title: 12S-hydroxyeicosatetraenoic acid levels link to coronary artery disease in Type 2 diabetic patients.
abstract: BACKGROUND
  12(S)-Hydroxyeicosatetraenoic acid (12(S)-HETE) is a metabolite of arachidonic acid. 12(S)-HETE is involved in the pathogenesis of atherosclerosis and diabetes. However, the correlation between 12(S)-HETE and coronary artery disease (CAD) in the diabetic patient is unclear.
  
  
  OBJECTIVE
  The study investigated the relationship between 12(S)-HETE and CAD in Type 2 diabetes (T2D).
  
  
  METHODS
  Plasma 12(S)- HETE levels were detected by enzyme-linked immunosorbent assay in 103 healthy controls (control), 109 diabetic patients without CAD (diabetic), and 152 diabetic patients with CAD (diabetic-CAD).
  
  
  RESULTS
  12(S)-HETE levels were higher in both diabetic and diabetic-CAD groups compared to control and in the diabetic-CAD group compared to the diabetic group. In the multiple linear stepwise regression analysis, 12(S)-HETE levels correlated independently with CAD, systolic blood pressure, and glycated hemoglobin.
  
  
  CONCLUSIONS
  These results indicate that 12(S)-HETE levels are increased in diabetic patients with CAD, suggesting a role for atherosclerosis in T2D.
authors.affiliation: Department of Endocrinology, First Affiliated Hospital of Harbin Medical University, Harbin, China.
authors.forename: H J
authors.initials: HJ
authors.lastname: Zhang
authors.forename: C H
authors.initials: CH
authors.lastname: Sun
authors.forename: H Y
authors.initials: HY
authors.lastname: Kuang
authors.forename: X Y
authors.initials: XY
authors.lastname: Jiang
authors.forename: H L
authors.initials: HL
authors.lastname: Liu
authors.forename: W F
authors.initials: WF
authors.lastname: Hua
authors.forename: Z J
authors.initials: ZJ
authors.lastname: Liu
authors.forename: H
authors.initials: H
authors.lastname: Zhou
authors.forename: H
authors.initials: H
authors.lastname: Sui
authors.forename: R
authors.initials: R
authors.lastname: Qi
mesh_terms: D019377:12-Hydroxy-5,8,10,14-eicosatetraenoic Acid / Q000097:blood*; D000328:Adult; D000368:Aged; D001794:Blood Pressure / Q000502:physiology; D016022:Case-Control Studies; D003324:Coronary Artery Disease / Q000097:blood* / Q000453:epidemiology / Q000209:etiology / Q000503:physiopathology; D003924:Diabetes Mellitus, Type 2 / Q000097:blood* / Q000150:complications / Q000453:epidemiology / Q000503:physiopathology; D003925:Diabetic Angiopathies / Q000097:blood* / Q000453:epidemiology / Q000209:etiology / Q000503:physiopathology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012044:Regression Analysis; D012307:Risk Factors
chemical_list: D019377:12-Hydroxy-5,8,10,14-eicosatetraenoic Acid