title: Association between Insulin Resistance, Metabolic Syndrome and Nonalcoholic Fatty Liver Disease in Chinese Adults.
abstract: BACKGROUND
  The aim of this study was to assess the association between insulin resistance, metabolic syndrome and nonalcoholic fatty liver disease (NAFLD) in Chinese adults.
  
  
  METHODS
  Fifty five subjects with NAFLD and 55 controls were enrolled for the study. Waist circumference, blood pressure, plasma triglyceride, high density lipoprotein cholesterol and fasting plasma glucose concentrations and homeostasis model assessment of insulin resistance (HOMA-IR) values as an index used to quantify insulin resistance were measured and analyzed. Logistic regression was analyzed to predict independent risk factors of NAFLD.
  
  
  RESULTS
  The prevalence of metabolic syndrome in NAFLD group was obviously higher than in controls group (47.3% VS 3.6%, P<0.001). There were all significant differences of each component of metabolic syndrome and HOMA-IR values in comparison of nonalcoholic fatty liver disease (NAFLD) and controls group. In a logistic regression analysis, age, diastolic blood pressure, waist circumference and HOMA-IR were the covariates independently associated with the presence of NAFLD (Odds Ratio=1.107, 1.083, 1.218 and 16.836; 95% CI: 1.011∼1.211, 1.001∼1.173, 1.083∼1.370 and 3.626∼78.168, respectively; P<0.05)
  
  
  CONCLUSIONS
  NAFLD was closely associated with metabolic syndrome and insulin resistance was a very strong predictor of NAFLD.
authors.affiliation: International Healthcare Center, the Second Affiliated Hospital, School of Medicine, Zhejiang University, 310009, Hangzhou, China.
authors.forename: Xin
authors.initials: X
authors.lastname: Ying
authors.forename: Yan
authors.initials: Y
authors.lastname: Jiang
authors.forename: Yafang
authors.initials: Y
authors.lastname: Qian
authors.forename: Zhenyan
authors.initials: Z
authors.lastname: Jiang
authors.forename: Zhenya
authors.initials: Z
authors.lastname: Song
authors.forename: Changjun
authors.initials: C
authors.lastname: Zhao
keywords: China; Insulin Resistance; Metabolic syndrome; Nonalcoholic Fatty Liver Disease