title: Subclinical hypothyroidism in young women with polycystic ovary syndrome: an analysis of clinical, hormonal, and metabolic parameters.
abstract: OBJECTIVE
  To analyze the relationship between selected clinical and metabolic parameters in young women with polycystic ovary syndrome (PCOS) and normal thyroid function or subclinical hypothyroidism (SCH).
  
  
  METHODS
  A cross-sectional cohort study.
  
  
  METHODS
  Tertiary care clinic.
  
  
  METHODS
  Women diagnosed with PCOS according to the Rotterdam criteria (n = 168).
  
  
  METHODS
  Clinical, hormonal, and metabolic parameters were evaluated. SCH was defined as TSH levels of 4.5-10 mIU/L.
  
  
  METHODS
  Separately, PCOS and SCH exert adverse effects on metabolic parameters; however, in conjunction their effect is unclear. This study evaluated whether SCH in women with PCOS affects clinical, hormonal, and metabolic parameters.
  
  
  RESULTS
  The mean age of the 168 women was 24 ± 5.8 years. Mean body mass index was 33.4 ± 8.2 kg/m(2). Thyroid function was normal in 149 women, and 19 had SCH. Only serum low-density lipoprotein cholesterol and PRL levels were significantly higher in the women with SCH (122.6 ± 25.6 mg/dL and 17.7 ± 7.7 ng/mL, respectively) compared with those with normal thyroid function (105.6 ± 33 mg/dL and 14 ± 10.3 ng/mL, respectively).
  
  
  CONCLUSIONS
  In young women with PCOS, SCH is associated with higher low-density lipoprotein cholesterol levels, albeit with no changes in other lipid profile parameters, insulin resistance, or phenotypic manifestations. This study adds to current evidence supporting an association between PCOS and SCH.
authors.affiliation: Department of Obstetrics and Gynecology, School of Medical Sciences, State University of Campinas, Campinas, Brazil. laguna.unicamp@gmail.com
authors.forename: Cristina Laguna
authors.initials: CL
authors.lastname: Benetti-Pinto
authors.forename: Vanessa Ribeiro Santana
authors.initials: VR
authors.lastname: Berini Piccolo
authors.forename: Heraldo Mendes
authors.initials: HM
authors.lastname: Garmes
authors.forename: Cássia Raquel
authors.initials: CR
authors.lastname: Teatin Juliato
mesh_terms: D015415:Biomarkers / Q000097:blood; D001938:Brazil / Q000453:epidemiology; D015897:Comorbidity; D005260:Female; D006801:Humans; D007037:Hypothyroidism / Q000097:blood* / Q000175:diagnosis / Q000453:epidemiology*; D008055:Lipids / Q000097:blood*; D011085:Polycystic Ovary Syndrome / Q000097:blood* / Q000175:diagnosis / Q000453:epidemiology*; D015995:Prevalence; D012307:Risk Factors; D013972:Thyrotropin / Q000097:blood*; D055815:Young Adult
chemical_list: D015415:Biomarkers; D008055:Lipids; D013972:Thyrotropin