title: [Ventilation in acute respiratory distress. Lung-protective strategies].
abstract: Ventilation of patients suffering from acute respiratory distress syndrome (ARDS) with protective ventilator settings is the standard in patient care. Besides the reduction of tidal volumes, the adjustment of a case-related positive end-expiratory pressure and preservation of spontaneous breathing activity at least 48 h after onset is part of this strategy. Bedside techniques have been developed to adapt ventilatory settings to the individual patient and the different stages of ARDS. This article reviews the pathophysiology of ARDS and ventilator-induced lung injury and presents current evidence-based strategies for ventilator settings in ARDS.
authors.affiliation: Klinik für Anästhesiologie, Universitätsklinikum der RWTH Aachen, Pauwelsstrasse 30, Aachen, Germany. cbruells@ukaachen.de
authors.forename: C S
authors.initials: CS
authors.lastname: Bruells
authors.forename: R
authors.initials: R
authors.lastname: Rossaint
authors.forename: R
authors.initials: R
authors.lastname: Dembinski
mesh_terms: D000399:Air Pressure; D003422:Critical Care / Q000379:methods*; D019317:Evidence-Based Medicine; D006801:Humans; D011175:Positive-Pressure Respiration / Q000379:methods*; D011650:Pulmonary Alveoli / Q000503:physiopathology; D011659:Pulmonary Gas Exchange / Q000502:physiology; D012128:Respiratory Distress Syndrome / Q000401:mortality / Q000628:therapy*; D012133:Respiratory Paralysis / Q000401:mortality / Q000503:physiopathology / Q000628:therapy; D012307:Risk Factors; D013990:Tidal Volume / Q000502:physiology; D055397:Ventilator-Induced Lung Injury / Q000401:mortality / Q000503:physiopathology / Q000517:prevention & control*