title: Osteoarthritis, inflammation and obesity.
abstract: OBJECTIVE
  Obesity is one of the main risk factors of the incidence and prevalence of knee osteoarthritis. Recent epidemiological data showing an increased risk of hand osteoarthritis in obese patients opened the door to a role of systemic inflammatory mediators, adipokines, released by adipose tissue.
  
  
  RESULTS
  Recent experimental studies confirm the critical roles of adipokines in the pathophysiologic features of osteoarthritis, with an emphasis on a new member, chemerin. Animal models of diet-induced obesity show that overload cannot completely explain the aggravation of spontaneous or posttraumatic knee osteoarthritis. We now have data suggesting that some adipokines may be surrogate biomarkers for severity of osteoarthritis.
  
  
  CONCLUSIONS
  Preclinical studies targeting adipokines are now expected to provide new hope for patients with osteoarthritis, especially those with metabolic syndrome.
authors.affiliation: University Pierre and Marie Curie, Paris VI, Sorbonne Universités, Paris, France. francis.berenbaum@sat.aphp.fr
authors.forename: Francis
authors.initials: F
authors.lastname: Berenbaum
authors.forename: Florent
authors.initials: F
authors.lastname: Eymard
authors.forename: Xavier
authors.initials: X
authors.lastname: Houard
mesh_terms: D054392:Adipokines / Q000097:blood / Q000502:physiology; D000818:Animals; D001169:Arthritis, Experimental / Q000209:etiology; D015415:Biomarkers / Q000097:blood; D006801:Humans; D007249:Inflammation / Q000150:complications*; D051379:Mice; D009765:Obesity / Q000150:complications*; D010003:Osteoarthritis / Q000175:diagnosis / Q000209:etiology*; D020370:Osteoarthritis, Knee / Q000209:etiology; D011817:Rabbits
chemical_list: D054392:Adipokines; D015415:Biomarkers