title: Trimethoprim-sulfamethoxazole-induced Steven Johnson syndrome in an HIV-infected patient.
abstract: Trimethoprim-sulfamethoxazole (TMP/SMX) is a widely prescribed antimicrobial for the management of several uncomplicated infections. It is commonly used for the treatment and prophylaxis of Pneumocystis jirovecii pneumonia (PCP) in the HIV-infected population. The adverse reaction to TMP/SMX is more frequent and severe in HIV-infected patients as compared to the general population. Here, we report a case of Stevens-Johnson syndrome (SJS) secondary to TMP/SMX. The patient had a generalized cutaneous reaction with involvement of the eyes, oral cavity, and genitals. He had elevated hepatic alanine aminotransferase and aspartate aminotransferase enzyme. TMP/SMX therapy was stopped and supportive treatment was started. His condition improved after eight days of stopping TMP/SMX therapy.
authors.affiliation: Department of Oral Pathology and Microbiology, Bharthi Vidyapeeth University Dental College and Hospital, Navi Mumbai, India.
authors.forename: Syed Ahmed
authors.initials: SA
authors.lastname: Taqi
authors.forename: Syed Ahmed
authors.initials: SA
authors.lastname: Zaki
authors.forename: Angadi Rajasab
authors.initials: AR
authors.lastname: Nilofer
authors.forename: Lateef Begum
authors.initials: LB
authors.lastname: Sami
mesh_terms: D000328:Adult; D000890:Anti-Infective Agents / Q000009:adverse effects; D015658:HIV Infections / Q000150:complications / Q000188:drug therapy*; D006801:Humans; D008297:Male; D013262:Stevens-Johnson Syndrome / Q000139:chemically induced* / Q000150:complications / Q000175:diagnosis*; D015662:Trimethoprim, Sulfamethoxazole Drug Combination / Q000009:adverse effects*
chemical_list: D000890:Anti-Infective Agents; D015662:Trimethoprim, Sulfamethoxazole Drug Combination
keywords: Desensitization; HIV infection; P. jirovecii pneumonia; Steven Johnson syndrome; glutathione enzyme; trimethoprim-sulfamethoxazole