title: Highlights from the International Transporter Consortium second workshop.
abstract: The Second International Transporter Consortium (ITC) Workshop was held with the purpose of expanding on previous white-paper recommendations, discussing recent regulatory draft guidance documents on transporter-drug interactions, and highlighting transporter-related challenges in drug development. Specific goals were to discuss additional clinically relevant transporters (MATEs, MRP2, BSEP) and best-practice methodologies and to re-evaluate ITC decision trees based on actual case studies. The outcome of the workshop will be a series of white papers targeted for publication in 2013.
authors.affiliation: Drug Disposition, Lilly Research Laboratories, Indianapolis, Indiana, USA. m_zamek-gliszczynski@lilly.com
authors.forename: M J
authors.initials: MJ
authors.lastname: Zamek-Gliszczynski
authors.forename: K A
authors.initials: KA
authors.lastname: Hoffmaster
authors.forename: D J
authors.initials: DJ
authors.lastname: Tweedie
authors.forename: K M
authors.initials: KM
authors.lastname: Giacomini
authors.forename: K M
authors.initials: KM
authors.lastname: Hillgren
mesh_terms: D003299:Cooperative Behavior; D003663:Decision Trees; D015195:Drug Design; D004347:Drug Interactions; D006801:Humans; D038622:Internationality; D026901:Membrane Transport Proteins / Q000378:metabolism*; D004364:Pharmaceutical Preparations / Q000378:metabolism*
chemical_list: D026901:Membrane Transport Proteins; D004364:Pharmaceutical Preparations