title: Cutl1: a potential target for cancer therapy.
abstract: CDP, a key transcription regulator encoded by Cutl1 gene, has been demonstrated to be involved in repressing or promoting expression of target genes through its specific DNA-binding, meanwhile, the activity of CDP was influenced by some types of modifications including transcriptional, posttranscriptional, translational and posttranslational modifications. In this review, we systematically analyzed the role of CDP in normal development and tumor progression, and then emphasized its interactors and downstream molecules. Eventually, we concluded that Cut1 could promote cancer progression and its down-regulating expression will be a promising strategy for cancer therapy.
authors.affiliation: Institute for Laboratory Medicine, Fuzhou General Hospital, PLA, Fuzhou, Fujian 350025, PR China.
authors.forename: Kuan-can
authors.initials: KC
authors.lastname: Liu
authors.forename: Bao-shun
authors.initials: BS
authors.lastname: Lin
authors.forename: Meng
authors.initials: M
authors.lastname: Zhao
authors.forename: Kai-yu
authors.initials: KY
authors.lastname: Wang
authors.forename: Xiao-peng
authors.initials: XP
authors.lastname: Lan
mesh_terms: D018450:Disease Progression; D018398:Homeodomain Proteins / Q000037:antagonists & inhibitors / Q000378:metabolism*; D006801:Humans; D009369:Neoplasms / Q000378:metabolism / Q000473:pathology / Q000628:therapy*; D009687:Nuclear Proteins / Q000037:antagonists & inhibitors / Q000378:metabolism*; D019869:Phosphatidylinositol 3-Kinases / Q000378:metabolism; D051057:Proto-Oncogene Proteins c-akt / Q000378:metabolism; D012097:Repressor Proteins / Q000037:antagonists & inhibitors / Q000378:metabolism*; D015398:Signal Transduction; D014157:Transcription Factors; D016212:Transforming Growth Factor beta / Q000378:metabolism
chemical_list: D018398:Homeodomain Proteins; D009687:Nuclear Proteins; D019869:Phosphatidylinositol 3-Kinases; D051057:Proto-Oncogene Proteins c-akt; D012097:Repressor Proteins; D014157:Transcription Factors; D016212:Transforming Growth Factor beta; C080632:CUX1 protein, human