title: Gender differences in the association of insulin resistance with metabolic risk factors among Korean adolescents: Korea National Health and Nutrition Examination Survey 2008-2010.
abstract: OBJECTIVE
  We investigated the association of insulin resistance with metabolic syndrome (MetS) and its components among Korean adolescents.
  
  
  METHODS
  We analyzed the Korea National Health and Nutrition Examination Survey (2008-2010). Adolescents aged 10-18 years without diabetes (1584 boys and 1388 girls) were evaluated. Insulin resistance was assessed by homeostasis model assessment-insulin resistance (HOMA-IR), and MetS was diagnosed according to the 2007 International Diabetes Federation criteria for adolescents.
  
  
  RESULTS
  The prevalence of MetS was 1.4% among boys and 1.7% among girls. Girls in the highest quartile of HOMA-IR were significantly more likely to have MetS compared to girls in the lower quartiles independent of survey year, age, body mass index, white blood cell count, and alanine aminotransferase [odds ratio (OR), 5.33; 95% confidence interval (CI), 1.57-18.11]. Moreover, compared to girls in the lowest quartile of HOMA-IR, girls in the highest quartile significantly exhibited large waist circumference (OR, 3.22; 95% CI, 1.01-10.35), high triglycerides (OR, 6.43; 95% CI, 2.83-14.58), and low high-density lipoprotein-cholesterol (HDL-C) (OR, 2.49; 95% CI, 1.50-4.11). However, such associations were not found among boys.
  
  
  CONCLUSIONS
  Our results suggest that insulin resistance may be independently associated with MetS, large waist circumference, high triglycerides, and low HDL-C only among girls.
authors.affiliation: College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.
authors.forename: Hyun-Ah
authors.initials: HA
authors.lastname: Kim
authors.forename: Sae-Young
authors.initials: SY
authors.lastname: Lee
authors.forename: Hyuk-Sang
authors.initials: HS
authors.lastname: Kwon
authors.forename: Seung-Hwan
authors.initials: SH
authors.lastname: Lee
authors.forename: Min Ho
authors.initials: MH
authors.lastname: Jung
authors.forename: Kyungdo
authors.initials: K
authors.lastname: Han
authors.forename: Hyeon Woo
authors.initials: HW
authors.lastname: Yim
authors.forename: Won-Chul
authors.initials: WC
authors.lastname: Lee
authors.forename: Yong-Moon
authors.initials: YM
authors.lastname: Park
mesh_terms: D000293:Adolescent; D015992:Body Mass Index; D002648:Child; D008076:Cholesterol, HDL / Q000097:blood; D003430:Cross-Sectional Studies; D015536:Down-Regulation; D005260:Female; D006306:Health Surveys; D006801:Humans; D015228:Hypertriglyceridemia / Q000453:epidemiology / Q000209:etiology; D007333:Insulin Resistance / Q000208:ethnology; D007390:International Agencies; D008297:Male; D024821:Metabolic Syndrome / Q000453:epidemiology* / Q000208:ethnology / Q000378:metabolism / Q000503:physiopathology; D017410:Practice Guidelines as Topic; D015995:Prevalence; D056910:Republic of Korea / Q000453:epidemiology; D012737:Sex Factors; D014837:Voluntary Health Agencies; D055105:Waist Circumference
chemical_list: D008076:Cholesterol, HDL