title: Oral chronic graft-versus-host disease: current pathogenesis, therapy, and research.
abstract: Optimal management of complex autoimmune diseases requires a multidisciplinary medical team including dentists to care for lesions of the oral cavity. In this review, we discuss the presentation, prevalence, diagnosis, and treatment of oral manifestations in chronic graft-versus-host disease (cGVHD), which is a major late complication in patients treated by allogeneic hematopoietic stem cell transplantation. We assess current general knowledge of systemic and oral cGVHD and present general treatment recommendations based on literature review and our clinical experience. Additionally, we review areas where the understanding of oral cGVHD could be improved by further research and address tools with which to accomplish the long-term goal of providing better health and quality of life to patients with cGVHD.
authors.affiliation: Clinical Research Core, National Institute of Dental and Craniofacial Research, Bethesda, MD 20892-4320, USA. maysjw@mail.nih.gov
authors.forename: J W
authors.initials: JW
authors.lastname: Mays
authors.forename: H
authors.initials: H
authors.lastname: Fassil
authors.forename: D A
authors.initials: DA
authors.lastname: Edwards
authors.forename: S Z
authors.initials: SZ
authors.lastname: Pavletic
authors.forename: C W
authors.initials: CW
authors.lastname: Bassim
mesh_terms: D001327:Autoimmune Diseases / Q000188:drug therapy / Q000209:etiology; D001402:B-Lymphocytes / Q000502:physiology; D002294:Carcinoma, Squamous Cell / Q000209:etiology; D002908:Chronic Disease; D003713:Dendritic Cells / Q000502:physiology; D006086:Graft vs Host Disease / Q000150:complications / Q000188:drug therapy / Q000209:etiology / Q000276:immunology / Q000473:pathology; D018380:Hematopoietic Stem Cell Transplantation / Q000009:adverse effects*; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D009059:Mouth Diseases / Q000150:complications / Q000188:drug therapy / Q000209:etiology / Q000276:immunology / Q000473:pathology; D009061:Mouth Mucosa / Q000473:pathology; D009062:Mouth Neoplasms / Q000209:etiology; D016059:Range of Motion, Articular; D012469:Salivary Glands / Q000473:pathology; D012471:Salivary Proteins and Peptides / Q000502:physiology; D013601:T-Lymphocytes / Q000502:physiology; D014987:Xerostomia / Q000209:etiology
chemical_list: D007166:Immunosuppressive Agents; D012471:Salivary Proteins and Peptides