title: Comparison of the larynx-associated lymphoid tissue in the false vocal cords and subglottis in pediatric autopsies.
abstract: The aim this work was to compare the distribution of cellular phenotypes of the LF in the FVC to the ones in the subglottic region in pediatric autopsy, relating this distribution to age and different causes of death. We analyzed 60 larynges of newborns and children autopsied in the period from 1993 to 2003. The fragments were prepared in order to perform histochemical and immunohistochemical techniques. The morphological analysis showed cases that presented LF only in FVC (35%), LF only in the subglottic region (20%), lack of LF in FVC (30%) and lymphoid aggregates, which did not characterize an LF (15%). The cases of LF in the subglottic region were significantly younger compared to the ones that presented LF in the FVC (p=0.017). The LF in the subglottic region was bigger than the LF in the FVC (p=0.020). There was no significant difference between the cause of death and cellular phenotype for both FVC and the subglottic region. In conclusion, the cells that make up the LF in the FVC in newborns and children younger than one year have functional characteristics similar to LF cells in the subglottic region, suggesting that there are similarities with LALT.
authors.affiliation: General Pathology Division of the Oeste Paulista University, Presidente Prudente, SP, Brazil. renatacalciolari@terra.com.br
authors.forename: Renata Calciolari
authors.initials: RC
authors.lastname: Rossi e Silva
authors.forename: Janainna Grazielle Pacheco
authors.initials: JG
authors.lastname: Olegário
authors.forename: Débora Tavares de Rezende e Silva
authors.initials: DT
authors.lastname: Abate
authors.forename: Ana Karina Marques
authors.initials: AK
authors.lastname: Salge
authors.forename: Luiz César
authors.initials: LC
authors.lastname: Peres
authors.forename: Rosana Rosa Miranda
authors.initials: RR
authors.lastname: Corrêa
authors.forename: Eumenia Costa da Cunha
authors.initials: EC
authors.lastname: Castro
authors.forename: Vicente de Paula Antunes
authors.initials: Vde P
authors.lastname: Teixeira
mesh_terms: D000367:Age Factors; D015703:Antigens, CD / Q000378:metabolism; D001344:Autopsy; D015415:Biomarkers / Q000378:metabolism; D002423:Cause of Death; D020566:Dendritic Cells, Follicular / Q000166:cytology / Q000378:metabolism; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008221:Lymphoid Tissue / Q000033:anatomy & histology* / Q000378:metabolism; D008264:Macrophages / Q000166:cytology / Q000378:metabolism; D008297:Male; D012141:Respiratory Tract Infections / Q000276:immunology / Q000401:mortality / Q000473:pathology; D013601:T-Lymphocytes / Q000166:cytology / Q000378:metabolism; D014827:Vocal Cords / Q000033:anatomy & histology* / Q000378:metabolism
chemical_list: D015703:Antigens, CD; D015415:Biomarkers