title: Peripheral nerve injury decreases the expression of metabolic glutamate receptor 7 in dorsal root ganglion neurons.
abstract: Group II and III metabolic glutamate receptors (mGluRs) are responsible for the glutamate-mediated postsynaptic excitation of neurons. Previous pharmacological evidences show that activation of mGluR7 could inhibit nociceptive reception. However, the distribution and expression patterns of mGluR7 after peripheral injury remain unclear. Herein we found that mGluR7 was expressed in the rat peptidergic dorsal root ganglion (DRG) neurons and large neurons, but rarely in isolectin B4 positive neurons. Sciatic nerve ligation experiment showed that mGluR7 was anterogradely transported from cell body to the peripheral site. Furthermore, after peripheral nerve injury, mGluR7 expression was down-regulated in both peptidergic and large DRG neurons. Our work suggests that mGluR7 might be involved in the regulation of pathological pain after peripheral nerve injury.
authors.affiliation: Orthopedics Department, Huzhou Central Hospital, 198 Hongqi Road, Huzhou 313000, People's Republic of China.
authors.forename: Jian-You
authors.initials: JY
authors.lastname: Li
authors.forename: Xiang
authors.initials: X
authors.lastname: Wang
authors.forename: Peng-Tian
authors.initials: PT
authors.lastname: Ji
authors.forename: Xiong-Feng
authors.initials: XF
authors.lastname: Li
authors.forename: Guo-Hua
authors.initials: GH
authors.lastname: Guan
authors.forename: Xue-Sheng
authors.initials: XS
authors.lastname: Jiang
authors.forename: Guo-Shun
authors.initials: GS
authors.lastname: Zhou
authors.forename: Feng
authors.initials: F
authors.lastname: Hua
authors.forename: Nan
authors.initials: N
authors.lastname: Wang
mesh_terms: D000818:Animals; D015536:Down-Regulation; D005727:Ganglia, Spinal / Q000378:metabolism*; D008297:Male; D009474:Neurons / Q000378:metabolism; D059348:Peripheral Nerve Injuries / Q000378:metabolism*; D051381:Rats; D017207:Rats, Sprague-Dawley; D018094:Receptors, Metabotropic Glutamate / Q000378:metabolism*; D012584:Sciatic Nerve / Q000293:injuries*
chemical_list: D018094:Receptors, Metabotropic Glutamate; C102719:metabotropic glutamate receptor 7