title: Interaction of 5-amino-1,3,4-thiadiazole-2-thiol and its violuric acid adduct with Pt(II) - crystals structures, spectroscopic properties and cytotoxic activity.
abstract: The coordination properties of Pt(II) with 5-amino-1,3,4-thiadiazole-2-thiol [CAS 2349-67-9] (L  1 ) and its novel violurate adduct (L  2 ), both in solution and in solid state, are studied by means of conventional IR-spectroscopy, single crystal X-ray diffraction and thermal methods. The complex compounds of L  1  and L  2 , with general formulas [Pt(C2H2N3S2)2] and [Pt(C6H4N6S2O3)(Cl)]Cl respectively, are obtained. Quantum chemical calculations of the ligands are performed with a view to obtain electronic structure and optical properties of the ligands L  1  and L  2 , respectively. The cell viability of the ligands and metal complexes on a panel of human tumor cell lines is evaluated.
authors.affiliation: Department of Chemistry, Medical University, Sofia, Bulgaria.
authors.forename: M
authors.initials: M
authors.lastname: Kavlakova
authors.forename: A
authors.initials: A
authors.lastname: Bakalova
authors.forename: G
authors.initials: G
authors.lastname: Momekov
authors.forename: D
authors.initials: D
authors.lastname: Ivanov
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D001463:Barbiturates / Q000737:chemistry*; D045744:Cell Line, Tumor; D002470:Cell Survival; D004396:Coloring Agents; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D006860:Hydrogen Bonding; D007202:Indicators and Reagents; D008958:Models, Molecular; D008968:Molecular Conformation; D010984:Platinum / Q000737:chemistry*; D013055:Spectrophotometry, Infrared; D013778:Tetrazolium Salts; D013830:Thiadiazoles / Q000737:chemistry*; D013844:Thiazoles; D014961:X-Ray Diffraction
chemical_list: D000970:Antineoplastic Agents; D001463:Barbiturates; D004396:Coloring Agents; D007202:Indicators and Reagents; D013778:Tetrazolium Salts; D013830:Thiadiazoles; D013844:Thiazoles; C094277:violuric acid; C058949:1,3,4-thiadiazole; D010984:Platinum; C022616:thiazolyl blue