title: Clinicopathological evaluation of 164 dental follicles and dentigerous cysts with emphasis on the presence of odontogenic epithelium in the connective  tissue. The hypothesis of "focal ameloblastoma".
abstract: OBJECTIVE
  Some ameloblastomas presumably originate from odontogenic epithelium within the connective tissue of dental follicles and dentigerous cysts. Therefore, it would seem reasonable to discuss as whether odontogenic epithelium proliferations, frankly displaying ameloblastomatous features ("focal ameloblastoma"), should be considered as an "early" ameloblastoma.
  
  
  METHODS
  Histopathological reports from 164 dental follicles and dentigerous cysts from the Department of Oral and Maxillofacial Surgery/Oral Pathology of the VU Free University medical center in Amsterdam, The Netherlands, were reviewed. Histopathological slides from 39 cases reporting the presence of odontogenic epithelium within the connective tissue were re-evaluated in order to assess the possible presence of focal ameloblastomas.
  
  
  RESULTS
  Focal ameloblastomas were detected in one dental follicle and in two dentigerous cysts. During a follow-up period of 6, 8 and 22 years, respectively, no clinical signs of (recurrent) ameloblastoma have occurred in these patients.
  
  
  CONCLUSIONS
  Focal ameloblastoma possibly represents the early stage of ameloblastoma development.
authors.affiliation: Unit of Oral Pathology and Laser-assisted Surgery, Department of Otolaryngological/Dental/ Ophthalmological and Cervico-Facial Sciences, University of Parma, Italy.
authors.forename: Marco
authors.initials: M
authors.lastname: Meleti
authors.forename: Isaäc
authors.initials: I
authors.lastname: van der Waal
mesh_terms: D000564:Ameloblastoma / Q000473:pathology*; D003238:Connective Tissue / Q000473:pathology*; D003795:Dental Sac / Q000473:pathology*; D003803:Dentigerous Cyst / Q000473:pathology*; D004848:Epithelium / Q000473:pathology; D005260:Female; D006801:Humans; D008297:Male; D055815:Young Adult