title: Lipid peroxidation and glutathione peroxidase in ischemic heart disease.
abstract: With the growing interest in the concept of free radicals in the pathogenesis of myocardial ischemia, it was thought worthwhile to study the changes in lipid peroxides and antioxidant enzyme glutathione peroxidase (GPx) in ischemic heart disease (IHD). The study was carried out on 76 patients of IHD-38 of acute myocardial infarction (AMI) and 38 of stable ischemic heart disease (SIDH). They were age and sex matched with 38 normal healthy controls. A significant increase (p<0.001) in lipid peroxides as malondialdehyde (MDA) (5.9±0.7 mmol/L) and a decrease in GPx (24.6±2.2 U/gmHb) was found in patients of AMI when compared with controls. There was no significant difference in these values in SIHD. Thus this study confirms the earlier findings that MDA and GPx are useful parameters in IHD and their magnitude is dependent on severity and/or duration of ischemia. We suggest that these tests would be of use in smaller institutions with limited facilities.
authors.affiliation: Dept of Biochemistry, Indira Gandhi Medical College and Mayo Hospital, Central Avenue, 440018 Nagpur.
authors.forename: K S
authors.initials: KS
authors.lastname: Motghare
authors.forename: A
authors.initials: A
authors.lastname: Bhutey
authors.forename: B B
authors.initials: BB
authors.lastname: Murrhar
authors.forename: M
authors.initials: M
authors.lastname: Gupta
authors.forename: A W
authors.initials: AW
authors.lastname: Meshram
authors.forename: Y
authors.initials: Y
authors.lastname: Balsubramanium
keywords: Glutathione peroxidase; IHD; Lipid peroxidation