title: [Features of immunity in tobacco smoking among adolescents].
abstract: The work is devoted to the study of indicators of systemic and local immunity in the respiratory tract in healthy adolescent tobacco use. The aim of the work is to characterize indices of general and local immunity of the respiratory tract during smoking in healthy adolescents. The study of local immunity was performed in induced sputum with the use of 0.1% solution of dithiothreitol. The study used tests assessing immune status I and II level. Active smoking in healthy adolescents induces a local and general immunological signs of inflammation: in sputum--elevation of IL-1alpha level and number of cells with activation markers (SD45 and HLA-DR); in the peripheral blood--the rise of levels of IL-6, IL-8, TNF CD19 (+) - cells, IgE and IL-4 in combination with a reduction in the number of CCD3(+)-, CD4(+)-, CD8(-)-lymphocytes and depression of the phagocytic activity of neutrophils.
authors.forename: O V
authors.initials: OV
authors.lastname: Nikitina
authors.forename: I N
authors.initials: IN
authors.lastname: Chaĭnikova
authors.forename: M A
authors.initials: MA
authors.lastname: Skachkova
authors.forename: S V
authors.initials: SV
authors.lastname: Barsukova
mesh_terms: D000293:Adolescent; D015415:Biomarkers / Q000032:analysis; D016207:Cytokines / Q000032:analysis*; D006801:Humans; D007111:Immunity, Cellular; D007136:Immunoglobulins / Q000032:analysis*; D012016:Reference Values; D012907:Smoking / Q000009:adverse effects / Q000276:immunology*
chemical_list: D015415:Biomarkers; D016207:Cytokines; D007136:Immunoglobulins