title: [Expression and clinical significance of Claudin-1 and Claudin-4 in colorectal cancer tissues].
abstract: OBJECTIVE
  To investigate the expression of tight junction protein Claudin-1 and Claudin-4 in colorectal cancer tissues and its clinical significance.
  
  
  METHODS
  Immunohistochemical staining detected the expression of tight junction protein Claudin-1 and Claudin-4 in 60 cases of colorectal cancer and 20 normal colorectal mucosa tissue. The clinical significance was analyzed.
  
  
  RESULTS
  The positive rates of Claudin-1 and Claudin-4 in colorectal cancer tissues were 76.6%(46/60) and 85.0%(51/60), significantly higher than 20.0% (4/20) and 30.0%(6/20) in the normal colorectal mucosa(both P<0.01). The positive rates of Claudin-1 and Claudin-4 were associated with tumor differentiation degree, lymph node metastasis and TNM staging(all P<0.05).
  
  
  CONCLUSIONS
  The high expression of the Claudin-1 and Claudin-4 may play a promoting role in colorectal cancer development and progression.  Claudin-1 and Claudin-4 may become prognostic markers of colorectal cancer.
authors.affiliation: Department of General Surgery, Beijing Command General Hospital, Beijing, China.
authors.forename: Lin
authors.initials: L
authors.lastname: Wang
authors.forename: Shi-yong
authors.initials: SY
authors.lastname: Li
authors.forename: Ping
authors.initials: P
authors.lastname: An
authors.forename: Hui-yun
authors.initials: HY
authors.lastname: Cai
mesh_terms: D062445:Claudin-1 / Q000032:analysis*; D062506:Claudin-4 / Q000032:analysis*; D015179:Colorectal Neoplasms / Q000737:chemistry*; D018450:Disease Progression; D006801:Humans; D008207:Lymphatic Metastasis; D009367:Neoplasm Staging
chemical_list: D062445:Claudin-1; D062506:Claudin-4