title: Decline in macrolide-resistant Streptococcus pyogenes isolates from French children.
abstract: We studied the macrolide resistance and serotypes of 585 group A streptococcus (GAS) isolates collected from French children with pharyngitis. Nineteen isolates (3.2%) were erythromycin-resistant and harbored the following resistance genes: 31.6% mef(A), 15.8% erm(A), and 52.6% erm(B). The 19 isolates included 7 different emm types (4, 1, 11, 2, 28, 12, and 77) and 7 corresponding multilocus sequence types. The current fall in macrolide consumption has led to a very low rate of GAS macrolide resistance.
authors.affiliation: Laboratoire d'Etudes de Génétique Bactérienne dans les infections de l'enfant (EA3105), Université Denis Diderot-Paris 7, Service de Microbiologie, Hôpital Robert Debré, 75019 Paris, France.
authors.forename: Camille
authors.initials: C
authors.lastname: d'Humières
authors.forename: Robert
authors.initials: R
authors.lastname: Cohen
authors.forename: Corinne
authors.initials: C
authors.lastname: Levy
authors.forename: Philippe
authors.initials: P
authors.lastname: Bidet
authors.forename: Franck
authors.initials: F
authors.lastname: Thollot
authors.forename: Alain
authors.initials: A
authors.lastname: Wollner
authors.forename: Edouard
authors.initials: E
authors.lastname: Bingen
mesh_terms: D000293:Adolescent; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D002648:Child; D002675:Child, Preschool; D016000:Cluster Analysis; D024881:Drug Resistance, Bacterial; D005602:France / Q000453:epidemiology; D005798:Genes, Bacterial; D005838:Genotype; D006801:Humans; D018942:Macrolides / Q000494:pharmacology*; D058885:Multilocus Sequence Typing; D010612:Pharyngitis / Q000453:epidemiology* / Q000382:microbiology; D015995:Prevalence; D012703:Serotyping; D013290:Streptococcal Infections / Q000453:epidemiology* / Q000382:microbiology; D013297:Streptococcus pyogenes / Q000145:classification / Q000187:drug effects* / Q000302:isolation & purification; D037521:Virulence Factors / Q000235:genetics
chemical_list: D000900:Anti-Bacterial Agents; D018942:Macrolides; D037521:Virulence Factors