title: Daptomycin concentrations in valve tissue and vegetation in patients with bacterial endocarditis.
abstract: In a patient with mitral-aortic native-valve Streptococcus oralis endocarditis, daptomycin concentrations in aortic and mitral valves were 8.6 and 30.8 μg/g, respectively, and 26 μg/g in the mitral vegetation. In the case of porcine-aortic-valve Staphylococcus epidermidis endocarditis, the daptomycin concentrations were 53.1 μg/g in the valve and 18.1 μg/g in perivalvular tissues. Daptomycin achieved apparently adequate tissue concentrations. S. epidermidis was eradicated, whereas Streptococcus oralis persisted, and its daptomycin MIC displayed a 4-fold increase.
authors.affiliation: U.O.C. Malattie Infettive, Azienda Ospedaliera Universitaria Pisana, Pisa, Italy. c.tascini@ao-pisa.toscana.it
authors.forename: Carlo
authors.initials: C
authors.lastname: Tascini
authors.forename: Antonello
authors.initials: A
authors.lastname: Di Paolo
authors.forename: Roberta
authors.initials: R
authors.lastname: Poletti
authors.forename: Sarah
authors.initials: S
authors.lastname: Flammini
authors.forename: Michele
authors.initials: M
authors.lastname: Emdin
authors.forename: Ilaria
authors.initials: I
authors.lastname: Ciullo
authors.forename: Enrico
authors.initials: E
authors.lastname: Tagliaferri
authors.forename: Annette
authors.initials: A
authors.lastname: Moter
authors.forename: Francesco
authors.initials: F
authors.lastname: Menichetti
mesh_terms: D000368:Aged; D000818:Animals; D000900:Anti-Bacterial Agents / Q000493:pharmacokinetics* / Q000494:pharmacology / Q000627:therapeutic use; D001021:Aortic Valve / Q000473:pathology / Q000601:surgery; D001705:Bioprosthesis / Q000382:microbiology*; D017576:Daptomycin / Q000493:pharmacokinetics* / Q000494:pharmacology / Q000627:therapeutic use; D004697:Endocarditis, Bacterial / Q000188:drug therapy* / Q000382:microbiology; D006350:Heart Valve Prosthesis / Q000382:microbiology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D008943:Mitral Valve / Q000473:pathology / Q000601:surgery; D013203:Staphylococcal Infections / Q000188:drug therapy* / Q000382:microbiology; D013210:Staphylococcus / Q000187:drug effects / Q000254:growth & development; D013212:Staphylococcus epidermidis / Q000187:drug effects / Q000254:growth & development; D013552:Swine
chemical_list: D000900:Anti-Bacterial Agents; D017576:Daptomycin