Layered double hydroxides as efficient drug delivery system of ciprofloxacin in the middle ear: an animal study in rabbits.
Chronic otitis media is a common disease often accompanied by recurrent bacterial infections. These may lead to the destruction of the middle ear bones such that prostheses have to be implanted to restore sound transmission. Surface coatings with layered double hydroxides (LDHs) are evaluated here as a possibility for drug delivery systems with convenient advantages such as low cytotoxicity and easy synthesis. Male New Zealand White rabbits were implanted with Bioverit(®) II middle ear prostheses coated with the LDH Mg(4)Al(2)(OH)(12)(SO(4))(2)·6H(2)O impregnated with ciprofloxacin. 12 (group 1) were directly infected with Pseudomonas aeruginosa and another 12 (group 2) 1 week after the implantation. Clinical outcome, blood counts, histological analyses and microbiological examination showed an excellent antimicrobial activity for group 1, whereas this effect was attenuated in animals where infection was performed 1 week after implantation. This is the first study to demonstrate an efficient drug delivery system with an LDH coating on prostheses in the middle ear.
ENT Department, Hannover Medical School, Hannover, Germany.
Daniela
D
Hesse
Muhammad
M
Badar
André
A
Bleich
Anna
A
Smoczek
Silke
S
Glage
Marc
M
Kieke
Peter
P
Behrens
Peter Paul
PP
Müller
Karl-Heinz
KH
Esser
Martin
M
Stieve
Nils Kristian
NK
Prenzler
D000818:Animals; D000900:Anti-Bacterial Agents / Q000008:administration & dosage* / Q000627:therapeutic use; D002939:Ciprofloxacin / Q000008:administration & dosage* / Q000627:therapeutic use; D016503:Drug Delivery Systems; D004432:Ear, Middle / Q000378:metabolism*; D006878:Hydroxides / Q000737:chemistry*; D008297:Male; D011552:Pseudomonas Infections / Q000188:drug therapy*; D011817:Rabbits
D000900:Anti-Bacterial Agents; D006878:Hydroxides; D002939:Ciprofloxacin