title: Animal experimental study of the fully biodegradable atrial septal defect (ASD) occluder.
abstract: This study was conducted to evaluate the feasibility, safety, biocompatibility, and degradation features of a fully biodegradable occluder for closure of atrial septal defect (ASD) in an acute canine model. The ASD was created in 20 healthy mongrel dogs by the brockenbrough needle, and the fully biodegradable occluders were implanted by self-made delivery system. The success rate and complications were observed. Acute ASD models were successfully created in 18 dogs, and 16 occluders were successfully implanted in the ASD models. Animals were sacrificed at different times after procedure. The cardiac gross anatomy showed that all occluders were stable in the interatrial septum, no vegetation or thrombus formation was observed on the surface of all occluders. They were embedded into endogenous host tissue gradually at 12-week follow-up. Different periods of pathological observations suggested that the occluders degraded gradually over about 24 weeks and essentially became an integral part of the septum. Transcatheter closure of ASD in acute canine model using the fully biodegradable ASD occluder has the potential of a high successful rate of technique, excellent biocompatibility, and fewer complications with adequate, immediate, and short-term results.
authors.affiliation: Department of Cardiology, Changhai Hospital, Second Military Medical University, Shanghai 200433, China.
authors.forename: Yu-feng
authors.initials: YF
authors.lastname: Zhu
authors.forename: Xin-miao
authors.initials: XM
authors.lastname: Huang
authors.forename: Jiang
authors.initials: J
authors.lastname: Cao
authors.forename: Jian-qiang
authors.initials: JQ
authors.lastname: Hu
authors.forename: Yuan
authors.initials: Y
authors.lastname: Bai
authors.forename: Hai-bing
authors.initials: HB
authors.lastname: Jiang
authors.forename: Zhao-feng
authors.initials: ZF
authors.lastname: Li
authors.forename: Ying
authors.initials: Y
authors.lastname: Chen
authors.forename: Wei
authors.initials: W
authors.lastname: Wang
authors.forename: Yong-wen
authors.initials: YW
authors.lastname: Qin
authors.forename: Xian-xian
authors.initials: XX
authors.lastname: Zhao
mesh_terms: D020341:Absorbable Implants; D000818:Animals; D004285:Dogs; D004867:Equipment Design; D019544:Equipment Failure Analysis; D005260:Female; D006344:Heart Septal Defects, Atrial / Q000601:surgery*; D008297:Male; D055989:Septal Occluder Device; D016896:Treatment Outcome