title: Development and optimization of hydroxyapatite-ofloxacin implants for possible bone delivery in osteomyelitis treatment.
abstract: The present study deals with preparation, optimization and in-vitro drug release study of hydroxyapatite (HAp)- ofloxacin for bone-implantable delivery in osteomyelitis treatment. The effect of drug amount added, and orthophosphoric acid addition rate as process parameters on the drug loading into HAp-system by precipitation method was optimized by using 32 factorial design. The response surface methodology utilizing polynomial equation was used to search for optimal drug loading into HAp-system. The responses observed coincided well with the predicted values obtained through optimization technique. HAp-ofloxacin bone-implants were manufactured using synthesized HAp-ofloxacin composite powders and 2 % w/v aqueous solution of sodium alginate was used as binder. Characterization of the delivery system was done by FTIR spectroscopy. The in-vitro ofloxacin release from optimized HAp-ofloxacin bone-implants was slow and sustained over 10 weeks. The drug release pattern was correlated well with Korsmeyer-Peppas model and was followed by Fickian (diffusional) release mechanism.
authors.affiliation: Department of Pharmaceutical Chemistry, Shivdan Singh Institute of Technology and Management, Aligarh, India.
authors.forename: Amit Kumar
authors.initials: AK
authors.lastname: Nayak
authors.forename: M Saquib
authors.initials: MS
authors.lastname: Hasnain
authors.forename: Jadupati
authors.initials: J
authors.lastname: Malakar
mesh_terms: D000900:Anti-Bacterial Agents / Q000008:administration & dosage* / Q000494:pharmacology / Q000627:therapeutic use; D001842:Bone and Bones / Q000187:drug effects*; D004343:Drug Implants; D017886:Durapatite / Q000008:administration & dosage*; D006801:Humans; D015242:Ofloxacin / Q000008:administration & dosage* / Q000494:pharmacology / Q000627:therapeutic use; D010019:Osteomyelitis / Q000188:drug therapy*
chemical_list: D000900:Anti-Bacterial Agents; D004343:Drug Implants; D017886:Durapatite; D015242:Ofloxacin