title: Template synthesis and spectral studies on mononuclear complexes of chromium(III) and manganese(II) with tetradentate N4 donor macrocycles.
abstract: The present article deals with the synthesis, spectral characterization and antimicrobial activity of a series of new complexes of chromium(III) and manganese(II)of general formula [Cr(Macn)Cl2]·Cl and [Mn(Macn)Cl2] respectively. These complexes were prepared via template reaction by mixing methanolic solution of diacetyldihydrazone, diacids (oxalic acid, succinic acid, glutaric acid and adipic acid) with CrCl3·6H2O and MnCl2·4H2O in 2:2:1 M ratios respectively. The newly synthesized complexes were characterized on the basis of chemical analysis and spectral studies like IR, UV, ESR and X-ray diffraction. An octahedral structure has been proposed for the chromium(III) and manganese(II)macrocyclic complexes. The synthesized complexes were further tested in vitro against fungi and bacteria in order to assess their antibacterial and antifungal activities. The studies demonstrate that the complexes possess antimicrobial properties.
authors.affiliation: Department of Chemistry, University of Rajasthan, Jaipur 302 004, India.
authors.forename: Raj
authors.initials: R
authors.lastname: Kumar
authors.forename: Iffat
authors.initials: I
authors.lastname: Masih
authors.forename: Nighat
authors.initials: N
authors.lastname: Fahmi
mesh_terms: D000890:Anti-Infective Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects; D001424:Bacterial Infections / Q000188:drug therapy; D002857:Chromium / Q000737:chemistry* / Q000494:pharmacology*; D056831:Coordination Complexes / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D004578:Electron Spin Resonance Spectroscopy; D005658:Fungi / Q000187:drug effects; D006801:Humans; D047028:Macrocyclic Compounds / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D008345:Manganese / Q000737:chemistry* / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D009181:Mycoses / Q000188:drug therapy; D013055:Spectrophotometry, Infrared; D013056:Spectrophotometry, Ultraviolet; D014961:X-Ray Diffraction
chemical_list: D000890:Anti-Infective Agents; D056831:Coordination Complexes; D047028:Macrocyclic Compounds; D002857:Chromium; D008345:Manganese