title: Study of apolipoproteinc3 Sstl polymorphism in healthy volunteers from Northern India.
abstract: Several studies including a small case-control (hypertriglyceridemic/normotriglyceridemic individuals) study by us revealed close association between rare S2 allele ofAPOC3 Sstl polymorphism and hypertriglyceridemia. With the understanding that Asian Indians are highly vulnerable to the adverse effects of hypertriglyceridemia, we extended the investigation and studied the frequency distribution of this polymorphism in 216 healthy volunteers from Northern plains of India. We found that more than 50% of the study population had one or two S2 allele. This may suggest that a larger fraction of this population is genetically predisposed to hypertriglyceridemia.
authors.affiliation: Department of Biochemistry, All India Institute of Medical Sciences, Ansari Nagar, 110029 New Delhi, India.
authors.forename: S
authors.initials: S
authors.lastname: Chhabra
authors.forename: D P
authors.initials: DP
authors.lastname: Agarwal
authors.forename: S
authors.initials: S
authors.lastname: Vasisht
authors.forename: K
authors.initials: K
authors.lastname: Luthra
authors.forename: R
authors.initials: R
authors.lastname: Narang
authors.forename: S C
authors.initials: SC
authors.lastname: Manchanda
authors.forename: L M
authors.initials: LM
authors.lastname: Srivastava
authors.forename: N
authors.initials: N
authors.lastname: Das
keywords: APOC3; CAD; Hypertriglyceridemia; India; Sstl polymorphism