title: A conserved HLA-A*02:28 associated HLA haplotype, A*02:28-B*15:11-DRB1*09:01, restricted to Taiwanese.
abstract: HLA-A*02:28, found in a Korean and a Japanese, was reported independently to the IMGT/HLA database in 2003 and 2005, respectively. We report here eight Taiwanese unrelated bone marrow hematopoietic stem cell donors carrying A*02:28 detected during our routine HLA typing exercise. The probable HLA-A, -B and -DRB1 haplotype in association with A*02:28 may be deduced from the eight marrow stem cell donor as A*02:28-B*15:11-DRB1*09:01. Our result suggests A*02:28-B*15:11-DRB1*09:01 is a conserved HLA haplotype restricted to Taiwanese.
authors.affiliation: Laboratory of Immunogenetics and Cord Blood Bank, Buddhist Tzu Chi Stem Cells Centre and Marrow Donor Registry, Buddhist Tzu Chi General Hospital, Buddhist Compassion Relief Tzu Chi Foundation, Hualien, Taiwan. edward@tzuchi.com.tw
authors.forename: K L
authors.initials: KL
authors.lastname: Yang
authors.forename: S K
authors.initials: SK
authors.lastname: Lee
authors.forename: P Y
authors.initials: PY
authors.lastname: Lin
mesh_terms: D000483:Alleles; D044466:Asian People / Q000235:genetics*; D001483:Base Sequence; D001854:Bone Marrow Cells / Q000166:cytology; D017124:Conserved Sequence; D005787:Gene Frequency / Q000235:genetics; D015789:HLA-A2 Antigen / Q000235:genetics* / Q000276:immunology; D059811:HLA-DRB1 Chains / Q000235:genetics*; D006239:Haplotypes / Q000235:genetics / Q000276:immunology; D018380:Hematopoietic Stem Cell Transplantation; D006412:Hematopoietic Stem Cells / Q000166:cytology*; D006650:Histocompatibility Testing; D006801:Humans; D008969:Molecular Sequence Data; D017422:Sequence Analysis, DNA; D013624:Taiwan
chemical_list: C524866:HLA-A*02 antigen; D015789:HLA-A2 Antigen; D059811:HLA-DRB1 Chains