title: IFN-inducible GTPases in host cell defense.
abstract: From plants to humans, the ability to control infection at the level of an individual cell-a process termed cell-autonomous immunity-equates firmly with survival of the species. Recent work has begun to unravel this programmed cell-intrinsic response and the central roles played by IFN-inducible GTPases in defending the mammalian cell's interior against a diverse group of invading pathogens. These immune GTPases regulate vesicular traffic and protein complex assembly to stimulate oxidative, autophagic, membranolytic, and inflammasome-related antimicrobial activities within the cytosol, as well as on pathogen-containing vacuoles. Moreover, human genome-wide association studies and disease-related transcriptional profiling have linked mutations in the Immunity-Related GTPase M (IRGM) locus and altered expression of guanylate binding proteins (GBPs) with tuberculosis susceptibility and Crohn's colitis.
authors.affiliation: Department of Microbial Pathogenesis, Boyer Centre for Molecular Medicine, Yale University School of Medicine, New Haven, CT 06510, USA.
authors.forename: Bae-Hoon
authors.initials: BH
authors.lastname: Kim
authors.forename: Avinash R
authors.initials: AR
authors.lastname: Shenoy
authors.forename: Pradeep
authors.initials: P
authors.lastname: Kumar
authors.forename: Clinton J
authors.initials: CJ
authors.lastname: Bradfield
authors.forename: John D
authors.initials: JD
authors.lastname: MacMicking
mesh_terms: D000818:Animals; D003424:Crohn Disease / Q000276:immunology; D022162:Cytoplasmic Vesicles / Q000378:metabolism; D020558:GTP Phosphohydrolases / Q000276:immunology* / Q000378:metabolism; D006801:Humans; D007372:Interferons / Q000276:immunology* / Q000378:metabolism; D014376:Tuberculosis / Q000276:immunology
chemical_list: D007372:Interferons; D020558:GTP Phosphohydrolases