title: Diagnostic strategies for subclinical hypothyroidism.
abstract: The aim of this study is to delineate laboratory diagnostic strategies for subclinical hypothyroidism in patients who are clinically symptomatic but may have a normal thyroid profile. Tri - iodothyronine (T(3)), thyroxine (T(4)), thyroid stimulating hormone (TSH) and anti thyroid peroxidase antibodies (anti-TPO) were estimated on fasting blood samples from 99 patients using electrochemiluminescence methods on ELECSYS 1010 (Roche). 74% of study subjects had elevated anti-TPO levels.61% patients had subclinical hypothyroidism. 45 of the 61 subclinical hypothyroid patients had elevated anti-TPO levels (73%). This is an important finding suggesting an autoimmune etiology for subclinical thyroid dysfunction with a higher risk of developing overt hypothyroidism.
authors.affiliation: Department of Biochemistry, Kamineni Institute of Medical Sciences, Narkatpally, Nalgonda District A.P. 508 254 India.
authors.forename: Shruti
authors.initials: S
authors.lastname: Mohanty
authors.forename: W
authors.initials: W
authors.lastname: Amruthlal
authors.forename: G C
authors.initials: GC
authors.lastname: Reddy
authors.forename: G
authors.initials: G
authors.lastname: Kusumanjali
authors.forename: A S
authors.initials: AS
authors.lastname: Kanagasabapathy
authors.forename: Pragna
authors.initials: P
authors.lastname: Rao
keywords: Anti TPO; Hypothyroidism; T3; T4; TSH; Thyroid Profile