title: Complete genome sequence of Central Africa human T-cell lymphotropic virus subtype 1b.
abstract: Human T-lymphotropic virus type 1 (HTLV-1) has a global spread, and it is estimated that around 20 million persons are infected. Seven major genetic subtypes are recognized. However, there are complete genomes only from the HTLV-1a (cosmopolitan) and HTLV-1c (Melanesian) subtypes. Here, the first full-length genome of an HTLV-1b strain, a subtype so far restricted to Central African countries, is revealed. The genome size of HTLV-1b SF26, a strain isolated in Brazil, was determined to be 8,267 bp. The genomic analysis showed that all characteristic regions and genes of a prototypic HTLV-1 virus are conserved. This genome can provide information for further studies on the evolutionary history and pathogenic potential of this human oncovirus.
authors.affiliation: Laboratory of Molecular Genetics of Microorganisms, Oswaldo Cruz Institute (IOC), Oswaldo Cruz Foundation (FIOCRUZ), Rio de Janeiro, Brazil.
authors.forename: Louise
authors.initials: L
authors.lastname: Zanella
authors.forename: Koko
authors.initials: K
authors.lastname: Otsuki
authors.forename: Michel Abanto
authors.initials: MA
authors.lastname: Marin
authors.forename: Izidro
authors.initials: I
authors.lastname: Bendet
authors.forename: Ana Carolina
authors.initials: AC
authors.lastname: Vicente
mesh_terms: D000350:Africa, Central; D004279:DNA, Viral; D030541:Databases, Genetic; D005814:Genes, Viral; D016679:Genome, Viral; D015368:Human T-lymphotropic virus 1 / Q000235:genetics*; D006801:Humans; D008969:Molecular Sequence Data; D016133:Polymerase Chain Reaction / Q000379:methods; D017422:Sequence Analysis, DNA
chemical_list: D004279:DNA, Viral