title: Evaluation of Urine Cytology in Urothelial Carcinoma Patients: A Comparison of CellprepPlus® Liquid-Based Cytology and Conventional Smear.
abstract: BACKGROUND
  Urine cytology is an important test in the screening of urothlelial neoplasms. The conventional smear (CS) method of testing urine samples has a low sensitivity, approximately 50% result accuracy for detecting urothelial carcinomas, while liquid-based cytology (LBC) has much improved diagnostic accuracy, sensitivity, and specificity. The aim of this study was to compare the morphologic features and diagnostic efficacy of CellprepPlus® LBC with those of CS for urine cytology.
  
  
  METHODS
  A total of 713 cases of urine specimens collected from November 2009 to September 2010 were included. All specimens were divided equally for the preparation of CellprepPlus® LBC and CS for each case.
  
  
  RESULTS
  CellprepPlus® revealed more cellularity, a cleaner background and better cytomorphologic features, but it showed a less intact architectural pattern compared to that of CS. Of the 88 histologically confirmed cases, the diagnostic sensitivity for CellprepPlus® was 50% and higher than the 37.5% for CS. The specificity of both preparations was 100%.
  
  
  CONCLUSIONS
  The CellprepPlus® showed an improved quality of slides and provided better diagnostic accuracy, thus CellprepPlus® could be a first-line screening tool in urinary tract cytology.
authors.affiliation: Department of Pathology, Chungbuk National University College of Medicine, Cheongju, Korea.
authors.forename: Seung-Myoung
authors.initials: SM
authors.lastname: Son
authors.forename: Ji Hae
authors.initials: JH
authors.lastname: Koo
authors.forename: Song-Yi
authors.initials: SY
authors.lastname: Choi
authors.forename: Ho-Chang
authors.initials: HC
authors.lastname: Lee
authors.forename: Yong-Moon
authors.initials: YM
authors.lastname: Lee
authors.forename: Hyung Geun
authors.initials: HG
authors.lastname: Song
authors.forename: Hae-Kyung
authors.initials: HK
authors.lastname: Hwang
authors.forename: Hye-Suk
authors.initials: HS
authors.lastname: Han
authors.forename: Seok-Joong
authors.initials: SJ
authors.lastname: Yun
authors.forename: Wun-Jae
authors.initials: WJ
authors.lastname: Kim
authors.forename: Eun-Joong
authors.initials: EJ
authors.lastname: Kim
authors.forename: Ok-Jun
authors.initials: OJ
authors.lastname: Lee
keywords: Carcinoma, urothelial; Urinary bladder neoplasms; Urine, cytology