title: A malfunction in triglyceride transfer from the intracellular lipid pool to apoB in enterocytes of SOD1-deficient mice.
abstract: We compared lipid metabolism in the intestines of Sod1-knockout mice with that found in wild-type mice to elucidate the impact of oxidative stress in vivo. A high-fat diet in wild-type mice induced postprandial hypertriglyceridemia, but this adaptive response was impaired in Sod1-knockout mice. While fewer triglycerides were secreted to the blood in the form of triglyceride-rich lipoprotein, more lipid droplets accumulated in the enterocytes of Sod1-knockout mice fed a high-fat diet. These data collectively suggest that high-fat diet induces oxidative stress, inhibits lipid secretion to the blood, and ultimately leads to dysfunctional lipid metabolism in enterocytes.
authors.affiliation: Department of Biochemistry and Molecular Biology, Graduate School of Medical Science, Yamagata University, 2-2-2 Iidanishi, Yamagata 990-9585, Japan.
authors.forename: Toshihiro
authors.initials: T
authors.lastname: Kurahashi
authors.forename: Tasuku
authors.initials: T
authors.lastname: Konno
authors.forename: Noriyuki
authors.initials: N
authors.lastname: Otsuki
authors.forename: Myoungsu
authors.initials: M
authors.lastname: Kwon
authors.forename: Satoshi
authors.initials: S
authors.lastname: Tsunoda
authors.forename: Junitsu
authors.initials: J
authors.lastname: Ito
authors.forename: Junichi
authors.initials: J
authors.lastname: Fujii
mesh_terms: D000818:Animals; D001055:Apolipoproteins B / Q000378:metabolism*; D059305:Diet, High-Fat / Q000009:adverse effects; D020895:Enterocytes / Q000378:metabolism*; D015228:Hypertriglyceridemia / Q000378:metabolism; D007408:Intestinal Absorption / Q000502:physiology; D050356:Lipid Metabolism; D008074:Lipoproteins / Q000378:metabolism; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D018345:Mice, Knockout; D013482:Superoxide Dismutase / Q000235:genetics / Q000378:metabolism*; D000072105:Superoxide Dismutase-1; D014280:Triglycerides / Q000097:blood / Q000378:metabolism*
chemical_list: D001055:Apolipoproteins B; D008074:Lipoproteins; D014280:Triglycerides; C030087:lipoprotein triglyceride; C000606291:Sod1 protein, mouse; D013482:Superoxide Dismutase; D000072105:Superoxide Dismutase-1