title: Molecular neuropathogenesis of Alzheimer's disease: an interaction model stressing the central role of oxidative stress.
abstract: Alzheimer's disease (AD) exhibits a complex etiology that simultaneously manifests as a complex cellular, neurobiological, molecular, anatomic-physiological and clinical entity. Other significant psychiatric conditions, such as depression and schizophrenia, may also present with complex and concurrent clinical and/or molecular phenotypes. These neuropsychiatric pathologies also originate from both environmental and genetic factors. We analyzed the molecular phenotypes of AD and discuss them with respect to the classical theories, which we integrated into mechanisms that share molecular and/or anatomical connections. Based on these mechanisms, we propose an interaction model and discuss the model in light of studies that refute or support it. Given the spectrum of AD phenotypes, we limit the scope of our discussion to a few, which facilitates concrete analysis. In addition, the study of specific, individual pathogenic phenotypes may be critical to defining the complex mechanisms leading to AD, thereby improving strategies for developing novel therapies.
authors.affiliation: Ave. Icaraí Cristal 74 (Clinic), 90.810-000 Porto Alegre, Rio Grande do Sul (RS), Brazil.
authors.forename: Roberto
authors.initials: R
authors.lastname: Rodrigues
authors.forename: Mark A
authors.initials: MA
authors.lastname: Smith
authors.forename: Xinglong
authors.initials: X
authors.lastname: Wang
authors.forename: George
authors.initials: G
authors.lastname: Perry
authors.forename: Hyoung-Gon
authors.initials: HG
authors.lastname: Lee
authors.forename: Xiongwei
authors.initials: X
authors.lastname: Zhu
authors.forename: Robert B
authors.initials: RB
authors.lastname: Petersen