title: [The role of imbalance of fatty acids in formation of endothelium dysfunction in women in menopause].
abstract: The article deals with the results of examination of 203 women in condition of natural (61 female patients) and surgical (142 female patients) post menopause. The rate of occurrence of impairment of functional state of endothelium made up to 67% (136 of examined female patients). The nitroxide-producing function of endothelium was decreased in all female patients, most of all in women with surgical menopause. The patients with endothelium dysfunction symptoms had a significant decrease of amount of omega-3 polyunsaturated fatty and arachidonic acids in erythrocytes' membranes and an increase of amount of gamma-linolenic and dihomo-gamma-linolenic acids. The multidirectional correlation dependences between indicators of endothelium function and amount of various fatty acids in erythrocytes' membranes was established.
authors.forename: N V
authors.initials: NV
authors.lastname: lareva
authors.forename: A V
authors.initials: AV
authors.lastname: Govorin
authors.forename: E V
authors.initials: EV
authors.lastname: Luzina
mesh_terms: D004730:Endothelium, Vascular / Q000378:metabolism*; D004910:Erythrocyte Membrane / Q000378:metabolism*; D015525:Fatty Acids, Omega-3 / Q000097:blood*; D005260:Female; D006801:Humans; D009569:Nitric Oxide / Q000097:blood; D017698:Postmenopause / Q000097:blood*
chemical_list: D015525:Fatty Acids, Omega-3; D009569:Nitric Oxide