title: Contribution of the complement system to realization of biological fluid cytotoxicity in health and disease.
abstract: The cytotoxic effects of human blood serum were studied under normal and pathological conditions. The contribution of the complement system to the realization of this effect was demonstrated. Significant differences in the serum capacity to kill foreign cells were detected for healthy subjects and asthmatics. Bovine sperm suspension can serve as the test object for rapid evaluation of functional activity of the complement system.
authors.affiliation: Institute of Pathology and Pathophysiology, the Russian Academy of Medical Sciences, PK Anokhin Institute of Physiology, the Russian Academy of Medical Sciences, Moscow, Russia. labpolys@gmail.com
authors.forename: E N
authors.initials: EN
authors.lastname: Arkhipova
authors.forename: A B
authors.initials: AB
authors.lastname: Cherepov
authors.forename: Yu S
authors.initials: YS
authors.lastname: Medvedeva
authors.forename: I B
authors.initials: IB
authors.lastname: Alchinova
authors.forename: M Yu
authors.initials: MY
authors.lastname: Karganov
mesh_terms: D000818:Animals; D001249:Asthma / Q000276:immunology*; D056352:Athletes; D002417:Cattle; D003165:Complement System Proteins / Q000276:immunology / Q000378:metabolism / Q000494:pharmacology*; D003603:Cytotoxins / Q000276:immunology / Q000378:metabolism / Q000494:pharmacology*; D005665:Furosemide; D006493:Heparin; D006801:Humans; D008297:Male; D044967:Serum / Q000276:immunology* / Q000378:metabolism; D013081:Sperm Motility / Q000187:drug effects
chemical_list: D003603:Cytotoxins; D005665:Furosemide; D006493:Heparin; D003165:Complement System Proteins