title: Baicalein inhibits DMBA/TPA-induced skin tumorigenesis in mice by modulating proliferation, apoptosis, and inflammation.
abstract: Baicalein, one of the four major flavanoids extracted from the root of Scutellaria baicalensis, has been shown to exert chemopreventive effect against several cancers, including skin cancer. However, the precise mechanisms remain to be elucidated. In the present study, we investigated the chemopreventive activity of baicalein against 7,12-dimethylbenz[a]anthracene (DMBA)/12-O-tetradecanoylphorbol-13-acetate (TPA)-mediated skin tumorigenesis in C57BL/6 mice. We found that topical treatment with baicalein resulted in a significant inhibitory effect on DMBA/TPA-mediated tumor promotion. Furthermore, we observed that baicalein suppressed cell proliferation and promoted apoptosis in DMBA/TPA-mediated group. Additionally, pretreatment with baicalein inhibited the production of inflammatory cells in DMBA/TPA-induced skin/tumors. Further experiments showed that baicalein reduced TPA-induced skin hyperplasia as well as infiltration of polymorphonuclear leukocytes in the dermis. In conclusion, our data suggest that baicalein inhibits DMBA/TPA-induced skin tumorigenesis by suppressing proliferation and inflammation and promoting apoptosis.
authors.affiliation: Department of Dermatology, The First Affiliated Hospital of China Medical University, 155 North Nanjing Street, Shenyang, 110001, People's Republic of China.
authors.forename: Guo-Zhang
authors.initials: GZ
authors.lastname: Ma
authors.forename: Chun-Hui
authors.initials: CH
authors.lastname: Liu
authors.forename: Bin
authors.initials: B
authors.lastname: Wei
authors.forename: Jie
authors.initials: J
authors.lastname: Qiao
authors.forename: Tao
authors.initials: T
authors.lastname: Lu
authors.forename: Hua-Chen
authors.initials: HC
authors.lastname: Wei
authors.forename: Hong-Duo
authors.initials: HD
authors.lastname: Chen
authors.forename: Chun-Di
authors.initials: CD
authors.lastname: He
mesh_terms: D015127:9,10-Dimethyl-1,2-benzanthracene; D000818:Animals; D016588:Anticarcinogenic Agents / Q000494:pharmacology*; D017209:Apoptosis / Q000187:drug effects; D049109:Cell Proliferation / Q000187:drug effects; D002471:Cell Transformation, Neoplastic / Q000139:chemically induced / Q000187:drug effects*; D005260:Female; D044950:Flavanones / Q000494:pharmacology*; D006965:Hyperplasia / Q000139:chemically induced / Q000188:drug therapy; D007249:Inflammation / Q000188:drug therapy; D051379:Mice; D008810:Mice, Inbred C57BL; D010936:Plant Extracts / Q000494:pharmacology*; D031364:Scutellaria baicalensis; D012878:Skin Neoplasms / Q000139:chemically induced / Q000188:drug therapy / Q000517:prevention & control*; D013755:Tetradecanoylphorbol Acetate
chemical_list: D016588:Anticarcinogenic Agents; D044950:Flavanones; D010936:Plant Extracts; C499814:Scutellaria baicalensis extract; C006680:baicalein; D015127:9,10-Dimethyl-1,2-benzanthracene; D013755:Tetradecanoylphorbol Acetate