title: Lack of association between the CYP1A1 Ile462Val polymorphism and endometrial cancer risk: a meta-analysis.
abstract: OBJECTIVE
  Any association between the CYP1A1 Ile462Val polymorphism and endometrial cancer risk remains inconclusive. For a more precise estimate, we performed the present meta-analysis.
  
  
  METHODS
  PUBMED, OVID and EMBASE were searched for the studies which met inclusion criteria. Data in all eligible studies were evaluated and extracted by two authors independently. The meta-analysis estimated pooled odds ratio (OR) with 95% confidence interval (CI) for endometrial cancer risk attributable to the CYP1A1 Ile462Val polymorphism.
  
  
  RESULTS
  A total of 7 studies were included in this meta-analysis. The results indicated no association between endometrial cancer risk and the CYP1A1 Ile462Val polymorphism (for Val vs Ile allele model [OR 1.09, 95% CI 0.73-1.62]; for Val.Val vs Ile.Ile genotype model [OR 1.54, 95% CI 0.56-4.23]; for (Ile.Val + Val.Val) vs Ile.Ile genotype model [OR 1.08, 95% CI 0.71-1.63]; for Val.Val vs (Ile.Ile + Ile.Val) genotype model [OR 1.46, 95% CI 0.53-4.04]).
  
  
  CONCLUSIONS
  This meta-analysis suggests that there is no association between endometrial cancer risk and the CYP1A1 Ile462Val polymorphism.
authors.affiliation: Bao'an Maternal and Child Health Hospital, Shenzhen, China.
authors.forename: Xi-Wen
authors.initials: XW
authors.lastname: Wang
authors.forename: Tian-Yu
authors.initials: TY
authors.lastname: Zhong
authors.forename: Yun-Hui
authors.initials: YH
authors.lastname: Xiong
authors.forename: Hai-Bo
authors.initials: HB
authors.lastname: Lin
authors.forename: Qing-Yi
authors.initials: QY
authors.lastname: Liu
mesh_terms: D016022:Case-Control Studies; D019363:Cytochrome P-450 CYP1A1 / Q000235:genetics*; D016889:Endometrial Neoplasms / Q000209:etiology*; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D012307:Risk Factors
chemical_list: C569463:CYP1A1 protein, human; D019363:Cytochrome P-450 CYP1A1