title: Novel macrocyclic monoterpene glycosides from bioactive extract of Parkinsonia aculeata L.
abstract: Five novel macrocyclic monoterpene O-glycosides, parkinsenes A-E (1-5), and eleven known phenolic metabolites including three 3-O-glycosylflavonols (6-8), five C-glycosylflavones (9-13), p-hydroxybenzoic acid (14), esculetin (15), and diosmetin (16) were isolated from the leaves and small twigs of Parkinsonia aculeata L. (Fabaceae). Their structures were established by chemical and spectroscopic analyses (UV, ESI-MS, and 1D/2D NMR). The investigated 80 % aqueous methanol extract (AME) showed significant analgesic, antipyretic, anti-inflammatory, hepatoprotective, hypoglycemic, hypocholesterolemic, and antioxidant activities in a dose-dependent manner using two different doses 250 and 500 mg/kg b. wt.
authors.affiliation: Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, P. O. Box 2457, Riyadh, 11451, Saudi Arabia. msmarzouk@yahoo.co.uk
authors.forename: M S
authors.initials: MS
authors.lastname: Marzouk
authors.forename: F A
authors.initials: FA
authors.lastname: Moharram
authors.forename: R A
authors.initials: RA
authors.lastname: El Dib
authors.forename: D G
authors.initials: DG
authors.lastname: El-Hossary
mesh_terms: D000700:Analgesics / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000737:chemistry / Q000302:isolation & purification / Q000627:therapeutic use; D000975:Antioxidants / Q000737:chemistry / Q000302:isolation & purification / Q000627:therapeutic use; D058633:Antipyretics / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use; D001831:Body Temperature / Q000187:drug effects; D004195:Disease Models, Animal; D004487:Edema / Q000139:chemically induced / Q000188:drug therapy; D007887:Fabaceae / Q000737:chemistry*; D005260:Female; D006027:Glycosides / Q000737:chemistry* / Q000302:isolation & purification; D006937:Hypercholesterolemia / Q000188:drug therapy; D007035:Hypothermia / Q000188:drug therapy; D047028:Macrocyclic Compounds / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D008968:Molecular Conformation; D039821:Monoterpenes / Q000737:chemistry*; D018515:Plant Leaves / Q000737:chemistry; D051381:Rats; D021241:Spectrometry, Mass, Electrospray Ionization
chemical_list: D000700:Analgesics; D000893:Anti-Inflammatory Agents; D000975:Antioxidants; D058633:Antipyretics; D006027:Glycosides; D047028:Macrocyclic Compounds; D039821:Monoterpenes