title: Formation and inhibition of Nε-(carboxymethyl)lysine in saccharide-lysine model systems during microwave heating.
abstract: N(ε)-(carboxymethyl) lysine (CML) is the most abundant advanced glycation end product (AGE), and frequently selected as an AGEs marker in laboratory studies. In this paper, the formation and inhibition of N(ε)-(carboxymethyl)lysine in saccharide-lysine model systems during microwave heating have been studied. The microwave heating treatment significantly promoted the formation of CML during Maillard reactions, which was related to the reaction temperature, time and type of saccharide. The order of CML formation for different saccharides was lactose > glucose > sucrose. Then, the inhibition effect on CML by five inhibitors was further examined. According to the results, ascorbic acid and tocopherol did not affect inhibition of CML, in contrast, thiamin, rutin and quercetin inhibited CML formation, and the inhibitory effects were concentration dependent.
authors.affiliation: College of Light Industry and Food Sciences, South China University of Technology, Guangzhou 510640, China. lcbingli@scut.edu.cn
authors.forename: Lin
authors.initials: L
authors.lastname: Li
authors.forename: Lipeng
authors.initials: L
authors.lastname: Han
authors.forename: Quanyi
authors.initials: Q
authors.lastname: Fu
authors.forename: Yuting
authors.initials: Y
authors.lastname: Li
authors.forename: Zhili
authors.initials: Z
authors.lastname: Liang
authors.forename: Jianyu
authors.initials: J
authors.lastname: Su
authors.forename: Bing
authors.initials: B
authors.lastname: Li
mesh_terms: D000975:Antioxidants / Q000737:chemistry; D001205:Ascorbic Acid / Q000737:chemistry; D005947:Glucose / Q000031:analogs & derivatives* / Q000737:chemistry*; D017127:Glycation End Products, Advanced / Q000138:chemical synthesis* / Q000737:chemistry; D008239:Lysine / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry; D008872:Microwaves; D011794:Quercetin / Q000737:chemistry; D012431:Rutin / Q000737:chemistry; D013831:Thiamine / Q000737:chemistry; D024505:Tocopherols / Q000737:chemistry
chemical_list: D000975:Antioxidants; D017127:Glycation End Products, Advanced; D012431:Rutin; C048496:N(6)-carboxymethyllysine; D011794:Quercetin; D005947:Glucose; D008239:Lysine; D001205:Ascorbic Acid; D024505:Tocopherols; D013831:Thiamine