title: Transfusion of neocytes concentrate/pooled neocytes in β-thalassemic patients.
abstract: OBJECTIVE
  Study was aimed to observe benefits of transfusion of neocytes/pooled neocytes over packed RBCs by super transfusion regimen in β-thalassemic patients and its comparison with related studies.
  
  
  METHODS
  Twelve cases were selected and were equally divided into control and study group in which packed RBCs and neocytes were transfused respectively for one year. In study group, average 8 transfusions were required over 14 in control group.
  
  
  RESULTS
  A marked extension of transfusion interval was observed in study group patients receiving neocytes transfusion (avg. 45.8 days; range, 32-54) over control group patients i.e. those receiving conventional packed RBCs (avg. 26.1; range 22-30). There is an average 40.8% reduction in the volume of RBCs required in the study group compared to control group and this difference is statistically significant (p = 0.00075). In study group, 20.1% reduction in iron overload and increase of iron by 9.6% in control group was reported.
  
  
  CONCLUSIONS
  We observed that neocytes transfusion is effective in extending the transfusion interval as well as in reducing the blood requirement and iron over load.
authors.affiliation: Department of Pathology, G. R. Medical College, Gwalior.(M.P.), India.
authors.forename: Dharmesh Chandra
authors.initials: DC
authors.lastname: Sharma
authors.forename: Sunita
authors.initials: S
authors.lastname: Rai
authors.forename: Navneet
authors.initials: N
authors.lastname: Agarwal
authors.forename: Satya
authors.initials: S
authors.lastname: Sao
authors.forename: Ajay
authors.initials: A
authors.lastname: Gaur
authors.forename: Rahul
authors.initials: R
authors.lastname: Sapra
keywords: Iron overload; Neocytes; Pooled Neocytes; Super transfusion regimen; Thalassemia