title: Histamine H3 receptor antagonists/inverse agonists on cognitive and motor processes: relevance to Alzheimer's disease, ADHD, schizophrenia, and drug abuse.
abstract: Histamine H3 receptor (H3R) antagonists/inverse agonists possess potential to treat diverse disease states of the central nervous system (CNS). Cognitive dysfunction and motor impairments are the hallmark of multifarious neurodegenerative and/or psychiatric disorders. This review presents the various neurobiological/neurochemical evidences available so far following H3R antagonists in the pathophysiology of Alzheimer's disease (AD), attention-deficit hyperactivity disorder (ADHD), schizophrenia, and drug abuse each of which is accompanied by deficits of some aspects of cognitive and/or motor functions. Whether the H3R inverse agonism modulates the neurochemical basis underlying the disease condition or affects only the cognitive/motor component of the disease process is discussed with the aim to provide a rationale for their use in diverse disease states that are interlinked and are accompanied by some common motor, cognitive and attentional deficits.
authors.affiliation: Faculty of Pharmacy, Department of Pharmacology, Jamia Hamdard (Hamdard University) New Delhi, India.
authors.forename: Divya
authors.initials: D
authors.lastname: Vohora
authors.forename: Malay
authors.initials: M
authors.lastname: Bhowmik
keywords: ADHD; Alzheimer's disease; drug abuse; histamine H3 receptor; schizophrenia