title: Association of the atherogenic index of plasma and oxidative stress status with weight gain during non-complicated pregnancy.
abstract: BACKGROUND
  Pregnancy is a stressful condition linked with altered lipid profile, increased oxidative stress and increased inflammation processes. The purpose of the present study was to determine the associations between those alterations with increased weight gain during pregnancy.
  
  
  METHODS
  The atherogenic index of plasma (AIP) and oxidative stress status parameters were determinated in 50 healthy and 172 pregnant women with non-complicated pregnancy. Pregnant women were divided in four groups according to body mass index (BMI) values (BMI quartiles).
  
  
  RESULTS
  Oxidative stress parameters were significantly lower in the control group compared with all the pregnant women quartiles. Unexpectedly, differences in oxidative stress parameters between BMI quartiles groups were not significant. The antioxidant defence parameters remained quite similar in the different BMI quartiles. Weight gain and paraoxonase-1 (PON1) activities were independently associated with increased AIP while weight gain and triglyceride concentration were found to be significant predictors of PON1 activities.
  
  
  CONCLUSIONS
  The results of our current study indicate the association of maternal weight gain during pregnancy and altered lipid profile, elevated oxidative stress and changed antioxidative capacity of PON1. Taken together all these facts indicate possible increased risk of cardiovascular disease (CVD) development in later life if the weight gain during pregnancy is excessive.
authors.affiliation: Faculty of Pharmacy, Department of Medical Biochemistry, University of Belgrade, Serbia. alex@pharmacy.bg.ac.rs
authors.forename: Aleksandra
authors.initials: A
authors.lastname: Stefanović
authors.forename: Jelena
authors.initials: J
authors.lastname: Kotur-Stevuljević
authors.forename: Ana
authors.initials: A
authors.lastname: Vujović
authors.forename: Slavica
authors.initials: S
authors.lastname: Spasić
authors.forename: Vesna
authors.initials: V
authors.lastname: Spasojević-Kalimanovska
authors.forename: Zorana
authors.initials: Z
authors.lastname: Jelic-Ivanović
authors.forename: Jelena
authors.initials: J
authors.lastname: Martinović
authors.forename: Daniela
authors.initials: D
authors.lastname: Ardalić
authors.forename: Vesna
authors.initials: V
authors.lastname: Mandić-Marković
authors.forename: Zeljko
authors.initials: Z
authors.lastname: Miković
authors.forename: Nikola
authors.initials: N
authors.lastname: Cerović
mesh_terms: D050197:Atherosclerosis / Q000097:blood* / Q000378:metabolism* / Q000503:physiopathology; D015992:Body Mass Index; D005260:Female; D006801:Humans; D008055:Lipids / Q000097:blood*; D018384:Oxidative Stress; D011247:Pregnancy; D012044:Regression Analysis; D015430:Weight Gain
chemical_list: D008055:Lipids