title: An efficient and novel approach for the synthesis of substituted N-aryl lactams.
abstract: A quick, efficient, one-pot method for the synthesis of substituted N-aryl lactams through the reaction of various kinds of corresponding substituted arenes with a variety of ω-azido alkanoic acid chlorides using a Lewis acid (i.e. EtAlCl(2)) at room temperature, through the in situ involvement of a Friedel-Crafts reaction followed by intramolecular Schimdt rearrangement was developed, and afforded good to excellent yields.
authors.affiliation: Laboratory of Medicinal Chemistry, Amity Institute of Pharmacy, Amity University Uttar Pradesh, Lucknow Campus, Lucknow-226010, UP, India. devduttchaturvedi@gmail.com
authors.forename: Devdutt
authors.initials: D
authors.lastname: Chaturvedi
authors.forename: Amit K
authors.initials: AK
authors.lastname: Chaturvedi
authors.forename: Nisha
authors.initials: N
authors.lastname: Mishra
authors.forename: Virendra
authors.initials: V
authors.lastname: Mishra
mesh_terms: D002264:Carboxylic Acids / Q000737:chemistry*; D002384:Catalysis; D002712:Chlorides; D007769:Lactams / Q000138:chemical synthesis*; D058116:Lewis Acids / Q000737:chemistry*; D047028:Macrocyclic Compounds / Q000737:chemistry*; D015394:Molecular Structure; D013237:Stereoisomerism; D013696:Temperature
chemical_list: D002264:Carboxylic Acids; D002712:Chlorides; D007769:Lactams; D058116:Lewis Acids; D047028:Macrocyclic Compounds