title: [Combination of two signals of danger--a principal cause of activation of chronic inflammatory processes].
abstract: Chronic inflammatory processes have long current during which there is a change of remission by an aggravation of disease. Until recently was considered, that occurrence and activation of chronic inflammatory process is caused by one signal of danger. Most often it are served with microorganisms. The sum of our end literary data shows that activation is connected with accumulation in the center of an inflammation of macrophages and their hyperactivation as a result of action of two signals of danger--microorganisms and xenobiotics.
authors.forename: K A
authors.initials: KA
authors.lastname: Lebedev
mesh_terms: D000818:Animals; D006801:Humans; D007249:Inflammation / Q000276:immunology* / Q000473:pathology; D008262:Macrophage Activation; D008264:Macrophages / Q000276:immunology* / Q000473:pathology; D015398:Signal Transduction / Q000276:immunology*