title: Vectors for inhaled gene therapy in lung cancer. Application for nano oncology and safety of bio nanotechnology.
abstract: Novel aerosol therapeutic modalities have been investigated for lung cancer. Inhaled gene therapy has presented safety and effectiveness previously in cystic fibrosis. However, safety concerns have been raised regarding the safety of non-viral vectors for inhaled gene therapy in lung cancer, and therefore small steps have been made towards this multifunctional treatment modality. During the last decade, numerous new nanocomplexes have been created and investigated as a safe gene delivery nano-vehicle. These formulations are multifunctional; they can be used as either local therapy or carrier for an effective inhaled gene therapy for lung cancer. Herein, we present current and future perspectives of nanocomplexes for inhaled gene therapy treatment in lung cancer.
authors.affiliation: Pulmonary Department-Oncology Unit, "G. Papanikolaou" General Hospital, Aristotle University of Thessaloniki, Thessaloniki 57010, Greece.|Pulmonary Department-Interventional Unit, "Ruhrland Klinik", University of Essen, Essen 45239, Germany.
authors.forename: Paul
authors.identifier: 0000-0001-5119-2207
authors.initials: P
authors.lastname: Zarogouldis
authors.affiliation: Laboratory of Biochemistry, University of Patras, Patras 25200, Greece.
authors.forename: Nikos K
authors.initials: NK
authors.lastname: Karamanos
authors.affiliation: Pulmonary Department-Oncology Unit, "G. Papanikolaou" General Hospital, Aristotle University of Thessaloniki, Thessaloniki 57010, Greece.
authors.forename: Konstantinos
authors.identifier: 0000-0001-7215-2191
authors.initials: K
authors.lastname: Porpodis
authors.affiliation: Pulmonary Department-Oncology Unit, "G. Papanikolaou" General Hospital, Aristotle University of Thessaloniki, Thessaloniki 57010, Greece.
authors.forename: Kalliopi
authors.initials: K
authors.lastname: Domvri
authors.affiliation: Department of Respiratory diseases, Changhai hospital, Second Military Medical University, Shanghai 200433, China.
authors.forename: Haidong
authors.initials: H
authors.lastname: Huang
authors.affiliation: II Medical Clinic, Hospital of Coburg, University of Wurzburg, Coburg 96450, Germany.
authors.forename: Wolfgang
authors.initials: W
authors.lastname: Hohenforst-Schimdt
authors.affiliation: Biomaterials Science & Engineering, Department of Materials Science & Engineering, University of Florida, FL 32611, USA.
authors.forename: Eugene P
authors.initials: EP
authors.lastname: Goldberg
authors.affiliation: Pulmonary Department-Oncology Unit, "G. Papanikolaou" General Hospital, Aristotle University of Thessaloniki, Thessaloniki 57010, Greece.
authors.forename: Konstantinos
authors.initials: K
authors.lastname: Zarogoulidis
mesh_terms: D000280:Administration, Inhalation; D000336:Aerosols / Q000008:administration & dosage / Q000627:therapeutic use; D000818:Animals; D018014:Gene Transfer Techniques; D015316:Genetic Therapy / Q000379:methods*; D005822:Genetic Vectors / Q000008:administration & dosage* / Q000235:genetics / Q000627:therapeutic use; D006801:Humans; D008168:Lung / Q000473:pathology; D008175:Lung Neoplasms / Q000235:genetics / Q000473:pathology / Q000628:therapy*; D050997:Nanomedicine / Q000379:methods; D036103:Nanotechnology / Q000379:methods
chemical_list: D000336:Aerosols
keywords: inhaled gene therapy; lung cancer; nanobiotechnology; nanocomplexes; non-viral vectors