title: Association of subclinical atherosclerosis with lipid levels amongst antiretroviral-treated and untreated HIV-infected women in the Women's Interagency HIV study.
abstract: OBJECTIVE
  We examined serum lipids in association with carotid artery intima-media thickness (CIMT) in HIV-infected and HIV-uninfected women.
  
  
  METHODS
  In 2003-4, among 1827 Women's Interagency HIV Study participants, we measured CIMT and lipids (high-density lipoprotein cholesterol (HDL-c), low-density lipoprotein cholesterol (LDL-c), total cholesterol (TC), non-HDL-c). A subset of 520 treated HIV-infected women had pre-1997 lipid measures. We used multivariable linear regression to examine associations between lipids and CIMT.
  
  
  RESULTS
  In HIV-uninfected women, higher TC, LDL-c and non-HDL-c were associated with increased CIMT. Among HIV-infected women, associations of lipids with CIMT were observed in treated but not untreated women. Among the HIV-infected women treated in 2003-4, CIMT was associated both with lipids measured a decade earlier in infection, and with late lipid measurements.
  
  
  CONCLUSIONS
  Among HIV-infected women, hyperlipidemia is most strongly associated with subclinical atherosclerosis in treated women. Among treated women, the association appeared strongest early in the disease course.
authors.affiliation: Department of Epidemiology and Population Health, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Belfer 1306C, Bronx, NY 10461, USA.
authors.forename: Christina M
authors.initials: CM
authors.lastname: Parrinello
authors.forename: Alan L
authors.initials: AL
authors.lastname: Landay
authors.forename: Howard N
authors.initials: HN
authors.lastname: Hodis
authors.forename: Stephen J
authors.initials: SJ
authors.lastname: Gange
authors.forename: Philip J
authors.initials: PJ
authors.lastname: Norris
authors.forename: Mary
authors.initials: M
authors.lastname: Young
authors.forename: Kathryn
authors.initials: K
authors.lastname: Anastos
authors.forename: Phyllis C
authors.initials: PC
authors.lastname: Tien
authors.forename: Xiaonan
authors.initials: X
authors.lastname: Xue
authors.forename: Jason
authors.initials: J
authors.lastname: Lazar
authors.forename: Lorie
authors.initials: L
authors.lastname: Benning
authors.forename: Russell P
authors.initials: RP
authors.lastname: Tracy
authors.forename: Robert C
authors.initials: RC
authors.lastname: Kaplan
mesh_terms: D000328:Adult; D044966:Anti-Retroviral Agents / Q000627:therapeutic use*; D023241:Antiretroviral Therapy, Highly Active; D058070:Asymptomatic Diseases; D050197:Atherosclerosis / Q000097:blood* / Q000175:diagnosis / Q000208:ethnology; D015415:Biomarkers / Q000097:blood; D059168:Carotid Intima-Media Thickness; D002784:Cholesterol / Q000097:blood*; D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D018450:Disease Progression; D005260:Female; D015658:HIV Infections / Q000097:blood / Q000175:diagnosis / Q000188:drug therapy* / Q000208:ethnology; D006801:Humans; D006949:Hyperlipidemias / Q000097:blood* / Q000175:diagnosis / Q000208:ethnology; D016014:Linear Models; D008875:Middle Aged; D015999:Multivariate Analysis; D012307:Risk Factors; D013997:Time Factors; D014481:United States / Q000453:epidemiology
chemical_list: D044966:Anti-Retroviral Agents; D015415:Biomarkers; D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D002784:Cholesterol