title: Repeated moderate stress stimulates the production of dehydroepiandrosterone sulfate (DHEAS) and reduces corticosteroid imbalance in old Macaca Mulatta.
abstract: Young (6-8 years) and old (21-30 years) Macaca mulatta females were subjected to gentle immobilization (2 h daily at 15.00) for 10 days. Blood specimens were collected before the exposure and 15, 30, 60, 120, 240 min and 24 h after the beginning of exposure on days 1, 3, and 10. The adrenocortical reaction to stress was maximum on day 1 in all animals. The increase of cortisol (F) and dehydroepiandrosterone sulfate (DHEAS) concentrations in young monkeys decreased on days 3 and 10, DHEAS drop being less pronounced in comparison with F, as a result of which F/DHEAS molar concentration ratio changed negligibly. In old monkeys the basal DHEAS levels were lower, while the F/DHEAS ratio was higher than in young animals. Repeated immobilizations inhibited F elevation on day 3, caused no changes in DHEAS reaction, led to increase of basal DHEAS levels and to a reduction of F/DHEAS ratio on days 2, 3, 4, 10, 11. Hence, chronic moderate stress stimulated the production of DHEAS and reduced the corticosteroid imbalance in old monkeys.
authors.affiliation: Laboratory of Endocrinology, Institute of Medical Primatology, the Russian Academy of Medical Sciences, Sochi, Russia. ndgoncharova@mail.ru
authors.forename: N D
authors.initials: ND
authors.lastname: Goncharova
authors.forename: A A
authors.initials: AA
authors.lastname: Vengerin
authors.forename: O A
authors.initials: OA
authors.lastname: Chigarova
mesh_terms: D000302:Adrenal Cortex / Q000378:metabolism*; D000305:Adrenal Cortex Hormones / Q000378:metabolism*; D000375:Aging / Q000502:physiology*; D000704:Analysis of Variance; D000818:Animals; D053898:Biosynthetic Pathways / Q000502:physiology*; D019314:Dehydroepiandrosterone Sulfate / Q000378:metabolism*; D005260:Female; D007103:Immobilization; D007124:Immunoenzyme Techniques; D008253:Macaca mulatta / Q000378:metabolism*; D013312:Stress, Physiological / Q000502:physiology*; D013997:Time Factors
chemical_list: D000305:Adrenal Cortex Hormones; D019314:Dehydroepiandrosterone Sulfate