title: Physical therapy and psychological intervention normalize cortisol levels and improve vitality in women with endometriosis.
abstract: There is as yet no effective treatment for endometriosis. The objective of this study was to evaluate the effectiveness of submitting women with endometriosis and chronic pelvic pain to a therapeutic protocol involving physical and psychological therapy. Twenty-six female volunteers were submitted to a treatment protocol consisting of 2.5-h sessions, once a week for 10 weeks. We applied a Visual Analogue Scale, the Perceived Stress Questionnaire (PSQ), and the Medical Outcomes Study 36-Item Short-Form Health Survey (SF-36). Morning, afternoon, and evening levels of cortisol were determined in saliva samples. The PSQ scores were significantly lower after treatment, whereas the scores for the SF-36 vitality and physical functioning domains were significantly higher. Salivary cortisol levels were higher after treatment in the samples collected in the morning, but not in those collected in the afternoon or evening. The post-treatment cortisol levels were similar to those reported for healthy women. There were positive correlations between vitality, role emotional, social functioning, and mental health, and negative correlations to perceived stress. In conclusion, the physical and psychological intervention protocol applied in this study to women suffering of endometriosis was effective in reducing perceived stress, normalizing cortisol levels, increasing vitality and improving physical functioning.
authors.affiliation: Department of Bioscience, Federal University of São Paulo (UNIFESP), Santos, Brazil.
authors.forename: Karina
authors.initials: K
authors.lastname: Friggi Sebe Petrelluzzi
authors.forename: Marcia Carvalho
authors.initials: MC
authors.lastname: Garcia
authors.forename: Carlos Alberto
authors.initials: CA
authors.lastname: Petta
authors.forename: Daniel Araki
authors.initials: DA
authors.lastname: Ribeiro
authors.forename: Nancy Ramacciotti
authors.initials: NR
authors.lastname: de Oliveira Monteiro
authors.forename: Isabel Cristina
authors.initials: IC
authors.lastname: Céspedes
authors.forename: Regina Celia
authors.initials: RC
authors.lastname: Spadari
mesh_terms: D000328:Adult; D001938:Brazil; D003131:Combined Modality Therapy; D004715:Endometriosis / Q000378:metabolism* / Q000517:prevention & control / Q000628:therapy*; D005081:Exercise Therapy / Q000379:methods*; D005260:Female; D015438:Health Behavior; D006266:Health Education / Q000379:methods; D006801:Humans; D006854:Hydrocortisone / Q000378:metabolism*; D008875:Middle Aged; D010809:Physical Fitness; D016387:Women's Health
chemical_list: D006854:Hydrocortisone