title: Serum heme oxygenase-1 as a marker of lung function decline in patients with chronic silicosis.
abstract: OBJECTIVE
  To identify predictive factors of excess decline in forced expiratory volume in one second (FEV1) in patients with chronic silicosis.
  
  
  METHODS
  Forty-six male patients enrolled in 2004 were screened and received pulmonary function tests.
  
  
  RESULTS
  Among the 33 included patients, 12 were categorized as rapid decliners (reduction in FEV1 > 60 mL/yr). The mean level of serum heme oxygenase-1 (HO-1), a marker of oxidative stress, was significantly lower in rapid decliners than in normal decliners (P = 0.002). Logistic regression analysis revealed that serum HO-1 was a factor affecting clinically important decline in FEV1 (odds ratio = 0.52; 95% confidence interval, 0.31 to 0.88) independent of the effects of age, height, weight, smoking, exposure status, and C-reactive protein.
  
  
  CONCLUSIONS
  Serum HO-1 may be a predictor of lung function decline in silicosis patients.
authors.affiliation: Department of Internal Medicine and Clinical Immunology, Yokohama City University Graduate School of Medicine, Yokohama, Japan. takashisato1220@gmail.com
authors.forename: Takashi
authors.initials: T
authors.lastname: Sato
authors.forename: Yoshiaki
authors.initials: Y
authors.lastname: Saito
authors.forename: Satoshi
authors.initials: S
authors.lastname: Inoue
authors.forename: Takeshi
authors.initials: T
authors.lastname: Shimosato
authors.forename: Shigeto
authors.initials: S
authors.lastname: Takagi
authors.forename: Takeshi
authors.initials: T
authors.lastname: Kaneko
authors.forename: Yoshiaki
authors.initials: Y
authors.lastname: Ishigatsubo
mesh_terms: D000368:Aged; D015415:Biomarkers / Q000097:blood; D002097:C-Reactive Protein / Q000378:metabolism; D016022:Case-Control Studies; D002908:Chronic Disease; D018450:Disease Progression; D005500:Follow-Up Studies; D005541:Forced Expiratory Volume; D051547:Heme Oxygenase-1 / Q000097:blood*; D006801:Humans; D016014:Linear Models; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D011379:Prognosis; D011859:Radiography; D012189:Retrospective Studies; D012680:Sensitivity and Specificity; D012829:Silicosis / Q000097:blood / Q000000981:diagnostic imaging / Q000201:enzymology / Q000503:physiopathology*; D014797:Vital Capacity
chemical_list: D015415:Biomarkers; D002097:C-Reactive Protein; D051547:Heme Oxygenase-1