title: Effect of water extract of Trichosanthes dioica fruits in streptozotocin induced diabetic rats.
abstract: In rats with streptozotocin induced severe diabetes mellitus, aqueous extract of Trichosanthes dioica fruits at a dose of 1000mg/kg body weight daily once for 28 days reduced the levels of fasting blood glucose, postprandial glucose, asparate amino transferase, alanine amino transferase, alkaline phosphatase, creatinine, urine sugar and urine protein where as total protein and body weight was increased. No toxic effect was observed during LD50. Our study suggests that further detailed toxicity studies and mechanism of action of T. dioica would be useful for undertaking human trials.
authors.affiliation: Alternative Therapeutics Unit, Drug Discovery & Development Division,. Medicinal Research Lab, Department of Chemistry, University of Allahabad, Allahabad, 211002 India.
authors.forename: Prashant Kumar
authors.initials: PK
authors.lastname: Rai
authors.forename: Dolly
authors.initials: D
authors.lastname: Jaiswal
authors.forename: Devendra K
authors.initials: DK
authors.lastname: Rai
authors.forename: Bechan
authors.initials: B
authors.lastname: Sharma
authors.forename: Geeta
authors.initials: G
authors.lastname: Watal
keywords: Antidiabetic effect; Hepatoprotective; Trichosanthes dioica