title: The prognostic value of fine-needle  aspiration biopsy of the thyroid gland  - analysis of results of 1078 patients.
abstract: OBJECTIVE
  We aimed to evaluate the prognostic value of thyroid fine needle aspiration biopsy (FNAB) in the diagnosis of pathologic lesions.
  
  
  METHODS
  Data from 1 078 consecutive patients (female : male ratio, 9:1) who underwent thyroidectomy were retrospectively analyzed. All patients had preoperative thyroid FNAB. Unilateral and bilateral FNAB were performed in 872 and 206 patients, respectively, resulting in 1 284 cytologic aspirates, which were compared to postoperative histology. Risk factors for malignancy (age, sex, single nodule, or nodule in multinodular goiter) were evaluated.
  
  
  RESULTS
  203 (15.81%) aspirates were non-diagnostic. 768 (59.81%) were benign; 112 (8.72%) were atypical; 170 (13.24%) were follicular neoplasms, 5 (0.4%) had suspicion of malignancy; and 26 (2.02%) were malignant tumors on FNAB. The calculated risk of malignancy in each group was: 1.97%, 1.84%, 7.15%, 12.35%, 60%, and 100%. There were 2.02% false negative and 0.15% false positive results. Diagnostic discrepancies occurred in the follicular neoplasm group, of 86 biopsies (0.15%).
  
  
  CONCLUSIONS
  FNAB is the primary method of preoperative diagnostics of thyroid tumors, as it allows many patients to avoid thyroidectomy. In addition, it helps the operating surgeon to decide the extent of surgical resection.
authors.affiliation: Department of General, Gastroenterological and Endocrine Surgery, Medical University Wrocław, 50-369 Wrocław, Poland. beatawojtczak@wp.pl
authors.forename: Beata
authors.initials: B
authors.lastname: Wojtczak
authors.forename: Krzysztof
authors.initials: K
authors.lastname: Sutkowski
authors.forename: Marek
authors.initials: M
authors.lastname: Bolanowski
authors.forename: Tadeusz
authors.initials: T
authors.lastname: Łukieńczuk
authors.forename: Artur
authors.initials: A
authors.lastname: Lipiński
authors.forename: Krzysztof
authors.initials: K
authors.lastname: Kaliszewski
authors.forename: Mateusz
authors.initials: M
authors.lastname: Głód
authors.forename: Paweł
authors.initials: P
authors.lastname: Domosławski
mesh_terms: D018263:Adenocarcinoma, Follicular / Q000453:epidemiology / Q000473:pathology; D000328:Adult; D000368:Aged; D044963:Biopsy, Fine-Needle / Q000706:statistics & numerical data*; D018276:Carcinoma, Medullary / Q000453:epidemiology / Q000473:pathology; D002291:Carcinoma, Papillary / Q000453:epidemiology / Q000473:pathology*; D002294:Carcinoma, Squamous Cell / Q000453:epidemiology / Q000473:pathology; D005260:Female; D006801:Humans; D008228:Lymphoma, Non-Hodgkin / Q000453:epidemiology / Q000473:pathology; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D011379:Prognosis; D012189:Retrospective Studies; D012307:Risk Factors; D013961:Thyroid Gland / Q000473:pathology* / Q000601:surgery; D013964:Thyroid Neoplasms / Q000453:epidemiology / Q000473:pathology*; D016606:Thyroid Nodule / Q000453:epidemiology / Q000473:pathology*; D013965:Thyroidectomy; D055815:Young Adult