title: Adipokine hormones and hand osteoarthritis: radiographic severity and pain.
abstract: BACKGROUND
  Obesity's association with hand osteoarthritis cannot be fully explained by mechanical loading. We examined the relationship between adipokines and radiographic hand osteoarthritis severity and pain.
  
  
  METHODS
  In a pilot study of 44 hand osteoarthritis patients (39 women and 5 men), serum adipokine concentrations and hand x-ray Kallman-scores were analyzed using linear regression models. Secondary analyses examined correlates of hand pain.
  
  
  RESULTS
  The cohort had a mean age of 63.5 years for women and 72.6 for men; mean (standard deviation) Kallman-scores were 43.3(17.4) for women and 46.2(10.8) for men. Mean body-mass-index was 30 kg/m(2) for women and men. Mean leptin concentration was 32.2 ng/ml (women) and 18.5 ng/ml (men); mean adiponectin-total was 7.9 ng/ml (women) and 5.3 ng/ml (men); mean resistin was 7.3 ng/ml (women) and 9.4 ng/ml (men). No association was found between Kallman-scores and adipokine concentrations (R(2) = 0.00-0.04 unadjusted analysis, all p-values>0.22). Secondary analyses showed mean visual-analog-scale pain of 4.8(2.4) for women and 6.6(0.9) for men. Leptin, BMI, and history of coronary artery disease were found to be associated with visual-analog-scale scores for chronic hand pain (R(2) = 0.36 unadjusted analysis, p-values≤0.04).
  
  
  CONCLUSIONS
  In this pilot study, we found that adipokine serum concentrations were not associated with hand osteoarthritis radiographic severity; the most important correlates of joint damage were age and disease duration. Leptin serum concentration, BMI, and coronary artery disease were associated with the intensity of chronic hand OA pain.
authors.affiliation: Division of Rheumatology, Immunology, and Allergy, Brigham and Women's Hospital, Boston, Massachusetts, United States of America. hmei@partners.org
authors.forename: Mei
authors.initials: M
authors.lastname: Massengale
authors.forename: Bing
authors.initials: B
authors.lastname: Lu
authors.forename: John J
authors.initials: JJ
authors.lastname: Pan
authors.forename: Jeffrey N
authors.initials: JN
authors.lastname: Katz
authors.forename: Daniel H
authors.initials: DH
authors.lastname: Solomon
mesh_terms: D000367:Age Factors; D000368:Aged; D015992:Body Mass Index; D015331:Cohort Studies; D003324:Coronary Artery Disease / Q000097:blood* / Q000150:complications; D005260:Female; D006225:Hand / Q000473:pathology*; D006801:Humans; D007301:Insect Hormones / Q000097:blood*; D020738:Leptin / Q000097:blood; D016014:Linear Models; D008297:Male; D008875:Middle Aged; D059352:Musculoskeletal Pain / Q000209:etiology / Q000473:pathology*; D009842:Oligopeptides / Q000097:blood*; D010003:Osteoarthritis / Q000150:complications / Q000000981:diagnostic imaging*; D011761:Pyrrolidonecarboxylic Acid / Q000031:analogs & derivatives* / Q000097:blood; D011859:Radiography; D052243:Resistin / Q000097:blood
chemical_list: D007301:Insect Hormones; D020738:Leptin; D009842:Oligopeptides; D052243:Resistin; C044833:adipokinetic hormone; D011761:Pyrrolidonecarboxylic Acid