title: High throughput paper spray mass spectrometry analysis.
abstract: BACKGROUND
  Fast analysis of chemicals in samples of complex mixtures is important for many analytical applications including therapeutic drug monitoring and food safety screening.
  
  
  METHODS
  Based on the paper spray technology developed recently, a high throughput device was developed in this work and used for evaluation of the fast quantitative analysis using paper spray mass spectrometry.
  
  
  RESULTS
  The performance of the method was characterized with bovine blood samples spiked with sunitinib and nicotine. At optimized condition, relatively fast analysis speed of 7s/sample was achieved with relatively good LOQs (1 ng/ml) and quantitation.
  
  
  CONCLUSIONS
  In an application of the method for food screening, LODs better than 1 ng/g were achieved for clenbuterol in beef.
authors.affiliation: Weldon School of Biomedical Engineering, Purdue University, West Lafayette, IN 47907, USA.
authors.forename: Luhou
authors.initials: L
authors.lastname: Shen
authors.forename: Johnny
authors.initials: J
authors.lastname: Zhang
authors.forename: Qian
authors.initials: Q
authors.lastname: Yang
authors.forename: Nicholas E
authors.initials: NE
authors.lastname: Manicke
authors.forename: Zheng
authors.initials: Z
authors.lastname: Ouyang
mesh_terms: D000818:Animals; D002417:Cattle; D002623:Chemistry Techniques, Analytical / Q000379:methods*; D007211:Indoles / Q000097:blood; D013058:Mass Spectrometry / Q000295:instrumentation*; D009538:Nicotine / Q000097:blood; D010209:Paper; D011758:Pyrroles / Q000097:blood; D000077210:Sunitinib; D013997:Time Factors
chemical_list: D007211:Indoles; D011758:Pyrroles; D009538:Nicotine; D000077210:Sunitinib