title: Role of tumor necrosis factor-like weak inducer of apoptosis (TWEAK)/fibroblast growth factor-inducible 14 (Fn14) axis in rheumatic diseases.
abstract: Tumor necrosis factor (TNF)-like weak inducer of apoptosis (TWEAK) is a member of the TNF superfamily of structurally related cytokines and is known to induce proliferation, migration, differentiation, apoptotic cell death, inflammation, and angiogenesis. These physiological processes are induced by the binding of TWEAK to fibroblast growth factor-inducible 14 (Fn14), a highly inducible cell-surface receptor that is linked to several intracellular signaling pathways, including the nuclear factor-κB (NF-κB) pathway. This review discusses the role of the TWEAK-Fn14 axis in several rheumatic diseases and the potential therapeutic benefits of modulation of the TWEAK-Fn14 pathway.
authors.affiliation: Department of Rheumatology, First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang 150001, China.
authors.forename: Li-Xiu
authors.initials: LX
authors.lastname: Zhu
authors.forename: Hai-Hong
authors.initials: HH
authors.lastname: Zhang
authors.forename: Yi-Fang
authors.initials: YF
authors.lastname: Mei
authors.forename: Yan-Ping
authors.initials: YP
authors.lastname: Zhao
authors.forename: Zhi-Yi
authors.initials: ZY
authors.lastname: Zhang
mesh_terms: D001172:Arthritis, Rheumatoid / Q000209:etiology; D000074049:Cytokine TWEAK; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000209:etiology; D018124:Receptors, Tumor Necrosis Factor / Q000502:physiology*; D012216:Rheumatic Diseases / Q000209:etiology*; D012595:Scleroderma, Systemic / Q000209:etiology; D000074050:TWEAK Receptor; D048069:Tumor Necrosis Factors / Q000502:physiology*
chemical_list: D000074049:Cytokine TWEAK; D018124:Receptors, Tumor Necrosis Factor; C000613297:TNFRSF12A protein, human; C109743:TNFSF12 protein, human; D000074050:TWEAK Receptor; D048069:Tumor Necrosis Factors