title: Neonatal herpes encephalitis caused by a virologically confirmed acyclovir-resistant herpes simplex virus 1 strain.
abstract: A neonate with herpes simplex virus 1 encephalitis was treated with intravenous acyclovir. During the course of therapy, the infection became intractable to the treatment and a mutation in the viral thymidine kinase gene (nucleotide G375T, amino acid Q125H) developed. This mutation was demonstrated in vitro to confer acyclovir resistance.
authors.affiliation: Department of Virology 1, National Institute of Infectious Diseases, Tokyo, Japan.
authors.forename: Satsuki
authors.initials: S
authors.lastname: Kakiuchi
authors.forename: Shigeaki
authors.initials: S
authors.lastname: Nonoyama
authors.forename: Hajime
authors.initials: H
authors.lastname: Wakamatsu
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Kogawa
authors.forename: Lixin
authors.initials: L
authors.lastname: Wang
authors.forename: Hitomi
authors.initials: H
authors.lastname: Kinoshita-Yamaguchi
authors.forename: Mutsuyo
authors.initials: M
authors.lastname: Takayama-Ito
authors.forename: Chang-Kweng
authors.initials: CK
authors.lastname: Lim
authors.forename: Naoki
authors.initials: N
authors.lastname: Inoue
authors.forename: Masashi
authors.initials: M
authors.lastname: Mizuguchi
authors.forename: Takashi
authors.initials: T
authors.lastname: Igarashi
authors.forename: Masayuki
authors.initials: M
authors.lastname: Saijo
mesh_terms: D000212:Acyclovir / Q000494:pharmacology* / Q000627:therapeutic use; D019943:Amino Acid Substitution; D000998:Antiviral Agents / Q000494:pharmacology* / Q000627:therapeutic use; D004279:DNA, Viral / Q000737:chemistry / Q000235:genetics; D024882:Drug Resistance, Viral; D020803:Encephalitis, Herpes Simplex / Q000175:diagnosis* / Q000821:virology; D006561:Herpes Simplex / Q000175:diagnosis* / Q000821:virology; D018259:Herpesvirus 1, Human / Q000187:drug effects / Q000235:genetics / Q000302:isolation & purification*; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D008826:Microbial Sensitivity Tests; D008969:Molecular Sequence Data; D020125:Mutation, Missense; D011251:Pregnancy Complications, Infectious / Q000175:diagnosis* / Q000821:virology; D017422:Sequence Analysis, DNA; D013937:Thymidine Kinase / Q000235:genetics
chemical_list: D000998:Antiviral Agents; D004279:DNA, Viral; D013937:Thymidine Kinase; D000212:Acyclovir