title: Beneficial effects of tibolone on blood pressure and liver redox status in ovariectomized rats with renovascular hypertension.
abstract: Estrogen deficiency is associated with aging and increases the incidence of metabolic syndrome and hypertension. In this study, the effects of tibolone, a synthetic steroid, on the cardiovascular system, liver lipid metabolism, and redox status were evaluated, in ovariectomized (OVX) rats with renovascular hypertension (two-kidneys, one-clip, OVX + 2K1C). This study encompassed direct measurements of mean arterial pressure , plasma biochemical analysis, liver lipid contents, and assessments of the mitochondrial and peroxisomal β-oxidation capacities. Additionally, the liver redox status was assayed. Tibolone significantly reduced the mean arterial pressure of OVX + 2K1C rats, albeit reducing total and high-density lipoprotein (HDL) cholesterol levels. In the liver, although exerting an undesirable inhibition of mitochondrial and peroxisomal β-oxidation, tibolone reversed steatosis. Tibolone also improved the liver redox status: the reduced glutathione contents and the activity of glucose-6-phosphate dehydrogenase were restored by this compound, which also reduced the levels of thiobarbituric acid-reactive substances and the generation of mitochondrial reactive oxygen species. So, tibolone reversed the main alterations caused by hypertension and estrogen deficiency.
authors.affiliation: 1Department of Physiological Science, University of Maringá, Maringá, Paraná, Brazil.
authors.forename: Eduardo Hideo
authors.initials: EH
authors.lastname: Gilglioni
authors.forename: Lilian Brites
authors.initials: LB
authors.lastname: Campos
authors.forename: Monique Cristine
authors.initials: MC
authors.lastname: Oliveira
authors.forename: Rosângela Fernandes
authors.initials: RF
authors.lastname: Garcia
authors.forename: Célia Regina
authors.initials: CR
authors.lastname: Ambiel
authors.forename: Ana Julia dos Reis
authors.initials: AJ
authors.lastname: Buzzo
authors.forename: Emy Luzia
authors.initials: EL
authors.lastname: Ishii-Iwamoto
authors.forename: Clairce Luzia
authors.initials: CL
authors.lastname: Salgueiro-Pagadigorria
mesh_terms: D000818:Animals; D000959:Antihypertensive Agents / Q000494:pharmacology* / Q000627:therapeutic use*; D001794:Blood Pressure / Q000187:drug effects*; D005260:Female; D006978:Hypertension, Renovascular / Q000188:drug therapy*; D008099:Liver / Q000187:drug effects* / Q000378:metabolism*; D009652:Norpregnenes / Q000494:pharmacology* / Q000627:therapeutic use*; D010052:Ovariectomy; D010084:Oxidation-Reduction; D051381:Rats; D017208:Rats, Wistar
chemical_list: D000959:Antihypertensive Agents; D009652:Norpregnenes; C027385:tibolone