title: Circulating soluble lectin-like oxidized low-density lipoprotein receptor-1 levels are associated with erectile dysfunction in patients without known coronary artery disease.
abstract: OBJECTIVE
  Endothelial dysfunction and microvascular damage are involved in the pathogenesis of erectile dysfunction (ED). Soluble lectin-like oxidized low-density lipoprotein receptor-1 (sLOX-1) is identified endothelial receptor for oxidized low-density lipoprotein (ox-LDL) that plays a pivotal role in ox-LDL-induced endothelial dysfunction. The purpose of the current study was to determine the association between sLOX-1 and ED in patients without known coronary artery disease (CAD).
  
  
  METHODS
  Diagnosis of ED was based on the International Index of Erectile Function Score-5. Levels of sLOX-1 were measured in serum by enzyme-linked immunosorbent assay.
  
  
  METHODS
  One hundred thirty-eight subjects with ED patients without known CAD (ED group) and 75 age-matched subjects without ED and known CAD (Non-ED Group) were included in this study.
  
  
  RESULTS
  Plasma levels of sLOX-1 were significantly higher in ED than in Non-ED group (95±87 and 49±30 pg/mL, respectively, P<0.001). The levels of sLOX-1 highly negative correlated with score of ED (r=-0.618, P<0.001). The sLOX-1 levels>75 pg/mL predicts ED with 26.8% sensitivity and 96.0% specificity on receiver operator characteristic analysis.
  
  
  CONCLUSIONS
  Our study demonstrated that serum sLOX-1 levels were associated with endothelial dysfunction that predicts ED. Moreover, the current study revealed that there was strong negative correlation between the levels of circulating sLOX-1 and score of ED. This study suggested sLOX-1 may be involved in the pathogenesis of ED in patients without known CAD.
authors.affiliation: Department of Cardiology, Elazig Education and Research Hospital, Elazıg, Turkey Department of Urology, University of Firat, Faculty of Medicine, Elazıg, Turkey Department of Internal Medicine, School of Medicine, Inonu University, Malatya, Turkey.
authors.forename: Mehmet Ali
authors.initials: MA
authors.lastname: Kobat
authors.forename: Fatih
authors.initials: F
authors.lastname: Fırdolas
authors.forename: Mehmet
authors.initials: M
authors.lastname: Balin
authors.forename: Ahmet
authors.initials: A
authors.lastname: Çelik
authors.forename: Recep
authors.initials: R
authors.lastname: Bentli
authors.forename: Adil
authors.initials: A
authors.lastname: Baydas
mesh_terms: D016022:Case-Control Studies; D003324:Coronary Artery Disease / Q000097:blood; D004797:Enzyme-Linked Immunosorbent Assay; D007172:Erectile Dysfunction / Q000097:blood*; D006801:Humans; D008297:Male; D008875:Middle Aged; D012372:ROC Curve; D051127:Scavenger Receptors, Class E / Q000097:blood*
chemical_list: D051127:Scavenger Receptors, Class E
keywords: Endothelial Function; Erectile Dysfunction; Microvascular Damage; Soluble Lectin-Like Oxidized Low-Density Lipoprotein Receptor-1