title: Synthesis and bioactivity study of 2-acylamino-substituted N'-benzylbenzohydrazide derivatives.
abstract: The discovery of new safe and effective pesticides is one of the main means of providing eco-friendly agricultural agents for modern crop protection. To identify new biological molecules based of the anthranilic diamide skeleton of the novel pesticide chlorantraniliprole, which acts on the ryanodine receptor and functional groups in acyl hydrazine insect growth regulators, more than 40 new compounds of 2-acylamino-substituted N'-benzylbenzohydrazide derivatives were designed and synthesized. The structures of the new compounds were characterized using (1)H nuclear magnetic resonance (NMR), high-resolution mass spectrometry (HRMS), or electron impact mass spectrometry (EI-MS), and their biological activities at a concentration of 600 mg L(-1) were determined against cotton aphid (Aphis gossypii Glover), carmine spider mite (Tetranychus cinnabarinus), and diamondback moth (Plutella xylostella). The results of a preliminary assay showed that compounds 6a-I-2 and 6d-III-4 maintained the lethal activity of anthranilic diamide against P. xylostella; compounds 6c-II-4, 6d-I-7, 6d-II-1, and 6d-III-5 exhibited good lethal activity against A. gossypii; and compounds 6a-II-1, 6a-III-1, 6b-I-7, 6c-I-1, and 6c-III-5 retained promising larvicidal activities against T. cinnabarinus. In subsequent further tests against T. cinnabarinus, compounds 6a-II-1, 6a-III-1, 6c-I-1, and 6c-III-5 showed an LC(50) value of <90 mg L(-1); especially, the LC(50) of compound 6a-III-1 was only 27.9 mg L(-1). In conclusion, the introduction of the functional fragment-substituted acyl hydrazine improved the acaricidal activity of the anthranilic diamide skeleton, and the halogen atom at X position and the methyl group at R(1) play crucial roles in the biological activities of the compounds.
authors.affiliation: Department of Applied Chemistry, College of Science, China Agricultural University, Beijing 100193, People's Republic of China.
authors.forename: Junjun
authors.initials: J
authors.lastname: Ou
authors.forename: Xiaokun
authors.initials: X
authors.lastname: Zhu
authors.forename: Lei
authors.initials: L
authors.lastname: Wang
authors.forename: Chuan
authors.initials: C
authors.lastname: Xu
authors.forename: Feng
authors.initials: F
authors.lastname: Liu
authors.forename: Long
authors.initials: L
authors.lastname: Ren
authors.forename: Xibao
authors.initials: X
authors.lastname: Xu
authors.forename: Yi
authors.initials: Y
authors.lastname: Wang
authors.forename: Changhui
authors.initials: C
authors.lastname: Rui
authors.forename: Shangzhong
authors.initials: S
authors.lastname: Liu
mesh_terms: D000588:Amines / Q000737:chemistry*; D000818:Animals; D001042:Aphids; D006834:Hydrazines / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D007306:Insecticides / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D009682:Magnetic Resonance Spectroscopy; D009036:Moths; D021241:Spectrometry, Mass, Electrospray Ionization; D040102:Tetranychidae
chemical_list: D000588:Amines; D006834:Hydrazines; D007306:Insecticides