title: Ligand-enabled methylene C(sp3)-H bond activation with a Pd(II) catalyst.
abstract: Pd(II) insertion into β-methylene C(sp(3))-H bonds was enabled by a mutually repulsive and electron-rich quinoline ligand. Ligand tuning led to the development of a method that allows for installation of an aryl group on a range of acyclic and cyclic amides containing β-methylene C(sp(3))-H bonds.
authors.affiliation: Department of Chemistry, The Scripps Research Institute, La Jolla, California 92037, United States.
authors.forename: Masayuki
authors.initials: M
authors.lastname: Wasa
authors.forename: Kelvin S L
authors.initials: KS
authors.lastname: Chan
authors.forename: Xing-Guo
authors.initials: XG
authors.lastname: Zhang
authors.forename: Jian
authors.initials: J
authors.lastname: He
authors.forename: Masanori
authors.initials: M
authors.lastname: Miura
authors.forename: Jin-Quan
authors.initials: JQ
authors.lastname: Yu
mesh_terms: D000577:Amides / Q000138:chemical synthesis* / Q000737:chemistry; D002384:Catalysis; D006860:Hydrogen Bonding; D008024:Ligands; D015394:Molecular Structure; D009942:Organometallic Compounds / Q000737:chemistry*; D010165:Palladium / Q000737:chemistry*; D011725:Pyridines / Q000737:chemistry*; D011804:Quinolines / Q000737:chemistry*
chemical_list: D000577:Amides; D008024:Ligands; D009942:Organometallic Compounds; D011725:Pyridines; D011804:Quinolines; D010165:Palladium