title: Antifungal study of the resinous exudate and of meroterpenoids isolated from Psoralea glandulosa (Fabaceae).
abstract: BACKGROUND
  Psoralea glandulosa L. (Fabaceae) is a medicinal resinous shrub used in Chilean folk medicine as antiseptic in treatment of infections and skin diseases caused by bacteria and fungus.
  
  
  OBJECTIVE
  To evaluate the in vitro antifungal activity of the resin and the active components from P. glandulosa against clinical yeast isolates.
  
  
  METHODS
  Active compounds were obtained of the resinous exudate from aerial parts of P. glandulosa. Eight species of yeast were exposed to the resin and two major compounds. Minimum inhibitory concentration (MIC(80)) was determined according to the standard broth microdilution method.
  
  
  RESULTS
  Bakuchiol and 3-hydroxy-bakuchiol demonstrated potent activity with the MIC(80) ranging from 4 to >16 and 0.125 to 16 μg/mL, respectively. The resin had some degree of antifungal activity.
  
  
  CONCLUSIONS
  The overall results provided important information for the potential application of the 3-hydroxy-bakuchiol from P. glandulosa in the therapy of serious infection and skin diseases caused by clinical yeast.
authors.affiliation: Departamento de Química, Universidad Técnica Federico Santa María, Av. España No. 1680, Valparaíso, Chile. alejandro.madrid@usm.cl
authors.forename: Alejandro
authors.initials: A
authors.lastname: Madrid
authors.forename: Luis
authors.initials: L
authors.lastname: Espinoza
authors.forename: Cesar
authors.initials: C
authors.lastname: González
authors.forename: Marco
authors.initials: M
authors.lastname: Mellado
authors.forename: Joan
authors.initials: J
authors.lastname: Villena
authors.forename: Rocío
authors.initials: R
authors.lastname: Santander
authors.forename: Viviana
authors.initials: V
authors.lastname: Silva
authors.forename: Iván
authors.initials: I
authors.lastname: Montenegro
mesh_terms: D000935:Antifungal Agents / Q000494:pharmacology*; D002175:Candida / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D035261:Plant Components, Aerial; D010936:Plant Extracts / Q000494:pharmacology*; D029907:Psoralea; D012116:Resins, Plant / Q000494:pharmacology*; D013729:Terpenes / Q000494:pharmacology*
chemical_list: D000935:Antifungal Agents; D010936:Plant Extracts; D012116:Resins, Plant; D013729:Terpenes