title: IL-17 promoted metastasis of non-small-cell lung cancer cells.
abstract: Non-small cell lung cancer (NSCLC) is the leading cause of cancer death worldwide. Recent data suggested that IL-17 might be a pivotal cytokine involved in tumor progression of NSCLC. However, the direct effect of IL-17 on metastasis of NSCLC cells still remains intractable. In this study, we found that the metastasis of NSCLC was significantly impaired in IL-17⁻/⁻ mice. Further, we revealed that IL-17 could directly promote the invasion of NSCLC cells both in vitro and in vivo. Furthermore, we found that IL-6-Stat3 pathway was crucial for IL-17 to enhance the invasive potential of NSCLC cells. Finally, we found that elevated expression of IL-17 in peripheral blood was associated with the TNM stage, and elevated expression of IL-17R in NSCLC cells was associated with their invasive potential in NSCLC patients. These findings could facilitate our understanding of the potential role of IL-17 in tumor biology, and provide clues for developing promising strategies against NSCLC.
authors.affiliation: Department of Cardiothoracic Surgery, East Hospital, Tongji University School of Medicine, Shanghai, China.
authors.forename: Qinchuan
authors.initials: Q
authors.lastname: Li
authors.forename: Yang
authors.initials: Y
authors.lastname: Han
authors.forename: Guangru
authors.initials: G
authors.lastname: Fei
authors.forename: Zhongliang
authors.initials: Z
authors.lastname: Guo
authors.forename: Tao
authors.initials: T
authors.lastname: Ren
authors.forename: Zhongmin
authors.initials: Z
authors.lastname: Liu
mesh_terms: D000818:Animals; D002289:Carcinoma, Non-Small-Cell Lung / Q000473:pathology*; D045744:Cell Line, Tumor; D049109:Cell Proliferation; D018450:Disease Progression; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D020381:Interleukin-17 / Q000097:blood / Q000235:genetics / Q000378:metabolism*; D015850:Interleukin-6 / Q000378:metabolism; D008168:Lung / Q000378:metabolism / Q000473:pathology; D008175:Lung Neoplasms / Q000473:pathology*; D051379:Mice; D008807:Mice, Inbred BALB C; D018345:Mice, Knockout; D008819:Mice, Nude; D009362:Neoplasm Metastasis; D009367:Neoplasm Staging; D053722:Receptors, Interleukin-17 / Q000096:biosynthesis / Q000378:metabolism; D050796:STAT3 Transcription Factor / Q000378:metabolism; D015398:Signal Transduction
chemical_list: D020381:Interleukin-17; D015850:Interleukin-6; D053722:Receptors, Interleukin-17; D050796:STAT3 Transcription Factor; C494087:Stat3 protein, mouse