title: Association of obesity and diabetes with serum prostate-specific antigen levels in Japanese males.
abstract: Patients with diabetes have been reported to be at an increased risk for cancers of the pancreas, liver, and colon; however, recent studies have suggested that men with diabetes are at a decreased risk for prostate cancer. Previous studies have found that obese men have lower serum prostate-specific antigen (PSA) concentrations than do non-obese men. Further understanding of how obesity and diabetes affect the PSA concentration may improve our ability to detect clinically relevant prostate tumors. This study examined the relationships among serum PSA level, obesity, and diabetes in apparently healthy Japanese males. We analyzed the baseline data from 2,172 Japanese males (age, 56.8 +/- 6.1 years [mean +/- SD]) who participated in the Japan Multi-Institutional Collaborative Cohort Study. Diabetes was defined as the presence of both a hemoglobin A1c (JDS) of > or = 6.1% and a fasting plasma glucose level of > or = 126 mg/dL, or a positive medical history. After adjusting for age, the PSA levels were elevated among males with a higher normal BMI (ranging from 23.0 to 24.9) and lowered among men with a BMI of > or = 25.0. In the stratified analysis, these significant differences in BMI categories were absent among diabetics. The mean PSA levels were significantly lower in diabetics than in non-diabetics among subjects aged 60 and over. Our findings suggest that the pre-overweight men had increased PSA levels, and the diabetes was associated with a reduction of PSA levels in elderly.
authors.affiliation: Department of Preventive Medicine, Nagoya University Graduate School of Medicine, Nagoya, Japan. mnaito@med.nagoya-u.ac.jp
authors.forename: Mariko
authors.initials: M
authors.lastname: Naito
authors.forename: Yatami
authors.initials: Y
authors.lastname: Asai
authors.forename: Atsuyoshi
authors.initials: A
authors.lastname: Mori
authors.forename: Yuko
authors.initials: Y
authors.lastname: Fukada
authors.forename: Mayumi
authors.initials: M
authors.lastname: Kuwabara
authors.forename: Shiro
authors.initials: S
authors.lastname: Katase
authors.forename: Asahi
authors.initials: A
authors.lastname: Hishida
authors.forename: Emi
authors.initials: E
authors.lastname: Morita
authors.forename: Sayo
authors.initials: S
authors.lastname: Kawai
authors.forename: Rieko
authors.initials: R
authors.lastname: Okada
authors.forename: Kazuko
authors.initials: K
authors.lastname: Nishio
authors.forename: Akiko
authors.initials: A
authors.lastname: Tamakoshi
authors.forename: Kenji
authors.initials: K
authors.lastname: Wakai
authors.forename: Nobuyuki
authors.initials: N
authors.lastname: Hamajima
mesh_terms: D000368:Aged; D044466:Asian People; D015992:Body Mass Index; D003920:Diabetes Mellitus / Q000097:blood* / Q000453:epidemiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000097:blood* / Q000453:epidemiology; D017430:Prostate-Specific Antigen / Q000097:blood*
chemical_list: D017430:Prostate-Specific Antigen