title: Permanent hair dye-incorporated hyaluronic acid nanoparticles.
abstract: We prepared p-phenylenediamine (PDA)-incorporated nanoparticles using hyaluronic acid (HA). PDA-incorporated HA nanoparticles have spherical shapes and sizes were less than 300 nm. The results of FT-IR spectra indicated that PDA-incorporated HA nanoparticles were formed by ion-complex formation between amine group of PDA and carboxyl group of HA. Furthermore, powder-X-ray diffractogram (XRD) measurement showed that intrinsic crystalline peak of PDA disappeared by formation of nanoparticle with HA at XRD measurement. These results indicated that PDA-incorporated HA nanoparticles were formed by ion-complex formation. At drug release study, the higher PDA contents induced faster release rate from nanoparticles. PDA-incorporated nanoparticles showed reduced intrinsic toxicity against HaCaT human keratinocyte cells at MTT assay and apoptosis assay. We suggest that PDA-incorporated HA nanoparticles are promising candidates for novel permanent hair dye.
authors.affiliation: Department of Beauty Stylist, Yeonsung University, Gyeonggido, Korea.
authors.forename: Hye-Young
authors.initials: HY
authors.lastname: Lee
authors.forename: Young-Il
authors.initials: YI
authors.lastname: Jeong
authors.forename: Da-Hye
authors.initials: DH
authors.lastname: Kim
authors.forename: Ki-Choon
authors.initials: KC
authors.lastname: Choi
mesh_terms: D002460:Cell Line; D003692:Delayed-Action Preparations / Q000009:adverse effects / Q000737:chemistry / Q000493:pharmacokinetics / Q000494:pharmacology; D004353:Drug Evaluation, Preclinical; D006202:Hair Dyes / Q000009:adverse effects / Q000737:chemistry* / Q000493:pharmacokinetics* / Q000494:pharmacology; D006801:Humans; D006820:Hyaluronic Acid / Q000009:adverse effects / Q000737:chemistry* / Q000493:pharmacokinetics* / Q000494:pharmacology; D053758:Nanoparticles / Q000009:adverse effects / Q000737:chemistry*; D010316:Particle Size; D010655:Phenylenediamines / Q000009:adverse effects / Q000737:chemistry / Q000493:pharmacokinetics / Q000494:pharmacology
chemical_list: D003692:Delayed-Action Preparations; D006202:Hair Dyes; D010655:Phenylenediamines; D006820:Hyaluronic Acid