[Effect of deep-sea fish oil on improving memory in mice].
OBJECTIVE
To investigate the effects of deep-sea fish oil on improving memory in mice.


METHODS
One hundred and twenty male Kunming mice were allocated randomly into four groups: the control group and low-, medium-and high-dose group, and each group was administrated daily with deep-sea fish oil of 0, 0.15, 0.30 and 0.60 g/kg BW respectively per day for 30 days. The effects of deep-sea fish oil on memory were investigated by step-down test, step-through test and water maze tests.


RESULTS
In the medium-dose group, the latency phase was prolonged in the step-down test, and the time reached to the final point in the water maze test was shorter (P < 0.05). The indicators of passive avoidance test were not different statistically between fish oil groups and control group (P > 0.05).


CONCLUSIONS
Deep-sea fish oil may play an important role in memory improvement in mice.
Tianjin Centers for Disease Control and Prevention, Tianjin 300011, China. zengqiang@cdctj.gov.cn
Qiang
Q
Zeng
Jingshu
J
Zhang
Zhonghui
Z
Liu
Yang
Y
Wang
Hongliang
H
Liu
D000818:Animals; D004305:Dose-Response Relationship, Drug; D005395:Fish Oils / Q000008:administration & dosage*; D008297:Male; D008568:Memory / Q000187:drug effects*; D051379:Mice
D005395:Fish Oils