title: Markers of systemic inflammation in delayed pressure urticaria.
abstract: BACKGROUND
  We have previously reported, increased plasma IL-6 concentration in chronic urticaria. In addition, it has been suggested that IL-6 and C-reactive protein (CRP) may be useful markers of the disease activity.
  
  
  OBJECTIVE
  The aim of this study was to evaluate whether a systemic inflammation is present in delayed pressure urticaria (DPU).
  
  
  METHODS
  Plasma IL-6 and serum CRP concentrations, biomarkers of acute phase response, were measured in DPU, and the healthy subjects matched by age, gender, and BMI using ELISA method.
  
  
  RESULTS
  DPU patients showed significantly higher plasma IL-6 and serum CRP concentrations than the healthy subjects.
  
  
  CONCLUSIONS
  Similarly to the known locally increased IL-6 activity in DPU lesions, the elevated circulating levels of IL-6 and CRP have been currently found in DPU. This indicates that the disease induces a systemic inflammatory process, termed the acute phase response.
authors.affiliation: Clinical Department of Internal Diseases, Allergology and Clinical Immunology, Medical University of Silesia, Katowice, Poland. kasperska@plusnet.pl
authors.forename: Alicja
authors.initials: A
authors.lastname: Kasperska-Zajac
authors.forename: Tatiana
authors.initials: T
authors.lastname: Jasinska
authors.forename: Alicja
authors.initials: A
authors.lastname: Grzanka
authors.forename: Agata
authors.initials: A
authors.lastname: Kowalik-Sztylc
mesh_terms: D000210:Acute-Phase Reaction / Q000097:blood*; D000328:Adult; D015415:Biomarkers / Q000097:blood*; D002097:C-Reactive Protein / Q000378:metabolism*; D016022:Case-Control Studies; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D007249:Inflammation / Q000097:blood*; D015850:Interleukin-6 / Q000097:blood*; D008297:Male; D011312:Pressure / Q000009:adverse effects; D014581:Urticaria / Q000097:blood* / Q000209:etiology
chemical_list: D015415:Biomarkers; C508600:IL6 protein, human; D015850:Interleukin-6; D002097:C-Reactive Protein