title: Simulating radiotherapy effect in high-grade glioma by using diffusive modeling and brain atlases.
abstract: Applying diffusive models for simulating the spatiotemporal change of concentration of tumour cells is a modern application of predictive oncology. Diffusive models are used for modelling glioblastoma, the most aggressive type of glioma. This paper presents the results of applying a linear quadratic model for simulating the effects of radiotherapy on an advanced diffusive glioma model. This diffusive model takes into consideration the heterogeneous velocity of glioma in gray and white matter and the anisotropic migration of tumor cells, which is facilitated along white fibers. This work uses normal brain atlases for extracting the proportions of white and gray matter and the diffusion tensors used for anisotropy. The paper also presents the results of applying this glioma model on real clinical datasets.
authors.affiliation: Institute of Computer Science, Foundation For Research and Technology-Hellas, 700 13 Heraklion, Crete, Greece. roniotis@ics.forth.gr
authors.forename: Alexandros
authors.initials: A
authors.lastname: Roniotis
authors.forename: Kostas
authors.initials: K
authors.lastname: Marias
authors.forename: Vangelis
authors.initials: V
authors.lastname: Sakkalis
authors.forename: Georgios C
authors.initials: GC
authors.lastname: Manikis
authors.forename: Michalis
authors.initials: M
authors.lastname: Zervakis
mesh_terms: D000818:Animals; D001921:Brain / Q000473:pathology / Q000528:radiation effects; D001932:Brain Neoplasms / Q000473:pathology / Q000503:physiopathology* / Q000532:radiotherapy*; D003198:Computer Simulation; D005910:Glioma / Q000473:pathology / Q000503:physiopathology* / Q000532:radiotherapy*; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods; D008953:Models, Anatomic; D008959:Models, Neurological; D011879:Radiotherapy Dosage; D011881:Radiotherapy, Computer-Assisted / Q000379:methods*; D020266:Radiotherapy, Conformal / Q000379:methods*; D061089:Radiotherapy, Image-Guided / Q000379:methods*