Diabetes genetic predisposition score and cardiovascular complications among patients with type 2 diabetes.
OBJECTIVE
To examine the association between genetic predisposition to type 2 diabetes (T2D) and risk of cardiovascular disease (CVD) among patients with T2D.


METHODS
The current study included 1,012 men and 1,310 women with T2D from the Health Professionals Follow-up Study and Nurses' Health Study, including 677 patients with CVD and 1,645 non-CVD control subjects. A genetic predisposition score (GPS) was calculated on the basis of 36 established independent diabetes-predisposing variants.


RESULTS
Each additional diabetes-risk allele in the GPS was associated with a 3% increased risk of CVD (odds ratio [OR] 1.03 [95% CI 1.00-1.06]). The OR was 1.47 (1.11-1.95) for CVD risk by comparing extreme quartiles of the GPS (P for trend = 0.01). We also found that the GPS was positively associated with hemoglobin A(1c) levels (P = 0.009).


CONCLUSIONS
Genetic predisposition to T2D is associated with an increased risk of cardiovascular complications in patients with T2D.
Department of Nutrition, Harvard School of Public Health, Boston, MA, USA. nhlqi@channing.harvard.edu
Qibin
Q
Qi
James B
JB
Meigs
Kathryn M
KM
Rexrode
Frank B
FB
Hu
Lu
L
Qi
D000328:Adult; D002318:Cardiovascular Diseases / Q000209:etiology / Q000235:genetics*; D003924:Diabetes Mellitus, Type 2 / Q000150:complications / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D005838:Genotype; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide / Q000235:genetics; D011446:Prospective Studies