Expression of Cyclin D1 Is Associated with β-Catenin Expression and Correlates with Good Prognosis in Colorectal Adenocarcinoma.
BACKGROUND
The aim of this study is to investigate the prevalence and prognostic impact of β-catenin and cyclin D1 expression in colorectal carcinoma (CRC) patients.


METHODS
We evaluated immunohistochemial expression of β-catenin and cyclin D1 using 2-mm cores from 220 CRC patients for tissue microarray, and its significance was statistically evaluated.


RESULTS
Positive expression of β-catenin and cyclin D1 was found in 72.5% (158 of 218 cases) and 59.4% (129 of 217 cases) of CRC patients, respectively. Expression of β-catenin was significantly correlated with tumor location (P = .017), differentiation (P = .010), lymph node metastasis (P = .032), preoperative carcinoembryonic antigen level (P = .032), and cyclin D1 expression (P = .005). Expression of cyclin D1 was significantly correlated with recurrence and/or metastasis (P = .004). In univariate analysis, β-catenin expression predicted more favorable overall survival (P = .022) and cyclin D1 expression predicted both more favorable overall survival and relapse-free survival (P = .004 and P = .006, respectively). Multivariate analysis showed that tumor stage and expression of cyclin D1 were independent prognostic factors significantly associated with overall survival and relapse-free survival.


CONCLUSIONS
This study shows that expression of β-catenin and cyclin D1 is associated with favorable clinicopathologic variables and it is a clinically significant prognostic indicator for CRC patients.
Department of Pathology, Chonbuk National University Medical School, Jeonju, Republic of Korea ; Research Institute for Endocrine Sciences, Chobnuk National University, Jeonju, Republic of Korea ; Research Institute of Clinical Medicine, Chonbuk National University Hospital, Chonbuk National University, Jeonju, Republic of Korea.
Kyu Yun
KY
Jang
Yo Na
YN
Kim
Jun Sang
JS
Bae
Myoung Ja
MJ
Chung
Woo Sung
WS
Moon
Myoung Jae
MJ
Kang
Dong Geun
DG
Lee
Ho Sung
HS
Park