title: Chondroitin sulfate functionalized mesostructured silica nanoparticles as biocompatible carriers for drug delivery.
abstract: Mesoporous silica nanoparticles (MSNs) have garnered a great deal of attention as potential carriers for therapeutic payloads. Here, we report a pH-responsive drug-carrier based on chondroitin sulfate functionalized mesostructured silica nanoparticles (NMChS-MSNs) ie, the amidation between NMChS macromer and amino group functionalized MSNs. The prepared nanoparticles were characterized using dynamic light scattering, fourier transform infrared spectroscopy and transmission electron microscopy. The resultant NMChS-MSNs were uniform spherical nanoparticles with a mean diameter of approximately 74 nm. Due to the covalent graft of hydrophilic and pH responsive NMChS, the NMChS-MSNs could be well dispersed in aqueous solution, which is favorable to being utilized as drug carriers to construct a pH-responsive controlled drug delivery system. Doxorubicin hydrochloride (DOX), a well-known anticancer drug, could be effectively loaded into the channels of NMChS-MSNs through electrostatic interactions between drug and matrix. The drug release rate of DOX@NMChS-MSNs was pH dependent and increased with the decrease of pH. The in vitro cytotoxicity test indicated that NMChS-MSNs were highly biocompatible and suitable to use as drug carriers. Our results imply that chondroitin sulfate functionalized nanoparticles are promising platforms to construct the pH-responsive controlled drug delivery systems for cancer therapy.
authors.affiliation: Department of Pharmacology, Yangzhou University Medical Academy, Yangzhou, People's Republic of China.
authors.forename: Juqun
authors.initials: J
authors.lastname: Xi
authors.forename: Jin
authors.initials: J
authors.lastname: Qin
authors.forename: Lei
authors.initials: L
authors.lastname: Fan
mesh_terms: D001672:Biocompatible Materials / Q000138:chemical synthesis*; D002809:Chondroitin Sulfates / Q000737:chemistry*; D003460:Crystallization / Q000379:methods; D004058:Diffusion; D008422:Materials Testing; D053769:Nanocapsules / Q000737:chemistry* / Q000648:ultrastructure; D010316:Particle Size; D012822:Silicon Dioxide / Q000737:chemistry*
chemical_list: D001672:Biocompatible Materials; D053769:Nanocapsules; D012822:Silicon Dioxide; D002809:Chondroitin Sulfates
keywords: chondroitin sulfate; drug delivery; mesoporous silica nanoparticle; pH sensitive