title: UCP2 I/D modulated change in BMI during a lifestyle modification intervention study in Japanese subjects.
abstract: OBJECTIVE
  Polymorphisms in uncoupling protein (UCP) genes have been strongly associated with energy expenditure and obesity. This study aimed at investigating the effects of UCP gene polymorphisms (UCP1 -3826A/G, UCP2A/V, UCP2 I/D, and UCP3 -55C/T) on change in body mass index (BMI) during a lifestyle modification program in Japanese subjects.
  
  
  RESULTS
  Intervention induced a significant decrease in energy intake (-8.6% ± 17.0%) and a significant increase in energy expenditure (7.7% ± 7.4%). As a result, participants experienced a significant decrease in their BMI of -1.8% ± 2.7%. In a multivariate regression analysis, only UCP2 D/I among the selected UCP gene polymorphisms was associated with a change in BMI independent of the effects of gender, age, baseline BMI, changes in energy intake, and expenditure. Further regression analysis revealed that, in contrast to the DD genotype group, the DI+II genotype group showed no significant association between weight loss and change in energy expenditure suggesting this polymorphism altered the effects of this parameter on change in BMI.
  
  
  CONCLUSIONS
  The study found UCP2 D/I to be associated with change in BMI by altering the effect of change in energy expenditure on change in BMI.
authors.affiliation: Department of Environmental & Preventive Medicine, Faculty of Medicine, Shimane University School of Medicine, Izumo, Japan.
authors.forename: P B
authors.initials: PB
authors.lastname: Mutombo
authors.forename: Masayuki
authors.initials: M
authors.lastname: Yamasaki
authors.forename: Kuninori
authors.initials: K
authors.lastname: Shiwaku
mesh_terms: D000368:Aged; D044466:Asian People; D001823:Body Composition / Q000235:genetics; D015992:Body Mass Index; D002149:Energy Intake / Q000235:genetics; D004734:Energy Metabolism / Q000235:genetics; D005260:Female; D005838:Genotype; D006801:Humans; D007473:Ion Channels / Q000235:genetics*; D008019:Life Style; D008297:Male; D008875:Middle Aged; D024101:Mitochondrial Proteins / Q000235:genetics*; D009765:Obesity / Q000208:ethnology / Q000235:genetics; D012044:Regression Analysis; D000071246:Uncoupling Protein 2
chemical_list: D007473:Ion Channels; D024101:Mitochondrial Proteins; C000604389:UCP2 protein, human; D000071246:Uncoupling Protein 2