title: Langerhans cell histiocytosis (LCH): guidelines for diagnosis, clinical work-up, and treatment for patients till the age of 18 years.
abstract: These guidelines for the management of patients up to 18 years with Langerhans cell histiocytosis (LCH) have been set up by a group of experts involved in the Euro Histio Net project who participated in national or international studies and in peer reviewed publications. Existing guidelines were reviewed and changed where new evidence was available in the literature up to 2012. Data and publications have been ranked according to evidence based medicine and when there was a lack of published data, consensus between experts was sought. Guidelines for diagnosis, initial clinical work-up, and treatment and long-term follow-up of LCH patients are presented.
authors.affiliation: Department of Hematology and Oncology, Epidemiology and Biostatistics Section, Istituto G. Gaslini, Genova, Italy.
authors.forename: Riccardo
authors.initials: R
authors.lastname: Haupt
authors.forename: Milen
authors.initials: M
authors.lastname: Minkov
authors.forename: Itziar
authors.initials: I
authors.lastname: Astigarraga
authors.forename: Eva
authors.initials: E
authors.lastname: Schäfer
authors.forename: Vasanta
authors.initials: V
authors.lastname: Nanduri
authors.forename: Rima
authors.initials: R
authors.lastname: Jubran
authors.forename: R Maarten
authors.initials: RM
authors.lastname: Egeler
authors.forename: Gritta
authors.initials: G
authors.lastname: Janka
authors.forename: Dragan
authors.initials: D
authors.lastname: Micic
authors.forename: Carlos
authors.initials: C
authors.lastname: Rodriguez-Galindo
authors.forename: Stefaan
authors.initials: S
authors.lastname: Van Gool
authors.forename: Johannes
authors.initials: J
authors.lastname: Visser
authors.forename: Sheila
authors.initials: S
authors.lastname: Weitzman
authors.forename: Jean
authors.initials: J
authors.lastname: Donadieu
mesh_terms: D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D006646:Histiocytosis, Langerhans-Cell / Q000175:diagnosis* / Q000628:therapy*; D006801:Humans