title: External support in preventing vein graft failure.
abstract: Saphenous vein remains a widely used conduit in coronary surgery. However, the long-term success of surgical myocardial revascularization is largely limited by the development of neointimal hyperplasia and superimposed atherosclerosis in vein grafts. Although strategies for preventing vein graft failure have been constantly explored, few therapeutic interventions to date have shown sustained benefits in the clinical setting. The application of external support has emerged as a promising strategy for modulating the overall biomechanical responses in venous wall. Nonetheless, clinical translation of this intervention has been formerly challenged, primarily due to several technique limitations. The purpose of the current review is to summarize the possible mechanisms involved in the external support strategy for preventing vein graft failure. Furthermore, several previously tested biomaterials and delivery techniques are also highlighted.
authors.affiliation: Division of Cardiothoracic Surgery, Department of Surgery, The Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong, People's Republic of China.
authors.forename: Jia
authors.initials: J
authors.lastname: Hu
authors.forename: Song
authors.initials: S
authors.lastname: Wan
mesh_terms: D000818:Animals; D001696:Biomechanical Phenomena; D001026:Coronary Artery Bypass / Q000009:adverse effects*; D006083:Graft Occlusion, Vascular / Q000209:etiology / Q000473:pathology / Q000503:physiopathology / Q000517:prevention & control*; D006801:Humans; D006965:Hyperplasia; D058426:Neointima; D011474:Prosthesis Design; D012501:Saphenous Vein / Q000473:pathology / Q000503:physiopathology / Q000637:transplantation*; D015607:Stents; D017211:Treatment Failure; D014654:Vascular Patency