title: Outcomes assessment of the surgical management of esophageal cancer in younger and older patients.
abstract: BACKGROUND
  The aim of this study was to assess the influence of age on disease presentation, clinical and pathologic staging, postoperative outcomes, costs, and long-term survival after esophagectomy for esophageal malignancy.
  
  
  METHODS
  All patients undergoing esophagectomy for cancer between 1991 and 2011 were prospectively enrolled in an Institutional Review Board approved database.
  
  
  RESULTS
  A total of 493 patients underwent surgical resection during the study period; 58 (11.76%) of these patients were 50 years or less (44 ± 4.7) and 435 patients were greater than 50 years (67 ± 8.44). There was no difference in clinical stage; however, patients 50 years or less were more likely to have adenocarcinoma and reduced Charlson comorbidity index and younger patients tended to have a more delayed presentation as manifested by an increased period of dysphagia and a greater degree of weight loss. In the 50 or less age group there was a significantly greater use of neoadjuvant therapy in stage II patients and the use of neoadjuvant chemotherapy significantly decreased with increasing age. Surgery in the 50 or less age group was associated with significantly reduced intensive care unit stay, incidence of postoperative complications, and overall costs. Multivariate analysis also confirmed associations between increasing age and increased incidence of postoperative complications and cost. There were no significant differences in pathologic stage, positive resection margins, incidence of complete response to neoadjuvant therapy, or in overall survival.
  
  
  CONCLUSIONS
  This study demonstrates younger patients have fewer complications and lower overall treatment costs after esophagectomy. In spite of having a more delayed presentation, younger patients presented with a similar stage and demonstrated similar overall survival.
authors.affiliation: Department of Thoracic Surgery, Virginia Mason Medical Center, Seattle, Washington, USA.
authors.forename: Sheraz R
authors.initials: SR
authors.lastname: Markar
authors.forename: Alan
authors.initials: A
authors.lastname: Karthikesalingam
authors.forename: Donald E
authors.initials: DE
authors.lastname: Low
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D004938:Esophageal Neoplasms / Q000401:mortality* / Q000473:pathology / Q000601:surgery*; D016629:Esophagectomy; D006801:Humans; D008875:Middle Aged; D009367:Neoplasm Staging; D017063:Outcome Assessment, Health Care; D011446:Prospective Studies; D015996:Survival Rate