title: Visual outcome correlates with inner macular volume in eyes with surgically closed macular hole.
abstract: OBJECTIVE
  To determine the macular morphologic features that correlate best with visual outcome in eyes with surgically closed idiopathic macular hole.
  
  
  METHODS
  Transversal observational case series of 24 eyes (22 subjects) imaged postoperatively using high-resolution Fourier domain optical coherence tomography (FD-OCT). Total and inner macular volume for central 3 mm area, central foveal thickness, and size of foveal inner segment-outer segment junction abnormality were correlated with best-corrected visual acuity. Microperimetry (MP-1) test was performed in a subset of 18 eyes.
  
  
  RESULTS
  Mean postoperative best-corrected visual acuity was 20/36 (range, 20/25-20/70). Postoperative follow-up mean was 32.97 ± 24.68 months (range, 5-96 months). Eighteen eyes underwent internal limiting membrane (ILM) peeling. Among FD-OCT parameters, logarithm of the minimum angle of resolution best-corrected visual acuity and mean total microperimetry-1 sensitivity correlated best with inner macular volume in all eyes and ILM-peeled eyes (P < 0.05). Macular surface irregularities were noted in 12 eyes (66.7%) with ILM peeling but in none of the non-ILM-peeled eyes (P = 0.02). No significant correlation was found between microperimetry-1 sensitivity and other FD-OCT parameters.
  
  
  CONCLUSIONS
  Because inner macular volume strongly correlated with visual outcome in eyes with surgically closed macular hole, the possible effect of ILM peeling on visual outcome needs to be further investigated.
authors.affiliation: Department of Ophthalmology and Vision Science, University of California Davis Eye Center, Sacramento, California, USA.
authors.forename: Suman
authors.initials: S
authors.lastname: Pilli
authors.forename: Robert J
authors.initials: RJ
authors.lastname: Zawadzki
authors.forename: John S
authors.initials: JS
authors.lastname: Werner
authors.forename: Susanna S
authors.initials: SS
authors.lastname: Park
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001485:Basement Membrane / Q000601:surgery; D058450:Endotamponade; D005260:Female; D005500:Follow-Up Studies; D005583:Fourier Analysis; D006801:Humans; D008266:Macula Lutea / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D016684:Prone Position; D012167:Retinal Perforations / Q000503:physiopathology / Q000601:surgery*; D055211:Retinal Photoreceptor Cell Inner Segment / Q000473:pathology; D055214:Retinal Photoreceptor Cell Outer Segment / Q000473:pathology; D041623:Tomography, Optical Coherence; D016896:Treatment Outcome; D014792:Visual Acuity / Q000502:physiology*; D058609:Visual Field Tests; D014821:Vitrectomy