title: [Genomic approach to pathophysiology of rheumatoid arthritis].
abstract: Genetic studies identified multiple genes and polymorphisms that increase risk to develop rheumatoid arthritis. Genomic approach is characterized with its integrative style using mathematical and statistical models. Its main targets include (1)combinatorial effect of multiple genetic and environmental factors, (2)heterogeneity of pathological states and its individuality, and (3)their chronological heterogeneity. Genomic approach will clarify pathophysiology of various diseases along with the progresses in molecular biology and other researches on individual molecules.
authors.affiliation: Graduate School of Medicine, Kyoto University, Japan.
authors.forename: Ryo
authors.initials: R
authors.lastname: Yamada
mesh_terms: D000818:Animals; D001172:Arthritis, Rheumatoid / Q000235:genetics* / Q000276:immunology / Q000503:physiopathology*; D020022:Genetic Predisposition to Disease; D023281:Genomics; D006801:Humans; D011110:Polymorphism, Genetic; D012307:Risk Factors; D013997:Time Factors