title: Sustained high level of serum VEGF at convalescent stage contributes to the renal recovery after HTNV infection in patients with hemorrhagic fever with renal syndrome.
abstract: To investigate the role of vascular endothelial growth factor (VEGF) in the increased permeability of vascular endothelial cells after Hantaan virus (HTNV) infection in humans, the concentration of VEGF in serum from HTNV infected patients was quantified with sandwich ELISA. Generally, the level of serum VEGF in patients was elevated to 607.0 (542.2-671.9) pg/mL, which was dramatically higher compared with healthy controls (P < 0.001). There was a rapid increase of the serum VEGF level in all patients from the fever onset to oliguric stage, at which the serum creatinine reached the peak level of the disease, indicating that VEGF may be involved in the pathogenesis of renal hyper-permeability. Moreover, the serum VEGF level at convalescent stage was positively correlated with the degree of the disease severity. The sustained high level of serum VEGF at convalescence was observed in critical HFRS patients, suggesting that VEGF would probably contribute to the renal recovery after the virus clearance. Taken together, our results suggested that the VEGF would be involved in the pathogenesis of renal dysfunction at the oliguric stage after HTNV infection, but may function as a recovery factor during the convalescence to help the body self-repair of the renal injury.
authors.affiliation: Department of Immunology, The Fourth Military Medical University, 169 Changle West Road, Xi'an 710032, China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Ma
authors.forename: Bei
authors.initials: B
authors.lastname: Liu
authors.forename: Bin
authors.initials: B
authors.lastname: Yuan
authors.forename: Jiuping
authors.initials: J
authors.lastname: Wang
authors.forename: Haitao
authors.initials: H
authors.lastname: Yu
authors.forename: Yun
authors.initials: Y
authors.lastname: Zhang
authors.forename: Zhuwei
authors.initials: Z
authors.lastname: Xu
authors.forename: Yusi
authors.initials: Y
authors.lastname: Zhang
authors.forename: Jing
authors.initials: J
authors.lastname: Yi
authors.forename: Chunmei
authors.initials: C
authors.lastname: Zhang
authors.forename: Xingchun
authors.initials: X
authors.lastname: Zhou
authors.forename: Angang
authors.initials: A
authors.lastname: Yang
authors.forename: Ran
authors.initials: R
authors.lastname: Zhuang
authors.forename: Boquan
authors.initials: B
authors.lastname: Jin
mesh_terms: D000328:Adult; D002199:Capillary Permeability / Q000502:physiology; D016022:Case-Control Studies; D003289:Convalescence; D042783:Endothelial Cells / Q000502:physiology / Q000821:virology; D005260:Female; D005334:Fever / Q000097:blood / Q000821:virology; D018063:Hantaan virus; D018778:Hantavirus Infections / Q000097:blood* / Q000503:physiopathology / Q000821:virology; D006480:Hemorrhagic Fever with Renal Syndrome / Q000097:blood* / Q000503:physiopathology / Q000821:virology; D006801:Humans; D007668:Kidney / Q000503:physiopathology / Q000821:virology; D008297:Male; D008875:Middle Aged; D044967:Serum; D042461:Vascular Endothelial Growth Factor A / Q000097:blood*
chemical_list: D042461:Vascular Endothelial Growth Factor A