title: [Vascular remodeling indicators and their impact on prognosis in patients with chronic heart failure].
abstract: OBJECTIVE
  To estimate vascular remodeling indicators and their impact on prognosis in patients with chronic heart failure (CHF).
  
  
  METHODS
  The study enrolled 128 patients with prior myocardial infarction and CHF and 40 individuals as a comparison group. Endothelium-dependent and -independent vasodilation (EDV and EIDV) was studied in the reactive hyperemia (RH) test and nitroglycerin (NTG) test. Carotid artery (CA) intima-media thickness (IMT) and great arterial rigidity were studied.
  
  
  RESULTS
  As compared to the control subjects, the patients with CHF were found to have EDV and EIVD reductions that were more pronounced in those with Functional Class IV CHF, more CA IMT, and abnormal arterial rigidity. There were relationships of EDV and EIDV to CA IMT (r = -0.30; p = 0.02) and aortic pulse wave velocity (APWV) (r = -0.30; p = 0.05). Multivariate analysis showed that the risk for cardiovascular events (CVE) in the CHF patients with an APWV of > 12 m/sec during a year was 2.02 times higher than in those with an APWV of < or = 12 m/sec (relative risk 2.02, 95 confidence interval, 1.01-4.03).
  
  
  CONCLUSIONS
  APWV is an independent risk factor of CVE in patients with CHF.
authors.forename: N A
authors.initials: NA
authors.lastname: Kosheleva
authors.forename: A P
authors.initials: AP
authors.lastname: Rebrov
mesh_terms: D001011:Aorta / Q000378:metabolism; D001783:Blood Flow Velocity; D059168:Carotid Intima-Media Thickness; D016022:Case-Control Studies; D002908:Chronic Disease; D004730:Endothelium, Vascular / Q000187:drug effects / Q000378:metabolism*; D005260:Female; D006333:Heart Failure / Q000503:physiopathology*; D006801:Humans; D006940:Hyperemia / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D009203:Myocardial Infarction / Q000503:physiopathology*; D005996:Nitroglycerin / Q000008:administration & dosage; D011379:Prognosis; D012307:Risk Factors; D014664:Vasodilation / Q000187:drug effects
chemical_list: D005996:Nitroglycerin