title: Older males beget more mutations.
abstract: Three papers characterizing human germline mutation rates bolster evidence for a relatively low rate of base substitution in modern humans and highlight a central role for paternal age in determining rates of mutation. These studies represent the advent of a transformation in our understanding of mutation rates and processes, which may ultimately have public health implications.
authors.affiliation: The Wellcome Trust Sanger Institute, Hinxton, Cambridge, UK. meh@sanger.ac.uk
authors.forename: Matthew
authors.initials: M
authors.lastname: Hurles
mesh_terms: D019143:Evolution, Molecular; D005828:Genetics, Population; D006801:Humans; D009154:Mutation; D059645:Mutation Rate