title: Adjuvant radiotherapy in the management of axillary node negative invasive breast cancer: a qualitative systematic review.
abstract: OBJECTIVE
  To actualize and to detail guidelines used in technical radiotherapy and indications for innovative radiation technologies in early axillary node negative breast cancer (BC).
  
  
  METHODS
  Dosimetric and treatment planning studies, phase II and III trials, systematic reviews and retrospective studies were all searched (Medline(®) database). Their quality and clinical relevance were also checked against validated checklists. A level of evidence was associated for each result.
  
  
  RESULTS
  A total of 75 references were included. Adjuvant BC radiotherapy (50Gy/25 fractions/5 weeks followed by a tumor boost of 16Gy/8 fractions) is still the standard of care. Overall treatment time could be shortened for patients who present with low local relapse risk BC by using either hypofractionated whole breast irradiation; or accelerated partial breast irradiation. BC IMRT is not used in current practice.
  
  
  CONCLUSIONS
  Our group aimed to provide guidelines for technical and clinical applications of innovative BC radiation technologies.
authors.affiliation: Radiation Oncology Department, Institut Gustave Roussy, Villejuif, France. bourgier@igr.fr
authors.forename: C
authors.initials: C
authors.lastname: Bourgier
authors.forename: L
authors.initials: L
authors.lastname: Aimard
authors.forename: V
authors.initials: V
authors.lastname: Bodez
authors.forename: M A
authors.initials: MA
authors.lastname: Bollet
authors.forename: B
authors.initials: B
authors.lastname: Cutuli
authors.forename: D
authors.initials: D
authors.lastname: Franck
authors.forename: C
authors.initials: C
authors.lastname: Hennequin
authors.forename: Y M
authors.initials: YM
authors.lastname: Kirova
authors.forename: D
authors.initials: D
authors.lastname: Azria
mesh_terms: D001365:Axilla; D001943:Breast Neoplasms / Q000473:pathology / Q000532:radiotherapy* / Q000601:surgery; D005260:Female; D006801:Humans; D008198:Lymph Nodes / Q000473:pathology*; D008207:Lymphatic Metastasis; D015412:Mastectomy, Segmental; D009361:Neoplasm Invasiveness; D011880:Radiotherapy Planning, Computer-Assisted; D018714:Radiotherapy, Adjuvant; D047368:Tumor Burden