Association of CD14 G(-1145)A and C(-159)T polymorphisms with reduced risk for tuberculosis in a Chinese Han population.
Although the role of CD14 in mediating signals from  Toll-like receptors to recognize Mycobacterium tuberculosis is known,  how polymorphisms in this gene affect the susceptibility to develop  tuberculosis are still not clear. We examined whether single nucleotide  polymorphisms at positions -1145 and -159 in the promoter region of the CD14  gene are associated with tuberculosis in a Chinese Han population in a  case-control study of 432 Chinese patients with tuberculosis and 404 ethnically  matched healthy controls. Genotyping was performed to identify polymorphisms of  the CD14 gene by PCR-DNA sequencing. Both the frequency of allele T in the  C(-159)T polymorphism (odds ratio (OR) = 1.4; 95% confidence interval (95%CI) =  1.148-1.708) and allele G in the G(-1145)A polymorphism (OR = 1.512; 95%CI =  1.236- 1.849) were significantly more frequent in cases than in controls. The frequencies  of genotypes CC and CT in the C(-159)T polymorphism, as well as the frequencies  of genotypes AA and AG, were lower in cases than in controls. Based on our  results, we conclude that G(-1145)A and C(-159)T polymorphisms of CD14 are  associated with decreased risk for the development of tuberculosis in the  Chinese Han population.
Institute of Cell Biology, Zhejiang University, Hangzhou, China.
M Y
MY
Zhao
Y
Y
Xue
Z Q
ZQ
Zhao
F J
FJ
Li
D P
DP
Fan
L L
LL
Wei
X J
XJ
Sun
X
X
Zhang
X C
XC
Wang
Y X
YX
Zhang
J C
JC
Li
D000293:Adolescent; D000328:Adult; D000368:Aged; D019943:Amino Acid Substitution / Q000235:genetics*; D044466:Asian People / Q000235:genetics*; D001483:Base Sequence; D016022:Case-Control Studies; D002681:China; D004587:Electrophoresis, Agar Gel; D005006:Ethnicity / Q000235:genetics*; D005260:Female; D005787:Gene Frequency / Q000235:genetics; D020022:Genetic Predisposition to Disease; D006801:Humans; D018950:Lipopolysaccharide Receptors / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D008969:Molecular Sequence Data; D016133:Polymerase Chain Reaction; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D011401:Promoter Regions, Genetic / Q000235:genetics; D012307:Risk Factors; D014376:Tuberculosis / Q000235:genetics*; D055815:Young Adult
D018950:Lipopolysaccharide Receptors