title: Doxorubicin loaded magneto-niosomes for targeted drug delivery.
abstract: In chemotherapy the magnetic drug targeting to a specific organ or tissue is proposed on the assumption that magnetic fields are harmless to biological systems. In this light we have vehiculated doxorubicin as model drug by novel magneto-niosomes in order to evaluate the physico-chemical properties of the obtained formulations and the in vitro release profile. Tween 60 and Pluronic L64 have been used as surfactants and the formulation cytotoxicity has been performed by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolum bromide and trypan blue dye esclusion tests. Results show that niosome dimensions and doxorubicin entrapment efficiencies are influenced by bilayer composition. In addition, formulations are able to control the deliver and release of the drug active form in a retarded manner. No additional toxicity, due to the encapsulation of ferrofluid into niosomes core, has been detected.
authors.affiliation: Department of Pharmaceutical Sciences, University of Calabria, Ed. Polifunzionale, 87030 Rende, Italy.
authors.forename: Lorena
authors.initials: L
authors.lastname: Tavano
authors.forename: Marco
authors.initials: M
authors.lastname: Vivacqua
authors.forename: Valentina
authors.initials: V
authors.lastname: Carito
authors.forename: Rita
authors.initials: R
authors.lastname: Muzzalupo
authors.forename: Maria Cristina
authors.initials: MC
authors.lastname: Caroleo
authors.forename: Fiore
authors.initials: F
authors.lastname: Nicoletta
mesh_terms: D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D004317:Doxorubicin / Q000008:administration & dosage / Q000737:chemistry*; D004337:Drug Carriers / Q000009:adverse effects / Q000737:chemistry; D016503:Drug Delivery Systems; D006801:Humans; D008081:Liposomes / Q000737:chemistry*; D046529:Microscopy, Electron, Transmission; D020442:Poloxamer / Q000737:chemistry; D011136:Polysorbates / Q000737:chemistry; D013501:Surface-Active Agents / Q000737:chemistry
chemical_list: D004337:Drug Carriers; D008081:Liposomes; D011136:Polysorbates; D013501:Surface-Active Agents; D020442:Poloxamer; D004317:Doxorubicin; C514452:pluronic L64