title: Sézary syndrome, Kaposi sarcoma and generalized dermatophytosis 15 years after sulfur mustard gas exposure.
abstract: BACKGROUND
  The relationship between compromised immune system and the development of malignancy, generalized dermatitis, and infection after sulfur mustard gas exposure has been established.
  
  
  METHODS
  We introduce a 58-year-old man with an abrupt, de novo and erythrodermic eruption in 2002 that was previously exposed to sulfur mustard during the Iran - Iraq war in 1987. Six weeks after the onset of diffuse eruption, he developed papules on the glans penis and generalized dermatophytosis. A biopsy of his eruption was consistent with cutaneous T-cell lymphoma/Sézary syndrome. A complete blood count demonstrated leukocytosis, eosinophilia and atypical lymphocytosis. Subsequently, Sézary syndrome was confirmed and T-cell count with increased CD4/CD8 in flow cytometry. The biopsy of his penile papules was consistent with Kaposi's sarcoma.
  
  
  CONCLUSIONS
  These findings suggest a causative relationship between sulfur mustard gas exposure, cutaneous T cell lymphoma and immune compromised state with opportunistic infections.
authors.affiliation: Chemical Injuries Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran  ; Skin Research Center, Mazandaran University of Medical Sciences, Sari, Iran  ; Tehran University of Medical Sciences, Tehran, Iran.
authors.forename: Seyed Naser
authors.initials: SN
authors.lastname: Emadi
authors.forename: Farhang
authors.initials: F
authors.lastname: Babamahmoodi
authors.forename: Zohreh
authors.initials: Z
authors.lastname: Poursaleh
authors.forename: Seyede Somaye
authors.initials: SS
authors.lastname: Sayad-Noori
authors.forename: Mohammad Reza
authors.initials: MR
authors.lastname: Soroush
authors.forename: Ali Reza
authors.initials: AR
authors.lastname: Maleki
authors.forename: Morteza
authors.initials: M
authors.lastname: Izadi
authors.forename: Mohammad Reza
authors.initials: MR
authors.lastname: Khodaei-Ardakan
authors.forename: Seyed Emad
authors.initials: SE
authors.lastname: Emadi
keywords: Kaposi's sarcoma; Sezary syndrome; cutaneous T-cell lymphoma; genital; genotoxins; war