title: Gd complexes of diethylenetriaminepentaacetic acid conjugates of low-molecular-weight chitosan oligosaccharide as a new liver-specific MRI contrast agent.
abstract: This study was to describe the synthesis of complexes of gadolinium diethylenetriaminepentaacetic acid conjugates of low-molecular-weight chitosan oligosaccharide Gd-DTPA-CSn (n=6, 8, 11) as a new class of contrast agent as well as its magnetic property in a pilot magnetic resonance imaging. The efficacy of the contrast agent was assessed by measuring the longitudinal relaxivity (r1), FLASH imaging in phantoms in vitro and signal intensity in vivo of the rat abdominal axial imaging. The r1 of Gd-DTPA-CS11 was up to 11.65 mM(-1)·s(-1), which was 3 times higher than that of the analogous MRI contrast agent Gd-DTPA in commercial use. In vivo MR images of rat obtained with Gd-DTPA-CS11 showed strong signal enhancement in liver and the vessels of the liver parenchyma during the extended period of time. The present study suggests that the new synthesized gadolinium complexes can be used as a new class of practical liver-specific MRI contrast agent because of its superior performance compared with Gd-DTPA.
authors.affiliation: School of Food and Biological Engineering, Jiangsu University, Zhenjiang, Jiangsu 212013, China. ujshxhg001@yahoo.com
authors.forename: Yan
authors.initials: Y
authors.lastname: Huang
authors.forename: Bennan
authors.initials: B
authors.lastname: Cao
authors.forename: Xiaolu
authors.initials: X
authors.lastname: Yang
authors.forename: Qi
authors.initials: Q
authors.lastname: Zhang
authors.forename: Xiangjun
authors.initials: X
authors.lastname: Han
authors.forename: Ziyi
authors.initials: Z
authors.lastname: Guo
mesh_terms: D000818:Animals; D048271:Chitosan / Q000138:chemical synthesis*; D003287:Contrast Media / Q000138:chemical synthesis; D004337:Drug Carriers / Q000138:chemical synthesis*; D019786:Gadolinium DTPA / Q000737:chemistry; D008099:Liver / Q000033:anatomy & histology*; D008279:Magnetic Resonance Imaging / Q000295:instrumentation / Q000379:methods*; D008970:Molecular Weight; D009844:Oligosaccharides / Q000138:chemical synthesis*; D019047:Phantoms, Imaging; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D003287:Contrast Media; D004337:Drug Carriers; D009844:Oligosaccharides; D048271:Chitosan; D019786:Gadolinium DTPA