title: New normal values not related to age and sex, of glomerular filtration rate by (99m)Tc-DTPA renal  dynamic imaging, for the evaluation of living kidney graft donors.
abstract: The aim of this study was to investigate the normal values of glomerular filtration rate (GFR) by technetium-99m diaethylene-triamine-pentaacetic acid ((99m)Tc-DTPA) renal dynamic imaging for living kidney graft donors. In a total of 212 candidate donors, GFR was examined using (99m)Tc-DTPA renal dynamic imaging. Donors with GFR≥80mL/(min×1.73m(2)) and as low as with GFR≥70mL/(min×1.73m(2)) but a normal endogenous creatinine clearance rate (CCr) were quantified for living kidney donation. Differences in GFR levels based on sex and age were analyzed using rank correlation coefficient. Out of the 212 candidates, 161 were finally selected as kidney graft donors. The double kidney total GFR between the male and female donor groups, the GFR levels among differently-aged donor groups, and the GFR levels between the elderly (>55 years) and young- and middle-aged (≤55 years) donor groups did not show any significant difference (P>0.05). After kidney donation, renal function measured by blood urea nitrogen (BUN) and serum creatinine of all donors returned to normal within one week, and no serious complications were noticed. In conclusion, renal dynamic imaging by (99m)Tc-DTPA had a good accuracy and repeatability in GFR evaluation for living kidney donors. Candidate donors with GFR between 70mL/(min×1.73m(2)) and 80mL/(min×1.73m(2)) can be selected as kidney donors after strict screening. In living kidney donors GFR is not significantly correlated with age or sex.
authors.affiliation: Department of Nuclear Medicine, Jinan Military General Hospital, No. 25 Shifan Road Tianqiao District, Jinan 250031, China.
authors.forename: Xiuyi
authors.initials: X
authors.lastname: Zhao
authors.forename: Yahui
authors.initials: Y
authors.lastname: Shao
authors.forename: Yanming
authors.initials: Y
authors.lastname: Wang
authors.forename: Jun
authors.initials: J
authors.lastname: Tian
authors.forename: Ben
authors.initials: B
authors.lastname: Sun
authors.forename: Yanhui
authors.initials: Y
authors.lastname: Ru
authors.forename: Aimin
authors.initials: A
authors.lastname: Zhang
authors.forename: Junwen
authors.initials: J
authors.lastname: Hao
mesh_terms: D000328:Adult; D017677:Age Distribution; D002681:China / Q000453:epidemiology; D005260:Female; D005919:Glomerular Filtration Rate; D006801:Humans; D016030:Kidney Transplantation / Q000000981:diagnostic imaging* / Q000706:statistics & numerical data*; D019520:Living Donors / Q000706:statistics & numerical data*; D008297:Male; D008875:Middle Aged; D049268:Positron-Emission Tomography / Q000379:methods*; D011866:Radioisotope Renography / Q000379:methods*; D019275:Radiopharmaceuticals; D012016:Reference Values; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D017678:Sex Distribution; D016284:Technetium Tc 99m Pentetate; D055815:Young Adult
chemical_list: D019275:Radiopharmaceuticals; D016284:Technetium Tc 99m Pentetate