title: Is the polycystic ovary syndrome the causative of the increase in inflammatory markers and metabolic risk?
abstract: OBJECTIVE
  To investigate the relationship between the levels of C-reactive protein (CRP), interleukin-6 (IL-6) and IL-1β and the hormonal and metabolic alterations in women with polycystic ovary syndrome (PCO).
  
  
  METHODS
  Case-control study. CRP, IL-6 and IL-1β were evaluated in combination with obesity, insulin resistance (IR) and hyperandrogenism parameters in 20 patients with PCO. Twenty healthy women were used as the control.
  
  
  RESULTS
  The average CRP values was 5.1 in the cases vs. 0.8 mg/L in the control group (p < 0.0001). The IL-6 average values were 2.77 in the cases vs. 2.70 pg/ml in the control group (p = 0.254). IL-1β levels were found to be within the normal range in all individuals. A positive correlation was found between the CRP values and the IR (p < 0.0001) as well as with the presence of obesity (p < 0.02). No correlation was found between PCR and hyperandrogenemia (p = 0.4) nor between IL-6 values and IR (p = 0.3), or between the levels of this cytokine and the presence of hyperandrogenemia (p = 0.2). A significant correlation was found between IL-6 levels and obesity (p < 0.0001).
  
  
  CONCLUSIONS
  The present study demonstrates the presence of a chronic inflammation status in young women with PCO. These parameters are mainly related to obesity and, to a lesser extent, to IR.
authors.affiliation: Dr RA Margni, Humoral Immunity Studies Institute, School of Pharmacy and Biochemistry, University of Buenos Aires, Buenos Aires, Argentina.
authors.forename: Estela
authors.initials: E
authors.lastname: Rey-Roldan
authors.forename: Maria Belen
authors.initials: MB
authors.lastname: Perez Lana
authors.forename: Liliana
authors.initials: L
authors.lastname: Galluzzo
authors.forename: Georgina
authors.initials: G
authors.lastname: Blanco
authors.forename: Claudia
authors.initials: C
authors.lastname: Onetto
authors.forename: Vanesa
authors.initials: V
authors.lastname: Straminsky
authors.forename: Manuel Patricio
authors.initials: MP
authors.lastname: Nolting
mesh_terms: D000328:Adult; D001118:Argentina / Q000453:epidemiology; D015415:Biomarkers / Q000097:blood; D015992:Body Mass Index; D002097:C-Reactive Protein / Q000032:analysis*; D016022:Case-Control Studies; D015331:Cohort Studies; D005260:Female; D006801:Humans; D017588:Hyperandrogenism / Q000150:complications; D007333:Insulin Resistance; D053583:Interleukin-1beta / Q000097:blood; D015850:Interleukin-6 / Q000097:blood; D024821:Metabolic Syndrome / Q000150:complications / Q000453:epidemiology / Q000209:etiology*; D009765:Obesity / Q000150:complications / Q000503:physiopathology*; D011085:Polycystic Ovary Syndrome / Q000097:blood / Q000150:complications / Q000276:immunology / Q000503:physiopathology*; D012306:Risk; D012738:Sex Hormone-Binding Globulin / Q000032:analysis; D013739:Testosterone / Q000097:blood; D015854:Up-Regulation; D055815:Young Adult
chemical_list: D015415:Biomarkers; C508585:IL1B protein, human; C508600:IL6 protein, human; D053583:Interleukin-1beta; D015850:Interleukin-6; D012738:Sex Hormone-Binding Globulin; D013739:Testosterone; D002097:C-Reactive Protein