title: Perioperative oxygen toxicity.
abstract: This article challenges the use of hyperoxia in the perioperative period. It describes the biochemical and physiologic basis for both the direct and indirect adverse effects of oxygen. The reasons for using hyperoxia in the perioperative period are critically evaluated, and the evidence and guidelines for oxygen use in common acute medical conditions are reviewed.
authors.affiliation: Department of Anaesthesia, St James's University Hospital, Leeds, United Kingdom. a.lumb@leeds.ac.uk
authors.forename: Andrew B
authors.initials: AB
authors.lastname: Lumb
authors.forename: Laura J
authors.initials: LJ
authors.lastname: Walton
mesh_terms: D000975:Antioxidants / Q000378:metabolism; D006801:Humans; D018496:Hyperoxia / Q000150:complications / Q000209:etiology / Q000503:physiopathology / Q000628:therapy; D061810:One-Lung Ventilation; D010100:Oxygen / Q000009:adverse effects* / Q000737:chemistry; D010102:Oxygen Inhalation Therapy / Q000009:adverse effects*; D019990:Perioperative Care; D001261:Pulmonary Atelectasis / Q000139:chemically induced / Q000628:therapy; D017382:Reactive Oxygen Species
chemical_list: D000975:Antioxidants; D017382:Reactive Oxygen Species; D010100:Oxygen