title: Adsorption of multimeric T cell antigens on carbon nanotubes: effect on protein structure and antigen-specific T cell stimulation.
abstract: Antigen-specific activation of cytotoxic T cells can be enhanced up to three-fold more than soluble controls when using functionalized bundled carbon nanotube substrates ((b) CNTs). To overcome the denaturing effects of direct adsorption on (b) CNTs, a simple but robust method is demonstrated to stabilize the T cell stimulus on carbon nanotube substrates through non-covalent attachment of the linker neutravidin.
authors.affiliation: Department of Chemical and Biomedical Engineering, Yale University, P.O. Box 208284, New Haven, Connecticut, USA.
authors.forename: Tarek R
authors.initials: TR
authors.lastname: Fadel
authors.forename: Nan
authors.initials: N
authors.lastname: Li
authors.forename: Smith
authors.initials: S
authors.lastname: Shah
authors.forename: Michael
authors.initials: M
authors.lastname: Look
authors.forename: Lisa D
authors.initials: LD
authors.lastname: Pfefferle
authors.forename: Gary L
authors.initials: GL
authors.lastname: Haller
authors.forename: Sune
authors.initials: S
authors.lastname: Justesen
authors.forename: Corey J
authors.initials: CJ
authors.lastname: Wilson
authors.forename: Tarek M
authors.initials: TM
authors.lastname: Fahmy
mesh_terms: D000327:Adsorption; D000818:Animals; D000941:Antigens / Q000737:chemistry*; D032701:Biomimetics / Q000379:methods; D002942:Circular Dichroism; D051379:Mice; D037742:Nanotubes, Carbon / Q000737:chemistry*; D013601:T-Lymphocytes / Q000276:immunology*
chemical_list: D000941:Antigens; D037742:Nanotubes, Carbon