title: Cefepime versus ceftazidime as empirical therapy for fever in neutropenic patients with haematological malignancies.
abstract: An open randomized comparative study was conducted to evaluate the efficacy of Cefepime (2 gm iv. 8 hr.) vs. ceftazidime (2 gm iv. every 8 hr.) in empirical therapy of febrile neutropenic patients. A total of 40 eligible febrile episodes were randomized to be treated with study regimen. Twenty febrile episodes were treated with cefepime and 20 were treated with ceftazidime. The two groups were comparable in terms of age, sex, height, underlying neoplasm, number of pretherapy neutrophils, duration of neutropenia. The overall therapeutic success rate of cetepime group (60%) was comparable to that of ceftazidime group (55%). The results of this study suggest that cefepime is an effective and safe agent in empirical therapy of febrile episode in neutropenic patient and its efficacy is comparable with that of ceftazidime.
authors.affiliation: Departments of Medicine, Microbiology and Biochemistry Pt., B.D.Sharma Post Graduate Institute of Medical Sciences, 216J, Medical Campus, Rohtak, 124 001 India.
authors.forename: P S
authors.initials: PS
authors.lastname: Ghalaut
authors.forename: Uma
authors.initials: U
authors.lastname: Chaudhry
authors.forename: Veena Singh
authors.initials: VS
authors.lastname: Ghalaut
authors.forename: Sameer
authors.initials: S
authors.lastname: Aggarwal
authors.forename: Vinny
authors.initials: V
authors.lastname: Sood
authors.forename: Gaurav
authors.initials: G
authors.lastname: Dixit