title: Design of highly potent HIV fusion inhibitors based on artificial peptide sequences.
abstract: Specific interactions were introduced between an artificial heptad repeat peptide template and HIV-1 gp41 for fusion inhibitor design, using a structure based rational design strategy. The designed peptides are nonhomologous with naturally occurring peptide and protein sequences, specifically interact with HIV-1 gp41, and show strong anti-HIV activity.
authors.affiliation: Department of Medicinal Chemistry, Beijing Institute of Pharmacology & Toxicology, 27 Taiping Rd, Haidian District, Beijing 100850, China.
authors.forename: Weiguo
authors.initials: W
authors.lastname: Shi
authors.forename: Lifeng
authors.initials: L
authors.lastname: Cai
authors.forename: Lu
authors.initials: L
authors.lastname: Lu
authors.forename: Chao
authors.initials: C
authors.lastname: Wang
authors.forename: Kun
authors.initials: K
authors.lastname: Wang
authors.forename: Liang
authors.initials: L
authors.lastname: Xu
authors.forename: Sha
authors.initials: S
authors.lastname: Zhang
authors.forename: Han
authors.initials: H
authors.lastname: Han
authors.forename: Xifeng
authors.initials: X
authors.lastname: Jiang
authors.forename: Baohua
authors.initials: B
authors.lastname: Zheng
authors.forename: Shibo
authors.initials: S
authors.lastname: Jiang
authors.forename: Keliang
authors.initials: K
authors.lastname: Liu
mesh_terms: D000595:Amino Acid Sequence; D019380:Anti-HIV Agents / Q000737:chemistry / Q000494:pharmacology*; D015195:Drug Design; D015700:HIV Envelope Protein gp41 / Q000737:chemistry; D015497:HIV-1 / Q000187:drug effects / Q000502:physiology*; D008969:Molecular Sequence Data; D057786:Peptidomimetics / Q000737:chemistry / Q000494:pharmacology*; D020449:Repetitive Sequences, Amino Acid; D053586:Virus Internalization / Q000187:drug effects*
chemical_list: D019380:Anti-HIV Agents; D015700:HIV Envelope Protein gp41; D057786:Peptidomimetics; C514787:gp41 protein, Human immunodeficiency virus 1