title: Acute kidney injury after ingestion of rhubarb: secondary oxalate nephropathy in a patient with type 1 diabetes.
abstract: BACKGROUND
  Oxalosis is a metabolic disorder characterized by deposition of oxalate crystals in various organs including the kidney. Whereas primary forms result from genetic defects in oxalate metabolism, secondary forms of oxalosis can result from excessive intestinal oxalate absorption or increased endogenous production, e.g. after intoxication with ethylene glycol.
  
  
  METHODS
  Here, we describe a case of acute crystal-induced renal failure associated with excessive ingestion of rhubarb in a type 1 diabetic with previously normal excretory renal function. Renal biopsy revealed mild mesangial sclerosis, but prominent tubular deposition of oxalate crystals in the kidney. Oxalate serum levels were increased.
  
  
  CONCLUSIONS
  Acute secondary oxalate nephropathy due to excessive dietary intake of oxalate may lead to acute renal failure in patients with preexisting renal disease like mild diabetic nephropathy. Attention should be payed to special food behaviors when reasons for acute renal failure are explored.
authors.affiliation: Nephrologisches Zentrum, Medizinische Klinik und Poliklinik IV, Campus Innenstadt, Klinikum der Ludwig-Maximilians-Universität München, Ziemssenstr, 1, 80336, Munich, Germany. Marc.Albersmeyer@med.uni-muenchen.de
authors.forename: Marc
authors.initials: M
authors.lastname: Albersmeyer
authors.forename: Robert
authors.initials: R
authors.lastname: Hilge
authors.forename: Angelika
authors.initials: A
authors.lastname: Schröttle
authors.forename: Max
authors.initials: M
authors.lastname: Weiss
authors.forename: Thomas
authors.initials: T
authors.lastname: Sitter
authors.forename: Volker
authors.initials: V
authors.lastname: Vielhauer
mesh_terms: D058186:Acute Kidney Injury / Q000175:diagnosis* / Q000209:etiology* / Q000628:therapy; D003922:Diabetes Mellitus, Type 1 / Q000150:complications* / Q000175:diagnosis* / Q000628:therapy; D005260:Female; D006801:Humans; D008875:Middle Aged; D010070:Oxalates / Q000009:adverse effects*; D012250:Rheum / Q000009:adverse effects* / Q000737:chemistry*
chemical_list: D010070:Oxalates