title: Tissue inhibitors of matrix metalloproteinases 1 and 2 and matrix metalloproteinase activity in the serum and lungs of mice with lewis lung carcinoma.
abstract: We studied the content of tissue inhibitors of matrix metalloproteinases 1 and 2 (TIMP-1 and TIMP-2) and activities of matrix metalloproteinases (MMP) in the serum and lungs of mice with Lewis lung carcinoma metastasizing into the lung. Metastasizing was associated with increased serum content of TIMP-1 and TIMP-2 (only on day 20 at the terminal stage of the tumor process). These data confirm the hypothesis on pro-tumorigenic role of TIMP-1 in the serum. Locally, the development of metastases was associated with a decrease in TIPM-1 concentration (day 7), an increase in TIMP-2 concentration (days 7 and 20), and elevated activity of MMP at all terms of the study (days 7, 15, and 20). Increased concentration of TIMP-2 in the lungs (but not in the serum) can be regarded as an indicator of Lewis lung carcinoma metastasizing.
authors.affiliation: Institute of Physiology, Siberian Division of the Russian Academy of Medical Sciences, Novosibirsk. y_kisarova@physiol.ru
authors.forename: Ya A
authors.initials: YA
authors.lastname: Kisarova
authors.forename: T A
authors.initials: TA
authors.lastname: Korolenko
mesh_terms: D000818:Animals; D018827:Carcinoma, Lewis Lung / Q000097:blood / Q000235:genetics* / Q000473:pathology*; D015870:Gene Expression; D007273:Injections, Intramuscular; D008168:Lung / Q000378:metabolism* / Q000473:pathology; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D018482:Muscle, Skeletal / Q000473:pathology; D009361:Neoplasm Invasiveness; D019715:Tissue Inhibitor of Metalloproteinase-1 / Q000097:blood / Q000235:genetics*; D019716:Tissue Inhibitor of Metalloproteinase-2 / Q000097:blood / Q000235:genetics*; D014407:Tumor Cells, Cultured / Q000637:transplantation
chemical_list: C560825:Timp1 protein, mouse; D019715:Tissue Inhibitor of Metalloproteinase-1; D019716:Tissue Inhibitor of Metalloproteinase-2