title: Evaluation of the possible epileptogenic activity of ciprofloxacin: the role of Nigella sativa on amino acids neurotransmitters.
abstract: The neuroprotective effect of Nigella sativa (NS) on amino acid neurotransmitters alteration in pentylenetetrazole (PTZ) and ciprofloxacin (CFX) treated rats in different brain regions was examined. The oral administration of NS induced an elevation in aspartate and glutamate contents, whereas the levels of GABA and glycine were decreased. Furthermore, the treated groups with PTZ and CFX caused a decrease in aspartate, glutamate and total antioxidant capacity levels, while the concentrations of GABA and glycine were increased after 14 days. Moreover, the pre- and post-treatment with NS in PTZ and CFX treated rats return the levels of these parameters near control values. So, it could be concluded that the treatment with CFX induced imbalance between the excitatory and the inhibitory amino acids which may lead to the initiation of epileptic seizures and the treatment with NS was found to ameliorate these neurological defects which reflect its potent antiepileptic activity.
authors.affiliation: Biology Department, Jazan University, Jazan, Saudi Arabia. nadianeuro@yahoo.com
authors.forename: Nadia M S
authors.initials: NM
authors.lastname: Arafa
authors.forename: Mona
authors.initials: M
authors.lastname: Abdel-Rahman
authors.forename: Manal F
authors.initials: MF
authors.lastname: El-khadragy
authors.forename: Rami B
authors.initials: RB
authors.lastname: Kassab
mesh_terms: D000596:Amino Acids / Q000378:metabolism*; D000818:Animals; D000900:Anti-Bacterial Agents / Q000633:toxicity*; D000927:Anticonvulsants / Q000494:pharmacology*; D000975:Antioxidants / Q000378:metabolism; D001923:Brain Chemistry / Q000187:drug effects; D002851:Chromatography, High Pressure Liquid; D002939:Ciprofloxacin / Q000633:toxicity*; D003292:Convulsants; D004827:Epilepsy / Q000139:chemically induced / Q000188:drug therapy* / Q000378:metabolism; D008297:Male; D018377:Neurotransmitter Agents / Q000378:metabolism*; D031881:Nigella sativa / Q000737:chemistry*; D010433:Pentylenetetrazole; D010936:Plant Extracts / Q000494:pharmacology; D051381:Rats; D014635:Valproic Acid / Q000627:therapeutic use
chemical_list: D000596:Amino Acids; D000900:Anti-Bacterial Agents; D000927:Anticonvulsants; D000975:Antioxidants; D003292:Convulsants; D018377:Neurotransmitter Agents; D010936:Plant Extracts; D002939:Ciprofloxacin; D014635:Valproic Acid; D010433:Pentylenetetrazole