title: Influence of sutureless 23-gauge sclerotomy architecture on postoperative intraocular pressure decrease: results of a multivariate analysis.
abstract: OBJECTIVE
  To evaluate the factors affecting the postoperative intraocular pressure (IOP) decrease in 23-gauge (23-G) sutureless vitrectomy, including incision architecture evaluated by anterior segment spectral-domain optical coherence tomography (SD-OCT).
  
  
  METHODS
  A prospective cohort study of 43 patients who underwent primary transconjunctival 23-G pars plana vitrectomy. All sclerotomy wounds were imaged 1 day after surgery using the anterior segment module of SD-OCT (OCT Spectralis, Heidelberg Engineering, Heidelberg, Germany). 23-G sclerotomy architecture, preoperative and postoperative medical data were also prospectively collected.
  
  
  RESULTS
  Multivariate logistic regression analysis, with backward elimination, found that surgery duration (adjusted OR = 9.17, p = 0.020) and loss of wound apposition (adjusted OR = 15.12, p = 0.022) were risk factors for significant postoperative IOP decrease (≥3 mmHg) 1 day after surgery; while age, gender, myopia, and gas tamponade were not risk or protective factors for postoperative IOP decrease.
  
  
  CONCLUSIONS
  In 23-G pars plana vitrectomy, the early postoperative decrease in IOP is mainly influenced by surgery duration and the self-sealing nature of the sclerotomy. The IOP decrease was not influenced by the presence or the absence of gas tamponade.
authors.affiliation: Department of Ophthalmology II, Quinze-Vingts National Ophthalmology Hospital, 28, rue de Charenton, 75012, Paris, France. tjhr78@hotmail.com
authors.forename: Rachid
authors.initials: R
authors.lastname: Tahiri Joutei Hassani
authors.forename: Mohamed
authors.initials: M
authors.lastname: El Sanharawi
authors.forename: Raphael
authors.initials: R
authors.lastname: Adam
authors.forename: Claire
authors.initials: C
authors.lastname: Monin
authors.forename: Sylvère
authors.initials: S
authors.lastname: Dupont-Monod
authors.forename: Christophe
authors.initials: C
authors.lastname: Baudouin
mesh_terms: D000368:Aged; D058450:Endotamponade; D005260:Female; D005466:Fluorocarbons / Q000008:administration & dosage; D006801:Humans; D007429:Intraocular Pressure / Q000502:physiology*; D008297:Male; D008866:Microsurgery / Q000379:methods; D015999:Multivariate Analysis; D015814:Ocular Hypotension / Q000209:etiology* / Q000503:physiopathology; D011183:Postoperative Complications; D011446:Prospective Studies; D012307:Risk Factors; D012590:Sclera / Q000473:pathology*; D012599:Sclerostomy / Q000379:methods*; D013459:Sulfur Hexafluoride / Q000008:administration & dosage; D013536:Suture Techniques; D013997:Time Factors; D041623:Tomography, Optical Coherence; D014792:Visual Acuity / Q000502:physiology; D014821:Vitrectomy; D014945:Wound Healing
chemical_list: D005466:Fluorocarbons; C048381:perfluoroethane; C042852:perflutren; D013459:Sulfur Hexafluoride