title: Uvaridacols E-H, highly oxygenated antiausterity agents from Uvaria dac.
abstract: Chemical investigation of the stems of Uvaria dac yielded four new highly oxygenated cyclohexene derivatives named uvaridacols E-H (1-4). Their structures were established through NMR and circular dichroism spectroscopic analysis. Uvaridacols E (1), F (2), and H (4) displayed weak preferential cytotoxicity against PANC-1 human pancreatic cancer cells under nutrition-deprived conditions in a concentration-dependent manner, without causing toxicity in normal nutrient-rich conditions.
authors.affiliation: Frontier Research Core for Life Sciences, University of Toyama , 2630 Sugitani, Toyama 930-0194, Japan.
authors.forename: Suresh
authors.initials: S
authors.lastname: Awale
authors.forename: Jun-ya
authors.initials: JY
authors.lastname: Ueda
authors.forename: Sirivan
authors.initials: S
authors.lastname: Athikomkulchai
authors.forename: Dya Fita
authors.initials: DF
authors.lastname: Dibwe
authors.forename: Sherif
authors.initials: S
authors.lastname: Abdelhamed
authors.forename: Satoru
authors.initials: S
authors.lastname: Yokoyama
authors.forename: Ikuo
authors.initials: I
authors.lastname: Saiki
authors.forename: Ryuta
authors.initials: R
authors.lastname: Miyatake
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D053138:Cyclohexenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D010190:Pancreatic Neoplasms / Q000188:drug therapy; D018547:Plant Stems / Q000737:chemistry; D013785:Thailand; D031046:Uvaria / Q000737:chemistry*
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D053138:Cyclohexenes