title: Hyperlipidemia, increased lipid peroxidation and changes in antioxidant enzymes, Na(+)-K(+)-ATPase in erythrocytes of type 2 diabetic patients in andhra pradesh.
abstract: Plasma levels of lipids, lipoproteins and lipid peroxides and erythrocyte Na(+)-K(+) ATPase, Mg(2+)ATPase and antioxidant enzymes were measured in type-2 diabetic patients. A significant decrease in Na(+)-K(+)-ATPase activity was observed in diabetic patients which was negatively correlated with blood glucose and lipid peroxides, while the Mg(2+)-ATPase activity was increased. In the diabetic subjects the plasma concentrations of Na(+) and K(+) were increased where as erythrocyte levels of Na(+) were increased and K(+) were decreased. Hyperlipidaemia and increased levels of lipid peroxides were observed in the diabetic subjects. There was a significant increase in erythrocyte catalase activity in diabetics which positively correlated with their lipid peroxides. There was no change in GPx activities between controls and diabetics.
authors.affiliation: Department of Biochemistry, Sri Venkateswara University, 517502 Tirupati.
authors.forename: R
authors.initials: R
authors.lastname: Giri
authors.forename: M M
authors.initials: MM
authors.lastname: Kesavulu
authors.forename: B K
authors.initials: BK
authors.lastname: Rao
authors.forename: V
authors.initials: V
authors.lastname: Ramana
authors.forename: C A
authors.initials: CA
authors.lastname: Rao
keywords: Hyperlipidaemia; Lipid peroxides; NIDDM; Na+−K+ATPase; antioxidant enzymes