title: Kawasaki disease and the pediatric gastroenterologist:  a diagnostic challenge.
abstract: OBJECTIVE
  Gastrointestinal symptoms and signs are rarely the main clinical presentation of Kawasaki disease (KD). In the present study, we report a series of patients with KD in whom a gastroenterology consult was obtained before consideration of the diagnosis of KD.
  
  
  METHODS
  We retrospectively reviewed all patients with KD admitted to Children's Hospital Colorado from January 2009 through February 2011 with prominent gastrointestinal symptoms, resulting in gastrointestinal service consultation before their diagnosis of KD.
  
  
  RESULTS
  We identified 7 of 118 (6%) patients with KD who met our criteria. All 7 patients were males, and the median age at admission was 9.7 years. All patients had abdominal pain and fever at presentation. Vomiting, diarrhea, and clinical jaundice were present in 70%, 50%, and 43% of patients, respectively. Aminotransferases and/or γ-glutamyl transpeptidase abnormalities were observed in 6 (89%) patients. All of the patients had fever and rash on admission, and 86% had nonexudative conjunctivitis and 71% had mucosal changes. Median duration of illness at gastroenterology consultation was 5 days, whereas median duration of illness at infectious disease consultation was 6 days. One patient developed coronary artery dilation and 2 patients had intravenous immunoglobulin-resistant KD.
  
  
  CONCLUSIONS
  Gastroenterologists should be aware of gastrointestinal presentations of KD. Unexplained gastrointestinal symptoms in the presence of fever, and 1 or 2 of the major clinical signs of KD, should prompt consideration of KD in the differential diagnosis.
authors.affiliation: Ain Shams University. Department of Pediatrics, University of Colorado School of Medicine and Children's Hospital, Aurora, CO 80045, USA. mohammed.eladawy@childrenscolorado.org
authors.forename: Mohammed
authors.initials: M
authors.lastname: Eladawy
authors.forename: Samuel R
authors.initials: SR
authors.lastname: Dominguez
authors.forename: Marsha S
authors.initials: MS
authors.lastname: Anderson
authors.forename: Mary P
authors.initials: MP
authors.lastname: Glodé
mesh_terms: D015746:Abdominal Pain / Q000209:etiology; D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D003120:Colorado; D003937:Diagnosis, Differential; D005076:Exanthema / Q000209:etiology; D005334:Fever / Q000209:etiology; D005759:Gastroenteritis / Q000209:etiology*; D006776:Hospitals, Pediatric; D006801:Humans; D008297:Male; D008499:Medical Records; D009080:Mucocutaneous Lymph Node Syndrome / Q000175:diagnosis* / Q000503:physiopathology; D012017:Referral and Consultation; D012189:Retrospective Studies