title: Insulin signaling and insulin resistance.
abstract: Insulin resistance or its sequelae may be the common etiology of maladies associated with metabolic syndrome (eg, hypertension, type 2 diabetes, atherosclerosis, heart attack, stroke, and kidney failure). It is thus important to understand those factors that affect insulin sensitivity. This review stems from the surprising discovery that interference with angiotensin signaling improves insulin sensitivity, and it provides a general overview of insulin action and factors that control insulin sensitivity.
authors.affiliation: Department of Medical Education, Paul L. Foster School of Medicine, Texas Tech University Health Sciences Center, El Paso, TX 79905, USA. elmus.beale@ttuhsc.edu
authors.forename: Elmus G
authors.initials: EG
authors.lastname: Beale
mesh_terms: D000818:Animals; D003226:Congresses as Topic; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000628:therapy; D006801:Humans; D006973:Hypertension / Q000097:blood / Q000628:therapy; D007328:Insulin / Q000097:blood*; D007333:Insulin Resistance / Q000502:physiology*; D024821:Metabolic Syndrome / Q000097:blood / Q000628:therapy; D015398:Signal Transduction / Q000502:physiology*
chemical_list: D007328:Insulin