Role of TNF-alpha as a survival prognostic marker in chronic lymphocytic leukemia patients.
Pro-inflammatory cytokines play a central role in the pathogenesis of chronic leukemia. This pilot study assesses the potential value of measuring TNF-alpha, IL-6, IL-18 and CRP levels as prognostic markers for disease monitoring in CLL patient. These parameters were evaluated in 45 CLL patients and 25 healthy control subjects IL-6 on contraire to the other cytokines, was significantly higher (P<0.05) in patients compared to controls. At hematological remission, only CRP was significantly reduced (P<0.005). IL-6 is inversely correlated with Hb (P<0.05). In the meantime, IL-18 is correlated to splenomegaly, and CRP (P<0.05; for both). TNF-alpha level in non-survived patients was significantly higher than both survived patients (P<0.05), and controls (P<0.01). In conclusion, TNF-alpha can be potentially used as a survival prognostic factor in CLL.
Clinical Pathology Department, National Cancer Institute, Cairo University, Cairo, Egypt.
M K
MK
Singer
M
M
Assem
A B
AB
Abdel Ghaffar
N Y
NY
Morcos
D000328:Adult; D000368:Aged; D000970:Antineoplastic Agents / Q000627:therapeutic use; D014408:Biomarkers, Tumor / Q000097:blood*; D002097:C-Reactive Protein / Q000378:metabolism*; D005260:Female; D006801:Humans; D020382:Interleukin-18 / Q000097:blood*; D015850:Interleukin-6 / Q000097:blood*; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000097:blood* / Q000188:drug therapy; D008297:Male; D008875:Middle Aged; D010865:Pilot Projects; D011237:Predictive Value of Tests; D012372:ROC Curve; D016019:Survival Analysis; D014409:Tumor Necrosis Factor-alpha / Q000097:blood*
D000970:Antineoplastic Agents; D014408:Biomarkers, Tumor; D020382:Interleukin-18; D015850:Interleukin-6; D014409:Tumor Necrosis Factor-alpha; D002097:C-Reactive Protein