title: Mercury-thymine interaction with a chair type G-quadruplex architecture.
abstract: The T-Hg-T bond was utilized to cross-link two lateral loops of chair-type G-quadruplex DNA (G4-DNA) structures. Two out of five cross-linking geometries are able to increase the melting temperature and simultaneously reduce the polymorphism of the G4-DNA conformations.
authors.affiliation: Univ. Bordeaux, Inserm U, IECB, Pessac, France.
authors.forename: Nicole M
authors.initials: NM
authors.lastname: Smith
authors.forename: Samir
authors.initials: S
authors.lastname: Amrane
authors.forename: Frédéric
authors.initials: F
authors.lastname: Rosu
authors.forename: Valérie
authors.initials: V
authors.lastname: Gabelica
authors.forename: Jean-Louis
authors.initials: JL
authors.lastname: Mergny
mesh_terms: D001483:Base Sequence; D004247:DNA / Q000737:chemistry / Q000235:genetics; D054856:G-Quadruplexes / Q000187:drug effects; D008628:Mercury / Q000737:chemistry* / Q000494:pharmacology; D008958:Models, Molecular; D013941:Thymine / Q000737:chemistry*
chemical_list: D004247:DNA; D008628:Mercury; D013941:Thymine