title: An investigation of rheumatoid arthritis loci in patients with early-onset psoriasis validates association of the REL gene.
abstract: BACKGROUND
  Phenotypically diverse autoimmune conditions share common genetic susceptibility loci and underlying molecular pathways.
  
  
  OBJECTIVE
  By systematically searching for single nucleotide polymorphisms (SNPs) associated with another autoimmune disease, rheumatoid arthritis (RA), we aimed to elucidate novel genetic markers of psoriasis.
  
  
  METHODS
  We investigated 18 SNPs, previously confirmed as being associated with RA, in a U.K. cohort of 623 patients with early-onset psoriasis (presenting before age 40 years), comparing them with 2662 control subjects.
  
  
  RESULTS
  Our findings confirm the association of early-onset psoriasis with REL (rs13031237, P=0·0027). The minor allele of REL had opposing effects upon susceptibility to disease in patients with psoriasis and RA.
  
  
  CONCLUSIONS
  Similar exploration of additional autoimmune loci and fine mapping of such regions may provide further insight into the genetics and molecular pathophysiology of psoriasis.
authors.affiliation: The Dermatology Centre, Salford Royal NHS Foundation Trust, University of Manchester, Manchester M6 8HD, UK.
authors.forename: F R
authors.initials: FR
authors.lastname: Ali
authors.forename: A
authors.initials: A
authors.lastname: Barton
authors.forename: R L I
authors.initials: RL
authors.lastname: Smith
authors.forename: J
authors.initials: J
authors.lastname: Bowes
authors.forename: E
authors.initials: E
authors.lastname: Flynn
authors.forename: M
authors.initials: M
authors.lastname: Mangino
authors.forename: V
authors.initials: V
authors.lastname: Bataille
authors.forename: J P
authors.initials: JP
authors.lastname: Foerster
authors.forename: J
authors.initials: J
authors.lastname: Worthington
authors.forename: C E M
authors.initials: CE
authors.lastname: Griffiths
authors.forename: R B
authors.initials: RB
authors.lastname: Warren
mesh_terms: D000328:Adult; D001172:Arthritis, Rheumatoid / Q000235:genetics*; D020573:Genes, rel / Q000235:genetics*; D005819:Genetic Markers / Q000235:genetics; D020022:Genetic Predisposition to Disease / Q000235:genetics; D005838:Genotype; D006801:Humans; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D011565:Psoriasis / Q000235:genetics*; D012307:Risk Factors
chemical_list: D005819:Genetic Markers