title: Arginine-containing tripeptide Pro-Arg-Gly is involved in the regulation of the function of anticoagulation and insular systems under persistent hyperglycemia.
abstract: Intranasal administration of regulatory peptide PRG to rats against the background of persistent hyperglycemia improves blood antiplatelet and anticoagulant-fibrinolytic potential and normalizes blood sugar in comparison with the corresponding parameters in control animals that did not receive the peptide. The fibrinolytic and antiplatelet activities of blood plasma remained elevated 6 days after peptide withdrawal against the background of unchanged glucose administration.
authors.affiliation: Institute of Molecular Genetics, Russian Academy of Science, Moscow, Russia.
authors.forename: L A
authors.initials: LA
authors.lastname: Andreeva
authors.forename: N F
authors.initials: NF
authors.lastname: Myasoedov
authors.forename: T A
authors.initials: TA
authors.lastname: Shubina
authors.forename: M E
authors.initials: ME
authors.lastname: Grigorieva
authors.forename: L A
authors.initials: LA
authors.lastname: Ljapina
mesh_terms: D000281:Administration, Intranasal; D000818:Animals; D001120:Arginine / Q000737:chemistry / Q000494:pharmacology; D001786:Blood Glucose / Q000032:analysis; D003921:Diabetes Mellitus, Experimental / Q000188:drug therapy / Q000503:physiopathology*; D003924:Diabetes Mellitus, Type 2 / Q000188:drug therapy / Q000503:physiopathology*; D004151:Dipeptides / Q000737:chemistry; D005174:Factor XII / Q000378:metabolism; D005342:Fibrinolysis / Q000187:drug effects; D005343:Fibrinolytic Agents / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology*; D005947:Glucose / Q000008:administration & dosage; D008297:Male; D009842:Oligopeptides / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology*; D010314:Partial Thromboplastin Time; D010975:Platelet Aggregation Inhibitors / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology*; D051381:Rats; D010959:Tissue Plasminogen Activator / Q000378:metabolism
chemical_list: D001786:Blood Glucose; D004151:Dipeptides; D005343:Fibrinolytic Agents; D009842:Oligopeptides; D010975:Platelet Aggregation Inhibitors; C057749:prolylglycine; D005174:Factor XII; D001120:Arginine; D010959:Tissue Plasminogen Activator; D005947:Glucose