title: Microautophagy in the visceral endoderm is essential for mouse early development.
abstract: During early embryogenesis, before the conceptus forms the placenta, maternal nutrients as well as signaling molecules must reach the embryo proper through a tightly sealed epithelial tissue, the visceral endoderm (VE). The VE serves as a signaling center for embryogenesis, where exocytic and endocytic processes integrate signal production, perception and termination. However, the endocytic process in this important tissue has not been well characterized. We show that endocytic delivery to the lysosomes occurs via RAB7-dependent microautophagy. This process is essential for early mammalian development.
authors.affiliation: Division of Biological Science, Institute for Scientific and Industrial Research, Osaka University, Ibaraki, Osaka, Japan. yohwada@sanken.osaka-u.ac.jp
authors.forename: Yoh
authors.initials: Y
authors.lastname: Wada
authors.forename: Ge-Hong
authors.initials: GH
authors.lastname: Sun-Wada
authors.forename: Nobuyuki
authors.initials: N
authors.lastname: Kawamura
mesh_terms: D000818:Animals; D001343:Autophagy; D047108:Embryonic Development; D004707:Endoderm / Q000166:cytology* / Q000196:embryology* / Q000378:metabolism; D011992:Endosomes / Q000378:metabolism; D008247:Lysosomes / Q000378:metabolism; D051379:Mice; D008954:Models, Biological; D014781:Viscera / Q000196:embryology*; D020691:rab GTP-Binding Proteins / Q000378:metabolism
chemical_list: D020691:rab GTP-Binding Proteins
keywords: RAB7; apical vacuole; autophagy; early mouse development; microautophagy