title: Clinical characteristics of patients with Mycoplasma pneumoniae-related acute hepatitis.
abstract: OBJECTIVE
  Although the hepatobiliary manifestations of Mycoplasma pneumoniae infection have been described in several previous studies, controversies still remain. The aim of this study was to evaluate the clinical characteristics of patients with M. pneumoniae-related hepatitis and compare to those with M. pneumoniae infection but not hepatitis.
  
  
  METHODS
  We reviewed the medical chart of patients diagnosed with M. pneumoniae infection serologically.
  
  
  RESULTS
  Among the 117 patients with M. pneumoniae infection enrolled in the study, 25 showed acute hepatitis without any evidence of another cause. Patients with hepatitis presented with prodromal symptoms more frequently and also had a higher body temperature and C-reactive protein (CRP) levels than patients without hepatitis. Frequencies of respiratory tract involvement were not different between two groups. Clinical signs recovered within three weeks in both groups following the institution of antibiotic therapy. Multivariate analysis revealed that male sex, age <40 years, and high CRP levels were significantly linked to M. pneumoniae-related hepatitis.
  
  
  CONCLUSIONS
  We found that acute hepatitis associated with M. pneumoniae occurred in about 21% of all M. pneumoniae infections, and gender, age, and CRP levels were factors related to the occurrence of M. pneumoniae-related hepatitis.
authors.affiliation: Department of Internal Medicine, Hallym University Medical Center, Seoul, Korea.
authors.forename: Su Rin
authors.initials: SR
authors.lastname: Shin
authors.forename: Sang Hoon
authors.initials: SH
authors.lastname: Park
authors.forename: Joo-Hee
authors.initials: JH
authors.lastname: Kim
authors.forename: Jun-Wook
authors.initials: JW
authors.lastname: Ha
authors.forename: Yu Jin
authors.initials: YJ
authors.lastname: Kim
authors.forename: Sung Won
authors.initials: SW
authors.lastname: Jung
authors.forename: Jin Bae
authors.initials: JB
authors.lastname: Kim
authors.forename: Myung Seok
authors.initials: MS
authors.lastname: Lee
authors.forename: Choong Kee
authors.initials: CK
authors.lastname: Park
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D000410:Alanine Transaminase / Q000097:blood; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D001831:Body Temperature; D002097:C-Reactive Protein / Q000378:metabolism; D002648:Child; D005260:Female; D006505:Hepatitis / Q000097:blood / Q000188:drug therapy / Q000382:microbiology*; D006801:Humans; D018942:Macrolides / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D009175:Mycoplasma Infections / Q000150:complications* / Q000188:drug therapy; D009177:Mycoplasma pneumoniae; D012189:Retrospective Studies; D012737:Sex Factors; D055815:Young Adult
chemical_list: D000900:Anti-Bacterial Agents; D018942:Macrolides; D002097:C-Reactive Protein; D000410:Alanine Transaminase