title: Clinical and metabolic features of polycystic ovary syndrome among Chinese adolescents.
abstract: OBJECTIVE
  To explore the clinical and metabolic features exhibited by Chinese adolescents with polycystic ovary syndrome (PCOS) and to determine the differences between nonobese and obese adolescent patients with PCOS.
  
  
  METHODS
  Clinical cross-sectional study.
  
  
  METHODS
  Department of Gynecology and Reproductive Center.
  
  
  METHODS
  25 obese and 66 nonobese adolescents with PCOS and 26 age-matched controls.
  
  
  METHODS
  Fasting venous blood samples and an oral glucose tolerance test using 75 g of glucose were obtained from PCOS patients and controls.
  
  
  METHODS
  Clinical features were summarized. Serum levels of FSH, LH, E(2), TT, SHBG, fasting insulin, and fasting glucose were measured.
  
  
  RESULTS
  The prevalence of obesity in adolescents with PCOS was 27% (25/91). 99% of these patients presented with menstrual disorders, 84% presented with clinical and/or biochemical hyperandrogenism, and 90% exhibited an ultrasonographic appearance of polycystic ovaries. The prevalence of hirsutism and acanthosis nigricans were higher in the obese PCOS group than in the nonobese PCOS group (72% vs 41% and 44% vs 5%, respectively). A total of 5 of 20 obese (25%) and 5 of 36 nonobese patients (14%) demonstrated impaired glucose tolerance levels.
  
  
  CONCLUSIONS
  Chinese adolescents with PCOS manifest clinical and metabolic features similar to those of adult Chinese women with PCOS except for the increased prevalence of hyperandrogenism and insulin resistance. Adolescents with high risk factors, especially those with menstrual disorders and hyperandrogenism, may need careful clinical screening.
authors.affiliation: Department of Obstetrics and Gynecology, Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University, Guangzhou, China.
authors.forename: Lin
authors.initials: L
authors.lastname: Li
authors.forename: Xiaoli
authors.initials: X
authors.lastname: Chen
authors.forename: Zuanyu
authors.initials: Z
authors.lastname: He
authors.forename: Xiaomiao
authors.initials: X
authors.lastname: Zhao
authors.forename: Lili
authors.initials: L
authors.lastname: Huang
authors.forename: Dongzi
authors.initials: D
authors.lastname: Yang
mesh_terms: D000052:Acanthosis Nigricans / Q000150:complications; D000152:Acne Vulgaris / Q000150:complications; D000293:Adolescent; D000328:Adult; D001786:Blood Glucose; D015992:Body Mass Index; D016022:Case-Control Studies; D002681:China; D004958:Estradiol / Q000097:blood; D005260:Female; D005640:Follicle Stimulating Hormone / Q000097:blood; D005951:Glucose Tolerance Test; D006628:Hirsutism / Q000150:complications; D006801:Humans; D017588:Hyperandrogenism / Q000150:complications; D007328:Insulin / Q000097:blood; D007333:Insulin Resistance; D016015:Logistic Models; D007986:Luteinizing Hormone / Q000097:blood; D008599:Menstruation Disturbances / Q000150:complications; D009765:Obesity / Q000097:blood* / Q000150:complications / Q000000981:diagnostic imaging; D016017:Odds Ratio; D011085:Polycystic Ovary Syndrome / Q000097:blood* / Q000150:complications / Q000000981:diagnostic imaging; D012738:Sex Hormone-Binding Globulin / Q000378:metabolism; D013739:Testosterone / Q000097:blood; D014463:Ultrasonography; D055815:Young Adult
chemical_list: D001786:Blood Glucose; D007328:Insulin; D012738:Sex Hormone-Binding Globulin; D013739:Testosterone; D004958:Estradiol; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone