title: Controllable in vivo hyperthermia effect induced by pulsed high intensity focused ultrasound with low duty cycles.
abstract: High intensity focused ultrasound (HIFU)-induced hyperthermia is a promising tool for cancer therapy. Three-dimensional nonlinear acoustic-bioheat transfer-blood flow-coupling model simulations and in vivo thermocouple measurements were performed to study hyperthermia effects in rabbit auricular vein exposed to pulsed HIFU (pHIFU) at varied duty cycles (DCs). pHIFU-induced temperature elevations are shown to increase with increasing DC. A critical DC of 6.9% is estimated for temperature at distal vessel wall exceeding 44 °C, although different tissue depths and inclusions could affect the DC threshold. The results demonstrate clinic potentials of achieving controllable hyperthermia by adjusting pHIFU DCs, while minimizing perivascular thermal injury.
authors.affiliation: Key Laboratory of Modern Acoustics (Nanjing University), Ministry of Education, Nanjing, Jiangsu 210093, China.
authors.forename: Juan
authors.initials: J
authors.lastname: Tu
authors.forename: Joo
authors.initials: J
authors.lastname: Ha Hwang
authors.forename: Tao
authors.initials: T
authors.lastname: Chen
authors.forename: Tingbo
authors.initials: T
authors.lastname: Fan
authors.forename: Xiasheng
authors.initials: X
authors.lastname: Guo
authors.forename: Lawrence A
authors.initials: LA
authors.lastname: Crum
authors.forename: Dong
authors.initials: D
authors.lastname: Zhang