title: Wound healing in development.
abstract: Wound healing is the inherent ability of an organism to protect itself against injuries. Cumulative evidence indicates that the healing process patterns in part embryonic morphogenesis and may result in either organ regeneration or scarring, phenomena that are developmental stage- or age-dependent. Skin is the largest organ. Its morphogenesis and repair mechanisms have been studied extensively due not only to its anatomical location, which allows easy access and observation, but also to its captivating structure and vital function. Thus, this review will focus on using skin as a model organ to illustrate new insights into the mechanisms of wound healing that are developmentally regulated in mammals, with special emphasis on the role of the Wnt signaling pathway and its crosstalk with TGF-β signaling. Relevant information from studies of other organs is discussed where it applies, and the clinical impact from such knowledge and emerging concepts on regenerative medicine are discussed in perspective.
authors.affiliation: Division of Developmetal Biology, Regenerative Medicine, and Surgery, The Saban Research Institute of Children's Hospital Los Angeles, California, USA.
authors.forename: Yun-Shain
authors.initials: YS
authors.lastname: Lee
authors.forename: Annette
authors.initials: A
authors.lastname: Wysocki
authors.forename: David
authors.initials: D
authors.lastname: Warburton
authors.forename: Tai-Lan
authors.initials: TL
authors.lastname: Tuan
mesh_terms: D000367:Age Factors; D000818:Animals; D006801:Humans; D008322:Mammals / Q000254:growth & development*; D009024:Morphogenesis / Q000502:physiology*; D058628:Myofibroblasts / Q000502:physiology; D044968:Regenerative Medicine / Q000379:methods*; D012879:Skin Physiological Phenomena; D013045:Species Specificity; D014157:Transcription Factors / Q000378:metabolism*; D016212:Transforming Growth Factor beta / Q000378:metabolism; D060449:Wnt Signaling Pathway / Q000502:physiology*; D014945:Wound Healing / Q000502:physiology*
chemical_list: D014157:Transcription Factors; D016212:Transforming Growth Factor beta