title: Optimisation of low-dose CT with adaptive statistical iterative reconstruction in total body examination.
abstract: OBJECTIVE
  The aim of this study was to assess the feasibility of low-dose computed tomography (CT) with the adaptive statistical iterative reconstruction (ASIR) algorithm in whole-body imaging with low tube voltage and current.
  
  
  METHODS
  Twenty-three patients underwent whole-body CT with 40% of ASIR and parameters modulated according to body mass index (BMI). All had previously undergone conventional-dose CT with 100% filtered back projection (FBP). Two radiologists jointly assessed image quality (sharpness, noise, artefacts) and diagnostic quality blinded to the scanning technique. The effective dose and image quality obtained with the ASIR protocol were compared with those obtained with the FBP algorithm.
  
  
  RESULTS
  The mean effective dose achieved with ASIR was 15.6 ± 5 mSv versus 21.8 ± 5.3 mSv with the FBP protocol (p<0.0001). Image quality was good in all low-dose CT scans, and diagnostic quality was comparable with or superior to that of conventional-dose CT.
  
  
  CONCLUSIONS
  Low-dose CT with the ASIR algorithm is feasible and ensures significant reduction in effective dose.
authors.affiliation: Department of Diagnostic and Molecular Imaging, Interventional Radiology and Radiation Therapy, Fondazione Policlinico Tor Vergata, Viale Oxford 81, 00133, Rome, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Romagnoli
authors.forename: V
authors.initials: V
authors.lastname: Funel
authors.forename: A
authors.initials: A
authors.lastname: Meschini
authors.forename: A
authors.initials: A
authors.lastname: Ricci
authors.forename: S
authors.initials: S
authors.lastname: Arduini
authors.forename: C
authors.initials: C
authors.lastname: Caramanica
authors.forename: G
authors.initials: G
authors.lastname: Simonetti
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000465:Algorithms; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008297:Male; D008875:Middle Aged; D011829:Radiation Dosage; D011856:Radiographic Image Enhancement; D014057:Tomography, X-Ray Computed; D051598:Whole Body Imaging; D055815:Young Adult