title: Age trends in the prevalence of cervical squamous intraepithelial lesions among HIV-positive women in Cameroon: a cross-sectional study.
abstract: BACKGROUND
  Cervical squamous intra-epithelial lesions (SIL) are more frequent in HIV-positive women overall. However the appropriate age at which to begin and end cervical cancer screening for early detection of lesions in HIV-positive women is not clear. We assessed the age-specific prevalence of any SIL and SIL requiring colposcopy in HIV-positive women in Cameroon.
  
  
  METHODS
  We enrolled, interviewed and conducted conventional cervical cytology in 282 women, aged 19-68 years, initiating antiretroviral therapy in three clinics in Cameroon. In bivariable analyses, the crude relationship between age and the presence of lesions was assessed using locally weighted regression (LOWESS) methods. In multivariate analyses, generalized linear models with prevalence as the outcome, an identity link and a binomial distribution, were used to estimate prevalence differences. Bias analyses were conducted to assess the potential effect of inaccuracies in cytology.
  
  
  RESULTS
  SIL were detected in 43.5% of the 276 women with satisfactory samples, 17.8% of whom had ASC-H/HSIL. On average, women aged 26 to 59 tended to have a slightly higher prevalence of any SIL than other women (Prevalence difference PD: 6.5%; 95%CI: -11.4, 24.4%). This PD was a function of CD4 count (heterogeneity test p-value =0.09): amongst patients with CD4 counts less than 200cells/uL, the prevalence was higher in patients aged 26-59, while there was essentially no difference amongst women with CD4 counts greater than 200 cells/uL. ASC-H/HSIL were present in women as young as 19 and as old as 62. Overall the prevalence of ASC-H/HSIL increased by 0.7% (95%CI: -3.8%, 5.1%) per decade increase in age.
  
  
  CONCLUSIONS
  Both severe and less severe lesions were prevalent at all ages suggesting little utility of age-targeted screening among HIV-positive women. Nevertheless, the long-term evolution of these lesions needs to be assessed in prospective studies.
authors.affiliation: University of Buea, Box 63, Molyko Buea, Cameroon. atashili@yahoo.ie
authors.forename: Julius
authors.initials: J
authors.lastname: Atashili
authors.forename: William C
authors.initials: WC
authors.lastname: Miller
authors.forename: Jennifer S
authors.initials: JS
authors.lastname: Smith
authors.forename: Peter M
authors.initials: PM
authors.lastname: Ndumbe
authors.forename: George M
authors.initials: GM
authors.lastname: Ikomey
authors.forename: Joseph
authors.initials: J
authors.lastname: Eron
authors.forename: Allen C
authors.initials: AC
authors.lastname: Rinas
authors.forename: Evan
authors.initials: E
authors.lastname: Myers
authors.forename: Adaora A
authors.initials: AA
authors.lastname: Adimora
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D002163:Cameroon / Q000453:epidemiology; D002294:Carcinoma, Squamous Cell / Q000150:complications / Q000453:epidemiology*; D003430:Cross-Sectional Studies; D005260:Female; D015658:HIV Infections / Q000150:complications*; D006801:Humans; D008875:Middle Aged; D015995:Prevalence; D055815:Young Adult; D002578:Uterine Cervical Dysplasia / Q000150:complications / Q000453:epidemiology*