title: Vasopressin/oxytocin-related signaling regulates gustatory associative learning in C. elegans.
abstract: Vasopressin- and oxytocin-related neuropeptides are key regulators of animal physiology, including water balance and reproduction. Although these neuropeptides also modulate social behavior and cognition in mammals, the mechanism for influencing behavioral plasticity and the evolutionary origin of these effects are not well understood. Here, we present a functional vasopressin- and oxytocin-like signaling system in the nematode Caenorhabditis elegans. Through activation of its receptor NTR-1, a vasopressin/oxytocin-related neuropeptide, designated nematocin, facilitates the experience-driven modulation of salt chemotaxis, a type of gustatory associative learning in C. elegans. Our study suggests that vasopressin and oxytocin neuropeptides have ancient roles in modulating sensory processing in neural circuits that underlie behavioral plasticity.
authors.affiliation: Department of Biology, Functional Genomics and Proteomics Unit, KU Leuven, 3000 Leuven, Belgium.
authors.forename: Isabel
authors.initials: I
authors.lastname: Beets
authors.forename: Tom
authors.initials: T
authors.lastname: Janssen
authors.forename: Ellen
authors.initials: E
authors.lastname: Meelkop
authors.forename: Liesbet
authors.initials: L
authors.lastname: Temmerman
authors.forename: Nick
authors.initials: N
authors.lastname: Suetens
authors.forename: Suzanne
authors.initials: S
authors.lastname: Rademakers
authors.forename: Gert
authors.initials: G
authors.lastname: Jansen
authors.forename: Liliane
authors.initials: L
authors.lastname: Schoofs
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D005075:Biological Evolution; D017173:Caenorhabditis elegans / Q000235:genetics / Q000502:physiology*; D029742:Caenorhabditis elegans Proteins / Q000819:agonists / Q000737:chemistry / Q000235:genetics / Q000378:metabolism / Q000494:pharmacology / Q000502:physiology*; D007858:Learning / Q000187:drug effects / Q000502:physiology*; D008297:Male; D008969:Molecular Sequence Data; D009479:Neuropeptides / Q000737:chemistry / Q000235:genetics / Q000494:pharmacology / Q000502:physiology*; D010121:Oxytocin / Q000737:chemistry / Q000235:genetics / Q000494:pharmacology / Q000502:physiology*; D043562:Receptors, G-Protein-Coupled / Q000819:agonists / Q000235:genetics / Q000378:metabolism / Q000502:physiology*; D015398:Signal Transduction; D013649:Taste / Q000187:drug effects / Q000502:physiology*; D014667:Vasopressins / Q000737:chemistry / Q000235:genetics / Q000494:pharmacology / Q000502:physiology*
chemical_list: D029742:Caenorhabditis elegans Proteins; C576185:NTR-1 protein, C elegans; C576186:NTR-2 protein, C elegans; D009479:Neuropeptides; D043562:Receptors, G-Protein-Coupled; C576184:ntc-1 protein, C elegans; D014667:Vasopressins; D010121:Oxytocin