title: A step closer to personalized chemotherapy: consideration of the influence of genetic variation in hepatic uptake transporters on the metabolism of CYP3A substrates.
abstract: Understanding the metabolic, transporter, and genetic influences on the disposition of drugs used in chemotherapy is critical to individualization of drug therapy. Recognition of the importance of transporter-enzyme interplay, in which genetic variants of drug uptake transporters can change drug metabolism when the enzymes are unchanged, is an important advance in predicting appropriate drug dosage regimens for the individual patient.
authors.affiliation: Department of Bioengineering and Therapeutic Sciences, Schools of Pharmacy and Medicine, University of California, San Francisco, USA. leslie.benet@ucsf.edu
authors.forename: L Z
authors.initials: LZ
authors.lastname: Benet
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000493:pharmacokinetics*; D004917:Erythromycin / Q000493:pharmacokinetics*; D005260:Female; D006801:Humans; D027381:Liver-Specific Organic Anion Transporter 1; D008297:Male; D027361:Organic Anion Transporters / Q000235:genetics*; D029362:Organic Anion Transporters, Sodium-Independent / Q000235:genetics*
chemical_list: D000900:Anti-Bacterial Agents; D027381:Liver-Specific Organic Anion Transporter 1; D027361:Organic Anion Transporters; D029362:Organic Anion Transporters, Sodium-Independent; C503999:SLCO1B1 protein, human; C498887:Slco1b2 protein, mouse; D004917:Erythromycin