title: [A syndrome of chronic ataxic polyneuropathy, ophtalmoplegia, IgM paraprotein, cold agglutinins and anti-disialosyl antibodies can cause diplopia in patients with chronic sensory polyneuropathy].
abstract: CANOMAD is a rare syndrome of chronic ataxic polyneuropathy, ophtalmoplegia, IgM paraprotein, cold agglutinins and anti-disialosyl antibodies. We present a case of a 65-year-old woman with clinical and electrophysiological features of chronic sensory polyneuropathy and diplopia. Serum samples from the patient contained IgM paraprotein and anti-GM2-antibodies. Treatment with intravenous immunoglobulins resulted in an improvement of the patient's diplopia and polyneuropathy. The case shows the importance of considering CANOMAD as a cause of diplopia in patients with chronic sensory polyneuropathy.
authors.affiliation: Neurologisk Afdeling, Odense Universitetshospital. eva_kolmos@hotmail.com
authors.forename: Eva Brøsted
authors.initials: EB
authors.lastname: Kolmos
authors.forename: Marie
authors.initials: M
authors.lastname: Moth Henriksen
authors.forename: Niels
authors.initials: N
authors.lastname: Abildgaard
authors.forename: Søren Hein
authors.initials: SH
authors.lastname: Sindrup
mesh_terms: D000368:Aged; D000744:Anemia, Hemolytic, Autoimmune / Q000175:diagnosis / Q000188:drug therapy / Q000276:immunology*; D001259:Ataxia / Q000175:diagnosis / Q000188:drug therapy / Q000276:immunology*; D002908:Chronic Disease / Q000188:drug therapy; D004172:Diplopia / Q000175:diagnosis / Q000188:drug therapy; D005099:Exotropia / Q000473:pathology; D005260:Female; D005732:Gangliosides / Q000097:blood / Q000276:immunology; D006801:Humans; D007075:Immunoglobulin M / Q000097:blood; D016756:Immunoglobulins, Intravenous / Q000627:therapeutic use; D008875:Middle Aged; D008998:Monoclonal Gammopathy of Undetermined Significance / Q000175:diagnosis / Q000188:drug therapy / Q000276:immunology*; D009886:Ophthalmoplegia / Q000175:diagnosis / Q000188:drug therapy / Q000276:immunology*; D011115:Polyneuropathies / Q000175:diagnosis / Q000188:drug therapy / Q000276:immunology*; D016896:Treatment Outcome
chemical_list: D005732:Gangliosides; D007075:Immunoglobulin M; D016756:Immunoglobulins, Intravenous