title: Synthesis and Evaluation of N-substituted Imidazole Derivatives for Antimicrobial Activity.
abstract: A series of N-substituted imidazole derivatives was synthesized. Imidazole nucleus was reacted with ethylchloroacetate to form imidazole ester. Reaction of the imidazole ester (I) with different amines yields the desired products (1a- 1e). The compounds were characterized by FT-IR, (1)H-NMR and mass spectra. The synthesized compounds were evaluated for the antimicrobial activity against Staphylococcus aureus, Bacillus subtilis, Escherichia coli, Pseudomonas aeruginosa, Candida albicans and Aspergillus niger by determination of MIC (minimum inhibitory concentration) using tube dilution method. Compound (1b) was found to be the most active antimicrobial compound amongst others in the series.
authors.affiliation: Department of Pharmaceutical Chemistry, Delhi Institute of Pharmaceutical Sciences and Research (DIPSAR), Sector-3, Pushp Vihar, New Delhi-110 017, India.
authors.forename: Namita
authors.initials: N
authors.lastname: Gupta
authors.forename: D P
authors.initials: DP
authors.lastname: Pathak
keywords: 1H-NMR; FT-IR; imidazole; minimum inhibitory concentration; tube dilution method