title: [Pharmacological interaction between meropenem and valproic acid: a report of two cases].
abstract: The pharmacological interaction between meropenem and valproic acid is potentially serious, especially in critically ill patients, resulting in low plasmatic levels of the anticonvulsant. However, to our knowledge, this interaction between meropenem and reduced valproic acid plasma levels has not been reported in the pediatric chilean population. We present two clinical cases of chilean children, thus reporting that this interaction is present in our population, with an aim at educating physicians about the possibility of such interaction.
authors.affiliation: Hospital de niños Dr. Exequiel González Cortés, Santiago, Chile.
authors.forename: Claudio
authors.initials: C
authors.lastname: González
authors.forename: Rodolfo
authors.initials: R
authors.lastname: Villena
mesh_terms: D000927:Anticonvulsants / Q000627:therapeutic use*; D002675:Child, Preschool; D004347:Drug Interactions; D004827:Epilepsy / Q000188:drug therapy; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D007223:Infant; D000077731:Meropenem; D012640:Seizures / Q000188:drug therapy*; D013845:Thienamycins / Q000009:adverse effects*; D014635:Valproic Acid / Q000097:blood / Q000627:therapeutic use*; D065093:beta-Lactamase Inhibitors / Q000627:therapeutic use*
chemical_list: D000927:Anticonvulsants; D013845:Thienamycins; D065093:beta-Lactamase Inhibitors; D014635:Valproic Acid; D000077731:Meropenem