title: Effects of peripheral μ, δ, and Κ-opioid receptor agonists on the levels of anxiety and motor activity of rats.
abstract: The effects of intragastric administration of μ-, δ, and Κ-opioid receptor agonists DAMGO, DADLE, and ICI 204,448, respectively, on the anxiety and motor activity of rats in an elevated plus-maze were studied. Peripheral administration of ICI 204,448 produced an anxiolytic effect, but had no effect on motor activity of rats. DAMGO and DADLE reduced motor activity; DADLE also increased anxiety. The data on the opposite effects of ICI 204,448 and DADLE on anxiety confirmed our previous hypothesis on the interactions between the central and peripheral components of the endogenous opioid system.
authors.affiliation: PK Anokhin Institute of Physiology, Russian Academy of Medical Sciences, Moscow, Russia.
authors.forename: E V
authors.initials: EV
authors.lastname: Alexeeva
authors.forename: G A
authors.initials: GA
authors.lastname: Nazarova
authors.forename: S K
authors.initials: SK
authors.lastname: Sudakov
mesh_terms: D000818:Animals; D001007:Anxiety / Q000188:drug therapy*; D020875:Enkephalin, Ala(2)-MePhe(4)-Gly(5)- / Q000494:pharmacology*; D016308:Enkephalin, Leucine-2-Alanine / Q000494:pharmacology*; D008297:Male; D018782:Maze Learning / Q000187:drug effects; D009043:Motor Activity / Q000187:drug effects*; D011759:Pyrrolidines / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D011957:Receptors, Opioid / Q000819:agonists*; D018709:Statistics, Nonparametric
chemical_list: D011759:Pyrrolidines; D011957:Receptors, Opioid; D020875:Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; C060223:ICI 204448; D016308:Enkephalin, Leucine-2-Alanine