title: [Role of shedding in the activity of immunocompetent cells with reagin protection mechanism].
abstract: In work the data on studying of a parity of the maintenance of the soluble and membrane form of antigen CD23 at almost healthy faces is cited. To the specified sign 3 groups are allocated: in parallel low maintenance membrane and free CD23 (1 group), simultaneous increase of their concentration (2 group) and increase CD23 against significant decrease in concentration sCD23 (3 group). The conclusion becomes that photolytic shedding CD23 is made by the activated cells at increase in the maintenance of phenotypes of lymphocytes CD23+. Increase of expression CD23 by lymphocytes is associated with concentration increase of cytokines IL-6 and IFN-gamma, and a natural mitogen an alpha-fetoprotein. Abscission of cells CD23 and increase of concentration sCD23 occurs at excessive increase in maintenance IgE and anti-inflammatory ofcytokine IL-10. The parity of membrane and free forms CD23 is defined by activity of an expression, shedding and an educational level association.
authors.forename: A V
authors.initials: AV
authors.lastname: Samodova
authors.forename: L K
authors.initials: LK
authors.lastname: Dobrodeeva
mesh_terms: D000818:Animals; D006801:Humans; D007371:Interferon-gamma / Q000276:immunology; D016753:Interleukin-10 / Q000276:immunology; D015850:Interleukin-6 / Q000276:immunology; D008213:Lymphocyte Activation / Q000276:immunology*; D008214:Lymphocytes / Q000276:immunology*; D011935:Reagins / Q000276:immunology*; D017455:Receptors, IgE / Q000276:immunology*; D012995:Solubility; D000509:alpha-Fetoproteins / Q000276:immunology
chemical_list: C508609:IL10 protein, human; C508600:IL6 protein, human; D015850:Interleukin-6; D011935:Reagins; D017455:Receptors, IgE; D000509:alpha-Fetoproteins; D016753:Interleukin-10; D007371:Interferon-gamma