DNA methylation studies using twins: what are they telling us?
Recent studies have identified both heritable DNA methylation effects and differential methylation in disease-discordant identical twins. Larger sample sizes, replication, genetic-epigenetic analyses and longitudinal assays are now needed to establish the role of epigenetic variants in disease.
Jordana T
JT
Bell
Tim D
TD
Spector
D019175:DNA Methylation; D004194:Disease / Q000235:genetics*; D044127:Epigenesis, Genetic; D057890:Epigenomics / Q000379:methods*; D055106:Genome-Wide Association Study; D006801:Humans; D014430:Twins, Monozygotic / Q000235:genetics*