Helicobacter pylori in gastric malignancies.
Helicobacter pylori infection remains common worldwide and is significantly associated with gastric adenocarcinoma and gastric mucosa-associated lymphoid tissue (MALT)lymphoma. This article reviews recent developments in the field of H. pylori with an emphasis on mechanisms of carcinogenesis, and the bacterial, environmental and host factors that may alter risk of developing gastric cancer or gastric MALT lymphoma. The topic of eradication of H. pylori to prevent the development of malignancy and the possibility of a vaccine against H. pylori are also explored.
Department of Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093-0063, USA. abbhandari2@ad.ucsd.edu
Abhishek
A
Bhandari
Sheila E
SE
Crowe
D000230:Adenocarcinoma / Q000150:complications / Q000382:microbiology* / Q000473:pathology; D002471:Cell Transformation, Neoplastic / Q000473:pathology*; D016481:Helicobacter Infections / Q000150:complications* / Q000473:pathology / Q000503:physiopathology; D016480:Helicobacter pylori; D006801:Humans; D018442:Lymphoma, B-Cell, Marginal Zone / Q000150:complications / Q000382:microbiology* / Q000473:pathology; D012307:Risk Factors; D013274:Stomach Neoplasms / Q000382:microbiology*