title: Exploration of the association between quality of life, assessed by the EQ-5D and ICECAP-O, and falls risk, cognitive function and daily function, in older adults with mobility impairments.
abstract: BACKGROUND
  Our research sought to understand how falls risk, cognitive function, and daily function are associated with health related quality of life (using the EuroQol-5D) and quality of life (using the ICECAP-O) among older adults with mobility impairments.
  
  
  METHODS
  The EQ-5D and ICECAP-O were administered at 12 months post first clinic attendance at the Vancouver Falls Prevention Clinic. We report descriptive statistics for all baseline characteristics collected at first clinic visit and primary outcomes of interest. Using multivariate stepwise linear regression, we assessed the construct validity of the EQ-5D and ICECAP-O using three dependent measures that are recognized indicators of "impaired mobility" - physiological falls risk, general balance and mobility, and cognitive status among older adults.
  
  
  RESULTS
  We report data on 215 seniors who attended the Vancouver Falls Prevention Clinic and received their first clinic assessment. Patients had a mean age of 79.3 (6.2) years. After accounting for known covariates (i.e., age and sex), the ICECAP-O domains explained a greater amount of variation in each of the three dependent measures compared with the EQ-5D domains.
  
  
  CONCLUSIONS
  Both the EQ-5D and ICECAP-O demonstrate associations with falls risk and general balance and mobility; however, only the ICECAP-O was associated with cognitive status among older adults with mobility impairments.
  
  
  BACKGROUND
  ClinicalTrials.gov Identifier: NCT01022866.
authors.affiliation: Centre for Clinical Epidemiology and Evaluation, Vancouver Coastal Health Research Institute, The University of British Columbia, Research Pavilion, 7th floor, 828 West 10th Avenue, V5Z 1M9, Vancouver, BC, Canada. jennifer.davis@ubc.ca
authors.forename: Jennifer C
authors.initials: JC
authors.lastname: Davis
authors.forename: Stirling
authors.initials: S
authors.lastname: Bryan
authors.forename: Rob
authors.initials: R
authors.lastname: McLeod
authors.forename: Jessica
authors.initials: J
authors.lastname: Rogers
authors.forename: Karim
authors.initials: K
authors.lastname: Khan
authors.forename: Teresa
authors.initials: T
authors.lastname: Liu-Ambrose
mesh_terms: D000058:Accidental Falls / Q000517:prevention & control*; D000203:Activities of Daily Living / Q000523:psychology; D000368:Aged; D000369:Aged, 80 and over; D003071:Cognition / Q000502:physiology*; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D008297:Male; D051346:Mobility Limitation; D011788:Quality of Life / Q000523:psychology; D015203:Reproducibility of Results; D012307:Risk Factors; D011795:Surveys and Questionnaires / Q000592:standards*