title: Bovine papillomavirus type 2 infects the urinary bladder of water buffalo (Bubalus bubalis) and plays a crucial role in bubaline urothelial carcinogenesis.
abstract: Bovine papillomavirus type 2 (BPV-2) has been shown to infect and play a role in urinary bladder carcinogenesis of buffaloes grazed on pastures with ferns from the Marmara and Black Sea Regions of Turkey. BPV-2 DNA has been found in both neoplastic and non-neoplastic lesions of the urinary bladder. Furthermore, this virus may be a normal inhabitant of the urinary bladder since BPV-2 DNA has also been detected in clinically normal buffaloes. The viral activation by fern immunosuppressant or carcinogen may trigger the urothelial cell transformation. The E5 oncoprotein was solely detected in urothelial tumours and appeared to be co-localized with the overexpressed and phosphorylated platelet derived growth factor (PDGF) β receptor in a double-colour immunofluorescence assay. Our results indicate that the E5-PDGF β receptor interaction also occurs in spontaneous tumours of the bubaline urinary bladder, revealing an additional role of BPV-2 in bladder carcinogenesis of buffaloes.
authors.affiliation: Dipartimento di Patologia e Sanità Animale, Sezione Malattie Infettive, Facoltà di Medicina Veterinaria, Università di Napoli Federico II, Napoli, Italy.
authors.forename: Sante
authors.initials: S
authors.lastname: Roperto
authors.affiliation: Dipartimento di Patologia e Sanità Animale, Sezione Patologia Generale, Facoltà di Medicina Veterinaria, Università di Napoli Federico II, Napoli, Italy.
authors.forename: Valeria
authors.initials: V
authors.lastname: Russo
authors.affiliation: Department of Pathology, Faculty of Veterinary Medicine, Ankara University, Ankara, Turkey.
authors.forename: Ayhan
authors.initials: A
authors.lastname: Ozkul
authors.affiliation: Health Research and Practice Center, Faculty of Medicine, Gazi University, Ankara, Turkey.
authors.forename: Aylin
authors.initials: A
authors.lastname: Sepici-Dincel
authors.affiliation: Dipartimento di Patologia e Sanità Animale, Sezione Patologia Generale, Facoltà di Medicina Veterinaria, Università di Napoli Federico II, Napoli, Italy.
authors.forename: Paola
authors.initials: P
authors.lastname: Maiolino
authors.affiliation: Dipartimento di Patologia e Sanità Animale, Sezione Patologia Generale, Facoltà di Medicina Veterinaria, Università di Napoli Federico II, Napoli, Italy.
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Borzacchiello
authors.affiliation: Department of Pathophysiology, Faculty of Veterinary Medicine, University of Agricultural Sciences and Veterinary Medicine, Cluj-Napoca, Romania.
authors.forename: Ioan
authors.initials: I
authors.lastname: Marcus
authors.affiliation: Dipartimento di Patologia e Sanità Animale, Sezione Patologia Generale, Facoltà di Medicina Veterinaria, Università di Napoli Federico II, Napoli, Italy.
authors.forename: Iolanda
authors.initials: I
authors.lastname: Esposito
authors.affiliation: Dipartimento di Patologia e Sanità Animale, Sezione Patologia Generale, Facoltà di Medicina Veterinaria, Università di Napoli Federico II, Napoli, Italy.
authors.forename: Marita Georgia
authors.initials: MG
authors.lastname: Riccardi
authors.affiliation: Dipartimento di Patologia e Sanità Animale, Sezione Patologia Generale, Facoltà di Medicina Veterinaria, Università di Napoli Federico II, Napoli, Italy.
authors.forename: Franco
authors.initials: F
authors.lastname: Roperto
mesh_terms: D000818:Animals; D052688:Bovine papillomavirus 1 / Q000472:pathogenicity*; D002020:Buffaloes; D029624:Ferns / Q000633:toxicity; D009856:Oncogene Proteins, Viral / Q000378:metabolism; D030361:Papillomavirus Infections / Q000150:complications / Q000662:veterinary* / Q000821:virology; D010766:Phosphorylation; D011499:Protein Processing, Post-Translational; D020797:Receptor, Platelet-Derived Growth Factor beta / Q000378:metabolism; D014421:Turkey; D001743:Urinary Bladder / Q000473:pathology* / Q000821:virology*; D001749:Urinary Bladder Neoplasms / Q000662:veterinary* / Q000821:virology; D019459:Urothelium / Q000473:pathology* / Q000821:virology*
chemical_list: D009856:Oncogene Proteins, Viral; D020797:Receptor, Platelet-Derived Growth Factor beta