title: Prevalence, treatment, and outcomes of coexistent ocular surface squamous neoplasia and pterygium.
abstract: OBJECTIVE
  The purpose of this study was to determine the prevalence of ocular surface squamous neoplasia (OSSN) coexisting with pterygia in South Florida and to study the treatment and related outcomes.
  
  
  METHODS
  Noninterventional retrospective study.
  
  
  METHODS
  A total of 2005 patients with surgically excised pterygia at the Bascom Palmer Eye Institute from 2000 to 2010.
  
  
  METHODS
  Pathology reports of patients with pterygia were reviewed for evidence of OSSN. Patients were divided into the following groups: pterygium and no OSSN (group 1), clinically suspected OSSN with pterygium (group 2), and unexpected OSSN with pterygium found on histopathology (group 3). Clinical charts of patients in groups 2 and 3 were reviewed.
  
  
  METHODS
  Period prevalence, treatment, and outcome.
  
  
  RESULTS
  In surgically excised pterygia, the prevalence of coexistent OSSN was 1.7% (n = 34), of which 41% (n = 14) were clinically suspected preoperatively (group 2) and 59% (n = 20) were unexpectedly found on histopathology (group 3). Clinically suspected OSSN with pterygia was generally treated with wide surgical margins and cryotherapy, whereas unexpected OSSN with pterygia was treated with simple excision, followed by adjuvant interferon treatment in 30% (n = 6). After a mean follow-up of 2 years, there were no recurrences in the suspected OSSN group and 2 recurrences in the unexpected OSSN group. The recurrence rate in the latter group was 11% at 1 year and 24% at 2 years.
  
  
  CONCLUSIONS
  Ocular surface squamous neoplasia is uncommonly found to coexist with pterygium. The prognosis in suspected OSSN cases is excellent, with no recurrences noted despite positive margins in 50% of cases. The recurrence rates of unexpected OSSN mirrors that of OSSN not associated with pterygium, and thus vigilance for recurrence is important.
authors.affiliation: Bascom Palmer Eye Institute, University of Miami, Miami, Florida.
authors.forename: Patrick
authors.initials: P
authors.lastname: Oellers
authors.affiliation: Bascom Palmer Eye Institute, University of Miami, Miami, Florida. Electronic address: ckarp@med.miami.edu.
authors.forename: Carol L
authors.initials: CL
authors.lastname: Karp
authors.affiliation: Bascom Palmer Eye Institute, University of Miami, Miami, Florida.
authors.forename: Anoop
authors.initials: A
authors.lastname: Sheth
authors.affiliation: Bascom Palmer Eye Institute, University of Miami, Miami, Florida; Florida Lions Ocular Pathology Laboratory, Miami, Florida.
authors.forename: Andrew A
authors.initials: AA
authors.lastname: Kao
authors.affiliation: Bascom Palmer Eye Institute, University of Miami, Miami, Florida.
authors.forename: Amany
authors.initials: A
authors.lastname: Abdelaziz
authors.affiliation: Bascom Palmer Eye Institute, University of Miami, Miami, Florida; Florida Lions Ocular Pathology Laboratory, Miami, Florida.
authors.forename: Jared L
authors.initials: JL
authors.lastname: Matthews
authors.affiliation: Bascom Palmer Eye Institute, University of Miami, Miami, Florida; Florida Lions Ocular Pathology Laboratory, Miami, Florida.
authors.forename: Sander R
authors.initials: SR
authors.lastname: Dubovy
authors.affiliation: Bascom Palmer Eye Institute, University of Miami, Miami, Florida; Miami Veterans Affairs Medical Center, Miami, Florida.
authors.forename: Anat
authors.initials: A
authors.lastname: Galor
mesh_terms: D000328:Adult; D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000453:epidemiology / Q000473:pathology / Q000601:surgery; D003131:Combined Modality Therapy; D015897:Comorbidity; D003230:Conjunctival Neoplasms / Q000453:epidemiology / Q000473:pathology / Q000601:surgery; D003316:Corneal Diseases / Q000453:epidemiology / Q000473:pathology / Q000601:surgery; D017679:Cryotherapy; D005134:Eye Neoplasms / Q000453:epidemiology / Q000473:pathology / Q000601:surgery; D005260:Female; D005431:Florida / Q000453:epidemiology; D006801:Humans; D000077190:Interferon alpha-2; D016898:Interferon-alpha / Q000008:administration & dosage; D008297:Male; D008875:Middle Aged; D013508:Ophthalmologic Surgical Procedures; D015995:Prevalence; D011625:Pterygium / Q000453:epidemiology / Q000473:pathology / Q000601:surgery; D011994:Recombinant Proteins / Q000008:administration & dosage; D012189:Retrospective Studies; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D000077190:Interferon alpha-2; D016898:Interferon-alpha; D011994:Recombinant Proteins