Synthesis of 4,6-disubstituted 2-(4-morpholinyl)pyrimidines by cross-coupling reactions using triorganoindium compounds.
4,6-Disubstituted-2-(4-morpholinyl)pyrimidines, an important class of bioactive compounds, have been synthesized from 4,6-dichloro-2-(4-morpholinyl)pyrimidine by selective and sequential palladium-catalyzed cross-coupling reactions using triorganoindium reagents. This methodology, being efficient and versatile, allowed the synthesis of a variety of non-symmetrical pyrimidines functionalized at C-4 and C-6 positions.
Departamento de Química Fundamental, Universidade da Coruña, E-15071 A Coruña, Spain. mmartinezc@udc.es
M Montserrat
MM
Martínez
Cristina
C
Pérez-Caaveiro
Miguel
M
Peña-López
Luis A
LA
Sarandeses
José
J
Pérez Sestelo
D060326:Chemistry Techniques, Synthetic; D007204:Indium / Q000737:chemistry*; D009942:Organometallic Compounds / Q000737:chemistry*; D010165:Palladium / Q000737:chemistry; D011743:Pyrimidines / Q000138:chemical synthesis* / Q000737:chemistry*; D013379:Substrate Specificity
D009942:Organometallic Compounds; D011743:Pyrimidines; D007204:Indium; D010165:Palladium