title: An apparently benign vulvar mass: possibly a rare malignancy.
abstract: BACKGROUND
  Vulvar dermatofibrosarcoma is a rare fibrous tumor of intermediate grade malignancy, with a tendency for local recurrence, and rarely metastasizes. Management should be multidisciplinary. This is a report of an apparently benign vulvar mass with delayed diagnosis of vulvar dermatofibrosarcoma.
  
  
  METHODS
  A 42-year-old woman was referred to our hospital because of a vulvar tumor lasting 16 years, although several gynecological procedures and a total laparoscopic hysterectomy had been performed two years before. During this long period the lesion did not change morphological features and remained asymptomatic. Only a benign vulvar mass was diagnosed. Then, the swelling became evident showing erythematous skin with an aspect of "peau d'orange", leading the patient to consult a specialist. A firm vulvar swelling was observed in the anterior third of right labia majora continuing with about 3 cm of cord on top, quite movable above the underlying tissue but not on the overlying tissue. A wide excision was performed. The pathological examination showed positive margins. One month later an extensive deeper excision was performed. Histology confirmed a diagnosis of dermatofibrosarcoma. Immunohistochemistry was strongly positive for CD34.
  
  
  CONCLUSIONS
  Vulvar lesions always require complete pathologic examination even in case of features of benign tumor to exclude a dermatofibrosarcoma. The role of the pathologist is essential to ensure negative microscopic margins and to avoid local recurrence.
authors.affiliation: Department of Gynaecology, Obstetrics and Reproductive Sciences, Second University of Naples, Naples, Italy. enricom.messalli@unina2.it
authors.forename: E M
authors.initials: EM
authors.lastname: Messalli
authors.forename: M L
authors.initials: ML
authors.lastname: D'Aponte
authors.forename: R
authors.initials: R
authors.lastname: Luise
authors.forename: L
authors.initials: L
authors.lastname: Rossiello
authors.forename: M
authors.initials: M
authors.lastname: Rotondi
authors.forename: P
authors.initials: P
authors.lastname: De Franciscis
mesh_terms: D000328:Adult; D018223:Dermatofibrosarcoma / Q000473:pathology*; D005260:Female; D006801:Humans; D014846:Vulvar Neoplasms / Q000473:pathology*