title: Interaction of current alcohol consumption and abdominal obesity on hypertension risk.
abstract: The high prevalence of alcohol consumption and abdominal obesity and increased incidence of essential hypertension (EH) in China indicates that there may be an interaction between alcohol consumption and abdominal obesity on EH risk. Therefore, we aimed to examine the independent and combined effects of alcohol consumption and abdominal obesity on risk of EH in a Chinese cohort. We analyzed data from a population-based prospective cohort of 2778 participants aged 35-74 years from Jiangsu China who were free of hypertension, diabetes and CVD at enrollment and were followed for hypertension events. Cox proportional hazards regression model was used to calculate the hazard ratio (HR) of hypertension and corresponding 95% confidence interval (CI). Logistic regression model was used to examine the interaction between alcohol consumption and abdominal obesity on risk of hypertension. After adjusting for age, sex, smoking status, family history of hypertension, current alcohol consumption significantly increased EH risk. Compared with those without alcohol consumption, the hazard ratio of EH for participants with alcohol consumption was 1.65 (95% confidence interval 1.29-2.12). There was a statistically significant additive interaction between current alcohol consumption and abdominal obesity on EH risk. The risk of EH for current alcohol consumers with abdominal obesity was 4.49 times as high as the sum of risks in participants with a single condition alone. Both alcohol consumption and abdominal obesity are strong risk factors of EH in the Chinese population. Moreover, this study further demonstrates an additive interaction of alcohol consumption and abdominal obesity on EH risk.
authors.affiliation: Changzhou Center for Disease Control and Prevention, Changzhou, Jiangsu 213022, China; Department of Public Health, Soochow university, SuZhou, Jiangsu 215123, China.
authors.forename: Wenshu
authors.initials: W
authors.lastname: Luo
authors.forename: Zhirong
authors.initials: Z
authors.lastname: Guo
authors.forename: Chao
authors.initials: C
authors.lastname: Hao
authors.forename: Xingjuan
authors.initials: X
authors.lastname: Yao
authors.forename: Zhengyuan
authors.initials: Z
authors.lastname: Zhou
authors.forename: Ming
authors.initials: M
authors.lastname: Wu
authors.forename: Jingchao
authors.initials: J
authors.lastname: Liu
mesh_terms: D000368:Aged; D000428:Alcohol Drinking / Q000009:adverse effects*; D002681:China / Q000453:epidemiology; D000075222:Essential Hypertension; D005260:Female; D006801:Humans; D006973:Hypertension / Q000453:epidemiology / Q000209:etiology*; D008297:Male; D008875:Middle Aged; D056128:Obesity, Abdominal / Q000150:complications* / Q000453:epidemiology; D015995:Prevalence; D011446:Prospective Studies; D012306:Risk
keywords: Abdominal obesity; Alcohol; Essential hypertension; Interaction