title: The combination of mitochondrial low enzyme-activity aldehyde dehydrogenase 2 allele and superoxide dismutase 2 genotypes increases the risk of hypertension in relation to alcohol consumption.
abstract: A cooperative role of mitochondrial aldehyde dehydrogenase 2 (ALDH2) and superoxide dismutase 2 (SOD2) to maintain the vascular function has recently been demonstrated in nitrate tolerance. The present study examined whether the combination of low enzyme-activity variants of ALDH2 and SOD2 increases the risk of hypertension in relation to alcohol consumption. A total of 444 Japanese participants in a health-screening program were evaluated. The risk of hypertension among the individuals harboring both the ALDH2*2 allele and the SOD2 Val/Val genotype was significantly higher in drinkers than in nondrinkers (adjusted odds ratio, 6.22; 95% confidence interval, 2.26-17.1; P<0.001). Among these individuals, the systolic/diastolic blood pressure also increased by 0.24/0.14 mmHg for each 1g/day increase in alcohol consumption (P<0.001/P=0.003). These associations were observed, but the degree was lower among those with the other genotype combinations (0.11/0.10 mmHg; P=0.012/P=0.001). Information about the genetic predisposition to alcohol-related diseases may thus be useful to promote lifestyle modifications for high-risk individuals.
authors.affiliation: Division of Pharmacology and Therapeutics, Graduate School of Pharmaceutical Sciences, Kumamoto University, Kumamoto, Japan.
authors.forename: Takehiro
authors.initials: T
authors.lastname: Nakagawa
authors.forename: Ayami
authors.initials: A
authors.lastname: Kajiwara
authors.forename: Junji
authors.initials: J
authors.lastname: Saruwatari
authors.forename: Ai
authors.initials: A
authors.lastname: Hamamoto
authors.forename: Wataru
authors.initials: W
authors.lastname: Kaku
authors.forename: Kentaro
authors.initials: K
authors.lastname: Oniki
authors.forename: Shuichi
authors.initials: S
authors.lastname: Mihara
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Ogata
authors.forename: Kazuko
authors.initials: K
authors.lastname: Nakagawa
mesh_terms: D000428:Alcohol Drinking / Q000009:adverse effects*; D000444:Aldehyde Dehydrogenase / Q000235:genetics*; D000071396:Aldehyde Dehydrogenase, Mitochondrial; D000483:Alleles; D044466:Asian People / Q000235:genetics; D004247:DNA / Q000235:genetics; D005260:Female; D005838:Genotype; D006801:Humans; D006973:Hypertension / Q000201:enzymology / Q000209:etiology*; D008297:Male; D008875:Middle Aged; D008928:Mitochondria / Q000201:enzymology*; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic / Q000235:genetics*; D012307:Risk Factors; D013482:Superoxide Dismutase / Q000235:genetics*; D000099156:Superoxide Dismutase 2
chemical_list: D000444:Aldehyde Dehydrogenase; D000071396:Aldehyde Dehydrogenase, Mitochondrial; D004247:DNA; D013482:Superoxide Dismutase; D000099156:Superoxide Dismutase 2; C096127:ALDH2 protein, human