title: Metformin overdose: time to move on.
abstract: Does metformin-associated lactic acidosis really exist? Despite an old controversy, there is no doubt about it. But do we understand what is going on? Laboratory findings raised several hypotheses explaining the pathophysiology of this disease. The main cause could be an inhibition of either gluconeogenesis or mitochondrial respiratory chain complex I. From bench to bedside, one hypothesis is now confirmed in humans. Metformin poisoning involves, at least partially, a mitochondrial dysfunction.
authors.forename: Jean-Christophe
authors.initials: JC
authors.lastname: Orban
authors.forename: Eric
authors.initials: E
authors.lastname: Fontaine
authors.forename: Carole
authors.initials: C
authors.lastname: Ichai
mesh_terms: D001792:Blood Platelets / Q000187:drug effects* / Q000378:metabolism*; D062787:Drug Overdose / Q000378:metabolism*; D005260:Female; D006801:Humans; D008297:Male; D008687:Metformin / Q000633:toxicity*; D008928:Mitochondria / Q000187:drug effects* / Q000378:metabolism*
chemical_list: D008687:Metformin