title: Energy deficit as a possible factor for the induction of caspase-dependent apoptosis in left ventricular myocardial cells during genetically determined and secondary arterial hypertension.
abstract: Activities of caspase-3 and caspase-8 in the left ventricular myocardium of Chinchilla rabbits with renovascular arterial hypertension and spontaneously hypertensive rats were measured after 10-day administration of a macroergic compound phosphocreatine. Treatment with phosphocreatine prevented activation of caspase-3, but had no effect on caspase-8 during secondary and genetically determined arterial hypertension. Our results indicate that the intrinsic mechanism of the induction of the caspase cascade in myocardial cells dominates over the extrinsic pathway during both types of arterial hypertension. Energy deficit is one of the inducing factors of these processes.
authors.affiliation: Department of General Pathology and Pathophysiology, People's Friendship University of Russia, Moscow, Russia. azovam@mail.ru
authors.forename: M M
authors.initials: MM
authors.lastname: Azova
authors.forename: M L
authors.initials: ML
authors.lastname: Blagonravov
authors.forename: E A
authors.initials: EA
authors.lastname: Demurov
authors.forename: V A
authors.initials: VA
authors.lastname: Frolov
mesh_terms: D000818:Animals; D017209:Apoptosis / Q000187:drug effects*; D002316:Cardiotonic Agents / Q000378:metabolism / Q000494:pharmacology*; D053148:Caspase 3 / Q000235:genetics / Q000378:metabolism; D053181:Caspase 8 / Q000235:genetics / Q000378:metabolism; D004734:Energy Metabolism / Q000187:drug effects*; D015870:Gene Expression / Q000187:drug effects; D006352:Heart Ventricles / Q000737:chemistry* / Q000187:drug effects / Q000378:metabolism; D006978:Hypertension, Renovascular / Q000188:drug therapy / Q000235:genetics / Q000378:metabolism* / Q000503:physiopathology; D008297:Male; D009206:Myocardium / Q000378:metabolism*; D010725:Phosphocreatine / Q000378:metabolism / Q000494:pharmacology*; D011817:Rabbits; D051381:Rats; D011918:Rats, Inbred SHR; D011921:Rats, Inbred WKY
chemical_list: D002316:Cardiotonic Agents; D010725:Phosphocreatine; D053148:Caspase 3; D053181:Caspase 8