title: Successful treatment of chronic eosinophilic pneumonia with anti-IgE therapy.
abstract: Anti-IgE therapy, using recombinant humanized anti-IgE antibodies, is clinically effective in patients with eosinophil-related disorders such as allergic asthma, allergic rhinitis, and chronic urticaria. Chronic eosinophilic pneumonia tends to respond promptly to systemic corticosteroid therapy, however; relapses are common following corticosteroid tapering. We treated two patients (17- and 19-yr-old males) of chronic eosinophilic pneumonia whose symptoms were cough and dyspnea on exertion. The symptoms were recurrent while tapering off corticosteroid. They were treated with anti-IgE antibody without recurrence for 2 yr and 15 months. Here, we first describe clinical experience of the 2 cases of chronic eosinophilic pneumonia.
authors.affiliation: Department of Allergy and Clinical Immunology, Ajou University School of Medicine, Suwon, Korea.
authors.forename: Yoo Seob
authors.initials: YS
authors.lastname: Shin
authors.forename: Hyun Jung
authors.initials: HJ
authors.lastname: Jin
authors.forename: Hye-Soo
authors.initials: HS
authors.lastname: Yoo
authors.forename: Eui-kyung
authors.initials: EK
authors.lastname: Hwang
authors.forename: Young Hee
authors.initials: YH
authors.lastname: Nam
authors.forename: Young-Min
authors.initials: YM
authors.lastname: Ye
authors.forename: Hae-Sim
authors.initials: HS
authors.lastname: Park
mesh_terms: D000293:Adolescent; D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D000888:Antibodies, Anti-Idiotypic / Q000627:therapeutic use*; D003371:Cough / Q000209:etiology; D004417:Dyspnea / Q000209:etiology; D006801:Humans; D008297:Male; D011657:Pulmonary Eosinophilia / Q000175:diagnosis / Q000000981:diagnostic imaging / Q000628:therapy*; D014057:Tomography, X-Ray Computed; D055815:Young Adult
chemical_list: D000305:Adrenal Cortex Hormones; D000888:Antibodies, Anti-Idiotypic; C026408:anti-IgE antibodies
keywords: Anti-IgE Therapy; Chronic Eosinophilic Pneumonia