title: Characterization of the Solutol® HS15/water phase diagram and the impact of the Δ9-tetrahydrocannabinol solubilization.
abstract: Here, the phase behavior of the commercial non-ionic surfactant Solutol® HS15 in water was investigated. The focus was on the evolution of the system nanostructure at low water content. Particularly, it was demonstrated that spherical micelles found in dilute surfactant solutions coalesce at a surfactant volume fraction close to 0.5. As consequence, a heterogeneous pseudo-binary mixture occurs. No liquid crystalline phases were detected even at the highest HS15 concentrations in water. Alteration of the micellar morphology induced by the addition of Δ(9)-tetrahydrocannabinol to the surfactant/water binary system was also investigated. It was found that the cannabinoid molecules become entrapped within the surfactant hydrophobic tails, thus increasing the surfactant effective packing parameter and inducing a radical change of the micelle shape. At sufficiently low water content (18-35 wt.%), such alteration of the interfacial packing results in a lamellar organization of the surfactant molecules.
authors.affiliation: Department of Chemical and Geological Science, University of Cagliari, CNBS and CSGI, Monserrato (CA), Italy. murgias@unica.it
authors.forename: Sergio
authors.initials: S
authors.lastname: Murgia
authors.forename: Paolo
authors.initials: P
authors.lastname: Fadda
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Colafemmina
authors.forename: Ruggero
authors.initials: R
authors.lastname: Angelico
authors.forename: Luigi
authors.initials: L
authors.lastname: Corrado
authors.forename: Paolo
authors.initials: P
authors.lastname: Lazzari
authors.forename: Maura
authors.initials: M
authors.lastname: Monduzzi
authors.forename: Gerardo
authors.initials: G
authors.lastname: Palazzo
mesh_terms: D013759:Dronabinol / Q000737:chemistry*; D008823:Micelles; D049329:Nanostructures / Q000737:chemistry*; D011092:Polyethylene Glycols / Q000737:chemistry*; D012995:Solubility; D013229:Stearic Acids / Q000737:chemistry*; D014867:Water / Q000737:chemistry*
chemical_list: D008823:Micelles; D013229:Stearic Acids; D014867:Water; D011092:Polyethylene Glycols; C067028:Solutol HS 15; D013759:Dronabinol