title: Low-volume exercise training attenuates oxidative stress and neutrophils activation in older adults.
abstract: The purpose of this study was to investigate the effects of low-volume exercise training (100 min/week) on oxidative stress and neutrophils activation markers in older adults. Twenty-eight older adults (age range 65-78 years) were assigned into control (n = 14) or exercise (n = 14) groups. The exercise program consisted of walking 30-60 min/session, 2 days each week for 12 weeks. Blood samples were taken before starting the sessions (baseline) and when they ended. Fasting plasma and serum oxidative stress and inflammatory markers were measured using commercial kits. Cell surface expression of adhesion molecules on circulating leukocytes (CD66b and CD62L) was determined using flow cytometry. The concentrations of derivatives of reactive oxygen metabolites tended to be lower than the baseline values only in the exercise group (P = 0.05). The biological antioxidant potential, thioredoxin concentrations, and glutathione peroxidase activities significantly increased only in the exercise group (P < 0.05 for all). While CD66b expression tended to decrease only in the exercise group, CD62L expression significantly increased (P < 0.05). Our findings indicate that exercise training below the current recommended level of at least 150 min/week attenuates basal oxidative stress and neutrophil activation in older adults. Thus, our findings may encourage more people to incorporate a small amount of physical activity into their lives.
authors.affiliation: Graduate School of Sport Sciences, Waseda University, Tokorozawa, Saitama, Japan.
authors.forename: Masaki
authors.initials: M
authors.lastname: Takahashi
authors.forename: Masashi
authors.initials: M
authors.lastname: Miyashita
authors.forename: Noriaki
authors.initials: N
authors.lastname: Kawanishi
authors.forename: Jong-Hwan
authors.initials: JH
authors.lastname: Park
authors.forename: Harumi
authors.initials: H
authors.lastname: Hayashida
authors.forename: Hyun-Shik
authors.initials: HS
authors.lastname: Kim
authors.forename: Yoshio
authors.initials: Y
authors.lastname: Nakamura
authors.forename: Shizuo
authors.initials: S
authors.lastname: Sakamoto
authors.forename: Katsuhiko
authors.initials: K
authors.lastname: Suzuki
mesh_terms: D000368:Aged; D015703:Antigens, CD / Q000097:blood; D016022:Case-Control Studies; D015815:Cell Adhesion Molecules / Q000097:blood; D015444:Exercise; D005260:Female; D006801:Humans; D019041:L-Selectin / Q000097:blood; D008297:Male; D018375:Neutrophil Activation; D018384:Oxidative Stress; D016138:Walking
chemical_list: D015703:Antigens, CD; C069847:CD66 antigens; D015815:Cell Adhesion Molecules; D019041:L-Selectin