title: New 14-membered cyclopeptide alkaloids from Zizyphus oxyphylla Edgew.
abstract: Two new 14-membered cyclopeptide alkaloids, Oxyphylline B (4) and Oxyphylline C (5), along with three known 13-membered cyclopeptide alkaloids, were isolated from stem and roots of Zizyphus oxyphylla Edgew. The compounds were tested for antibacterial activity. Oxyphylline B (4) showed comparatively better antibacterial activities against Escherichia coli (MIC, 5 μg/mL) than other compounds. This compound also exhibited weak antimicrobial activities against Staphylococcus aureus (MIC, 25 μg/mL), Pseudomonas aeruginosa (MIC, 50 μg/mL) and Salmonella typhi (MIC, 50 μg/mL).
authors.affiliation: Department of Pharmacy, Abdul Wali Khan University Mardan, Anbar Campus 23200, Pakistan.
authors.forename: Waqar Ahmad
authors.initials: WA
authors.lastname: Kaleem
authors.affiliation: Institute of Chemical Sciences, University of Peshawar, Peshawar 25120, Pakistan.
authors.forename: Muhammad
authors.initials: M
authors.lastname: Nisar
authors.affiliation: Institute of Pharmaceutical Sciences, Kohat University of Science and Technology, Kohat 2600, Pakistan.
authors.forename: Mughal
authors.initials: M
authors.lastname: Qayum
authors.affiliation: Research Institute of Pharmaceutical Sciences, Department of Pharmacognosy, University of Karachi, Karachi 75270, Pakistan.
authors.forename: Muhammad
authors.initials: M
authors.lastname: Zia-Ul-Haq
authors.affiliation: H.E.J. Research Institute of Chemistry, International Center for Chemical and biological Sciences, University of Karachi, Karachi 75270, Pakistan.
authors.forename: Achyut
authors.initials: A
authors.lastname: Adhikari
authors.affiliation: Department of Pharmaceutical and Biomedical Sciences, Universiy of Salerno, Salerno 84100, Italy.
authors.forename: Vincenzo
authors.identifier: 0000-0002-1070-3207
authors.initials: V
authors.lastname: De Feo
mesh_terms: D000470:Alkaloids / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D004926:Escherichia coli / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D010456:Peptides, Cyclic / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D018517:Plant Roots / Q000378:metabolism; D018547:Plant Stems / Q000378:metabolism; D011550:Pseudomonas aeruginosa / Q000187:drug effects; D012485:Salmonella typhi / Q000187:drug effects; D013211:Staphylococcus aureus / Q000187:drug effects; D013806:Theophylline / Q000031:analogs & derivatives* / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D031957:Ziziphus / Q000378:metabolism*
chemical_list: D000470:Alkaloids; D000900:Anti-Bacterial Agents; D010456:Peptides, Cyclic; D013806:Theophylline; C008749:etofylline
keywords: Zizyphus oxyphylla Edgew; antibacterial activity; cyclopeptide alkaloids