title: Neuromyelitis optica spectrum disorder: 2-deoxy-2-[18F]fluoro-D-glucose positron emission tomography findings--case report.
abstract: A 51-year-old female with a history of rheumatoid arthritis rapidly developed anterior neck pain and paresis in the left upper and lower extremities and right lower extremity, sensory disturbance in the left upper and lower extremities, and bladder and rectal disorder. Adduction of the left eye and abduction of the right eye were also disturbed. Spinal magnetic resonance imaging demonstrated severe edema in the C1-T5 levels, which then deteriorated rapidly over 3 days, and lesions enhanced with gadolinium in the C1-C3 and C5-T3 levels. 2-Deoxy-2-[18F]fluoro-D-glucose positron emission tomography study demonstrated the inflammatory sites as segmental enhanced accumulation in the C1-C3, C5-C6, and T1 levels. The serum anti-aquaporin 4 antibody level was positive and she was diagnosed with neuromyelitis optica spectrum disorder. Marked improvement in the neurological conditions, concomitant with reduced spinal cord edema, was obtained by steroid pulse therapy.
authors.affiliation: Department of Neurosurgery, Ogaki Municipal Hospital, Ogaki, Gifu, Japan. oya3776@arrow.ocn.ne.jp
authors.forename: Hirofumi
authors.initials: H
authors.lastname: Oyama
authors.forename: Shigeru
authors.initials: S
authors.lastname: Miwa
authors.forename: Tomoyuki
authors.initials: T
authors.lastname: Noda
authors.forename: Atsuhiro
authors.initials: A
authors.lastname: Sobajima
authors.forename: Akira
authors.initials: A
authors.lastname: Kito
authors.forename: Hideki
authors.initials: H
authors.lastname: Maki
authors.forename: Kenichi
authors.initials: K
authors.lastname: Hattori
authors.forename: Kentaro
authors.initials: K
authors.lastname: Wada
mesh_terms: D000284:Administration, Oral; D051401:Aquaporin 4 / Q000276:immunology; D001323:Autoantibodies / Q000097:blood; D002574:Cervical Vertebrae; D004359:Drug Therapy, Combination; D004487:Edema / Q000000981:diagnostic imaging / Q000188:drug therapy; D005260:Female; D019788:Fluorodeoxyglucose F18; D006801:Humans; D007262:Infusions, Intravenous; D008279:Magnetic Resonance Imaging; D008776:Methylprednisolone Hemisuccinate / Q000008:administration & dosage; D008875:Middle Aged; D009188:Myelitis, Transverse / Q000000981:diagnostic imaging* / Q000188:drug therapy; D009460:Neurologic Examination; D009471:Neuromyelitis Optica / Q000000981:diagnostic imaging* / Q000188:drug therapy; D049268:Positron-Emission Tomography; D011239:Prednisolone / Q000008:administration & dosage; D020551:Pulse Therapy, Drug; D013116:Spinal Cord / Q000000981:diagnostic imaging* / Q000187:drug effects; D013904:Thoracic Vertebrae
chemical_list: C496030:AQP4 protein, human; D051401:Aquaporin 4; D001323:Autoantibodies; D019788:Fluorodeoxyglucose F18; D008776:Methylprednisolone Hemisuccinate; D011239:Prednisolone