title: No implication of thromboxane prostanoid receptors in reactive hyperemia of skin and skeletal muscle in human forearm.
abstract: There is evidence that reactive hyperemia (ie, the transient increase of blood flow above resting level after a short period of ischemia) could be negatively modulated by vasoconstrictor prostanoids. The present study tested whether pharmacological blockade of the thromboxane prostanoid receptors with the specific antagonist S18886 (terutroban) would amplify reactive hyperemia in human skin and skeletal muscle. Twenty healthy young male volunteers were enrolled in a randomized, blinded, crossover trial of oral S18886 30 mg/d for 5 days versus placebo. Reactive hyperemia was evaluated in forearm skin and skeletal muscle, after occlusion of the brachial artery with a pneumatic cuff inflated at suprasystolic pressure. Blood flow was measured with laser Doppler imaging (skin) and strain gauge venous occlusion plethysmography (muscle). On the first and last day of each treatment period, recordings of reactive hyperemia were obtained immediately before and 2 hours after drug intake. Whether in forearm muscle or skin, S18886 had no discernible effect on peak postocclusion blood flow, nor on the global hyperemic response as quantified by the area under curve. These results do not support that thromboxane prostanoid receptor activation could exert a moderating influence on reactive hyperemia in human skin and skeletal muscle, at least in young subjects.
authors.affiliation: Division de Physiopathologie clinique, Centre Hospitalier Universitaire Vaudois and Université de Lausanne, Lausanne, Switzerland.
authors.forename: Antoine
authors.initials: A
authors.lastname: Pasche
authors.forename: Abigael
authors.initials: A
authors.lastname: Heim
authors.forename: Lucas
authors.initials: L
authors.lastname: Liaudet
authors.forename: Bernard
authors.initials: B
authors.lastname: Waeber
authors.forename: François
authors.initials: F
authors.lastname: Feihl
mesh_terms: D000293:Adolescent; D000328:Adult; D018592:Cross-Over Studies; D004311:Double-Blind Method; D005542:Forearm / Q000098:blood supply; D006801:Humans; D006940:Hyperemia / Q000209:etiology*; D017078:Laser-Doppler Flowmetry; D008297:Male; D018482:Muscle, Skeletal / Q000098:blood supply / Q000187:drug effects*; D009281:Naphthalenes / Q000494:pharmacology*; D010991:Plethysmography; D011422:Propionates / Q000494:pharmacology*; D044244:Receptors, Thromboxane A2, Prostaglandin H2 / Q000037:antagonists & inhibitors / Q000378:metabolism*; D012867:Skin / Q000098:blood supply / Q000187:drug effects*; D055815:Young Adult
chemical_list: D009281:Naphthalenes; D011422:Propionates; D044244:Receptors, Thromboxane A2, Prostaglandin H2; C501362:terutroban