title: Preliminary evaluation of the safety and efficacy of standard intravenous immunoglobulins in pregnant women with primary cytomegalovirus infection.
abstract: Hyperimmune globulins were reported to prevent and treat fetal cytomegalovirus (CMV) infection during pregnancy. Here, we report that infusions of standard human intravenous immunoglobulin significantly increase CMV IgG titers and avidity indexes in pregnant women, paving the way to their use for passive transfer of maternal CMV humoral immunity to fetuses. Preliminary data on perinatal outcomes of the first 67 newborns are encouraging.
authors.affiliation: Microbiology and Virology Unit, General Hospital of Pescara, Pescara, Italy.
authors.forename: Ennio
authors.initials: E
authors.lastname: Polilli
authors.forename: Giustino
authors.initials: G
authors.lastname: Parruti
authors.forename: Francesca
authors.initials: F
authors.lastname: D'Arcangelo
authors.forename: Elisa
authors.initials: E
authors.lastname: Tracanna
authors.forename: Luigi
authors.initials: L
authors.lastname: Clerico
authors.forename: Vincenzo
authors.initials: V
authors.lastname: Savini
authors.forename: Francesco
authors.initials: F
authors.lastname: D'Antonio
authors.forename: Maurizio
authors.initials: M
authors.lastname: Rosati
authors.forename: Lamberto
authors.initials: L
authors.lastname: Manzoli
authors.forename: Domenico
authors.initials: D
authors.lastname: D'Antonio
authors.forename: Giovanni
authors.initials: G
authors.lastname: Nigro
mesh_terms: D000328:Adult; D003586:Cytomegalovirus Infections / Q000628:therapy*; D005260:Female; D006801:Humans; D016756:Immunoglobulins, Intravenous / Q000627:therapeutic use*; D007167:Immunotherapy / Q000379:methods*; D007262:Infusions, Intravenous; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000628:therapy*; D037841:Pregnant People
chemical_list: D016756:Immunoglobulins, Intravenous