title: Inhibitory potential of a novel imidazole derivative as evaluated by time-kill and dehydrogenase activity.
abstract: Antibacterial activity of 1,1'-methandiylbis(2-methyl-1H-imidazole) (AIM) has been estimated both qualitatively and quantitatively against reference and clinical strains of Gram-positive and Gram-negative bacteria. MICs showed little variability among strains tested, ranging from 360 to 450 μg/ml and indicating rather a moderate antibacterial activity. Inhibition of dehydrogenase activity was significant in Escherichia coli ATCC 25922 and followed closely time-kill dynamics. Although moderate, AIM proved also to be useful on the ability to successfully inhibit the growth of antibiotic resistant clinical strains.
authors.affiliation: Department of Biology-Ecology, Faculty of Natural Sciences and Agricultural Sciences, Ovidius University of Constanta, 1, University Street, 900470, Constanta, Romania. microbiologie_universitate_f_a@yahoo.com
authors.forename: Florin
authors.initials: F
authors.lastname: Aonofriesei
authors.forename: Simona
authors.initials: S
authors.lastname: Lupsor
mesh_terms: D000890:Anti-Infective Agents / Q000737:chemistry / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects* / Q000201:enzymology*; D007093:Imidazoles / Q000737:chemistry / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests / Q000379:methods; D050296:Microbial Viability / Q000187:drug effects*; D010088:Oxidoreductases / Q000032:analysis*; D013997:Time Factors
chemical_list: D000890:Anti-Infective Agents; D007093:Imidazoles; C029899:imidazole; D010088:Oxidoreductases