title: Inflammation, wound repair, and fibrosis: reassessing the spectrum of tissue injury and resolution.
abstract: Estimates from various disease-specific registries suggest that chronic inflammatory and fibrotic disorders affect a large proportion of the world's population, yet therapies for these conditions are largely ineffective. Recent advances in our collective understanding of mechanisms underlying both physiological and pathological repair of tissue injury are informing new clinical approaches to deal with various human inflammatory and fibrotic diseases. This 2013 Annual Review Issue of The Journal of Pathology offers an up-to-date glimpse of ongoing research in the fields of inflammation, wound healing, and tissue fibrosis, and highlights novel pathways and mechanisms that may be exploited to provide newer, more effective treatments to patients worldwide suffering from these conditions.
authors.affiliation: Department of Internal Medicine, Division of Pulmonary and Critical Care Medicine, University of Michigan, 1150 W Medical Center Drive, 6301 MSRB III SPC 5642, Ann Arbor, MI, 48109, USA. docew@med.umich.edu
authors.forename: Eric S
authors.initials: ES
authors.lastname: White
authors.forename: Alberto R
authors.initials: AR
authors.lastname: Mantovani
mesh_terms: D000818:Animals; D005109:Extracellular Matrix / Q000378:metabolism / Q000473:pathology; D005355:Fibrosis; D005786:Gene Expression Regulation; D020022:Genetic Predisposition to Disease; D006801:Humans; D007249:Inflammation / Q000235:genetics / Q000276:immunology / Q000378:metabolism / Q000473:pathology* / Q000517:prevention & control; D018836:Inflammation Mediators / Q000378:metabolism; D015398:Signal Transduction; D014945:Wound Healing
chemical_list: D018836:Inflammation Mediators