title: Olanzapine induced de-novo obsessive compulsive disorder in a patient with schizophrenia.
abstract: There are reports of de novo development or exacerbation of obsessive-compulsive symptoms in patients with schizophrenia treated with atypical antipsychotics, although this is widely debated. We report one such case where a patient with a primary diagnosis of schizophrenia, treated with olanzapine, developed de novo obsessive-compulsive disorder, with convincing evidence for its causality due to the drug.
authors.affiliation: Department of Psychiatry, National Institute of Mental Health and Neurosciences (NIMHANS), Bangalore, Karnataka, India.
authors.forename: Gajanan
authors.initials: G
authors.lastname: Kulkarni
authors.forename: Janardhanan C
authors.initials: JC
authors.lastname: Narayanaswamy
authors.forename: Suresh Bada
authors.initials: SB
authors.lastname: Math
mesh_terms: D000328:Adult; D014150:Antipsychotic Agents / Q000009:adverse effects*; D001569:Benzodiazepines / Q000009:adverse effects*; D005260:Female; D006801:Humans; D009771:Obsessive-Compulsive Disorder / Q000139:chemically induced* / Q000175:diagnosis*; D000077152:Olanzapine; D012559:Schizophrenia / Q000188:drug therapy*
chemical_list: D014150:Antipsychotic Agents; D001569:Benzodiazepines; D000077152:Olanzapine
keywords: Obsessive-compulsive disorder; olanzapine; schizophrenia