title: Multi-organ failure due to Mycobacterium tuberculosis and Aspergillus flavus infection after allogeneic bone marrow transplantation.
abstract: Mycobacterium tuberculosis (MT) is a serious, but rare infectious complication after allogeneic bone marrow transplantation (BMT). We describe a case of fatal sepsis due to MT and Aspergillus flavus after allogeneic BMT for Aplastic Anemia. The diagnosis was made on bone marrow biopsy and asitic fluid culture. Broadspectrum antituberculous and Amphotericin B therapy was started immediately after diagnosis. The patient developed severe hypoxia and finally died of multi-organ failure. Rapid progression of mycobacterial infection as well as fungal infection should be considered in patients post BMT with unexplained fever, particularly in patients from endemic areas.
authors.affiliation: Department of Hematology, IRCH Building, All India Institute of Medical Sciences (AIIMS), New Delhi, India.
authors.forename: Tuphan Kanti
authors.initials: TK
authors.lastname: Dolai
authors.forename: R
authors.initials: R
authors.lastname: Kumar
authors.forename: R
authors.initials: R
authors.lastname: Bhargava
authors.forename: M
authors.initials: M
authors.lastname: Mahapatra
authors.forename: P
authors.initials: P
authors.lastname: Mishra
authors.forename: T
authors.initials: T
authors.lastname: Seth
authors.forename: R
authors.initials: R
authors.lastname: Kar
authors.forename: S
authors.initials: S
authors.lastname: Rathi
authors.forename: H P
authors.initials: HP
authors.lastname: Pati
authors.forename: R
authors.initials: R
authors.lastname: Saxena
authors.forename: S
authors.initials: S
authors.lastname: Tyagi
keywords: Allogenic BMT; Aspergillus flavus; Mycobacterium tuberculosis