title: Primary hepatic cancers with multiple pathologic features in a patient with hepatitis C: report of a case.
abstract: We report a case of multiple primary hepatic cancers exhibiting different pathologic features coexisting in a patient with chronic hepatitis C. Computed tomography showed 2 tumors in segment 8, 20 mm (S8-A) and 5 mm (S8-B) in diameter, and a 10-mm tumor in segment 6 (S6). Based on the images, the S8-A lesion was diagnosed as cholangiocellular carcinoma or combined hepatocellular carcinoma and cholangiocarcinoma (combined HCC-CC). The other 2 tumors were diagnosed as HCC. The patient underwent partial resections of segments 6 and 8. We found 2 more tumors (S8-C was 6 mm in diameter and S8-D was 4 mm) in the resected segment 8 specimen. Histopathologic examination revealed that the S8-A and S8-C tumors were combined HCC-CC, the S8-B and S6 lesions were scirrhous HCC, and the S8-D tumor was an early HCC. This is a very rare case in which different hepatic cancers with multiple pathologic features coexisted.
authors.affiliation: Department of Surgery, Keio University, School of Medicine, Tokyo, Japan.
authors.forename: Go
authors.initials: G
authors.lastname: Oshima
authors.forename: Masahiro
authors.initials: M
authors.lastname: Shinoda
authors.forename: Minoru
authors.initials: M
authors.lastname: Tanabe
authors.forename: Yohei
authors.initials: Y
authors.lastname: Masugi
authors.forename: Akihisa
authors.initials: A
authors.lastname: Ueno
authors.forename: Kiminori
authors.initials: K
authors.lastname: Takano
authors.forename: Minoru
authors.initials: M
authors.lastname: Kitago
authors.forename: Osamu
authors.initials: O
authors.lastname: Itano
authors.forename: Shigeyuki
authors.initials: S
authors.lastname: Kawachi
authors.forename: Kentaro
authors.initials: K
authors.lastname: Ohara
authors.forename: Masaya
authors.initials: M
authors.lastname: Oda
authors.forename: Akihiro
authors.initials: A
authors.lastname: Tanimoto
authors.forename: Michiie
authors.initials: M
authors.lastname: Sakamaoto
authors.forename: Yuko
authors.initials: Y
authors.lastname: Kitagawa
mesh_terms: D000368:Aged; D006528:Carcinoma, Hepatocellular / Q000000981:diagnostic imaging / Q000473:pathology* / Q000821:virology; D018281:Cholangiocarcinoma / Q000000981:diagnostic imaging / Q000473:pathology* / Q000821:virology; D019698:Hepatitis C, Chronic / Q000150:complications*; D006801:Humans; D008113:Liver Neoplasms / Q000000981:diagnostic imaging / Q000473:pathology* / Q000821:virology; D008297:Male; D009378:Neoplasms, Multiple Primary / Q000000981:diagnostic imaging / Q000473:pathology* / Q000821:virology; D011859:Radiography