title: Mechanisms of the anti-inflammatory and antifibrotic activity of a sympatholytic agent during toxic pulmonary fibrosis.
abstract: The effect of a course treatment with a sympatholytic reserpine on the inflammatory response and connective tissue proliferation in the lungs of C57Bl/6 mice was studied on the model of toxic pulmonary fibrosis induced by intratracheal administration of bleomycin. This sympatholytic reduced infiltration of the alveolar interstitium and alveolar ducts with inflammatory cells (lymphocytes, macrophages, neutrophils, and plasma cells) and prevented connective tissue proliferation in the lungs. The anti-inflammatory effect of reserpine was associated with a decrease in activity of bone marrow granulocyte-erythroid-macrophage-megakaryocyte and granulocyte precursors (proliferation and mobilization). The antifibrotic effect of reserpine was due to a decrease in the number of committed precursors for mesenchymopoiesis.
authors.affiliation: Institute of Pharmacology, Tomsk Research Center, Siberian Division of the Russian Academy of Medical Sciences, Tomsk, Russia. ovpershina@gmail.com
authors.forename: E G
authors.initials: EG
authors.lastname: Skurikhin
authors.forename: E S
authors.initials: ES
authors.lastname: Khmelevskaya
authors.forename: O V
authors.initials: OV
authors.lastname: Pershina
authors.forename: T V
authors.initials: TV
authors.lastname: Andreeva
authors.forename: L A
authors.initials: LA
authors.lastname: Ermolaeva
authors.forename: V A
authors.initials: VA
authors.lastname: Krupin
authors.forename: N N
authors.initials: NN
authors.lastname: Ermakova
authors.forename: A M
authors.initials: AM
authors.lastname: Reztsova
authors.forename: I E
authors.initials: IE
authors.lastname: Stepanova
authors.forename: A M
authors.initials: AM
authors.lastname: Dygai
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology* / Q000627:therapeutic use; D001761:Bleomycin / Q000633:toxicity*; D003114:Colony-Forming Units Assay; D055014:Granulocyte-Macrophage Progenitor Cells / Q000187:drug effects; D006652:Histological Techniques; D051379:Mice; D008810:Mice, Inbred C57BL; D020556:Neutrophil Infiltration / Q000187:drug effects; D011650:Pulmonary Alveoli / Q000187:drug effects* / Q000276:immunology; D011658:Pulmonary Fibrosis / Q000139:chemically induced* / Q000188:drug therapy*; D012110:Reserpine / Q000494:pharmacology* / Q000627:therapeutic use; D018709:Statistics, Nonparametric; D013565:Sympatholytics / Q000494:pharmacology* / Q000627:therapeutic use
chemical_list: D000893:Anti-Inflammatory Agents; D013565:Sympatholytics; D001761:Bleomycin; D012110:Reserpine