title: Both BMI and waist circumference are associated with coronary vasoreactivity in overweight and obese men.
abstract: OBJECTIVE
  Guidelines differ about the value of assessment of adiposity measures for cardiovascular disease risk prediction. Reduced coronary vasoreactivity appears to be one of the earliest abnormalities in the development of coronary artery disease. We studied the associations of BMI, waist circumference, waist-to-hip ratio (WHR) and percentage of fat with coronary vasoreactivity.
  
  
  METHODS
  Myocardial blood flow was quantitated in 14 overweight or obese non-smoking men (age 32 ± 7 years, BMI 32 ± 3 kg/m², waist circumference 106 ± 9 cm, WHR 0.96 ± 0.04, %fat 27.2 ± 3.7) using positron emission tomography and oxygen-15-labelled water. The measurements were performed basally and during adenosine infusion (140 µg/kg/min) to measure coronary vasoreactivity.
  
  
  RESULTS
  Adenosine infusion induced significant increase in myocardial blood flow (from 0.8 ± 0.2 to 3.5 ± 0.9 ml/g/min). After adjustment for LDL-cholesterol, HbA(1c), systolic blood pressure and age, hyperaemic myocardial blood flow was inversely associated with BMI (r = -0.87, p = 0.001), waist circumference (r = -0.84, p = 0.003), WHR (r = -0.79, p = 0.007) and %fat (r = -0.65, p = 0.04).
  
  
  CONCLUSIONS
  Both BMI and waist circumference are associated with coronary vasoreactivity in overweight and obese men.
authors.affiliation: Turku PET Centre, University of Turku and Turku University Hospital, Turku, Finland. jan.sundell@utu.fi
authors.forename: Jan
authors.initials: J
authors.lastname: Sundell
authors.forename: Olli T
authors.initials: OT
authors.lastname: Raitakari
authors.forename: Jorma
authors.initials: J
authors.lastname: Viikari
authors.forename: Ilkka
authors.initials: I
authors.lastname: Kantola
authors.forename: Pirjo
authors.initials: P
authors.lastname: Nuutila
authors.forename: Juhani
authors.initials: J
authors.lastname: Knuuti
mesh_terms: D000241:Adenosine / Q000378:metabolism; D000328:Adult; D015992:Body Mass Index; D003326:Coronary Circulation / Q000502:physiology*; D003327:Coronary Disease / Q000209:etiology* / Q000378:metabolism; D003331:Coronary Vessels / Q000503:physiopathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000150:complications; D050177:Overweight / Q000150:complications*; D055105:Waist Circumference; D049629:Waist-Hip Ratio; D055815:Young Adult
chemical_list: D000241:Adenosine