title: [Disseminated histoplasmosis, lymphopenia and Sjögren's syndrome].
abstract: Sjögren's syndrome is an autoimmune disease characterized by decreased exocrine gland secretions; patients may also present several hematological abnormalities, like lymphopenia. We describe the case of a 28 year old man who complained of headache a month of duration, with fever and vomiting in the last 48 hours. He also presented skin lesions on trunk and face, without neck stiffness. The diagnosis of duration infection was confirmed by culture from the skin biopsy and spinal fluid specimens; in addition, the presence of lymphopenia, positive anti Ro-SSA antibodies, poor concentration of the tracer in scintigraphy and lymphocytic infiltration in salivary glands confirmed the diagnosis of Sjögren's syndrome. the patient was successfully treated with liposomal amphotericin and itraconazole. We report this case to emphasize that opportunistic infections, such as disseminated histoplasmosis, may be an uncommon clinical presentation of Sjögren's syndrome.
authors.affiliation: Servicio de Clínica Médica, Sala D, Hospital Interzonal General de Agudos Gral. San Martín, La Plata, Buenos Aires, Argentina. hrodrigo@intramed.net
authors.forename: Horacio F
authors.initials: HF
authors.lastname: Rodrigo
authors.forename: Rodolfo N
authors.initials: RN
authors.lastname: Stavile
authors.forename: Sabino
authors.initials: S
authors.lastname: Deleo
mesh_terms: D000328:Adult; D000666:Amphotericin B / Q000627:therapeutic use; D000935:Antifungal Agents / Q000627:therapeutic use; D006658:Histoplasma; D006660:Histoplasmosis / Q000150:complications* / Q000188:drug therapy; D006801:Humans; D017964:Itraconazole / Q000627:therapeutic use; D008231:Lymphopenia / Q000150:complications* / Q000188:drug therapy; D008297:Male; D012859:Sjogren's Syndrome / Q000150:complications* / Q000188:drug therapy
chemical_list: D000935:Antifungal Agents; C068538:liposomal amphotericin B; D017964:Itraconazole; D000666:Amphotericin B