title: A lipid mediator controls neutrophil recruitment in acute lung injury--should we really be surprised?
abstract: New therapeutic approaches are sorely needed for acute lung injury. Neutrophil recruitment is a pathological hallmark of this syndrome, and is mainly regulated by CXC chemokine receptor 2 and its ligand CXC ligand 1. Rossaint and colleagues have described a new mechanism for regulation of this axis by 12/15-lipoxygenase products. This work opens the door for new therapeutic approaches and highlights the crucial interplay between lipid mediators and chemokines, a time-honored but often-ignored concept.
authors.forename: Zbigniew
authors.initials: Z
authors.lastname: Zasłona
authors.forename: Marc
authors.initials: M
authors.lastname: Peters-Golden
mesh_terms: D055371:Acute Lung Injury / Q000201:enzymology* / Q000473:pathology*; D000818:Animals; D001092:Arachidonate 12-Lipoxygenase / Q000172:deficiency*; D001093:Arachidonate 15-Lipoxygenase / Q000172:deficiency*; D004195:Disease Models, Animal; D020556:Neutrophil Infiltration / Q000502:physiology*
chemical_list: D001092:Arachidonate 12-Lipoxygenase; D001093:Arachidonate 15-Lipoxygenase