title: Interaction between single nucleotide polymorphism in catalase gene and catalase activity under the conditions of oxidative stress.
abstract: Catalase is an antioxidant enzyme the activity of which is crucial for the protection against damage caused by reactive oxygen species. The -262C>T polymorphism in the promoter region of catalase gene was found to be associated with altered catalase levels. In this study, peripheral blood mononuclear cells catalase activity was measured after H(2)O(2)-induced oxidative stress. C/T and T/T genotypes were associated with the decrease of catalase levels in contrast to C/C donors who had elevated catalase activity in the presence of 0.4 and 0.7 mM H(2)O(2). Genotype-dependent response of catalase activity to oxidative stress might be related to the predisposition of catalase mutant allele carriers to disorders mediated by oxidative stress.
authors.affiliation: Department of Pathophysiology, Krasnoyarsk State Medical University Named After V. F. Voino-Yasenetsky, Russian Federation Ministry for Health and Social Development, Krasnoyarsk, Russia.
authors.forename: A V
authors.initials: AV
authors.lastname: Komina
authors.forename: K A
authors.initials: KA
authors.lastname: Korostileva
authors.forename: S N
authors.initials: SN
authors.lastname: Gyrylova
authors.forename: R N
authors.initials: RN
authors.lastname: Belonogov
authors.forename: T G
authors.initials: TG
authors.lastname: Ruksha
mesh_terms: D000328:Adult; D000483:Alleles; D002374:Catalase / Q000235:genetics* / Q000378:metabolism; D005260:Female; D005838:Genotype; D006801:Humans; D007963:Leukocytes, Mononuclear / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D009154:Mutation; D018384:Oxidative Stress; D020641:Polymorphism, Single Nucleotide; D017382:Reactive Oxygen Species / Q000378:metabolism; D055815:Young Adult
chemical_list: D017382:Reactive Oxygen Species; C577219:CAT protein, human; D002374:Catalase