title: Hedgehog pathway inhibitors - current status and future prospects.
abstract: The Hedgehog (Hh) proteins comprise a group of secreted proteins that regulate cell growth, differentiation and survival. Inappropriate activation of the Hh signaling pathway has been implicated in the development of a variety of cancers. Hedgehog pathway inhibitors are a relatively new class of therapeutic agents that act by targeting the proteins involved in the regulation of Hh pathway (PTCH, SMO and Gli). Together, they serve as exciting new prospects, with a bright future, both alone or as an adjuvant to the more traditional anti-cancer drugs.
authors.affiliation: Dow Medical College, Dow University of Health Sciences, Baba-e-Urdu Road, Karachi 74200, Pakistan. asfandyarsheikh@gmail.com.
authors.forename: Asfandyar
authors.initials: A
authors.lastname: Sheikh
authors.forename: Arsalan Ahmad
authors.initials: AA
authors.lastname: Alvi
authors.forename: Hafiz Muhammad
authors.initials: HM
authors.lastname: Aslam
authors.forename: Abdul
authors.initials: A
authors.lastname: Haseeb