title: Amino acid scoring patterns for protein quality assessment.
abstract: The 1985 FAO/WHO/UNU protein report defined reference amino acid patterns for infants based on breast milk and for preschool children, schoolchildren and adults from age specific estimates of dietary indispensible amino acid requirements divided by the safe protein requirement for each age group. This report argued that the protein quality of a diet should be estimated from its digestibility adjusted by its amino acid score calculated from its limiting amino acid in comparison with the reference amino acid pattern. Subsequently a joint FAO/WHO expert consultation on protein quality evaluation (1991) endorsed this protein digestibility-corrected score approach. However it rejected the adult scoring pattern identified in the 1985 report arguing that the amino acid values for this pattern were too low. As an interim measure it suggested that the scoring pattern for preschool children should be used for all age groups apart from infants. The recent WHO/FAO/UNU (2007) report endorsed the 1985 report in recommending the amino acid content of breast milk as the best estimate of infant amino acid requirements. However it was only able to identify reliable requirement values for adults and adopted a factorial approach to derivation of age-related scoring patterns. This utilized the adult pattern for maintenance, and the pattern of human tissue protein for growth. Thus scoring patterns were derived for children aged 0·5, 1-2, 3-10, 11-14, 15-18 years and for adults. The total dietary amino acid requirements calculated for these age groups were divided by the mean protein requirement to give the scoring pattern which should be used to adjust digestible intakes to identify the available protein in specific diets. However because the adult values were determined in subjects at protein intakes much higher than the mean minimum protein requirement, i.e. at 1 g/kg/d rather than 0·66 g/kg/d, the pattern is likely to include higher values than the minimum requirement and should therefore be referenced against the safe allowance.
authors.affiliation: Division of Nutritional Sciences, Faculty of Health and Medical Sciences, University of Surrey, Guildford GU2 7XH, UK. D.Millward@surrey.ac.uk
authors.forename: D Joe
authors.initials: DJ
authors.lastname: Millward
mesh_terms: D000328:Adult; D000367:Age Factors; D000596:Amino Acids / Q000032:analysis / Q000378:metabolism*; D000601:Amino Acids, Essential / Q000032:analysis / Q000378:metabolism; D002648:Child; D002675:Child, Preschool; D004032:Diet; D004044:Dietary Proteins / Q000032:analysis / Q000378:metabolism*; D004063:Digestion; D002149:Energy Intake; D006128:Growth; D006801:Humans; D007223:Infant; D008895:Milk, Human / Q000378:metabolism; D018673:Nutrition Policy; D009751:Nutritional Requirements; D009753:Nutritive Value; D012016:Reference Values
chemical_list: D000596:Amino Acids; D000601:Amino Acids, Essential; D004044:Dietary Proteins