title: Experimental aspects of colloidal interactions in mixed systems of liposome and inorganic nanoparticle and their applications.
abstract: In the past few years, growing attention has been devoted to the study of the interactions taking place in mixed systems of phospholipid membranes (for instance in the form of vesicles) and hard nanoparticles (NPs). In this context liposomes (vesicles) may serve as versatile carriers or as a model system for biological membranes. Research on these systems has led to the observation of novel hybrid structures whose morphology strongly depends on the charge, composition and size of the interacting colloidal species as well as on the nature (pH, ionic strength) of their dispersing medium. A central role is played by the phase behaviour of phospholipid bilayers which have a tremendous influence on the liposome properties. Another central aspect is the incorporation of nanoparticles into vesicles, which is intimately linked to the conditions required for transporting a nanoparticle through a membrane. Herein, we review recent progress made on the investigations of the interactions in liposome/nanoparticle systems focusing on the particularly interesting structures that are formed in these hybrid systems as well as their potential applications.
authors.affiliation: Stranski-Laboratorium für Physikalische und Theoretische Chemie, Institut für Chemie, Technische Universität Berlin, Berlin D-10623, Germany.
authors.forename: Raphael
authors.initials: R
authors.lastname: Michel
authors.affiliation: Stranski-Laboratorium für Physikalische und Theoretische Chemie, Institut für Chemie, Technische Universität Berlin, Berlin D-10623, Germany.
authors.forename: Michael
authors.initials: M
authors.lastname: Gradzielski
mesh_terms: D003102:Colloids / Q000737:chemistry*; D057927:Hydrophobic and Hydrophilic Interactions; D008051:Lipid Bilayers / Q000737:chemistry; D008081:Liposomes / Q000737:chemistry*; D053758:Nanoparticles / Q000737:chemistry*; D009994:Osmolar Concentration; D010743:Phospholipids / Q000737:chemistry*
chemical_list: D003102:Colloids; D008051:Lipid Bilayers; D008081:Liposomes; D010743:Phospholipids
keywords: bilayer; colloidal stabilization; decorated vesicles; encapsulation; internalization; liposome; nanoparticle; small unilamellar vesicle (SUV); supported lipid bilayer