title: Weighted lasso with data integration.
abstract: The lasso is one of the most commonly used methods for high-dimensional regression, but can be unstable and lacks satisfactory asymptotic properties for variable selection. We propose to use weighted lasso with integrated relevant external information on the covariates to guide the selection towards more stable results. Weighting the penalties with external information gives each regression coefficient a covariate specific amount of penalization and can improve upon standard methods that do not use such information by borrowing knowledge from the external material. The method is applied to two cancer data sets, with gene expressions as covariates. We find interesting gene signatures, which we are able to validate. We discuss various ideas on how the weights should be defined and illustrate how different types of investigations can utilize our method exploiting different sources of external data. Through simulations, we show that our method outperforms the lasso and the adaptive lasso when the external information is from relevant to partly relevant, in terms of both variable selection and prediction.
authors.affiliation: University of Oslo.
authors.forename: Linn Cecilie
authors.initials: LC
authors.lastname: Bergersen
authors.forename: Ingrid K
authors.initials: IK
authors.lastname: Glad
authors.forename: Heidi
authors.initials: H
authors.lastname: Lyng
mesh_terms: D019295:Computational Biology / Q000379:methods*; D003198:Computer Simulation; D018450:Disease Progression; D018628:Gene Dosage; D015972:Gene Expression Regulation, Neoplastic; D052138:Genes, Neoplasm; D055106:Genome-Wide Association Study / Q000379:methods; D006258:Head and Neck Neoplasms / Q000235:genetics / Q000473:pathology; D006801:Humans; D011237:Predictive Value of Tests; D012044:Regression Analysis; D015203:Reproducibility of Results; D012984:Software; D018709:Statistics, Nonparametric; D016019:Survival Analysis