title: Antihyperglycemic effects of fermented and nonfermented mung bean extracts on alloxan-induced-diabetic mice.
abstract: Mung bean was reported as a potential antidiabetic agent while fermented food has been proposed as one of the major contributors that can reduce the risk of diabetes in Asian populations. In this study, we have compared the normoglycemic effect, glucose-induced hyperglycemic effect, and alloxan-induced hyperglycemic effect of fermented and nonfermented mung bean extracts. Our results showed that fermented mung bean extracts did not induce hypoglycemic effect on normal mice but significantly reduced the blood sugar levels of glucose- and alloxan-induced hyperglycemic mice. The serum levels of cholesterol, triglyceride (TG), and low-density lipoprotein (LDL) were also lowered while insulin secretion and antioxidant level as measured by malonaldehyde (MDA) assays were significantly improved in the plasma of the fermented mung bean-treated group in alloxan-induced hyperglycemic mouse. These results indicated that fermentation using Mardi Rhizopus sp. strain 5351 inoculums could enhance the antihyperglycemic and the antioxidant effects of mung bean in alloxan-treated mice. The improvement in the antihyperglycemic effect may also be contributed by the increased content of GABA and the free amino acid that are present in the fermented mung bean extracts.
authors.affiliation: Institute of Bioscience, Universiti Putra Malaysia, Selangor, 43400 Serdang, Malaysia.
authors.forename: Swee Keong
authors.initials: SK
authors.lastname: Yeap
authors.forename: Norlaily
authors.initials: N
authors.lastname: Mohd Ali
authors.forename: Hamidah
authors.initials: H
authors.lastname: Mohd Yusof
authors.forename: Noorjahan Banu
authors.initials: NB
authors.lastname: Alitheen
authors.forename: Boon Kee
authors.initials: BK
authors.lastname: Beh
authors.forename: Wan Yong
authors.initials: WY
authors.lastname: Ho
authors.forename: Soo Peng
authors.initials: SP
authors.lastname: Koh
authors.forename: Kamariah
authors.initials: K
authors.lastname: Long
mesh_terms: D000496:Alloxan; D000818:Animals; D001786:Blood Glucose / Q000032:analysis; D003921:Diabetes Mellitus, Experimental / Q000139:chemically induced / Q000188:drug therapy*; D007887:Fabaceae / Q000737:chemistry* / Q000382:microbiology*; D005285:Fermentation; D007004:Hypoglycemic Agents / Q000627:therapeutic use; D051379:Mice; D008807:Mice, Inbred BALB C; D010936:Plant Extracts / Q000627:therapeutic use*; D016896:Treatment Outcome
chemical_list: D001786:Blood Glucose; D007004:Hypoglycemic Agents; D010936:Plant Extracts; D000496:Alloxan