title: Anti-inflammatory effects and acute toxicity of hydroethanolic extract of Jacaranda decurrens roots in adult male rats.
abstract: BACKGROUND
  Jacaranda decurrens subsp. symmetrifoliolata Farias and Proença (Bignoniaceae) is a species traditionally used for the treatment of inflammatory diseases. However, until this moment, there is no scientific evidence of these effects.
  
  
  OBJECTIVE
  To evaluate the anti-inflammatory effects of hydroethanolic root extract of Jacaranda decurrens in rats and to determine the safe of this plant after acute exposure.
  
  
  METHODS
  The acute toxicity of Jacaranda decurrens root extract (EJD) was evaluated by oral administration to male rats as single doses of 0; 500; 1000 or 2000 mg/kg body weight. General behavior and toxic symptoms were observed for 14 days. The anti-inflammatory activity was evaluated in carrageenan-induced inflammatory paw edema and myeloperoxidase activity in male rats.
  
  
  RESULTS
  No signs of acute toxicity were observed, indicating that the LD(50) is greater than 2000 mg/kg. EJD (100 and 300 mg/kg) significantly reduced edema formation and at higher dose, the reduction was similar to dexamethasone. A significant decrease in myeloperoxidase activity was also observed.
  
  
  CONCLUSIONS
  The present study shows that Jacaranda decurrens extract has anti-inflammatory properties in rats without causing acute toxicity. These properties observed may be due to the presence of bioactive constituents such as ursolic acid.
authors.affiliation: School of Health Sciences, Federal University of Grande Dourados, Dourados-MS, Brazil.
authors.forename: Joyce Alencar
authors.initials: JA
authors.lastname: Santos
authors.forename: Aline
authors.initials: A
authors.lastname: Arruda
authors.forename: Magaiver Andrade
authors.initials: MA
authors.lastname: Silva
authors.forename: Claudia Andrea Lima
authors.initials: CA
authors.lastname: Cardoso
authors.forename: Maria do Carmo
authors.initials: Mdo C
authors.lastname: Vieira
authors.forename: Cândida Aparecida Leite
authors.initials: CA
authors.lastname: Kassuya
authors.forename: Arielle Cristina
authors.initials: AC
authors.lastname: Arena
mesh_terms: D000085:Acetates / Q000737:chemistry; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use*; D029402:Bignoniaceae; D002351:Carrageenan; D004487:Edema / Q000139:chemically induced / Q000188:drug therapy* / Q000201:enzymology; D000431:Ethanol / Q000737:chemistry; D008297:Male; D000432:Methanol / Q000737:chemistry; D009195:Peroxidase / Q000378:metabolism; D008517:Phytotherapy; D010936:Plant Extracts / Q000627:therapeutic use*; D018517:Plant Roots; D051381:Rats; D017208:Rats, Wistar; D012997:Solvents / Q000737:chemistry; D023382:Toxicity Tests, Acute; D014867:Water / Q000737:chemistry
chemical_list: D000085:Acetates; D000893:Anti-Inflammatory Agents; D010936:Plant Extracts; D012997:Solvents; D014867:Water; D000431:Ethanol; C007650:ethyl acetate; D002351:Carrageenan; D009195:Peroxidase; D000432:Methanol