title: Effects of essential oils from herbal plants and citrus fruits on DNA polymerase inhibitory, cancer cell growth inhibitory, antiallergic, and antioxidant activities.
abstract: In this study, the biological activity of 20 essential oils (EOs) from herbal plants and citrus fruits were investigated in terms of mammalian DNA polymerase (pol) inhibitory activity, cancer cell (human colon carcinoma, HCT116) growth inhibitory activity, antiallergic activity, as anti-β-hexosaminidase release activity in rat basophilic leukemia RBL-2H3 cells treated with calcium ionophore A23187, and antioxidant activity by a lipophilic-oxygen radical absorbance capacity method. These EOs showed patterns of inhibition of pol α, a DNA replicative pol, similar to their cancer cell growth inhibitory activity, and their inhibitory activity on pol λ, a DNA repair/recombination pol, by the EOs showed correlation with anti-β-hexosaminidase release activity. Among these EOs, chamomile (Matricaria chamomilla L.) was the strongest inhibitor of pols α and λ and showed significant effects on both cancer cell growth and mast cell degranulation. On the basis of these results, chamomile EO can be recommended as a potentially useful, bioactive candidate for therapeutic applications.
authors.affiliation: Laboratory of Food and Nutritional Sciences, Faculty of Nutrition, Kobe Gakuin University, Nishi-ku, Kobe, Hyogo 651-2180, Japan.
authors.forename: Mai
authors.initials: M
authors.lastname: Mitoshi
authors.forename: Isoko
authors.initials: I
authors.lastname: Kuriyama
authors.forename: Hiroto
authors.initials: H
authors.lastname: Nakayama
authors.forename: Hironari
authors.initials: H
authors.lastname: Miyazato
authors.forename: Keiichiro
authors.initials: K
authors.lastname: Sugimoto
authors.forename: Yuko
authors.initials: Y
authors.lastname: Kobayashi
authors.forename: Tomoko
authors.initials: T
authors.lastname: Jippo
authors.forename: Kazuki
authors.initials: K
authors.lastname: Kanazawa
authors.forename: Hiromi
authors.initials: H
authors.lastname: Yoshida
authors.forename: Yoshiyuki
authors.initials: Y
authors.lastname: Mizushina
mesh_terms: D000818:Animals; D018926:Anti-Allergic Agents / Q000494:pharmacology*; D000975:Antioxidants / Q000494:pharmacology*; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects*; D002957:Citrus / Q000737:chemistry*; D004791:Enzyme Inhibitors / Q000494:pharmacology*; D005260:Female; D006801:Humans; D006967:Hypersensitivity / Q000188:drug therapy / Q000276:immunology; D051379:Mice; D008813:Mice, Inbred ICR; D019384:Nucleic Acid Synthesis Inhibitors; D009822:Oils, Volatile / Q000494:pharmacology*; D010936:Plant Extracts / Q000494:pharmacology*; D010938:Plant Oils / Q000494:pharmacology*; D010946:Plants, Medicinal / Q000737:chemistry*; D051381:Rats
chemical_list: D018926:Anti-Allergic Agents; D000975:Antioxidants; D004791:Enzyme Inhibitors; D019384:Nucleic Acid Synthesis Inhibitors; D009822:Oils, Volatile; D010936:Plant Extracts; D010938:Plant Oils