title: Curative effect of Cynodon dactylon against STZ induced hepatic injury in diabetic rats.
abstract: The aim of the study was to ascertain the role of ethanolic extract of Cynodon dactylon against hepatic complications in streptozotocin (STZ) induced type 2 diabetic models. Effect of the pre identified most effective dose of 500 mg/kg body weight was studied on hepatic injury caused by chemically induced diabetes by 55 mg/kg body weight i.p. injection of STZ in male Wistar rats. The dose of 500mg/kg body weight given once daily for 14 days reduced the levels of serum glutamate oxaloacetate transaminase, serum glutamate pyruvate transaminase, alkaline phosphatase, creatinine and urine sugar significantly (P<0.05) with increase in total protein, haemoglobin and body weight was increased. High LD(50) validates its high margin of safety.
authors.affiliation: Department of Chemistry, Sri J.N.PG. College, Lucknow, India.
authors.forename: Santosh Kumar
authors.initials: SK
authors.lastname: Singh
authors.forename: Prashant Kumar
authors.initials: PK
authors.lastname: Rai
authors.forename: Shikha
authors.initials: S
authors.lastname: Mehta
authors.forename: Rakesh Kumar
authors.initials: RK
authors.lastname: Singh
authors.forename: Geeta
authors.initials: G
authors.lastname: Watal
keywords: Antidiabetic effect; Cynodon dactylon; Diabetes; Hepatoprotective