title: Effects of chronic ethanol consumption in blood: A time dependent study on rat.
abstract: Alcohol consumption and health outcomes are complex and multidimensional. Ethanol (1.6g / kg body weight/ day) exposure initially affects liver function followed by renal function of 16-18 week-old male albino rats of Wistar strain weighing 200-220 g. Chronic ethanol ingestion increased in thiobarbituric acid reactive substances level and glutathione s-transferase activity; while decreased reduced gluatathione content and activities of catalase, glutathione peroxidase and glutathione reductase in a time dependent manner in the hemolysate. Though superoxide dismutase activity increased initially might be due to adaptive response, but decreased later. Elevation of serum nitrite level and transforming growth factor-b(1) activity indicated that long-term ethanol consumption may cause hepatic fibrosis and can elicit pro-angiogenic factors. However, no alteration in vascular endothelial growth factor-C activity indicated that ethanol consumption is not associated with lymphangiogenesis. Therefore, we conclude that long-term ethanol-induced toxicity is linked to an oxidative stress, which may aggravate to fibrosis and elevate pro-angiogenic factors, but not associated with lymphangiogenesis.
authors.affiliation: Department of Biochemistry, Amrita Institute of Medical Sciences, Elamakkara, Cochin, 682026 Kerala India  ; Department of Biochemistry, Agartala Govt. Medical College, Kunjaban PO, Agartala, 799006 Tripura India.
authors.forename: Subir Kumar
authors.initials: SK
authors.lastname: Das
authors.forename: L
authors.initials: L
authors.lastname: Dhanya
authors.forename: Sowmya
authors.initials: S
authors.lastname: Varadhan
authors.forename: Sukhes
authors.initials: S
authors.lastname: Mukherjee
authors.forename: D M
authors.initials: DM
authors.lastname: Vasudevan
keywords: Ethanol; Glutathione; Liver function; Nitric oxide; Oxidative stress; Transforming growth factor; Vascular endothelial growth factor