title: Heart rate and heart rate variability in panic, social anxiety, obsessive-compulsive, and generalized anxiety disorders at baseline and in response to relaxation and hyperventilation.
abstract: It remains unclear if diminished high frequency heart rate variability (HF-HRV) can be found across anxiety disorders. HF-HRV and heart rate (HR) were examined in panic (PD), generalized anxiety (GAD), social anxiety (SAD), and obsessive-compulsive disorder (OCD) relative to healthy controls at baseline and during anxiety stressors. All disorders evidenced diminished baseline HF-HRV relative to controls. Baseline HRV differences were maintained throughout relaxation. For hyperventilation, PD and GAD demonstrated greater HR than controls. Psychotropic medication did not account for HF-HRV differences except in OCD. Age and sex evidenced multiple main effects. Findings suggest that low baseline HF-HRV represents a common index for inhibitory deficits across PD, GAD, and SAD, which is consistent with the notion of autonomic inflexibility in anxiety disorders. Elevated HR responses to hyperventilation, however, are specific to PD and GAD.
authors.affiliation: Department of Psychology, School of Social Sciences, University of Mannheim, Mannheim, Germany.
authors.forename: Andre
authors.initials: A
authors.lastname: Pittig
authors.forename: Joanna J
authors.initials: JJ
authors.lastname: Arch
authors.forename: Chi W R
authors.initials: CW
authors.lastname: Lam
authors.forename: Michelle G
authors.initials: MG
authors.lastname: Craske
mesh_terms: D000328:Adult; D001008:Anxiety Disorders / Q000453:epidemiology / Q000503:physiopathology / Q000628:therapy; D005260:Female; D006339:Heart Rate / Q000502:physiology*; D006801:Humans; D006985:Hyperventilation / Q000453:epidemiology / Q000503:physiopathology* / Q000628:therapy; D008297:Male; D008875:Middle Aged; D009771:Obsessive-Compulsive Disorder / Q000453:epidemiology / Q000503:physiopathology* / Q000628:therapy; D010200:Panic / Q000502:physiology*; D010698:Phobic Disorders / Q000453:epidemiology / Q000503:physiopathology* / Q000628:therapy; D012064:Relaxation Therapy / Q000379:methods*; D016896:Treatment Outcome; D055815:Young Adult