title: Synthesis of coumarins via Pd-catalyzed oxidative cyclocarbonylation of 2-vinylphenols.
abstract: Palladium-catalyzed oxidative cyclocarbonylation of 2-vinylphenols constitutes a simple, direct method for the synthesis of coumarins. The reaction conditions, employing low pressures of CO, and air or 1,4- benzoquinone as the oxidant, are attractive in terms of environmental considerations and operational simplicity. Coumarins with a variety of functional groups were prepared in yields up to 85%.
authors.affiliation: Centre for Catalysis Research and Innovation, Department of Chemistry, University of Ottawa, 10 Marie Curie, Ottawa, Ontario, Canada, K1N 6N5.
authors.forename: Jamie
authors.initials: J
authors.lastname: Ferguson
authors.forename: Fanlong
authors.initials: F
authors.lastname: Zeng
authors.forename: Howard
authors.initials: H
authors.lastname: Alper
mesh_terms: D002384:Catalysis; D020650:Combinatorial Chemistry Techniques; D003374:Coumarins / Q000138:chemical synthesis* / Q000737:chemistry; D003500:Cyclization; D015394:Molecular Structure; D010084:Oxidation-Reduction; D010165:Palladium / Q000737:chemistry*; D010636:Phenols / Q000737:chemistry*; D014753:Vinyl Compounds / Q000737:chemistry*
chemical_list: D003374:Coumarins; D010636:Phenols; D014753:Vinyl Compounds; D010165:Palladium