title: Preoperative serum levels of soluble endoglin for prediction of recurrence in stage III colorectal cancer patients.
abstract: BACKGROUND
  To evaluate the clinical usefulness of serum levels of soluble form of endoglin in stage III colorectal adenocarcinomas (CRC) patients for detection of recurrence.
  
  
  METHODS
  The case-control study consisted of 80 stage III CRC patients who underwent surgery with curative intent and 70 age-and sex-matched healthy volunteers. Serum levels of soluble form of endoglin (sol-end) were measured in both groups. Also, predictive factors of recurrence were evaluated using multivariate analyses.
  
  
  RESULTS
  Serum levels of sol-end in stage III CRC patients were significantly higher than those in controls. There was not a significant association between serum levels of sol-end and clinicopathological features in CRC patients. Multivariate regression analysis showed the LNR (hazard ratio, 2.54; 95% CI, 1.46-4.34; p < 0.001), to be significant independent factors to estimate local recurrence in stage III CRC patients.
  
  
  CONCLUSIONS
  Preoperative serum levels of sol-end do not seem useful as a marker for detection of recurrence in stage III CRC patients.
authors.affiliation: Turkiye Yuksek Ihtisas Education and Research Hospital, Department of Gastroenterologic Surgery, Ankara, Turkey.
authors.forename: Ismail
authors.initials: I
authors.lastname: Gomceli
authors.forename: Mesut
authors.initials: M
authors.lastname: Tez
authors.forename: Erdal B
authors.initials: EB
authors.lastname: Bostanci
authors.forename: Nesrin
authors.initials: N
authors.lastname: Turhan
authors.forename: Ahu S
authors.initials: AS
authors.lastname: Kemik
authors.forename: Musa
authors.initials: M
authors.lastname: Akoglu
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015703:Antigens, CD / Q000097:blood*; D014408:Biomarkers, Tumor / Q000097:blood*; D015179:Colorectal Neoplasms / Q000097:blood* / Q000098:blood supply / Q000473:pathology / Q000601:surgery; D000071063:Endoglin; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009389:Neovascularization, Pathologic / Q000175:diagnosis; D011379:Prognosis; D011956:Receptors, Cell Surface / Q000097:blood*; D012008:Recurrence
chemical_list: D015703:Antigens, CD; D014408:Biomarkers, Tumor; C064206:ENG protein, human; D000071063:Endoglin; D011956:Receptors, Cell Surface