title: Serum thioredoxin 1 level has close relation with myocardial damage amount in acute myocardial infarction patients.
abstract: Thioredoxin-1 (Trx-1) is one of important anti-oxidative molecules to overcome the oxidative stress. The aim of the present study is to investigate the clinical relationship between serum concentration of Trx-1 on the pre-percutaneous coronary intervention (prePCI) and myocardial damage amount in the patients with acute myocardial infarction with the culprit lesion in only the left anterior descending artery on coronary angiography (n = 100). Initial value of creatine kinase (CK) was 368.3 ± 531.4 U/L, and MB isoenzyme of CK (CK-MB) level was 22.92 ± 33.8 ng/mL, and cardiac specific troponin T (cTnT) level was 0.61 ± 1.6 ng/mL. Positive correlations were observed between prePCI Trx-1 level and initial CK (P = 0.005, r = 0.281), and cTnT (P < 0.001, r = 0.453), peak CK (P = 0.001, r = 0.316) in all patients, but the statistical relation was observed only in ST segment elevation myocardial infarction (STEMI) patients (P = 0.008, r = 0.329 for initial CK, P = 0.001, r = 0.498 for initial cTnT, P = 0.005, r = 0.349 for peak CK), not in Non-STEMI patients. Conclusively, we consider prePCI serum Trx-1 as a predictor for myocardial damage amount in patients with STEMI.
authors.affiliation: Regional Cardiovascular Disease Center, Division of Cardiology, Department of Internal Medicine, Chungbuk National University Hospital, Cheongju, Korea.
authors.forename: Young Kwang
authors.initials: YK
authors.lastname: Shim
authors.forename: Jeong-Tae
authors.initials: JT
authors.lastname: Kim
authors.forename: Mun-Hyuk
authors.initials: MH
authors.lastname: Seong
authors.forename: Yeon-Jeong
authors.initials: YJ
authors.lastname: Kim
authors.forename: Tae-Jin
authors.initials: TJ
authors.lastname: Shim
authors.forename: Sang Min
authors.initials: SM
authors.lastname: Kim
authors.forename: Sang Yeub
authors.initials: SY
authors.lastname: Lee
authors.forename: Jang-Whan
authors.initials: JW
authors.lastname: Bae
authors.forename: Ki-Seok
authors.initials: KS
authors.lastname: Kim
authors.forename: Kyung-Kuk
authors.initials: KK
authors.lastname: Hwang
authors.forename: Dong-Woon
authors.initials: DW
authors.lastname: Kim
authors.forename: Myeong-Chan
authors.initials: MC
authors.lastname: Cho
mesh_terms: D000208:Acute Disease; D000328:Adult; D000368:Aged; D015415:Biomarkers / Q000097:blood; D017023:Coronary Angiography; D003402:Creatine Kinase / Q000097:blood; D052279:Creatine Kinase, MB Form / Q000097:blood; D004452:Echocardiography; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000097:blood* / Q000473:pathology; D009206:Myocardium / Q000473:pathology*; D062645:Percutaneous Coronary Intervention; D013879:Thioredoxins / Q000097:blood*; D020107:Troponin T / Q000097:blood
chemical_list: D015415:Biomarkers; D020107:Troponin T; D013879:Thioredoxins; D003402:Creatine Kinase; D052279:Creatine Kinase, MB Form
keywords: Biochemical Markers; Myocardial Infarction; Oxidative Stress; Thioredoxins