title: Relationship between mechanical properties and bone mineral density of human femoral bone retrieved from patients with osteoarthritis.
abstract: The objective of this study was to analyse retrieved human femoral bone samples using three different test methods, to elucidate the relationship between bone mineral density and mechanical properties. Human femoral heads were retrieved from 22 donors undergoing primary total hip replacement due to hip osteoarthritis and stored for a maximum of 24 hours postoperatively at + 6 °C to 8 °C.Analysis revealed an average structural modulus of 232±130 N/mm(2) and ultimate compression strength of 6.1±3.3 N/mm(2) with high standard deviations. Bone mineral densities of 385±133 mg/cm(2) and 353±172 mg/cm(3) were measured using thedual energy X-ray absorptiometry (DXA) and quantitative computed tomography (QCT), respectively. Ashing resulted in a bone mineral density of 323±97 mg/cm(3). In particular, significant linear correlations were found between DXA and ashing with r = 0.89 (p < 0.01, n = 22) and between structural modulus and ashing with r = 0.76 (p < 0.01, n = 22).Thus, we demonstrated a significant relationship between mechanical properties and bone density. The correlations found can help to determine the mechanical load capacity of individual patients undergoing surgical treatments by means of noninvasive bone density measurements.
authors.affiliation: Department of Orthopaedics, Biomechanics and Implant Technology Research Laboratory, University Medicine Rostock, Germany.
authors.forename: Yvonne
authors.initials: Y
authors.lastname: Haba
authors.forename: Tobias
authors.initials: T
authors.lastname: Lindner
authors.forename: Andreas
authors.initials: A
authors.lastname: Fritsche
authors.forename: Ann-Kristin
authors.initials: AK
authors.lastname: Schiebenhöfer
authors.forename: Robert
authors.initials: R
authors.lastname: Souffrant
authors.forename: Daniel
authors.initials: D
authors.lastname: Kluess
authors.forename: Ralf
authors.initials: R
authors.lastname: Skripitz
authors.forename: Wolfram
authors.initials: W
authors.lastname: Mittelmeier
authors.forename: Rainer
authors.initials: R
authors.lastname: Bader
keywords: Human trabecular bone; bone mineral density; femoral head; mechanical properties.