title: [Tobacco smoking and latent tuberculous infection].
abstract: Tobacco smoking has a significant impact on the risk of tuberculosis and the mortality of the disease. There is a strong dose-response relationship both in terms of quantity and duration of smoking. Latent tuberculous infection and tuberculosis disease are different stages of the same infectious process but the relation between smoking and the risk of being infected with Mycobacterium tuberculosis is less well understood. The aim of this review is to describe the relationship between tobacco consumption and tuberculous infection and the mechanism by which smoking increases the risk. It outlines the public health consequences of the increased risk of latent tuberculous infection due to active and passive smoking. This justifies promotion of smoking cessation as a way of limiting the epidemic of tuberculosis in developing countries.
authors.affiliation: Unité de tabacologie, service de pneumologie, centre de lutte antituberculeuse (CLAT 86), CHU la Milétrie, pavillon René-Beauchant, 2, rue Milétrie, BP 577, 86021 Poitiers cedex, France. m.underner@chu-poitiers.fr
authors.forename: M
authors.initials: M
authors.lastname: Underner
authors.forename: J
authors.initials: J
authors.lastname: Perriot
authors.forename: V
authors.initials: V
authors.lastname: Trosini-Desert
authors.forename: G
authors.initials: G
authors.lastname: Ouedreaogo
authors.forename: G
authors.initials: G
authors.lastname: Peiffer
authors.forename: J-C
authors.initials: JC
authors.lastname: Meurice
authors.forename: B
authors.initials: B
authors.lastname: Dautzenberg
mesh_terms: D003906:Developing Countries / Q000706:statistics & numerical data; D014943:Global Health; D006801:Humans; D055985:Latent Tuberculosis / Q000453:epidemiology* / Q000503:physiopathology* / Q000517:prevention & control; D009169:Mycobacterium tuberculosis; D012307:Risk Factors; D012907:Smoking / Q000009:adverse effects* / Q000453:epidemiology* / Q000503:physiopathology; D016540:Smoking Cessation; D014397:Tuberculosis, Pulmonary / Q000453:epidemiology / Q000503:physiopathology