title: Statin use and association with colorectal cancer survival and risk: case control study with prescription data linkage.
abstract: BACKGROUND
  In Scotland colorectal cancer (CRC) is the third most common cancer and a leading cause of cancer death. Epidemiological studies have reported conflicting associations between statins and CRC risk and there is one published report of the association between statins and CRC survival.
  
  
  METHODS
  Analysis was carried out on 309 cases and 294 controls from the Scottish Study of Colorectal Cancer (SOCCS). Cox's hazard and logistic regression models were applied to investigate the association between statin use and CRC risk and survival.
  
  
  RESULTS
  In an adjusted logistic regression model, statins were found to show a statistically significant association for three of the four statin variables and were found to not show a statistically significant association with either all-cause or CRC-specific mortality (OR 0.49; 95%CI 0.49-1.36; p-value = 0.17 and OR 0.33; 95%CI 0.08-1.35; P-value = 0.12, respectively).
  
  
  CONCLUSIONS
  We did find a statistically significant association between statin intake and CRC risk but not statin intake and CRC-specific mortality. However, the study was insufficiently powered and larger scale studies may be advisable.
authors.affiliation: Centre for Population Health Sciences, University of Edinburgh, Teviot Place, Edinburgh, EH8 9AG, UK. fatim.lakha@nhs.net
authors.forename: Fatim
authors.initials: F
authors.lastname: Lakha
authors.forename: Evropi
authors.initials: E
authors.lastname: Theodoratou
authors.forename: Susan M
authors.initials: SM
authors.lastname: Farrington
authors.forename: Albert
authors.initials: A
authors.lastname: Tenesa
authors.forename: Roseanne
authors.initials: R
authors.lastname: Cetnarskyj
authors.forename: Farhat V N
authors.initials: FV
authors.lastname: Din
authors.forename: Mary E
authors.initials: ME
authors.lastname: Porteous
authors.forename: Malcolm G
authors.initials: MG
authors.lastname: Dunlop
authors.forename: Harry
authors.initials: H
authors.lastname: Campbell
mesh_terms: D016022:Case-Control Studies; D015179:Colorectal Neoplasms / Q000453:epidemiology* / Q000401:mortality; D005260:Female; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000008:administration & dosage* / Q000009:adverse effects; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D016016:Proportional Hazards Models; D012306:Risk; D012606:Scotland / Q000453:epidemiology
chemical_list: D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors