title: Delayed effects of NMDA receptor antagonist MK-801 on storage and reconsolidation of spatial memory in rats.
abstract: We studied the effects of NMDA receptor antagonist MK-801 on the storage and reconsolidation of spatial memory in Morris water maze in adult rats. MK-801 (50 μg/kg) administered 24 h after the completion of training was shown to improve the resistance of spatial memory to spontaneous extinction, while reminder against the background of MK-801 suppresses its ameliorating effect on memory storage. The detected behavioral effects of MK-801 persisted over 60 days after administration and can be associated with its influence on coupled neurogenesis/apoptosis processes induced during memory trace formation in adult animals.
authors.affiliation: PK Anokhin Institute of Normal Physiology, Russian Academy of Medical Sciences, Moscow, Russia. storozheva_zi@mail.ru
authors.forename: Z I
authors.initials: ZI
authors.lastname: Storozheva
authors.forename: O A
authors.initials: OA
authors.lastname: Solovieva
authors.forename: A T
authors.initials: AT
authors.lastname: Proshin
authors.forename: V V
authors.initials: VV
authors.lastname: Sherstnev
mesh_terms: D000818:Animals; D017209:Apoptosis / Q000187:drug effects / Q000502:physiology; D016291:Dizocilpine Maleate / Q000494:pharmacology*; D008297:Male; D018782:Maze Learning / Q000187:drug effects* / Q000502:physiology; D008568:Memory / Q000187:drug effects* / Q000502:physiology; D055495:Neurogenesis / Q000187:drug effects / Q000502:physiology; D051381:Rats; D017208:Rats, Wistar; D016194:Receptors, N-Methyl-D-Aspartate / Q000037:antagonists & inhibitors*; D013028:Space Perception / Q000187:drug effects* / Q000502:physiology; D018709:Statistics, Nonparametric
chemical_list: D016194:Receptors, N-Methyl-D-Aspartate; D016291:Dizocilpine Maleate