title: Antihyperglycemic effect of water extract of dry fruits ofTerminalia chebula in experimental diabetes mellitus.
abstract: Water extract of dry fruits ofTerminalia chebula (Hindi-Harda, Telugu-Karakkaya) at a dose of 200 mg/kg body weight improved the glucose tolerance as indicated by 44% of reduction in the peak blood glucose at 2(nd) hour in glucose tolerance test in diabetic (streptozotocin induced) rats. Treatment of diabetic rats with an initial fasting blood glucose of 253±9.4 mg/dl daily once with the water extract (200 mg/kg) for two weeks brought down the fasting blood glucose to 123±8.4 mg/dl which is only slightly above the normal value. These results indicate that water extract of Terminalia chebula improves glucose tolerance and brings down fasting blood glucose in diabetic rats.
authors.affiliation: Dr B.R. Ambedkar Center for Biomedical Research, University of Delhi, 110007 Delhi.
authors.forename: Y K
authors.initials: YK
authors.lastname: Murali
authors.forename: Ramesh
authors.initials: R
authors.lastname: Chandra
authors.forename: P S
authors.initials: PS
authors.lastname: Murthy
keywords: Antihyperglycemic effect; Diabetes mellitus; Glucose tolerance; Terminalia chebula