title: Determination of GABA(Aα1) and GABA          (B1) receptor subunits expression in tissues of gilts during the late gestation.
abstract: GABA(Aα1) and GABA(B1) receptor subunits are responsible for most behavioral, physiological and pharmacological effects of GABA receptors. We investigated the expression of GABA(Aα1) and GABA(B1) receptor subunits in different tissues of gilts during late pregnancy in hot summer. The mRNA abundance of GABA(Aα1) receptor subunit in different tissues of gilts at d 90 and d 110 of gestation was as follows: d 90: brain > lung > liver > ovary > spleen > kidney > heart; d 110: brain > lung > spleen > liver > ovary > kidney > heart. And, the mRNA abundance of GABA(B1) receptor subunit was as follows: d 90: spleen > lung > brain > kidney > ovary > liver > heart; d 110: spleen > lung > kidney > brain > ovary > liver > heart. The results in this trial indicated that the GABA(Aα1) receptor subunit was abundantly expressed in brain, while GABA(B1) receptor subunit was abundant in spleen and lung of gilts during late gestation. There were no gestation stage-dependent effects on GABA(Aα1) and GABA(B1) receptor subunits expression in all tissues.
authors.affiliation: Engineering Research Center for Feed Safety and Efficient Utilization of Ministry of Education, Institute of Animal Nutrition, Hunan Agricultural University, Changsha, 410128, Hunan, China. fzyong04@163.com
authors.forename: Zhiyong
authors.initials: Z
authors.lastname: Fan
authors.forename: Yonghui
authors.initials: Y
authors.lastname: Chen
authors.forename: Junjun
authors.initials: J
authors.lastname: Wang
authors.forename: Jinping
authors.initials: J
authors.lastname: Deng
authors.forename: Dexing
authors.initials: D
authors.lastname: Hou
authors.forename: Tiejun
authors.initials: T
authors.lastname: Li
authors.forename: Lingyuan
authors.initials: L
authors.lastname: Yang
authors.forename: Zhonghua
authors.initials: Z
authors.lastname: Liu
authors.forename: Xiaosong
authors.initials: X
authors.lastname: Wu
mesh_terms: D000818:Animals; D001921:Brain / Q000378:metabolism; D005260:Female; D015870:Gene Expression; D005786:Gene Expression Regulation; D005865:Gestational Age; D008168:Lung / Q000378:metabolism; D009928:Organ Specificity; D011247:Pregnancy / Q000378:metabolism*; D021122:Protein Subunits; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D011963:Receptors, GABA-A / Q000235:genetics* / Q000378:metabolism; D018080:Receptors, GABA-B / Q000235:genetics* / Q000378:metabolism; D013154:Spleen / Q000378:metabolism; D034421:Sus scrofa / Q000378:metabolism*
chemical_list: D021122:Protein Subunits; D012333:RNA, Messenger; D011963:Receptors, GABA-A; D018080:Receptors, GABA-B