title: Protective influence of vitamin E on the antioxidant defence system in the whole blood and liver of normal and alloxan-induced diabetic rats.
abstract: The effect of oral administration of vitamin E for twenty-eight consecutive days on blood glucose, reduced glutathione levels, antioxidant enzymes (superoxide dismutase and catalase activities), and levels of malondialdehyde (as an index of free radical-mediated lipid peroxidation) was observed in the whole blood and liver of normal and alloxan-induced diabetic rats. It was found that oral administration of vitamin E significantly (p<0.05) lowered the blood glucose level and increased the body weight of the diabetic rats. The activities of superoxide dismutase and levels of reduced glutathione increased significantly (p<0.05) while the level of lipid peroxidation decreased.
authors.affiliation: Department of Biochemistry, University of Ado-Ekiti, P.M.B. 5363, Ado-Ekiti, Nigeria.
authors.forename: J O
authors.initials: JO
authors.lastname: Olanlokun
keywords: Antioxidant enzymes; Diabetes; Lipid Peroxidation; Reduced glutathione; Vitamin E