title: A fluorescent probe for detection of histone deacetylase activity based on aggregation-induced emission.
abstract: A tetraphenylethylene-derivative fluorescent probe for the one-step detection of histone deacetylases (HDAC) was developed. The deacetylation of the probe triggers electrostatic interaction between the molecules and automatically leads to fluorescence enhancement based on aggregation-induced emission (AIE).
authors.affiliation: Graduate School of Engineering, Osaka University, Osaka 565-0871, Japan.
authors.forename: Koushik
authors.initials: K
authors.lastname: Dhara
authors.forename: Yuichiro
authors.initials: Y
authors.lastname: Hori
authors.forename: Reisuke
authors.initials: R
authors.lastname: Baba
authors.forename: Kazuya
authors.initials: K
authors.lastname: Kikuchi
mesh_terms: D057075:Enzyme Assays / Q000379:methods*; D005030:Ethylenes / Q000737:chemistry; D005456:Fluorescent Dyes / Q000737:chemistry*; D006655:Histone Deacetylases / Q000378:metabolism*; D013050:Spectrometry, Fluorescence
chemical_list: D005030:Ethylenes; D005456:Fluorescent Dyes; C036216:ethylene; D006655:Histone Deacetylases