title: Preliminary study of renal hemodynamic alteration in early childhood diabetes mellitus.
abstract: Renal hemodynamic study was performed in eight patients associated with type 1, early childhood diabetes mellitus (DM) and seven patients associated with type 2, early childhood DM. The results in both types of DM revealed a significant reduction in peritubular capillary flow and a high value of glomerular filtration rate (GFR) in the presence of reduced renal perfusion characteristic of glomerular hyperfiltration. These findings imply that renal ischemia has already developed in both types of early stage childhood DM and GFR is overestimated in DM, which may mislead to improper interpretation of renal function.
authors.affiliation: Department of Pediatrics, Faculty of Medicine, King Chulalongkorn Memorial Hospital, Chulalongkorn University, Bangkok, Thailand. Wacharasindhu@yahoo.com
authors.forename: Suttipong
authors.initials: S
authors.lastname: Wacharasindhu
authors.forename: Rottanat
authors.initials: R
authors.lastname: Rugpolmuang
authors.forename: Thapana
authors.initials: T
authors.lastname: Roonghiranwat
authors.forename: Vichit
authors.initials: V
authors.lastname: Supornsilchai
authors.forename: Taninee
authors.initials: T
authors.lastname: Sahakitrungruang
authors.forename: Suphab
authors.initials: S
authors.lastname: Aroonparkmongkol
authors.forename: Tawatchai
authors.initials: T
authors.lastname: Chaiwatanarat
mesh_terms: D000293:Adolescent; D003920:Diabetes Mellitus / Q000503:physiopathology* / Q000652:urine; D003928:Diabetic Nephropathies / Q000175:diagnosis / Q000503:physiopathology / Q000652:urine; D018450:Disease Progression; D005260:Female; D005919:Glomerular Filtration Rate; D006801:Humans; D007668:Kidney / Q000098:blood supply* / Q000503:physiopathology; D008274:Magnesium / Q000652:urine; D008297:Male; D011379:Prognosis; D012039:Regional Blood Flow / Q000502:physiology*; D012079:Renal Circulation / Q000502:physiology*
chemical_list: D008274:Magnesium