title: Phosphoinositides in insulin action and diabetes.
abstract: Phosphoinositides play an essential role in insulin signaling, serving as a localization signal for a variety of proteins that participate in the regulation of cellular growth and metabolism. This chapter will examine the regulation and localization of phosphoinositide species, and will explore the roles of these lipids in insulin action. We will also discuss the changes in phosphoinositide metabolism that occur in various pathophysiological states such as insulin resistance and diabetes.
authors.affiliation: Life Sciences Institute, University of Michigan, Ann Arbor, MI 48109, USA.
authors.forename: Dave
authors.initials: D
authors.lastname: Bridges
authors.forename: Alan R
authors.initials: AR
authors.lastname: Saltiel
mesh_terms: D000818:Animals; D003920:Diabetes Mellitus / Q000378:metabolism*; D051275:Glucose Transporter Type 4 / Q000502:physiology; D006801:Humans; D007328:Insulin / Q000502:physiology*; D007333:Insulin Resistance; D000076222:Mechanistic Target of Rapamycin Complex 1; D046912:Multiprotein Complexes / Q000502:physiology; D010716:Phosphatidylinositols / Q000502:physiology*; D051057:Proto-Oncogene Proteins c-akt / Q000502:physiology; D015398:Signal Transduction / Q000502:physiology; D058570:TOR Serine-Threonine Kinases / Q000502:physiology
chemical_list: D051275:Glucose Transporter Type 4; D007328:Insulin; D046912:Multiprotein Complexes; D010716:Phosphatidylinositols; D000076222:Mechanistic Target of Rapamycin Complex 1; D051057:Proto-Oncogene Proteins c-akt; D058570:TOR Serine-Threonine Kinases