title: A specific combination of zeaxanthin, spermidine and rutin prevents apoptosis in human dermal papilla cells.
abstract: Hair follicle (HF) regression is characterized by the activation of apoptosis in HF cells. Dermal papilla cells play a leading role in the regulation of HF development and cycling. Human follicular dermal papilla cells (HFDPC) were used to investigate the protective activities of rutin, sperimidine and zeaxanthine. HFDP cell incubation with staurosporine caused apoptosis, which was completely inhibited by exposure to rutin (2.2 μM), spermidine (1 μM) and zeaxanthin (80 μM). These agents were much less effective when applied as single compounds. Moreover, treatment preserved the expression of anti-apoptotic molecules such as Bcl-2, MAP-kinases and their phosphorylated forms. In conclusion, the investigated agents may represent an effective treatment for the prevention of apoptosis, one of the leading events involved in hair bulb regression.
authors.forename: Stephana
authors.initials: S
authors.lastname: Carelli
authors.forename: Danuta M
authors.initials: DM
authors.lastname: Hebda
authors.forename: Maria V
authors.initials: MV
authors.lastname: Traversa
authors.forename: Fanuel
authors.initials: F
authors.lastname: Messaggio
authors.forename: Giammaria
authors.initials: G
authors.lastname: Giuliani
authors.forename: Barbara
authors.initials: B
authors.lastname: Marzani
authors.forename: Anna
authors.initials: A
authors.lastname: Benedusi
authors.forename: Anna M
authors.initials: AM
authors.lastname: Di Giulio
authors.forename: Alfredo
authors.initials: A
authors.lastname: Gorio
mesh_terms: D017209:Apoptosis / Q000187:drug effects*; D002478:Cells, Cultured; D020405:Dermis / Q000166:cytology / Q000187:drug effects; D018859:Hair Follicle / Q000166:cytology / Q000187:drug effects*; D006801:Humans; D012431:Rutin / Q000494:pharmacology*; D013095:Spermidine / Q000494:pharmacology*; D024341:Xanthophylls / Q000494:pharmacology*; D065146:Zeaxanthins
chemical_list: D024341:Xanthophylls; D065146:Zeaxanthins; D012431:Rutin; D013095:Spermidine