title: Identification of tissue-specific targeting peptide.
abstract: Using phage display technique, we identified tissue-targeting peptide sets that recognize specific tissues (bone-marrow dendritic cell, kidney, liver, lung, spleen and visceral adipose tissue). In order to rapidly evaluate tissue-specific targeting peptides, we performed machine learning studies for predicting the tissue-specific targeting activity of peptides on the basis of peptide sequence information using four machine learning models and isolated the groups of peptides capable of mediating selective targeting to specific tissues. As a representative liver-specific targeting sequence, the peptide "DKNLQLH" was selected by the sequence similarity analysis. This peptide has a high degree of homology with protein ligands which can interact with corresponding membrane counterparts. We anticipate that our models will be applicable to the prediction of tissue-specific targeting peptides which can recognize the endothelial markers of target tissues.
authors.affiliation: Insilicotech Co. Ltd., C-602 Korea Bio Park, 694-1, Sampyeong, Bundang-Gu, Seongnam-Shi 463-400, Korea. jungek@insilicotech.co.kr
authors.forename: Eunkyoung
authors.initials: E
authors.lastname: Jung
authors.forename: Nam Kyung
authors.initials: NK
authors.lastname: Lee
authors.forename: Sang-Kee
authors.initials: SK
authors.lastname: Kang
authors.forename: Seung-Hoon
authors.initials: SH
authors.lastname: Choi
authors.forename: Daejin
authors.initials: D
authors.lastname: Kim
authors.forename: Kisoo
authors.initials: K
authors.lastname: Park
authors.forename: Kihang
authors.initials: K
authors.lastname: Choi
authors.forename: Yun-Jaie
authors.initials: YJ
authors.lastname: Choi
authors.forename: Dong Hyun
authors.initials: DH
authors.lastname: Jung
mesh_terms: D000818:Animals; D001185:Artificial Intelligence; D001853:Bone Marrow / Q000378:metabolism*; D003713:Dendritic Cells / Q000378:metabolism*; D008024:Ligands; D008099:Liver / Q000378:metabolism*; D051379:Mice; D008807:Mice, Inbred BALB C; D009928:Organ Specificity; D010446:Peptide Fragments / Q000737:chemistry* / Q000494:pharmacology; D019151:Peptide Library; D011485:Protein Binding; D012372:ROC Curve; D051381:Rats; D017207:Rats, Sprague-Dawley; D017208:Rats, Wistar
chemical_list: D008024:Ligands; D010446:Peptide Fragments; D019151:Peptide Library