title: Direct synthesis of sensitive selenocysteine peptides by the Ugi reaction.
abstract: Ammonia and selenoaldehydes are both problematic components in Ugi reactions. Here we report the efficient direct multicomponent synthesis of sensitive selenocysteine peptides without the use of convertible (protected) primary amines, including suitable deprotection protocols for selenols.
authors.affiliation: Leibniz-Institut für Pflanzenbiochemie, Weinberg 3, D-06120 Halle (Saale), Germany.
authors.forename: Muhammad
authors.initials: M
authors.lastname: Abbas
authors.forename: Ludger A
authors.initials: LA
authors.lastname: Wessjohann
mesh_terms: D002254:Carbonates / Q000737:chemistry; D015394:Molecular Structure; D010455:Peptides / Q000138:chemical synthesis*; D017279:Selenocysteine / Q000138:chemical synthesis*; D014270:Trifluoroethanol / Q000737:chemistry
chemical_list: D002254:Carbonates; D010455:Peptides; D017279:Selenocysteine; D014270:Trifluoroethanol; C040502:ammonium carbonate