title: QSARs, data and error in the modern age of drug discovery.
abstract: The legacy of the advances made in high-throughput screening (HTS) in the 1990's is a large source of public data from which models can be derived using QSAR methods. This paper will examine the integrity of these public data sources and the implications for model building.
authors.affiliation: Novartis Institutes for Bio-Medical Research, Novartis Pharma AG, Novartis Campus, Basel, Switzerland.
authors.forename: Christian
authors.initials: C
authors.lastname: Kramer
authors.forename: Richard
authors.initials: R
authors.lastname: Lewis
mesh_terms: D030562:Databases, Protein; D055808:Drug Discovery; D057166:High-Throughput Screening Assays; D008958:Models, Molecular; D021281:Quantitative Structure-Activity Relationship; D012107:Research Design