title: Targeting FOXM1 in cancer.
abstract: Oncogenic transcription factor FOXM1 is overexpressed in the majority of human cancers. In addition, FOXM1 has been implicated in cell migration, invasion, angiogenesis and metastasis. The important role of FOXM1 in cancer affirms its significance for therapeutic intervention. Current data suggest that targeting FOXM1 in mono- or combination therapy may have promising therapeutic benefits for the treatment of cancer. However, challenges with the delivery of anti-FOXM1 siRNA to tumors and the absence of small molecules, which specifically inhibit FOXM1, are delaying the development of FOXM1 inhibitors as feasible anticancer drugs. In this review, we describe and summarize the efforts that have been made to target FOXM1 in cancer and the consequences of FOXM1 suppression in human cancer cells.
authors.affiliation: Department of Medicine, University of Illinois at Chicago, Chicago, IL, United States of America.
authors.forename: Marianna
authors.initials: M
authors.lastname: Halasi
authors.affiliation: Department of Medicine, University of Illinois at Chicago, Chicago, IL, United States of America. Electronic address: agartel@uic.edu.
authors.forename: Andrei L
authors.initials: AL
authors.lastname: Gartel
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry / Q000145:classification / Q000627:therapeutic use*; D015195:Drug Design; D000072278:Forkhead Box Protein M1; D051858:Forkhead Transcription Factors / Q000037:antagonists & inhibitors* / Q000235:genetics / Q000378:metabolism*; D015972:Gene Expression Regulation, Neoplastic / Q000502:physiology*; D006801:Humans; D009369:Neoplasms / Q000378:metabolism / Q000628:therapy*; D034622:RNA Interference
chemical_list: D000970:Antineoplastic Agents; C107585:FOXM1 protein, human; D000072278:Forkhead Box Protein M1; D051858:Forkhead Transcription Factors