title: Spontaneous reduction of prolactinoma post cabergoline withdrawal.
abstract: Prolactinomas are common pituitary tumors usually highly responsive to dopamine agonists. Around 70-90% of the prolactinomas exhibit decrease in tumor size, though variably with these agents. Uncommonly, there may be little or no shrinkage in pituitary tumor. In the absence of medical therapy, pituitary apoplexy may also result in tumor shrinkage, albeit rarely. We report here a case showing only modest reduction in prolactinoma with cabergoline given for a period of one and a half years. Surprisingly, this tumor showed a 40% reduction in the tumor size 3 months after cabergoline withdrawal in the absence of clinical or radiological evidence of apoplexy.
authors.affiliation: Department of Endocrinology, Dr. Ram Manohar Lohia Hospital, New Delhi, India.
authors.forename: Sampath Kumar
authors.initials: SK
authors.lastname: Venkatesh
authors.forename: Deepak
authors.initials: D
authors.lastname: Kothari
authors.forename: Smita
authors.initials: S
authors.lastname: Manchanda
authors.forename: Anil
authors.initials: A
authors.lastname: Taneja
authors.forename: Bindu
authors.initials: B
authors.lastname: Kulshreshtha
keywords: Cabergoline withdrawal; prolactinoma; spontaneous involution