title: The proper use of acetaminophen.
abstract: Acetaminophen (N-acetyl-p-aminophenol, paracetamol [APAP])-induced acute liver failure is the most common cause of acute liver failure in adults. In children, APAP accounts for 25% of all cases of acute liver failure. The high mortality rate associated with this preventable condition makes it vital that paediatricians are aware of the potential adverse effects associated with this widely used drug. While APAP is generally considered to be safe when used as directed, its inclusion in multiple over-the-counter medications, as well as in prescription drugs, mandates that physicians promote and educate the general public about the proper use of acetaminophen in children.
authors.affiliation: Department of Pediatrics, University of Arkansas for Medical Sciences, Section of Clinical Pharmacology and Toxicology, Arkansas Children's Hospital, Little Rock, Arkansas;
authors.forename: Laura
authors.initials: L
authors.lastname: James
authors.forename: Janice E
authors.initials: JE
authors.lastname: Sullivan
authors.forename: Dean
authors.initials: D
authors.lastname: Roberts
keywords: Adducts; Children; Hepatitis; Liver; Safety