title: [Zinc signaling : a novel regulatory system on bone homeostasis, and immune and allergic responses].
abstract: Zinc (Zn) is an essential trace element that is required for proliferation, differentiation, and variety of cellular functions, and unbalanced homeostasis of Zn ion (Zn(2 + )) results in health problems such as abnormal bone formation and immunodeficiency. Recent studies have shed light on important roles of Zn(2 + )as a signaling mediator, called Zn signal. Zn(2 + )homeostasis is regulated through Zn transporters and cation channels. Advances of genetic and molecular approaches have revealed that Zn signal regulates mammalian physiology and pathogenesis. We will address that Zn signal undoubtedly contributes to our health, by highlighting it in bone homeostasis and immune regulation, and discuss that the "Zn signal axis" selectively controls intracellular signal transduction to fine-tune cellular functions.
authors.affiliation: Department of Allergy and Immunology, Osaka University Graduate School of Medicine, Japan.
authors.forename: Toshiyuki
authors.initials: T
authors.lastname: Fukada
authors.forename: Keigo
authors.initials: K
authors.lastname: Nishida
authors.forename: Satoru
authors.initials: S
authors.lastname: Yamasaki
authors.forename: Shintaro
authors.initials: S
authors.lastname: Hojyo
mesh_terms: D000818:Animals; D001842:Bone and Bones / Q000276:immunology* / Q000378:metabolism; D002450:Cell Communication / Q000276:immunology / Q000502:physiology; D006706:Homeostasis; D006801:Humans; D006967:Hypersensitivity / Q000276:immunology*; D015398:Signal Transduction; D015032:Zinc / Q000276:immunology*
chemical_list: D015032:Zinc