title: Potentiation of hemostimulating effects of erythropoietin with pegylated hyaluronate-endo-β-N-acetylhexosaminidase.
abstract: Pegylated hyaluronate-endo-β-N-acetylhexosaminidase considerably potentiates the hemostimulating effects of erythropoietin due to intensification of proliferation and differentiation of erythroid precursors against the background of enhanced secretion of hemopoietins by nonadherent hemopoiesis-inducing environment cells and elevation of serum erythropoietin concentration. The use of the enzyme allows 10-fold reduction of the maximum effective erythropoietin dose.
authors.affiliation: Siberian Division of the Russian Academy of Medical Sciences, Institute of Pharmacology, Tomsk, Russia.
authors.forename: A M
authors.initials: AM
authors.lastname: Dygai
authors.forename: G N
authors.initials: GN
authors.lastname: Zyuz'kov
authors.forename: V V
authors.initials: VV
authors.lastname: Zhdanov
authors.forename: E V
authors.initials: EV
authors.lastname: Udut
authors.forename: R V
authors.initials: RV
authors.lastname: Gurto
authors.forename: L A
authors.initials: LA
authors.lastname: Miroshnichenko
authors.forename: E V
authors.initials: EV
authors.lastname: Simanina
authors.forename: T Iu
authors.initials: TIu
authors.lastname: Khrichkova
authors.forename: L A
authors.initials: LA
authors.lastname: Stavrova
authors.forename: A V
authors.initials: AV
authors.lastname: Chaikovsky
authors.forename: A V
authors.initials: AV
authors.lastname: Artamonov
authors.forename: A A
authors.initials: AA
authors.lastname: Bekarev
authors.forename: P G
authors.initials: PG
authors.lastname: Madonov
authors.forename: M Iu
authors.initials: MIu
authors.lastname: Minakova
authors.forename: T S
authors.initials: TS
authors.lastname: Markova
mesh_terms: D000740:Anemia / Q000188:drug therapy*; D000818:Animals; D016190:Carboplatin; D004305:Dose-Response Relationship, Drug; D004357:Drug Synergism; D004797:Enzyme-Linked Immunosorbent Assay; D004906:Erythrocyte Count; D004921:Erythropoietin / Q000097:blood / Q000378:metabolism* / Q000494:pharmacology*; D005260:Female; D006454:Hemoglobins / Q000378:metabolism; D008297:Male; D051379:Mice; D008808:Mice, Inbred CBA; D036103:Nanotechnology / Q000379:methods; D011092:Polyethylene Glycols / Q000378:metabolism*; D011994:Recombinant Proteins; D018709:Statistics, Nonparametric; D001619:beta-N-Acetylhexosaminidases / Q000378:metabolism*
chemical_list: D006454:Hemoglobins; D011994:Recombinant Proteins; C103998:epoetin beta; D004921:Erythropoietin; D011092:Polyethylene Glycols; D016190:Carboplatin; D001619:beta-N-Acetylhexosaminidases