title: [No evidence for renal protective effect of loop diuretics for patients having oliguria].
abstract: In many intensive care units, loop diuretics are used more or less routinely to achieve a urinary output above 1 ml/kg/h in critically ill patients. We do not in the literature find any basis of this strategy. In contrast, this practice may cause a risk of circulatory instability in the critically ill patient due to large diuresis and volume depletion. There is no evidence so far that the use of loop diuretics has a renal protective effect or any other beneficial impact on the renal function. The use of loop diuretics in oliguric critically ill patients may be harmful. Consequently an individual assessment is required.
authors.affiliation: Anæstesi/intensiv Afdeling I, Aarhus Universitetshospital, Skejby, Brendstrupgårdsvej 100, Aarhus.
authors.forename: Charlotte
authors.initials: C
authors.lastname: Runge Sørensen
authors.forename: Jens Kristian
authors.initials: JK
authors.lastname: Madsen
authors.forename: Frank
authors.initials: F
authors.lastname: Schmidt
authors.forename: Erik
authors.initials: E
authors.lastname: Sloth
mesh_terms: D058186:Acute Kidney Injury / Q000188:drug therapy* / Q000503:physiopathology; D016638:Critical Illness; D004231:Diuresis / Q000187:drug effects; D019317:Evidence-Based Medicine; D005440:Fluid Therapy / Q000379:methods; D005665:Furosemide / Q000009:adverse effects / Q000494:pharmacology* / Q000627:therapeutic use; D006801:Humans; D007362:Intensive Care Units; D007668:Kidney / Q000187:drug effects*; D009846:Oliguria / Q000188:drug therapy* / Q000503:physiopathology; D051437:Renal Insufficiency / Q000188:drug therapy / Q000503:physiopathology; D012307:Risk Factors; D049994:Sodium Potassium Chloride Symporter Inhibitors / Q000009:adverse effects / Q000494:pharmacology* / Q000627:therapeutic use
chemical_list: D049994:Sodium Potassium Chloride Symporter Inhibitors; D005665:Furosemide