title: The X proteins of bornaviruses interfere with type I interferon signalling.
abstract: Borna disease virus (BDV) is a neurotropic, negative-stranded RNA virus causing persistent infection and progressive neurological disorders in a wide range of warm-blooded animals. The role of the small non-structural X protein in viral pathogenesis is not completely understood. Here we investigated whether the X protein of BDV and avian bornavirus (ABV) interferes with the type I interferon (IFN) system, similar to other non-structural proteins of negative-stranded RNA viruses. In luciferase reporter assays, we found that the X protein of various bornaviruses interfered with the type I IFN system at all checkpoints investigated, in contrast to previously reported findings, resulting in reduced type I IFN secretion.
authors.affiliation: Swedish University of Agricultural Sciences, Department of Clinical Sciences, Division of Ruminant Medicine and Veterinary Epidemiology, PO Box 7054, SE-750 07 Uppsala, Sweden.|Swedish University of Agricultural Sciences, Department of Biomedical Sciences and Veterinary Public Health, Section of Virology, PO Box 7028, SE-750 07 Uppsala, Sweden.
authors.forename: Jonas Johansson
authors.initials: JJ
authors.lastname: Wensman
authors.affiliation: Swedish University of Agricultural Sciences, Department of Biomedical Sciences and Veterinary Public Health, Section of Virology, PO Box 7028, SE-750 07 Uppsala, Sweden.
authors.forename: Muhammad
authors.initials: M
authors.lastname: Munir
authors.affiliation: Swedish University of Agricultural Sciences, Department of Biomedical Sciences and Veterinary Public Health, Section of Virology, PO Box 7028, SE-750 07 Uppsala, Sweden.
authors.forename: Srinivas
authors.initials: S
authors.lastname: Thaduri
authors.affiliation: Swedish University of Agricultural Sciences, Department of Biomedical Sciences and Veterinary Public Health, Section of Virology, PO Box 7028, SE-750 07 Uppsala, Sweden.
authors.forename: Katarina
authors.initials: K
authors.lastname: Hörnaeus
authors.affiliation: Swedish University of Agricultural Sciences, Department of Biomedical Sciences and Veterinary Public Health, Section of Virology, PO Box 7028, SE-750 07 Uppsala, Sweden.
authors.forename: Muhammad
authors.initials: M
authors.lastname: Rizwan
authors.affiliation: Swedish University of Agricultural Sciences, Department of Biomedical Sciences and Veterinary Public Health, Section of Virology, PO Box 7028, SE-750 07 Uppsala, Sweden.
authors.forename: Anne-Lie
authors.initials: AL
authors.lastname: Blomström
authors.affiliation: Columbia University, Mailman School of Public Health, Center for Infection and Immunity, 722 West 168th Street, 10032 New York, NY, USA.
authors.forename: Thomas
authors.initials: T
authors.lastname: Briese
authors.affiliation: Columbia University, Mailman School of Public Health, Center for Infection and Immunity, 722 West 168th Street, 10032 New York, NY, USA.
authors.forename: W Ian
authors.initials: WI
authors.lastname: Lipkin
authors.affiliation: Swedish University of Agricultural Sciences, Department of Biomedical Sciences and Veterinary Public Health, Section of Virology, PO Box 7028, SE-750 07 Uppsala, Sweden.
authors.forename: Mikael
authors.initials: M
authors.lastname: Berg
mesh_terms: D000818:Animals; D028981:Bornaviridae / Q000276:immunology* / Q000472:pathogenicity*; D002460:Cell Line; D004847:Epithelial Cells / Q000276:immunology / Q000821:virology; D017930:Genes, Reporter; D006801:Humans; D057131:Immune Evasion; D007370:Interferon Type I / Q000037:antagonists & inhibitors*; D008156:Luciferases / Q000032:analysis / Q000235:genetics; D008969:Molecular Sequence Data; D012367:RNA, Viral / Q000235:genetics; D017422:Sequence Analysis, DNA; D017361:Viral Nonstructural Proteins / Q000276:immunology / Q000378:metabolism*; D037521:Virulence Factors / Q000276:immunology / Q000378:metabolism*
chemical_list: D007370:Interferon Type I; D012367:RNA, Viral; D017361:Viral Nonstructural Proteins; D037521:Virulence Factors; D008156:Luciferases