title: Griseusins F and G, spiro-naphthoquinones from a tin mine tailings-derived alkalophilic Nocardiopsis species.
abstract: Griseusins F (1) and G (2), two 2a-hydro-8a-(2-oxopropyl)-substituted spiro-naphthoquinones with a previously undescribed C23 polyketide skeleton, were isolated from a Yunnan tin mine tailings-derived alkalophilic actinomycete, Nocardiopsis sp. YIM DT266. Their complete structure assignments with the absolute stereochemistry were elucidated by spectroscopic data, X-ray crystal diffraction, calculation of optical rotation, and CD spectroscopic analysis. Compounds 1 and 2 exhibited strong cytotoxicity (IC50 0.37-0.82 μM) and antibacterial activity (MIC 0.80-1.65 μg/mL) against Gram-positive bacteria, including methicillin-resistant Staphylococcus aureus (MRSA) in vitro.
authors.affiliation: Key Laboratory for Microbial Resources, Key Laboratory of Medicinal Chemistry for Natural Resources, Ministry of Education, Yunnan Institute of Microbiology, Yunnan University , Kunming, 650091, People's Republic of China.
authors.forename: Zhang-Gui
authors.initials: ZG
authors.lastname: Ding
authors.forename: Jiang-Yuan
authors.initials: JY
authors.lastname: Zhao
authors.forename: Ming-Gang
authors.initials: MG
authors.lastname: Li
authors.forename: Rong
authors.initials: R
authors.lastname: Huang
authors.forename: Qing-Ming
authors.initials: QM
authors.lastname: Li
authors.forename: Xiao-Long
authors.initials: XL
authors.lastname: Cui
authors.forename: Hua-Jie
authors.initials: HJ
authors.lastname: Zhu
authors.forename: Meng-Liang
authors.initials: ML
authors.lastname: Wen
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D006094:Gram-Positive Bacteria; D045325:HCT116 Cells; D006801:Humans; D055624:Methicillin-Resistant Staphylococcus aureus; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D009285:Naphthoquinones / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D009615:Nocardia / Q000737:chemistry*
chemical_list: D000900:Anti-Bacterial Agents; D009285:Naphthoquinones; C012339:griseusin