title: Copper-catalyzed aerobic oxidative synthesis of α-ketoamides from methyl ketones, amines and NIS at room temperature.
abstract: A simple, efficient and practical copper-catalyzed aerobic oxidative synthesis of α-ketoamides from aryl methyl ketones, aliphatic amines and N-iodosuccinimide (NIS) has been developed. The one-pot reaction may proceed smoothly at room temperature in the open air. The possible mechanism for the formation of α-ketoamides was proposed. Molecular oxygen in air functions as both an oxidant and an oxygen source.
authors.affiliation: Department of Chemistry, Northeast Normal University, Changchun 130024, China.
authors.forename: Juan
authors.initials: J
authors.lastname: Zhang
authors.forename: Ying
authors.initials: Y
authors.lastname: Wei
authors.forename: Shaoxia
authors.initials: S
authors.lastname: Lin
authors.forename: Fushun
authors.initials: F
authors.lastname: Liang
authors.forename: Pengjun
authors.initials: P
authors.lastname: Liu
mesh_terms: D000388:Air; D000577:Amides / Q000138:chemical synthesis*; D000588:Amines / Q000737:chemistry*; D002384:Catalysis; D003300:Copper / Q000737:chemistry*; D007659:Ketones / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D010084:Oxidation-Reduction; D010100:Oxygen / Q000737:chemistry*; D013237:Stereoisomerism; D013388:Succinimides / Q000737:chemistry*; D013696:Temperature
chemical_list: D000577:Amides; D000588:Amines; D007659:Ketones; D013388:Succinimides; C008155:N-iodosuccinimide; D003300:Copper; D010100:Oxygen