title: Targeting tumor metastasis by regulating Nm23 gene expression.
abstract: The Nm23 gene is a metastatic suppressor identified in a melanoma cell line and expressed in different tumors where their levels of expression are associated with reduced or increased metastatic potential. Nm23 is one of the over 20 metastasis suppressor genes (MSGs) confirmed in vivo. It is highly conserved from yeast to human, implying a critical developmental function. Tumors with alteration of the p53 gene and reduced expression of the Nm23 gene are more prone to metastasis. Nm23-H1 has 3'-5' exonuclease activity. This review focuses on the role of Nm23 in cancer progression and also a potential novel target for cancer therapy.
authors.affiliation: Department of Biotechnology, Karunya University, Karunya Nagar, Coimbatore, Tamil Nadu, India.
authors.forename: V Vinod
authors.initials: VV
authors.lastname: Prabhu
authors.lastname: Siddikuzzaman
authors.forename: V M Berlin
authors.initials: VM
authors.lastname: Grace
authors.forename: C
authors.initials: C
authors.lastname: Guruvayoorappan
mesh_terms: D000818:Animals; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D054778:NM23 Nucleoside Diphosphate Kinases / Q000235:genetics* / Q000378:metabolism; D009362:Neoplasm Metastasis; D009369:Neoplasms / Q000235:genetics* / Q000378:metabolism / Q000473:pathology*
chemical_list: D054778:NM23 Nucleoside Diphosphate Kinases; C517938:NME1 protein, human