title: Effect of locomotor activity on ultrastructure of cerebellar neurons, neurological disturbances, and survival of Krushinsky-Molodkina rats with hemorrhagic stroke.
abstract: We studied the effect of locomotor activity on the ultrastructure of cerebellar neurons, neurological disturbances, and survival rate in Krushinsky-Molodkina rats during the development of hemorrhagic induced by acoustic stress. In animals with high spontaneous locomotor activity, severe edema of cerebellar neurons (resulting in the destruction of surrounding structures) and swelling of the synapses (terminals of mossy fibers on granule cell dendrites) were observed. By contrast, the areas of intracerebral, subdural, and subarachnoid hemorrhages were lower in rats under conditions of forced rest.
authors.affiliation: Laboratory No. 12, A. A. Kharkevich Institute for Information Transmission Problems, Russian Academy of Sciences, Russia. nsamos@iitp.ru
authors.forename: N V
authors.initials: NV
authors.lastname: Samosudova
authors.forename: V P
authors.initials: VP
authors.lastname: Reutov
authors.forename: A L
authors.initials: AL
authors.lastname: Krushinsky
authors.forename: V S
authors.initials: VS
authors.lastname: Kuzenkov
authors.forename: E G
authors.initials: EG
authors.lastname: Sorokina
mesh_terms: D000818:Animals; D002531:Cerebellum / Q000648:ultrastructure*; D002543:Cerebral Hemorrhage / Q000209:etiology / Q000235:genetics / Q000401:mortality / Q000473:pathology*; D020022:Genetic Predisposition to Disease; D008297:Male; D009043:Motor Activity; D009474:Neurons / Q000648:ultrastructure; D009622:Noise / Q000009:adverse effects; D051381:Rats; D011919:Rats, Inbred Strains; D012146:Rest; D013016:Sound / Q000009:adverse effects; D013345:Subarachnoid Hemorrhage / Q000209:etiology / Q000235:genetics / Q000401:mortality / Q000473:pathology*; D013355:Subdural Space / Q000648:ultrastructure*; D015996:Survival Rate; D013569:Synapses / Q000648:ultrastructure