title: Peripheral intrahepatic cholangiocarcinoma occurring in patients without cirrhosis or chronic bile duct diseases:  epidemiology and histopathology of distant nontumoral liver in 57 White patients.
abstract: OBJECTIVE
  Peripheral intrahepatic cholangiocarcinoma (ICC) occurring mainly in the absence of cirrhosis represents an increasing subgroup of primary liver tumors in Western countries. Histopathologic changes in the non-neoplastic liver in this context are not well characterized.
  
  
  METHODS
  We assessed the clinical characteristics and histopathologic changes in the distant nontumoral liver of 57 consecutive White patients (34 men, mean age 59 years) referred to one medical and one surgical liver institution over a 16-year period who developed a peripheral ICC in the absence of cirrhosis or bile duct disease.
  
  
  RESULTS
  High alcohol consumption was observed in 11 patients (20%), 38 patients (66%) had a BMI of 25 kg/m or more, 22 patients (40%) had diabetes, two patients had hepatitis B virus infection, two others had hepatitis C virus infection, three patients had genetic hemochromatosis, and two patients had cutaneous porphyria tarda. The distant nontumoral liver was normal in 10 patients (18%). The two main histopathologic changes observed were macrovesicular steatosis (>10% of hepatocytes) in 38 patients (66%), including 11 patients (19%) with steatohepatitis, and moderate or intense hepatocyte iron overload in 22 patients (38%).
  
  
  CONCLUSIONS
  This study shows a high prevalence of macrovesicular steatosis associated or not with steatohepatitis and iron overload in patients who develop peripheral ICC in the absence of cirrhosis or bile duct disease.
authors.affiliation: Liver Unit Jean Verdier Hospital, UPRES EA 3409, UFR SMBH, Université Paris 13, France. gisele.nkontchou@jvr.aphp.fr
authors.forename: Gisèle
authors.initials: G
authors.lastname: Nkontchou
authors.forename: Jeanne
authors.initials: J
authors.lastname: Tran Van Nhieu
authors.forename: Marianne
authors.initials: M
authors.lastname: Ziol
authors.forename: Iulia
authors.initials: I
authors.lastname: Tengher
authors.forename: Amel
authors.initials: A
authors.lastname: Mahmoudi
authors.forename: Dominique
authors.initials: D
authors.lastname: Roulot
authors.forename: Valérie
authors.initials: V
authors.lastname: Bourcier
authors.forename: Nathalie
authors.initials: N
authors.lastname: Ganne Carrie
authors.forename: Véronique
authors.initials: V
authors.lastname: Grando-Lemaire
authors.forename: Jean-Claude
authors.initials: JC
authors.lastname: Trinchet
authors.forename: Daniel
authors.initials: D
authors.lastname: Cherqui
authors.forename: Michel
authors.initials: M
authors.lastname: Beaugrand
mesh_terms: D000368:Aged; D001650:Bile Duct Neoplasms; D001653:Bile Ducts, Intrahepatic; D001706:Biopsy; D018281:Cholangiocarcinoma / Q000208:ethnology* / Q000473:pathology*; D005234:Fatty Liver / Q000208:ethnology / Q000473:pathology; D005235:Fatty Liver, Alcoholic / Q000208:ethnology / Q000473:pathology; D005260:Female; D005602:France / Q000453:epidemiology; D006801:Humans; D019190:Iron Overload / Q000208:ethnology / Q000473:pathology; D008099:Liver / Q000473:pathology*; D008113:Liver Neoplasms / Q000208:ethnology* / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D065626:Non-alcoholic Fatty Liver Disease; D015995:Prevalence; D012189:Retrospective Studies; D012307:Risk Factors; D013997:Time Factors; D044465:White People