title: Predictive factors of impaired quality of life in Korean patients with inactive inflammatory bowel disease: association with functional gastrointestinal disorders and mood disorders.
abstract: OBJECTIVE
  Inflammatory bowel disease is a chronic and relapsing inflammatory disorder of the intestine and has a great effect on patients' health-related quality of life (HRQOL). Some patients in remission are known to show functional gastrointestinal disorders (FGIDs) and mood disorders (MDs), which may also negatively impact HRQOL. The aim of this study was to evaluate predictors of impaired HRQOL in inactive inflammatory bowel disease (IBD) patients.
  
  
  METHODS
  Patients presenting a long-standing remission during the previous year completed questionnaires of EuroQol, Rome III criteria for FGID, and Hospital Anxiety and Depression Survey. Demographic data including age, sex, employment status, education, smoking, and location of residence were also collected.
  
  
  RESULTS
  Among the 513 patients with IBD, 226 (Crohn's disease 107 and ulcerative colitis 119, age 39.01±15.63, male 141) defined in remission were enrolled. Overall, 147 (65.0%) had at least 1 FGID with irritable bowel syndrome being the most common disorder (36.3%). Anxiety and depression were identified in 27.4% and 33.6%, respectively. Participants with FGID or MD had a significantly lower HRQOL status than those without disorders (P<0.01). Among various demographic and clinical variables, aged 40 or older [odds ratio (OR), 2.342; 95% confidence interval (CI), 1.195-4.590; P=0.01], irritable bowel syndrome (OR, 3.932; 95% CI, 1.937-7.982; P<0.01), and anxiety (OR, 2.423; 95% CI, 1.067-5.502; P=0.03) were significant independent predictors of impaired HRQOL in inactive IBD patients.
  
  
  CONCLUSIONS
  FGID and MD are common in Korean quiescent IBD patients. Appropriate management should be administered according to age of patients and presence of concomitant FGID and MD to improve patients' HRQOL.
authors.affiliation: Department of Internal Medicine, Division of Gastroenterology, School of Medicine, Keimyung University, Daegu, Korea.
authors.forename: Eun S
authors.initials: ES
authors.lastname: Kim
authors.forename: Kwang B
authors.initials: KB
authors.lastname: Cho
authors.forename: Kyung S
authors.initials: KS
authors.lastname: Park
authors.forename: Byung I
authors.initials: BI
authors.lastname: Jang
authors.forename: Kyeong O
authors.initials: KO
authors.lastname: Kim
authors.forename: Seong W
authors.initials: SW
authors.lastname: Jeon
authors.forename: Min K
authors.initials: MK
authors.lastname: Jung
authors.forename: Eun Y
authors.initials: EY
authors.lastname: Kim
authors.forename: Chang H
authors.initials: CH
authors.lastname: Yang
mesh_terms: D000328:Adult; D000339:Affect; D000367:Age Factors; D001007:Anxiety / Q000523:psychology; D044466:Asian People / Q000523:psychology; D016022:Case-Control Studies; D016009:Chi-Square Distribution; D003093:Colitis, Ulcerative / Q000208:ethnology / Q000523:psychology*; D015897:Comorbidity; D017281:Cost of Illness; D003424:Crohn Disease / Q000208:ethnology / Q000523:psychology*; D003863:Depression / Q000523:psychology; D005260:Female; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D019964:Mood Disorders / Q000208:ethnology / Q000523:psychology*; D015999:Multivariate Analysis; D016017:Odds Ratio; D015995:Prevalence; D011788:Quality of Life; D012074:Remission Induction; D056910:Republic of Korea / Q000453:epidemiology; D018570:Risk Assessment; D012307:Risk Factors; D011795:Surveys and Questionnaires; D055815:Young Adult