title: Covalent cargo loading to molecular shuttles via copper-free "click chemistry".
abstract: An important prerequisite for molecular shuttle-based functional devices is the development of adequate linker chemistries to load and transport versatile cargoes. Copper-free "click chemistry" has not been applied before to covalently load cargo onto molecular shuttles propelled by biological motors such as kinesin. Due to the high biocompatibility and bioorthogonality of the strain-promoted azide-alkyne cycloaddition, this approach has pronounced advantages compared to previous methods.
authors.affiliation: Laboratory of Applied Mechanobiology, Department of Health Sciences and Technology, ETH Zürich, Wolfgang-Pauli-Strasse 10, 8093 Zürich, Switzerland.
authors.forename: Susanna M
authors.initials: SM
authors.lastname: Früh
authors.forename: Dirk
authors.initials: D
authors.lastname: Steuerwald
authors.forename: Ulrich
authors.initials: U
authors.lastname: Simon
authors.forename: Viola
authors.initials: V
authors.lastname: Vogel
mesh_terms: D000255:Adenosine Triphosphate / Q000378:metabolism; D000480:Alkynes / Q000737:chemistry; D001386:Azides / Q000737:chemistry; D001692:Biological Transport; D057930:Click Chemistry / Q000295:instrumentation / Q000379:methods*; D003300:Copper; D006868:Hydrolysis; D016547:Kinesins / Q000737:chemistry; D008422:Materials Testing / Q000379:methods; D008856:Microscopy, Fluorescence; D008870:Microtubules / Q000378:metabolism; D020409:Molecular Motor Proteins / Q000737:chemistry*
chemical_list: D000480:Alkynes; D001386:Azides; D020409:Molecular Motor Proteins; D003300:Copper; D000255:Adenosine Triphosphate; D016547:Kinesins