title: CD45/CD8 Myeloid Histioid Antigen and Plasma Cell Antibody Immune Response in a Case of Malignant Melanoma.
abstract: The immune response in metastatic melanoma is not well established and therefore is of particular interest to test for recruitment of immune cells to the tumor. A 46-year-old Caucasian female was evaluated for an asymptomatic right forearm mass. The lesion had been present for at least 4 years and had become painful 4 months ago. Biopsies for hematoxylin and eosin (H and E) staining, as well as immunohistochemical analysis were performed on the primary tumor and on sentinel lymph nodes. The H and E staining was consistent with metastatic melanoma. Positive staining was noted on the tumor cells with S-100, Mart-1/Melan A/CD63, PNL2, HMB45, and tyrosinase. Peritumoral and intratumoral inflammatory cells stained positive for CD8, CD45, PCNA, myeloid histoid antigen, antihuman plasma cell antibody, and focal BRCA1. The staining patterns of CD8/CD45, myeloid histoid antigen and plasma cell antibody on inflammatory cells around the melanoma cells suggest an unusual type of immune response.
authors.affiliation: Georgia Dermatopathology Associates, Atlanta, USA.
authors.forename: Ana Maria
authors.initials: AM
authors.lastname: Abreu-Velez
authors.forename: Michael S
authors.initials: MS
authors.lastname: Howard
authors.forename: Neville Y
authors.initials: NY
authors.lastname: Pereyo
authors.forename: Keith A
authors.initials: KA
authors.lastname: Delman
authors.forename: Martin C
authors.initials: MC
authors.lastname: Mihm
authors.forename: Monica
authors.initials: M
authors.lastname: Rizzo
keywords: CD45; CD8; Immune response; Metastatic melanoma; Myeloid histiod antigen; Plasma cell antibody