title: [Evaluation of the actoprotective action of a heteroaromatic antioxidant].
abstract: Experiments with mice showed that heteroaromatic antioxidant IBKhF-11 (intraperitoneally 1 mg/kg) alters the main individual behavior characteristics in the open field test, lessens stress from running on treadmill, reduces oxygen consumption by 33-37% over 3 hours and decreases rectal temperature by 2.4 degrees C at the most. In fact, IBKhF-11 stimulates the anaerobic pathway of energy production during physical work by increasing glucose level etc., and corrects shifts in such biochemical parameters of blood serum as total bilirubin, uric acid and triglycerides and enzyme activities. The low-toxicity compound (intraperitoneal injection of no more than 1500 mg/kg of LD50 on the average) has every potential to appear on the market in the form of performance enhancing drugs.
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000008:administration & dosage / Q000494:pharmacology* / Q000633:toxicity; D001522:Behavior, Animal / Q000187:drug effects*; D001831:Body Temperature / Q000187:drug effects; D004734:Energy Metabolism; D005947:Glucose / Q000378:metabolism; D007274:Injections, Intraperitoneal; D007928:Lethal Dose 50; D051379:Mice; D010101:Oxygen Consumption / Q000187:drug effects*; D012420:Running / Q000502:physiology
chemical_list: D000975:Antioxidants; D005947:Glucose