title: Dietary polyphenols preconditioning protects 3T3-L1 preadipocytes from mitochondrial alterations induced by oxidative stress.
abstract: Numerous studies indicate that an increase in reactive oxygen species (ROS) significantly affects white adipose tissue biology and leads to an inflammatory profile and insulin resistance, which could contribute to obesity-associated diabetes and cardiovascular diseases. Mitochondria play a key role in adipose tissue energy metabolism and constitute the main source of cellular ROS such as H(2)O(2). Polyphenols constitute the most abundant antioxidants provided by the human diet. Indeed, they are widely distributed in fruits, vegetables and some plant-derived beverages such as coffee and tea. Thus, the biological effects of dietary polyphenols that may increase the antioxidant capacity of the body against obesity-induced oxidative stress are of high interest. Here, we studied the capacity of polyphenols to modulate the impact of oxidative stress on the mitochondria of preadipocytes, which are important cells governing the adipose tissue development for energy homeostasis. Whereas H(2)O(2) treatment induces a proliferation arrest associated with an increase in mitochondrial content in 3T3-L1 preadipocytes, preconditioning with some major dietary polyphenols totally or partially protects the cells against oxidative stress consequences. This article is part of a Directed Issue entitled: Bioenergetic dysfunction, adaptation and therapy.
authors.affiliation: Groupe d'Etude sur l'Inflammation Chronique et l'Obésité (EA 4516), Université de La Réunion, 15 Avenue René Cassin, BP 7151, 97715 Saint-Denis Messag Cedex 9, France.
authors.forename: Pascal
authors.initials: P
authors.lastname: Baret
authors.forename: Axelle
authors.initials: A
authors.lastname: Septembre-Malaterre
authors.forename: Michel
authors.initials: M
authors.lastname: Rigoulet
authors.forename: Christian
authors.initials: C
authors.lastname: Lefebvre d'Hellencourt
authors.forename: Muriel
authors.initials: M
authors.lastname: Priault
authors.forename: Marie-Paule
authors.initials: MP
authors.lastname: Gonthier
authors.forename: Anne
authors.initials: A
authors.lastname: Devin
mesh_terms: D016475:3T3 Cells; D017667:Adipocytes / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology; D000818:Animals; D016923:Cell Death / Q000187:drug effects; D048708:Cell Growth Processes / Q000187:drug effects; D004032:Diet; D004734:Energy Metabolism / Q000187:drug effects; D006801:Humans; D007249:Inflammation / Q000378:metabolism; D007333:Insulin Resistance; D051379:Mice; D009765:Obesity / Q000378:metabolism* / Q000473:pathology; D018384:Oxidative Stress; D059808:Polyphenols / Q000494:pharmacology*
chemical_list: D059808:Polyphenols