title: Urinary levels of 8-iso-prostaglandin f2α and 8-hydroxydeoxyguanine as markers of oxidative stress in patients with coronary artery disease.
abstract: OBJECTIVE
  The objective of this study was to determine if urinary levels of 8-iso-prostaglandin F2α (8-iso-PGF2α) and 8-hydroxydeoxyguanine (8-OHdG) could be used as markers of the oxidative stress in significant coronary artery disease (CAD).
  
  
  METHODS
  We conducted a case-control study in 104 subjects assessed by coronary angiography with the following diagnoses: 35 consecutive cases of significant CAD and 69 cases of non-CAD with stable angina. We compared the urinary levels of 8-iso-PGF 2α and 8-OHdG, as measured by immunoassay between the 2 groups.
  
  
  RESULTS
  History of hypertension was significantly higher and high density lipoprotein-cholesterol level significantly lower in the CAD group compared with those in the non-CAD group. Median levels of 8-iso-PGF2α were significantly higher in the CAD group compared with the non-CAD group (9.2 vs. 6.0 ng/mg, p=0.001). There were no significant differences in 8-OHdG values between the 2 groups. The odds ratio of 8-iso-PGF2α for CAD in the highest tertile compared with that in the lowest tertile was 7.39 (95% confidence interval; 1.71-31.91). There was no significant difference in median values of 8-iso-PGF2α between single- and multi-vessel CAD.
  
  
  CONCLUSIONS
  Urinary 8-iso-PGF 2α was independently associated with significant CAD in this case-control study.
authors.affiliation: Division of Cardiology, Department of Internal Medicine, Wonju College of Medicine, Yonsei University, Wonju, Korea.
authors.forename: Jang-Young
authors.initials: JY
authors.lastname: Kim
authors.forename: Jun-Won
authors.initials: JW
authors.lastname: Lee
authors.forename: Young-Jin
authors.initials: YJ
authors.lastname: Youn
authors.forename: Min-Soo
authors.initials: MS
authors.lastname: Ahn
authors.forename: Sung-Gyun
authors.initials: SG
authors.lastname: Ahn
authors.forename: Byung-Su
authors.initials: BS
authors.lastname: Yoo
authors.forename: Seung-Hwan
authors.initials: SH
authors.lastname: Lee
authors.forename: Junghan
authors.initials: J
authors.lastname: Yoon
authors.forename: Kyung-Hoon
authors.initials: KH
authors.lastname: Choe
keywords: Coronary artery disease; Oxidative stress