title: Standardization of analysis sets for reporting results from ADNI MRI data.
abstract: The Alzheimer's Disease Neuroimaging Initiative (ADNI) three-dimensional T1-weighted magnetic resonance imaging (MRI) acquisitions provide a rich data set for developing and testing analysis techniques for extracting structural endpoints. To promote greater rigor in analysis and meaningful comparison of different algorithms, the ADNI MRI Core has created standardized analysis sets of data comprising scans that met minimum quality control requirements. We encourage researchers to test and report their techniques against these data. Standard analysis sets of volumetric scans from ADNI-1 have been created, comprising screening visits, 1-year completers (subjects who all have screening, 6- and 12-month scans), 2-year annual completers (screening, 1-year and 2-year scans), 2-year completers (screening, 6-months, 1-year, 18-months [mild cognitive impaired (MCI) only], and 2-year scans), and complete visits (screening, 6-month, 1-year, 18-month [MCI only], 2-year, and 3-year [normal and MCI only] scans). As the ADNI-GO/ADNI-2 data become available, updated standard analysis sets will be posted regularly.
authors.affiliation: Pfizer Inc., Groton, CT, USA. brad.wyman@pfizer.com
authors.forename: Bradley T
authors.initials: BT
authors.lastname: Wyman
authors.forename: Danielle J
authors.initials: DJ
authors.lastname: Harvey
authors.forename: Karen
authors.initials: K
authors.lastname: Crawford
authors.forename: Matt A
authors.initials: MA
authors.lastname: Bernstein
authors.forename: Owen
authors.initials: O
authors.lastname: Carmichael
authors.forename: Patricia E
authors.initials: PE
authors.lastname: Cole
authors.forename: Paul K
authors.initials: PK
authors.lastname: Crane
authors.forename: Charles
authors.initials: C
authors.lastname: DeCarli
authors.forename: Nick C
authors.initials: NC
authors.lastname: Fox
authors.forename: Jeffrey L
authors.initials: JL
authors.lastname: Gunter
authors.forename: Derek
authors.initials: D
authors.lastname: Hill
authors.forename: Ronald J
authors.initials: RJ
authors.lastname: Killiany
authors.forename: Chahin
authors.initials: C
authors.lastname: Pachai
authors.forename: Adam J
authors.initials: AJ
authors.lastname: Schwarz
authors.forename: Norbert
authors.initials: N
authors.lastname: Schuff
authors.forename: Matthew L
authors.initials: ML
authors.lastname: Senjem
authors.forename: Joyce
authors.initials: J
authors.lastname: Suhy
authors.forename: Paul M
authors.initials: PM
authors.lastname: Thompson
authors.forename: Michael
authors.initials: M
authors.lastname: Weiner
authors.forename: Clifford R
authors.initials: CR
authors.lastname: Jack
mesh_terms: D000368:Aged; D000465:Algorithms; D000544:Alzheimer Disease / Q000473:pathology*; D060825:Cognitive Dysfunction / Q000473:pathology*; D016208:Databases, Factual / Q000592:standards*; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods / Q000592:standards*; D012015:Reference Standards; D015203:Reproducibility of Results