Poststroke depression and risk of recurrent stroke at 1 year in a Chinese cohort study.
BACKGROUND
Studies show that poststroke depression (PSD) increases mortality risk at 1 year. However, whether PSD increases the risk of recurrent stroke at 1 year remains unclear. This study was to investigate whether PSD at 2 weeks following a stroke could increase risk of recurrent stroke at 1 year.


RESULTS
This was a multi-centered prospective cohort study. A total of 2306 patients with acute stroke were enrolled in our study. PSD was diagnosed according to the criteria set by the Diagnostic and Statistical Manual of Mental Disorders, fourth edition (DSM-IV). The outcomes of recurrent stroke were followed up via face-to-face or phone interview. A total of 1713 patients had complete follow-up data, with 481 (28.1%) cases of PSD and 158 (9.2%) cases of cumulative recurrent stroke at 1 year. Multivariate logistic regression analysis showed a 49% increase of OR of recurrent stroke at 1 year in patients with PSD, compared to patients without PSD following a stroke (OR=1.49, 95%CI: 1.03-2.15). There was no significant correlation between anti-depressant drugs and the risk of recurrent stroke at 1 year following a stroke (OR=1.96, 95%: CI 0.95-4.04).


CONCLUSIONS
Based on the DSM-IV diagnostic criteria, nearly 3 out of 10 hospitalized stroke patients in China were diagnosed with PSD at 2 weeks following a stroke. PSD is associated with a higher risk of recurrent stroke at 1 year. Our study did not find benefit of anti-depressant drugs in reducing such risk.
Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China. Yhw0202@hotmail.com
Huai Wu
HW
Yuan
Chun Xue
CX
Wang
Ning
N
Zhang
Ying
Y
Bai
Yu Zhi
YZ
Shi
Yong
Y
Zhou
Yi Long
YL
Wang
Tong
T
Zhang
Juan
J
Zhou
Xin
X
Yu
Xin Yu
XY
Sun
Zhao Rui
ZR
Liu
Xing Quan
XQ
Zhao
Yong Jun
YJ
Wang
D000928:Antidepressive Agents / Q000627:therapeutic use; D044466:Asian People; D002681:China / Q000453:epidemiology; D015331:Cohort Studies; D003863:Depression / Q000209:etiology*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D012008:Recurrence; D012044:Regression Analysis; D012307:Risk Factors; D020521:Stroke / Q000150:complications* / Q000188:drug therapy / Q000453:epidemiology
D000928:Antidepressive Agents