title: Nucleosome positioning and transcription: fission yeast CHD remodellers make their move.
abstract: Regularly positioned nucleosomes are a common feature of 5' ends of most eukaryotic genes. A series of three studies, Shim et al (2012) and Pointner et al (2012) in this issue of The EMBO Journal and Hennig et al (2012) in EMBO Reports, now show that in the fission yeast Schizosaccharomyces pombe this intragenic nucleosome positioning mostly requires two ATP-dependent remodellers of the CHD family, Hrp1 and Hrp3. Moreover, they suggest that Hrp1- and Hrp3-dependent nucleosome spacing contributes to the silencing of cryptic antisense transcription.
authors.affiliation: INSERM, U823, Université Joseph Fourier - Grenoble 1, Institut Albert Bonniot, Faculté de Médecine, La Tronche Cedex, France.
authors.forename: Leila
authors.initials: L
authors.lastname: Touat-Todeschini
authors.forename: Edwige
authors.initials: E
authors.lastname: Hiriart
authors.forename: André
authors.initials: A
authors.lastname: Verdel
mesh_terms: D000251:Adenosine Triphosphatases / Q000502:physiology*; D000255:Adenosine Triphosphate / Q000737:chemistry*; D004265:DNA Helicases / Q000502:physiology*; D004268:DNA-Binding Proteins / Q000502:physiology*; D022041:Euchromatin / Q000737:chemistry*; D015966:Gene Expression Regulation, Fungal; D006570:Heterochromatin / Q000737:chemistry*; D009707:Nucleosomes / Q000378:metabolism*; D012441:Saccharomyces cerevisiae / Q000378:metabolism*; D029701:Saccharomyces cerevisiae Proteins / Q000502:physiology*; D012568:Schizosaccharomyces / Q000378:metabolism*; D029702:Schizosaccharomyces pombe Proteins / Q000502:physiology*
chemical_list: C489847:CHD1 protein, S cerevisiae; D004268:DNA-Binding Proteins; D022041:Euchromatin; D006570:Heterochromatin; D009707:Nucleosomes; D029701:Saccharomyces cerevisiae Proteins; D029702:Schizosaccharomyces pombe Proteins; D000255:Adenosine Triphosphate; D000251:Adenosine Triphosphatases; C464653:Hrp3 protein, S pombe; C111321:hrp1 protein, S pombe; D004265:DNA Helicases