title: A Copper-Catalyzed Arylation of Tryptamines for the Direct Synthesis of Aryl Pyrroloindolines.
abstract: An operationally simple, copper-catalyzed arylation of N-tosyltryptamines provides direct access to C3-aryl pyrroloindolines. A range of electron-donating and electron-withdrawing substituents is tolerated on both the indole backbone and the aryl electrophile. These reactions occur under ambient temperatures and with equimolar quantities of the coupling partners.
authors.affiliation: The Warren and Katharine Schlinger Laboratory of Chemistry and Chemical Engineering, Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, CA 91125 (USA).
authors.forename: Madeleine E
authors.initials: ME
authors.lastname: Kieffer
authors.forename: Kangway V
authors.initials: KV
authors.lastname: Chuang
authors.forename: Sarah E
authors.initials: SE
authors.lastname: Reisman