in lipid profile may be related to the presence of oral infections and diabetes.
Endodontics, Araçatuba Dental School, UNESP-Univ Estadual Paulista, R. José Bonifácio, Araçatuba, 1193, São Paulo, Brazil. lucianocintra@foa.unesp.br
Luciano Tavares Angelo
LT
Cintra
Aguinaldo Cândido
AC
da Silva Facundo
Mariane Maffei
MM
Azuma
Dóris Hissako
DH
Sumida
Rafael Dias
RD
Astolphi
Suely Regina Mogami
SR
Bomfim
Luís Gustavo
LG
Narciso
João Eduardo
JE
Gomes-Filho
D000818:Animals; D001786:Blood Glucose / Q000032:analysis; D002784:Cholesterol / Q000097:blood; D003788:Dental Pulp Diseases / Q000097:blood*; D003789:Dental Pulp Exposure / Q000097:blood; D003921:Diabetes Mellitus, Experimental / Q000097:blood*; D006943:Hyperglycemia / Q000097:blood; D008297:Male; D010483:Periapical Diseases / Q000097:blood; D010510:Periodontal Diseases / Q000097:blood*; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar; D013311:Streptozocin; D014280:Triglycerides / Q000097:blood*
D001786:Blood Glucose; D014280:Triglycerides; D013311:Streptozocin; D002784:Cholesterol