title: Two-year follow-up study on neurodevelopmental outcomes after term intrapartum asphyxia using age and stages questionnaire.
abstract: Birth asphyxia is one of the multiple causes of neonatal encephalopathy. The objective of this study was to evaluate neurodevelopmental outcomes of newborn term infants with definitive asphyxia. Thirty infants met study criteria for asphyxia. The 5-year incidence of asphyxia was estimated to be 5.5 in 1000. According to the Age and Stage Questionnaire, 10.5% of 6-month-old infants, 14.3% of 12- and 18-month-old infants, and 5.3% of 24-month-old infants had neurodevelopmental delay in gross motor function in the absence of cerebral palsy. In 7.3% of 18-month-old infants, neurodevelopmental delay in problem-solving ability was observed. Higher values of Apgar score and bicarbonate levels were associated with higher Age and Stage Questionnaire total score. Delivery type, maternal age, gravidity of mother, and existence of mother disease during pregnancy were also associated with lower Age and Stage Questionnaire total score in different stages of life.
authors.affiliation: 1Department of Pediatrics, Imam Hospital, Tehran University of Medical Sciences, Tehran, Iran.
authors.forename: Zarrin
authors.initials: Z
authors.lastname: Keihani-Doust
authors.forename: Maryam
authors.initials: M
authors.lastname: Saeedi
authors.forename: Tahere
authors.initials: T
authors.lastname: Esmaeilni
authors.forename: Massoud
authors.initials: M
authors.lastname: Habibi
authors.forename: Seyed Saeed Hashemi
authors.initials: SS
authors.lastname: Nazari
mesh_terms: D000367:Age Factors; D001034:Apgar Score; D001238:Asphyxia Neonatorum / Q000150:complications* / Q000453:epidemiology; D001930:Brain Injuries / Q000175:diagnosis* / Q000209:etiology*; D002675:Child, Preschool; D002658:Developmental Disabilities / Q000175:diagnosis* / Q000209:etiology*; D005260:Female; D006801:Humans; D007223:Infant; D008137:Longitudinal Studies; D008297:Male; D011237:Predictive Value of Tests; D011795:Surveys and Questionnaires
keywords: Age and Stage Questionnaire; Apgar; asphyxia; encephalopathy; neurodevelopmental delay; term infant