title: A proposal for an upper limit of leucine safe intake in healthy adults.
abstract: Based on recent research, an upper limit of safe intake (ULSI) for leucine is proposed for healthy adults: 0.53 g/(kg·d). Because leucine has been used as a dietary supplement for many years in people practicing exercise and sport, further study with long-term exposure to leucine in this specific subpopulation should be performed to eventually adjust the ULSI.
authors.affiliation: Clinical Chemistry Laboratory, Cochin and Hôtel-Dieu Hospitals, AP-HP, Paris, France. solange.ngon@cch.aphp.fr
authors.forename: Luc
authors.initials: L
authors.lastname: Cynober
authors.forename: Dennis M
authors.initials: DM
authors.lastname: Bier
authors.forename: Motoni
authors.initials: M
authors.lastname: Kadowaki
authors.forename: Sidney M
authors.initials: SM
authors.lastname: Morris
authors.forename: Andrew G
authors.initials: AG
authors.lastname: Renwick
mesh_terms: D000328:Adult; D000818:Animals; D019587:Dietary Supplements; D006801:Humans; D007930:Leucine / Q000008:administration & dosage*; D008297:Male; D018673:Nutrition Policy; D009751:Nutritional Requirements; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D007930:Leucine