title: [Roles of Wnt signaling in bone metabolism].
abstract: Wnts, palmitoylated and glycosylated molecules play a central role in the early development of organs and tissues. Wnts bind to receptor complexes of frizzled and low density lipoprotein-related protein 5/6, which in turn, activate theβ-catenin-dependent canonical pathway. Wnt5a, a typical non-canonical ligand, activates theβ-catenin-independent noncanonical pathways such as the Wnt/Ca pathway and the Wnt/planar cell polarity pathway. Recent studies have established that Wnt-mediated signals are crucial for bone formation and resorption. This review summarizes the current knowledge of the roles of Wnt signaling in bone formation and resorption.
authors.affiliation: Institute for Oral Science, Matsumoto Dental University, Japan.
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Kobayashi
mesh_terms: D000818:Animals; D001862:Bone Resorption; D001842:Bone and Bones / Q000378:metabolism*; D006801:Humans; D010012:Osteogenesis; D015398:Signal Transduction / Q000502:physiology*; D051153:Wnt Proteins / Q000378:metabolism; D051176:beta Catenin / Q000378:metabolism
chemical_list: D051153:Wnt Proteins; D051176:beta Catenin