title: Anti-neuroinflammatory constituents from Asparagus cochinchinensis.
abstract: Three new pregnane glycosides, aspacochinosides N (1), O (2), and P (3) were isolated from the roots of Asparagus cochinchinensis, together with four known furostanol glycosides. Their structures were determined by chemical methods and NMR spectral analysis, including extensive 1D and 2D NMR experiments. Compounds 1-7 were evaluated for their anti-neuroinflammatory activity in LPS-induced BV-2 microglial cells. Compounds 2, 3, and 4 showed significant inhibition on NO production in LPS-induced BV-2 microglial cells with IC(50) values of 13.51, 4.72, and 63.57μM, respectively.
authors.affiliation: State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University Health Science Center, Beijing 100191, China.
authors.forename: Rui
authors.initials: R
authors.lastname: Jian
authors.forename: Ke-Wu
authors.initials: KW
authors.lastname: Zeng
authors.forename: Jun
authors.initials: J
authors.lastname: Li
authors.forename: Ning
authors.initials: N
authors.lastname: Li
authors.forename: Yong
authors.initials: Y
authors.lastname: Jiang
authors.forename: Pengfei
authors.initials: P
authors.lastname: Tu
mesh_terms: D000818:Animals; D027761:Asparagus Plant / Q000737:chemistry*; D002460:Cell Line; D017628:Microglia / Q000187:drug effects; D015394:Molecular Structure; D018696:Neuroprotective Agents / Q000737:chemistry / Q000494:pharmacology*; D009569:Nitric Oxide / Q000378:metabolism; D018517:Plant Roots / Q000737:chemistry
chemical_list: D018696:Neuroprotective Agents; D009569:Nitric Oxide