title: Is there a link between the structural impact of thoracic outlet and the development of central venous stenosis?
abstract: Central venous stenosis (CVS) is a serious complication for chronic hemodialysis (HD) patients. Previous reports of CVS have focused on prior central venous catheterization, because of the higher prevalence and potential for prevention of such an event. However, recent studies have demonstrated that CVS may also develop without a history of central venous catheterization. Although information about the etiological backgrounds regarding the development of CVS without previous central venous catheterization have gradually accumulated, the clinical impact of the chronic compression of the central venous system by the surrounding structures, which may likely determine the central venous susceptibility to CVS, remains poorly understood. This study proposes the hypothesis that the combination of chronic venous compression at the level of thoracic outlet characterized by the natural physique and elevated venous flow induced by the creation of vascular access should be evaluated as a potential factor for the development of CVS, since they may accelerate the development of venous stenosis, presumably through the stimulation of intimal hyperplasia, and thereby the subclavian venous susceptibility to CVS should be determined.
authors.affiliation: Division of Nephrology, Department of Internal Medicine, Jichi Medical University, 3311-1 Yakushiji, Shimotsuke-Shi, Tochigi 329-0498, Japan.
authors.forename: Atsushi
authors.initials: A
authors.lastname: Kotoda
authors.forename: Tetsu
authors.initials: T
authors.lastname: Akimoto
authors.forename: Taro
authors.initials: T
authors.lastname: Sugase
authors.forename: Hisashi
authors.initials: H
authors.lastname: Yamamoto
authors.forename: Eiji
authors.initials: E
authors.lastname: Kusano
mesh_terms: D003251:Constriction, Pathologic / Q000000981:diagnostic imaging / Q000209:etiology*; D005260:Female; D006801:Humans; D008875:Middle Aged; D013350:Subclavian Vein / Q000473:pathology*; D013901:Thoracic Outlet Syndrome / Q000150:complications*; D014057:Tomography, X-Ray Computed