title: Endometrial scratching to improve pregnancy rate in couples with unexplained subfertility: a randomized controlled trial.
abstract: OBJECTIVE
  The aim of this study was to examine the effect of endometrial scratching in women with unexplained infertility.
  
  
  METHODS
  A randomized controlled trial was conducted in Mansoura University Teaching Hospital and a private practice setting. A total of 105 couples with unexplained infertility were randomly allocated into two groups: group A comprised 54 women who underwent endometrial scratching in the luteal phase of a spontaneous menstrual cycle; and group B included 51 women who underwent a placebo procedure. The main outcome measured was cumulative clinical pregnancy rate after 6 months and miscarriage rate.
  
  
  RESULTS
  Clinical pregnancy rate was significantly higher in the women experiencing endometrial biopsy than in the control group (25.9% and 9.8%, respectively, P = 0.04). There was no significant difference in miscarriage rate between pregnant women in the endometrial injury group and pregnant women in the control group (12.5% and 16.5%, respectively, P = 0.79).
  
  
  CONCLUSIONS
  Endometrial scratching may improve clinical pregnancy rates in couples with unexplained infertility. Adequately powered studies are mandated to confirm or refute the findings.
authors.affiliation: Department of Obstetrics and Gynecology, Mansoura University, Mansoura, Egypt. ahmedfathgi@yahoo.com
authors.forename: Ahmed
authors.initials: A
authors.lastname: Gibreel
authors.forename: Ahmed
authors.initials: A
authors.lastname: Badawy
authors.forename: Waleed
authors.initials: W
authors.lastname: El-Refai
authors.forename: Noha
authors.initials: N
authors.lastname: El-Adawi
mesh_terms: D000328:Adult; D004717:Endometrium / Q000601:surgery*; D005260:Female; D006801:Humans; D007246:Infertility / Q000628:therapy*; D008297:Male; D011247:Pregnancy; D018873:Pregnancy Rate; D055815:Young Adult