title: [Functional state of the liver at modeling hemodynamic effects of the weightlessness in human organism].
abstract: The radioisotope researches (RR) ofcholeresis function of a liver, the ultrasonic researches (USR) of a liver, the contractile gallbladder function (GF) and the gastroduodenoscopy (GDS) were carried out at 8 men after 24 hour duration of stay in antiorthostatic position--12 degrees (AOP), simulating arising in weightlessness of hemodynamics changes in abdominal cavity. The dynamic difficulty of venous blood outflow from a liver at simulated in antiorthostatic position changes of activation choleresis on an empty stomach was produced, by increase of a zone central perfusion of a liver parenchyma, biliary ductules dilation and of a gallbladder reduction, and were accompanied by choleresis in duodenum. The activation choleresis in a liver was accompanied by of reduction of the area of radioactive marker distribution in a liver, the decrease of hepatocytes metabolic activity and concentration function ofbiliary excretion system. Specificity of a functional condition of a liver within AOP reflects reaction caused by plethoric changes induced by body position, which is negative to vector of gravity. The mechanism of the revealed changes includes occurrence dynamic venous plethora in a liver, centralization hepatic blood flow with activation choleresis activity against the background tissual blood flow depletion in peripheral zones, reduction of hepatocytes metabolic activity and concentration function biliary excretion system.
authors.forename: B V
authors.initials: BV
authors.lastname: Afonin
authors.forename: A E
authors.initials: AE
authors.lastname: Ermolenko
authors.forename: S L
authors.initials: SL
authors.lastname: Inozemtsev
mesh_terms: D000328:Adult; D001783:Blood Flow Velocity; D006439:Hemodynamics; D022781:Hepatocytes / Q000378:metabolism; D006801:Humans; D008099:Liver / Q000098:blood supply* / Q000000981:diagnostic imaging / Q000378:metabolism*; D008297:Male; D008955:Models, Cardiovascular; D014463:Ultrasonography; D014893:Weightlessness