title: [Results of the French cohort of the European observational study FINDER: quality of life of patients treated with antidepressants].
abstract: OBJECTIVE
  To describe health-related quality of life (HRQoL), pain, clinical outcomes and treatment patterns in French patients with depression treated by general practitioners and psychiatrists.
  
  
  METHODS
  Factors Influencing Depression Endpoints Research (FINDER) is a European longitudinal observational, naturalistic, multicentre study to determine the HRQoL (SF-36 and EQ-5D) and to assess outcomes of depression and anxiety (Hospital Anxiety and Depression Scale [HADS]), and pain (VAS) in a population of depressed patients initiating antidepressant treatment. Clinical diagnosis of depression was based on physician's clinical judgment. Physicians decided at their own discretion and clinical practice to initiate pharmacological treatment for depression. Adult patients with a first or new episode of depression were enrolled between May 2004 and September 2005, and followed up for 6 months. Across Europe, 437 physicians observed 3468 patients.
  
  
  RESULTS
  In France, 606 patients (approximately 17% of the whole sample) were enrolled by 57 psychiatrists and 46 general practitioners. These patients were (mean ± SD) 45.6 ± 13.0 years old, 69% female and 39% having had a previous depressive episode in the last 2 years. According to the patient-rated HADS score greater or equal to 11, most patients (75%) were classified as cases of depression as well as cases of anxiety (84%); 51% of patients rated their overall pain severity (based on VAS cut-off of 30 mm) as moderate/severe, with 65% of these patients reporting no medical explanation for their pain. The majority (81%) of the patients were prescribed selective serotonin reuptake inhibitors (SSRI). During the 6-month follow-up, the majority of the patients (73%) remained on the same antidepressant at the same dose during the course of treatment. Between baseline and 6-month endpoint, French patients improved their mean scores (SD) on the SF-36 physical score by+3.5 (9.0) (P<0.001) and mental score by+20.6 (14.2) (P<0.001); on the EQ-5D Health State Index by+0.37 (0.32) (P<0.001) and the EQ-5D VAS by+32.3 (25.0) (P<0.001); on the HADS depression score by-8.1 (6.0) (P<0.001) and HADS anxiety score by-6.9 (5.0) (P<0.001). Patients with moderate/severe pain at baseline improved their overall pain on a mean VAS score by-34.1 (28.7) (P<0.001).
  
  
  CONCLUSIONS
  More than half of the French patients enrolled in the study experienced pain associated with depression. During follow-up, patients improved all of their outcome measurements (physical and mental SF-36 scores, depression and anxiety HADS scores, pain VAS, EQ-5D Health State Index and VAS) and most patients remained on the same antidepressant at the same dose.
authors.affiliation: Unité de psychiatrie, Hôtel-Dieu, 1, place du Parvis-Notre-Dame, 75181 Paris cedex 4, France. nicolas.dantchev@htd.aphp.fr
authors.forename: N
authors.initials: N
authors.lastname: Dantchev
authors.forename: S
authors.initials: S
authors.lastname: Tcherny-Lessenot
authors.forename: H
authors.initials: H
authors.lastname: Picard
authors.forename: L
authors.initials: L
authors.lastname: Baraille
authors.forename: D
authors.initials: D
authors.lastname: Quail
mesh_terms: D000328:Adult; D000928:Antidepressive Agents / Q000627:therapeutic use*; D001008:Anxiety Disorders / Q000188:drug therapy / Q000523:psychology; D015331:Cohort Studies; D003431:Cross-Cultural Comparison; D003866:Depressive Disorder / Q000188:drug therapy* / Q000523:psychology*; D004305:Dose-Response Relationship, Drug; D057915:Drug Substitution; D005260:Female; D058006:General Practice; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D010147:Pain Measurement / Q000523:psychology; D010555:Personality Inventory / Q000706:statistics & numerical data; D011570:Psychiatry; D011594:Psychometrics; D011788:Quality of Life / Q000523:psychology*; D013001:Somatoform Disorders / Q000188:drug therapy / Q000523:psychology
chemical_list: D000928:Antidepressive Agents