title: Treatment of experimental ulcerative colitis.
abstract: The effects of infliximab, an anticytokine drug, on the course of inflammatory process was studied on the model of ulcerative colitis induced by injection of picrylsulfonic acid. Infliximab prevented the development of toxic dilatation and a drop of bioelectric activity of smooth muscles via maintenance of activity of the intramural nervous system neurons.
authors.affiliation: Institute of Gastroenterology, Moscow, Russia.
authors.forename: L B
authors.initials: LB
authors.lastname: Lazebnik
authors.forename: A E
authors.initials: AE
authors.lastname: Lychkova
authors.forename: O V
authors.initials: OV
authors.lastname: Knyazev
mesh_terms: D000200:Action Potentials / Q000187:drug effects / Q000502:physiology; D000818:Animals; D000911:Antibodies, Monoclonal / Q000494:pharmacology / Q000627:therapeutic use*; D002432:Cecum / Q000187:drug effects* / Q000473:pathology; D003093:Colitis, Ulcerative / Q000139:chemically induced / Q000188:drug therapy* / Q000473:pathology; D003106:Colon / Q000187:drug effects* / Q000473:pathology; D004566:Electrodes; D005765:Gastrointestinal Agents / Q000494:pharmacology / Q000627:therapeutic use*; D007082:Ileum / Q000187:drug effects* / Q000473:pathology; D000069285:Infliximab; D009130:Muscle, Smooth / Q000187:drug effects* / Q000473:pathology; D051381:Rats; D017208:Rats, Wistar; D016896:Treatment Outcome; D014302:Trinitrobenzenesulfonic Acid
chemical_list: D000911:Antibodies, Monoclonal; D005765:Gastrointestinal Agents; D014302:Trinitrobenzenesulfonic Acid; D000069285:Infliximab