title: Factor X inhibitor: a fulminant presentation and fatal course of a rare syndrome in a 59-year-old male.
abstract: Factor X inhibitors are rare. The few cases documented in the literature have occurred after viral prodromes, in association with cancer, or after exposure to antibiotics. Acquired factor X deficiencies are also rare and their etiology is largely unknown. We report a new case of a factor X inhibitor and review prior cases of both factor X inhibitors and non-amyloidosis-related acquired factor X deficiencies.
authors.affiliation: Cancer and Blood Specialists of Nevada, Henderson, NV 89074, USA. rgollard@hotmail.com
authors.forename: Russell
authors.initials: R
authors.lastname: Gollard
authors.forename: Syed
authors.initials: S
authors.lastname: Rahman
authors.forename: Ramalingam
authors.initials: R
authors.lastname: Ratnasabapathy
mesh_terms: D000890:Anti-Infective Agents / Q000627:therapeutic use; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D058846:Antibodies, Monoclonal, Murine-Derived / Q000627:therapeutic use; D002939:Ciprofloxacin / Q000627:therapeutic use; D003520:Cyclophosphamide / Q000627:therapeutic use; D015942:Factor VIIa / Q000627:therapeutic use; D005170:Factor X / Q000037:antagonists & inhibitors* / Q000378:metabolism; D005171:Factor X Deficiency / Q000175:diagnosis* / Q000188:drug therapy; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D010314:Partial Thromboplastin Time; D010951:Plasma Exchange; D011241:Prednisone / Q000627:therapeutic use; D011994:Recombinant Proteins / Q000627:therapeutic use; D012141:Respiratory Tract Infections / Q000188:drug therapy; D000069283:Rituximab; D018805:Sepsis / Q000175:diagnosis / Q000209:etiology / Q000382:microbiology; D013203:Staphylococcal Infections / Q000175:diagnosis / Q000382:microbiology; D013211:Staphylococcus aureus / Q000302:isolation & purification; D013577:Syndrome
chemical_list: D000890:Anti-Infective Agents; D000893:Anti-Inflammatory Agents; D058846:Antibodies, Monoclonal, Murine-Derived; D007166:Immunosuppressive Agents; D011994:Recombinant Proteins; D000069283:Rituximab; D002939:Ciprofloxacin; D003520:Cyclophosphamide; D005170:Factor X; C103587:recombinant FVIIa; D015942:Factor VIIa; D011241:Prednisone