title: [Management of alcoholic hepatitis].
abstract: Alcoholic hepatitis is a severe form of alcoholic liver disease. Diagnosis is based on the association of new onset of jaundice and a compatible liver biopsy. Alcoholic hepatitis is severe when the Maddrey is up to 32 and, in this case, is associated with a mortality of 40-50% at 2 months. Corticosteroids improve survival of patients suffering from severe alcoholic hepatitis. The decrease of total bilirubin at day 7 of treatment and the Lille score are markers of response to corticosteroids. The absence of response is associated with a dramatic outcome (mortality rate of 75% at 6 months). Liver transplantation could be an alternative in a strictly selected group of non-responders.
authors.affiliation: Service de Gastroentérologie et d'Hépatopancréatologie, Hôpital Erasme et Laboratoire de Gastroentérologie Expérimentale, Faculté de Médecine, ULB, Bruxelles. tgustot@ulb.ac.be
authors.forename: T
authors.initials: T
authors.lastname: Gustot
authors.forename: C
authors.initials: C
authors.lastname: Moreno
mesh_terms: D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D006519:Hepatitis, Alcoholic / Q000175:diagnosis / Q000453:epidemiology / Q000401:mortality / Q000628:therapy*; D006801:Humans; D016031:Liver Transplantation / Q000379:methods / Q000706:statistics & numerical data; D018579:Patient Selection; D016896:Treatment Outcome
chemical_list: D000305:Adrenal Cortex Hormones