title: Rigid Mn(II) chelate as efficient MRI contrast agent for vascular imaging.
abstract: The aza-semi-crown pentadentate ligand rigidified by pyridine and piperidine rings was designed and synthesized. It can react with Mn(II) in water to form complex with improved longitudinal relaxivity, leading to efficient signal intensity enhancement of vascular vessels under a clinical magnetic resonance imaging scanner.
authors.affiliation: National Engineering Research Center for Biomaterials, Sichuan University, Chengdu 610064, PR China.
authors.forename: Hongying
authors.initials: H
authors.lastname: Su
authors.forename: Changqiang
authors.initials: C
authors.lastname: Wu
authors.forename: Jiang
authors.initials: J
authors.lastname: Zhu
authors.forename: Tianxin
authors.initials: T
authors.lastname: Miao
authors.forename: Dan
authors.initials: D
authors.lastname: Wang
authors.forename: Chunchao
authors.initials: C
authors.lastname: Xia
authors.forename: Xuna
authors.initials: X
authors.lastname: Zhao
authors.forename: Qiyong
authors.initials: Q
authors.lastname: Gong
authors.forename: Bin
authors.initials: B
authors.lastname: Song
authors.forename: Hua
authors.initials: H
authors.lastname: Ai
mesh_terms: D002614:Chelating Agents / Q000737:chemistry*; D003287:Contrast Media / Q000737:chemistry*; D056831:Coordination Complexes / Q000737:chemistry*; D047248:Crown Compounds / Q000737:chemistry; D018360:Crystallography, X-Ray; D006801:Humans; D008279:Magnetic Resonance Imaging; D008345:Manganese / Q000737:chemistry*; D008968:Molecular Conformation; D010880:Piperidines / Q000737:chemistry; D011725:Pyridines / Q000737:chemistry; D014680:Veins / Q000473:pathology
chemical_list: D002614:Chelating Agents; D003287:Contrast Media; D056831:Coordination Complexes; D047248:Crown Compounds; D010880:Piperidines; D011725:Pyridines; D008345:Manganese; C032727:piperidine; C023666:pyridine