title: A multi-parameter decoupling method with a Lamb wave sensor for improving the selectivity of label-free liquid detection.
abstract: In this paper, a liquid multi-parameter decoupling method with only one Lamb wave sensor is presented. In a Lamb wave sensor, antisymmetric modes (A(01) mode for low frequency, A(03) mode for high frequency) and symmetric modes (S(0) mode) are used to detect multiple parameters of a liquid, such as its density, sound velocity, and viscosity. We found they can play very different roles in the detections. For example, the A(01) mode is very sensitive to the liquid's density but the A(03) mode is sensitive to the sound velocity. Here, the A(0) mode is used to identify the density of the detected liquid and with this density value we obtained the viscosity by the amplitude shifts of the S(0) mode. This could be a way to distinguish an unknown liquid with high sensitivity or to solve the problem of selectivity of label-free detection on biosensors.
authors.affiliation: Suzhou Institute of Biomedical Engineering and Technology, Chinese Academy of Sciences, Suzhou 215163, China. zhoulq@sibet.ac.cn
authors.forename: Lianqun
authors.initials: L
authors.lastname: Zhou
authors.forename: Yihui
authors.initials: Y
authors.lastname: Wu
authors.forename: Ming
authors.initials: M
authors.lastname: Xuan
authors.forename: Jean-François
authors.initials: JF
authors.lastname: Manceau
authors.forename: François
authors.initials: F
authors.lastname: Bastien
mesh_terms: D000162:Acoustics / Q000295:instrumentation*; D015374:Biosensing Techniques / Q000295:instrumentation; D001965:Bromides / Q000737:chemistry; D002623:Chemistry Techniques, Analytical / Q000295:instrumentation* / Q000379:methods; D004581:Electronics; D055616:Microtechnology / Q000295:instrumentation; D012815:Signal Processing, Computer-Assisted; D012965:Sodium Chloride / Q000737:chemistry; D017670:Sodium Compounds / Q000737:chemistry; D012996:Solutions / Q000032:analysis / Q000737:chemistry*; D013016:Sound; D014783:Viscosity
chemical_list: D001965:Bromides; D017670:Sodium Compounds; D012996:Solutions; D012965:Sodium Chloride; C027938:sodium bromide
keywords: Lamb wave sensor; density; determination of multi-parameters; sound velocity; viscosity