title: Intravascular optical coherence tomography to characterize tissue deformation during angioplasty: preliminary experiments with artery phantoms.
abstract: We explored the potential of intravascular optical coherence tomography (IVOCT) to assess deformation during angioplasty balloon inflation. Using a semi-compliant balloon and artery phantoms, we considered two experimental scenarios. The goal for the first scenario was to investigate if variation in the elasticity of the structure surrounding the balloon could be sensed by IVOCT monitoring. In this scenario, we used three single-layer phantoms with various mechanical properties. Image analysis was performed to extract the inner and outer diameters of the phantoms at various pressures. The goal for the second scenario was twofold. First, we investigated the IVOCT capability to monitor a more complex balloon inflation process. The balloon was in a folded state prior to inflation. This allowed studying two stages of deformation: during balloon unfolding and during balloon expansion. Second, we investigated IVOCT capability to monitor the deformation in a three-layer phantom used to better mimic a true artery. So, not only were the IVOCT images processed to provide the inner and outer diameters of the phantom, but the layer thicknesses were also determined. In both scenarios, IVOCT monitoring revealed to be very efficient in providing relevant information about the phantom deformation during balloon inflation.
authors.affiliation: Institut des Matériaux Industriels, Conseil National de Recherches Canada, 75 de Mortagne, Boucherville, Quebec J4B 6Y4, Canada.
authors.forename: Hamed
authors.initials: H
authors.lastname: Azarnoush
authors.forename: Sébastien
authors.initials: S
authors.lastname: Vergnole
authors.forename: Valérie
authors.initials: V
authors.lastname: Pazos
authors.forename: Charles-Étienne
authors.initials: CÉ
authors.lastname: Bisaillon
authors.forename: Benoit
authors.initials: B
authors.lastname: Boulet
authors.forename: Guy
authors.initials: G
authors.lastname: Lamouche
mesh_terms: D000800:Angioplasty, Balloon / Q000379:methods*; D000818:Animals; D001158:Arteries / Q000033:anatomy & histology / Q000502:physiology* / Q000601:surgery*; D055119:Elastic Modulus / Q000502:physiology; D057510:Endovascular Procedures; D006801:Humans; D019047:Phantoms, Imaging; D010865:Pilot Projects; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D025321:Surgery, Computer-Assisted / Q000379:methods*; D041623:Tomography, Optical Coherence / Q000379:methods*