title: Bactericidal strontium-releasing injectable bone cements based on bioactive glasses.
abstract: Strontium-releasing injectable bone cements may have the potential to prevent implant-related infections through the bactericidal action of strontium, while enhancing bone formation in patients suffering from osteoporosis. A melt-derived bioactive glass (BG) series (SiO2–CaO–CaF2–MgO) with 0–50% of calcium substituted with strontium on a molar base were produced. By mixing glass powder, poly(acrylic acid) and water, cements were obtained which can be delivered by injection and set in situ, giving compressive strength of up to 35 MPa. Strontium release was dependent on BG composition with increasing strontium substitution resulting in higher concentrations in the medium. Bactericidal effects were tested on Staphylococcus aureus and Streptococcus faecalis; cell counts were reduced by up to three orders of magnitude over 6 days. Results show that bactericidal action can be increased through BG strontium substitution, allowing for the design of novel antimicrobial and bone enhancing cements for use in vertebroplasty or kyphoplasty for treating osteoporosis-related vertebral compression fractures.
authors.affiliation: 1Unit of Dental Physical Sciences, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, Mile End Road, London E1 4NS, UK. delia.brauer@uni-jena.de
authors.forename: Delia S
authors.initials: DS
authors.lastname: Brauer
authors.forename: Natalia
authors.initials: N
authors.lastname: Karpukhina
authors.forename: Gopal
authors.initials: G
authors.lastname: Kedia
authors.forename: Aditya
authors.initials: A
authors.lastname: Bhat
authors.forename: Robert V
authors.initials: RV
authors.lastname: Law
authors.forename: Izabela
authors.initials: I
authors.lastname: Radecka
authors.forename: Robert G
authors.initials: RG
authors.lastname: Hill
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000494:pharmacology; D001843:Bone Cements / Q000737:chemistry / Q000494:pharmacology; D002516:Ceramics / Q000737:chemistry / Q000494:pharmacology; D003692:Delayed-Action Preparations / Q000737:chemistry / Q000494:pharmacology; D013293:Enterococcus faecalis / Q000254:growth & development*; D013211:Staphylococcus aureus / Q000254:growth & development*; D013324:Strontium / Q000737:chemistry / Q000494:pharmacology
chemical_list: D000900:Anti-Bacterial Agents; C022107:Bioglass; D001843:Bone Cements; D003692:Delayed-Action Preparations; D013324:Strontium