title: Tetrandrine exerts antidepressant-like effects in animal models: role of brain-derived neurotrophic factor.
abstract: The present study focused on investigating the antidepressant potential of tetrandrine and its possible mechanisms of action. Forced swimming test (FST) and tail suspension test (TST) were used to reveal the antidepressant-like effect of tetrandrine. Potential mechanisms were explored applying reserpine-induced ptosis and hypothermia in mice, as well as using the chronic unpredictable mild stress (CUMS) induced depression model in rats. Tetrandrine reduced immobility time in both the FST and TST and antagonized reserpine-induced ptosis and hypothermia in mice. The concentrations of 5-hydroxytryptamine (5-HT) and norepinephrine (NE) in mice hippocampi decreased after the administration of reserpine. However, pre-treatments with tetrandrine significantly increased the concentrations of 5-HT and NE in mice hippocampi. In the CUMS-induced depressive rats, bodyweight, 1% sucrose consumption and the concentrations of 5-HT and NE in hippocampi decreased significantly compared with the normal control group. However, these changes could be significantly reversed by tetrandrine application. Furthermore, the levels of the brain-derived neurotrophic factor (BDNF) in hippocampi increased in the tetrandrine-treated rats exposed to CUMS. In summary, our findings suggest that the antidepressant-like effect of tetrandrine is involved in the regulation of the central monoaminergic neurotransmitter system and the levels of BDNF.
authors.affiliation: Tianjin State Key Laboratory of Modern Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, PR China.
authors.forename: Shan
authors.initials: S
authors.lastname: Gao
authors.forename: Yuan-Lu
authors.initials: YL
authors.lastname: Cui
authors.forename: Chun-Quan
authors.initials: CQ
authors.lastname: Yu
authors.forename: Qiang-Song
authors.initials: QS
authors.lastname: Wang
authors.forename: Ye
authors.initials: Y
authors.lastname: Zhang
mesh_terms: D000818:Animals; D000928:Antidepressive Agents / Q000494:pharmacology / Q000627:therapeutic use*; D001522:Behavior, Animal / Q000187:drug effects*; D044182:Benzylisoquinolines / Q000494:pharmacology / Q000627:therapeutic use*; D019208:Brain-Derived Neurotrophic Factor / Q000378:metabolism*; D003866:Depressive Disorder / Q000188:drug therapy* / Q000378:metabolism; D004195:Disease Models, Animal; D019417:Hindlimb Suspension; D006624:Hippocampus / Q000187:drug effects / Q000378:metabolism; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D009043:Motor Activity / Q000187:drug effects; D009638:Norepinephrine / Q000378:metabolism; D051381:Rats; D017207:Rats, Sprague-Dawley; D012701:Serotonin / Q000378:metabolism; D013315:Stress, Psychological / Q000188:drug therapy / Q000378:metabolism; D013550:Swimming
chemical_list: D000928:Antidepressive Agents; D044182:Benzylisoquinolines; D019208:Brain-Derived Neurotrophic Factor; C009438:tetrandrine; D012701:Serotonin; D009638:Norepinephrine