title: The immune microenvironment of human tumors: general significance and clinical impact.
abstract: Human cancers grow in a microenvironment of stromal, inflammatory and immunocompetent cells which is variable from tumor to tumor. The characterization of the immune contexture, i.e. the type, density and functional orientation of immunocompetent cells, the presence or absence of tertiary lymphoid structures is a major prognostic factor for patients survival and represent a guide and a target for innovative cancer therapies.
authors.affiliation: Institut National de la Santé et de la Recherche Médicale (INSERM), U872, Centre de Recherche des Cordeliers, 15 rue de l'Ecole de Médecine, 75006, Paris, France, herve.fridman@crc.jussieu.fr.
authors.forename: Wolf-Herman
authors.initials: WH
authors.lastname: Fridman
authors.forename: Marie-Caroline
authors.initials: MC
authors.lastname: Dieu-Nosjean
authors.forename: Franck
authors.initials: F
authors.lastname: Pagès
authors.forename: Isabelle
authors.initials: I
authors.lastname: Cremer
authors.forename: Diane
authors.initials: D
authors.lastname: Damotte
authors.forename: Catherine
authors.initials: C
authors.lastname: Sautès-Fridman
authors.forename: Jérôme
authors.initials: J
authors.lastname: Galon