title: Prevalence and molecular identification of the mediterranean variant among G6PD-deficient Sistani and Balouch males in Southeastern Iran.
abstract: To determine the prevalence of G6PD deficiency and a Mediterranean mutation among males in southeastern Iran, we studied 1,097 Sistani and Balouch schoolboys. A questionnaire was used to collect demographic data and a history of malaria infection; blood samples were evaluated for G6PD deficiency and the G6PD Mediterranean mutation. Of the 1,097 boys screened, 175 were G6PD deficient (5.8 % of the Sistani boys and 19.3 % of the Balouch boys). The malaria survey indicated that among Balouch subjects, malaria infection was about 14 times that of Sistani subjects. Molecular characterization of G6PD-deficient samples revealed a general frequency of 85.1 % for the Mediterranean variant among all subjects (75 % among Sistani and 86.2 % among Balouch cases). The high prevalence of G6PD deficiency among Balouch populations confirms the hypothesis that the distribution of G6PD deficiency is concordant with the geographic distribution of malaria.
authors.affiliation: Genetics of Non-communicable Disease Research Center, Zahedan University of Medical Sciences, Zahedan, Iran. moghaddam4@yahoo.com
authors.forename: Ebrahim
authors.initials: E
authors.lastname: Miri-Moghaddam
authors.forename: Yousef
authors.initials: Y
authors.lastname: Mortazavi
authors.forename: Alireza
authors.initials: A
authors.lastname: Nakhaee
authors.forename: Abdurrashid
authors.initials: A
authors.lastname: Khazaei Feizabad
mesh_terms: D000293:Adolescent; D001483:Base Sequence; D002648:Child; D017931:DNA Primers; D005006:Ethnicity / Q000235:genetics*; D005955:Glucosephosphate Dehydrogenase Deficiency / Q000235:genetics*; D006801:Humans; D007492:Iran / Q000453:epidemiology; D008288:Malaria / Q000453:epidemiology / Q000235:genetics; D008297:Male
chemical_list: D017931:DNA Primers