title: Adenosine deaminase and C-reactive protein in cerebrospinal fluid for differential diagnosis of tubercular meningitis in children.
abstract: Adenosine deaminase and C-reactive protein in CSF were assessed in 72 cases of Tubercular meningitis, 24 cases of partially treated pyogenic meningitis, 20 cases of Aseptic meningitis and 8 cases of febrile seizures. Mean Adenosine deaminase value was 12.12±3.13 IU/L for Tubercular meningitis group. It was significantly higher (p<0.001) as compared to partially treated pyogenic meningitis (5.39±2.70 IU/L) and aseptic meningitis (1.92±0.56 IU/L) groups. A combination of clinical criteria along with biochemical test of Adenosine deaminase and C-reactive protein in CSF increased the sensitivity of diagnosing Tubercular meningitis and differentiating it from other forms of meningitis at an early stage.
authors.affiliation: Department of Pediatric Gastroenterology, SGPGIMS, Lucknow, India.
authors.forename: Shrish
authors.initials: S
authors.lastname: Bhatnagar
authors.forename: Farzana K
authors.initials: FK
authors.lastname: Beig
authors.forename: Ashraf
authors.initials: A
authors.lastname: Malik
keywords: Adenosine deaminase and C-reactive protein in CSF; Children; Tubercular meningitis