title: Experimental study on anti-tumor and anti-inflammatory effect of Thespesia populnea phytochemical extract in mice models.
abstract: In the present study, we have conducted a dose- and duration-dependent response of phytochemical extract of Thespesia populnea (Malvaceae) plant native of costal forest of India. Our earlier studies revealed the anti-oxidant and chemoprotective effect of this plant extract. In the present study, we have attempted to study the anti-tumor and anti-inflammatory response of T. populnea using experimental mouse models. Our studies revealed that administration of T. populnea methanol extract was shown to inhibit the solid tumor development in mice. T. populnea treatment significantly reduced tumor cell glutathione (GSH) levels as well as serum γ-glutamyl transpeptidase (GGT) and nitric oxide (NO) levels in the tumor-bearing animals (p < 0.01). The total white blood cell count and hemoglobin levels were also significantly increased in extract-treated hosts (p < 0.05, p < 0.01). The use of T. populnea substantially reduced the acute inflammation (assessed as paw edema) induced by carrageenan and also reduced inflammation edema induced by formalin. These studies suggest that T. populnea extract could be used as a (natural) anti-inflammatory and anti-tumor agent.
authors.affiliation: Department of Biotechnology, School of Biotechnology and Health Sciences, Karunya University, Karunya Nagar, Coimbatore, TN, India.
authors.forename: Denish
authors.initials: D
authors.lastname: Mika
authors.forename: C
authors.initials: C
authors.lastname: Guruvayoorappan
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology*; D000970:Antineoplastic Agents / Q000494:pharmacology*; D002351:Carrageenan; D045744:Cell Line, Tumor; D004487:Edema / Q000139:chemically induced / Q000188:drug therapy*; D005978:Glutathione / Q000378:metabolism; D006454:Hemoglobins / Q000187:drug effects; D007194:India; D019660:Malvaceae / Q000737:chemistry*; D008546:Melanoma, Experimental / Q000188:drug therapy*; D051379:Mice; D008807:Mice, Inbred BALB C; D009569:Nitric Oxide / Q000378:metabolism; D008517:Phytotherapy / Q000379:methods; D010936:Plant Extracts / Q000494:pharmacology*; D005723:gamma-Glutamyltransferase / Q000097:blood
chemical_list: D000893:Anti-Inflammatory Agents; D000970:Antineoplastic Agents; D006454:Hemoglobins; D010936:Plant Extracts; D009569:Nitric Oxide; D002351:Carrageenan; D005723:gamma-Glutamyltransferase; D005978:Glutathione