title: A comparison of preoperative ondansetron and dexamethasone in the prevention of post-tympanoplasty nausea and vomiting.
abstract: BACKGROUND
  Nausea and vomiting are common complications of anesthesia and surgery. Patients undergoing tympanoplasty are exposed to a higher risk of postoperative nausea vomiting (PONV). These complications may alter the results of reconstruction and anatomical alignments. Numerous antiemetics have been studied to prevent and treat PONV in patients undergoing tympanoplasty. The aim of this study was to compare the effect of intravenous ondansetron and dexamethasone on post-tympanoplasty PONV.
  
  
  METHODS
  In a double-blind randomized controlled clinical trial, 219 patients were divided into three groups including one receiving ondansetron, one receiving dexamethazone, and one receiving distilled water. All patients were subjected to tympanoplasty type I. The patients in the first group received ondansetron (4 mg IV), second group received oexamethasone (8 mg IV), and third group received distilled water prior to induction of anesthesia. Using Bellivelle(')s scoring system, the incidence of PONV and its severity during the 24-hour period after surgery were measured and compared.
  
  
  RESULTS
  There was no significant difference among PONV in the three groups in the first two hours after the surgery. However, in 2-8, 8-16 and 16-24 hours after the surgery the PONV in ondansetron and dexamethasone groups were significantly lower than that in the control group.
  
  
  CONCLUSIONS
  Ondansetron and dexamethasone were more effective than placebo in controlling PONV after tympanoplasty surgeries. Moreover, dexamethasone was more effective than ondansetron in preventing PONV.
  
  
  BACKGROUND
  IRCT201106154005N4.
authors.affiliation: Department of Anesthesiology, Imam Reza Hospital, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.
authors.forename: Mahmoud
authors.initials: M
authors.lastname: Eidi
authors.forename: Khosro
authors.initials: K
authors.lastname: Kolahdouzan
authors.forename: Hamzeh
authors.initials: H
authors.lastname: Hosseinzadeh
authors.forename: Razieh
authors.initials: R
authors.lastname: Tabaqi
keywords: Dexamethasone; Ondansetron; Postoperative; tympanoplasty; vomiting