title: Evaluation of early atherosclerosis markers in patients with nonalcoholic fatty liver disease.
abstract: OBJECTIVE
  Nonalcoholic fatty liver disease (NAFLD) is characterized by the excessive accumulation of fat in the liver cells. It is strongly associated with cardiovascular risk factors for atherosclerosis. Flow-mediated dilation (FMD) and carotid intima-media thickness (CIMT) are noninvasive methods for the evaluation of endothelium. They are considered early markers of atherogenesis. The aim of this study was to evaluate early atherosclerosis markers in patients with NAFLD.
  
  
  METHODS
  We examined 161 patients. All the patients underwent hepatic ultrasonography, transthoracic echocardiography, and brachial artery and carotid artery imaging. Fasting blood samples were drawn from all patients for the determination of lipids, insulin, C-peptide, and fasting blood glucose. HOMA-IR was calculated.
  
  
  RESULTS
  Among the 161 patients, 44 had normal hepatic ultrasonography, 42 had stage 1 hepatosteatosis, 53 had stage 2 hepatosteatosis and 22 had stage 3 hepatosteatosis. FMD was reduced in patients with NAFLD as compared with the healthy controls (5.9 ± 3.1 vs. 9.6 ± 2.7%, P<0.001). There was a significant negative moderate correlation between ultrasonographic hepatosteatosis grade and FMD (r=-0.556, P<0.001). The mean CIMT was significantly increased in patients with NAFLD as compared with the controls (0.40 ± 0.19 vs. 0.27 ± 0.18, P<0.001). There was a significant positive weak correlation between ultrasonographic hepatosteatosis grade and mean CIMT (r=0.376, P<0.001).
  
  
  CONCLUSIONS
  This study showed that NAFLD is associated with impaired CIMT and FMD, which are early markers of atherosclerosis. These findings may play a crucial role in understanding the pathophysiology of the atherosclerotic process in patients with NAFLD.
authors.affiliation: Department of Internal Medicine, Division of Gastroenterology, Kecioren Teaching and Research Hospital, Ankara, Turkey. drmetingastromd@gmail.com
authors.forename: Metin
authors.initials: M
authors.lastname: Kucukazman
authors.forename: Naim
authors.initials: N
authors.lastname: Ata
authors.forename: Bunyamin
authors.initials: B
authors.lastname: Yavuz
authors.forename: Kursat
authors.initials: K
authors.lastname: Dal
authors.forename: Omer
authors.initials: O
authors.lastname: Sen
authors.forename: Onur S
authors.initials: OS
authors.lastname: Deveci
authors.forename: Kadir
authors.initials: K
authors.lastname: Agladioglu
authors.forename: Abdullah O
authors.initials: AO
authors.lastname: Yeniova
authors.forename: Yaşar
authors.initials: Y
authors.lastname: Nazligul
authors.forename: Derun T
authors.initials: DT
authors.lastname: Ertugrul
mesh_terms: D000328:Adult; D050197:Atherosclerosis / Q000097:blood / Q000000981:diagnostic imaging / Q000209:etiology*; D015415:Biomarkers / Q000097:blood; D001916:Brachial Artery / Q000000981:diagnostic imaging / Q000503:physiopathology; D059168:Carotid Intima-Media Thickness; D016022:Case-Control Studies; D004730:Endothelium, Vascular / Q000000981:diagnostic imaging / Q000503:physiopathology; D005234:Fatty Liver / Q000097:blood / Q000150:complications* / Q000000981:diagnostic imaging; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D065626:Non-alcoholic Fatty Liver Disease; D012307:Risk Factors; D014664:Vasodilation / Q000502:physiology
chemical_list: D015415:Biomarkers