title: Facile functionalization of polyesters through thiol-yne chemistry for the design of degradable, cell-penetrating and gene delivery dual-functional agents.
abstract: Synthesis of polyesters bearing pendant amine groups with controlled molecular weights and narrow molecular weight distributions was achieved through ring-opening polymerization of 5-(4-(prop-2-yn-1-yloxy)benzyl)-1,3-dioxolane-2,4-dione, an O-carboxyanhydride derived from tyrosine, followed by thiol-yne "click" photochemistry with 2-aminoethanethiol hydrochloride. This class of biodegradable polymers displayed excellent cell penetration and gene delivery properties with low toxicities.
authors.affiliation: Department of Materials Science and Engineering, University of Illinois at Urbana-Champaign, 1304 West Green Street, Urbana, IL 61801, USA.
authors.forename: Zhonghai
authors.initials: Z
authors.lastname: Zhang
authors.forename: Lichen
authors.initials: L
authors.lastname: Yin
authors.forename: Yunxiang
authors.initials: Y
authors.lastname: Xu
authors.forename: Rong
authors.initials: R
authors.lastname: Tong
authors.forename: Yanbing
authors.initials: Y
authors.lastname: Lu
authors.forename: Jie
authors.initials: J
authors.lastname: Ren
authors.forename: Jianjun
authors.initials: J
authors.lastname: Cheng
mesh_terms: D000588:Amines / Q000737:chemistry; D001692:Biological Transport; D045744:Cell Line, Tumor; D018014:Gene Transfer Techniques; D006367:HeLa Cells; D006801:Humans; D011091:Polyesters / Q000138:chemical synthesis* / Q000737:chemistry*; D058105:Polymerization; D013438:Sulfhydryl Compounds / Q000737:chemistry
chemical_list: D000588:Amines; D011091:Polyesters; D013438:Sulfhydryl Compounds