title: Analysis of the cercosporin polyketide synthase CTB1 reveals a new fungal thioesterase function.
abstract: The polyketide synthase CTB1 is demonstrated to catalyze pyrone formation thereby expanding the known biosynthetic repertoire of thioesterase domains in iterative, non-reducing polyketide synthases.
authors.affiliation: Department of Chemistry, Johns Hopkins University, 3400 N. Charles St., Baltimore, MD 21218, USA.
authors.forename: Adam G
authors.initials: AG
authors.lastname: Newman
authors.forename: Anna L
authors.initials: AL
authors.lastname: Vagstad
authors.forename: Katherine
authors.initials: K
authors.lastname: Belecki
authors.forename: Jonathan R
authors.initials: JR
authors.lastname: Scheerer
authors.forename: Craig A
authors.initials: CA
authors.lastname: Townsend
mesh_terms: D001203:Ascomycota / Q000737:chemistry / Q000201:enzymology* / Q000378:metabolism; D010569:Perylene / Q000031:analogs & derivatives* / Q000737:chemistry / Q000378:metabolism; D048630:Polyketide Synthases / Q000737:chemistry / Q000378:metabolism*; D017434:Protein Structure, Tertiary; D011753:Pyrones / Q000737:chemistry / Q000378:metabolism*; D013869:Thiolester Hydrolases / Q000737:chemistry / Q000378:metabolism
chemical_list: D011753:Pyrones; D010569:Perylene; D048630:Polyketide Synthases; C026363:cercosporin; D013869:Thiolester Hydrolases