title: A rapid microfluidic synthesis of [18F]fluoroarenes from nitroarenes.
abstract: Microfluidic radiofluorodenitrations have been successfully performed using a commercially available microfluidic synthesis system. Reactions of nitroarenes with para-substituted electron withdrawing groups provide incorporation yields ranging from 43 to 97%. Ortho- and meta-substituted nitroarenes provided incorporation yields up to 35%. The reactions were conducted using dry, no-carrier-added [(18)F]-fluoride and K(2)CO(3)/K(222) dissolved in N,N-dimethylformamide or dimethyl sulfoxide with total synthesis times of less than five min. The methodology developed in these studies can be applied to the synthesis of a variety of fluorine-18 labeled radiotracers and radiolabeled prosthetic groups from nitroarene precursors.
authors.affiliation: Departments of Chemistry and Radiology, University of Tennessee, Knoxville, 37996-1600, USA.
authors.forename: Thomas M
authors.initials: TM
authors.lastname: Moore
authors.forename: Murthy R
authors.initials: MR
authors.lastname: Akula
authors.forename: Lee
authors.initials: L
authors.lastname: Collier
authors.forename: George W
authors.initials: GW
authors.lastname: Kabalka