title: Time-resolved photoluminescence spectroscopy for the detection of cysteine and other thiol containing amino acids in complex strongly autofluorescent media.
abstract: A thiol probe based on an iridium complex with long-lived photoluminescence was synthesized, which can be used for the detection of thiols even in the presence of strong background fluorescence. This system provides an easy and fast methodology for detecting thiol containing amino acids, which has potential applications in clinical diagnostics.
authors.affiliation: Department of Chemistry, MS-60, Rice University, 6100 S. Main Street, Houston, TX 77005, USA.
authors.forename: Kewei
authors.initials: K
authors.lastname: Huang
authors.forename: Ireneusz W
authors.initials: IW
authors.lastname: Bulik
authors.forename: Angel A
authors.initials: AA
authors.lastname: Martí
mesh_terms: D000596:Amino Acids / Q000737:chemistry*; D056831:Coordination Complexes / Q000138:chemical synthesis / Q000737:chemistry*; D003545:Cysteine / Q000032:analysis*; D005470:Fluorometry; D007495:Iridium / Q000737:chemistry*; D049449:Luminescence; D049408:Luminescent Agents / Q000138:chemical synthesis / Q000737:chemistry*; D008958:Models, Molecular; D013438:Sulfhydryl Compounds / Q000032:analysis*
chemical_list: D000596:Amino Acids; D056831:Coordination Complexes; D049408:Luminescent Agents; D013438:Sulfhydryl Compounds; D007495:Iridium; D003545:Cysteine