title: A bilateral primary yolk sac tumor of the lung associated with chromosome 3 polysomy: understanding the Oct 3/4 and Sox 2 interaction.
abstract: Extragonadal germ cell tumors (EGCTs) in the lung are extremely rare and their pathogenesis is poorly understood. We report a case in a 48-year-old female which was very aggressive and stained positive for primoridial germ cell markers. Interestingly, there was chromosome 3 polysomy noted. To our knowledge this is the first chromosomal aberration noted in a primary germ cell tumor of the lung.
authors.forename: Shitij
authors.initials: S
authors.lastname: Arora
authors.forename: Harish
authors.initials: H
authors.lastname: Patel
authors.forename: Pervez
authors.initials: P
authors.lastname: Mir
authors.forename: Sneha
authors.initials: S
authors.lastname: Mishra
authors.forename: Amita
authors.initials: A
authors.lastname: Kalra
authors.forename: Harinder
authors.initials: H
authors.lastname: Sawhney
authors.forename: Frantz
authors.initials: F
authors.lastname: Duffoo
authors.forename: Mike
authors.initials: M
authors.lastname: Macera
authors.forename: Afaf
authors.initials: A
authors.lastname: Abdu
authors.forename: William
authors.initials: W
authors.lastname: Thelmo
mesh_terms: D000782:Aneuploidy; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D002893:Chromosomes, Human, Pair 3; D002945:Cisplatin / Q000008:administration & dosage; D019008:Drug Resistance, Neoplasm; D018240:Endodermal Sinus Tumor / Q000000981:diagnostic imaging* / Q000188:drug therapy / Q000235:genetics; D005047:Etoposide / Q000008:administration & dosage; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000000981:diagnostic imaging* / Q000188:drug therapy / Q000235:genetics; D050814:Octamer Transcription Factor-3 / Q000235:genetics / Q000378:metabolism*; D011859:Radiography; D055748:SOXB1 Transcription Factors / Q000235:genetics*
chemical_list: D050814:Octamer Transcription Factor-3; C494173:POU5F1 protein, human; C527782:SOX2 protein, human; D055748:SOXB1 Transcription Factors; D005047:Etoposide; D002945:Cisplatin