title: Adiponectin, leptin, resistin and insulin blood concentrations in patients with ischaemic cerebral stroke.
abstract: BACKGROUND
  Stroke, due to its worldwide prevalence, is not only a medical challenge, but also a serious social problem. Recently, ongoing research has examined whether there are associations between adipose tissue hormones and the risk, mechanisms and course of stroke. The aim of our study was to determine whether there are significant differences in blood concentrations of insulin, adiponectin, leptin, resistin and in insulin resistance among patients in the acute phase of ischaemic stroke, compared to healthy subjects. In addition, we wanted to investigate if those biochemical values show a correlation with the neurological condition of our patients.
  
  
  METHODS
  Adiponectin, leptin, resistin and insulin were measured in patients (n = 69) with first-ever ischaemic stroke (confirmed by CT), using specific electrochemoluminescence, radioimmunoassay and ELISA methods. Neurological evaluation was performed using Barthel ADL index on the day of admission and on the ninth day of hospitalisation. Insulin resistance value was obtained via the HOMA-IR calculator. Data was compared to that of healthy individuals (n = 26).
  
  
  RESULTS
  Insulin concentration (51.08 v. 17.02 uU/mL) and HOMA-IR value (6.3 v. 2.2) were significantly higher in the study group. Leptin (14.98 v. 10.47 ng/mL) and resistin (28.92 v. 12.25 ng/mL) levels were elevated among the stroke survivors compared to controls, but no significant difference was noted in adiponectin. Negative correlations of adiponectin level and Barthel score were observed.
  
  
  CONCLUSIONS
  Hyperinsulinaemia and insulin resistance are involved in the pathogenesis of ischaemic stroke. Hyperleptinaemia and hyperresistinaemia play a role in the mechanism of stroke. The severity of stroke is associated with adiponectin blood concentration.
authors.affiliation: Department of Neurology, Voivodeship Specialistic Hospital No 3, Rybnik, Poland.
authors.forename: Radosław
authors.initials: R
authors.lastname: Bienek
authors.forename: Bogdan
authors.initials: B
authors.lastname: Marek
authors.forename: Dariusz
authors.initials: D
authors.lastname: Kajdaniuk
authors.forename: Halina
authors.initials: H
authors.lastname: Borgiel-Marek
authors.forename: Tomasz
authors.initials: T
authors.lastname: Piecha
authors.forename: Mariusz
authors.initials: M
authors.lastname: Nowak
authors.forename: Lucyna
authors.initials: L
authors.lastname: Siemińska
authors.forename: Joanna
authors.initials: J
authors.lastname: Głogowska-Szeląg
authors.forename: Wanda
authors.initials: W
authors.lastname: Foltyn
authors.forename: Beata
authors.initials: B
authors.lastname: Kos-Kudła
mesh_terms: D052242:Adiponectin / Q000097:blood*; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015415:Biomarkers / Q000097:blood; D005260:Female; D006706:Homeostasis; D006801:Humans; D007328:Insulin / Q000097:blood*; D020738:Leptin / Q000097:blood*; D008297:Male; D008875:Middle Aged; D011044:Poland; D052243:Resistin / Q000097:blood*; D020521:Stroke / Q000097:blood*
chemical_list: D052242:Adiponectin; D015415:Biomarkers; D007328:Insulin; D020738:Leptin; D052243:Resistin