title: Intracellular cholestasis in HCV and HBV infection.
abstract: Structural analysis of hepatocytes in liver biopsy specimens from patients with hepatitis C and C+B with intracellular cholestasis was carried out. Large foci of bile components in hepatocytes led to cell damage, eventuating in cell destruction and death. The cholestatic variant of mixed infection was characterized by destructive necrotic changes in hepatocytes and progressive fibrosis of the liver. Destruction of the hepatocyte cytoplasmic organelles was associated with high activity of the infectious process and pronounced cytolytic syndrome.
authors.affiliation: Institute of Regional Pathology and Pathomorphology, Siberian Division of the Russian Academy of Medical Sciences, Novosibirsk, Russia. pathol@soramn.ru
authors.forename: O A
authors.initials: OA
authors.lastname: Postnikova
authors.forename: G I
authors.initials: GI
authors.lastname: Nepomnyashchikh
authors.forename: A V
authors.initials: AV
authors.lastname: Yudanov
authors.forename: D L
authors.initials: DL
authors.lastname: Nepomnyashchikh
authors.forename: V I
authors.initials: VI
authors.lastname: Kapustina
authors.forename: V I
authors.initials: VI
authors.lastname: Isayenko
mesh_terms: D001652:Bile Ducts / Q000473:pathology* / Q000821:virology; D001706:Biopsy; D016923:Cell Death; D002779:Cholestasis / Q000150:complications / Q000473:pathology* / Q000821:virology; D060085:Coinfection; D005260:Female; D005355:Fibrosis; D016174:Hepacivirus; D006515:Hepatitis B virus; D019694:Hepatitis B, Chronic / Q000150:complications / Q000473:pathology* / Q000821:virology; D019698:Hepatitis C, Chronic / Q000150:complications / Q000473:pathology* / Q000821:virology; D022781:Hepatocytes / Q000473:pathology* / Q000821:virology; D006801:Humans; D008099:Liver / Q000473:pathology* / Q000821:virology; D008297:Male; D012720:Severity of Illness Index