title: [Features of urapidil in treatment of resistant hypertension].
abstract: The review considers the possibility of using capsule form urapidila for combination therapy for treatment-resistant hypertension. The drug has a dual mechanism of action and combining the properties of -blockers and centrally acting drug, has a high efficiency, comparable to that of other groups of drugs, and good tolerability. In a review of the features of the mechanism of action, pharmacokinetics, and pharmacodynamics of the drug. The data of the major studies that demonstrate the effectiveness of antihypertensive urapidila. Additional features - favorable metabolic effects, the ability to improve the patency of the bronchi and lower the pressure in the pulmonary artery and its organoprotective, allow us to recommend this drug for the treatment of patients with concomitant diseases.
authors.forename: L O
authors.initials: LO
authors.lastname: Minushkina
mesh_terms: D058668:Adrenergic alpha-1 Receptor Antagonists / Q000627:therapeutic use; D001794:Blood Pressure / Q000187:drug effects*; D006801:Humans; D006973:Hypertension / Q000188:drug therapy* / Q000503:physiopathology; D010879:Piperazines / Q000627:therapeutic use*; D016896:Treatment Outcome
chemical_list: D058668:Adrenergic alpha-1 Receptor Antagonists; D010879:Piperazines; C015568:urapidil