title: DropletMicroarray: facile formation of arrays of microdroplets and hydrogel micropads for cell screening applications.
abstract: We describe a one-step method for creating thousands of isolated pico- to microliter-sized droplets with defined geometry and volume. Arrays of droplets are instantly formed as liquid moves along a superhydrophilic-superhydrophobic patterned surface. Bioactive molecules, nonadherent cells, or microorganisms can be trapped in the fully isolated microdroplets for high-throughput screening, or in hydrogel micropads for screening in 3D microenvironments.
authors.affiliation: Institute of Toxicology and Genetics, Karlsruhe Institute of Technology, Postfach 3640, 76021 Karlsruhe, Germany.
authors.forename: Erica
authors.initials: E
authors.lastname: Ueda
authors.forename: Florian L
authors.initials: FL
authors.lastname: Geyer
authors.forename: Victoria
authors.initials: V
authors.lastname: Nedashkivska
authors.forename: Pavel A
authors.initials: PA
authors.lastname: Levkin
mesh_terms: D045744:Cell Line, Tumor; D002469:Cell Separation / Q000295:instrumentation*; D002470:Cell Survival; D060833:Cellular Microenvironment; D004317:Doxorubicin / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D020100:Hydrogels / Q000737:chemistry*; D046210:Microfluidic Analytical Techniques / Q000379:methods*
chemical_list: D020100:Hydrogels; D004317:Doxorubicin