title: Transient receptor potential channels in bladder function.
abstract: The transient receptor potential (TRP) superfamily of cationic ion channels includes proteins involved in the transduction of several physical and chemical stimuli to finely tune physiological functions. In the urinary bladder, they are highly expressed in, but not restricted to, primary afferent neurons. The urothelium and some interstitial cells also express several TRP channels. In this review, we describe the expression and the known roles of some members of TRP subfamilies, namely TRPV, TRPM and TRPA, in the urinary bladder. The therapeutic interest of modulating the activity of TRP channels to treat bladder dysfunctions is also discussed.
authors.affiliation: Department of Experimental Biology, Faculty of Medicine of University of Porto, Porto, Portugal.
authors.forename: A
authors.initials: A
authors.lastname: Avelino
authors.forename: A
authors.initials: A
authors.lastname: Charrua
authors.forename: B
authors.initials: B
authors.lastname: Frias
authors.forename: C
authors.initials: C
authors.lastname: Cruz
authors.forename: M
authors.initials: M
authors.lastname: Boudes
authors.forename: D
authors.initials: D
authors.lastname: de Ridder
authors.forename: F
authors.initials: F
authors.lastname: Cruz
mesh_terms: D000344:Afferent Pathways / Q000502:physiology*; D000818:Animals; D001341:Autonomic Nervous System / Q000502:physiology*; D006801:Humans; D056885:Interstitial Cells of Cajal / Q000502:physiology; D050051:Transient Receptor Potential Channels / Q000502:physiology*; D001743:Urinary Bladder / Q000294:innervation* / Q000502:physiology*
chemical_list: D050051:Transient Receptor Potential Channels