title: Antioxidant, Lipoxygenase and Histone Deacetylase Inhibitory Activities of Acridocarpus orientalis from Al Ain and Oman [corrected].
abstract: Acridocarpus orientalis (AO) is a traditional medicinal plant used for treatment of inflammatory diseases that may have potential in cancer treatment. In the present study, the aqueous ethanolic crude extract of Acridocarpus aerial parts obtained from Al Ain  and Oman were evaluated for their antioxidant capability, polyphenolic content,  anti-lipoxygenase and anti-histone deacetylase (HDAC) properties. The total antioxidant capacity was estimated by the FRAP, DPPH, ABTS and b-carotene bleaching assays. Acridocarpus-Al Ain exhibited the highest polyphenolic content (184.24 mg gallic acid/g) and the best antioxidant activity (1.1, 1.04, 1.14 mmol ascorbic acid equivalent/g in the FRAP, ABTS and DPPH assays, respectively). Additionally, the same extract showed significant anti-inflammatory properties via lipoxygenase (LOX) inhibitory activity  (IC(50) = 50.58 &#181;g/mL). Acridocarpus-Al Ain also showed the strongest histone deacetylase (HDACs) inhibitory activity (IC(50) = 93.28 &#181;g/mL). The results reported here suggest that there was a significant influence of location and the plant may be considered a good source of compounds with antioxidant, anti-LOX and HDAC properties for therapeutic, nutraceutical and functional food applications.
authors.affiliation: Department of Biology, U.A.E. University, Al-Ain, UAE. tksiksi@uacu.ac.ae
authors.forename: Taoufik
authors.initials: T
authors.lastname: Ksiksi
authors.forename: Alaaeldin A
authors.initials: AA
authors.lastname: Hamza
mesh_terms: D052160:Benzothiazoles / Q000737:chemistry; D001713:Biphenyl Compounds / Q000737:chemistry; D000431:Ethanol / Q000737:chemistry; D016166:Free Radical Scavengers / Q000737:chemistry*; D006367:HeLa Cells; D056572:Histone Deacetylase Inhibitors / Q000737:chemistry*; D006655:Histone Deacetylases / Q000737:chemistry; D006801:Humans; D008084:Lipoxygenase / Q000737:chemistry; D016859:Lipoxygenase Inhibitors / Q000737:chemistry*; D029581:Malpighiaceae / Q000737:chemistry*; D008519:Medicine, Traditional; D009850:Oman; D010851:Picrates / Q000737:chemistry; D035261:Plant Components, Aerial / Q000737:chemistry; D010936:Plant Extracts / Q000737:chemistry*; D010940:Plant Proteins / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry; D059808:Polyphenols / Q000737:chemistry; D012997:Solvents / Q000737:chemistry; D013025:Glycine max / Q000201:enzymology; D013451:Sulfonic Acids / Q000737:chemistry; D014479:United Arab Emirates; D019207:beta Carotene / Q000737:chemistry
chemical_list: D052160:Benzothiazoles; D001713:Biphenyl Compounds; D016166:Free Radical Scavengers; D056572:Histone Deacetylase Inhibitors; D016859:Lipoxygenase Inhibitors; D010851:Picrates; D010936:Plant Extracts; D010940:Plant Proteins; D059808:Polyphenols; D012997:Solvents; D013451:Sulfonic Acids; D019207:beta Carotene; C002502:2,2'-azino-di-(3-ethylbenzothiazoline)-6-sulfonic acid; D000431:Ethanol; C004931:1,1-diphenyl-2-picrylhydrazyl; D008084:Lipoxygenase; D006655:Histone Deacetylases