title: Chromatin roadblocks to reprogramming 50 years on.
abstract: A half century after John Gurdon demonstrated nuclear reprogramming, for which he was awarded the 2012 Nobel Prize in Physiology or Medicine, his group provides insights into the molecular mechanisms whereby chromatin remodeling is required for nuclear reprogramming. Among the issues addressed in Gurdon's latest work are the chromatin impediments to artificially induced reprogramming, discovered by Shinya Yamanaka, who shared the award with Gurdon.
authors.affiliation: Howard Hughes Medical Institute, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA. steveh@fhcrc.org
authors.forename: Peter J
authors.initials: PJ
authors.lastname: Skene
authors.forename: Steven
authors.initials: S
authors.lastname: Henikoff
mesh_terms: D002467:Cell Nucleus / Q000502:physiology*; D065150:Cellular Reprogramming / Q000502:physiology*; D002843:Chromatin / Q000502:physiology*; D042002:Chromatin Assembly and Disassembly / Q000502:physiology*; D005786:Gene Expression Regulation; D006657:Histones; D057026:Induced Pluripotent Stem Cells / Q000502:physiology*
chemical_list: D002843:Chromatin; D006657:Histones