title: Reproductive impact of polycystic ovary syndrome.
abstract: OBJECTIVE
  The purpose of this review is to highlight the impact of polycystic ovary syndrome (PCOS) on menstrual function, fertility and reproductive outcomes. Women with PCOS often present with anovulation, menstrual disturbances and hyperandrogenism. Management options for the reproductive disorders of PCOS will be discussed.
  
  
  RESULTS
  The role of metformin in treating PCOS is narrowing. New data show improved live birth rates by skipping a progestin withdrawal bleed and proceeding directly with a dose escalation of clomiphene for ovulation induction. The Pregnancy in PCOS trial II will determine the safety and efficacy of clomiphene citrate compared to letrozole, in achieving live birth in infertile women with PCOS.
  
  
  CONCLUSIONS
  Initial treatment for reproductive disorders in overweight and obese women with PCOS is weight loss. This helps menstrual disturbances, shortens the time to conception and reduces adverse obstetric risks. Clomiphene citrate is considered the first-line therapy for ovulatory infertility. Clomiphene citrate-resistant women may be offered aromatase inhibitors or laparoscopic ovarian surgery. Metformin does not improve live birth rate or reduce miscarriage rate and is no longer considered an option for ovulation induction. Women with PCOS need to be counseled about risks of multiple gestations with gonadotropin therapy.
authors.affiliation: Center for Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Carolinas Medical Center, Charlotte, North Carolina, USA. Rebecca.Usadi@carolinashealthcare.org
authors.forename: Rebecca S
authors.initials: RS
authors.lastname: Usadi
authors.forename: Richard S
authors.initials: RS
authors.lastname: Legro
mesh_terms: D000022:Abortion, Spontaneous / Q000188:drug therapy* / Q000517:prevention & control; D002996:Clomiphene / Q000008:administration & dosage* / Q000494:pharmacology; D005260:Female; D005307:Fertilization in Vitro; D006801:Humans; D007231:Infant, Newborn; D007247:Infertility, Female / Q000188:drug therapy* / Q000209:etiology / Q000601:surgery; D010535:Laparoscopy; D000077289:Letrozole; D008687:Metformin / Q000008:administration & dosage* / Q000494:pharmacology; D009570:Nitriles / Q000008:administration & dosage* / Q000494:pharmacology; D009765:Obesity / Q000150:complications / Q000188:drug therapy*; D010062:Ovulation Induction; D011085:Polycystic Ovary Syndrome / Q000150:complications / Q000188:drug therapy* / Q000601:surgery; D011247:Pregnancy; D011256:Pregnancy Outcome; D014230:Triazoles / Q000008:administration & dosage* / Q000494:pharmacology
chemical_list: D009570:Nitriles; D014230:Triazoles; D002996:Clomiphene; D000077289:Letrozole; D008687:Metformin