title: Neonatal alloimmune thrombocytopenia associated with massive chronic intervillositis: a case report and review of the literature.
abstract: Neonatal alloimmune thrombocytopenia (NAIT) presents as isolated thrombocytopenia in a normal neonate as a result of destruction of fetal platelets by maternal antibodies against paternally derived human platelet antigens. Neonatal alloimmune thrombocytopenia affects 0.1% of births, with maternal antibodies crossing the placenta as early as 14 weeks' gestation. Few reports describe placental histopathological changes occurring in NAIT cases. We present a case of NAIT associated with massive chronic intervillositis, a rare entity occurring in 0.06% to 0.8% of reviewed 2nd- and 3rd-trimester placentas; to our knowledge, this is the 1st report of such an association.
authors.affiliation: University of Texas Medical School at Houston Department of Pathology and Laboratory Medicine, Houston, TX, USA. Amanda.S.Tchakarov@uth.tmc.edu
authors.forename: Amanda
authors.initials: A
authors.lastname: Tchakarov
authors.forename: Amy
authors.initials: A
authors.lastname: Coffey
authors.forename: Nina
authors.initials: N
authors.lastname: Tatevian
mesh_terms: D000328:Adult; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D010922:Placenta Diseases / Q000473:pathology*; D011247:Pregnancy; D054098:Thrombocytopenia, Neonatal Alloimmune / Q000473:pathology*