title: A concise synthesis of 3-aroylflavones via Lewis base 9-azajulolidine-catalyzed tandem acyl transfer-cyclization.
abstract: Lewis base-catalyzed tandem acyl transfer-cyclization of acylated o-alkynoylphenols leading to 3-aroylflavones was developed. 9-Azajulolidine smoothly promoted the reaction of the aroyl derivatives at ambient temperature, and the structure-diversed synthesis of 3-aroylflavones with distinct substituents was achieved in moderate to excellent yields.
authors.affiliation: Graduate School of Pharmaceutical Sciences, Tohoku University, 6-3 Aza-Aoba, Aramaki, Aoba-ku Sendai 980-8578, Japan.
authors.forename: Masahito
authors.initials: M
authors.lastname: Yoshida
authors.forename: Koya
authors.initials: K
authors.lastname: Saito
authors.forename: Yuta
authors.initials: Y
authors.lastname: Fujino
authors.forename: Takayuki
authors.initials: T
authors.lastname: Doi
mesh_terms: D000215:Acylation; D002384:Catalysis; D003500:Cyclization; D047309:Flavones / Q000138:chemical synthesis* / Q000737:chemistry; D058115:Lewis Bases / Q000737:chemistry*; D011807:Quinolizines / Q000737:chemistry*
chemical_list: D047309:Flavones; D058115:Lewis Bases; D011807:Quinolizines