title: Differentiation of benign from malignant solid breast masses: comparison of two-dimensional and three-dimensional shear-wave elastography.
abstract: OBJECTIVE
  To prospectively compare the diagnostic performances of two-dimensional (2D) and three-dimensional (3D) shear-wave elastography (SWE) for differentiating benign from malignant breast masses.
  
  
  METHODS
  B-mode ultrasound and SWE were performed for 134 consecutive women with 144 breast masses before biopsy. Quantitative elasticity values (maximum and mean elasticity in the stiffest portion of mass, Emax and Emean; lesion-to-fat elasticity ratio, Erat) were measured with both 2D and 3D SWE. The area under the receiver operating characteristic curve (AUC), sensitivity and specificity of B-mode, 2D, 3D SWE and combined data of B-mode and SWE were compared.
  
  
  RESULTS
  Sixty-seven of the 144 breast masses (47 %) were malignant. Overall, higher elasticity values of 3D SWE than 2D SWE were noted for both benign and malignant masses. The AUC for 2D and 3D SWE were not significantly different: Emean, 0.938 vs 0.928; Emax, 0.939 vs 0.930; Erat, 0.907 vs 0.871. Either 2D or 3D SWE significantly improved the specificity of B-mode ultrasound from 29.9 % (23 of 77) up to 71.4 % (55 of 77) and 63.6 % (49 of 77) without a significant change in sensitivity.
  
  
  CONCLUSIONS
  Two-dimensional and 3D SWE performed equally in distinguishing benign from malignant masses and both techniques improved the specificity of B-mode ultrasound.
authors.affiliation: Department of Radiology, Seoul National University Hospital, 28, Yongon-dong, Chongno-gu, Seoul 100-744, Korea.
authors.forename: Su Hyun
authors.initials: SH
authors.lastname: Lee
authors.forename: Jung Min
authors.initials: JM
authors.lastname: Chang
authors.forename: Won Hwa
authors.initials: WH
authors.lastname: Kim
authors.forename: Min Sun
authors.initials: MS
authors.lastname: Bae
authors.forename: Nariya
authors.initials: N
authors.lastname: Cho
authors.forename: Ann
authors.initials: A
authors.lastname: Yi
authors.forename: Hye Ryoung
authors.initials: HR
authors.lastname: Koo
authors.forename: Seung Ja
authors.initials: SJ
authors.lastname: Kim
authors.forename: Jin You
authors.initials: JY
authors.lastname: Kim
authors.forename: Woo Kyung
authors.initials: WK
authors.lastname: Moon
mesh_terms: D000328:Adult; D000368:Aged; D001943:Breast Neoplasms / Q000000981:diagnostic imaging* / Q000453:epidemiology*; D003937:Diagnosis, Differential; D054459:Elasticity Imaging Techniques / Q000706:statistics & numerical data*; D005260:Female; D006801:Humans; D021621:Imaging, Three-Dimensional / Q000706:statistics & numerical data*; D008875:Middle Aged; D015995:Prevalence; D015203:Reproducibility of Results; D056910:Republic of Korea / Q000453:epidemiology; D012680:Sensitivity and Specificity; D016217:Ultrasonography, Mammary / Q000379:methods* / Q000706:statistics & numerical data*; D055815:Young Adult