title: Gassman's cationic [2 + 2] cycloadditions using temporary tethers.
abstract: An intermolecular equivalent of Gassman's cationic [2 + 2] cycloaddition through the use of temporary tethering is described. Notably, hydrazine and hydroxyamide proved to be robust under the acidic conditions required for the cycloaddition, leading to unique cyclobutane manifolds in a highly regio- and stereoselective manner. This development represents a rare usage of hydrazine and hydroxyamide in the capacity as temporary tethers.
authors.affiliation: Division of Pharmaceutical Sciences and Department of Chemistry, Rennebohm Hall, 777 Highland Avenue, University of Wisconsin, Madison, Wisconsin 53705-2222, USA.
authors.forename: Jun
authors.initials: J
authors.lastname: Deng
authors.forename: Richard P
authors.initials: RP
authors.lastname: Hsung
authors.forename: Changhong
authors.initials: C
authors.lastname: Ko
mesh_terms: D000577:Amides / Q000737:chemistry*; D003500:Cyclization; D061565:Cycloaddition Reaction; D006834:Hydrazines / Q000737:chemistry*; D015394:Molecular Structure; D013237:Stereoisomerism
chemical_list: D000577:Amides; D006834:Hydrazines