Synthesis and in vitro antimicrobial study of 4-thiazolidinone containing sulfanilamide.
The title compounds, 3-allyl-2-sulfanylamido-4-thiazolidinones (2a-d), have been synthesized after substitution of amino group of sulfanylamide with allylisothiocyanate and cyclization into 4-thiazolidinones. The synthesized compounds were tested for their antibacterial and antifungal activity (MIC) in vitro) against microorganisms: S. aureus, E. faecalis. E. coli, P. aeruginosa, K. pneumoniae, P. mirabilis, B. subtilis, B. cereus and C. albicans taking sulfadimidine, sulfathiazole, sulfanilamide and sulfamethizole as standard drugs. Synthesized compounds (2a-d) demonstrated selective activity against B. cereus.
Department of Analytical and Toxicological Chemistry, Lithuanian University of Health Sciences, Kaunas, Lithuania. augustazev@gmail.com
Augusta
A
Zevzikoviene
Andrejus
A
Zevzikovas
Eduardas
E
Tarasevicius
Alvydas
A
Pavlonis
Vidmantas
V
Dirse
D000890:Anti-Infective Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects; D005658:Fungi / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D013424:Sulfanilamides / Q000138:chemical synthesis* / Q000494:pharmacology*; D053778:Thiazolidines / Q000138:chemical synthesis* / Q000494:pharmacology*
D000890:Anti-Infective Agents; D013424:Sulfanilamides; D053778:Thiazolidines