title: Complete genome sequence of a novel bovine norovirus: evidence for slow genetic evolution in genogroup III genotype 2 noroviruses.
abstract: A new genogroup III genotype 2 bovine norovirus, B309/2003/BE, was entirely sequenced and genetically compared to the original Newbury2/1976/UK strain and to Dumfries/1994/UK, detected in 1976 and 1994, respectively. Interestingly, except in well-defined coding regions (N-terminal protein, 3A-like protease, hypervariable region of the capsid protein, and C-terminal part of the minor structural protein), very low genetic differences were noted between the entire genomes of these three strains along a 30-year-long period. It allowed some hypotheses of hotspots of genetic evolution through a low genetic evolution background in genotype 2 genogroup III bovine noroviruses.
authors.affiliation: Department of Infectious and Parasitic Diseases, Veterinary Virology and Animal Viral Diseases, Faculty of Veterinary Medicine, University of Liège, Liège, Belgium.
authors.forename: A
authors.initials: A
authors.lastname: Mauroy
authors.forename: A
authors.initials: A
authors.lastname: Scipioni
authors.forename: E
authors.initials: E
authors.lastname: Mathijs
authors.forename: D
authors.initials: D
authors.lastname: Ziant
authors.forename: G
authors.initials: G
authors.lastname: Daube
authors.forename: E
authors.initials: E
authors.lastname: Thiry
mesh_terms: D000818:Animals; D002417:Cattle; D004279:DNA, Viral; D030541:Databases, Genetic; D019143:Evolution, Molecular; D005814:Genes, Viral; D016679:Genome, Viral; D005838:Genotype; D008969:Molecular Sequence Data; D029322:Norovirus / Q000235:genetics*; D016366:Open Reading Frames; D017422:Sequence Analysis, DNA
chemical_list: D004279:DNA, Viral