title: "η6"-Type anion-π in biomolecular recognition.
abstract: Theoretical and compelling experimental evidence indicates that the interaction between an anion and an aromatic π system when the anion is directly above the ring face ("η(6)"-type anion-π), can be attractive. This may play an important role in the formation and recognition of biomolecular structures. We examined high-resolution structures of proteins and nucleic acids for the presence of "η(6)"-type anion-π. Though less frequent than its counterpart cation-π, "η(6)"-type anion-π is observed unambiguously, occurring in protein/nucleic acid loops and often involving conserved/coevolving sites in proteins, suggesting it plays an important role in macromolecular folding and function.
authors.affiliation: Department of Chemistry and Biochemistry, South Dakota State University, Brookings, SD 57007, USA. suvobrata.chakravarty@sdstate.edu
authors.forename: Suvobrata
authors.initials: S
authors.lastname: Chakravarty
authors.forename: Zi-Zhang
authors.initials: ZZ
authors.lastname: Sheng
authors.forename: Bradley
authors.initials: B
authors.lastname: Iverson
authors.forename: Brian
authors.initials: B
authors.lastname: Moore
mesh_terms: D000838:Anions; D009696:Nucleic Acids / Q000737:chemistry*; D011506:Proteins / Q000737:chemistry*
chemical_list: D000838:Anions; D009696:Nucleic Acids; D011506:Proteins