title: Synthesis and antibiofilm activity of marine natural product-based 4-thiazolidinones derivatives.
abstract: 4-Thiazolidinones derivatives of marine bromopyrrole alkaloids were synthesized as potential antibiofilm compounds. Among the synthesized compounds, some showed promising antibiofilm activity. Biological data revealed that 1,3-thiazolidin-4-one derivatives are more potent antibiofilm agents compared to 1,3-thiazinan-4-ones. Antibiofilm activity of compound 4b, 4c (MIC=0.78 μg/ml) was 3-fold superior than standard vancomycin (MIC=3.125 μg/ml) while activity of compound 4d, 4f, 4g and 4h was 2-fold (MIC=1.56 μg/ml) against Staphylococcus aureus biofilm. Compound 4b-4h showed equal antibiofilm activity against Staphylococcus epidermidis compared to standard Vancomycin (MIC=3.125 μg/ml).
authors.affiliation: S.P.P. School of Pharmacy and Technology Management, NMIMS University, Vile Parle, Mumbai 400056, India. rajeshrane_uict@yahoo.co.in
authors.forename: Rajesh A
authors.initials: RA
authors.lastname: Rane
authors.forename: Niteshkumar U
authors.initials: NU
authors.lastname: Sahu
authors.forename: Chetan P
authors.initials: CP
authors.lastname: Shah
mesh_terms: D000470:Alkaloids / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D018441:Biofilms / Q000187:drug effects*; D008826:Microbial Sensitivity Tests; D011758:Pyrroles / Q000737:chemistry; D013211:Staphylococcus aureus / Q000502:physiology; D013212:Staphylococcus epidermidis / Q000502:physiology; D013329:Structure-Activity Relationship; D053778:Thiazolidines / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D014640:Vancomycin / Q000494:pharmacology
chemical_list: D000470:Alkaloids; D000900:Anti-Bacterial Agents; D011758:Pyrroles; D053778:Thiazolidines; D014640:Vancomycin