title: Triterpenes and steroids from the leaves of Aglaia exima (Meliaceae).
abstract: A study on the leaves of Aglaia exima led to the isolation of one new and seven known compounds: six triterpenoids and two steroids. Their structures were elucidated and analyzed mainly by using spectroscopic methods; 1D and 2D NMR, mass spectrometry, UV spectrometry and X-ray. All the triterpenoids and steroids were measured in vitro for their cytotoxic activities against eight cancer cell lines; lung (A549), prostate (DU-145), skin (SK-MEL-5), pancreatic (BxPC-3), liver (Hep G2), colon (HT-29), breast (MCF-7) and (MDA-MB-231). The new cycloartane triterpenoid, 24(E)-cycloart-24-ene-26-ol-3-one 1, showed potent cytotoxic activity against colon (HT-29) cancer cell line (IC(50) 11.5μM).
authors.affiliation: Department of Chemistry, University of Malaya, 50603 Kuala Lumpur, Malaysia. khalijah@um.edu.my
authors.forename: Khalijah
authors.initials: K
authors.lastname: Awang
authors.forename: Xe-Min
authors.initials: XM
authors.lastname: Loong
authors.forename: Kok Hoong
authors.initials: KH
authors.lastname: Leong
authors.forename: Unang
authors.initials: U
authors.lastname: Supratman
authors.forename: Marc
authors.initials: M
authors.lastname: Litaudon
authors.forename: Mat Ropi
authors.initials: MR
authors.lastname: Mukhtar
authors.forename: Khalit
authors.initials: K
authors.lastname: Mohamad
mesh_terms: D000814:Aniline Compounds / Q000737:chemistry*; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000494:pharmacology; D045744:Cell Line, Tumor; D006801:Humans; D029582:Meliaceae / Q000737:chemistry*; D015394:Molecular Structure; D013057:Spectrum Analysis; D013256:Steroids / Q000737:chemistry* / Q000494:pharmacology; D014315:Triterpenes / Q000737:chemistry* / Q000494:pharmacology
chemical_list: C581113:24(E)-cycloart-24-ene-26-ol-3-one; D000814:Aniline Compounds; D000972:Antineoplastic Agents, Phytogenic; D013256:Steroids; D014315:Triterpenes; C003499:nitralin