title: Multifunctional Au@mSiO2/rhodamine B isothiocyanate nanocomposites: cell imaging, photocontrolled drug release, and photothermal therapy for cancer cells.
abstract: The synthesis of Au@mesoporous SiO(2)/rhodamine B isothiocyanate (Au@mSiO(2)/RBITC) composite nanoparticles (NPs) is presented and their unique biofunctional properties are studied. The structure and morphology of the NPs are characterized by X-ray powder diffraction, transmission electron microscopy, and Fourier transform infrared spectroscopy. These NPs can not only be functionalized for fluorescence imaging, but also possess well-defined mesopore structures for drug loading and strong infrared surface plasmon absorption for light-controlled drug release and photothermal therapy for cancer cells. In the biological experiments, one 808 nm laser is coupled to a confocal laser scanning microscopy (CLSM) system to monitor the photothermal therapy, drug release, and cell position and viability in real time by using the multichannel function of CLSM for the first time. Such novel nanomaterials offer a new chemotherapeutic route for cancer treatment by combining cell imaging and hyperthermia in a synergistic way.
authors.affiliation: State Key Laboratory on Integrated Optoelectronics, College of Electronic Science and Engineering, Jilin University, Changchun 130012, China.
authors.forename: Zhenlong
authors.initials: Z
authors.lastname: Jiang
authors.forename: Biao
authors.initials: B
authors.lastname: Dong
authors.forename: Boting
authors.initials: B
authors.lastname: Chen
authors.forename: Jing
authors.initials: J
authors.lastname: Wang
authors.forename: Lin
authors.initials: L
authors.lastname: Xu
authors.forename: Shuang
authors.initials: S
authors.lastname: Zhang
authors.forename: Hongwei
authors.initials: H
authors.lastname: Song
mesh_terms: D002470:Cell Survival / Q000187:drug effects; D006046:Gold / Q000737:chemistry*; D056945:Hep G2 Cells; D006801:Humans; D006979:Hyperthermia, Induced; D018613:Microscopy, Confocal; D053761:Nanocomposites / Q000737:chemistry / Q000627:therapeutic use*; D012235:Rhodamines / Q000737:chemistry*; D012822:Silicon Dioxide / Q000737:chemistry*
chemical_list: D012235:Rhodamines; D006046:Gold; D012822:Silicon Dioxide; C027755:rhodamine isothiocyanate