title: Comparing beneficial effects of inhaled nitric oxide to L-arginine in necrotizing enterocolitis model in neonatal rats.
abstract: OBJECTIVE
  Necrotizing enterocolitis (NEC) is a common and devastating gastrointestinal condition of neonatal infants. The pathophysiology of NEC remains poorly understood. We tried to evaluate the effectiveness of inhaled NO compared to L-arginine usage in necrotizing enterocolitis model in rats.
  
  
  METHODS
  46 newborn pups from 4 time-mated Sprague-Dawley pregnant rats were divided equally into 4 groups as follows: NEC (subjected to NEC), NEC + L-arginine, NEC + inhaled NO and control.
  
  
  RESULTS
  SOD, GSH-Px and NOx levels were significantly higher and MDA levels were significantly lower in NEC + inhaled NO group compared to NEC + L-arginine group. There was significantly lower intestinal injury and apoptosis index scoring in NEC + inhaled NO group compared to NEC + L-arginine group.
  
  
  CONCLUSIONS
  We think that inhaled NO can be used as a novel therapeutic agent like L-arginine in NEC, like using in pulmonary hypertention in newborns but much more studies are needed.
authors.affiliation: Department of Pediatrics, GATA Medical Faculty, Ankara, Turkey. ferhat_cocuk@hotmail.com
authors.forename: Ferhat
authors.initials: F
authors.lastname: Çekmez
authors.forename: Tarık
authors.initials: T
authors.lastname: Purtuloğlu
authors.forename: Gokhan
authors.initials: G
authors.lastname: Aydemir
authors.forename: Secil
authors.initials: S
authors.lastname: Aydinoz
authors.forename: Kürşat
authors.initials: K
authors.lastname: Fidancı
authors.forename: Abdülbaki
authors.initials: A
authors.lastname: Karaoğlu
authors.forename: Oğuzhan
authors.initials: O
authors.lastname: Babacan
authors.forename: Fuat Emre
authors.initials: FE
authors.lastname: Canpolat
authors.forename: Merih
authors.initials: M
authors.lastname: Cetinkaya
authors.forename: Turan
authors.initials: T
authors.lastname: Tunc
authors.forename: Selami
authors.initials: S
authors.lastname: Süleymanoglu
mesh_terms: D000280:Administration, Inhalation; D000818:Animals; D000831:Animals, Newborn; D001120:Arginine / Q000627:therapeutic use*; D004195:Disease Models, Animal; D020345:Enterocolitis, Necrotizing / Q000188:drug therapy*; D009569:Nitric Oxide / Q000008:administration & dosage*; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D009569:Nitric Oxide; D001120:Arginine