title: [The value of compliance during chronic administration of acetylsalicylic acid in patients with acute coronary syndrome: results of the study FORPOST].
abstract: Found low compliance of admission to long-term acetylsalicylic acid (ASA) in patients with acute coronary syndrome (ACS): 74.9% of patients reported that the suspended or completely stopped taking the drug, and only 16.2% were fully committed to the long-term therapy with ASA. Patients are significantly more likely to discontinue conventional and buffered forms of ASA compared with intestinal-soluble forms of the drug (odds ratio - OR=1.81, 95% confidence interval - CI: 1.20 to 2.72; p=0,0027). The most common causes of low noncompliance were to receive ASA or the development of fear of adverse drug reactions (ADRs) - 47.1%, and the forgetfulness of the patients taking the drug regularly (25.4%). When receiving enteric forms of ASA NLR developed significantly less than in the case of buffered (OR 0.49, 95% CI, 0.35 to 0,69; p=0,00002) and "ordinary" (OR 0.21, 95 % CI 0.13 to 0,33; p=0,00001) forms of ASA. Compliance of the highest among all the drugs ASA, according to estimates by using a 10-point visual analog scale, were observed in enteric-coated forms of ASA (average score of 8.3+/-1.4). Some of the lowest noncompliance were noted to receive the "regular" aspirin tablet (6.9+/-1.4 points).
authors.forename: A N
authors.initials: AN
authors.lastname: Baglikov
authors.forename: V V
authors.initials: VV
authors.lastname: Rafal'skiĭ
mesh_terms: D015746:Abdominal Pain / Q000139:chemically induced; D054058:Acute Coronary Syndrome / Q000453:epidemiology / Q000517:prevention & control / Q000523:psychology; D000368:Aged; D001241:Aspirin / Q000008:administration & dosage / Q000009:adverse effects; D064420:Drug-Related Side Effects and Adverse Reactions / Q000517:prevention & control / Q000523:psychology; D005260:Female; D006470:Hemorrhage / Q000139:chemically induced; D006801:Humans; D008297:Male; D055118:Medication Adherence / Q000523:psychology; D008875:Middle Aged; D010975:Platelet Aggregation Inhibitors / Q000008:administration & dosage / Q000009:adverse effects; D012426:Russia / Q000453:epidemiology; D011795:Surveys and Questionnaires; D013608:Tablets, Enteric-Coated; D016903:Drug Monitoring
chemical_list: D010975:Platelet Aggregation Inhibitors; D013608:Tablets, Enteric-Coated; D001241:Aspirin