title: Importance of the adrenergic nerve system in the response of gases in the arterial blood following the provoked bronchospasm.
abstract: BACKGROUND
  This work, partial pressure of the respiratory gases in the capillary blood (pH, PaO2, PaCO2) was studied, following the protective action of the beta2-drenergic stimulator-Hexoprenaline and alpha2-adrenergic blocker-Tolazoline in the bronchoconstriction caused by a beta-blocker-Propranolol.
  
  
  METHODS
  in patients with increased bronchial reactibility. pH, oxygen partial pressure (PaO2), dioxide carbon partial pressure (PaCO2) in the arterial blood, with the assistance of the analyzer IL, following some minutes of sample taking were defined in all patients. As a standard to verify the accuracy of the measurement, ampoule solutions of pH, PaO2 and PaCO2 were utilized (Acidobasel, Berlin).
  
  
  CONCLUSIONS
  Following the inhalation of the beta-blocker-Propranolol (20 mg/ml-aerosol), there was an evident decrease (p < 0.05) of pO2 and a non-significant increase (p > 0.1) of pCO2. Beta2-adrenergcic stimulator-Hexoprenaline (2 inh x 0.2 mg), shows an protective effect in the decrease of pO2 (p < 0.05) following the bronchoconstriction being provoked by Propranolol. Alpha2-adrenergic blocker-Tolazoline (20 mg/ml-aerosol), has not shown a protective action in the bronchoconstriction caused with propranolol, therefore significant decrease (p < 0.05) of pO2 and a non-significant increase (p > 0.1) of pCO2 appeared. This shows that stimulation of beta2-adrenergic receptor has protective action in changes of the respiratory gases. Meantime, blocker of the alpha2-adrenergic receptor (Tolazoline) has not shown a protective action in changes of the respiratory gases.
authors.affiliation: Department of Pharmacology, Faculty of Medicine, University of Prishtina. Clinical Centre, Prishtina, Kosova. islamihilmi@hotmail.com
authors.forename: Hilmi
authors.initials: H
authors.lastname: Islami
authors.forename: Arta
authors.initials: A
authors.lastname: Veseli
authors.forename: Emir
authors.initials: E
authors.lastname: Behluli
authors.forename: Naim
authors.initials: N
authors.lastname: Morina
mesh_terms: D000317:Adrenergic alpha-Antagonists / Q000494:pharmacology; D058666:Adrenergic beta-2 Receptor Agonists; D000319:Adrenergic beta-Antagonists / Q000494:pharmacology; D000328:Adult; D001986:Bronchial Spasm / Q000503:physiopathology*; D002245:Carbon Dioxide / Q000097:blood*; D005260:Female; D006594:Hexoprenaline / Q000494:pharmacology; D006801:Humans; D008297:Male; D010100:Oxygen / Q000097:blood*; D010313:Partial Pressure; D011433:Propranolol / Q000494:pharmacology; D029424:Pulmonary Disease, Chronic Obstructive / Q000503:physiopathology; D011659:Pulmonary Gas Exchange; D011941:Receptors, Adrenergic / Q000502:physiology*; D014043:Tolazoline / Q000494:pharmacology
chemical_list: D000317:Adrenergic alpha-Antagonists; D058666:Adrenergic beta-2 Receptor Agonists; D000319:Adrenergic beta-Antagonists; D011941:Receptors, Adrenergic; D002245:Carbon Dioxide; D011433:Propranolol; D014043:Tolazoline; D006594:Hexoprenaline; D010100:Oxygen