title: Small cell cancer of the prostate.
abstract: De novo small cell cancer of the prostate is a rare tumor and has different presentation, behavior, and outcome compared with adenocarcinoma. A 66-year-old man presented with symptoms masquerading as a rectal tumor. Primary symptoms were intermittent constipation and diarrhea without any urinary symptoms. Initial staging showed only 2 large pelvic nodes. Prostate-specific antigen was 4.8 ng/L. A transrectal prostate biopsy confirmed small cell histology. After having no response to hormones and carboplatin-etoposide, a course of palliative radiotherapy, docetaxel chemotherapy, and defunctioning colostomy offered palliation. Liver and lytic bone metastases developed later; the patient died 9 months after the presentation.
authors.affiliation: Castle Hill Hospital, Hull and East Yorkshire NHS Trust, Hull, United Kingdom. sanjay.dixit@hey.nhs.uk
authors.forename: Sanjay
authors.initials: S
authors.lastname: Dixit
authors.forename: Andrew
authors.initials: A
authors.lastname: Coup
authors.forename: Carol
authors.initials: C
authors.lastname: Hunt
authors.forename: Laurence
authors.initials: L
authors.lastname: Coombs
mesh_terms: D000368:Aged; D001706:Biopsy; D018288:Carcinoma, Small Cell / Q000175:diagnosis*; D003937:Diagnosis, Differential; D017809:Fatal Outcome; D005500:Follow-Up Studies; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D011467:Prostate / Q000473:pathology*; D011471:Prostatic Neoplasms / Q000175:diagnosis*