title: [Pulmonary toxicity resulting from the use of nitrofurantoin].
abstract: Acute pulmonary syndrome is an uncommon but severe adverse reaction to nitrofurantoin. This syndrome is seldom recognised at the moment of presentation, which potentially subjects patients to unnecessary treatment and delays in the discontinuation of nitrofurantoin. We discuss the case histories of an 80-year-old and an 81-year-old woman, each presenting with acute pulmonary syndrome after nitrofurantoin administration. The diagnosis of acute pulmonary syndrome should be considered in patients presenting with fever, dyspnoea, dry cough, leukocytosis (typically with eosinophilia) and a bilateral interstitial pattern visible on the chest X-ray after having started nitrofurantoin. The prognosis is excellent if the condition is recognised early and the exposure to nitrofurantoin is discontinued.
authors.affiliation: Jeroen Bosch Ziekenhuis, afd. Interne Geneeskunde, 's-Hertogenbosch, the Netherlands. mariekebroes@gmail.com
authors.forename: Marieke J M
authors.initials: MJ
authors.lastname: Broes
authors.forename: Bob F W R
authors.initials: BF
authors.lastname: Roelofs
authors.forename: Aart H
authors.initials: AH
authors.lastname: Mudde
authors.forename: Elske
authors.initials: E
authors.lastname: Hoornenborg
mesh_terms: D000369:Aged, 80 and over; D000892:Anti-Infective Agents, Urinary / Q000009:adverse effects* / Q000627:therapeutic use; D003937:Diagnosis, Differential; D004342:Drug Hypersensitivity / Q000175:diagnosis; D005260:Female; D006801:Humans; D008171:Lung Diseases / Q000139:chemically induced* / Q000175:diagnosis*; D009582:Nitrofurantoin / Q000009:adverse effects* / Q000627:therapeutic use; D011379:Prognosis; D014552:Urinary Tract Infections / Q000188:drug therapy
chemical_list: D000892:Anti-Infective Agents, Urinary; D009582:Nitrofurantoin