title: Haplotype study of the CYP4A11 gene and coronary artery disease in Han and Uygur populations in China.
abstract: BACKGROUND
  CYP4A11 converts arachidonic acid to 20-hydroxyeicosatetraenoic acid (20-HETE), which has a crucial role in the modulation of cardiovascular homeostasis. We assessed the association between the human CYP4A11 gene and coronary artery disease (CAD) in Han and Uygur populations in China.
  
  
  RESULTS
  In the Han population, 361 CAD patients and 315 controls were genotyped for four single-nucleotide polymorphisms (SNPs) of the human CYP4A11 gene (rs9332978, rs4660980, rs3890011, rs1126742). In the Uygur population, 331 CAD patients and 182 controls were genotyped for the same four SNPs. Data were assessed via haplotype-based case-control studies. For the Han population, the significance of the recessive model of SNP3 (GG vs. CC+GC) between CAD patients and control subjects was retained after adjustment for EH, DM and smoking (for men, 95% CI: 1.173-3.013, P=0.009). The G-G-T haplotype in CAD was significantly higher than that in the control group (P=0.037). In the Uygur population, neither the distribution of genotypes and alleles for the four SNPs nor the distribution of haplotypes constructed with the same three SNPs showed a significant difference between CAD and control subjects.
  
  
  CONCLUSIONS
  The GG genotype of rs3890011 and the G-G-T haplotype in the CYP4A11 gene could be a useful genetic marker of CAD in Han populations in China.
authors.affiliation: Department of Cardiovascular Medicine, First Affiliated Hospital of Xinjiang Medical University, Urumqi, China.
authors.forename: Zhenyan
authors.initials: Z
authors.lastname: Fu
authors.forename: Hong
authors.initials: H
authors.lastname: Yang
authors.forename: Yitong
authors.initials: Y
authors.lastname: Ma
authors.forename: Ding
authors.initials: D
authors.lastname: Huang
authors.forename: Xiang
authors.initials: X
authors.lastname: Xie
authors.forename: Yingying
authors.initials: Y
authors.lastname: Zheng
authors.forename: Qing
authors.initials: Q
authors.lastname: Zhu
authors.forename: Tomohiro
authors.initials: T
authors.lastname: Nakayama
mesh_terms: D000328:Adult; D000368:Aged; D044466:Asian People; D016022:Case-Control Studies; D002681:China / Q000453:epidemiology / Q000208:ethnology; D003324:Coronary Artery Disease / Q000453:epidemiology / Q000208:ethnology* / Q000235:genetics*; D042926:Cytochrome P-450 CYP4A; D003577:Cytochrome P-450 Enzyme System / Q000235:genetics*; D005260:Female; D005838:Genotype; D006239:Haplotypes; D006801:Humans; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide
chemical_list: D003577:Cytochrome P-450 Enzyme System; C465478:CYP4A11 protein, human; D042926:Cytochrome P-450 CYP4A