title: Dengue hemorrhagic fever and severe thrombocytopenia in a patient on mandatory anticoagulation: balancing two life threatening conditions: a case report.
abstract: BACKGROUND
  Managing a severe dengue infection is a challenge specially when complicated by other comorbidities. We report a patient with dengue haemorrhagic fever and spontaneous bleeding who required mandatory anticoagulation for a prosthetic mitral valve replacement. This is the first case report in published literature describing this therapeutic dilemma.
  
  
  METHODS
  A fifty one year old Sri Lankan woman was diagnosed with dengue haemorrhagic fever with bleeding manifestations. During the critical phase of her illness, the platelet count dropped to 5,000/ɥl. She was also on warfarin 7 mg daily following a prosthetic mitral valve insertion. In managing the patient, the risk of bleeding had to be balanced against the risk of valve thrombosis without anticoagulation. Warfarin was withheld when the platelet count dropped to 100,000/ɥl and restarted when it recovered above 50,000/ɥl. The patient was off anticoagulation for 10 days.
  
  
  CONCLUSIONS
  We managed this patient with close observation and continuous risk benefit assessments of management decisions. However, experience with one patient cannot be generalized to others. Therefore, it is essential that clinicians share their experiences in managing such difficult patients.
authors.affiliation: University Medical Unit, National Hospital of Sri Lanka, Colombo, Sri Lanka.
authors.forename: Champika
authors.initials: C
authors.lastname: Gamakaranage
authors.forename: Chaturaka
authors.initials: C
authors.lastname: Rodrigo
authors.forename: Sincy
authors.initials: S
authors.lastname: Samarawickrama
authors.forename: Dilushi
authors.initials: D
authors.lastname: Wijayaratne
authors.forename: Malaka
authors.initials: M
authors.lastname: Jayawardane
authors.forename: Panduka
authors.initials: P
authors.lastname: Karunanayake
authors.forename: Saroj
authors.initials: S
authors.lastname: Jayasinghe
mesh_terms: D000925:Anticoagulants / Q000008:administration & dosage*; D005260:Female; D019918:Heart Valve Prosthesis Implantation; D006801:Humans; D008875:Middle Aged; D008943:Mitral Valve / Q000601:surgery*; D019595:Severe Dengue / Q000150:complications*; D013188:Sri Lanka; D013921:Thrombocytopenia / Q000150:complications*
chemical_list: D000925:Anticoagulants