Effect of fatty acid-binding protein 2 Ala54Thr genotype on weight loss and cardiovascular risk factors after a high-polyunsaturated fat diet in obese patients.
BACKGROUND
It has been found that the expression of fatty acid-binding protein 2 messenger RNA is under dietary control. The aim of our study was to investigate the influence of Thr54 polymorphism in the FABP2 gene on weight loss and secondarily in cardiovascular risk factors and serum adipokine after an enriched polyunsaturated fat hypocaloric diet in obese patients.


METHODS
A sample of 111 obese patients was analyzed. The enriched polyunsaturated fat hypocaloric diet during 3 months' intervention consisted of 1459 kcal, 45.7% carbohydrates, 34.4% lipids, and 19.9% proteins. The distribution of fats was as follows: 21.8% saturated fats, 55.5% monounsaturated fats, and 22.7% polyunsaturated fats. Level of significance was P < 0.05.


RESULTS
In Ala54Ala genotype, body mass index (-1.6 ± 1.5 kg/m(2)), weight (-3.2 ± 3.3 kg), fat mass (-3.1 ± 3.5 kg), and waist circumference (-3.3 ± 2.1 cm) decreased. In carriers of the Thr54 allele, body mass index (-1.9 ± 1.6 kg/m(2)), weight (- 4.7 ± 1.4 kg), and waist circumference (-3.9 ± 3.7 cm) decreased. These changes were significantly higher in the carriers of the Thr54 allele than noncarriers. Only in the carriers of Thr54 allele, total cholesterol levels (-11.4 ± 20.6 mg/dl), low-density lipoprotein cholesterol levels (-5.4 ± 10.6 mg/dL), insulin (-2.6 ± 3.4 MUI/L), and the level of homeostasis model assessment for insulin sensitivity (-0.9 ± 1.7 U) decreased.


CONCLUSIONS
Carriers of Thr54 allele have a better metabolic response than obese carriers with Ala54Ala genotype, with a decrease of total cholesterol, low-density lipoprotein cholesterol, insulin levels, leptin levels, and homeostasis model assessment for insulin sensitivity.
Center of Investigation of Endocrinology and Nutrition, Medicine School, University of Valladolid, Valladolid, Spain. dadluis@yahoo.es
Daniel
D
de Luis
Rocio
R
Aller
Olatz
O
Izaola
Manuel Gonzalez
MG
Sagrado
Beatriz
B
de la Fuente
Rosa
R
Conde
David
D
Primo
D000328:Adult; D000409:Alanine / Q000235:genetics; D031204:Caloric Restriction / Q000379:methods; D002318:Cardiovascular Diseases / Q000235:genetics / Q000517:prevention & control*; D004042:Dietary Fats, Unsaturated / Q000008:administration & dosage*; D050556:Fatty Acid-Binding Proteins / Q000235:genetics*; D005231:Fatty Acids, Unsaturated / Q000008:administration & dosage*; D005260:Female; D005500:Follow-Up Studies; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000178:diet therapy / Q000235:genetics*; D012307:Risk Factors; D013912:Threonine / Q000235:genetics; D015431:Weight Loss / Q000235:genetics*
D004042:Dietary Fats, Unsaturated; C493404:FABP2 protein, human; D050556:Fatty Acid-Binding Proteins; D005231:Fatty Acids, Unsaturated; D013912:Threonine; D000409:Alanine