title: Intraosseous inoculation of tumor cells into bone marrow promotes distant metastatic tumor development: A novel tool for mechanistic and therapeutic studies.
abstract: Bone marrow-derived cells have a potent impact on the formation and progression of tumor metastasis. This study demonstrates that bone marrow directly promotes metastasis to distant sites from tumor cells residing in the bone marrow in multiple types of tumors and multiple mouse strains. The bone marrow environment requires less tumor cells for inducing distant metastasis and overcomes the inhibition of metastasis resulting from engineering the tumor cells with reporter genes. This discovery provides an effective approach to generate spontaneous-like metastatic tumor models which will satisfy the urgent need for studying metastasis biology and discovering novel therapeutics.
authors.affiliation: The University of Texas MD Anderson Cancer Center, Department of Pediatrics, 1515 Holcombe Blvd., Houston, TX 77030, United States.
authors.forename: Jeffry
authors.initials: J
authors.lastname: Cutrera
authors.forename: Blake
authors.initials: B
authors.lastname: Johnson
authors.forename: Lee
authors.initials: L
authors.lastname: Ellis
authors.forename: Shulin
authors.initials: S
authors.lastname: Li
mesh_terms: D000230:Adenocarcinoma / Q000235:genetics / Q000473:pathology; D000818:Animals; D001853:Bone Marrow / Q000473:pathology*; D001943:Breast Neoplasms / Q000235:genetics / Q000473:pathology; D045744:Cell Line, Tumor; D003110:Colonic Neoplasms / Q000473:pathology; D004195:Disease Models, Animal; D004333:Drug Administration Routes; D005260:Female; D017930:Genes, Reporter; D007938:Leukemia / Q000473:pathology; D008156:Luciferases / Q000235:genetics; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D009362:Neoplasm Metastasis / Q000503:physiopathology*; D009447:Neuroblastoma / Q000473:pathology
chemical_list: D008156:Luciferases