title: [Group A streptococcal meningitis].
abstract: An increased incidence and severity of invasive group A streptococcus (GAS) infections over the past decade have been reported by several authors, but GAS remains an uncommon cause of bacterial meningitis. The aim of this study was to describe and analyze the clinical and biological data of GAS meningitis by reporting 10 new cases of pediatric GAS meningitis and making a literature review. The mean age of patients, seven girls and three boys, was 3 years. There was a history of preexisting or concomitant community-acquired infection in five patients over 10. The outcome was fatal in two cases. All patients received an initial empirical antimicrobial therapy with a third generation cephalosporin switched in six cases to amoxicillin. The prognosis for this type of streptococcal meningitis is usually good, but death may occur even in children without any identified risk factor for severe infection.
authors.affiliation: Service de Maladies Infectieuses Pédiatriques, Hôpital d'Enfants, Casablanca, Maroc.
authors.forename: Z
authors.initials: Z
authors.lastname: Jouhadi
authors.forename: H
authors.initials: H
authors.lastname: Sadiki
authors.forename: M
authors.initials: M
authors.lastname: Lehlimi
authors.forename: Z
authors.initials: Z
authors.lastname: Honsali
authors.forename: J
authors.initials: J
authors.lastname: Najib
authors.forename: K
authors.initials: K
authors.lastname: Zerouali
authors.forename: H
authors.initials: H
authors.lastname: Belabess
authors.forename: N
authors.initials: N
authors.lastname: Mdaghri
mesh_terms: D000658:Amoxicillin / Q000627:therapeutic use; D000667:Ampicillin / Q000627:therapeutic use; D002511:Cephalosporins / Q000627:therapeutic use; D002675:Child, Preschool; D017714:Community-Acquired Infections / Q000453:epidemiology / Q000382:microbiology; D003428:Cross Infection / Q000453:epidemiology / Q000382:microbiology; D005260:Female; D006785:Hospitals, University / Q000706:statistics & numerical data; D006801:Humans; D015994:Incidence; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D016920:Meningitis, Bacterial / Q000188:drug therapy / Q000453:epidemiology* / Q000382:microbiology / Q000401:mortality; D009018:Morocco / Q000453:epidemiology; D011183:Postoperative Complications / Q000453:epidemiology / Q000382:microbiology; D013290:Streptococcal Infections / Q000188:drug therapy / Q000453:epidemiology* / Q000382:microbiology / Q000401:mortality; D013297:Streptococcus pyogenes / Q000302:isolation & purification*
chemical_list: D002511:Cephalosporins; D000667:Ampicillin; D000658:Amoxicillin