title: Inotropic effects of gaseous transmitters in isolated rat heart preparation.
abstract: We studied the effects of carbon monoxide and sodium hydrosulfide, hydrogen sulfide donor, on contractile activity of the left ventricle in Langendorf-perfused isolated rat heart. Carbon monoxide 5×10(-5) M significantly accelerated sinus rhythm and left-ventricular pressure wave growth and decay. To the contrary, negative inotropic and chronotropic effects were observed at higher concentrations of carbon monoxide (10(-4), 3×10(-4) M). Sodium hydrosulfide (10(-4)-4×10(-4) M) decreased all the parameters of left-ventricular contractive activity and reduced contraction rate. Carbon monoxide and hydrogen sulfide, which together with nitrogen oxide are qualified as a new class of gaseous signal compounds, may substantially modulate pumping function of the heart.
authors.affiliation: Department of Human and Animal Physiology, M.V. Lomonosov Moscow State University, Moscow, Russia.
authors.forename: M V
authors.initials: MV
authors.lastname: Porokhya
authors.forename: D V
authors.initials: DV
authors.lastname: Abramochkin
authors.forename: A A
authors.initials: AA
authors.lastname: Abramov
authors.forename: V S
authors.initials: VS
authors.lastname: Kuzmin
authors.forename: G S
authors.initials: GS
authors.lastname: Sukhova
mesh_terms: D000818:Animals; D021461:Animals, Outbred Strains; D002248:Carbon Monoxide / Q000494:pharmacology*; D006339:Heart Rate / Q000187:drug effects*; D006352:Heart Ventricles / Q000187:drug effects*; D006862:Hydrogen Sulfide / Q000494:pharmacology*; D007260:Infusion Pumps; D008297:Male; D009200:Myocardial Contraction / Q000187:drug effects*; D009924:Organ Culture Techniques; D051381:Rats; D015398:Signal Transduction; D013440:Sulfides / Q000378:metabolism* / Q000494:pharmacology
chemical_list: D013440:Sulfides; D002248:Carbon Monoxide; C025451:sodium bisulfide; D006862:Hydrogen Sulfide