title: Effect of low-dose omega-3 fatty acids substitution on blood pressure, hyperinsulinemia and dyslipidemia in Indians with essential hypertension: A pilot study.
abstract: The present study comprised 100 patients of essential hypertension who were screened for fasting hyperinsulinemia, which was detected in 77% cases. Twenty such hyperinsulinemic cases were subjected to 4 weeks of dietary control phase followed by 6 weeks of omega-3 fatty acids substitution [either 0.6 g/d (group 1) or 1.2 g/d (group 2)]. The mean basal fasting plasma insulin levels were significantly higher (p<0.001) in patients of hypertension when compared to normal controls (126.51±80.36 and 19.35±12.61 μU/ml respectively). At the end of 4 weeks of diet control only, no significant change was observed in any parameter. After substitution of omega-3 fatty acid, a significant reduction of fasting plasma insulin levels in both group 1 (29%) and group 2 (22.8%) was observed (p<0.001). Significant reduction of systolic and diastolic blood pressure (16.4% and 25% respectively), serum cholesterol, triglycerides and low density lipoprotein was also noted in both groups (p<0.001), while high density lipoprotein increased by ∼8 mg% in both groups. Thus omega-3 fatty acid substituion in low dose along-with curtailment of dietary omega-6 fatty acid may be used as an adjunctive measure in the management of essential hypertension.
authors.affiliation: Department of Medicine, Maulana Azad Medical College and Lok Nayak Hospital, New Delhi.
authors.forename: A
authors.initials: A
authors.lastname: Bhise
authors.forename: P V
authors.initials: PV
authors.lastname: Krishnan
authors.forename: R
authors.initials: R
authors.lastname: Aggarwal
authors.forename: M
authors.initials: M
authors.lastname: Gaiha
authors.forename: J
authors.initials: J
authors.lastname: Bhattacharjee
keywords: Essential hypertension; Hyperinsulinemia; Omega-3 Fatty acids