title: Variants on ESR1 and their association with prostate cancer risk: a meta-analysis.
abstract: BACKGROUND
  Epidemiological studies evaluating the association of two variants rs9340799 and rs2234693 on estrogen receptor 1 (ESR1) with prostate risk have generated inconsistent results.
  
  
  METHODS
  A meta-analysis was here conducted to systematically evaluate the relationship of these two variants with prostate cancer susceptibility.
  
  
  RESULTS
  For rs9340799, heterozygosity of T/C carriers showed a significant increased prostate cancer risk with a pooled odds ratio (OR) of 1.34 (95% CI = 1.06-1.69) while homozygote C/C carriers showed an increased but not statistically significant association with prostate cancer risk (pooled OR = 1.29, 95% CI = 0.94-1.79). Compared to the homozygous TT carriers, the allele C carriers showed a 31% increased risk for prostate cancer (pooled OR = 1.31, 95% CI = 1.06-1.63). No significant association between the rs2234693 and prostate cancer risk was found with the pooled OR of 1.15 (95% CI = 0.97-1.39, T/C and C/C vs. T/T) under the dominant genetic model. Compared to the homozygote T/T carriers, the heterozygous T/C carriers did not show any significantly different risk of prostate cancer (pooled OR = 1.13, 95% CI = 0.94-1.36) and the homozygous C/C carriers also did not show a significant change for prostate cancer risk compared to the wide-type T/T carriers (pooled OR = 1.26, 95% CI = 0.98-1.62).
  
  
  CONCLUSIONS
  These data suggested that variant rs9340799, but not rs2234693, on ESR1 confers an elevated risk of prostate cancer.
authors.affiliation: Department of Urology, First Affiliated Hospital of Soochow University, Suzhou, China.
authors.forename: Xiang
authors.initials: X
authors.lastname: Ding
authors.forename: Feng-Mei
authors.initials: FM
authors.lastname: Cui
authors.forename: Song-Tao
authors.initials: ST
authors.lastname: Xu
authors.forename: Jin-Xian
authors.initials: JX
authors.lastname: Pu
authors.forename: Yu-Hua
authors.initials: YH
authors.lastname: Huang
authors.forename: Jiang-Lei
authors.initials: JL
authors.lastname: Zhang
authors.forename: Xue-Dong
authors.initials: XD
authors.lastname: Wei
authors.forename: Jian-Quan
authors.initials: JQ
authors.lastname: Hou
authors.forename: Chun-Yin
authors.initials: CY
authors.lastname: Yan
mesh_terms: D016022:Case-Control Studies; D047628:Estrogen Receptor alpha / Q000235:genetics*; D020022:Genetic Predisposition to Disease; D006801:Humans; D008297:Male; D011110:Polymorphism, Genetic / Q000235:genetics*; D011471:Prostatic Neoplasms / Q000209:etiology*; D012307:Risk Factors
chemical_list: C506487:ESR1 protein, human; D047628:Estrogen Receptor alpha