title: Systemic inflammation, intraventricular hemorrhage, and white matter injury.
abstract: To see if the systemic inflammation profile of 123 infants born before the 28th week of gestation who had intraventricular hemorrhage without white matter injury differed from that of 68 peers who had both lesions, we compared both groups to 677 peers who had neither. Cranial ultrasound scans were read independently by multiple readers until concordance. The concentrations of 25 proteins were measured with multiplex arrays using an electrochemiluminescence system. Infants who had both hemorrhage and white matter injury were more likely than others to have elevated concentrations of C-reactive protein and interleukin 8 on days 1, 7, and 14, and elevated concentrations of serum amyloid A and tumor necrosis factor-α on 2 of these days. Intraventricular hemorrhage should probably be viewed as 2 entities: hemorrhage alone and hemorrhage with white matter injury. Each entity is associated with inflammation, but the combination has a stronger inflammatory signal than hemorrhage alone.
authors.affiliation: 1Department of Neurology, Children's Hospital, Boston, MA, USA.
authors.forename: Alan
authors.initials: A
authors.lastname: Leviton
authors.forename: Elizabeth N
authors.initials: EN
authors.lastname: Allred
authors.forename: Olaf
authors.initials: O
authors.lastname: Dammann
authors.forename: Stephen
authors.initials: S
authors.lastname: Engelke
authors.forename: Raina N
authors.initials: RN
authors.lastname: Fichorova
authors.forename: Deborah
authors.initials: D
authors.lastname: Hirtz
authors.forename: Karl C K
authors.initials: KC
authors.lastname: Kuban
authors.forename: Laura R
authors.initials: LR
authors.lastname: Ment
authors.forename: T Michael
authors.initials: TM
authors.lastname: O'shea
authors.forename: Nigel
authors.initials: N
authors.lastname: Paneth
authors.forename: Bhavesh
authors.initials: B
authors.lastname: Shah
authors.forename: Michael D
authors.initials: MD
authors.lastname: Schreiber
mesh_terms: D000367:Age Factors; D002097:C-Reactive Protein / Q000378:metabolism; D002543:Cerebral Hemorrhage / Q000000981:diagnostic imaging / Q000209:etiology*; D005260:Female; D005865:Gestational Age; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007234:Infant, Premature; D007235:Infant, Premature, Diseases / Q000000981:diagnostic imaging / Q000503:physiopathology*; D007249:Inflammation / Q000000981:diagnostic imaging / Q000209:etiology*; D016209:Interleukin-8 / Q000378:metabolism; D056784:Leukoencephalopathies / Q000000981:diagnostic imaging / Q000209:etiology*; D008297:Male; D016017:Odds Ratio; D000685:Serum Amyloid A Protein; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism; D018608:Ultrasonography, Doppler
chemical_list: D016209:Interleukin-8; D000685:Serum Amyloid A Protein; D014409:Tumor Necrosis Factor-alpha; D002097:C-Reactive Protein
keywords: acute; brain injuries; hemorrhage; inflammation; premature; white matter