title: Aryl-heteroaryl derivatives as novel wake-promoting agents.
abstract: In search of a next generation molecule to the novel wake-promoting agent modafinil, a series of aryl-heteroayl-derived wakefulness enhancing agents (in rats) was developed. From this work, compound 16 was separated into its enantiomers to profile them individually.
authors.forename: Brigitte
authors.initials: B
authors.lastname: Lesur
authors.forename: Yin G
authors.initials: YG
authors.lastname: Lin
authors.forename: Val R
authors.initials: VR
authors.lastname: Marcy
authors.forename: Lisa D
authors.initials: LD
authors.lastname: Aimone
authors.forename: John
authors.initials: J
authors.lastname: Gruner
authors.forename: Edward R
authors.initials: ER
authors.lastname: Bacon
authors.forename: Sankar
authors.initials: S
authors.lastname: Chatterjee
mesh_terms: D000818:Animals; D019540:Area Under Curve; D001559:Benzhydryl Compounds / Q000138:chemical synthesis / Q000737:chemistry* / Q000493:pharmacokinetics; D000697:Central Nervous System Stimulants / Q000138:chemical synthesis / Q000737:chemistry* / Q000493:pharmacokinetics; D065607:Cytochrome P-450 Enzyme Inhibitors; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism; D006207:Half-Life; D000077408:Modafinil; D011485:Protein Binding; D051381:Rats; D013237:Stereoisomerism; D013329:Structure-Activity Relationship; D013454:Sulfoxides / Q000138:chemical synthesis / Q000737:chemistry* / Q000493:pharmacokinetics; D027981:Symporters / Q000737:chemistry / Q000378:metabolism; D013876:Thiophenes / Q000138:chemical synthesis / Q000737:chemistry* / Q000493:pharmacokinetics; D014851:Wakefulness / Q000187:drug effects
chemical_list: D001559:Benzhydryl Compounds; D000697:Central Nervous System Stimulants; D065607:Cytochrome P-450 Enzyme Inhibitors; D013454:Sulfoxides; D027981:Symporters; D013876:Thiophenes; D003577:Cytochrome P-450 Enzyme System; D000077408:Modafinil