title: The dual role of inflammation in colon carcinogenesis.
abstract: Chronic inflammation characterizing patients with inflammatory bowel disease (IBD) represents a major risk factor for the development of colorectal cancer. Mechanisms underlying this neoplastic transformation are not fully understood though studies in experimental models of colon carcinogenesis suggest that inflammatory cell-derived cytokines either directly or indirectly stimulate the uncontrolled growth of cancer cells. Nevertheless, under specific inflammatory conditions, immune cells can boost an anti-tumor immune response with the down-stream effect of eliminating dysplastic and cancerous cells. This review outlines the beneficial and detrimental role of inflammation in colon carcinogenesis.
authors.affiliation: Department of Systems Medicine, University of Rome "Tor Vergata", Via Montpellier 1, Rome 00133, Italy.
authors.forename: Giovanni
authors.initials: G
authors.lastname: Monteleone
authors.affiliation: Department of Systems Medicine, University of Rome "Tor Vergata", Via Montpellier 1, Rome 00133, Italy.
authors.forename: Francesco
authors.initials: F
authors.lastname: Pallone
authors.affiliation: Department of Systems Medicine, University of Rome "Tor Vergata", Via Montpellier 1, Rome 00133, Italy.
authors.forename: Carmine
authors.identifier: 0000-0002-6354-2443
authors.initials: C
authors.lastname: Stolfi
mesh_terms: D015496:CD4-Positive T-Lymphocytes / Q000276:immunology; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology; D002471:Cell Transformation, Neoplastic / Q000276:immunology*; D003106:Colon / Q000473:pathology; D003110:Colonic Neoplasms / Q000276:immunology / Q000473:pathology*; D016207:Cytokines / Q000378:metabolism; D006801:Humans; D007249:Inflammation / Q000276:immunology / Q000473:pathology*; D015212:Inflammatory Bowel Diseases / Q000276:immunology / Q000473:pathology*; D012306:Risk
chemical_list: D016207:Cytokines
keywords: AOM + DSS; IBD; IL-17; IL-21; IL-6; T cells; colitis-associated colon cancer; inflammation; tumor immunosurveillance; ulcerative colitis