title: Protective effect of anthocyanin from Lonicera Caerulea var. Edulis on radiation-induced damage in mice.
abstract: The radioprotective effect of anthocyanin extracted from Lonicera caerulea var. edulis (ALC), was studied in ICR mice. Different doses of ALC were intragastrically administered to mice once a day, prior to radiation. After two weeks, the mice received a one-time 5 Gy whole body (60)Coγ radiation. The spleen index, thymus index, activities of superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px), malondialdehyde (MDA) content, and glutathione (GSH) content in liver tissue were measured. Compared with the radiation control group, the levels of MDA in all ALC treated groups decreased significantly (p < 0.05). Moreover, the GSH content, activities of SOD and GSH-Px in liver tissue were enhanced significantly (p < 0.05) in all ALC groups. These results demonstrate that ALC may be a potential radioprotector, and a further study of the molecular mechanism is needed for further application.
authors.affiliation: School of Food Science and Engineering, Harbin Institute of Technology, Harbin 150090, China.
authors.forename: Haitian
authors.initials: H
authors.lastname: Zhao
authors.affiliation: School of Food Science and Engineering, Harbin Institute of Technology, Harbin 150090, China.|School of Forestry, Northeast Forestry University, Harbin 150040, China.
authors.forename: Zhenyu
authors.initials: Z
authors.lastname: Wang
authors.affiliation: School of Food Science and Engineering, Harbin Institute of Technology, Harbin 150090, China.|School of Forestry, Northeast Forestry University, Harbin 150040, China.
authors.forename: Fengming
authors.initials: F
authors.lastname: Ma
authors.affiliation: School of Food Science and Engineering, Harbin Institute of Technology, Harbin 150090, China.
authors.forename: Xin
authors.initials: X
authors.lastname: Yang
authors.affiliation: School of Food Science and Engineering, Harbin Institute of Technology, Harbin 150090, China.
authors.forename: Cuilin
authors.initials: C
authors.lastname: Cheng
authors.affiliation: School of Food Science and Engineering, Harbin Institute of Technology, Harbin 150090, China.|National Research Center of Soybean Engineering and Technology, Northeast Agriculture University, Harbin 150030, China.
authors.forename: Lei
authors.initials: L
authors.lastname: Yao
mesh_terms: D000818:Animals; D000872:Anthocyanins / Q000737:chemistry / Q000494:pharmacology*; D005720:Gamma Rays / Q000009:adverse effects*; D005979:Glutathione Peroxidase / Q000378:metabolism; D008099:Liver / Q000378:metabolism / Q000473:pathology; D031239:Lonicera / Q000737:chemistry*; D008315:Malondialdehyde / Q000378:metabolism; D051379:Mice; D008813:Mice, Inbred ICR; D011833:Radiation Injuries, Experimental / Q000378:metabolism / Q000473:pathology / Q000517:prevention & control*; D011837:Radiation-Protective Agents / Q000737:chemistry / Q000494:pharmacology*; D013154:Spleen / Q000378:metabolism / Q000473:pathology; D013482:Superoxide Dismutase / Q000378:metabolism; D013950:Thymus Gland / Q000378:metabolism / Q000473:pathology; D014916:Whole-Body Irradiation
chemical_list: D000872:Anthocyanins; D011837:Radiation-Protective Agents; D008315:Malondialdehyde; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase
keywords: 60Coγ radiation; Lonicera caerulea var. edulis; anthocyanin; mice; radioprotection