title: The long and short of it: the role of telomeres in fetal origins of adult disease.
abstract: Placental insufficiency, maternal malnutrition, and other causes of intrauterine growth restriction (IUGR) can significantly affect short-term growth and long-term health. Following IUGR, there is an increased risk for cardiovascular disease and Type 2 Diabetes. The etiology of these diseases is beginning to be elucidated, and premature aging or cellular senescence through increased oxidative stress and DNA damage to telomeric ends may be initiators of these disease processes. This paper will explore the areas where telomere and telomerase biology can have significant effects on various tissues in the body in IUGR outcomes.
authors.affiliation: Department of Physiology and Pharmacology, University of Western Ontario, Ontario, London, ON, Canada N6A 5C1.
authors.forename: Stephanie E
authors.initials: SE
authors.lastname: Hallows
authors.forename: Timothy R H
authors.initials: TR
authors.lastname: Regnault
authors.forename: Dean H
authors.initials: DH
authors.lastname: Betts
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000378:metabolism; D002318:Cardiovascular Diseases / Q000209:etiology* / Q000235:genetics; D003924:Diabetes Mellitus, Type 2 / Q000209:etiology* / Q000235:genetics; D005260:Female; D005317:Fetal Growth Retardation / Q000201:enzymology / Q000209:etiology / Q000235:genetics / Q000503:physiopathology*; D006801:Humans; D008297:Male; D010063:Ovum / Q000502:physiology; D010920:Placenta / Q000201:enzymology / Q000503:physiopathology; D010927:Placental Insufficiency / Q000201:enzymology / Q000235:genetics / Q000503:physiopathology*; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects / Q000209:etiology* / Q000235:genetics; D013094:Spermatozoa / Q000502:physiology; D019098:Telomerase / Q000378:metabolism; D016615:Telomere / Q000502:physiology*; D059506:Telomere Shortening / Q000502:physiology
chemical_list: D015415:Biomarkers; D019098:Telomerase