Association between CD14 gene C-260T polymorphism and inflammatory bowel disease: a meta-analysis.
BACKGROUND
The gene encoding CD14 has been proposed as an IBD-susceptibility gene with its polymorphism C-260T being widely evaluated, yet with conflicting results. The aim of this study was to investigate the association between this polymorphism and IBD by conducting a meta-analysis.


RESULTS
Seventeen articles met the inclusion criteria, which included a total of 18 case-control studies, including 1900 ulcerative colitis (UC) cases, 2535 Crohn's disease (CD) cases, and 4004 controls. Data were analyzed using STATA software. Overall, association between C-260T polymorphism and increased UC risk was significant in allelic comparison (odds ratio [OR]  =1.21, 95% confidence interval [CI]: 1.02-1.43; P=0.027), homozygote model (OR  =1.44, 95% CI: 1.03-2.01; P=0.033), as well as dominant model (OR  =1.36, 95% CI: 1.06-1.75; P=0.016). However, there was negative association between this polymorphism and CD risk across all genetic models. Subgroup analyses by ethnicity suggested the risk-conferring profiles of -260T allele and -260 TT genotype with UC in Asians, but not in Caucasians. There was a low probability of publication bias.


CONCLUSIONS
Expanding previous results of individual studies, our findings demonstrated that CD14 gene C-260T polymorphism might be a promising candidate marker in susceptibility to UC, especially in Asians.
Department of Gastroenterology, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.
Zhengting
Z
Wang
Jiajia
J
Hu
Rong
R
Fan
Jie
J
Zhou
Jie
J
Zhong
D000483:Alleles; D044466:Asian People; D016022:Case-Control Studies; D003093:Colitis, Ulcerative / Q000208:ethnology* / Q000235:genetics*; D003424:Crohn Disease / Q000208:ethnology* / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D005799:Genes, Dominant; D020022:Genetic Predisposition to Disease; D006720:Homozygote; D006801:Humans; D018950:Lipopolysaccharide Receptors / Q000235:genetics*; D008297:Male; D008957:Models, Genetic; D020641:Polymorphism, Single Nucleotide; D044465:White People
D018950:Lipopolysaccharide Receptors