title: An experimentally validated finite element method for augmented vertebral bodies.
abstract: BACKGROUND
  Finite element models of augmented vertebral bodies require a realistic modelling of the cement infiltrated region. Most methods published so far used idealized cement shapes or oversimplified material models for the augmented region. In this study, an improved, anatomy-specific, homogenized finite element method was developed and validated to predict the apparent as well as the local mechanical behavior of augmented vertebral bodies.
  
  
  METHODS
  Forty-nine human vertebral body sections were prepared by removing the cortical endplates and scanned with high-resolution peripheral quantitative CT before and after injection of a standard and a low-modulus bone cement. Forty-one specimens were tested in compression to measure stiffness, strength and contact pressure distributions between specimens and loading-plates. From the remaining eight, fourteen cylindrical specimens were extracted from the augmented region and tested in compression to obtain material properties. Anatomy-specific finite element models were generated from the CT data. The models featured element-specific, density-fabric-based material properties, damage accumulation, real cement distributions and experimentally determined material properties for the augmented region. Apparent stiffness and strength as well as contact pressure distributions at the loading plates were compared between simulations and experiments.
  
  
  RESULTS
  The finite element models were able to predict apparent stiffness (R(2)>0.86) and apparent strength (R(2)>0.92) very well. Also, the numerically obtained pressure distributions were in reasonable quantitative (R(2)>0.48) and qualitative agreement with the experiments.
  
  
  CONCLUSIONS
  The proposed finite element models have proven to be an accurate tool for studying the apparent as well as the local mechanical behavior of augmented vertebral bodies.
authors.affiliation: Institute of Lightweight Design and Structural Biomechanics, Vienna University of Technology, Vienna, Austria. kinzl@ilsb.tuwien.ac.at
authors.forename: Michael
authors.initials: M
authors.lastname: Kinzl
authors.forename: Jakob
authors.initials: J
authors.lastname: Schwiedrzik
authors.forename: Philippe K
authors.initials: PK
authors.lastname: Zysset
authors.forename: Dieter H
authors.initials: DH
authors.lastname: Pahr
mesh_terms: D001843:Bone Cements; D004548:Elasticity; D020342:Finite Element Analysis; D006801:Humans; D008422:Materials Testing; D008953:Models, Anatomic; D011859:Radiography; D013131:Spine / Q000000981:diagnostic imaging* / Q000502:physiology* / Q000601:surgery; D013314:Stress, Mechanical; D054854:Vertebroplasty; D016474:Weight-Bearing
chemical_list: D001843:Bone Cements