title: Polymorphisms in the p63 and p73 genes are associated with ovarian cancer risk and clinicopathological variables.
abstract: OBJECTIVE
  p73 and p63 are two structural and functional homologs of p53, and their biological functions in cancer progression have attracted attention due to the presence of variants generated by genetic polymorphisms. Recently, three single nucleotide polymorphisms (SNPs) in the p63 and p73 genes have been associated with female reproduction. In the present study, we aimed to evaluate the relationship between these SNPs and ovarian cancer susceptibility and clinical pathology.
  
  
  METHODS
  We genotyped the p63 (rs873330 [Genbank, refSNP ID] T > C [T: original base, C: mutant base]) and p73 (rs4648551 G > A and rs6695978 G > A) SNPs in ovarian cancers and healthy controls and analyzed the distributions of genotype frequencies to evaluate the association of the genotypes with the risk of ovarian cancer and the clinicopathological characteristics. Logistic regression models were applied in statistical analyses.
  
  
  RESULTS
  Our research revealed that p73 rs6695978 G > A was significantly associated with ovarian cancer patients. Women with the A allele were at increased risk of ovarian cancer compared to carriers of the G allele (OR = 1.55; 95% CI:1.07-2.19; P = 0.003). Meanwhile, the at-risk A allele was positively related with the occurrence of mucinous ovarian cancer (OR = 3.48; 95% CI:1.15-6.83; P = 0.001), low degree of differentiation (OR = 1.87; 95% CI:1.03-3.47; P = 0.003), lymph node metastasis (OR = 1.69; 95% CI: 1.14-2.75; P = 0.010) and estrogen receptor positive (OR = 2.72; 95% CI: 1.38-4.81; P = 0.002). However, we were unable to find any associations of the polymorphisms in another two SNPs (rs4648551 G > A, rs873330 T > C) with ovarian cancer risk and clinicopathological parameters.
  
  
  CONCLUSIONS
  The p73 rs6695978 G > A polymorphism will serve as a modifier of ovarian cancer susceptibility and prognosis. Further investigations with large sample sizes and of the mechanistic relevance of p73 polymorphism will be warranted.
authors.affiliation: Department of Obstetrics and Gynecology, Qilu Hospital, Shandong University, 107#, Wenhua Xi Road, Jinan, PR China.
authors.forename: Xiao
authors.initials: X
authors.lastname: Guan
authors.forename: Ning
authors.initials: N
authors.lastname: Zhang
authors.forename: Yongshuo
authors.initials: Y
authors.lastname: Yin
authors.forename: Beihua
authors.initials: B
authors.lastname: Kong
authors.forename: Qifeng
authors.initials: Q
authors.lastname: Yang
authors.forename: Zhiyan
authors.initials: Z
authors.lastname: Han
authors.forename: Xingsheng
authors.initials: X
authors.lastname: Yang
mesh_terms: D000328:Adult; D000483:Alleles; D004268:DNA-Binding Proteins / Q000235:genetics*; D004198:Disease Susceptibility; D005260:Female; D056726:Genetic Association Studies; D006239:Haplotypes; D006801:Humans; D008565:Membrane Proteins / Q000235:genetics*; D008875:Middle Aged; D009687:Nuclear Proteins / Q000235:genetics*; D010051:Ovarian Neoplasms / Q000235:genetics / Q000473:pathology; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors; D000072160:Tumor Protein p73; D025521:Tumor Suppressor Proteins / Q000235:genetics*
chemical_list: C081876:CKAP4 protein, human; D004268:DNA-Binding Proteins; D008565:Membrane Proteins; D009687:Nuclear Proteins; C000606460:TP73 protein, human; D000072160:Tumor Protein p73; D025521:Tumor Suppressor Proteins