title: CMV and Immunosenescence: from basics to clinics.
abstract: Alone among herpesviruses, persistent Cytomegalovirus (CMV) markedly alters the numbers and proportions of peripheral immune cells in infected-vs-uninfected people. Because the rate of CMV infection increases with age in most countries, it has been suggested that it drives or at least exacerbates "immunosenescence". This contention remains controversial and was the primary subject of the Third International Workshop on CMV & Immunosenescence which was held in Cordoba, Spain, 15-16th March, 2012. Discussions focused on several main themes including the effects of CMV on adaptive immunity and immunosenescence, characterization of CMV-specific T cells, impact of CMV infection and ageing on innate immunity, and finally, most important, the clinical implications of immunosenescence and CMV infection. Here we summarize the major findings of this workshop.
authors.affiliation: Immunology Unit, Instituto Maimónides de Investigación Biomédica de Córdoba (IMIBIC)-Reina Sofia University Hospital-University of Cordoba, Cordoba, Spain. rsolana@uco.es.
authors.forename: Rafael
authors.initials: R
authors.lastname: Solana
authors.forename: Raquel
authors.initials: R
authors.lastname: Tarazona
authors.forename: Allison E
authors.initials: AE
authors.lastname: Aiello
authors.forename: Arne N
authors.initials: AN
authors.lastname: Akbar
authors.forename: Victor
authors.initials: V
authors.lastname: Appay
authors.forename: Mark
authors.initials: M
authors.lastname: Beswick
authors.forename: Jos A
authors.initials: JA
authors.lastname: Bosch
authors.forename: Carmen
authors.initials: C
authors.lastname: Campos
authors.forename: Sara
authors.initials: S
authors.lastname: Cantisán
authors.forename: Luka
authors.initials: L
authors.lastname: Cicin-Sain
authors.forename: Evelyna
authors.initials: E
authors.lastname: Derhovanessian
authors.forename: Sara
authors.initials: S
authors.lastname: Ferrando-Martínez
authors.forename: Daniela
authors.initials: D
authors.lastname: Frasca
authors.forename: Tamas
authors.initials: T
authors.lastname: Fulöp
authors.forename: Sheila
authors.initials: S
authors.lastname: Govind
authors.forename: Beatrix
authors.initials: B
authors.lastname: Grubeck-Loebenstein
authors.forename: Ann
authors.initials: A
authors.lastname: Hill
authors.forename: Mikko
authors.initials: M
authors.lastname: Hurme
authors.forename: Florian
authors.initials: F
authors.lastname: Kern
authors.forename: Anis
authors.initials: A
authors.lastname: Larbi
authors.forename: Miguel
authors.initials: M
authors.lastname: López-Botet
authors.forename: Andrea B
authors.initials: AB
authors.lastname: Maier
authors.forename: Janet E
authors.initials: JE
authors.lastname: McElhaney
authors.forename: Paul
authors.initials: P
authors.lastname: Moss
authors.forename: Elissaveta
authors.initials: E
authors.lastname: Naumova
authors.forename: Janko
authors.initials: J
authors.lastname: Nikolich-Zugich
authors.forename: Alejandra
authors.initials: A
authors.lastname: Pera
authors.forename: Jerrald L
authors.initials: JL
authors.lastname: Rector
authors.forename: Natalie
authors.initials: N
authors.lastname: Riddell
authors.forename: Beatriz
authors.initials: B
authors.lastname: Sanchez-Correa
authors.forename: Paolo
authors.initials: P
authors.lastname: Sansoni
authors.forename: Delphine
authors.initials: D
authors.lastname: Sauce
authors.forename: Rene
authors.initials: R
authors.lastname: van Lier
authors.forename: George C
authors.initials: GC
authors.lastname: Wang
authors.forename: Mark R
authors.initials: MR
authors.lastname: Wills
authors.forename: Maciej
authors.initials: M
authors.lastname: Zieliński
authors.forename: Graham
authors.initials: G
authors.lastname: Pawelec