title: Plasma MDA and antioxidant vitamins in diabetic retinopathy.
abstract: Hyperglycemia and dyslipidemia in diabetes mellitus induce increased lipid peroxidation and peroxyl radical formation, an important mechanism in genesis of microangiopathy. We took up a study on oxidative stress, measured by plasma MDA and antioxidant vitamin status in type - 2 DM patients with and without retinopathy and compared them with a control non-diabetic group. Lipid peroxidation marker MDA was significantly elevated (p < 0.001) in both the diabetic groups whereas, serum vitamin E and vitamin C registered a significant fall (p<0.001) as compared to controls. Our correlation study revealed a significant positive association between plasma MDA with both fasting and 2hr post prandial plasma glucose (r=0.81, p < 0.001, r=0.92, p <0.001) suggesting the role of hyperglycemia in free radical production. Plasma MDA also depicted significant positive relation (p< 0.001) with all lipid parameters except serum HDLc pointing the role of dyslipidemia towards lipid peroxidation. Plasma MDA level was also found to be negatively correlated with both the vitamins (p<0.001, p<0.001) in the study group explaining their protective consumption in the oxidative process prevailing in diabetic retinopathy.
authors.affiliation: Department of Biochemistry, SCB Medical College, Cuttack, 753007 Orissa India.
authors.forename: S
authors.initials: S
authors.lastname: Kumari
authors.forename: S
authors.initials: S
authors.lastname: Panda
authors.forename: M
authors.initials: M
authors.lastname: Mangaraj
authors.forename: M K
authors.initials: MK
authors.lastname: Mandal
authors.forename: P C
authors.initials: PC
authors.lastname: Mahapatra
keywords: Microangiopathy; Oxidative stress; Peroxy radical