title: Evidence for a beneficial effect of glucose-insulin-potassium in patients with acute coronary syndromes: Did the IMMEDIATE trial solve an unanswered question?
abstract: Evaulation of: Selker HP, Beshansky JR, Sheehan PR et al. Out-of-hospital administration of intravenous glucose-insulin-potassium in patients with suspected acute coronary syndromes: the IMMEDIATE randomized controlled trial. JAMA 9(307), 1925-1933 (2012).   Catecholamine release in conjunction with an acute coronary syndrome induces metabolic changes that impair the situation for the ischemic myocardium. Attempts have been made to improve the prognosis in patients with acute coronary syndrome by means of infusing glucose-insulin-potassium in order to improve glucose metabolism and decrease beta-oxidation of free fatty acids. A trial, IMMEDIATE, tested this concept in a new way by initiating glucose-insulin-potassium during transportation to hospital, is discussed in this article.
authors.affiliation: Department of Medicine Solna, Cardiology Unit, Karolinska Institutet, Solna, Sweden. linda.melbin@karolinska.se
authors.forename: Linda
authors.initials: L
authors.lastname: Mellbin
authors.forename: Lars
authors.initials: L
authors.lastname: Rydén
mesh_terms: D054058:Acute Coronary Syndrome / Q000188:drug therapy*; D002314:Cardioplegic Solutions / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008297:Male; D009203:Myocardial Infarction / Q000517:prevention & control*
chemical_list: D002314:Cardioplegic Solutions