title: Nordic walking decreased circulating chemerin and leptin concentrations in middle-aged men with impaired glucose regulation.
abstract: BACKGROUND
  Dysfunction of adipose tissue is one of the major factors leading to insulin resistance. Altered adipokine concentration is an early sign of adipose tissue dysfunction. The aim of this study was to assess the impact of exercise intervention on adipokine profile, glycemic control, and risk factors of the metabolic syndrome (MeS) in men with impaired glucose regulation (IGR).
  
  
  METHODS
  Overweight and obese men with IGR (n =144) aged 40-65 years were studied at baseline and at 12 weeks in a randomized controlled multicenter intervention study. BMI varied from 25.1 to 34.9. The subjects were randomized into one of three groups: 1) a control group (C; n =47), 2) a Nordic walking group (NW; n =48), or 3) a resistance training group (RT; n =49).
  
  
  RESULTS
  Leptin concentrations decreased in the NW group compared to both other groups. Both types of exercise intervention significantly decreased serum chemerin concentrations compared to the C group. In the NW group also body fat percentage, fatty liver index (FLI), and total and LDL cholesterol concentrations decreased compared to the RT group.
  
  
  CONCLUSIONS
  Nordic walking intervention seems to decrease chemerin and leptin levels, and subjects in this intervention group achieved the most beneficial effects on components of MeS.
authors.affiliation: Turku University of Applied Sciences, Turku, Finland. mika.venojarvi@uef.fi
authors.forename: Mika
authors.initials: M
authors.lastname: Venojärvi
authors.forename: Niko
authors.initials: N
authors.lastname: Wasenius
authors.forename: Sirpa
authors.initials: S
authors.lastname: Manderoos
authors.forename: Olli J
authors.initials: OJ
authors.lastname: Heinonen
authors.forename: Miika
authors.initials: M
authors.lastname: Hernelahti
authors.forename: Harri
authors.initials: H
authors.lastname: Lindholm
authors.forename: Jukka
authors.initials: J
authors.lastname: Surakka
authors.forename: Jaana
authors.initials: J
authors.lastname: Lindström
authors.forename: Sirkka
authors.initials: S
authors.lastname: Aunola
authors.forename: Mustafa
authors.initials: M
authors.lastname: Atalay
authors.forename: Johan G
authors.initials: JG
authors.lastname: Eriksson
mesh_terms: D000328:Adult; D000368:Aged; D001786:Blood Glucose / Q000378:metabolism*; D018925:Chemokines / Q000097:blood*; D015444:Exercise / Q000502:physiology*; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins; D020738:Leptin / Q000097:blood*; D008297:Male; D024821:Metabolic Syndrome / Q000097:blood* / Q000378:metabolism; D008875:Middle Aged; D009765:Obesity / Q000097:blood* / Q000378:metabolism; D050177:Overweight / Q000097:blood* / Q000378:metabolism; D012307:Risk Factors; D016138:Walking / Q000502:physiology*
chemical_list: D001786:Blood Glucose; D018925:Chemokines; D036341:Intercellular Signaling Peptides and Proteins; D020738:Leptin; C478630:RARRES2 protein, human