title: [Sex-hormone binding globulin (SHBG) levels during pregnancy as predictors for pre-eclampsia and fetal growth restriction].
abstract: BACKGROUND
  Sex-Hormone Binding Globulin (SHBG) may be associated to Pre-eclampsia (PE) and Fetal Growth Restriction (RCIU).
  
  
  OBJECTIVE
  To determine if maternal serum SHBG concentrations during the first and second trimesters are predictive biomarkers of Pre-eclampsia and RCIU.
  
  
  METHODS
  Prospective cohort study carried out in the Fetal Medicine Unit, Universidad de Chile Clinical Hospital between January, 2005 and December, 2006. Blood samples were obtained from unselected pregnant women during routine 11-14 week and 22-25 week ultrasound examinations, conforming two different study groups. Posteriorly, serum SHBG concentrations were determined in women who developed Pre-eclampsia, RCIU and their respective controls.
  
  
  RESULTS
  Fifty five patients were included in the 11-14 weeks group. Nine women that developed PE, 10 that developed RCIU and 36 controls were selected from this group. There were no significant differences in SHBG levels between patients with PE, RCIU or controls (324.7 (26.6), 336.8 (33.9) and 377.5 (24.3) nmol/L, respectively). Fifty four women were included in the 22-25 weeks group. Eight women who developed Pre-eclampsia, 15 who developed RCIU and 31 controls were selected. Again, there were no significant differences in SHBG levels between patients with PE, RCIU or controls (345.5 (151.1), 383.8 (143.4) and 345.5 nmol/l (151.1), respectively).
  
  
  CONCLUSIONS
  Maternal SHBG serum levels did not predict subsequent development of Pre-eclampsia and RCIU.
authors.affiliation: Unidad de Medicina Fetal, Departamento de Obstetricia y Ginecología, Hospital Clínico de la Universidad de Chile, Santiago, Chile. evaldes@vtr.net
authors.forename: Enrique
authors.initials: E
authors.lastname: Valdés R
authors.forename: Karina
authors.initials: K
authors.lastname: Lattes A
authors.forename: Hernán
authors.initials: H
authors.lastname: Muñoz S
authors.forename: Miguel Angel
authors.initials: MA
authors.lastname: Cumsille
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000097:blood; D016022:Case-Control Studies; D005260:Female; D005317:Fetal Growth Retardation / Q000097:blood*; D006801:Humans; D011225:Pre-Eclampsia / Q000097:blood*; D011237:Predictive Value of Tests; D011247:Pregnancy; D011261:Pregnancy Trimester, First; D011262:Pregnancy Trimester, Second; D012307:Risk Factors; D012738:Sex Hormone-Binding Globulin / Q000378:metabolism*; D055815:Young Adult
chemical_list: D015415:Biomarkers; D012738:Sex Hormone-Binding Globulin