title: Stabilization and enhanced reactivity of actinorhodin polyketide synthase minimal complex in polymer-nucleotide coacervate droplets.
abstract: Compartmentalization of the minimal complex of actinorhodin polyketide synthase in coacervate liquid droplets produces enhanced yields of shunt polyketides under conditions of low and high ionic strength.
authors.affiliation: School of Chemistry, University of Bristol, Bristol, BS8 1TS, UK. john.crosby@bristol.ac.uk
authors.forename: John
authors.initials: J
authors.lastname: Crosby
authors.forename: Tom
authors.initials: T
authors.lastname: Treadwell
authors.forename: Michelle
authors.initials: M
authors.lastname: Hammerton
authors.forename: Konstantinos
authors.initials: K
authors.lastname: Vasilakis
authors.forename: Matthew P
authors.initials: MP
authors.lastname: Crump
authors.forename: David S
authors.initials: DS
authors.lastname: Williams
authors.forename: Stephen
authors.initials: S
authors.lastname: Mann
mesh_terms: D000255:Adenosine Triphosphate / Q000737:chemistry / Q000378:metabolism*; D004795:Enzyme Stability; D009994:Osmolar Concentration; D010316:Particle Size; D011095:Polyethylenes / Q000737:chemistry / Q000378:metabolism*; D048630:Polyketide Synthases / Q000737:chemistry / Q000378:metabolism*; D000644:Quaternary Ammonium Compounds / Q000737:chemistry / Q000378:metabolism*; D013499:Surface Properties
chemical_list: D011095:Polyethylenes; D000644:Quaternary Ammonium Compounds; C041004:poly-N,N-dimethyl-N,N-diallylammonium chloride; D048630:Polyketide Synthases; D000255:Adenosine Triphosphate; C087193:polyketide beta-ketoacylsynthase