title: Physiochemical properties and prolonged release behaviours of chitosan-denatured β-lactoglobulin microcapsules for potential food applications.
abstract: Chitosan (CS) and β-lactoglobulin (βlg) double-wall coating was designed as a shell structure to achieve prolonged release of core material in the gastrointestinal tract (GI) for potential food applications. A model core material, brilliant blue (BB) dye, was incorporated into CS as the primary wall material, and subsequently, denatured βlg, a secondary wall material, was used to coat the outer layer. The strongest interaction occurred between 0.5% (w/v) βlg and 0.5% (w/v) CS at pH 5.5 ± 0.1, where the opposite charges of CS and βlg formed a complex, which is especially favourable in acidic beverage systems. Under simulated stomach conditions, a denatured-βlg coat resisted acid conditions and pepsin hydrolysis for 2h. While mimicking small intestine conditions, βlg was degraded by pancreatin, causing the release of BB-loaded CS to the intestinal fluid at a constant rate. The sustained release of core material later in the GI tract provided an optimal absorption rate in the small intestine.
authors.affiliation: Department of Food Science and Technology, Sejong University, 98 Gunja-dong, Gwangjin gu, Seoul 143-747, Republic of Korea. sherrene_lps@yahoo.com.sg
authors.forename: Pei Sia
authors.initials: PS
authors.lastname: Lee
authors.forename: Sun Goo
authors.initials: SG
authors.lastname: Yim
authors.forename: Yeri
authors.initials: Y
authors.lastname: Choi
authors.forename: Thi
authors.initials: T
authors.lastname: Van Anh Ha
authors.forename: Sanghoon
authors.initials: S
authors.lastname: Ko
mesh_terms: D002214:Capsules / Q000737:chemistry / Q000378:metabolism; D055598:Chemical Phenomena; D048271:Chitosan / Q000737:chemistry* / Q000378:metabolism; D003692:Delayed-Action Preparations / Q000737:chemistry* / Q000378:metabolism; D004063:Digestion; D016503:Drug Delivery Systems; D041981:Gastrointestinal Tract / Q000737:chemistry / Q000378:metabolism*; D006801:Humans; D007700:Kinetics; D007782:Lactoglobulins / Q000737:chemistry* / Q000378:metabolism; D008954:Models, Biological; D013499:Surface Properties
chemical_list: D002214:Capsules; D003692:Delayed-Action Preparations; D007782:Lactoglobulins; D048271:Chitosan