Anisomycin infusions in the parabrachial nucleus and taste neophobia.
To investigate whether de novo protein synthesis in the parabrachial nucleus (PBN) is required for recovery from taste neophobia, anisomycin (a protein synthesis inhibitor) was infused immediately after consumption of a novel saccharin solution (Experiment 1). Unexpectedly, this PBN treatment caused a reduction in saccharin intake. In addition, we found that the anisomycin-induced suppression of tastant intake was attenuated by prior intra-PBN infusions of lidocaine (Experiment 2). This pattern of results raises concerns about using anisomycin to investigate memory consolidation processes in the PBN. Thus, a different manipulation may be needed to examine the nature of the neuroplastic changes that occur in the PBN during taste memory formation.
Department of Psychology, University of Illinois at Chicago, Chicago, IL 60607, USA. jlin2@uic.edu
Jian-You
JY
Lin
Leslie Renee
LR
Amodeo
Joe
J
Arthurs
Steve
S
Reilly
D000704:Analysis of Variance; D000779:Anesthetics, Local / Q000494:pharmacology; D000818:Animals; D000841:Anisomycin / Q000494:pharmacology*; D001245:Association Learning / Q000187:drug effects*; D001362:Avoidance Learning / Q000187:drug effects; D003214:Conditioning, Classical / Q000187:drug effects*; D004347:Drug Interactions; D005106:Exploratory Behavior / Q000187:drug effects; D005239:Fear; D005518:Food Preferences; D008012:Lidocaine / Q000494:pharmacology; D011149:Pons / Q000187:drug effects*; D014176:Protein Biosynthesis / Q000187:drug effects / Q000502:physiology; D011500:Protein Synthesis Inhibitors / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D021641:Recognition, Psychology / Q000187:drug effects; D009435:Synaptic Transmission / Q000187:drug effects; D055697:Taste Perception / Q000187:drug effects*
D000779:Anesthetics, Local; D011500:Protein Synthesis Inhibitors; D000841:Anisomycin; D008012:Lidocaine