title: [Interleukin-6 in endemic goiter patients in the south Ural region].
abstract: The cytokine and thyroid status was studied in patients with endemic goiter (EG) depending on thyroid function. IL-6 correlated with free T3 levels (a negative relationship) in hyperthyroidism, with IL-2 and IFN-gamma levels in EG patients with euthyroidism, and with IL-1beta, IL-2, IL-8, IL-10, and IFN-gamma in hypothyroidism. The EG patients with high IL-6 levels showed positive relationships to IL-2 and thyroid peroxidase antibodies and a negative relationship to free T3. In these patients, IL-6 acted to stimulate the secretion of antithyroid antibodies, which is a risk of autoimmune thyroiditis.
authors.forename: E V
authors.initials: EV
authors.lastname: Popova
authors.forename: N P
authors.initials: NP
authors.lastname: Popova
authors.forename: I V
authors.initials: IV
authors.lastname: Aliab'eva
authors.forename: E R
authors.initials: ER
authors.lastname: Gatiatulina
mesh_terms: D001323:Autoantibodies / Q000097:blood / Q000276:immunology; D015415:Biomarkers / Q000097:blood; D006043:Goiter, Endemic / Q000097:blood* / Q000453:epidemiology / Q000276:immunology; D006801:Humans; D015850:Interleukin-6 / Q000097:blood*; D015995:Prevalence; D012426:Russia / Q000453:epidemiology
chemical_list: D001323:Autoantibodies; D015415:Biomarkers; D015850:Interleukin-6; C056626:thyroid microsomal antibodies