title: New bioactive alkyl sulfates from Mediterranean tunicates.
abstract: Chemical investigation of two species of marine ascidians, Aplidium elegans and Ciona edwardsii, collected in Mediterranean area, led to isolation of a series of alkyl sulfates (compounds 1-5) including three new molecules 1-3. Structures of the new metabolites have been elucidated by spectroscopic analysis. Based on previously reported cytotoxic activity of these type of molecules, compounds 1-3 have been tested for their effects on the growth of two cell lines, J774A.1 (BALB/c murine macrophages) and C6 (rat glioma) in vitro. Compounds 1 and 2 induced selective concentration-dependent mortality on J774A.1 cells.
authors.affiliation: The NeaNat Group, Dipartimento di Chimica delle Sostanze Naturali, Università degli Studi di Napoli "Federico II", Via D. Montesano 49, 80131 Napoli, Italy.
authors.forename: Concetta
authors.initials: C
authors.lastname: Imperatore
authors.forename: Anna
authors.initials: A
authors.lastname: Aiello
authors.forename: Filomena
authors.initials: F
authors.lastname: D'Aniello
authors.forename: Paolo
authors.initials: P
authors.lastname: Luciano
authors.forename: Rocco
authors.initials: R
authors.lastname: Vitalone
authors.forename: Rosaria
authors.initials: R
authors.lastname: Meli
authors.forename: Giuseppina Mattace
authors.initials: GM
authors.lastname: Raso
authors.forename: Marialuisa
authors.initials: M
authors.lastname: Menna
mesh_terms: D000818:Animals; D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects*; D008264:Macrophages / Q000187:drug effects / Q000502:physiology; D009682:Magnetic Resonance Spectroscopy; D008522:Mediterranean Sea; D051379:Mice; D008807:Mice, Inbred BALB C; D015394:Molecular Structure; D051381:Rats; D013463:Sulfuric Acid Esters / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D014561:Urochordata / Q000737:chemistry*
chemical_list: D013463:Sulfuric Acid Esters