title: SYNTHESIS AND BIOLOGICAL EVALUATION OF BIARYL ANALOGS OF ANTITUBULIN COMPOUNDS.
abstract: This paper reports the synthesis of methanones and esters bearing different substitution patterns as spacer groups between aromatic rings. This series of compounds can be considered phenstatin analogs. Two of the newly synthesized compounds, 5a and 5c, strongly inhibited tubulin polymerization and the binding of [(3)H] colchicine to tubulin, suggesting that, akin to phenstatin and combretastatin A-4, they can bind to tubulin at the colchicine site.
authors.affiliation: Centro de Ciências Exatas e Tecnologia, Universidade Federal de Mato Grosso do Sul, Av. Senador Filinto Müller, 1555, 79074-460 Campo Grande - MS, Brasil.
authors.forename: Camila Santos Suniga
authors.initials: CS
authors.lastname: Tozatti
authors.forename: Rejane Gonçalves Diniz
authors.initials: RG
authors.lastname: Khodyuk
authors.forename: Adriano Olimpio
authors.initials: AO
authors.lastname: da Silva
authors.forename: Edson Dos Anjos
authors.initials: ED
authors.lastname: Dos Santos
authors.forename: Marcos Serrou do Amaral E Dênis Pires
authors.initials: MS
authors.lastname: de Lima
authors.forename: Ernest
authors.initials: E
authors.lastname: Hamel