title: Biology and therapeutic potential of hydrogen sulfide and hydrogen sulfide-releasing chimeras.
abstract: Hydrogen sulfide, H2S, is a colorless gas with a strong odor that until recently was only considered to be a toxic environmental pollutant with little or no physiological significance. However, the past few years have demonstrated its role in many biological systems and it is becoming increasingly clear that H2S is likely to join nitric oxide (NO) and carbon monoxide (CO) as a major player in mammalian biology. In this review, we have provided an overview of the chemistry and biology of H2S and have summarized the chemistry and biological activity of some natural and synthetic H2S-donating compounds. The naturally occurring compounds discussed include, garlic, sulforaphane, erucin, and iberin. The synthetic H2S donors reviewed include, GYY4137; cysteine analogs; S-propyl cysteine, S-allyl cysteine, S-propargyl cysteine, and N-acetyl cysteine. Dithiolethione and its NSAID and other chimeras such as, L-DOPA, sildenafil, aspirin, diclofenac, naproxen, ibuprofen, indomethacin, and mesalamine have also been reviewed in detail. The newly reported NOSH-aspirin that releases both NO and H2S has also been discussed.
authors.affiliation: Department of Physiology and Pharmacology, Sophie Davis School of Biomedical Education, City University of New York Medical School, 138th Street and Convent Avenue, New York, NY 10031, United States. Electronic address: kashfi@med.cuny.edu.
authors.forename: Khosrow
authors.initials: K
authors.lastname: Kashfi
authors.affiliation: Department of Physiology, Indiana University School of Medicine, 1234 Notre Dame Avenue, South Bend, IN 46617, United States. Electronic address: olson.1@nd.edu.
authors.forename: Kenneth R
authors.initials: KR
authors.lastname: Olson
mesh_terms: D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000737:chemistry / Q000494:pharmacology; D018890:Chemoprevention; D002678:Chimera / Q000378:metabolism*; D006801:Humans; D006862:Hydrogen Sulfide / Q000737:chemistry* / Q000494:pharmacology*; D009369:Neoplasms / Q000517:prevention & control
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D006862:Hydrogen Sulfide