title: Meta-analysis and brain imaging data support the involvement of VRK2 (rs2312147) in schizophrenia susceptibility.
abstract: Recent genome-wide association studies have reported a set of schizophrenia susceptibility genes, but many of them await further replications in additional samples. Here we analyzed 5 genome-wide supported variants in a Han Chinese sample, and the variant rs2312147 at VRK2 showed significant association, which was confirmed in the meta-analysis combining multiple Asian and European samples (P=3.17×10(-4), N=7498). Rs2312147 is also associated with brain structure in healthy subjects, including the total brain volume and the white matter volume. Gene expression analyses indicated an up-regulation of VRK2 in schizophrenia patients. Our data provide further evidence for the contribution of VRK2 to schizophrenia.
authors.affiliation: State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, China.
authors.forename: Ming
authors.initials: M
authors.lastname: Li
authors.forename: Yi
authors.initials: Y
authors.lastname: Wang
authors.forename: Xue-bin
authors.initials: XB
authors.lastname: Zheng
authors.forename: Masashi
authors.initials: M
authors.lastname: Ikeda
authors.forename: Nakao
authors.initials: N
authors.lastname: Iwata
authors.forename: Xiong-jian
authors.initials: XJ
authors.lastname: Luo
authors.forename: Siow-Ann
authors.initials: SA
authors.lastname: Chong
authors.forename: Jimmy
authors.initials: J
authors.lastname: Lee
authors.forename: Marcella
authors.initials: M
authors.lastname: Rietschel
authors.forename: Fengyu
authors.initials: F
authors.lastname: Zhang
authors.forename: Bertram
authors.initials: B
authors.lastname: Müller-Myhsok
authors.forename: Sven
authors.initials: S
authors.lastname: Cichon
authors.forename: Daniel R
authors.initials: DR
authors.lastname: Weinberger
authors.forename: Manuel
authors.initials: M
authors.lastname: Mattheisen
authors.forename: Thomas G
authors.initials: TG
authors.lastname: Schulze
authors.forename: Nicholas G
authors.initials: NG
authors.lastname: Martin
authors.forename: Philip B
authors.initials: PB
authors.lastname: Mitchell
authors.forename: Peter R
authors.initials: PR
authors.lastname: Schofield
authors.forename: Jian-jun
authors.initials: JJ
authors.lastname: Liu
authors.forename: Bing
authors.initials: B
authors.lastname: Su
mesh_terms: D000328:Adult; D044466:Asian People; D001921:Brain / Q000473:pathology*; D016022:Case-Control Studies; D005260:Female; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D017346:Protein Serine-Threonine Kinases / Q000235:genetics*; D012559:Schizophrenia / Q000235:genetics* / Q000473:pathology*; D044465:White People; D055815:Young Adult
chemical_list: D017346:Protein Serine-Threonine Kinases; C109891:VRK2 protein, human