title: Hyperthermia: from diagnostic and treatments to new discoveries.
abstract: Hyperthermia is an important approach for the treatment of several diseases. Hyperthermia is also thought to induce hypertrophy of skeletal muscles in vitro and in vivo, and has been used as a therapeutic tool for millennia. In the first part of our work, we revise several relevant patents related to the utilization of hyperthermia for the treatment and diagnostic of human diseases. In the second part, we present exciting new data on the effects of forced and natural overexpression of HSP72, using murine in vitro (muscle cells) and ex vivo (primary skeletal muscles) models. These studies help to demonstrate that hyperthermia effects are orchestrated by tight coupling between gene expression, protein function, and intracellular Ca2+ signaling pathways with a key role for calcium-induced calcium release. We hope that the review of current patents along with previous unknown information on molecular signaling pathways that underlie the hypertrophy response to hyperthermia in skeletal muscles may trigger the curiosity of scientists worldwide to explore new inventions that fully utilize hyperthermia for the treatment of muscle diseases.
authors.affiliation: University of Missouri-Kansas City, Muscle Biology Research Group-MUBIG, School of Nursing, USA.
authors.forename: Sandra
authors.initials: S
authors.lastname: Romero-Suarez
authors.forename: Chenglin
authors.initials: C
authors.lastname: Mo
authors.forename: Chad
authors.initials: C
authors.lastname: Touchberry
authors.forename: Nuria
authors.initials: N
authors.lastname: Lara
authors.forename: Kendra
authors.initials: K
authors.lastname: Baker
authors.forename: Robin
authors.initials: R
authors.lastname: Craig
authors.forename: Leticia
authors.initials: L
authors.lastname: Brotto
authors.forename: Jon
authors.initials: J
authors.lastname: Andresen
authors.forename: Michael
authors.initials: M
authors.lastname: Wacker
authors.forename: Simon
authors.initials: S
authors.lastname: Kaja
authors.forename: Eduardo
authors.initials: E
authors.lastname: Abreu
authors.forename: Wolfgang
authors.initials: W
authors.lastname: Dillmann
authors.forename: Ruben
authors.initials: R
authors.lastname: Mestril
authors.forename: Marco
authors.initials: M
authors.lastname: Brotto
authors.forename: Thomas
authors.initials: T
authors.lastname: Nosek
mesh_terms: D000818:Animals; D002118:Calcium / Q000378:metabolism; D050884:HSP72 Heat-Shock Proteins / Q000378:metabolism; D006360:Heat-Shock Proteins / Q000378:metabolism; D018869:Heat-Shock Response / Q000235:genetics; D006706:Homeostasis; D006801:Humans; D006979:Hyperthermia, Induced / Q000379:methods*; D066298:In Vitro Techniques; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D008822:Mice, Transgenic; D018832:Molecular Chaperones; D032342:Muscle Cells / Q000166:cytology / Q000378:metabolism; D018485:Muscle Fibers, Skeletal / Q000378:metabolism; D009363:Neoplasm Proteins / Q000378:metabolism; D010766:Phosphorylation; D015398:Signal Transduction
chemical_list: D050884:HSP72 Heat-Shock Proteins; D006360:Heat-Shock Proteins; C486113:Hsbp1 protein, mouse; D018832:Molecular Chaperones; D009363:Neoplasm Proteins; D002118:Calcium