title: Clinical Inquiry: Can calcium supplements cause serious adverse effects in healthy people?
abstract: Yes, according to studies with some limitations.  Calcium supplements with or without vitamin D increase the risk of myocardial infarction, with numbers needed to harm (NNH) over 5 years of 69 to 240 (strength of recommendation: B, meta-analyses of randomized controlled trials that evaluated a predominantly older female population and were limited by study designs).
authors.affiliation: Hendersonville Family Practice Residency Program, Mountain Area Health Education Center, Hendersonville, NC, USA. vijayzawar@yahoo.com
authors.forename: Hayam K
authors.initials: HK
authors.lastname: Shaker
authors.forename: Sue
authors.initials: S
authors.lastname: Stigleman
mesh_terms: D000328:Adult; D000368:Aged; D002118:Calcium / Q000009:adverse effects*; D019587:Dietary Supplements / Q000009:adverse effects*; D019317:Evidence-Based Medicine; D005260:Female; D006801:Humans; D007669:Kidney Calculi / Q000139:chemically induced; D008875:Middle Aged; D009203:Myocardial Infarction / Q000139:chemically induced; D020521:Stroke / Q000139:chemically induced
chemical_list: D002118:Calcium