New monoterpene glycosides from Paeonia suffruticosa Andrews and their inhibition on NO production in LPS-induced RAW 264.7 cells.
Nine new monoterpene glycosides (1-9), together with 18 known compounds were obtained from the n-butanol soluble fraction of ethanol extract from Paeonia suffruticosa Andrews. Their structures were determined on the basis of chemical methods and spectroscopic data. The inhibitory effects of these compounds (except compound 6) on nitric oxide (NO) production in lipopolysaccharide-activated macrophages were evaluated. Compounds 1, 21, 23, 25, and 27 showed strong inhibitory activity on NO production with IC(50) values of 31.25, 36.13, 12.41, 6.87, and 41.94 μM, respectively.
Department of Natural Products Chemistry, Shenyang Pharmaceutical University, Shenyang 110016, People's Republic of China.
Liqin
L
Ding
Feng
F
Zhao
Lixia
L
Chen
Zhihu
Z
Jiang
Yue
Y
Liu
Zhuomin
Z
Li
Feng
F
Qiu
Xinsheng
X
Yao
D000818:Animals; D002460:Cell Line; D006027:Glycosides / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D008070:Lipopolysaccharides / Q000633:toxicity; D008264:Macrophages / Q000187:drug effects; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D008968:Molecular Conformation; D039821:Monoterpenes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D009569:Nitric Oxide / Q000378:metabolism*; D029596:Paeonia / Q000737:chemistry*; D018517:Plant Roots / Q000737:chemistry
D006027:Glycosides; D008070:Lipopolysaccharides; D039821:Monoterpenes; D009569:Nitric Oxide