title: Effect of Helicobacter pylori eradication according to the IL-8-251 polymorphism in Koreans.
abstract: Previous studies suggested that polymorphisms of proinflammatory cytokine genes are important host genetic factors in Helicobacter pylori infection. The present study evaluated whether IL-8-251 polymorphism affected H. pylori eradication rate and to investigate the effect of H. pylori eradication on angiogenesis and the inflammatory process according to the IL-8-251 polymorphism. A total of 250 H. pylori-positive patients treated by endoscopic resection of the gastric neoplasm were classified into 3 groups (134 H. pylori-eradicated group, 19 H. pylori-eradication failure group, and 97 H. pylori-infected group). H. pylori status, histology, and angiogenic factor levels were evaluated at baseline, 6 months, and 18 months. H. pylori eradication rate was 92.9% in AA genotype, 85.7% in AT genotype and 88.4% in TT genotype (P value = 0.731). Elevated IL-8 and matrix metalloproteinase-9 concentrations in H. pylori-infected gastric mucosa were reversible by successful eradication of H. pylori, independent of the IL-8-251 polymorphism. It is suggested that elevated IL-8 and MMP-9 concentrations in H. pylori-infected gastric mucosa are altered significantly after successful eradication and these conditions continue for 18 months. However, IL-8-251 polymorphism does not affect H. pylori eradication rate and the sequential changes of related angiogenic factors after H. pylori eradication in Koreans.
authors.affiliation: Department of Internal Medicine and Healthcare Research Institute, Seoul National University Hospital Healthcare System Gangnam Center, Seoul, Korea.
authors.forename: Hae Yeon
authors.initials: HY
authors.lastname: Kang
authors.forename: Sang Gyun
authors.initials: SG
authors.lastname: Kim
authors.forename: Mi Kyung
authors.initials: MK
authors.lastname: Lee
authors.forename: Joo Sung
authors.initials: JS
authors.lastname: Kim
authors.forename: Hyun Chae
authors.initials: HC
authors.lastname: Jung
authors.forename: In Sung
authors.initials: IS
authors.lastname: Song
mesh_terms: D000368:Aged; D000483:Alleles; D042683:Angiopoietin-1 / Q000032:analysis; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use; D044466:Asian People / Q000235:genetics*; D005260:Female; D005753:Gastric Mucosa / Q000378:metabolism / Q000473:pathology; D005838:Genotype; D016481:Helicobacter Infections / Q000188:drug therapy*; D016480:Helicobacter pylori; D006801:Humans; D016209:Interleukin-8 / Q000032:analysis / Q000235:genetics*; D008297:Male; D020780:Matrix Metalloproteinase 9 / Q000032:analysis; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D054328:Proton Pump Inhibitors / Q000627:therapeutic use; D056910:Republic of Korea; D012189:Retrospective Studies; D013274:Stomach Neoplasms / Q000473:pathology / Q000601:surgery; D013997:Time Factors; D042461:Vascular Endothelial Growth Factor A / Q000032:analysis
chemical_list: D042683:Angiopoietin-1; D000900:Anti-Bacterial Agents; D000894:Anti-Inflammatory Agents, Non-Steroidal; D016209:Interleukin-8; D054328:Proton Pump Inhibitors; D042461:Vascular Endothelial Growth Factor A; D020780:Matrix Metalloproteinase 9
keywords: Helicobacter pylori; Interleukin-8; Polymorphism