title: Total joint arthroplasty in human immunodeficiency virus positive patients.
abstract: Recent advances in the medical management of patients with human immunodeficiency virus (HIV) have led to improvement in their life expectancy. The growing numbers of HIV-positive patients are now living long enough to develop end-stage arthritis, as well as other long-term musculoskeletal complications of HIV infection and treatment. This has resulted in an increased demand for total joint arthroplasty among these individuals. However, the safety and outcomes of such procedures are frequently questioned in published reports. Although increased complication rates have often been reported, most studies have reported on joint arthroplasties in HIV patients with hemophilia. The most widely reported complications in both HIV-negative and positive hemophiliac patients are aseptic loosening and postoperative infection. A possible relationship between the rate of these complications and cluster of differentiation (CD4) lymphocyte count has also been proposed. In addition to hemophilia, other factors frequently comorbid with HIV infection, such as intravenous drug use, can further complicate the clinical outcomes of these individuals following total joint replacement procedures. Physicians treating HIV positive patients must remain aware of the risks and outcomes of total joint surgery in this group when counseling them on treatment options.
authors.affiliation: Department of Orthopaedic Surgery, New York University Hospital for Joint Diseases, New York, New York, USA.
authors.forename: Stephanie
authors.initials: S
authors.lastname: Swensen
authors.forename: Ran
authors.initials: R
authors.lastname: Schwarzkopf
mesh_terms: D000305:Adrenal Cortex Hormones / Q000009:adverse effects; D019380:Anti-HIV Agents / Q000009:adverse effects; D019643:Arthroplasty, Replacement / Q000009:adverse effects*; D015658:HIV Infections / Q000150:complications*; D006467:Hemophilia A / Q000150:complications; D006801:Humans; D010020:Osteonecrosis / Q000209:etiology / Q000601:surgery*; D011475:Prosthesis Failure / Q000209:etiology; D016896:Treatment Outcome
chemical_list: D000305:Adrenal Cortex Hormones; D019380:Anti-HIV Agents