title: Dose-dependent IFN-stimulating and immunomodulating properties of 6H-indolo[2,3-B] quinoxaline derivatives.
abstract: Two 6H-indoloquinoxaline derivatives were studied in different doses and schemes of application for their INFgamma-inducing potential and ability to effect functional activity of phagocytic cells. Tested compounds were shown to possess comparable or higher activity than reference drug Amixin in analogous doses. One indoloquinoxaline significantly elevated metabolic activity of macrophages and increased their potential for phagocytosis. Application of multiple treatments and higher doses allowed us to reveal differences between studied derivatives that were not obvious in previous in vivo experiment. Capacity of 6H-indoloquinoxalines to induce vast IFN amounts on in vivo level was demonstrated for the first time.
authors.affiliation: Zabolotny Institute of Microbiology and Virology, National Academy of Sciences of Ukraine, 154 Acad Zabolotny St., Kyiv MSP 03680, Ukraine.
authors.forename: G V
authors.initials: GV
authors.lastname: Antonovych
authors.forename: N M
authors.initials: NM
authors.lastname: Zholobak
authors.forename: S A
authors.initials: SA
authors.lastname: Lyakhov
authors.forename: M O
authors.initials: MO
authors.lastname: Shibinska
authors.forename: S A
authors.initials: SA
authors.lastname: Andronati
authors.forename: M Y
authors.initials: MY
authors.lastname: Spivak
mesh_terms: D000818:Animals; D004306:Dose-Response Relationship, Immunologic; D005122:Exudates and Transudates / Q000737:chemistry / Q000276:immunology; D056747:Immunomodulation / Q000187:drug effects; D007211:Indoles / Q000138:chemical synthesis / Q000494:pharmacology*; D007274:Injections, Intraperitoneal; D007369:Interferon Inducers / Q000138:chemical synthesis / Q000494:pharmacology*; D007371:Interferon-gamma / Q000096:biosynthesis / Q000276:immunology*; D051379:Mice; D008807:Mice, Inbred BALB C; D008863:Microspheres; D010537:Peritoneum / Q000737:chemistry / Q000276:immunology; D010586:Phagocytes / Q000166:cytology / Q000187:drug effects* / Q000276:immunology; D010587:Phagocytosis / Q000187:drug effects / Q000276:immunology; D011810:Quinoxalines / Q000138:chemical synthesis / Q000494:pharmacology*; D013154:Spleen / Q000166:cytology / Q000187:drug effects / Q000276:immunology; D013994:Tilorone / Q000494:pharmacology
chemical_list: D007211:Indoles; D007369:Interferon Inducers; D011810:Quinoxalines; D007371:Interferon-gamma; D013994:Tilorone