title: Fosfomycin-daptomycin and other fosfomycin combinations as alternative therapies in experimental foreign-body infection by methicillin-resistant Staphylococcus aureus.
abstract: The efficacy of daptomycin, imipenem, or rifampin with fosfomycin was evaluated and compared with that of daptomycin-rifampin in a tissue cage model infection caused by methicillin-resistant Staphylococcus aureus (MRSA). Strain HUSA 304 was used. The study yielded the following results for MICs (in μg/ml): fosfomycin, 4; daptomycin, 1; imipenem, 0.25; and rifampin, 0.03. The study yielded the following results for minimum bactericidal concentration (MBC) (in μg/ml): fosfomycin, 8; daptomycin, 4; imipenem, 32; and rifampin, 0.5. Daptomycin-rifampin was confirmed as the most effective therapy against MRSA foreign-body infections. Fosfomycin combinations with high doses of daptomycin and rifampin were efficacious alternative therapies in this setting. Fosfomycin-imipenem was relatively ineffective and did not protect against resistance.
authors.affiliation: Laboratory of Experimental Infection, Infectious Diseases Service, IDIBELL, Hospital Universitari de Bellvitge, Barcelona, Spain. cgarrigos@idibell.cat
authors.forename: C
authors.initials: C
authors.lastname: Garrigós
authors.forename: O
authors.initials: O
authors.lastname: Murillo
authors.forename: J
authors.initials: J
authors.lastname: Lora-Tamayo
authors.forename: R
authors.initials: R
authors.lastname: Verdaguer
authors.forename: F
authors.initials: F
authors.lastname: Tubau
authors.forename: C
authors.initials: C
authors.lastname: Cabellos
authors.forename: J
authors.initials: J
authors.lastname: Cabo
authors.forename: J
authors.initials: J
authors.lastname: Ariza
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000097:blood / Q000493:pharmacokinetics / Q000494:pharmacology*; D015169:Colony Count, Microbial; D017576:Daptomycin / Q000097:blood / Q000493:pharmacokinetics / Q000494:pharmacology*; D004195:Disease Models, Animal; D004338:Drug Combinations; D024881:Drug Resistance, Bacterial; D005549:Foreign-Body Reaction / Q000097:blood / Q000188:drug therapy* / Q000382:microbiology; D005578:Fosfomycin / Q000097:blood / Q000493:pharmacokinetics / Q000494:pharmacology*; D015378:Imipenem / Q000097:blood / Q000493:pharmacokinetics / Q000494:pharmacology*; D055624:Methicillin-Resistant Staphylococcus aureus / Q000187:drug effects* / Q000254:growth & development; D008826:Microbial Sensitivity Tests; D051381:Rats; D017208:Rats, Wistar; D012293:Rifampin / Q000097:blood / Q000493:pharmacokinetics / Q000494:pharmacology*; D013203:Staphylococcal Infections / Q000097:blood / Q000188:drug therapy* / Q000382:microbiology
chemical_list: D000900:Anti-Bacterial Agents; D004338:Drug Combinations; D005578:Fosfomycin; D015378:Imipenem; D017576:Daptomycin; D012293:Rifampin