title: Granulomatous Mastitis during Chronic Antidepressant Therapy: Is It Possible a Conservative Therapeutic Approach?
abstract: Granulomatous mastitis is a rare benign inflammatory disease of the breast with multiple etiologies such as tuberculosis, sarcoidosis, foreign body reaction, and mycotic and parasitic infections. In contrast, idiopathic granulomatous mastitis (IGM) is characterized by the presence of chronic granulomatous lobulitis in the absence of an obvious etiology. Clinically and radiologically it may mimic breast carcinoma and so awareness of surgeons, pathologists, and radiologists is essential to avoid unnecessary mastectomies. Cases of IGM are reported during antidepressant therapy in patients also showing high levels of prolactinemia. In these cases, we believe that surgical excision must be avoided being replaced with a conservative management of the pathological condition based on a corticosteroid treatment.
authors.affiliation: University Hospital "P. Giaccone", University of Palermo School of Medicine, Palermo, Italy.
authors.forename: Maurizio
authors.initials: M
authors.lastname: Bellavia
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Damiano
authors.forename: Vincenzo Davide
authors.initials: VD
authors.lastname: Palumbo
authors.forename: Gabriele
authors.initials: G
authors.lastname: Spinelli
authors.forename: Giovanni
authors.initials: G
authors.lastname: Tomasello
authors.forename: Antonio
authors.initials: A
authors.lastname: Marrazzo
authors.forename: Silvia
authors.initials: S
authors.lastname: Ficarella
authors.forename: Antonio
authors.initials: A
authors.lastname: Bruno
authors.forename: Antonino
authors.initials: A
authors.lastname: Sammartano
authors.forename: Tiziana
authors.initials: T
authors.lastname: Fiorentini
authors.forename: Antonio
authors.initials: A
authors.lastname: Scio
authors.forename: Carolina
authors.initials: C
authors.lastname: Maione
authors.forename: Attilio Ignazio
authors.initials: AI
authors.lastname: Lo Monte
keywords: Antidepressant therapy; Hyperprolactinemia; Idiopathic granulomatous mastitis; Selective serotonin reuptake inhibitors