title: Quantification of the dynamics of enterovirus 71 infection by experimental-mathematical investigation.
abstract: Enterovirus 71 (EV71) is the causative agent of hand-foot-and-mouth disease and can trigger neurological disorders. EV71 outbreaks are a major public health concern in Asia-Pacific countries. By performing experimental-mathematical investigation, we demonstrate here that viral productivity and transmissibility but not viral cytotoxicity are drastically different among EV71 strains and can be associated with their epidemiological backgrounds. This is the first report demonstrating the dynamics of nonenveloped virus replication in cell culture using mathematical modeling.
authors.affiliation: Graduate School of Biostudies, Kyoto University, Kyoto, Japan.
authors.forename: Mitsuko
authors.initials: M
authors.lastname: Fukuhara
authors.forename: Shingo
authors.initials: S
authors.lastname: Iwami
authors.forename: Kei
authors.initials: K
authors.lastname: Sato
authors.forename: Yorihiro
authors.initials: Y
authors.lastname: Nishimura
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Shimizu
authors.forename: Kazuyuki
authors.initials: K
authors.lastname: Aihara
authors.forename: Yoshio
authors.initials: Y
authors.lastname: Koyanagi
mesh_terms: D001208:Asia / Q000453:epidemiology; D004196:Disease Outbreaks; D029821:Enterovirus A, Human / Q000472:pathogenicity*; D006232:Hand, Foot and Mouth Disease / Q000453:epidemiology* / Q000821:virology*; D006801:Humans; D008962:Models, Theoretical