Idiopathic giant oesophageal ulcer and leucopoenia after renal transplantation.
A 45-year-old male recipient of a renal allograft was admitted because of a giant oesophageal ulcer coinciding with leucopoenia. An extensive workup revealed no explanation for the ulcer and leucopoenia. Our final diagnosis by exclusion was an idiopathic giant oesophageal ulcer and late-onset neutropenia as consequences of rituximab induction therapy given during the transplant procedure. The patient fully recovered after treatment with prednisone. However, after four months, the ulcer and leucopoenia recurred and again successfully responded to treatment with prednisone.
Department of Nephrology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands. g.vanboekel@nier.umcn.nl
G A J
GA
van Boekel
M
M
Volbeda
M W F
MW
van den Hoogen
L B
LB
Hilbrands
J H M
JH
Berden
D058846:Antibodies, Monoclonal, Murine-Derived / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D004935:Esophageal Diseases / Q000209:etiology* / Q000473:pathology; D006801:Humans; D007155:Immunologic Factors / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use; D016030:Kidney Transplantation / Q000009:adverse effects*; D007970:Leukopenia / Q000139:chemically induced / Q000188:drug therapy / Q000209:etiology*; D008297:Male; D008875:Middle Aged; D019990:Perioperative Care / Q000009:adverse effects / Q000379:methods; D011241:Prednisone / Q000627:therapeutic use*; D000069283:Rituximab; D014456:Ulcer / Q000139:chemically induced / Q000188:drug therapy / Q000209:etiology*
D058846:Antibodies, Monoclonal, Murine-Derived; D007155:Immunologic Factors; D000069283:Rituximab; D011241:Prednisone