title: 2-Arylbenzofuran and tyrosinase inhibitory constituents of Morus notabilis.
abstract: Phytochemical investigation of the stem of Morus notabilis led to the isolation and characterization of 10 compounds of 2-arylbenzofurans (1-10), including two new compounds, (2'R)-2',3'-dihydro-2'-(1-hydroxy-1-methylethyl)-2,6'-bibenzofuran-6,4'-diol (1) and 5,6-dimethoxy-2-(3-hydroxy-5-methoxyphenyl)benzofuran (2). Moracins O (6) and P (10) showed inhibitory effects on mushroom tyrosinase with IC₅₀ values being lower than that of kojic acid.
authors.affiliation: Department of Pharmacognosy, School of Pharmacy, Fudan University, Shanghai 201203, China.
authors.forename: Xiao
authors.initials: X
authors.lastname: Hu
authors.forename: Meng
authors.initials: M
authors.lastname: Wang
authors.forename: Gui-Rui
authors.initials: GR
authors.lastname: Yan
authors.forename: Mei-Hua
authors.initials: MH
authors.lastname: Yu
authors.forename: He-Yao
authors.initials: HY
authors.lastname: Wang
authors.forename: Ai-Jun
authors.initials: AJ
authors.lastname: Hou
mesh_terms: D000363:Agaricales / Q000201:enzymology; D001572:Benzofurans / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D020128:Inhibitory Concentration 50; D015394:Molecular Structure; D014442:Monophenol Monooxygenase / Q000037:antagonists & inhibitors*; D031625:Morus / Q000737:chemistry*; D019906:Nuclear Magnetic Resonance, Biomolecular; D018547:Plant Stems / Q000737:chemistry
chemical_list: C578234:(2'R)-2',3'-dihydro-2'-(1-hydroxy-1-methylethyl)-2,6'-bibenzofuran-6,4'-diol; C578235:5,6-dimethoxy-2-(3-hydroxy-5-methoxyphenyl)benzofuran; D001572:Benzofurans; D004365:Drugs, Chinese Herbal; D014442:Monophenol Monooxygenase