title: Cardiospheres and cardiosphere-derived cells as therapeutic agents following myocardial infarction.
abstract: Heart disease is a major cause of morbidity and mortality. Cellular therapies hold significant promise for patients with heart disease. Heart-derived progenitor cells are capable of repairing a diseased heart through modulation of growth factor milieu and temporary engraftment leading to endogenous repair. The proof-of-concept CADUCEUS clinical trial using cardiosphere-derived cells has shown evidence of therapeutic cardiac tissue regeneration. Future clinical trials are now being planned to generate additional safety and efficacy data in the hopes of building toward an approved cellular therapy for heart disease.
authors.affiliation: Capricor, Inc., Los Angeles, CA 90048, USA. mkreke@capricor.com
authors.forename: Michelle
authors.initials: M
authors.lastname: Kreke
authors.forename: Rachel Ruckdeschel
authors.initials: RR
authors.lastname: Smith
authors.forename: Linda
authors.initials: L
authors.lastname: Marbán
authors.forename: Eduardo
authors.initials: E
authors.lastname: Marbán
mesh_terms: D053687:Adult Stem Cells / Q000187:drug effects* / Q000637:transplantation*; D000418:Albumins / Q000008:administration & dosage / Q000009:adverse effects / Q000494:pharmacology / Q000627:therapeutic use*; D000818:Animals; D062906:Cardiac Catheters; D006321:Heart / Q000187:drug effects / Q000502:physiology; D006801:Humans; D007261:Infusions, Intra-Arterial; D007273:Injections, Intramuscular; D009203:Myocardial Infarction / Q000188:drug therapy / Q000473:pathology / Q000628:therapy*; D009206:Myocardium / Q000166:cytology; D011091:Polyesters / Q000008:administration & dosage / Q000009:adverse effects / Q000494:pharmacology / Q000627:therapeutic use*; D012038:Regeneration; D033581:Stem Cell Transplantation / Q000009:adverse effects / Q000379:methods
chemical_list: D000418:Albumins; C522044:PB-127 compound; D011091:Polyesters