title: Systemic or intrasynovial medication as singular or as combination treatment in horses with (peri-)synovial pain.
abstract: Records of lame horses (2004-2007) with (peri-)synovial pain of the metacarpophalangeal joint (MCPJ, n = 53), digital flexor tendon sheath (DFTS, n = 20), and distal interphalangeal joint (DIPJ, n = 31) were evaluated (n = 104). Cases were grouped according to the following treatments: (1) systemic administration of NSAIDs (n = 40); (2) intrasynovial administration of glucocorticosteroids (n = 30); (3) combination treatment (n = 34). Outcome was defined as successful when the owner reported that the horse had returned to its previous level of performance within a period of up to six months after treatment. Statistical evaluation was performed using Fisher's Exact tests and multivariable logistic regression analyses at P < 0.05. Successful outcome was significantly higher for horses in treatment group 3 (19/34, 55.9 per cent, P = 0.021) than in treatment groups 1 (11/40, 27.5 per cent, OR 0.21, 95 per cent CI 0.06 to 0.71) and 2 (8/30, 26.6 per cent, OR 0.18, 95 per cent CI 0.06 to 0.56). A significant association was only found with regard to the affected synovial structure (P = 0.025); relative to the DIPJ, involvement of the MCPJ and DFTS was four to five times more likely to provide a successful outcome (OR 4.18 and 5.59, 95 per cent CI 1.24 to 14.08 and 1.42-22.22, respectively).
authors.affiliation: Department of Equine Sciences, Faculty of Veterinary Medicine, University of Utrecht, Yalelaan 112-114, Utrecht NL-3584 CM, The Netherlands. H.Brommer@uu.nl
authors.forename: H
authors.initials: H
authors.lastname: Brommer
authors.forename: P
authors.initials: P
authors.lastname: Schipper
authors.forename: A
authors.initials: A
authors.lastname: Barneveld
authors.forename: P R
authors.initials: PR
authors.lastname: van Weeren
mesh_terms: D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage / Q000627:therapeutic use*; D004333:Drug Administration Routes / Q000662:veterinary; D004359:Drug Therapy, Combination / Q000662:veterinary; D005260:Female; D005938:Glucocorticoids / Q000008:administration & dosage / Q000627:therapeutic use*; D006734:Horse Diseases / Q000188:drug therapy*; D006736:Horses; D007794:Lameness, Animal / Q000188:drug therapy*; D008297:Male; D010146:Pain / Q000188:drug therapy / Q000662:veterinary*; D012189:Retrospective Studies; D016896:Treatment Outcome
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D005938:Glucocorticoids