title: Molecular biology and immunology of fungal allergens.
abstract: Fungi are non-chlorophyllus microorganisms, which constitutes the main source of outdoor and indoor allergens. The antigens present in the spores and fragments of hyphae induce allergic responses in sensitized patients. The frequently recognized fungi associated with asthma include Alternaria, Cladosporium, Aspergillus, and Penicillium. With the advent of molecular biology techniques a number of fungal genes encoding relevant allergens have been cloned and the expressed allergens purified and characterized. In this review, we have presented the recent developments, where recombinant allergens have been used in the precise diagnosis of fungal allergy. We have also discussed the role played by these allergens and the T- and B-cell epitopes in the immune mechanism in fungal allergy.
authors.affiliation: Department of Pediatrics, Medical College of Wisconsin, and Research Service, Allergy-Immunology Division, VA Medical Center, 5000 West National Avenue Milwaukee, WI, 151-1, 53295 Milwaukee, Wisconsin USA.
authors.forename: V P
authors.initials: VP
authors.lastname: Kurup
authors.forename: B
authors.initials: B
authors.lastname: Banerjee
authors.forename: K J
authors.initials: KJ
authors.lastname: Kelly
authors.forename: J N
authors.initials: JN
authors.lastname: Fink
keywords: Allergens; Epitopes; Fungal allergy; Immunoassays