P53 status as a predictive biomarker for patients receiving neoadjuvant radiation-based treatment: a meta-analysis in rectal cancer.
BACKGROUND
Numerous studies have yielded inconsistent results regarding the relationship between p53 status and the response to neoadjuvant radiation-based therapy in patients with rectal cancer. We conducted a meta-analysis to clarify the relationship between p53 status and response to radiation-based therapy in rectal cancer.


RESULTS
A total of 30 previously published eligible studies including 1,830 cases were identified and included in this meta-analysis. Wild-type form of p53 status (low expression of p53 protein and/or wild-type p53 gene) was associated with pathologic response in rectal cancer patients who received neoadjuvant radiation-based therapy (good response: risk ratio [RR] =1.30; 95% confidence intervals [CI] =1.14-1.49; p<0.001; complete response RR=1.65; 95% CI=1.19-2.30; p=0.003; poor response RR=0.85; 95% CI=0.75-0.96; p=0.007). In further stratified analyses, this association remained for sub-groups of good and poor response in neoadjuvant radiotherapy (RT) setting, good and complete response in chemoradiotherapy (CRT) setting. And the association between response and the presence of p53 gene mutations was stronger than that between response and protein positivity.


CONCLUSIONS
The results of the present meta-analysis indicate that P53 status is a predictive factor for response in rectal cancer patient undergoing neoadjuvant radiation-based therapy.
Department of Medical Oncology, Kunshan First People's Hospital Affiliated to Jiangsu University, Kunshan, Jiangsu Province, People's Republic of China.
Min-Bin
MB
Chen
Xiao-Yang
XY
Wu
Rong
R
Yu
Chen
C
Li
Li-Qiang
LQ
Wang
Wei
W
Shen
Pei-Hua
PH
Lu
D000230:Adenocarcinoma; D000970:Antineoplastic Agents / Q000494:pharmacology / Q000627:therapeutic use*; D015415:Biomarkers / Q000378:metabolism; D059248:Chemoradiotherapy; D005720:Gamma Rays; D015870:Gene Expression / Q000187:drug effects / Q000528:radiation effects; D006801:Humans; D009154:Mutation; D020360:Neoadjuvant Therapy; D060787:Neoplasm Grading; D011379:Prognosis; D012004:Rectal Neoplasms / Q000188:drug therapy / Q000235:genetics* / Q000473:pathology / Q000532:radiotherapy; D016159:Tumor Suppressor Protein p53 / Q000235:genetics* / Q000378:metabolism
D000970:Antineoplastic Agents; D015415:Biomarkers; D016159:Tumor Suppressor Protein p53