title: Circulating thrombotic and haemostatic components in patients with coronary artery disease.
abstract: The study aimed to analyze the circulating levels of thrombotic and haemostatic components; tissue factor, tissue factor pathway inhibitor, tissue plasminogen activator and plasminogen activator inhibitor-1 in patients with acute myocardial infarction at presentation (Group 1, n=49), unstable angina and Non-ST elevated MI after treatment (Group 2, n=22), stable angina (Group 3, n=18) and healthy individuals (Group 4, n=31). Significant finding was increase in tissue factor not only in Group 1 (2.0 fold, P=0.001), Group 2 (2.2 fold, P=0.015) but also in Group 3 (1.8 fold, P=0.018) as compared to controls. In Group 1 Plasminogen activator inhibitor-1 increased significantly (35.8%, P=0.02). Tissue factor pathway inhibitor and tissue plasminogen activator demonstrated increase in Group 1 of age<40 years while insignificant changes in elder patients. Increased thrombotic and decreased fibrinolytic conditions in acute myocardial infarction patients were observed. Increase TF in stable angina demonstrates procoagulant status in these patients as well.
authors.affiliation: H. N. Medical Research Society, Sir H. N. Hospital and Research Centre, Raja Rammohan Roy Road, Mumbai, 400 004 India.
authors.forename: Kavita K
authors.initials: KK
authors.lastname: Shalia
authors.forename: V K
authors.initials: VK
authors.lastname: Shah
authors.forename: M R
authors.initials: MR
authors.lastname: Mashru
authors.forename: S L
authors.initials: SL
authors.lastname: Soneji
authors.forename: J B
authors.initials: JB
authors.lastname: Vasvani
authors.forename: S S
authors.initials: SS
authors.lastname: Payannavar
authors.forename: A P
authors.initials: AP
authors.lastname: Walvalkar
authors.forename: R A
authors.initials: RA
authors.lastname: Mokal
authors.forename: S M
authors.initials: SM
authors.lastname: Mithbawkar
authors.forename: K V
authors.initials: KV
authors.lastname: Kudalkar
authors.forename: A
authors.initials: A
authors.lastname: Abraham
authors.forename: P K
authors.initials: PK
authors.lastname: Thakur
keywords: Acute Myocardial Infarction; Non-ST elevated MI; Stable angina; Thrombotic and haemostatic components