title: Mechanosynthesis of amides in the total absence of organic solvent from reaction to product recovery.
abstract: The synthesis of various amides has been realised avoiding the use of any organic solvent from activation of carboxylic acids with CDI to isolation of the amides. Mechanochemistry was the key point of the process allowing rapid formation of the amide bond and efficient water-based purification of the final products.
authors.affiliation: Institut des Biomolécules Max Mousseron, UMR 5247 Université Montpellier 1 et Université Montpellier 2-CNRS, Place Eugène Bataillon, 34095 Montpellier Cedex 05, France. txmetro@um2.fr
authors.forename: Thomas-Xavier
authors.initials: TX
authors.lastname: Métro
authors.forename: Julien
authors.initials: J
authors.lastname: Bonnamour
authors.forename: Thomas
authors.initials: T
authors.lastname: Reidon
authors.forename: Jordi
authors.initials: J
authors.lastname: Sarpoulet
authors.forename: Jean
authors.initials: J
authors.lastname: Martinez
authors.forename: Frédéric
authors.initials: F
authors.lastname: Lamaty
mesh_terms: D000577:Amides / Q000138:chemical synthesis* / Q000737:chemistry; D002264:Carboxylic Acids / Q000737:chemistry*; D007093:Imidazoles / Q000737:chemistry*; D014867:Water / Q000737:chemistry
chemical_list: D000577:Amides; D002264:Carboxylic Acids; D007093:Imidazoles; D014867:Water; C006900:N,N-carbonyldiimidazole