title: Genome-wide alternative polyadenylation in animals: insights from high-throughput technologies.
abstract: Alternative polyadenylation (APA) plays an important role in gene expression by affecting mRNA stability, translation, and translocation in cells. However, genome-wide APA events have only recently been subjected to more systematic analysis with newly developed high-throughput methods. In this review, we focus on the recent technological development of APA analyses on a genome-wide scale, as well as the impact of APA switches on a number of critical biological processes in animals, including cell proliferation, differentiation, and oncogenic transformation. With the highly enlarged scope of genome-wide APA analyses, the APA regulations of various biological processes have increasingly become a new paradigm for the regulation of gene transcription and translation.
authors.affiliation: State Key Laboratory of Biocontrol, National Engineering Center of South China Sea for Marine Biotechnology, Guangdong Province Key Laboratory of Pharmaceutical Functional Genes, Department of Biochemistry, College of Life Sciences, Higher Education Mega Center, Sun Yat-sen University, Guangzhou 510006, China.
authors.forename: Yu
authors.initials: Y
authors.lastname: Sun
authors.forename: Yonggui
authors.initials: Y
authors.lastname: Fu
authors.forename: Yuxin
authors.initials: Y
authors.lastname: Li
authors.forename: Anlong
authors.initials: A
authors.lastname: Xu
mesh_terms: D017398:Alternative Splicing / Q000235:genetics*; D000818:Animals; D016678:Genome / Q000235:genetics*; D057166:High-Throughput Screening Assays / Q000379:methods*; D006801:Humans; D026723:Polyadenylation / Q000235:genetics*; D012333:RNA, Messenger / Q000235:genetics*
chemical_list: D012333:RNA, Messenger