title: Evaluation and cost analysis of national health policy of thalassaemia screening in west-azerbaijan province of iran.
abstract: BACKGROUND
  Thalassaemia is one of the most common Mendelian disorders in Mediterranean area. Iran has about 26,000 Thalassaemic patients, so it is one of the most affected countries. The aim of this study was to evaluate the screening program and cost analysis of Thalassaemia prevention program in West-Azerbaijan province of Iran.
  
  
  METHODS
  This study evaluated the efficacy of Health system's Thalassaemia prevention program with a sensitivity analysis for its costs. The second five years of the program was evaluated. The economic burden of Thalassaemia is determined by the birth prevalence of the affected infants and the cost that is accrued to treat the infected individuals and was compared with the total cost of screening the couples for thalassemia trait.
  
  
  RESULTS
  The average incidence rate of major Thalassaemia was 19.8 per 100,000 live births and mean coverage rate of program was 74%. The rate of canceling the marriage among carrier couples was 53%. Cost analysis showed that the cost of screening and prenatal diagnosis program was much lower than the cost of treatment in potential thalassaemic patients.
  
  
  CONCLUSIONS
  The prevention program of Thalassaemia including a premarital and pre-natal screening in west Azerbaijan province is demonstrated to be cost-effective. Taking some actions in order to increase the coverage of pre-marital screening, providing pre-natal diagnosis in private and public sector, complete insurance coverage for the high-risk couples to perform the investigations more easily, were recommended.
authors.affiliation: Department of Epidemiology & Biostatistics, Tehran University of Medical Sciences, Iran.
authors.forename: Elham
authors.initials: E
authors.lastname: Ahmadnezhad
authors.forename: Nariman
authors.initials: N
authors.lastname: Sepehrvand
authors.forename: Farshid Fayyaz
authors.initials: FF
authors.lastname: Jahani
authors.forename: Sanaz
authors.initials: S
authors.lastname: Hatami
authors.forename: Catauon
authors.initials: C
authors.lastname: Kargar
authors.forename: Majid
authors.initials: M
authors.lastname: Mirmohammadkhani
authors.forename: Shahrzad
authors.initials: S
authors.lastname: Bazargan-Hejazi
keywords: Cost analysis; Iran; Thalassaemia; screening