title: [Gitelman syndrome in pregnancy--a severe hypokalemia with favorable perinatal prognosis].
abstract: Gitelman syndrom is a rare congenital tubulopathy characterized by hypokalemia, hypomagnesemia, metabolic alkalosis and hypocalciuria. We report a case of a 32-year-old patient admitted for asymptomatic hypokalemia and hypomagnesemia in the 30th week of gestation. A diagnosis of Gitelman syndrom was made and intravenous administration of potassium chloride in high doses combined with spironolactone was started. Despite intensive potassium supplementation (8 g/day), the serum potassium levels remained at the lower limit of normality throughout the pregnancy. The patient delivered a healthy female 2670 g/48 cm after labor induction in the 39th week of gestation. A summary of 22 so far published cases of Gitelman syndrome in pregnancy is presented. The analysis of published case studies suggests a need for ion supplementation, reduction of urinary potassium wasting, monitoring of fetal well-being and amniotic fluid levels. Pregnancy has a very favorable perinatal prognosis despite critical serum levels of potassium and magnesium throughout the pregnancy.
authors.affiliation: Gynekologicko-porodnická klinika LF a FN, Plzen, prednosta doc. MUDr. Z. Novotný, CSc. rusavy@fnplzen.cz
authors.forename: Z
authors.initials: Z
authors.lastname: Rušavý
authors.forename: A
authors.initials: A
authors.lastname: Hudec
authors.forename: J
authors.initials: J
authors.lastname: Karbanová
authors.forename: V
authors.initials: V
authors.lastname: Korečko
authors.forename: R
authors.initials: R
authors.lastname: Janů
authors.forename: V
authors.initials: V
authors.lastname: Kališ
mesh_terms: D000328:Adult; D005260:Female; D053579:Gitelman Syndrome / Q000175:diagnosis / Q000628:therapy; D006801:Humans; D007231:Infant, Newborn; D011247:Pregnancy; D011248:Pregnancy Complications / Q000175:diagnosis / Q000628:therapy; D011256:Pregnancy Outcome; D011379:Prognosis