title: Interaction of platelets and anidulafungin against Aspergillus fumigatus.
abstract: The combination of platelets and anidulafungin at 0.03 μg/ml significantly (P < 0.05) reduced the germination rate and hyphal elongation in Aspergillus fumigatus compared to those with either anidulafungin only or an untreated control. Platelets decreased the expression of the fks gene, which plays an important role in cell wall synthesis. Our results suggest that human platelets plus anidulafungin might contribute to defense against A. fumigatus.
authors.affiliation: University of Applied Sciences Tyrol, Innsbruck, Austria. Susanne.Perkhofer@fhg-tirol.ac.at
authors.forename: Susanne
authors.initials: S
authors.lastname: Perkhofer
authors.forename: Barbara
authors.initials: B
authors.lastname: Striessnig
authors.forename: Bettina
authors.initials: B
authors.lastname: Sartori
authors.forename: Barbara
authors.initials: B
authors.lastname: Hausott
authors.forename: Helmut W
authors.initials: HW
authors.lastname: Ott
authors.forename: Cornelia
authors.initials: C
authors.lastname: Lass-Flörl
mesh_terms: D000077612:Anidulafungin; D000935:Antifungal Agents / Q000378:metabolism / Q000494:pharmacology*; D001232:Aspergillus fumigatus / Q000187:drug effects* / Q000254:growth & development / Q000302:isolation & purification; D001792:Blood Platelets / Q000166:cytology / Q000378:metabolism*; D018929:Cell Culture Techniques; D054714:Echinocandins / Q000378:metabolism / Q000494:pharmacology*; D005656:Fungal Proteins / Q000235:genetics*; D015870:Gene Expression / Q000187:drug effects; D005964:Glucosyltransferases / Q000235:genetics*; D006801:Humans; D025301:Hyphae / Q000187:drug effects* / Q000254:growth & development; D055744:Invasive Pulmonary Aspergillosis / Q000382:microbiology; D008826:Microbial Sensitivity Tests
chemical_list: D000935:Antifungal Agents; D054714:Echinocandins; D005656:Fungal Proteins; D000077612:Anidulafungin; D005964:Glucosyltransferases