title: Transsphenoidal surgery for a life-threatening prolactinoma apoplexy during pregnancy.
abstract: Prolactinoma is the most common secreting pituitary adenoma. It is typically diagnosed in women of reproductive age and is common cause of infertility. Currently the treatment of choice is pharmacotherapy with dopamine agonists, whereas surgical treatment is reserved for a selected group of patients. Pituitary-tumor apoplexy is a rare, life-threatening condition associated with significant morbidity and mortality.  The authors present the case of a 25-year-old woman with prolactinoma treated with dopamine agonist. In course of such a treatment the patient became pregnant. The bromocriptine was gradually withdrawn. In the 14th week of pregnancy she was admitted for symptoms suggesting pituitary tumor apoplexy. The treatment with bromocriptine was reinitiated. In the 20th week of pregnancy further deterioration of the patient's neurological condition and visual-field abnormalities were observed. The patient was qualified for surgical treatment - selective transsphenoidal adenomectomy. The successful surgery led to improvement of neurological condition. The early postoperative PRL level decreased significantly and hormonal function of the pituitary was preserved. The pregnancy ended in 38th week with a caesarean section. Endocrinological evaluation conducted after the uneventful delivery confirmed normal function of the pituitary. Magnetic resonance imaging (MRI) did not reveal tumor re-growth. The patient is kept under constant medical care. In this case study the authors discussed therapeutic management and reviewed literature regarding gestational pituitary-tumor apoplexy with particular emphasis on surgical treatment.
authors.affiliation: Department of Endocrinology and Isotope Therapy, Military Institute of Medicine, Warsaw, Poland. pwitek@wim.mil.pl
authors.forename: Przemysław
authors.initials: P
authors.lastname: Witek
authors.forename: Grzegorz
authors.initials: G
authors.lastname: Zieliński
authors.forename: Maria
authors.initials: M
authors.lastname: Maksymowicz
authors.forename: Wojciech
authors.initials: W
authors.lastname: Zgliczyński
mesh_terms: D000328:Adult; D016638:Critical Illness; D018491:Dopamine Agonists / Q000627:therapeutic use; D005260:Female; D006801:Humans; D019635:Neurosurgical Procedures / Q000379:methods*; D010899:Pituitary Apoplexy / Q000188:drug therapy / Q000473:pathology / Q000601:surgery*; D010911:Pituitary Neoplasms / Q000188:drug therapy / Q000473:pathology / Q000601:surgery*; D011247:Pregnancy; D011248:Pregnancy Complications / Q000188:drug therapy / Q000473:pathology / Q000601:surgery*; D015175:Prolactinoma / Q000188:drug therapy / Q000473:pathology / Q000601:surgery*; D013100:Sphenoid Bone / Q000601:surgery
chemical_list: D018491:Dopamine Agonists