title: 13CFLUX2--high-performance software suite for (13)C-metabolic flux analysis.
abstract: CONCLUSIONS
  (13)C-based metabolic flux analysis ((13)C-MFA) is the state-of-the-art method to quantitatively determine in vivo metabolic reaction rates in microorganisms. 13CFLUX2 contains all tools for composing flexible computational (13)C-MFA workflows to design and evaluate carbon labeling experiments. A specially developed XML language, FluxML, highly efficient data structures and simulation algorithms achieve a maximum of performance and effectiveness. Support of multicore CPUs, as well as compute clusters, enables scalable investigations. 13CFLUX2 outperforms existing tools in terms of universality, flexibility and built-in features. Therewith, 13CFLUX2 paves the way for next-generation high-resolution (13)C-MFA applications on the large scale.
  
  
  METHODS
  13CFLUX2 is implemented in C++ (ISO/IEC 14882 standard) with Java and Python add-ons to run under Linux/Unix. A demo version and binaries are available at www.13cflux.net.
authors.affiliation: Institute of Bio- and Geosciences, IBG-1: Biotechnology, Germany.
authors.forename: Michael
authors.initials: M
authors.lastname: Weitzel
authors.forename: Katharina
authors.initials: K
authors.lastname: Nöh
authors.forename: Tolga
authors.initials: T
authors.lastname: Dalman
authors.forename: Sebastian
authors.initials: S
authors.lastname: Niedenführ
authors.forename: Birgit
authors.initials: B
authors.lastname: Stute
authors.forename: Wolfgang
authors.initials: W
authors.lastname: Wiechert
mesh_terms: D000465:Algorithms; D002247:Carbon Isotopes; D008660:Metabolism; D012984:Software
chemical_list: D002247:Carbon Isotopes