title: Delivery, stabilization, and spatiotemporal activation of cargo molecules in cells with positively charged nanoparticles.
abstract: Positively charged photodegradable nanoparticles that simultaneously encapsulated various compounds including small and large molecules were prepared. The nanoparticles were internalized to the cell by endocytosis and were stable within the cells for at least 4 days. The encapsulated molecules were released into the cytosol using light stimuli.
authors.affiliation: Graduate School of Pharmaceutical Sciences, The University of Tokyo, Hongo, Bunkyo-ku, Japan.
authors.forename: Shuhei
authors.initials: S
authors.lastname: Murayama
authors.forename: Taihei
authors.initials: T
authors.lastname: Nishiyama
authors.forename: Kaihei
authors.initials: K
authors.lastname: Takagi
authors.forename: Fumi
authors.initials: F
authors.lastname: Ishizuka
authors.forename: Tomofumi
authors.initials: T
authors.lastname: Santa
authors.forename: Masaru
authors.initials: M
authors.lastname: Kato
mesh_terms: D002214:Capsules; D045744:Cell Line, Tumor; D004355:Drug Stability; D004705:Endocytosis / Q000528:radiation effects; D006801:Humans; D008027:Light; D053758:Nanoparticles / Q000737:chemistry*; D013997:Time Factors
chemical_list: D002214:Capsules