title: Metabolic syndrome: a novel high-risk state for colorectal cancer.
abstract: Metabolic syndrome (MS) and related disorders, including cancer, are steadily increasing in most countries of the world. However, mechanisms underlying the link between MS and colon carcinogenesis have yet to be fully elucidated. In this review article we focus on the relationships between various individual associated conditions (obesity, dyslipidemia, diabetes mellitus type 2 and hypertension) and colon cancer development, and demonstrate probable related factors revealed by in vivo and in vitro studies. Furthermore, molecules suggested to be involved in cancer promotion are addressed, and the potential for cancer prevention by targeting these molecules is discussed.
authors.affiliation: Division of Cancer Development System, National Cancer Center Research Institute, 5-1-1 Tsukiji, Chuo-ku, Tokyo 104-0045, Japan.
authors.forename: Kousuke
authors.initials: K
authors.lastname: Ishino
authors.affiliation: Division of Cancer Prevention Research, National Cancer Center Research Institute, 5-1-1 Tsukiji, Chuo-ku, Tokyo 104-0045, Japan.
authors.forename: Michihiro
authors.initials: M
authors.lastname: Mutoh
authors.affiliation: Division of Cancer Development System, National Cancer Center Research Institute, 5-1-1 Tsukiji, Chuo-ku, Tokyo 104-0045, Japan.
authors.forename: Yukari
authors.initials: Y
authors.lastname: Totsuka
authors.affiliation: Division of Cancer Development System, National Cancer Center Research Institute, 5-1-1 Tsukiji, Chuo-ku, Tokyo 104-0045, Japan; Division of Cancer Prevention Research, National Cancer Center Research Institute, 5-1-1 Tsukiji, Chuo-ku, Tokyo 104-0045, Japan. Electronic address: hnakagam@ncc.go.jp.
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Nakagama
mesh_terms: D054392:Adipokines / Q000378:metabolism; D000809:Angiotensins / Q000378:metabolism; D015179:Colorectal Neoplasms / Q000209:etiology*; D003924:Diabetes Mellitus, Type 2 / Q000150:complications; D050171:Dyslipidemias / Q000150:complications; D006801:Humans; D006973:Hypertension / Q000150:complications; D007249:Inflammation / Q000150:complications / Q000378:metabolism; D024821:Metabolic Syndrome / Q000150:complications*; D009765:Obesity / Q000150:complications; D017382:Reactive Oxygen Species / Q000378:metabolism; D012083:Renin / Q000378:metabolism; D012307:Risk Factors
chemical_list: D054392:Adipokines; D000809:Angiotensins; D017382:Reactive Oxygen Species; D012083:Renin