title: Obstructive sleep apnea screening and perinatal outcomes in Korean pregnant women.
abstract: OBJECTIVE
  This study was intended to evaluate the attributable risk of obstructive sleep apnea (OSA) by a sleep questionnaire to adverse pregnancy outcomes.
  
  
  METHODS
  This was a prospective, cohort study in Korean pregnant women. Berlin questionnaire was employed for symptom-based OSA screening during the third trimester and obstetric outcome data were obtained in 276 deliveries. The relationship between symptom-based OSA and outcomes were explored using SPSS version 18.0 and stratified by obesity (BMI strata <30 and ≥30). Our primary outcome was the compound occurrence of SGA (fetal) or preeclampsia (maternal). Multivariate models were applied in controlling for potential confounders.
  
  
  RESULTS
  The overall prevalence of OSA was 32.2 % and it was significantly related with the higher maternal BMI, more body weight at delivery, and weight gain during pregnancy (p = 0.007, p = 0.003, p = 0.005, respectively). There were no significant differences in the primary outcomes according to the positivity of OSA by screening, regardless of the stratification by obesity. The cesarean delivery rate was significantly higher in the OSA positive group (36.0 vs 22.5 %, p = 0.018), but it was not significant in the each strata of obesity. In multivariate analysis, the outcomes of birth weight, preeclampsia, cesarean delivery, and small for gestational age were also not different according to the positivity of OSA.
  
  
  CONCLUSIONS
  It seems that the prevalence of OSA by a sleep questionnaire is overestimating OSA in Korean pregnant women. Polysomnography might be needed to diagnose OSA and to evaluate the relationship between OSA and the occurrence of SGA or preeclampsia.
authors.affiliation: Department of Obstetrics and Gynecology, College of Medicine, The Catholic University of Korea, 505, Banpo-dong Seocho-gu, Seoul 137-450, Korea. mongkoko@catholic.ac.kr
authors.forename: Hyun Sun
authors.initials: HS
authors.lastname: Ko
authors.forename: Moon Young
authors.initials: MY
authors.lastname: Kim
authors.forename: Yeun Hee
authors.initials: YH
authors.lastname: Kim
authors.forename: Jihyun
authors.initials: J
authors.lastname: Lee
authors.forename: Yong-Gyu
authors.initials: YG
authors.lastname: Park
authors.forename: Hee Bong
authors.initials: HB
authors.lastname: Moon
authors.forename: Ki Cheol
authors.initials: KC
authors.lastname: Kil
authors.forename: Guisera
authors.initials: G
authors.lastname: Lee
authors.forename: Sa Jin
authors.initials: SJ
authors.lastname: Kim
authors.forename: Jong Chul
authors.initials: JC
authors.lastname: Shin
mesh_terms: D000328:Adult; D001034:Apgar Score; D001724:Birth Weight; D015992:Body Mass Index; D002585:Cesarean Section / Q000706:statistics & numerical data; D015331:Cohort Studies; D016640:Diabetes, Gestational / Q000453:epidemiology; D005260:Female; D006801:Humans; D046110:Hypertension, Pregnancy-Induced / Q000453:epidemiology; D007230:Infant, Low Birth Weight; D007231:Infant, Newborn; D008875:Middle Aged; D009765:Obesity / Q000453:epidemiology; D007752:Obstetric Labor, Premature / Q000453:epidemiology; D011247:Pregnancy; D011248:Pregnancy Complications / Q000175:diagnosis* / Q000453:epidemiology; D011256:Pregnancy Outcome / Q000453:epidemiology*; D047928:Premature Birth; D011446:Prospective Studies; D056910:Republic of Korea / Q000453:epidemiology; D020181:Sleep Apnea, Obstructive / Q000175:diagnosis* / Q000453:epidemiology; D011795:Surveys and Questionnaires; D055815:Young Adult