title: Antidiabetic and antioxidant effects of Picrorhiza kurrooa rhizome extracts in diabetic rats.
abstract: Picrorhiza kurrooa is mentioned in Ayurveda for the treatment of many disorders, but it has not been subjected to systematic scientific investigations to assess its antidiabetic effect. The oral administration of aqueous and methanol extracts of P. kurrooa rhizomes (250 and 500 mg / kg body weight / day) for 15 days significantly reduced blood glucose, glycosylated haemoglobin and increased total hemoglobin, plasma insulin in alloxan-induced diabetes in albino rats. The treatment also showed significant correction in the level of nitric oxide radicals, superoxide radicals, peroxynitrite radical, lipid peroxidation, glutathione, glutathione reductase, glutathione-S-transferase, glutathione peroxidase, superoxide dismutase and catalase in the pancreas of alloxan diabetic rats.
authors.affiliation: Department of Biochemistry, Nagpur University, L.I.T. Premises, Amravati Road, Nagpur, 440010 India  ; Eugeniks Genetic Research Institute, Lokmat Bhavan, Ramdaspeth, Nagpur, 440012 India.
authors.forename: Shivkumar
authors.initials: S
authors.lastname: Chauhan
authors.forename: Nirmalendu
authors.initials: N
authors.lastname: Nath
authors.forename: Vinay
authors.initials: V
authors.lastname: Tule
keywords: Alloxan; Antidiabetic; Antioxidant; Picrorhiza kurrooa