title: 7T μMRI of mesenteric venous ischemia in a rat model: timing of the appearance of findings.
abstract: OBJECTIVE
  The aim of this study is to analyze the chronological development of macroscopic, microscopic and magnetic resonance imaging (MRI) findings in a rat model of Superior Mesenteric Venous (SMV) ligation, and to evaluate the role of MRI in the diagnosis of mesenteric venous thrombosis.
  
  
  METHODS
  Thirty adult Sprague-Dawley rats were used and divided in two different groups that underwent a different surgical model and a different monitoring of ischemic damage. Group I underwent macroscopical and histological observation; Group II underwent 7T μMRI evaluation and histological analysis.
  
  
  RESULTS
  The first alterations occurred 30 min after SMV ligation and progressively worsened until the eighth hour. The morphological and MRI findings showed the same course.
  
  
  CONCLUSIONS
  This study provides a systematic evaluation of early anatomopathological and MRI findings following the SMV ligation. MRI allows to identify the early pathological findings of venous mesenteric ischemia and allows to correlate those to the histopathological features. Our data suggest a relevant role of MRI in the diagnostic management of mesenteric venous thrombosis, allowing to non-invasively identify and characterize the histopathologic findings. So, thanks to these skills, its future application in early diagnosis of human mesenteric venous ischemia is supposable.
authors.affiliation: Institute of Radiology, Second University of Naples, Piazza Miraglia 2, Naples, Italy.
authors.forename: Francesco
authors.initials: F
authors.lastname: Somma
authors.forename: Daniela
authors.initials: D
authors.lastname: Berritto
authors.forename: Francesca
authors.initials: F
authors.lastname: Iacobellis
authors.forename: Nicola
authors.initials: N
authors.lastname: Landi
authors.forename: Carlo
authors.initials: C
authors.lastname: Cavaliere
authors.forename: Marco
authors.initials: M
authors.lastname: Corona
authors.forename: Serena
authors.initials: S
authors.lastname: Russo
authors.forename: Roberto
authors.initials: R
authors.lastname: Di Mizio
authors.forename: Antonio
authors.initials: A
authors.lastname: Rotondo
authors.forename: Roberto
authors.initials: R
authors.lastname: Grassi
mesh_terms: D000818:Animals; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D007511:Ischemia / Q000473:pathology*; D018810:Magnetic Resonance Angiography / Q000379:methods*; D008297:Male; D008642:Mesenteric Veins / Q000473:pathology*; D008643:Mesentery / Q000098:blood supply* / Q000473:pathology*; D023421:Models, Animal; D051381:Rats; D017207:Rats, Sprague-Dawley; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D020246:Venous Thrombosis / Q000473:pathology*