title: High-mobility group box family of proteins: ligand and sensor for innate immunity.
abstract: Recent discoveries in signal-transducing innate receptors have illustrated the close link between innate and adaptive immunity. These advances revisit a fundamental issue of immunology, the recognition of self and non-self molecules by the immune system. Indeed, mounting evidence has been provided that the sensing of self-derived molecules by the immune system is important for health and disease. The high-mobility group box (HMGB) proteins, particularly HMGB1, are self-derived immune activators that have multiple functions in the regulation of immunity and inflammation. In this review, we summarize current knowledge of the function of HMGB proteins, as a ligand that can evoke inflammatory responses, and as a sensor for nucleic-acid-mediated immune responses.
authors.affiliation: Department of Molecular Immunology, Institute of Industrial Science, The University of Tokyo, Komaba 4-6-1, Meguro-ku, Tokyo 153-8505, Japan.
authors.forename: Hideyuki
authors.initials: H
authors.lastname: Yanai
authors.forename: Tatsuma
authors.initials: T
authors.lastname: Ban
authors.forename: Tadatsugu
authors.initials: T
authors.lastname: Taniguchi
mesh_terms: D000818:Animals; D016207:Cytokines / Q000276:immunology; D024002:HMGB Proteins / Q000276:immunology*; D006801:Humans; D007113:Immunity, Innate; D008024:Ligands; D015398:Signal Transduction; D051193:Toll-Like Receptors / Q000276:immunology
chemical_list: D016207:Cytokines; D024002:HMGB Proteins; D008024:Ligands; D051193:Toll-Like Receptors