title: Methotrexate on a 21-day cycle for low-risk gestational trophoblastic neoplasia.
abstract: OBJECTIVE
  To perform an outcome analysis of patients with low-risk gestational trophoblastic neoplasia (GTN) treated with a 5-day intramuscular methotrexate (MTX) regimen on a 21-day cycle.
  
  
  METHODS
  A retrospective review of 31 patients with low-risk GTN treated with a 5-day MTX regimen.
  
  
  RESULTS
  A total of 31 patients with low-risk GTN (WHO score < 7) received single-agent MTX at a dose of 0.4 mg/kg daily for 5 days every 21 days (mean number of cycles, 3; 83% remission). The only significant toxicity encountered was grade 2 stomatitis in 8 (26%) patients.
  
  
  CONCLUSIONS
  A 5-day MTX regimen given every 21 days is convenient, well-tolerated and effective for patients with low-risk GTN.
authors.affiliation: Department of Obstetrics, Gynecology and Reproductive Sciences, Temple University Hospital, Philadelphia, PA 19140, USA.
authors.forename: Juan
authors.initials: J
authors.lastname: Diaz
authors.forename: M Bijoy
authors.initials: MB
authors.lastname: Thomas
authors.forename: Charlotte
authors.initials: C
authors.lastname: Paz-Pabon
authors.forename: Enrique
authors.initials: E
authors.lastname: Hernandez
mesh_terms: D000293:Adolescent; D000328:Adult; D000964:Antimetabolites, Antineoplastic / Q000008:administration & dosage* / Q000009:adverse effects; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D005260:Female; D031901:Gestational Trophoblastic Disease / Q000188:drug therapy*; D006801:Humans; D007273:Injections, Intramuscular; D008727:Methotrexate / Q000008:administration & dosage* / Q000009:adverse effects; D008875:Middle Aged; D011247:Pregnancy; D012074:Remission Induction; D012189:Retrospective Studies; D013280:Stomatitis / Q000139:chemically induced; D055815:Young Adult
chemical_list: D000964:Antimetabolites, Antineoplastic; D008727:Methotrexate