title: Molecular genetic characterization of a cluster in A. terreus for biosynthesis of the meroterpenoid terretonin.
abstract: Meroterpenoids are natural products produced from polyketide and terpenoid precursors. A gene targeting system for A. terreus NIH2624 was developed, and a gene cluster for terretonin biosynthesis was characterized. The intermediates and shunt products were isolated from the mutant strains, and a pathway for terretonin biosynthesis is proposed. Analysis of two meroterpenoid pathways corresponding to terretonin in A. terreus and austinol in A. nidulans reveals that they are closely related evolutionarily.
authors.affiliation: Department of Pharmacology and Pharmaceutical Sciences, School of Pharmacy, University of Southern California, Los Angeles, California 90089, USA.
authors.forename: Chun-Jun
authors.initials: CJ
authors.lastname: Guo
authors.forename: Benjamin P
authors.initials: BP
authors.lastname: Knox
authors.forename: Yi-Ming
authors.initials: YM
authors.lastname: Chiang
authors.forename: Hsien-Chun
authors.initials: HC
authors.lastname: Lo
authors.forename: James F
authors.initials: JF
authors.lastname: Sanchez
authors.forename: Kuan-Han
authors.initials: KH
authors.lastname: Lee
authors.forename: Berl R
authors.initials: BR
authors.lastname: Oakley
authors.forename: Kenneth S
authors.initials: KS
authors.lastname: Bruno
authors.forename: Clay C C
authors.initials: CC
authors.lastname: Wang
mesh_terms: D001233:Aspergillus nidulans / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D015394:Molecular Structure; D013729:Terpenes / Q000737:chemistry*
chemical_list: D013729:Terpenes; C543993:terretonin F; C573071:austinol