title: Phosphoinositides and cardiovascular diseases.
abstract: Phosphoinositides (PIs), a family of phosphorylated derivatives of the membrane lipid phosphatidylinositol, are established regulators of multiple cellular functions. An increasing amount of evidence has highlighted potential links between PI-mediated signaling pathways and the etiology of many human diseases, including cardiovascular pathologies. This chapter will provide a detailed overview of the peculiar functions of the major cardiovascular PIs in the pathogenesis of atherosclerosis, heart failure, and arrhythmias.
authors.affiliation: Department of Genetics, Biology and Biochemistry, University of Torino, Molecular Biotechnology Center, Italy.
authors.forename: Alessandra
authors.initials: A
authors.lastname: Ghigo
authors.forename: Alessia
authors.initials: A
authors.lastname: Perino
authors.forename: Emilio
authors.initials: E
authors.lastname: Hirsch
mesh_terms: D000818:Animals; D001145:Arrhythmias, Cardiac / Q000209:etiology; D050197:Atherosclerosis / Q000209:etiology; D002318:Cardiovascular Diseases / Q000209:etiology*; D006333:Heart Failure / Q000209:etiology; D006801:Humans; D010716:Phosphatidylinositols / Q000502:physiology*
chemical_list: D010716:Phosphatidylinositols