Relationship between long-term exposure to low-level arsenic in drinking water and the prevalence of abnormal blood pressure.
Arsenic increases the risk and incidence of cardiovascular disease. To explore the impact of long-term exposure to low-level arsenic in drinking water on blood pressure including pulse pressure (PP) and mean arterial blood pressure (MAP), a cross-sectional study was conducted in 2010 in which the blood pressure of 405 villagers was measured, who had been drinking water with an inorganic arsenic content <50 μg/L. A multivariate logistic regression model was used to estimate odds ratios and 95% confidence intervals. After adjusting for age, gender, Body Mass Index (BMI), alcohol consumption and smoking, the odds ratios showed a 1.45-fold (95%CI: 0.63-3.35) increase in the group with >30-50 years of arsenic exposure and a 2.95-fold (95%CI: 1.31-6.67) increase in the group with >50 years exposure. Furthermore, the odds ratio for prevalence of abnormal PP and MAP were 1.06 (95%CI: 0.24-4.66) and 0.87 (95%CI: 0.36-2.14) in the group with >30-50 years of exposure, and were 2.46 (95%CI: 0.87-6.97) and 3.75 (95%CI: 1.61-8.71) for the group with >50 years exposure, compared to the group with arsenic exposure ≤ 30 years respectively. Significant trends for Hypertension (p<0.0001), PP (p<0.0001) and MAP (p=0.0016) were found. The prevalence of hypertension and abnormal PP as well as MAP is marked among a low-level arsenic exposure population, and significantly increases with the duration of arsenic exposure.
Wenzhou Medical College, Wenzhou, 325035, Zhejiang, PR China.
Chuanwu
C
Zhang
Guangyun
G
Mao
Suxia
S
He
Zuopeng
Z
Yang
Wei
W
Yang
Xiaojing
X
Zhang
Wenting
W
Qiu
Na
N
Ta
Li
L
Cao
Hui
H
Yang
Xiaojuan
X
Guo
D000293:Adolescent; D000328:Adult; D000368:Aged; D000428:Alcohol Drinking; D001151:Arsenic / Q000032:analysis* / Q000633:toxicity; D001794:Blood Pressure; D015992:Body Mass Index; D003430:Cross-Sectional Studies; D060766:Drinking Water; D004781:Environmental Exposure; D005260:Female; D006801:Humans; D006973:Hypertension / Q000175:diagnosis / Q000453:epidemiology*; D008297:Male; D008875:Middle Aged; D008986:Mongolia / Q000453:epidemiology; D015999:Multivariate Analysis; D016017:Odds Ratio; D014874:Water Pollutants, Chemical / Q000633:toxicity*; D014881:Water Supply; D055815:Young Adult
D060766:Drinking Water; D014874:Water Pollutants, Chemical; D001151:Arsenic