title: Novel dibenzo[b,e]oxepinones from the freshwater-derived fungus Chaetomium sp. YMF 1.02105.
abstract: Six new dibenzo[b,e]oxepinone metabolites, chaetones A-F (1-6), as well as three known compounds, 1-hydroxy-6-methyl-8-hydroxymethylxanthone (7), citreorosein (8), and emodin (9), were obtained from a freshwater-derived fungal strain Chaetomium sp. YMF 1.02105. Their structures were established on the basis of extensive spectroscopic data analysis and comparison with spectroscopic data reported. Compounds 1-6 are further additions to the small group of dibenzo[b,e]oxepinones represented by arugosins A-H. Compounds 1-7 were tested for their cytotoxic activities against A549, Raji, HepG2, MCF-7, and HL-60 cell lines. The results showed that compound 3 had significant cytotoxicity with IC50 values of 1.2, 1.8, 1.9, 2.3, and 1.6 µg/mL, respectively, against the five cancer cell lines. All compounds showed modest antimicrobial activity against Staphylococcus aureus (ATCC 6538) in standard disk assays.
authors.affiliation: School of Life Science, Southwest University, Beibei, Chongqing, People's Republic of China.
authors.forename: Kai-Ze
authors.initials: KZ
authors.lastname: Shen
authors.forename: Suo
authors.initials: S
authors.lastname: Gao
authors.forename: Yan-Xiu
authors.initials: YX
authors.lastname: Gao
authors.forename: An-Ran
authors.initials: AR
authors.lastname: Wang
authors.forename: Yao-Bo
authors.initials: YB
authors.lastname: Xu
authors.forename: Rong
authors.initials: R
authors.lastname: Sun
authors.forename: Pei-Gen
authors.initials: PG
authors.lastname: Hu
authors.forename: Guo-Fu
authors.initials: GF
authors.lastname: Yang
authors.forename: Ai-Ji
authors.initials: AJ
authors.lastname: Li
authors.forename: Dan
authors.initials: D
authors.lastname: Zhong
authors.forename: Hai-Yang
authors.initials: HY
authors.lastname: Liu
authors.forename: Jin-Yan
authors.initials: JY
authors.lastname: Dong
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D045744:Cell Line, Tumor / Q000187:drug effects; D002597:Chaetomium / Q000737:chemistry*; D003603:Cytotoxins / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D003990:Dibenzoxepins / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D005618:Fresh Water / Q000382:microbiology; D006801:Humans; D020128:Inhibitory Concentration 50; D015394:Molecular Structure; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D013211:Staphylococcus aureus / Q000187:drug effects
chemical_list: D000900:Anti-Bacterial Agents; D003603:Cytotoxins; D003990:Dibenzoxepins; D010936:Plant Extracts; C580916:chaetone C