title: Pd-catalyzed imine cyclization: synthesis of antimalarial natural products Aplidiopsamine A, Marinoquinoline A, and their potential hybrid NCLite-M1.
abstract: Palladium-catalyzed cyclization of imines has been developed to construct the extremely rare 3H-pyrrolo[2,3-c]quinoline ring system for diversity oriented first total synthesis of antimalarial marine natural product Aplidiopsamine A as well as synthesis of Marinoquinoline A and potential natural product hybrid NCLite-M1.
authors.affiliation: Division of Organic Chemistry, National Chemical Laboratory (CSIR-NCL), Pune 411 008, India.
authors.forename: Jyoti P
authors.initials: JP
authors.lastname: Mahajan
authors.forename: Yogeshwar R
authors.initials: YR
authors.lastname: Suryawanshi
authors.forename: Santosh B
authors.initials: SB
authors.lastname: Mhaske
mesh_terms: D000818:Animals; D000962:Antimalarials / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D001688:Biological Products / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D002384:Catalysis; D020650:Combinatorial Chemistry Techniques; D003500:Cyclization; D008386:Marine Biology; D015394:Molecular Structure; D010165:Palladium / Q000737:chemistry*; D011758:Pyrroles / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D011804:Quinolines / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology
chemical_list: D000962:Antimalarials; D001688:Biological Products; D011758:Pyrroles; D011804:Quinolines; C555847:aplidiopsamine A; C558971:marinoquinoline A; D010165:Palladium