title: Analysis of Bcl I and Xba I polymorphism in factor VIII gene to detect carriers of haemophilia a in Andhra Pradesh.
abstract: The efficacy of two intragenic polymorphic markers of factor VIII gene has been examined in Andhra Pradesh population with a view to confirm/revise the strategy for carrier detection that would be precise and economical. The haemophilia A carrier was detected using Bcl I and Xba I polymorphic sites in intron 18 and 22 respectively. The cumulative efficiency of these two sites for detection of carriers is 100% since all 15 families tested were informative for one of these polymorphisms, thus confirming their usefulness for factor VIII gene mutations found in Andhra Pradesh.
authors.affiliation: Institute of Genetics, Osmania University, Begumpet, 500 016 Hyderabad, (AP)  ; Hospital for Genetic Diseases, Osmania University, Begumpet, 500 016 Hyderabad, (AP).
authors.forename: P Aruna
authors.initials: PA
authors.lastname: Prabhavathi
authors.forename: Tajamul
authors.initials: T
authors.lastname: Hussain
authors.forename: G N
authors.initials: GN
authors.lastname: Mallikarjuna Rao
authors.forename: Mp Js
authors.initials: MJ
authors.lastname: Anandaraj
keywords: Bcl I and Xba I polymorphisms and carrier detection; Haemophilia A; PCR