title: Oxidant and antioxidant status in vegetarians and fish eaters.
abstract: An adequate antioxidant reserve which is usually present in a vegetarian diet is associated with higher life expectancy. On the other hand habitual consumption of fish is associated with lower risk of cardiovascular diseases which is attributed to the polyunsaturated fatty acids (PUFA) present in it. However the PUFA are readily susceptible to oxidation leading to the formation of free radicals which is known to be involved in the causation of several diseases.The oxidant-antioxidant status of 23 vegetarians and 22 fish eaters was studied by determining the plasma lipid peroxides measured as malondialdehyde (MDA) and the antioxidants, viz. glutathione (GSH), ascorbic acid, ceruloplasmin and uric acid.Results show that the ascorbic acid values were significantly higher in vegetarians. In addition, MDA correlated negatively with ascorbic acid only in vegetarians. However, correlation of MDA with glutathione showed a significant negative correlation only in fish eaters. There was no statistically significant difference in the MDA, GSH, ceruloplasmin and uric acid levels. The mechanism behind these findings are not clear and needs to be explored.
authors.affiliation: Department of Biochemistry, Centre For Basic Sciences, Kasturba Medical College, 575001 Mangalore.
authors.forename: K
authors.initials: K
authors.lastname: Poornima
authors.forename: M
authors.initials: M
authors.lastname: Cariappa
authors.forename: K
authors.initials: K
authors.lastname: Asha
authors.forename: H P
authors.initials: HP
authors.lastname: Kedilaya
authors.forename: M
authors.initials: M
authors.lastname: Nandini
keywords: Antioxidants; ceruloplasmin; free radicals; glutathione; lipid peroxide; malondialdehyde