title: Oxidative stress and interleukin-6 secretion during the progression of type 1 diabetes.
abstract: OBJECTIVE
  To evaluate inflammatory, oxidizing, and reducing responses during the progression of type 1 diabetes mellitus (T1DM) in patients without chronic complications.
  
  
  METHODS
  Plasma antioxidant status, reactive oxygen species (ROS), and interleukin-6 (IL-6) were measured in 42 patients with T1DM and in 24 healthy subjects.
  
  
  RESULTS
  Significant increases were detected in the median values of ROS and IL-6 in patients with T1DM compared with healthy subjects (ROS ~ 4,836 vs. 2,036 RLU/min, respectively; P < .05: IL-6 ~ 14.2 vs. 9.7 pg/mL, respectively; P = .002). No significant between-group differences (P > 0.05) were observed in oxidizing responses or in IL-6 concentrations when diabetic patients were grouped according to time after diagnosis (0 - 10, 10 - 20 and > 20 years). Plasma antioxidant responses were similar in patients with T1DM and in healthy subjects.
  
  
  CONCLUSIONS
  Our results demonstrate that oxidizing and inflammatory responses are increased at the onset of T1DM, but remain unchanged during disease progression. These findings suggest that functional changes involved in diabetic complications may commence in the first years after diagnosis.
authors.affiliation: Núcleo de Pesquisa e Pós-Graduação, Hospital Santa Casa de Belo Horizonte, Belo Horizonte, MG, Brazil.
authors.forename: Janice Sepúlveda
authors.initials: JS
authors.lastname: Reis
authors.forename: Clara Araújo Veloso
authors.initials: CA
authors.lastname: Amaral
authors.forename: Caroline Maria Oliveira
authors.initials: CM
authors.lastname: Volpe
authors.forename: Jamille Silveira
authors.initials: JS
authors.lastname: Fernandes
authors.forename: Erica Abreu
authors.initials: EA
authors.lastname: Borges
authors.forename: Camila Armond
authors.initials: CA
authors.lastname: Isoni
authors.forename: Paula Martins Ferreira Dos
authors.initials: PM
authors.lastname: Anjos
authors.forename: José Augusto Nogueira
authors.initials: JA
authors.lastname: Machado
mesh_terms: D000368:Aged; D016022:Case-Control Studies; D003922:Diabetes Mellitus, Type 1 / Q000097:blood* / Q000503:physiopathology; D018450:Disease Progression; D005260:Female; D006801:Humans; D015850:Interleukin-6 / Q000097:blood / Q000378:metabolism*; D008297:Male; D018384:Oxidative Stress / Q000502:physiology*; D017382:Reactive Oxygen Species / Q000097:blood*
chemical_list: D015850:Interleukin-6; D017382:Reactive Oxygen Species