title: Evaluating role of oxidative stress in determining the pathogenesis of falciparum malaria induced acute renal failure.
abstract: Serum malondialdehyde was measured in sixty-one falciparum malaria cases, which include thirty uncomplicated, and thirty-one complicated with acute renal failure. Twenty-six healthy individuals were also studied as controls. Serum malondialdehyde level was found to be significantly elevated in falciparum malaria induced acute renal failure cases when compared with uncomplicated falciparum malaria (p<0.001) and healthy controls (p<0.001). A positive correlation with the raised urea, creatinine and bilirubin levels were significant (r=0.62, p<0.025; r=0.65, p<0.05 and r=0.72, p<0.001 respectively) indicating the severity of complication with rise of lipid peroxides in falciparum malaria induced acute renal failure cases.
authors.affiliation: Department of Biochemistry, SCB Medical College Hospital, Cuttack.
authors.forename: Rachita
authors.initials: R
authors.lastname: Nanda
authors.forename: Pramila K
authors.initials: PK
authors.lastname: Mishra
authors.forename: U K
authors.initials: UK
authors.lastname: Das
authors.forename: S B
authors.initials: SB
authors.lastname: Rout
authors.forename: P C
authors.initials: PC
authors.lastname: Mohapatra
authors.forename: A
authors.initials: A
authors.lastname: Panda
keywords: Acute renal failure; Falciparum malaria; Malondialdehyde; Reactive oxygen species