title: Serum selenium, zinc, and copper in early diagnosed patients with pemphigus vulgaris.
abstract: BACKGROUND
  Pemphigus vulgaris is a life threatening, blistering skin disease. It is an autoimmune abnormality. Due to involvement of oral cavity and pharynx, patients are at risk of nutrients deficiency. The aim of this study was to evaluate the status of selenium, copper, and zinc in these patients.
  
  
  METHODS
  In a case-control study, 43 newly diagnosed pemphigus vulgaris patients were compared with 58 healthy people from 2009 to 2010. The severity of the disease was estimated according to Harman's scores. Serum selenium was measured with atomic absorption but serum zinc and copper concentrations were determined spectrophotometrically. Data were compared with independent t test. Correlations were evaluated by Pearson correlation test.
  
  
  RESULTS
  Both groups were the same based on sex, age, and weight and body mass index. The mean duration of disease was 5.6 month. The oral and skin severities were 1.79 and 2.3 respectively, based on Harman's scores. Serum selenium of pemphigus patients was significantly less than that of healthy people (P<0.001). Serum copper was negatively correlated with duration of disease in males (P=0.02, r=-0.5).
  
  
  CONCLUSIONS
  Pemphigus vulgaris negatively affects on serum selenium, copper and zinc. It seems that serum selenium, copper and zinc decrease as the disease lasts longer.
authors.affiliation: Dept. of Nutrition and Biochemistry, Faculty of Public Health, Tehran University of Medical Sciences, Tehran, Iran.
authors.forename: Mh
authors.initials: M
authors.lastname: Javanbakht
authors.forename: M
authors.initials: M
authors.lastname: Daneshpazhooh
authors.forename: C
authors.initials: C
authors.lastname: Chams-Davatchi
authors.forename: Mr
authors.initials: M
authors.lastname: Eshraghian
authors.forename: M
authors.initials: M
authors.lastname: Zarei
authors.forename: M
authors.initials: M
authors.lastname: Chamari
authors.forename: Djalali
authors.initials: D
authors.lastname: M
keywords: Copper; Pemphigus vulgaris; Selenium; Zinc