title: Clinical evaluation of WT1 mRNA expression levels in peripheral blood and bone marrow in patients with myelodysplastic syndromes.
abstract: A study to evaluate WT1 mRNA expression levels in peripheral blood (PB) and bone marrow aspirate (BM) was conducted in 172 patients, including 115 with myelodysplastic syndromes (MDS), in Japan. The level of WT1 mRNA expression was evaluated according to the French-American-British (FAB) and World Health Organization (WHO) classifications (2001, 2008) and using the International Prognostic Scoring System and the WHO Prognostic Scoring System scales. WT1 mRNA expression levels in PB and BM were well correlated (r = 0.85), and they tended to increase with disease stage progression and in those at higher risk of leukemic transformation. WT1 mRNA expression can be a useful marker for the diagnosis and risk evaluation of MDS.
authors.affiliation: Department of Hematology/Oncology, Transfusion and Hemapheresis Center, Kurashiki Central Hospital, Okayama, Japan. ueda-y@kchnet.or.jp
authors.forename: Yasunori
authors.initials: Y
authors.lastname: Ueda
authors.forename: Chisato
authors.initials: C
authors.lastname: Mizutani
authors.forename: Yasuhito
authors.initials: Y
authors.lastname: Nannya
authors.forename: Mineo
authors.initials: M
authors.lastname: Kurokawa
authors.forename: Sumiko
authors.initials: S
authors.lastname: Kobayashi
authors.forename: Jin
authors.initials: J
authors.lastname: Takeuchi
authors.forename: Hideto
authors.initials: H
authors.lastname: Tamura
authors.forename: Kiyoyuki
authors.initials: K
authors.lastname: Ogata
authors.forename: Kazuo
authors.initials: K
authors.lastname: Dan
authors.forename: Hirohiko
authors.initials: H
authors.lastname: Shibayama
authors.forename: Yuzuru
authors.initials: Y
authors.lastname: Kanakura
authors.forename: Keiko
authors.initials: K
authors.lastname: Niimi
authors.forename: Ko
authors.initials: K
authors.lastname: Sasaki
authors.forename: Masato
authors.initials: M
authors.lastname: Watanabe
authors.forename: Nobuhiko
authors.initials: N
authors.lastname: Emi
authors.forename: Masanao
authors.initials: M
authors.lastname: Teramura
authors.forename: Toshiko
authors.initials: T
authors.lastname: Motoji
authors.forename: Michiko
authors.initials: M
authors.lastname: Kida
authors.forename: Kensuke
authors.initials: K
authors.lastname: Usuki
authors.forename: Satoru
authors.initials: S
authors.lastname: Takada
authors.forename: Toru
authors.initials: T
authors.lastname: Sakura
authors.forename: Yoshikazu
authors.initials: Y
authors.lastname: Ito
authors.forename: Kazuma
authors.initials: K
authors.lastname: Ohyashiki
authors.forename: Hiroyasu
authors.initials: H
authors.lastname: Ogawa
authors.forename: Takahiro
authors.initials: T
authors.lastname: Suzuki
authors.forename: Keiya
authors.initials: K
authors.lastname: Ozawa
authors.forename: Kiyotoshi
authors.initials: K
authors.lastname: Imai
authors.forename: Masaharu
authors.initials: M
authors.lastname: Kasai
authors.forename: Tomoko
authors.initials: T
authors.lastname: Hata
authors.forename: Yasushi
authors.initials: Y
authors.lastname: Miyazaki
authors.forename: Yasuyoshi
authors.initials: Y
authors.lastname: Morita
authors.forename: Akihisa
authors.initials: A
authors.lastname: Kanamaru
authors.forename: Akira
authors.initials: A
authors.lastname: Matsuda
authors.forename: Kaoru
authors.initials: K
authors.lastname: Tohyama
authors.forename: Daisuke
authors.initials: D
authors.lastname: Koga
authors.forename: Hiroya
authors.initials: H
authors.lastname: Tamaki
authors.forename: Kinuko
authors.initials: K
authors.lastname: Mitani
authors.forename: Tomoki
authors.initials: T
authors.lastname: Naoe
authors.forename: Haruo
authors.initials: H
authors.lastname: Sugiyama
authors.forename: Fumimaro
authors.initials: F
authors.lastname: Takaku
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001854:Bone Marrow Cells / Q000378:metabolism; D018450:Disease Progression; D005260:Female; D015870:Gene Expression; D006801:Humans; D007621:Karyotyping; D007962:Leukocytes / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D009190:Myelodysplastic Syndromes / Q000175:diagnosis / Q000235:genetics* / Q000378:metabolism; D011379:Prognosis; D012333:RNA, Messenger; D025721:WT1 Proteins / Q000235:genetics* / Q000378:metabolism; D055815:Young Adult
chemical_list: D012333:RNA, Messenger; D025721:WT1 Proteins