title: [Antifibrillatory activity of dipeptide antagonist of nerve growth factor].
abstract: In experiments on anesthetized rats were assessed antifibrillatoty action of dipeptide GK-1. This compound is the fragment of fourth loop of nerve growth factor (NGF) and manifests antagonistic activity in respect to TrkA receptor, that specified for NGF. It is shown that this compound is able to significantly increase the threshold of electrical fibrillation of the heart and its effectiveness is not inferior to the reference antiarrhythmics I and III class on Vaughan Williams classification. However, unlike the latter, antifibrillatory action of dipeptide GK-1 was delayed and realized within 40-60 minutes after its administration. It is discussed possible mechanisms underlying antifibrillatory action of dipeptide GK-1, that, to some extent, may be associated with its ability to change the reactivity of beta-adrenergic structures of the heart.
authors.forename: S A
authors.initials: SA
authors.lastname: Kryzhanovskiĭ
authors.forename: V N
authors.initials: VN
authors.lastname: Stoliarchuk
authors.forename: M B
authors.initials: MB
authors.lastname: Vititnova
authors.forename: I B
authors.initials: IB
authors.lastname: Tsorin
authors.forename: E S
authors.initials: ES
authors.lastname: Pekel'dina
authors.forename: T A
authors.initials: TA
authors.lastname: Gudasheva
mesh_terms: D000818:Animals; D000889:Anti-Arrhythmia Agents / Q000494:pharmacology*; D001281:Atrial Fibrillation / Q000188:drug therapy / Q000503:physiopathology; D004151:Dipeptides / Q000494:pharmacology*; D006321:Heart / Q000503:physiopathology*; D008297:Male; D020932:Nerve Growth Factor / Q000037:antagonists & inhibitors*; D051381:Rats; D020917:Receptor, trkA / Q000037:antagonists & inhibitors; D013997:Time Factors
chemical_list: D000889:Anti-Arrhythmia Agents; D004151:Dipeptides; D020932:Nerve Growth Factor; D020917:Receptor, trkA