title: [Postoperative dynamic changes in matrix metalloproteinase levels in patients with coronary artery bypass graft procedure complications].
abstract: The purpose of  this study was to evaluate diagnostic and prognostic value of matrix metalloproteinases in postoperative complication development after on-pump coronary artery bypass grafting. 29 coronary artery disease patients who had undergone on-pump coronary artery bypass grafting were examined, 4 of those had complicated systemic inflammatory response and 5 of those had isolated renal failure. Serum matrix metalloproteinase/tissue inhibitor of matrix metalloproteinase concentrations were measured before surgery, at day 1 and day 7 after surgery. Postoperative period was found to be characterized by higher levels of serum matrix metalloproteinases (MMP-9, proMMP-1) and lower levels of matrix metalloproteinase 1 tissue inhibitor. Complicated systemic inflammatory response was associated with higher levels of MMP-9, MMP-3 and proMMP-1, on particular, at day 7.
authors.forename: A S
authors.initials: AS
authors.lastname: Golovkin
authors.forename: V G
authors.initials: VG
authors.lastname: Matveeva
authors.forename: E V
authors.initials: EV
authors.lastname: Grigor'ev
authors.forename: Iu V
authors.initials: IuV
authors.lastname: Baĭrakova
authors.forename: D L
authors.initials: DL
authors.lastname: Shukevich
authors.forename: E A
authors.initials: EA
authors.lastname: Velikanova
authors.forename: O L
authors.initials: OL
authors.lastname: Barbarash
mesh_terms: D001026:Coronary Artery Bypass / Q000009:adverse effects* / Q000379:methods; D006801:Humans; D020782:Matrix Metalloproteinases / Q000097:blood*; D017202:Myocardial Ischemia / Q000378:metabolism / Q000601:surgery*; D011182:Postoperative Care / Q000379:methods; D011183:Postoperative Complications / Q000097:blood*; D011237:Predictive Value of Tests; D011379:Prognosis; D051437:Renal Insufficiency / Q000097:blood / Q000209:etiology; D018746:Systemic Inflammatory Response Syndrome / Q000097:blood / Q000209:etiology; D013997:Time Factors
chemical_list: D020782:Matrix Metalloproteinases