title: Spermatic cord sarcoma: our experience and review of the literature.
abstract: BACKGROUND
  Spermatic cord tumors represent 4% of scrotal tumors. The most common neoplasms are lipomas. Spermatic cord sarcomas (SCS) of the genitourinary tract account for 2% of all urological tumors. Herein we presented our experience in the treatment of these tumors and a review of the literature.
  
  
  METHODS
  A review of the literature was performed using the Medline database with no restriction on language and date of published papers. The literature search used the following terms: epidemiology, surgery, chemotherapy, radiotherapy and spermatic cord sarcomas. Four cases treated from December 2009 to May 2010 are described.
  
  
  RESULTS
  All patients were treated with radical orchiectomy. The final pathological report showed different types of sarcomas. Two of the patients were treated with adjuvant chemotherapy. 12 months after surgery, 2/4 patients were alive without signs of relapse.
  
  
  CONCLUSIONS
  SCS are very rare tumors with a poor prognosis. SCS's prognostic factors have been identified in grading, size, depth of invasion and surgical margin status. Age and performance status of the patient are however very important. Lymphatic and hematogenous dissemination is uncommon. Surgery is the most important treatment both in the first approach and in local relapse. The role of adjuvant chemotherapy and radiation therapy is still debated.
authors.affiliation: Department of Oncological and Surgical Sciences, Urology Clinic, University of Padua, Padua, Italy. andrea.guttilla @ gmail.com
authors.forename: Andrea
authors.initials: A
authors.lastname: Guttilla
authors.forename: Alessandro
authors.initials: A
authors.lastname: Crestani
authors.forename: Fabio
authors.initials: F
authors.lastname: Zattoni
authors.forename: Silvia
authors.initials: S
authors.lastname: Secco
authors.forename: Massimo
authors.initials: M
authors.lastname: Iafrate
authors.forename: Fabio
authors.initials: F
authors.lastname: Vianello
authors.forename: Claudio
authors.initials: C
authors.lastname: Valotto
authors.forename: Tommaso
authors.initials: T
authors.lastname: Prayer-Galetti
authors.forename: Filiberto
authors.initials: F
authors.lastname: Zattoni
mesh_terms: D000293:Adolescent; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000032:analysis; D001706:Biopsy; D017024:Chemotherapy, Adjuvant; D017809:Fatal Outcome; D005834:Genital Neoplasms, Male / Q000737:chemistry / Q000473:pathology / Q000628:therapy*; D006801:Humans; D007150:Immunohistochemistry; D008175:Lung Neoplasms / Q000556:secondary; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local; D009919:Orchiectomy; D018714:Radiotherapy, Adjuvant; D012509:Sarcoma / Q000737:chemistry / Q000556:secondary / Q000628:therapy*; D013085:Spermatic Cord / Q000737:chemistry / Q000473:pathology / Q000601:surgery*; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: D014408:Biomarkers, Tumor