title: Palladium-catalyzed C-H functionalization using guanidine as a directing group: ortho arylation and olefination of arylguanidines.
abstract: Palladium-catalyzed C-H functionalization using guanidine as the directing group was achieved under mild reaction conditions. Various guanidine derivatives were produced in moderate to good yields by using simple unactivated arenes or ethyl acrylate as the source of arylation or olefination, respectively.
authors.affiliation: Institute of Materia Medica, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, P. R. China.
authors.forename: Jiaan
authors.initials: J
authors.lastname: Shao
authors.forename: Wenteng
authors.initials: W
authors.lastname: Chen
authors.forename: Marc A
authors.initials: MA
authors.lastname: Giulianotti
authors.forename: Richard A
authors.initials: RA
authors.lastname: Houghten
authors.forename: Yongping
authors.initials: Y
authors.lastname: Yu
mesh_terms: D000179:Acrylates / Q000737:chemistry; D000475:Alkenes / Q000737:chemistry*; D002384:Catalysis; D006146:Guanidines / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D010165:Palladium / Q000737:chemistry*
chemical_list: D000179:Acrylates; D000475:Alkenes; D006146:Guanidines; D010165:Palladium; C040833:ethyl acrylate