title: Inefficient vaginal transmission of tenofovir-resistant HIV-1.
abstract: Transmission of drug-resistant HIV has been postulated to be a threat to current first-line antiretroviral therapy (ART) regimens and the efficacy of several antiretroviral-based preexposure prophylaxis (PrEP) strategies being tested. Here we evaluated the effect of the common tenofovir (TFV) resistance mutation K65R on vaginal HIV transmission. Our results demonstrate that despite no overt loss of overall replication competence in vivo, this mutation results in significantly reduced mucosal transmission. When transmitted, the mutant virus eventually reverted to the wild type in 2 of 3 animals examined.
authors.affiliation: Division of Infectious Diseases, Department of Internal Medicine, Center for AIDS Research, University of North Carolina, Chapel Hill, NC, USA.
authors.forename: Morgan
authors.initials: M
authors.lastname: Chateau
authors.forename: Michael D
authors.initials: MD
authors.lastname: Swanson
authors.forename: J Victor
authors.initials: JV
authors.lastname: Garcia
mesh_terms: D000225:Adenine / Q000031:analogs & derivatives* / Q000494:pharmacology; D000818:Animals; D019380:Anti-HIV Agents / Q000494:pharmacology*; D004195:Disease Models, Animal; D024882:Drug Resistance, Viral; D005260:Female; D005838:Genotype; D015658:HIV Infections / Q000635:transmission* / Q000821:virology*; D015497:HIV-1 / Q000145:classification / Q000187:drug effects* / Q000235:genetics; D006801:Humans; D051379:Mice; D009092:Mucous Membrane / Q000821:virology; D020125:Mutation, Missense; D063065:Organophosphonates / Q000494:pharmacology*; D013489:Suppression, Genetic; D000068698:Tenofovir; D014621:Vagina / Q000821:virology
chemical_list: D019380:Anti-HIV Agents; D063065:Organophosphonates; D000068698:Tenofovir; D000225:Adenine