title: Complications of acellular dermal matrices in abdominal wall reconstruction.
abstract: BACKGROUND
  Acellular dermal matrices have been increasingly used in abdominal wall reconstruction. Unique characteristics of these grafts have allowed surgeons to reconstruct increasingly complex abdominal wall defects. This has resulted in a myriad of complications related to the acellular dermal matrix with unique management strategies as compared with synthetic mesh.
  
  
  METHODS
  A review of the literature was performed to identify studies evaluating the use and efficacy of acellular dermal matrices in abdominal wall reconstruction. Complication profiles were identified and are compared. Differences between porcine and human derivatives were identified.
  
  
  RESULTS
  Hernia recurrence, infection, skin necrosis, and fluid collections were among the most common complications following abdominal wall reconstruction identified in the literature. Differences among various acellular dermal matrix products make certain types more suitable for abdominal wall reconstruction.
  
  
  CONCLUSIONS
  Complications are frequent in abdominal wall reconstruction. Many acellular dermal matrices have properties that allow for conservative management and maintenance of reconstruction when complications occur. With traditional synthetic mesh reconstruction, complications likely result in mesh explantation and prolonged morbidity. With acellular dermal matrix reconstruction, however, more conservative treatment strategies will allow for mesh salvage.
authors.affiliation: Washington, D.C. From the Departments of Plastic Surgery and Surgery, Georgetown University Hospital.
authors.forename: Ketan M
authors.initials: KM
authors.lastname: Patel
authors.forename: Parag
authors.initials: P
authors.lastname: Bhanot
mesh_terms: D000007:Abdominal Injuries / Q000601:surgery; D000008:Abdominal Neoplasms / Q000601:surgery; D034861:Abdominal Wall / Q000601:surgery*; D062088:Acellular Dermis / Q000009:adverse effects*; D002986:Clinical Trials as Topic; D003094:Collagen / Q000627:therapeutic use; D019317:Evidence-Based Medicine; D006406:Hematoma / Q000209:etiology / Q000601:surgery; D006555:Hernia, Ventral / Q000601:surgery; D059685:Herniorrhaphy / Q000379:methods; D006801:Humans; D006931:Hyperbaric Oxygenation; D009336:Necrosis; D011183:Postoperative Complications / Q000453:epidemiology / Q000209:etiology* / Q000517:prevention & control; D011446:Prospective Studies; D019651:Plastic Surgery Procedures / Q000379:methods*; D012008:Recurrence; D012189:Retrospective Studies; D049291:Seroma / Q000209:etiology / Q000601:surgery; D012867:Skin / Q000473:pathology; D013524:Surgical Flaps / Q000473:pathology; D013526:Surgical Mesh; D013529:Surgical Wound Dehiscence / Q000453:epidemiology / Q000517:prevention & control; D013530:Surgical Wound Infection / Q000453:epidemiology / Q000209:etiology / Q000517:prevention & control; D016896:Treatment Outcome; D014945:Wound Healing
chemical_list: C440568:Alloderm; D003094:Collagen