title: Mortality and hospital stay related to coagulase-negative Staphylococci bacteremia in non-critical patients.
abstract: OBJECTIVE
  To describe the morbidity and mortality related to coagulase-negative Staphylococci (CNS) bacteremia in non-critical patients.
  
  
  METHODS
  Prospective, matched case-control study nested in a cohort. Patients with CNS bacteremia and no other isolate in blood cultures during their admission were defined as cases. Each case was matched by age, sex and area of hospitalization to one control. A 30-day follow-up was performed. Mortality and hospital stay were defined as endpoints.
  
  
  RESULTS
  105 cases and 105 controls were included. All cases carried intravascular catheters at the time of inclusion. Cases presented higher mortality compared to controls (14.3% vs. 4.8%), although this association was not independent in a multivariate analysis (p = 0.11). CNS bacteremia was independently associated with longer hospital stay (mean 12 vs. 8.5 days, p = 0.008). Moreover, when patients with CNS bacteremia were specifically analyzed, the persistence of fever (p = 0.005) and inappropriate empirical treatment (p = 0.04) were independently related to mortality.
  
  
  CONCLUSIONS
  We did not observe increased mortality attributable to CNS bacteremia, although it was associated with longer hospitalizations. Early appropriate empirical antibiotic therapy pending blood culture results might improve the outcome of patients with CNS bacteremia. Close follow-up is recommended if fever persists beyond 72 h.
authors.affiliation: Clinical Unit of Infectious Diseases, Microbiology and Preventive Medicine, Institute of Biomedicine of Sevilla (IBiS), University Hospital Virgen del Rocío/CSIC/University of Sevilla, Av. Manuel Siurot s/n, 41013 Sevilla, Spain. josemolinagb@gmail.com
authors.forename: J
authors.initials: J
authors.lastname: Molina
authors.forename: I
authors.initials: I
authors.lastname: Peñuela
authors.forename: J A
authors.initials: JA
authors.lastname: Lepe
authors.forename: A
authors.initials: A
authors.lastname: Gutiérrez-Pizarraya
authors.forename: M J
authors.initials: MJ
authors.lastname: Gómez
authors.forename: E
authors.initials: E
authors.lastname: García-Cabrera
authors.forename: E
authors.initials: E
authors.lastname: Cordero
authors.forename: J
authors.initials: J
authors.lastname: Aznar
authors.forename: J
authors.initials: J
authors.lastname: Pachón
mesh_terms: D000328:Adult; D000368:Aged; D016470:Bacteremia; D003030:Coagulase / Q000172:deficiency*; D003428:Cross Infection; D006801:Humans; D007902:Length of Stay; D008875:Middle Aged; D012307:Risk Factors; D013203:Staphylococcal Infections / Q000453:epidemiology* / Q000401:mortality; D013210:Staphylococcus / Q000201:enzymology*
chemical_list: D003030:Coagulase