title: Lipid abnormalities, lipoprotein (a) and apoprotein pattern in non-dialyzed patients with chronic kidney disease.
abstract: The present study was carried out to explore the altered lipid, lipoprotein and apoprotein abnormalities along with lipoprotein (a) in chronic kidney disease patients with stage I to V which were further divided into group 1 (stage I and II), group 2 (stage III and IV) and group 3 (stage V). 50 chronic kidney disease patients with stage I to V and 20 healthy normal subjects as controls were recruited for this study. Among the various parameters tested triglyceride levels were high in group 1 and 2, whereas VLDL cholesterol, Lp (a) and apo B levels were significantly high in all the groups when compared to controls (P<0.05). However, LDL cholesterol level was significantly low in group 3 only as compared to control group (P<0.05). Apoprotein AI values also showed significant decrease in all groups as compared to controls (P<0.05). Though total cholesterol levels in group 1 and LDL levels in group 1 and 2 were higher than controls, but the values attained not statistically significant (P>0.05). In conclusion high levels of VLDL cholesterol, Lp (a), apo B and low levels of apoprotein AI as reported in this study are the major lipid disorders in the development of cardiovascular complications at all the stages in these patients.
authors.affiliation: Department of Biochemistry, Sri Venkaterswara Institute of Medical Sciences, Tirupati, 517507 Chittor, AP India  ; Department of Biochemistry, PSG Institute of Medical Sciences & Research, Peelamedu, Coimbatore, 641004 Tamilnadu India.
authors.forename: A Madhusudhana
authors.initials: AM
authors.lastname: Rao
authors.forename: A R
authors.initials: AR
authors.lastname: Bitla
authors.forename: E P
authors.initials: EP
authors.lastname: Reddy
authors.forename: V
authors.initials: V
authors.lastname: Sivakumar
authors.forename: P V L N
authors.initials: PV
authors.lastname: Srinivasa Rao
keywords: Chronic Kidney Disease; End stage renal disease; Lipid Profile; Lipoprotein Metabolism; Lp(a)