title: Facial Soft Tissue Augmentation using Autologous Fat Mixed with Stromal Vascular Fraction.
abstract: BACKGROUND
  Autologous fat grafting evolved over the twentieth century to become a quick, safe, and reliable method for restoring volume. However, autologous fat grafts have some problems including uncertain viability of the grafted fat and a low rate of graft survival. To overcome the problems associated with autologous fat grafts, we used uncultured adipose tissue-derived stromal cell (stromal vascular fraction, SVF) assisted autologous fat grafting. Thus, the purpose of this study was to evaluate the effect of SVF in a clinical trial.
  
  
  METHODS
  SVF cells were freshly isolated from half of the aspirated fat and were used in combination with the other half of the aspirated fat during the procedure. Between March 2007 and February 2008, a total of 9 SVF-assisted fat grafts were performed in 9 patients. The patients were followed for 12 weeks after treatment. Data collected at each follow-up visit included clinical examination of the graft site(s), photographs for historical comparison, and information from a patient questionnaire that measured the outcomes from the patient perspective. The photographs were evaluated by medical professionals.
  
  
  RESULTS
  Scores of the left facial area grafted with adipose tissue mixed with SVF cells were significantly higher compared with those of the right facial area grafted with adipose tissue without SVF cells. There was no significant adverse effect.
  
  
  CONCLUSIONS
  The subjective patient satisfaction survey and surgeon survey showed that SVF-assisted fat grafting was a surgical procedure with superior results.
authors.affiliation: Department of Plastic Surgery, Korea University Anam Hospital, Korea University College of Medicine, Seoul, Korea.
authors.forename: Sang Kyun
authors.initials: SK
authors.lastname: Lee
authors.forename: Deok-Woo
authors.initials: DW
authors.lastname: Kim
authors.forename: Eun-Sang
authors.initials: ES
authors.lastname: Dhong
authors.forename: Seung-Ha
authors.initials: SH
authors.lastname: Park
authors.forename: Eul-Sik
authors.initials: ES
authors.lastname: Yoon
keywords: Adipose tissue; Cell transplants; Mesenchymal stem cells; Tissue grafts