title: Discussion: 'Topiramate in pregnancy and risk of oral clefts,' by Margulis et al.
abstract: In the roundtable that follows, clinicians discuss a study published in this issue of the Journal in light of its methodology, relevance to practice, and implications for future research. Article discussed: Margulis AV, Mitchell AA, Gilboa SM, et al; National Birth Defects Prevention Study. Use of topiramate in pregnancy and risk of oral clefts. Am J Obstet Gynecol 2012;207:405.e1-7.
authors.affiliation: Mitchell and Elaine Yanow Professor and Head, Department of Obstetrics and Gynecology, Washington University in St. Louis, St. Louis, MO, USA.
authors.forename: George A
authors.initials: GA
authors.lastname: Macones
authors.forename: Alison
authors.initials: A
authors.lastname: Cahill
authors.forename: David M
authors.initials: DM
authors.lastname: Stamilio
authors.forename: Anthony
authors.initials: A
authors.lastname: Odibo
mesh_terms: D005260:Female; D006801:Humans; D011247:Pregnancy; D000927:Anticonvulsants / Q000009:adverse effects; D002971:Cleft Lip / Q000139:chemically induced; D002972:Cleft Palate / Q000139:chemically induced; D005632:Fructose / Q000009:adverse effects / Q000031:analogs & derivatives; D011297:Prenatal Exposure Delayed Effects / Q000453:epidemiology; D000077236:Topiramate
chemical_list: D000927:Anticonvulsants; D005632:Fructose; D000077236:Topiramate