title: Nanogels fabricated by lysozyme and sodium carboxymethyl cellulose for 5-fluorouracil controlled release.
abstract: Lysozyme (Ly) and sodium carboxymethyl cellulose (CMC) were used to fabricate nanogels by a convenient method without using any chemical treatment except simple heating to achieve the denaturation temperature of Ly. The prepared nanogels were characterized by dynamic laser scattering (DLS), rheological analysis, transmission electron microscopy (TEM), field emission scanning electron microscope (FE-SEM) and X-ray photoelectron spectroscopy (XPS). The nanogels are of spherical shape with average hydrodynamic diameter of 241 nm and the swelling ratio of nanogels is about 5. Then 5-fluorouracil was used as a model drug to investigate the entrapment efficiency and release ability in nanogels. It turned out to be that the release in simulated gastric fluid (SGF) was more slowly compared with that in simulated intestinal fluid (SIF), which could protect the 5-Fu in stomach and ensure it released in intestines.
authors.affiliation: Key Laboratory of Environment Correlative Dietology (Huazhong Agricultural University), Ministry of Education, China.
authors.forename: Kunkun
authors.initials: K
authors.lastname: Zhu
authors.forename: Ting
authors.initials: T
authors.lastname: Ye
authors.forename: Jinjin
authors.initials: J
authors.lastname: Liu
authors.forename: Zheng
authors.initials: Z
authors.lastname: Peng
authors.forename: Shasha
authors.initials: S
authors.lastname: Xu
authors.forename: Jieqiong
authors.initials: J
authors.lastname: Lei
authors.forename: Hongbing
authors.initials: H
authors.lastname: Deng
authors.forename: Bin
authors.initials: B
authors.lastname: Li
mesh_terms: D000964:Antimetabolites, Antineoplastic / Q000008:administration & dosage*; D002266:Carboxymethylcellulose Sodium / Q000737:chemistry*; D003692:Delayed-Action Preparations; D004337:Drug Carriers / Q000737:chemistry; D016503:Drug Delivery Systems; D005472:Fluorouracil / Q000008:administration & dosage*; D005750:Gastric Juice / Q000378:metabolism; D005782:Gels; D007419:Intestinal Secretions / Q000378:metabolism; D007834:Lasers; D008855:Microscopy, Electron, Scanning; D046529:Microscopy, Electron, Transmission; D009113:Muramidase / Q000737:chemistry*; D053758:Nanoparticles; D010316:Particle Size; D056951:Photoelectron Spectroscopy; D012212:Rheology; D012542:Scattering, Radiation; D013696:Temperature
chemical_list: D000964:Antimetabolites, Antineoplastic; D003692:Delayed-Action Preparations; D004337:Drug Carriers; D005782:Gels; D009113:Muramidase; D002266:Carboxymethylcellulose Sodium; D005472:Fluorouracil