title: Important aspects of oral paracoccidioidomycosis--a literature review.
abstract: Paracoccidioidomycosis is a deep mycosis endemic to Latin America, with considerable morbidity and mortality. It is caused by the dimorphic fungus Paracoccidioides brasiliensis, which affects, among other organs in the human body, the oral cavity. Fungus virulence and immunocompetence of the host determine the establishment of infection or active disease, whose severity and clinical behaviour depend mostly on the cellular immune response of the host. Often, oral lesions constitute the first sign and site of confirmation of diagnosis, which in most cases is delayed. The success of the treatment depends on early and correct diagnosis, as well as on the patient's adherence to the drug therapy.
authors.affiliation: Pontifical Catholic University of Rio Grande do Sul, Porto Alegre, Brazil.
authors.forename: Mariana Àlvares de
authors.initials: MÀ
authors.lastname: Abreu e Silva
authors.forename: Fernanda Gonçalves
authors.initials: FG
authors.lastname: Salum
authors.forename: Maria Antonia
authors.initials: MA
authors.lastname: Figueiredo
authors.forename: Karen
authors.initials: K
authors.lastname: Cherubini
mesh_terms: D000935:Antifungal Agents / Q000627:therapeutic use; D000946:Antigens, Fungal / Q000097:blood; D006801:Humans; D007111:Immunity, Cellular; D007371:Interferon-gamma / Q000276:immunology; D008168:Lung / Q000276:immunology / Q000382:microbiology / Q000473:pathology; D009061:Mouth Mucosa / Q000276:immunology / Q000382:microbiology* / Q000473:pathology; D010228:Paracoccidioides / Q000276:immunology / Q000472:pathogenicity*; D010229:Paracoccidioidomycosis / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000276:immunology*; D012720:Severity of Illness Index; D012867:Skin / Q000382:microbiology / Q000473:pathology; D013997:Time Factors; D014057:Tomography, X-Ray Computed; D014774:Virulence
chemical_list: D000935:Antifungal Agents; D000946:Antigens, Fungal; D007371:Interferon-gamma