title: SealBio: A novel, non-obturation endodontic treatment based on concept of regeneration.
abstract: BACKGROUND
  "SealBio", an innovative, non-surgical endodontic treatment protocol, based on "regenerative concept" has been developed to manage pulp and periapically involved teeth.
  
  
  METHODS
  Subsequent to Institute's ethical clearance, 18 patients presenting with signs and symptoms of pulp and periapical disease were included in the study. (11/M, 7/F; Mean age - 44.7 years; range 15-76 years). The protocol included a modified cleaning and shaping technique involving apical clearing and foramen widening, combined with inducing bleeding and clot formation in the apical region. Calcium-sulphate based cement was condensed with hand pluggers into the canal orifices. An appropriate permanent restoration was given. The patients were followed-up clinically and radiographically at regular interval of 6 months. Six teeth in 3 patients were also evaluated pre and post treatment CBCT at 6-months.
  
  
  RESULTS
  The novel treatment protocol was found to be favourable in resolving periapical infection, both clinically and radiographically.
  
  
  CONCLUSIONS
  This innovative endodontic treatment protocol highlights and reiterates the importance of cleaning and shaping and puts forth the possible role of stem cells and growth factors in healing after non-surgical endodontic therapy.
authors.affiliation: Department of Conservative Dentistry and Endodontics and Centre for Dental Education and Research, All India Institute of Medical Sciences, New Delhi, India.
authors.forename: Naseem
authors.initials: N
authors.lastname: Shah
authors.forename: Ajay
authors.initials: A
authors.lastname: Logani
keywords: CBCT; non-obturation Endodontic treatment; periapical healing; regenerative endodontics; sealBio