title: Neuropathic pain-attenuating potential of aliskiren in chronic constriction injury model in rats.
abstract: The present study was designed to investigate the potential of aliskiren, a direct renin inhibitor, in chronic constriction injury (CCI)-induced neuropathic pain in rats. Neuropathic pain was induced by placing four loose ligatures around the sciatic nerve. Acetone drop, von Frey hair, pin-prick and hot plate tests were performed to assess cold allodynia, mechanical allodynia, mechanical and heat hyperalgesia, respectively. The levels of Tumor necrosis factor-alpha (TNF-α) were measured in the sciatic nerve as an inflammatory marker. CCI was associated with the development of cold allodynia, mechanical allodynia, mechanical and heat hyperalgesia along with a rise in the levels of Tumor necrosis factor-alpha (TNF-α). Administration of aliskiren (25 or 50 mg/kg intraperitoneal (i.p.)) for 14 days in CCI-subjected rats significantly attenuated CCI-induced pain-related behavior and rise in TNF-α level. It may be concluded that aliskiren-mediated anti-inflammatory actions may be responsible for its beneficial effects in neuropathic pain in rats.
authors.affiliation: Department of Pharmaceutical Sciences and Drug Research, Punjabi University, India.
authors.forename: Ankesh
authors.initials: A
authors.lastname: Kukkar
authors.forename: Nirmal
authors.initials: N
authors.lastname: Singh
authors.forename: Amteshwar S
authors.initials: AS
authors.lastname: Jaggi
mesh_terms: D000577:Amides / Q000494:pharmacology / Q000627:therapeutic use*; D000818:Animals; D003250:Constriction; D004195:Disease Models, Animal; D005260:Female; D005650:Fumarates / Q000494:pharmacology / Q000627:therapeutic use*; D006930:Hyperalgesia / Q000150:complications / Q000188:drug therapy; D008297:Male; D009437:Neuralgia / Q000150:complications / Q000188:drug therapy*; D051381:Rats; D017207:Rats, Sprague-Dawley; D012584:Sciatic Nerve / Q000187:drug effects / Q000293:injuries* / Q000473:pathology; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism
chemical_list: D000577:Amides; D005650:Fumarates; D014409:Tumor Necrosis Factor-alpha; C446481:aliskiren
keywords: Chronic constriction injury; aliskiren; inflammation; neuropathic pain; sciatic nerve ligation