title: Botulinum toxin in neurogenic detrusor overactivity.
abstract: OBJECTIVE
  To evaluate the effects of botulinum toxin on urodynamic parameters and quality of life in patients with neurogenic detrusor overactivity.
  
  
  METHODS
  Thirty four adult patients with spinal cord injury and detrusor overactivity were selected. The patients received 300 units of botulinum toxin type A. The endpoints evaluated with the episodes of urinary incontinence and measured the maximum cystometric capacity, maximum amplitude of detrusor pressure and bladder compliance at the beginning and end of the study (24 weeks) and evaluated the quality of life by applying the Qualiveen questionnaire.
  
  
  RESULTS
  A significant decrease in the episodes of urinary incontinence was observed. All urodynamic parameters presented a significant improvement. The same was observed in the quality of life index and the specific impact of urinary problems scores from the Qualiveen questionnaire. Six patients did not complete the study, two due to incomplete follow-up, and four violated protocol and were excluded from the analyses. No systemic adverse events of botulinum toxin type A were reported.
  
  
  CONCLUSIONS
  A botulinum toxin type A showed a significantly improved response in urodynamics parameters and specific and general quality of life.
authors.affiliation: Division of Urology, University of Campinas School of Medicine, Campinas, Sao Paulo, Brazil.
authors.forename: Carlos Arturo Levi
authors.initials: CA
authors.lastname: D'Ancona
authors.forename: Rúiter Silva
authors.initials: RS
authors.lastname: Ferreira
authors.forename: Mauricio Carneiro
authors.initials: MC
authors.lastname: Rassi
keywords: Botulinum toxins; Overactive urinary bladder; Quality of life; Urodynamics