title: Pattern recognition receptors--molecular orchestrators of inflammation in inflammatory bowel disease.
abstract: Pattern recognition receptors (PRRs) are a family of germline encoded receptors responsible for the detection of "pathogen associated molecular patterns" (PAMPs) or host derived "damage associated molecular patterns" (DAMPs) which induce innate immune signalling to generate a pro-inflammatory profile within the host. Four main classes of PRRs are recognised, Toll-like receptors (TLRs), NOD-like receptors (NLRs), RIG-like receptors (RLRs) and C-type lectin receptors (CLRs). Abnormal activation of PRRs has been implicated in various autoimmune and inflammatory conditions including rheumatoid arthritis and asthma. Recent growing evidence has implicated these PRRs as contributory elements to the pathogenesis of inflammatory bowel disease (IBD) and colitis-associated cancer (CAC). Here, the current literature which implicates PRRs in IBD and CAC is comprehensively reviewed.
authors.affiliation: Pharmacodelivery Group, School of Pharmacy, University College Cork, Ireland.
authors.forename: David
authors.initials: D
authors.lastname: Walsh
authors.forename: Joanna
authors.initials: J
authors.lastname: McCarthy
authors.forename: Caitriona
authors.initials: C
authors.lastname: O'Driscoll
authors.forename: Silvia
authors.initials: S
authors.lastname: Melgar
mesh_terms: D000818:Animals; D006801:Humans; D015212:Inflammatory Bowel Diseases / Q000150:complications / Q000276:immunology*; D009369:Neoplasms / Q000209:etiology / Q000276:immunology; D051192:Receptors, Pattern Recognition / Q000276:immunology*
chemical_list: D051192:Receptors, Pattern Recognition