title: [Magnesium in the treatment and prevention of cerebrovascular disease].
abstract: To date, the amount of evidences for the role of magnesium in determining the energy potential of the cells increases, which is critical in the pathogenesis of stroke, as well as in the survival and recovery of  brain cells. Energy donor in cellular processes is adenosine triphosphate (ATP) as a complex of Mg2+- ATP [1]. In acute and chronic cerebral ischemia deficit Mg2+  is the basis of hypoxia cells, which leads to their subsequent death. [2]. Severe deficiency of selenium, when there is an issue of life and death of the patient, requires a massive correction of magnesium homeostasis. It is an integral component of intensive care in neurology, cardiology, obstetrics. However, in daily practice neurologist frequently has patients with chronic cerebrovascular disease, accompanied by magnesium deficiency. This proves necessitate of the use of magnesium containing drugs with neuroprotective and neurotrophic properties in the treatment and prevention of cerebrovascular disease.
authors.forename: E S
authors.initials: ES
authors.lastname: Akarachkova
authors.forename: S V
authors.initials: SV
authors.lastname: Vershinina
authors.forename: O V
authors.initials: OV
authors.lastname: Kotova
mesh_terms: D000255:Adenosine Triphosphate / Q000378:metabolism; D001921:Brain / Q000187:drug effects / Q000378:metabolism; D016923:Cell Death / Q000187:drug effects; D015687:Cell Hypoxia / Q000187:drug effects; D002462:Cell Membrane / Q000187:drug effects / Q000378:metabolism; D002561:Cerebrovascular Disorders / Q000150:complications / Q000175:diagnosis / Q000188:drug therapy / Q000378:metabolism; D004734:Energy Metabolism / Q000187:drug effects*; D006801:Humans; D008274:Magnesium / Q000378:metabolism / Q000494:pharmacology / Q000627:therapeutic use; D008275:Magnesium Deficiency / Q000150:complications / Q000188:drug therapy / Q000378:metabolism; D018696:Neuroprotective Agents / Q000494:pharmacology / Q000627:therapeutic use; D009753:Nutritive Value; D014131:Trace Elements; D016896:Treatment Outcome
chemical_list: D018696:Neuroprotective Agents; D014131:Trace Elements; D000255:Adenosine Triphosphate; D008274:Magnesium