title: Two-step synthesis of 2,3-dihydropyrroles via a formal 5-endo cycloisomerization of Ugi 4-CR/propargyl adducts.
abstract: A practical two-step synthesis of 2,3-dihydropyrroles from Ugi 4-CR/propargyl adducts is presented. The protocol includes a base-mediated formation of an allenamide functional group and an in situ metal-free formal 5-endo cycloisomerization that occurs in a highly regioselective manner at the allenamide C-γ.
authors.affiliation: Instituto de Química, Universidad Nacional Autónoma de México, Circuito Exterior, Ciudad Universitaria, Coyoacán, México D.F. 04510, Mexico.
authors.forename: Luis A
authors.initials: LA
authors.lastname: Polindara-García
authors.forename: Luis D
authors.initials: LD
authors.lastname: Miranda
mesh_terms: D002384:Catalysis; D003500:Cyclization; D007536:Isomerism; D015394:Molecular Structure; D011758:Pyrroles / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D011758:Pyrroles