title: [Effect of prostatilen AC suppositories on course of experimental prostatitis].
abstract: The article presents the results of evaluation of efficacy of new drug prostatilen AC (rectal suppositories), containing regulatory peptides of the bovine prostate and zinc arginate-glycinate complex, in the treatment of prostatitis. The experiment was conducted on 40 Sprague-Dawley rats weighing 180-200 g. Chronic prostatitis was modeled by injection of 10% Dimexidum in combination with water, mixed with turpentine, a volumetric ratio of 4:1. It is shown that prostatilen AC has pronounced organotropic antiinflammatory effect, which manifests in reducing the weight of the prostate, reducing the protein level in the urine, activity of acid phosphatase, and levels of ceruloplasmin and C-reactive protein. In addition, this drug normalizes the act of urination and increases the diurnal diuresis, has antioxidant properties and increases the blood level of the male sex hormone testosterone.
authors.forename: T N
authors.initials: TN
authors.lastname: Savateeva-Liubimova
authors.forename: K V
authors.initials: KV
authors.lastname: Sivak
authors.forename: V V
authors.initials: VV
authors.lastname: Malinin
mesh_terms: D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage* / Q000009:adverse effects; D002097:C-Reactive Protein / Q000378:metabolism; D002417:Cattle; D002570:Ceruloplasmin / Q000378:metabolism; D002908:Chronic Disease; D004195:Disease Models, Animal; D004231:Diuresis / Q000187:drug effects; D006801:Humans; D008297:Male; D009929:Organ Size / Q000187:drug effects; D010455:Peptides / Q000008:administration & dosage* / Q000009:adverse effects; D011467:Prostate / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology; D011472:Prostatitis / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology; D051381:Rats; D017207:Rats, Sprague-Dawley; D013488:Suppositories; D013739:Testosterone / Q000097:blood
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D010455:Peptides; D013488:Suppositories; C069549:prostatilen; D013739:Testosterone; D002097:C-Reactive Protein; D002570:Ceruloplasmin