title: Neuronal activity in the dorsal hippocampus after lateral hypothalamus stimulation: effects of delta-sleep-inducing peptide.
abstract: We studied central effects of delta-sleep-inducing peptide in the mechanisms of positive emotional state formation in rats. In Wistar rats preliminary tested in an open field, the reactions of 57 neurons of the dorsal hippocampus were analyzed during lateral hypothalamus stimulation and microionophoretic application of delta-sleep-inducing peptide. It was found that the number of neurons not responding to stimulation in the lateral hypothalamus surpassed the number of sensitive neurons (63 and 37%, respectively). Hippocampal neurons in active animals were less sensitive to stimulation of the lateral hypothalamus than in passive rats (33 vs. 42%) After application of delta-sleep-inducing peptide, only 28% neurons responded to stimulation. Thus, delta-sleep-inducing peptide reduced the sensitivity of hippocampal neurons to stimulation of the lateral hypothalamus.
authors.affiliation: PK Anokhin Institute of Normal Physiology, Russian Academy of Medical Sciences, Moscow, Russia. prosto_tako5@mail.ru
authors.forename: O S
authors.initials: OS
authors.lastname: Grigorchuk
authors.forename: P E
authors.initials: PE
authors.lastname: Umriukhin
mesh_terms: D000818:Animals; D003701:Delta Sleep-Inducing Peptide / Q000008:administration & dosage / Q000494:pharmacology*; D004644:Emotions / Q000187:drug effects*; D006624:Hippocampus / Q000502:physiology*; D007031:Hypothalamus / Q000187:drug effects*; D007478:Iontophoresis; D008297:Male; D009474:Neurons / Q000187:drug effects / Q000502:physiology*; D051381:Rats; D017208:Rats, Wistar
chemical_list: D003701:Delta Sleep-Inducing Peptide