title: Management of pulmonary hypertension in neonates with congenital diaphragmatic hernia.
abstract: Pulmonary hypertension associated with congenital diaphragmatic hernia is still one of the major challenges in neonatal intensive care units. Several relevant pathways in its pathogenesis have been described and studied, but the absence of well-designed randomized controlled trials and the scattered data on the pharmacokinetics and pharmacodynamics of most of the drugs used in these patients hamper progress significantly. This review aims to give an overview of current management strategies in the antenatal and neonatal phase, and provides founded clinical recommendations.
authors.affiliation: Department of Pediatric Surgery, Sophia Children's Hospital, Erasmus MC, Rotterdam, The Netherlands.
authors.forename: S
authors.initials: S
authors.lastname: Vijfhuize
authors.forename: T
authors.initials: T
authors.lastname: Schaible
authors.forename: U
authors.initials: U
authors.lastname: Kraemer
authors.forename: T E
authors.initials: TE
authors.lastname: Cohen-Overbeek
authors.forename: D
authors.initials: D
authors.lastname: Tibboel
authors.forename: I
authors.initials: I
authors.lastname: Reiss
mesh_terms: D000959:Antihypertensive Agents / Q000008:administration & dosage / Q000627:therapeutic use; D015199:Extracorporeal Membrane Oxygenation; D005260:Female; D006548:Hernia, Diaphragmatic / Q000150:complications; D065630:Hernias, Diaphragmatic, Congenital; D006801:Humans; D006976:Hypertension, Pulmonary / Q000175:diagnosis / Q000209:etiology / Q000628:therapy*; D007231:Infant, Newborn; D009569:Nitric Oxide / Q000378:metabolism; D010726:Phosphodiesterase Inhibitors / Q000627:therapeutic use; D011247:Pregnancy; D011295:Prenatal Care / Q000379:methods; D012121:Respiration, Artificial / Q000009:adverse effects / Q000379:methods
chemical_list: D000959:Antihypertensive Agents; D010726:Phosphodiesterase Inhibitors; D009569:Nitric Oxide