title: Detection of fetal major structural anomalies at the 11-14 ultrasound scan in an unselected population.
abstract: OBJECTIVE
  The aim of the study was to determine the efficacy of the 11-14 week scan in detecting fetuses with structural anomalies.
  
  
  METHODS
  Prospective interventional study in an unselected population of pregnant women in a 5-year period (2003-2008) in a single ultrasound unit. 8889 fetuses with median CRL 65mm (45-84mm) were examined. Continuing pregnancies were rescanned at 20-22 weeks. Actual structural anomalies among newborns from the studied group were obtained from our computerized database.
  
  
  RESULTS
  The median maternal age was 30 years (14-50 years). The incidence of anomalies was 16.08 per 1000 (143/8889). Of these, 99 of the 143 were detected with prenatal sonography. 46.9% (67/143) of all anomalies were detected at the 11-14 week scan. Later in pregnancy, another 22.3% (32/143) of structural anomalies were detected.
  
  
  CONCLUSIONS
  67.7% of all antenatally detected malformations by ultrasound were recognized in the 11 14 week scan. Obviously, the second trimester scan cannot be abandoned, as it provides effective detection of other anomalies.
authors.affiliation: Department of Obstetrics and Gynecology, Charles University, Prague, Czech Republic.
authors.forename: M
authors.initials: M
authors.lastname: Novotná
authors.forename: L
authors.initials: L
authors.lastname: Hašlík
authors.forename: K
authors.initials: K
authors.lastname: Svabík
authors.forename: Z
authors.initials: Z
authors.lastname: Zižka
authors.forename: H
authors.initials: H
authors.lastname: Belošovičová
authors.forename: M
authors.initials: M
authors.lastname: Břešťák
authors.forename: P
authors.initials: P
authors.lastname: Calda
mesh_terms: D000293:Adolescent; D000328:Adult; D000013:Congenital Abnormalities / Q000000981:diagnostic imaging*; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D008875:Middle Aged; D011247:Pregnancy; D011261:Pregnancy Trimester, First; D016216:Ultrasonography, Prenatal; D055815:Young Adult