title: [Regenerative medicine: orthopaedical applications and medico legal questions].
abstract: Over the last decades, the increase in the global population's mean age has implied a corresponding increase in degenerative disease affecting various anatomical areas and tissues, including bones and cartilages, thus provoking a rising number of disabilities and a wider usage of drugs, mostly anti-inflammatory and cortisone. New developments in technologic and biomedical fields gave birth to new subjects, such as tissue engineering, cell therapy, gene therapy that, by and large, create a knowledge network falling under the concept of Regenerative Medicine. This science is essentially based on the usage of stem cells that can replicate and renovate themselves originating, if adequately stimulated, a number of cell types. Inter alia, in orthopaedic field a particular type of adult stem cells is used, the mesenchymal stem cells (MSCs). If combined with synthetic material produced in laboratories, the usage of these cells has provided inspiration for new study interests; today, it can be applied in various degenerative and post-traumatic pathologies, with great therapeutic benefits for the patient. Actually, many studies write about an improvement in patients' life quality. In this sense appear significant reflections on legal medicine, both in accidents and insurance, of this innovative therapeutic alternative and is hopefully an equally valid process of improvement of regulatory and case law.
authors.affiliation: Dipartimento di Scienze Anatomiche, Unità Operativa di Medicina Sociale, Università Sapienza, Roma, Italia. serafino.ricci@uniroma1.it
authors.forename: S
authors.initials: S
authors.lastname: Ricci
authors.forename: O
authors.initials: O
authors.lastname: Ricci
authors.forename: C E
authors.initials: CE
authors.lastname: Tucci
authors.forename: F
authors.initials: F
authors.lastname: Massoni
authors.forename: M V
authors.initials: MV
authors.lastname: Sarra
authors.forename: S
authors.initials: S
authors.lastname: Ricci
mesh_terms: D006801:Humans; D009985:Orthopedics / Q000331:legislation & jurisprudence* / Q000379:methods*; D044968:Regenerative Medicine / Q000331:legislation & jurisprudence*