title: Urinary catecholamine metabolites: Capillary gas chromatography method and experience with 12 cases of neuroblastoma.
abstract: We propose a rapid, simple metodology for routine analysis of human urine to detect vanillylmandelic and homovanillic acid related to neuroblastoma. The assay were specific capillary gas chromatography with flame ionization detection. In this methodology an internal standard is used and the procedure involves ethyl ester formation without isolation of the compounds of interest. The run time is 36 minutes. We also report quantitative results for urinary vanillylmandelic and homovanillic acid in neuroblastoma patients, demonstrating the diagnostic value of this method.
authors.affiliation: Department of Pediatrics, Mother and Child Health Care Institute of Serbia, Belgrade, Yugoslavia.
authors.forename: Sanja
authors.initials: S
authors.lastname: Grkovic
authors.forename: Rajko
authors.initials: R
authors.lastname: Nikolic
authors.forename: Maja
authors.initials: M
authors.lastname: Dordevic
authors.forename: Ljubomir
authors.initials: L
authors.lastname: Stojanov
keywords: Capillary gas chromatography; Homovanillic acid; diagnostic aids; neuroblastoma; vanillylmandelic acid