title: Thoracoscopic resection for a pulmonary nodule with the infiltrate of IgG4-positive plasma cells.
abstract: This report describes a rare case of IgG4-related lung disease that was difficult to distinguish from lung cancer. CT revealed a well-demarcated round tumor in S10 of the right lung of a 56-year-old man suspected of having lung cancer. PET revealed high fluorodeoxyglucose uptake with a maximum standardized uptake value of 14.0. Because primary lung cancer was strongly suspected, lower lobectomy was performed via the thoracoscopic approach without mini-thoracotomy. Histopathology showed lymphoplasmacytic infiltration. Immunostaining revealed numerous IgG4-positive plasma cells diffusely infiltrating the tumor. Serum IgG4 levels increased, thereby confirming the diagnosis of IgG4-related lung disease.
authors.affiliation: Department of Surgery, Jikei University School of Medicine, Tokyo, Japan. mak@jikei.ac.jp
authors.forename: Makoto
authors.initials: M
authors.lastname: Odaka
authors.forename: Shohei
authors.initials: S
authors.lastname: Mori
authors.forename: Hisatoshi
authors.initials: H
authors.lastname: Asano
authors.forename: Makoto
authors.initials: M
authors.lastname: Yamashita
authors.forename: Noriki
authors.initials: N
authors.lastname: Kamiya
authors.forename: Toshiaki
authors.initials: T
authors.lastname: Morikawa
mesh_terms: D003937:Diagnosis, Differential; D006801:Humans; D007074:Immunoglobulin G / Q000032:analysis*; D008175:Lung Neoplasms / Q000175:diagnosis*; D008297:Male; D008875:Middle Aged; D010950:Plasma Cells / Q000473:pathology*; D011013:Pneumonectomy; D049268:Positron-Emission Tomography; D003074:Solitary Pulmonary Nodule / Q000175:diagnosis / Q000473:pathology / Q000601:surgery*; D013906:Thoracoscopy
chemical_list: D007074:Immunoglobulin G