title: [3'UTR +62G>A polymorphism of the RETN gene coding resistin and its association with metabolic syndrome components].
abstract: OBJECTIVE
  The polymorphism of the resistin gene (RETN/RSTN) has been associated with metabolic alterations. In this study the association between the 3'UTR +62G>A polymorphism and metabolic syndrome components was evaluated.
  
  
  METHODS
  The population (n=218) was distributed in 3 groups: the control group with no metabolic alterations (n=77), nSMA group with isolated metabolic alterations (n=94) and MS group with metabolic syndrome (n=47). The 3'UTR +62G>A polymorphism was analyzed by PCR-RFLP.
  
  
  RESULTS
  Central obesity was the most frequent alteration in both nSMA (56.4%) and MS (91.5%) groups followed by low c-HDL levels in the nSMA group (42.6%) and arterial hypertension in the MS group (85%). The frequency of the +62G/A genotype was 20.2% in the population. The G/A genotype was more frequently found in the MS (38.3%) and nSMA (17%) groups than in the control group (13%). The allelic distribution between the control group (+62G=0.94, +62A=0.06) and MS group (+62G=0.81, +62A=0.19) was significantly different (P=.0001). Significant associations between the G/A genotype and high values of abdominal circumference (P=.047), basal glycemia (P=.02) and systolic arterial pressure (P=.003) were found.
  
  
  CONCLUSIONS
  The findings suggest the association between the G/A genotype and high values of systolic arterial pressure, basal glycemia and abdominal circumference. This association was independent of the metabolic syndrome context.
authors.affiliation: Coordinación de la Sección de Biología Molecular, Centro de Investigaciones Endocrino-Metabólicas Dr. Félix Gómez, Facultad de Medicina, Universidad del Zulia, Maracaibo, Estado Zulia, Venezuela; Escuela de Bioanálisis, Facultad de Medicina, Universidad del Zulia, Maracaibo, Estado Zulia, Venezuela. Electronic address: narraiz1@gmail.com.
authors.forename: Nailet
authors.initials: N
authors.lastname: Arráiz
authors.forename: Carolina
authors.initials: C
authors.lastname: Escalona
authors.forename: Carem
authors.initials: C
authors.lastname: Prieto
authors.forename: Valmore
authors.initials: V
authors.lastname: Bermúdez
authors.forename: Endrina
authors.initials: E
authors.lastname: Mújica
authors.forename: María Patricia
authors.initials: MP
authors.lastname: Sánchez
authors.forename: Andrea
authors.initials: A
authors.lastname: Mújica
mesh_terms: D020413:3' Untranslated Regions; D000293:Adolescent; D000328:Adult; D000368:Aged; D016022:Case-Control Studies; D005260:Female; D005819:Genetic Markers; D005838:Genotype; D006801:Humans; D006973:Hypertension / Q000235:genetics; D008297:Male; D024821:Metabolic Syndrome / Q000235:genetics*; D008875:Middle Aged; D056128:Obesity, Abdominal / Q000235:genetics; D020641:Polymorphism, Single Nucleotide; D052243:Resistin / Q000235:genetics*; D055815:Young Adult
chemical_list: D020413:3' Untranslated Regions; D005819:Genetic Markers; C499624:RETN protein, human; D052243:Resistin
keywords: 3’UTR 62G/A; Metabolic syndrome; RETN; Resistin; Resistina; Síndrome metabólico; rs3745368