title: Ketorolac-associated renal morbidity: risk factors in cardiac surgical infants.
abstract: We aimed to identify the risk factors for acute kidney injury in infants who have received ketorolac after a cardiac surgical procedure by identifying patients with a > or = 50% increase in serum creatinine from baseline and matching them by age with three controls that had < 50% increase in serum creatinine. Significant differences in primary surgical procedure, baseline serum creatinine, and concomitant aspirin use were noted. We conclude that the concomitant use of aspirin with ketorolac is associated with increased renal morbidity in young post-cardiac surgical infants.
authors.affiliation: Department of Pharmacy, Texas Children's Hospital, Houston, Texas 7703, USA. bsmoffet@texaschildrens.org
authors.forename: Brady S
authors.initials: BS
authors.lastname: Moffett
authors.forename: Antonio
authors.initials: A
authors.lastname: Cabrera
mesh_terms: D058186:Acute Kidney Injury / Q000097:blood / Q000139:chemically induced*; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects*; D001241:Aspirin / Q000627:therapeutic use; D006348:Cardiac Surgical Procedures / Q000706:statistics & numerical data*; D016022:Case-Control Studies; D003404:Creatinine / Q000097:blood; D005260:Female; D018729:Fontan Procedure / Q000706:statistics & numerical data; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D020910:Ketorolac / Q000009:adverse effects*; D008297:Male; D010149:Postoperative Pain / Q000188:drug therapy*; D011183:Postoperative Complications / Q000097:blood / Q000139:chemically induced*; D012189:Retrospective Studies; D012307:Risk Factors
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D003404:Creatinine; D001241:Aspirin; D020910:Ketorolac