Supramolecular nanoparticles generated by the self-assembly of polyrotaxanes for antitumor drug delivery.
A new approach of fabricating supramolecular nanoparticles generated by self-assembly polyrotaxanes for antitumor drug delivery has been reported. Cinnamic-acid-modified poly(ethylene glycol) chains were threaded in α-cyclodextrins to form polyrotaxanes. The polyrotaxanes self-assembled supramolecular nanoparticles. The morphology of the nanoparticles was changed from nanovesicle to micelle after the antitumor drug, doxorubicin, was loaded. The release profile of the drug-loaded nanoparticles was investigated, and it was found that the sustaining release time could last for 32 hours. The drug-loaded nanoparticles were co-cultured with mouse 4T1 breast cancer cells with a drug concentration of 10 μg/mL; the cell survival rate was 3.3% after a 72-hour incubation. In an in vivo study of breast cancer in a mouse model, the drug-loaded nanoparticles were injected in the tail veins of mice with a dose of 5 mg/kg body weight. The tumor inhibition rate of drug-loaded nanoparticles was 53%, which was better than that of doxorubicin hydrochloride. The cardiac toxicity of doxorubicin was decreased greatly after the encapsulation into supramolecular polyrotaxane nanoparticles.
National Engineering Research Center for Biomaterials, Sichuan University, Chengdu, China.
Rong
R
Liu
Yusi
Y
Lai
Bin
B
He
Yuan
Y
Li
Gang
G
Wang
Shuang
S
Chang
Zhongwei
Z
Gu
D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000737:chemistry; D001943:Breast Neoplasms / Q000188:drug therapy* / Q000473:pathology; D045744:Cell Line, Tumor; D003460:Crystallization / Q000379:methods*; D004317:Doxorubicin / Q000008:administration & dosage* / Q000737:chemistry; D046911:Macromolecular Substances / Q000737:chemistry*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D041681:NIH 3T3 Cells; D053769:Nanocapsules / Q000008:administration & dosage* / Q000737:chemistry* / Q000648:ultrastructure; D043862:Rotaxanes / Q000737:chemistry*
D000970:Antineoplastic Agents; D046911:Macromolecular Substances; D053769:Nanocapsules; D043862:Rotaxanes; D004317:Doxorubicin