title: Comparison of two ovarian malignancy prediction models based on age sonographic findings and serum CA125 measurement.
abstract: OBJECTIVE
  The aim of our study is to compare an ovarian malignancy prediction model based on age and four sonographic findings (OMPS1) with a new model called OMPS2 which differs just by adding serum CA125 measurement to (OMPS1).
  
  
  METHODS
  In a cross sectional comparative study OMPS1 was validated in 830 operated ovarian masses within a 3 years period (2006-2009). Logistic regression analysis was used to construct OMPS2 based on OMPS1 adding serum CA125 findings. The area under the curve for two models was compared in 411 patients.
  
  
  RESULTS
  OMPS2 was calculated as follows: OMPS1 + 1.444 (if serum CA125= 36-200) or 3.842 (if serum CA125 is more than 200). AUC of OMPS2 was increased to 84.3% (CI 95% 78.1- 89.8) in comparison to OMPS1 with AUC of 78.1% (CI 95% 71.8-84.5).
  
  
  CONCLUSIONS
  Our second model is more accurate in prediction of ovarian malignancy, compared with our first model.
authors.affiliation: Gynecology-Oncology, Imam Hossein Medical Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran. drmarab@yahoo.com
authors.forename: Maliheh
authors.initials: M
authors.lastname: Arab
authors.forename: Mehdi
authors.initials: M
authors.lastname: Yaseri
authors.forename: Tahereh
authors.initials: T
authors.lastname: Ashrafganjoi
authors.forename: Maryam
authors.initials: M
authors.lastname: Maktabi
authors.forename: Giti
authors.initials: G
authors.lastname: Noghabaee
authors.forename: Kourosh
authors.initials: K
authors.lastname: Sheibani
mesh_terms: D000291:Adnexal Diseases / Q000097:blood / Q000000981:diagnostic imaging / Q000453:epidemiology*; D000328:Adult; D014408:Biomarkers, Tumor / Q000097:blood*; D018394:CA-125 Antigen / Q000097:blood*; D003430:Cross-Sectional Studies; D005260:Female; D006305:Health Status Indicators; D006801:Humans; D016015:Logistic Models; D008875:Middle Aged; D015233:Models, Statistical; D010051:Ovarian Neoplasms / Q000097:blood / Q000000981:diagnostic imaging / Q000453:epidemiology*; D011379:Prognosis; D012372:ROC Curve; D063127:Secondary Health Care; D062606:Tertiary Care Centers; D014463:Ultrasonography
chemical_list: D014408:Biomarkers, Tumor; D018394:CA-125 Antigen