Medication detection by a combinatorial fluorescent molecular sensor.
Working together to uncover the truth: A molecule-sized diagnostic system combining several recognition elements and four fluorescence-emission channels enabled the identification of a wide range of pharmaceuticals on the basis of distinct photophysical processes. The molecular sensor (see simplified representation; ID = identification) was also used to analyze drug concentrations and combinations in urine samples in a high-throughput manner.
Department of Organic Chemistry, Weizmann Institute of Science, 76100, Rehovot, Israel.
Bhimsen
B
Rout
Linor
L
Unger
Gad
G
Armony
Mark A
MA
Iron
David
D
Margulies
D000900:Anti-Bacterial Agents / Q000032:analysis / Q000652:urine; D004579:Electron Transport; D031541:Fluorescence Resonance Energy Transfer; D005456:Fluorescent Dyes / Q000737:chemistry; D006801:Humans; D008968:Molecular Conformation; D004364:Pharmaceutical Preparations / Q000032:analysis* / Q000652:urine; D019095:Point-of-Care Systems; D025341:Principal Component Analysis
D000900:Anti-Bacterial Agents; D005456:Fluorescent Dyes; D004364:Pharmaceutical Preparations