title: Enhancement of myeloperoxidase activity in WBCS in oral cancer patients treated with Granulocyte Macrophage Colony Stimulating Factor (GM-CSF)-A pilot study.
abstract: In a pilot study with five oral cancer patients undergoing radiotherapy (RT) three were given Granulocyte Macrophage Colony Stimulating Factor (GM-CSF) as a protective agent to reduce the mucosal inflammation during radiotherapy. The myeloperoxidase (MPO) enzyme activity in WBC was quantitated. The three patients showed a significant increase in the MPO activity when compared with two untreated controls indicating the efficacy of GM-CSF as a protective agent. It is suggested that further detailed studies with larger number of patients would be useful.
authors.affiliation: Department of Biochemistry, Kasturba Medical College, 575 001 Mangalore.
authors.forename: N
authors.initials: N
authors.lastname: Ananth
authors.forename: G B
authors.initials: GB
authors.lastname: Balaji
authors.forename: D M
authors.initials: DM
authors.lastname: Vasudevan
authors.forename: V
authors.initials: V
authors.lastname: D'Souza
authors.forename: A V
authors.initials: AV
authors.lastname: Rao
authors.forename: D
authors.initials: D
authors.lastname: Nambiar
keywords: GM-CSF; Myleoperoxidase; Neutrophils; Radiotherapy; Superoxide radicals