title: Effect of spironolactone on acid and alkaline phosphatase in the testes of albino rat.
abstract: The biological activity of the mineralocorticoid antagonist, spironolactone depend upon its metabolism. In this study the effect of diuretic drug compound spironolactone on the acid and alkaline phosphatase in the testes of albino rat. The drug spironolactone was administered orally daily for 7(th), 14(th) and 21(st) days at the dose of 100 mg/kg body weight. Among them, the side effects of drug are that the degradation of alkaline phosphatase in the testes; while acid phosphatase increased significantly may be due to 7a-thiospironolactone is a tissue metabolite of spironolactone and may contribute to the testicular enzymes, therapeutic actions and some other side effects. It is suggested that the decrease and increase of alkaline and acid phosphatase in the testes of albino rat are the due to the side effects of spironolactone drug compound.
authors.affiliation: Department of Zoology, School of Life Sciences, Dr. B. R. Ambedkar University, Khandari Campus, 282002 Agra, (India).
authors.forename: P K
authors.initials: PK
authors.lastname: Singh
authors.forename: D P
authors.initials: DP
authors.lastname: Singh
keywords: Acid and Alkaline Phosphatase; Albino rat; Drug Spironolactone