Preorbital carcinoma in two Kirk's dik-diks (Madoqua kirkii).
Two Kirk's dik-diks suffered from chronic, unilateral, therapy-resistant enlargement of the preorbital gland. Computed tomographic imaging revealed a homogenous preorbital mass destroying the adjacent maxillary bone in one animal. Squamous cell carcinoma was diagnosed microscopically in both cases. Immunohistochemically, the neoplastic cells uniformly expressed cytokeratin (CK) 5/6 and CK14. Additionally, tumour cells were strongly labelled for p53 suggesting a possible role of this tumour suppressor gene in tumorigenesis. Chronic obstruction of the preorbital gland due to excessive accumulation of secretory products is considered as a likely cause of glandular and periglandular inflammation with subsequent malignant transformation.
Department of Pathology, University of Veterinary Medicine Hannover, Bünteweg 17, D-30559 Hannover, Germany.
J
J
Junginger
M
M
Kummerfeld
M
M
Kummrow
K
K
Grützmacher
P
P
Dziallas
P
P
Wohlsein
D000818:Animals; D000866:Antelopes; D002294:Carcinoma, Squamous Cell / Q000235:genetics / Q000473:pathology / Q000662:veterinary*; D002471:Cell Transformation, Neoplastic / Q000235:genetics; D005088:Exocrine Glands / Q000473:pathology*; D012983:Soft Tissue Neoplasms / Q000235:genetics / Q000473:pathology / Q000662:veterinary*