title: [The impact of antihypertensive therapy on cerebral hemodynamics in patients with metabolic syndrome].
abstract: The aim of this work was the scintigraphic study of brain perfusion and the elucidation of the relationship between daily variations of arterial pressure (AP) and the results of single photon emission computed tomography (SPCT) of the brain in patients with metabolic syndrome (MS). The secondary objective was to estimate effect of combined antihypertensive therapy on cerebral circulation. 24 patients with MS underwent SPCT with 99mTc HMPOA and 24 hr AP monitoring before and 6 mo after therapy with long-acting verapamil combined with slow-release indapamide or enalapril. It was shown that all the patients suffered disturbances of regional cerebral blood flow even in the absence of focal neurological symptoms. Perfusion was especially impaired in the temporal, occipital and superior frontal lobes. The degree of the night-time fall in AP was related to the level of perfusion in the right temporal region (r = -0.5; p = 0.04) which confirms the danger of extreme AD decrease in hypertonics during sleep. Combined antihypertensive therapy has positive influence on cerebral perfusion. Verapamil plus enalapril has more pronounced effect than verapamil plus indapamide on cerebral blood flow in many brain regions.
authors.forename: I Iu
authors.initials: IIu
authors.lastname: Efimova
authors.forename: T P
authors.initials: TP
authors.lastname: Kalashnikova
authors.forename: Iu B
authors.initials: IuB
authors.lastname: Lishmanov
mesh_terms: D000959:Antihypertensive Agents / Q000008:administration & dosage / Q000493:pharmacokinetics; D001682:Biological Availability; D018660:Blood Pressure Monitoring, Ambulatory / Q000379:methods; D001921:Brain / Q000503:physiopathology; D002560:Cerebrovascular Circulation / Q000187:drug effects*; D004359:Drug Therapy, Combination; D004656:Enalapril / Q000008:administration & dosage / Q000493:pharmacokinetics; D005260:Female; D006801:Humans; D006973:Hypertension / Q000150:complications / Q000175:diagnosis / Q000188:drug therapy / Q000503:physiopathology; D007190:Indapamide / Q000008:administration & dosage / Q000493:pharmacokinetics; D008297:Male; D024821:Metabolic Syndrome / Q000209:etiology*; D008875:Middle Aged; D015899:Tomography, Emission-Computed, Single-Photon / Q000379:methods*; D016896:Treatment Outcome; D014700:Verapamil / Q000008:administration & dosage / Q000493:pharmacokinetics
chemical_list: D000959:Antihypertensive Agents; D004656:Enalapril; D014700:Verapamil; D007190:Indapamide