title: Bowels control brain: gut hormones and obesity.
abstract: Peptide hormones are released from the gastrointestinal tract in response to nutrients and communicate information regarding the current state of energy balance to the brain. These hormones regulate appetite, energy expenditure and glucose homeostasis. They can act either via the circulation at target peripheral tissues, by activation of the vagus nerve or by acting on key brain regions implicated in energy homeostasis such as the hypothalamus and brainstem. This review gives an overview of the main gut hormones implicated in the regulation of food intake and how some of these are being targeted to develop anti obesity treatments.
authors.affiliation: Section of Investigative Medicine, Imperial College London, London, United Kingdom. g.bewick@imperial.ac.uk
authors.forename: Gavin A
authors.initials: GA
authors.lastname: Bewick
mesh_terms: D000818:Animals; D001066:Appetite / Q000187:drug effects / Q000502:physiology; D004435:Eating / Q000187:drug effects; D005768:Gastrointestinal Hormones / Q000378:metabolism* / Q000627:therapeutic use; D006801:Humans; D009765:Obesity / Q000188:drug therapy / Q000378:metabolism*; D036361:Peptide Hormones / Q000378:metabolism / Q000627:therapeutic use
chemical_list: D005768:Gastrointestinal Hormones; D036361:Peptide Hormones