title: Outcome of triple-negative breast cancer in patients with or without markers regulating cell cycle and cell death.
abstract: OBJECTIVE
  The genes p53 and B-cell lymphoma (bcl)-2 play an important role in regulating the mechanisms of apoptosis. In this paper, we retrospectively applied these factors to our series of triple negative breast cancer (TNBC) patients, in conjunction with an evaluation of the prognostic significance of these factors' influence on TNBC survival rate. Particular focus was placed on the role of bcl-2, p53, Ki-67.
  
  
  METHODS
  The study subjects, 94 women with TNBC, were a subset of patients operated at Kosin University Gospel Hospital from January 2000 to December 2005. Chi-squared tests were used for statistical analysis.
  
  
  RESULTS
  Positive staining for cytokeratin (CK)5/6 in 23 cases (24.5%), epidermal growth factor receptor in 15 cases (16.0%), bcl-2 in 26 cases (27.7%), p53 in 55 cases (58.5%) and Ki-67 in 74 cases (78.7%) was determined. Lymph node status, tumor size and expression of CK5/6 or Ki-67 were independent prognostic factors for patients with TNBC.
  
  
  CONCLUSIONS
  Markers regulating cell cycle and cell death such as p53 and bcl-2 cannot be used to classify TNBCs into two subtypes with differing disease-free survival. But because our study is small in size, more abundant patient data will be needed to evaluate the factors' predictive role in regulating cell cycle and cell death.
authors.affiliation: Department of Surgery, Kosin University Gospel Hospital, Busan, Korea.
authors.forename: Dong Won
authors.initials: DW
authors.lastname: Ryu
authors.forename: Chung Han
authors.initials: CH
authors.lastname: Lee
keywords: Ki-67; Triple negative; bcl-2; p53