title: Saprolmycins A-E, new angucycline antibiotics active against Saprolegnia parasitica.
abstract: Saprolmycins A-E, five new anti-Saprolegnia parasitica antibiotics were isolated from the culture broth of Streptomyces sp. strain TK08046. As determined using a combination of NMR and spectroscopic analyses, the structures of these compounds were elucidated as a new group of angucycline compounds closely related to saquayamycin. Saprolmycin A and E exhibited potent anti-S. parasitica selective activities, with MIC values of 3.9 and 7.8 ng ml(-1), respectively, but weak or no activity against fungi, gram-positive or -negative bacteria, and microalgae or zooplankton. Our results suggest these two compounds as highly effective and environmentally safe anti-saprolegniasis candidates.
authors.affiliation: Graduate School of Science and Engineering, Ritsumeikan University, Kusatsu, Shiga, Japan.
authors.forename: Kazuya
authors.initials: K
authors.lastname: Nakagawa
authors.forename: Choko
authors.initials: C
authors.lastname: Hara
authors.forename: Shinji
authors.initials: S
authors.lastname: Tokuyama
authors.forename: Kentaro
authors.initials: K
authors.lastname: Takada
authors.forename: Nobutaka
authors.initials: N
authors.lastname: Imamura
mesh_terms: D000890:Anti-Infective Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D003470:Culture Media; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests; D044762:Saprolegnia / Q000187:drug effects*; D013057:Spectrum Analysis; D013302:Streptomyces / Q000378:metabolism*
chemical_list: D000890:Anti-Infective Agents; D003470:Culture Media