title: Evaluating the effects of pentoxifylline administration on experimental pressure sores in rats by biomechanical examinations.
abstract: This study used a biomechanical test to evaluate the effects of pentoxifylline administration on the wound healing process of an experimental pressure sore induced in rats. Under general anesthesia and sterile conditions, experimental pressure sores generated by no. 25 Halsted mosquito forceps were inflicted on 12 adult male rats. Pentoxifylline was injected intraperitoneally at a dose of 50 mg/kg daily from the day the pressure sore was generated, for a period of 20 days. At the end of 20 days, rats were sacrificed and skin samples extracted. Samples were biomechanically examined by a material testing instrument for maximum stress (N mm(2)), work up to maximum force (N), and elastic stiffness (N/mm). In the experimental group, maximum stress (2.05±0.15) and work up to maximum force (N/mm) (63.75±4.97) were significantly higher than the control group (1.3±0.27 and 43.3±14.96, P=0.002 and P=0.035, respectively). Pentoxifylline administration significantly accelerated the wound healing process in experimental rats with pressure sores, compared to that of the control group.
authors.affiliation: Cell and Molecular Biology Research Center and Anatomy Department, Medical Faculty, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
authors.forename: Kobra
authors.initials: K
authors.lastname: Velaei
authors.forename: Mohammad
authors.initials: M
authors.lastname: Bayat
authors.forename: Giti
authors.initials: G
authors.lastname: Torkman
authors.forename: Fatemealsadat
authors.initials: F
authors.lastname: Rezaie
authors.forename: Abdollah
authors.initials: A
authors.lastname: Amini
authors.forename: Mohsen
authors.initials: M
authors.lastname: Noruzian
authors.forename: Azaedh
authors.initials: A
authors.lastname: Tavassol
authors.forename: Mehernoush
authors.initials: M
authors.lastname: Bayat
keywords: Experimental model of pressure sore; biomechanical test; pentoxifylline; rat