title: MS2DB+: a software for determination of disulfide bonds using multi-ion analysis.
abstract: MS2DB+ is an open-source platform-independent web application for determining, in polynomial time, the disulfide linkages in proteins using tandem mass spectrometry (MS/MS) data. It utilizes an efficient approximation algorithm which allows the consideration of multiple ion-types (a, a(o), a*, b, b(o), b*, c, x, y, y(o), y*, and z) in the analysis. Once putative disulfide bonds are identified, a graph optimization approach is used to obtain the most likely global disulfide connectivity pattern.
authors.affiliation: Department of Computer Science, San Francisco State University, San Francisco, CA 94132, USA. whemurad@mail.sfsu.edu
authors.forename: William
authors.initials: W
authors.lastname: Murad
authors.forename: Rahul
authors.initials: R
authors.lastname: Singh
mesh_terms: D000465:Algorithms; D004220:Disulfides / Q000737:chemistry*; D007477:Ions; D011506:Proteins / Q000737:chemistry; D012984:Software; D053719:Tandem Mass Spectrometry
chemical_list: D004220:Disulfides; D007477:Ions; D011506:Proteins