title: [Polyneuropathy associated with monoclonal gammopathy of undetermined significance].
abstract: The prevalence of polyneuropathy in patients with monoclonal gammopathy of undetermined significance (MGUS) has been reported to be 10-50%. The majority of patients have a chronic, slowly progressive, distal, symmetric and predominantly sensory polyneuropathy. A caused relationship between polyneuropathy and immunoglobulin (Ig)M MGUS is better established than the relationship between polyneuropathy and IgG/IgA MGUS because of the observed binding of IgM to myelin sheaths and widening of myelin lamellae. In randomized controlled trials plasma exchange, immunosuppressive, rituximab and intravenous Ig have been found to have a clinical meaningful effect.
authors.affiliation: Neurologisk Afdeling, Odense Universitetshospital. mhen0085@regionh.dk
authors.forename: Marie
authors.initials: M
authors.lastname: Moth Henriksen
authors.forename: Eva Brøsted
authors.initials: EB
authors.lastname: Kolmos
authors.forename: Niels
authors.initials: N
authors.lastname: Abildgaard
authors.forename: Henrik Daa
authors.initials: HD
authors.lastname: Schrøder
authors.forename: Søren
authors.initials: S
authors.lastname: Sindrup
mesh_terms: D058846:Antibodies, Monoclonal, Murine-Derived / Q000627:therapeutic use; D019085:Fluorescent Antibody Technique, Direct; D006801:Humans; D007070:Immunoglobulin A / Q000378:metabolism; D007074:Immunoglobulin G / Q000378:metabolism; D007075:Immunoglobulin M / Q000378:metabolism; D016756:Immunoglobulins, Intravenous / Q000627:therapeutic use; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D016898:Interferon-alpha / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D008998:Monoclonal Gammopathy of Undetermined Significance / Q000150:complications / Q000453:epidemiology / Q000209:etiology / Q000628:therapy; D009186:Myelin Sheath / Q000000981:diagnostic imaging / Q000473:pathology; D009413:Nerve Fibers, Myelinated / Q000000981:diagnostic imaging / Q000473:pathology; D010951:Plasma Exchange; D011115:Polyneuropathies / Q000150:complications / Q000453:epidemiology / Q000209:etiology / Q000628:therapy; D000069283:Rituximab; D013497:Sural Nerve / Q000000981:diagnostic imaging / Q000473:pathology; D014463:Ultrasonography
chemical_list: D058846:Antibodies, Monoclonal, Murine-Derived; D007070:Immunoglobulin A; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D016756:Immunoglobulins, Intravenous; D007166:Immunosuppressive Agents; D016898:Interferon-alpha; D000069283:Rituximab