title: Bioplasmonic paper as a platform for detection of kidney cancer biomarkers.
abstract: We demonstrate that a common laboratory filter paper uniformly adsorbed with biofunctionalized plasmonic nanostructures can serve as a highly sensitive transduction platform for rapid detection of trace bioanalytes in physiological fluids. In particular, we demonstrate that bioplasmonic paper enables rapid urinalysis for the detection of kidney cancer biomarkers in artificial urine down to a concentration of 10 ng/mL. Compared to conventional rigid substrates, bioplasmonic paper offers numerous advantages such as high specific surface area (resulting in large dynamic range), excellent wicking properties (naturally microfluidic), mechanical flexibility, compatibility with conventional printing approaches (enabling multiplexed detection and multimarker biochips), and significant cost reduction.
authors.affiliation: Department of Mechanical Engineering and Materials Science, Washington University in St. Louis, St. Louis, Missouri 63130, United States.
authors.forename: Limei
authors.initials: L
authors.lastname: Tian
authors.forename: Jeremiah J
authors.initials: JJ
authors.lastname: Morrissey
authors.forename: Ramesh
authors.initials: R
authors.lastname: Kattumenu
authors.forename: Naveen
authors.initials: N
authors.lastname: Gandra
authors.forename: Evan D
authors.initials: ED
authors.lastname: Kharasch
authors.forename: Srikanth
authors.initials: S
authors.lastname: Singamaneni
mesh_terms: D000327:Adsorption; D000818:Animals; D014408:Biomarkers, Tumor / Q000302:isolation & purification / Q000652:urine*; D005374:Filtration; D006046:Gold / Q000737:chemistry; D006801:Humans; D007074:Immunoglobulin G / Q000737:chemistry; D007680:Kidney Neoplasms / Q000652:urine*; D057230:Limit of Detection; D043942:Nanotubes / Q000737:chemistry; D010209:Paper; D020349:Surface Plasmon Resonance / Q000295:instrumentation / Q000379:methods*; D016482:Urinalysis / Q000295:instrumentation / Q000379:methods*
chemical_list: D014408:Biomarkers, Tumor; D007074:Immunoglobulin G; D006046:Gold