title: Neurologic and motor dysfunctions in APP transgenic mice.
abstract: The discovery of gene mutations underlying autosomal dominant Alzheimer's disease has enabled researchers to reproduce several hallmarks of this disorder in transgenic mice, notably the formation of Aβ plaques in brain and cognitive deficits. APP transgenic mutants have also been investigated with respect to survival rates, neurologic functions, and motor coordination, which are all susceptible to alteration in Alzheimer dementia. Several transgenic lines expressing human mutated or wild-type APP had higher mortality rates than non-transgenic controls with or without the presence of Aβ plaques. Mortality rates were also elevated in APP transgenic mice with vascular amyloid accumulation, thereby implicating cerebrovascular factors in the precocious death observed in all APP transgenic models. In addition, myoclonic jumping has been described in APP mutants, together with seizure activity, abnormal limb-flexion and paw-clasping reflexes, and motor coordination deficits. The neurologic signs resemble the myoclonic movements, epileptic seizures, pathological reflexes, and gait problems observed in late-stage Alzheimer's disease.
authors.affiliation: Departement de Psychologie, Universite de Rouen, Mont-Saint-Aignan, France. robert.lalonde@univ-rouen.fr
authors.forename: Robert
authors.initials: R
authors.lastname: Lalonde
authors.forename: Ken-Ichiro
authors.initials: K
authors.lastname: Fukuchi
authors.forename: Catherine
authors.initials: C
authors.lastname: Strazielle
mesh_terms: D016564:Amyloid beta-Protein Precursor / Q000235:genetics* / Q000378:metabolism; D000818:Animals; D001921:Brain / Q000378:metabolism / Q000473:pathology; D004195:Disease Models, Animal; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D006801:Humans; D051379:Mice; D008822:Mice, Transgenic; D009069:Movement Disorders / Q000235:genetics* / Q000503:physiopathology; D009154:Mutation / Q000235:genetics; D009422:Nervous System Diseases / Q000235:genetics* / Q000503:physiopathology
chemical_list: D016564:Amyloid beta-Protein Precursor