title: Total synthesis of aeruginosin 98B.
abstract: The first total synthesis of aeruginosin 98B was accomplished. The key step is a highly diastereoselective Pd-catalyzed intramolecular asymmetric allylic alkylation reaction of a diastereomeric mixture of allylic carbonates that is enabled by the use of racemic phosphine ligand L1.
authors.affiliation: Department of Chemistry, Stanford University, Stanford, California 94305-5080, USA. bmtrost@stanford.edu
authors.forename: Barry M
authors.initials: BM
authors.lastname: Trost
authors.forename: Toshiyuki
authors.initials: T
authors.lastname: Kaneko
authors.forename: Neil G
authors.initials: NG
authors.lastname: Andersen
authors.forename: Christoph
authors.initials: C
authors.lastname: Tappertzhofen
authors.forename: Bruce
authors.initials: B
authors.lastname: Fahr
mesh_terms: D000478:Alkylation; D002384:Catalysis; D009842:Oligopeptides / Q000138:chemical synthesis*; D010165:Palladium / Q000737:chemistry
chemical_list: D009842:Oligopeptides; C472547:aeruginosin 98-B; D010165:Palladium