title: [Treatment of hepatitis C infection: towards eradication of chronic virus].
abstract: Hepatitis C virus multiplies efficiently in the body and causes a chronic infection. The current treatment with pegylated interferon and ribavirin is effective only in some patients. The viral genome codes for no more than ten proteins, several of which are, however, proving to be suitable targets for small-molecular inhibitors. Two protease inhibitors have been approved for therapeutic use. Preliminary results anticipate good efficiency for the new drugs either combined with previous therapy or by using combinations of the new inhibitors.
authors.affiliation: Helsingin yliopisto, Biotekniikan instituutti.
authors.forename: Tero
authors.initials: T
authors.lastname: Ahola
authors.forename: Pasi
authors.initials: P
authors.lastname: Kaukinen
mesh_terms: D000998:Antiviral Agents / Q000627:therapeutic use*; D019698:Hepatitis C, Chronic / Q000188:drug therapy*; D006801:Humans; D000077190:Interferon alpha-2; D016898:Interferon-alpha / Q000627:therapeutic use*; D011092:Polyethylene Glycols / Q000627:therapeutic use*; D011480:Protease Inhibitors / Q000627:therapeutic use*; D011994:Recombinant Proteins / Q000627:therapeutic use; D012254:Ribavirin / Q000627:therapeutic use*
chemical_list: D000998:Antiviral Agents; D000077190:Interferon alpha-2; D016898:Interferon-alpha; D011480:Protease Inhibitors; D011994:Recombinant Proteins; D011092:Polyethylene Glycols; D012254:Ribavirin; C417083:peginterferon alfa-2b