title: Birth defects data from surveillance hospitals in hubei province, china, 200l - 2008.
abstract: BACKGROUND
  To determine the prevalence and characteristics of birth defects in perinatal infants in Hubei Province during 200l-2008.
  
  
  METHODS
  The prevalence of birth defects in perinatal infants delivered after 28 weeks or more was analyzed in Hubei surveillance hospitals during 200l-2008.
  
  
  RESULTS
  The incidence of birth defects in perinatal infants from 200l to 2008 was 120.0 per 10,000 births, and was increased by about 41% from 81. 1 in 2001 to 138.5 per 10,000 births in 2008. The incidence in the first 4 years (2005-2008) was much higher than the latter four (2001-2004) (χ(2)=77.64, P <0.05). The difference in prevalence between urban and rural was of no significance in 2008 (χ(2)=0.03, P >0.05), but that between male and female was significant (χ(2)=5.24, P <0.05), as the former prevalence was much higher. The prevalence of birth defects was slightly higher among mothers over 35 years old than those under 35 years old, but with no significance (χ(2)=1.98, P >0.05). The two leading birth defects were cleft lip and/or palate and polydactyly, followed by congenital heart disease, hydrocephaly, external ear malformation and neural tube defects. The prevalence of congenital heart disease was rising.
  
  
  CONCLUSIONS
  Eight years' birth defects data indicate that the birth defect rate was on the rise and the birth defects prevalence in Hubei province should be valued.
authors.affiliation: Family Planning Research Institute, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China.
authors.forename: Lh
authors.initials: L
authors.lastname: Tu
authors.forename: H
authors.initials: H
authors.lastname: Li
authors.forename: Hp
authors.initials: H
authors.lastname: Zhang
authors.forename: Xd
authors.initials: X
authors.lastname: Li
authors.forename: Jj
authors.initials: J
authors.lastname: Lin
authors.forename: Cl
authors.initials: C
authors.lastname: Xiong
keywords: Birth defect; Perinatal infants; Prevalence; Prevention; Surveillance