title: Neutralization activity and kinetics of two broad-range human monoclonal IgG1 derived from recombinant Fab fragments and directed against Hepatitis C virus E2 glycoprotein.
abstract: Hepatitis C virus (HCV) is the major cause of chronic liver disease worldwide. There is evidence that neutralizing anti-HCV antibodies may find potential applications in novel prophylactic and therapeutic strategies. This paper describes the very high neutralization activity and unique biological features of two broadly cross-reactive and cross-neutralizing anti-HCV human monoclonal IgG1 derived from human monoclonal recombinant Fab fragments.
authors.affiliation: Laboratory of Microbiology and Virology, Universita Vita-Salute San Raffaele, Milano, Italy. diotti.robertaantonia@hsr.it
authors.forename: Roberta Antonia
authors.initials: RA
authors.lastname: Diotti
authors.forename: Giuseppe Andrea
authors.initials: GA
authors.lastname: Sautto
authors.forename: Laura
authors.initials: L
authors.lastname: Solforosi
authors.forename: Nicasio
authors.initials: N
authors.lastname: Mancini
authors.forename: Massimo
authors.initials: M
authors.lastname: Clementi
authors.forename: Roberto
authors.initials: R
authors.lastname: Burioni
mesh_terms: D000911:Antibodies, Monoclonal / Q000737:chemistry / Q000235:genetics / Q000276:immunology*; D016174:Hepacivirus / Q000737:chemistry / Q000235:genetics / Q000276:immunology*; D006526:Hepatitis C / Q000276:immunology* / Q000821:virology; D018937:Hepatitis C Antibodies / Q000737:chemistry / Q000235:genetics / Q000276:immunology*; D006801:Humans; D007140:Immunoglobulin Fab Fragments / Q000737:chemistry / Q000235:genetics / Q000276:immunology*; D007074:Immunoglobulin G / Q000737:chemistry / Q000235:genetics / Q000276:immunology*; D007700:Kinetics; D009500:Neutralization Tests; D014759:Viral Envelope Proteins / Q000235:genetics / Q000276:immunology*
chemical_list: D000911:Antibodies, Monoclonal; D018937:Hepatitis C Antibodies; D007140:Immunoglobulin Fab Fragments; D007074:Immunoglobulin G; D014759:Viral Envelope Proteins; C091015:glycoprotein E2, Hepatitis C virus