title: Prognostic factors and outcomes of patients with pulmonary hypertension admitted to the intensive care unit.
abstract: OBJECTIVE
  Patients with pulmonary hypertension (PH) can decompensate to the point where they require care in the intensive care unit (ICU). Our objective is to examine the outcomes and characteristics of patients with PH admitted to the ICU.
  
  
  METHODS
  This is a retrospective study of 99 patients with PH who were admitted to the medical ICU of a single tertiary care center. Baseline characteristics, interventions during ICU admission, and ICU and 6-month outcome were documented. Univariate and multivariate logistic regressions were used to evaluate association of patient characteristics with mortality.
  
  
  RESULTS
  Intensive care unit mortality was 30%, and 6-month mortality was 40%. Acute Physiology and Chronic Health Evaluation II score, World Health Organization Group 3 PH, and preexisting treatment with a prostacyclin at time of ICU admission were associated with worse outcome. Patients who received cardiopulmonary resuscitation had 100% mortality. The requirement for mechanical ventilation and dialysis was also associated with increased mortality. Pulmonary artery catheter placement was associated with reduced mortality, specifically if it was placed early during ICU admission and if associated with a change in the present management.
  
  
  CONCLUSIONS
  Mortality is high in critically ill patients with PH. The identification of prognostic baseline characteristics and interventions in the ICU is important and warrants further investigation.
authors.affiliation: Division of Pulmonary and Critical Care Medicine, Department of Medicine, David Geffen School of Medicine, UCLA, BOX 951690, 37-131 CHS, Los Angeles, CA 90095-1690, USA. thuynh@mednet.ucla.edu
authors.forename: Thanh N
authors.initials: TN
authors.lastname: Huynh
authors.forename: S Sam
authors.initials: SS
authors.lastname: Weigt
authors.forename: Catherine A
authors.initials: CA
authors.lastname: Sugar
authors.forename: Shelley
authors.initials: S
authors.lastname: Shapiro
authors.forename: Eric C
authors.initials: EC
authors.lastname: Kleerup
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D016887:Cardiopulmonary Resuscitation; D003956:Dialysis / Q000706:statistics & numerical data; D005260:Female; D006305:Health Status Indicators; D017052:Hospital Mortality; D006801:Humans; D006976:Hypertension, Pulmonary / Q000401:mortality*; D007362:Intensive Care Units / Q000706:statistics & numerical data*; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D012121:Respiration, Artificial / Q000706:statistics & numerical data; D012189:Retrospective Studies; D062606:Tertiary Care Centers / Q000706:statistics & numerical data*; D016896:Treatment Outcome