title: Recent advances in topical ophthalmic drug delivery with lipid-based nanocarriers.
abstract: Ocular barriers and the poor water solubility of drug candidates present a number of problems for the development of ocular drug delivery systems. Recently, the emergence of lipid-based nanocarriers has provided a viable means of enhancing the bioavailability of ophthalmic formulations. A number of these formulations have been found to be clinically active and several others are currently undergoing clinical trials. In this review, the advantages of lipid-based nanocarriers as non-invasive topical ocular drug delivery systems are presented. Many systems, including emulsions, liposomes, cubosomes, niosomes and other lipid-based nanocarriers, are reviewed.
authors.affiliation: Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 501 Haike Road, Shanghai 201203, China.
authors.forename: Li
authors.initials: L
authors.lastname: Gan
authors.forename: Jing
authors.initials: J
authors.lastname: Wang
authors.forename: Min
authors.initials: M
authors.lastname: Jiang
authors.forename: Hanah
authors.initials: H
authors.lastname: Bartlett
authors.forename: Defang
authors.initials: D
authors.lastname: Ouyang
authors.forename: Frank
authors.initials: F
authors.lastname: Eperjesi
authors.forename: Jianping
authors.initials: J
authors.lastname: Liu
authors.forename: Yong
authors.initials: Y
authors.lastname: Gan
mesh_terms: D060433:Administration, Ophthalmic; D000818:Animals; D004337:Drug Carriers / Q000008:administration & dosage* / Q000737:chemistry; D006801:Humans; D008055:Lipids / Q000008:administration & dosage / Q000737:chemistry; D053758:Nanoparticles / Q000008:administration & dosage* / Q000737:chemistry; D009883:Ophthalmic Solutions / Q000008:administration & dosage* / Q000737:chemistry
chemical_list: D004337:Drug Carriers; D008055:Lipids; D009883:Ophthalmic Solutions