title: High mobility group B1 levels in sepsis and Disseminated Intravascular Coagulation.
abstract: Cytokines trigger coagulant and fibrinolytic systems in sepsis to result in Disseminated Intravascular Coagulation (DIC) that is an important complication and leads to disseminated hemorrhages and multi-organ failure. High Mobility Group B1 DNA Binding (HMGB1) protein is a cytokine taking part in systemic inflammatory response. The objective of this study was to investigate HMGB1 levels in groups of septic patients with and without DIC.Twenty-one septic patients without DIC and 12 septic patients with DIC from the Intensive Care Unit (ICU) were included in the study. In addition, 20 patients admitted to the ICU without sepsis or DIC and 20 healthy volunteers served as controls. Levels of HMGB1, prothrombin time, activated partial thromboplastin time, fibrinogen, D-dimer, protein C, protein S, anti-thrombin III (ATIII), platelet (thrombocyte) and leukocyte count were determined. Levels of fibrinogen, protein C, ATIII and platelet count were significantly lower and D-dimer was significantly higher in the group with sepsis plus DIC compared to the group with sepsis without DIC. Levels of HMGB1 were higher in the group with sepsis and DIC compared to the group with sepsis; however, the difference was not statistically significant and the levels of HGMB1 of both groups were significantly higher compared to ICU and healthy control groups. HMGB1 levels were not significantly different in survivor and non survivor patients. HMGB1 levels did not differ in lower respiratory tract infection (LRTI) and urinary tract infection (UTI) in regard to the etiology of sepsis.
authors.affiliation: Department of Biochemistry, Zonguldak Karaelmas University, Faculty of Medicine, Esenköy-Kozlu-Zonguldak, Turkey.
authors.forename: Zeynep M
authors.initials: ZM
authors.lastname: Eskici
authors.forename: Şerefden
authors.initials: Ş
authors.lastname: Açıkgöz
authors.forename: Nihal
authors.initials: N
authors.lastname: Pişkin
authors.forename: Görkem
authors.initials: G
authors.lastname: Mungan
authors.forename: Murat
authors.initials: M
authors.lastname: Can
authors.forename: Berrak
authors.initials: B
authors.lastname: Güven
authors.forename: Fürüzan
authors.initials: F
authors.lastname: Köktürk
mesh_terms: D000328:Adult; D001780:Blood Coagulation Tests; D004211:Disseminated Intravascular Coagulation / Q000097:blood / Q000150:complications / Q000503:physiopathology; D005260:Female; D005340:Fibrinogen / Q000032:analysis; D024243:HMGB1 Protein / Q000097:blood / Q000378:metabolism; D006801:Humans; D007362:Intensive Care Units; D008297:Male; D008875:Middle Aged; D009102:Multiple Organ Failure / Q000150:complications / Q000378:metabolism; D011379:Prognosis; D017293:Protein S / Q000032:analysis; D011517:Prothrombin Time; D018805:Sepsis / Q000097:blood / Q000150:complications / Q000503:physiopathology; D013917:Thrombin / Q000032:analysis
chemical_list: D024243:HMGB1 Protein; D017293:Protein S; D005340:Fibrinogen; D013917:Thrombin