title: Cell-based interventions for therapeutic angiogenesis: review of potential cell sources.
abstract: Alternative therapies are currently being developed to treat patients with chronic limb ischemia who are unable to be revascularized in order to avoid amputation. Cell-based therapy using mononuclear cells is gaining attention as many clinical trials are currently underway. We review cell differentiation along with the different potential cell sources for use in therapeutic angiogenesis.
authors.affiliation: Interdepartmental Program in Vascular Biology and Therapeutics, Yale University School of Medicine, New Haven, CT 06520-8089, USA.
authors.forename: Robert A
authors.initials: RA
authors.lastname: Brenes
authors.forename: Mackenzie
authors.initials: M
authors.lastname: Bear
authors.forename: Caroline
authors.initials: C
authors.lastname: Jadlowiec
authors.forename: Matthew
authors.initials: M
authors.lastname: Goodwin
authors.forename: Peter
authors.initials: P
authors.lastname: Hashim
authors.forename: Clinton D
authors.initials: CD
authors.lastname: Protack
authors.forename: Kenneth R
authors.initials: KR
authors.lastname: Ziegler
authors.forename: Xin
authors.initials: X
authors.lastname: Li
authors.forename: Lynn S
authors.initials: LS
authors.lastname: Model
authors.forename: Wei
authors.initials: W
authors.lastname: Lv
authors.forename: Michael J
authors.initials: MJ
authors.lastname: Collins
authors.forename: Alan
authors.initials: A
authors.lastname: Dardik
mesh_terms: D000818:Animals; D002454:Cell Differentiation; D002908:Chronic Disease; D005121:Extremities / Q000098:blood supply*; D006801:Humans; D007511:Ischemia / Q000473:pathology / Q000503:physiopathology / Q000601:surgery*; D023821:Limb Salvage; D018919:Neovascularization, Physiologic; D012038:Regeneration; D033581:Stem Cell Transplantation; D013234:Stem Cells / Q000473:pathology*; D016896:Treatment Outcome