title: An efficient synthesis of novel dispirooxindole derivatives via one-pot three-component 1,3-dipolar cycloaddition reactions.
abstract: A series of novel dispirooxindoles have been synthesized through  three-component 1,3-dipolar cycloaddition of azomethine ylides generated in situ by the decarboxylative condensation of isatin and an α-amino acid with the dipolarophile  5-benzylidene-1,3-dimethylpyrimidine-2,4,6-trione. This method has the advantages of mild reaction conditions, high atom economy, excellent yields, and high regio- and  stereo-selectivity.
authors.affiliation: Key Laboratory of Organic Synthesis of Jiangsu Province, College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou 215123, China.
authors.forename: Zhibin
authors.initials: Z
authors.lastname: Huang
authors.forename: Qian
authors.initials: Q
authors.lastname: Zhao
authors.forename: Gang
authors.initials: G
authors.lastname: Chen
authors.forename: Huiyuan
authors.initials: H
authors.lastname: Wang
authors.forename: Wei
authors.initials: W
authors.lastname: Lin
authors.forename: Lexing
authors.initials: L
authors.lastname: Xu
authors.forename: Hongtao
authors.initials: H
authors.lastname: Liu
authors.forename: Juxian
authors.initials: J
authors.lastname: Wang
authors.forename: Daqing
authors.initials: D
authors.lastname: Shi
authors.forename: Yucheng
authors.initials: Y
authors.lastname: Wang
mesh_terms: D001391:Azo Compounds / Q000737:chemistry; D018360:Crystallography, X-Ray; D061565:Cycloaddition Reaction; D005583:Fourier Analysis; D007211:Indoles / Q000138:chemical synthesis* / Q000737:chemistry; D008958:Models, Molecular; D008968:Molecular Conformation; D011743:Pyrimidines / Q000737:chemistry; D012521:Sarcosine / Q000737:chemistry; D013141:Spiro Compounds / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D001391:Azo Compounds; D007211:Indoles; D011743:Pyrimidines; D013141:Spiro Compounds; D012521:Sarcosine