title: PPARs: history and advances.
abstract: Peroxisome proliferator-activated receptors (PPARs) are members of the steroid hormone receptor superfamily, discovered in 1990. To date, three PPAR subtypes have been identified; PPARα, PPAR β/δ, and PPARγ. These receptors share a high degree of homology but differ in tissue distribution and ligand specificity. PPARs have been implicated in the etiology as well as treatment of several important diseases and pathological conditions such as diabetes, inflammation, senescence-related diseases, regulation of fertility, and various types of cancer. Consequently, significant efforts to discover novel PPAR roles and delineate molecular mechanisms involved in their activation and repression as well as develop safer and more effective PPAR modulators, as therapeutic agents to treat a myriad of diseases and conditions, are underway. This volume of Methods in Molecular Biology contains details of experimental protocols used in researching these receptors.
authors.affiliation: University of Missouri-Kansas City, Kansas City, MO, USA.
authors.forename: Jihan
authors.initials: J
authors.lastname: Youssef
authors.forename: Mostafa Z
authors.initials: MZ
authors.lastname: Badr
mesh_terms: D000818:Animals; D049673:History, 20th Century; D049674:History, 21st Century; D006801:Humans; D047492:Peroxisome Proliferator-Activated Receptors / Q000737:chemistry / Q000266:history / Q000378:metabolism; D012106:Research
chemical_list: D047492:Peroxisome Proliferator-Activated Receptors