title: When secondary comes first--the importance of non-canonical DNA structures.
abstract: Secondary structure-forming DNA motifs have achieved infamy because of their association with a variety of human diseases and cancer. The 3rd FASEB summer conference on dynamic DNA structures focused on the mechanisms responsible for the instabilities inherent to repetitive DNA and presented many exciting and novel aspects related to the metabolism of secondary structures. In addition, the meeting encompassed talks and posters on the dynamic structures that are generated during DNA metabolism including nicked DNA, Holliday junctions and RNA:DNA hybrids. New approaches for analysis and sequencing technologies put forth secondary structures and other DNA intermediates as vital regulators of a variety of cellular processes that contribute to evolution, polymorphisms and diseases.
authors.affiliation: School of Biology and Institute for Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta, GA 30332, USA.
authors.forename: Natalie
authors.initials: N
authors.lastname: Saini
authors.forename: Yu
authors.initials: Y
authors.lastname: Zhang
authors.forename: Karen
authors.initials: K
authors.lastname: Usdin
authors.forename: Kirill S
authors.initials: KS
authors.lastname: Lobachev
mesh_terms: D000818:Animals; D001419:Bacteria / Q000737:chemistry; D004247:DNA / Q000737:chemistry* / Q000235:genetics; D045566:DNA, Cruciform / Q000737:chemistry* / Q000235:genetics; D019143:Evolution, Molecular; D054856:G-Quadruplexes; D006801:Humans; D012313:RNA / Q000737:chemistry; D020080:Tandem Repeat Sequences
chemical_list: D045566:DNA, Cruciform; C051802:triplex DNA; D012313:RNA; D004247:DNA