title: Impact of age and sex on carotid and peripheral arterial wall thickness in humans.
abstract: BACKGROUND
  Although previous studies have reported age-related wall thickening in carotid arteries, it is not clear whether this is a systemic phenomenon which is also apparent in peripheral conduit arteries or whether conduit wall thickness (WT) changes occur to a similar degree in men and women.
  
  
  OBJECTIVE
  To determine whether sex modifies the impact of ageing on WT or wall-to-lumen ratio (W:L) in atherosclerosis-prone (i.e. carotid artery, femoral, superficial femoral, popliteal artery) and atherosclerosis-resistant (i.e. brachial artery) conduit arteries.
  
  
  METHODS
  We included 30 young (23 ± 2 year; 15M : 15F) and 31 older (70 ± 5 year; 18M : 13F) healthy subjects. High-resolution ultrasound was used to measure diameter, WT and wall-to-lumen ratio (W/L) in all arteries.
  
  
  RESULTS
  Older subjects had increased WT and W/L in the carotid, femoral, superficial femoral, popliteal and brachial arteries (all P < 0.05). Compared with women, men demonstrated larger diameter and WT (both P < 0.01) across all arteries. Sex did not impact upon age-related changes in WT or W/L (P = 0.39 and 0.43 respectively).
  
  
  CONCLUSIONS
  Our data suggest that age-related wall thickening, evident in the carotid artery, is also apparent in the arteries of the upper and lower limbs. The impact of age on wall thickening did not differ between men and women. These data support the presence of systemic increases in WT and W/L with age in apparently healthy humans, independent of sex.
authors.affiliation: Department of Physiology, Radboud University Nijmegen Medical Centre, the Netherlands.
authors.forename: I
authors.initials: I
authors.lastname: van den Munckhof
authors.forename: R
authors.initials: R
authors.lastname: Scholten
authors.forename: N T
authors.initials: NT
authors.lastname: Cable
authors.forename: M T E
authors.initials: MT
authors.lastname: Hopman
authors.forename: D J
authors.initials: DJ
authors.lastname: Green
authors.forename: D H J
authors.initials: DH
authors.lastname: Thijssen
mesh_terms: D000328:Adult; D017677:Age Distribution; D000368:Aged; D000704:Analysis of Variance; D001158:Arteries / Q000473:pathology*; D050197:Atherosclerosis / Q000473:pathology*; D005260:Female; D006801:Humans; D008297:Male; D012307:Risk Factors; D012737:Sex Factors; D055815:Young Adult