title: Role of nicotinic and muscarinic cholinoreceptors in the realization of the cholinergic anti-inflammatory pathway during the early phase of sepsis.
abstract: Stimulation of nicotinic and muscarinic cholinoreceptors (nAChR, mAChR) in outbred albino mice with nicotine and aceclidine, respectively, in single equilethal doses 0.5 DL(50)6 h before sepsis induction significantly reduced animal mortality due to a decrease in blood concentrations of proinflammatory cytokines IL-1β, IL-6, and MIP-2. Stimulation of mAChR (injection of aceclidine) stimulated the neutrophilic phagocytic and metabolic activity. Realization of the cholinergic anti-inflammatory pathway (stimulation of the peripheral nicotinic cholinoreceptors (α7nAChR) and central muscarinic cholinoreceptors (mAChR) was modulated by stimulation of the muscarinic cholinoreceptors of the phagocytic monocytic system cells.
authors.affiliation: VI Razumovskii State Medical University, Saratov, Russia. pfzabrodsky@gmail.com
authors.forename: P F
authors.initials: PF
authors.lastname: Zabrodskii
authors.forename: V G
authors.initials: VG
authors.lastname: Lim
authors.forename: M S
authors.initials: MS
authors.lastname: Shekhter
authors.forename: A V
authors.initials: AV
authors.lastname: Kuzmin
mesh_terms: D000818:Animals; D016207:Cytokines / Q000097:blood; D004797:Enzyme-Linked Immunosorbent Assay; D051379:Mice; D009000:Monocytes / Q000187:drug effects; D009538:Nicotine / Q000494:pharmacology; D010587:Phagocytosis / Q000187:drug effects; D011812:Quinuclidines / Q000494:pharmacology; D011976:Receptors, Muscarinic / Q000378:metabolism*; D011978:Receptors, Nicotinic / Q000378:metabolism*; D018805:Sepsis / Q000503:physiopathology*; D015398:Signal Transduction / Q000187:drug effects* / Q000502:physiology
chemical_list: D016207:Cytokines; D011812:Quinuclidines; D011976:Receptors, Muscarinic; D011978:Receptors, Nicotinic; C084650:aceclidine; D009538:Nicotine