title: Helicobacter pylori infection and gastric carcinogenesis in rodent models.
abstract: Helicobacter pylori infection is an important factor for gastric carcinogenesis in human. In carcinogen-treated Mongolian gerbils, H. pylori infection enhances stomach carcinogenesis, while infection alone induced severe hyperplasia called heterotopic proliferative glands. A high-salt diet or early acquisition of the bacteria exacerbates inflammation and carcinogenesis. Oxygen radical scavengers or anti-inflammatory chemicals as well as eradication of H. pylori are effective to prevent carcinogenesis. H. pylori-associated inflammation induces intestinal metaplasia and intestinalization of stomach cancers independently. It is necessary to control cancer development not only in H. pylori-positive cases but also in H. pylori-negative metaplastic gastritis.
authors.affiliation: Department of Diagnostic Pathology, Fujita Health University School of Medicine, 1-98 Dengakugakubo, Kutsukake-cho, Toyoake, Aichi 470-1192, Japan. ttsukamt@fujita-hu.ac.jp
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Tsukamoto
authors.forename: Takeshi
authors.initials: T
authors.lastname: Toyoda
authors.forename: Tsutomu
authors.initials: T
authors.lastname: Mizoshita
authors.forename: Masae
authors.initials: M
authors.lastname: Tatematsu
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use*; D016166:Free Radical Scavengers / Q000627:therapeutic use*; D005849:Gerbillinae; D016481:Helicobacter Infections / Q000150:complications / Q000188:drug therapy* / Q000276:immunology / Q000473:pathology; D016480:Helicobacter pylori / Q000276:immunology*; D006801:Humans; D008679:Metaplasia / Q000209:etiology / Q000276:immunology / Q000382:microbiology / Q000473:pathology / Q000517:prevention & control; D051379:Mice; D009374:Neoplasms, Experimental / Q000276:immunology / Q000382:microbiology / Q000473:pathology / Q000517:prevention & control; D051381:Rats; D013274:Stomach Neoplasms / Q000209:etiology / Q000276:immunology / Q000382:microbiology / Q000473:pathology / Q000517:prevention & control
chemical_list: D000893:Anti-Inflammatory Agents; D016166:Free Radical Scavengers