title: Hyaluronic Acid as an adjunct after scaling and root planing: a prospective randomized clinical trial.
abstract: BACKGROUND
  The study is designed to determine the effect on clinical variables, subgingival bacteria, and local immune response brought about by application of hyaluronan-containing gels in early wound healing after scaling and root planing (SRP).
  
  
  METHODS
  In this randomized clinical study, data from 34 individuals with chronic periodontitis were evaluated after full-mouth SRP. In the test group (n = 17), hyaluronan gels in two molecular weights were additionally applied during the first 2 weeks after SRP. The control group (n = 17) was treated with SRP only. Probing depth (PD) and clinical attachment level (CAL) were recorded at baseline and after 3 and 6 months, and subgingival plaque and sulcus fluid samples were taken for microbiologic and biochemical analysis.
  
  
  RESULTS
  In both groups, PD and CAL were significantly reduced (P <0.001). The changes in PD and the reduction of the number of pockets with PD ≥5 mm were significantly higher in the test group after 3 (P = 0.014 and 0.021) and 6 (P = 0.046 and 0.045) months. Six months after SRP, the counts of Treponema denticola were significantly reduced in both groups (both P = 0.043), as were those of Campylobacter rectus in the test group only (P = 0.028). Prevotella intermedia and Porphyromonas gingivalis increased in the control group.
  
  
  CONCLUSIONS
  The adjunctive application of hyaluronan may have positive effects on PD reduction and may prevent recolonization by periodontopathogens.
authors.affiliation: Department of Periodontology, Laboratory of Oral Microbiology, Dental School, University of Bern, Bern, Switzerland.
authors.forename: Sigrun
authors.initials: S
authors.lastname: Eick
authors.forename: Antonio
authors.initials: A
authors.lastname: Renatus
authors.forename: Melanie
authors.initials: M
authors.lastname: Heinicke
authors.forename: Wolfgang
authors.initials: W
authors.lastname: Pfister
authors.forename: Stefan-Ioan
authors.initials: SI
authors.lastname: Stratul
authors.forename: Holger
authors.initials: H
authors.lastname: Jentsch
mesh_terms: D000328:Adult; D000368:Aged; D016976:Aggregatibacter actinomycetemcomitans / Q000187:drug effects; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D058491:Bacterial Load / Q000187:drug effects; D001439:Bacteroides / Q000187:drug effects; D044883:Campylobacter rectus / Q000187:drug effects; D055113:Chronic Periodontitis / Q000382:microbiology / Q000628:therapy*; D003773:Dental Plaque / Q000737:chemistry / Q000382:microbiology; D012534:Dental Scaling / Q000379:methods*; D005260:Female; D005500:Follow-Up Studies; D005782:Gels; D005883:Gingival Crevicular Fluid / Q000737:chemistry / Q000382:microbiology; D006801:Humans; D006820:Hyaluronic Acid / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D008970:Molecular Weight; D017622:Periodontal Attachment Loss / Q000382:microbiology / Q000628:therapy; D010514:Periodontal Pocket / Q000382:microbiology / Q000628:therapy; D016966:Porphyromonas gingivalis / Q000187:drug effects; D018713:Prevotella intermedia / Q000187:drug effects; D011446:Prospective Studies; D016745:Root Planing / Q000379:methods*; D048373:Treponema denticola / Q000187:drug effects; D055675:Viscosupplements / Q000627:therapeutic use*; D014945:Wound Healing / Q000502:physiology
chemical_list: D000900:Anti-Bacterial Agents; D005782:Gels; D055675:Viscosupplements; D006820:Hyaluronic Acid