title: Antagonistic effect of FePP on the ethanol mediated induction of hepatic, renal and splenic δ-amino levulinic acid synthase activityin vivo in rats.
abstract: In the current study, we report perturbations in hepatic, renal and splenic heme synthesis at the level of the rate limiting enzyme, δ-amino levulinic acid synthase (ALA-S) on ethanol administration independently and in conjunction with iron-protoporphyrin (FePP) in male Wistar rats. Excessive ethanol administration (5 ml/kg bw) resulted in a significant induction of hepatic, splenic and renal ALA-S activity. Simultaneous administration of FePP (50 μmol/kg bw) reverted the observed induction response to a sharp decline. The features of the action of ethanol and FePP togetherin vivo, i.e. a substantial inhibition of ALA-S is suggestive of the beneficial effects of this formulation in acute attacks of porphyria.
authors.affiliation: B.R. Ambedkar Center for Biomedical Research, University of Delhi, 110007 Delhi, India.
authors.forename: R
authors.initials: R
authors.lastname: Chandra
authors.forename: R
authors.initials: R
authors.lastname: Aneja
authors.forename: C
authors.initials: C
authors.lastname: Rewal
authors.forename: S
authors.initials: S
authors.lastname: Bhowmik
authors.forename: S K
authors.initials: SK
authors.lastname: Dass
authors.forename: R
authors.initials: R
authors.lastname: Jain
keywords: Ethanol; Heme biosynthesis; Iron Protoporphyrin (FePP); delta-amino levulinic acid synthase (ALA-S)