title: A/H5N1 prepandemic influenza vaccine (Vepacel®): a guide to its use.
abstract: Vepacel® is a prepandemic influenza vaccine (whole virion, Vero cell-derived, inactivated) containing antigen of H5N1 strain A/Vietnam/1203/2004 and is approved for use in the EU. Clinical immunogenicity studies with the vaccine have demonstrated good functional neutralizing antibody responses against the vaccine strain (A/Vietnam/1203/2004), and cross-reactivity against H5N1 strains from other clades. In general, adverse events observed in clinical immunogenicity studies with a whole virions H5N1 vaccine (A/Vietnam/1203/2004) were similar to those reported with non-adjuvanted, inactivated, split virion seasonal influenza vaccines.
authors.affiliation: Adis, Auckland, New Zealand. demail@springer.com
authors.forename: Gillian M
authors.initials: GM
authors.lastname: Keating
authors.forename: Greg L
authors.initials: GL
authors.lastname: Plosker
authors.forename: Katherine A
authors.initials: KA
authors.lastname: Lyseng-Williamson
mesh_terms: D000818:Animals; D002522:Chlorocebus aethiops; D002986:Clinical Trials as Topic; D006801:Humans; D053124:Influenza A Virus, H5N1 Subtype / Q000276:immunology*; D007252:Influenza Vaccines / Q000009:adverse effects / Q000276:immunology* / Q000627:therapeutic use*; D007251:Influenza, Human / Q000453:epidemiology / Q000276:immunology / Q000517:prevention & control*; D058873:Pandemics / Q000517:prevention & control; D017410:Practice Guidelines as Topic; D014709:Vero Cells; D014771:Virion / Q000276:immunology
chemical_list: D007252:Influenza Vaccines