HSP90, HSPA8, HIF-1 alpha and HSP70-2 polymorphisms in breast cancer: a case-control study.
This case control study aims to investigate the role of HSP90 Gln488His (C > G), HSP70-2 P1/P2, HIF-1 alpha C1772T and HSPA8 intronic 1541-1542delGT polymorphisms as potential risk factors and/or prognostic markers for breast cancer. 113 consecutive incident cases of histologically confirmed ductal breast cancer and 124 healthy cases were recruited. The above mentioned polymorphisms were genotyped; multivariate logistic regression was performed. HSP90 GG (His/His) genotype was associated with elevated breast cancer risk. Similarly, the allele dose-response model pointed to increase in breast cancer risk per G allele. HSP70-2 P1/P2, HSPA8 intronic 1541-1542delGT and HIF-1 alpha polymorphisms were not associated with breast cancer risk, as evidenced by the dose-response allele models. The positive association between HSP90 G allele and breast cancer risk seemed to pertain to both premenopausal and postmenopausal women. With respect to survival analysis, none of the aforementioned polymorphisms was associated with either disease-free survival or overall survival. HSP90α Gln488His polymorphism seems to be a risk factor for breast cancer. On the other hand, our study did not point to excess risk conferred by HSPA8 1541-1542delGT, Hsp70-2 P1/P2 and HIF-1α C1772T.
Department of Clinical Therapeutics, Alexandra Hospital, University of Athens, Athens, Greece.
Flora
F
Zagouri
Theodoros N
TN
Sergentanis
Maria
M
Gazouli
Alexandra
A
Tsigginou
Constantine
C
Dimitrakakis
Irene
I
Papaspyrou
Evaggelos
E
Eleutherakis-Papaiakovou
Dimosthenis
D
Chrysikos
George
G
Theodoropoulos
George C
GC
Zografos
Aris
A
Antsaklis
Athanassios-Meletios
AM
Dimopoulos
Christos A
CA
Papadimitriou
D001943:Breast Neoplasms / Q000235:genetics*; D016022:Case-Control Studies; D003710:Demography; D005260:Female; D005787:Gene Frequency / Q000235:genetics; D050883:HSC70 Heat-Shock Proteins / Q000235:genetics*; D018840:HSP70 Heat-Shock Proteins / Q000235:genetics*; D018841:HSP90 Heat-Shock Proteins / Q000235:genetics*; D006801:Humans; D051795:Hypoxia-Inducible Factor 1, alpha Subunit / Q000235:genetics*; D053208:Kaplan-Meier Estimate; D008875:Middle Aged; D016017:Odds Ratio; D011110:Polymorphism, Genetic; D016016:Proportional Hazards Models; D012044:Regression Analysis
C497442:HIF1A protein, human; D050883:HSC70 Heat-Shock Proteins; D018840:HSP70 Heat-Shock Proteins; D018841:HSP90 Heat-Shock Proteins; C112969:HSP90AA1 protein, human; C525621:HSPA1B protein, human; C494371:HSPA8 protein, human; D051795:Hypoxia-Inducible Factor 1, alpha Subunit