title: Raw and test-thaw semen parameters after cryopreservation among men with newly diagnosed cancer.
abstract: OBJECTIVE
  To characterize sperm parameters from thawed semen samples of men with different cancers who cryopreserved semen before oncologic therapy.
  
  
  METHODS
  Retrospective cohort study.
  
  
  METHODS
  Tertiary academic medical center.
  
  
  METHODS
  1,010 semen samples collected between 1994 to 2010.
  
  
  METHODS
  None.
  
  
  METHODS
  Mean total motile count (TMC), change in percentage motility and percentage survival (100 * [postthaw % motility/raw % motility]) for each cancer compared with data from samples of men without cancer (the "procreative management" group), and proportion of postthaw samples with TMC >5 × 10(6).
  
  
  RESULTS
  The procreative management group had the best raw and postthaw semen quality. The best raw and postthaw semen quality for cancer patients occurred in those with prostate cancer (TMC of 155.1 and 53.2 × 10(6), respectively) and the worst in those with leukemias. Lymphoid leukemias demonstrated the worst raw TMC (26.8 × 10(6)), but myeloid leukemias displayed the worst postthaw TMC (6.9 × 10(6)). The testicular cancer group was the only group with a statistically significantly lower chance of having TMC >5 × 10(6).
  
  
  CONCLUSIONS
  Men with testicular cancer were most commonly referred for sperm cryopreservation and were the only group that was statistically significantly less likely to have TMC >5 × 10(6) on postthaw semen analysis. The most severe reduction in TMC was seen in the myeloid leukemia group, suggesting that these patients along with men with testis cancer and those with lymphoid leukemia should be counseled to provide increased numbers of specimens for fertility preservation.
authors.affiliation: Department of Urology, University of Washington, Seattle, Washington 98195, USA.
authors.forename: James M
authors.initials: JM
authors.lastname: Hotaling
authors.forename: Natalya A
authors.initials: NA
authors.lastname: Lopushnyan
authors.forename: Michael
authors.initials: M
authors.lastname: Davenport
authors.forename: Heather
authors.initials: H
authors.lastname: Christensen
authors.forename: Erin R
authors.initials: ER
authors.lastname: Pagel
authors.forename: Charles H
authors.initials: CH
authors.lastname: Muller
authors.forename: Thomas J
authors.initials: TJ
authors.lastname: Walsh
mesh_terms: D000328:Adult; D015925:Cryopreservation / Q000706:statistics & numerical data*; D006801:Humans; D008297:Male; D009369:Neoplasms / Q000453:epidemiology / Q000473:pathology*; D012661:Semen / Q000166:cytology*; D055101:Semen Analysis / Q000706:statistics & numerical data*; D012662:Semen Preservation / Q000706:statistics & numerical data*; D014861:Washington / Q000453:epidemiology