title: Peripapillary retinal nerve fiber layer thickness in children with iron deficiency anemia.
abstract: OBJECTIVE
  To evaluate peripapillary retinal nerve fiber layer (RNFL) thickness in children with iron deficiency anemia (IDA) in comparison with healthy controls and to investigate the correlation between peripapillary RNFL thicknesses and the hematologic parameters in these subjects.
  
  
  METHODS
  Forty eyes of 40 children with a diagnosis of IDA (anemic group) and 40 eyes of 40 age- and sex-matched healthy children (control group) were enrolled in this study. Peripapillary RNFL thickness measurements were performed using Cirrus HD optical coherence tomography (OCT).
  
  
  RESULTS
  Mean age of each group was 11.3±2.7 years. Average RNFL and RNFLs of superior and inferior quadrants were significantly thinner in the anemic group than in the control group (p=0.006, p=0.005, and p=0.005, respectively). In addition, average peripapillary RNFL thickness and RNFL thicknesses of superior, inferior, and temporal quadrants were correlated with hemoglobin levels (r1=0.734, p1<0.001, r2=0.456, p2=0.005, r3=0.598, p3<0.001, r4=0.349, p4=0.037, respectively) in anemic group. CONCLUSIONS. We found that children with IDA had different peripapillary RNFL profile measured by Cirrus HD spectral-domain OCT. We caution ophthalmologists when they measure RNFL thickness in children to diagnose glaucoma or other neuro-ophthalmic disorders.
authors.affiliation: Department of Ophthalmology, Recep Tayyip Erdogan University Medical School, Rize, Turkey.
authors.forename: Kemal
authors.initials: K
authors.lastname: Türkyilmaz
authors.forename: Veysi
authors.initials: V
authors.lastname: Oner
authors.forename: Serdar
authors.initials: S
authors.lastname: Ozkasap
authors.forename: Berrak
authors.initials: B
authors.lastname: Sekeryapan
authors.forename: Selim
authors.initials: S
authors.lastname: Dereci
authors.forename: Mustafa
authors.initials: M
authors.lastname: Durmus
mesh_terms: D000293:Adolescent; D018798:Anemia, Iron-Deficiency / Q000097:blood / Q000150:complications*; D002648:Child; D005260:Female; D005293:Ferritins / Q000097:blood; D006801:Humans; D058085:Iron Compounds / Q000097:blood; D033862:Iron-Binding Proteins / Q000378:metabolism; D008163:Luminescent Measurements; D008297:Male; D009412:Nerve Fibers / Q000473:pathology*; D009898:Optic Disk / Q000473:pathology*; D012165:Retinal Ganglion Cells / Q000473:pathology*; D041623:Tomography, Optical Coherence; D014168:Transferrin / Q000378:metabolism
chemical_list: D058085:Iron Compounds; D033862:Iron-Binding Proteins; D014168:Transferrin; D005293:Ferritins