title: Aggregate formation and radiolytic degradation of amphiphilic DNA block copolymer possessing disulfide bond.
abstract: We have designed a novel aggregate of DNA block copolymer (DBC) that is sensitive to hypoxic X-irradiation. The DBC consists of tetrahydropyrane-protected 2-hydroxyethyl methacrylate as a hydrophobic unit and oligodeoxynucleotides as a hydrophilic unit, which are linked to a radiation-sensitive disulfide bond. The DBC self-assembled efficiently to form aggregates that encapsulated small molecules such as nile red and pyrene. Hypoxic X-irradiation could then induce reductive degradation of the DBC aggregates via an exchange reaction of the disulfide bond to release guest molecules.
authors.affiliation: Department of Energy and Hydrocarbon Chemistry, Graduate School of Engineering, Kyoto University, Katsura Campus, Nishikyo-ku, Kyoto 615-8510, Japan. tanabeka@scl.kyoto-u.ac.jp
authors.forename: Kazuhito
authors.initials: K
authors.lastname: Tanabe
authors.forename: Takumi
authors.initials: T
authors.lastname: Asada
authors.forename: Sei-ichi
authors.initials: S
authors.lastname: Nishimoto
mesh_terms: D004247:DNA / Q000737:chemistry / Q000378:metabolism* / Q000528:radiation effects; D004220:Disulfides / Q000737:chemistry*; D004337:Drug Carriers / Q000737:chemistry; D057927:Hydrophobic and Hydrophilic Interactions; D008689:Methacrylates / Q000737:chemistry; D009838:Oligodeoxyribonucleotides / Q000737:chemistry; D010078:Oxazines / Q000737:chemistry; D011108:Polymers / Q000737:chemistry*; D011721:Pyrenes / Q000737:chemistry; D011839:Radiation, Ionizing
chemical_list: D004220:Disulfides; D004337:Drug Carriers; D008689:Methacrylates; D009838:Oligodeoxyribonucleotides; D010078:Oxazines; D011108:Polymers; D011721:Pyrenes; C005044:hydroxyethyl methacrylate; D004247:DNA; C030984:pyrene; C044808:nile red