title: A missing link in genotype-directed cancer therapy.
abstract: Genotype-directed therapy holds great promise for the treatment of cancer, but crosstalk between signaling pathways often confounds simple genotype-drug response relationships. To deliver on the promise of precision medicine, a coordinated effort is needed to make a comprehensive inventory of the many signaling feedback circuits that exist in cancer cells.
authors.affiliation: Division of Molecular Carcinogenesis, Center for Biomedical Genetics and Cancer Genomics Center, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands. r.bernards@nki.nl
authors.forename: René
authors.initials: R
authors.lastname: Bernards
mesh_terms: D000970:Antineoplastic Agents / Q000378:metabolism / Q000627:therapeutic use*; D004347:Drug Interactions; D025461:Feedback, Physiological; D005838:Genotype; D006801:Humans; D009369:Neoplasms / Q000145:classification / Q000188:drug therapy* / Q000235:genetics*; D057285:Precision Medicine; D015398:Signal Transduction
chemical_list: D000970:Antineoplastic Agents