title: Regulation of lifespan by chemosensory and thermosensory systems: findings in invertebrates and their implications in mammalian aging.
abstract: Many environmental factors that dynamically change in nature influence various aspects of animal physiology. Animals are equipped with sensory neuronal systems that help them properly sense and respond to environmental factors. Several studies have shown that chemosensory and thermosensory neurons affect the lifespan of invertebrate model animals, including Caenorhabditis elegans and Drosophila melanogaster. Although the mechanisms by which these sensory systems modulate lifespan are incompletely understood, hormonal signaling pathways have been implicated in sensory system-mediated lifespan regulation. In this review, we describe findings regarding how sensory nervous system components elicit physiological changes to regulate lifespan in invertebrate models, and discuss their implications in mammalian aging.
authors.affiliation: Division of Molecular and Life Science, Pohang University of Science and Technology Pohang, South Korea.
authors.forename: Dae-Eun
authors.initials: DE
authors.lastname: Jeong
authors.forename: Murat
authors.initials: M
authors.lastname: Artan
authors.forename: Keunhee
authors.initials: K
authors.lastname: Seo
authors.forename: Seung-Jae
authors.initials: SJ
authors.lastname: Lee
keywords: Caenorhabditis elegans; Drosophila melanogaster; aging; chemosensation; endocrine signaling; hibernation; sensory neuron; thermosensation