title: Diffuse esophageal spasm in children referred for manometry.
abstract: Diffuse esophageal spasm (DES) causes chest pain and/or dysphagia in adults. We reviewed charts of 278 subjects 0 to 18 years of age after esophageal manometry to describe the frequency and characteristics of DES in children. Patient diagnoses included normal motility (61%), nonspecific esophageal motility disorder (20%), DES (13%, n=36), and achalasia (4%). Of patients with DES, the most common chief complaint was food refusal in subjects younger than 5 years (14/24, 58%) and chest pain in subjects older than 5 years (4/12, 33%). Comorbid medical conditions, often multiple, existed in 33 subjects. DES should be considered when young children present with food refusal.
authors.affiliation: Ann and Robert H. Lurie Children's Hospital of Chicago, Chicago, IL, USA.
authors.forename: John M
authors.initials: JM
authors.lastname: Rosen
authors.forename: Teri
authors.initials: T
authors.lastname: Lavenbarg
authors.forename: Jose
authors.initials: J
authors.lastname: Cocjin
authors.forename: Paul E
authors.initials: PE
authors.lastname: Hyman
mesh_terms: D000293:Adolescent; D000367:Age Factors; D002121:Calcium Channel Blockers / Q000627:therapeutic use; D002637:Chest Pain / Q000209:etiology; D002648:Child; D002675:Child, Preschool; D015331:Cohort Studies; D015897:Comorbidity; D003680:Deglutition Disorders / Q000209:etiology; D004931:Esophageal Achalasia / Q000175:diagnosis / Q000453:epidemiology / Q000503:physiopathology; D015154:Esophageal Motility Disorders / Q000175:diagnosis / Q000453:epidemiology / Q000503:physiopathology; D015155:Esophageal Spasm, Diffuse / Q000175:diagnosis* / Q000188:drug therapy / Q000453:epidemiology / Q000503:physiopathology; D004947:Esophagus / Q000187:drug effects / Q000503:physiopathology*; D005247:Feeding Behavior; D001068:Feeding and Eating Disorders / Q000209:etiology / Q000517:prevention & control; D006801:Humans; D007223:Infant; D018730:Infant Behavior; D008365:Manometry; D009543:Nifedipine / Q000627:therapeutic use; D012189:Retrospective Studies; D014839:Vomiting / Q000209:etiology / Q000517:prevention & control
chemical_list: D002121:Calcium Channel Blockers; D009543:Nifedipine