title: Reduced contrast medium in abdominal aorta CTA using a multiphasic injection technique.
abstract: OBJECTIVE
  The purpose of this study was to determine if with a multiphasic injection technique the administered amount of contrast medium for abdominal computerized tomographic angiography (CTA) can be decreased, whilst improving CT image quality.
  
  
  METHODS
  In 30 patients a multiphasic injection method was compared to the standard uniphasic contrast medium injection protocol. Fifteen patients underwent abdominal CTA with a standard uniphasic injection protocol (protocol I) receiving 100mL of a non-ionic radiopaque contrast agent (Ioversol). The second group of 15 patients underwent CTA with a multiphasic injection protocol (protocol II) receiving a total of 89 mL Ioversol. Vascular contrast enhancement and difference in enhancement uniformity were assessed quantitatively and image quality was assessed by three independent radiologists.
  
  
  RESULTS
  Quantitative assessment of the vascular contrast enhancement showed that there was no significant difference in enhancement uniformity for patients between the protocols. The image quality was rated as being good to excellent in 81.8% and 88.0% of the scans, for protocol I and protocol II, respectively. However these differences were not statistically significant.
  
  
  CONCLUSIONS
  By using a multiphasic injection technique with CTA of the abdominal aorta a reduction of 11 percent of contrast medium can be realized. Enhancement patterns are quantitatively as well as qualitatively comparable to the standard contrast medium injection protocol.
authors.affiliation: University of Twente, MIRA-Institute for Biomedical Technology and Technical Medicine P.O. Box 21 7500 AE Enschede, The Netherlands. w.h.nijhof@student.utwente.nl
authors.forename: Wouter H
authors.initials: WH
authors.lastname: Nijhof
authors.forename: Charlotte S
authors.initials: CS
authors.lastname: van der Vos
authors.forename: Bauke
authors.initials: B
authors.lastname: Anninga
authors.forename: Paulien L
authors.initials: PL
authors.lastname: Stegehuis
authors.forename: Gerrit J
authors.initials: GJ
authors.lastname: Jager
authors.forename: Matthieu J C M
authors.initials: MJ
authors.lastname: Rutten
mesh_terms: D000368:Aged; D000792:Angiography / Q000379:methods*; D001012:Aorta, Abdominal / Q000000981:diagnostic imaging*; D001027:Aortography / Q000379:methods*; D003287:Contrast Media / Q000008:administration & dosage; D005260:Female; D006801:Humans; D007269:Injections, Intra-Arterial; D008297:Male; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D014057:Tomography, X-Ray Computed / Q000379:methods*; D014283:Triiodobenzoic Acids / Q000008:administration & dosage*
chemical_list: D003287:Contrast Media; D014283:Triiodobenzoic Acids; C054871:ioversol