title: TRPM channels phosphorylation as a potential bridge between old signals and novel regulatory mechanisms of insulin secretion.
abstract: Transient receptor potential channels, especially the members of the melastatin family (TRPM), participate in insulin secretion. Some of them are substrates for protein kinases, which are involved in several neurotransmitter, incretin and hormonal signaling cascades in β cells. The functional relationships between protein kinases and TRPM channels in systems of heterologous expression and native tissues rise issues about novel regulation pathways of pancreatic β-cell excitability. The aim of the present work is to review the evidences about phosphorylation of TRPM channels in β cells and to discuss the perspectives on insulin secretion.
authors.affiliation: Instituto de Fisiologia Celular, Universidad Nacional Autonoma de Mexico. Division de Neurociencias, Departamento de Neurodesarrollo y Fisiologia, Mexico. cmanlio@email.ifc.unam.mx
authors.forename: Carlos Manlio
authors.initials: CM
authors.lastname: Diaz-Garcia
authors.forename: Carmen
authors.initials: C
authors.lastname: Sanchez-Soto
authors.forename: Marcia
authors.initials: M
authors.lastname: Hiriart
mesh_terms: D000818:Animals; D002460:Cell Line; D002470:Cell Survival; D006801:Humans; D007328:Insulin / Q000378:metabolism*; D000078790:Insulin Secretion; D050417:Insulin-Secreting Cells / Q000378:metabolism*; D051379:Mice; D018345:Mice, Knockout; D010766:Phosphorylation; D020794:Receptor Protein-Tyrosine Kinases / Q000378:metabolism*; D015398:Signal Transduction / Q000502:physiology*; D050053:TRPM Cation Channels / Q000378:metabolism*
chemical_list: D007328:Insulin; D050053:TRPM Cation Channels; D020794:Receptor Protein-Tyrosine Kinases