title: Proportion of multidrug-resistant tuberculosis in human immunodeficiency virus/mycobacterium tuberculosis co-infected patients in Korea.
abstract: Much controversy surrounds the issue of whether HIV infection is a risk factor for developing multidrug-resistant tuberculosis (MDR-TB). In this study, we evaluated the prevalence of and risk factors for MDR-TB in HIV-infected patients at the National Medical Center of Korea. We reviewed the medical records of HIV/TB co-infected patients from January 2005 to May 2011; the drug susceptibility profiles were available for 55 patients. Of these, 32.7% had MDR-TB, which was approximately 3.6 times higher than the prevalence among the general population. Additionally, there were more additional AIDS-defining clinical illnesses in the MDR-TB group than in the non-MDR-TB group (27.8% vs 5.4%, P = 0.032). These results suggest that HIV infection and HIV-related immunosuppresion may contribute to the development of MDR-TB.
authors.affiliation: Department of Internal Medicine, National Medical Center, Seoul, Korea.
authors.forename: Joon Sung
authors.initials: JS
authors.lastname: Joh
authors.forename: H Christian
authors.initials: HC
authors.lastname: Hong
authors.forename: In A
authors.initials: IA
authors.lastname: Jeong
authors.forename: Bum Sik
authors.initials: BS
authors.lastname: Chin
authors.forename: Hye Jin
authors.initials: HJ
authors.lastname: Yang
authors.forename: Hongjo
authors.initials: H
authors.lastname: Choi
authors.forename: Ji Hwan
authors.initials: JH
authors.lastname: Bang
mesh_terms: D000328:Adult; D000368:Aged; D060085:Coinfection; D005260:Female; D015658:HIV Infections / Q000150:complications* / Q000453:epidemiology* / Q000382:microbiology; D006801:Humans; D007165:Immunosuppression Therapy; D008297:Male; D008875:Middle Aged; D009169:Mycobacterium tuberculosis / Q000302:isolation & purification; D015995:Prevalence; D056910:Republic of Korea / Q000453:epidemiology; D012189:Retrospective Studies; D012307:Risk Factors; D018088:Tuberculosis, Multidrug-Resistant / Q000150:complications* / Q000453:epidemiology* / Q000382:microbiology
keywords: HIV; Multidrug-Resistant Tuberculosis; Tuberculosis