title: [Effect of Helicobacter pylori infection on platelet activation and coagulation function in patients with acute cerebral infarction].
abstract: OBJECTIVE
  To investigate the effect of Helicobacter pylori (Hp) on platelet activation and coagulation function in patients with acute cerebral infarction.
  
  
  METHODS
  Sixty-six patients with acute cerebral infarction and 50 health individuals were enrolled in the study. Hp antibody,expression of CD62p on platelets and clotting indexes were measured and compared between two groups.
  
  
  RESULTS
  The positive rate of Hp-IgG and Hp-CagA in cerebral infarction patients were higher than that in controls (P<0.05). The positive rate of CD62p in patients with positive Hp-IgG and Hp-CagA was significantly higher than that in negative patients and also controls (P<0.05). The APTT and TT were lower and FIB was higher in patients with positive Hp antibody than those in patients with negative Hp antibody (P<0.05),but there was no difference in PT,PTR and INR (P>0.05).
  
  
  CONCLUSIONS
  Hp infection can activate platelets and affect coagulation function,which may be involved in the development of cerebral infarction.
authors.affiliation: Department of Neurology, Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China. whq60@sohu.com
authors.forename: Hai-qin
authors.initials: HQ
authors.lastname: Wu
authors.forename: Yan
authors.initials: Y
authors.lastname: Tang
authors.forename: Xin
authors.initials: X
authors.lastname: Zhang
authors.forename: Xuan-hui
authors.initials: XH
authors.lastname: Wei
authors.forename: Hu-qing
authors.initials: HQ
authors.lastname: Wang
authors.forename: Wen-ting
authors.initials: WT
authors.lastname: Zhang
authors.forename: Gui-lian
authors.initials: GL
authors.lastname: Zhang
mesh_terms: D000328:Adult; D000368:Aged; D000907:Antibodies, Bacterial / Q000097:blood; D000942:Antigens, Bacterial / Q000378:metabolism; D001426:Bacterial Proteins / Q000378:metabolism; D001777:Blood Coagulation; D016022:Case-Control Studies; D002544:Cerebral Infarction / Q000097:blood* / Q000382:microbiology; D005260:Female; D016481:Helicobacter Infections / Q000097:blood* / Q000150:complications; D016480:Helicobacter pylori / Q000378:metabolism / Q000472:pathogenicity; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood; D008297:Male; D008875:Middle Aged; D019007:P-Selectin / Q000097:blood; D015539:Platelet Activation
chemical_list: D000907:Antibodies, Bacterial; D000942:Antigens, Bacterial; D001426:Bacterial Proteins; D007074:Immunoglobulin G; D019007:P-Selectin; C080866:cagA protein, Helicobacter pylori