title: Anxiety and depression affects life and sleep quality in adults with beta-thalassemia.
abstract: OBJECTIVE
  The aim of this study was to investigate the association of anxiety and depression symptoms with health related quality of life (HRQoL) and sleep quality in patients with beta-thalassemia.
  
  
  METHODS
  In a cross-sectional study between 2006 and 2007, 292 thalassemic patients were assessed for symptoms of anxiety and depression (Hospital Anxiety Depression Scale; HADS), HRQoL (Short Form-36, SF-36) and quality of sleep (Pittsburgh Sleep Quality Index; PSQI). Linear regression models were used to determine possible predictive value of high anxiety and depressive symptoms on HRQoL and sleep quality, separately.
  
  
  RESULTS
  Mental and physical quality of life scores were predicted by symptoms of depression and somatic comorbidities. Total sleep quality was predicted by anxiety symptoms and somatic comorbidities.
  
  
  CONCLUSIONS
  Screening for anxiety and depression in patients with thalassemia is essential. Further studies should test if appropriate treatment of these conditions may improve patients HRQoL and sleep quality or not.
authors.affiliation: Blood Transfusion Research Center, Blood Transfusion Research Center, Tehran, Iran.
authors.forename: Bashir
authors.initials: B
authors.lastname: Hajibeigi
authors.forename: Azita
authors.initials: A
authors.lastname: Azarkeyvan
authors.forename: Seyed Moayed
authors.initials: SM
authors.lastname: Alavian
authors.forename: Maryam Moghani
authors.initials: MM
authors.lastname: Lankarani
authors.forename: Shervin
authors.initials: S
authors.lastname: Assari
keywords: Anxiety; Depression; Health related quality of life; Sleep quality; Thalassemia