title: Endoscopic ultrasound-guided fine needle aspiration cytology diagnosis of solid pseudopapillary neoplasm: three case reports with review of literature.
abstract: Solid pseudopapillary neoplasm of the pancreas (SPN) is relatively rare and it occurs almost exclusively in women. We recently experienced three cases of SPN diagnosed by endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA). These three cases were two male and one female patient whose age was 29, 37, and 44 years old. Radiological diagnosis was pancreatic endocrine tumor (PEN) showing solid with a heterogenous echogenicity. EUS-FNA cytology specimens consisted of single cells and aggregates of uniform cells, forming microadenoid structures, branching, papillary clusters with delicate fibrovascular cores. In conclusion, a single diagnosis of SPN based on clinical and radiological findings would be risky because there is a possibility of it being misdiagnosed as PEN or other malignancies. An EUS-FNA is therefore essential for establishing the diagnosis. In addition, the pathologists should recognize the characteristic cytologic findings with immunoprofiles of SPN to prevent misdiagnosis of SPN.
authors.affiliation: Department of Pathology, Center for Liver Cancer, National Cancer Center, Goyang, Korea. ; Department of Pathology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
authors.forename: Joon Seon
authors.initials: JS
authors.lastname: Song
authors.forename: Chong Woo
authors.initials: CW
authors.lastname: Yoo
authors.forename: Youngmee
authors.initials: Y
authors.lastname: Kwon
authors.forename: Eun Kyung
authors.initials: EK
authors.lastname: Hong
keywords: Cytology; Endoscopic ultrasound-guided fine needle aspiration; Solid pseudopapillary neoplasm