title: Concordance between HIV-2 genotypic coreceptor tropism predictions based on plasma RNA and proviral DNA.
abstract: In this study, assessing HIV-2 tropism among 43 paired plasma/peripheral blood mononuclear cell specimens, the concordance between proviral DNA and plasma RNA genotypic tropism prediction was 74%. All the discordances were attributable to the prediction of R5 in RNA and X4/dual-mixed in DNA. HIV-2 genotypic tropism test based on proviral DNA is a suitable tool for tropism determination in HIV-2-infected patients with low or undetectable viral load.
authors.affiliation: Laboratoire de Virologie, Assistance Publique-Hôpitaux de Paris AP-HP, Groupe Hospitalier Bichat-Claude Bernard, HUPNVS, Université Paris Diderot, Paris 7, PRES Sorbonne Paris Cité, Paris, France. benoit.visseaux@bch.aphp.fr
authors.forename: Benoit
authors.initials: B
authors.lastname: Visseaux
authors.forename: Charlotte
authors.initials: C
authors.lastname: Charpentier
authors.forename: Audrey
authors.initials: A
authors.lastname: Taieb
authors.forename: Florence
authors.initials: F
authors.lastname: Damond
authors.forename: Antoine
authors.initials: A
authors.lastname: Bénard
authors.forename: Lucile
authors.initials: L
authors.lastname: Larrouy
authors.forename: Geneviève
authors.initials: G
authors.lastname: Chêne
authors.forename: Françoise
authors.initials: F
authors.lastname: Brun-Vézinet
authors.forename: Sophie
authors.initials: S
authors.lastname: Matheron
authors.forename: Diane
authors.initials: D
authors.lastname: Descamps
mesh_terms: D004279:DNA, Viral / Q000097:blood / Q000235:genetics; D005838:Genotype; D015658:HIV Infections / Q000097:blood / Q000235:genetics*; D015498:HIV-2 / Q000235:genetics*; D006801:Humans; D011237:Predictive Value of Tests; D012367:RNA, Viral / Q000097:blood / Q000235:genetics; D019562:Viral Load / Q000235:genetics; D056189:Viral Tropism / Q000235:genetics*
chemical_list: D004279:DNA, Viral; D012367:RNA, Viral