title: hs-CRP and oxidative stress in young CAD patients: A pilot study.
abstract: Premature coronary artery disease (CAD) is common in India. We, therefore, studied oxidative stress, dyslipidemia, and high sensitivity-C reactive protein (hs-CRP) levels in young CAD patients. Present study consisted of male CAD patients below 40 years and age and sex matched healthy controls (n=30 each). Fasting blood samples were analyzed for serum lipid profile, malondialdehyde, antioxidant enzymes and hs-CRP levels. Dyslipidemia was observed in 90% of the young CAD patients, of which 72.2% showed increased serum triglycerides and decreased HDL-cholesterol. LDL-cholesterol levels were high in 77.8%. Serum malondialdehyde and hs-CRP levels were increased significantly (p<0.0001) as compared to controls. hs-CRP levels were in high risk range in all the young patients. However, glutathione peroxidase activity was reduced significantly (p<0.05). Our data suggests that elevated hs-CRP levels along with dyslipidemia and oxidative stress adds to the predictive value of premature CAD in young Indians.
authors.affiliation: Department of Biochemistry, University College of Medical Sciences & GTB Hospital, Delhi, India.
authors.forename: Suman B
authors.initials: SB
authors.lastname: Sharma
authors.forename: Seema
authors.initials: S
authors.lastname: Garg
authors.forename: Abhinav
authors.initials: A
authors.lastname: Veerwal
authors.forename: Sridhar
authors.initials: S
authors.lastname: Dwivedi
keywords: Dyslipidemia; Malondialdehyde; Premature CAD; high sensitivity-C reactive protein