title: Surgical resection and amniotic membrane transplantation for treatment of refractory giant papillae in vernal keratoconjunctivitis.
abstract: OBJECTIVE
  The aim of this study was to evaluate the outcome of surgical resection and amniotic membrane transplantation (AMT) for treatment of refractory symptomatic giant papillae in vernal keratoconjunctivitis (VKC).
  
  
  METHODS
  This is a retrospective study of 13 eyes of 9 patients with refractory giant papillae associated with corneal shield ulcer and/or punctate epithelial erosions who underwent surgical resection of the papillae combined with AMT to cover the tarsal conjunctival defect.
  
  
  RESULTS
  During 14.2 ± 4.2 months of postoperative follow-up, smooth tarsal conjunctival surface was achieved in all cases, with no recurrence of the giant papillae in any eye. Corneal shield ulcers and punctate epithelial erosions healed within 2 weeks after surgery and did not recur during the follow-up. Best-corrected visual acuity improved from 0.26 ± 0.21 logarithm of the minimum angle of resolution preoperatively to 0.02 ± 0.04 logarithm of the minimum angle of resolution postoperatively (P = 0.01). Three patients experienced recurrence of VKC symptoms, but without giant papillae, which could be well controlled by topical medications.
  
  
  CONCLUSIONS
  Surgical resection combined with AMT is an effective procedure for treatment of refractory giant papillae in patients with VKC.
authors.affiliation: Department of Ophthalmology, Shenzhen Eye Hospital, Jinan University, Shenzhen, China.
authors.forename: Ping
authors.initials: P
authors.lastname: Guo
authors.forename: Ahmad
authors.initials: A
authors.lastname: Kheirkhah
authors.forename: Wei-wei
authors.initials: WW
authors.lastname: Zhou
authors.forename: Lei
authors.initials: L
authors.lastname: Qin
authors.forename: Xiao-li
authors.initials: XL
authors.lastname: Shen
mesh_terms: D000328:Adult; D000650:Amnion / Q000637:transplantation*; D002648:Child; D003228:Conjunctiva / Q000473:pathology / Q000601:surgery*; D003233:Conjunctivitis, Allergic / Q000601:surgery*; D005260:Female; D006801:Humans; D006984:Hypertrophy; D008297:Male; D013508:Ophthalmologic Surgical Procedures; D012008:Recurrence; D012189:Retrospective Studies; D016896:Treatment Outcome; D055815:Young Adult