title: The potential benefit of stem cell therapy after stroke: an update.
abstract: Stroke is a leading cause of death and disability worldwide. Stem cell therapy is an emerging therapeutic modality with evidence of significant benefits in preclinical stroke models. A number of phase I and II clinical trials have now been completed, with several more currently under way. Translation to the bedside, however, remains a long way off, and there are many questions that remain unanswered. This review will summarize the current evidence and ongoing clinical trials worldwide, and explore the challenges to making this a realistic treatment option for the future.
authors.affiliation: Department of Stroke Medicine, Imperial College Healthcare NHS Trust, London, UK. sbanerjee73@hotmail.com
authors.forename: Soma
authors.initials: S
authors.lastname: Banerjee
authors.forename: Deborah A
authors.initials: DA
authors.lastname: Williamson
authors.forename: Nagy
authors.initials: N
authors.lastname: Habib
authors.forename: Jeremy
authors.initials: J
authors.lastname: Chataway
mesh_terms: D002460:Cell Line; D002986:Clinical Trials as Topic; D019650:Hematopoietic Stem Cell Mobilization; D006801:Humans; D059630:Mesenchymal Stem Cells / Q000502:physiology; D018919:Neovascularization, Physiologic / Q000502:physiology; D058953:Neural Stem Cells / Q000502:physiology; D055495:Neurogenesis / Q000502:physiology; D033581:Stem Cell Transplantation / Q000379:methods / Q000639:trends; D020521:Stroke / Q000628:therapy*; D057170:Translational Research, Biomedical; D016896:Treatment Outcome
keywords: clinical trials; stem cells; stroke