title: The role of decitabine for the treatment of acute myeloid leukemia.
abstract: OBJECTIVE
  To review the available literature addressing the role of decitabine for the treatment of acute myeloid leukemia (AML).
  
  
  METHODS
  Relevant literature was identified by a PubMed search (January 1970-March 2012) of English-language literature using the terms decitabine, acute myeloid leukemia, and DNA methyltransferase inhibitors.
  
  
  METHODS
  All published studies and abstracts, as well as relevant consensus guidelines, evaluating the current literature about the role of decitabine for the treatment of AML were included.
  
  
  RESULTS
  Decitabine has been evaluated for the treatment of AML in several different settings. In patients with newly diagnosed AML who are not candidates for standard remission induction chemotherapy, a Phase 2 trial of decitabine administered for 5 days per cycle demonstrated a 24% complete remission rate (CR). A subsequent Phase 3 trial comparing decitabine and low-dose cytarabine or best supportive care in a similar patient population showed a greater CR rate (18% vs 8%; p = 0.001) but no overall survival benefit. A Phase 2 trial demonstrated a 47% CR rate with decitabine initially administered for 10 days per cycle, with subsequent doses customized to individual response and toxicity. This novel dosing schedule has yet to be evaluated in a Phase 3 trial. Decitabine is also being investigated for the treatment of relapsed/refractory AML and as bridge therapy to allogeneic hematopoietic stem cell transplantation.
  
  
  CONCLUSIONS
  Decitabine offers a promising alternative therapeutic option for patients with AML who are not candidates for standard remission induction chemotherapy. Because of its acceptable safety profile, research is investigating the clinical benefit of decitabine in combination with other antileukemic therapies. The potential roles of decitabine in the treatment of AML continue to be explored in numerous clinical trials.
authors.affiliation: Pharmacy Department, Hospital of the University of Pennsylvania, Philadelphia, PA, USA. alex.ganetsky@uphs.upenn.edu
authors.forename: Alex
authors.initials: A
authors.lastname: Ganetsky
mesh_terms: D000970:Antineoplastic Agents / Q000494:pharmacology / Q000627:therapeutic use*; D001374:Azacitidine / Q000031:analogs & derivatives* / Q000494:pharmacology / Q000627:therapeutic use; D015254:DNA Modification Methylases / Q000037:antagonists & inhibitors*; D000077209:Decitabine; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000188:drug therapy*
chemical_list: D000970:Antineoplastic Agents; D000077209:Decitabine; D015254:DNA Modification Methylases; D001374:Azacitidine