title: Excretion of compound M-11 and its metabolites with urine and feces in rats.
abstract: The excretion of compound M-11 and its metabolites with the urine and feces was studied in rats after intraperitoneal and oral administration in a dose of 25 mg/kg. Experiments showed that 1% metabolites were detected in excretions over 24 h irrespective of the route of administration, while the initial compound was not found even in trace amounts.
authors.affiliation: Laboratory of Pharmacokinetics, VV Zakusov Institute of Pharmacology, Russian Academy of Medical Sciences, Moscow, Russia. basdim21@gmail.com
authors.forename: D V
authors.initials: DV
authors.lastname: Bastrygin
authors.forename: A O
authors.initials: AO
authors.lastname: Viglinskaya
authors.forename: G B
authors.initials: GB
authors.lastname: Kolyvanov
authors.forename: A A
authors.initials: AA
authors.lastname: Litvin
authors.forename: P O
authors.initials: PO
authors.lastname: Bochkov
authors.forename: T Ya
authors.initials: TY
authors.lastname: Mozhaeva
authors.forename: V P
authors.initials: VP
authors.lastname: Zherdev
mesh_terms: D000284:Administration, Oral; D000818:Animals; D001562:Benzimidazoles / Q000008:administration & dosage / Q000032:analysis* / Q000378:metabolism* / Q000493:pharmacokinetics* / Q000652:urine; D001711:Biotransformation; D002851:Chromatography, High Pressure Liquid; D005243:Feces / Q000737:chemistry*; D007274:Injections, Intraperitoneal; D008297:Male; D015394:Molecular Structure; D009025:Morpholines / Q000008:administration & dosage / Q000032:analysis* / Q000378:metabolism* / Q000493:pharmacokinetics* / Q000652:urine; D051381:Rats; D053719:Tandem Mass Spectrometry; D013997:Time Factors
chemical_list: C410924:2-((2-morpholino)ethylthio)-5-ethoxybenzimidazole; C558388:2-(2-(3-hydroxymorpholin-4-yl)ethylthio)-5-ethoxybenzimidazole; D001562:Benzimidazoles; D009025:Morpholines