title: Sinoscrewtine, an alkaloid with novel skeleton from the roots of Sinomenium acutum.
abstract: An alkaloid with novel skeleton, sinoscrewtine (1), has been isolated from the roots of Sinomenium acutum. Its structure was established by spectral analysis and X-ray crystallographic study, and its possible biosynthetic pathway was delivered. In vitro experiments, 1 showed weak injurious effects against H(2)O(2)/Aβ(25-35) induced oxidative injury in PC-12 cells and DPPH radical scavenging activity with IC(50) of 32.6μM.
authors.affiliation: Key Laboratory of Phytochemistry of Shaanxi Province, Baoji University of Arts and Sciences, Baoji 721013, China. xlwangwang@163.com
authors.forename: Xiao-Ling
authors.initials: XL
authors.lastname: Wang
authors.forename: Bing-Rui
authors.initials: BR
authors.lastname: Liu
authors.forename: Chien-Kuang
authors.initials: CK
authors.lastname: Chen
authors.forename: Guo-Wei
authors.initials: GW
authors.lastname: Qin
authors.forename: Shoei-Sheng
authors.initials: SS
authors.lastname: Lee
mesh_terms: D000470:Alkaloids / Q000737:chemistry* / Q000494:pharmacology*; D000818:Animals; D008958:Models, Molecular; D015394:Molecular Structure; D018696:Neuroprotective Agents / Q000737:chemistry* / Q000494:pharmacology*; D016716:PC12 Cells; D018517:Plant Roots / Q000737:chemistry*; D051381:Rats; D032841:Sinomenium / Q000737:chemistry*
chemical_list: D000470:Alkaloids; D018696:Neuroprotective Agents; C582248:sinoscrewtine