title: An overview of the analytical methods for the determination of organic ultraviolet filters in biological fluids and tissues.
abstract: Organic UV filters are chemical compounds added to cosmetic sunscreen products in order to protect users from UV solar radiation. The need of broad-spectrum protection to avoid the deleterious effects of solar radiation has triggered a trend in the cosmetic market of including these compounds not only in those exclusively designed for sun protection but also in all types of cosmetic products. Different studies have shown that organic UV filters can be absorbed through the skin after topical application, further metabolized in the body and eventually excreted or bioaccumulated. These percutaneous absorption processes may result in various adverse health effects, such as genotoxicity caused by the generation of free radicals, which can even lead to mutagenic or carcinogenic effects, and estrogenicity, which is associated with the endocrine disruption activity caused by some of these compounds. Due to the absence of official monitoring protocols, there is a demand for analytical methods that enable the determination of UV filters in biological fluids and tissues in order to retrieve more information regarding their behavior in the human body and thus encourage the development of safer cosmetic formulations. In view of this demand, there has recently been a noticeable increase in the development of sensitive and selective analytical methods for the determination of UV filters and their metabolites in biological fluids (i.e., urine, plasma, breast milk and semen) and tissues. The complexity of the biological matrix and the low concentration levels of these compounds inevitably impose sample treatment processes that afford both sample clean-up to remove potentially interfering matrix components as well as the enrichment of analytes in order to achieve their determination at very low concentration levels. The aim of this review is to provide a comprehensive overview of the recent developments in the determination of UV filters in biological fluids and tissues, with special emphasis on the elucidation of new metabolites, sample preparation and analytical techniques as well as occurrence levels.
authors.affiliation: Departamento de Química Analítica, Facultad de Química, Universitat de València, Spain. alberto.chisvert@uv.es
authors.forename: Alberto
authors.initials: A
authors.lastname: Chisvert
authors.forename: Zacarías
authors.initials: Z
authors.lastname: León-González
authors.forename: Isuha
authors.initials: I
authors.lastname: Tarazona
authors.forename: Amparo
authors.initials: A
authors.lastname: Salvador
authors.forename: Dimosthenis
authors.initials: D
authors.lastname: Giokas
mesh_terms: D000818:Animals; D001826:Body Fluids / Q000737:chemistry* / Q000378:metabolism; D006801:Humans; D009930:Organic Chemicals / Q000032:analysis* / Q000378:metabolism / Q000493:pharmacokinetics; D014018:Tissue Distribution
chemical_list: D009930:Organic Chemicals