title: Lipid peroxidation and the levels of antioxidant enzymes in coronary artery disease.
abstract: Coronary Artery Disease is the major cause of mortality and morbidity worldwide. Traditional risk factors account for only half of the morbidity and mortality from coronary artery disease. There is substantial evidence that oxidative stress plays the major role in the atherosclerotic process. The present study was undertaken to evaluate the level of lipid peroxidation (by measuring malondialdehyde) and antioxidant enzymes (ceruloplasmin, glutathione, superoxide dismutase) in coronary artery disease. Serum malondialdehyde levels and serum ceruloplasmin levels were significantly raised in all the subgroups of study group as compared to control group (p<0.001). Whole blood glutathione levels and hemolysate superoxide dismutase activity was significantly decreased in all the subgroups of study group as compared to control group (p<0.001). Above results suggests that the patients of coronary artery disease show increased oxidative stress and decreased levels of antioxidant enzymes. So it is recommended that the management protocol for coronary artery disease patients should include antioxidant supplementation along with simultaneous lowering of lipid peroxidation.
authors.affiliation: Department of Biochemistry, Govt. Medical College, Patiala, India.
authors.forename: K
authors.initials: K
authors.lastname: Kaur
authors.forename: G
authors.initials: G
authors.lastname: Bedi
authors.forename: M
authors.initials: M
authors.lastname: Kaur
authors.forename: Anil
authors.initials: A
authors.lastname: Vij
authors.forename: Inderpreet
authors.initials: I
authors.lastname: Kaur
keywords: Antioxidants; Ceruloplasmin; Coronary artery disease; Lipid peroxidation