title: Oral submucous fibrosis: an overview of the aetiology, pathogenesis, classification, and principles of management.
abstract: Oral submucous fibrosis (OSMF) is a complex, debilitating, and precancerous condition. Formerly confined to the Indian subcontinent, it is now often seen in the Asian populations of the United Kingdom, USA, and other developed countries, and is therefore a serious problem for global health. The well-known causative agent of the disease, areca-nut is now recognised as a group one carcinogen. We review and discuss all components of OSMF, including the terminology, presentation, aetiology, and pathogenesis, and provide a brief overview of its management.
authors.affiliation: Department of Oral and Maxillofacial Surgery, Navodaya Dental College and Hospital, Raichur, Karnataka, India. Electronic address: gururaj.arakeri@gmail.com.
authors.forename: Gururaj
authors.initials: G
authors.lastname: Arakeri
authors.forename: Peter A
authors.initials: PA
authors.lastname: Brennan
mesh_terms: D001114:Areca / Q000009:adverse effects*; D006801:Humans; D009914:Oral Submucous Fibrosis / Q000209:etiology / Q000503:physiopathology / Q000628:therapy; D011230:Precancerous Conditions / Q000209:etiology*; D064424:Tobacco Use / Q000009:adverse effects; D014313:Trismus / Q000209:etiology
keywords: Aetiology; Areca-nut; Gutkha; Oral submucous fibrosis; Pathogenesis; Review