Pathologic evaluation of appendectomy specimens in children: is routine histopatholgic examination indicated?
OBJECTIVE
Acute appendicitis is the most common cause of abdominal surgery in children. Similarity between signs and symptoms of appendicitis and other common pediatric illnesses, atypical manifestations of appendicitis in young children, and children's inability to give precise explanation for their symptoms contribute to considerable delay in proper diagnosis and increased rate of perforation. Current study reports the surgical and pathological findings of appendectomies in the largest Children's Hospital in Iran. It also evaluates whether common protocol for pathologic evaluation following appendectomy is beneficial.


METHODS
Pathologic reports of 947 appendectomies, performed with the presumptive diagnosis of acute appendicitis, were gathered. Correlation between surgical and pathologic findings was assessed. Demographic characteristics of patients between surgical and pathological subgroups were also compared.


RESULTS
The mean age of participants was 6.9±3.5 years. Eighty seven (25.5%) children had abnormal pathological findings and normal surgical report. None of miscellaneous findings including appendicular carcinoid tumor 3 (0.3%), oxyuriasis 2 (0.2%), and mycobacterial infection 4 (0.5%) were recognizable during the surgery. Of all pathologically confirmed cases with perforated appendicitis, 9.7% were not detected during the surgery.


CONCLUSIONS
In current study, acute appendicitis was the most common pathological diagnosis, however, high normal appendectomy rate along with noticeable proportion of surgically missed perforated appendicitis and unusual histopathologies strongly supported routine histological examination.
Department of Pathology, Tehran University of Medical Sciences, Tehran, Iran ; Children's Medical Center, Pediatric Center of Excellence, Tehran, Iran.
Maryam
M
Monajemzadeh
Mohammad-Taghi
MT
Hagghi-Ashtiani
Laleh
L
Montaser-Kouhsari
Hamed
H
Ahmadi
Heidar
H
Zargoosh
Mehdi
M
Kalantari