Cytotoxic petrosiacetylenes from the marine sponge Petrosia sp.
A novel petrosiacetylene analog (petrosiacetylene E) has been isolated from the Korean marine sponge Petrosia sp., along with petrosiacetylene A, B and C. Their structures were elucidated on the basis of spectroscopic methods and the stereochemistry of the new compound was determined by using the modified Mosher's method. Petrosiacetylene E showed higher cytotoxicity against five human cancer cell lines than petrosiacetylene A and B, presumably due to the additional hydroxy group located at C-16.
Korea Institute of Ocean Science and Technology, Ansan, Republic of Korea. yjlee@kiost.ac
Yeon-Ju
YJ
Lee
Su-Jung
SJ
Yoo
Jong Soon
JS
Kang
Jieun
J
Yun
Hee Jae
HJ
Shin
Jong Seok
JS
Lee
Hyi-Seung
HS
Lee
D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D004354:Drug Screening Assays, Antitumor; D009369:Neoplasms / Q000188:drug therapy; D047130:Petrosia / Q000737:chemistry*; D053279:Polyynes / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*
D000972:Antineoplastic Agents, Phytogenic; D053279:Polyynes