title: Disseminated cryptococcosis in an HIV-positive boy.
abstract: Cryptococcosis is rare among children, only occurring in about 1% of children with HIV. We report the case of a 12-year-old boy with disseminated cryptococcosis. He had a history of recurrent pneumonia. He then developed meningeal symptoms and was found to have disseminated Cryptococcus neoformans by cerebrospinal fluid and bone marrow aspirate culture. He was treated with amphotericin B for 2 weeks (1 mg/kg/day), and then with fluconazole orally for 8 weeks (12 mg/kg/day). He also received a new diagnosis of HIV and was started on antiretroviral therapy 2 weeks after starting antifungal treatment. At follow-up 8 weeks later, he was doing well.
authors.affiliation: Department of Pediatrics, University of Minnesota, Minneapolis, Minneapolis, Minnesota, USA.
authors.forename: Deanna
authors.initials: D
authors.lastname: Friedman
authors.forename: Kritsana
authors.initials: K
authors.lastname: Kongthavonsakul
authors.forename: Peninnah
authors.initials: P
authors.lastname: Oberdorfer
mesh_terms: D017088:AIDS-Related Opportunistic Infections / Q000188:drug therapy*; D000666:Amphotericin B / Q000627:therapeutic use; D019380:Anti-HIV Agents / Q000627:therapeutic use; D000935:Antifungal Agents / Q000627:therapeutic use*; D002648:Child; D003453:Cryptococcosis / Q000188:drug therapy* / Q000382:microbiology; D003455:Cryptococcus neoformans; D015725:Fluconazole / Q000627:therapeutic use; D006678:HIV; D006679:HIV Seropositivity / Q000150:complications* / Q000188:drug therapy; D006801:Humans; D008297:Male
chemical_list: D019380:Anti-HIV Agents; D000935:Antifungal Agents; D000666:Amphotericin B; D015725:Fluconazole