title: Role of gold nanoparticles capping density on stability and surface reactivity to design drug delivery platforms.
abstract: Five-nanometer sized gold nanoparticles (Au NPs) stabilized with citrate ions have been reacted with various amounts of dihydrolipoic acid (DHLA) (×28, ×56, ×140, ×222, relative to Au NPs). Ligand exchange between citrate and the dithiol resulted in DHLA-capped Au NPs, whose degree of inertia was found to be related to the density of capping. The results revealed the importance of DHLA coating density to enhance the colloidal stability and modulate the reactivity toward free radicals and proteins of biological relevance. Thus, Au NPs capped with the highest amount of DHLA were found to be the ones that were, first, the most resistant to environmental changes, then characterized by the lowest residual catalytic reactivity of their metallic core, and finally the lowest interacting with proteins through nonspecific adsorption. The physicochemical properties conferred to Au NPs prepared with the ×222 excess should be valuable for further pharmaceutical development of nanoparticle platforms.
authors.affiliation: CITHEFOR EA 3452, Cibles Thérapeutiques, Formulation et Expertise Préclinique du Médicament, Faculty of Pharmacy, Université de Lorraine, BP 80403, 54001 Nancy Cedex, France.
authors.forename: Juliana
authors.initials: J
authors.lastname: Tournebize
authors.forename: Ariane
authors.initials: A
authors.lastname: Boudier
authors.forename: Anne
authors.initials: A
authors.lastname: Sapin-Minet
authors.forename: Philippe
authors.initials: P
authors.lastname: Maincent
authors.forename: Pierre
authors.initials: P
authors.lastname: Leroy
authors.forename: Raphaël
authors.initials: R
authors.lastname: Schneider
mesh_terms: D004058:Diffusion; D015195:Drug Design; D004355:Drug Stability; D006046:Gold / Q000737:chemistry*; D053768:Metal Nanoparticles / Q000737:chemistry*; D053769:Nanocapsules / Q000737:chemistry* / Q000648:ultrastructure*; D013499:Surface Properties; D008063:Thioctic Acid / Q000031:analogs & derivatives* / Q000737:chemistry
chemical_list: D053769:Nanocapsules; D008063:Thioctic Acid; D006046:Gold; C015144:dihydrolipoic acid