title: Invasive pneumococcal disease and 7-valent pneumococcal conjugate vaccine, the Netherlands.
abstract: In the Netherlands, the national immunization program includes 7-valent pneumococcal conjugate vaccine (PCV7) for all newborns born after April 1, 2006. We compared the incidence of invasive pneumococcal disease (IPD) and patient and disease characteristics before PCV7 introduction (June 2004-June 2006) with those after PCV7 introduction (June 2008-June 2010). Culture-confirmed IPD cases were identified by 9 sentinel laboratories covering ≈25% of the Dutch population. Significant declines in overall IPD incidence were observed in children <2 (60%) and in persons >65 (13%) years of age. A trend toward gradual increases in non-PCV7 serotype IPD infections was observed in all age groups; the largest increases were among persons 50-64 (37%) and >65 (25%) years of age. In adults, the proportion of immunocompromised persons increased among IPD patients. Overall, deaths from IPD decreased from 16% to 12% because of a lower case-fatality rate for persons with non-PCV7 serotype IPD.
authors.forename: Anna M M
authors.initials: AM
authors.lastname: van Deursen
authors.forename: Suzan P
authors.initials: SP
authors.lastname: van Mens
authors.forename: Elisabeth A M
authors.initials: EA
authors.lastname: Sanders
authors.forename: Bart J M
authors.initials: BJ
authors.lastname: Vlaminckx
authors.forename: Hester E
authors.initials: HE
authors.lastname: de Melker
authors.forename: Leo M
authors.initials: LM
authors.lastname: Schouls
authors.forename: Sabine C
authors.initials: SC
authors.lastname: de Greeff
authors.forename: Arie
authors.initials: A
authors.lastname: van der Ende
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002648:Child; D002675:Child, Preschool; D006801:Humans; D017589:Immunization Programs; D015994:Incidence; D007223:Infant; D008875:Middle Aged; D009426:Netherlands / Q000453:epidemiology; D011008:Pneumococcal Infections / Q000453:epidemiology* / Q000276:immunology / Q000517:prevention & control*; D022242:Pneumococcal Vaccines / Q000276:immunology; D011159:Population Surveillance; D012189:Retrospective Studies; D012703:Serotyping; D013296:Streptococcus pneumoniae / Q000145:classification / Q000276:immunology; D018074:Vaccines, Conjugate / Q000276:immunology; D055815:Young Adult
chemical_list: D022242:Pneumococcal Vaccines; D018074:Vaccines, Conjugate