title: Ectopically expressed IBP promotes cell proliferation in oral squamous cell carcinoma.
abstract: IFN regulatory factor 4 binding protein (IBP) has been shown to play an important role in the progression of malignant tumors such as breast cancer cells, but its function in oral squamous cell carcinoma (OSCC) remains unclear. We found that IBP ectopically expressed in some OSCC specimens but not in normal oral mucosa epithelium tissues. IBP expression was significantly correlated with tumor size, differentiation, clinical stage, and distant metastasis. Furthermore, IBP markedly promoted OSCC cell proliferation, shortened the G1 interval in the cell cycle, and increased cyclin D1 expression. These findings suggest that IBP may be a potential therapeutic target for OSCC.
authors.affiliation: Department of Clinical Biochemistry, Laboratory Sciences, the Third Military Medical University, Chongqing, PR China.
authors.forename: Cong-Xiang
authors.initials: CX
authors.lastname: Jian
authors.forename: Ming-Zhen
authors.initials: MZ
authors.lastname: Yang
authors.forename: Peng
authors.initials: P
authors.lastname: Li
authors.forename: Jian
authors.initials: J
authors.lastname: Xiong
authors.forename: Zhu-Jun
authors.initials: ZJ
authors.lastname: Zhang
authors.forename: Chen-Jun
authors.initials: CJ
authors.lastname: Li
authors.forename: An
authors.initials: A
authors.lastname: Chen
authors.forename: Chuan-Min
authors.initials: CM
authors.lastname: Hu
authors.forename: Ji-Xiang
authors.initials: JX
authors.lastname: Zhou
authors.forename: Shu-Hui
authors.initials: SH
authors.lastname: Li
mesh_terms: D000818:Animals; D014408:Biomarkers, Tumor / Q000819:agonists*; D015153:Blotting, Western; D002294:Carcinoma, Squamous Cell / Q000378:metabolism* / Q000473:pathology*; D045744:Cell Line, Tumor; D049109:Cell Proliferation; D004268:DNA-Binding Proteins / Q000096:biosynthesis*; D005260:Female; D005434:Flow Cytometry; D005455:Fluorescent Antibody Technique; D020662:Guanine Nucleotide Exchange Factors / Q000096:biosynthesis*; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D009062:Mouth Neoplasms / Q000378:metabolism* / Q000473:pathology*; D009367:Neoplasm Staging; D009687:Nuclear Proteins / Q000096:biosynthesis*; D046888:Tissue Array Analysis; D014162:Transfection; D014183:Transplantation, Heterologous
chemical_list: D014408:Biomarkers, Tumor; C479750:DEF6 protein, human; D004268:DNA-Binding Proteins; D020662:Guanine Nucleotide Exchange Factors; D009687:Nuclear Proteins