title: VIP in inflammatory bowel disease: state of the art.
abstract: The pathogenesis of inflammatory bowel syndrome (IBD), which includes Crohn's disease (CD) and ulcerative colitis (UC) is poorly understood. However, an inflammatory component is a common hallmark. It has been suggested that CD principally involves Th1 and/or Th17 cells, while UC is considered to be more Th2 driven. Because vasoactive intestinal peptide (VIP) has emerged in the last decade as a putative candidate for the treatment of inflammatory diseases with a Th1 component, it may as well serve as a therapeutic target in CD. In addition, experiments using mice deficient in VIP or its receptors have revealed that the endogenously-produced VIP may participate in the regulation of immunity. The aim of the present review is to summarize the quite considerable array of data which suggests that the VIP-receptor system plays a key role in modulating multiple molecular and cellular players involved in IBD.
authors.affiliation: The Semel Institute and Department of Psychiatry, The David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA. CAbad@mednet.ucla.edu
authors.forename: Catalina
authors.initials: C
authors.lastname: Abad
authors.forename: Rosa
authors.initials: R
authors.lastname: Gomariz
authors.forename: James
authors.initials: J
authors.lastname: Waschek
authors.forename: Javier
authors.initials: J
authors.lastname: Leceta
authors.forename: Carmen
authors.initials: C
authors.lastname: Martinez
authors.forename: Yasmina
authors.initials: Y
authors.lastname: Juarranz
authors.forename: Alicia
authors.initials: A
authors.lastname: Arranz
mesh_terms: D000818:Animals; D006801:Humans; D015212:Inflammatory Bowel Diseases / Q000188:drug therapy / Q000378:metabolism / Q000503:physiopathology*; D051379:Mice; D018345:Mice, Knockout; D018005:Receptors, Vasoactive Intestinal Peptide / Q000096:biosynthesis / Q000502:physiology; D051193:Toll-Like Receptors / Q000187:drug effects; D014660:Vasoactive Intestinal Peptide / Q000235:genetics / Q000502:physiology* / Q000627:therapeutic use
chemical_list: D018005:Receptors, Vasoactive Intestinal Peptide; D051193:Toll-Like Receptors; D014660:Vasoactive Intestinal Peptide