title: Successful treatment of liver aspergilloma by caspofungin acetate first-line therapy in a non-immunocompromised patient.
abstract: Aspergillosis remains to be a life-threatening complication in immunocompromised patients. However, Aspergillus infection can be observed in non-immunocompromised individuals in rare cases. We report a case of liver aspergilloma in a chronic aplastic anemia patient under relatively intact immune status. Therapeutic strategy for this rare condition was extensively discussed and caspofungin acetate single agent first-line therapy was applied after careful consideration. Encouraging clinical and radiologic improvements were achieved in response to the antifungal salvage. Our long-term follow-up study also revealed a favorable prognosis. Based on this experience, we suggest caspofungin acetate as first-line therapy for treatment plans of liver aspergilloma.
authors.affiliation: Department of Hematology, State Allogeneic Hematopoietic Stem Cell Transplantation Center, Xijing Hospital, Fourth Military Medical University, Xi'an 710032, China.
authors.forename: Qing-Xian
authors.initials: QX
authors.lastname: Bai
authors.affiliation: Department of Radiology and Medical Imaging Center, Xijing Hospital, Fourth Military Medical University, Xi'an 710032, China.
authors.forename: Yi
authors.initials: Y
authors.lastname: Huan
authors.affiliation: Department of Hematology, State Allogeneic Hematopoietic Stem Cell Transplantation Center, Xijing Hospital, Fourth Military Medical University, Xi'an 710032, China.
authors.forename: Jian-Hong
authors.initials: JH
authors.lastname: Wang
authors.affiliation: Department of Hematology, State Allogeneic Hematopoietic Stem Cell Transplantation Center, Xijing Hospital, Fourth Military Medical University, Xi'an 710032, China.
authors.forename: Li-Jie
authors.initials: LJ
authors.lastname: Yang
authors.affiliation: Department of Hematology, State Allogeneic Hematopoietic Stem Cell Transplantation Center, Xijing Hospital, Fourth Military Medical University, Xi'an 710032, China.
authors.forename: Hong-Juan
authors.initials: HJ
authors.lastname: Dong
mesh_terms: D000741:Anemia, Aplastic / Q000150:complications; D000935:Antifungal Agents / Q000627:therapeutic use*; D001228:Aspergillosis / Q000150:complications / Q000175:diagnosis / Q000188:drug therapy*; D001232:Aspergillus fumigatus / Q000302:isolation & purification*; D000077336:Caspofungin; D054714:Echinocandins / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D055666:Lipopeptides; D008099:Liver / Q000000981:diagnostic imaging / Q000382:microbiology*; D008875:Middle Aged; D011859:Radiography
chemical_list: D000935:Antifungal Agents; D054714:Echinocandins; D055666:Lipopeptides; D000077336:Caspofungin
keywords: Aspergillus fumigatus; aspergillosis; caspofungin acetate; liver