title: Primary intestinal-like adenocarcinoma of major salivary glands: 2 instances of previously undocumented phenotype.
abstract: BACKGROUND
  Primary intestinal-like adenocarcinoma of the major salivary glands has not previously been reported.
  
  
  METHODS
  The clinical and radiological findings of 2 patients with primary submandibular and sublingual tumors are presented. Histopathologic and immunohistochemical examinations of tumor sections were performed. Metastatic workup for distant occult primary was carried out.
  
  
  RESULTS
  The light-optic and the immunomarkers revealed intestinal-like adenocarcinoma consistent with upper respiratory tract origin. Metastatic workup of both patients was negative for primary gastro-intestinal primary.
  
  
  CONCLUSIONS
  Primary intestinal-like adenocarcinoma can develop in major salivary glands and should be considered in the differential diagnosis.
authors.affiliation: Department of Head and Neck Surgery, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030-4009, USA.
authors.forename: Ann M
authors.initials: AM
authors.lastname: Gillenwater
authors.forename: Steven J
authors.initials: SJ
authors.lastname: Frank
authors.forename: Hanadi
authors.initials: H
authors.lastname: Fatani
authors.forename: Adel K
authors.initials: AK
authors.lastname: El-Naggar
mesh_terms: D000230:Adenocarcinoma / Q000473:pathology* / Q000628:therapy*; D000369:Aged, 80 and over; D006801:Humans; D008297:Male; D008875:Middle Aged; D013362:Sublingual Gland Neoplasms / Q000473:pathology* / Q000628:therapy*; D013365:Submandibular Gland Neoplasms / Q000473:pathology* / Q000628:therapy*
keywords: colonic-type adenocarcinoma; histogenesis; metastasis; salivary adenocarcinoma; salivary gland tumors