title: Effects of neurotensin dipeptide analog dilept on dopamine metabolism and synthesis in the nucleus accumbens of Wistar rats.
abstract: We studied the effects of neurotensin dipeptide analog Dilept (N-caproyl-L-prolyl-L-tyrosine methyl ester) on dopamine metabolism and synthesis in the nucleus accumbens of Wistar rats. Dilept increased the levels of dopamine and its metabolites (homovanillic acid and dioxyphenylalanine) and stimulated dopamine turnover in this structure. Dilept accelerated dopamine synthesis under conditions of pulsed activity blockade in dopaminergic neuron by injection of γ-butyrolactone combined with inhibition of aromatic acid decarboxylase with 3-hydroxybenzylhydrazine. The spectrum of pharmacological activities of Dilept towards the dopaminergic system of the nucleus accumbens was similar to that of atypical neuroleptics and neurotensin (endogenous antipsychotic).
authors.affiliation: VV Zakusov Institute of Pharmacology, Russian Academy of Medical Sciences, Moscow, Russia.
authors.forename: E V
authors.initials: EV
authors.lastname: Shubenina
authors.forename: V S
authors.initials: VS
authors.lastname: Kudrin
authors.forename: P M
authors.initials: PM
authors.lastname: Klodt
authors.forename: V B
authors.initials: VB
authors.lastname: Narkevich
authors.forename: E A
authors.initials: EA
authors.lastname: Kuznetsova
authors.forename: T A
authors.initials: TA
authors.lastname: Gudasheva
authors.forename: R U
authors.initials: RU
authors.lastname: Ostrovskaya
mesh_terms: D015107:4-Butyrolactone / Q000494:pharmacology; D000818:Animals; D065105:Aromatic Amino Acid Decarboxylase Inhibitors; D004298:Dopamine / Q000096:biosynthesis* / Q000378:metabolism*; D006834:Hydrazines / Q000494:pharmacology; D009474:Neurons / Q000187:drug effects / Q000378:metabolism*; D009714:Nucleus Accumbens / Q000187:drug effects / Q000378:metabolism*; D011392:Proline / Q000031:analogs & derivatives* / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D014443:Tyrosine / Q000031:analogs & derivatives* / Q000494:pharmacology
chemical_list: D065105:Aromatic Amino Acid Decarboxylase Inhibitors; C401484:GZR 123; D006834:Hydrazines; D014443:Tyrosine; D011392:Proline; C004297:3-hydroxybenzylhydrazine; D015107:4-Butyrolactone; D004298:Dopamine