title: Complement, oxidants, and endothelial injury: how a bedside observation opened a door to vascular biology.
abstract: A single encounter with a dialysis patient led to the study of complement and neutrophil aggregation, which in turn spawned our work and the remarkable development of the field of vascular biology. As our understanding of these cellular interactions and the signaling pathways involved in these processes has expanded, so has our appreciation for the broad impact of this work on an array of human diseases.
authors.affiliation: Department of Medicine, University of Minnesota, Minneapolis, Minnesota 55455, USA. verce001@umn.edu
authors.forename: Gregory M
authors.initials: GM
authors.lastname: Vercellotti
authors.forename: Charles F
authors.initials: CF
authors.lastname: Moldow
authors.forename: Harry S
authors.initials: HS
authors.lastname: Jacob
mesh_terms: D055371:Acute Lung Injury / Q000209:etiology / Q000276:immunology; D003167:Complement Activation; D003165:Complement System Proteins / Q000266:history / Q000378:metabolism* / Q000502:physiology; D003956:Dialysis / Q000009:adverse effects / Q000266:history; D004727:Endothelium / Q000276:immunology / Q000473:pathology; D049673:History, 20th Century; D006801:Humans; D008168:Lung / Q000098:blood supply / Q000276:immunology / Q000473:pathology; D018375:Neutrophil Activation; D009504:Neutrophils / Q000276:immunology / Q000378:metabolism* / Q000502:physiology; D016877:Oxidants / Q000378:metabolism*
chemical_list: D016877:Oxidants; D003165:Complement System Proteins