title: Prediction of transporter-mediated drug-drug interactions using endogenous compounds.
abstract: Therapy with two or more drugs is more the rule than the exception, particularly in aging societies. Drug-drug interactions are frequently undesirable and may lead to increased toxicity and mortality. Inhibition of transporters is one major mechanism underlying drug-drug interactions. The myriad of potential drug combinations makes it very challenging to predict drug-drug interactions. This Commentary discusses potential advantages and limitations of endogenous compounds for predicting transporter-mediated drug-drug interactions.
authors.affiliation: Institute of Experimental and Clinical Pharmacology and Toxicology, Friedrich-Alexander Universität Erlangen-Nürnberg, Germany. martin.fromm@pharmakologie.med.uni-erlangen.de
authors.forename: M F
authors.initials: MF
authors.lastname: Fromm
mesh_terms: D006801:Humans; D007668:Kidney / Q000378:metabolism*; D008297:Male; D009536:Niacinamide / Q000031:analogs & derivatives* / Q000378:metabolism; D027701:Organic Cation Transport Proteins / Q000378:metabolism*
chemical_list: D027701:Organic Cation Transport Proteins; C521869:SLC47A1 protein, human; C521870:SLC47A2 protein, human; D009536:Niacinamide; C008472:N-methylnicotinamide