title: [Effect of Gorei-san with tranexamic acid for preventing recurrence of chronic subdural hematoma].
abstract: OBJECTIVE
  Chronic subdural hematoma is often seen in elderly patients. One burr hole surgery with subdural drainage has been performed and prognosis is good, but the recurrence rate is still about 10%. To prevent the recurrence, we used Kampo-medicine Gorei-san with tranexamic acid after surgery. The purpose of this study is to investigate if the recurrence is able to prevent by using these drugs.
  
  
  METHODS
  From January 2008 to December 2010, 199 consecutive cases with chronic subdural hematoma were examined at Nagatomi Neurosurgical Hospital. Patients were divided into four groups according to the administered drugs; Gorei-san, tranexamic acid, Gorei-san with tranexamic acid and no drug groups. The recurrence rate was compared between each group. The chi-square test was performed as a statistical analysis.
  
  
  RESULTS
  In all patients, the mean age was 77.7±10.5 years. There were 140 males and 59 females. Overall recurrence rate was 7.0%. Each recurrence rate was 8.3% in the Gorei-san administration group, and 10.9% in the tranexamic acid group, and 2.9% in Gorei-san with tranexamic acid group, and 5.7% in the no-drug group. There was no significant difference between the four groups in statistical analysis.
  
  
  CONCLUSIONS
  Gorei-san with the tranexamic acid administration group had the minimum recurrence. There was no significant difference but these drugs would be preventable recurrence of chronic subdural hematoma. We need to accumulate more cases as a prospective study in the future.
authors.affiliation: Department of Neurosurgery, Nagatomi Neurosurgical Hospital, Oita, Japan.
authors.forename: Yukihiro
authors.initials: Y
authors.lastname: Wakabayashi
authors.forename: Masanori
authors.initials: M
authors.lastname: Yamashita
authors.forename: Tomoshige
authors.initials: T
authors.lastname: Asano
authors.forename: Akira
authors.initials: A
authors.lastname: Yamada
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Kenai
authors.forename: Yayoi
authors.initials: Y
authors.lastname: Kondoh
authors.forename: Yuzo
authors.initials: Y
authors.lastname: Hori
authors.forename: Hirofumi
authors.initials: H
authors.lastname: Nagatomi
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D004359:Drug Therapy, Combination; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D005260:Female; D020200:Hematoma, Subdural, Chronic / Q000188:drug therapy* / Q000601:surgery; D006801:Humans; D008297:Male; D020835:Medicine, Kampo; D008875:Middle Aged; D055502:Secondary Prevention; D014148:Tranexamic Acid / Q000627:therapeutic use*; D016896:Treatment Outcome
chemical_list: D004365:Drugs, Chinese Herbal; C111129:gorei-san; D014148:Tranexamic Acid