title: Di(2-ethylhexyl)phthalate (DEHP) and di-n-butylphthalate (DBP) exposure through diet in hospital patients.
abstract: Ready-to-eat packed meals intended to hospital patients were studied over a two-weeks period to measure the contents of di-(2-ethylhexyl) phthalate (DEHP) and di-n-butylphthalate (DBP) and to evaluate their daily intake by total diet. The packaging consisted of polyethylene terephthalate (PET) dishes sealed with polypropylene (PP) foil. The DEHP mean concentrations in total meals varied from 0.061±0.028 to 0.307±0.138μg/gwetweight (wet wt.); the DBP mean levels varied from 0.025±0.018 to 0.174±0.091μg/gwetwt. Highest levels of concentration for DEHP and DBP were found in bread with mean values of 0.307±0.138μg/gwetwt. and 0.174±0.091μg/gwetwt. for DEHP and DBP, respectively. The daily intake for DEHP was 3.1±0.9μg/kgbw and 1.5±0.5μg/kgbw for DBP. The mean±sd incidence of DEHP and DBP intake via hospital meals on the respective EFSA TDI was 6±2% (range 4-11%), and 15±5% (range 8-24%), respectively. Even if for hospital patients the major route of exposure may be represented by medical devices, the influence of the diet could have a significant value on TDI.
authors.affiliation: Department of Food Science University of Naples "Federico II", Via Università 100, 80055 Portici, Naples, Italy. tcirillo@unina.it
authors.forename: Teresa
authors.initials: T
authors.lastname: Cirillo
authors.forename: Evelina
authors.initials: E
authors.lastname: Fasano
authors.forename: Francesco
authors.initials: F
authors.lastname: Esposito
authors.forename: Paolo
authors.initials: P
authors.lastname: Montuori
authors.forename: Renata
authors.initials: R
authors.lastname: Amodio Cocchieri
mesh_terms: D003993:Dibutyl Phthalate / Q000032:analysis* / Q000633:toxicity; D004032:Diet; D004051:Diethylhexyl Phthalate / Q000032:analysis* / Q000633:toxicity; D004781:Environmental Exposure / Q000032:analysis; D057140:Fast Foods / Q000032:analysis*; D005506:Food Contamination / Q000032:analysis*; D018857:Food Packaging; D006761:Hospitals; D006801:Humans; D007558:Italy; D010361:Patients; D010968:Plasticizers / Q000032:analysis
chemical_list: D010968:Plasticizers; D003993:Dibutyl Phthalate; D004051:Diethylhexyl Phthalate