title: Antithrombotic effect of taurine in healthy Japanese people may be related to an increased endogenous thrombolytic activity.
abstract: BACKGROUND
  Prevention of arterial thrombotic diseases has high priority in developed countries. Taurine (2-aminomethylsulfonic acid), which is rich in sea foods, showed antithrombotic effect in animal models of thrombosis. The present study aimed to investigate such effect in healthy human volunteers.
  
  
  RESULTS
  In 101 healthy Japanese people the overall thrombotic status was accessed from non-anticoagulated blood sample by the Global Thrombosis Test (GTT). There was no significant correlation between taurine concentration in urine samples and GTT-Occlusion Times (OT; mainly reactivity of platelets). In contrast, a significant inverse correlation was demonstrated between urine taurine concentrations and GTT-Lysis Times (LT; showing spontaneous thrombolytic activity).
  
  
  CONCLUSIONS
  Our findings suggest that taurine enhances endogenous thrombolytic activity which could be a mechanism of the earlier observed cardioprotective and antithrombotic effect.
authors.affiliation: Department of Health and Nutrition, Faculty of Liberal Arts, Osaka Shoin Women's University, 4-2-26, Hishiyanishi, Higashiosaka 577-8550, Osaka, Japan. ijiri.yoshinobu@osaka-shoin.ac.jp
authors.forename: Yoshinobu
authors.initials: Y
authors.lastname: Ijiri
authors.forename: Hideo
authors.initials: H
authors.lastname: Ikarugi
authors.forename: Yukinori
authors.initials: Y
authors.lastname: Tamura
authors.forename: Mayumi
authors.initials: M
authors.lastname: Ura
authors.forename: Mai
authors.initials: M
authors.lastname: Morishita
authors.forename: Atsumi
authors.initials: A
authors.lastname: Hamada
authors.forename: Mari
authors.initials: M
authors.lastname: Mori
authors.forename: Hideki
authors.initials: H
authors.lastname: Mori
authors.forename: Yukio
authors.initials: Y
authors.lastname: Yamori
authors.forename: Hiromitsu
authors.initials: H
authors.lastname: Ishii
authors.forename: Junichiro
authors.initials: J
authors.lastname: Yamamoto
mesh_terms: D000328:Adult; D000368:Aged; D000925:Anticoagulants / Q000494:pharmacology*; D044466:Asian People; D001777:Blood Coagulation / Q000502:physiology*; D002318:Cardiovascular Diseases / Q000097:blood* / Q000517:prevention & control; D005260:Female; D005342:Fibrinolysis; D006801:Humans; D008297:Male; D008875:Middle Aged; D013654:Taurine / Q000494:pharmacology*; D013927:Thrombosis / Q000097:blood* / Q000208:ethnology / Q000517:prevention & control
chemical_list: D000925:Anticoagulants; D013654:Taurine