title: Effect of treatment with testosterone derivatives on morphometric characteristics and free radical oxidation in rat cerebral cortex.
abstract: Morphometric characteristics and free radical oxidation in neurons of the neocortex and hippocampus of male and female rats were studied 1 month after administration of Sustanon-250 in a dose of 8 mg/kg during the pubertal period of ontogeny. The weight of the brain was shown to decrease in males. In both female and male rats, the width of the anterior parietal lobe and the numerical density of neocortical and hippocampal neurons decreased. Sex differences were found in free radical oxidation in the cerebral cortex. The intensity of this process increased significantly in females, but decreased in males.
authors.affiliation: Department of Histology, Far-Eastern State Medical University, Khabarovsk, Russia.
authors.forename: B Ya
authors.initials: BY
authors.lastname: Ryzhavskii
authors.forename: O V
authors.initials: OV
authors.lastname: Zadvornaya
authors.forename: O A
authors.initials: OA
authors.lastname: Lebed'ko
mesh_terms: D000818:Animals; D021461:Animals, Outbred Strains; D001835:Body Weight / Q000187:drug effects; D005260:Female; D005609:Free Radicals / Q000037:antagonists & inhibitors / Q000378:metabolism; D006624:Hippocampus / Q000187:drug effects*; D007273:Injections, Intramuscular; D008297:Male; D019579:Neocortex / Q000187:drug effects*; D009474:Neurons / Q000187:drug effects*; D009929:Organ Size / Q000187:drug effects; D018384:Oxidative Stress / Q000187:drug effects; D010296:Parietal Lobe / Q000187:drug effects*; D051381:Rats; D012737:Sex Factors; D013739:Testosterone / Q000031:analogs & derivatives / Q000494:pharmacology*
chemical_list: D005609:Free Radicals; D013739:Testosterone