Synthesis of bioreducible polycations with controlled topologies.
Bioreducible polycations, which possess disulfide linkages in the backbone, have appeared as promising gene delivery carriers due to their high stability in extracellular physiological condition and bioreduction-triggered release of genetic materials, as well as reduced cytotoxicity because intracellular cytosol is a reducing environment containing high level of reducing molecules such as glutathione. Here, we describe the syntheses of bioreducible polycations, and the methods for control over their topology are also presented.
CAS Key Lab of Soft Matter Chemistry, Department of Polymer Science and Engineering, University of Science and Technology of China, Hefei, People's Republic of China. yzyou@ustc.edu.cn
Ye-Zi
YZ
You
Jun-Jie
JJ
Yan
Zhi-Qiang
ZQ
Yu
David
D
Oupicky
D060326:Chemistry Techniques, Synthetic; D004220:Disulfides / Q000737:chemistry; D004337:Drug Carriers / Q000138:chemical synthesis* / Q000737:chemistry / Q000378:metabolism*; D010084:Oxidation-Reduction; D011073:Polyamines / Q000138:chemical synthesis* / Q000737:chemistry / Q000378:metabolism*; D000071228:Polyelectrolytes; D011094:Polyethyleneimine / Q000138:chemical synthesis / Q000737:chemistry / Q000378:metabolism; D058105:Polymerization; D011109:Polymethacrylic Acids / Q000138:chemical synthesis / Q000737:chemistry / Q000378:metabolism
D004220:Disulfides; D004337:Drug Carriers; D011073:Polyamines; D000071228:Polyelectrolytes; D011094:Polyethyleneimine; D011109:Polymethacrylic Acids; C030613:polymethacrylic acid