title: Transcription factor-7-like 2 gene variants are strongly associated with type 2 diabetes in Lebanese subjects.
abstract: We tested the association of TCF7L2 variants with type 2 diabetes (T2DM) in 691 Lebanese people and 919 controls. rs7901695, rs4506565, rs7903146, rs12243326, rs7895340, and rs12255372 minor allele frequencies were higher in T2DM. Haplotype analysis (rs7901695-rs4506565-rs7903146-rs12243326-rs7895340-rs11196205-rs12255372) identified positively- (2122112, 2222222) and negatively- (1111111) T2DM-associated haplotypes. TCF7L2 is a common T2DM candidate gene in Lebanese people.
authors.affiliation: Department of Endocrinology, University Medical Center Rizk Hospital, Beirut, Lebanon.
authors.forename: Rita
authors.initials: R
authors.lastname: Nemr
authors.forename: Amira
authors.initials: A
authors.lastname: Turki
authors.forename: Akram
authors.initials: A
authors.lastname: Echtay
authors.forename: Ghadeer S
authors.initials: GS
authors.lastname: Al-Zaben
authors.forename: Hoda S
authors.initials: HS
authors.lastname: Daher
authors.forename: Noha A
authors.initials: NA
authors.lastname: Irani-Hakime
authors.forename: Sose H
authors.initials: SH
authors.lastname: Keleshian
authors.forename: Wassim Y
authors.initials: WY
authors.lastname: Almawi
mesh_terms: D000328:Adult; D000368:Aged; D000483:Alleles; D018912:Arabs; D003924:Diabetes Mellitus, Type 2 / Q000235:genetics* / Q000378:metabolism; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D055106:Genome-Wide Association Study; D006239:Haplotypes; D006801:Humans; D007861:Lebanon; D015810:Linkage Disequilibrium; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D058118:Transcription Factor 7-Like 2 Protein / Q000235:genetics* / Q000378:metabolism
chemical_list: C544894:TCF7L2 protein, human; D058118:Transcription Factor 7-Like 2 Protein