title: Mind bomb-1 is an essential modulator of long-term memory and synaptic plasticity via the Notch signaling pathway.
abstract: BACKGROUND
  Notch signaling is well recognized as a key regulator of the neuronal fate during embryonic development, but its function in the adult brain is still largely unknown. Mind bomb-1 (Mib1) is an essential positive regulator in the Notch pathway, acting non-autonomously in the signal-sending cells. Therefore, genetic ablation of Mib1 in mature neuron would give valuable insight to understand the cell-to-cell interaction between neurons via Notch signaling for their proper function.
  
  
  RESULTS
  Here we show that the inactivation of Mib1 in mature neurons in forebrain results in impaired hippocampal dependent spatial memory and contextual fear memory. Consistently, hippocampal slices from Mib1-deficient mice show impaired late-phase, but not early-phase, long-term potentiation and long-term depression without change in basal synaptic transmission at SC-CA1 synapses.
  
  
  CONCLUSIONS
  These data suggest that Mib1-mediated Notch signaling is essential for long-lasting synaptic plasticity and memory formation in the rodent hippocampus.
authors.affiliation: Department of Biological Sciences, College of Natural Sciences, Seoul National University, San 56-1 Silim-dong Gwanak-gu, Seoul 151-747, South Korea.
authors.forename: Ki-Jun
authors.initials: KJ
authors.lastname: Yoon
authors.forename: Hye-Ryeon
authors.initials: HR
authors.lastname: Lee
authors.forename: Yong Sang
authors.initials: YS
authors.lastname: Jo
authors.forename: Kyongman
authors.initials: K
authors.lastname: An
authors.forename: Sang-Yong
authors.initials: SY
authors.lastname: Jung
authors.forename: Min-Woo
authors.initials: MW
authors.lastname: Jeong
authors.forename: Seok-Kyu
authors.initials: SK
authors.lastname: Kwon
authors.forename: Nam-Shik
authors.initials: NS
authors.lastname: Kim
authors.forename: Hyun-Woo
authors.initials: HW
authors.lastname: Jeong
authors.forename: Seo-Hee
authors.initials: SH
authors.lastname: Ahn
authors.forename: Kyong-Tai
authors.initials: KT
authors.lastname: Kim
authors.forename: Kyungmin
authors.initials: K
authors.lastname: Lee
authors.forename: Eunjoon
authors.initials: E
authors.lastname: Kim
authors.forename: Joung-Hun
authors.initials: JH
authors.lastname: Kim
authors.forename: June-Seek
authors.initials: JS
authors.lastname: Choi
authors.forename: Bong-Kiun
authors.initials: BK
authors.lastname: Kaang
authors.forename: Young-Yun
authors.initials: YY
authors.lastname: Kong
mesh_terms: D000375:Aging / Q000378:metabolism; D000818:Animals; D006624:Hippocampus / Q000033:anatomy & histology / Q000201:enzymology; D017774:Long-Term Potentiation; D057567:Memory, Long-Term / Q000502:physiology*; D051379:Mice; D018345:Mice, Knockout; D009473:Neuronal Plasticity / Q000502:physiology*; D009474:Neurons / Q000378:metabolism; D010641:Phenotype; D011493:Protein Kinase C / Q000378:metabolism; D017434:Protein Structure, Tertiary; D051880:Receptors, Notch / Q000737:chemistry / Q000378:metabolism*; D015398:Signal Transduction; D013569:Synapses / Q000502:physiology*; D044767:Ubiquitin-Protein Ligases / Q000378:metabolism*; D000099221:Protein Kinase C zeta
chemical_list: D011493:Protein Kinase C; D051880:Receptors, Notch; D044767:Ubiquitin-Protein Ligases; D000099221:Protein Kinase C zeta; C470629:MIB1 protein, mouse