title: Effect of obesity and insulin resistance on diabetic control.
abstract: Diabetes Mellitus in obese and non-obese Indian individuals.
  
  
  OBJECTIVE
  Effect of Obesity and insulin resistance on diabetic control.
  
  
  METHODS
  50 each groups Diabetic individuals obese and non-obese.
  
  
  METHODS
  On selected 50 each group diabetic patient and normal, following blood investigations has been performed-Plasma Glucose, Glycohemoglobin and Serum Insulin.
  
  
  METHODS
  Individuals patient's results were analyzed and compared with the normal controls.
  
  
  CONCLUSIONS
  The changes in glycosylated haemoglobin are mainly proportional to the post lunch glucose level (r=0.773) (p<0.01) and not correlated to circulating insulin or the body mass index. However the levels were higher in obese diabetes (Type I and II both) than in non-obese. Mechanism of resistance in insulin receptor interactions due to obesity is well known. However, obesity does not seem to affect directly glycosylated haemoglobin. Under such circumstances, the reduction of weight for a diabetic person can improve sugar control by minimizing insulin resistance and thereby can improve glycosylated haemoglobin levels.
authors.affiliation: Department of Biochemistry, The Institute of Science, 15 Madame Cama Road, 400 032 Mumbai.
authors.forename: Kumud
authors.initials: K
authors.lastname: Kale
authors.forename: D K
authors.initials: DK
authors.lastname: Rawat
keywords: Diabetes Mellitus; Obesity and insulin resistance; glycosylated haemoglobin; plasma glucose