Next-generation sequencing in the clinic: are we ready?
We are entering an era in which the cost of clinical whole-genome and targeted sequencing tests is no longer prohibitive to their application. However, currently the infrastructure is not in place to support both the patient and the physicians that encounter the resultant data. Here, we ask five experts to give their opinions on whether clinical data should be treated differently from other medical data, given the potential use of these tests, and on the areas that must be developed to improve patient outcome.
Genetic Disease Research Branch, National Human Genome Research Institute, 49 Convent Drive, Room 4A56, Bethesda, Maryland 20892, USA. lesb@helix.nih.gov
Leslie G
LG
Biesecker
Wylie
W
Burke
Isaac
I
Kohane
Sharon E
SE
Plon
Ron
R
Zimmern
D004992:Ethics, Medical; D005104:Expert Testimony; D005820:Genetic Testing / Q000941:ethics; D015894:Genome, Human / Q000235:genetics*; D006801:Humans; D025202:Molecular Diagnostic Techniques / Q000941:ethics* / Q000379:methods; D009369:Neoplasms / Q000175:diagnosis / Q000235:genetics; D017422:Sequence Analysis, DNA / Q000941:ethics* / Q000379:methods