title: Intracerebrally applied botulinum neurotoxin in experimental neuroscience.
abstract: The use of botulinum neurotoxins (BoNTs) for therapeutic purposes in neuromuscular disorders and peripheral hypercholinergic conditions as well as in aesthetic medicine is widespread and common. BoNTs are also able to block the release of a wide range of transmitters from presynaptic boutons. Therefore, application of BoNTs directly in the central nervous system (CNS) is currently under study with respect to basic research and potentially as a new therapeutic strategy of neurological diseases. Investigations concentrate on effects of intracerebral and intraspinal application of BoNTs in rodents on the impact on spinal, nuclear, limbic and cortical neuronal circuits. In animal model first promising BoNT-induced therapeutical benefit has been shown in the treatment of pain, epilepsy, stroke and Parkinson's disease.
authors.affiliation: Department of Anatomy, University of Rostock, Germany. alexander.hawlitschka@uni-rostock.de
authors.forename: Alexander
authors.initials: A
authors.lastname: Hawlitschka
authors.forename: Veronica
authors.initials: V
authors.lastname: Antipova
authors.forename: Oliver
authors.initials: O
authors.lastname: Schmitt
authors.forename: Martin
authors.initials: M
authors.lastname: Witt
authors.forename: Reiner
authors.initials: R
authors.lastname: Benecke
authors.forename: Eilhard
authors.initials: E
authors.lastname: Mix
authors.forename: Andreas
authors.initials: A
authors.lastname: Wree
mesh_terms: D000818:Animals; D001905:Botulinum Toxins / Q000008:administration & dosage*; D002493:Central Nervous System Diseases / Q000188:drug therapy; D006801:Humans; D007267:Injections
chemical_list: D001905:Botulinum Toxins