title: Carbon dioxide (CO₂) ablation as a remedy for hepatocellular carcinoma.
abstract: OBJECTIVE
  The purpose of this research was to investigate the application of carbon dioxide (CO₂) ablation and determine if carbon dioxide plays a role in treating hepatocellular carcinoma.
  
  
  METHODS
  Twelve mice with subcutaneous xenografts of a hepatocellular cancer cell line were randomly separated into 2 groups. One group underwent CO₂ ablation with their liver tumor in vivo while the other group in vitro, respectively. All mice were killed on day 28. Hematoxylin-eosin (HE) staining was performed on the mice to estimate the pathological change.
  
  
  RESULTS
  Just after 4 weeks, no significant difference in tumor size was detected between the two groups. The dimensions of the principal tumor varied from 2-3 cm with an average size of 2.2 cm in the greatest dimension. HE staining demonstrated an array of construct damage and necrosis in both groups.
  
  
  CONCLUSIONS
  CO₂ ablation could be an important treatment in the management of cancer.
authors.affiliation: College of Power Engineering, Chongqing University, Chongqing, China.
authors.forename: Dong-Yi
authors.initials: DY
authors.lastname: Liang
authors.forename: Shi-Chun
authors.initials: SC
authors.lastname: Zhou
authors.forename: Hongyu
authors.initials: H
authors.lastname: Zhou
authors.forename: Mingwei
authors.initials: M
authors.lastname: Tong
mesh_terms: D000818:Animals; D002245:Carbon Dioxide / Q000627:therapeutic use*; D006528:Carcinoma, Hepatocellular / Q000473:pathology / Q000601:surgery*; D017115:Catheter Ablation / Q000379:methods*; D008113:Liver Neoplasms / Q000473:pathology / Q000601:surgery*; D051379:Mice; D008807:Mice, Inbred BALB C
chemical_list: D002245:Carbon Dioxide