title: Developing nanotherapies for neurodegenerative diseases: ORMOSIL and its potential in axonal transport.
abstract: In neurons, essential components packaged into vesicles are transported down microtubules to the ends of axons (synapses) where they are utilized. Components are also transported from the synapse to the cell body. This transport pathway is crucial for normal development, cell survival and plasticity. Recent work has established that defects in transport can contribute to the initiation of neurodegenerative disease, culminating in cell death and degeneration. Thus, delivering therapeutic treatments to an early defect is critical since many current strategies target pathology that occurs at later stages in the disease. Current treatments also affect the entire organism, causing side-effects that are often more deleterious than the disease. This article discusses how engineered synthetic structures can be used to directly target axonal transport--a pathway that is affected during the early stages of disease. Studies in this area will require the exchange of fundamental knowledge between biologists, chemists and engineers to effectively manufacture novel biomaterials for medical use.
authors.affiliation: Department of Biological Sciences, The State University of New York at Buffalo, Buffalo, NY 14260, USA. sg99@buffalo.edu
authors.forename: Shermali
authors.initials: S
authors.lastname: Gunawardena
mesh_terms: D000818:Animals; D001370:Axonal Transport; D016503:Drug Delivery Systems; D015195:Drug Design; D006801:Humans; D008870:Microtubules / Q000378:metabolism; D053758:Nanoparticles; D019636:Neurodegenerative Diseases / Q000188:drug therapy* / Q000503:physiopathology; D012833:Siloxanes / Q000737:chemistry*
chemical_list: D012833:Siloxanes; C510784:ormosil