title: Boolean versus continuous dynamics in modules with two feedback loops.
abstract: We investigate the dynamical behavior of simple networks, namely loops with an additional internal regulating connection. Continuous dynamics for mRNA and protein concentrations is compared to a Boolean model for gene activity. Using a generalized method and within a single framework, we study different continuous models and different types of regulatory functions, and establish conditions under which the system can display stable oscillations or stable fixed points. These conditions depend only on general features such as the degree of cooperativity of the regulating interactions and the logical structure of the interactions. There are no simple rules for deciding when Boolean and continuous dynamics agree with each other, but we identify several relevant criteria.
authors.affiliation: Institut für Festkörperphysik, TU Darmstadt, Hochschulstraße 6, 64289, Darmstadt, Germany. evachr@fkp.tu-darmstadt.de
authors.forename: Eva
authors.initials: E
authors.lastname: Ackermann
authors.forename: Eva Marie
authors.initials: EM
authors.lastname: Weiel
authors.forename: Torsten
authors.initials: T
authors.lastname: Pfaff
authors.forename: Barbara
authors.initials: B
authors.lastname: Drossel
mesh_terms: D025461:Feedback, Physiological; D005786:Gene Expression Regulation; D008954:Models, Biological; D011506:Proteins / Q000378:metabolism; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism
chemical_list: D011506:Proteins; D012333:RNA, Messenger