title: FOXA1 and breast cancer risk.
abstract: Many SNPs associated with human disease are located in non-coding regions of the genome. A new study shows that SNPs associated with breast cancer risk are located in enhancer regions and alter binding affinity for the pioneer factor FOXA1.
authors.affiliation: Cancer Research UK, Cambridge, UK.
authors.forename: Kerstin B
authors.initials: KB
authors.lastname: Meyer
authors.forename: Jason S
authors.initials: JS
authors.lastname: Carroll
mesh_terms: D051017:Apoptosis Regulatory Proteins; D001943:Breast Neoplasms / Q000235:genetics*; D002843:Chromatin / Q000235:genetics*; D005260:Female; D051541:Hepatocyte Nuclear Factor 3-alpha / Q000235:genetics*; D006609:High Mobility Group Proteins; D006801:Humans; D011980:Receptors, Progesterone / Q000235:genetics*; D015534:Trans-Activators
chemical_list: D051017:Apoptosis Regulatory Proteins; D002843:Chromatin; C496499:FOXA1 protein, human; D051541:Hepatocyte Nuclear Factor 3-alpha; D006609:High Mobility Group Proteins; D011980:Receptors, Progesterone; C521752:TOX3 protein, human; D015534:Trans-Activators