title: Insights on personalized medicine from Ayurveda.
abstract: The "omics" era of research has provided vital information on the genetic and biochemical diversity of individuals. This has lead to the emergence of "personalized medicine," wherein one aims to design specific drugs for individual patients or subtypes of patients. Indeed, the ongoing patent wars on this matter, suggest that personalized medicine represents a major goal for today's pharmaceutical industries. Although the concept of personalized medicine is new to modern medicine, it is a well-established concept in Ayurveda, the traditional system of Indian medicine that is still being practiced. Therefore, this article discusses topics that are crucial for the advancement of modern personalized medicine. These topics include disease susceptibility, disease subtypes, and Ayurvedic therapeutics. First, we explain how Ayurveda, Traditional Chinese Medicine, and Traditional Korean medicine or Sasang Constitutional medicine; conceptualize disease susceptibility and disease subtypes. Next, we focus on conceptual similarities between molecular medicine and Ayurvedic concepts of disease susceptibility and disease subtypes. For each topic, we explain the relevant experimental evidence reported in the literature. We also propose new hypotheses and suggest experimental approaches for their testing and validation.
authors.affiliation: Department of Biotechnology, Indian Institute of Technology-Madras, India. venil.sumantran@gmail.com
authors.forename: Venil N
authors.initials: VN
authors.lastname: Sumantran
authors.forename: Girish
authors.initials: G
authors.lastname: Tillu
mesh_terms: D003937:Diagnosis, Differential; D004198:Disease Susceptibility; D006801:Humans; D008515:Medicine, Ayurvedic; D008516:Medicine, Chinese Traditional; D055670:Medicine, Korean Traditional; D062346:Molecular Medicine; D057285:Precision Medicine