title: Effect of vitamin E on platelet enzymatic anti-oxidants in the patients of myocardial infarction.
abstract: Effect of administration of 600 mg. vitamin E each day, for six days, was observed on activity of some of the anti-oxidant enzymes and levels of malondialdehyde (as an index of free radical mediated damage) in the platelets of patients reperfused after myocardial infarction. It has been found that vitamin E administration significantly lowers the level of malondialdehyde in the patients. Vitamin E administration increases the activities of anti oxidant enzymes (viz. superoxide dismutase, glutathione reductase and catalase) tested both in the patients and healthy controls. Vitamin E administration causes general stimulation of anti-oxidant enzyme activities both in healthy persons and the patients, however, lowering of lipid per-oxidation upon administration of vitamin E is specific for patients. These findings exhibit beneficial role of vitamin E administration in the management of the patients reperfused after myocardial infarction.
authors.affiliation: Department of Biochemistry, University of Lucknow, 226 007 Lucknow.
authors.forename: Vivek K
authors.initials: VK
authors.lastname: Dwivedi
authors.forename: Mahesh
authors.initials: M
authors.lastname: Chandra
authors.forename: P C
authors.initials: PC
authors.lastname: Misra
authors.forename: M K
authors.initials: MK
authors.lastname: Misra
keywords: Vitamin E; anti-oxidant enzymes; lipid per oxidation; myocardial infarction; platelets