title: Effect of uridine on energy metabolism, LPO, and antioxidant system in the myocardium under conditions of acute coronary insufficiency.
abstract: Experiments on rats have shown that preventive treatment with uridine stabilizes energy metabolism in the heart under conditions of 60-min left coronary artery occlusion. The preparation also prevented antioxidant system dysfunction and LPO hyperactivation. 5-Hydroxydecanoate, a selective blocker of mitochondrial ATP-dependent K(+)-channels, abolished the protective effect of uridine, which attested to the involvement of these channels into mechanisms of the cardioprotective effect of the preparation. The elimination of intravenously administered uridine from the blood of animals with acute ischemia was accelerated in comparison with that in intact animals, which could suggest the participation of this nucleoside in the processes of activation of intracellular anti-ischemic defense mechanisms.
authors.affiliation: Department of Neuropharmacology, Institute of Experimental Medicine, NorthWestern Branch of the Russian Academy of Medical Sciences, St Petersburg, Russia.
authors.forename: I B
authors.initials: IB
authors.lastname: Krylova
authors.forename: V V
authors.initials: VV
authors.lastname: Bulion
authors.forename: E N
authors.initials: EN
authors.lastname: Selina
authors.forename: G D
authors.initials: GD
authors.lastname: Mironova
authors.forename: N S
authors.initials: NS
authors.lastname: Sapronov
mesh_terms: D000255:Adenosine Triphosphate / Q000378:metabolism; D000818:Animals; D043303:Aryldialkylphosphatase / Q000097:blood; D002851:Chromatography, High Pressure Liquid; D054059:Coronary Occlusion / Q000503:physiopathology*; D003331:Coronary Vessels / Q000601:surgery; D004734:Energy Metabolism / Q000187:drug effects*; D005978:Glutathione / Q000378:metabolism; D007275:Injections, Intravenous; D008026:Ligation; D008054:Lipid Peroxides / Q000378:metabolism; D008297:Male; D009206:Myocardium / Q000378:metabolism*; D010725:Phosphocreatine / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D018709:Statistics, Nonparametric; D013482:Superoxide Dismutase / Q000378:metabolism; D014529:Uridine / Q000008:administration & dosage / Q000097:blood / Q000494:pharmacology*
chemical_list: D008054:Lipid Peroxides; D010725:Phosphocreatine; D000255:Adenosine Triphosphate; D013482:Superoxide Dismutase; D043303:Aryldialkylphosphatase; D005978:Glutathione; D014529:Uridine