title: The efficacy of Cutanplast nasal packing after endoscopic sinus surgery: a prospective, randomized, controlled trial.
abstract: OBJECTIVE
  Absorbable packing materials are commonly used after endoscopic sinus surgery (ESS). Cutanplast is a novel gelatin sponge with a powerful hemostatic effect that is rapidly absorbed. The purpose of this study was to investigate the efficacy of Cutanplast in patients following ESS.
  
  
  METHODS
  A multicenter, prospective, randomized, double-blind, paired, controlled trial.
  
  
  METHODS
  One hundred adult patients with chronic sinusitis requiring the same extent of ESS were included. Patients were excluded if they were undergoing septoplasty, turbinate surgery, revision surgery, and taking anticoagulants. Following surgery, one nasal cavity was packed with Cutanplast and the other one with Merocel. Hemostatic properties, patient discomfort while the packing was in situ, patient pain on removal, degree of bleeding on removal, time required to control bleeding after removal, the cost of the pack, and postoperative wound healing were evaluated.
  
  
  RESULTS
  Both packs were effective at preventing postoperative hemorrhage. However, Cutanplast was significantly more comfortable while in situ (mean difference, 0.90; 95% confidence interval [CI], 0.75-1.25) and less painful on removal of the pack (mean difference, 1.36; 95% CI, 0.85-1.71). The Merocel pack was associated with significantly more bleeding on removal (mean difference, 1.23; 95% CI, 0.61-2.29), therefore much time was needed to control hemorrhage (mean difference, 1.05; 95% CI, 0.31-1.45). There was no significant difference in the cost of the pack used and outcome measure of wound healing.
  
  
  CONCLUSIONS
  Cutanplast nasal pack results in significantly less pain and less bleeding compared to Merocel pack.
authors.affiliation: Department of Otorhinolaryngology and Biomedical Research Institute, Pusan National University School of Medicine, Busan, South Korea.
authors.forename: Kyu-Sup
authors.initials: KS
authors.lastname: Cho
authors.forename: Seung-Kuk
authors.initials: SK
authors.lastname: Shin
authors.forename: Jung-Hoon
authors.initials: JH
authors.lastname: Lee
authors.forename: Joo-Yeon
authors.initials: JY
authors.lastname: Kim
authors.forename: Soo-Kweon
authors.initials: SK
authors.lastname: Koo
authors.forename: Yong-Wan
authors.initials: YW
authors.lastname: Kim
authors.forename: Min-Jung
authors.initials: MJ
authors.lastname: Kim
authors.forename: Hwan-Jung
authors.initials: HJ
authors.lastname: Roh
mesh_terms: D000328:Adult; D001672:Biocompatible Materials; D002908:Chronic Disease; D004724:Endoscopy; D005781:Gelatin Sponge, Absorbable; D006490:Hemostatics / Q000008:administration & dosage*; D006801:Humans; D013517:Otorhinolaryngologic Surgical Procedures / Q000379:methods; D011182:Postoperative Care / Q000379:methods*; D019106:Postoperative Hemorrhage / Q000517:prevention & control; D011446:Prospective Studies; D012220:Rhinitis / Q000601:surgery*; D012852:Sinusitis / Q000601:surgery*; D014945:Wound Healing
chemical_list: D001672:Biocompatible Materials; D006490:Hemostatics