title: Hypocholesterolemic effects of lactic acid-fermented soymilk on rats fed a high cholesterol diet.
abstract: The effect of fermented soymilk on rats fed a high cholesterol diet was investigated to clarify the cholesterol-lowering function. Male Sprague-Dawley rats aged 7 weeks were fed a control diet (1% cholesterol, high cholesterol diet), high cholesterol diet containing 11.7% fermented soymilk diet (5% soy protein as final concentration, F-5), or high cholesterol diet containing 23.4% fermented soymilk diet (10% soy protein as final concentration, F-10) for 5 weeks. The liver weight and fat mass were decreased by the ingestion of fermented soymilk. The hepatic triglyceride and cholesterol levels in the F-5 and F-10 groups were significantly lowered compared to those in the control group. The plasma total cholesterol level of the F-10 group was significantly decreased. The expression of SREBP-2, a cholesterol synthesis-related gene, was significantly decreased in liver of the F-5 group, but the expression of CYP7a1, a cholesterol catabolism-related gene, was significantly increased. These results suggest that fermented soymilk can modulate the cholesterol metabolism in rats fed a high cholesterol diet.
authors.affiliation: Department of Food Science and Nutrition, School of Human Environmental Sciences, Mukogawa Women's University, Ikebiraki-cho, Nishinomiya, Hyogo, Japan. maki1002@mukogawa-u.ac.jp
authors.forename: Maki
authors.initials: M
authors.lastname: Kobayashi
authors.forename: Rie
authors.initials: R
authors.lastname: Hirahata
authors.forename: Shintaro
authors.initials: S
authors.lastname: Egusa
authors.forename: Mitsuru
authors.initials: M
authors.lastname: Fukuda
mesh_terms: D000818:Animals; D001835:Body Weight; D002784:Cholesterol / Q000097:blood; D002791:Cholesterol, Dietary / Q000008:administration & dosage*; D059305:Diet, High-Fat; D002149:Energy Intake; D005285:Fermentation; D006937:Hypercholesterolemia / Q000517:prevention & control*; D050152:Intra-Abdominal Fat / Q000378:metabolism; D019344:Lactic Acid / Q000737:chemistry*; D050356:Lipid Metabolism; D008099:Liver / Q000378:metabolism; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D041942:Soy Milk / Q000737:chemistry*; D030262:Soybean Proteins / Q000378:metabolism; D050151:Subcutaneous Fat / Q000378:metabolism; D014057:Tomography, X-Ray Computed
chemical_list: D002791:Cholesterol, Dietary; D030262:Soybean Proteins; D019344:Lactic Acid; D002784:Cholesterol
keywords: cholesterol; fermented soymilk; lipid metabolism 