title: [Pharmaceutical follow up of antirretroviral treatment in outpatients].
abstract: Adherence to antiretroviral therapy is key contributor to decreasing morbidity and mortality from HIV/ AIDS infection. However, it is affected by treatment-related factors including the multiple adverse reactions and interactions arising from chronic polypharmacy. In order to determine drug-related problems, 66 outpatients from Hospital Carlos Van Buren on antiretroviral therapy were monitored. 100 % had medication-related problems and 46.1% of those problems were related to the safety of the therapy. Hypertriglyceridemia associated to the combined use of both nucleoside reverse transcriptase inhibitor and a non-nucleoside reverse transcriptase inhibitor was the most frequent adverse reaction. Results show that pharmacological monitoring of patients on antiretroviral treatment is necessary for the early identification of drug-related problems and for the proposal of alternatives that promote therapeutic safety and efficacy.
authors.affiliation: Departamento de Ciencias Farmacéuticas, Universidad de Valparaíso, Valparaíso, Chile. yanneth.moya@uv.cl
authors.forename: Yanneth
authors.initials: Y
authors.lastname: Moya
authors.forename: Fernando
authors.initials: F
authors.lastname: Bernal
authors.forename: Eliana
authors.initials: E
authors.lastname: Rojas
authors.forename: Elizabeth
authors.initials: E
authors.lastname: Barthel
mesh_terms: D000328:Adult; D000368:Aged; D019380:Anti-HIV Agents / Q000009:adverse effects*; D023241:Antiretroviral Therapy, Highly Active / Q000009:adverse effects*; D005260:Female; D005500:Follow-Up Studies; D015658:HIV Infections / Q000188:drug therapy*; D006801:Humans; D015228:Hypertriglyceridemia / Q000139:chemically induced / Q000209:etiology; D008297:Male; D055118:Medication Adherence; D008875:Middle Aged; D010045:Outpatients; D012959:Socioeconomic Factors; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D019380:Anti-HIV Agents