title: Innate immune sensing of HIV-1 by dendritic cells.
abstract: HIV-1-specific antibodies and CD8(+) cytotoxic T cells are detected in most HIV-1-infected people, yet HIV-1 infection is not eradicated. Contributing to the failure to mount a sterilizing immune response may be the inability of antigen-presenting dendritic cells (DCs) to sense HIV-1 during acute infection, and thus the inability to effectively prime naive, HIV-1-specific T cells. Recent findings related to DC-expressed innate immune factors including SAMHD1, TREX1, and TRIM5 provide a molecular basis for understanding why DCs fail to adequately sense invasion by this deadly pathogen and suggest experimental approaches to improve T cell priming to HIV-1 in prophylactic vaccination protocols.
authors.affiliation: Department of Microbiology and Molecular Medicine, University of Geneva, 1211 Geneva, Switzerland. jeremy.luban@umassmed.edu
authors.forename: Jeremy
authors.initials: J
authors.lastname: Luban
mesh_terms: D000090103:Antiviral Restriction Factors; D002352:Carrier Proteins / Q000276:immunology / Q000378:metabolism; D003713:Dendritic Cells / Q000276:immunology*; D005090:Exodeoxyribonucleases / Q000276:immunology / Q000378:metabolism; D015870:Gene Expression; D015497:HIV-1 / Q000276:immunology*; D007113:Immunity, Innate; D020559:Monomeric GTP-Binding Proteins / Q000276:immunology / Q000378:metabolism; D010750:Phosphoproteins / Q000276:immunology / Q000378:metabolism; D000076106:SAM Domain and HD Domain-Containing Protein 1; D013601:T-Lymphocytes / Q000276:immunology; D000070584:Tripartite Motif Proteins; D044767:Ubiquitin-Protein Ligases
chemical_list: D000090103:Antiviral Restriction Factors; D002352:Carrier Proteins; D010750:Phosphoproteins; D000070584:Tripartite Motif Proteins; C477346:TRIM5 protein, human; D044767:Ubiquitin-Protein Ligases; D005090:Exodeoxyribonucleases; C429526:three prime repair exonuclease 1; D000076106:SAM Domain and HD Domain-Containing Protein 1; C484280:SAMHD1 protein, human; D020559:Monomeric GTP-Binding Proteins