title: Implications for the mammalian sialidases in the physiopathology of skeletal muscle.
abstract: The family of mammalian sialidases is composed of four distinct versatile enzymes that remove negatively charged terminal sialic acid residues from gangliosides and glycoproteins in different subcellular areas and organelles, including lysosomes, cytosol, plasma membrane and mitochondria. In this review we summarize the growing body of data describing the important role of sialidases in skeletal muscle, a complex apparatus involved in numerous key functions and whose functional integrity can be affected by various conditions, such as aging, chronic diseases, cancer and neuromuscular disorders. In addition to supporting the proper catabolism of glycoconjugates, sialidases can affect different signaling pathways by desialylation of many receptors and modulation of ganglioside content in cell membranes, thus actively participating in myoblast proliferation, differentiation and hypertrophy, insulin responsiveness and skeletal muscle architecture.
authors.affiliation: Department of Biomedical Sciences and Biotechnologies and Interuniversitary Institute of Myology (IIM), University of Brescia, Viale Europa 11, 25123, Brescia, Italy. fanzani@med.unibs.it.
authors.forename: Alessandro
authors.initials: A
authors.lastname: Fanzani
authors.forename: Alessandra
authors.initials: A
authors.lastname: Zanola
authors.forename: Fiorella
authors.initials: F
authors.lastname: Faggi
authors.forename: Nadia
authors.initials: N
authors.lastname: Papini
authors.forename: Bruno
authors.initials: B
authors.lastname: Venerando
authors.forename: Guido
authors.initials: G
authors.lastname: Tettamanti
authors.forename: Maurilio
authors.initials: M
authors.lastname: Sampaolesi
authors.forename: Eugenio
authors.initials: E
authors.lastname: Monti