title: Differential temporal evolution patterns in brain temperature in different ischemic tissues in a monkey model of middle cerebral artery occlusion.
abstract: Brain temperature is elevated in acute ischemic stroke, especially in the ischemic penumbra (IP). We attempted to investigate the dynamic evolution of brain temperature in different ischemic regions in a monkey model of middle cerebral artery occlusion. The brain temperature of different ischemic regions was measured with proton magnetic resonance spectroscopy ((1)H MRS), and the evolution processes of brain temperature were compared among different ischemic regions. We found that the normal (baseline) brain temperature of the monkey brain was 37.16 °C. In the artery occlusion stage, the mean brain temperature of ischemic tissue was 1.16 °C higher than the baseline; however, this increase was region dependent, with 1.72 °C in the IP, 1.08 °C in the infarct core, and 0.62 °C in the oligemic region. After recanalization, the brain temperature of the infarct core showed a pattern of an initial decrease accompanied by a subsequent increase. However, the brain temperature of the IP and oligemic region showed a monotonously and slowly decreased pattern. Our study suggests that in vivo measurement of brain temperature could help to identify whether ischemic tissue survives.
authors.affiliation: Department of Radiology, Tianjin Medical University General Hospital, No 154, Anshan Dao Road, Heping District, Tianjin 300052, China.
authors.forename: Zhihua
authors.initials: Z
authors.lastname: Sun
authors.forename: Jing
authors.initials: J
authors.lastname: Zhang
authors.forename: Yingmin
authors.initials: Y
authors.lastname: Chen
authors.forename: Yunting
authors.initials: Y
authors.lastname: Zhang
authors.forename: Xuejun
authors.initials: X
authors.lastname: Zhang
authors.forename: Hong
authors.initials: H
authors.lastname: Guo
authors.forename: Chunshui
authors.initials: C
authors.lastname: Yu
mesh_terms: D000222:Adaptation, Physiological; D000818:Animals; D001831:Body Temperature; D001833:Body Temperature Regulation; D001921:Brain / Q000503:physiopathology*; D002545:Brain Ischemia / Q000209:etiology* / Q000503:physiopathology*; D020244:Infarction, Middle Cerebral Artery / Q000150:complications* / Q000503:physiopathology*; D008252:Macaca fascicularis; D008297:Male