title: Effects of Aerobic Fitness and Adiposity on Coagulation Biomarkers in Men vs. Women with Elevated Blood Pressure.
abstract: A hypercoagulable state is a potential mechanism linking elevated blood pressure (BP), adiposity and a sedentary lifestyle to development of coronary heart disease (CHD). We examined relationships among aerobic fitness and adiposity in 76 sedentary subjects with elevated BP. Blood levels of plasminogen activator inhibitor-1 (PAI-1), D-dimer, von Willebrand factor (vWF) and thrombomodulin were assessed as biomarkers of coagulation. In individuals with elevated BP, percent body fat and fitness were associated with biomarkers indicative of a hypercoagulable state, even after demographic and metabolic factors were considered. D-dimer was positively associated with percent body fat (beta=0.37, p=0.003). PAI-1 was higher in men than in women (beta=-0.31, p=0.015) and associated with lower VO2peak (beta=-0.35, p=0.024). Thrombomodulin was positively associated with VO2peak (beta=0.56, p< 0.01). vWF was not significantly associated with fitness or adiposity. Our results emphasise that both percent body fat and physical fitness are important in the maintenance of haemostatic balance.
authors.affiliation: Department of Psychiatry, University of California, San Diego, California.
authors.forename: Kathleen L
authors.initials: KL
authors.lastname: Wilson
authors.forename: Lianne
authors.initials: L
authors.lastname: Tomfohr
authors.forename: Kate
authors.initials: K
authors.lastname: Edwards
authors.forename: Cindy
authors.initials: C
authors.lastname: Knott
authors.forename: Suzi
authors.initials: S
authors.lastname: Hong
authors.forename: Laura
authors.initials: L
authors.lastname: Redwine
authors.forename: Karen
authors.initials: K
authors.lastname: Calfas
authors.forename: Cheryl L
authors.initials: CL
authors.lastname: Rock
authors.forename: Roland
authors.initials: R
authors.lastname: von Känel
authors.forename: Paul J
authors.initials: PJ
authors.lastname: Mills