title: A novel furanoeremophilane with an unusual oxygen bridge from Senecio nemorensis.
abstract: Two new furanoeremophilanes, 1α, 6α-epoxy-9-oxo-10β-hydroxyl-furanoeremophilane (1), and 9-oxo-1α, 6β, 10β-trihydroxy-furanoeremophilane (2) were isolated from Senecio nemorensis. Their structures were elucidated by spectroscopic methods and X-ray crystallography. This is the first report of the isolation of the C1-C6 oxygen bridge of furanoeremophilane. Their cytotoxic effects on BEL7402 and NF-KB cell lines were tested.
authors.affiliation: Nanjing Institute for Comprehensive Utilization of Wild Plant, Nanjing 210042, China; China Pharmaceutical University, Nanjing 210009, China.
authors.forename: Baojun
authors.initials: B
authors.lastname: Shi
authors.forename: Ji
authors.initials: J
authors.lastname: Shi
authors.forename: Hongfang
authors.initials: H
authors.lastname: Jiang
authors.forename: Guixin
authors.initials: G
authors.lastname: Chou
authors.forename: Zhengtao
authors.initials: Z
authors.lastname: Wang
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry* / Q000494:pharmacology*; D045744:Cell Line, Tumor; D006801:Humans; D008958:Models, Molecular; D015394:Molecular Structure; D010100:Oxygen / Q000737:chemistry*; D000081223:Polycyclic Sesquiterpenes; D012674:Senecio / Q000737:chemistry*; D012717:Sesquiterpenes / Q000737:chemistry* / Q000494:pharmacology*
chemical_list: C582244:1alpha,6alpha-epoxy-9-oxo-10beta-hydroxyl-furanoeremophilane; C582245:9-oxo-1alpha,6beta,10beta-trihydroxy-furanoeremophilane; D000972:Antineoplastic Agents, Phytogenic; D000081223:Polycyclic Sesquiterpenes; D012717:Sesquiterpenes; D010100:Oxygen