title: PrP-associated resistance to scrapie in five highly infected goat herds.
abstract: The PrP gene polymorphisms at codons 142 (I/M), 154 (R/H), 211 (R/Q), 222 (Q/K) and 240 (S/P) and their association with susceptibility to classical scrapie infection were investigated in five French goat herds displaying a high disease prevalence (>10%). On the basis of PrP(Sc) detection in the central nervous system and in various lymphoid tissues, 301 of 1343 goats were found to be scrapie infected. The statistical analyses indicated that while P(240) mutation had no direct impact on scrapie infection risk, the H(154), Q(211) and K(222) mutations were associated with high resistance to scrapie. The M(142) mutated allele was associated with a limited protection level against the disease. These results further reinforce the view that, like in sheep, the control and eradication of classical scrapie through the selection of certain PrP alleles could be envisaged in commercial goat population.
authors.affiliation: INRA, UMR 1225, Interactions Hôtes Agents Pathogènes, Ecole Nationale Vétérinaire de Toulouse, 23 Chemin des Capelles, 31076 Toulouse Cedex, France.
authors.forename: Fabien
authors.initials: F
authors.lastname: Corbière
authors.affiliation: ANSES, Laboratoire d'Etudes et de Recherches Caprines, BP 3081, 79012 Niort Cedex, France.
authors.forename: Cécile
authors.initials: C
authors.lastname: Perrin-Chauvineau
authors.affiliation: INRA, UMR 1225, Interactions Hôtes Agents Pathogènes, Ecole Nationale Vétérinaire de Toulouse, 23 Chemin des Capelles, 31076 Toulouse Cedex, France.
authors.forename: Caroline
authors.initials: C
authors.lastname: Lacroux
authors.affiliation: INRA, UMR 1225, Interactions Hôtes Agents Pathogènes, Ecole Nationale Vétérinaire de Toulouse, 23 Chemin des Capelles, 31076 Toulouse Cedex, France.
authors.forename: Pierrette
authors.initials: P
authors.lastname: Costes
authors.affiliation: ANSES, Laboratoire d'Etudes et de Recherches Caprines, BP 3081, 79012 Niort Cedex, France.
authors.forename: Myriam
authors.initials: M
authors.lastname: Thomas
authors.affiliation: ANSES, Laboratoire d'Etudes et de Recherches Caprines, BP 3081, 79012 Niort Cedex, France.
authors.forename: Isabelle
authors.initials: I
authors.lastname: Brémaud
authors.affiliation: ANSES, Laboratoire d'Etudes et de Recherches Caprines, BP 3081, 79012 Niort Cedex, France.
authors.forename: Samuel
authors.initials: S
authors.lastname: Martin
authors.affiliation: INRA, UMR 1225, Interactions Hôtes Agents Pathogènes, Ecole Nationale Vétérinaire de Toulouse, 23 Chemin des Capelles, 31076 Toulouse Cedex, France.
authors.forename: Séverine
authors.initials: S
authors.lastname: Lugan
authors.affiliation: ANSES, Laboratoire d'Etudes et de Recherches Caprines, BP 3081, 79012 Niort Cedex, France.
authors.forename: Christophe
authors.initials: C
authors.lastname: Chartier
authors.affiliation: INRA, UMR 1225, Interactions Hôtes Agents Pathogènes, Ecole Nationale Vétérinaire de Toulouse, 23 Chemin des Capelles, 31076 Toulouse Cedex, France.
authors.forename: François
authors.initials: F
authors.lastname: Schelcher
authors.affiliation: INRA, UR 631, Station d'Amélioration Génétique des Animaux, BP 52627, 31326 Castanet-Tolosan Cedex, France.
authors.forename: Francis
authors.initials: F
authors.lastname: Barillet
authors.affiliation: INRA, UMR 1225, Interactions Hôtes Agents Pathogènes, Ecole Nationale Vétérinaire de Toulouse, 23 Chemin des Capelles, 31076 Toulouse Cedex, France.
authors.forename: Olivier
authors.initials: O
authors.lastname: Andreoletti
mesh_terms: D000483:Alleles; D000818:Animals; D002490:Central Nervous System / Q000276:immunology / Q000378:metabolism; D005602:France / Q000453:epidemiology; D020022:Genetic Predisposition to Disease; D015511:Goat Diseases / Q000453:epidemiology / Q000235:genetics* / Q000276:immunology; D006041:Goats; D008221:Lymphoid Tissue / Q000276:immunology / Q000378:metabolism; D009154:Mutation; D011110:Polymorphism, Genetic; D015995:Prevalence; D011328:Prions / Q000235:genetics*; D012608:Scrapie / Q000453:epidemiology / Q000235:genetics* / Q000276:immunology
chemical_list: D011328:Prions