title: Effect of chitooligosaccharides on mice hematopoietic stem/progenitor cells.
abstract: Chitooligosaccharides (COSs) is a kind of polysaccharide scaffolds used to enhance cartilage repair during treatments involving bone marrow stimulation, angiogenesis and osteogenesis increase in vivo. Capabilities of COSs in promoting the proliferation and differentiation of hematopoietic stem cells/hematopoietic progenitor cells were mainly explored in the paper. The results showed that a high concentration of COSs significantly proliferate the mice marrow cells and induced CD34+ cells into megakaryocyte progenitor cells. However, COSs could not enhance the proliferation of CD19+ and CD4+ and promote CD34+ cells to differentiate into lymphoid progenitor cells. It suggested that COSs can promote hematopoietic stem/progenitor cells hyperplasia, and the mechanism may be that COSs promote stromal cell secretion of hematopoietic growth factors.
authors.affiliation: Institute of Food Engineering, College of Life & Environment Science, Shanghai Normal University, 100 Guilin Rd, Shanghai 200234, PR China.
authors.forename: Xinlin
authors.initials: X
authors.lastname: Wei
authors.forename: Wei
authors.initials: W
authors.lastname: Chen
authors.forename: Fang
authors.initials: F
authors.lastname: Mao
authors.forename: Yuanfeng
authors.initials: Y
authors.lastname: Wang
mesh_terms: D000818:Animals; D018941:Antigens, CD19 / Q000378:metabolism; D018952:Antigens, CD34 / Q000378:metabolism; D001854:Bone Marrow Cells / Q000166:cytology / Q000187:drug effects / Q000378:metabolism; D015496:CD4-Positive T-Lymphocytes / Q000166:cytology / Q000187:drug effects / Q000378:metabolism; D002851:Chromatography, High Pressure Liquid; D006412:Hematopoietic Stem Cells / Q000166:cytology* / Q000187:drug effects* / Q000378:metabolism; D018189:Immunomagnetic Separation; D051379:Mice; D009844:Oligosaccharides / Q000494:pharmacology*; D040201:Platelet Membrane Glycoprotein IIb / Q000378:metabolism; D017154:Stromal Cells / Q000166:cytology / Q000187:drug effects / Q000378:metabolism
chemical_list: D018941:Antigens, CD19; D018952:Antigens, CD34; D009844:Oligosaccharides; D040201:Platelet Membrane Glycoprotein IIb