title: Dragon TIS Spotter: an Arabidopsis-derived predictor of translation initiation sites in plants.
abstract: CONCLUSIONS
  In higher eukaryotes, the identification of translation initiation sites (TISs) has been focused on finding these signals in cDNA or mRNA sequences. Using Arabidopsis thaliana (A.t.) information, we developed a prediction tool for signals within genomic sequences of plants that correspond to TISs. Our tool requires only genome sequence, not expressed sequences. Its sensitivity/specificity is for A.t. (90.75%/92.2%), for Vitis vinifera (66.8%/94.4%) and for Populus trichocarpa (81.6%/94.4%), which suggests that our tool can be used in annotation of different plant genomes. We provide a list of features used in our model. Further study of these features may improve our understanding of mechanisms of the translation initiation.
  
  
  METHODS
  Our tool is implemented as an artificial neural network. It is available as a web-based tool and, together with the source code, the list of features, and data used for model development, is accessible at http://cbrc.kaust.edu.sa/dts.
authors.affiliation: King Abdullah University of Science and Technology (KAUST), Computational Bioscience Research Center, Thuwal 23955-6900, Saudi Arabia.
authors.forename: Arturo
authors.initials: A
authors.lastname: Magana-Mora
authors.forename: Haitham
authors.initials: H
authors.lastname: Ashoor
authors.forename: Boris R
authors.initials: BR
authors.lastname: Jankovic
authors.forename: Allan
authors.initials: A
authors.lastname: Kamau
authors.forename: Karim
authors.initials: K
authors.lastname: Awara
authors.forename: Rajesh
authors.initials: R
authors.lastname: Chowdhary
authors.forename: John A C
authors.initials: JA
authors.lastname: Archer
authors.forename: Vladimir B
authors.initials: VB
authors.lastname: Bajic
mesh_terms: D017360:Arabidopsis / Q000235:genetics*; D018745:Genome, Plant; D023281:Genomics; D020407:Internet; D016571:Neural Networks, Computer; D059372:Nucleotide Motifs; D010442:Peptide Chain Initiation, Translational; D012680:Sensitivity and Specificity; D017422:Sequence Analysis, DNA; D012984:Software