title: [The role of prenatal hyperandrogenism on lipid metabolism during adult life in a rat model].
abstract: Polycystic ovary syndrome (PCOS) is one of the commonest endocrine diseases that affect women in their reproductive ages; however, the etiology of the syndrome remains unknown. A hypothesis proposes that during gestation increased exposure of androgen would induce fetal programming that may increase the risk of PCOS development during the adult life. By means of a prenatally hyperandrogenized (HA) rat model we demonstrated the importance of determining the lipid profile at early ages. HA induced two different phenotypes: ovulatory and anovulatory PCOS. HA did not modify total cholesterol but decreased HDL cholesterol and increased both LDL and tryglicerides (TG) when compared with controls. Both, the ratio total cholesterol: HDL (marker of cardiovascular risk) and TG:HDL (marker of metabolic syndrome) were increased in the HA group with respect to controls. In addition, these abnormalities were stronger in the anovulatory than ovulatory phenotype. Our results point out the need to find early markers of PCOS in girls or adolescents with increased risk to develop PCOS (as in daughters of women with PCOS).
authors.affiliation: Laboratorio de Fisiopatología Ovárica, Centro de Estudios Farmacológicos y Botánicos (CEFYBO), UBA-CONICET, Buenos Aires, Argentina.
authors.forename: María F
authors.initials: MF
authors.lastname: Heber
authors.forename: Leandro M
authors.initials: LM
authors.lastname: Vélez
authors.forename: Silvana R
authors.initials: SR
authors.lastname: Ferreira
authors.forename: Sabrina
authors.initials: S
authors.lastname: Amalfi
authors.forename: Alicia B
authors.initials: AB
authors.lastname: Motta
mesh_terms: D000818:Animals; D015415:Biomarkers / Q000097:blood; D008076:Cholesterol, HDL / Q000097:blood*; D008078:Cholesterol, LDL / Q000097:blood*; D004195:Disease Models, Animal; D005260:Female; D017588:Hyperandrogenism / Q000150:complications / Q000378:metabolism*; D007333:Insulin Resistance; D010641:Phenotype; D011085:Polycystic Ovary Syndrome / Q000209:etiology / Q000378:metabolism*; D011247:Pregnancy; D051381:Rats; D017207:Rats, Sprague-Dawley; D012307:Risk Factors
chemical_list: D015415:Biomarkers; D008076:Cholesterol, HDL; D008078:Cholesterol, LDL