title: RNA polymerase I termination: Where is the end?
abstract: The synthesis of ribosomal RNA (rRNA) precursor molecules by RNA polymerase I (Pol I) terminates with the dissociation of the protein-DNA-RNA ternary complex. Based on in vitro results the mechanism of Pol I termination appeared initially to be rather conserved and simple until this process was more thoroughly re-investigated in vivo. A picture emerged that Pol I termination seems to be connected to co-transcriptional processing, re-initiation of transcription and, possibly, other processes downstream of Pol I transcription units. In this article, our current understanding of the mechanism of Pol I termination and how this process might be implicated in other biological processes in yeast and mammals is summarized and discussed. This article is part of a Special Issue entitled: Transcription by Odd Pols.
authors.affiliation: Universität Regensburg, Biochemie-Zentrum Regensburg (BZR), Lehrstuhl Biochemie III, 93053 Regensburg, Germany. attila.nemeth@vkl.uni-regensburg.de
authors.forename: Attila
authors.initials: A
authors.lastname: Németh
authors.forename: Jorge
authors.initials: J
authors.lastname: Perez-Fernandez
authors.forename: Philipp
authors.initials: P
authors.lastname: Merkl
authors.forename: Stephan
authors.initials: S
authors.lastname: Hamperl
authors.forename: Jochen
authors.initials: J
authors.lastname: Gerber
authors.forename: Joachim
authors.initials: J
authors.lastname: Griesenbeck
authors.forename: Herbert
authors.initials: H
authors.lastname: Tschochner
mesh_terms: D000818:Animals; D006801:Humans; D035463:Pol1 Transcription Initiation Complex Proteins / Q000378:metabolism; D012318:RNA Polymerase I / Q000378:metabolism*; D012322:RNA Precursors / Q000096:biosynthesis / Q000235:genetics; D012335:RNA, Ribosomal / Q000096:biosynthesis / Q000235:genetics; D050801:Ternary Complex Factors / Q000378:metabolism; D061806:Transcription Termination, Genetic; D015003:Yeasts / Q000235:genetics / Q000378:metabolism
chemical_list: D035463:Pol1 Transcription Initiation Complex Proteins; D012322:RNA Precursors; D012335:RNA, Ribosomal; D050801:Ternary Complex Factors; D012318:RNA Polymerase I