title: pH-triggered aggregate shape of different generations lysine-dendronized maleimide copolymers with maltose shell.
abstract: Glycopolymers are promising materials in the field of biomedical applications and in the fabrication of supramolecular structures with specific functions. For tunable design of supramolecular structures, glycopolymer architectures with specific properties (e.g., controlled self-assembly) are needed. Using the concept of dendronized polymers, a series of H-bond active giant glycomacromolecules with maleimide backbone and lysine dendrons of different generations were synthesized. They possess different macromolecular size and functionality along the backbone. Their peripheral maltose units lead to solubility under physiological conditions and controlled aggregation behavior. The aggregation behavior was investigated depending on generation number, pH value, and concentration. A portfolio of complementary analytical tools give an insight into the influence of the different parameters in shaping a rod-, coil-, and worm-like molecular structure and their controlled aggregate formation. MD simulation helped us to understand the complex aggregation behavior of the linear polymer chain without dendritic units.
authors.affiliation: Leibniz-Institut für Polymerforschung Dresden, Hohe Str. 6, 01109 Dresden, Germany.
authors.forename: S
authors.initials: S
authors.lastname: Boye
authors.forename: D
authors.initials: D
authors.lastname: Appelhans
authors.forename: V
authors.initials: V
authors.lastname: Boyko
authors.forename: S
authors.initials: S
authors.lastname: Zschoche
authors.forename: H
authors.initials: H
authors.lastname: Komber
authors.forename: P
authors.initials: P
authors.lastname: Friedel
authors.forename: P
authors.initials: P
authors.lastname: Formanek
authors.forename: A
authors.initials: A
authors.lastname: Janke
authors.forename: B I
authors.initials: BI
authors.lastname: Voit
authors.forename: A
authors.initials: A
authors.lastname: Lederer
mesh_terms: D001672:Biocompatible Materials / Q000737:chemistry; D002850:Chromatography, Gel; D050091:Dendrimers / Q000737:chemistry*; D031521:Fractionation, Field Flow; D006863:Hydrogen-Ion Concentration; D008239:Lysine / Q000737:chemistry*; D046911:Macromolecular Substances; D008301:Maleimides / Q000737:chemistry*; D008320:Maltose / Q000737:chemistry*; D018625:Microscopy, Atomic Force; D046529:Microscopy, Electron, Transmission; D008958:Models, Molecular; D056004:Molecular Dynamics Simulation; D015394:Molecular Structure; D011108:Polymers / Q000737:chemistry*
chemical_list: D001672:Biocompatible Materials; D050091:Dendrimers; D046911:Macromolecular Substances; D008301:Maleimides; D011108:Polymers; C043592:maleimide; D008320:Maltose; D008239:Lysine