title: The Papillomavirus Episteme: a central resource for papillomavirus sequence data and analysis.
abstract: The goal of the Papillomavirus Episteme (PaVE) is to provide an integrated resource for the analysis of papillomavirus (PV) genome sequences and related information. The PaVE is a freely accessible, web-based tool (http://pave.niaid.nih.gov) created around a relational database, which enables storage, analysis and exchange of sequence information. From a design perspective, the PaVE adopts an Open Source software approach and stresses the integration and reuse of existing tools. Reference PV genome sequences have been extracted from publicly available databases and reannotated using a custom-created tool. To date, the PaVE contains 241 annotated PV genomes, 2245 genes and regions, 2004 protein sequences and 47 protein structures, which users can explore, analyze or download. The PaVE provides scientists with the data and tools needed to accelerate scientific progress for the study and treatment of diseases caused by PVs.
authors.affiliation: DNA Tumor Virus Section, Laboratory of Viral Diseases, Office of Cyber Infrastructure and Computational Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 209892, USA.
authors.forename: Koenraad
authors.initials: K
authors.lastname: Van Doorslaer
authors.forename: Qina
authors.initials: Q
authors.lastname: Tan
authors.forename: Sandhya
authors.initials: S
authors.lastname: Xirasagar
authors.forename: Sandya
authors.initials: S
authors.lastname: Bandaru
authors.forename: Vivek
authors.initials: V
authors.lastname: Gopalan
authors.forename: Yasmin
authors.initials: Y
authors.lastname: Mohamoud
authors.forename: Yentram
authors.initials: Y
authors.lastname: Huyen
authors.forename: Alison A
authors.initials: AA
authors.lastname: McBride
mesh_terms: D030541:Databases, Genetic; D016679:Genome, Viral; D023281:Genomics; D020407:Internet; D058977:Molecular Sequence Annotation; D027383:Papillomaviridae / Q000235:genetics*; D017421:Sequence Analysis; D014584:User-Computer Interface; D014764:Viral Proteins / Q000737:chemistry / Q000235:genetics
chemical_list: D014764:Viral Proteins