title: Relationship of systemic blood pressure with ocular perfusion pressure and intraocular pressure of glaucoma patients in telemedical home monitoring.
abstract: BACKGROUND
  We evaluated the relation of systemic blood pressure with intraday variations in ocular perfusion pressure and intraocular pressure in patients with primary open-angle glaucoma in a telemedical home monitoring scenario.
  
  
  METHODS
  In the project Teletonometry Mecklenburg-Vorpommern (TTMV) patients were equipped with a home monitoring system for 24-hour self-measurements of intraocular pressure and blood pressure for a period of six months. All measurements were transmitted via telephone modem to an electronic patient record. Ocular perfusion pressure (OPP) was automatically calculated from self-measurements of intraocular pressure (IOP), systolic (SBP) and diastolic blood pressure (DBP) using the equation: OPP=[2/3*(2/3*DBP+1/3*SBP)]-IOP. We present the temporal characteristics of 70 patients with primary open-angle glaucoma based on 3282 self-measurements.
  
  
  RESULTS
  The diurnal ocular perfusion pressure trend showed four characteristic phases (7am - 12am, 12am - 6pm, 6pm - 10pm, and 10pm - 7am). Between 7am and 12am ocular perfusion pressure and simultaneously systolic and diastolic blood pressure were significantly depressed compared to all other phases (p<0.05) whereas intraocular pressure showed no significant shifting. Instead intraocular pressure was significantly depressed between 6pm and 10pm (p<0.05) where ocular perfusion pressure reached the highest intraday values.
  
  
  CONCLUSIONS
  We found that ocular perfusion pressure in patients with primary open-angle glaucoma showed remarkable circadian fluctuations. A significant decrease in the morning was associated with significantly depressed systolic and diastolic blood pressure levels. In addition we observed normal intraocular pressure values in the morning but a significant decrease in the evening which did not affect ocular perfusion pressure. These conclusions strengthen the evidence that systemic blood pressure fundamentally influences ocular circulation and consequently glaucoma progression.
authors.affiliation: Department of Ophthalmology, University Medicine Greifswald, Greifswald, Germany. juergens@uni-greifswald.de
authors.forename: Clemens
authors.initials: C
authors.lastname: Jürgens
authors.forename: Rico
authors.initials: R
authors.lastname: Grossjohann
authors.forename: Frank H W
authors.initials: FH
authors.lastname: Tost
mesh_terms: D001794:Blood Pressure / Q000502:physiology*; D002940:Circadian Rhythm / Q000502:physiology; D003971:Diastole / Q000502:physiology; D005123:Eye / Q000098:blood supply* / Q000503:physiopathology*; D005260:Female; D005901:Glaucoma / Q000503:physiopathology*; D005902:Glaucoma, Open-Angle / Q000150:complications / Q000503:physiopathology; D006801:Humans; D006973:Hypertension / Q000150:complications / Q000503:physiopathology; D007429:Intraocular Pressure / Q000502:physiology*; D008875:Middle Aged; D008991:Monitoring, Physiologic / Q000379:methods*; D010477:Perfusion; D013599:Systole / Q000502:physiology; D017216:Telemedicine / Q000379:methods*