title: Organocatalytic asymmetric cyanation of isatin derived N-Boc ketoimines.
abstract: We report the first catalytic asymmetric cyanation of N-Boc ketoimines, which enables highly enantioselective synthesis of oxindole based α-amino nitriles. An unprecedented tandem aza-Wittig/Strecker reaction is also developed, emerging as a promising strategy for the catalytic asymmetric cyanation of ketoimines formed in situ from achiral ketones.
authors.affiliation: Shanghai Key Laboratory of Green Chemistry and Chemical Processes, Department of Chemistry, East China Normal University, 3663 N. Zhongshan Road, Shanghai 200062, PR China.
authors.forename: Yun-Lin
authors.initials: YL
authors.lastname: Liu
authors.forename: Jian
authors.initials: J
authors.lastname: Zhou