title: Cannabidiol for the treatment of cannabis withdrawal syndrome: a case report.
abstract: OBJECTIVE
  Cannabis withdrawal in heavy users is commonly followed by increased anxiety, insomnia, loss of appetite, migraine, irritability, restlessness and other physical and psychological signs. Tolerance to cannabis and cannabis withdrawal symptoms are believed to be the result of the desensitization of CB1 receptors by THC.
  
  
  METHODS
  This report describes the case of a 19-year-old woman with cannabis withdrawal syndrome treated with cannabidiol (CBD) for 10 days. Daily symptom assessments demonstrated the absence of significant withdrawal, anxiety and dissociative symptoms during the treatment.
  
  
  CONCLUSIONS
  CBD can be effective for the treatment of cannabis withdrawal syndrome.
authors.affiliation: Department of Neuroscience and Behavior, Ribeirão Preto Medical School, University of São Paulo and INCT Translational Medicine (CNPq)-São Paulo, Brazil. jcrippa@fmrp.usp.br
authors.forename: J A S
authors.initials: JA
authors.lastname: Crippa
authors.forename: J E C
authors.initials: JE
authors.lastname: Hallak
authors.forename: J P
authors.initials: JP
authors.lastname: Machado-de-Sousa
authors.forename: R H C
authors.initials: RH
authors.lastname: Queiroz
authors.forename: M
authors.initials: M
authors.lastname: Bergamaschi
authors.forename: M H N
authors.initials: MH
authors.lastname: Chagas
authors.forename: A W
authors.initials: AW
authors.lastname: Zuardi
mesh_terms: D000328:Adult; D002185:Cannabidiol / Q000627:therapeutic use*; D002188:Cannabis / Q000009:adverse effects*; D005260:Female; D006801:Humans; D013375:Substance Withdrawal Syndrome / Q000188:drug therapy*; D055815:Young Adult
chemical_list: D002185:Cannabidiol