title: siRNA-based therapeutic approaches for rheumatic diseases.
abstract: RNA interference (RNAi) is one of the most exciting and important discoveries of the past few decades. Small interfering RNAs (siRNAs) can silence gene activity and be used to interfere with pathophysiological processes. Substantial research has focused on introducing 'drug-like' properties-stability, selectivity and potency-to RNAi molecules, and clinical trials have been initiated. Despite initial success, the current challenge that remains is to develop optimized vehicles that avoid off-target effects whilst efficiently delivering the therapeutic siRNA to specific cell types. As for many other diseases, siRNA-based therapy is emerging as a promising approach for the treatment of rheumatic disorders. Although the pathogenesis of rheumatic diseases is complex, identification of candidate genes able to influence either inflammation or structural damage has been successful. Here, we will discuss advances in the field and potential applications of siRNA therapeutics in clinical trials for rheumatic conditions.
authors.affiliation: INSERM, U844, University Hospital Montpellier, 80 avenue Augustin Fliche, 34295 Montpellier, France. florence.apparailly@inserm.fr
authors.forename: Florence
authors.initials: F
authors.lastname: Apparailly
authors.forename: Christian
authors.initials: C
authors.lastname: Jorgensen
mesh_terms: D000818:Animals; D001172:Arthritis, Rheumatoid / Q000188:drug therapy* / Q000235:genetics; D004195:Disease Models, Animal; D016503:Drug Delivery Systems; D020868:Gene Silencing; D006801:Humans; D051379:Mice; D010003:Osteoarthritis / Q000188:drug therapy* / Q000235:genetics; D034622:RNA Interference; D034741:RNA, Small Interfering / Q000008:administration & dosage / Q000627:therapeutic use*; D051381:Rats
chemical_list: D034741:RNA, Small Interfering