title: Acute effects of pomegranate extract on postprandial lipaemia, vascular function and blood pressure.
abstract: We investigated whether a test drink enriched in pomegranate polyphenols, consumed with a high-fat meal, can reduce postprandial lipaemia and improve vascular function and blood pressure compared to placebo. Nineteen young, healthy men completed a randomized, controlled crossover trial. The active drink (containing a pomegranate extract) was consumed during a high-fat meal (ET-DUR) or 15 min before (ET-PRE), and the placebo drink (no pomegranate extract) was consumed during the high-fat meal (CONTROL). Postprandial lipaemia was assessed by venous plasma TAG 0-2 h, and capillary plasma TAG 0-4 h. Blood pressure and digital volume pulse, to measure reflection index (DVP-RI) and stiffness index (DVP-SI), were monitored at baseline, 2 and 4 h. There was no inhibition of postprandial lipaemia by the active drink compared to CONTROL. ET-PRE caused a greater increase in the venous plasma TAG at 2 h compared to CONTROL and ET-DUR (treatment effect P = 0.001). The incremental area under the curve 0-4 h for capillary plasma TAG was not significantly different between treatments. Systolic blood pressure (SBP) increased in the ET-PRE and ET-DUR groups to a lesser extent than the CONTROL group (treatment effect P = 0.041). There were no treatment effects for DVP-RI, DVP-SI or diastolic blood pressure. In conclusion, the consumption of a single drink containing ET-rich pomegranate extract did not decrease postprandial plasma TAG concentrations, but suppressed the postprandial increase in SBP following the high-fat meal.
authors.affiliation: Diabetes & Nutritional Sciences Division, School of Medicine, King's College London, London, UK.
authors.forename: Aarati Susan
authors.initials: AS
authors.lastname: Mathew
authors.forename: Gabriella M
authors.initials: GM
authors.lastname: Capel-Williams
authors.forename: Sarah E E
authors.initials: SE
authors.lastname: Berry
authors.forename: Wendy L
authors.initials: WL
authors.lastname: Hall
mesh_terms: D000293:Adolescent; D000328:Adult; D001786:Blood Glucose / Q000187:drug effects; D001794:Blood Pressure / Q000187:drug effects*; D002320:Cardiovascular Physiological Phenomena / Q000187:drug effects; D002784:Cholesterol / Q000097:blood; D018592:Cross-Over Studies; D059305:Diet, High-Fat / Q000009:adverse effects; D006801:Humans; D047348:Hydrolyzable Tannins / Q000494:pharmacology*; D006949:Hyperlipidemias / Q000188:drug therapy*; D029561:Lythraceae / Q000737:chemistry*; D008297:Male; D010936:Plant Extracts / Q000494:pharmacology / Q000627:therapeutic use; D059808:Polyphenols / Q000494:pharmacology*; D019518:Postprandial Period / Q000502:physiology; D011674:Pulse; D016037:Single-Blind Method; D014280:Triglycerides / Q000097:blood; D055815:Young Adult
chemical_list: D001786:Blood Glucose; D047348:Hydrolyzable Tannins; D010936:Plant Extracts; D059808:Polyphenols; D014280:Triglycerides; C013515:ellagitannin; D002784:Cholesterol