title: Cellular and intracellular mechanisms involved in the cognitive impairment of cannabinoids.
abstract: Exogenous cannabinoids, such as delta9-tetrahydrocannabinol (THC), as well as the modulation of endogenous cannabinoids, affect cognitive function through the activation of cannabinoid receptors. Indeed, these compounds modulate a number of signalling pathways critically implicated in the deleterious effect of cannabinoids on learning and memory. Thus, the involvement of the mammalian target of rapamycin pathway and extracellular signal-regulated kinases, together with their consequent regulation of cellular processes such as protein translation, play a critical role in the amnesic-like effects of cannabinoids. In this study, we summarize the cellular and molecular mechanisms reported in the modulation of cognitive function by the endocannabinoid system.
authors.affiliation: Departament de Ciències Experimentals i de la Salut, Facultat de Ciències de la Salut i de la Vida, Universitat Pompeu Fabra, Barcelona, Spain.
authors.forename: Emma
authors.initials: E
authors.lastname: Puighermanal
authors.forename: Arnau
authors.initials: A
authors.lastname: Busquets-Garcia
authors.forename: Rafael
authors.initials: R
authors.lastname: Maldonado
authors.forename: Andrés
authors.initials: A
authors.lastname: Ozaita
mesh_terms: D000818:Animals; D001095:Arachidonic Acids / Q000037:antagonists & inhibitors / Q000378:metabolism; D063386:Cannabinoid Receptor Agonists / Q000378:metabolism / Q000494:pharmacology; D003071:Cognition / Q000187:drug effects; D003072:Cognition Disorders / Q000139:chemically induced* / Q000378:metabolism; D013759:Dronabinol / Q000009:adverse effects*; D063388:Endocannabinoids / Q000037:antagonists & inhibitors / Q000378:metabolism; D005989:Glycerides / Q000037:antagonists & inhibitors / Q000378:metabolism; D006624:Hippocampus / Q000378:metabolism / Q000503:physiopathology; D006801:Humans; D008568:Memory / Q000187:drug effects; D009473:Neuronal Plasticity; D053284:Polyunsaturated Alkamides / Q000037:antagonists & inhibitors / Q000378:metabolism; D043884:Receptor, Cannabinoid, CB1 / Q000378:metabolism*; D009435:Synaptic Transmission; D058570:TOR Serine-Threonine Kinases / Q000378:metabolism
chemical_list: D001095:Arachidonic Acids; D063386:Cannabinoid Receptor Agonists; D063388:Endocannabinoids; D005989:Glycerides; D053284:Polyunsaturated Alkamides; D043884:Receptor, Cannabinoid, CB1; D013759:Dronabinol; C094503:glyceryl 2-arachidonate; C546842:MTOR protein, human; D058570:TOR Serine-Threonine Kinases; C078814:anandamide