title: Epidemic myalgia in adults associated with human parechovirus type 3 infection, Yamagata, Japan, 2008.
abstract: Human parechovirus has rarely been shown to cause clinical disease in adults. During June-August 2008, a total of 22 adults sought treatment at Yonezawa City Hospital in Yamagata, Japan, for muscle pain and weakness of all limbs; most also had fever and sore throat. All patients received a clinical diagnosis of epidemic myalgia; clinical laboratory findings suggested an acute inflammatory process. Laboratory confirmation of infection with human parechovirus type 3 (HPeV3) was made for 14 patients; we isolated HPeV3 from 7 patients, detected HPeV3 genome in 11, and observed serologic confirmation of infection in 11. Although HPeV3 is typically associated with disease in young children, our results suggest that this outbreak of myalgia among adults was associated with HPeV3 infection. Clinical consideration should be given to HPeV3 not only in young children but also in adults when an outbreak occurs in the community.
authors.affiliation: Tokyo University of Agriculture and Technology Research and Education Center for Prevention of Global Infectious Diseases of Animals, Tokyo, Japan.mizutak@pref.yamagata.jp
authors.forename: Katsumi
authors.initials: K
authors.lastname: Mizuta
authors.forename: Makoto
authors.initials: M
authors.lastname: Kuroda
authors.forename: Masayuki
authors.initials: M
authors.lastname: Kurimura
authors.forename: Yoshikazu
authors.initials: Y
authors.lastname: Yahata
authors.forename: Tsuyoshi
authors.initials: T
authors.lastname: Sekizuka
authors.forename: Yoko
authors.initials: Y
authors.lastname: Aoki
authors.forename: Tatsuya
authors.initials: T
authors.lastname: Ikeda
authors.forename: Chieko
authors.initials: C
authors.lastname: Abiko
authors.forename: Masahiro
authors.initials: M
authors.lastname: Noda
authors.forename: Hirokazu
authors.initials: H
authors.lastname: Kimura
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Mizutani
authors.forename: Takeo
authors.initials: T
authors.lastname: Kato
authors.forename: Toru
authors.initials: T
authors.lastname: Kawanami
authors.forename: Tadayuki
authors.initials: T
authors.lastname: Ahiko
mesh_terms: D000328:Adult; D000368:Aged; D004196:Disease Outbreaks; D005260:Female; D016679:Genome, Viral; D006801:Humans; D007564:Japan / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D008969:Molecular Sequence Data; D030061:Parechovirus / Q000145:classification / Q000235:genetics / Q000302:isolation & purification*; D010802:Phylogeny; D010850:Picornaviridae Infections / Q000175:diagnosis / Q000453:epidemiology*; D011000:Pleurodynia, Epidemic / Q000175:diagnosis / Q000453:epidemiology* / Q000209:etiology*; D012367:RNA, Viral; D012703:Serotyping
chemical_list: D012367:RNA, Viral