title: [Continuous glucose monitoring in glimipiride plus metformin treated type 2 diabetic patients during the month of Ramadan].
abstract: BACKGROUND
  Fasting during Ramadan may be a cause of poor glycaemic control in diabetic patients.
  
  
  OBJECTIVE
  To assess glucose excursions during Ramadan by using a continuous glucose monitoring system (CGMS).
  
  
  METHODS
  The interstitial glucose level was recorded over 72 hours during Ramadan and three months later, in five type 2 diabetic patients, aged 56 ± 5, treated with glimepiride and metformin.
  
  
  RESULTS
  During Ramadan, four patients experienced at least one episode of low glucose level (<0.7 g/l) during the monitoring. The frequency of these episodes was 0.6 episode/d with an average duration of 36 mn / d. These episodes occurred in the morning in half of the cases and in the hour before breaking the fast in 37.5 % of the cases. Four patients experienced at least one episode of high glucose level (>1.8 g/l), with an average duration of 403 mn /d and with a frequency of two episodes /d. More than half episodes (53) occurred after the breaking of the fast. After Ramadan, CGM records showed at least one episode of low glucose in two patients with an average duration of 58 mn /d and a frequency of 1.3 episodes/d. Three patients experienced at least one episode of high glucose level with an average duration of 525 mn /d and a frequency of 1.46 episodes/day.
  
  
  CONCLUSIONS
  The blood glucose profile of our patients during Ramadan is characterized by important glycaemic excursions.
authors.affiliation: Service d'Endocrinologie de diabetologie et des maladies metaboliques, Institut national de Nutrition de Tunis, Tunisie.
authors.forename: Ibtissem
authors.initials: I
authors.lastname: Oueslati
authors.forename: Rania
authors.initials: R
authors.lastname: Ben Said
authors.forename: Ines
authors.initials: I
authors.lastname: Kammoun
authors.forename: Emna
authors.initials: E
authors.lastname: Haouat
authors.forename: Leila
authors.initials: L
authors.lastname: Ben Salem
authors.forename: Zinet
authors.initials: Z
authors.lastname: Turki
authors.forename: Claude
authors.initials: C
authors.lastname: Ben Slama
mesh_terms: D001786:Blood Glucose / Q000032:analysis*; D003924:Diabetes Mellitus, Type 2 / Q000097:blood* / Q000188:drug therapy*; D004359:Drug Therapy, Combination; D005215:Fasting; D005260:Female; D006801:Humans; D007004:Hypoglycemic Agents / Q000627:therapeutic use; D007514:Islam; D008297:Male; D008687:Metformin / Q000627:therapeutic use; D008875:Middle Aged; D018670:Monitoring, Ambulatory; D013453:Sulfonylurea Compounds / Q000627:therapeutic use; D014416:Tunisia
chemical_list: D001786:Blood Glucose; D007004:Hypoglycemic Agents; D013453:Sulfonylurea Compounds; C057619:glimepiride; D008687:Metformin