title: Endotoxemia after high cutoff hemodialysis for treatment of patient with multiple myeloma can be prevented by using ultrapure dialysate: a case report.
abstract: To report endotoxemia presented in a case with multiple myeloma (MM) treated by high cutoff hemodialysis (HCO-HD) being prevented by using ultrapure dialysate. A female inpatient with MM received six times HCO-HD (HCO 2100 dialyzer) within 3 weeks after initiation of a chemotherapy based on vincristine+epirubicin+dexamethasone protocol. Conventional dialysate was used in the first three times and then changed to ultrapure dialysate due to elevation of body temperature after HCO-HD. Free light chains (FLC) and endotoxin levels in blood and dialysate were monitored. After six times HCO-HD, her serum FLC λ decreased from 4689 mg/L to 492.7 mg/L, with a trend of decline of serum creatinine. The clearance, reduction ratio, and removal amount of FLC λ was 38.4 mL/min, 71.0-85.2%, and 9.06-18.02 g, respectively, in the setting of dialysate flow rate 500 mL/min, while in the setting of dialysate flow rate 200 mL/min, the removal efficacy of FLC λ was lower than the former. A rise of body temperature up to 38.5°C after treatment and endotoxemia (endotoxin levels 0.122 EU/mL) was found when using conventional dialysate (endotoxin levels 0.112-0.145 EU/mL), but not seen after changing to ultrapure dialysate. Combined with appropriate chemotherapy, HCO-HD can effectively remove and reduce blood FLC. Attention should be paid to the endotoxemia and the rise of temperature after treatment when conventional dialysate is used, which can be prevented by using ultrapure dialysate.
authors.affiliation: Research Institute of Nephrology, Jinling Hospital, Nanjing University School of Medicine, Nanjing, China.
authors.forename: Dehua
authors.initials: D
authors.lastname: Gong
authors.forename: Daxi
authors.initials: D
authors.lastname: Ji
authors.forename: Kaiyue
authors.initials: K
authors.lastname: Zhang
authors.forename: Xianghua
authors.initials: X
authors.lastname: Huang
authors.forename: Gaoyuan
authors.initials: G
authors.lastname: Huang
authors.forename: Bin
authors.initials: B
authors.lastname: Xu
authors.forename: Zhihong
authors.initials: Z
authors.lastname: Liu
mesh_terms: D015314:Dialysis Solutions / Q000592:standards*; D019446:Endotoxemia / Q000209:etiology*; D005260:Female; D006801:Humans; D008875:Middle Aged; D009101:Multiple Myeloma / Q000097:blood / Q000150:complications* / Q000628:therapy*; D006435:Renal Dialysis / Q000009:adverse effects / Q000379:methods*
chemical_list: D015314:Dialysis Solutions
keywords: Multiple myeloma; endotoxemia; free light chain; high cutoff hemodialysis