title: The influence of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on hematological parameters during experimentally induced pleuritis in rats.
abstract: Proper functioning of homeostatic mechanisms is characteristic for every healthy organism and enables adapting to environmental changes. These complicated systematic reactions can neutralize the harmful stress factors leading to various inflammatory reactions. The aim of this study was to determine dynamic changes in the inflammatory reaction after single 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) administration of 5 μg/kg body weight into rats with experimentally induced pleuritis. These changes were observed by monitoring the hematological blood parameters during inflammation. The obtained results proved that dioxins contribute to various changes in the character of the inflammatory response. TCDD administration before pleuritis initiation caused an increase of lymphocytes and significant decrease of the number of neutrophils during inflammation. The current study proved that administration of low TCDD dose (seven times lower than used in other studies) can cause thymus, spleen, or lymphatic gland atrophy. This finding indicates the toxic influence of small TCDD dose especially on the immune system.
authors.affiliation: Department of Nervous System Diseases, The Faculty of Health Science, Wroclaw Medical University, Bartla 5, 51-618, Wroclaw, Poland.
authors.forename: Ireneusz
authors.initials: I
authors.lastname: Całkosiński
authors.forename: Joanna
authors.initials: J
authors.lastname: Rosińczuk-Tonderys
authors.forename: Justyna
authors.initials: J
authors.lastname: Bazan
authors.forename: Katarzyna
authors.initials: K
authors.lastname: Dzierzba
authors.forename: Monika
authors.initials: M
authors.lastname: Całkosińska
authors.forename: Jacek
authors.initials: J
authors.lastname: Majda
authors.forename: Maciej
authors.initials: M
authors.lastname: Dobrzyński
authors.forename: Agnieszka
authors.initials: A
authors.lastname: Bronowicka-Szydełko
mesh_terms: D000818:Animals; D001284:Atrophy / Q000139:chemically induced; D001491:Basophils / Q000187:drug effects; D001772:Blood Cell Count; D001792:Blood Platelets / Q000187:drug effects; D002351:Carrageenan; D004804:Eosinophils / Q000187:drug effects; D004912:Erythrocytes / Q000187:drug effects; D005260:Female; D006400:Hematocrit; D006454:Hemoglobins / Q000032:analysis; D007249:Inflammation / Q000139:chemically induced*; D018655:Lymphocyte Count; D008214:Lymphocytes / Q000187:drug effects; D009504:Neutrophils / Q000187:drug effects; D010976:Platelet Count; D010998:Pleurisy / Q000097:blood*; D000072317:Polychlorinated Dibenzodioxins / Q000008:administration & dosage / Q000633:toxicity*; D051381:Rats
chemical_list: D006454:Hemoglobins; D000072317:Polychlorinated Dibenzodioxins; D002351:Carrageenan