title: Serum markers for early diagnosis of non-'Q' wave and 'Q' wave myocardial infarction.
abstract: The present study conducted on twenty-five uncomplicated cases of acute myocardial infarction diagnosed by clinical and electrocardiographic findings indicated significantly increased level of cardiac Troponin-T and increased activities of the enzymes total creatine kinase, creatine kinase-MB, aspartate transaminase and lactate dehydrogenase as compared to the twenty-five healthy control subjects. The level of cardiac Troponin-T and the activities of the enzymes total creatine kinase, creatine kinase-MB, aspartate transaminase and lactate dehydrogenase was found to be higher in "Q" wave myocardial infarction patients as compared to the non-"Q" wave and the controls. Since cardiac Troponin-T has been shown to increase in unstable angina and renal failure without cardiac disease and creatine kinase-MB activity has been found to be normal in patients with unstable angina and increase very slightly in patients with renal failure, it was concluded that a combination of cardiac Troponin-T and creatine kinase-MB activity was sufficient for the early diagnosis of acute myocardial infarction.
authors.affiliation: Department of Biochemistry and Biophysics, St. John's Medical College, SJNAHS, 560 034 Bangalore.
authors.forename: Alka
authors.initials: A
authors.lastname: Singh
authors.forename: Sheila
authors.initials: S
authors.lastname: Uthappa
authors.forename: V
authors.initials: V
authors.lastname: Govindaraju
authors.forename: T
authors.initials: T
authors.lastname: Venkatesh
keywords: AMI; cardiac Troponin-T; serum cardiac markers