title: Label-free in situ detection of individual macromolecular assemblies by surface enhanced Raman scattering.
abstract: We demonstrate label-free detection of lipid vesicles and polystyrene beads freely diffusing in aqueous solution using surface enhanced Raman scattering (SERS). The signals observed enable real-time identification and monitoring of individual particles interacting with the SERS substrate. SERS is demonstrated as a label-free method capable of monitoring transient species in solution on the millisecond time scale.
authors.affiliation: University of Notre Dame, Department of Chemistry and Biochemistry, 251 Nieuwland Science Hall, Notre Dame, IN 46556, USA.
authors.forename: Steven M
authors.initials: SM
authors.lastname: Asiala
authors.forename: Zachary D
authors.initials: ZD
authors.lastname: Schultz
mesh_terms: D004058:Diffusion; D008081:Liposomes / Q000737:chemistry*; D011137:Polystyrenes / Q000737:chemistry; D012834:Silver / Q000737:chemistry; D013059:Spectrum Analysis, Raman; D014867:Water / Q000737:chemistry
chemical_list: D008081:Liposomes; D011137:Polystyrenes; D014867:Water; D012834:Silver