title: PET and SPECT tracers for glutamate receptors.
abstract: Radioligands for PET imaging of glutamate receptors will have the potential for studying neurological and neuropsychiatric disorders and their diagnosis and therapeutic intervention. Glutamate is the major excitatory neurotransmitter in the brain and is implicated in the pathophysiology of many neurodegenerative and neuropsychiatric disorders. Glutamate and its receptors are potential targets in the treatment of these disorders. Glutamate signaling is mediated through ionotropic and metabotropic receptors. The abundant concentration of these receptors can facilitate their in vivo quantification using positron emission tomography (PET). Glutamate receptors are a potentially important set of targets for monitoring disease progression, for evaluating the effect of therapy and for new treatment development based on the quantification of receptor occupancy. Here, we review the PET and single-photon emission computed tomography (SPECT) radioligands that have been developed for imaging glutamate receptors in living brain.
authors.affiliation: Division of Molecular Imaging and Neuropathology, Department of Psychiatry, Columbia University, New York, NY 10032, USA.
authors.forename: Vattoly J
authors.initials: VJ
authors.lastname: Majo
authors.forename: Jaya
authors.initials: J
authors.lastname: Prabhakaran
authors.forename: J John
authors.initials: JJ
authors.lastname: Mann
authors.forename: J S Dileep
authors.initials: JS
authors.lastname: Kumar
mesh_terms: D000818:Animals; D001921:Brain / Q000000981:diagnostic imaging* / Q000378:metabolism; D006801:Humans; D049268:Positron-Emission Tomography; D011849:Radioactive Tracers; D017470:Receptors, Glutamate / Q000378:metabolism*; D015899:Tomography, Emission-Computed, Single-Photon
chemical_list: D011849:Radioactive Tracers; D017470:Receptors, Glutamate