title: Biotin-functionalized semiconducting polymer in an organic field effect transistor and application as a biosensor.
abstract: This report presents biotin-functionalized semiconducting polymers that are based on fluorene and bithiophene co-polymers (F8T2). Also presented is the application of these polymers to an organic thin film transistor used as a biosensor. The side chains of fluorene were partially biotinylated after the esterification of the biotin with corresponding alcohol-groups at the side chain in F8T2. Their properties as an organic semiconductor were tested using an organic thin film transistor (OTFT) and were found to show typical p-type semiconductor curves. The functionality of this biosensor in the sensing of biologically active molecules such as avidin in comparison with bovine serum albumin (BSA) was established through a selective decrease in the conductivity of the transistor, as measured with a device that was developed by the authors. Changes to the optical properties of this polymer were also measured through the change in the color of the UV-fluorescence before and after a reaction with avidin or BSA.
authors.affiliation: Electronics and Telecommunications Research Institute (ETRI), 218 Gajeongno, Yuseong-Gu, Daejeon 305-700, Korea. zinsig.kim@gmail.com
authors.forename: Zin-Sig
authors.initials: ZS
authors.lastname: Kim
authors.forename: Sang Chul
authors.initials: SC
authors.lastname: Lim
authors.forename: Seong Hyun
authors.initials: SH
authors.lastname: Kim
authors.forename: Yong Suk
authors.initials: YS
authors.lastname: Yang
authors.forename: Do-Hoon
authors.initials: DH
authors.lastname: Hwang
mesh_terms: D000818:Animals; D001360:Avidin / Q000032:analysis / Q000737:chemistry / Q000378:metabolism; D015374:Biosensing Techniques / Q000295:instrumentation* / Q000379:methods; D001710:Biotin / Q000737:chemistry* / Q000378:metabolism; D002417:Cattle; D005461:Fluorine / Q000737:chemistry; D011108:Polymers / Q000737:chemistry*; D012666:Semiconductors / Q000295:instrumentation*; D012710:Serum Albumin, Bovine / Q000737:chemistry / Q000378:metabolism; D013050:Spectrometry, Fluorescence / Q000295:instrumentation / Q000379:methods
chemical_list: D011108:Polymers; D001360:Avidin; D012710:Serum Albumin, Bovine; D005461:Fluorine; D001710:Biotin
keywords: F8T2; OTFT; avidin; biosensor; biotin; fluorescence; organic semiconductor