title: Seroprevalence of antibodies against Chikungunya, Dengue, and Rift Valley fever viruses after febrile illness outbreak, Madagascar.
abstract: In October 2009, two-3 months after an outbreak of a febrile disease with joint pain on the eastern coast of Madagascar, we assessed serologic markers for chikungunya virus (CHIKV), dengue virus (DENV), and Rift Valley fever virus (RVFV) in 1,244 pregnant women at 6 locations. In 2 eastern coast towns, IgG seroprevalence against CHIKV was 45% and 23%; IgM seroprevalence was 28% and 5%. IgG seroprevalence against DENV was 17% and 11%. No anti-DENV IgM was detected. At 4 locations, 450-1,300 m high, IgG seroprevalence against CHIKV was 0%-3%, suggesting CHIKV had not spread to higher inland-altitudes. Four women had IgG against RVFV, probably antibodies from a 2008 epidemic. Most (78%) women from coastal locations with CHIKV-specific IgG reported joint pain and stiffness; 21% reported no symptoms. CHIKV infection was significantly associated with high bodyweight. The outbreak was an isolated CHIKV epidemic without relevant DENV co-transmission.
authors.affiliation: Bernhard Nocht Institute for Tropical Medicine,Hamburg, Germany. schwarznorbert@bni-hamburg.de
authors.forename: Norbert G
authors.initials: NG
authors.lastname: Schwarz
authors.forename: Mirko
authors.initials: M
authors.lastname: Girmann
authors.forename: Njary
authors.initials: N
authors.lastname: Randriamampionona
authors.forename: Alexandra
authors.initials: A
authors.lastname: Bialonski
authors.forename: Deborah
authors.initials: D
authors.lastname: Maus
authors.forename: Anne Caroline
authors.initials: AC
authors.lastname: Krefis
authors.forename: Christine
authors.initials: C
authors.lastname: Njarasoa
authors.forename: Jeanne Fleury
authors.initials: JF
authors.lastname: Rajanalison
authors.forename: Herly Daniel
authors.initials: HD
authors.lastname: Ramandrisoa
authors.forename: Maurice Lucien
authors.initials: ML
authors.lastname: Randriarison
authors.forename: Jürgen
authors.initials: J
authors.lastname: May
authors.forename: Jonas
authors.initials: J
authors.lastname: Schmidt-Chanasit
authors.forename: Raphael
authors.initials: R
authors.lastname: Rakotozandrindrainy
mesh_terms: D000818:Animals; D000914:Antibodies, Viral / Q000097:blood / Q000276:immunology*; D000918:Antibody Specificity / Q000276:immunology; D002460:Cell Line; D002646:Chikungunya virus / Q000276:immunology*; D003716:Dengue Virus / Q000276:immunology*; D004196:Disease Outbreaks; D005334:Fever / Q000453:epidemiology* / Q000276:immunology* / Q000821:virology; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood / Q000276:immunology; D007075:Immunoglobulin M / Q000097:blood / Q000276:immunology; D008270:Madagascar / Q000453:epidemiology; D012296:Rift Valley fever virus / Q000276:immunology*; D016036:Seroepidemiologic Studies
chemical_list: D000914:Antibodies, Viral; D007074:Immunoglobulin G; D007075:Immunoglobulin M