title: Bicluster and pathway enrichment analysis of HCV-induced cirrhosis and hepatocellular carcinoma.
abstract: BACKGROUND
  Hepatocellular carcinoma (HCC) is the sixth most common cancer worldwide and the most common form of liver cancer. However, while it is associated frequently with hepatitis C virus (HCV) there is only an elementary understanding of its molecular pathogenesis.
  
  
  METHODS
  To gain insight into the molecular mechanisms of HCV-induced hepatocarcinogenesis, we performed microarray analysis on 75 surgical liver samples from 48 HCV-infected patients.
  
  
  RESULTS
  There were 395 differentially expressed genes between cirrhotic samples and HCC samples. Of these, 125 genes were up-regulated and 270 genes were down-regulated. We performed pathway enrichment analysis and screened as described previously.
  
  
  CONCLUSIONS
  The differentially expressed genes might be involved in hepatocarcinogenesis through upregulating the pathways of ECM-receptor interaction, focal adhesion, cell adhesion molecules and other cancer-related pathways, and downregulating the pathways of "complement and coagulation cascades". We hope our results could aid in seeking of therapeutic targets for HCV-induced hepatocellular carcinoma.
authors.affiliation: Department of Oncology, PLA general hospital of Chengdu Commond, Clinical Medical College of The Third Medical Military University, Chengdu, China.
authors.forename: Peng
authors.initials: P
authors.lastname: Cheng
authors.forename: You
authors.initials: Y
authors.lastname: Cheng
authors.forename: Mei X
authors.initials: MX
authors.lastname: Su
authors.forename: Dong
authors.initials: D
authors.lastname: Li
authors.forename: Guo Z
authors.initials: GZ
authors.lastname: Zhao
authors.forename: Hui
authors.initials: H
authors.lastname: Gao
authors.forename: Yan
authors.initials: Y
authors.lastname: Li
authors.forename: Jie Y
authors.initials: JY
authors.lastname: Zhu
authors.forename: Hua
authors.initials: H
authors.lastname: Li
authors.forename: Tao
authors.initials: T
authors.lastname: Zhang
mesh_terms: D014408:Biomarkers, Tumor / Q000235:genetics*; D006528:Carcinoma, Hepatocellular / Q000209:etiology* / Q000473:pathology; D016000:Cluster Analysis; D019295:Computational Biology; D020869:Gene Expression Profiling; D015972:Gene Expression Regulation, Neoplastic; D016174:Hepacivirus / Q000235:genetics*; D006526:Hepatitis C / Q000150:complications* / Q000821:virology; D006801:Humans; D008103:Liver Cirrhosis / Q000209:etiology* / Q000473:pathology; D008113:Liver Neoplasms / Q000209:etiology* / Q000473:pathology; D020411:Oligonucleotide Array Sequence Analysis
chemical_list: D014408:Biomarkers, Tumor