title: End-binding proteins and Ase1/PRC1 define local functionality of structurally distinct parts of the microtubule cytoskeleton.
abstract: The microtubule cytoskeleton is crucial for the intracellular organization of eukaryotic cells. It is a dynamic scaffold that has to perform a variety of very different functions. This multitasking is achieved through the activity of numerous microtubule-associated proteins. Two prominent classes of proteins are central to the selective recognition of distinct transiently existing structural features of the microtubule cytoskeleton. They define local functionality through tightly regulated protein recruitment. Here we summarize the recent developments in elucidating the molecular mechanism underlying the action of microtubule end-binding proteins (EBs) and antiparallel microtubule crosslinkers of the Ase1/PRC1 family that represent the core of these two recruitment modules. Despite their fundamentally different activities, these conserved families share several common features.
authors.affiliation: London Research Institute, Cancer Research UK, 44 Lincoln's Inn Fields, London WC2A 3LY, UK.
authors.forename: Christian
authors.initials: C
authors.lastname: Duellberg
authors.forename: Franck J
authors.initials: FJ
authors.lastname: Fourniol
authors.forename: Sebastian P
authors.initials: SP
authors.lastname: Maurer
authors.forename: Johanna
authors.initials: J
authors.lastname: Roostalu
authors.forename: Thomas
authors.initials: T
authors.lastname: Surrey
mesh_terms: D000818:Animals; D002352:Carrier Proteins / Q000378:metabolism; D043402:Cathepsin A / Q000378:metabolism*; D002465:Cell Movement; D016764:Cell Polarity; D003599:Cytoskeleton / Q000378:metabolism*; D008869:Microtubule-Associated Proteins / Q000378:metabolism*; D008870:Microtubules / Q000378:metabolism*; D008938:Mitosis; D010766:Phosphorylation; D011485:Protein Binding; D025941:Protein Interaction Mapping; D029701:Saccharomyces cerevisiae Proteins / Q000378:metabolism*; D029702:Schizosaccharomyces pombe Proteins / Q000378:metabolism*; D008941:Spindle Apparatus; D013329:Structure-Activity Relationship; D015003:Yeasts / Q000378:metabolism
chemical_list: C502827:Ase1 protein, S pombe; D002352:Carrier Proteins; D008869:Microtubule-Associated Proteins; D029701:Saccharomyces cerevisiae Proteins; D029702:Schizosaccharomyces pombe Proteins; D043402:Cathepsin A; C499283:PRC1 protein, S cerevisiae