title: Trends of HIV-1, HIV-2 and dual infection in women attending outpatient clinics in Senegal, 1990-2009.
abstract: We assessed trends in the relative prevalences of HIV-1, HIV-2 and dual HIV-1/HIV-2 infection in 10,321 women attending outpatient clinics in Senegal between 1990 and 2009. The relative prevalence of HIV-1 (defined as the proportion of seropositive subjects having HIV-1) rose sharply from 38% in 1990 until 1993 (P < 0.001), whereupon it continued to rise, but at a slower rate, reaching 72% of HIV infections in 2009. As compared with HIV-1, the relative prevalence of HIV-2 decreased sharply from 54% in 1990 until 1993 (P < 0.001) and continued to decrease at a slower rate through 2009. The relative prevalence of dual infection, as compared with HIV-1, was stable from 1990 to 1993, but decreased slightly thereafter (P < 0.001). These study findings indicate that during the early 1990s, the relative prevalence of HIV-1 increased markedly, while the relative prevalence of HIV-2 decreased and the relative prevalence of dual infection remained stable in Senegal. From 1993 to 2009, the relative prevalence of HIV-1 increased at a slower rate, while the relative prevalences of HIV-2 and dual infection decreased. These results confirm trends in HIV prevalence observed in other West African populations and provide a critical update on HIV transmission risk among women in Senegal.
authors.affiliation: Department of Epidemiology, School of Public Health, University of Washington, Box 357236, Seattle, WA 98195, USA. heitzk@uw.edu
authors.forename: K
authors.initials: K
authors.lastname: Heitzinger
authors.forename: P S
authors.initials: PS
authors.lastname: Sow
authors.forename: N M
authors.initials: NM
authors.lastname: Dia Badiane
authors.forename: G S
authors.initials: GS
authors.lastname: Gottlieb
authors.forename: I
authors.initials: I
authors.lastname: N'Doye
authors.forename: M
authors.initials: M
authors.lastname: Toure
authors.forename: N B
authors.initials: NB
authors.lastname: Kiviat
authors.forename: S E
authors.initials: SE
authors.lastname: Hawes
mesh_terms: D000328:Adult; D060085:Coinfection / Q000453:epidemiology* / Q000821:virology*; D005260:Female; D015658:HIV Infections / Q000453:epidemiology* / Q000821:virology*; D015497:HIV-1 / Q000302:isolation & purification*; D015498:HIV-2 / Q000302:isolation & purification*; D006801:Humans; D016015:Logistic Models; D008403:Mass Screening / Q000706:statistics & numerical data; D008875:Middle Aged; D015995:Prevalence; D012189:Retrospective Studies; D012675:Senegal / Q000453:epidemiology