title: Toll like receptor 4 D299G associates with disease progression in Caucasian patients with chronic HBV infection: relationship with gender.
abstract: This study aimed to verify whether rs4986790 A > G single nucleotide polymorphism of toll like receptor 4 (TLR-4) associates with a more severe course of hepatitis B virus (HBV) chronic infection. A cross-sectional study enrolled 191 Caucasian HBV-positive patients: 28 HBsAg + inactive carriers, 121 chronic hepatitis B, 42 HBsAg + transplant candidates. A longitudinal study included 94 patients followed-up for a median time of 19.3 years. TLR-4 rs4986790 A/A genotype was carried less frequently in male HBsAg + inactive carriers than in males with HBsAg + active chronic infection (12/17 Vs 109/121, p = 0.022). At stepwise logistic regression analysis, the carriage of TLR-4 rs4986790 A/A genotype was found to be and independent predictor of liver fibrosis (O.R. 14.8, p = 0.019). In conclusion, in HBV-positive Caucasian patients, the A/A genotype of the rs4986790 polymorphism may influence a worse outcome of chronic HBV infection, mainly through a synergistic interaction with male gender.
authors.forename: Annarosa
authors.initials: A
authors.lastname: Cussigh
authors.forename: Carlo
authors.initials: C
authors.lastname: Fabris
authors.forename: Giovanna
authors.initials: G
authors.lastname: Fattovich
authors.forename: Edmondo
authors.initials: E
authors.lastname: Falleti
authors.forename: Sara
authors.initials: S
authors.lastname: Cmet
authors.forename: Davide
authors.initials: D
authors.lastname: Bitetto
authors.forename: Eleonora
authors.initials: E
authors.lastname: Bignulin
authors.forename: Pierluigi
authors.initials: P
authors.lastname: Toniutto
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000483:Alleles; D003430:Cross-Sectional Studies; D018450:Disease Progression; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D019694:Hepatitis B, Chronic / Q000235:genetics*; D006801:Humans; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D012737:Sex Factors; D051197:Toll-Like Receptor 4 / Q000235:genetics*; D044465:White People; D055815:Young Adult
chemical_list: D051197:Toll-Like Receptor 4