title: Body mass index, height and risk of lymphoid neoplasms in a large United States cohort.
abstract: Results from epidemiologic studies examining associations between body size and risk of non-Hodgkin lymphoma (NHL) are inconsistent, and etiology may vary by histologic subtype of disease. Using Cox proportional hazards regression, multivariable relative risks (RRs) and 95% confidence intervals (CIs) were computed for associations of body mass index (BMI) and height with NHL in the prospective American Cancer Society Cancer Prevention Study-II Nutrition Cohort. From 1992 to 2007, 2074 incident cases of NHL were identified among 152 423 men and women. Obese individuals (BMI ≥ 30 kg/m(2)) had 23% higher incidence of NHL (95% CI 1.08-1.40) compared to those with normal weight (BMI 18.5-< 25 kg/m(2)). Height was positively associated with NHL (RR = 1.25, 95% CI 1.10-1.43, sex-specific quintile 5 vs. 1). BMI associations were strongest for diffuse large B-cell lymphoma. Height was most strongly associated with chronic lymphocytic leukemia/small lymphocytic lymphoma and to a lesser extent with multiple myeloma. These findings provide further evidence that body size may play a role in the etiology of NHL, which is of public health importance given the rapid rise in obesity worldwide.
authors.affiliation: Epidemiology Research Program, American Cancer Society, Atlanta, GA, USA. apatel@cancer.org
authors.forename: Alpa V
authors.initials: AV
authors.lastname: Patel
authors.forename: W Ryan
authors.initials: WR
authors.lastname: Diver
authors.forename: Lauren R
authors.initials: LR
authors.lastname: Teras
authors.forename: Brenda M
authors.initials: BM
authors.lastname: Birmann
authors.forename: Susan M
authors.initials: SM
authors.lastname: Gapstur
mesh_terms: D000293:Adolescent; D000328:Adult; D001827:Body Height; D015992:Body Mass Index; D005260:Female; D006801:Humans; D008228:Lymphoma, Non-Hodgkin / Q000453:epidemiology* / Q000209:etiology* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D012306:Risk; D014481:United States / Q000453:epidemiology; D055815:Young Adult