title: Gastroesophageal reflux disease and antireflux surgery-what is the proper preoperative work-up?
abstract: BACKGROUND
  Many surgeons feel comfortable performing antireflux surgery (ARS) on the basis of symptomatic evaluation, endoscopy, and barium esophagography. While esophageal manometry is often obtained to assess esophageal peristalsis, pH monitoring is rarely considered necessary to confirm the diagnosis of gastroesophageal reflux disease (GERD).
  
  
  OBJECTIVE
  The aim of this study was to analyze the sensitivity and specificity of symptoms, endoscopy, barium esophagography, and manometry as compared to pH monitoring in the preoperative evaluation of patients for ARS.
  
  
  METHODS
  One hundred and thirty-eight patients were referred for ARS with a diagnosis of GERD based on symptoms, endoscopy, and/or barium esophagography. Barium esophagography, esophageal manometry, and ambulatory 24-h pH monitoring were performed preoperatively in every patient.
  
  
  RESULTS
  Four patients were found to have achalasia and were excluded from the analysis. Based on the presence or absence of gastroesophageal reflux on pH monitoring, the remaining 134 patients were divided into two groups: GERD+ (n = 78, 58 %) and GERD- (n = 56, 42 %). The groups were compared with respect to the incidence of symptoms, presence of reflux and hiatal hernia on esophagogram, endoscopic findings, and esophageal motility. There was no difference in the incidence of symptoms between the two groups. Within the GERD+ group, 37 patients (47 %) had reflux at the esophagogram and 41 (53 %) had no reflux. Among the GERD- patients, 17 (30 %) had reflux and 39 (70 %) had no reflux. A hiatal hernia was present in 40 and 32 % of patients, respectively. Esophagitis was found at endoscopy in 16 % of GERD+ patients and in 20 % of GERD- patients. Esophageal manometry showed no difference in the pressure of the lower esophageal sphincter or quality of peristalsis between the two groups.
  
  
  CONCLUSIONS
  The results of this study showed that (a) symptoms were unreliable in diagnosing GERD, (b) the presence of reflux or hiatal hernia on esophagogram did not correlate with reflux on pH monitoring, (c) esophagitis on endoscopy had low sensitivity and specificity, and (d) manometry was mostly useful for positioning the pH probe and rule out achalasia. Ambulatory 24-h pH monitoring should be routinely performed in the preoperative work-up of patients suspected of having GERD in order to avoid unnecessary ARS.
authors.affiliation: Department of Surgery, University of Chicago Pritzker School of Medicine, 5841 S. Maryland Ave., MC 5095, Chicago, IL 60637, USA.
authors.forename: Brian
authors.initials: B
authors.lastname: Bello
authors.forename: Marco
authors.initials: M
authors.lastname: Zoccali
authors.forename: Roberto
authors.initials: R
authors.lastname: Gullo
authors.forename: Marco E
authors.initials: ME
authors.lastname: Allaix
authors.forename: Fernando A
authors.initials: FA
authors.lastname: Herbella
authors.forename: Arunas
authors.initials: A
authors.lastname: Gasparaitis
authors.forename: Marco G
authors.initials: MG
authors.lastname: Patti
mesh_terms: D001464:Barium; D003287:Contrast Media; D003371:Cough / Q000209:etiology; D003680:Deglutition Disorders / Q000209:etiology; D050782:Esophageal pH Monitoring; D004942:Esophagitis, Peptic / Q000175:diagnosis / Q000209:etiology; D004945:Esophagoscopy; D005260:Female; D005500:Follow-Up Studies; D018662:Fundoplication / Q000379:methods; D005764:Gastroesophageal Reflux / Q000150:complications / Q000175:diagnosis* / Q000601:surgery; D006356:Heartburn / Q000209:etiology; D006551:Hernia, Hiatal / Q000150:complications / Q000175:diagnosis; D006685:Hoarseness / Q000209:etiology; D006801:Humans; D010535:Laparoscopy; D008297:Male; D008365:Manometry; D008875:Middle Aged; D011300:Preoperative Care / Q000379:methods*; D012680:Sensitivity and Specificity
chemical_list: D003287:Contrast Media; D001464:Barium