title: Fasting remnant lipoproteins can predict postprandial hyperlipidemia.
abstract: BACKGROUND
  Hypertriglyceridemia and postprandial hyperlipidemia is thought to play an important role in atherosclerosis, but to select patients at high-risk for cardiovascular diseases is difficult with triglycerides (TG) alone in these patients.
  
  
  METHODS
  To predict postprandial hyperlipidemia without inconvenient test meal loading, we examined lipid concentrations before and after test meal loading and fasting adiponectin, and investigated which of these other than TG were significant during the fasting period in 45 healthy individuals (men: women, 26:19).
  
  
  RESULTS
  TG, remnant-like particle-cholesterol and -triglyceride (RemL-C, RLP-C, and RLP-TG), and TG/apolipoprotein(apo)B were significantly elevated after loading and fasting values significantly and positively correlated with incremental area under the curve (iAUC) (r=0.80, r=0.79, r=0.63, r=0.58, r=0.54; p<0.0001). Fasting adiponectin positively correlated with fasting high-density lipoprotein-cholesterol (r=0.43, p<0.005) and apoA-I (r=0.34, p<0.05), and negatively correlated with iAUC of TG, RemL-C, RLP-C, RLP-TG, and TG/apoB (r=-0.37, r=-0.41, r=-0.37, r=-0.36, r=-0.37; p<0.05). We constructed the model of multivariable linear regression analysis without fasting TG. In the sex-, BMI-, age-, and waist circumference-adjusted analysis of postprandial TG elevation 2 h after test meal loading in all participants, RemL-C, RLP-C, RLP-TG, and TG/apoB were significant factors, but adiponectin was not.
  
  
  CONCLUSIONS
  Fasting triglyceride-rich lipoprotein-related values, especially RemL-C, RLP-C, RLP-TG, and TG/apoB are useful predictors of postprandial hyperlipidemia in young healthy individuals. Although fasting adiponectin concentration correlated with the iAUCs for TG, RemL-C, RLP-C, RLP-TG, and TG/apoB, it was not a significant predictor of postprandial hyperlipidemia in multivariable linear regression analysis.
authors.affiliation: Division of Clinical Nutrition, Faculty of Nutrition, Kobe Gakuin University, 518 Arise, Ikawadani-cho, Nishi-ku, Kobe, 651-2180, Japan.
authors.forename: Tomoki
authors.initials: T
authors.lastname: Nagata
authors.forename: Daisuke
authors.initials: D
authors.lastname: Sugiyama
authors.forename: Takako
authors.initials: T
authors.lastname: Kise
authors.forename: Satomi
authors.initials: S
authors.lastname: Tsuji
authors.forename: Hideo
authors.initials: H
authors.lastname: Ohira
authors.forename: Itsuko
authors.initials: I
authors.lastname: Sato
authors.forename: Mari
authors.initials: M
authors.lastname: Yamamoto
authors.forename: Hitomi
authors.initials: H
authors.lastname: Kohsaka
authors.forename: Seiji
authors.initials: S
authors.lastname: Kawano
authors.forename: Shizuya
authors.initials: S
authors.lastname: Yamashita
authors.forename: Yuichi
authors.initials: Y
authors.lastname: Ishikawa
authors.forename: Yoshio
authors.initials: Y
authors.lastname: Fujioka
mesh_terms: D052242:Adiponectin / Q000097:blood*; D000328:Adult; D001053:Apolipoproteins / Q000097:blood; D002784:Cholesterol / Q000097:blood; D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D005215:Fasting; D005260:Female; D018530:Gastric Stump; D006801:Humans; D006949:Hyperlipidemias / Q000097:blood* / Q000473:pathology; D016014:Linear Models; D008074:Lipoproteins / Q000097:blood; D008077:Lipoproteins, LDL / Q000097:blood*; D008297:Male; D008875:Middle Aged; D019518:Postprandial Period; D014280:Triglycerides / Q000097:blood
chemical_list: D052242:Adiponectin; D001053:Apolipoproteins; D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D008074:Lipoproteins; D008077:Lipoproteins, LDL; D014280:Triglycerides; C030087:lipoprotein triglyceride; C099252:oxidized low density lipoprotein; C112017:remnant-like particle cholesterol; D002784:Cholesterol