title: Synthesis of some novel 1-(2-naphthyl)-2-(imidazol-1-yl)ethanone oxime ester derivatives and evaluation of their anticonvulsant activity.
abstract: Twenty-three new oxime ester derivatives of nafimidone were synthesized with the prospect of potential anticonvulsant activities. MES and ScM tests were employed for their anticonvulsant activities and rotorod test for neurological deficits. Eighteen compounds were found to be protective against MES seizures. Alkyl (1-8) and arylalkyl (9, 10) oxime ester derivatives were found to be more active than aryl oxime ester derivatives (11-23). Five compounds (2, 3, 7, 9, 10), which were protective at 0.5 h at the doses of 30 mg/kg and higher in MES test, showed the highest activity. Compound 17 was the most active one in ScM test at all dose levels at 4 h.
authors.affiliation: Inonu University, Faculty of Pharmacy, Department of Pharmaceutical Chemistry, 44280 Malatya, Turkey. arzukarakurt@hotmail.com
authors.forename: Arzu
authors.initials: A
authors.lastname: Karakurt
authors.forename: Mehmet A
authors.initials: MA
authors.lastname: Alagöz
authors.forename: Burcu
authors.initials: B
authors.lastname: Sayoğlu
authors.forename: Unsal
authors.initials: U
authors.lastname: Calış
authors.forename: Sevim
authors.initials: S
authors.lastname: Dalkara
mesh_terms: D000818:Animals; D000927:Anticonvulsants / Q000138:chemical synthesis* / Q000494:pharmacology; D004597:Electroshock; D004952:Esters; D007093:Imidazoles / Q000138:chemical synthesis* / Q000494:pharmacology; D007536:Isomerism; D051379:Mice; D009043:Motor Activity / Q000187:drug effects; D009278:Naphazoline / Q000031:analogs & derivatives* / Q000737:chemistry / Q000494:pharmacology; D009483:Neuropsychological Tests; D010091:Oximes / Q000138:chemical synthesis* / Q000494:pharmacology; D012640:Seizures / Q000503:physiopathology / Q000517:prevention & control*; D013329:Structure-Activity Relationship
chemical_list: D000927:Anticonvulsants; D004952:Esters; D007093:Imidazoles; D010091:Oximes; D009278:Naphazoline; C038671:nafimidone