title: Frailty and mortality, disability and mobility loss in a Spanish cohort of older adults: the FRADEA study.
abstract: BACKGROUND
  Original Fried's frailty criteria have not demonstrated their prognostic validity of mortality, disability and mobility loss in European cohorts.
  
  
  OBJECTIVE
  To analyze whether frailty implies increased risk of death, incident disability in basic (BADL) or instrumental (IADL) activities of daily living, or mobility impairment.
  
  
  METHODS
  Concurrent cohort study.
  
  
  METHODS
  Albacete City, Spain.
  
  
  METHODS
  993 participants over age 70 from the FRADEA Study.
  
  
  METHODS
  Mortality, BADL and mobility using the Barthel Index, and IADL using the Lawton IADL Index, were recorded. BADL disability was defined as loss of the ability to perform bathing, grooming, dressing, toilet use, or feeding, while deterioration of mobility was defined as loss of ability to perform transfers, walk, or use stairs, and IADL disability as losing any of the activities included in the Lawton Index. The risk of presenting adverse events was determined by Cox and Kaplan-Meier proportional hazard analysis and logistic regression adjusted for age, sex, function, and comorbidity.
  
  
  RESULTS
  Mean follow-up was 534 days (SD 153), during which 105 participants (10.6%) died. Mean time to death was 363 days (SD 218), while 192 (25.4%) lost at least one BADL, 492 (60%) at least one IADL, and 222 (28.9%) lost mobility. Frail subjects had a greater adjusted risk of death (HR 5.5, CI 95% 1.5-20.2), of losing BADL (HR 2.5, CI 95% 1.3-4.8), of losing mobility (HR 2.7, CI 95% 1.5-5.0), and of losing IADL (HR 1.9, CI 95% 1.1-3.3) than non-frail patients.
  
  
  CONCLUSIONS
  Fried's frailty criteria are associated with death, incident disability, and mobility impairment in a Spanish cohort of older adults.
authors.affiliation: Complejo Hospitalario Universitario de Albacete, Spain. pabizanda@sescam.jccm.es
authors.forename: Pedro
authors.initials: P
authors.lastname: Abizanda
authors.forename: Luis
authors.initials: L
authors.lastname: Romero
authors.forename: Pedro M
authors.initials: PM
authors.lastname: Sánchez-Jurado
authors.forename: Marta
authors.initials: M
authors.lastname: Martínez-Reig
authors.forename: Llanos
authors.initials: L
authors.lastname: Gómez-Arnedo
authors.forename: Sergio A
authors.initials: SA
authors.lastname: Alfonso
mesh_terms: D000203:Activities of Daily Living; D000368:Aged; D000369:Aged, 80 and over; D015331:Cohort Studies; D005260:Female; D016330:Frail Elderly; D006801:Humans; D008297:Male; D051346:Mobility Limitation; D013030:Spain