[Effect of fullerene C60 on free-radical induced lipid peroxidation processes in bronchial asthma].
Lipids peroxidative oxidation as well as antioxidative enzymes superoxidedismutase and catalase activity state at the mice sensibilization with ovalbumine, its correction with fulleren FC60 as well as by its forms (FC60-OVA, mFC60 mFC60-OVA) modified and conjugated with ovalbumines have been studied. It has been demonstrated that the mice sensibilization with ovalbumin leads to the tissues peroxidative lipid oxidation processes enforcement as well as lowering antioxidative enzymes activity in lungs and spleen. Used different rulleren forms expressed antioxidative effect and modifying effect to antioxidative protection enzymes at a given pathology. The influence of fulleren FC 60 and its modified form (1,2-methanofulleren-C60)61-carbolacid was the mostly effective. The data recieved testify to the prospects of the fullerens further investigation as the potential medicines.
N A
NA
Bobrova
M V
MV
Mikitiuk
L A
LA
Kutsenko
I P
IP
Kaĭdashev
D000818:Animals; D000975:Antioxidants / Q000008:administration & dosage / Q000737:chemistry / Q000627:therapeutic use*; D001249:Asthma / Q000188:drug therapy* / Q000201:enzymology / Q000378:metabolism; D002374:Catalase / Q000378:metabolism; D004195:Disease Models, Animal; D005609:Free Radicals / Q000378:metabolism*; D037741:Fullerenes / Q000008:administration & dosage / Q000737:chemistry / Q000627:therapeutic use*; D015227:Lipid Peroxidation / Q000187:drug effects*; D008168:Lung / Q000187:drug effects / Q000201:enzymology / Q000378:metabolism; D051379:Mice; D008807:Mice, Inbred BALB C; D010047:Ovalbumin / Q000276:immunology; D013154:Spleen / Q000187:drug effects / Q000201:enzymology / Q000378:metabolism; D013482:Superoxide Dismutase / Q000378:metabolism; D017392:Thiobarbituric Acid Reactive Substances / Q000378:metabolism; D016896:Treatment Outcome
D000975:Antioxidants; D005609:Free Radicals; D037741:Fullerenes; D017392:Thiobarbituric Acid Reactive Substances; D010047:Ovalbumin; D002374:Catalase; D013482:Superoxide Dismutase; C069837:fullerene C60