title: Accuracy and precision of CPET equipment: a comparison of breath-by-breath and mixing chamber systems.
abstract: Cardiopulmonary exercise testing (CPET) has become an important diagnostic tool for patients with cardiorespiratory disease and can monitor athletic performance measuring maximal oxygen uptake [Formula: see text]Vo2(; max). The aim of this study is to compare the accuracy and precision of a breath-by-breath and a mixing chamber CPET system, using two methods. First, this study developed a (theoretical) error analysis based on general error propagation theory. Second, calibration measurements using a metabolic simulator were performed. Error analysis shows that the error in oxygen uptake ([Formula: see text]Vo2) and carbon dioxide production (Vco2[Formula: see text]) is smaller for mixing chamber than for breath-by-breath systems. In general, the error of the flow sensor [Formula: see text]δV, the error in temperature of expired air δT(B) and the delay time error δt(delay) are significant sources of error. Measurements using a metabolic simulator show that breath-by-breath systems are less stabile for different values of minute ventilation than mixing chamber systems.
authors.affiliation: Eindhoven University of Technology, Department of Applied Physics, The Netherlands. c.beijst@gmail.com
authors.forename: Casper
authors.initials: C
authors.lastname: Beijst
authors.forename: Goof
authors.initials: G
authors.lastname: Schep
authors.forename: Eric van
authors.initials: Ev
authors.lastname: Breda
authors.forename: Pieter F F
authors.initials: PF
authors.lastname: Wijn
authors.forename: Carola van
authors.initials: Cv
authors.lastname: Pul
mesh_terms: D001944:Breath Tests / Q000295:instrumentation* / Q000379:methods*; D002138:Calibration; D002245:Carbon Dioxide / Q000032:analysis; D005080:Exercise Test / Q000295:instrumentation* / Q000379:methods / Q000592:standards*; D008954:Models, Biological; D010100:Oxygen / Q000032:analysis; D010101:Oxygen Consumption; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D013696:Temperature
chemical_list: D002245:Carbon Dioxide; D010100:Oxygen