title: 2'-F-ANA-guanosine and 2'-F-guanosine as powerful tools for structural manipulation of G-quadruplexes.
abstract: Here we demonstrate the applicability of 2'-F-ANA-guanosine and 2'-F-guanosine as powerful tools for manipulating G-quadruplex folding by anti-position-favoring substitutions. A single guanine to 2'-F-ANA-guanine substitution can favor a single (3+1) hybrid conformation from a mixture of conformers. Rational substitutions of either type of 2'-F-modified nucleotide enable conformational switching from a (3+1) hybrid to a parallel folding topology.
authors.affiliation: School of Physical and Mathematical Sciences, Nanyang Technological University, Singapore.
authors.forename: Christopher Jacques
authors.initials: CJ
authors.lastname: Lech
authors.forename: Zhe
authors.initials: Z
authors.lastname: Li
authors.forename: Brahim
authors.initials: B
authors.lastname: Heddi
authors.forename: Anh Tuân
authors.initials: AT
authors.lastname: Phan
mesh_terms: D001483:Base Sequence; D003849:Deoxyguanosine / Q000031:analogs & derivatives* / Q000737:chemistry / Q000235:genetics; D054856:G-Quadruplexes; D006151:Guanosine / Q000031:analogs & derivatives / Q000737:chemistry* / Q000235:genetics; D006801:Humans
chemical_list: C582556:2'-F-ANA-guanosine; D006151:Guanosine; C083670:2'-deoxy-2'-fluoroguanosine; D003849:Deoxyguanosine