title: Sleep-disordered breathing and childhood asthma:  clinical implications.
abstract: OBJECTIVE
  Asthma morbidity in children remains high despite comprehensive evidence-based guidelines for evaluation and treatment. The objective of this review is to examine the evidence that obstructive sleep-disordered breathing often co-exists with asthma and is associated with asthma severity, and to discuss the clinical implications of this relationship, focusing particularly on studies published within the past year.
  
  
  RESULTS
  Obstructive sleep-disordered breathing is highly prevalent in children with severe or poorly controlled asthma. Data from an observational study suggest that adenotonsillectomy markedly improves asthma outcomes in children with poorly controlled asthma and comorbid obstructive sleep apnea.
  
  
  CONCLUSIONS
  Clinicians should consider evaluating and treating obstructive sleep-disordered breathing in children with severe or difficult-to-control asthma. Further controlled studies are needed to confirm that treatment of obstructive sleep apnea improves pediatric asthma outcomes, and to extend our understanding of how asthma and sleep-disordered breathing interact.
authors.affiliation: Pediatric Pulmonology, Rainbow Babies and Children's Hospital, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106, USA. Kristie.ross@uhhospitals.org
authors.forename: Kristie
authors.initials: K
authors.lastname: Ross
mesh_terms: D000234:Adenoids / Q000601:surgery; D000293:Adolescent; D001249:Asthma / Q000453:epidemiology*; D002648:Child; D002675:Child, Preschool; D015897:Comorbidity; D006801:Humans; D014066:Palatine Tonsil / Q000601:surgery; D015995:Prevalence; D012720:Severity of Illness Index; D012891:Sleep Apnea Syndromes / Q000453:epidemiology*; D020181:Sleep Apnea, Obstructive / Q000453:epidemiology*