title: The triblock copolymers hydrogel through intracameral injection may be a new potential ophthalmic drug delivery with antiscarring drugs after glaucoma filtration surgery.
abstract: The hyperplasia of fiber cell at operation area cause scarring lead to the failure after glaucoma filtration surgery. People are looking for more safe and effective way to advance the success rate in operation. There are many researches demonstrated that ophthalmic drug delivery system can be a treatment. Among this, some biodegradable and thermosensitive triblock copolymers hydrogel are novel candidate for ocular drug release system. But whether they can be used to restrain the hyperplasia of fiber cell through intracameral injection after glaucoma filtration surgery, the research have not been reported. So it suggested a new hypothesis for intracameral injection of the triblock copolymers hydrogel as a new potential in situ sustained ophthalmic drug delivery system with antiscaring formation after glaucoma filtration surgery. Indicating that the new nanomaterials through intracameral injection treating complication of glaucoma filtration surgery is hoped to be a creative and promising ophthalmic drug delivery system in the future.
authors.affiliation: Department of Ophthalmology, The Affiliated Hospital of Luzhou Medical College, Luzhou of Sichuan Province 646000, People's Republic of China.
authors.forename: Yu
authors.initials: Y
authors.lastname: Qiao
authors.forename: Gang
authors.initials: G
authors.lastname: Qin
authors.forename: Ling
authors.initials: L
authors.lastname: Yu
mesh_terms: D060433:Administration, Ophthalmic; D002921:Cicatrix / Q000517:prevention & control*; D016503:Drug Delivery Systems / Q000379:methods*; D005901:Glaucoma / Q000601:surgery*; D020327:Glaucoma Drainage Implants; D006801:Humans; D020136:Hydrogel, Polyethylene Glycol Dimethacrylate / Q000627:therapeutic use*; D006965:Hyperplasia / Q000188:drug therapy; D008954:Models, Biological
chemical_list: D020136:Hydrogel, Polyethylene Glycol Dimethacrylate