title: A correlative model to predict in vivo AUC for nanosystem drug delivery with release rate-limited absorption.
abstract: OBJECTIVE
  Drug release from nanosystems at the sites of either absorption or effect biophase is a major determinant of its biological action. Thus, in vitro drug release is of paramount importance in gaining insight for the systems performance in vivo.
  
  
  METHODS
  A novel in vitro in vivo correlation, IVIVC, model denoted as double reciprocal area method was presented and applied to 19 drugs from 55 nano formulations with total 336 data, gathered from literature.
  
  
  RESULTS
  The proposed model correlated the in vitro with in vivo parameters with overall error of 12.4 ± 3.9%. Also the trained version of the model predicted the test formulations with overall error of 15.8 ± 3.7% indicating the suitability of the approach. A theoretical justification was provided for the model considering the unified classical release laws.
  
  
  CONCLUSIONS
  The model does not necessitate bolus intravenous drug data and seems to be suitable for IVIVC of drugs with release rate-limited absorption.
authors.affiliation: Faculty of Pharmacy, Kermanshah University of Medical Sciences, Kermanshah, Iran.
authors.forename: Mohammad
authors.initials: M
authors.lastname: Barzegar-Jalali
authors.forename: Kaivan
authors.initials: K
authors.lastname: Mohammadi
authors.forename: Ghobad
authors.initials: G
authors.lastname: Mohammadi
authors.forename: Hadi
authors.initials: H
authors.lastname: Valizadeh
authors.forename: Azim
authors.initials: A
authors.lastname: Barzegar-Jalali
authors.forename: Khosro
authors.initials: K
authors.lastname: Adibkia
authors.forename: Ali
authors.initials: A
authors.lastname: Nokhodchi
mesh_terms: D000042:Absorption; D019540:Area Under Curve; D002626:Chemistry, Pharmaceutical / Q000379:methods; D016503:Drug Delivery Systems / Q000379:methods*; D008954:Models, Biological; D053758:Nanoparticles / Q000008:administration & dosage*; D036103:Nanotechnology / Q000379:methods*; D010599:Pharmacokinetics