title: Protective effect of SnCl2 on K2Cr2O7-induced toxicity in LLC-PK1 cells.
abstract: The exposure to hexavalent chromium is often known to cause acute renal failure. It has been found that nonenzymatic antioxidants and the induction of heme oxygenase 1 have protective effects against nephrotoxicity induced by potassium dichromate in vivo. In this work, the effect of stannous chloride, an inducer of heme oxygenase 1, on potassium dichromate-induced toxicity in proximal tubular epithelial cells was studied. Hexavalent chromium levels, peroxynitrite content, reduced thiol content, heme oxygenase activity, reactive oxygen species production, and stannous chloride scavenging capacity were measured. It was found that stannous chloride protects proximal tubular epithelial cells from potassium dichromate-induced cell death. The decrease in extracellular and intracellular hexavalent chromium concentration, the induction of heme oxygenase 1, and the ability to scavenge reactive oxygen species and peroxynitrite are involved in the mechanism by which stannous chloride protects proximal tubular epithelial cells from potassium dichromate-induced toxicity.
authors.affiliation: Departamento de Farmacología, Facultad de Medicina, UNAM, Av. Universidad 3000, UNAM, México D.F. 04510, México. dianabarrera@hotmail.com
authors.forename: Diana
authors.initials: D
authors.lastname: Barrera-Oviedo
authors.forename: Miriam Gabriela
authors.initials: MG
authors.lastname: Carranza-Pérez
authors.forename: Mario T
authors.initials: MT
authors.lastname: Candelario-Mota
authors.forename: Nicandro
authors.initials: N
authors.lastname: Mendoza-Patiño
authors.forename: Perla D
authors.initials: PD
authors.lastname: Maldonado
authors.forename: José
authors.initials: J
authors.lastname: Pedraza-Chaverrí
mesh_terms: D058186:Acute Kidney Injury / Q000139:chemically induced / Q000473:pathology / Q000517:prevention & control*; D000818:Animals; D002452:Cell Count; D002478:Cells, Cultured; D004195:Disease Models, Animal; D006419:Heme Oxygenase (Decyclizing) / Q000378:metabolism; D007684:Kidney Tubules / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology; D018384:Oxidative Stress; D011192:Potassium Dichromate / Q000633:toxicity; D017382:Reactive Oxygen Species / Q000378:metabolism; D013552:Swine; D017971:Tin Compounds / Q000494:pharmacology*
chemical_list: D017382:Reactive Oxygen Species; D017971:Tin Compounds; C023599:stannous chloride; D006419:Heme Oxygenase (Decyclizing); D011192:Potassium Dichromate