title: Association of rs11190870 near LBX1 with adolescent idiopathic scoliosis susceptibility in a Han Chinese population.
abstract: OBJECTIVE
  To investigate whether rs11190870 near LBX1 correlates with the susceptibility or curve progression of adolescent idiopathic scoliosis (AIS) in a Han Chinese population.
  
  
  METHODS
  A total of 949 AIS patients and 976 age-matched healthy controls were recruited. All the subjects were genotyped using the PCR-based invader assay. Case-control study and case-only study were performed to define the contribution of rs11190870 to predisposition and curve severity of AIS. Additionally, we further conducted a meta-analysis of the study findings together with those of previously reported studies.
  
  
  RESULTS
  A significant association of rs11190870 with AIS was observed in the Han Chinese population (P = 1.8 × 10(-9); odd ratio = 1.51; 95 % confidence interval = 1.33-1.71), and AIS patients with TT genotype had a larger Cobb angle than those with TC or CC genotype (P = 0.005). The meta-analysis confirmed that the positive association of this SNP with AIS in the East Asian population.
  
  
  CONCLUSIONS
  The SNP rs11190870 near LBX1 is associated with both susceptibility and curve progression of AIS.
authors.affiliation: Department of Spine Surgery, The Affiliated Drum Tower Hospital of Nanjing University Medical School, Zhongshan Road No 321, 210008 Nanjing, China.
authors.forename: Hua
authors.initials: H
authors.lastname: Jiang
authors.forename: Xusheng
authors.initials: X
authors.lastname: Qiu
authors.forename: Jin
authors.initials: J
authors.lastname: Dai
authors.forename: Huang
authors.initials: H
authors.lastname: Yan
authors.forename: Zezhang
authors.initials: Z
authors.lastname: Zhu
authors.forename: Bangping
authors.initials: B
authors.lastname: Qian
authors.forename: Yong
authors.initials: Y
authors.lastname: Qiu
mesh_terms: D000293:Adolescent; D000483:Alleles; D044466:Asian People / Q000235:genetics; D016022:Case-Control Studies; D005260:Female; D050939:Gene Fusion; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D005838:Genotype; D018398:Homeodomain Proteins / Q000235:genetics*; D006801:Humans; D008297:Male; D020641:Polymorphism, Single Nucleotide; D011401:Promoter Regions, Genetic; D011859:Radiography; D012600:Scoliosis / Q000000981:diagnostic imaging / Q000235:genetics*; D013131:Spine / Q000000981:diagnostic imaging; D014157:Transcription Factors / Q000235:genetics*
chemical_list: D018398:Homeodomain Proteins; C542809:LBX1 protein, human; D014157:Transcription Factors