title: Prevalence and risk factors associated with peripheral artery disease in elderly patients undergoing peritoneal dialysis.
abstract: BACKGROUND
  Rapid growth of the elderly peritoneal dialysis (PD) population is posing a special challenge for renal teams. Peripheral artery disease (PAD) has been reported to be an independent predictor of cardiovascular and all-cause mortality in hemodialysis patients. However, the prevalence and associated risk factors for PAD in elderly PD patients have not yet been fully investigated.
  
  
  METHODS
  A total of 69 elderly PD patients were included in the present study. PAD was defined as either an ankle-brachial index < 0.9 or a history of intermittent claudication, lower-limb amputation, foot ulcers, or gangrene. On enrollment, clinical and biochemical characteristics were collected.
  
  
  RESULTS
  The overall prevalence of PAD was 31.9%. Compared with non-PAD patients, PAD patients were significantly older and more likely to be female and have longer PD duration and lower diastolic blood pressure (P < 0.001, = 0.002, 0.018, and 0.007, respectively). Serum albumin level (P < 0.001) and residual renal Kt/V value (P < 0.001) were significantly lower, but the serum C-reactive protein level (P = 0.005) was significantly higher, in PAD patients compared with non-PAD patients. Logistic regression analysis showed that serum albumin level (odds ratio = 1.485, P = 0.040) and residual renal Kt/V value (odds ratio = 1.725, P = 0.016) were independently associated with PAD.
  
  
  CONCLUSIONS
  A high prevalence of PAD appeared among elderly PD patients in Macao. Serum albumin level and residual renal Kt/V value were independently related to PAD.
authors.affiliation: Department of Nephrology, Centro Hospitalar Conde de São Januário, Macao, China.
authors.forename: Ding-Wei
authors.initials: DW
authors.lastname: Kuang
authors.forename: Chiu-Leong
authors.initials: CL
authors.lastname: Li
authors.forename: Un-I
authors.initials: UI
authors.lastname: Kuok
authors.forename: Kin
authors.initials: K
authors.lastname: Cheung
authors.forename: Weng-In
authors.initials: WI
authors.lastname: Lio
authors.forename: Jing
authors.initials: J
authors.lastname: Xin
mesh_terms: D000368:Aged; D005260:Female; D006801:Humans; D008297:Male; D058729:Peripheral Arterial Disease / Q000453:epidemiology* / Q000209:etiology*; D010530:Peritoneal Dialysis / Q000009:adverse effects*; D015995:Prevalence; D012189:Retrospective Studies; D012307:Risk Factors
keywords: ankle-brachial index; atherosclerosis; elderly; peripheral artery disease; peritoneal dialysis