Docosahexaenoic fatty acid (DHA) in the regulation of colon cell growth and cell death: a review.
BACKGROUND
Experimental, epidemiological and clinical data substantiate the beneficial role of n-3 polyunsaturated fatty acids (PUFAs) in preventing inflammation and cancer of the colon. This review covers the unsaturated docosahexaenoic fatty acid (DHA), describes some of its important cellular and molecular mechanisms, its interaction with another dietary lipid, butyrate and with endogenous apoptotic regulators of the tumour necrosis factor (TNF) family. We also discuss the clinical impact of this knowledge and the use of these lipids in colon cancer prevention and treatment.


RESULTS
From the literature, DHA has been shown to suppress the growth, induce apoptosis in colon cancer cells in vitro and decrease the incidence and growth of experimental tumours in vivo. Based on these data and our own experimental results, we describe and discuss the possible mechanisms of DHA anticancer effects at various levels of cell organization.  We show that DHA can sensitize colon cancer cells to other chemotherapeutic/chemopreventive agents and affect the action of physiological apoptotic regulators of the TNF family.


CONCLUSIONS
Use of n-3 PUFAs could be a relatively non-toxic form of supportive therapy for improving colon cancer treatment and slowing down or preventing its recurrence. However, it is necessary to use them with caution, based on solid scientific evidence of their mechanisms of action from the molecular to the cellular and organism levels.
Department of Cytokinetics, Institute of Biophysics, Academy of Sciences of the Czech Republic, v.v.i. Brno, Czech Republic.
Belma
B
Skender
Alena Hyrslova
AH
Vaculova
Jirina
J
Hofmanova
D000970:Antineoplastic Agents / Q000494:pharmacology*; D017209:Apoptosis / Q000187:drug effects*; D049109:Cell Proliferation / Q000187:drug effects*; D003106:Colon / Q000166:cytology* / Q000187:drug effects; D003110:Colonic Neoplasms / Q000473:pathology; D004281:Docosahexaenoic Acids / Q000494:pharmacology* / Q000502:physiology; D006801:Humans
D000970:Antineoplastic Agents; D004281:Docosahexaenoic Acids