title: How low is low enough? Evaluation of various risk-assessment models for lymph node metastasis in endometrial cancer: a Korean multicenter study.
abstract: OBJECTIVE
  The aim of this study was to identify a standard for the evaluation of future models for prediction of lymph node metastasis in endometrial cancer through estimation of performance of well-known surgicopathological models.
  
  
  METHODS
  Using the medical records of 947 patients with endometrial cancer who underwent surgical management with lymphadenectomy, we retrospectively assessed the predictive performances of nodal metastasis of currently available models.
  
  
  RESULTS
  WE EVALUATED THREE MODELS INCLUDED: 1) a model modified from the Gynecologic Oncology Group (GOG) pilot study; 2) one from the GOG-33 data; and 3) one from Mayo Clinic data. The three models showed similar negative predictive values ranging from 97.1% to 97.4%. Using Bayes' theorem, this can be translated into 2% of negative post-test probability when 10% of prevalence of lymph node metastasis was assumed. In addition, although the negative predictive value was similar among these models, the proportion that was classified as low-risk was significantly different between the studies (56.4%, 44.8%, and 30.5%, respectively; p<0.001).
  
  
  CONCLUSIONS
  The current study suggests that a false negativity of 2% or less should be a goal for determining clinical usefulness of preoperative or intraoperative prediction models for low-risk of nodal metastasis.
authors.affiliation: Center for Uterine Cancer, National Cancer Center, Goyang, Korea.
authors.forename: Sokbom
authors.initials: S
authors.lastname: Kang
authors.forename: Jong-Min
authors.initials: JM
authors.lastname: Lee
authors.forename: Jae-Kwan
authors.initials: JK
authors.lastname: Lee
authors.forename: Jae Weon
authors.initials: JW
authors.lastname: Kim
authors.forename: Chi-Heum
authors.initials: CH
authors.lastname: Cho
authors.forename: Seok-Mo
authors.initials: SM
authors.lastname: Kim
authors.forename: Sang-Yoon
authors.initials: SY
authors.lastname: Park
authors.forename: Chan-Yong
authors.initials: CY
authors.lastname: Park
authors.forename: Ki-Tae
authors.initials: KT
authors.lastname: Kim
keywords: Endometrial cancer; Low-risk group; Lymph node dissection; Lymphadenectomy; Prediction; Sensitivity and specificity