title: Rhodium catalyzed synthesis of isoindolinones via C-H activation of N-benzoylsulfonamides.
abstract: An efficient approach to a wide range of isoindolinones, including 3-monosubstituted and 3,3-disubstituted isoindolinones, from the annulation of N-benzoylsulfonamides with olefins and diazoacetate has been developed. The transformation is broadly compatible with both terminal and internal olefins. Moreover, diazoacetate is for the first time incorporated into an amide-directed C-H functionalization reaction. Specifically, the rhodium complex [{RhCl(2)Cp*}(2)] enables the in situ dimerization of diazoacetate in addition to its role in catalyzing C-H functionalization/cross-coupling.
authors.affiliation: Department of Biochemistry, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd., Dallas, Texas 75390-9038, USA.
authors.forename: Chen
authors.initials: C
authors.lastname: Zhu
authors.forename: John R
authors.initials: JR
authors.lastname: Falck