title: Effect of methanolic fraction of Kalanchoe crenata on metabolic parameters in adriamycin-induced renal impairment in rats.
abstract: OBJECTIVE
  To investigate the effect of Kalanchoe crenata methanolic fraction (MEKC) on proteinuria, glucosuria, and some other biochemical parameters in adriamycin-induced renal impairment in rats.
  
  
  METHODS
  Ether anesthetized rats received three intravenous injections (days 0, 14, and 28) of 2 mg/kg body weight of adriamycin. Repeated doses of the extract (0, 50, and 68 mg/kg b.w.) and losartan (10 mg/kg b.w.) were administered orally once daily, for 6 weeks, to these rats. Kidney functions were assessed through biochemical parameters.
  
  
  RESULTS
  MEKC decreased proteinuria and also the urinary excretion of creatinine, glucose, and urea significantly in diseased rats. A decrease in serum levels of creatinine, urea, potassium, alkaline phosphatase, conjugate bilirubin, and alanine transaminase level was also recorded in nephropathic rats, but plasma levels of uric acid and glucose remained unchanged. Moreover, the plant extract markedly (P < 0.05) increased plasma sodium and decreased (P < 0.01) the urinary sodium and potassium levels.
  
  
  CONCLUSIONS
  The results indicated that the treatment with the methanolic fraction of K. crenata may improve proteinuria and all other symptoms due to adriamycin-induced nephropathy and, more than losartan, could ameliorate kidney and liver functions. K. crenata could be a potential source of new oral antinephropathic drug.
authors.affiliation: Laboratory of Endocrinology and Radioisotopes, Institute of Medical Research and Medicinal Plants Studies (IMPM), Yaoundé-Cameroon.
authors.forename: René
authors.initials: R
authors.lastname: Kamgang
authors.forename: Angèle F
authors.initials: AF
authors.lastname: Foyet
authors.forename: Jean-Louis O
authors.initials: JL
authors.lastname: Essame
authors.forename: Jeanne Y
authors.initials: JY
authors.lastname: Ngogang
mesh_terms: D000818:Animals; D004317:Doxorubicin / Q000633:toxicity*; D031962:Kalanchoe; D007674:Kidney Diseases / Q000139:chemically induced* / Q000188:drug therapy* / Q000378:metabolism; D008297:Male; D000432:Methanol / Q000302:isolation & purification / Q000627:therapeutic use*; D051379:Mice; D035261:Plant Components, Aerial; D010936:Plant Extracts / Q000302:isolation & purification / Q000627:therapeutic use*; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar; D016896:Treatment Outcome
chemical_list: D010936:Plant Extracts; D004317:Doxorubicin; D000432:Methanol
keywords: Adriamycin; Kalanchoe crenata methanolic extract; antioxidant effect; nephropathy; rat