title: Gender-related differences of diabetic patients undergoing percutaneous coronary intervention with drug-eluting stents: a real-life multicenter experience.
abstract: BACKGROUND
  Gender-based differences in diabetic patients are understudied in the field of percutaneous coronary intervention (PCI) with drug-eluting stents.
  
  
  METHODS
  Data were obtained from a multicenter registry of 2420 consecutive patients with diabetes mellitus (DM) who underwent PCI with paclitaxel- or sirolimus-eluting stents between 2003 and 2009. Among them, 679 (28.1%) women were compared to 1741 (71.9%) men in terms of clinical aspects and major adverse cardiac events (MACE), including all-cause death, myocardial infarction (MI) and target lesion revascularization (TLR). Target vessel revascularization (TVR) and any revascularization were also reported.
  
  
  RESULTS
  Women were less numerous, older, used more insulin and showed more tortuous coronary arteries, while men were more frequently smokers and received larger stents. At the median follow-up of 24.3 months (interquartile range 12.3-39.7), MACE, TVR and any revascularization did not significantly differ between females and males (19.9% vs 18.7%, 12.2% vs 13.4%, 14.1% vs 15.1%, respectively). At multivariable analysis of the overall cohort, female gender was not a predictor of MACE (hazard ratio [HR] 1.02, 95% confidence interval [CI] 0.92-2.36, p=0.11), death (HR 1.04, 95% CI 0.84-1.24, p=0.86), MI (HR 1.48, 95% CI 0.92-2.36, p=0.11), and TLR (HR 1.14, 95% CI 0.85-1.52, p=0.38).
  
  
  CONCLUSIONS
  In this registry of diabetic patients treated by drug-eluting stents, women were less represented, older and needed more insulin compared to men who, on the other hand, received larger stents. Gender-related outcomes were similar and female sex did not predict MACE.
authors.affiliation: Department of Cardiac, Thoracic and Vascular Sciences, University of Padua Medical School, Padua, Italy.
authors.forename: Paolo
authors.initials: P
authors.lastname: Buja
authors.forename: Gianpiero
authors.initials: G
authors.lastname: D'Amico
authors.forename: Michela
authors.initials: M
authors.lastname: Facchin
authors.forename: Alberto
authors.initials: A
authors.lastname: Barioli
authors.forename: Massimo
authors.initials: M
authors.lastname: Napodano
authors.forename: Davide
authors.initials: D
authors.lastname: Capodanno
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Musumeci
authors.forename: Anna Chiara
authors.initials: AC
authors.lastname: Frigo
authors.forename: Francesco
authors.initials: F
authors.lastname: Saia
authors.forename: Alberto
authors.initials: A
authors.lastname: Menozzi
authors.forename: Mauro
authors.initials: M
authors.lastname: De Benedictis
authors.forename: Michael S
authors.initials: MS
authors.lastname: Lee
authors.forename: Corrado
authors.initials: C
authors.lastname: Lettieri
authors.forename: Corrado
authors.initials: C
authors.lastname: Tamburino
authors.forename: Gennaro
authors.initials: G
authors.lastname: Sardella
authors.forename: Giambattista
authors.initials: G
authors.lastname: Isabella
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Tarantini
mesh_terms: D000368:Aged; D015331:Cohort Studies; D003920:Diabetes Mellitus / Q000175:diagnosis / Q000503:physiopathology* / Q000601:surgery*; D054855:Drug-Eluting Stents; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D062645:Percutaneous Coronary Intervention / Q000379:methods; D011446:Prospective Studies; D012042:Registries; D012189:Retrospective Studies; D012727:Sex Characteristics
keywords: Diabetes mellitus; Drug-eluting stents; Gender; Outcome