title: DNA as a chiral scaffold for asymmetric synthesis.
abstract: The application of DNA-based hybrid catalysts for enantioselective synthesis has recently emerged. These catalysts, self-assembled from DNA and a metal complex with a specific ligand through supramolecular or covalent anchoring strategies, have demonstrated high enantioselectivity in a variety of carbon-carbon or carbon-heteroatom bond-forming reactions and have expanded their role in asymmetric catalysis. In this review, we summarize the advent and significant progress of DNA-based asymmetric catalysis and discuss remaining challenges in using DNA as a chiral scaffold. We hope that this review will inspire many of today’s active scientists in asymmetric catalysis.
authors.affiliation: Department of Chemistry, Graduate School of Science, Kyoto University, Kitashirakawa-oiwakecho, Sakyo-ku, Kyoto 606-8502, Japan.
authors.forename: Soyoung
authors.initials: S
authors.lastname: Park
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Sugiyama
mesh_terms: D000478:Alkylation; D000586:Amination; D002384:Catalysis; D056831:Coordination Complexes / Q000737:chemistry; D061565:Cycloaddition Reaction; D004247:DNA / Q000737:chemistry*; D006801:Humans; D009690:Nucleic Acid Conformation; D013237:Stereoisomerism
chemical_list: D056831:Coordination Complexes; D004247:DNA