title: Susceptibility to toxoplasmic retinochoroiditis is associated with HLA alleles reported to be implicated with rapid progression to AIDS.
abstract: OBJECTIVE
  The frequency of HLA markers associated with rapid progression to AIDS was evaluated in Brazilian patients with AIDS exhibiting or not toxoplasmic retinochoroiditis (TRC).
  
  
  METHODS
  98 AIDS patients (25 with TRC, 43 with anti-T. gondii antibodies but without TCR, and 30 without anti-T. gondii antibodies and without TCR) were studied.
  
  
  RESULTS
  The HLA-B35 was significantly increased in TRC group (p=0.0038).
  
  
  CONCLUSIONS
  The presence of HLA-B35 may simultaneously predispose to progression to AIDS and TRC.
authors.affiliation: Department of Ophthalmology, Otorhinolaringology and Head and Neck Surgery, School of Medicine of Ribeirão Preto, University of São Paulo, Brazil.
authors.forename: Ana Lúcia G
authors.initials: AL
authors.lastname: Demarco
authors.forename: Maria de Lourdes V
authors.initials: Mde L
authors.lastname: Rodrigues
authors.forename: José Fernando C
authors.initials: JF
authors.lastname: Figueiredo
authors.forename: Neifi Hassam S
authors.initials: NH
authors.lastname: Deghaide
authors.forename: Marcelo Bezerra
authors.initials: MB
authors.lastname: de Menezes
authors.forename: Luís A
authors.initials: LA
authors.lastname: Demarco
authors.forename: Ana Paula M
authors.initials: AP
authors.lastname: Fernandes
authors.forename: Eduardo A
authors.initials: EA
authors.lastname: Donadi
mesh_terms: D000163:Acquired Immunodeficiency Syndrome / Q000097:blood* / Q000150:complications / Q000235:genetics; D000328:Adult; D000483:Alleles; D015415:Biomarkers / Q000097:blood; D016022:Case-Control Studies; D002825:Chorioretinitis / Q000097:blood* / Q000150:complications / Q000235:genetics; D018450:Disease Progression; D005260:Female; D020022:Genetic Predisposition to Disease; D015797:HLA-B35 Antigen / Q000097:blood*; D006801:Humans; D008297:Male; D008875:Middle Aged; D014126:Toxoplasmosis, Ocular / Q000097:blood* / Q000150:complications / Q000235:genetics
chemical_list: D015415:Biomarkers; D015797:HLA-B35 Antigen