title: Hypofractionated helical intensity-modulated radiotherapy of the prostate bed after prostatectomy with or without the pelvic lymph nodes - the PRIAMOS trial.
abstract: BACKGROUND
  While evidence on safety and efficacy of primary hypofractionated radiotherapy in prostate cancer is accumulating, data on postoperative hypofractionated treatment of the prostate bed and of the pelvic lymph nodes is still scarce. This phase II trial was initiated to investigate safety and feasibility of hypofractionated treatment of the prostate bed alone or with the pelvic lymph nodes.
  
  
  METHODS
  A total of 80 prostate cancer patients with the indication for adjuvant radiotherapy will be enrolled, where 40 patients with a low risk of lymph node involvement (arm 1) and another 40 patients with a high risk of lymph node involvement (arm 2) will each receive 54 Gy in 18 fractions to the prostate bed. Arm 2 will be given 45 Gy to the pelvic lymph nodes additionally. Helical Tomotherapy and daily image guidance will be used.
  
  
  CONCLUSIONS
  This trial was initiated to substantiate data on hypofractionated treatment of the prostate bed and generate first data on adjuvant hypofractionated radiotherapy of the pelvic lymph nodes.
  
  
  BACKGROUND
  ClinicalTrials.gov; NCT01620710.
authors.affiliation: Department of Radiation Oncology, University Hospital Heidelberg, Im Neuenheimer Feld 400, 69120, Heidelberg, Germany. sonja.krause@med.uni-heidelberg.de
authors.forename: Sonja
authors.initials: S
authors.lastname: Krause
authors.forename: Florian
authors.initials: F
authors.lastname: Sterzing
authors.forename: Dirk
authors.initials: D
authors.lastname: Neuhof
authors.forename: Lutz
authors.initials: L
authors.lastname: Edler
authors.forename: Juergen
authors.initials: J
authors.lastname: Debus
authors.forename: Klaus
authors.initials: K
authors.lastname: Herfarth
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D017322:Clinical Trials, Phase II as Topic / Q000379:methods; D006727:Hormone Antagonists / Q000627:therapeutic use; D006801:Humans; D008198:Lymph Nodes / Q000473:pathology*; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D011468:Prostatectomy; D011471:Prostatic Neoplasms / Q000473:pathology* / Q000532:radiotherapy / Q000601:surgery / Q000628:therapy*; D011881:Radiotherapy, Computer-Assisted; D050397:Radiotherapy, Intensity-Modulated; D016019:Survival Analysis
chemical_list: D006727:Hormone Antagonists