title: XRCC1 Arg399Gln gene polymorphism and hepatocellular carcinoma risk in the Chinese Han population: a meta-analysis.
abstract: OBJECTIVE
  Numerous studies have evaluated the association between XRCC1 Arg399Gln gene polymorphism and hepatocellular carcinoma risk in the Chinese Han population. However, the results have been inconsistent. We therefore here examined whether the XRCC1 Arg399Gln gene polymorphism confers hepatocellular carcinoma risk by conducting a meta-analysis.
  
  
  METHODS
  PubMed, Google scholar and China National Knowledge Infrastructure databases were searched for eligible articles in English and Chinese that were published before April 2012.
  
  
  RESULTS
  6 studies involving 1,246 patients with hepatocellular carcinoma and 1,953 controls were included. The association between XRCC1 Arg399Gln gene polymorphism and hepatocellular carcinoma in the Chinese Han population was significant under GG vs AA (OR = 1.48, 95% CI = 1.13 to 1.94). Limiting the analysis to the studies with controls in the Hardy-Weinberg equilibrium, the results were persistent and robust.
  
  
  CONCLUSIONS
  In the Chinese Han population, the XRCC1 Arg399Gln gene polymorphism is associated with an increased hepatocellular carcinoma risk.
authors.affiliation: Institute of Hepatobiliary and Gastrointestinal Disease, Erpao General Hospital, Xicheng, Beijing, China.
authors.forename: Wei-Hong
authors.initials: WH
authors.lastname: Duan
authors.forename: Zhen-Yu
authors.initials: ZY
authors.lastname: Zhu
authors.forename: Jun-Gui
authors.initials: JG
authors.lastname: Liu
authors.forename: Mao-Sheng
authors.initials: MS
authors.lastname: Dong
authors.forename: Jun-Zhou
authors.initials: JZ
authors.lastname: Chen
authors.forename: Quan-Dda
authors.initials: QD
authors.lastname: Liu
authors.forename: Yu
authors.initials: Y
authors.lastname: Xie
authors.forename: Ti-Ye
authors.initials: TY
authors.lastname: Sun
authors.forename: Ze-Feng
authors.initials: ZF
authors.lastname: Gao
authors.forename: Ning-Xin
authors.initials: NX
authors.lastname: Zhou
mesh_terms: D044466:Asian People / Q000235:genetics*; D006528:Carcinoma, Hepatocellular / Q000453:epidemiology / Q000209:etiology*; D016022:Case-Control Studies; D002681:China / Q000453:epidemiology; D004268:DNA-Binding Proteins / Q000235:genetics*; D020022:Genetic Predisposition to Disease; D006801:Humans; D008113:Liver Neoplasms / Q000453:epidemiology / Q000209:etiology*; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D012307:Risk Factors; D000076105:X-ray Repair Cross Complementing Protein 1
chemical_list: D004268:DNA-Binding Proteins; D000076105:X-ray Repair Cross Complementing Protein 1; C000619371:XRCC1 protein, human