title: Venlafaxine and risk of upper gastrointestinal bleeding in elderly depression.
abstract: In the past 10 years there has been an emphasis on the risk of upper gastrointestinal bleeding in patients taking SSRI antidepressants. Few studies have concurrently examined the possible risk of traditional antidepressants or atypical antidepressants such as venlafaxine, classified as a serotonin-norepinephrine reuptake inhibitor. In order to promote debate about possible risk of upper gastrointestinal bleeding in elderly patients taking antidepressants different from SSRIs, we report a case of venlafaxine-induced upper gastrointestinal bleeding in a 84 years old woman. Discussion about safer drugs and protective factors is provided.
authors.affiliation: IRCCS University Hospital San Martino – IST, Genoa, Italy. lu.ghio@libero.it
authors.forename: Lucio
authors.initials: L
authors.lastname: Ghio
authors.forename: Serena
authors.initials: S
authors.lastname: Puppo
authors.forename: Andrea
authors.initials: A
authors.lastname: Presta
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D018687:Antidepressive Agents, Second-Generation / Q000009:adverse effects*; D003511:Cyclohexanols / Q000009:adverse effects*; D003863:Depression / Q000188:drug therapy*; D005260:Female; D006471:Gastrointestinal Hemorrhage / Q000139:chemically induced*; D006801:Humans; D017367:Selective Serotonin Reuptake Inhibitors / Q000009:adverse effects*; D000069470:Venlafaxine Hydrochloride
chemical_list: D018687:Antidepressive Agents, Second-Generation; D003511:Cyclohexanols; D017367:Selective Serotonin Reuptake Inhibitors; D000069470:Venlafaxine Hydrochloride