title: Genes encoding homologous antigens in taeniid cestode parasites: Implications for development of recombinant vaccines produced in Escherichia coli.
abstract: Recombinant vaccine antigens are being evaluated for their ability to protect livestock animals against cysticercosis and related parasitic infections. Practical use of some of these vaccines is expected to reduce parasite transmission, leading to a reduction in the incidence of neurocysticercosis and hydatid disease in humans. We recently showed that an antigen (TSOL16), expressed in Escherichia coli, confers high levels of protection against Taenia solium cysticercosis in pigs, which provides a strategy for control of T. solium parasite transmission. Here, we discuss the characteristics of this antigen that may affect the utility of TSOL16 and related antigens for development as recombinant vaccines. We also report that genes encoding antigens closely related to TSOL16 from T. solium also occur in other related species of parasites. These highly homologous antigens have the potential to be used as vaccines and may provide protection against related species of Taenia that cause infection in other hosts.
authors.affiliation: University of Melbourne, Faculty of Veterinary Science, Werribee, VIC, Australia. charlesg@unimelb.edu.au
authors.forename: Charles
authors.initials: C
authors.lastname: Gauci
authors.forename: Marshall W
authors.initials: MW
authors.lastname: Lightowlers
mesh_terms: D000818:Animals; D000947:Antigens, Helminth / Q000235:genetics* / Q000378:metabolism; D004926:Escherichia coli / Q000235:genetics* / Q000378:metabolism; D015870:Gene Expression; D006801:Humans; D041201:Taenia solium / Q000235:genetics* / Q000378:metabolism; D013622:Taeniasis / Q000469:parasitology* / Q000517:prevention & control; D014612:Vaccines / Q000235:genetics* / Q000378:metabolism; D014614:Vaccines, Synthetic / Q000235:genetics* / Q000378:metabolism
chemical_list: D000947:Antigens, Helminth; C512850:TSOL16 antigen, Taenia solium; D014612:Vaccines; D014614:Vaccines, Synthetic
keywords: Cysticercosis; Escherichia; Taenia; antigen; expression; gene; parasite; recombinant; vaccine