title: Drug trafficking: recent advances in therapeutics and disease.
abstract: Drug transporter proteins are of ever-increasing interest because of their role both in processes regulating pharmacokinetic properties of drugs (absorption, distribution, and elimination) and in the development of cellular drug resistance through decreased uptake or increased efflux of drugs in the target organ or tumor. Further understanding of the role of transporters in drug-drug interactions and identification of these proteins as possible therapeutic targets could contribute to improved treatment of a wide variety of diseases.
authors.forename: J A
authors.initials: JA
authors.lastname: Sprowl
authors.forename: A
authors.initials: A
authors.lastname: Sparreboom
mesh_terms: D001692:Biological Transport; D016503:Drug Delivery Systems; D004347:Drug Interactions; D004351:Drug Resistance; D006801:Humans; D026901:Membrane Transport Proteins / Q000378:metabolism*; D004364:Pharmaceutical Preparations / Q000378:metabolism*; D010599:Pharmacokinetics
chemical_list: D026901:Membrane Transport Proteins; D004364:Pharmaceutical Preparations