title: Chitosan-sodium alginate blended polyelectrolyte complexes as potential multiparticulate carrier system: colon-targeted delivery and gamma scintigraphic imaging.
abstract: OBJECTIVE
  The objective of this study is to develop stable, biodegradable chitosan-sodium alginate-based dual, ionic cross-linked multiparticulate system (microbeads) of tinidazole for targeted colon delivery and sustained drug release for the treatment of amoebiasis and thereby evaluating its targeting approach through in vivo gamma scintigraphic imaging technique.
  
  
  METHODS
  The chitosan-sodium alginate-based multiparticulate system developed was producing sustained effect by virtue of its mechanical strength using double ionotropic gelation method utilizing calcium chloride and sodium sulfate as first and second cross-linkers respectively. Prepared formulations were evaluated for percent yield, drug entrapment efficiency, particle size, degree of swelling, in vitro kinetics, and in vivo targeting potentials using gamma scintigraphic imaging technique.
  
  
  RESULTS
  The obtained particulates were spherical, free flowing, and had a mean particle size ranging from 1.422 mm to 1.881 mm, whereas percent yield and percent drug entrapment efficiency was found to be in between 72.61 to 82.43% and 63.25 to 79.32% respectively.
  
  
  CONCLUSIONS
  The prepared multiparticulate system showed better sustained release property and in vivo ability to target colon for drug delivery. Hence, the developed multiparticulate system could be a promising device to achieve greater site-specificity to colon.
authors.affiliation: Guru Ghasidas Central University, Institute of Pharmaceutical Sciences, Department of Pharmaceutics, Bilaspur - 495009 (CG), India.
authors.forename: Sanjay K
authors.initials: SK
authors.lastname: Lanjhiyana
authors.forename: Pranav
authors.initials: P
authors.lastname: Bajpayee
authors.forename: Karthikeyan
authors.initials: K
authors.lastname: Kesavan
authors.forename: Sweety
authors.initials: S
authors.lastname: Lanjhiyana
authors.forename: Madaswamy S
authors.initials: MS
authors.lastname: Muthu
mesh_terms: D000464:Alginates / Q000737:chemistry*; D000818:Animals; D000994:Antitrichomonal Agents / Q000008:administration & dosage / Q000493:pharmacokinetics*; D002626:Chemistry, Pharmaceutical; D048271:Chitosan / Q000737:chemistry*; D003106:Colon / Q000000981:diagnostic imaging / Q000378:metabolism*; D003692:Delayed-Action Preparations; D004337:Drug Carriers; D016503:Drug Delivery Systems / Q000379:methods; D020723:Glucuronic Acid / Q000737:chemistry; D006603:Hexuronic Acids / Q000737:chemistry; D008297:Male; D008863:Microspheres; D015609:Organotechnetium Compounds; D010316:Particle Size; D011877:Radionuclide Imaging; D019275:Radiopharmaceuticals; D051381:Rats; D014011:Tinidazole / Q000008:administration & dosage / Q000493:pharmacokinetics*
chemical_list: D000464:Alginates; D000994:Antitrichomonal Agents; D003692:Delayed-Action Preparations; D004337:Drug Carriers; D006603:Hexuronic Acids; D015609:Organotechnetium Compounds; D019275:Radiopharmaceuticals; D014011:Tinidazole; D020723:Glucuronic Acid; D048271:Chitosan