title: Pedometer step counts and oxidized low-density lipoprotein levels among asymptomatic subjects.
abstract: While daily step counts are considered to be a useful measure of cardiovascular health, the biochemical predictors of step counts have not been fully characterized. This study investigated the correlation between pedometer-determined daily step counts and cardiometabolic variables, including the serum level of malondialdehyde-modified low-density lipoprotein (MDA-LDL), among asymptomatic subjects (n = 50, mean age 63 years). Simple and stepwise multiple linear correlation tests revealed that there was a significant inverse correlation between the step counts and MDA-LDL levels (r = -0.41, P < 0.01; β = -0.38, P < 0.01). The data suggest that daily steps may be beneficially associated with atherosclerosis in correlation with reduced oxidized low-density lipoprotein, and in addition that the MDA-LDL level may be used as a measure reflective of the daily steps.
authors.affiliation: Department of Clinical Laboratory Medicine, Jichi Medical University, Tochigi, Japan. kazukotani@jichi.ac.jp
authors.forename: Kazuhiko
authors.initials: K
authors.lastname: Kotani
authors.forename: Nobuyuki
authors.initials: N
authors.lastname: Taniguchi
mesh_terms: D000368:Aged; D015415:Biomarkers / Q000097:blood*; D002318:Cardiovascular Diseases / Q000175:diagnosis*; D004797:Enzyme-Linked Immunosorbent Assay; D006801:Humans; D016014:Linear Models; D008077:Lipoproteins, LDL / Q000097:blood*; D008315:Malondialdehyde / Q000031:analogs & derivatives* / Q000097:blood; D008875:Middle Aged; D016138:Walking / Q000502:physiology*
chemical_list: D015415:Biomarkers; D008077:Lipoproteins, LDL; C569869:malondialdehyde-low density lipoprotein, human; D008315:Malondialdehyde