title: Identifying crosstalk of mTOR signaling pathway of lobular breast carcinomas.
abstract: BACKGROUND
  Invasive lobular carcinoma (ILC) and its variants represent 5% to 15% of all invasive breast cancers diagnoses annually. AS a serine/threonine kinase, mammalian target of rapamycin (mTOR) is often a downstream effector of PI3K/Akt (phosphatidyl inositol 3-kinase/protein kinase B) signaling pathway in breasts and many types of cancer cells. Therefore, agents that target mTOR in direct or indirect manner are being developed in anti-cancer therapy.
  
  
  OBJECTIVE
  In this study, our objective here was to explore more crosstalk pathway with mTOR signaling pathway.
  
  
  METHODS
  We collected pathways data from published database, then based on bioinformatics methods we analyzed the significant pathways in the database, additionally, the crosstalk pathways were also analyzed which were defined as those pathways which have the overlapping genes with each other.
  
  
  RESULTS
  As we expected, the results showed that Notch signaling pathway (hsa04330), Regulation of autophagy (hsa04140), and Adipocytokine signaling pathway (hsa04920) were linked to mTOR signaling pathway. All of them have been demonstrated participate in breast cancer progression.
  
  
  CONCLUSIONS
  We obtained some key pathways that crosstalked with mTOR signaling pathway, we hope our study could provide novel therapeutic approaches for breast cancer.
authors.affiliation: Department of Breast and Head-Neck Surgery, Cancer Hospital Affiliated to Xinjiang Medical University, Xinjiang Institute of Cancer Research, Urumqi, Xinjiang, China. mabinlin@gmail.com
authors.forename: G
authors.initials: G
authors.lastname: Sun
authors.forename: M H
authors.initials: MH
authors.lastname: Shan
authors.forename: B L
authors.initials: BL
authors.lastname: Ma
authors.forename: Z L
authors.initials: ZL
authors.lastname: Geng
authors.forename: A
authors.initials: A
authors.lastname: Alibiyati
authors.forename: H
authors.initials: H
authors.lastname: Zhong
authors.forename: J
authors.initials: J
authors.lastname: Wang
authors.forename: G H
authors.initials: GH
authors.lastname: Ren
authors.forename: H T
authors.initials: HT
authors.lastname: Li
authors.forename: C
authors.initials: C
authors.lastname: Dong
mesh_terms: D054392:Adipokines / Q000502:physiology; D001343:Autophagy; D001943:Breast Neoplasms / Q000378:metabolism*; D018275:Carcinoma, Lobular / Q000378:metabolism*; D005260:Female; D006801:Humans; D009285:Naphthoquinones / Q000494:pharmacology; D015398:Signal Transduction; D058570:TOR Serine-Threonine Kinases / Q000502:physiology*
chemical_list: D054392:Adipokines; D009285:Naphthoquinones; C546842:MTOR protein, human; D058570:TOR Serine-Threonine Kinases; C014758:plumbagin