title: Fluorescence spectra of blood and urine for cervical cancer detection.
abstract: In the current study, the fluorescence emission spectra (FES) and Stokes shift spectra (SSS) of blood and urine samples of cervical cancer patients were obtained and compared to those of normal controls. Both spectra showed that the relative intensity of biomolecules such as porphyrin, collagen, Nicotinamide adenine dinucleotide, and flavin were quite out of proportion in cervical cancer patients. The biochemical mechanism for the elevation of these fluorophores is not yet definitive; nevertheless, these biomolecules could serve as tumor markers for diagnosis, screening, and follow-up of cervical cancers. To the best of our knowledge, this is the first report on FES and SSS of blood and urine of cervical cancer patients to give a sensitivity of 80% and specificity of 78%.
authors.affiliation: King Saud University, College Of Science, Department of Physics and Astronomy, P.O. Box 2455, Riyadh, Kingdom of Saudi Arabia.
authors.forename: Vadivel
authors.initials: V
authors.lastname: Masilamani
authors.forename: Mohamad Saleh
authors.initials: MS
authors.lastname: Alsalhi
authors.forename: Trinka
authors.initials: T
authors.lastname: Vijmasi
authors.forename: Kanaganaj
authors.initials: K
authors.lastname: Govindarajan
authors.forename: Ram
authors.initials: R
authors.lastname: Rathan Rai
authors.forename: Muhammad
authors.initials: M
authors.lastname: Atif
authors.forename: Saradh
authors.initials: S
authors.lastname: Prasad
authors.forename: Abdullah S
authors.initials: AS
authors.lastname: Aldwayyan
mesh_terms: D014408:Biomarkers, Tumor / Q000097:blood* / Q000652:urine*; D005260:Female; D006801:Humans; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D013050:Spectrometry, Fluorescence / Q000379:methods*; D002583:Uterine Cervical Neoplasms / Q000175:diagnosis* / Q000378:metabolism*
chemical_list: D014408:Biomarkers, Tumor