title: Awareness of endometrial cancer risk and compliance with screening in hereditary nonpolyposis colorectal cancer.
abstract: OBJECTIVE
  Women with hereditary nonpolyposis colorectal cancer (HNPCC) have a 40-60% lifetime risk for endometrial cancer. Guidelines in Denmark recommend gynecologic screening for female members of families with HNPCC. We estimated the knowledge of endometrial cancer risk and identified possible predictors of compliance with the screening among women from families with HNPCC.
  
  
  METHODS
  A questionnaire exploring the knowledge of endometrial cancer risk and compliance with screening was sent to 707 women from families with HNPCC who had been recommended endometrial cancer surveillance. The response rate after one reminder was 86% (606 of 707). Data were analyzed by simple and multivariable logistic regression models.
  
  
  RESULTS
  Four hundred seventy-one women were included in the final analyses; 65% reported being aware of the increased risk of endometrial cancer. The awareness was significantly greater among women with high educational level (81%; P<.001), women who had received genetic counseling (75%; P<.001), women with family history of gynecologic cancer (76%; P<.001), and those with high perceived endometrial cancer risk (77%; P<.001). Overall, 67% had participated in gynecologic screening. No significant differences were found in compliance regarding women's educational level or their family risk classification. Analyses of data in a multivariable logistic regression model showed that knowledge of endometrial cancer risk was the most important predictor for positive compliance with the gynecologic screening (odds ratio 4.86, 95% confidence interval 3.05-7.74).
  
  
  CONCLUSIONS
  Women's awareness of endometrial cancer risk is the most important predictor of their compliance with gynecologic screening in families with HNPCC.
  
  
  METHODS
  II.
authors.affiliation: The Danish HNPCC-register, Department of Surgical Gastroenterology, Copenhagen University Hospital, Hvidovre, Denmark. ketabi@dadlnet.dk
authors.forename: Zohreh
authors.initials: Z
authors.lastname: Ketabi
authors.forename: Berit J
authors.initials: BJ
authors.lastname: Mosgaard
authors.forename: Anne-Marie
authors.initials: AM
authors.lastname: Gerdes
authors.forename: Steen
authors.initials: S
authors.lastname: Ladelund
authors.forename: Inge T
authors.initials: IT
authors.lastname: Bernstein
mesh_terms: D000328:Adult; D000368:Aged; D003123:Colorectal Neoplasms, Hereditary Nonpolyposis / Q000453:epidemiology*; D055088:Early Detection of Cancer / Q000379:methods*; D016889:Endometrial Neoplasms / Q000175:diagnosis* / Q000453:epidemiology*; D005260:Female; D007722:Health Knowledge, Attitudes, Practice; D006801:Humans; D008875:Middle Aged; D010349:Patient Compliance; D012307:Risk Factors; D011795:Surveys and Questionnaires