title: Benign pulmonary metastasizing leiomyoma uteri. Case report and review of literature.
abstract: Benign metastasizing leiomyoma (BML) is a rare condition in middle-aged women with a history of uterine leiomyomata. It is  characterized by the proliferation of, usually multiple, smooth muscle nodules. Approximately 100 cases have been reported  in the literature, and the lungs were the most common site of metastases.  We report a case of 52-year-old obese woman (BMI 31), hospital worker, smoker, admitted to the hospital with exertional  dyspnoea, night sweats, loss of weight, and productive cough.  Hysterectomy for a uterine leiomyoma was performed 9 years earlier. In addition, a history of two episodes of superficial  vein thrombosis 3 and 2 years before admission was noted. Chest X-ray and subsequently CT chest examinations revealed  multiple, non-calcified nodules within the middle and lower parts of both lungs. Specimens obtained by transbronchial  biopsy (TBLB) and from open lung biopsy displayed benign muscle cell proliferation compatible with BML. The levels of sex  hormones were characteristic for the menopause; therefore, observation was advised. Additionally, Streptococcus  pneumoniae was cultured from bronchial washing, and bronchitis was diagnosed. Antibiotics, bronchodilators, and  mucolytics were administered, and dyspnoea and cough with expectoration were diminished. Two years later pulmonary  lesions have been stable; however, she has put on weight. Subsequently the patient has developed deep vein thrombosis  with pulmonary embolism. Anticoagulant treatment was introduced, with some improvement.
authors.affiliation: III Klinika Chorób Płuc Instytutu Gruźlicy i Chorób Płuc w Warszawie Kierownik: prof. dr n. med. K. Roszkowski-Śliż. e.radzikowska@wp.pl
authors.forename: Elżbieta
authors.initials: E
authors.lastname: Radzikowska
authors.forename: Ewa
authors.initials: E
authors.lastname: Szczepulska-Wójcik
authors.forename: Renata
authors.initials: R
authors.lastname: Langfort
authors.forename: Karina
authors.initials: K
authors.lastname: Oniszh
authors.forename: Elżbieta
authors.initials: E
authors.lastname: Wiatr
mesh_terms: D005260:Female; D006801:Humans; D007044:Hysterectomy; D018231:Leiomyomatosis / Q000473:pathology* / Q000601:surgery; D008175:Lung Neoplasms / Q000556:secondary* / Q000601:surgery; D008875:Middle Aged; D055613:Multiple Pulmonary Nodules / Q000556:secondary* / Q000601:surgery; D016896:Treatment Outcome; D014594:Uterine Neoplasms / Q000473:pathology* / Q000601:surgery