title: Computational cardiology: how computer simulations could be used to develop new therapies and advance existing ones.
abstract: This article reviews the latest developments in computational cardiology. It focuses on the contribution of cardiac modelling to the development of new therapies as well as the advancement of existing ones for cardiac arrhythmias and pump dysfunction. Reviewed are cardiac modelling efforts aimed at advancing and optimizing existent therapies for cardiac disease (defibrillation, ablation of ventricular tachycardia, and cardiac resynchronization therapy) and at suggesting novel treatments, including novel molecular targets, as well as efforts to use cardiac models in stratification of patients likely to benefit from a given therapy, and the use of models in diagnostic procedures.
authors.affiliation: Department of Biomedical Engineering, Institute for Computational Medicine, Johns Hopkins University, Baltimore, MD 21218, USA. ntrayanova@jhu.edu
authors.forename: Natalia A
authors.initials: NA
authors.lastname: Trayanova
authors.forename: Thomas
authors.initials: T
authors.lastname: O'Hara
authors.forename: Jason D
authors.initials: JD
authors.lastname: Bayer
authors.forename: Patrick M
authors.initials: PM
authors.lastname: Boyle
authors.forename: Kathleen S
authors.initials: KS
authors.lastname: McDowell
authors.forename: Jason
authors.initials: J
authors.lastname: Constantino
authors.forename: Hermenegild J
authors.initials: HJ
authors.lastname: Arevalo
authors.forename: Yuxuan
authors.initials: Y
authors.lastname: Hu
authors.forename: Fijoy
authors.initials: F
authors.lastname: Vadakkumpadan
mesh_terms: D000818:Animals; D001145:Arrhythmias, Cardiac / Q000175:diagnosis / Q000503:physiopathology* / Q000628:therapy*; D002309:Cardiology / Q000639:trends; D019295:Computational Biology / Q000639:trends; D003198:Computer Simulation; D005544:Forecasting; D006801:Humans; D008955:Models, Cardiovascular; D013813:Therapy, Computer-Assisted / Q000379:methods* / Q000639:trends*