Kidney pericytes: a novel therapeutic target in interstitial fibrosis.
Chronic Kidney Disease affects approximately 8% of the population and contributes considerably to premature morbidity and mortality. Recently reported studies have highlighted an important role for resident microvascular pericytes in the pathogenesis of kidney fibrosis. Pericytes are emerging as the predominant source of the activated, matrix depositing, stromal cell population seen in progressive fibrosis. Further, pericyte activation leads to their detachment from the vasculature, triggers unstable microvasculature and leads to rarefaction. Strategies to modulate pericyte function in these processes are therefore therapeutically attractive. In this review we will first describe our current understanding of the structure and function of the pericyte and the role these cells play in angiogenesis and the pathogenesis of renal fibrosis. Novel therapeutic approaches targeting pericytes in murine models of renal disease will then be considered.
Renal research group, Institute of Biomedical Research, University of Birmingham, UK.
S W
SW
Smith
C
C
Schrimpf
D J
DJ
Parekh
M
M
Venkatachalam
J S
JS
Duffield
D000818:Animals; D015703:Antigens, CD / Q000235:genetics; D000951:Antigens, Neoplasm / Q000235:genetics; D004195:Disease Models, Animal; D005355:Fibrosis; D055785:Gene Knockdown Techniques; D006801:Humans; D007668:Kidney / Q000098:blood supply / Q000473:pathology / Q000503:physiopathology; D051379:Mice; D055806:Microvessels / Q000473:pathology; D008954:Models, Biological; D058628:Myofibroblasts / Q000473:pathology; D009389:Neovascularization, Pathologic; D020286:Pericytes / Q000473:pathology* / Q000502:physiology; D017479:Receptors, Platelet-Derived Growth Factor / Q000037:antagonists & inhibitors; D051436:Renal Insufficiency, Chronic / Q000473:pathology* / Q000503:physiopathology / Q000628:therapy*; D015398:Signal Transduction
D015703:Antigens, CD; D000951:Antigens, Neoplasm; C078203:CD248 protein, human; D017479:Receptors, Platelet-Derived Growth Factor