title: [Research progress of protein tyrosine phosphatase SHP-2].
abstract: The Src homology-2 domain-containing phosphatase SHP-2 encoded by PTPN11 is an essential component in several signaling pathways.Different types of mutation in SHP-2 have     been confirmed in several types of leukemia and solid tumors. Elucidation of the events underlying Shp2-evoked transformation may provide new insights into the novel targets     for anti-cancer therapy.
authors.affiliation: Department of Surgical Oncology, Zhejiang University School of Medicine, Hangzhou, China.
authors.forename: Hong-ke
authors.initials: HK
authors.lastname: Cai
authors.forename: Yong-chuan
authors.initials: YC
authors.lastname: Deng
mesh_terms: D006801:Humans; D054592:Protein Tyrosine Phosphatase, Non-Receptor Type 11 / Q000737:chemistry / Q000378:metabolism / Q000502:physiology
chemical_list: D054592:Protein Tyrosine Phosphatase, Non-Receptor Type 11