title: Investigating the binding mode of an inhibitor of the MBNL1·RNA complex in myotonic dystrophy type 1 (DM1) leads to the unexpected discovery of a DNA-selective binder.
authors.affiliation: Department of Chemistry, University of Illinois at Urbana-Champaign, 600 S. Mathews Ave., Urbana, IL 61801, USA.
authors.forename: Chun-Ho
authors.initials: CH
authors.lastname: Wong
authors.forename: Stacie L
authors.initials: SL
authors.lastname: Richardson
authors.forename: Yen-Jun
authors.initials: YJ
authors.lastname: Ho
authors.forename: Alex M H
authors.initials: AM
authors.lastname: Lucas
authors.forename: Tiziano
authors.initials: T
authors.lastname: Tuccinardi
authors.forename: Anne M
authors.initials: AM
authors.lastname: Baranger
authors.forename: Steven C
authors.initials: SC
authors.lastname: Zimmerman
mesh_terms: D001483:Base Sequence; D004247:DNA / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D055808:Drug Discovery; D015316:Genetic Therapy; D008024:Ligands; D056004:Molecular Dynamics Simulation; D009223:Myotonic Dystrophy / Q000235:genetics / Q000378:metabolism* / Q000628:therapy; D009690:Nucleic Acid Conformation; D011485:Protein Binding / Q000187:drug effects; D012313:RNA / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D016601:RNA-Binding Proteins / Q000378:metabolism*; D013379:Substrate Specificity; D018911:Trinucleotide Repeats
chemical_list: D008024:Ligands; D016601:RNA-Binding Proteins; D012313:RNA; D004247:DNA