title: Hypolipidaemic effects and mechanisms of the main component of Opuntia dillenii Haw. polysaccharides in high-fat emulsion-induced hyperlipidaemic rats.
abstract: The antihyperlipidaemic effects of ODP-Ia, one of the main components of Opuntia dillenii Haw. polysaccharides, were studied. Gavage administration of ODP-Ia was observed to significantly decrease serum lipid levels and to increase serum high-density lipoprotein cholesterol level in hyperlipidaemic rats. Similar suppressive patterns were also seen in hepatic total cholesterol and triglyceride levels. Moreover, the ODP-Ia administration significantly increased serum lecithin:cholesterol acyltransferase activity, increased the production of serum NO, inhibited hepatic HMG-CoA reductase activity, augmented serum and hepatic superoxide dismutase activities and decreased the serum and hepatic malondialdehyde contents in hyperlipidaemic rats. In addition, a histopathological examination revealed that ODP-Ia administration significantly suppressed inflammatory cell infiltration and the expression of VCAM-1. Together, these results indicate that ODP-Ia is a potential natural product for the treatment of hyperlipidaemia-related diseases by improving antioxidant levels, modulating the activities of enzymes involved in cholesterol metabolism, promoting the production of NO and suppressing the expression of VCAM-1, thereby suppressing lipid accumulation and inflammatory cell infiltration.
authors.affiliation: College of Life Science and Technology, Zhanjiang Normal University, Zhanjiang, Guangdong 524048, China. zhaolongyan-dra@163.com
authors.forename: Long-Yan
authors.initials: LY
authors.lastname: Zhao
authors.forename: Wei
authors.initials: W
authors.lastname: Huang
authors.forename: Qing-Xia
authors.initials: QX
authors.lastname: Yuan
authors.forename: Jie
authors.initials: J
authors.lastname: Cheng
authors.forename: Zhen-Chi
authors.initials: ZC
authors.lastname: Huang
authors.forename: Le-Jun
authors.initials: LJ
authors.lastname: Ouyang
authors.forename: Fu-Hua
authors.initials: FH
authors.lastname: Zeng
mesh_terms: D000214:Acyl Coenzyme A / Q000235:genetics / Q000378:metabolism; D000818:Animals; D059305:Diet, High-Fat / Q000009:adverse effects; D004655:Emulsions / Q000009:adverse effects; D006801:Humans; D006949:Hyperlipidemias / Q000188:drug therapy* / Q000209:etiology / Q000235:genetics / Q000378:metabolism; D000960:Hypolipidemic Agents / Q000008:administration & dosage*; D008055:Lipids / Q000097:blood; D008099:Liver / Q000201:enzymology; D008297:Male; D029747:Opuntia / Q000737:chemistry*; D010936:Plant Extracts / Q000008:administration & dosage*; D011134:Polysaccharides / Q000008:administration & dosage*; D051381:Rats; D017207:Rats, Sprague-Dawley; D013482:Superoxide Dismutase / Q000235:genetics / Q000378:metabolism; D014280:Triglycerides / Q000378:metabolism
chemical_list: D000214:Acyl Coenzyme A; D004655:Emulsions; D000960:Hypolipidemic Agents; D008055:Lipids; D010936:Plant Extracts; D011134:Polysaccharides; D014280:Triglycerides; C008047:3-hydroxy-3-methylglutaryl-coenzyme A; D013482:Superoxide Dismutase