title: Gynecomastia caused by ethionamide.
abstract: A 43 year old male patient, known case of multidrug resistant tuberculosis, was prescribed antitubercular drugs: kanamycin, levofloxacin, ethionamide, terizidone, Para-Aminosalicylate Sodium (PAS), pyrazinamide and pyridoxine. After 4 months of treatment, the patient developed a lump in the right breast which was approximately around 3 × 3 cm in size, tender on palpation, and not fixed to the underlying tissues. Ultrasonography (USG) revealed a hypoechoic mass of size 2.5 × 0.92 × 2.6 cm in the right breast region behind the nipple without any infiltration to the deeper structures. Gynecomastia due to ethionamide was suspected and the patient was advised anti-inflammatory drugs for 5 days without any change in drug therapy. The pain subsided; however, the nodule remained. Treatment was continued without any change till the patient stopped using the drugs on his own and without doctor's consent. Within a week of stopping of treatment the nodule also disappeared.
authors.affiliation: Department of Pharmacology, Dr. RP Govt. Medical College, Kangra at Tanda, Himachal Pradesh, India.
authors.forename: Parveen K
authors.initials: PK
authors.lastname: Sharma
authors.forename: Rekha
authors.initials: R
authors.lastname: Bansal
mesh_terms: D000328:Adult; D000995:Antitubercular Agents / Q000009:adverse effects*; D005000:Ethionamide / Q000009:adverse effects*; D006177:Gynecomastia / Q000139:chemically induced* / Q000175:diagnosis*; D006801:Humans; D008297:Male; D018088:Tuberculosis, Multidrug-Resistant / Q000188:drug therapy / Q000473:pathology
chemical_list: D000995:Antitubercular Agents; D005000:Ethionamide
keywords: Adverse drug reaction; Ethionamide; Gynecomastia