title: Microarray analysis of gene expression in mouse (strain 129) embryonic stem cells after typical synthetic musk exposure.
abstract: Synthetic musks are widely used in personal-care products and can readily accumulate in the adipose tissue, breast milk, and blood of humans. In this study, the Affymetrix Mouse Genome GeneChip was used to identify alterations in gene expression of embryonic stem cells from the 129 strain of the laboratory mouse after treatment with the synthetic musk tonalide (AHTN). Among the 45,037 transcripts in the microarray, 2,879 genes were differentially expressed. According to the microarray analysis, the potential influence of AHTN on the development to embryo should be of concern, and the toxicological effects of it and related musk compounds should be studied further.
authors.affiliation: Beijing Key Laboratory of Diagnostic and Traceability Technologies for Food Poisoning, Beijing Center for Disease Control and Prevention, Beijing, 100013, China.
authors.forename: Jiachen
authors.initials: J
authors.lastname: Shi
authors.forename: Ming
authors.initials: M
authors.lastname: Li
authors.forename: Zhihao
authors.initials: Z
authors.lastname: Jiao
authors.forename: Jing
authors.initials: J
authors.lastname: Zhang
authors.forename: Yixing
authors.initials: Y
authors.lastname: Feng
authors.forename: Bing
authors.initials: B
authors.lastname: Shao
mesh_terms: D000393:Air Pollutants / Q000633:toxicity*; D016902:Air Pollution, Indoor; D000818:Animals; D053595:Embryonic Stem Cells / Q000187:drug effects / Q000378:metabolism*; D005786:Gene Expression Regulation / Q000187:drug effects*; D051379:Mice; D057507:Mice, 129 Strain; D020411:Oligonucleotide Array Sequence Analysis; D010476:Perfume / Q000633:toxicity*; D013764:Tetrahydronaphthalenes / Q000633:toxicity*
chemical_list: D000393:Air Pollutants; D010476:Perfume; D013764:Tetrahydronaphthalenes; C033116:acetyl methyl tetramethyl tetralin