title: Spontaneous formation of heterogeneous patches on polymer-lipid core-shell particle surfaces during self-assembly.
abstract: Spontaneous formation of heterogeneous patches on the surface of lipid-based nanoparticles (NPs) and microparticles (MPs) due to the segregation of two different functional groups. Patch formation is observed when tracing the functional groups with quantum dots, gold nanoparticles, and fluorescent dyes. This discovery could have important implications for the future design of self-assembled NPs and MPs for different biomedical applications.
authors.affiliation: Department of Anesthesiology, Brigham and Women's Hospital-Harvard Medical School, Boston, MA 02115, USA.
authors.forename: Carolina
authors.initials: C
authors.lastname: Salvador-Morales
authors.forename: Pedro M
authors.initials: PM
authors.lastname: Valencia
authors.forename: Weiwei
authors.initials: W
authors.lastname: Gao
authors.forename: Rohit
authors.initials: R
authors.lastname: Karnik
authors.forename: Omid C
authors.initials: OC
authors.lastname: Farokhzad
mesh_terms: D008055:Lipids / Q000737:chemistry*; D053758:Nanoparticles / Q000737:chemistry*; D036103:Nanotechnology / Q000379:methods*; D010316:Particle Size; D011108:Polymers / Q000737:chemistry*; D013499:Surface Properties
chemical_list: D008055:Lipids; D011108:Polymers