MicroRNA-target interactions: new insights from genome-wide approaches.
MicroRNAs (miRNAs) are key posttranscriptional regulators of gene expression involved in diverse biological pathways in bilateral animals and plants. The key to understanding the biological function of a miRNA is to identify its regulatory targets. Although a few miRNA targets have been identified genetically, the rapidly expanding list of miRNAs has necessitated genome-wide tools for identifying target mRNAs, and a number of computational and experimental approaches have consequently emerged. Some of these approaches have also provided insights into the mechanistic aspects of miRNA-mediated regulation, another intensely debated area in the miRNA field. Here, we review several emerging features of miRNA-target interactions in animals and genome-wide approaches for probing those interactions.
Department of Agricultural Biotechnology, Seoul National University, Seoul, Republic of Korea.
Dooyoung
D
Lee
Chanseok
C
Shin
D000818:Animals; D019295:Computational Biology; D015536:Down-Regulation; D020869:Gene Expression Profiling; D005786:Gene Expression Regulation; D055106:Genome-Wide Association Study; D006801:Humans; D035683:MicroRNAs / Q000378:metabolism*; D009928:Organ Specificity; D012333:RNA, Messenger / Q000378:metabolism; D013045:Species Specificity; D015854:Up-Regulation
D035683:MicroRNAs; D012333:RNA, Messenger