title: Sinonasal inflammation in COPD: a systematic review.
abstract: In this review, we demonstrate that patients with chronic obstructive pulmonary disease (COPD) frequently report sinonasal symptoms. Furthermore, we present evidence that smoking on its own can cause nasal disease and that, in COPD patients, nasal inflammation mimics that of the bronchi. All this evidence suggests that COPD-related sinonasal disease does exist and that smoking on its own rather than systemic inflammation triggers the condition. However, COPD-related sinonasal disease remains to be characterised in terms of symptoms and endoscopic findings. In addition, more studies are needed to quantify the negative impact of sinonasal symptoms on the quality of life in COPD patients.
authors.affiliation: Head & Neck Surgery and Audiology, Rigshospitalet and Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen.
authors.forename: Kåre
authors.initials: K
authors.lastname: Håkansson
authors.forename: Lars
authors.initials: L
authors.lastname: Konge
authors.forename: Simon F
authors.initials: SF
authors.lastname: Thomsen
authors.forename: Vibeke
authors.initials: V
authors.lastname: Backer
authors.forename: Christian
authors.initials: C
authors.lastname: von Buchwald
mesh_terms: D001980:Bronchi / Q000473:pathology; D004724:Endoscopy; D006801:Humans; D007249:Inflammation / Q000150:complications*; D017817:Nasal Lavage Fluid; D010256:Paranasal Sinuses / Q000473:pathology; D029424:Pulmonary Disease, Chronic Obstructive / Q000150:complications* / Q000503:physiopathology; D011788:Quality of Life; D012220:Rhinitis / Q000150:complications* / Q000503:physiopathology; D012852:Sinusitis / Q000150:complications* / Q000503:physiopathology; D012907:Smoking / Q000009:adverse effects