title: CD200/CD200R paired potent inhibitory molecules regulating immune and inflammatory responses; Part II: CD200/CD200R potential clinical applications.
abstract: CD200 and its receptor were recognized as having the multiple immunoregulatory functions. Their immunoregulatory, suppressive, and tolerogenic potentials could be very effectively exploited in the treatment of many diseases, e.g. Alzheimer disease, rheumatoid arthritis, and allergy to name only some. Many research projects are aimed to develop clinically valuable methods being based on the structure and function of these paired molecules. In this review, we would like to introduce CD200/CD200R functions in a clinical context.
authors.affiliation: Department of Clinical Immunology and Allergology, Charles University in Prague, Faculty of Medicine and University Hospital in Hradec Králove, Czech Republic.
authors.forename: Drahomíra
authors.initials: D
authors.lastname: Holmannová
authors.forename: Martina
authors.initials: M
authors.lastname: Kolácková
authors.forename: Katerina
authors.initials: K
authors.lastname: Kondelková
authors.forename: Pavel
authors.initials: P
authors.lastname: Kunes
authors.forename: Jan
authors.initials: J
authors.lastname: Krejsek
authors.forename: Andrjos
authors.initials: A
authors.lastname: Ctirad
mesh_terms: D000818:Animals; D015703:Antigens, CD / Q000276:immunology* / Q000627:therapeutic use; D001327:Autoimmune Diseases / Q000276:immunology; D002493:Central Nervous System Diseases / Q000276:immunology; D006801:Humans; D007109:Immunity; D009369:Neoplasms / Q000276:immunology / Q000628:therapy; D014181:Transplantation Immunology; D014777:Virus Diseases / Q000276:immunology
chemical_list: D015703:Antigens, CD; C042739:antigens, CD200