title: Assessment of persistent organic pollutants levels in blood samples from Quintana Roo, Mexico.
abstract: The Stockholm Convention on persistent organic pollutants (POPs) sought to determine baseline exposures to POPs in the general population; however, in developing countries, exposure to these chemicals in hot spots may be an issue of public health considering its magnitude. Therefore, the aim of this study was to assess the levels of POPs in the blood of children living in three communities in the Southeastern Region of Mexico. During 2007, we studied a total of 96 healthy children (aged 6-12 years). Quantitative analyses were performed using gas chromatography coupled with mass spectrometry. High levels of p,p'-DDT and its principal metabolite, p,p'-DDE, were found in the blood of children living in the three communities studied, the levels ranged from 463.5 to 9046.3 ng/g lipid and from 490.8 to 57,712.4 ng/g lipid for DDT and DDE, respectively. In addition, high levels of lindane (γ-HCH) were found, with mean levels ranging between 575.4 and 6580.6 ng/g lipid. Moreover, children living in the study region were also exposed to polychlorinated biphenyls (PCBs), and the levels of these compounds in the blood of children were very similar between the communities with mean levels of around 3000 ng/g lipid (total PCBs). In conclusion, we demonstrated that children living in the studied communities were exposed to complex chemical mixtures (DDT, DDE, lindane and PCBs) rather than to individual compounds. Therefore, in future studies it is important to understand the potential interactions between the components of these mixtures.
authors.affiliation: Departamento Toxicología Ambiental, Facultad de Medicina, Universidad Autónoma de San Luis Potosí, San Luis Potosí, Mexico.
authors.forename: Trejo-Acevedo
authors.initials: TA
authors.lastname: Antonio
authors.forename: Rivero-Pérez Norma
authors.initials: RP
authors.lastname: Edith
authors.forename: Flores-Ramírez
authors.initials: FR
authors.lastname: Rogelio
authors.forename: Díaz-Barriga
authors.initials: DB
authors.lastname: Fernando
authors.forename: Ochoa Angeles
authors.initials: OA
authors.lastname: Catalina
authors.forename: Pérez-Maldonado Iván
authors.initials: PM
authors.lastname: Nelinho
mesh_terms: D002648:Child; D004784:Environmental Monitoring; D004785:Environmental Pollutants / Q000097:blood*; D005260:Female; D006801:Humans; D006843:Hydrocarbons, Chlorinated / Q000097:blood*; D007306:Insecticides / Q000097:blood*; D008297:Male; D008800:Mexico
chemical_list: D004785:Environmental Pollutants; D006843:Hydrocarbons, Chlorinated; D007306:Insecticides