title: Iron-mediated regulation of metalloprotease VvpE production in Vibrio vulnificus.
abstract: In Vibrio vulnificus, the production of metalloprotease VvpE is controlled by Crp (cAMP-receptor protein) and SmcR (a quorum sensing regulator) at the transcription level, and by PilD-mediated type II general secretion system (TTGSS) at the extracellular secretion level. Iron is known to stimulate VvpE production but the related mechanisms remain unidentified. Iron stimulated vvpE transcription and extracellular VvpE production even in the background with a crp and/or smcR mutation. Iron stimulated the transcription of pilD encoding an essential element of TTGSS. Therefore, iron seems to stimulate vvpE transcription through factor(s) other than Crp and SmcR, and to facilitate extracellular VvpE production by increasing the activity of TTGSS.
authors.affiliation: Research Center for Resistant Cells, Chosun University Medical School.
authors.forename: Choon-Mee
authors.initials: CM
authors.lastname: Kim
authors.forename: Sam-Cheol
authors.initials: SC
authors.lastname: Kim
authors.forename: Sung-Heui
authors.initials: SH
authors.lastname: Shin
mesh_terms: D001426:Bacterial Proteins / Q000235:genetics* / Q000378:metabolism; D015964:Gene Expression Regulation, Bacterial; D015971:Gene Expression Regulation, Enzymologic; D006801:Humans; D007501:Iron / Q000378:metabolism*; D045726:Metalloproteases / Q000235:genetics* / Q000378:metabolism; D014735:Vibrio Infections / Q000382:microbiology; D041261:Vibrio vulnificus / Q000201:enzymology* / Q000235:genetics / Q000378:metabolism
chemical_list: D001426:Bacterial Proteins; D007501:Iron; D045726:Metalloproteases