title: Preliminary studies on serum lipids, apolipoprotein-B and oxidative stress in xanthelasma.
abstract: Serum lipid profile, apolipoprotein-B (apo-B), malondialdehyde levels(MDA) and superoxide dismutase (SOD) activity were assessed in 12 cases of xanthelasma with and without coronary artery disease (CAD)/hypertension (HTN) and results are compared with healthy controls. Dyslipidemia was found in 65% cases of xanthelasma as compared to 20% healthy controls. Xanthelasma patients had significantly high malondialdehyde (MDA) levels (p<0.01) and significantly decreased (p<0.05) SOD activity as compared to controls. Among xanthelasma patients, xanthelasma with CAD/HTN showed higher total cholesterol (236±32.7 vs 188±24.7 mg/dl), low density lipoprotein cholesterol (157±35.5 vs 113±16 mg/dl) and Apo-B (120.5±9.4 vs 114±19.2 mg/dl) levels as compared to xanthelasma without CAD/HTN. Results of our study indicate that xanthelasma patients with increased apo-B, MDA and decreased SOD need cardiovascular monitoring.
authors.affiliation: Department of Biochemistry, University College of Medical Sciences and G.T.B. Hospital, 110 095 Delhi.
authors.forename: S B
authors.initials: SB
authors.lastname: Sharma
authors.forename: S
authors.initials: S
authors.lastname: Dwivedi
authors.forename: K M
authors.initials: KM
authors.lastname: Prabhu
authors.forename: N
authors.initials: N
authors.lastname: Kumar
authors.forename: M C
authors.initials: MC
authors.lastname: Baruah
keywords: Xanthelasma; apolipoprotein B; coronary artery disease; malondialdehyde; superoxide dismutase