You got to know when to hold (or unfold) 'em….
In this issue of Molecular Cell, Hoffmann et al. (2012) demonstrate that the ribosome-associated bacterial chaperone Trigger Factor assists in the maturation of ribosome-attached nascent chains by acting as both a holdase and an unfoldase.
Department of Biochemistry and Molecular Biology, University of Massachusetts, Amherst, Amherst, MA 01003, USA. dhebert@biochem.umass.edu
Daniel N
DN
Hebert
Kshama D
KD
Chandrasekhar
Lila M
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Gierasch