title: The shuttling scaffold model for prevention of yeast pheromone pathway misactivation.
abstract: The molecular scaffold in the yeast pheromone pathway, Ste5, shuttles continuously between the nucleus and the cytoplasm. Ste5 undergoes oligomerization reaction in the nucleus. Upon pheromone stimulation, the Ste5 dimer is rapidly exported out of the nucleus and recruited to the plasma membrane for pathway activation. This clever device on part of the yeast cell is thought to prevent pathway misactivation at high enough levels of Ste5 in the absence of pheromone. We have built a spatiotemporal model of signaling in this pathway to describe its regulation. Our present work underscores the importance of spatial modeling of cell signaling networks to understand their control and functioning.
authors.affiliation: aps6dl@yahoo.com
authors.forename: Aditya P
authors.initials: AP
authors.lastname: Singh
authors.forename: Erik
authors.initials: E
authors.lastname: Andries
authors.forename: Jeremy S
authors.initials: JS
authors.lastname: Edwards
authors.forename: Stanly
authors.initials: S
authors.lastname: Steinberg
mesh_terms: D021581:Active Transport, Cell Nucleus; D048868:Adaptor Proteins, Signal Transducing / Q000737:chemistry / Q000378:metabolism; D020935:MAP Kinase Signaling System; D055641:Mathematical Concepts; D008954:Models, Biological; D010675:Pheromones / Q000378:metabolism*; D012441:Saccharomyces cerevisiae / Q000378:metabolism*; D029701:Saccharomyces cerevisiae Proteins / Q000737:chemistry / Q000378:metabolism
chemical_list: D048868:Adaptor Proteins, Signal Transducing; D010675:Pheromones; C080321:STE5 protein, S cerevisiae; D029701:Saccharomyces cerevisiae Proteins