title: Ultrasound-assisted extraction of carnosic acid and rosmarinic acid using ionic liquid solution from Rosmarinus officinalis.
abstract: Ionic liquid based, ultrasound-assisted extraction was successfully applied to the extraction of phenolcarboxylic acids, carnosic acid and rosmarinic acid, from Rosmarinus officinalis. Eight ionic liquids, with different cations and anions, were investigated in this work and [C(8)mim]Br was selected as the optimal solvent. Ultrasound extraction parameters, including soaking time, solid-liquid ratio, ultrasound power and time, and the number of extraction cycles, were discussed by single factor experiments and the main influence factors were optimized by response surface methodology. The proposed approach was demonstrated as having higher efficiency, shorter extraction time and as a new alternative for the extraction of carnosic acid and rosmarinic acid from R. officinalis compared with traditional reference extraction methods. Ionic liquids are considered to be green solvents, in the ultrasound-assisted extraction of key chemicals from medicinal plants, and show great potential.
authors.affiliation: State Engineering Laboratory for Bioresource Eco-Utilization, Northeast Forestry University, Harbin 150040, China.
authors.forename: Ge
authors.initials: G
authors.lastname: Zu
authors.affiliation: State Engineering Laboratory for Bioresource Eco-Utilization, Northeast Forestry University, Harbin 150040, China.
authors.forename: Rongrui
authors.initials: R
authors.lastname: Zhang
authors.affiliation: State Engineering Laboratory for Bioresource Eco-Utilization, Northeast Forestry University, Harbin 150040, China.
authors.forename: Lei
authors.initials: L
authors.lastname: Yang
authors.affiliation: State Engineering Laboratory for Bioresource Eco-Utilization, Northeast Forestry University, Harbin 150040, China.
authors.forename: Chunhui
authors.initials: C
authors.lastname: Ma
authors.affiliation: State Engineering Laboratory for Bioresource Eco-Utilization, Northeast Forestry University, Harbin 150040, China.
authors.forename: Yuangang
authors.initials: Y
authors.lastname: Zu
authors.affiliation: State Engineering Laboratory for Bioresource Eco-Utilization, Northeast Forestry University, Harbin 150040, China.
authors.forename: Wenjie
authors.initials: W
authors.lastname: Wang
authors.affiliation: State Engineering Laboratory for Bioresource Eco-Utilization, Northeast Forestry University, Harbin 150040, China.
authors.forename: Chunjian
authors.identifier: 0000-0003-2827-1999
authors.initials: C
authors.lastname: Zhao
mesh_terms: D045784:Abietanes / Q000378:metabolism*; D005591:Chemical Fractionation / Q000379:methods*; D002934:Cinnamates / Q000378:metabolism*; D053630:Depsides / Q000378:metabolism*; D052578:Ionic Liquids / Q000737:chemistry; D059625:Liquid-Liquid Extraction / Q000379:methods*; D010936:Plant Extracts / Q000737:chemistry / Q000378:metabolism*; D018515:Plant Leaves / Q000378:metabolism; D010946:Plants, Medicinal / Q000378:metabolism; D027542:Rosmarinus / Q000378:metabolism*; D012997:Solvents / Q000737:chemistry; D013016:Sound; D014463:Ultrasonography / Q000379:methods; D000097123:Rosmarinic Acid
chemical_list: D045784:Abietanes; D002934:Cinnamates; D053630:Depsides; D052578:Ionic Liquids; D010936:Plant Extracts; D012997:Solvents; D000097123:Rosmarinic Acid; C018381:salvin
keywords: Rosmarinus officinalis; carnosic acid; ionic liquid; response surface methodology; rosmarinic acid; ultrasound-assisted extraction