Ethanol consumption impairs the hemodynamic response to hemorrhagic shock in rats.
Alcohol intoxication can exacerbate hemodynamic instability following hemorrhagic shock. Impairment of hormonal, neurohumoral, and immune responses can contribute to such instability; however, the relationship between blood alcohol levels and the progression of hemorrhagic shock accompanied with these responses has not been clearly demonstrated. Herein, we examined this relationship in rats treated with various dose of alcohol. After oral administration of alcohol and then hemorrhage, the recovery of mean blood pressure (MBP); increase in plasma level of norepinephrine, epinephrine, and vasopressin; and survival interval decreased in a dose-dependent manner as the blood alcohol level increased. There were no significant differences in the production of proinflammatory cytokines such as tumor necrosis factor (TNF)-α and interleukin (IL)-1β among the groups. The present results demonstrated alcohol aggravates hemorrhagic shock in a dose-dependent manner not by alerting the immune response, but by suppressing hormonal and neurohumoral responses, thereby inhibiting hemodynamic autoregulation and shortening the survival interval.
Department of Forensic Medicine, School of Medicine, University of Occupational and Environmental Health, Iseigaoka1-1, Yahata-Nishi, Kitakyushu 807-8555, Japan. h-sato@med.uoeh-u.ac.jp
Hiroaki
H
Sato
Toshiko
T
Tanaka
Kentaro
K
Kasai
D000818:Animals; D001127:Arginine Vasopressin / Q000097:blood; D001794:Blood Pressure / Q000187:drug effects; D004837:Epinephrine / Q000097:blood; D000431:Ethanol / Q000494:pharmacology*; D006439:Hemodynamics / Q000187:drug effects*; D053583:Interleukin-1beta / Q000097:blood; D008297:Male; D009638:Norepinephrine / Q000097:blood; D051381:Rats; D017208:Rats, Wistar; D012771:Shock, Hemorrhagic / Q000097:blood / Q000503:physiopathology*; D014409:Tumor Necrosis Factor-alpha / Q000097:blood
D053583:Interleukin-1beta; D014409:Tumor Necrosis Factor-alpha; D001127:Arginine Vasopressin; D000431:Ethanol; D009638:Norepinephrine; D004837:Epinephrine