title: Bone marrow microenvironment in multiple myeloma progression.
abstract: Substantial advances have been made in understanding the biology of multiple myeloma (MM) through the study of the bone marrow (BM) microenvironment. Indeed, the BM niche appears to play an important role in differentiation, migration, proliferation, survival, and drug resistance of the malignant plasma cells. The BM niche is composed of a cellular compartment (stromal cells, osteoblasts, osteoclasts, endothelial cells, and immune cells) and a noncellular compartment including the extracellular matrix (ECM) and the liquid milieu (cytokines, growth factors, and chemokines). In this paper we discuss how the interaction between the malignant plasma cell and the BM microenvironment allowed myeloma progression through cell homing and the new concept of premetastatic niche.
authors.affiliation: Dana-Farber Cancer Institute, Department of Medical Oncology, Harvard Medical School, 450 Brookline Avnue, HIM 246, Boston, MA 02215, USA.
authors.forename: S
authors.initials: S
authors.lastname: Manier
authors.forename: A
authors.initials: A
authors.lastname: Sacco
authors.forename: X
authors.initials: X
authors.lastname: Leleu
authors.forename: I M
authors.initials: IM
authors.lastname: Ghobrial
authors.forename: A M
authors.initials: AM
authors.lastname: Roccaro
mesh_terms: D000818:Animals; D001853:Bone Marrow / Q000276:immunology*; D016207:Cytokines / Q000276:immunology*; D006801:Humans; D018448:Models, Immunological; D009101:Multiple Myeloma / Q000276:immunology*
chemical_list: D016207:Cytokines