title: Serum uric Acid level and diverse impacts on regional arterial stiffness and wave reflection.
abstract: BACKGROUND
  Both increased arterial stiffness and hyperuricaemia are associated with elevated cardiovascular risks. Little is known about the relations of serum uric acid (UA) level to regional arterial stiffness and wave reflection. The aim of the study was to investigate the gender-specific association of serum UA and indices of arterial function in a community-based investigation in China.
  
  
  METHODS
  Cross-sectional data from 2374 adults (mean age 58.24 years) who underwent routine laboratory tests, regional pulse wave velocity (PWV) and pulse wave analysis measurements were analyzed in a gender-specific manner. None of the participants had atherosclerotic cardiovascular disease, chronic renal failure, systemic inflammatory disease, gout, or were under treatment which would affect serum UA level.
  
  
  RESULTS
  Men had higher serum UA level than women. Subjects with hyperuricaemia had significantly higher carotid-ankle PWV in both genders (P< 0.05), and the carotid-femoral PWV (PWVc-f) was higher in women (P< 0.001) while the augmentation index was marginally lower in men (P = 0.049). Multiple regression analysis showed that serum UA was an independent determinant only for PWVc-f in women (β = 0.104, P = 0.027) when adjusted for atherogenic confounders. No other independent relationship was found between UA level and other surrogates of arterial stiffness.
  
  
  CONCLUSIONS
  Serum UA levels are associated with alterations in systemic arterial stiffness that differ in men and women. Women might be more susceptible to large vascular damage associated with hyperuricaemia.
authors.affiliation: The Second Department of Geriatric Cardiology, General Hospital of the People's Liberation Army, Beijing, China.
authors.forename: Suyan
authors.initials: S
authors.lastname: Bian
authors.forename: Hongyang
authors.initials: H
authors.lastname: Guo
authors.forename: Ping
authors.initials: P
authors.lastname: Ye
authors.forename: Leiming
authors.initials: L
authors.lastname: Luo
authors.forename: Hongmei
authors.initials: H
authors.lastname: Wu
authors.forename: Wenkai
authors.initials: W
authors.lastname: Xiao
keywords: Arterial stiffness; Gender; Public health; Pulse wave velocity; Uric acid; Wave reflection