title: Expression and function of dectin-1 is defective in monocytes from patients with systemic lupus erythematosus and rheumatoid arthritis.
abstract: The aim of this work was to study the expression and function of the innate immune receptor dectin-1 in patients with systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA). We studied twenty-six patients with SLE not receiving immunosuppressive therapy, twenty-six patients with RA, and fifteen controls. We found that monocytes from SLE patients showed a diminished expression of dectin-1 compared to healthy controls, and an inverse correlation between percent of dectin-1(+) cells and the disease activity score was detected. In addition, cells from SLE patients showed an abnormal calcium flux response induced by dectin-1 ligands as well as an enhanced release of IL-1β, IL-6 and TNF-α, but not IL-23, upon dectin-1 engagement. Monocytes from patients with RA also showed a diminished expression, and a defective function of dectin-1. Our data suggest that dectin-1 receptor defects could contribute to the pathogenesis of autoimmune inflammatory conditions.
authors.affiliation: Department of Immunology, Facultad de Medicina, UASLP, San Luis Potosí, SLP, Mexico.
authors.forename: Claudia
authors.initials: C
authors.lastname: Salazar-Aldrete
authors.forename: Marta
authors.initials: M
authors.lastname: Galán-Díez
authors.forename: Elena
authors.initials: E
authors.lastname: Fernández-Ruiz
authors.forename: Perla
authors.initials: P
authors.lastname: Niño-Moreno
authors.forename: Lizbeth
authors.initials: L
authors.lastname: Estrada-Capetillo
authors.forename: Carlos
authors.initials: C
authors.lastname: Abud-Mendoza
authors.forename: Esther
authors.initials: E
authors.lastname: Layseca-Espinosa
authors.forename: Lourdes
authors.initials: L
authors.lastname: Baranda
authors.forename: Roberto
authors.initials: R
authors.lastname: González-Amaro
mesh_terms: D000328:Adult; D001172:Arthritis, Rheumatoid / Q000235:genetics / Q000276:immunology / Q000378:metabolism*; D016207:Cytokines / Q000096:biosynthesis; D005260:Female; D005786:Gene Expression Regulation; D006801:Humans; D016130:Immunophenotyping; D037181:Lectins, C-Type / Q000235:genetics / Q000378:metabolism*; D008180:Lupus Erythematosus, Systemic / Q000235:genetics / Q000378:metabolism*; D008297:Male; D009000:Monocytes / Q000276:immunology / Q000378:metabolism*; D055815:Young Adult; D000099181:Dectin-1
chemical_list: D016207:Cytokines; D037181:Lectins, C-Type; D000099181:Dectin-1