title: [Present and future strategies for women at risk, or suffering from premature ovarian failure (POF)].
abstract: The purpose of this review is to present the strategies for fertility preservation that are currently proposed to patients at risk from premature ovarian failure (POF) due to chemotherapy as well as some future solutions that could allow patients already affected by an IOP to recover their fertility. Today, cryo-preservation of pieces of ovarian cortex followed by orthotopic transplantation as well as in vitro maturation of oocytes (IVM) allow preservation of fertility in patients being to undergo an antitumor treatment. However, although promising results have been obtained, the pregnancy rate remains very low. Improvement of these techniques, but also stimulation of resting follicle activation, in vitro folliculogenesis, and culture of putative oogonia that may be present in the adult ovary, are all future opportunities for patients suffering from an IOP, and are currently the subject of intensive researches.
authors.affiliation: CRCL, UMR-Inserm 1052, CNRS 5286, faculté de médecine Laennec, Bâtiment B, 7, rue Guillaume-Paradin, 69372 Lyon cedex 08, France. alain.gougeon@inserm.fr
authors.forename: A
authors.initials: A
authors.lastname: Gougeon
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000009:adverse effects; D015925:Cryopreservation; D005260:Female; D059247:Fertility Preservation / Q000379:methods* / Q000639:trends; D006801:Humans; D009369:Neoplasms / Q000628:therapy; D009865:Oocytes / Q000502:physiology; D006080:Ovarian Follicle / Q000502:physiology; D010053:Ovary / Q000502:physiology / Q000637:transplantation; D011247:Pregnancy; D016649:Primary Ovarian Insufficiency / Q000209:etiology / Q000628:therapy*; D011878:Radiotherapy / Q000009:adverse effects; D016042:Transplantation, Heterotopic
chemical_list: D000970:Antineoplastic Agents