title: Exogenous L-lactate clearance in adult horses.
abstract: OBJECTIVE
  To determine endogenous production of L-lactate and the clearance of exogenous sodium L-lactate (ExLC) in healthy adult horses.
  
  
  METHODS
  A sodium L-lactate solution (1 mmol/kg body weight qs to 500 mL final volume in 0.9% NaCl) was adminstered IV over 15 minutes. Blood samples for L-lactate concentration [LAC] measurement were collected immediately prior to infusion, at 5, 10, and 15 minutes during infusion and at 1 minute intervals for 15 minutes, at 30, 45, 60, 120, and 180 minutes postinfusion. Disposition modeling and pharmacokinetic analysis was performed using proprietary software.
  
  
  METHODS
  University Teaching Hospital.
  
  
  METHODS
  Six clinically healthy adult horses.
  
  
  RESULTS
  Median (range) baseline [LAC] was 0.43 (0.20-0.72) mmol/L for samples obtained every 3 hours over the 24 hours prior to ExLC and demonstrated variability primarily associated with horse. Median [LAC] immediately prior to ExLC was 0.43 (0.35-0.52) mmol/L. A 2-compartment model was used to specify the pharmacokinetic parameters. Median (range) ExLC was 1.05 (0.073-1.75) L·h(-1) ·kg(-1)  and t(1/2)  β was 29.54 (20.8-38.6) min. Median lactate production based on basal [LAC] immediately prior to ExLC was was 0.49 (0.31-0.93) mmol·h(-1) ·kg(-1) .
  
  
  CONCLUSIONS
  ExLC in healthy adult horses is greater than that of hyperlactemic human patients but similar to normolactemic-sick human patients examined using the same model, supporting development of species, and disease specific ExLC parameters.
authors.affiliation: Department of Veterinary Clinical Medicine, University of Illinois at Urbana-Champaign, 1008W. Hazelwood Drive, Urbana, IL 61802, USA.
authors.forename: Pedro
authors.initials: P
authors.lastname: De Pedro
authors.forename: Pamela A
authors.initials: PA
authors.lastname: Wilkins
authors.forename: Maureen A
authors.initials: MA
authors.lastname: McMichael
authors.forename: Levent
authors.initials: L
authors.lastname: Dirikolu
authors.forename: Kara M
authors.initials: KM
authors.lastname: Lascola
authors.forename: Stuart C
authors.initials: SC
authors.lastname: Clark-Price
authors.forename: Raymond C
authors.initials: RC
authors.lastname: Boston
mesh_terms: D000818:Animals; D005260:Female; D006736:Horses / Q000097:blood / Q000378:metabolism*; D019344:Lactic Acid / Q000097:blood / Q000378:metabolism*; D008297:Male; D019354:Sodium Lactate / Q000008:administration & dosage* / Q000378:metabolism
chemical_list: D019344:Lactic Acid; D019354:Sodium Lactate