title: Novel transformation of α,β-unsaturated aldehydes and ketones into γ-amino alcohols or 1,3-oxazines via a 4 or 5 step, one-pot sequence.
abstract: An efficient, 4-step, one-pot, highly stereoselective route to γ-amino alcohols has been developed via an in situ α,β-unsaturated imine formation, β-boration, reduction (C=N) and oxidation (C-B) sequence and especially for certain water-soluble γ-amino alcohols, a further step can be added to directly access the corresponding 1,3-oxazine derivatives.
authors.affiliation: Centre for Sustainable Chemical Processes, Dept. of Chemistry, Durham University, UK.
authors.forename: Adam D J
authors.initials: AD
authors.lastname: Calow
authors.forename: Andrei S
authors.initials: AS
authors.lastname: Batsanov
authors.forename: Elena
authors.initials: E
authors.lastname: Fernández
authors.forename: Cristina
authors.initials: C
authors.lastname: Solé
authors.forename: Andrew
authors.initials: A
authors.lastname: Whiting