title: Hypoglycemic, lipid lowering and antioxidant activities in root extract of Anthocephalus indicus in alloxan induced diabetic rats.
abstract: The present study was carried out to evaluate the hypoglycemic, lipid lowering and antioxidant activities in root extract of Anthocephalus indicus (A indicus) in alloxan inducd diabetic rats. Oral administration of ethanol extract of root (500mg/ kg body weight) for 21 days resulted in significant decrease in the levels of blood glucose, triglycerides, total cholesterol, phospholipid and free fatty acids. Furthermore, the root extract (100-400μg) inhibited the generation of superoxide anions and hydroxyl radicals, in both enzymic and non-enzymic systems, in vitro. The result of the present study demonstrated hypoglycemic, lipid lowering and antioxidant activities in root extract of A indicus, which could help in prevention of diabetic dyslipidemia and related diseases.
authors.affiliation: Department of Biochemistry, C S M Medical University, Lucknow, India.
authors.forename: Vishnu
authors.initials: V
authors.lastname: Kumar
authors.forename: A K
authors.initials: AK
authors.lastname: Khanna
authors.forename: M M
authors.initials: MM
authors.lastname: Khan
authors.forename: Ranjana
authors.initials: R
authors.lastname: Singh
authors.forename: Sushma
authors.initials: S
authors.lastname: Singh
authors.forename: Ramesh
authors.initials: R
authors.lastname: Chander
authors.forename: Farzana
authors.initials: F
authors.lastname: Mahdi
authors.forename: J K
authors.initials: JK
authors.lastname: Saxena
authors.forename: Shweta
authors.initials: S
authors.lastname: Saxena
authors.forename: V K
authors.initials: VK
authors.lastname: Singh
authors.forename: R K
authors.initials: RK
authors.lastname: Singh
keywords: Anthocephalus indicus; Hypoglycemic agent; Lipid lowering agent; Oxygen free radical scavengers; Plant antioxidant