title: Nanoencapsulation of quercetin and resveratrol into elastic liposomes.
abstract: Based on the fact that quercetin (QUE) and resveratrol (RES) induce a synergic inhibition of the adipogenesis and increase apoptosis in adipocytes, and that sodium deoxycholate (SDC) has necrotic effects, the nanoencapsulation of QUE and RES into SDC-elastic liposomes is proposed as a new approach for dissolving the subcutaneous fat. The concentration of constituents and the effect of the drug incorporation into cyclodextrin inclusion complexes on the stability of QUE/RES-loaded liposomes were studied. The best liposomal formulation reduced the use of phosphatidylcholine and cholesterol in 17.7% and 68.4%, respectively. Liposomes presented a mean diameter of 149nm with a polydispersion index of 0.3. The zeta potential of liposomes was slightly negative (-13.3mV) due to the presence of SDC in the phospholipid bilayer. Encapsulation efficiency of QUE and RES into liposomes was almost 97%. To summarize, QUE/RES-loaded elastic liposomes are stable and suitable for subcutaneous injection, thereby providing a new strategy for reducing subcutaneous fat.
authors.affiliation: Universidade Federal de Pernambuco (UFPE), Laboratório de Imunopatologia Keizo-Asami (LIKA), Av. Prof. Moraes Rego, 1235, Cidade Universitária, 50670-901, Recife, PE, Brazil.
authors.forename: Pabyton G
authors.initials: PG
authors.lastname: Cadena
authors.forename: Marcela A
authors.initials: MA
authors.lastname: Pereira
authors.forename: Rafaela B S
authors.initials: RB
authors.lastname: Cordeiro
authors.forename: Isabella M F
authors.initials: IM
authors.lastname: Cavalcanti
authors.forename: Benício
authors.initials: B
authors.lastname: Barros Neto
authors.forename: Maria do Carmo C B
authors.initials: Mdo C
authors.lastname: Pimentel
authors.forename: José Luiz
authors.initials: JL
authors.lastname: Lima Filho
authors.forename: Valdinete L
authors.initials: VL
authors.lastname: Silva
authors.forename: Nereide S
authors.initials: NS
authors.lastname: Santos-Magalhães
mesh_terms: D017667:Adipocytes / Q000187:drug effects; D002627:Chemistry, Physical / Q000379:methods; D002784:Cholesterol / Q000737:chemistry; D002851:Chromatography, High Pressure Liquid / Q000379:methods; D003505:Cyclodextrins / Q000737:chemistry; D003840:Deoxycholic Acid / Q000494:pharmacology; D016503:Drug Delivery Systems; D015195:Drug Design; D004548:Elasticity; D007700:Kinetics; D008081:Liposomes / Q000737:chemistry*; D008855:Microscopy, Electron, Scanning / Q000379:methods; D053758:Nanoparticles / Q000737:chemistry; D036103:Nanotechnology / Q000379:methods; D010713:Phosphatidylcholines / Q000737:chemistry; D011794:Quercetin / Q000737:chemistry*; D000077185:Resveratrol; D012995:Solubility; D013267:Stilbenes / Q000008:administration & dosage / Q000737:chemistry*; D013997:Time Factors
chemical_list: D003505:Cyclodextrins; D008081:Liposomes; D010713:Phosphatidylcholines; D013267:Stilbenes; D003840:Deoxycholic Acid; D002784:Cholesterol; D011794:Quercetin; D000077185:Resveratrol