A molecular link between mitochondrial preprotein transporters and respiratory chain complexes.
The TIM17:23 complex on the mitochondrial inner membrane is responsible for import of the majority of mitochondrial proteins in plants. In Arabidopsis, Tim17 and Tim23 belong to a large gene family consisting of 16 members termed the Preprotein and Amino acid transporters (PRAT). Recently, two members of this protein family, Tim23-2 and the Complex I subunit B14.7, have been shown to assemble into both Complex I of the respiratory chain and the TIM17:23 complex (Wang et al., 2012), adding to other examples of links between respiratory and protein import complexes. These associations provide a mechanism to coordinate mitochondrial activity and biogenesis.
ARC Centre of Excellence in Plant Energy Biology, University of Western Australia, Crawley, WA, Australia. monika.murcha@uwa.edu.au
Monika W
MW
Murcha
Yan
Y
Wang
James
J
Whelan
D029681:Arabidopsis Proteins / Q000235:genetics / Q000378:metabolism; D001692:Biological Transport / Q000235:genetics / Q000502:physiology; D004579:Electron Transport / Q000235:genetics / Q000502:physiology*; D026901:Membrane Transport Proteins / Q000235:genetics / Q000378:metabolism; D033681:Mitochondrial Membrane Transport Proteins / Q000235:genetics / Q000378:metabolism*; D000090622:Mitochondrial Precursor Protein Import Complex Proteins; D010940:Plant Proteins / Q000235:genetics / Q000378:metabolism*
D029681:Arabidopsis Proteins; D026901:Membrane Transport Proteins; D033681:Mitochondrial Membrane Transport Proteins; D000090622:Mitochondrial Precursor Protein Import Complex Proteins; D010940:Plant Proteins; C501430:TIM17 protein, Arabidopsis; C576572:TIM23-2 protein, Arabidopsis