title: Expression of peroxiredoxin 1, 2, 3, and 6 genes in cancer cells during drug resistance formation.
abstract: We studied the expression of peroxiredoxin genes (PRDX1, PRDX2, PRDX3, and PRDX6) in human erythroleukemia K652, human breast carcinoma MCF-7, and human ovarian carcinoma SKOV-3 cells during cisplatin resistance development. It was found that drug resistance formation was accompanied by a significant increase in the expression of PRDX1, PRDX2, PRDX3, PRDX6 genes in all cancer cell strains, which confirms the important contribution of redox-dependent mechanisms into the development of cisplatin resistance of cancer cells.
authors.affiliation: People's Friendship University of Russia, Moscow, Russia. kevsan@orc.ru
authors.forename: E V
authors.initials: EV
authors.lastname: Kalinina
authors.forename: T T
authors.initials: TT
authors.lastname: Berezov
authors.forename: A A
authors.initials: AA
authors.lastname: Shtil'
authors.forename: N N
authors.initials: NN
authors.lastname: Chernov
authors.forename: V A
authors.initials: VA
authors.lastname: Glazunova
authors.forename: M D
authors.initials: MD
authors.lastname: Novichkova
authors.forename: N K
authors.initials: NK
authors.lastname: Nurmuradov
mesh_terms: D000970:Antineoplastic Agents / Q000494:pharmacology; D001943:Breast Neoplasms / Q000188:drug therapy / Q000201:enzymology / Q000235:genetics*; D002277:Carcinoma / Q000188:drug therapy / Q000201:enzymology / Q000235:genetics*; D045744:Cell Line, Tumor; D002945:Cisplatin / Q000494:pharmacology; D019008:Drug Resistance, Neoplasm / Q000187:drug effects / Q000235:genetics; D005260:Female; D015870:Gene Expression / Q000187:drug effects; D006801:Humans; D004915:Leukemia, Erythroblastic, Acute / Q000188:drug therapy / Q000201:enzymology / Q000235:genetics*; D010051:Ovarian Neoplasms / Q000188:drug therapy / Q000201:enzymology / Q000235:genetics*; D018384:Oxidative Stress; D061105:Peroxiredoxin III / Q000235:genetics* / Q000378:metabolism; D054465:Peroxiredoxin VI / Q000235:genetics* / Q000378:metabolism; D054464:Peroxiredoxins / Q000235:genetics* / Q000378:metabolism
chemical_list: D000970:Antineoplastic Agents; C515940:PRDX1 protein, human; C086065:PRDX2 protein, human; C516115:PRDX3 protein, human; C515977:PRDX6 protein, human; D061105:Peroxiredoxin III; D054465:Peroxiredoxin VI; D054464:Peroxiredoxins; D002945:Cisplatin