title: Sjogren's syndrome with distal renal tubular acidosis presenting as hypokalaemic paralysis.
abstract: A young lady with a history of repeated episodes of generalised weakness and fatigue presented to our hospital with similar symptoms and was found to have severe hypokalaemia. She had been previously diagnosed as hypokalaemic periodic paralysis but during this presentation she had also started complaining of the classic sicca-complex of Sjogren's syndrome, which was not present previously. On subsequent investigations she was found to have normal anion-gap metabolic acidosis with positive urine anion gap consistent with the diagnosis of distal renal tubular acidosis (RTA). It was thus concluded that the distal RTA secondary to Sjogren's syndrome was the cause of severe hypokalaemia in our patient. By presenting this case we aim to not only highlight one of the rare presentations of Sjogren's syndrome but also the favourable response of our patient to potassium replacement alone.
authors.affiliation: Department of Medicine, Grant Medical College and Sir JJ Group of Hospitals, Mumbai, Maharashtra, India. gaurang2489@gmail.com
authors.forename: Gaurang
authors.initials: G
authors.lastname: Vaidya
authors.forename: Swapnil
authors.initials: S
authors.lastname: Ganeshpure
mesh_terms: D000141:Acidosis, Renal Tubular / Q000150:complications* / Q000175:diagnosis; D000328:Adult; D005260:Female; D006801:Humans; D007008:Hypokalemia / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology*; D020514:Hypokalemic Periodic Paralysis / Q000150:complications / Q000175:diagnosis; D010243:Paralysis / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology*; D011188:Potassium / Q000627:therapeutic use*; D012859:Sjogren's Syndrome / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy; D014131:Trace Elements / Q000627:therapeutic use*; D055815:Young Adult
chemical_list: D014131:Trace Elements; D011188:Potassium