title: [Incidence of catheter-related infection and associated risk factors in hospitalized patients with parenteral nutrition].
abstract: BACKGROUND
  The most severe complication of parenteral nutrition (PTN) is catheter-related infection (CRI).
  
  
  OBJECTIVE
  To study the incidence rate and factors associated to CRI.
  
  
  METHODS
  271 patients followed at the Nutrition Unit for 6 months. The composition of the PTN was calculated according to the metabolic demands. 20.3% received a lipid solution enriched with omega-3 fatty acids (SMOF Fresenius Kabi®) and 79.7% with olive oil (Clinoleic Baxter®).
  
  
  RESULTS
  The rate of CRI was 25 per 1,000 days of PTN (55 patients: 61.7±17.8 years, 60.3% males, 29.3±10.6 days of hospital stay and 10.4% mortality). Coagulase-negative Staphylococcus was the most frequently isolated microorganism. There were no differences by age, gender, mortality, or composition of the PTN between patients with or without infection. The patients treated with omega-3 received more calories with the PTN, at the expense of higher intake of glucose and lipids. However, the rate of infection was similar, although there was a not significant trend towards a lower infection rate when using the omega-3 composition (14.5% vs. 23.1%, respectively, p = 0.112). The duration of the nutritional support was higher in patients with CRI (13.0 ± 9.7 vs. 9.3 ± 8.1, p = 0.038). Total mortality (16.9%) was independent of the presence or absence of CRI (10.4% vs. 18.7%, p = 0.090) or of the use of omega-3 lipids or olive oil in the PTN (10.9% vs. 18.5%, p = 0.125).
  
  
  CONCLUSIONS
  Patients submitted to PTN have a high rate of CRI. The presence of infection is related to the duration of the PTN, being independent of the age, gender, and composition of the solution. The use of omega-3 lipid solutions may be beneficial although further studies are needed to confirm this.
authors.affiliation: Servicio de Farmacia, Hospital 12 de Octubre, Madrid, España.
authors.forename: Ma J
authors.initials: MJ
authors.lastname: Aguilella Vizcaíno
authors.forename: Ma Á
authors.initials: MÁ
authors.lastname: Valero Zanuy
authors.forename: C
authors.initials: C
authors.lastname: Gastalver Martín
authors.forename: P
authors.initials: P
authors.lastname: Gomis Muñoz
authors.forename: J M
authors.initials: JM
authors.lastname: Moreno Villares
authors.forename: M
authors.initials: M
authors.lastname: León Sanz
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D055499:Catheter-Related Infections / Q000453:epidemiology* / Q000401:mortality; D015525:Fatty Acids, Omega-3 / Q000008:administration & dosage; D005260:Female; D005526:Food, Formulated; D017052:Hospital Mortality; D006760:Hospitalization; D006801:Humans; D007297:Inpatients; D008297:Male; D008875:Middle Aged; D018529:Nutritional Support; D000069463:Olive Oil; D010288:Parenteral Nutrition / Q000009:adverse effects*; D010938:Plant Oils; D012307:Risk Factors; D013030:Spain / Q000453:epidemiology; D013203:Staphylococcal Infections / Q000453:epidemiology / Q000209:etiology
chemical_list: D015525:Fatty Acids, Omega-3; D000069463:Olive Oil; D010938:Plant Oils