title: The time course changes of choroidal neovascularization in angioid streaks.
abstract: OBJECTIVE
  To assess the clinical course of choroidal neovascularization (CNV) in patients with angioid streaks using optical coherence tomography and fluorescein angiography/indocyanine green angiography.
  
  
  METHODS
  We examined a consecutive series of 88 eyes of 44 patients with angioid streaks using color fundus photography, optical coherence tomography, and fluorescein angiography/indocyanine green angiography.
  
  
  RESULTS
  At the initial visit, 33 eyes exhibited no CNV, 2 exhibited polypoidal choroidal vasculopathy, 8 exhibited Type 1 CNV, 32 exhibited active Type 2 CNV, and 13 exhibited a fibrotic scar. In addition to the 2 eyes that exhibited macular polypoidal choroidal vasculopathy at the initial visit, 3 exhibited peripapillary polypoidal lesions, and 2 exhibited polypoidal lesions at the edge of the preexisting Type 2 CNV/fibrosis. During the follow-up, Type 2 CNV developed in 4 eyes on the basis of Type 1 CNV. Visual acuity was worse in eyes with Type 2 CNV and fibrosis than in those with Type 1 CNV, while polypoidal choroidal vasculopathy did not affect the visual acuity.
  
  
  CONCLUSIONS
  Eyes with angioid streaks can develop any form of CNV including polypoidal choroidal vasculopathy. Considering the worse visual acuity in eyes with Type 2 CNV and fibrosis, patients should be carefully observed so as to treat them promptly when Type 2 CNV occurred beneath the fovea.
authors.affiliation: Department of Ophthalmology and Visual Sciences, Kyoto University Graduate School of Medicine, Kyoto, Japan.
authors.forename: Satoko
authors.initials: S
authors.lastname: Nakagawa
authors.forename: Kenji
authors.initials: K
authors.lastname: Yamashiro
authors.forename: Akitaka
authors.initials: A
authors.lastname: Tsujikawa
authors.forename: Atsushi
authors.initials: A
authors.lastname: Otani
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Tamura
authors.forename: Sotaro
authors.initials: S
authors.lastname: Ooto
authors.forename: Nagahisa
authors.initials: N
authors.lastname: Yoshimura
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D020533:Angiogenesis Inhibitors / Q000627:therapeutic use; D000793:Angioid Streaks / Q000150:complications* / Q000175:diagnosis / Q000628:therapy; D020256:Choroidal Neovascularization / Q000175:diagnosis / Q000209:etiology* / Q000628:therapy; D004396:Coloring Agents; D005260:Female; D005451:Fluorescein Angiography; D006801:Humans; D007208:Indocyanine Green; D008297:Male; D008875:Middle Aged; D010778:Photochemotherapy; D013997:Time Factors; D041623:Tomography, Optical Coherence; D014792:Visual Acuity; D055815:Young Adult
chemical_list: D020533:Angiogenesis Inhibitors; D004396:Coloring Agents; D007208:Indocyanine Green