title: Four new sesquiterpenoids from Ligularia cymbulifera.
abstract: Four new highly oxygenated bisabolane sesquiterpenoids were obtained from the EtOH extract from Ligularia cymbulifera, and their structures were elucidated by interpretation of spectroscopic data. Their relative configurations were clarified by a detailed analysis of ¹H NMR coupling constants, nuclear overhauser effect (NOE) experiments and two-dimensional NMR spectra. These four new compounds were assayed for their antimicrobial activities against four Gram-positive and Gram-negative bacteria, as well as against one human pathogenic fungus.
authors.affiliation: School of Biotechnology and Chemical Engineering, Ningbo Institute of Technology, Zhejiang University, Ningbo 315100, China.
authors.forename: Yu-Xue
authors.initials: YX
authors.lastname: Wu
authors.forename: Yan-Jun
authors.initials: YJ
authors.lastname: Chen
authors.forename: Chun-Mei
authors.initials: CM
authors.lastname: Liu
authors.forename: Kun
authors.initials: K
authors.lastname: Gao
mesh_terms: D019659:Asteraceae / Q000737:chemistry*; D002176:Candida albicans / Q000187:drug effects; D016972:Enterobacter cloacae / Q000187:drug effects; D004926:Escherichia coli / Q000187:drug effects; D006801:Humans; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D011550:Pseudomonas aeruginosa / Q000187:drug effects; D012717:Sesquiterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D013211:Staphylococcus aureus / Q000187:drug effects
chemical_list: D012717:Sesquiterpenes