title: Membrane interacting peptides: from killers to helpers.
abstract: Membrane interacting peptides are reviewed in terms of structure and mode of action on lipid membranes. Helical, β-stranded, peptides containing both helices and strands, cyclic, lipopeptides and short linear peptides are seen to considerably modulate membrane function. Among peptides that lead to membrane alteration or permeation, antimicrobial peptides play an important role and some of them may be foreseen as potential new antibiotics. Alternatively, peptides that do not destroy the membrane are also very important in modulating the structure and dynamics of the lipid bilayer and play important roles in membrane protein functions. Peptide lipid complexes are shown to be very variable in structure and dynamics: "carpet", "barrel stave", toroid and disordered pores, electrostatic wedge and molecular electroporation models are discussed. Their assembly is reviewed in terms of electric, amphipathic and dynamic properties of both lipids and peptides.
authors.affiliation: Institute of Chemistry & Biology of Membranes & Nanoobjects (CBMN), UMR5248, Université Bordeaux, CNRS Institut Polytechnique Bordeaux, Pessac, France. e.dufourc@iecb.u-bordeaux.fr
authors.forename: Erick J
authors.initials: EJ
authors.lastname: Dufourc
authors.forename: Sébastien
authors.initials: S
authors.lastname: Buchoux
authors.forename: Jeannot
authors.initials: J
authors.lastname: Toupé
authors.forename: Marc-Antoine
authors.initials: MA
authors.lastname: Sani
authors.forename: Frantz
authors.initials: F
authors.lastname: Jean-François
authors.forename: Lucie
authors.initials: L
authors.lastname: Khemtémourian
authors.forename: Axelle
authors.initials: A
authors.lastname: Grélard
authors.forename: Cécile
authors.initials: C
authors.lastname: Loudet-Courrèges
authors.forename: Michel
authors.initials: M
authors.lastname: Laguerre
authors.forename: Juan
authors.initials: J
authors.lastname: Elezgaray
authors.forename: Bernard
authors.initials: B
authors.lastname: Desbat
authors.forename: Benoit
authors.initials: B
authors.lastname: Odaert
mesh_terms: D000818:Animals; D000890:Anti-Infective Agents / Q000737:chemistry* / Q000378:metabolism; D023181:Antimicrobial Cationic Peptides / Q000737:chemistry* / Q000378:metabolism; D002463:Cell Membrane Permeability; D057846:Cell-Penetrating Peptides / Q000737:chemistry* / Q000378:metabolism; D006801:Humans; D057927:Hydrophobic and Hydrophilic Interactions; D055666:Lipopeptides / Q000737:chemistry* / Q000378:metabolism; D008563:Membrane Lipids / Q000737:chemistry* / Q000378:metabolism; D008958:Models, Molecular; D010456:Peptides, Cyclic / Q000737:chemistry* / Q000378:metabolism; D017433:Protein Structure, Secondary; D017434:Protein Structure, Tertiary; D055672:Static Electricity
chemical_list: D000890:Anti-Infective Agents; D023181:Antimicrobial Cationic Peptides; D057846:Cell-Penetrating Peptides; D055666:Lipopeptides; D008563:Membrane Lipids; D010456:Peptides, Cyclic