title: Oxidant-antioxidant status in colorectal cancer patients-Before and after treatment.
abstract: Erythrocyte antioxidant glutathione and malondialdehyde levels in erythrocytes and plasma glutathione S-transferase levels were estimated in patients with colorectal cancer and compared to controls. Further, the patients underwent four weeks of radiotherapy with adjuvant chemotherapy. The same parameters were estimated after four weeks of radiotherapy and compared with pretreatment levels. It was observed that there was a decrease in erythrocyte glutathione and malondialdehyde levels in patients with colorectal cancer compared to controls, but not in case of GST. However, after chemoradiotherapy, there were no statistically significant differences in all the parameters studied.
authors.affiliation: Department of Biochemistry, Kasturba Medical College, 576 104 Manipal, India.
authors.forename: Sharmila
authors.initials: S
authors.lastname: Upadhya
authors.forename: Subramanya
authors.initials: S
authors.lastname: Upadhya
authors.forename: S Krishna
authors.initials: SK
authors.lastname: Mohan
authors.forename: K
authors.initials: K
authors.lastname: Vanajakshamma
authors.forename: Mamatha
authors.initials: M
authors.lastname: Kunder
authors.forename: Seema
authors.initials: S
authors.lastname: Mathias
keywords: Colorectal cancer; Glutathione (GSH); Glutathione S-transferase (GST); Malondialdehyde (MDA)