title: T-cell prolymphocytic leukemia: a report of two cases with review of literature.
abstract: T-cell Prolymphocytic Leukemia (T-PLL) is a mature post-thymic T-cell malignancy with aggressive clinical course. The principal disease characteristics are organomegaly, skin lesions and raised lymphocyte counts. We report two cases of T-PLL. T-PLL is a rare T-cell malignancy with characteristic clinical and laboratory features and a poor prognosis. It needs to be differentiated from B-Cell prolymphocytic leukemia (B-PLL) and other mature T-cell lymphoproliferative disorders with predominant leukemic pattern. Differentiation can be made by a comprehensive approach taking into account the clinical features, the cell morphology and the immunophenotype of leukemic cells.
authors.affiliation: Department of Hematology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Raebarelli Road, Lucknow, Uttar Pradesh, 226 014 India.
authors.forename: Shano
authors.initials: S
authors.lastname: Naseem
authors.forename: Ritu
authors.initials: R
authors.lastname: Gupta
authors.forename: Rajesh
authors.initials: R
authors.lastname: Kashyap
authors.forename: Soniya
authors.initials: S
authors.lastname: Nityanand
keywords: Immunophenotyping; Prolymphocyte; T-PLL