Risk and prognostic significance of metachronous contralateral testicular germ cell tumours.
BACKGROUND
Testicular germ cell tumour (TGCT) patients are at increased risk of developing a contralateral testicular germ cell tumour (CTGCT). It is unclear whether TGCT treatment affects CTGCT risk.


METHODS
The risk of developing a metachronous CTGCT (a CTGCT diagnosed ≥6 months after a primary TGCT) and its impact on patient's prognosis was assessed in a nationwide cohort comprising 3749 TGCT patients treated in the Netherlands during 1965-1995. Standardised incidence ratios (SIRs), comparing CTGCT incidence with TGCT incidence in the general population, and cumulative CTGCT incidence were estimated and CTGCT risk factors assessed, accounting for competing risks.


RESULTS
Median follow-up was 18.5 years. Seventy-seven metachronous CTGCTs were diagnosed. The SIR for metachronous CTGCTs was 17.6 (95% confidence interval (95% CI) 13.9-22.0). Standardised incidence ratios remained elevated for up to 20 years, while the 20-year cumulative incidence was 2.2% (95% CI 1.8-2.8%). Platinum-based chemotherapy was associated with a lower CTGCT risk among non-seminoma patients (hazard ratio 0.37, 95% CI 0.18-0.72). The CTGCT patients had a 2.3-fold (95% CI 1.3-4.1) increased risk to develop a subsequent non-TGCT cancer and, consequently, a 1.8-fold (95% CI 1.1-2.9) higher risk of death than patients without a CTGCT.


CONCLUSIONS
The TGCT patients remain at increased risk of a CTGCT for up to 20 years. Treatment with platinum-based chemotherapy reduces this risk.
Department of Psychosocial Research and Epidemiology, the Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands.
M
M
Schaapveld
A W
AW
van den Belt-Dusebout
J A
JA
Gietema
R
R
de Wit
S
S
Horenblas
J A
JA
Witjes
H J
HJ
Hoekstra
L A L M
LA
Kiemeney
W J
WJ
Louwman
G M
GM
Ouwens
B M P
BM
Aleman
F E
FE
van Leeuwen
D000328:Adult; D000368:Aged; D015331:Cohort Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D009373:Neoplasms, Germ Cell and Embryonal / Q000453:epidemiology* / Q000473:pathology / Q000628:therapy; D016609:Neoplasms, Second Primary / Q000453:epidemiology* / Q000473:pathology; D011379:Prognosis; D012307:Risk Factors; D016019:Survival Analysis; D013736:Testicular Neoplasms / Q000453:epidemiology* / Q000473:pathology / Q000628:therapy