title: Highly enantioselective organocatalytic Strecker reaction of cyclic N-acyl trifluoromethylketimines: synthesis of anti-HIV drug DPC 083.
abstract: A highly efficient, organocatalytic, enantioselective Strecker reaction of cyclic N-acyl ketimines was developed for the preparation of enantioenriched cyclic α-amino nitriles with a quaternary carbon stereocentre and anti-HIV drug DPC 083.
authors.affiliation: Department of Chemistry, Tianjin University, Tianjin 300072, China.
authors.forename: Fa-Guang
authors.initials: FG
authors.lastname: Zhang
authors.forename: Xiao-Yan
authors.initials: XY
authors.lastname: Zhu
authors.forename: Shen
authors.initials: S
authors.lastname: Li
authors.forename: Jing
authors.initials: J
authors.lastname: Nie
authors.forename: Jun-An
authors.initials: JA
authors.lastname: Ma
mesh_terms: D019380:Anti-HIV Agents / Q000138:chemical synthesis* / Q000737:chemistry; D002384:Catalysis; D060326:Chemistry Techniques, Synthetic; D007097:Imines / Q000737:chemistry*; D009570:Nitriles / Q000737:chemistry*; D011799:Quinazolines / Q000138:chemical synthesis* / Q000737:chemistry; D013237:Stereoisomerism; D013379:Substrate Specificity; D013890:Thiourea / Q000737:chemistry
chemical_list: D019380:Anti-HIV Agents; C430648:DPC 083; D007097:Imines; D009570:Nitriles; D011799:Quinazolines; C542835:ketimine; D013890:Thiourea