title: Chrolactomycins from the actinomycete actinospica.
abstract: Examination of the metabolites produced by an Actinospica strain led to the identification of 6-hydroxychrolactomycin (compound 1), which is produced along with minor amounts of chrolactomycin (compound 2). The structure of 1 was established on the basis of extensive spectroscopic analysis, including one- and two-dimensional NMR. Compound 1 showed antimicrobial activity against Gram-positive bacteria, although it was generally less active than 2.
authors.affiliation: NAICONS Scrl , Via Fantoli 16/15, 20138 Milano, Italy.
authors.forename: Marianna
authors.initials: M
authors.lastname: Iorio
authors.forename: Sonia I
authors.initials: SI
authors.lastname: Maffioli
authors.forename: Eleonora
authors.initials: E
authors.lastname: Gaspari
authors.forename: Rossana
authors.initials: R
authors.lastname: Rossi
authors.forename: Pierluigi
authors.initials: P
authors.lastname: Mauri
authors.forename: Margherita
authors.initials: M
authors.lastname: Sosio
authors.forename: Stefano
authors.initials: S
authors.lastname: Donadio
mesh_terms: D000192:Actinomycetales / Q000737:chemistry*; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004224:Diterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D006094:Gram-Positive Bacteria / Q000187:drug effects*; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular
chemical_list: C587748:6-hydroxychrolactomycin; D000900:Anti-Bacterial Agents; D004224:Diterpenes; C511716:chrolactomycin