title: Post-treatment levels of stem cell factor and hs-CRP in serum and crevicular fluid of chronic periodontitis subjects with type 2 diabetes.
abstract: OBJECTIVE
  The purpose of this study is to evaluate the stem cell factor (SCF) and high sensitive C reactive protein (hs-CRP) concentration in gingival crevicular fluid (GCF) and serum of chronic periodontitis subjects with type 2 diabetes, and to evaluate the effect of nonsurgical periodontal therapy on their GCF and serum concentrations.
  
  
  METHODS
  A total of (age and gender matched) 22 subjects were evaluated. Pre- and post-treatment levels of SCF and hs-CRP in GCF and serum were measured and compared using enzyme linked immunosorbant assay. Clinical parameters including probing depth and clinical attachment level were also measured. Paired t-test was used to compare the before- and after-treatment levels of the two molecules.
  
  
  RESULTS
  A highly significant difference (P < 0.001) was found in the GCF and serum concentrations of SCF and hs-CRP before and after treatment.
  
  
  CONCLUSIONS
  Our observations indicated that short-term nonsurgical therapy resulted in a significant improvement in periodontal indices and in a marked decrease of SCF and hs-CRP serum and GCF levels.
authors.affiliation: Department of Periodontics, Government Dental College and Research Institute, Bangalore, India. periodonticsgdcri@gmail.com
authors.forename: Avani R
authors.initials: AR
authors.lastname: Pradeep
authors.forename: Nitish
authors.initials: N
authors.lastname: Kalra
authors.forename: N
authors.initials: N
authors.lastname: Priyanka
authors.forename: Minal
authors.initials: M
authors.lastname: Kumari
authors.forename: Ella
authors.initials: E
authors.lastname: Khaneja
authors.forename: Savitha B
authors.initials: SB
authors.lastname: Naik
mesh_terms: D000328:Adult; D002097:C-Reactive Protein / Q000032:analysis*; D016022:Case-Control Studies; D055113:Chronic Periodontitis / Q000097:blood / Q000150:complications* / Q000378:metabolism / Q000628:therapy*; D003430:Cross-Sectional Studies; D012534:Dental Scaling; D003924:Diabetes Mellitus, Type 2 / Q000150:complications*; D005260:Female; D005883:Gingival Crevicular Fluid / Q000737:chemistry*; D006801:Humans; D018836:Inflammation Mediators / Q000097:blood / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D019089:Stem Cell Factor / Q000032:analysis* / Q000097:blood
chemical_list: D018836:Inflammation Mediators; D019089:Stem Cell Factor; D002097:C-Reactive Protein