title: Risk factors for delayed graft function in cardiac death donor renal transplants.
abstract: BACKGROUND
  Delayed graft function (DGF) is common in kidney transplants from organ donation after cardiac death (DCD) donors. It is associated with various factors. Determination of center-specific risk factors may help to reduce the incidence of DGF and improve the transplantation results. The aim of this study is to define risk factors of DGF after renal transplantation.
  
  
  METHODS
  From March 2010 to June 2012, 56 cases of recipients who received DCD kidneys were selected. The subjects were divided into two groups: immediate graft function (IGF) and DGF groups. Transplantation factors of donors and recipients as well as early post-transplant results of recipients were compared between the two groups.
  
  
  RESULTS
  On univariate analysis, preoperative dialysis time of recipients (P < 0.001), type of dialysis (P = 0.039), human leucocyte antigen (HLA) mismatch sites (P < 0.001), the cause of brain death (P = 0.027), body mass index (BMI) of donors (P < 0.001), preoperative infection (P = 0.002), preoperative serum creatinine of donors (P < 0.001), norepinephrine used in donors (P < 0.001), cardiopulmonary resuscitation (CPR) of donors (P < 0.001), warm ischemia time (WIT) (P < 0.001) and cold ischemia time (CIT) (P < 0.001) showed significant differences. Recipients who experienced DGF had a longer hospital stay, and higher level of postoperative serum creatinine.
  
  
  CONCLUSIONS
  Multiple risk factors are associated with DGF, which had deleterious effects on the early post-transplant period.
authors.affiliation: Research Center of Chinese Health Ministry of Transplantation Medicine Engineering and Technology, Third Affiliated Hospital, Central South University, Changsha, Hunan 410013, China.
authors.forename: Ming-Jie
authors.initials: MJ
authors.lastname: Shao
authors.forename: Qi-Fa
authors.initials: QF
authors.lastname: Ye
authors.forename: Ying-Zi
authors.initials: YZ
authors.lastname: Ming
authors.forename: Xing-Guo
authors.initials: XG
authors.lastname: She
authors.forename: Hong
authors.initials: H
authors.lastname: Liu
authors.forename: Shao-Jun
authors.initials: SJ
authors.lastname: Ye
authors.forename: Ying
authors.initials: Y
authors.lastname: Niu
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D016022:Case-Control Studies; D003643:Death; D051799:Delayed Graft Function / Q000209:etiology*; D005260:Female; D006801:Humans; D016030:Kidney Transplantation / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D012307:Risk Factors; D014019:Tissue Donors