title: Epithelial mesenchymal transition in drug resistance and metastasis of lung cancer.
abstract: Among all types of cancer, incidence of lung cancer remains the highest with regard to cancer-related mortality. Problems contributing to recurrence of the disease include metastasis and drug resistance. Mounting evidence has demonstrated involvement of epithelial mesenchymal transition (EMT) in cancer progression. EMT is a critical mechanism ensuring tissue remodeling during morphogenesis of multicellular organisms. Therefore, understanding of the biology of this process for identification of potential EMT-targeted therapeutic strategies for the benefit cancer patients is necessary. This review describes recent evidence of EMT involvement in drug resistance and metastasis of cancers, with an emphasis on lung cancer.
authors.affiliation: Department of Respiratory Medicine, Juntendo University School of Medicine, Tokyo, Japan.
authors.forename: Fariz
authors.initials: F
authors.lastname: Nurwidya
authors.forename: Fumiyuki
authors.initials: F
authors.lastname: Takahashi
authors.forename: Akiko
authors.initials: A
authors.lastname: Murakami
authors.forename: Kazuhisa
authors.initials: K
authors.lastname: Takahashi
keywords: Drug resistance; Epithelial-mesenchymal transition; Lung neoplasms; Neoplasm metastasis