title: Side-chain modifications of highly functionalized 3(2H)-furanones.
abstract: A series of 3(2H)-furanones, based on side-chain modifications of a parent 3(2H)-furanone, was synthesized in good yield. The parent compound was prepared by hydrogenolysis, and subsequent acid hydrolysis, of isoxazole derivatives. The isoxazole was prepared by a [3+2] 1,3-dipolar cycloaddition reaction between 3-butyn-2-ol and nitrile oxide.
authors.affiliation: Departamento de Química, Faculdade de Filosofia, Ciências e Letras de Ribeirão Preto, Universidade de São Paulo, Avenida dos Bandeirantes, 3900, 14040-901 Ribeirão Preto, SP, Brazil. viviani@fcfrp.usp.br
authors.forename: Viviani
authors.initials: V
authors.lastname: Nardini
authors.forename: Shirley Muniz
authors.initials: SM
authors.lastname: Machado Rodrigues
authors.forename: Maurício Gomes
authors.initials: MG
authors.lastname: Constantino
authors.forename: Gil Valdo José
authors.initials: GV
authors.lastname: da Silva
mesh_terms: D000478:Alkylation; D000480:Alkynes / Q000737:chemistry; D000440:Butanols / Q000737:chemistry; D061565:Cycloaddition Reaction; D005663:Furans / Q000138:chemical synthesis / Q000737:chemistry*; D009570:Nitriles / Q000737:chemistry
chemical_list: C540507:3-butyn-2-ol; D000480:Alkynes; D000440:Butanols; D005663:Furans; D009570:Nitriles