title: Synovial fluid D-dimer concentration in horses with osteochondritis dissecans and osteoarthritis.
abstract: OBJECTIVE
  To assess the synovial fibrinolytic pathway activation in adult horses with developmental and degenerative arthropathies such as osteochondritis dissecans (OCD) and osteoarthritis (OA) by measuring synovial D-dimer concentrations.
  
  
  METHODS
  Prospective observational clinical study of horses admitted for OCD or OA. Synovial fluid was collected during lameness examination or prior to the surgical procedure, and D-dimer concentration and routine synovial fluid analysis were performed.
  
  
  RESULTS
  Fifty-eight horses (14 with OCD, 10 with OA and 34 controls) were included in this study. Synovial D-dimer concentrations of horses with OCD and OA were both higher when compared with controls, but were only significantly different in horses with OCD (p = 0.005). However, no statistical differences were observed when comparing synovial D-dimer concentrations from the OCD horses with the OA-affected horses (p = 0.444).
  
  
  CONCLUSIONS
  Activation of coagulation and fibrinolysis play a role in the pathophysiology of equine OCD and OA.
authors.affiliation: Servei de Cirurgia Equina, Departament de Medicina i Cirurgia Animals, Universitat Autònoma de Barcelona, Spain. Thais.Ribera@uab.cat
authors.forename: T
authors.initials: T
authors.lastname: Ribera
authors.forename: L
authors.initials: L
authors.lastname: Monreal
authors.forename: M A
authors.initials: MA
authors.lastname: Delgado
authors.forename: J
authors.initials: J
authors.lastname: Ríos
authors.forename: M
authors.initials: M
authors.lastname: Prades
mesh_terms: D000818:Animals; D015415:Biomarkers; D005260:Female; D005338:Fibrin Fibrinogen Degradation Products / Q000737:chemistry / Q000378:metabolism*; D006734:Horse Diseases / Q000378:metabolism*; D006736:Horses; D016015:Logistic Models; D008297:Male; D010003:Osteoarthritis / Q000378:metabolism / Q000662:veterinary*; D010008:Osteochondritis Dissecans / Q000378:metabolism / Q000662:veterinary*; D013582:Synovial Fluid / Q000737:chemistry*
chemical_list: D015415:Biomarkers; D005338:Fibrin Fibrinogen Degradation Products; C036309:fibrin fragment D