title: Effect of dietary zinc deficiency on ischemic vulnerability of the brain.
abstract: Deficiency of zinc, which modulates glutamate release, might increase ischemic vulnerability of the brain. We examined effects of dietary zinc deficiency for 2 weeks on ischemic vulnerability in several brain regions using dynamic positron autoradiography technique and [18F]2-fluoro-2-deoxy-d-glucose with rat brain slices. In the normal diet group, the cerebral glucose metabolic rate (CMRglc) was not significantly different from that of the ischemia-unloaded control even after the loading of ischemia for 45 min. However, in the zinc-deficient diet group, CMRglc was significantly lower than that of the ischemia-unloaded control after loading of ischemia for 45 min. With treatment of MK-801 (NMDA receptor antagonist) from the start of ischemia loading, CMRglc was not significantly different from that of the ischemia-unloaded control. These findings, obtained for all analyzed brain regions, suggest that dietary zinc deficiency increased ischemic vulnerability in the brain, and that glutamate might contribute to this effect through activation of the NMDA receptor.
authors.affiliation: Department of Neuropsychiatry, Faculty of Medical Sciences, University of Fukui, 23-3 Matsuokashimoaizuki, Eiheiji-cho, Yoshida-gun, Fukui 910-1193, Japan. omata@u-fukui.ac.jp
authors.forename: Naoto
authors.initials: N
authors.lastname: Omata
authors.forename: Tetsuhito
authors.initials: T
authors.lastname: Murata
authors.forename: Nobuyuki
authors.initials: N
authors.lastname: Maruoka
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Ikeda
authors.forename: Hironori
authors.initials: H
authors.lastname: Mitsuya
authors.forename: Tomoyuki
authors.initials: T
authors.lastname: Mizuno
authors.forename: Kayo
authors.initials: K
authors.lastname: Mita
authors.forename: Mizuki
authors.initials: M
authors.lastname: Asano
authors.forename: Yasushi
authors.initials: Y
authors.lastname: Kiyono
authors.forename: Hidehiko
authors.initials: H
authors.lastname: Okazawa
authors.forename: Yuji
authors.initials: Y
authors.lastname: Wada
mesh_terms: D000818:Animals; D001345:Autoradiography / Q000379:methods; D002545:Brain Ischemia / Q000097:blood / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000209:etiology / Q000378:metabolism*; D002540:Cerebral Cortex / Q000187:drug effects / Q000378:metabolism*; D004032:Diet; D004195:Disease Models, Animal; D016291:Dizocilpine Maleate / Q000494:pharmacology / Q000627:therapeutic use; D018691:Excitatory Amino Acid Antagonists / Q000494:pharmacology / Q000627:therapeutic use; D019788:Fluorodeoxyglucose F18; D005947:Glucose / Q000378:metabolism*; D011877:Radionuclide Imaging; D051381:Rats; D017208:Rats, Wistar; D015032:Zinc / Q000172:deficiency* / Q000378:metabolism
chemical_list: D018691:Excitatory Amino Acid Antagonists; D019788:Fluorodeoxyglucose F18; D016291:Dizocilpine Maleate; D005947:Glucose; D015032:Zinc