Association of PON1 and PON2 polymorphisms with PON1 activity and significant coronary stenosis in a Tunisian population.
PON1 and PON2 have attracted considerable attention as candidate genes for coronary heart disease because their enzymes function as key factors in lipoprotein catabolism pathways. We studied the distribution of PON1 and PON2 polymorphisms, including genotyping, lipid profile, and PON1 activity, and their association with PON1 activity and significant coronary stenosis (SCS) in a Tunisian population. PON1 activity was lower in patients with SCS than in controls. It increased with the R allele (QQ < QR < RR) in PON1-192 genotypes and with the L allele (MM < ML < LL) in PON1-55 genotypes. In the presence of metabolic syndrome and diabetes, PON1-192RR and PON2-311CC were associated with an increased risk of SCS and PON1-55MM seems to have lower risk. This association was evident among nonsmokers for PON1-55MM and among smokers for PON1-192RR and PON2-311CC. The GTGC haplotype seemed to increase the risk of SCS compared with the wild haplotype in a Tunisian population.
Department of Biochemistry, UR MSP 28/04, Sahloul University Hospital, 4054, Sousse, Tunisia.
Jihène
J
Rejeb
Asma
A
Omezzine
Lamia
L
Rebhi
Imen
I
Boumaiza
Hajer
H
Mabrouk
Hamida
H
Rhif
Nabila Ben
NB
Rejeb
Naoufel
N
Nabli
Wahiba
W
Douki
Ahmed Ben
AB
Abdelaziz
Essia
E
Boughzala
Ali
A
Bouslama
D000328:Adult; D000368:Aged; D043303:Aryldialkylphosphatase / Q000235:genetics*; D001483:Base Sequence; D023921:Coronary Stenosis / Q000201:enzymology* / Q000235:genetics; D017931:DNA Primers; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D014416:Tunisia
D017931:DNA Primers; D043303:Aryldialkylphosphatase; C468406:PON1 protein, human; C468411:PON2 protein, human