title: Adipocyte biology in polycystic ovary syndrome.
abstract: Polycystic Ovary Syndrome (PCOS) is a common endocrinopathy that is associated with an adverse metabolic profile including insulin resistance. There is a clear association between obesity, the development of PCOS and the severity of its phenotypic, biochemical and metabolic features. Evidence to support this link includes data from epidemiological, pathophysiological and genetic studies. Given the importance of obesity in the development and manifestation of PCOS, ongoing research into the many facets of adipocyte biology in women with the condition is important and should continue to be a priority. In this review article, we discuss the existing literature on fat distribution, adipokines, adipocyte hypertrophy and adipocyte steroid metabolism in women with PCOS.
authors.affiliation: Warwickshire Institute for the Study of Diabetes, Endocrinology and Metabolism, University of Warwick, Coventry CV2 2DX, United Kingdom. T.Barber@warwick.ac.uk
authors.forename: T M
authors.initials: TM
authors.lastname: Barber
authors.forename: S
authors.initials: S
authors.lastname: Franks
mesh_terms: D017667:Adipocytes / Q000502:physiology*; D054392:Adipokines / Q000378:metabolism; D050154:Adiposity; D053898:Biosynthetic Pathways; D050218:Body Fat Distribution; D005260:Female; D012739:Gonadal Steroid Hormones / Q000096:biosynthesis; D006801:Humans; D050356:Lipid Metabolism; D011085:Polycystic Ovary Syndrome / Q000378:metabolism / Q000473:pathology*
chemical_list: D054392:Adipokines; D012739:Gonadal Steroid Hormones