title: Functional aspects of neuroprotective effects of new salts and compositions of baclofen in the convulsive syndrome caused by electroshock.
abstract: New salts of baclofen (4-amino-3-(para-chlorophenyl)-butyric acid) and its compositions with organic carbonic acids (citric, succinic, malic, oxalic, nicotinic, glutamic acids and glycine) exhibited neuroprotective and anticonvulsive effects. They reduced the intensity of the convulsive syndrome and postconvulsive psychoneurological disorders in animals exposed to the maximum electroshock and electroconvulsive shock. Analogs of baclofen containing citrate and to a lesser extent those containing glutamate and glycine were significantly more active than the initial substance.
authors.affiliation: Volgograd State Medical University, Russia.
authors.forename: I N
authors.initials: IN
authors.lastname: Tyurenkov
authors.forename: L E
authors.initials: LE
authors.lastname: Borodkina
authors.forename: V V
authors.initials: VV
authors.lastname: Bagmetova
mesh_terms: D000818:Animals; D001418:Baclofen / Q000737:chemistry / Q000494:pharmacology*; D002264:Carboxylic Acids / Q000378:metabolism; D004558:Electric Stimulation; D004597:Electroshock / Q000009:adverse effects*; D008297:Male; D018696:Neuroprotective Agents / Q000494:pharmacology*; D051381:Rats; D012492:Salts / Q000378:metabolism*; D012640:Seizures / Q000188:drug therapy* / Q000209:etiology*; D018709:Statistics, Nonparametric; D016896:Treatment Outcome
chemical_list: D002264:Carboxylic Acids; D018696:Neuroprotective Agents; D012492:Salts; D001418:Baclofen