title: Sonoclot analysis in children with congenital heart disease.
abstract: BACKGROUND
  This study aimed to compare preoperative baseline Sonoclot variables between acyanotic and cyanotic congenital heart disease patients.
  
  
  METHODS
  100 patients aged from infancy to 9-years were studied. Fifty patients each from the cyanotic and acyanotic groups were studied for Sonoclot parameters preoperatively. After inhalational anesthetic induction, blood was collected from the arterial line and analyzed in a Sonoclot analyzer to measure Sonoclot activated coagulation time, clot rate, and platelet function.
  
  
  RESULTS
  Sonoclot activated coagulation time was normal in both groups, but lower in the cyanotic group (127.95 ± 51.4 s) than the acyanotic group (147.85 ± 45.48 s; p = 0.54). Both groups had abnormal clot rates and platelet function. The clot rate was significantly lower in the cyanotic group (19.31 ± 10.68 U·min(-1)) than acyanotic group (24.88 ± 9.23 U·min(-1); p = 0.009). Platelet function was deranged in 31% of patients (cyanotic, 59%; acyanotic, 8%; p <0.001). Platelet function was the most severely affected baseline parameter.
  
  
  CONCLUSIONS
  Pediatric acyanotic and cyanotic congenital heart disease patients have deranged coagulation parameters as assessed by the Sonoclot analyzer. The abnormality is more marked in cyanotic patients. Platelet function is the most severely affected parameter. These baseline parameters in conjunction with post-bypass parameters for an individual patient will help in the formulation of specific blood component transfusion guidelines.
authors.affiliation: Department of Cardiac Anesthesia, All India Institute of Medical Sciences, New Delhi, India. vishaldoc2003@gmail.com
authors.forename: Vishal
authors.initials: V
authors.lastname: Chaudhary
authors.forename: Sandeep
authors.initials: S
authors.lastname: Chauhan
authors.forename: Minati
authors.initials: M
authors.lastname: Choudhury
authors.forename: Usha
authors.initials: U
authors.lastname: Kiran
authors.forename: Sachin
authors.initials: S
authors.lastname: Talwar
authors.forename: Poonam M
authors.initials: PM
authors.lastname: Kapoor
mesh_terms: D001777:Blood Coagulation; D001778:Blood Coagulation Disorders / Q000097:blood / Q000150:complications / Q000175:diagnosis*; D006348:Cardiac Surgical Procedures; D016009:Chi-Square Distribution; D002648:Child; D002675:Child, Preschool; D003490:Cyanosis / Q000097:blood / Q000209:etiology; D004548:Elasticity; D005260:Female; D006330:Heart Defects, Congenital / Q000097:blood* / Q000150:complications / Q000601:surgery; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D010979:Platelet Function Tests; D019095:Point-of-Care Systems; D011237:Predictive Value of Tests; D011446:Prospective Studies; D014783:Viscosity; D014914:Whole Blood Coagulation Time / Q000295:instrumentation*