title: Proliferative response of lymphocyte to pokeweed mitogen depends on the concentration of endogenous cortisol in the early post-traumatic period in patients with penetrating eye injury.
abstract: The intensity of lymphocyte proliferation in response to pokeweed mitogen depends on cortisol level in the peripheral blood in the early post-traumatic period of penetrating eye injury. Lymphocyte proliferation in 72- and 96-h cultures from patients with high levels of endogenous hormone was suppressed. In 120-h cultures, the intensity of proliferation remains unchanged. Lymphocyte blast transformation was increased in 120-h cultures from patients with normal cortisol concentration and remained unchanged in case of low cortisol level.
authors.affiliation: Institute of Ecology and Genetics of Microorganisms, Ural Division of the Russian Academy of Sciences, Perm, Russia.
authors.forename: V A
authors.initials: VA
authors.lastname: Chereshnev
authors.forename: Ju I
authors.initials: JI
authors.lastname: Shilov
authors.forename: T V
authors.initials: TV
authors.lastname: Gavrilova
authors.forename: V V
authors.initials: VV
authors.lastname: Usov
authors.forename: M V
authors.initials: MV
authors.lastname: Chereshneva
mesh_terms: D000328:Adult; D049109:Cell Proliferation / Q000187:drug effects*; D004797:Enzyme-Linked Immunosorbent Assay; D015807:Eye Injuries, Penetrating / Q000097:blood / Q000276:immunology*; D006801:Humans; D006854:Hydrocortisone / Q000097:blood*; D008213:Lymphocyte Activation / Q000276:immunology* / Q000502:physiology; D008297:Male; D008875:Middle Aged; D011043:Pokeweed Mitogens / Q000494:pharmacology*; D013997:Time Factors
chemical_list: D011043:Pokeweed Mitogens; D006854:Hydrocortisone