title: A case-control study to assess the risk of immune thrombocytopenia associated with vaccines.
abstract: The cause of immune thrombocytopenia (ITP) remains unknown. Studies have suggested immunizations as possible triggering factors of ITP through molecular mimicry. This case-control study explored potential associations between adult ITP and various routinely administered vaccines. A network of internal medicine and hematology centers across France recruited 198 incident (ie, newly diagnosed) cases of ITP between April 2008 and June 2011. These cases were compared with 878 age- and sex-matched controls without ITP recruited in general practice. Information on vaccination was obtained from patients' standardized telephone interviews. Sixty-six of 198 cases (33.3%) and 303 of 878 controls (34.5%) received at least 1 vaccine within the 12 months before the index date. We found no evidence of an increase in ITP after vaccination in the previous 6 or 12 months (adjusted odds ratio [OR] for the previous 12 months = 1.0; 95% confidence interval, 0.7-1.4). When the 2-month time window was used, higher ORs were observed for all vaccines (OR = 1.3). This increase was mainly attributable to the vaccination against diphtheria-tetanus-pertussis-poliomyelitis (OR = 1.5) and was not statistically significant. The results of the present study show that in an adult population, the exposure to common vaccines is on average not associated with an observable risk of developing ITP.
authors.affiliation: LA-SER, 10 Place de Catalogne, Paris, France. lamiae.grimaldi@la-ser.com
authors.forename: Lamiae
authors.initials: L
authors.lastname: Grimaldi-Bensouda
authors.forename: Marc
authors.initials: M
authors.lastname: Michel
authors.forename: Elodie
authors.initials: E
authors.lastname: Aubrun
authors.forename: Pamela
authors.initials: P
authors.lastname: Leighton
authors.forename: Jean-Francois
authors.initials: JF
authors.lastname: Viallard
authors.forename: Daniel
authors.initials: D
authors.lastname: Adoue
authors.forename: Nadine
authors.initials: N
authors.lastname: Magy-Bertrand
authors.forename: Guillaume
authors.initials: G
authors.lastname: Tisserand
authors.forename: Mehdi
authors.initials: M
authors.lastname: Khellaf
authors.forename: Jean-Marc
authors.initials: JM
authors.lastname: Durand
authors.forename: Philippe
authors.initials: P
authors.lastname: Quittet
authors.forename: Olivier
authors.initials: O
authors.lastname: Fain
authors.forename: Bernard
authors.initials: B
authors.lastname: Bonnotte
authors.forename: Anne Sophie
authors.initials: AS
authors.lastname: Morin
authors.forename: Nicolas
authors.initials: N
authors.lastname: Limal
authors.forename: Nathalie
authors.initials: N
authors.lastname: Costedoat-Chalumeau
authors.forename: Nathalie
authors.initials: N
authors.lastname: Morel
authors.forename: Brigitte
authors.initials: B
authors.lastname: Pan-Petesch
authors.forename: Olivier
authors.initials: O
authors.lastname: Decaux
authors.forename: Matthieu
authors.initials: M
authors.lastname: Mahevas
authors.forename: Michel
authors.initials: M
authors.lastname: Ruel
authors.forename: Karim
authors.initials: K
authors.lastname: Sacre
authors.forename: Francois
authors.initials: F
authors.lastname: Lefrere
authors.forename: Lucien
authors.initials: L
authors.lastname: Abenhaim
authors.forename: Bertrand
authors.initials: B
authors.lastname: Godeau
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D016022:Case-Control Studies; D022681:Diphtheria-Tetanus-acellular Pertussis Vaccines / Q000009:adverse effects; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D016553:Purpura, Thrombocytopenic, Idiopathic / Q000175:diagnosis / Q000209:etiology*; D012307:Risk Factors; D014611:Vaccination / Q000009:adverse effects; D014612:Vaccines / Q000009:adverse effects*; D055815:Young Adult
chemical_list: D022681:Diphtheria-Tetanus-acellular Pertussis Vaccines; D014612:Vaccines