title: Sesquiterpenoids from Curcuma wenyujin with anti-influenza viral activities.
abstract: Five sesquiterpenoids, 1α,8α-epidioxy-4α-hydroxy- 5αH-guai-7(11),9-dien- 12,8-olide. (1), 8,9-seco-4β-hydroxy-1α,5βH-7(11)-guaen-8,10-olide (2), 8α-hydroxy-1α, 4β,7βH-guai-10(15)-en- 5β,8β-endoxide(3), 7β,8α-dihydroxy-1α,4αH-guai-10(15)-en-5β,8β-endoxide(4) and 7-hydroxy-5(10),6,8-cadinatriene-4-one(5), together with seven known analogs were isolated from the rhizomes of Curcuma wenyujin. Their structures and relative configurations were determined on the basis of spectroscopic methods including 2D NMR techniques, and the structures of 1 and 2 were confirmed by single-crystal X-ray diffraction experiment. Compounds 1-10 and 12 showed significant in vitro antiviral activity against the influenza virus A with IC₅₀ values ranged from 6.80 to 39.97 μM, and SI values ranged from 6.35 to 37.25.
authors.affiliation: School of Pharmacy, Wenzhou Medical College, Wenzhou 325035, PR China. jianyd163@163.com
authors.forename: Jian-Yong
authors.initials: JY
authors.lastname: Dong
authors.forename: Xi-Yan
authors.initials: XY
authors.lastname: Ma
authors.forename: Xiao-Qin
authors.initials: XQ
authors.lastname: Cai
authors.forename: Peng-Cheng
authors.initials: PC
authors.lastname: Yan
authors.forename: Lei
authors.initials: L
authors.lastname: Yue
authors.forename: Chen
authors.initials: C
authors.lastname: Lin
authors.forename: Wei-Wei
authors.initials: WW
authors.lastname: Shao
mesh_terms: D000818:Animals; D000998:Antiviral Agents / Q000737:chemistry*; D002460:Cell Line; D030024:Curcuma / Q000737:chemistry*; D004285:Dogs; D006801:Humans; D007251:Influenza, Human / Q000188:drug therapy*; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D000081223:Polycyclic Sesquiterpenes; D012717:Sesquiterpenes / Q000737:chemistry; D045789:Sesquiterpenes, Guaiane / Q000737:chemistry
chemical_list: D000998:Antiviral Agents; D000081223:Polycyclic Sesquiterpenes; D012717:Sesquiterpenes; D045789:Sesquiterpenes, Guaiane; C508039:cadinane; C421026:guaiane