title: Recruitment of urban US women at risk for HIV infection and willingness to participate in future HIV vaccine trials.
abstract: Enrollment of US women with sufficient risk of HIV infection into HIV vaccine efficacy trials has proved challenging. A cohort of 799 HIV-negative women, aged 18-45, recruited from three US cities was enrolled to assess recruitment strategies based on geographic risk pockets, social and sexual networks and occurrence of sexual concurrency and to assess HIV seroincidence during follow-up (to be reported later). Among enrolled women, 90 % lived or engaged in risk behaviors within a local risk pocket, 64 % had a male partner who had concurrent partners and 50 % had a male partner who had been recently incarcerated. Nearly half (46 %) were recruited through peer referral. At enrollment, 86 % of women said they were willing to participate in a vaccine efficacy trial. Results indicate that participant and partner risk behaviors combined with a peer referral recruitment strategy may best identify an at-risk cohort willing to participate in future trials.
authors.affiliation: Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
authors.forename: Barbara
authors.initials: B
authors.lastname: Metch
authors.forename: Ian
authors.initials: I
authors.lastname: Frank
authors.forename: Richard
authors.initials: R
authors.lastname: Novak
authors.forename: Edith
authors.initials: E
authors.lastname: Swann
authors.forename: David
authors.initials: D
authors.lastname: Metzger
authors.forename: Cecilia
authors.initials: C
authors.lastname: Morgan
authors.forename: Debbie
authors.initials: D
authors.lastname: Lucy
authors.forename: Debora
authors.initials: D
authors.lastname: Dunbar
authors.forename: Parrie
authors.initials: P
authors.lastname: Graham
authors.forename: Tamra
authors.initials: T
authors.lastname: Madenwald
authors.forename: Gina
authors.initials: G
authors.lastname: Escamilia
authors.forename: Beryl
authors.initials: B
authors.lastname: Koblin
mesh_terms: D016915:AIDS Vaccines; D000293:Adolescent; D000328:Adult; D002641:Chicago / Q000453:epidemiology; D005240:Feasibility Studies; D005260:Female; D015658:HIV Infections / Q000453:epidemiology* / Q000517:prevention & control / Q000523:psychology; D006801:Humans; D008875:Middle Aged; D009519:New York City / Q000453:epidemiology; D010358:Patient Participation / Q000523:psychology / Q000706:statistics & numerical data*; D018579:Patient Selection; D015143:Philadelphia / Q000453:epidemiology; D011446:Prospective Studies; D012307:Risk Factors; D012309:Risk-Taking; D012725:Sexual Behavior / Q000523:psychology / Q000706:statistics & numerical data*; D012747:Sexual Partners / Q000523:psychology; D011795:Surveys and Questionnaires; D014505:Urban Population
chemical_list: D016915:AIDS Vaccines