title: 3D numerical study of tumor microenvironmental flow in response to vascular-disrupting treatments.
abstract: The effects of vascular-disrupting treatments on normalization of tumor microvasculature and its microenvironmental flow were investigated, by mathematical modeling and numerical simulation of tumor vascular-disrupting and tumor haemodynamics. Four disrupting approaches were designed according to the abnormal characteristics of tumor microvasculature compared with the normal one. The results predict that the vascular-disrupting therapies could improve tumor microenvironment, eliminate drug barrier and inhibit metastasis of tumor cells to some extent. Disrupting certain types of vessels may get better effects. In this study, the flow condition on the networks with "vascular-disrupting according to flowrate" is the best comparing with the other three groups, and disrupting vessels of lower maturity could effectively enhance fluid transport across vasculature into interstitial space.
authors.affiliation: School of Naval Architecture, Ocean and Civil Engineering, MOE Key Laboratory of Hydrodynamics, Shanghai Jiao Tong University, Shanghai, China. jiewu82@sjtu.edu.cn
authors.forename: Jie
authors.initials: J
authors.lastname: Wu
authors.forename: Yan
authors.initials: Y
authors.lastname: Cai
authors.forename: Shixiong
authors.initials: S
authors.lastname: Xu
authors.forename: Quan
authors.initials: Q
authors.lastname: Longs
authors.forename: Zurong
authors.initials: Z
authors.lastname: Ding
authors.forename: Cheng
authors.initials: C
authors.lastname: Dong
mesh_terms: D020533:Angiogenesis Inhibitors / Q000494:pharmacology; D003198:Computer Simulation; D006801:Humans; D021621:Imaging, Three-Dimensional; D018810:Magnetic Resonance Angiography; D008833:Microcirculation; D008962:Models, Theoretical; D009369:Neoplasms / Q000098:blood supply; D009389:Neovascularization, Pathologic / Q000188:drug therapy; D059016:Tumor Microenvironment / Q000187:drug effects
chemical_list: D020533:Angiogenesis Inhibitors