title: [Bacteriocidal activity of Streptomyces cultures].
abstract: Bacteriocidal activity of metabolites synthesized by 17 plasmid-containing cultures of Streptomyces has been studied. These cultures were isolated from soils of Ukraine with different anthropogenic contamination. The cultures, in their majority (85.3%), synthesized bioactive metabolites, which suppressed growth of microorganisms of different taxonomical groups, pathogenic for people, animals or plants. None of 17 Streptomyces cultures was able to suppress growth of yeasts or Escherichia coli. All 17 investigated cultures of Streptomyces were polyresistant to antibiotics, which were used in medicine and veterinary: makrolide, aminoglycoside, beta-lactam and other groups. Resistance of 8 cultures to the antibiotic thiostrepton, which was widely used in some branches of science, was found.
authors.forename: L V
authors.initials: LV
authors.lastname: Polishchuk
authors.forename: O I
authors.initials: OI
authors.lastname: Bambura
authors.forename: V V
authors.initials: VV
authors.lastname: Luk'ianchuk
mesh_terms: D000900:Anti-Bacterial Agents / Q000096:biosynthesis / Q000302:isolation & purification / Q000494:pharmacology*; D024901:Drug Resistance, Multiple, Bacterial / Q000502:physiology; D004926:Escherichia coli / Q000187:drug effects / Q000254:growth & development; D008826:Microbial Sensitivity Tests; D020102:Mycobacterium smegmatis / Q000187:drug effects / Q000254:growth & development; D010957:Plasmids; D012988:Soil Microbiology; D013302:Streptomyces / Q000187:drug effects / Q000235:genetics / Q000378:metabolism* / Q000472:pathogenicity; D013883:Thiostrepton / Q000494:pharmacology; D014455:Ukraine
chemical_list: D000900:Anti-Bacterial Agents; D013883:Thiostrepton