title: Toxicity of cadmium and protective effect of bee honey, vitamins C and B complex.
abstract: The present work aimed to study the toxic effect of cadmium (Cd) on rabbits' blood indices, as well as the therapeutic effect of the antioxidant agents, vitamins C and B complex and bee honey on Cd intoxicated rabbits. Cadmium chloride (CdCl2) was injected subcutaneously at a dose of 3 mg/kg of body weight. The results showed a significant increase in serum glucose, triglycerides, cholesterol, total protein, albumin, globulin, urea and creatinine, compared to the control group. In addition, CdCl2 intoxication increased the levels of uric acid, aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase and bilirubin. Concerning haematological parameters, the more obvious changes were an increase in mean corpuscular volume and a decrease in white blood cells count, platelets, lymphocytes, heamatocrit, haemoglobin and red blood cells count. Treatment of CdCl2-intoxicated animals with vitamins C and B complex and bee honey showed a decrease in the harmful effects of Cd by restoring haematological and biochemical changes. Bee honey treatment was the most effective in providing recoveries in the altered blood parameters.
authors.affiliation: Biology Department, The Islamic University of Gaza, Palestine.
authors.forename: I
authors.initials: I
authors.lastname: Abdelaziz
authors.forename: M I
authors.initials: MI
authors.lastname: Elhabiby
authors.forename: A A
authors.initials: AA
authors.lastname: Ashour
mesh_terms: D000410:Alanine Transaminase / Q000097:blood; D000469:Alkaline Phosphatase / Q000097:blood; D000818:Animals; D001205:Ascorbic Acid / Q000494:pharmacology*; D001219:Aspartate Aminotransferases / Q000097:blood; D001663:Bilirubin / Q000097:blood; D001772:Blood Cell Count; D001786:Blood Glucose / Q000032:analysis; D019256:Cadmium Chloride / Q000633:toxicity*; D002784:Cholesterol / Q000097:blood; D003404:Creatinine / Q000097:blood; D004785:Environmental Pollutants / Q000633:toxicity*; D005916:Globulins / Q000032:analysis; D006722:Honey; D020011:Protective Agents / Q000494:pharmacology*; D011817:Rabbits; D012709:Serum Albumin / Q000032:analysis; D014280:Triglycerides / Q000097:blood; D014508:Urea / Q000097:blood; D014527:Uric Acid / Q000097:blood; D014803:Vitamin B Complex / Q000494:pharmacology*
chemical_list: D001786:Blood Glucose; D004785:Environmental Pollutants; D005916:Globulins; D020011:Protective Agents; D012709:Serum Albumin; D014280:Triglycerides; D014803:Vitamin B Complex; D014527:Uric Acid; D014508:Urea; D002784:Cholesterol; D003404:Creatinine; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase; D000469:Alkaline Phosphatase; D019256:Cadmium Chloride; D001205:Ascorbic Acid; D001663:Bilirubin