title: Molecular and functional aspects of menstruation in the macaque.
abstract: Much of our understanding of the molecular control of menstruation arises from laboratory models that experimentally recapitulate some, but not all, aspects of uterine bleeding observed in women. These models include: in vitro culture of endometrial explants or isolated endometrial cells, transplantation of human endometrial tissue into immunodeficient mice and the induction of endometrial breakdown in appropriately pretreated mice. Each of these models has contributed to our understanding of molecular and cellular mechanisms of menstruation, but nonhuman primates, especially macaques, are the animal model of choice for evaluating therapies for menstrual disorders. In this chapter we review some basic aspects of menstruation, with special emphasis on the macaque model and its relevance to the clinical issues of irregular and heavy menstrual bleeding (HMB).
authors.affiliation: Division of Reproductive & Developmental Sciences, Oregon National Primate Research Center, Oregon Health and Science University, Beaverton, OR, USA. brennerr@ohsu.edu
authors.forename: Robert M
authors.initials: RM
authors.lastname: Brenner
authors.forename: Ov D
authors.initials: OD
authors.lastname: Slayden
mesh_terms: D000818:Animals; D004717:Endometrium / Q000502:physiology* / Q000503:physiopathology; D005260:Female; D006801:Humans; D008251:Macaca / Q000033:anatomy & histology / Q000502:physiology*; D008598:Menstruation / Q000502:physiology*; D008599:Menstruation Disturbances / Q000378:metabolism / Q000503:physiopathology / Q000662:veterinary; D010802:Phylogeny; D014599:Uterus / Q000033:anatomy & histology