title: Antiulcerogenic activities of the extracts and isolated flavonoids of Euphorbia cuneata Vahl.
abstract: The total alcohol extracts of Euphorbia cuneata Vahl.(Euphorbiaceae) were screened for antiulcerogenic activity using an ethanol-induced ulcer model at doses of 125, 250 and 500 mg/kg. The extracts possessed antiulcerogenic activity in a dose-dependent manner. Four flavonoidal compounds were isolated and identified as naringenin, aromadendrin, apigenin and 4'-O-methoxy-luteolin-7-O-rhamnoglucoside, each demonstrating antiulcerogenic activity with curative ratios ranging from 75.78% to 88.23%. In addition, the alcohol extracts and isolated compounds were shown to scavenge the 1,1-diphenyl,2-picrylhydrazyl radical by different ratio, with the most effective being 4'-O-methoxy-luteolin-7-O-rhamnoglucoside (91.14%). The antioxidant activity of the alcohol extracts and the isolated compounds may explain the antiulcerogenic properties. No side effects were observed on either liver or kidney functions.
authors.affiliation: Chemistry Department, Faculty of Science, King Saud University, Riyadh, KSA. amaniawaad@hotmail.com
authors.forename: Amani S
authors.initials: AS
authors.lastname: Awaad
authors.forename: Nabilah A
authors.initials: NA
authors.lastname: Al-Jaber
authors.forename: John E
authors.initials: JE
authors.lastname: Moses
authors.forename: Reham M
authors.initials: RM
authors.lastname: El-Meligy
authors.forename: Mohamed E
authors.initials: ME
authors.lastname: Zain
mesh_terms: D000818:Animals; D000897:Anti-Ulcer Agents / Q000302:isolation & purification / Q000494:pharmacology*; D000975:Antioxidants / Q000494:pharmacology; D047310:Apigenin / Q000494:pharmacology; D028481:Euphorbia / Q000737:chemistry*; D044950:Flavanones / Q000494:pharmacology; D005419:Flavonoids / Q000302:isolation & purification / Q000494:pharmacology*; D007668:Kidney / Q000187:drug effects; D008099:Liver / Q000187:drug effects; D047311:Luteolin / Q000494:pharmacology; D008297:Male; D010936:Plant Extracts / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar
chemical_list: C580563:4'-O-methoxy-luteolin-7-O-rhamnoglucoside; D000897:Anti-Ulcer Agents; D000975:Antioxidants; D044950:Flavanones; D005419:Flavonoids; D010936:Plant Extracts; D047310:Apigenin; C080220:aromadedrin; C005273:naringenin; D047311:Luteolin