title: Single-agent duloxetine ingestions.
abstract: Duloxetine is a serotonin and norepinephrine reuptake inhibitor, which is mainly used to treat depression. This retrospective study describes the demographic and clinical effects of duloxetine ingestions reported to the National Poison Data System (NPDS). NPDS data were searched for duloxetine exposures between 2004 and 2010. A total of 11,373 patients were included and exposures were divided into three groups of ages ≤6 years old, 7-12 years and >12 years. Neurological clinical effects occurred in 6.1% of the patients aged ≤6 years, 13.0% of the patients aged 7-12 years and 24.6% of the patients aged >12 years. Cardiovascular effects occurred in 1.4% of the patients aged ≤6 years old, 2.5% of the patients aged 7-12 years and 11.6% of the patients aged >12 years. Gastrointestinal effects occurred in 4.1% of the patients aged ≤6 years old, 16.6% of the patients aged 7-12 years and 13.8% of the patients aged >12 years. Tachycardia, nausea, vomiting, agitation/irritability, dizziness/vertigo and drowsiness were among the most common clinical effects in all three groups. Overall, 61.4% of the patients aged ≤6 years and 77.5% of the patients aged 7-12 years were managed in a non-health care facility, while 55.8% of the patients aged >12 years were referred to or already in a health care facility. We conclude that the majority of ingestions are benign in both pediatrics and adults. Most symptomatic patients have neurologic, gastrointestinal and cardiovascular effects. Most pediatric patients will be able to be managed in a non-health care facility.
authors.affiliation: Rocky Mountain Poison and Drug Center, Denver Health and Hospital Authority, Denver, CO 80201, USA. jeena2010.jj@gmail.com
authors.forename: J
authors.initials: J
authors.lastname: Jacob
authors.forename: D
authors.initials: D
authors.lastname: Albert
authors.forename: K
authors.initials: K
authors.lastname: Heard
mesh_terms: D000328:Adult; D000928:Antidepressive Agents / Q000506:poisoning*; D002648:Child; D004244:Dizziness / Q000139:chemically induced; D000068736:Duloxetine Hydrochloride; D004435:Eating; D005260:Female; D006801:Humans; D053609:Lethargy / Q000139:chemically induced; D008297:Male; D008875:Middle Aged; D009325:Nausea / Q000139:chemically induced; D011039:Poison Control Centers / Q000706:statistics & numerical data; D012894:Sleep Stages; D013610:Tachycardia / Q000139:chemically induced; D013876:Thiophenes / Q000506:poisoning*; D014839:Vomiting / Q000139:chemically induced; D055815:Young Adult
chemical_list: D000928:Antidepressive Agents; D013876:Thiophenes; D000068736:Duloxetine Hydrochloride