title: Crystal storing histiocytosis: a rare presentation of plasma cell myeloma.
abstract: Crystal storing histiocytosis (CSH) is a very rare association with plasma cell dyscrasias. It is presumed to be an intra-lysosomal accumulation of the secreted paraprotein aggregated into crystals and is associated with presence of variable numbers of histiocyte-like cells with phagocytosed crystalline inclusions in the bone marrow and other extramedullary sites Herein we report a case of multiple myeloma associated with CSH with a rapidly downhill clinical course. There was diagnostic confusion at the outset with a histiocytic disorder which was clarified with the use of Immunohistiochemistry along with serum protein electrophoresis and immunofixation.
authors.affiliation: Department of Hematology, All India Institute of Medical Sciences, New Delhi, 110 029 India.
authors.forename: Rakhee
authors.initials: R
authors.lastname: Kar
authors.forename: Shyamali
authors.initials: S
authors.lastname: Dutta
authors.forename: Rahul
authors.initials: R
authors.lastname: Bhargava
authors.forename: Seema
authors.initials: S
authors.lastname: Tyagi
keywords: Crystal storing histiocytosis; Immunohistiochemistry; Plasma cell dyscrasias