title: Association between total bilirubin and hemoglobin A1c in Korean type 2 diabetic patients.
abstract: Recent studies have shown that bilirubin is negatively associated with hemoglobin A1c (HbA1c) in the general population. The association between bilirubin and HbA1c in serum of diabetes patients has not yet been studied. The aim of the present study was to evaluate the association between total bilirubin and HbA1c in Korean patients with type 2 diabetes. A total of 690 of the 1,275 type 2 diabetes patients registered with the public health centers in Seo-gu, Gwangju and Gokseong-gun, Jeollanam-do participated in this study. Following an overnight fast, venous blood and urine samples were collected and analyzed. The mean HbA1c values differed significantly according to total bilirubin (≤ 0.4 mg/dL, 7.6%; 0.5 mg/dL, 7.3%; 0.6-0.7 mg/dL, 7.2%; and ≥ 0.8 mg/dL, 7.1%; P for trend = 0.016) after we adjusted for other confounding factors. When the odds ratio (OR) was adjusted for other confounding factors, there was a significant association between total bilirubin and HbA1c (OR, 0.4 [95% confidence interval, 0.2-0.8] for total bilirubin ≥ 0.8 mg/dL versus ≤ 0.4 mg/dL. In conclusion, total bilirubin concentrations in serum are negatively associated with HbA1c levels after adjustment for sex, age, and other confounding factors in type 2 diabetes patients.
authors.affiliation: Department of Preventive Medicine, Chosun University Medical School, Gwangju, Korea.
authors.forename: Seong-Woo
authors.initials: SW
authors.lastname: Choi
authors.forename: Young-Hoon
authors.initials: YH
authors.lastname: Lee
authors.forename: Sun-Seog
authors.initials: SS
authors.lastname: Kweon
authors.forename: Hye-Rim
authors.initials: HR
authors.lastname: Song
authors.forename: Hye-Ran
authors.initials: HR
authors.lastname: Ahn
authors.forename: Jung-Ae
authors.initials: JA
authors.lastname: Rhee
authors.forename: Jin-Su
authors.initials: JS
authors.lastname: Choi
authors.forename: Min-Ho
authors.initials: MH
authors.lastname: Shin
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D044466:Asian People; D001663:Bilirubin / Q000032:analysis* / Q000097:blood / Q000652:urine; D003924:Diabetes Mellitus, Type 2 / Q000097:blood* / Q000175:diagnosis; D005260:Female; D006442:Glycated Hemoglobin / Q000032:analysis* / Q000652:urine; D006801:Humans; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D056910:Republic of Korea; D012307:Risk Factors
chemical_list: D001663:Bilirubin; D006442:Glycated Hemoglobin
keywords: Bilirubin; Diabetes Mellitus Type II; Glycosylated; Hemoglobin A