title: An investigation of the spectrum of common and rare inherited coagulation disorders in north-eastern Iran.
abstract: BACKGROUND
  Health care officials and legislators need accurate data on prevalence and numbers of individuals with bleeding disorders in order to plan and allot their budgets; the manufacturers of coagulation factors also need these data to estimate the amount of factors required to prevent scarcity of these products.
  
  
  METHODS
  We surveyed the prevalence of haemophilia A, haemophilia B, von Willebrand's disease and rare bleeding disorders in North-Eastern Iran. The survey was done in the period from September 2009 to March 2011. Information was collected from the medical records in three major hospitals and a haemophilia centre; the patients' updated data were obtained by telephone.
  
  
  RESULTS
  Overall in the current survey 552 patients with inherited coagulation disorders were identified and their medical records obtained. Of these, 429 (77.5%) had common bleeding disorders (haemophilia A, haemophilia B, von Willebrand's disease), 85 (15.6%) had rare bleeding disorders (deficiency of coagulation factors V, VII, X, XIII, I, XI, combined factor V and VIII deficiency) and 38 (6.9%) had platelet disorders.The commonest bleeding disorders were haemophilia A (n=287, 51.9%), haemophilia B (n=92, 16.6%), von Willebrand's disease (n=50, 9%), factor V deficiency (n=21, 3.8%), factor VII deficiency (n=19, 3.4%), factor X deficiency (n=2, 0.36%), combined factor V and VIII deficiency (n=28, 5.8%), factor XIII deficiency (n=11, 1.99%), factor XI deficiency (n=2, 0.4%), afibrinogenaemia (n=2, 0.36%) and platelet disorders (n=38, 6.9%).
  
  
  CONCLUSIONS
  There is notable population of individuals with bleeding disorders in North-Eastern Iran.
authors.affiliation: Allergy Research Centre, Ghaem Hospital, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran. mansouritorghabeh@mums.ac.ir
authors.forename: Hassan
authors.initials: H
authors.lastname: Mansouritorghabeh
authors.forename: Lida
authors.initials: L
authors.lastname: Manavifar
authors.forename: Abdollah
authors.initials: A
authors.lastname: Banihashem
authors.forename: Alireza
authors.initials: A
authors.lastname: Modaresi
authors.forename: Abbas
authors.initials: A
authors.lastname: Shirdel
authors.forename: Masoud
authors.initials: M
authors.lastname: Shahroudian
authors.forename: Ghazaleh
authors.initials: G
authors.lastname: Shoja-E-Razavi
authors.forename: Hamid
authors.initials: H
authors.lastname: Pousti
authors.forename: Habibollah
authors.initials: H
authors.lastname: Esmaily
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D025861:Blood Coagulation Disorders, Inherited / Q000453:epidemiology*; D001779:Blood Coagulation Factors; D001791:Blood Platelet Disorders / Q000453:epidemiology; D002648:Child; D002675:Child, Preschool; D003625:Data Collection; D005260:Female; D006467:Hemophilia A / Q000453:epidemiology; D002836:Hemophilia B / Q000453:epidemiology; D006474:Hemorrhagic Disorders / Q000453:epidemiology*; D006801:Humans; D007223:Infant; D007492:Iran / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D055815:Young Adult; D014842:von Willebrand Diseases / Q000453:epidemiology
chemical_list: D001779:Blood Coagulation Factors