title: Natural killer/T-cell lymphoma, nasal type, masquerading as recalcitrant periodontitis in a patient with a diagnosis of Wegener's granulomatosis.
abstract: Extranodal natural killer (NK)/T-cell lymphoma, nasal type, is a rare type of non-Hodgkin's lymphoma with similar presentation to various benign inflammatory diseases. Adequate biopsy is required for a diagnosis because this lymphoma frequently coexists with large amount of necrosis and inflammation. In this study, a case of a 49-year-old woman presenting with a 3-week history of right maxillary alveolar ridge pain with a subsequent diagnosis of periodontitis is described. The patient's clinical condition deteriorated over a period of 6 weeks. Computed tomography delineated involvement of the right maxillary sinus, posterior part of the right pharynx and right nasal cavity. Immunohistopathology initially revealed Wegener's granulomatosis, followed by extranodal nasal-type NK/T-cell lymphoma. Severe refractory periodontitis in a background of Wegener's granulomatosis may be the initial presentation of extranodal NK/T-cell lymphoma, nasal type. In addition to careful examination, radiographic and laboratory testing, multiple large biopsies should be taken for immunohistochemical analysis to obtain an appropriate diagnosis.
authors.affiliation: Departments of Dermatology, Venereology and Allergology, Medical University of Gdańsk, Gdańsk, Poland. mwojd@gumed.edu.pl
authors.forename: Małgorzata
authors.initials: M
authors.lastname: Sokołowska-Wojdyło
authors.forename: Aleksandra
authors.initials: A
authors.lastname: Florek
authors.forename: Wioletta
authors.initials: W
authors.lastname: Barańska-Rybak
authors.forename: Monika
authors.initials: M
authors.lastname: Sikorska
authors.forename: Anna
authors.initials: A
authors.lastname: Starzyńska
authors.forename: Barbara
authors.initials: B
authors.lastname: Drogoszewska
authors.forename: Adam
authors.initials: A
authors.lastname: Włodarkiewicz
mesh_terms: D003937:Diagnosis, Differential; D017809:Fatal Outcome; D005260:Female; D014890:Granulomatosis with Polyangiitis / Q000150:complications / Q000175:diagnosis*; D006801:Humans; D054391:Lymphoma, Extranodal NK-T-Cell / Q000150:complications / Q000175:diagnosis*; D008875:Middle Aged; D009669:Nose Neoplasms / Q000150:complications / Q000175:diagnosis*; D010518:Periodontitis / Q000150:complications / Q000175:diagnosis*