title: [Trends in the risk factors and signs of subclinical atherosclerosis in subjects at low and moderate risk according to the SCORE scale in different medical management tactics: two-year follow-up results].
abstract: OBJECTIVE
  To comparatively analyze the following parameters of the subclinical manifestations of atherosclerosis: carotid intima-media thickness (IMT), the presence and number of carotid atherosclerotic plaques (ASP), ankle brachial pulse wave velocity (ABPWV) in patients from 2 (active and conventional observation) groups at low and moderate risks according to the SCORE scale in two-year outpatient practice.
  
  
  METHODS
  A screening could select 600 able-bodied persons (445 women and 155 men) aged 30 to 65 years at low and moderate risks (according to the SCORE scale without atherosclerosis-associated diseases who were divided into 2 groups: A) active observation (n =400) and B) conventional medical management tactics (n = 200). Five hundred and seven (85%) persons (339 in Group A and 168 in Group B) completed the study following 2 years. Carotid duplex scanning, computed sphygmography, and biochemical tests for blood lipid composition were performed. The delta index (%) calculated by the special formula, by subtracting the results during the first visit from those obtained 2 years later, was used to statistically analyze the time course of changes in the parameters under study.
  
  
  RESULTS
  Delta IMT (%) statistically significantly increased in Group B men as compared to that in Group A men (p = 0.042). The delta parameter of total carotid stenosis, which reflected the percentage of the latter, proved to be high in both Group B women and men (p = 0.0001) and the persons with a larger number of ASP were statistically significantly more in Group B (p = 0.035). Delta ABPWV (%) was also greater in Group B (p = 0.001).
  
  
  CONCLUSIONS
  Just after 2 years, the active medical observation tactics in patients at low and moderate risks (according to the SCORE scale) can result in a reduction in the rate of subclinical atherosclerosis progression in the carotid artery.
authors.forename: S Zh
authors.initials: SZh
authors.lastname: Urazalina
authors.forename: S A
authors.initials: SA
authors.lastname: Boĭtsov
authors.forename: T V
authors.initials: TV
authors.lastname: Balakhonova
authors.forename: V V
authors.initials: VV
authors.lastname: Kukharchuk
authors.forename: Iu A
authors.initials: IuA
authors.lastname: Karpov
mesh_terms: D000328:Adult; D000368:Aged; D000553:Ambulatory Care / Q000379:methods*; D055109:Ankle Brachial Index; D002340:Carotid Artery Diseases / Q000503:physiopathology* / Q000628:therapy; D059168:Carotid Intima-Media Thickness; D018450:Disease Progression; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008055:Lipids / Q000097:blood*; D008297:Male; D008875:Middle Aged; D058226:Plaque, Atherosclerotic / Q000473:pathology*; D012307:Risk Factors; D013997:Time Factors
chemical_list: D008055:Lipids