Immunoexpression of type-1 adiponectin  receptor in the human intestine.
Adiponectin is an important biomarker of metabolic syndrome that was recently identified in human breast milk. We demonstrate the presence of type-1 adiponectin receptor (adipoR1) by immunoperoxidase method in 21 bioptic specimens - duodenum (n = 6), terminal ileum (n = 7) and colon (n = 8) from 14 human subjects (6 females and 8 males aged 9 months-47 years). In all the samples, adipoR1 was detected. The positivity was observed in enterocytes and colonocytes as well as in lymphocytes in the submucosa and in the smooth muscle of the intestinal wall. Thus, adiponectin may influence intestinal physiology through its type-1 receptor.


BACKGROUND
adiponectin - adiponectin receptor - intestine - nutritional programming - breast milk.
J
J
Bronský
K
K
Mitrová
J
J
Nevoral
J
J
Zámečník
D003106:Colon; D006801:Humans; D012333:RNA, Messenger; D054419:Receptors, Adiponectin
D012333:RNA, Messenger; D054419:Receptors, Adiponectin