title: [The transrectal ultrasonography of prostate in men with congenital hypogonadism treated by long term testosterone replacement therapy].
abstract: BACKGROUND
  The aim of the study was to evaluate prostate transrectal ultrasonography findings in men with congenital hypogonadism treated by long term testosterone replacement therapy.
  
  
  METHODS
  We have gradually included 31 men with congenital hypogonadism in period of 2001-2011. The average follow-up was 7.3 years (2 months - 10.8 years). We have used Sustanon® 250 i.m. every 3 weeks or Nebido® i.m. every 3 months for continual testosterone replacement therapy. We performed to all patients the transrectal ultrasonography of prostate and seminal vesicles by biplanar rectal probe every 6 months.
  
  
  RESULTS
  During the transrectal ultrasonography we observed in 22 (71.0 %) patients changes in prostatic tissue. In case of 12 patients were diagnosed asymptomatic prostatic cysts, in 9 patients prostatolithiasis and in 5 patients changes in echogenity of prostatic tissue. In 2 patients was found simultaneous occurrence of prostatic cyst and prostolithiasis, in further 2 patients simultaneous occurrence of hyperechogenic prostatic lesion and prostatolithiasis. The above described findings were diagnosed in 5 patients in the treatment lasting from 3 to 5 years, for the other 17 men with hormone replacement therapy longer than 5 years.
  
  
  CONCLUSIONS
  The study presents long term results of complex treatment in patients with disorders of sexual development, onset and progress of puberty. The long term treatment of these patients in interdisciplinary cooperation of endocrinologist and andrologist may significantly contribute to clarify an impact of testosterone replacement therapy on prostate development.
authors.affiliation: Univerzita Karlova v Praze, lékařská fakulta, Urologická klinika, Praha. jiri.heracek@lf3.cuni.cz
authors.forename: Jiří
authors.initials: J
authors.lastname: Heráček
authors.forename: Karim
authors.initials: K
authors.lastname: El Balouly
authors.forename: Vladimír
authors.initials: V
authors.lastname: Sobotka
authors.forename: Marta
authors.initials: M
authors.lastname: Šnajderová
authors.forename: Božena
authors.initials: B
authors.lastname: Kalvachová
authors.forename: Michael
authors.initials: M
authors.lastname: Urban
mesh_terms: D000293:Adolescent; D000328:Adult; D020249:Hormone Replacement Therapy / Q000009:adverse effects; D006801:Humans; D007006:Hypogonadism / Q000151:congenital / Q000188:drug therapy*; D008297:Male; D011467:Prostate / Q000000981:diagnostic imaging*; D011469:Prostatic Diseases / Q000139:chemically induced / Q000000981:diagnostic imaging; D013739:Testosterone / Q000009:adverse effects / Q000627:therapeutic use*; D014463:Ultrasonography; D055815:Young Adult
chemical_list: D013739:Testosterone