title: Spontaneous regression of primary diffuse large B-cell lymphoma, leg type.
abstract: Primary cutaneous diffuse large B-cell lymphoma, leg type (PCLBCL LT) accounts for approximately 20% of all primary cutaneous B-cell lymphomas and tends to present as infiltrated nodules, tumors, and plaques on the legs in the elderly. Unlike other primary cutaneous large B-cell lymphomas, it has a poor prognosis and tends to require treatment with systemic chemotherapy. We present the case of an 82-year-old patient with a 1-year history of nodules and plaques on her right leg. Biopsy led to a diagnosis of PCLBCL LT and the lesions resolved without treatment within 1 month of the first visit. This is an atypical course of PCLBCL LT and we believe that it is the first such case to be reported in the literature.
authors.affiliation: Servicio de Dermatología, Hospital Universitario Ramón y Cajal, Madrid, España. Electronic address: jalcantarag@hotmail.es.
authors.forename: J
authors.initials: J
authors.lastname: Alcántara-González
authors.affiliation: Servicio de Anatomía Patológica, Hospital Universitario Ramón y Cajal, Madrid, España.
authors.forename: C
authors.initials: C
authors.lastname: González-García
authors.affiliation: Servicio de Dermatología, Hospital Universitario Ramón y Cajal, Madrid, España.
authors.forename: M
authors.initials: M
authors.lastname: Fernández-Guarino
authors.affiliation: Servicio de Dermatología, Hospital Universitario Ramón y Cajal, Madrid, España.
authors.forename: P
authors.initials: P
authors.lastname: Jaén-Olasolo
mesh_terms: D000369:Aged, 80 and over; D018951:Antigens, CD20 / Q000032:analysis; D000951:Antigens, Neoplasm / Q000032:analysis; D001402:B-Lymphocytes / Q000737:chemistry / Q000473:pathology; D014408:Biomarkers, Tumor / Q000032:analysis; D001706:Biopsy; D005260:Female; D006801:Humans; D007866:Leg; D016403:Lymphoma, Large B-Cell, Diffuse / Q000175:diagnosis / Q000473:pathology / Q000503:physiopathology*; D008940:Mitotic Index; D009363:Neoplasm Proteins / Q000032:analysis; D009365:Neoplasm Regression, Spontaneous; D012878:Skin Neoplasms / Q000175:diagnosis / Q000473:pathology / Q000503:physiopathology*
chemical_list: D018951:Antigens, CD20; D000951:Antigens, Neoplasm; D014408:Biomarkers, Tumor; D009363:Neoplasm Proteins
keywords: Cutaneous lymphoma; Linfoma cutáneo; Linfoma cutáneo primario difuso de células B grandes tipo pierna; Primary cutaneous diffuse large B-cell lymphoma leg type; Regresión espontánea; Spontaneous regression