title: Asymmetric trifluoromethylation of aromatic aldehydes by cooperative catalysis with (IPr)CuF and quinidine-derived quaternary ammonium salt.
abstract: A general enantioselective trifluoromethylation of aldehydes has been developed using (IPr)CuF and quinidine-derived quaternary ammonium salt as the cooperative catalyst. Thus, a wide range of aromatic aldehydes have been converted to the corresponding products in up to 92% yield and 81% ee at 2 mol% of catalyst loading. The greatly enhanced activity and enantioselectivity result from the initiative generation of active [(IPr)CuCF(3)] as well as additional coordination activation of other copper species.
authors.affiliation: Department of Applied Chemistry, School of Chemical Engineering & the Environment, Beijing Institute of Technology, No. 5 South Zhongguancun Street, Haidian District, Beijing 100081, PR China.
authors.forename: Shaoxiang
authors.initials: S
authors.lastname: Wu
authors.forename: Wei
authors.initials: W
authors.lastname: Zeng
authors.forename: Qi
authors.initials: Q
authors.lastname: Wang
authors.forename: Fu-Xue
authors.initials: FX
authors.lastname: Chen
mesh_terms: D000447:Aldehydes / Q000737:chemistry*; D002384:Catalysis; D003300:Copper / Q000737:chemistry*; D005459:Fluorides / Q000737:chemistry*; D006845:Hydrocarbons, Fluorinated / Q000737:chemistry*; D015394:Molecular Structure; D010636:Phenols / Q000737:chemistry*; D000644:Quaternary Ammonium Compounds / Q000737:chemistry*; D011802:Quinidine / Q000737:chemistry*
chemical_list: C113796:2-trifluoromethylphenol; D000447:Aldehydes; D006845:Hydrocarbons, Fluorinated; D010636:Phenols; D000644:Quaternary Ammonium Compounds; C057829:copper fluoride; D003300:Copper; D011802:Quinidine; D005459:Fluorides