title: Antiepidermal growth factor receptor monoclonal antibodies: applications in colorectal cancer.
abstract: Patients with metastatic colorectal cancer have a poor prognosis and present a challenge to clinicians. The role of the antiepidermal growth factor receptor (EGFR) pathway in tumorogenesis and tumor progression has been well defined. This paper will review the use of anti-EGFR monoclonal antibodies in the treatment of operable, as well as metastatic colorectal cancer both in the setting of KRAS mutation unselected patients and later in KRAS wild-type patients. Active investigations designed to further identify predictive biomarkers that may be potentially druggable are reviewed as well.
authors.affiliation: Beth Israel Medical Center, Phillips Ambulatory Care Center, Continuum Cancer Centers of New York, 10 Union Square East, Suite 4C, New York, NY, USA ; Section of Hematology/Oncology, Department of Medicine, Albert Einstein College of Medicine, Bronx, NY, USA.
authors.forename: Efat
authors.initials: E
authors.lastname: Azizi
authors.forename: Adam
authors.initials: A
authors.lastname: Kittai
authors.forename: Peter
authors.initials: P
authors.lastname: Kozuch