title: Neural progenitor cells regulate microglia functions and activity.
abstract: We found mouse neural progenitor cells (NPCs) to have a secretory protein profile distinct from other brain cells and to modulate microglial activation, proliferation and phagocytosis. NPC-derived vascular endothelial growth factor was necessary and sufficient to exert at least some of these effects in mice. Thus, neural precursor cells may not only be shaped by microglia, but also regulate microglia functions and activity.
authors.affiliation: Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, California, USA.
authors.forename: Kira I
authors.initials: KI
authors.lastname: Mosher
authors.forename: Robert H
authors.initials: RH
authors.lastname: Andres
authors.forename: Takeshi
authors.initials: T
authors.lastname: Fukuhara
authors.forename: Gregor
authors.initials: G
authors.lastname: Bieri
authors.forename: Maiko
authors.initials: M
authors.lastname: Hasegawa-Moriyama
authors.forename: Yingbo
authors.initials: Y
authors.lastname: He
authors.forename: Raphael
authors.initials: R
authors.lastname: Guzman
authors.forename: Tony
authors.initials: T
authors.lastname: Wyss-Coray
mesh_terms: D000704:Analysis of Variance; D000818:Animals; D000831:Animals, Newborn; D015703:Antigens, CD; D015214:Antigens, Differentiation, Myelomonocytic; D001921:Brain / Q000166:cytology; D001973:Bromodeoxyuridine / Q000378:metabolism; D002135:Calcium-Binding Proteins / Q000378:metabolism; D049109:Cell Proliferation / Q000187:drug effects; D017690:Cell Transplantation / Q000379:methods; D002478:Cells, Cultured; D002633:Chemotaxis / Q000187:drug effects; D017077:Culture Media, Conditioned / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D004622:Embryo, Mammalian; D005786:Gene Expression Regulation / Q000187:drug effects; D005904:Glial Fibrillary Acidic Protein / Q000378:metabolism; D049452:Green Fluorescent Proteins / Q000235:genetics; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008822:Mice, Transgenic; D008840:Microfilament Proteins / Q000378:metabolism; D017628:Microglia / Q000187:drug effects / Q000502:physiology*; D058953:Neural Stem Cells / Q000502:physiology*; D010587:Phagocytosis / Q000187:drug effects / Q000502:physiology; D040901:Proteomics / Q000379:methods; D034741:RNA, Small Interfering / Q000378:metabolism; D055748:SOXB1 Transcription Factors / Q000378:metabolism; D042461:Vascular Endothelial Growth Factor A / Q000378:metabolism / Q000494:pharmacology; D000097382:CD68 Molecule
chemical_list: D015703:Antigens, CD; D015214:Antigens, Differentiation, Myelomonocytic; D001973:Bromodeoxyuridine; D002135:Calcium-Binding Proteins; D017077:Culture Media, Conditioned; D005904:Glial Fibrillary Acidic Protein; D049452:Green Fluorescent Proteins; D008840:Microfilament Proteins; D034741:RNA, Small Interfering; D055748:SOXB1 Transcription Factors; D042461:Vascular Endothelial Growth Factor A; C491049:Aif1 protein, mouse; C081026:CD68 protein, mouse; D000097382:CD68 Molecule; C527783:Sox2 protein, mouse