title: Effect of aqueous extract of Aegle marmelos unripe fruit on inflammatory bowel disease.
abstract: OBJECTIVE
  The present study was designed to evaluate the effect of Aegle marmelos unripe fruit extract (AMFE) on inflammatory bowel disease (IBD) in Wistar albino rats.
  
  
  METHODS
  Effect of AMFE was studied on acetic acid induced ulcerative colitis (1 ml of 4% acetic acid solution, transrectal) and indomethacin-induced enterocolitis (10 mg/kg, single dose, p.o) in Wistar albino rats. The extract was administered orally at different dose of 150, 200 and 250 mg/kg body weight. Disease pathogenesis was assessed by measuring disease activity index (DAI), macroscopic score, microscopic score, mesenteric mast cell protection, superoxide dismutase (SOD), and malonaldehyde (MDA) levels in the above two models.
  
  
  RESULTS
  The results showed a dose dependent decrease in intestinal inflammation following treatment with AMFE. Significant protection in mast cell degranulation was observed in acetic acid and indomethacin-induced IBD models. Treatment with AMFE significantly decreased the MDA levels and increased SOD activity.
  
  
  CONCLUSIONS
  In our study, AMFE produced anti-inflammatory, antioxidant, and mast cell stabilizing effects demonstrating protective effect in inflammatory bowel disease.
authors.affiliation: Department of Pharmacology, MKCG Medical College, Berhampur, Odisha, India.
authors.forename: Jayanti P
authors.initials: JP
authors.lastname: Behera
authors.forename: Bisweswar
authors.initials: B
authors.lastname: Mohanty
authors.forename: Y Roja
authors.initials: YR
authors.lastname: Ramani
authors.forename: Bandana
authors.initials: B
authors.lastname: Rath
authors.forename: Supriya
authors.initials: S
authors.lastname: Pradhan
mesh_terms: D045471:Aegle; D000818:Animals; D005260:Female; D005638:Fruit; D015212:Inflammatory Bowel Diseases / Q000188:drug therapy* / Q000473:pathology*; D008297:Male; D010936:Plant Extracts / Q000302:isolation & purification / Q000627:therapeutic use*; D051381:Rats; D017208:Rats, Wistar; D016896:Treatment Outcome; D014867:Water
chemical_list: D010936:Plant Extracts; D014867:Water
keywords: Aegle marmelos (bael); aqueous extract; inflammatory bowel disease