title: Mycobacterium africanum, an emerging disease in high-income countries?
abstract: BACKGROUND
  Mycobacterium africanum is a cause of tuberculosis (TB) that has mainly been described in Africa, but immigration and travel patterns have contributed to the spread of the disease to other countries.
  
  
  METHODS
  We retrospectively reviewed TB cases due to M. africanum  during 2000-2010 in seven Spanish hospitals. Selected clinical charts were reviewed using a predefined protocol that included demographical, clinical and microbiological data and outcome.
  
  
  RESULTS
  Although 57 cases were diagnosed, only 36 clinical charts were available for review:  82.8% were men and the mean age was 31.6 years (range 12-81). Forty-four cases were from Africa, 1 from the Philippines, 1 from India, and 4 from Spain, while the country of origin was unknown in 7 cases. The most frequent site of infection was the lung (58.3%). Four cases (6.9%) were  resistant to at least one first-line anti-tuberculosis drug.
  
  
  CONCLUSIONS
  Disease due to M. africanum in industrialised countries is mainly associated with immigration from endemic areas, although some cases also occur among native-born populations.
authors.affiliation: Department of Clinical Microbiology, Instituto de Investigación Sanitaria de la Fundación Jiménez Díaz, Madrid, Spain.
authors.forename: M C
authors.initials: MC
authors.lastname: Isea-Peña
authors.forename: M F
authors.initials: MF
authors.lastname: Brezmes-Valdivieso
authors.forename: M C
authors.initials: MC
authors.lastname: González-Velasco
authors.forename: M A
authors.initials: MA
authors.lastname: Lezcano-Carrera
authors.forename: L
authors.initials: L
authors.lastname: López-Urrutia-Lorente
authors.forename: N
authors.initials: N
authors.lastname: Martín-Casabona
authors.forename: M L
authors.initials: ML
authors.lastname: Monforte-Cirac
authors.forename: J J
authors.initials: JJ
authors.lastname: Palacios
authors.forename: A
authors.initials: A
authors.lastname: Penedo-Pallares
authors.forename: A
authors.initials: A
authors.lastname: Ramirez-Rosales
authors.forename: R
authors.initials: R
authors.lastname: Sánchez-Silos
authors.forename: T
authors.initials: T
authors.lastname: Tórtola-Fernández
authors.forename: J
authors.initials: J
authors.lastname: Viñuelas-Bayón
authors.forename: A
authors.initials: A
authors.lastname: Vitoria-Agreda
authors.forename: J
authors.initials: J
authors.lastname: Esteban
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002648:Child; D019049:Developed Countries; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009017:Morbidity / Q000639:trends; D009161:Mycobacterium / Q000302:isolation & purification*; D009164:Mycobacterium Infections / Q000453:epidemiology* / Q000382:microbiology; D012189:Retrospective Studies; D013030:Spain / Q000453:epidemiology; D055815:Young Adult