title: Oncoplastic surgery in surgical treatment of breast cancer: is the timing of adjuvant treatment affected?
abstract: BACKGROUND
  With the results of studies on the timing of adjuvant treatment, it currently appears that adjuvant treatment should be initiated as soon as possible. Breast conserving surgery and oncoplastic surgery is being used with increasing frequency. Therefore, studies about whether or not these applications delay the adjuvant treatment are needed. The aim of this study was to determine the time period needed for adjuvant chemotherapy and radiotherapy of the patients with breast cancer and to reveal associated factors related to the patient, tumor, and surgical technique.
  
  
  METHODS
  Two hundred eighty patients with breast cancer who had surgery and were given adjuvant treatments in our clinic were included in the study. Age, body mass index, concomitant diseases, smoking habits, menopausal status, neoadjuvant treatments, tumor characteristics, surgical technique, and surgical complications were recorded. The time period between surgery and initiation of chemotherapy and radiotherapy, the number of chemotherapy cycles, and the duration of chemotherapy and radiotherapy were calculated.
  
  
  RESULTS
  The numbers of patients who had modified radical mastectomy, breast conserving surgery, and oncoplastic surgery were 155 (55%), 47 (16.8%), and 78 (27.9%), respectively. The mean (SD) time period needed for chemotherapy administration was 19.5 ± 4.2 days (range, 13-41 days) and 3.9 ± 0.9 months for radiotherapy. Early wound complication of breast surgery was the only factor that delayed the adjuvant chemotherapy (P = .001).
  
  
  CONCLUSIONS
  It has been well known that the time period between surgical treatment of breast cancer and adjuvant treatment affects survival. In our study, it has been shown that the surgical techniques used in breast and axillary surgery do not delay the initiation of adjuvant treatments. The adjuvant treatments of the patients who had oncoplastic surgery and breast conserving surgery were not delayed. The cooperation between the disciplines for the initiation of adjuvant treatments is important.
authors.affiliation: Department of General Surgery, Ankara Oncology Training and Education Hospital, Ankara, Turkey.
authors.forename: Lutfi
authors.initials: L
authors.lastname: Dogan
authors.forename: Mehmet Ali
authors.initials: MA
authors.lastname: Gulcelik
authors.forename: Niyazi
authors.initials: N
authors.lastname: Karaman
authors.forename: Cihangir
authors.initials: C
authors.lastname: Ozaslan
authors.forename: Erhan
authors.initials: E
authors.lastname: Reis
mesh_terms: D000328:Adult; D000970:Antineoplastic Agents / Q000627:therapeutic use; D001943:Breast Neoplasms / Q000378:metabolism / Q000473:pathology / Q000628:therapy*; D017024:Chemotherapy, Adjuvant; D005260:Female; D006801:Humans; D008408:Mastectomy / Q000379:methods; D008875:Middle Aged; D018714:Radiotherapy, Adjuvant; D013997:Time Factors
chemical_list: D000970:Antineoplastic Agents