Functional network analysis with the subcellular location and gene ontology information in human allergic asthma.
Asthma is a chronic inflammatory disease characterized by airway hyperresponsiveness, tissue remodeling, and airflow obstruction. The pathogenesis of asthma is only partly understood, and there is an urgent need for improved therapeutic strategies for this disease. The protein-protein interaction (PPI) network has considerable promise as a tool for discovery of novel asthma therapeutic targets and their relationship. Among the genes that have been identified by PPI studies, APP, CDKN1B, and SP3 displayed up-regulated expression. Further study depicted that CDKN1B localized in the nucleus or cytoplasm could interact with GRB2 and CASP8, but SP3 localized in the nucleus could interact with histone deacetylase 1, SP1, and E2F1. We anticipate that these types of analyses will provide considerable insight into asthma pathogenesis and will provide a wealth of new molecules for downstream analyses.
Wuhan General Hospital Guangzhou Military Region, Wuhan, China.
Bo
B
Diao
Ying
Y
Liu
Yi
Y
Zhang
Qin
Q
Liu
Wen-Jie
WJ
Lu
GuoZheng
G
Xu
D001249:Asthma / Q000235:genetics*; D020869:Gene Expression Profiling; D006801:Humans; D020411:Oligonucleotide Array Sequence Analysis; D060066:Protein Interaction Maps