title: Danger-associated molecular patterns (DAMPs) in acute lung injury.
abstract: Danger-associated molecular patterns (DAMPs) are host-derived molecules that can function to regulate the activation of pathogen recognition receptors (PRRs). These molecules play a critical role in modulating the lung injury response. DAMPs originate from multiple sources, including injured and dying cells, the extracellular matrix, or exist as immunomodulatory proteins within the airspace and interstitium. DAMPs can function as either toll-like receptor (TLR) agonists or antagonists, and can modulate both TLR and nod-like receptor (NLR) signalling cascades. Collectively, this diverse group of molecules may represent important therapeutic targets in the prevention and/or treatment of acute lung injury (ALI) and its more severe form, acute respiratory distress syndrome (ARDS).
authors.affiliation: Department of Internal Medicine, University of Michigan Medical Center, Ann Arbor, MI, USA.
authors.forename: Leslie B
authors.initials: LB
authors.lastname: Tolle
authors.forename: Theodore J
authors.initials: TJ
authors.lastname: Standiford
mesh_terms: D055371:Acute Lung Injury / Q000276:immunology / Q000378:metabolism* / Q000473:pathology; D000818:Animals; D005109:Extracellular Matrix / Q000378:metabolism / Q000473:pathology; D006801:Humans; D008024:Ligands; D008168:Lung / Q000276:immunology / Q000378:metabolism* / Q000473:pathology; D037661:Pulmonary Surfactant-Associated Proteins / Q000378:metabolism; D011971:Receptors, Immunologic / Q000378:metabolism*; D015398:Signal Transduction; D013312:Stress, Physiological; D051193:Toll-Like Receptors / Q000378:metabolism
chemical_list: D008024:Ligands; D037661:Pulmonary Surfactant-Associated Proteins; D011971:Receptors, Immunologic; D051193:Toll-Like Receptors