title: The role of innate immune signals in immunity to Brucella abortus.
abstract: Innate immunity serves as the first line of defense against infectious agents such as intracellular bacteria. The innate immune platform includes Toll-like receptors (TLRs), retinoid acid-inducible gene-I-like receptors and other cytosolic nucleic acid sensors, nucleotide-binding and oligomerization domain-like receptors, adaptors, kinases and other signaling molecules that are required to elicit effective responses against different pathogens. Our research group has been using the Gram-negative bacteria Brucella abortus as a model of pathogen. We have demonstrated that B. abortus triggers MAPK and NF-κB signaling pathways in macrophages in a MyD88 and IRAK-4-dependent manner. Furthermore, we claimed that so far TLR9 is the most important single TLR during Brucella infection. The identification of host receptors that recognize pathogen-derived nucleic acids has revealed an essential role for nucleic acid sensing in the triggering of immunity to intracellular pathogens. Besides TLRs, herein we describe recent advances in NOD1, NOD2, and type I IFN receptors in innate immune pathways during B. abortus infection.
authors.affiliation: Department of Biochemistry and Immunology, Institute of Biological Sciences, Federal University of Minas Gerais Belo Horizonte, MG, Brazil.
authors.forename: Marco Túlio R
authors.initials: MT
authors.lastname: Gomes
authors.forename: Priscila C
authors.initials: PC
authors.lastname: Campos
authors.forename: Leonardo A
authors.initials: LA
authors.lastname: de Almeida
authors.forename: Fernanda S
authors.initials: FS
authors.lastname: Oliveira
authors.forename: Miriam Maria S
authors.initials: MM
authors.lastname: Costa
authors.forename: Fernanda M
authors.initials: FM
authors.lastname: Marim
authors.forename: Guilherme S M
authors.initials: GS
authors.lastname: Pereira
authors.forename: Sergio C
authors.initials: SC
authors.lastname: Oliveira
mesh_terms: D000818:Animals; D002003:Brucella abortus / Q000276:immunology*; D002006:Brucellosis / Q000276:immunology*; D006801:Humans; D007113:Immunity, Innate; D053592:Interleukin-1 Receptor-Associated Kinases / Q000378:metabolism; D008264:Macrophages / Q000276:immunology / Q000382:microbiology; D053594:Myeloid Differentiation Factor 88 / Q000378:metabolism; D015398:Signal Transduction; D051217:Toll-Like Receptor 9 / Q000378:metabolism
chemical_list: D053594:Myeloid Differentiation Factor 88; D051217:Toll-Like Receptor 9; D053592:Interleukin-1 Receptor-Associated Kinases
keywords: Brucella abortus; NLR; TLR signaling; innate immunity; type I interferon