title: Prospective memory and antiretroviral medication non-adherence in HIV: an analysis of ongoing task delay length using the memory for intentions screening test.
abstract: Using multi-process framework by McDaniel and Einstein (2000), the current study examined whether the length of prospective memory (PM) delay intervals as measured by the 2- and 15-min subscales of the Memory for Intentions Screening Test (MIST) have differential predictive value for antiretroviral (ARV) adherence. Participants included 74 HIV-infected individuals whose ARV adherence was tracked with an electronic monitoring system. Participants were classified as "adherent" (n = 49) or "non-adherent" (n = 25) based on recorded pill bottle openings of ≥90% of prescribed doses over 30 days. An adherence group by MIST delay interval interaction was observed, such that non-adherent participants had worse performance on the 15-min, but not 2-min delay PM MIST subscales. The observed MIST 15-min delay effects were significantly more pronounced on time- versus event-cued PM trials. Long-delay time-based PM was predictive of non-adherence independent of demographics, mood state, self-reported adherence, and general cognitive functioning. Findings from this clinical study indicate that ARV non-adherence may be particularly associated with deficits in strategic cue monitoring over longer PM delays, which may inform interventions to improve adherence among persons living with HIV infection.
authors.affiliation: Department of Psychiatry, University of California, San Diego, La Jolla, CA 92103, USA.
authors.forename: Amelia J
authors.initials: AJ
authors.lastname: Poquette
authors.forename: David J
authors.initials: DJ
authors.lastname: Moore
authors.forename: Ben
authors.initials: B
authors.lastname: Gouaux
authors.forename: Erin E
authors.initials: EE
authors.lastname: Morgan
authors.forename: Igor
authors.initials: I
authors.lastname: Grant
authors.forename: Steven Paul
authors.initials: SP
authors.lastname: Woods
mesh_terms: D000328:Adult; D000704:Analysis of Variance; D000998:Antiviral Agents / Q000009:adverse effects*; D016009:Chi-Square Distribution; D005260:Female; D015658:HIV Infections / Q000188:drug therapy / Q000503:physiopathology / Q000523:psychology; D006801:Humans; D033182:Intention; D008297:Male; D055118:Medication Adherence / Q000523:psychology*; D008569:Memory Disorders / Q000139:chemically induced* / Q000175:diagnosis; D061212:Memory, Episodic; D008875:Middle Aged; D011569:Psychiatric Status Rating Scales
chemical_list: D000998:Antiviral Agents