title: CENP-A: the key player behind centromere identity, propagation, and kinetochore assembly.
abstract: Chromosome segregation is the one of the great problems in biology with complexities spanning from biophysics and polymer dynamics to epigenetics. Here, we summarize the current knowledge and highlight gaps in understanding of the mechanisms controlling epigenetic regulation of chromosome segregation.
authors.affiliation: Institute for Research in Immunology and Cancer (IRIC), Department of Pathology and Cell Biology, Université de Montréal, C.P. 6128, Succursale Centre-ville, Montréal, Québec H3C 3J7, Canada. valerie.de.rop@umontreal.ca
authors.forename: Valérie
authors.initials: V
authors.lastname: De Rop
authors.forename: Abbas
authors.initials: A
authors.lastname: Padeganeh
authors.forename: Paul S
authors.initials: PS
authors.lastname: Maddox
mesh_terms: D000818:Animals; D001324:Autoantigens / Q000502:physiology*; D002503:Centromere / Q000235:genetics / Q000378:metabolism*; D000076247:Centromere Protein A; D002843:Chromatin / Q000235:genetics / Q000378:metabolism; D002868:Chromosomal Proteins, Non-Histone / Q000502:physiology*; D020090:Chromosome Segregation; D044127:Epigenesis, Genetic; D006801:Humans; D018386:Kinetochores / Q000378:metabolism*; D008938:Mitosis; D009369:Neoplasms / Q000235:genetics; D009707:Nucleosomes / Q000235:genetics / Q000378:metabolism; D011499:Protein Processing, Post-Translational
chemical_list: D001324:Autoantigens; C000619700:CENPA protein, human; D000076247:Centromere Protein A; D002843:Chromatin; D002868:Chromosomal Proteins, Non-Histone; D009707:Nucleosomes