title: Ergotamine-associated valvulopathy with recurrent chylous pleural effusion.
abstract: We report a rare case of ergotamine-associated mitral stenosis in a 55-year-old woman who presented with recurrent chylous pleural effusion. Echocardiographic, gross, and microscopic features of the mitral valve were consistent with chronic ergotamine-induced valvulopathy. We conclude that medication-induced valvulopathy should be included in the differential diagnosis of valvular heart disease. In addition, cardiac function should be monitored before and during long-term therapy with ergotamine or ergotamine-derived dopamine agonists.
authors.affiliation: Department of Internal Medicine, Mayo Clinic, Rochester, Minnesota 55905, USA.
authors.forename: John P
authors.initials: JP
authors.lastname: Bois
authors.forename: Vara Venkata
authors.initials: VV
authors.lastname: Ponnada
authors.forename: D Fearghas
authors.initials: DF
authors.lastname: O'Cochlain
authors.forename: Peter A
authors.initials: PA
authors.lastname: Brady
authors.forename: William D
authors.initials: WD
authors.lastname: Edwards
authors.forename: Kyle W
authors.initials: KW
authors.lastname: Klarich
mesh_terms: D002916:Chylothorax / Q000139:chemically induced* / Q000175:diagnosis; D018491:Dopamine Agonists / Q000009:adverse effects*; D018618:Echocardiography, Doppler, Color; D017548:Echocardiography, Transesophageal; D004878:Ergotamine / Q000009:adverse effects*; D005260:Female; D019918:Heart Valve Prosthesis Implantation; D006801:Humans; D008875:Middle Aged; D008946:Mitral Valve Stenosis / Q000139:chemically induced* / Q000175:diagnosis / Q000601:surgery; D010996:Pleural Effusion / Q000139:chemically induced* / Q000175:diagnosis; D011237:Predictive Value of Tests; D012008:Recurrence; D016896:Treatment Outcome
chemical_list: D018491:Dopamine Agonists; D004878:Ergotamine
keywords: Chylothorax/etiology; ergot alkaloids/adverse effects; ergotamine/adverse effects; heart valve diseases/chemically induced; mitral valve stenosis/chemically induced/surgery; muscle relaxants, central/adverse effects; pleural diseases/chemically induced; pleural effusion/chemically induced; serotonin