title: Imaging acidosis in tumors using a pH-activated near-infrared fluorescence probe.
abstract: A novel pH activatable near-infrared fluorescence probe was developed, which successfully visualized acidosis in tumors. This probe holds promise to non-invasively predict the tumor metastasis potential and evaluate the therapeutic response.
authors.affiliation: Key Laboratory of Smart Drug Delivery, Ministry of Education & PLA, School of Pharmacy, Fudan University, Shanghai, China.
authors.forename: Lu
authors.initials: L
authors.lastname: Wang
authors.forename: Xiao
authors.initials: X
authors.lastname: Zhu
authors.forename: Cheng
authors.initials: C
authors.lastname: Xie
authors.forename: Ning
authors.initials: N
authors.lastname: Ding
authors.forename: Xiaofu
authors.initials: X
authors.lastname: Weng
authors.forename: Weiyue
authors.initials: W
authors.lastname: Lu
authors.forename: Xunbin
authors.initials: X
authors.lastname: Wei
authors.forename: Cong
authors.initials: C
authors.lastname: Li
mesh_terms: D000138:Acidosis / Q000473:pathology*; D000818:Animals; D002232:Carbocyanines / Q000138:chemical synthesis / Q000737:chemistry*; D045744:Cell Line, Tumor; D005456:Fluorescent Dyes / Q000737:chemistry*; D006801:Humans; D006835:Hydrazones / Q000138:chemical synthesis / Q000737:chemistry*; D006863:Hydrogen-Ion Concentration; D007700:Kinetics; D008247:Lysosomes / Q000737:chemistry / Q000378:metabolism; D051379:Mice; D008819:Mice, Nude; D008856:Microscopy, Fluorescence; D009369:Neoplasms / Q000473:pathology; D019265:Spectroscopy, Near-Infrared; D014183:Transplantation, Heterologous
chemical_list: D002232:Carbocyanines; C579623:DiIR783-S; D005456:Fluorescent Dyes; D006835:Hydrazones