title: Hyperuricemia and metabolic syndrome in children with overweight and obesity.
abstract: OBJECTIVE
  To study the prevalence of hyperuricemia in children with overweight or obesity and analyze the relation with metabolic syndrome and the diseases that define it.
  
  
  METHODS
  This is a cross-sectional prevalence study in 148 children recruited from pediatric endocrinology consultation, with overweight or obesity (12±3 years, 48% boys, BMI 31.8±6.1). We measured BMI, waist-height, waist circumference, blood pressure with standard instrumentation and glucose (fasting and after overload with 75 g), insulin resistance, cholesterol HDL, triglycerides and uric acid.
  
  
  RESULTS
  The prevalence of hyperuricemia was 53%. Patients with hyperuricemia had greater BMI (33.9 vs 30.6, p=0.003), plus waist circumference (101.4 vs 91.1cm, p<0.001), higher blood pressure: systolic (123.4 vs 111.9 mm Hg, p<0.001), diastolic (78.2 vs 68.7 mm Hg, p<0.001). They presented greater blood glucose after overload oral glucose (107.5 vs 100.7 mg/dl, p=0.03), insulin was higher (29.2 vs 20.7 mg/dl, p=0.001) as well as HOMA IR (6.5 vs 4.4, p<0.001) and HDL levels were lower (49.5 vs 54.4 mg/dl, p=0.02). Uric acid's level which most is the likely diagnosis of metabolic syndrome corresponds to 5.4 mg/dl in our sample (sensitivity: 64% and specificity 62%).
  
  
  CONCLUSIONS
  The prevalence of hyperuricemia in children with overweight and obesity is high. In the group of patients with obesity and hyperuricemia, we found out that the parameters measured to diagnose with metabolic syndrome were less favorable. Uric acid's level from where there is a higher possibility to see metabolic syndrome is 5.4 mg/dl.
authors.affiliation: Endocrinology and Nutrition, Getafe University Hospital, Madrid, Spain. zulemaciv@hotmail.com
authors.forename: Soralla
authors.initials: S
authors.lastname: Civantos Modino
authors.forename: M Guadalupe
authors.initials: MG
authors.lastname: Guijarro de Armas
authors.forename: Susana
authors.initials: S
authors.lastname: Monereo Mejías
authors.forename: July M
authors.initials: JM
authors.lastname: Montaño Martínez
authors.forename: Paloma
authors.initials: P
authors.lastname: Iglesias Bolaños
authors.forename: María
authors.initials: M
authors.lastname: Merino Viveros
authors.forename: Jose María
authors.initials: JM
authors.lastname: Ladero Quesada
mesh_terms: D000293:Adolescent; D000886:Anthropometry; D001794:Blood Pressure; D002648:Child; D015897:Comorbidity; D003430:Cross-Sectional Studies; D005215:Fasting / Q000097:blood; D005260:Female; D006801:Humans; D033461:Hyperuricemia / Q000097:blood / Q000453:epidemiology*; D007333:Insulin Resistance; D008055:Lipids / Q000097:blood; D008297:Male; D024821:Metabolic Syndrome / Q000097:blood / Q000453:epidemiology*; D009765:Obesity / Q000097:blood / Q000453:epidemiology; D050177:Overweight / Q000097:blood / Q000453:epidemiology*; D019518:Postprandial Period; D011236:Prediabetic State / Q000097:blood / Q000453:epidemiology; D015995:Prevalence; D012372:ROC Curve; D013030:Spain / Q000453:epidemiology
chemical_list: D008055:Lipids