title: Synthesis, evaluation and structure-activity relationships of triazine dimers as novel antiviral agents.
abstract: This letter reports the synthesis and structure-activity relationship (SAR) study of a series of triazine dimers as novel antiviral agents. These compounds were obtained through a bivalent ligand approach in which two triazine moieties are covalently connected by suitable linkers. Several compounds showed submicromolar activity against wild-type HIV-1 and moderate activity against single mutant strains.
authors.affiliation: Laboratory of Medicinal Chemistry, University of Antwerp, Universiteitsplein 1, B-2610 Antwerp, Belgium.
authors.forename: Muthusamy
authors.initials: M
authors.lastname: Venkatraj
authors.forename: Kevin K
authors.initials: KK
authors.lastname: Ariën
authors.forename: Jan
authors.initials: J
authors.lastname: Heeres
authors.forename: Jurgen
authors.initials: J
authors.lastname: Joossens
authors.forename: Jonas
authors.initials: J
authors.lastname: Messagie
authors.forename: Johan
authors.initials: J
authors.lastname: Michiels
authors.forename: Pieter
authors.initials: P
authors.lastname: Van der Veken
authors.forename: Guido
authors.initials: G
authors.lastname: Vanham
authors.forename: Paul J
authors.initials: PJ
authors.lastname: Lewi
authors.forename: Koen
authors.initials: K
authors.lastname: Augustyns
mesh_terms: D002460:Cell Line; D019281:Dimerization; D054303:HIV Reverse Transcriptase / Q000037:antagonists & inhibitors / Q000378:metabolism; D015497:HIV-1 / Q000187:drug effects / Q000201:enzymology; D006801:Humans; D018894:Reverse Transcriptase Inhibitors / Q000138:chemical synthesis* / Q000737:chemistry* / Q000494:pharmacology; D013329:Structure-Activity Relationship; D014227:Triazines / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology
chemical_list: D018894:Reverse Transcriptase Inhibitors; D014227:Triazines; D054303:HIV Reverse Transcriptase