title: Studying dissolution with a model integrating solid-liquid interface kinetics and diffusion kinetics.
abstract: A dissolution model that integrates the solid-liquid interface kinetics and the mass transport kinetics is introduced. Such a model reduces to the Noyes-Whitney equation under special conditions, but offers expanded range of applicability and flexibility fitting dissolution profiles when interfacial kinetics and interfacial concentration deviate from the assumptions implied in the Noyes-Whitney equation. General solutions to the integrated dissolution model derived for noninteractive solutes as well as for solutes participating in ionization equilibrium are discussed. Parameters defining the integrated dissolution model are explained conceptually along with practical ways for their determinations. Conditions under which the model exhibits supersaturation features are elaborated. Simulated dissolution profiles using the integrated dissolution model for published experimental data exhibiting supersaturation features are illustrated.
authors.affiliation: Small Molecule Pharmaceutical Sciences, Genentech, Inc., a member of the Roche Group, South San Francisco, California, USA. jeff.yanggao@gmail.com
authors.forename: Jeff Y
authors.initials: JY
authors.lastname: Gao
mesh_terms: D004058:Diffusion; D007700:Kinetics; D008956:Models, Chemical; D012995:Solubility; D012996:Solutions / Q000493:pharmacokinetics*
chemical_list: D012996:Solutions