title: Clinical performance and "ex vivo" dehydration of silicone hydrogel contact lenses with two new multipurpose solutions.
abstract: OBJECTIVE
  To compare the performance of two novel multipurpose disinfecting solutions (MPDS) in preventing silicone hydrogel contact lens dehydration, provide higher scores of subjective comfort and stable optical quality during a month of lens wear in neophyte volunteers.
  
  
  METHODS
  This is a prospective, double-blind, contralateral and randomised study involving the contra lateral use of Complete RevitaLens and Biotrue MPDS. Twenty-five neophytes wore Air Optix Aqua for 1 month. Volunteers were evaluated on day 1 and day 30 at 2 and 10h after lens insertion. Tear film stability using Tearscope Plus (Keeler, UK), whole eye aberrations for 4.5mm pupil size (IRx3, ImaginEyes, France) and subjective comfort (0-10 score) along with the dehydration values obtained with a gravimetric method were collected at each follow-up visit.
  
  
  RESULTS
  NIBUT values decreased significantly with both care systems from baseline to 10h visit on day 1 (p=0.032 and 0.016, mean difference=-6.7s and -7.0 s, for Complete Revitalens and Biotrue, respectively). Dehydration rates and ocular aberrations did not change significantly over the month of follow-up (p>0.05, ANOVA with Bonferroni post hoc corrections), nor between visits within the same day (p>0.05, paired sample T-test). End-of-day dryness sensation worsened similarly with both MPDS after 1 month (p=0.021 and 0.005, mean difference=-1.4 and -1.3, for Complete Revitalens and Biotrue, respectively).
  
  
  CONCLUSIONS
  Regardless of their different chemical compositions in terms of moisture additives both MPDS solutions evaluated performed similarly regarding objective measures of dehydration, tear stability and optical quality but presented significant differences in subjective symptoms.
authors.affiliation: Clinical and Experimental Optometry Research Lab, Center of Physics, University of Minho, Braga, Portugal. jgmeijome@fisica.uminho.pt
authors.forename: José Manuel
authors.initials: JM
authors.lastname: González-Méijome
authors.forename: Ana Carla
authors.initials: AC
authors.lastname: da Silva
authors.forename: Helena
authors.initials: H
authors.lastname: Neves
authors.forename: Daniela
authors.initials: D
authors.lastname: Lopes-Ferreira
authors.forename: António
authors.initials: A
authors.lastname: Queirós
authors.forename: Jorge
authors.initials: J
authors.lastname: Jorge
mesh_terms: D000328:Adult; D018639:Contact Lens Solutions / Q000494:pharmacology*; D003262:Contact Lenses, Extended-Wear; D003890:Desiccation / Q000379:methods*; D004311:Double-Blind Method; D015352:Dry Eye Syndromes / Q000517:prevention & control*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D020136:Hydrogel, Polyethylene Glycol Dimethacrylate / Q000737:chemistry*; D008297:Male; D017060:Patient Satisfaction; D011446:Prospective Studies; D012030:Refractive Errors / Q000628:therapy; D012826:Silicone Elastomers / Q000737:chemistry*; D013499:Surface Properties; D013666:Tears / Q000187:drug effects; D055815:Young Adult
chemical_list: D018639:Contact Lens Solutions; D012826:Silicone Elastomers; D020136:Hydrogel, Polyethylene Glycol Dimethacrylate