title: Risk of cryptorchidism and hypospadias among boys of maternal hairdressers - a Danish population-based cohort study.
abstract: OBJECTIVE
  Pregnant hairdressers may be exposed to a mixture of chemicals in their working environment. The possible relationship between these chemical agents and male reproductive tract malformations has raised concern that the working environment of hairdressers might have adverse effects on fetal development. This study assessed the risk of cryptorchidism and hypospadias among boys of maternal hairdressers.
  
  
  METHODS
  National population-based registers were used to determine maternal occupation and identify cases of cryptorchidism and hypospadias. The cohort comprised all children born in Denmark from 1980-2007. Using Cox regression, we estimated hazard ratios (HR) with 95% confidence intervals (95% CI) for hospitalization for cryptorchidism and hypospadias from 1980-2009.
  
  
  RESULTS
  Boys of hairdressers were not at increased risk of cryptorchidism (134 cases, HR 0.91; 95% CI 0.77-1.08) or hypospadias (33 cases, HR 1.27; 95% CI 0.90-1.79) compared to children of mothers in other occupations (14 988 and 2556 cases of cryptorchidism and hypospadias, respectively). Additional analyses using children of shop assistants and receptionists as controls and restricted to (i) firstborns, (ii) cryptorchidism cases with corrective surgery, (iii) specific birth years, and (iv) women without social benefit payments in gestational weeks 8-14 produced consistent results of no increased risk.
  
  
  CONCLUSIONS
  Our nationwide cohort study shows that, despite exposure to a complex chemical milieu, hairdressers do not have an increased risk of having boys with cryptorchidism and hypospadias.
authors.affiliation: Department of Occupational and Environmental Medicine, Bispebjerg Hospital, DK-2400 Copenhagen NV, Denmark. kjoe0163@bbh.regionh.dk
authors.forename: Kristian Tore
authors.initials: KT
authors.lastname: Jørgensen
authors.forename: Morten Søndergaard
authors.initials: MS
authors.lastname: Jensen
authors.forename: Gunnar Vase
authors.initials: GV
authors.lastname: Toft
authors.forename: Ann Dyreborg
authors.initials: AD
authors.lastname: Larsen
authors.forename: Jens Peter
authors.initials: JP
authors.lastname: Bonde
authors.forename: Karin Sørig
authors.initials: KS
authors.lastname: Hougaard
mesh_terms: D000328:Adult; D001461:Barbering; D003456:Cryptorchidism / Q000453:epidemiology*; D003718:Denmark / Q000453:epidemiology; D005260:Female; D006203:Hair Preparations; D006801:Humans; D007021:Hypospadias / Q000453:epidemiology*; D008297:Male; D018811:Maternal Exposure; D016273:Occupational Exposure; D015995:Prevalence; D018570:Risk Assessment; D055815:Young Adult
chemical_list: D006203:Hair Preparations