title: Efficient synthesis and first regioselective C-3 direct arylation of imidazo[1,2-b]pyrazoles.
abstract: Highly regioselective: An efficient synthesis of the imidazo[1,2-b]pyrazole core has been developed, and the first regioselective palladium-catalyzed direct arylation of the C-3 position is described (see scheme). Good to excellent yields were obtained for a wide range of aryl partners with electron-rich and electron-poor substituents. This methodology allows rapid access to a large variety of imidazo[1,2-b]pyrazole products and could open the way to the design of new biologically active compounds.
authors.affiliation: Institut de Chimie Organique et Analytique (ICOA), Université d'Orléans, UMR-CNRS 7311, BP 6759, rue de Chartres, 45067 Orléans cedex 2, France.
authors.forename: Sandrine
authors.initials: S
authors.lastname: Grosse
authors.forename: Christelle
authors.initials: C
authors.lastname: Pillard
authors.forename: Stéphane
authors.initials: S
authors.lastname: Massip
authors.forename: Jean Michel
authors.initials: JM
authors.lastname: Léger
authors.forename: Christian
authors.initials: C
authors.lastname: Jarry
authors.forename: Stéphane
authors.initials: S
authors.lastname: Bourg
authors.forename: Philippe
authors.initials: P
authors.lastname: Bernard
authors.forename: Gérald
authors.initials: G
authors.lastname: Guillaumet
mesh_terms: D015394:Molecular Structure; D009942:Organometallic Compounds / Q000737:chemistry; D010165:Palladium / Q000737:chemistry; D011720:Pyrazoles / Q000138:chemical synthesis* / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D009942:Organometallic Compounds; D011720:Pyrazoles; D010165:Palladium