title: Copper-assisted palladium(II)-catalyzed direct arylation of cyclic enaminones with arylboronic acids.
abstract: Described herein is a palladium(II)-catalyzed direct arylation of cyclic enaminones with arylboronic acids. The versatility of this method is that both electron-rich and electron-poor boronic acids can be coupled in high yields. A mixture of two Cu(II) additives was crucial for efficient cross-coupling. The role of each Cu(II) reagent appears to be distinct and complementary serving to assist catalyst reoxidation and transmetalation through a putative arylcopper intermediate.
authors.affiliation: Department of Chemistry, and the Institute for Therapeutics Discovery and Development, University of Minnesota, 717 Delaware Street SE, Minneapolis, Minnesota 55414, United States.
authors.forename: Yong Wook
authors.initials: YW
authors.lastname: Kim
authors.forename: Micah J
authors.initials: MJ
authors.lastname: Niphakis
authors.forename: Gunda I
authors.initials: GI
authors.lastname: Georg
mesh_terms: D000588:Amines / Q000737:chemistry*; D001897:Boronic Acids / Q000737:chemistry*; D002384:Catalysis; D003300:Copper / Q000737:chemistry*; D006571:Heterocyclic Compounds / Q000737:chemistry*; D015394:Molecular Structure; D010165:Palladium / Q000737:chemistry*
chemical_list: D000588:Amines; D001897:Boronic Acids; D006571:Heterocyclic Compounds; D010165:Palladium; D003300:Copper