title: Evaluating the performance of fibronectin 1 (FN1), integrin α4β1 (ITGA4), syndecan-2 (SDC2), and glycoprotein CD44 as the potential biomarkers of oral squamous cell carcinoma (OSCC).
abstract: OBJECTIVE
  Some extracellular matrix genes as prognostic biomarkers for oral squamous cell carcinoma (OSCC) were evaluated.
  
  
  METHODS
  We investigated gene expression of fibronectin 1 (FN1), integrin α4β1 (ITGA4), syndecan-2 (SDC2), and glycoprotein CD44 in matched OSCC/margin tissues.
  
  
  RESULTS
  Areas under receiver-operating characteristic curves (AUCs) of relative mRNA expression of FN1, ITGA4, SDC2, and CD44 were 0.700, 0.677, 0.513, and 0.549, respectively. For tongue/mouth floor and edentulous ridge, AUC for FN1 and ITGA4 were 0.827 and 0.725 and sensitivities/specificities were 80%/84% and 88%/52%, respectively.
  
  
  CONCLUSIONS
  FN1 and ITGA4 are potential OSCC biomarkers for tongue/mouth floor and edentulous ridge.
authors.affiliation: Department of Oral and Maxillofacial Surgery, Chi-Mei Medical Center, Tainan, Taiwan.
authors.forename: Ching-Yu
authors.initials: CY
authors.lastname: Yen
authors.forename: Chien-Yang
authors.initials: CY
authors.lastname: Huang
authors.forename: Ming-Feng
authors.initials: MF
authors.lastname: Hou
authors.forename: Yi-Hsin
authors.initials: YH
authors.lastname: Yang
authors.forename: Chao-Hsiang
authors.initials: CH
authors.lastname: Chang
authors.forename: Hurng-Wern
authors.initials: HW
authors.lastname: Huang
authors.forename: Chung-Ho
authors.initials: CH
authors.lastname: Chen
authors.forename: Hsueh-Wei
authors.initials: HW
authors.lastname: Chang
mesh_terms: D000328:Adult; D014408:Biomarkers, Tumor / Q000378:metabolism*; D002294:Carcinoma, Squamous Cell / Q000378:metabolism*; D016022:Case-Control Studies; D005260:Female; D005353:Fibronectins / Q000378:metabolism*; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D018960:Hyaluronan Receptors / Q000378:metabolism*; D039041:Integrin alpha4beta1 / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D009055:Mouth / Q000378:metabolism; D009062:Mouth Neoplasms / Q000378:metabolism*; D012680:Sensitivity and Specificity; D053669:Syndecan-2 / Q000378:metabolism*
chemical_list: D014408:Biomarkers, Tumor; C497483:CD44 protein, human; C067625:FN1 protein, human; D005353:Fibronectins; D018960:Hyaluronan Receptors; D039041:Integrin alpha4beta1; D053669:Syndecan-2