title: Physiologic response to a simplified venovenous perfusion-induced systemic hyperthermia system.
abstract: Our original venovenous perfusion-induced systemic hyperthermia (vv-PISH) system appeared to significantly improve the survival of patients with lung cancer, but was too complex with numerous dialysis problems. We tested a simplified vv-PISH circuit that includes the Avalon Elite (Avalon Laboratories, LLC, Rancho Dominguez, CA) double lumen cannula, a modified heat exchanger, a water heater/cooler, and a centrifugal pump. The purpose of this study was to evaluate this simplified vv-PISH system (without hemodialyzer) and to investigate the physiologic response to whole-body hyperthermia in pigs. We tested our vv-PISH circuit in healthy adult female swine (n = 7, 55-68 kg). The therapeutic core temperature (42°C), calculated as mean of rectal, bladder, and esophageal temperatures, was achieved in six swine. A maximum difference of 0.5°C was observed between the individual temperature sensor readings, indicating homogeneous heat distribution. Heart rate and mean arterial pressure were transiently altered, but were safely managed. A significant elevation in pulmonary artery pressure occurred during the heating phase, resulting in death of one pig. In all other pigs, pulmonary artery pressure returned to physiologic values during the therapeutic phase. Arterial blood electrolytes were maintained without the need of a dialyzer. Major organ function was within normal parameters. The simplified vv-PISH circuit reliably delivered the hyperthermic dose with no need of dialysis.
authors.affiliation: Cardiothoracic Surgery Division, Department of Surgery, University of Kentucky College of Medicine, Lexington, 40536-0298, USA.
authors.forename: Cherry
authors.initials: C
authors.lastname: Ballard-Croft
authors.forename: Dongfang
authors.initials: D
authors.lastname: Wang
authors.forename: Cameron
authors.initials: C
authors.lastname: Jones
authors.forename: L Ryan
authors.initials: LR
authors.lastname: Sumpter
authors.forename: Xiaoqin
authors.initials: X
authors.lastname: Zhou
authors.forename: Joe
authors.initials: J
authors.lastname: Thomas
authors.forename: Stephen
authors.initials: S
authors.lastname: Topaz
authors.forename: Joseph B
authors.initials: JB
authors.lastname: Zwischenberger
mesh_terms: D000818:Animals; D062186:Arterial Pressure; D005260:Female; D006339:Heart Rate; D006976:Hypertension, Pulmonary / Q000209:etiology; D006979:Hyperthermia, Induced; D007668:Kidney / Q000502:physiology; D008099:Liver / Q000502:physiology; D010477:Perfusion; D011651:Pulmonary Artery / Q000502:physiology; D013552:Swine; D014882:Water-Electrolyte Balance