title: Altered sequence of the ETS1 transcription factor may predispose to rheumatoid arthritis susceptibility.
abstract: OBJECTIVE
  ETS1 belongs to the ETS family of transcription factors that regulate the expression of various immune-related genes. The aim of this study was to identify whether the ETS1 single nucleotide polymorphism (SNP) rs11221332, described in Caucasian subjects, plays a role in rheumatoid arthritis (RA) susceptibility.
  
  
  METHODS
  We genotyped this polymorphism in 136 unrelated patients with RA and 147 healthy individuals with no history of autoimmune disease. Genotyping was performed with a polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) assay and the data were analysed using SPSS statistical software.
  
  
  RESULTS
  A statistically significant difference was observed in the distribution of the rs11221332 genotypes between RA patients and controls (p = 0.041). Comparing the distribution of rs11221332 alleles between the groups studied, a greater difference was found [odds ratio (OR) 1.504, 95% confidence interval (CI) 1.036-2.183; p = 0.039].
  
  
  CONCLUSIONS
  The present study revealed, for first time, the positive association of a polymorphism in the sequence of the ETS1 transcription factor with RA susceptibility. Further studies in other ethnic groups of patients are needed to confirm the results of the present genetic association study related to ETS1, a widely used transcription factor in the regulation of the expression of various genes.
authors.affiliation: Department of Obstetrics and Gynaecology, Medical School, University of Ioannina, Ioannina, Greece.
authors.forename: A
authors.initials: A
authors.lastname: Chatzikyriakidou
authors.forename: P V
authors.initials: PV
authors.lastname: Voulgari
authors.forename: I
authors.initials: I
authors.lastname: Georgiou
authors.forename: A A
authors.initials: AA
authors.lastname: Drosos
mesh_terms: D000368:Aged; D001172:Arthritis, Rheumatoid / Q000453:epidemiology / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease / Q000453:epidemiology / Q000235:genetics*; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D012150:Polymorphism, Restriction Fragment Length; D020641:Polymorphism, Single Nucleotide / Q000235:genetics; D050784:Proto-Oncogene Protein c-ets-1 / Q000235:genetics*; D044465:White People / Q000235:genetics / Q000706:statistics & numerical data
chemical_list: C494041:ETS1 protein, human; D050784:Proto-Oncogene Protein c-ets-1