title: Anticancer activity of chemically prepared shrimp low molecular weight chitin evaluation with the human monocyte leukaemia cell line, THP-1.
abstract: In the present study, anticancer activities of chitin, chitosan and low molecular weight chitin were evaluated using a human tumour cell line, THP-1. A molecular weight-activity relationship and an electrostatic interaction-activity relationship were determined. The cytotoxic effects of chitin and derivatives were also evaluated using a normal human foetal lung fibroblastic cell line, MRC-5 and the specific cytotoxicity of chitin and derivatives to tumour cell lines was demonstrated. The high antitumour effect of low molecular weight of chitin was established.
authors.affiliation: Laboratoire BIOGEP, Ecole Nationale Polytechnique, 10 Avenue Pasteur, El Harrach, Alger, Algeria.
authors.forename: R
authors.initials: R
authors.lastname: Salah
authors.forename: P
authors.initials: P
authors.lastname: Michaud
authors.forename: F
authors.initials: F
authors.lastname: Mati
authors.forename: Z
authors.initials: Z
authors.lastname: Harrat
authors.forename: H
authors.initials: H
authors.lastname: Lounici
authors.forename: N
authors.initials: N
authors.lastname: Abdi
authors.forename: N
authors.initials: N
authors.lastname: Drouiche
authors.forename: N
authors.initials: N
authors.lastname: Mameri
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D045744:Cell Line, Tumor; D002686:Chitin / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D003603:Cytotoxins / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D005347:Fibroblasts / Q000378:metabolism; D006801:Humans; D007951:Leukemia, Myeloid / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology; D033561:Penaeidae / Q000737:chemistry*
chemical_list: D000970:Antineoplastic Agents; D003603:Cytotoxins; D002686:Chitin