title: Miscibility of eudragit/chitosan polymer blend in water determined by physical property measurements.
abstract: The interest in the preparation and application of polymeric blends is growing since they can exhibit properties of great industrial interest. The current study focuses on the preparation of polymeric blends of varying compositions of eudragit and chitosan and their miscibility studies. The preparation was carried out by using ethanol and 1% acetic acid in water. FT-IR spectra reveal the possibilities of chemical interactions between eudragit/chitosan. The miscibility of polymeric blend at different composition has been investigated by viscosity, ultrasonic velocity, density, refractive index and adiabatic compressibility values measured at two different temperatures 30 °C and 40 °C. The interaction parameters ΔB, μ and α, were determined from viscosity data. From the values observed, it is found that the blend is miscible in all compositions at 30 °C whereas at 40 °C, it seems to be immiscible in certain compositions. It is found that the blend is miscible, when the chitosan concentration is more than 70% (v/v) at both the temperatures and also observed that variation of temperature has no effect on the miscibility of eudragit/chitosan blend.
authors.affiliation: Materials Chemistry Division, Centre for Excellence in Nanomaterials, School of Advanced Sciences, VIT University, Vellore 632014, Tamil Nadu, India.
authors.forename: Sk Ershadul
authors.initials: SE
authors.lastname: Haque
authors.forename: A
authors.initials: A
authors.lastname: Sheela
mesh_terms: D019342:Acetic Acid / Q000737:chemistry; D048271:Chitosan / Q000737:chemistry*; D004337:Drug Carriers / Q000737:chemistry*; D000431:Ethanol / Q000737:chemistry; D011109:Polymethacrylic Acids / Q000737:chemistry*; D017550:Spectroscopy, Fourier Transform Infrared; D013696:Temperature; D014783:Viscosity; D014867:Water / Q000737:chemistry
chemical_list: D004337:Drug Carriers; C496966:Eudragit RSPO; D011109:Polymethacrylic Acids; D014867:Water; D000431:Ethanol; D048271:Chitosan; D019342:Acetic Acid