title: Corticosteroid therapy in genotype ST-11 meningococcal infections.
abstract: Corticosteroid treatment for meningococcal disease is debated. We report a high risk of death (odds ratio 4.68, 95% confidence interval: 1.91-11.46; P = 0.001) without corticosteroid treatment when meningococcal disease is provoked by isolates belonging to the hyperinvasive genotype ST-11. Genotypes of meningococcal isolates should be considered with corticosteroids therapy for meningococcal disease.
authors.affiliation: Service de Pédiatrie, Centre Hospitalier Intercommunal, Paris, France.
authors.forename: Fouad
authors.initials: F
authors.lastname: Madhi
authors.forename: Corinne
authors.initials: C
authors.lastname: Levy
authors.forename: Ala Eddine
authors.initials: AE
authors.lastname: Deghmane
authors.forename: Stéphane
authors.initials: S
authors.lastname: Béchet
authors.forename: Robert
authors.initials: R
authors.lastname: Cohen
authors.forename: Muhamed-Kheir
authors.initials: MK
authors.lastname: Taha
mesh_terms: D000293:Adolescent; D000305:Adrenal Cortex Hormones / Q000627:therapeutic use*; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use*; D002648:Child; D002675:Child, Preschool; D005260:Female; D005838:Genotype; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D008589:Meningococcal Infections / Q000188:drug therapy* / Q000382:microbiology / Q000401:mortality*; D009345:Neisseria meningitidis / Q000145:classification / Q000235:genetics / Q000302:isolation & purification; D016019:Survival Analysis
chemical_list: D000305:Adrenal Cortex Hormones; D000893:Anti-Inflammatory Agents