title: [The condition of endothelium and hemostasis in patients with primary diagnosed acute lymphoblast leucosis].
abstract: The evaluation of state of endothelium and plasma hemostasis, thrombocytopenia degree, rate of thrombo-hemorrhagic complications in adult patients with acute lymphoblastic leucosis in the period of disease manifestation was made. The thrombosis developed in 1 out of 24 (4.2%) examined patients, hemorrhagic syndrome in 11 out of 24 (45.8%) examined patients. The last case is closely linked with severity of thrombocytopenia occurred in patients with number of thrombocytes less than 50 x 109/l. At the same time, high correlation between number of leukemic cells and level of B-dimers (rs = 0.703) testifies that the leucosis process activates intravascular thrombus formation. The higher content of B-dimers in 100% of patients validates this assumption. The high levels of soluble thrombo-modulin and von Willebrand factor indicate the loss of thromboresistance by vessel endothelium and the activation of prothrombin mechanisms. The statistically valid coefficients of correlation between concentrations of thrombomodulin and D-dimers (rs = 0.598) and the level of von Willebrand factor and severity of hemorrhagic syndrome prove that disorders of blood coagulation under acute lymphoblast leucosis occur with active involvement of endothelium.
authors.forename: S G
authors.initials: SG
authors.lastname: Vladimorova
authors.forename: O Iu
authors.initials: OIu
authors.lastname: Skol'skaia
authors.forename: L N
authors.initials: LN
authors.lastname: Tarasova
authors.forename: I A
authors.initials: IA
authors.lastname: Dokshina
mesh_terms: D000328:Adult; D000368:Aged; D004730:Endothelium, Vascular / Q000378:metabolism* / Q000473:pathology; D005260:Female; D005338:Fibrin Fibrinogen Degradation Products / Q000378:metabolism; D006470:Hemorrhage / Q000097:blood* / Q000175:diagnosis / Q000209:etiology; D006487:Hemostasis; D006801:Humans; D008297:Male; D008875:Middle Aged; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000097:blood* / Q000150:complications / Q000175:diagnosis / Q000473:pathology; D013921:Thrombocytopenia / Q000097:blood* / Q000175:diagnosis / Q000209:etiology; D018180:Thrombomodulin / Q000378:metabolism; D013927:Thrombosis / Q000097:blood* / Q000175:diagnosis / Q000209:etiology; D014841:von Willebrand Factor / Q000378:metabolism
chemical_list: D005338:Fibrin Fibrinogen Degradation Products; D018180:Thrombomodulin; C036309:fibrin fragment D; D014841:von Willebrand Factor