title: Palladium-catalyzed synthesis of isocoumarins and phthalides via tert-butyl isocyanide insertion.
abstract: A novel and highly efficient strategy for the synthesis of isocoumarins and phthalides through a palladium(0)-catalyzed reaction incorporating tert-butyl isocyanide has been developed. This process, providing one of the simplest methods for the synthesis of this class of valuable lactones, involves two steps including cyclization reaction and simple acid hydrolysis. The methodology is tolerant of a wide range of substrates and applicable to library synthesis.
authors.affiliation: College of Pharmaceutical Sciences, Soochow University, Suzhou, 215123, China.
authors.forename: Xiang-Dong
authors.initials: XD
authors.lastname: Fei
authors.forename: Zhi-Yuan
authors.initials: ZY
authors.lastname: Ge
authors.forename: Ting
authors.initials: T
authors.lastname: Tang
authors.forename: Yong-Ming
authors.initials: YM
authors.lastname: Zhu
authors.forename: Shun-Jun
authors.initials: SJ
authors.lastname: Ji
mesh_terms: D001572:Benzofurans / Q000138:chemical synthesis* / Q000737:chemistry*; D002384:Catalysis; D003500:Cyclization; D006868:Hydrolysis; D049934:Isocoumarins / Q000138:chemical synthesis* / Q000737:chemistry*; D007783:Lactones / Q000737:chemistry*; D015394:Molecular Structure; D009570:Nitriles / Q000737:chemistry*; D010165:Palladium
chemical_list: D001572:Benzofurans; D049934:Isocoumarins; D007783:Lactones; D009570:Nitriles; D010165:Palladium; C099535:tert-butyl isocyanide; C082022:phthalide