title: Bone mineral density increases in HIV-infected children treated with long-term combination antiretroviral therapy.
abstract: The long-term treatment of human immunodeficiency virus (HIV)-infected children with combination antiretroviral therapy (cART) requires assessment of potential adverse effects, such as osteoporosis. Longitudinal data on bone mineral density (BMD) in HIV-infected children showed that cumulative treatment with cART had a positive impact on BMD over time.
authors.affiliation: Department of Paediatric Immunology, Haematology, and Infectious Diseases, Emma Children Hospital, Amsterdam, The Netherlands. m.j.bunders@amc.uva.nl
authors.forename: Madeleine J
authors.initials: MJ
authors.lastname: Bunders
authors.forename: Olivier
authors.initials: O
authors.lastname: Frinking
authors.forename: Henriette J
authors.initials: HJ
authors.lastname: Scherpbier
authors.forename: Lotus A
authors.initials: LA
authors.lastname: van Arnhem
authors.forename: Berthe L
authors.initials: BL
authors.lastname: van Eck-Smit
authors.forename: Taco W
authors.initials: TW
authors.lastname: Kuijpers
authors.forename: Aeilko H
authors.initials: AH
authors.lastname: Zwinderman
authors.forename: Peter
authors.initials: P
authors.lastname: Reiss
authors.forename: Dasja
authors.initials: D
authors.lastname: Pajkrt
mesh_terms: D023241:Antiretroviral Therapy, Highly Active / Q000009:adverse effects*; D015519:Bone Density / Q000187:drug effects*; D002648:Child; D002675:Child, Preschool; D005260:Female; D015658:HIV Infections / Q000188:drug therapy*; D006801:Humans; D008297:Male; D010024:Osteoporosis / Q000139:chemically induced*; D012044:Regression Analysis; D013997:Time Factors