title: Lack of the QTc physiologic decrease during cardiac stress test in patients with type 2 diabetes treated with secretagogues.
abstract: Patients with type 2 diabetes are at increased susceptibility to a prolonged QT interval. Furthermore, insulin secretagogues, drugs used to treat diabetes, may prolong QT interval and provoke arrhythmias. We evaluated whether secretagogues can affect QTc interval during cardiac stress test in 20 patients with type 2 diabetes treated with secretagogues. ECG stress test was performed in all patients. QTc interval was calculated both before cardiac stress test (BCST) and at acme of cardiac stress test (ACST). Diabetic patients treated with secretagogues showed longer QTc-ACST values than those treated with metformin only. QTc-ACST values resulted shorter than QTc-BCST values in control group. Diabetic patients treated with secretagogues showed QTc-ACST values significantly longer than QTc-BCST values. In our study, diabetic patients treated with secretagogues did not show the QTc physiologic decrease that is a protective against arrhythmias. These results suggest to evaluate, in these patients, QT length, even during routine cardiac stress test.
authors.affiliation: Sapienza University, Rome, RM, Italy.
authors.forename: Mario
authors.initials: M
authors.lastname: Curione
authors.forename: Simonetta
authors.initials: S
authors.lastname: Di Bona
authors.forename: Silvia
authors.initials: S
authors.lastname: Amato
authors.forename: Irene
authors.initials: I
authors.lastname: Turinese
authors.forename: Giovanna
authors.initials: G
authors.lastname: Tarquini
authors.forename: Alessandra
authors.initials: A
authors.lastname: Gatti
authors.forename: Elisabetta
authors.initials: E
authors.lastname: Mandosi
authors.forename: Marco
authors.initials: M
authors.lastname: Rossetti
authors.forename: Marisa
authors.initials: M
authors.lastname: Varrenti
authors.forename: Stephanie
authors.initials: S
authors.lastname: Salvatore
authors.forename: Erika
authors.initials: E
authors.lastname: Baiocco
authors.forename: Susanna
authors.initials: S
authors.lastname: Morano
mesh_terms: D000368:Aged; D001145:Arrhythmias, Cardiac / Q000175:diagnosis / Q000209:etiology / Q000503:physiopathology; D002219:Carbamates / Q000627:therapeutic use*; D003924:Diabetes Mellitus, Type 2 / Q000150:complications / Q000188:drug therapy* / Q000503:physiopathology*; D004562:Electrocardiography; D005080:Exercise Test; D005260:Female; D005905:Glyburide / Q000627:therapeutic use*; D006339:Heart Rate / Q000187:drug effects* / Q000502:physiology; D006801:Humans; D007004:Hypoglycemic Agents / Q000627:therapeutic use*; D008297:Male; D008687:Metformin / Q000627:therapeutic use; D008875:Middle Aged; D010880:Piperidines / Q000627:therapeutic use*
chemical_list: D002219:Carbamates; D007004:Hypoglycemic Agents; D010880:Piperidines; C072379:repaglinide; D008687:Metformin; D005905:Glyburide