title: Toward awakening cryptic secondary metabolite gene clusters in filamentous fungi.
abstract: Mining for novel natural compounds is of eminent importance owing to the continuous need for new pharmaceuticals. Filamentous fungi are historically known to harbor the genetic capacity for an arsenal of natural compounds, both beneficial and detrimental to humans. The majority of these metabolites are still cryptic or silent under standard laboratory culture conditions. Mining for these cryptic natural products can be an excellent source for identifying new compound classes. Capitalizing on the current knowledge on how secondary metabolite gene clusters are regulated has allowed the research community to unlock many hidden fungal treasures, as described in this chapter.
authors.affiliation: Department of Medical Microbiology and Immunology, University of Wisconsin, Madison, Wisconsin, USA.
authors.forename: Fang Yun
authors.initials: FY
authors.lastname: Lim
authors.forename: James F
authors.initials: JF
authors.lastname: Sanchez
authors.forename: Clay C C
authors.initials: CC
authors.lastname: Wang
authors.forename: Nancy P
authors.initials: NP
authors.lastname: Keller
mesh_terms: D001230:Aspergillus / Q000235:genetics* / Q000378:metabolism; D001688:Biological Products / Q000378:metabolism; D053898:Biosynthetic Pathways / Q000235:genetics*; D002843:Chromatin / Q000235:genetics / Q000378:metabolism; D002851:Chromatography, High Pressure Liquid; D005656:Fungal Proteins / Q000235:genetics / Q000378:metabolism; D015966:Gene Expression Regulation, Fungal; D005800:Genes, Fungal; D005809:Genes, Regulator; D025301:Hyphae / Q000378:metabolism; D055442:Metabolome; D055432:Metabolomics / Q000379:methods; D005810:Multigene Family; D011523:Protoplasts / Q000378:metabolism; D015533:Transcriptional Activation; D014170:Transformation, Genetic
chemical_list: D001688:Biological Products; D002843:Chromatin; D005656:Fungal Proteins