title: Effect of tissue-engineered chitosan-poly(vinyl alcohol) nanofibrous scaffolds on healing of burn wounds of rat skin.
abstract: Chitosan-poly(vinyl alcohol) (Cs:PVA) nanofibrous scaffolds were electrospun from 2:3 (wt/wt) Cs:PVA solution dissolved in 80% acetic acid. In vivo study was carried out on the dorsum skin of rat which burnt with a hot brass cylinder. The scaffolds were applied in two forms, that is, acellular (n=6) and cell-seeded with mesenchymal stem cells (n=6). Macroscopic measurements of wound area showed good aspect healing effect of scaffolds in comparison with control wounds specially in 15 days post operating. Pathological studies were done on the wounds to investigate the healing effects. The healing process of the wound covered with Cs/PVA nanofibrous scaffolds was much rapid compared to untreated wounds. However, the presence of stem cells on this scaffolds accelerated the wound healing process owing to their ability of collagen regeneration.
authors.affiliation: Amirkabir University of Technology, Textile Engineering Department, Tehran, Iran.
authors.forename: A
authors.initials: A
authors.lastname: Gholipour-Kanani
authors.forename: S H
authors.initials: SH
authors.lastname: Bahrami
authors.forename: A
authors.initials: A
authors.lastname: Samadi-Kochaksaraie
authors.forename: H
authors.initials: H
authors.lastname: Ahmadi-Tafti
authors.forename: S
authors.initials: S
authors.lastname: Rabbani
authors.forename: A
authors.initials: A
authors.lastname: Kororian
authors.forename: E
authors.initials: E
authors.lastname: Erfani
mesh_terms: D000818:Animals; D001458:Bandages; D002056:Burns / Q000473:pathology / Q000628:therapy*; D048271:Chitosan / Q000737:chemistry* / Q000627:therapeutic use; D062109:Dermatologic Surgical Procedures / Q000379:methods; D004867:Equipment Design; D019544:Equipment Failure Analysis; D008297:Male; D049329:Nanostructures / Q000737:chemistry* / Q000627:therapeutic use; D011142:Polyvinyl Alcohol / Q000737:chemistry / Q000627:therapeutic use; D051381:Rats; D017207:Rats, Sprague-Dawley; D012867:Skin / Q000293:injuries* / Q000473:pathology; D033581:Stem Cell Transplantation / Q000295:instrumentation*; D023822:Tissue Engineering / Q000295:instrumentation*; D054457:Tissue Scaffolds; D016896:Treatment Outcome
chemical_list: D011142:Polyvinyl Alcohol; D048271:Chitosan