title: Disordered cardiovascular control after spinal cord injury.
abstract: Damage to the spinal cord disrupts autonomic pathways, perturbing cardiovascular homeostasis. Cardiovascular dysfunction increases with higher levels of injury and greater severity. Disordered blood pressure control after spinal cord injury (SCI) has significant ramifications as cord-injured people have an increased risk of developing heart disease and stroke; cardiovascular dysfunction is currently a leading cause of death among those with SCI. Despite the clinical significance of abnormal cardiovascular control following SCI, this problem has been generally neglected by both the clinical and research community. Both autonomic dysreflexia and orthostatic hypotension are known to prevent and delay rehabilitation, and significantly impair the overall quality of life after SCI. Starting with neurogenic shock immediately after a higher SCI, ensuing cardiovascular dysfunctions include orthostatic hypotension, autonomic dysreflexia and cardiac arrhythmias. Disordered temperature regulation accompanies these autonomic dysfunctions. This chapter reviews the human and animal studies that have furthered our understanding of the pathophysiology and mechanisms of orthostatic hypotension, autonomic dysreflexia and cardiac arrhythmias. The cardiovascular dysfunction that occurs during sexual function and exercise is elaborated. New awareness of cardiovascular dysfunction after SCI has led to progress toward inclusion of this important autonomic problem in the overall assessment of the neurological condition of cord-injured people.
authors.affiliation: University of Western Ontario, London, Ontario, Canada. lcweaver@robarts.ca
authors.forename: Lynne C
authors.initials: LC
authors.lastname: Weaver
authors.forename: Jennifer C
authors.initials: JC
authors.lastname: Fleming
authors.forename: Christopher J
authors.initials: CJ
authors.lastname: Mathias
authors.forename: Andrei V
authors.initials: AV
authors.lastname: Krassioukov
mesh_terms: D001342:Autonomic Nervous System Diseases / Q000209:etiology; D001794:Blood Pressure / Q000502:physiology; D001833:Body Temperature Regulation; D002318:Cardiovascular Diseases / Q000209:etiology*; D006339:Heart Rate / Q000502:physiology; D006801:Humans; D013119:Spinal Cord Injuries / Q000150:complications*