title: Free and protein-bound angiotensin II(1-7)in the regulation of drinking behavior and hemodynamics in rats.
abstract: We compared physiological activity of synthetic analogues of endogenous protein-peptide compounds, complexes of angiotensin II(1-7)with functionally different proteins (transport protein, serum albumin; and neurospecific Ca(2+)-binding protein, S100b). Physiological activity of angiotensin II(1-7)was shown to depend on the type of a carrier protein. Our results suggest that complexes of angiotensins with BSA and S100b are strong factors for the integration of central and peripheral functions at the homeostatic and behavioral level.
authors.affiliation: Laboratory for Physiology of Motivations, PK Anokhin Institute of Normal Physiology, Russian Academy of Medical Sciences, Moscow, Russia. lab_motiv@mail.ru
authors.forename: S M
authors.initials: SM
authors.lastname: Tolpygo
authors.forename: E I
authors.initials: EI
authors.lastname: Pevtsova
authors.forename: B B
authors.initials: BB
authors.lastname: Shoibonov
authors.forename: A V
authors.initials: AV
authors.lastname: Kotov
mesh_terms: D000803:Angiotensin I / Q000008:administration & dosage / Q000378:metabolism / Q000494:pharmacology*; D000818:Animals; D002352:Carrier Proteins / Q000378:metabolism; D004327:Drinking Behavior / Q000187:drug effects / Q000502:physiology*; D006439:Hemodynamics / Q000187:drug effects / Q000502:physiology*; D007274:Injections, Intraperitoneal; D008297:Male; D046912:Multiprotein Complexes / Q000008:administration & dosage* / Q000378:metabolism / Q000494:pharmacology*; D009414:Nerve Growth Factors / Q000378:metabolism; D010446:Peptide Fragments / Q000008:administration & dosage / Q000378:metabolism / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D012084:Renin-Angiotensin System / Q000187:drug effects / Q000502:physiology*; D064568:S100 Calcium Binding Protein beta Subunit; D009418:S100 Proteins / Q000378:metabolism; D012709:Serum Albumin / Q000378:metabolism
chemical_list: D002352:Carrier Proteins; D046912:Multiprotein Complexes; D009414:Nerve Growth Factors; D010446:Peptide Fragments; D064568:S100 Calcium Binding Protein beta Subunit; D009418:S100 Proteins; C579158:S100b protein, rat; D012709:Serum Albumin; D000803:Angiotensin I; C118790:angiotensin I (1-7)