title: Monotonous diets protect against acute colitis in mice: epidemiologic and therapeutic implications.
abstract: OBJECTIVE
  Multiple characteristics of industrialization have been proposed to contribute to the global emergence of inflammatory bowel diseases (IBDs: Crohn disease and ulcerative colitis). Major changes in eating habits during the last decades and the effectiveness of exclusive enteral nutrition in the treatment of Crohn disease indicate the etiologic importance of dietary intake in IBDs. A uniform characteristic of nutrition in developing countries (where the incidence of IBD is low) and exclusive enteral nutrition is their consistent nature for prolonged periods; however, the potentially beneficial effect of dietary monotony in respect to mammalian intestinal inflammation has not been examined.
  
  
  METHODS
  The association between alternating (2 different complete chows) and persistent regular diets, and dextran sulfate sodium colitis susceptibility in C57BL/6J mice was studied. Colonic mucosal microbiota changes were investigated by high-throughput pyrosequencing of the 16S rRNA gene.
  
  
  RESULTS
  The severity of colitis increased upon dietary alternation compared with consistent control feeding. The microbiota of the alternating nutritional group clustered discretely from both control groups.
  
  
  CONCLUSIONS
  Our findings highlight that monotonous dietary intake may decrease mammalian vulnerability against colitis in association with microbiota separation. The epidemiologic and therapeutic implications of our results are also discussed.
authors.affiliation: Department of Pediatrics, Baylor College of Medicine, USDA/ARS Children's Nutrition Research Center, Texas Children's Hospital, Houston, TX 77030-2399, USA.
authors.forename: Dorottya
authors.initials: D
authors.lastname: Nagy-Szakal
authors.forename: Sabina A V
authors.initials: SA
authors.lastname: Mir
authors.forename: Matthew C
authors.initials: MC
authors.lastname: Ross
authors.forename: Nina
authors.initials: N
authors.lastname: Tatevian
authors.forename: Joseph F
authors.initials: JF
authors.lastname: Petrosino
authors.forename: Richard
authors.initials: R
authors.lastname: Kellermayer
mesh_terms: D000208:Acute Disease; D000818:Animals; D003092:Colitis / Q000209:etiology / Q000382:microbiology / Q000517:prevention & control*; D003106:Colon / Q000382:microbiology* / Q000473:pathology; D016264:Dextran Sulfate; D004032:Diet / Q000009:adverse effects; D005798:Genes, Bacterial; D015212:Inflammatory Bowel Diseases / Q000209:etiology / Q000382:microbiology / Q000517:prevention & control*; D007413:Intestinal Mucosa / Q000382:microbiology*; D008297:Male; D054892:Metagenome; D051379:Mice; D008810:Mice, Inbred C57BL; D009747:Nutritional Physiological Phenomena; D012336:RNA, Ribosomal, 16S / Q000235:genetics; D012720:Severity of Illness Index
chemical_list: D012336:RNA, Ribosomal, 16S; D016264:Dextran Sulfate