title: Genetic Association Analysis of Dopamine DRD3 Ser9Gly Polymorphism and Schizophrenia in Malay Population.
abstract: BACKGROUND
  Molecular components of the dopamine receptor (DRD3) play an important role in the pathophysiology of schizophrenia (SCZ). Previous studies have demonstrated an association between the DRD3 Ser9Gly polymorphism and SCZ but the results have been inconclusive.
  
  
  METHODS
  In this study, we investigated this controversial association between the Ser9Gly (A/G) polymorphism and SCZ using Malay cases-control (261 cases/157 controls) samples. PCR-RFLP was performed to genotype the distribution of the DRD3 Ser9Gly polymorphism.
  
  
  RESULTS
  Both healthy control and SCHZ patient groups were in of Hardy-Weinberg equilibrium for the analyzed genetic variability. There was a significant association between the genotype distribution DRD3 polymorphisms and SCZ (χ(2)= 9.359; df = 2; P = 0.009).
  
  
  CONCLUSIONS
  We believe that further studies are required to examine the association between others dopamine-related genes and the behavioral phenotypes of SCZ.
authors.affiliation: Dept. of Chemical Engineering, Faculty of Engineering and Science, Universiti Tunku Abdul Rahman (UTAR), Jalan Genting Kelang, Setapak, 53300, Kuala Lumpur, Malaysia.
authors.forename: Sf
authors.initials: S
authors.lastname: Tee
authors.forename: Py
authors.initials: P
authors.lastname: Tang
authors.forename: Hc
authors.initials: H
authors.lastname: Loh
keywords: Dopamine receptor; Restriction fragment length polymorphism; Schizophrenia; Single nucleotide polymorphism