title: Serum ferroxidase albumin ratio as a marken in pulmonary tuberculosis.
abstract: Serum ferroxidase and albumin levels were determined in 98 patients of tubercuiosis, of whom 49 were freshly diagnosed, sputum positive (group-I) & 49 were completely treated patients (group-II). Forty nine age and sex matched healthy individuals were taken as controls. Mean±SD of serum ferroxidase and albumin levels in controls, group-I and group-II was found to be 864.35±106.35 IU/L & 3.91±0.234 g/dL, 1603.76±222.65 IU/L & 3.24±0.518 g/dL and 1001.78±201.63 IU/L & 3.82±0.43 g/dL, respectively. Serum ferroxidase in group I was significantly higher as compared to controls and group-II (p<0.01). The decreased levels of serum albumin in group I, as compared to control and group-II was statistically significant (p<0.01). Serum ferroxidase: albumin ratio (Ferroxidase in International Unit per gram of albumin) in group I (50.47±10.36 IU/g) was significantly higher than controls (22.22±3.3 IU/g), (p<0.001) while in group II it was significantly lower (26.72±7.18 IU/g, p<0.001) than group-I and close to control values. Serum ferroxidase: albumin ratio (IU/g) can therefore be incorporated as a surrogate marker to assist in diagnosis and prognosis of pulmonary tuberculosis.
authors.affiliation: Dept of Biochemistry, Armed Forces Medical College, 411 040 Pune, (India).
authors.forename: Hitender Singh
authors.initials: HS
authors.lastname: Batra
authors.forename: Parduman
authors.initials: P
authors.lastname: Singh
authors.forename: Babu Lal
authors.initials: BL
authors.lastname: Somani
authors.forename: Ashish
authors.initials: A
authors.lastname: Gupta
authors.forename: Sangeetha
authors.initials: S
authors.lastname: Sampath
authors.forename: Vivek
authors.initials: V
authors.lastname: Ambade
keywords: Albumin; Diagnosis; Ferroxidase; Marker; Tuberculosis