title: Increased 5-bromo-2'-deoxyuridine incorporation in various brain structures following passive avoidance training in mice.
abstract: We studied the effects of training on DNA synthesis intensity in mouse brain. Brain cells where DNA synthesis-associated processes took place under the influence of training were detected by immunohistochemical labeling of DNA molecules with synthetic thymine analogue 5-bromo-2'-deoxyuridine. The number of 5-bromo-2'-deoxyuridine-positive cell increased in various structures of the brain under the influence of training.
authors.affiliation: Laboratory of Neurobiology of Memory, PK Anokhin Institute of Normal Physiology, Russian Academy of Medical Sciences, Moscow, Russia. oivashkina@gmail.com
authors.forename: O I
authors.initials: OI
authors.lastname: Ivashkina
authors.forename: M A
authors.initials: MA
authors.lastname: Zots
authors.forename: D V
authors.initials: DV
authors.lastname: Bezriadnov
authors.forename: K V
authors.initials: KV
authors.lastname: Anokhin
mesh_terms: D000704:Analysis of Variance; D000818:Animals; D001345:Autoradiography; D001362:Avoidance Learning / Q000502:physiology*; D001921:Brain / Q000378:metabolism*; D001973:Bromodeoxyuridine / Q000008:administration & dosage / Q000378:metabolism / Q000493:pharmacokinetics*; D004247:DNA / Q000096:biosynthesis* / Q000378:metabolism; D007150:Immunohistochemistry; D007274:Injections, Intraperitoneal; D051379:Mice; D008810:Mice, Inbred C57BL; D018709:Statistics, Nonparametric
chemical_list: D004247:DNA; D001973:Bromodeoxyuridine