title: Association between IL10, IL10RA, and IL10RB SNPs and ischemic stroke with hypertension in Korean population.
abstract: The pathogenesis of stroke is associated with the immune and inflammatory responses. Cytokines, such as interleukin 10 (IL10), play an important role in the process of inflammation. To investigate whether IL10, IL10RA, and IL10RB polymorphisms are associated with the risk of ischemic stroke (IS), selected two IL10 SNPs (rs1518111 and rs1554286), three IL10RA SNPs (rs2256111, rs4252243, and rs2228054), and two IL10RB SNPs (rs999788 and rs2834167) were analyzed in 120 patients with IS and 285 control subjects. All IS patients were classified into the clinical subgroups, according to the levels of blood pressure (hypertension, present and absent), fasting plasma glucose (diabetes mellitus, present and absent), and lipids (dyslipidemia, present and absent). SNPStats and SPSS 18.0 program were used to obtain the odds ratios, 95 % confidence intervals, and P values. Multiple logistic regression models (codominant1, codominant2, dominant, recessive, and log-additive models) were performed to analyze the genetic data. Seven polymorphisms were not associated with the IS, but showed significant associations with hypertension, in the risk of IS. These results suggest that the IL10, IL10RA, and IL10RB genes may be contributed to the hypertension in the risk of IS in the Korean population.
authors.affiliation: Departments of Emergency Medicine, School of Medicine, Kyung Hee University, Seoul, 130-701, Republic of Korea.
authors.forename: Hyun-Kyung
authors.initials: HK
authors.lastname: Park
authors.forename: Dong Hwan
authors.initials: DH
authors.lastname: Kim
authors.forename: Dong Hwan
authors.initials: DH
authors.lastname: Yun
authors.forename: Ju Yeon
authors.initials: JY
authors.lastname: Ban
mesh_terms: D000368:Aged; D002545:Brain Ischemia / Q000235:genetics*; D016022:Case-Control Studies; D005260:Female; D005787:Gene Frequency; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D006973:Hypertension / Q000150:complications / Q000235:genetics*; D016753:Interleukin-10 / Q000235:genetics*; D053709:Interleukin-10 Receptor alpha Subunit / Q000235:genetics*; D053710:Interleukin-10 Receptor beta Subunit / Q000235:genetics*; D015810:Linkage Disequilibrium; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D056910:Republic of Korea; D017422:Sequence Analysis, DNA
chemical_list: C508609:IL10 protein, human; C081846:IL10RB protein, human; D053709:Interleukin-10 Receptor alpha Subunit; D053710:Interleukin-10 Receptor beta Subunit; D016753:Interleukin-10