title: Modulation of lipid metabolism by polyphenol-rich grape skin extract improves liver steatosis and adiposity in high fat fed mice.
abstract: This study investigated the influence of polyphenol-rich grape skin extract (GSE) on adiposity and hepatic steatosis in mice fed a high fat diet (HFD) and its underlying mechanisms based on adipose and hepatic lipid metabolism. C57BL/6J mice were fed a normal diet or a HFD (20% fat, w/w) with or without GSE (0.15%, w/w) for 10 weeks. The supplementation of GSE significantly lowered body weight, fat weight, plasma free fatty acid level, and hepatic lipid accumulation compared to the HFD group. Plasma leptin level was significantly lower, while the plasma adiponectin level was higher in the GSE group than in the HFD group. GSE supplementation significantly suppressed the activities of lipogenic enzymes in both adipose and liver tissues, which was concomitant with β-oxidation activation. Furthermore, GSE reversed the HFD-induced changes of the expression of genes involved in lipogenesis and β-oxidation in the liver. These findings suggest that GSE may protect against diet-induced adiposity and hepatic steatosis by regulating mRNA expression and/or activities of enzymes that regulate lipogenesis and fatty acid oxidation in the adipose tissue and liver.
authors.affiliation: Department of Food Science and Nutrition, Kyungpook National University, Daegu, Republic of Korea.
authors.forename: Hae-Jin
authors.initials: HJ
authors.lastname: Park
authors.forename: Un Ju
authors.initials: UJ
authors.lastname: Jung
authors.forename: Mi-Kyung
authors.initials: MK
authors.lastname: Lee
authors.forename: Su-Jung
authors.initials: SJ
authors.lastname: Cho
authors.forename: Hee-Kyoung
authors.initials: HK
authors.lastname: Jung
authors.forename: Joo Heon
authors.initials: JH
authors.lastname: Hong
authors.forename: Yong Bok
authors.initials: YB
authors.lastname: Park
authors.forename: Sang Ryong
authors.initials: SR
authors.lastname: Kim
authors.forename: Sangphil
authors.initials: S
authors.lastname: Shim
authors.forename: Jieun
authors.initials: J
authors.lastname: Jung
authors.forename: Myung-Sook
authors.initials: MS
authors.lastname: Choi
mesh_terms: D052242:Adiponectin / Q000097:blood; D050154:Adiposity / Q000187:drug effects*; D000818:Animals; D001835:Body Weight; D059305:Diet, High-Fat; D019587:Dietary Supplements; D005234:Fatty Liver / Q000188:drug therapy*; D020738:Leptin / Q000097:blood; D050356:Lipid Metabolism / Q000187:drug effects*; D050155:Lipogenesis / Q000187:drug effects; D008099:Liver / Q000378:metabolism; D051379:Mice; D008810:Mice, Inbred C57BL; D010936:Plant Extracts / Q000494:pharmacology; D059808:Polyphenols / Q000494:pharmacology*; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D027843:Vitis / Q000737:chemistry*
chemical_list: D052242:Adiponectin; D020738:Leptin; D010936:Plant Extracts; D059808:Polyphenols; D012333:RNA, Messenger