title: [Artificial selection for cattle based on high-density SNP markers].
abstract: With the implementation of genetic improvement in recent years, artificial selection has greatly improved beef cattle production performance and its genetic basis has been dramatically changed. In this study, based on the Illumina BovineSNP50 (54K) and BovineHD (770K) BeadChip and the FST value, we analyzed the genetic differentiation of cattle and screened the imprints of selection in bovine genome. Finally, we found 47104 OUTLIER SNP loci and 3064 candidate genes, for example, CLIC5, TG, CACNA2D1, and FSHR etc. The biological processes and molecular functions of genes were analyzed through gene annotation.The results of this study established a genome-wide map of selection footprints in beef cattle genome and a clue for in-depth study of artificial selection and understanding of biological evolution.Our results indicate that artificial selection has played an important role in cattle breed genetic improvement.
authors.affiliation: Key Laboratory of Farm Animal Genetic Resources and Utilization of Ministry of Agriculture, Beef Cattle Research Center, Institute of Animal Sciences, Chinese Academy of Agricultural Sciences, Beijing 100193, China. liuxdchn@gmail.com
authors.forename: Xi-Dong
authors.initials: XD
authors.lastname: Liu
authors.forename: Zhi-Peng
authors.initials: ZP
authors.lastname: Wang
authors.forename: Hui-Zhong
authors.initials: HZ
authors.lastname: Fan
authors.forename: Jun-Ya
authors.initials: JY
authors.lastname: Li
authors.forename: Hui-Jiang
authors.initials: HJ
authors.lastname: Gao
mesh_terms: D000818:Animals; D001947:Breeding; D002417:Cattle / Q000235:genetics*; D005819:Genetic Markers; D020641:Polymorphism, Single Nucleotide
chemical_list: D005819:Genetic Markers