title: Reference ranges for vertebral body areas of the fetal lumbosacral spine on 3-dimensional sonography using volume contrast imaging with OmniView.
abstract: OBJECTIVES; The purpose of this study was to establish reference ranges for vertebral body areas of the fetal lumbosacral spine in the coronal plane on 3-dimensional sonography using volume contrast imaging with OmniView (GE Healthcare, Zipf, Austria). METHODS; An observational cross-sectional study was conducted on 576 healthy pregnant women at gestational ages of 20 weeks to 34 weeks 6 days. Volume contrast imaging with OmniView was used to measure the vertebral body areas (L1-L5, S1, and S2) by positioning a curved line along the fetal lumbosacral spine. To create reference ranges, first- and second-degree linear regression models adjusted using residual analysis and the coefficient of determination (R(2)) were created. To assess reproducibility, two examiners evaluated 40 random volumes using the intraclass correlation coefficient. RESULTS; The mean areas of the vertebral bodies were 102.72 (range, 25-254), 107.29 (range, 30-245), 105.10 (range, 31-231), 99.09 (range, 31-211), 87.74 (range, 11-178), 65.80 (range, 18-161), and 46.54 (range, 12-129) mm(2) for L1, L2, L3, L4, L5, S1, and S2, respectively. In the intraobserver and interobserver reproducibility assessments, intraclass correlation coefficients of greater than 0.80 were found for all fetal vertebral body areas. CONCLUSIONS; Reference values for fetal lumbosacral spine vertebral body areas were determined by 3-dimensional sonography using volume contrast imaging with OmniView, and they were shown to be reproducible.
authors.affiliation: Department of Obstetrics, Federal University of São Paulo, 05303-000 São Paulo-SP, Brazil.
authors.forename: Luis Henrique
authors.initials: LH
authors.lastname: Martinez
authors.forename: Edward
authors.initials: E
authors.lastname: Araujo Júnior
authors.forename: Christiane
authors.initials: C
authors.lastname: Simioni
authors.forename: Luciano Marcondes Machado
authors.initials: LM
authors.lastname: Nardozza
authors.forename: Antonio Fernandes
authors.initials: AF
authors.lastname: Moron
mesh_terms: D001938:Brazil / Q000453:epidemiology; D003287:Contrast Media; D005260:Female; D006801:Humans; D021621:Imaging, Three-Dimensional / Q000592:standards* / Q000706:statistics & numerical data; D008159:Lumbar Vertebrae / Q000000981:diagnostic imaging* / Q000196:embryology; D008161:Lumbosacral Region / Q000000981:diagnostic imaging / Q000196:embryology*; D008297:Male; D009929:Organ Size; D011247:Pregnancy; D012016:Reference Values; D015203:Reproducibility of Results; D012447:Sacrum / Q000000981:diagnostic imaging* / Q000196:embryology; D012680:Sensitivity and Specificity; D012984:Software / Q000592:standards*; D016216:Ultrasonography, Prenatal / Q000592:standards* / Q000706:statistics & numerical data
chemical_list: D003287:Contrast Media