title: Efficacy prediction of jamu formulations by PLS modeling.
abstract: Indonesian herbal medicines made from mixtures of several plants are called "Jamu." The efficacy of a particular Jamu is determined by its ingredients i.e. the composition of the plants. Thus, we modeled the ingredients of Jamu formulas using Partial Least Squares Discriminant Analysis (PLS-DA) in order to predict their efficacy. The plants used in each Jamu medicine served as the predictors, whereas the efficacy of each Jamu provided the responses. Utilizing response predictions obtained from PLS-DA, we predicted the efficacies of Jamu formulations using two methods: maximum response prediction and maximum probability. In predictions of Jamu efficacy, the maximum response prediction method produced a smaller error than that the maximum probability method. Furthermore, utilizing the PLS-DA coefficient matrix, we determined the efficacy for which a plant is most useful, based on its largest coefficients.
authors.affiliation: Graduate School of Information Science, Nara Institute of Science and Technology, Ikoma, Nara, Japan. farit-a@is.naist.jp
authors.forename: Farit M
authors.initials: FM
authors.lastname: Afendi
authors.forename: Latifah K
authors.initials: LK
authors.lastname: Darusman
authors.forename: Aki Hirai
authors.initials: AH
authors.lastname: Morita
authors.forename: Md
authors.initials: M
authors.lastname: Altaf-Ul-Amin
authors.forename: Hiroki
authors.initials: H
authors.lastname: Takahashi
authors.forename: Kensuke
authors.initials: K
authors.lastname: Nakamura
authors.forename: Ken
authors.initials: K
authors.lastname: Tanaka
authors.forename: Shigehiko
authors.initials: S
authors.lastname: Kanaya
mesh_terms: D016002:Discriminant Analysis; D006801:Humans; D007214:Indonesia; D016018:Least-Squares Analysis; D008954:Models, Biological; D028321:Plant Preparations / Q000737:chemistry* / Q000494:pharmacology*; D010946:Plants, Medicinal / Q000737:chemistry*
chemical_list: D028321:Plant Preparations