title: The role of promoter hypermethylation in fibroblast activation and fibrogenesis.
abstract: The aberrant methylation of CpG island promoters of selected genes is the prominent epigenetic mechanism by which gene transcription can be effectively silenced. Aberrant hypermethylation of a few selected genes plays an important role in facilitating fibrotic fibroblast activation and in driving fibrogenesis. Here we review mechanisms of DNA methylation and demethylation and their implications for fibroblast activation and tissue fibrosis.
authors.affiliation: Department of Cardiology and Pneumology, Göttingen University Medical Centre, Georg August University, Göttingen, Germany.
authors.forename: Elisabeth M
authors.initials: EM
authors.lastname: Zeisberg
authors.forename: Michael
authors.initials: M
authors.lastname: Zeisberg
mesh_terms: D000818:Animals; D018899:CpG Islands; D019175:DNA Methylation; D044127:Epigenesis, Genetic; D005347:Fibroblasts / Q000378:metabolism* / Q000473:pathology; D005355:Fibrosis; D005786:Gene Expression Regulation; D020868:Gene Silencing; D006801:Humans; D007668:Kidney / Q000378:metabolism* / Q000473:pathology; D007674:Kidney Diseases / Q000235:genetics* / Q000378:metabolism / Q000473:pathology; D011401:Promoter Regions, Genetic; D020703:ras GTPase-Activating Proteins / Q000235:genetics
chemical_list: D020703:ras GTPase-Activating Proteins