title: Assessment of the ototoxicity of docusate sodium (colace) in a guinea pig animal model.
abstract: OBJECTIVE
  Docusate sodium (Colace) is an off-label ceruminolytic agent used to soften ear wax and relieve ear canal obstruction. At present, its effect on hearing in the presence of tympanic membrane (TM) perforation is not clear. The present study aimed to assess the safety of ototopic docusate sodium on hearing in the presence of TM perforation.
  
  
  METHODS
  A prospective, randomized, controlled trial in a guinea pig animal model.
  
  
  METHODS
  Ten guinea pigs underwent bilateral myringotomy. In each animal, one ear received docusate sodium, serving as the experimental ear, and the other received normal saline as the control. Auditory brain response (ABR) was performed at baseline and then 1, 7, and 14 days following the application.
  
  
  RESULTS
  At day 14 following application, there was no significant change in ABR thresholds at 8, 12, 16, 20, or 25 kHz.
  
  
  CONCLUSIONS
  In guinea pigs with perforated TMs, docusate sodium does not seem to cause ototoxicity. Future clinical studies are required.
authors.affiliation: McGill Auditory Sciences Laboratory.
authors.forename: Nader
authors.initials: N
authors.lastname: Emami
authors.forename: Barbara
authors.initials: B
authors.lastname: Ng
authors.forename: Michael
authors.initials: M
authors.lastname: Roskies
authors.forename: Lana
authors.initials: L
authors.lastname: Wazqar
authors.forename: Georges
authors.initials: G
authors.lastname: Makhoul
authors.forename: Dan
authors.initials: D
authors.lastname: Citra
authors.forename: Sam J
authors.initials: SJ
authors.lastname: Daniel
mesh_terms: D000818:Animals; D001309:Auditory Threshold / Q000187:drug effects; D004143:Dioctyl Sulfosuccinic Acid / Q000633:toxicity*; D004427:Ear Diseases / Q000139:chemically induced* / Q000175:diagnosis / Q000503:physiopathology; D016057:Evoked Potentials, Auditory, Brain Stem / Q000187:drug effects*; D006168:Guinea Pigs; D006309:Hearing / Q000187:drug effects*; D023421:Models, Animal; D011446:Prospective Studies; D013501:Surface-Active Agents / Q000633:toxicity
chemical_list: D013501:Surface-Active Agents; D004143:Dioctyl Sulfosuccinic Acid