title: Steps toward a globally available malaria vaccine: harnessing the potential of algae for future low cost vaccines.
abstract: Malaria is an infectious disease that threatens half of the world's population. This debilitating disease is caused by infection from parasites of the genus Plasmodium. Insecticides, bed nets and drug therapies have lowered the prevalence and death rate associated with malaria but this disease continues to plague many populations around the world. In recent years, many organizations have suggested developing methods for a complete eradication of malaria. The most straightforward and effective method for this potential eradication will be through the development of a low-cost vaccine. To achieve eradication, it will be necessary to develop new vaccine candidates and novel systems for both the production and delivery of these vaccines. Recently, the green algae Chlamydomonas reinhardtii has been used for the recombinant expression of malaria vaccine candidates including the transmission blocking vaccine candidate Pfs48/45. Here, we discuss the potential of this research on the future development of a low-cost malaria vaccine candidate.
authors.affiliation: The San Diego Center for Algae Biotechnology and the Division of Biological Sciences, University of California, San Diego, La Jolla, CA, USA.
authors.forename: Carla S
authors.initials: CS
authors.lastname: Jones
authors.forename: Stephen P
authors.initials: SP
authors.lastname: Mayfield
mesh_terms: D000953:Antigens, Protozoan / Q000235:genetics / Q000378:metabolism; D016825:Chlamydomonas reinhardtii / Q000235:genetics* / Q000378:metabolism; D015870:Gene Expression; D006801:Humans; D008288:Malaria / Q000469:parasitology / Q000517:prevention & control*; D017780:Malaria Vaccines / Q000235:genetics* / Q000378:metabolism*; D010963:Plasmodium falciparum / Q000235:genetics / Q000276:immunology / Q000502:physiology
chemical_list: D000953:Antigens, Protozoan; D017780:Malaria Vaccines
keywords: Chlamydomonas reinhardtii; Pfs48/45; Plasmodium falciparum; algae; chloroplast engineering; malaria; protein expression; transmission blocking vaccine