title: Vascular endothelial growth factor family gene polymorphisms in preeclampsia in Sinhalese women in Sri-Lanka.
abstract: OBJECTIVE
  To investigate the association of polymorphisms in the vascular endothelial growth factor (VEGF) family genes (VEGFA rs699947, VEGFA rs3025039, PGF rs1042886, KDR rs2071559 and KDR rs2305948) with preeclampsia in Sinhalese women in Sri-Lanka.
  
  
  METHODS
  We conducted a case-control study where 175 nulliparous Sinhalese women with preeclampsia and 171 normotensive women matched for age, ethnicity, parity and BMI were recruited in tertiary care maternity hospitals in Sri-Lanka. Preeclampsia was diagnosed using international guidelines. DNA extracted from peripheral venous blood and was genotyped using the Sequenom MassARRAY system. χ(2)-test was used to compare the distribution of allele and genotype frequencies between the cases and the control subjects.
  
  
  RESULTS
  The frequency of PGF rs1042886 variant allele (odds ratio (OR) 1.5, 95% confidence interval (CI) 1.1-2.1) and dominant genotype model (aOR 1.6, 95% CI 1.0-2.4) were increased in preeclamptic women compared to controls. VEGFA rs699947, VEGFA rs3025039, KDR rs2071559, and KDR rs2305948 polymorphisms were not associated with preeclampsia.
  
  
  CONCLUSIONS
  Maternal PGF rs1042886 polymorphism is associated with preeclampsia in Sinhalese women in Sri-Lanka.
authors.affiliation: Discipline of Obstetrics and Gynaecology, Robinson Institute, University of Adelaide, Adelaide, Australia.
authors.forename: Prabha H
authors.initials: PH
authors.lastname: Andraweera
authors.forename: Gustaaf A
authors.initials: GA
authors.lastname: Dekker
authors.forename: Vajira H W
authors.initials: VH
authors.lastname: Dissanayake
authors.forename: Tina
authors.initials: T
authors.lastname: Bianco-Miotto
authors.forename: Rohan W
authors.initials: RW
authors.lastname: Jayasekara
authors.forename: Claire T
authors.initials: CT
authors.lastname: Roberts
mesh_terms: D000328:Adult; D015992:Body Mass Index; D016022:Case-Control Studies; D004247:DNA / Q000097:blood; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D016017:Odds Ratio; D010298:Parity; D000072483:Placenta Growth Factor; D020641:Polymorphism, Single Nucleotide; D011225:Pre-Eclampsia / Q000208:ethnology / Q000235:genetics*; D011247:Pregnancy; D011257:Pregnancy Proteins / Q000235:genetics*; D013188:Sri Lanka; D042461:Vascular Endothelial Growth Factor A / Q000235:genetics*
chemical_list: C000608036:PGF protein, human; D011257:Pregnancy Proteins; D042461:Vascular Endothelial Growth Factor A; D000072483:Placenta Growth Factor; D004247:DNA