title: Mucormycosis-associated intracranial hemorrhage.
abstract: Rhinoorbitocerebral mucormycosis is a devastating infection being increasingly recognized in immunocompromised hosts and carries poor prognosis. Early recognition and treatment are critical in order to improve clinical outcomes and decrease the development of complications. Fatal cerebral infarctions have been described in patients with rhinoorbitocerebral mucormycosis, likely due to the thrombotic occlusion of the affected blood vessels directly invaded by this aggressive mycotic infection. We report a patient that presented with aplastic anemia, subsequently complicated by systemic mucormycosis, which generated reactive plasmacytosis, and developed intracranial infarction and hemorrhage.
authors.affiliation: Department of Hematology and Oncology, Henry Ford Hospital, Detroit, Michigan, USA. Javier.munoz@me.com
authors.forename: Javier
authors.initials: J
authors.lastname: Munoz
authors.forename: Amy
authors.initials: A
authors.lastname: Hughes
authors.forename: Yue
authors.initials: Y
authors.lastname: Guo
mesh_terms: D000305:Adrenal Cortex Hormones / Q000009:adverse effects / Q000627:therapeutic use; D000741:Anemia, Aplastic / Q000188:drug therapy / Q000209:etiology / Q000473:pathology; D001853:Bone Marrow / Q000473:pathology; D002544:Cerebral Infarction / Q000000981:diagnostic imaging / Q000209:etiology* / Q000382:microbiology; D057210:Delayed Diagnosis; D003937:Diagnosis, Differential; D004844:Epistaxis / Q000150:complications; D017809:Fatal Outcome; D006801:Humans; D025301:Hyphae / Q000302:isolation & purification; D016867:Immunocompromised Host; D007166:Immunosuppressive Agents / Q000009:adverse effects / Q000627:therapeutic use; D020300:Intracranial Hemorrhages / Q000000981:diagnostic imaging / Q000209:etiology* / Q000382:microbiology; D008297:Male; D008875:Middle Aged; D009091:Mucormycosis / Q000150:complications*; D009894:Opportunistic Infections / Q000150:complications*; D010265:Paraproteinemias / Q000175:diagnosis; D010950:Plasma Cells / Q000473:pathology; D016553:Purpura, Thrombocytopenic, Idiopathic / Q000150:complications / Q000188:drug therapy; D018805:Sepsis / Q000209:etiology; D014057:Tomography, X-Ray Computed; D014781:Viscera / Q000382:microbiology / Q000473:pathology
chemical_list: D000305:Adrenal Cortex Hormones; D007166:Immunosuppressive Agents