title: A quantitative genetic and epigenetic model of complex traits.
abstract: BACKGROUND
  Despite our increasing recognition of the mechanisms that specify and propagate epigenetic states of gene expression, the pattern of how epigenetic modifications contribute to the overall genetic variation of a phenotypic trait remains largely elusive.
  
  
  RESULTS
  We construct a quantitative model to explore the effect of epigenetic modifications that occur at specific rates on the genome. This model, derived from, but beyond, the traditional quantitative genetic theory that is founded on Mendel's laws, allows questions concerning the prevalence and importance of epigenetic variation to be incorporated and addressed.
  
  
  CONCLUSIONS
  It provides a new avenue for bringing chromatin inheritance into the realm of complex traits, facilitating our understanding of the means by which phenotypic variation is generated.
authors.affiliation: Siyang Science and Technology Station, Yuanpeng Institute of Genome, Nantong, Jiangsu 226019, China.
authors.forename: Zhong
authors.initials: Z
authors.lastname: Wang
authors.forename: Zuoheng
authors.initials: Z
authors.lastname: Wang
authors.forename: Jianxin
authors.initials: J
authors.lastname: Wang
authors.forename: Yihan
authors.initials: Y
authors.lastname: Sui
authors.forename: Jian
authors.initials: J
authors.lastname: Zhang
authors.forename: Duanping
authors.initials: D
authors.lastname: Liao
authors.forename: Rongling
authors.initials: R
authors.lastname: Wu
mesh_terms: D003198:Computer Simulation; D044127:Epigenesis, Genetic; D014644:Genetic Variation; D016678:Genome; D006801:Humans; D008957:Models, Genetic; D020412:Multifactorial Inheritance / Q000235:genetics*