title: Bioactive phenolics and terpenoids from Manglietia insignis.
abstract: Four new compounds, maninsigins A-D (1-4), including two new neolignans (1-2) and two new sesquiterpenes (3-4), as well as ten known compounds (5-14), were isolated from the leaves and stems of Manglietia insignis. Their structures were established on the basis of extensive spectroscopic analyses. In addition, some compounds were tested for their cytotoxic and neurite outgrowth-promoting activities, as well as their antagonistic activity toward FXR ligand.
authors.affiliation: State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, Yunnan, People's Republic of China
authors.forename: Shan-Zhai
authors.initials: SZ
authors.lastname: Shang
authors.forename: Ling-Mei
authors.initials: LM
authors.lastname: Kong
authors.forename: Li-Ping
authors.initials: LP
authors.lastname: Yang
authors.forename: Jing
authors.initials: J
authors.lastname: Jiang
authors.forename: Jin
authors.initials: J
authors.lastname: Huang
authors.forename: Hai-Bo
authors.initials: HB
authors.lastname: Zhang
authors.forename: Yi-Ming
authors.initials: YM
authors.lastname: Shi
authors.forename: Wei
authors.initials: W
authors.lastname: Zhao
authors.forename: Hong-Lin
authors.initials: HL
authors.lastname: Li
authors.forename: Huai-Rong
authors.initials: HR
authors.lastname: Luo
authors.forename: Yan
authors.initials: Y
authors.lastname: Li
authors.forename: Wei-Lie
authors.initials: WL
authors.lastname: Xiao
authors.forename: Han-Dong
authors.initials: HD
authors.lastname: Sun
mesh_terms: D000818:Animals; D045744:Cell Line, Tumor; D006801:Humans; D029562:Magnoliaceae / Q000737:chemistry*; D008958:Models, Molecular; D009474:Neurons / Q000187:drug effects; D010636:Phenols / Q000737:chemistry / Q000494:pharmacology*; D018515:Plant Leaves / Q000737:chemistry; D018547:Plant Stems / Q000737:chemistry; D051381:Rats; D013729:Terpenes / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D010636:Phenols; D013729:Terpenes