title: Relapse of herpes encephalitis induced by temozolomide-based chemoradiation in a patient with malignant glioma.
abstract: The authors report on a case of concurrent herpes simplex encephalitis (HSE) and malignant glioma. The co-occurrence of HSE and malignant glioma is very rare, but it can occur during glioma treatment. Both radiotherapy and chemoradiation with temozolomide can induce viral reactivation, leading to HSE relapse. Careful observation for HSE is necessary when administering chemoradiation to patients with a history of HSE. Antiviral therapy for HSE must be initiated immediately, and the chemoradiation for glioma should be stopped; however, it is not clear what antitumor therapy is optimal when HSE co-occurs during the treatment of glioma.
authors.affiliation: Department of Neurological Surgery, Kagawa University Faculty of Medicine, Kagawa, Japan. neuron@med.kagawa-u.ac.jp
authors.forename: Masaki
authors.initials: M
authors.lastname: Okada
authors.forename: Keisuke
authors.initials: K
authors.lastname: Miyake
authors.forename: Aya
authors.initials: A
authors.lastname: Shinomiya
authors.forename: Nobuyuki
authors.initials: N
authors.lastname: Kawai
authors.forename: Takashi
authors.initials: T
authors.lastname: Tamiya
mesh_terms: D000328:Adult; D018906:Antineoplastic Agents, Alkylating / Q000009:adverse effects; D001932:Brain Neoplasms / Q000473:pathology / Q000628:therapy*; D059248:Chemoradiotherapy / Q000009:adverse effects*; D003606:Dacarbazine / Q000009:adverse effects / Q000031:analogs & derivatives; D020803:Encephalitis, Herpes Simplex / Q000473:pathology / Q000821:virology*; D005910:Glioma / Q000473:pathology / Q000628:therapy*; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D012008:Recurrence; D000077204:Temozolomide; D014775:Virus Activation / Q000187:drug effects* / Q000528:radiation effects*
chemical_list: D018906:Antineoplastic Agents, Alkylating; D003606:Dacarbazine; D000077204:Temozolomide