title: [Effects of dehydroepiandrosteron sulfat on induced apoptosis of lymphocytes in healthy persons].
abstract: Effects of dehydroepiandrosteron sulfate on oxidative stress- and ethanol-induced morphological changes and level of apoptotic enzymes (Bcl-2 and caspase-3) of lymphocytes in healthy persons have been studied. This study showed that hydroperoxide induces apoptotic changes in lymphocytes. Ethanol did not change the basal concentration of apoptotic enzyme. Dehydroepiandrosteron sulfate prevented the augmentation of apoptosis in hydroperoxide-treated lymphocytes.
authors.forename: E V
authors.initials: EV
authors.lastname: Zhernova
authors.forename: S A
authors.initials: SA
authors.lastname: Ivanova
mesh_terms: D000328:Adult; D017209:Apoptosis / Q000187:drug effects*; D053148:Caspase 3 / Q000378:metabolism; D019314:Dehydroepiandrosterone Sulfate / Q000494:pharmacology*; D000431:Ethanol / Q000494:pharmacology; D005260:Female; D006801:Humans; D008214:Lymphocytes / Q000166:cytology / Q000378:metabolism*; D008297:Male; D018384:Oxidative Stress / Q000187:drug effects*; D019253:Proto-Oncogene Proteins c-bcl-2 / Q000378:metabolism; D012997:Solvents / Q000494:pharmacology
chemical_list: D019253:Proto-Oncogene Proteins c-bcl-2; D012997:Solvents; D000431:Ethanol; D019314:Dehydroepiandrosterone Sulfate; C505407:CASP3 protein, human; D053148:Caspase 3