title: Indications, stains and techniques in chromoendoscopy.
abstract: Early detection of malignancies within the gastrointestinal tract is essential to improve the prognosis and outcome of affected patients. However, conventional white light endoscopy has a miss rate of up to 25% for gastrointestinal pathology, specifically in the context of small and flat lesions within the colon. Chromoendoscopy and other advanced imaging techniques aim at facilitating the visualization and detection of neoplastic lesions and have been applied throughout the gastrointestinal tract. Chromoendoscopy, particularly in combination with magnifying endoscopy has significantly improved means to detect neoplastic lesions in the gastrointestinal mucosa, particularly in ulcerative colitis and Crohn's colitis. In addition, chromoendoscopy is beneficial in the upper gastrointestinal tract, especially when evaluating Barrett's oesophagus (BO) for the presence of dysplasia. Furthermore, it also improves characterization, differentiation and diagnosis of endoscopically detected suspicious lesions, and helps to delineate the extent of neoplastic lesions that may be amenable to endoscopic resection. This review discusses the dyes, indications and advanced endoscopic imaging methods used in various chromoendoscopic techniques, and presents a critical overview of the existing evidence supporting their use in current practice with a particular emphasis on the role in inflammatory bowel disease and BO.
authors.affiliation: Centre for Liver Research and NIHR Institute of Biomedical Research, 5th Floor IBR Building, University of Birmingham, Birmingham B15 2TT, UK.
authors.forename: P J
authors.initials: PJ
authors.lastname: Trivedi
authors.forename: B
authors.initials: B
authors.lastname: Braden
mesh_terms: D001471:Barrett Esophagus / Q000175:diagnosis; D003093:Colitis, Ulcerative / Q000175:diagnosis; D004396:Coloring Agents; D003424:Crohn Disease / Q000175:diagnosis; D055088:Early Detection of Cancer / Q000379:methods; D016099:Endoscopy, Gastrointestinal / Q000379:methods; D004938:Esophageal Neoplasms / Q000175:diagnosis; D005260:Female; D005767:Gastrointestinal Diseases / Q000175:diagnosis* / Q000473:pathology; D005770:Gastrointestinal Neoplasms / Q000175:diagnosis; D006801:Humans; D015212:Inflammatory Bowel Diseases / Q000175:diagnosis; D008297:Male; D011230:Precancerous Conditions / Q000175:diagnosis; D011237:Predictive Value of Tests; D012680:Sensitivity and Specificity; D013194:Staining and Labeling; D041742:Upper Gastrointestinal Tract / Q000473:pathology*
chemical_list: D004396:Coloring Agents