title: [Pulmonary hypertension: from molecular pathophysiology to haemodynamic abnormalities].
abstract: Pulmonary hypertension (PH) is a complex disorder resulting from many etiologies that cause disturbances of normal pulmonary haemodynamics. Recent breakthroughs have led to a better understanding of the pathophysiology of the disease. In PH, haemodynamic disturbances are closely linked to structural changes and excessive remodeling of pulmonary vessels, leading to progressive narrowing of the pulmonary vascular lumen. Imbalances between pulmonary vasoconstrictors and vasodilators on the one hand, and factors favoring cell proliferation and apoptosis on the other hand, probably account for most cases of PH. This review aims to update readers with the current knowledge on the molecular physiopathology of PH and how this can progress the therapeutic of this disorder.
authors.affiliation: Service de physiologie, explorations fonctionnelles, hôpital Cochin, UPRES EA 2511, faculté de médecine, université Paris Descartes, 27, rue du Faubourg-Saint-Jacques, 75104 Paris, France. sy.duong-quy@cch.aphp.fr
authors.forename: S
authors.initials: S
authors.lastname: Duong-Quy
authors.forename: S
authors.initials: S
authors.lastname: Rivière
authors.forename: Y
authors.initials: Y
authors.lastname: Bei
authors.forename: C
authors.initials: C
authors.lastname: Duong-Ngo
authors.forename: N N
authors.initials: NN
authors.lastname: Le-Dong
authors.forename: T
authors.initials: T
authors.lastname: Hua-Huy
authors.forename: A T
authors.initials: AT
authors.lastname: Dinh-Xuan
mesh_terms: D017209:Apoptosis; D055396:Bone Morphogenetic Protein 2 / Q000235:genetics; D049109:Cell Proliferation; D018450:Disease Progression; D004730:Endothelium, Vascular / Q000503:physiopathology*; D006439:Hemodynamics; D006801:Humans; D006976:Hypertension, Pulmonary / Q000145:classification / Q000209:etiology / Q000235:genetics / Q000473:pathology / Q000503:physiopathology* / Q000628:therapy; D009154:Mutation / Q000235:genetics; D009389:Neovascularization, Pathologic / Q000235:genetics; D009569:Nitric Oxide / Q000378:metabolism; D015398:Signal Transduction / Q000235:genetics; D014655:Vascular Resistance; D014661:Vasoconstriction; D014664:Vasodilation
chemical_list: C525718:BMP2 protein, human; D055396:Bone Morphogenetic Protein 2; D009569:Nitric Oxide