title: Peptidases trimming MHC class I ligands.
abstract: Peptides presented by MHC class I molecules are typically produced through antigen degradation by the proteasome followed by trimming by exopeptidases. According to recent results, these include both aminopeptidases and carboxypeptidases in the cytosol and the endoplasmic reticulum. While cytosolic peptidases have a net neutral or destructive effect on MHC ligands, endoplasmic reticulum aminopeptidases are required for efficient class I loading and have a strong effect on the repertoire of peptide/MHC complexes. Cells lacking these enzymes can be eliminated both by NK cells and by CD8+ T cells recognizing complexes formed between an MHC class Ib molecule and a conserved peptide. Cross-presented peptides derived from internalized antigens can be processed by insulin-regulated aminopeptidase, the only endosomal trimming peptidase.
authors.affiliation: Institut National de la Santé et de Recherche Médicale, Unité 1013, Hôpital Necker, 149 rue de Sèvres, 75015 Paris, France.
authors.forename: Mirjana
authors.initials: M
authors.lastname: Weimershaus
authors.forename: Irini
authors.initials: I
authors.lastname: Evnouchidou
authors.forename: Loredana
authors.initials: L
authors.lastname: Saveanu
authors.forename: Peter
authors.initials: P
authors.lastname: van Endert
mesh_terms: D000626:Aminopeptidases / Q000235:genetics / Q000276:immunology*; D000818:Animals; D002268:Carboxypeptidases / Q000235:genetics / Q000276:immunology*; D045142:Cross-Priming; D003602:Cytotoxicity, Immunologic / Q000235:genetics; D004721:Endoplasmic Reticulum / Q000276:immunology*; D015395:Histocompatibility Antigens Class I / Q000276:immunology*; D006801:Humans; D007694:Killer Cells, Natural / Q000276:immunology; D008024:Ligands; D015778:Minor Histocompatibility Antigens; D010446:Peptide Fragments / Q000276:immunology / Q000378:metabolism; D046988:Proteasome Endopeptidase Complex / Q000276:immunology*; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology
chemical_list: D015395:Histocompatibility Antigens Class I; D008024:Ligands; D015778:Minor Histocompatibility Antigens; D010446:Peptide Fragments; D002268:Carboxypeptidases; D000626:Aminopeptidases; C464841:ERAP1 protein, human; D046988:Proteasome Endopeptidase Complex