title: Use of hemoglobin A1C to detect Haitian-Americans with undiagnosed Type 2 diabetes.
abstract: OBJECTIVE
  To evaluate the validity of hemoglobin A1C (A1C) as a diagnostic tool for type 2 diabetes and to determine the most appropriate A1C cutoff point for diagnosis in a sample of Haitian-Americans.
  
  
  METHODS
  Subjects (n = 128) were recruited from Miami-Dade and Broward counties, FL. Receiver operating characteristics (ROC) analysis was run in order to measure sensitivity and specificity of A1C for detecting diabetes at different cutoff points.
  
  
  RESULTS
  The area under the ROC curve was 0.86 using fasting plasma glucose ≥ 7.0 mmol/L as the gold standard. An A1C cutoff point of 6.26% had sensitivity of 80% and specificity of 74%, whereas an A1C cutoff point of 6.50% (recommended by the American Diabetes Association - ADA) had sensitivity of 73% and specificity of 89%.
  
  
  CONCLUSIONS
  A1C is a reliable alternative to fasting plasma glucose in detecting diabetes in this sample of Haitian-Americans. A cutoff point of 6.26% was the optimum value to detect type 2 diabetes.
authors.affiliation: Department of Dietetics and Nutrition, Florida International University, Miami, FL, United States.
authors.forename: Joel C
authors.initials: JC
authors.lastname: Exebio
authors.forename: Gustavo G
authors.initials: GG
authors.lastname: Zarini
authors.forename: Joan A
authors.initials: JA
authors.lastname: Vaccaro
authors.forename: Cristobal
authors.initials: C
authors.lastname: Exebio
authors.forename: Fatma G
authors.initials: FG
authors.lastname: Huffman
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000097:blood; D001786:Blood Glucose / Q000032:analysis*; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000175:diagnosis* / Q000208:ethnology; D005215:Fasting / Q000097:blood; D005260:Female; D005951:Glucose Tolerance Test; D006442:Glycated Hemoglobin / Q000032:analysis*; D006205:Haiti / Q000208:ethnology; D006801:Humans; D008297:Male; D012372:ROC Curve; D012680:Sensitivity and Specificity; D014481:United States
chemical_list: D015415:Biomarkers; D001786:Blood Glucose; D006442:Glycated Hemoglobin; C517652:hemoglobin A1c protein, human