Candidate genes for production traits in Nelore beef cattle.
Meat quality is an important trait for the beef  industry. Backfat thickness, ribeye area, and shear force are traits measured  late in life, and the investigation of molecular markers associated with these  traits can help breeding programs. In cattle, some polymorphisms have been  related to production traits. Thus, the purpose of this study was to assess the  presence of polymorphisms in the candidate genes insulin-like growth factor 1 (IGF1),  fatty acid-binding protein 4 (FABP4), and peroxisome proliferative  active receptor gamma coactivator 1 A (PPARGC1A) and associate them with  production traits in reference families of Nelore cattle. We used 270 steers  descendent from 20 sires that were chosen to represent variability in this  breed. The investigation of marker effects on the traits was performed using a  mixed model under the restricted maximum likelihood method. A significant  allele substitution effect was found for IGF1 and yearling weight (P ≤  0.017). The mean allele substitution effect was 6.9 kg, with the 229 allele  associated with reduced yearling weight in this Nelore population.
Departamento de Genética e Evolução, Universidade Federal de São Carlos, São Carlos, SP, Brasil.
P C
PC
Tizioto
S L
SL
Meirelles
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RR
Tulio
A N
AN
Rosa
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MM
Alencar
S R
SR
Medeiros
F
F
Siqueira
G L D
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Feijó
L O C
LO
Silva
R A A
RA
Torres Junior
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Regitano
D000818:Animals; D001835:Body Weight / Q000235:genetics; D002417:Cattle / Q000033:anatomy & histology / Q000235:genetics*; D050556:Fatty Acid-Binding Proteins / Q000235:genetics*; D063427:Food Quality; D005787:Gene Frequency; D056726:Genetic Association Studies; D005819:Genetic Markers; D007334:Insulin-Like Growth Factor I / Q000235:genetics*; D016013:Likelihood Functions; D008297:Male; D008460:Meat; D008957:Models, Genetic; D020641:Polymorphism, Single Nucleotide; D040641:Quantitative Trait Loci; D050151:Subcutaneous Fat / Q000033:anatomy & histology; D014157:Transcription Factors / Q000235:genetics*
D050556:Fatty Acid-Binding Proteins; D005819:Genetic Markers; D014157:Transcription Factors; D007334:Insulin-Like Growth Factor I