title: Acute irradiation injury of canine brain with pathology control is detected by diffusion-weighted imaging of MRI.
abstract: To investigate the pathological changes of canine brain after irradiation and evaluate the effect of diffusion-weighted imaging (DWI), 25 healthy dogs were treated with 70 Gy (60)Coγ-ray irradiation on right temporal brain. Respectively, the apparent diffusion coefficient (ADC) values of canine alba and ectocinerea were measured by MRI T1 weighted imaging (T1WI), T2 weighted imaging (T2WI), and DWI. Compared with the control group, at every time point after irradiation, the ADC values of canine brain tissue were decreased significantly (P<.05). DWI is a very sensitive imaging technology that detects the changes of water molecule diffusion and microscopic pathological changes after canine brain irradiation.
authors.affiliation: Department of Radiation Oncology, JiNan Military General Hospital, District TianQiao, 250031, JiNan, Shandong, China.
authors.forename: Yanming
authors.initials: Y
authors.lastname: Wang
authors.forename: Xiaoyan
authors.initials: X
authors.lastname: Lv
authors.forename: Hai
authors.initials: H
authors.lastname: Gong
authors.forename: Guanghui
authors.initials: G
authors.lastname: Yuan
authors.forename: Baoyi
authors.initials: B
authors.lastname: Zhang
authors.forename: Hui
authors.initials: H
authors.lastname: Zhao
authors.forename: Jianguo
authors.initials: J
authors.lastname: Liu
mesh_terms: D000208:Acute Disease; D000818:Animals; D001921:Brain / Q000473:pathology*; D001930:Brain Injuries / Q000473:pathology*; D038524:Diffusion Magnetic Resonance Imaging / Q000379:methods*; D004285:Dogs; D005260:Female; D008297:Male; D011832:Radiation Injuries / Q000473:pathology*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D013702:Temporal Lobe / Q000293:injuries* / Q000473:pathology* / Q000528:radiation effects