title: ATP cleavage by cone tetraguanidinocalix[4]arene.
abstract: The upper rim cone tetraguanidinocalix[4]arene 1 is a highly effective catalyst of ATP hydrolysis. The catalytically most active species is the triprotonated form of the catalyst. The three protonated guanidinium groups provide the electrostatic driving force for substrate binding and activation, while the neutral guanidine most likely acts as a nucleophilic catalyst.
authors.affiliation: Dipartimento di Chimica and IMC-CNR Sezione Meccanismi di Reazione, Università La Sapienza, 00185 Roma, Italy. riccardo.salvio@uniroma1.it
authors.forename: Riccardo
authors.initials: R
authors.lastname: Salvio
authors.forename: Alessandro
authors.initials: A
authors.lastname: Casnati
authors.forename: Luigi
authors.initials: L
authors.lastname: Mandolini
authors.forename: Francesco
authors.initials: F
authors.lastname: Sansone
authors.forename: Rocco
authors.initials: R
authors.lastname: Ungaro
mesh_terms: D000244:Adenosine Diphosphate / Q000737:chemistry; D000255:Adenosine Triphosphate / Q000737:chemistry*; D047250:Calixarenes / Q000737:chemistry*; D006146:Guanidines / Q000737:chemistry*; D006868:Hydrolysis; D007700:Kinetics
chemical_list: D006146:Guanidines; D047250:Calixarenes; D000244:Adenosine Diphosphate; D000255:Adenosine Triphosphate