title: Transfer of carboplatin and paclitaxel into breast milk.
abstract: Carboplatin is an alkylating agent that is FDA approved for the treatment of advanced ovarian cancer. Paclitaxel is a plant taxane mitotic inhibitor approved for primary or salvage treatment of ovarian and breast cancer. This is a case report of a 40-year-old woman who was exclusively breastfeeding prior to being treated for papillary thyroid cancer with intravenous carboplatin (233 mg) and intravenous paclitaxel (30 mg/m(2)) for 6 consecutive weeks. Breast milk samples were collected during the sixth chemotherapy session. Carboplatin had a relative infant dose of 2.0% and remained measurable after 316 hours. Paclitaxel had a relative infant dose of 16.7% but was eliminated before 316 hours. The potential side effects of infant exposure of these medications include myelosuppression, hypersensitivity reactions, nephrotoxicity, and neurotoxicity. It would be inadvisable for a mother to breastfeed while undergoing therapy with these 2 medications.
authors.affiliation: Texas Tech University Health Sciences Center at Amarillo, Amarillo, TX 79106, USA.
authors.forename: Stephen J
authors.initials: SJ
authors.lastname: Griffin
authors.forename: Maria
authors.initials: M
authors.lastname: Milla
authors.forename: Teresa E
authors.initials: TE
authors.lastname: Baker
authors.forename: Tianjia
authors.initials: T
authors.lastname: Liu
authors.forename: Hongyan
authors.initials: H
authors.lastname: Wang
authors.forename: Thomas W
authors.initials: TW
authors.lastname: Hale
mesh_terms: D000328:Adult; D000970:Antineoplastic Agents / Q000493:pharmacokinetics* / Q000627:therapeutic use; D016190:Carboplatin / Q000493:pharmacokinetics* / Q000627:therapeutic use; D002277:Carcinoma / Q000188:drug therapy; D002291:Carcinoma, Papillary; D002851:Chromatography, High Pressure Liquid; D005260:Female; D006801:Humans; D007774:Lactation / Q000378:metabolism*; D008895:Milk, Human / Q000737:chemistry*; D017239:Paclitaxel / Q000493:pharmacokinetics* / Q000627:therapeutic use; D000077273:Thyroid Cancer, Papillary; D013964:Thyroid Neoplasms / Q000188:drug therapy
chemical_list: D000970:Antineoplastic Agents; D016190:Carboplatin; D017239:Paclitaxel