title: Formation of SERS active nanoparticle assemblies via specific carbohydrate-protein interactions.
abstract: An on/off SERS aggregation system has been designed to investigate carbohydrate-lectin interactions. Detection of the lectin ConA was achieved at pico molar levels. Discrimination was also demonstrated between two different carbohydrate moieties demonstrating the specific interaction between the carbohydrate and specific protein present.
authors.affiliation: Centre for Molecular Nanometrology, WestCHEM, Pure and Applied Chemistry, University of Strathclyde, 295 Cathedral Street, Glasgow, G1 1XL, UK.
authors.forename: Derek
authors.initials: D
authors.lastname: Craig
authors.forename: Jonathan
authors.initials: J
authors.lastname: Simpson
authors.forename: Karen
authors.initials: K
authors.lastname: Faulds
authors.forename: Duncan
authors.initials: D
authors.lastname: Graham
mesh_terms: D002241:Carbohydrates / Q000737:chemistry; D003208:Concanavalin A / Q000737:chemistry* / Q000378:metabolism; D005690:Galactose / Q000737:chemistry; D007785:Lactose / Q000737:chemistry; D037102:Lectins / Q000737:chemistry* / Q000378:metabolism; D053758:Nanoparticles / Q000737:chemistry*; D013059:Spectrum Analysis, Raman
chemical_list: D002241:Carbohydrates; D037102:Lectins; D003208:Concanavalin A; D007785:Lactose; D005690:Galactose