title: Severe psoriasis with positive tuberculosis test and treatment with biologic therapy: a case report.
abstract: Psoriasis and tuberculosis (TB) are 2 conditions with high prevalence in the general population, often present simultaneously in the same patient. The crucial cytokine involved in the pathogenesis of psoriasis, tumor necrosis factor alpha (TNF-alpha), also is important in defending against mycobacteria. Therefore, it is important to screen patients for a latent TB infection (LTBI) while they are undergoing treatment with TNF-alpha antagonists. We present a case of a patient with psoriasis and LTBI who underwent treatment with etanercept.
authors.affiliation: Department of Dermatology "Daniele Innocenzi," Sapienza University of Rome, Polo Pontino, Italy.
authors.forename: Nevena
authors.initials: N
authors.lastname: Skroza
authors.forename: Ilaria
authors.initials: I
authors.lastname: Proietti
authors.forename: Nicoletta
authors.initials: N
authors.lastname: Bernardini
authors.forename: Giorgio
authors.initials: G
authors.lastname: La Viola
authors.forename: Francesca
authors.initials: F
authors.lastname: Nicolucci
authors.forename: Ersilia
authors.initials: E
authors.lastname: Tolino
authors.forename: Sara
authors.initials: S
authors.lastname: Zuber
authors.forename: Concetta
authors.initials: C
authors.lastname: Potenza
mesh_terms: D000068800:Etanercept; D006801:Humans; D007074:Immunoglobulin G / Q000494:pharmacology / Q000627:therapeutic use; D007155:Immunologic Factors / Q000494:pharmacology / Q000627:therapeutic use; D055985:Latent Tuberculosis / Q000175:diagnosis*; D008297:Male; D008403:Mass Screening / Q000379:methods; D008875:Middle Aged; D011565:Psoriasis / Q000188:drug therapy* / Q000473:pathology; D018124:Receptors, Tumor Necrosis Factor / Q000627:therapeutic use; D012720:Severity of Illness Index; D014374:Tuberculin Test; D014409:Tumor Necrosis Factor-alpha / Q000037:antagonists & inhibitors* / Q000378:metabolism
chemical_list: D007074:Immunoglobulin G; D007155:Immunologic Factors; D018124:Receptors, Tumor Necrosis Factor; D014409:Tumor Necrosis Factor-alpha; D000068800:Etanercept