title: Pelvic exenteration for recurrent cervical cancer: ten-year experience at National Cancer Center in Korea.
abstract: OBJECTIVE
  To evaluate survival and morbidity after pelvic exenteration (PE) for the curative management of recurrent cervical cancer.
  
  
  METHODS
  We retrospectively evaluated patients with recurrent cervical cancer who underwent PE from January 2001 to April 2011. Patients were identified from the registry of our institution. The clinical status and demographic information was obtained by reviewing the medical records.
  
  
  RESULTS
  Sixty-one recurrent cervical cancer patients underwent PE. Patients who received radiotherapy, operation, chemotherapy before PE were 98%, 41%, and 23%, respectively. The total morbidity rate was 44%; 10 (16%) patients had early complications (30 days or less after PE), whereas 22 (36%) patients had late complications. Wound problems were common early complications (7/18), and bowel fistulas were common late complications (9/30). The five-year overall survival and five-year disease-free survival were 56% and 49%, respectively. Median follow-up was 22 months (range, 1.8 to 60 months). Affecting factors for overall survival were resection margin status, pelvic wall and rectal involvement.
  
  
  CONCLUSIONS
  Our overall 5-year survival is encouraging. Although the morbidity rate is still high, PE is a potentially curative opportunity in gynecological malignancies with no other treatment options. The most important factors for overall survival after PE are the resection margin status, pelvic wall involvement and rectal involvement.
authors.affiliation: Center for Uterine Cancer, Research Institute and Hospital, National Cancer Center, Goyang, Korea.
authors.forename: Heon Jong
authors.initials: HJ
authors.lastname: Yoo
authors.forename: Myong Cheol
authors.initials: MC
authors.lastname: Lim
authors.forename: Sang-Soo
authors.initials: SS
authors.lastname: Seo
authors.forename: Sokbom
authors.initials: S
authors.lastname: Kang
authors.forename: Chong Woo
authors.initials: CW
authors.lastname: Yoo
authors.forename: Joo-Young
authors.initials: JY
authors.lastname: Kim
authors.forename: Sang-Yoon
authors.initials: SY
authors.lastname: Park
keywords: Gynecological malignancies; Pelvic exenteration; Surgical outcomes