title: Vitamin E supplementation and lifespan in model organisms.
abstract: We have conducted a comprehensive literature review regarding the effect of vitamin E on lifespan in model organisms including single-cell organisms, rotifers, Caenorhabditis elegans, Drosophila melanogaster and laboratory rodents. We searched Pubmed and ISI Web of knowledge for studies up to 2011 using the terms "tocopherols", "tocotrienols", "lifespan" and "longevity" in the above mentioned model organisms. Twenty-four studies were included in the final analysis. While some studies suggest an increase in lifespan due to vitamin E, other studies did not observe any vitamin E-mediated changes in lifespan in model organisms. Furthermore there are several studies reporting a decrease in lifespan in response to vitamin E supplementation. Different outcomes between studies may be partly related to species-specific differences, differences in vitamin E concentrations and the vitamin E congeners administered. The findings of our literature review suggest that there is no consistent beneficial effect of vitamin E on lifespan in model organisms which is consistent with reports in human intervention studies.
authors.affiliation: Institute of Human Nutrition and Food Science, Christian-Albrechts-University Kiel, Germany. ernst@foodsci.uni-kiel.de
authors.forename: I M A
authors.initials: IM
authors.lastname: Ernst
authors.forename: K
authors.initials: K
authors.lastname: Pallauf
authors.forename: J K
authors.initials: JK
authors.lastname: Bendall
authors.forename: L
authors.initials: L
authors.lastname: Paulsen
authors.forename: S
authors.initials: S
authors.lastname: Nikolai
authors.forename: P
authors.initials: P
authors.lastname: Huebbe
authors.forename: T
authors.initials: T
authors.lastname: Roeder
authors.forename: G
authors.initials: G
authors.lastname: Rimbach
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000737:chemistry / Q000627:therapeutic use*; D017173:Caenorhabditis elegans; D004175:Diptera; D004330:Drosophila; D004331:Drosophila melanogaster; D006801:Humans; D008136:Longevity / Q000187:drug effects*; D051379:Mice; D009348:Nematoda; D051381:Rats; D012441:Saccharomyces cerevisiae / Q000187:drug effects; D014810:Vitamin E / Q000737:chemistry / Q000627:therapeutic use*
chemical_list: D000975:Antioxidants; D014810:Vitamin E