title: A new spirocyclic compound from the liquid culture of entomogenous fungus Isaria cateniannulata.
abstract: A new spirocyclic compound named (2S, 5S, 7S)-3α-hydroxyl-exogonic acid (1) was isolated from the liquid culture of entomogenous fungus Isaria cateniannulata. The structure and relative stereochemistry of 1 were elucidated by extensive spectroscopic analysis and by comparison of its NMR data with those of known compound. Compound 1 showed weak inhibitory activity against HeLa with IC(50) value of 80.5 μg ml(- 1).
authors.affiliation: Key Laboratory of Pharmaceutical Chemistry and Molecular Diagnosis of Ministry of Education, Hebei University, Baoding 071002, China. yxl19830915@163.com
authors.forename: Xiao-Long
authors.initials: XL
authors.lastname: Yang
authors.forename: Zhuang-Zhuang
authors.initials: ZZ
authors.lastname: Li
authors.forename: Su
authors.initials: S
authors.lastname: Zhang
authors.forename: He
authors.initials: H
authors.lastname: Yu
authors.forename: Hua-Jie
authors.initials: HJ
authors.lastname: Zhu
authors.forename: Du-Qiang
authors.initials: DQ
authors.lastname: Luo
mesh_terms: D000465:Algorithms; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D005663:Furans / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D006367:HeLa Cells; D006801:Humans; D006999:Hypocreales / Q000737:chemistry*; D020128:Inhibitory Concentration 50; D015394:Molecular Structure; D013141:Spiro Compounds / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D013237:Stereoisomerism
chemical_list: C578807:(2S,5S,7S)-3alpha-hydroxylexogonic acid; D000970:Antineoplastic Agents; D005663:Furans; D013141:Spiro Compounds