title: HIV-associated multicentric Castleman's disease.
abstract: Multicentric Castleman's disease (MCD) is a rare lymphoproliferative disorder. It is found with higher frequency in patients with HIV infection, with systemic symptoms and poor prognosis. We present the case of a 32-year old man with HIV disease, Kaposi's sarcoma, lymphadenopathy, fever and hemolytic anemia. A diagnosis of Castleman's disease is confirmed through biopsy and treatment is often based only on published case reports. Systemic treatments for MCD have included chemotherapy, anti-herpes virus, highly active antiretroviral therapy and, more recently, monoclonal antibodies against both IL6 and CD20.
authors.affiliation: Instituto Paulista de Cancerologia, ; Conjunto Hospitalar do Mandaqui, ; Instituto do Câncer Arnaldo Vieira de Carvalho, São Paulo, Brazil.
authors.forename: Fauzia de Fátima
authors.initials: Fde F
authors.lastname: Naime
authors.forename: Felipe
authors.initials: F
authors.lastname: Fakhouri
authors.forename: Carlos Saraiva
authors.initials: CS
authors.lastname: Martins
authors.forename: Wilson José
authors.initials: WJ
authors.lastname: Couto
keywords: Castleman's disease; HIV; Kaposi's sarcoma; human herpes virus-8; rituximab.