title: Immunoglobulin E and mast cell proteases are potential risk factors of impaired fasting glucose and impaired glucose tolerance in humans.
abstract: OBJECTIVE
  Mast cells are important in experimental diabetes. Plasma levels of immunoglobulin E (IgE), tryptases, and chymases are inflammatory markers of human diabetes. Whether they also correlate with the risk of pre-diabetes, however, remains unknown.
  
  
  RESULTS
  A total of 260 subjects 55-75 years of age were grouped as normal glucose tolerance (NGT), isolated impaired fasting glucose (I-IFG), isolated impaired glucose tolerance (I-IGT), and mixed IFG/IGT. There were significant differences in plasma levels of high-sensitivity C-reactive protein (hsCRP) (P < 0.001) and IgE (P = 0.003) among all subgroups of pre-diabetes, and chymase in I-IGT (P = 0.043) and mixed IFG/IGT (P = 0.037) subgroups compared with NGT group. High-sensitivity CRP was a risk factor in all subgroups of pre-diabetes; IgE was a risk factor of mixed IFG/IGT; and chymase was a risk factor of I-IGT and mixed IFG/IGT. Interactions between hsCRP and high waist circumference (WC), waist-to-hip ratio (WHR), or HOMA-β index, and interactions between IgE and high WC or tryptase levels all increased further the risk of developing I-IFG, I-IGT, or mixed IFG/IGT.
  
  
  CONCLUSIONS
  Plasma hsCRP, IgE, and chymase levels associate with pre-diabetes status. While hsCRP, IgE, and chymase are individual risk factors of pre-diabetes, interactions with metabolic parameters increased further the risk of pre-diabetes.
authors.affiliation: Department of Clinical Medicine, School of Medicine, Huzhou Teachers College , Huzhou, 313000, Zhejiang , China.
authors.forename: Zhen
authors.initials: Z
authors.lastname: Wang
authors.forename: Hong
authors.initials: H
authors.lastname: Zhang
authors.forename: Xu-Hui
authors.initials: XH
authors.lastname: Shen
authors.forename: Kui-Li
authors.initials: KL
authors.lastname: Jin
authors.forename: Guo-Fen
authors.initials: GF
authors.lastname: Ye
authors.forename: Wei
authors.initials: W
authors.lastname: Qiu
authors.forename: Li
authors.initials: L
authors.lastname: Qian
authors.forename: Bo
authors.initials: B
authors.lastname: Li
authors.forename: Yong-Hong
authors.initials: YH
authors.lastname: Zhang
authors.forename: Guo-Ping
authors.initials: GP
authors.lastname: Shi
mesh_terms: D000368:Aged; D001786:Blood Glucose / Q000032:analysis; D002097:C-Reactive Protein / Q000032:analysis; D053818:Chymases / Q000097:blood*; D005215:Fasting; D005260:Female; D005951:Glucose Tolerance Test; D006706:Homeostasis; D006801:Humans; D006973:Hypertension / Q000453:epidemiology; D007073:Immunoglobulin E / Q000097:blood*; D050417:Insulin-Secreting Cells / Q000502:physiology; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D011236:Prediabetic State / Q000097:blood*; D012307:Risk Factors; D012737:Sex Factors; D053802:Tryptases / Q000097:blood*; D055105:Waist Circumference; D049629:Waist-Hip Ratio
chemical_list: D001786:Blood Glucose; D007073:Immunoglobulin E; D002097:C-Reactive Protein; D053818:Chymases; D053802:Tryptases