title: Nukuhivensiums, indolo[2,3-a]quinoliziniums from the Marquesan plant Rauvolfia nukuhivensis.
abstract: The first phytochemical inspection of the Marquesan endemic plant Rauvolfia nukuhivensis led to the isolation and structure characterization of two new indolo[2,3-a]quinolizinium derivatives named nukuhivensium and N₁₂-methyl-nukuhivensium. They feature an aromatic indolo[2,3-a]quinolizinium core, substituted at C-2 by a n-propyl group, which is unusual in this family of alkaloid derivatives. The structure elucidation was performed on the basis of NMR spectroscopy and especially by interpretation of 2D HMBC correlations. A biosynthetic pathway is proposed on the basis of known enzymatic transformations for this family of natural products. These compounds exhibited low antimicrobial activities.
authors.affiliation: EIMS Laboratory UMR 241 EIO, University of French Polynesia, 98702 Faa'a, Tahiti, French Polynesia.
authors.forename: Nicolas J
authors.initials: NJ
authors.lastname: Martin
authors.forename: Soizic
authors.initials: S
authors.lastname: Prado
authors.forename: Gael
authors.initials: G
authors.lastname: Lecellier
authors.forename: Olivier P
authors.initials: OP
authors.lastname: Thomas
authors.forename: Phila
authors.initials: P
authors.lastname: Raharivelomanana
mesh_terms: D000890:Anti-Infective Agents / Q000737:chemistry / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology; D011807:Quinolizines / Q000737:chemistry* / Q000494:pharmacology; D011926:Rauwolfia / Q000737:chemistry*
chemical_list: D000890:Anti-Infective Agents; D010936:Plant Extracts; D011807:Quinolizines