title: Patterns of local recurrence after primary resection of cancers that arise in the sinonasal region and the maxillary alveolus.
abstract: Local recurrence remains the most important sign of relapse of disease after treatment of advanced cancer of the maxilla and sinonasal region. In this retrospective study we describe patterns of recurrence in a group of patients who had had open resection for cancer of the sinonasal region and posterior maxillary alveolus with curative intent. Casenotes and imaging studies were reviewed to find out the pattern of any relapse, with particular reference to local recurrence. The minimum follow-up period was 12 months. Of 50 patients a total of 16 developed recurrences, 11 of which were local. Of those 11, a total of 8 were in posterior and superior locations (the orbit, the infratemporal and pterygopalatine fossas, the traversing neurovascular canals of the body of the sphenoid to the cavernous sinus, the Gasserian ganglion, and the dura of the middle cranial fossa). Advanced cancer of the midface often equates with disease at the skull base. Treatment, including surgical tactics, should reflect that.
authors.affiliation: Southern General Hospital, Glasgow G51 4TF, United Kingdom. jeremymcmahon@nhs.net
authors.forename: Jeremy D
authors.initials: JD
authors.lastname: McMahon
authors.forename: Ling Siew
authors.initials: LS
authors.lastname: Wong
authors.forename: John
authors.initials: J
authors.lastname: Crowther
authors.forename: William M
authors.initials: WM
authors.lastname: Taylor
authors.forename: Joseph
authors.initials: J
authors.lastname: McManners
authors.forename: John C
authors.initials: JC
authors.lastname: Devine
authors.forename: Craig
authors.initials: C
authors.lastname: Wales
authors.forename: Colin
authors.initials: C
authors.lastname: Maciver
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000539:Alveolar Process / Q000473:pathology*; D000541:Alveolectomy / Q000379:methods; D002294:Carcinoma, Squamous Cell / Q000473:pathology / Q000601:surgery; D002426:Cavernous Sinus / Q000473:pathology; D003390:Cranial Nerve Neoplasms / Q000473:pathology; D004388:Dura Mater / Q000473:pathology; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008441:Maxillary Neoplasms / Q000601:surgery*; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000473:pathology*; D009367:Neoplasm Staging; D009918:Orbital Neoplasms / Q000473:pathology; D010255:Paranasal Sinus Neoplasms / Q000601:surgery*; D012189:Retrospective Studies; D016879:Salvage Therapy; D019292:Skull Base Neoplasms / Q000473:pathology; D012888:Skull Neoplasms / Q000473:pathology; D013100:Sphenoid Bone / Q000473:pathology; D015996:Survival Rate; D012668:Trigeminal Ganglion / Q000473:pathology; D055815:Young Adult