title: Understanding the hypoxic niche of multiple myeloma: therapeutic implications and contributions of mouse models.
abstract: Multiple myeloma (MM) is the second most common hematological malignancy and is characterized by the clonal expansion of plasma cells in the bone marrow. Recently, hypoxia has received increased interest in the context of MM, in both basic and translational research. In this review, we describe the discovery of the hypoxic niche in MM and how it can be targeted therapeutically. We also discuss mouse models that closely mimic human MM, highlighting those that allow preclinical research into new therapies that exploit the hypoxic niche in MM.
authors.affiliation: Department of Genetics and Molecular Biology, Medical School of Xi'an Jiaotong University, Xi'an, China.
authors.forename: Jinsong
authors.initials: J
authors.lastname: Hu
authors.forename: Els
authors.initials: E
authors.lastname: Van Valckenborgh
authors.forename: Eline
authors.initials: E
authors.lastname: Menu
authors.forename: Elke
authors.initials: E
authors.lastname: De Bruyne
authors.forename: Karin
authors.initials: K
authors.lastname: Vanderkerken
mesh_terms: D000818:Animals; D015687:Cell Hypoxia; D002986:Clinical Trials as Topic; D004195:Disease Models, Animal; D006801:Humans; D051793:Hypoxia-Inducible Factor 1 / Q000378:metabolism; D051379:Mice; D009101:Multiple Myeloma / Q000473:pathology* / Q000628:therapy*; D010100:Oxygen
chemical_list: D051793:Hypoxia-Inducible Factor 1; D010100:Oxygen