title: [Endogenous cannabinoid system in the brain: role in regulation of seizure activity].
abstract: In overview one can find up-today data on endogenous cannabinoids (EC), their role in brain functioning. Interest in EC in recent years has significantly increased. Despite the fact that existence of EC-system among mammals was identified in nineties of the twenties century, deciphering the mechanisms of its functioning both in healthy brain as well in various pathologies, is far from final stage. The main function of EC in brain is implementation of the retrograde synaptic function of communication and neuromodulation. In overview one can see data on localization and functions of cannabinoids receptors and its endogenous ligands in CMS, as well as on EC-system participation in epileptiform activity modulation. Special focus on the analysis of works, where the projection revealed the role of EC in experimental modeling of the temporal epilepsy with animals, as well as for diseases in humans epilepsy. Set out the estimated survival mechanisms of cells and their repair provided by cannabinoid system in the generation of seizure activity; also provides information about the neurotoxic effects of EC. Possible reasons of contradictions are being discussed, that exist in the literature regarding the functions of EC in the brain.
authors.forename: L V
authors.initials: LV
authors.lastname: Shubina
authors.forename: V F
authors.initials: VF
authors.lastname: Kichigina
mesh_terms: D000818:Animals; D001921:Brain / Q000378:metabolism / Q000502:physiology; D063385:Cannabinoid Receptor Modulators / Q000378:metabolism / Q000502:physiology; D063388:Endocannabinoids / Q000378:metabolism* / Q000502:physiology; D006801:Humans; D009424:Nervous System Physiological Phenomena; D043884:Receptor, Cannabinoid, CB1 / Q000378:metabolism* / Q000502:physiology; D043885:Receptor, Cannabinoid, CB2 / Q000378:metabolism* / Q000502:physiology; D012640:Seizures / Q000378:metabolism / Q000503:physiopathology; D015398:Signal Transduction
chemical_list: D063385:Cannabinoid Receptor Modulators; D063388:Endocannabinoids; D043884:Receptor, Cannabinoid, CB1; D043885:Receptor, Cannabinoid, CB2