title: Strynuxlines A and B, alkaloids with an unprecedented carbon skeleton from Strychnos nux-vomica.
abstract: The investigation of the seeds of Strychnos nux-vomica led to the isolation of two novel indole alkaloids, strynuxlines A (1) and B (2), with an unprecedented 6/5/9/6/7/6 hexacyclic ring system. Their structures and absolute configurations were elucidated on the basis of their MS, NMR, and ECD data. A plausible biosynthesis pathway of 1 and 2 is also proposed.
authors.affiliation: State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences , Kunming 650201, Yunnan, People's Republic of China.
authors.forename: Yanhui
authors.initials: Y
authors.lastname: Fu
authors.forename: Yu
authors.initials: Y
authors.lastname: Zhang
authors.forename: Hongping
authors.initials: H
authors.lastname: He
authors.forename: Li
authors.initials: L
authors.lastname: Hou
authors.forename: Yingtong
authors.initials: Y
authors.lastname: Di
authors.forename: Shunlin
authors.initials: S
authors.lastname: Li
authors.forename: Xiaodong
authors.initials: X
authors.lastname: Luo
authors.forename: Xiaojiang
authors.initials: X
authors.lastname: Hao
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry* / Q000302:isolation & purification* / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D004365:Drugs, Chinese Herbal / Q000737:chemistry* / Q000302:isolation & purification* / Q000494:pharmacology; D018922:HL-60 Cells; D006801:Humans; D026121:Indole Alkaloids / Q000737:chemistry* / Q000302:isolation & purification* / Q000494:pharmacology; D020128:Inhibitory Concentration 50; D015394:Molecular Structure; D012639:Seeds / Q000737:chemistry; D013331:Strychnine / Q000302:isolation & purification; D031461:Strychnos nux-vomica / Q000737:chemistry*
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D004365:Drugs, Chinese Herbal; D026121:Indole Alkaloids; C587746:strynuxline A; C587747:strynuxline B; D013331:Strychnine