title: Predicting carotid restenosis by comparison of plaque MCP-1 mRNA expression and serum levels.
abstract: As cardiovascular pathology grows in numbers, research into the discovery of new chemokine biomarkers should not be neglected, as they seem to be paramount in atherosclerosis prevention and its early detection. Chemokines attract and activate leukocytes and are well recognized in the environment of inflammatory response. MCP-1 is a valuable chemokine whose potential to become a new crucial atherosclerosis marker is surely worth investigating. Since quantities of MCP-1 found in lesions are as low as immeasurable, we propose the use of an immunohistochemical method for the quantification of MCP-1 levels in atherosclerotic lesions. Additionally, serum levels of MCP-1 can be measured by commercially available immunoassays. Proposed MCP-1 concentration increase may explain the acceleration in lesion's atherosclerosis progression as chemokine activation occurs once they bind to specific ligands. If proven, this hypothesis would indicate the need for further studies in order to objectively link the increased MCP-1 expression with carotid restenosis.
authors.affiliation: Cerebrovascular Clinic, Department of Neurology, Clinical Hospital Centre Rijeka, Croatia.
authors.forename: Ines Strenja
authors.initials: IS
authors.lastname: Linic
authors.forename: Ivan
authors.initials: I
authors.lastname: Sosa
authors.forename: Miljenko
authors.initials: M
authors.lastname: Kovacevic
authors.forename: Aldo
authors.initials: A
authors.lastname: Ivancic
authors.forename: Zlatko
authors.initials: Z
authors.lastname: Trobonjaca
authors.forename: Darko
authors.initials: D
authors.lastname: Ledic
authors.forename: Aron
authors.initials: A
authors.lastname: Grubesic
authors.forename: Stefica
authors.initials: S
authors.lastname: Dvornik
authors.forename: Sanja
authors.initials: S
authors.lastname: Stifter
mesh_terms: D016893:Carotid Stenosis / Q000175:diagnosis* / Q000473:pathology*; D018932:Chemokine CCL2 / Q000097:blood / Q000378:metabolism*; D006801:Humans; D007150:Immunohistochemistry / Q000379:methods*; D012333:RNA, Messenger / Q000378:metabolism*; D012008:Recurrence
chemical_list: C111835:CCL2 protein, human; D018932:Chemokine CCL2; D012333:RNA, Messenger