title: Diagnostic efficiency of amylase and type IV collagen in predicting chronic pancreatitis.
abstract: Chronic pancreatitis, an irreversible inflammatory disease of the pancreas, is associated with the replacement of the destroyed parenchyma by extended development of fibrosis. Despite marked progress in diagnostic tools, no consensus has been reached in diagnosis of chronic pancreatitis. In this study we examined the hematological and biochemical parameters among 40 chronic pancreatitis patients within 18 to 67 yrs. ESR level and ALP activity was elevated in 40% cases. Serum amylase activity increased in 32 patients and it showed significant correlation with ALP (r=0.458, p=0.003), CA-19.9 (r=0.556, p<0.001), and calcium level (r=-0.472, p=0.002). Type IV collagen level in chronic pancreatitis also elevated (164.4 ± 55.5 ng/ml) and showed negative significant correlation with calcium level (r= -0.505, p=0.001). However, no significant correlation was observed between amylase activity and type IV collagen (r=0.289, p= 0.07).
authors.affiliation: Department of Biochemistry, Amrita Institute of Medical Sciences, Elamakkara P.O., Cochin, 682 026 India  ; Department of Biochemistry, Agartala Govt. Medical College, Kunjaban P.O., Agartala, 799006 India.
authors.forename: Subir Kumar
authors.initials: SK
authors.lastname: Das
authors.forename: Sowmya
authors.initials: S
authors.lastname: Varadhan
authors.forename: L
authors.initials: L
authors.lastname: Dhanya
authors.forename: Sukhes
authors.initials: S
authors.lastname: Mukherjee
authors.forename: S
authors.initials: S
authors.lastname: Mohana
authors.forename: V
authors.initials: V
authors.lastname: Balakrishnan
authors.forename: D M
authors.initials: DM
authors.lastname: Vasudevan
keywords: Amylase; Chronic pancreatitis; Fibrosis; Type IV Collagen