title: Effect of irbesartan on streptozotocin induced diabetic nephropathy: An interventionary study.
abstract: Effect of irbesartan, an angiotensin II receptor antagonist, was studied in streptozotocin (STZ) induced diabetic nephropathy. Polyuria, proteinuria, blood urea, creatinine clearance, and urinary electrolytes were determined to assess kidney damage. There was a significant increase in urine volume, urinary protein and blood urea in STZ induced diabetic rats. On the other hand, irbesartan treatment resulted in a significant reduction in urinary protein and blood urea in these rats. Irbesartan treatment also improved creatinine clearance and exhibited a natriuretic effect in these animals. Results suggest that irbesartan treatment ameliorate STZ induced diabetic nephropathic changes, in rats.
authors.affiliation: Department of Biochemistry, Pt. B.D Sharma PGIMS, Rohtak, Haryana India.
authors.forename: Richa
authors.initials: R
authors.lastname: Vaishya
authors.forename: Janardhan
authors.initials: J
authors.lastname: Singh
authors.forename: Harbans
authors.initials: H
authors.lastname: Lal
keywords: Diabetic nephropathy; Irbesartan; Streptozotocin