title: [Wilson's disease: clinical spectrum of liver disease].
abstract: Wilson's disease is a hereditary autosomal recessive disorder of copper metabolism,characterized by copper accumulation in the liver and brain. This rare entity, which has a broad clinical spectrum, is often difficult to diagnose and should therefore always be suspected in patients with liver disease of unclear cause. We describe two types of manifestation of liver disease in two patients; the first developed fulminant hepatic failure requiring urgent liver transplantation and the second showed advanced chronic liver disease and received standard medical treatment. The objective of this clinical observation is to analyze the diagnosis of Wilson's disease in two patients with distinct onset, illustrating the broad clinical spectrum of the disease, and its treatment.
authors.affiliation: Sección de Hepatología, Servicio de Aparato Digestivo, Hospital General Universitario Gregorio Marañón, Madrid, España.
authors.forename: Alejandra
authors.initials: A
authors.lastname: Ochoa Palominos
authors.forename: Luis
authors.initials: L
authors.lastname: Ibáñez Samaniego
authors.forename: María-Vega
authors.initials: MV
authors.lastname: Catalina Rodríguez
authors.forename: José
authors.initials: J
authors.lastname: Pajares Díaz
authors.forename: Gerardo
authors.initials: G
authors.lastname: Clemente Ricote
mesh_terms: D000328:Adult; D003300:Copper; D005260:Female; D006527:Hepatolenticular Degeneration / Q000175:diagnosis*; D006801:Humans; D008107:Liver Diseases / Q000175:diagnosis; D008875:Middle Aged
chemical_list: D003300:Copper