title: Rheumatoid neutrophilic dermatosis with tense blister formation: a case report and review of the literature.
abstract: We report a 78-year-old woman with rheumatoid neutrophilic dermatosis (RND) presenting with tense blisters; an extremely rare manifestation of this condition. Systemic corticosteroid was of limited efficacy, while dapsone was effective. A literature review of four similar cases showed that tense blisters in this type of RND tended to appear on the lower extremities of aged, female rheumatoid arthritis patients. Of note, half of the cases were resistant to corticosteroids, as anti-neutrophil agents are reported to be effective. Accordingly, it is important to recognise this unusual manifestation for the timely initiation of appropriate therapy.
authors.affiliation: Department of Dermatology, Keio University School of Medicine, Tokyo, Japan.
authors.forename: Yumi
authors.initials: Y
authors.lastname: Fujio
authors.forename: Takeru
authors.initials: T
authors.lastname: Funakoshi
authors.forename: Kaori
authors.initials: K
authors.lastname: Nakayama
authors.forename: Masayuki
authors.initials: M
authors.lastname: Amagai
authors.forename: Manabu
authors.initials: M
authors.lastname: Ohyama
mesh_terms: D000368:Aged; D000890:Anti-Infective Agents / Q000627:therapeutic use; D001172:Arthritis, Rheumatoid / Q000150:complications*; D001768:Blister / Q000188:drug therapy / Q000209:etiology*; D003622:Dapsone / Q000627:therapeutic use; D003872:Dermatitis / Q000150:complications* / Q000473:pathology*; D005260:Female; D006801:Humans; D020556:Neutrophil Infiltration
chemical_list: D000890:Anti-Infective Agents; D003622:Dapsone
keywords: blister formation; bullous pemphigoid; neutrophilic dermatosis; rheumatoid arthritis