title: Effect of the yellow passion fruit peel flour (Passiflora edulis f. flavicarpa deg.) in insulin sensitivity in type 2 diabetes mellitus patients.
abstract: BACKGROUND
  A study with the yellow passion fruit peel flour showed positive action in blood glucose control as therapies' adjuvant in patients with type 2 diabetes mellitus. Therefore, we evaluated its effect on insulin sensitivity since there is a quest for studies that focus at better understanding of insulin resistance aspects in diabetic patients. Furthermore its relationship with chronic complications can also give good prospects for alternative treatments.
  
  
  METHODS
  A total of 43 type 2 diabetes volunteers (28 females and 15 males) ingested 30 g/day of the yellow passion fruit peel flour for two months. The levels of blood glucose and fasting insulin, HOMA index and glycated hemoglobin were measured for each patient before and after dietary supplementation.
  
  
  RESULTS
  There was a significant difference in the fasting blood glucose values (P = 0.000) and glycated hemoglobin (P = 0.032) after supplementation. It was also seen a reduction in HOMA IR (P = 0.005) in the supplemented group, however it was not observed changes in insulin values for females. HOMA beta (P = 0.000) showed significant increase in its values for the studied group.
  
  
  CONCLUSIONS
  The supplementation used decreased insulin resistance in type 2 diabetic patients, suggesting a positive action in blood glucose control as adjuvant therapy in conventional treatments.
authors.affiliation: Department of Pharmacy, Paraíba State University, 58429-600, Campina Grande, PB, Brazil. queirozsocorroramos@yahoo.com.br
authors.forename: Maria do Socoro Ramos
authors.initials: Mdo S
authors.lastname: de Queiroz
authors.forename: Daniele Idalino
authors.initials: DI
authors.lastname: Janebro
authors.forename: Maria Auxiliadora Lins
authors.initials: MA
authors.lastname: da Cunha
authors.forename: Josimar dos Santos
authors.initials: Jdos S
authors.lastname: Medeiros
authors.forename: Armando U O
authors.initials: AU
authors.lastname: Sabaa-Srur
authors.forename: Margareth de Fatima F M
authors.initials: Mde F
authors.lastname: Diniz
authors.forename: Silvana Cristina
authors.initials: SC
authors.lastname: Dos Santos
mesh_terms: D000368:Aged; D015992:Body Mass Index; D001938:Brazil; D003131:Combined Modality Therapy; D003924:Diabetes Mellitus, Type 2 / Q000150:complications / Q000178:diet therapy* / Q000188:drug therapy / Q000378:metabolism; D004043:Dietary Fiber / Q000627:therapeutic use; D019587:Dietary Supplements; D004359:Drug Therapy, Combination; D005260:Female; D005638:Fruit / Q000737:chemistry*; D006442:Glycated Hemoglobin / Q000032:analysis; D006801:Humans; D006943:Hyperglycemia / Q000517:prevention & control*; D007004:Hypoglycemic Agents / Q000627:therapeutic use*; D007333:Insulin Resistance; D008297:Male; D008875:Middle Aged; D050177:Overweight / Q000150:complications; D029598:Passiflora / Q000737:chemistry*; D012727:Sex Characteristics
chemical_list: D004043:Dietary Fiber; D006442:Glycated Hemoglobin; D007004:Hypoglycemic Agents; C517652:hemoglobin A1c protein, human