title: Cushing syndrome in pediatrics.
abstract: Cushing syndrome is characterized by truncal obesity, growth deceleration, skin changes, muscle weakness, and hypertension. Cushing syndrome in childhood usually results from the exogenous administration of glucocorticoids. This article presents the causes and discusses the treatment of endogenous Cushing syndrome. It also discusses the clinical and molecular genetics of inherited forms of this syndrome. Cushing syndrome needs to be diagnosed and treated properly when first recognized; improper treatment can turn this otherwise completely curable disorder into a chronic ailment. Barriers to optimal care of a pediatric patient with Cushing syndrome are discussed.
authors.affiliation: Section on Endocrinology and Genetics, Program in Developmental Endocrinology and Genetics, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892-1862, USA. stratakc@mail.nih.gov
authors.forename: Constantine A
authors.initials: CA
authors.lastname: Stratakis
mesh_terms: D000236:Adenoma / Q000150:complications / Q000175:diagnosis / Q000628:therapy; D000310:Adrenal Gland Neoplasms / Q000150:complications / Q000175:diagnosis / Q000628:therapy; D002648:Child; D003480:Cushing Syndrome / Q000175:diagnosis / Q000209:etiology / Q000628:therapy; D005938:Glucocorticoids / Q000009:adverse effects*; D006801:Humans; D047748:Pituitary ACTH Hypersecretion / Q000150:complications / Q000175:diagnosis / Q000628:therapy; D010911:Pituitary Neoplasms / Q000150:complications / Q000175:diagnosis / Q000628:therapy
chemical_list: D005938:Glucocorticoids