Association of p53 Arg72Pro polymorphism with bladder cancer: a meta-analysis.
BACKGROUND
p53 tumor suppressor gene Arg72Pro polymorphism has been associated with bladder cancer. However, results were inconsistent. We performed this meta-analysis to estimate the association between p53 Arg72Pro polymorphism and bladder cancer.


METHODS
Electronic search of PubMed was conducted to select studies. Studies containing available genotype frequencies of Arg72Pro were chosen, and pooled odds ratio (OR) with 95% confidence interval (CI) was used to assess the association.


RESULTS
The final meta-analysis included 14 published studies with 2176 bladder cancer cases and 2798 controls. The results suggested that the variant genotype was associated with the bladder cancer risk (additive model: OR=1.72, 95% CI: 1.036-1.325, P=0.011; dominant model: OR=1.268, 95% CI: 1.003-1.602, P=0.047) in Asian subgroup. However, the association was not significant between this polymorphism and bladder cancer risk in Caucasian (additive model: OR=0.773, 95% CI: 0.564-1.059, P=0.109; dominant model: OR=0.685, 95% CI: 0.418-1.124, P=0.134).


CONCLUSIONS
This meta-analysis suggests that p53 Arg72Pro polymorphism is associated with increased risk of bladder cancer in Asians. To validate the association between this polymorphism and bladder cancer, further studies with larger participants worldwide are needed.
School of Life Science, Yunnan University, Kunming, Yunnan, China.
Zhili
Z
Yang
Shengjie
S
Nie
Hui
H
Zhu
Xiaoming
X
Wu
Shuting
S
Jia
Ying
Y
Luo
Wenru
W
Tang
D019943:Amino Acid Substitution; D044466:Asian People / Q000235:genetics; D005260:Female; D006801:Humans; D008297:Male; D008957:Models, Genetic; D020125:Mutation, Missense; D011110:Polymorphism, Genetic; D012307:Risk Factors; D016159:Tumor Suppressor Protein p53 / Q000235:genetics* / Q000378:metabolism; D001749:Urinary Bladder Neoplasms / Q000453:epidemiology / Q000208:ethnology / Q000235:genetics* / Q000378:metabolism; D044465:White People / Q000235:genetics
C495901:TP53 protein, human; D016159:Tumor Suppressor Protein p53