title: Synthesis and stability of phosphate modified ATP analogues.
abstract: Nucleotides modified at the phosphate have numerous applications. Nevertheless, the number of attachment modes is limited and little is known about their stability. Here, we present results on the elaboration of the synthesis of five classes of ATP analogues and studies concerning their stability. We show that the nitrogen-linked ATP analogue is less stable, whereas the oxygen- and novel carbon-linked adenosine tri- and tetraphosphate analogues are stable from pH 3 to 12 rendering them interesting for further applications and designs.
authors.affiliation: Department of Chemistry and Konstanz Research School of Chemical Biology, Universität Konstanz, Universitätsstrasse 10, 78457 Konstanz, Germany.
authors.forename: Stephan M
authors.initials: SM
authors.lastname: Hacker
authors.forename: Martin
authors.initials: M
authors.lastname: Mex
authors.forename: Andreas
authors.initials: A
authors.lastname: Marx
mesh_terms: D000255:Adenosine Triphosphate / Q000031:analogs & derivatives* / Q000138:chemical synthesis* / Q000737:chemistry*; D015394:Molecular Structure; D009711:Nucleotides / Q000737:chemistry*; D010755:Organophosphates / Q000138:chemical synthesis* / Q000737:chemistry*
chemical_list: D009711:Nucleotides; D010755:Organophosphates; D000255:Adenosine Triphosphate