title: Subcutaneous Panniculitis-like T-cell lymphoma in two pediatric patients: an HIV-positive adolescent and a 4-month-old infant.
abstract: Subcutaneous Panniculitis-like T-cell lymphoma (SPTCL) is a rare subtype of childhood non-Hodgkin lymphoma. Subcutaneous Panniculitis-like T-cell lymphoma has an aggressive variant associated with the hemophagocytic syndrome (HPS). Patients without HPS show resolution of the disease with prednisone or immunosuppressive therapy unlike other T-cell lymphomas. One HIV-positive adolescent and one infant with multiple subcutaneous masses are presented and the literature is reviewed. Lesional cells were consistent with SPTCL alpha-beta type. Our cases, without HPS, showed complete resolution of their lesions when treated with non-aggressive therapies. Patients with SPTCL alpha-beta should be treated conservatively.
authors.affiliation: Department of Pathology, LAC+USC Medical Center, Los Angeles, California, USA.
authors.forename: Sara C
authors.initials: SC
authors.lastname: Acree
authors.forename: Jason P
authors.initials: JP
authors.lastname: Tovar
authors.forename: Paul K
authors.initials: PK
authors.lastname: Pattengale
authors.forename: Larry L
authors.initials: LL
authors.lastname: Wang
authors.forename: Joseph A
authors.initials: JA
authors.lastname: Church
authors.forename: Paul S
authors.initials: PS
authors.lastname: Gaynon
authors.forename: David S
authors.initials: DS
authors.lastname: Cassarino
mesh_terms: D000293:Adolescent; D044966:Anti-Retroviral Agents / Q000627:therapeutic use; D006679:HIV Seropositivity / Q000150:complications / Q000151:congenital / Q000188:drug therapy / Q000473:pathology*; D006801:Humans; D016867:Immunocompromised Host; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D007223:Infant; D016399:Lymphoma, T-Cell / Q000150:complications / Q000188:drug therapy / Q000473:pathology*; D008297:Male; D055118:Medication Adherence; D015434:Panniculitis / Q000150:complications / Q000188:drug therapy / Q000473:pathology*; D011241:Prednisone / Q000627:therapeutic use; D012074:Remission Induction; D016896:Treatment Outcome
chemical_list: D044966:Anti-Retroviral Agents; D007166:Immunosuppressive Agents; D011241:Prednisone