title: Effectiveness of a Protective Environment implementation for cancer patients with chemotherapy-induced neutropenia on fever and mortality incidence.
abstract: In a quasiexperimental study conducted to evaluate the impact of a Protective Environment implementation, febrile neutropenia (P = .009), overall mortality (P = .001), and 30-day adjusted mortality (P = .02) were reduced in cancer patients with chemotherapy-induced neutropenia. Our study highlights the potential success of a set of prevention measures mainly designed to reduce invasive environmental fungal infections in allogeneic hematopoietic stem cell transplant patients, in reducing fever and mortality among neutropenic cancer patients.
authors.affiliation: Post-Graduate Program in Medical Sciences, School of Medicine, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil. paulastoll@hotmail.com
authors.forename: Paula
authors.initials: P
authors.lastname: Stoll
authors.forename: Lúcia Mariano da Rocha
authors.initials: LM
authors.lastname: Silla
authors.forename: Caroline Mioto Menegat
authors.initials: CM
authors.lastname: Cola
authors.forename: Bruno Ismail
authors.initials: BI
authors.lastname: Splitt
authors.forename: Leila Beltrami
authors.initials: LB
authors.lastname: Moreira
mesh_terms: D000328:Adult; D000368:Aged; D016902:Air Pollution, Indoor; D004358:Drug Therapy / Q000379:methods*; D064420:Drug-Related Side Effects and Adverse Reactions; D005260:Female; D005335:Fever of Unknown Origin / Q000401:mortality* / Q000517:prevention & control*; D019337:Hematologic Neoplasms / Q000188:drug therapy*; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D009503:Neutropenia / Q000139:chemically induced*; D016019:Survival Analysis