title: [Prenatal diethylstilbestrol exposure and breast cancer].
abstract: Diethylstilbestrol (DES) is a synthetic estrogen prescribed to prevent miscarriages until 1977. Its role in the development of vaginal adenocarcinoma and cervical dysplasia is known and screening codified. Recent cohort studies show that exposure to DES in utero increases breast cancer risk especially after 40 years. This article reports the observation of a breast cancer of exceptional gravity in a patient exposed to DES in utero. It details the risk of breast cancer for "DES daughters" and support possible screening modalities.
authors.affiliation: Unité de sénologie, pôle de gynécologie-obstétrique, CHRU de Strasbourg, avenue Molière, 67200 Strasbourg cedex, France. severine.frigo@chru-strasbourg.fr
authors.forename: S
authors.initials: S
authors.lastname: Frigo
authors.forename: C
authors.initials: C
authors.lastname: Malina
authors.forename: C
authors.initials: C
authors.lastname: Mathelin
mesh_terms: D001943:Breast Neoplasms / Q000139:chemically induced* / Q000601:surgery; D002285:Carcinoma, Intraductal, Noninfiltrating / Q000139:chemically induced / Q000601:surgery; D004054:Diethylstilbestrol / Q000009:adverse effects*; D005260:Female; D006801:Humans; D008408:Mastectomy; D008875:Middle Aged; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects
chemical_list: D004054:Diethylstilbestrol