title: Cutaneous nodules as a diagnostic clue in multiple myeloma.
abstract: Cutaneous plasmacytomas are monoclonal proliferations of plasma cells which can be classified into primary (with no other concomitant bony or extramedullary disease) or secondary (generally associated with multiple myeloma (MM), extramedullary plasmacytoma, or plasma cell leukemia). Cutaneous plasmacytomas can appear in some patients with MM and, rarely, the skin lesions suppose the first clinical manifestation of the disease. Their development is considered as a poor prognostic sign, associated with a life expectancy of less than 12 months after diagnosis. An unusual case of MM is described, in which the histopathological study of a skin nodule provided invaluable information for diagnosis.
authors.affiliation: Department of Dermatology, Hospital Universitario Ramón y Cajal, Madrid, Spain. asun.ballester@gmail.com
authors.forename: María Asunción
authors.initials: MA
authors.lastname: Ballester-Martínez
authors.forename: Carmen
authors.initials: C
authors.lastname: González-García
authors.forename: Beatriz
authors.initials: B
authors.lastname: Fleta-Asín
authors.forename: Ana
authors.initials: A
authors.lastname: Burdaspal-Moratilla
authors.forename: Almudena
authors.initials: A
authors.lastname: Santón-Roldán
authors.forename: Natalia
authors.initials: N
authors.lastname: Jiménez-Gómez
authors.forename: Manuel María
authors.initials: MM
authors.lastname: Martín-González
authors.forename: Pedro Jaén
authors.initials: PJ
authors.lastname: Olasolo
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D014408:Biomarkers, Tumor / Q000032:analysis; D001706:Biopsy; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008875:Middle Aged; D009101:Multiple Myeloma / Q000737:chemistry / Q000188:drug therapy / Q000473:pathology*; D011237:Predictive Value of Tests; D012867:Skin / Q000737:chemistry / Q000473:pathology*; D012878:Skin Neoplasms / Q000737:chemistry / Q000188:drug therapy / Q000473:pathology*
chemical_list: D014408:Biomarkers, Tumor