title: Retrospective evaluation of potential causes associated with clinically relevant hyperlactatemia in dogs with lymphoma.
abstract: The aim of this study was to determine whether or not canine lymphoma could be associated with a clinically relevant type B hyperlactatemia (> 2.5 mmol/L). The medical database from the University of Montreal Veterinary Medical Teaching Hospital was searched for confirmed cases of canine lymphoma with a blood lactate measurement. Information retrieved included stage, clinical observations compatible with causes of type A and B hyperlactatemia other than cancer, hepatic involvement, and drugs administered. Twenty (40%) dogs were hyperlactatemic. Five dogs (10%) were classified as having cancer-related hyperlactatemia. Seventy-five percent of hyperlactatemic dogs had clinical evidence of type A hyperlactatemia. In addition to lymphoma, 70% of hyperlactatemic dogs had evidence of an additional cause of type B hyperlactatemia. A significant association (P = 0.01) was identified between corticosteroid administration and hyperlactatemia. Cytological, echographic, and/or biochemical tests revealed hepatic changes in all hyperlactatemic dogs. Lymphoma alone may not be sufficient to explain clinically relevant hyperlactatemia in dogs.
authors.affiliation: Department of Clinical Studies, Ontario Veterinary College, University of Guelph, Guelph, Ontario N1G 2W1. mtouret@uoguelph.ca
authors.forename: Maude
authors.initials: M
authors.lastname: Touret
authors.forename: Søren R
authors.initials: SR
authors.lastname: Boysen
authors.forename: Marie-Eve
authors.initials: ME
authors.lastname: Nadeau
mesh_terms: D000137:Acid-Base Imbalance / Q000175:diagnosis / Q000453:epidemiology / Q000209:etiology / Q000662:veterinary*; D000818:Animals; D004283:Dog Diseases / Q000097:blood* / Q000175:diagnosis; D004285:Dogs; D005260:Female; D007773:Lactates / Q000097:blood*; D008223:Lymphoma / Q000097:blood / Q000175:diagnosis / Q000662:veterinary*; D008297:Male; D009369:Neoplasms / Q000097:blood / Q000175:diagnosis / Q000662:veterinary*; D012189:Retrospective Studies
chemical_list: D007773:Lactates