title: Mechanisms of ventilator dependence in children with neuromuscular and respiratory control disorders identified by monitoring diaphragm electrical activity.
abstract: OBJECTIVE
  To report on the monitoring of diaphragm electrical activity (Edi) using neurally adjusted ventilator assist (NAVA) technology to investigate the mechanisms of ventilator dependence in children with neuromuscular and respiratory control disorders.
  
  
  METHODS
  Using NAVA technology, electrical activity of the diaphragm (Edi) was monitored at the lowest achievable level of respiratory support in six ventilator-dependent patients with neuromuscular and respiratory control disorders, aged 6 weeks to 12 years, admitted to a tertiary paediatric intensive care unit between 2009 and 2011.
  
  
  RESULTS
  Edi monitoring identified markedly abnormal respiratory dynamic patterns that were not always apparent clinically. These were associated with disorders of central respiratory control, muscle weakness and diaphragm pathology.
  
  
  CONCLUSIONS
  Edi monitoring using NAVA technology is a valuable, minimally invasive, diagnostic adjunct in children with neuromuscular and respiratory control disorders who are ventilator-dependent.
authors.affiliation: Evelina Children's Hospital, Guy's & St Thomas' NHS Foundation Trust, London, UK. miriam.fine-goulden@gstt.nhs.uk
authors.forename: Miriam R
authors.initials: MR
authors.lastname: Fine-Goulden
authors.forename: Naga K
authors.initials: NK
authors.lastname: Puppala
authors.forename: Andrew
authors.initials: A
authors.lastname: Durward
mesh_terms: D002648:Child; D002675:Child, Preschool; D003964:Diaphragm / Q000503:physiopathology*; D004568:Electrodiagnosis / Q000295:instrumentation / Q000379:methods*; D006801:Humans; D007223:Infant; D015278:Intensive Care Units, Pediatric; D059725:Interactive Ventilatory Support; D009468:Neuromuscular Diseases / Q000503:physiopathology*; D012129:Respiratory Function Tests / Q000295:instrumentation / Q000379:methods*; D012131:Respiratory Insufficiency / Q000503:physiopathology*; D015300:Ventilator Weaning