title: From sirtuin biology to human diseases: an update.
abstract: Originally rising to notoriety for their role in the regulation of aging, sirtuins are a family of NAD(+)-dependent enzymes that have been connected to a steadily growing set of biological processes. In addition to regulating aging, sirtuins play key roles in the maintenance of organismal metabolic homeostasis. These enzymes also have primarily protective functions in the development of many age-related diseases, including cancer, neurodegeneration, and cardiovascular disease. In this minireview, we provide an update on the known roles for each of the seven mammalian sirtuins in these areas.
authors.affiliation: Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, Massachusetts 02114, USA.
authors.forename: Carlos
authors.initials: C
authors.lastname: Sebastián
authors.forename: F Kyle
authors.initials: FK
authors.lastname: Satterstrom
authors.forename: Marcia C
authors.initials: MC
authors.lastname: Haigis
authors.forename: Raul
authors.initials: R
authors.lastname: Mostoslavsky
mesh_terms: D000375:Aging / Q000378:metabolism; D001921:Brain / Q000378:metabolism; D004194:Disease; D006801:Humans; D008660:Metabolism; D037761:Sirtuins / Q000378:metabolism*
chemical_list: D037761:Sirtuins