title: Diversity and composition of dengue virus type 2 in Venezuela.
abstract: Dengue is a mosquito-borne disease caused by four closely related dengue virus (genus Flavivirus)serotypes (DENV-1–4). The clinical outcomes vary from mild febrile illness to life-threatening haemorrhagic manifestations. DENVs are endemic in the tropics and subtropics globally and currently no specific treatment or vaccines are available. In Venezuela, the American-Asian genotype of DENV-2 is the most prevalent and has been associated with severe disease outcomes.We aimed to follow-up the molecular epidemiology of DENV-2 in Venezuela to investigate if the evolution of the virus has remained the same throughout time or if the same dynamics documented in Brazil (hyperendemic co-circulation) also occurred. The results show that whereas the epidemiology of DENV in several endemic areas is characterized by serotype replacements through time, in Venezuela the American-Asian genotype DENV-2 has evolved into several genetic lineages and has remained in hyperendemic co-circulation with the other serotypes.
authors.affiliation: Research Programs Unit, Infection Biology & Department of Virology, Haartman Institute, University of Helsinki, Finland.
authors.forename: E
authors.initials: E
authors.lastname: Huhtamo
authors.forename: G
authors.initials: G
authors.lastname: Comach
authors.forename: G
authors.initials: G
authors.lastname: Sierra
authors.forename: D E
authors.initials: DE
authors.lastname: Camacho
authors.forename: T
authors.initials: T
authors.lastname: Sironen
authors.forename: O
authors.initials: O
authors.lastname: Vapalahti
authors.forename: N Y
authors.initials: NY
authors.lastname: Uzcátegui
mesh_terms: D000293:Adolescent; D000328:Adult; D000369:Aged, 80 and over; D002648:Child; D002675:Child, Preschool; D016000:Cluster Analysis; D003715:Dengue / Q000453:epidemiology* / Q000821:virology*; D003716:Dengue Virus / Q000145:classification* / Q000235:genetics* / Q000302:isolation & purification; D005260:Female; D014644:Genetic Variation; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D017720:Molecular Epidemiology; D008969:Molecular Sequence Data; D010802:Phylogeny; D012367:RNA, Viral / Q000235:genetics; D020133:Reverse Transcriptase Polymerase Chain Reaction; D017422:Sequence Analysis, DNA; D017385:Sequence Homology; D014687:Venezuela / Q000453:epidemiology; D055815:Young Adult
chemical_list: D012367:RNA, Viral