title: Characterization of the novel HLA-DQB1*06:48 allele by group-specific sequencing.
abstract: HLA-DQB1*06:48 has single nucleotide polymorphisms within codons 70 and 62 of exon 2 (GGG>AGG and AAG>AAC) relative to HLA-DQB1*06:02:01 and HLA-DQB1*06:37. This results in amino acid differences (G>R and K>N) that will change the polarity and charge of the encoded antigen and may therefore affect its peptide repertoire.
authors.affiliation: Transplantation Laboratory, Manchester Royal Infirmary, Manchester, UK. lukedfoster@gmail.com
authors.forename: L
authors.initials: L
authors.lastname: Foster
authors.forename: D
authors.initials: D
authors.lastname: Tate
authors.forename: K
authors.initials: K
authors.lastname: Poulton
mesh_terms: D000483:Alleles; D019943:Amino Acid Substitution; D044466:Asian People; D001483:Base Sequence; D014644:Genetic Variation; D059866:HLA-DQ beta-Chains / Q000235:genetics*; D006650:Histocompatibility Testing; D006801:Humans; D008297:Male; D020641:Polymorphism, Single Nucleotide; D017422:Sequence Analysis, DNA
chemical_list: D059866:HLA-DQ beta-Chains; C069051:HLA-DQB1 antigen