Understanding NIK regulation from its structure.
In this issue of Structure, de Leon-Boenig and colleagues bring to light several key characteristics of NF-κB inducing kinase (NIK), which is at the center of many pathological disorders, using an impressive body of structural and functional studies. Structures of NIK described here provide deep insights into the mechanism of NIK activity regulation and may facilitate the design of new generation inhibitors for therapeutic use.
Department of Chemistry & Biochemistry, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA.
Zhihua
Z
Tao
Gourisankar
G
Ghosh