title: Synthesis and antibacterial activity of new fluoroquinolones containing a cis- or trans-cyclohexane moiety.
abstract: New quinolone derivatives bearing a cis- or trans-cyclohexane side chain at the C-7 position have been synthesized and evaluated for their antibacterial activities against Staphylococcus aureus, Escherichia coli, and Pseudomonas aeruginosa using the agar dilution method. The activities of compound 53 against these three bacteria were superior to those of the reference drug lomefloxacin. Compounds bearing a cis-cyclohexane side chain generally exhibited greater antibacterial activity than their corresponding trans-isomers.
authors.affiliation: Key Laboratory of Drug-Targeting and Drug-Delivery Systems of Ministry of Education, Department of Medicinal Chemistry, West China School of Pharmacy, Sichuan University, Chengdu, Sichuan 610041, PR China.
authors.forename: Qing-Rong
authors.initials: QR
authors.lastname: Qi
authors.forename: Jia
authors.initials: J
authors.lastname: Pan
authors.forename: Xiao-Qiang
authors.initials: XQ
authors.lastname: Guo
authors.forename: Ling-Ling
authors.initials: LL
authors.lastname: Weng
authors.forename: Yu-Feng
authors.initials: YF
authors.lastname: Liang
mesh_terms: D000900:Anti-Bacterial Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D003510:Cyclohexanes / Q000737:chemistry*; D004305:Dose-Response Relationship, Drug; D004926:Escherichia coli / Q000187:drug effects*; D024841:Fluoroquinolones / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D011550:Pseudomonas aeruginosa / Q000187:drug effects*; D013211:Staphylococcus aureus / Q000187:drug effects*; D013237:Stereoisomerism; D013329:Structure-Activity Relationship
chemical_list: D000900:Anti-Bacterial Agents; D003510:Cyclohexanes; D024841:Fluoroquinolones; C506365:Cyclohexane