title: Mechanisms of regeneratory effects of baikal aconite diterpene alkaloids.
abstract: Regeneratory activities of Baikal aconite alkaloids were studied on the excision skin wound model. Manifest wound healing effects of songorine, napelline, and hypaconitine were detected. The therapeutic efficiency was based on activation of residual mesenchymal progenitor elements. The development of this phenomenon was explained by the direct effects of alkaloids on precursors and by higher production of growth factors by the skin stromal cells. Songorine exhibited the most pronounced specific activity due to more significant stimulation of progenitor cell differentiation associated with maximum activation of the secretory function of the microenvironment cells.
authors.affiliation: Institute of Pharmacology, Siberian Division of the Russian Academy of Medical Sciences, Tomsk, Russia. zgn@pharm.tsu.ru
authors.forename: G N
authors.initials: GN
authors.lastname: Zyuz'kov
authors.forename: A V
authors.initials: AV
authors.lastname: Krapivin
authors.forename: Yu V
authors.initials: YV
authors.lastname: Nesterova
authors.forename: T N
authors.initials: TN
authors.lastname: Povetieva
authors.forename: V V
authors.initials: VV
authors.lastname: Zhdanov
authors.forename: N I
authors.initials: NI
authors.lastname: Suslov
authors.forename: T I
authors.initials: TI
authors.lastname: Fomina
authors.forename: E V
authors.initials: EV
authors.lastname: Udut
authors.forename: L A
authors.initials: LA
authors.lastname: Miroshnichenko
authors.forename: E V
authors.initials: EV
authors.lastname: Simanina
authors.forename: A A
authors.initials: AA
authors.lastname: Semenov
authors.forename: S S
authors.initials: SS
authors.lastname: Kravtsova
authors.forename: A M
authors.initials: AM
authors.lastname: Dygai
mesh_terms: D000157:Aconitine / Q000031:analogs & derivatives / Q000302:isolation & purification / Q000494:pharmacology; D031841:Aconitum / Q000737:chemistry*; D000470:Alkaloids / Q000302:isolation & purification / Q000494:pharmacology*; D000818:Animals; D021461:Animals, Outbred Strains; D002454:Cell Differentiation / Q000187:drug effects; D060833:Cellular Microenvironment / Q000187:drug effects; D004224:Diterpenes / Q000302:isolation & purification / Q000494:pharmacology*; D036341:Intercellular Signaling Peptides and Proteins / Q000096:biosynthesis / Q000378:metabolism; D008297:Male; D059630:Mesenchymal Stem Cells / Q000187:drug effects; D051379:Mice; D012038:Regeneration / Q000187:drug effects*; D012867:Skin / Q000187:drug effects* / Q000293:injuries; D017154:Stromal Cells / Q000187:drug effects; D014945:Wound Healing / Q000187:drug effects*; D014947:Wounds and Injuries / Q000188:drug therapy* / Q000473:pathology
chemical_list: D000470:Alkaloids; D004224:Diterpenes; D036341:Intercellular Signaling Peptides and Proteins; C109326:napelline; C058309:hypaconitine; C057217:songorine; D000157:Aconitine