title: Giant condyloma acuminatum quickly growing: case report.
abstract: BACKGROUND
  Giant Condyloma Acuminatum (GCA) is a rare, slow growing, large cauliflower tumor of the penile foreskin and perianal region with benign histologic appearance but high propensity for local invasion and recurrences. GCA is associated with Human Papilloma Virus (HPV) types 6 and 11 and it also has considerable risk of neoplastic transformation into fully invasive squamous cell carcinoma into about 5 years.
  
  
  OBJECTIVE
  Because of the rarity of perianal GCA, to date there is no general agreement on the best method for treatment. We wanted to know if surgical approach only was a good method to treat our case.
  
  
  METHODS
  A 28 years old man, HIV-negative, with a 4 years history of perianal GCA quickly growing underwent full tickness local excision at least 0,7 cm margin of normal tissue with skin grafting taken from the thighs. Fecal contamination was avoided by diet and loperamide per os. At two years follow-up no recurrence was detected.
  
  
  CONCLUSIONS
  Surgical approach with full tickness excision and immediate skin-grafting and regular follow-up demonstrated effective to treat GCA and to minimize disease recurrence.
authors.affiliation: Department of Surgery and Oncology Sciences, General Surgery Unit, University of Study of Palermo, Italy.
authors.forename: R
authors.initials: R
authors.lastname: Patti
authors.forename: P
authors.initials: P
authors.lastname: Aiello
authors.forename: G L
authors.initials: GL
authors.lastname: Angelo
authors.forename: G
authors.initials: G
authors.lastname: Di Vita
mesh_terms: D000328:Adult; D001005:Anus Neoplasms / Q000473:pathology* / Q000601:surgery; D062688:Buschke-Lowenstein Tumor / Q000473:pathology* / Q000601:surgery; D018450:Disease Progression; D006801:Humans; D008297:Male; D013997:Time Factors