title: Circulating levels of cell adhesion molecules in hypertension.
abstract: Hypertension causes complications such as coronary atherosclerosis and thrombosis wherein inflammatory factors play significant role. In the present study inflammatory molecules such as cell adhesion molecules (CAMs); endothelial (E)-selectin, platelet (P)-selectin, intercellular CAM-1 (ICAM-1), vascular CAM-1 (VCAM-1) and platelet endothelial CAM-1 (PECAM-1) were analysed in subjects newly diagnosed with hypertension with no secondary cause against normotensive healthy individuals. In each group 57 subjects were recruited and soluble (s) levels of CAMs were analysed by ELISA. As compared to controls median of sE-selectin (49.2%, P=0.001), sP-selectin (54.3%, P=0.001), and sICAM-1 (18.9%, P=0.012) were significantly elevated in hypertensive subjects. Significant negative correlation was observed of sP-selectin (spearman rank correlation coefficient (rs) =-0.345, p=0.027) and sPECAM-1 (rs =-0.446, p=0.003) with age in hypertension group. Hypertension may increase expression of certain CAMs while younger hypertensives in addition are also at increased risk of atherothrombosis.
authors.affiliation: Sir H. N. Medical Research Society, Sir H. N. Hospital and Research Centre, Raja Rammohan Roy Road, Mumbai, 400 004 India.
authors.forename: Kavita K
authors.initials: KK
authors.lastname: Shalia
authors.forename: Manoj R
authors.initials: MR
authors.lastname: Mashru
authors.forename: Jagdish B
authors.initials: JB
authors.lastname: Vasvani
authors.forename: Rajashree A
authors.initials: RA
authors.lastname: Mokal
authors.forename: Shilpa M
authors.initials: SM
authors.lastname: Mithbawkar
authors.forename: Priti K
authors.initials: PK
authors.lastname: Thakur
keywords: Cell adhesion molecules; Hypertension; ICAM-1; PECAM-1; Selectins; VCAM-1