title: Serum thymidine kinase 1 levels correlates with FDG uptake and prognosis in patients with non small cell lung cancer.
abstract: BACKGROUND
  TK1 found to be elevated biomarker in many solid cancers.
  
  
  OBJECTIVE
  The study aimed to assess the prognostic significance of a serum TK1 in patients with metastatic NSCLC.
  
  
  METHODS
  The study included 48 consecutive patients, newly diagnosed with metastatic NSCLC, and 10 healthy volunteers. Serum TK1 activity determined by ELISA method.
  
  
  RESULTS
  Patients with a bTK1 level >156 Du L(-1) had significantly shorter survival. TK1 level showed a strong correlation with primary tumor SUV(max).
  
  
  CONCLUSIONS
  The magnitude of maximum fluorodeoxyglucose uptake in primary tumors and the serum TK1 level in patients with metastatic NSCLC were found to be independent prognostic predictors of overall survival.
authors.affiliation: Department of Medical Oncology, Marmara University Hospital, Istanbul, Turkey. taner.korkmaz@gmail.com
authors.forename: Taner
authors.initials: T
authors.lastname: Korkmaz
authors.forename: Selcuk
authors.initials: S
authors.lastname: Seber
authors.forename: Kerem
authors.initials: K
authors.lastname: Okutur
authors.forename: Gul
authors.initials: G
authors.lastname: Basaran
authors.forename: Fulden
authors.initials: F
authors.lastname: Yumuk
authors.forename: Faysal
authors.initials: F
authors.lastname: Dane
authors.forename: Tunc
authors.initials: T
authors.lastname: Ones
authors.forename: Ozge
authors.initials: O
authors.lastname: Polat
authors.forename: Ozlem Cakir
authors.initials: OC
authors.lastname: Madenci
authors.forename: Gokhan
authors.initials: G
authors.lastname: Demir
authors.forename: N Serdar
authors.initials: NS
authors.lastname: Turhal
mesh_terms: D000328:Adult; D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D014408:Biomarkers, Tumor / Q000097:blood*; D002289:Carcinoma, Non-Small-Cell Lung / Q000000981:diagnostic imaging* / Q000188:drug therapy / Q000401:mortality / Q000473:pathology*; D005260:Female; D019788:Fluorodeoxyglucose F18; D006801:Humans; D053208:Kaplan-Meier Estimate; D008175:Lung Neoplasms / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000401:mortality / Q000473:pathology; D008297:Male; D008875:Middle Aged; D064847:Multimodal Imaging; D009362:Neoplasm Metastasis / Q000503:physiopathology; D049268:Positron-Emission Tomography; D011379:Prognosis; D011446:Prospective Studies; D019275:Radiopharmaceuticals; D013937:Thymidine Kinase / Q000097:blood*; D014057:Tomography, X-Ray Computed
chemical_list: D014408:Biomarkers, Tumor; D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18; D013937:Thymidine Kinase; C092717:thymidine kinase 1