title: The effects of telmisartan and amlodipine in treatment-naïve and previously treated hypertensive patients: a subanalysis from a 4 × 4 factorial design study.
abstract: The subanalysis of a 4 × 4 factorial, 8-week study to evaluate the efficacy and tolerability of telmisartan (T) 40-80 mg/amlodipine (A) 5-10 mg used in treatment-naïve patients (n = 231) and patients previously treated with antihypertensive agents (n = 880). Similar blood pressure (BP) reductions were achieved with T + A, regardless of their pretreatment status. Highest reductions were achieved with T80 + A10 (treatment-naïve -26.5/-18.2 mm Hg and previously treated -25.6/-19.9 mm Hg). Most patients (treatment-naïve 72.4% and previously treated 77.6%), including those with added risk, achieved BP goal (<140/90 mm Hg) with T80 + A10. Tolerability was comparable in both groups.
authors.affiliation: Punzi Medical Center and Trinity Hypertension Research Institute, 1932 Walnut Plaza, Carrollton, TX 75006, USA. punzimedcenter@aol.com
authors.forename: Henry A
authors.initials: HA
authors.lastname: Punzi
authors.forename: Björn
authors.initials: B
authors.lastname: Dahlöf
authors.forename: Dave
authors.initials: D
authors.lastname: Webster
authors.forename: Claudio R
authors.initials: CR
authors.lastname: Majul
authors.forename: Wille
authors.initials: W
authors.lastname: Oigman
authors.forename: Rafael
authors.initials: R
authors.lastname: Olvera
authors.forename: Mary
authors.initials: M
authors.lastname: Seeber
authors.forename: Maureen
authors.initials: M
authors.lastname: Kobe
authors.forename: Helmut
authors.initials: H
authors.lastname: Schumacher
mesh_terms: D000328:Adult; D000368:Aged; D017311:Amlodipine / Q000009:adverse effects / Q000494:pharmacology / Q000627:therapeutic use*; D000959:Antihypertensive Agents / Q000009:adverse effects / Q000494:pharmacology / Q000627:therapeutic use*; D001562:Benzimidazoles / Q000009:adverse effects / Q000494:pharmacology / Q000627:therapeutic use*; D001565:Benzoates / Q000009:adverse effects / Q000494:pharmacology / Q000627:therapeutic use*; D001794:Blood Pressure / Q000187:drug effects / Q000502:physiology; D004305:Dose-Response Relationship, Drug; D004311:Double-Blind Method; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D006973:Hypertension / Q000188:drug therapy* / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D000077333:Telmisartan; D016896:Treatment Outcome
chemical_list: D000959:Antihypertensive Agents; D001562:Benzimidazoles; D001565:Benzoates; D017311:Amlodipine; D000077333:Telmisartan