title: Antioxidant protection of the brain in rats during acute stress and administration of interleukin-1β.
abstract: We studied the effect of IL-1β on antioxidant enzyme activity in emotiogenic structures of the brain (hypothalamus, sensorimotor cortex, and amygdala) in behaviorally passive and active rats with different sensitivity to stress. One-hour immobilization of animals with simultaneous electrocutaneous stimulation was used as a model of stress. An intraperitoneal injection of IL-1β (5 μg/kg) was followed by the decrease in glutathione reductase activity in the hypothalamus of rats. Behaviorally active animals of the IL-1β group were characterized by an increase in the activities of Cu/Zn superoxide dismutase and glutathione peroxidase in the sensorimotor cortex and amygdala, respectively. IL-1β administration was accompanied by activation of Cu/Zn superoxide dismutase and glutathione peroxidase in the amygdala of passive rats. Pretreatment with IL-1β abolished the poststress changes in enzyme activity in the hypothalamus and sensorimotor cortex of active and passive rats, respectively. These data illustrate the specific effects of IL-1β on antioxidant protection of CNS tissues in rats with various behavioral characteristics.
authors.affiliation: PK Anokhin Institute of Normal Physiology, Russian Academy of Medical Sciences, Moscow, Russia. lkalina@yandex.ru
authors.forename: L S
authors.initials: LS
authors.lastname: Kalinichenko
authors.forename: S S
authors.initials: SS
authors.lastname: Pertsov
authors.forename: E V
authors.initials: EV
authors.lastname: Koplik
authors.forename: G V
authors.initials: GV
authors.lastname: Pirogova
mesh_terms: D000679:Amygdala / Q000378:metabolism*; D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D002540:Cerebral Cortex / Q000378:metabolism*; D004558:Electric Stimulation; D005979:Glutathione Peroxidase / Q000378:metabolism; D005980:Glutathione Reductase / Q000378:metabolism; D007031:Hypothalamus / Q000378:metabolism*; D007103:Immobilization; D007274:Injections, Intraperitoneal; D053583:Interleukin-1beta / Q000008:administration & dosage / Q000494:pharmacology*; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D013053:Spectrophotometry; D018709:Statistics, Nonparametric; D013312:Stress, Physiological / Q000502:physiology*; D013482:Superoxide Dismutase / Q000378:metabolism
chemical_list: D000975:Antioxidants; D053583:Interleukin-1beta; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase; D005980:Glutathione Reductase