title: The sigma-1 receptor: roles in neuronal plasticity and disease.
abstract: Sigma-1 receptors (Sig-1Rs) have been implicated in many neurological and psychiatric conditions. Sig-1Rs are intracellular chaperones that reside specifically at the endoplasmic reticulum (ER)-mitochondrion interface, referred to as the mitochondrion-associated ER membrane (MAM). Here, Sig-1Rs regulate ER-mitochondrion Ca(2+) signaling. In this review, we discuss the current understanding of Sig-1R functions. Based on this, we suggest that the key cellular mechanisms linking Sig-1Rs to neurological disorders involve the translocation of Sig-1Rs from the MAM to other parts of the cell, whereby Sig-1Rs bind and modulate the activities of various ion channels, receptors, or kinases. Thus, Sig-1Rs and their associated ligands may represent new avenues for treating aspects of neurological and psychiatric diseases.
authors.affiliation: Synaptic Plasticity Section, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Department of Health and Human Services, Baltimore, MD, USA.
authors.forename: Saïd
authors.initials: S
authors.lastname: Kourrich
authors.forename: Tsung-Ping
authors.initials: TP
authors.lastname: Su
authors.forename: Michiko
authors.initials: M
authors.lastname: Fujimoto
authors.forename: Antonello
authors.initials: A
authors.lastname: Bonci
mesh_terms: D000818:Animals; D020013:Calcium Signaling / Q000502:physiology; D004721:Endoplasmic Reticulum / Q000378:metabolism; D006801:Humans; D001523:Mental Disorders / Q000378:metabolism*; D008928:Mitochondria / Q000378:metabolism; D009473:Neuronal Plasticity / Q000502:physiology*; D017480:Receptors, sigma / Q000502:physiology*; D000097605:Sigma-1 Receptor
chemical_list: D017480:Receptors, sigma; D000097605:Sigma-1 Receptor