title: Synthesis and biological activity of organoantimony(III)-containing heteropolytungstates.
abstract: Three discrete organoantimony(III)-containing heteropolytungstates [(PhSb(III))(4)(A-α-Ge(IV)W(9)O(34))(2)](12-) (1), [(PhSb(III))(4)(A-α-P(V)W(9)O(34))(2)](10-) (2), and [{2-(Me(2)NCH(2)C(6)H(4))Sb(III)}(3)(B-α-As(III)W(9)O(33))](3-) (3) have been synthesized in one-pot reactions in aqueous medium using the appropriate lacunary heteropolyanion precursor and organoantimony(III) source. Polyanions 1-3 were isolated as hydrated salts, (NH(4))(12)[(PhSb(III))(4)(A-α-Ge(IV)W(9)O(34))(2)]·20H(2)O (1a), Rb(9)Na[(PhSb(III))(4)(A-α-P(V)W(9)O(34))(2)]·20H(2)O (2a), and Rb(3)[{2-(Me(2)NCH(2)C(6)H(4))Sb(III)}(3)(B-α-As(III)W(9)O(33))]·7H(2)O (3a). The compounds 1a-3a were fully characterized in the solid state using infrared (IR) spectroscopy, single-crystal XRD, and thermogravimetric and elemental analyses. The stability of 1-3 in aqueous solution was confirmed by multinuclear NMR ((1)H, (13)C, (31)P, and (183)W) spectroscopy. Preliminary studies on the biological activity of 1-3 showed that all three compounds might act as potent antimicrobial agents.
authors.affiliation: School of Engineering and Science, Jacobs University, P.O. Box 750 561, 28725 Bremen, Germany.
authors.forename: Maria
authors.initials: M
authors.lastname: Barsukova-Stuckart
authors.forename: Luis F
authors.initials: LF
authors.lastname: Piedra-Garza
authors.forename: Bimersha
authors.initials: B
authors.lastname: Gautam
authors.forename: Gabriela
authors.initials: G
authors.lastname: Alfaro-Espinoza
authors.forename: Natalya V
authors.initials: NV
authors.lastname: Izarova
authors.forename: Abhishek
authors.initials: A
authors.lastname: Banerjee
authors.forename: Bassem S
authors.initials: BS
authors.lastname: Bassil
authors.forename: Matthias S
authors.initials: MS
authors.lastname: Ullrich
authors.forename: Hans J
authors.initials: HJ
authors.lastname: Breunig
authors.forename: Cristian
authors.initials: C
authors.lastname: Silvestru
authors.forename: Ulrich
authors.initials: U
authors.lastname: Kortz
mesh_terms: D000900:Anti-Bacterial Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D000965:Antimony / Q000737:chemistry* / Q000494:pharmacology; D001412:Bacillus subtilis / Q000187:drug effects; D018360:Crystallography, X-Ray; D004926:Escherichia coli / Q000187:drug effects; D004927:Escherichia coli Infections / Q000188:drug therapy; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D008958:Models, Molecular; D009942:Organometallic Compounds / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D013055:Spectrophotometry, Infrared; D013818:Thermogravimetry; D017973:Tungsten Compounds / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology
chemical_list: D000900:Anti-Bacterial Agents; D009942:Organometallic Compounds; D017973:Tungsten Compounds; D000965:Antimony; C045951:tungstate