title: Dietary total antioxidant capacity from different assays in relation to serum C-reactive protein among young Japanese women.
abstract: BACKGROUND
  The association between dietary total antioxidant capacity (TAC) from different assays and serum C-reactive protein (CRP) has not been assessed in non-Western populations. We examined the association between dietary TAC and serum CRP concentration in young Japanese women using different four TAC assays.
  
  
  METHODS
  The subjects were 443 young Japanese women aged 18-22 years. Dietary TAC was assessed with a self-administered diet history questionnaire and the TAC value of each food using the following four assays: ferric reducing ability of plasma (FRAP); oxygen radical absorbance capacity (ORAC); Trolox equivalent antioxidant capacity (TEAC); and total radical-trapping antioxidant parameter (TRAP). Serum CRP concentrations were measured by highly sensitive nephelometry.
  
  
  RESULTS
  The major contributor to dietary TAC was green, barley, and oolong tea (FRAP: 53%, ORAC: 45%, TEAC: 36%, and TRAP: 44%). The prevalence of elevated CRP concentrations (≥ 1 mg/L) was 5.6%. TAC from FRAP was inversely associated with serum CRP concentrations (adjusted odds ratio [OR] for elevated CRP concentration in high [compared with low] dietary TAC group: 0.39 [95% confidence interval (CI): 0.16-0.98]; P = 0.04). TAC from ORAC was inversely associated with CRP, although the association was not significant (OR: 0.48 [95% CI: 0.20-1.14]; P = 0.10). TAC from TEAC was inversely associated with CRP (OR: 0.32 [95% CI: 0.12-0.82]; P = 0.02), as was TAC from TRAP (OR: 0.31 [95% CI: 0.12-0.81]; P = 0.02).
  
  
  CONCLUSIONS
  Dietary TAC was inversely associated with serum CRP concentration in young Japanese women regardless of assay. Further studies are needed in other populations to confirm these results.
authors.affiliation: Department of Social and Preventive Epidemiology, Graduate School of Medicine, University of Tokyo, Tokyo, Japan.
authors.forename: Satomi
authors.initials: S
authors.lastname: Kobayashi
authors.forename: Kentaro
authors.initials: K
authors.lastname: Murakami
authors.forename: Satoshi
authors.initials: S
authors.lastname: Sasaki
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Uenishi
authors.forename: Mitsuyo
authors.initials: M
authors.lastname: Yamasaki
authors.forename: Hitomi
authors.initials: H
authors.lastname: Hayabuchi
authors.forename: Toshinao
authors.initials: T
authors.lastname: Goda
authors.forename: Jun
authors.initials: J
authors.lastname: Oka
authors.forename: Keiko
authors.initials: K
authors.lastname: Baba
authors.forename: Kazuko
authors.initials: K
authors.lastname: Ohki
authors.forename: Reiko
authors.initials: R
authors.lastname: Watanabe
authors.forename: Yoshiko
authors.initials: Y
authors.lastname: Sugiyamama
mesh_terms: D000293:Adolescent; D000328:Adult; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage* / Q000032:analysis / Q000737:chemistry; D000975:Antioxidants / Q000008:administration & dosage* / Q000032:analysis / Q000737:chemistry; D002097:C-Reactive Protein / Q000032:analysis*; D003430:Cross-Sectional Studies; D004032:Diet / Q000009:adverse effects / Q000208:ethnology; D004034:Diet Surveys; D004046:Dietetics / Q000193:education; D005260:Female; D005504:Food Analysis / Q000379:methods*; D006801:Humans; D007564:Japan; D009391:Nephelometry and Turbidimetry; D011795:Surveys and Questionnaires; D000078329:Workforce; D055815:Young Adult
chemical_list: D000893:Anti-Inflammatory Agents; D000975:Antioxidants; D002097:C-Reactive Protein