title: Effect of fangchinoline on root resorption during rat orthodontic tooth movement.
abstract: OBJECTIVE
  To evaluate the short-term effect of fangchinoline, an antiinflammatory drug widely used in Asia, on root resorption that is associated with orthodontic tooth movement.
  
  
  METHODS
  Twenty-four Wistar rats were randomly divided into 6 groups. Mesial forces of 0, 50, or 100 g were applied to the maxillary first molar of the rats in each group for 14 days by activating nickel-titanium closed-coil springs. One-half of the rats receiving each of these treatments also received injections of 200 µL fangchinoline every 2 days. Finally, movement of the maxillary first molars was measured using digitized radiographs. The molars were extracted and the surfaces of the root resorption craters were recorded using a scanning electron microscope. The distance the molars moved and resorptionarea ratio was measured, and results were analyzed using 2-way ANOVA tests.
  
  
  RESULTS
  There were no statistical differences in the distances the first molars moved under 50 or 100 g force, regardless of treatment with fangchinoline. However, the resorption area ratios were significantly smaller in those rats that were treated with both tension and fangchinoline than in those rats treated by tension alone.
  
  
  CONCLUSIONS
  Fangchinoline reduced the resorption area ratio in rats and is therefore an important means of alleviating root resorption.
authors.affiliation: Department of Orthodontics, School of Stomatology, Jilin University, Changchun, China.
authors.forename: Xingfu
authors.initials: X
authors.lastname: Bao
authors.forename: Min
authors.initials: M
authors.lastname: Hu
authors.forename: Yi
authors.initials: Y
authors.lastname: Zhang
authors.forename: Ferdinand
authors.initials: F
authors.lastname: Machibya
authors.forename: Ying
authors.initials: Y
authors.lastname: Zhang
authors.forename: Huan
authors.initials: H
authors.lastname: Jiang
authors.forename: Dongsheng
authors.initials: D
authors.lastname: Yu
keywords: Root resorption; SEM; Tooth movement