title: Significance of maternal screening for toxoplasmosis, rubella, cytomegalovirus and herpes simplex virus infection in cases of fetal growth restriction.
abstract: OBJECTIVE
  The objective of this study was to evaluate the significance of maternal toxoplasmosis, rubella, cytomegalovirus (CMV) and herpes simplex virus (TORCH) screening in cases of fetal growth restriction (FGR).
  
  
  METHODS
  The medical records of women carrying fetuses with FGR who underwent TORCH screening over a 10-year period were retrospectively reviewed for maternal and congenital TORCH infection. Women carrying fetuses with FGR routinely underwent serologic TORCH tests and systematic ultrasound evaluation for congenital abnormalities. If a congenital CMV infection was suspected, amniotic fluid, placenta or neonatal urine was used for CMV DNA detection by polymerase chain reaction.
  
  
  RESULTS
  In 319 patients, no cases of maternal or congenital infection with toxoplasma, rubella, or herpes simplex virus were found. Conversely, six cases (1.8%) were diagnosed with congenital CMV infection, two of which had no structural abnormalities other than FGR.
  
  
  CONCLUSIONS
  A complete maternal TORCH screening for cases of FGR appears to be unnecessary. Although a maternal CMV test can be considered, the incidence of congenital CMV infection was found to be low in FGR cases.
authors.affiliation: Department of Maternal Fetal Medicine, Osaka Medical Center and Research Institute for Maternal and Child Health, Osaka, Japan. yamaryo@mch.pref.osaka.jp
authors.forename: Ryo
authors.initials: R
authors.lastname: Yamamoto
authors.forename: Keisuke
authors.initials: K
authors.lastname: Ishii
authors.forename: Mayumi
authors.initials: M
authors.lastname: Shimada
authors.forename: Syusaku
authors.initials: S
authors.lastname: Hayashi
authors.forename: Nobuhiro
authors.initials: N
authors.lastname: Hidaka
authors.forename: Masahiro
authors.initials: M
authors.lastname: Nakayama
authors.forename: Nobuaki
authors.initials: N
authors.lastname: Mitsuda
mesh_terms: D000293:Adolescent; D000328:Adult; D003586:Cytomegalovirus Infections / Q000150:complications* / Q000151:congenital* / Q000175:diagnosis; D005260:Female; D005317:Fetal Growth Retardation / Q000382:microbiology*; D006561:Herpes Simplex / Q000151:congenital / Q000175:diagnosis; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D008403:Mass Screening; D011247:Pregnancy; D012409:Rubella / Q000151:congenital / Q000175:diagnosis; D012698:Serologic Tests; D014125:Toxoplasmosis, Congenital / Q000175:diagnosis; D055815:Young Adult