title: The confirmation of three repeated sequence elements in the 3' untranslated region of Chikungunya virus.
abstract: In this study, the complete genomic nucleotide sequence of Chikungunya virus (CHIKV) strain S27 African prototype was determined and three 21 nucleotides repeated sequence elements (RSEs) at positions 11398-11418, 11533-11553, and 11620-11640 in the 3' untranslated region (3'UTR) were confirmed. In addition, the 3'UTRs of all CHIKV strains deposited in GenBank were analyzed. The results displayed that the majority of the CHIKV strains consisted of the three 21 nucleotides RSEs in the 3'UTRs, and the third RSE was the most conservative. The conservation of the three RSEs of 21 nucleotides within the 3'UTR of CHIKV genome may play an important role on the virus replication cycle.
authors.affiliation: State Key Laboratory of Pathogens and Biosecurity, Beijing Institute of Microbiology and Epidemiology, 20 Dongda Street, Fengtai District, Beijing, China.
authors.forename: Yu
authors.initials: Y
authors.lastname: Zhang
authors.forename: Bing-Yin
authors.initials: BY
authors.lastname: Si
authors.forename: Xiao-Ping
authors.initials: XP
authors.lastname: Kang
authors.forename: Yi
authors.initials: Y
authors.lastname: Hu
authors.forename: Jing
authors.initials: J
authors.lastname: Li
authors.forename: Xiao-Yan
authors.initials: XY
authors.lastname: Wu
authors.forename: Yu-Chang
authors.initials: YC
authors.lastname: Li
authors.forename: Yin-Hui
authors.initials: YH
authors.lastname: Yang
authors.forename: Qing-Yu
authors.initials: QY
authors.lastname: Zhu
mesh_terms: D020413:3' Untranslated Regions; D018354:Alphavirus Infections / Q000453:epidemiology / Q000821:virology; D065632:Chikungunya Fever; D002646:Chikungunya virus / Q000235:genetics* / Q000302:isolation & purification; D004196:Disease Outbreaks; D016679:Genome, Viral; D006801:Humans; D008969:Molecular Sequence Data; D012367:RNA, Viral / Q000235:genetics*; D012091:Repetitive Sequences, Nucleic Acid; D017422:Sequence Analysis, DNA; D013636:Tanzania / Q000453:epidemiology
chemical_list: D020413:3' Untranslated Regions; D012367:RNA, Viral