Rapid on-site evaluation increases endoscopic ultrasound-guided fine-needle aspiration adequacy for pancreatic lesions.
BACKGROUND
Rapid on-site evaluation (ROSE) has the potential to improve adequacy rates and affect other outcomes; however, there have been few comparative studies to assess the impact of ROSE in the setting of ultrasound-guided endoscopic fine-needle aspiration cytology for pancreatic lesions.


OBJECTIVE
To determine whether ROSE improves adequacy rates of endoscopic fine-needle aspiration cytology for pancreatic lesions.


METHODS
Systematic review and meta-analysis of studies reporting a head-to-head comparison of adequacy or diagnostic accuracy (with ROSE vs. without ROSE) at a single site.


RESULTS
ROSE was associated with a statistically significant (p < 0.001) improvement in the adequacy rate (average 10 %, 95 % CI: 5-24 %). The impact of ROSE depends on the per-pass adequacy rate without ROSE. ROSE had no impact on diagnostic yield (p < 0.76).


CONCLUSIONS
ROSE is associated with an improvement in adequacy rates when implemented at sites where the per-case adequacy rate without ROSE is low (<90 %). It is unclear whether the type of assessor (pathologist vs. non-pathologist) has a significant impact on the success rate of ROSE. ROSE has no impact on diagnostic yield. Studies should employ head-to-head comparisons of cohorts with and without ROSE at a single location.
Department of Pathology, University of Utah School of Medicine, Salt Lake City, UT, USA. robert.schmidt@hsc.utah.edu
Robert L
RL
Schmidt
Benjamin L
BL
Witt
Anna P
AP
Matynia
Gonzalo
G
Barraza
Lester J
LJ
Layfield
Douglas G
DG
Adler
D061765:Endoscopic Ultrasound-Guided Fine Needle Aspiration; D006801:Humans; D010182:Pancreatic Diseases / Q000175:diagnosis* / Q000473:pathology*; D013997:Time Factors