title: [Biomarkers of inflammation in patients with chronic heart failure and implanted devices for cardiac resynchronization therapy].
abstract: The aim of the study was to assess the relationship between N-terminal pro-brain natriuretic peptide (NT-proBNP) and inflammatory markers in patients with congestive heart failure (CHF) treated with cardiac resynchronization therapy (CRT). 97 patients (age 54.9+/-9.9 years; 87% men) with implanted CRT devices (median period after implantation 19.9+/-19.3 months) were enrolled. According to NT-proBNP level patients were divided into tertiles: first (n=36) - less than 848 pg/ml, second (n=29) - from 848 to 2936 pg/ml, and third (n=32) - more than 2936 pg/ml. We didnt find a relationship between inflammatory mediators, NT-probNP level and time after implantation. In the total group NT-proBNP significantly correlated with structural and functional parameters of the heart. In the first group in comparison with the third group levels of IL-6 were lower (pI-III=0.019) and levels of IL-l - higher (pI-III=0.006). IL-10, CRP, TNF- did not differ between groups. In the first group IL-l straightly correlated with IL-6, TNF- , IL-10 and left ventricular ejection fraction (LVEF), in the third group IL-6 straightly correlated with CRP, while correlation of IL-l with LVEF became negative. We suppose that in patients with mild HF IL-l can play an adaptive role. High levels of IL-6, CRP probably can be used as markers of CHF progression in patients treated with CRT.
authors.forename: V A
authors.initials: VA
authors.lastname: Kuznetsov
authors.forename: A M
authors.initials: AM
authors.lastname: Soldatova
authors.forename: T N
authors.initials: TN
authors.lastname: Enina
authors.forename: P V
authors.initials: PV
authors.lastname: Shebeko
authors.forename: A Iu
authors.initials: AIu
authors.lastname: Rychkov
authors.forename: N N
authors.initials: NN
authors.lastname: Mel'nikov
authors.forename: D A
authors.initials: DA
authors.lastname: Zateĭshchikov
mesh_terms: D015415:Biomarkers / Q000097:blood*; D058409:Cardiac Resynchronization Therapy Devices; D016207:Cytokines / Q000097:blood; D005260:Female; D005500:Follow-Up Studies; D006333:Heart Failure / Q000097:blood* / Q000503:physiopathology / Q000628:therapy; D006801:Humans; D007249:Inflammation / Q000097:blood*; D008297:Male; D008875:Middle Aged; D020097:Natriuretic Peptide, Brain / Q000097:blood; D010446:Peptide Fragments / Q000097:blood; D011379:Prognosis; D011498:Protein Precursors; D012189:Retrospective Studies; D012720:Severity of Illness Index; D016277:Ventricular Function, Left
chemical_list: D015415:Biomarkers; D016207:Cytokines; D010446:Peptide Fragments; D011498:Protein Precursors; C109794:pro-brain natriuretic peptide (1-76); D020097:Natriuretic Peptide, Brain