title: Association of the apolipoprotein M gene polymorphisms and serum lipid levels.
abstract: The association of rs707921 and rs707922 SNPs in the apolipoprotein M (APOM) gene and serum lipid levels is still controversial. This study aimed to detect the association of the APOM rs707921 and rs707922 SNPs and several environmental factors with serum lipid profiles. Genotyping of rs707921 and rs707922 was performed in 703 of Mulao's and 707 of Han's participants. The serum levels of TG in Mulao, and TG and HDL-C in Han were different between the A and C allele carriers of rs707921 (P < 0.05-0.01); while the serum levels of TG in both Mulao and Han were different between the T and G allele carriers of rs707922 (P < 0.05-0.01). According to the gender-subgroup analysis, the levels of TC in Mulao females, TG and ApoB in Han males, and HDL-C in Han females were associated with the genotypes of rs707921 (P < 0.05 for each); whereas the levels of TG in Mulao males, and TG and ApoB in Han males were correlated with the genotypes of rs707922 (P < 0.05 for each). Serum lipid parameters were also associated with several environmental factors (P < 0.05-0.001). The APOM gene rs707921 and rs707922 SNPs are associated with some serum lipid parameters in the two ethnic groups, but the trends of association suggest that the two SNPs might have racial/ethnic- and/or gender- specificity.
authors.affiliation: Department of Cardiology, Institute of Cardiovascular Diseases, The First Affiliated Hospital, Guangxi Medical University, Nanning, Guangxi, People's Republic of China. lifeinnivana@hotmail.com
authors.forename: Lynn Htet Htet
authors.initials: LH
authors.lastname: Aung
authors.forename: Rui-Xing
authors.initials: RX
authors.lastname: Yin
authors.forename: Dong-Feng
authors.initials: DF
authors.lastname: Wu
authors.forename: Ting-Ting
authors.initials: TT
authors.lastname: Yan
authors.forename: Qing
authors.initials: Q
authors.lastname: Li
authors.forename: Jin-Zhen
authors.initials: JZ
authors.lastname: Wu
authors.forename: Wei-Xiong
authors.initials: WX
authors.lastname: Lin
authors.forename: Cheng-Wu
authors.initials: CW
authors.lastname: Liu
authors.forename: Shang-Ling
authors.initials: SL
authors.lastname: Pan
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001053:Apolipoproteins / Q000235:genetics*; D000075243:Apolipoproteins M; D001483:Base Sequence; D002318:Cardiovascular Diseases / Q000097:blood / Q000235:genetics; D002681:China; D005260:Female; D005787:Gene Frequency; D059647:Gene-Environment Interaction; D056726:Genetic Association Studies; D006801:Humans; D008055:Lipids / Q000097:blood*; D054834:Lipocalins / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D008969:Molecular Sequence Data; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors; D012424:Rural Population; D017422:Sequence Analysis, DNA; D055815:Young Adult
chemical_list: C400523:APOM protein, human; D001053:Apolipoproteins; D000075243:Apolipoproteins M; D008055:Lipids; D054834:Lipocalins