Advanced modality imaging evaluation in acute ischemic stroke may lead to delayed endovascular reperfusion therapy without improvement in clinical outcomes.
OBJECTIVE
Advanced neuroimaging techniques may improve patient selection for endovascular stroke treatment but may also delay time to reperfusion. We studied the effect of advanced modality imaging with CT perfusion (CTP) or MRI compared with non-contrast CT (NCT) in a multicenter cohort.


METHODS
This is a retrospective study of 10 stroke centers who select patients for endovascular treatment using institutional protocols. Approval was obtained from each institution's review board as only de-identified information was used. We collected demographic and radiographic data, selected time intervals, and outcome data. ANOVA was used to compare the groups (NCT vs CTP vs MRI). Binary logistic regression analysis was performed to determine factors associated with a good clinical outcome.


RESULTS
556 patients were analyzed. Mean age was 66 ± 15 years and median National Institutes of Health Stroke Scale score was 18 (IQR 14-22). NCT was used in 286 (51%) patients, CTP in 190 (34%) patients, and MRI in 80 (14%) patients. NCT patients had significantly lower median times to groin puncture (61 min, IQR (40-117)) compared with CTP (114 min, IQR (81-152)) or MRI (124 min, IQR (87-165)). There were no differences in clinical outcomes, hemorrhage rates, or final infarct volumes among the groups.


CONCLUSIONS
The current retrospective study shows that multimodal imaging may be associated with delays in treatment without reducing hemorrhage rates or improving clinical outcomes. This exploratory analysis suggests that prospective randomised studies are warranted to support the hypothesis that advanced modality imaging is superior to NCT in improving clinical outcomes.
Department of Neurology, University of Maryland School of Medicine, Baltimore, Maryland, USA.
Kevin N
KN
Sheth
John B
JB
Terry
Raul G
RG
Nogueira
Anat
A
Horev
Thanh N
TN
Nguyen
Albert K
AK
Fong
Dheeraj
D
Gandhi
Shyam
S
Prabhakaran
Dolora
D
Wisco
Brenda A
BA
Glenn
Ashis H
AH
Tayal
Bryan
B
Ludwig
Muhammad Shazam
MS
Hussain
Tudor G
TG
Jovin
Paul F
PF
Clemmons
Carolyn
C
Cronin
David S
DS
Liebeskind
Melissa
M
Tian
Rishi
R
Gupta
D000368:Aged; D000369:Aged, 80 and over; D002545:Brain Ischemia / Q000175:diagnosis* / Q000601:surgery*; D015331:Cohort Studies; D003287:Contrast Media; D057510:Endovascular Procedures / Q000379:methods* / Q000592:standards; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods / Q000592:standards; D008297:Male; D008875:Middle Aged; D059906:Neuroimaging / Q000379:methods / Q000592:standards; D015424:Reperfusion / Q000379:methods* / Q000592:standards; D012189:Retrospective Studies; D020521:Stroke / Q000175:diagnosis* / Q000601:surgery*; D014057:Tomography, X-Ray Computed / Q000379:methods / Q000592:standards; D016896:Treatment Outcome
D003287:Contrast Media