title: Cell-based therapies for epidermolysis bullosa - from bench to bedside.
abstract: Significant progress has been made over the past two decades in molecular genetics of epidermolysis bullosa (EB), a group of heritable blistering disorders, with diagnostic and prognostic implications. More recently, novel molecular approaches have been developed towards potential treatment of EB, with emphasis on gene-, protein-, and cell-based strategies. This overview highlights cell-based approaches that have recently been tested in pilot clinical trials, attesting to the potential of regenerative medicine for blistering skin diseases.
authors.affiliation: Department of Dermatology and Cutaneous Biology, Jefferson Medical College, Philadelphia, Pennsylvania 19107, USA. jouni.uitto@jefferson.edu
authors.forename: Jouni
authors.initials: J
authors.lastname: Uitto
authors.forename: Cristina
authors.initials: C
authors.lastname: Has
authors.forename: Leena
authors.initials: L
authors.lastname: Bruckner-Tuderman
mesh_terms: D016026:Bone Marrow Transplantation / Q000639:trends*; D004820:Epidermolysis Bullosa / Q000175:diagnosis* / Q000601:surgery*; D006801:Humans; D033581:Stem Cell Transplantation / Q000639:trends*; D057170:Translational Research, Biomedical / Q000639:trends*