Modulation of the current signatures of DNA abasic site adducts in the α-hemolysin ion channel.
Electrical current signatures of DNA adducts were investigated during immobilization of strands inside the membrane-bound α-hemolysin ion channel. The current blockages produced by these adducts were found to depend on both size and shape, providing insights into the DNA-protein interactions and the size limitation of bulky adducts to be translocated.
Department of Chemistry, University of Utah, Salt Lake City, USA.
Na
N
An
Henry S
HS
White
Cynthia J
CJ
Burrows
D001483:Base Sequence; D018736:DNA Adducts / Q000737:chemistry* / Q000235:genetics / Q000378:metabolism*; D004553:Electric Conductivity; D006460:Hemolysin Proteins / Q000378:metabolism*; D007473:Ion Channels / Q000378:metabolism*
D018736:DNA Adducts; D006460:Hemolysin Proteins; D007473:Ion Channels