Increasing the heme-dependent respiratory efficiency of Lactococcus lactis by inhibition of lactate dehydrogenase.
The discovery of heme-induced respiration in Lactococcus lactis has radically improved the industrial processes used for the biomass production of this species. Here, we show that inhibition of the lactate dehydrogenase activity of L. lactis during growth under respiration-permissive conditions can stimulate aerobic respiration, thereby increasing not only growth efficiency but also the robustness of this organism.
Department of Food, Nutritional and Environmental Sciences, University of Milan, Italy.
Stefania
S
Arioli
Daniele
D
Zambelli
Simone
S
Guglielmetti
Ivano
I
De Noni
Martin B
MB
Pedersen
Per Dedenroth
PD
Pedersen
Fabio
F
Dal Bello
Diego
D
Mora
D018533:Biomass; D006418:Heme / Q000378:metabolism*; D007770:L-Lactate Dehydrogenase / Q000037:antagonists & inhibitors*; D013294:Lactococcus lactis / Q000201:enzymology* / Q000254:growth & development / Q000378:metabolism*; D010084:Oxidation-Reduction
D006418:Heme; D007770:L-Lactate Dehydrogenase