title: An exploratory analysis of dynamic change of metabolic syndrome in relation to the risk of developing cardiovascular disease in a chinese cohort.
abstract: BACKGROUND
  Metabolic syndrome (MS) is the syndrome closely related to cardiovascular disease (CVD) risk factors. Few prospective studies have compared the impact of dynamic changes of MS on the development of cardiovascular diseases (CVD).
  
  
  METHODS
  Overall, 3461 subjects were recruited from a cohort study on Prevention of Multiple Metabolic disorders and MS in Jiangsu of China (PMMJS) with a follow up of 3.8 years. The associations between the dynamic changes (Difference, the value at first follow-up subtract the value at baseline) of MS, component numbers, components and relative risk (RR) of CVD were analyzed by using Cox regression model.
  
  
  RESULTS
  The total incidence standardized rate of CVD was 2.58%,and the incidence standardized rates of CVD in MS-/follow-up MS-,baseline MS-/follow-up MS+, baseline MS+/follow-up MS- and baseline MS+/follow-up groups were 2.05%,5.01%,1.65% and 4.39% separately. After adjustment confounding factors Difference in FPG, BP and TG have significantly effects on the incidence of CVD.
  
  
  CONCLUSIONS
  Difference of MS component numbers had the prediction ability of CVD, but MS groups based on baseline and first follow-up MS and/or non-MS had not. In Chinese, the dynamic change of MS component numbers was a useful predict factor for CVD.
authors.affiliation: The Center for Disease Control and Prevention of Suzhou Industry Park, SuZhou, 215021,China ;  Dept. of Epidemiology, School of Public Health, Soochow University, SuZhou, 215123, China.
authors.forename: H
authors.initials: H
authors.lastname: Zhou
authors.forename: Zr
authors.initials: Z
authors.lastname: Guo
authors.forename: Xs
authors.initials: X
authors.lastname: Hu
authors.forename: Lg
authors.initials: L
authors.lastname: Yu
authors.forename: Bh
authors.initials: B
authors.lastname: Xu
authors.forename: M
authors.initials: M
authors.lastname: Wu
authors.forename: Zy
authors.initials: Z
authors.lastname: Zhou
authors.forename: C
authors.initials: C
authors.lastname: Yang
keywords: Age; Cardiovascular disease; China; Dynamic change; Metabolic syndrome