title: [Severe pertussis: State of the art].
abstract: Pertussis is a contagious disease that has reappeared in the recent years as a public health problem in our country. The clinical presentation has changed especially in the main risk group, children under one year old, evolving in occasions to a highly lethal course called malignant or severe Pertussis. The present review discusses the epidemiology and the mechanisms of pathogenicity, and also describes the risk factors, clinical features and pathophysiology of this particular form. The current evidence and effectiveness of new treatments are described, and a treatment algorithm is proposed.
authors.affiliation: Unidad de Gestión Clínica de Niño Área de Cuidados Críticos, Hospital Padre Hurtado, Santiago, Chile.
authors.forename: Alejandro
authors.initials: A
authors.lastname: Donoso
authors.forename: Daniela
authors.initials: D
authors.lastname: Arriagada
authors.forename: Pablo
authors.initials: P
authors.lastname: Cruces
authors.forename: Franco
authors.initials: F
authors.lastname: Díaz
mesh_terms: D000465:Algorithms; D001886:Bordetella pertussis / Q000235:genetics / Q000276:immunology / Q000472:pathogenicity*; D002677:Chile / Q000453:epidemiology; D006801:Humans; D006976:Hypertension, Pulmonary / Q000209:etiology; D007937:Leukapheresis; D010567:Pertussis Vaccine / Q000627:therapeutic use; D012307:Risk Factors; D012720:Severity of Illness Index; D014917:Whooping Cough / Q000150:complications / Q000453:epidemiology / Q000503:physiopathology / Q000628:therapy
chemical_list: D010567:Pertussis Vaccine