title: No association between MTHFR A1298C gene polymorphism and head and neck cancer risk: a meta-analysis based on 9,952 subjects.
abstract: OBJECTIVE
  Findings for associations between the methylenetetrahydrofolate reductase (MTHFR) A1298C gene polymorphism and head and neck cancer risk have been conflicting. We therefore performed a meta-analysis to derive a more precise relationship.
  
  
  METHODS
  Ten published case-control studies were collected and odds ratios (ORs) with 95% confidence intervals (CIs) were used to assess the association between MTHFR A1298C polymorphism and head and neck cancer risk. Sensitivity analysis and publication bias assessment also were performed to guarantee the statistical power.
  
  
  RESULTS
  Overall, no significant association between MTHFR A1298C polymorphism and head and neck cancer risk was found in this meta-analysis (C vs. A: OR=1.04, 95%CI=0.87- 1.25, P=0.668, P heterogeneity<0.001; CC vs. AA: OR=1.07, 95%CI=0.70-1.65, P=0.748, P heterogeneity<0.001; AC vs. AA: OR=1.06, 95%CI=0.88-1.27, P=0.565, P heterogeneity<0.001; CC+AC vs. AA: OR=1.06, 95%CI=0.86-1.30, P=0.571, P heterogeneity<0.001; CC vs. AA+AC: OR=1.02, 95%CI=0.69-1.52, P=0.910, P heterogeneity<0.001). Similar results were also been found in succeeding analysis of HWE and stratified analysis of ethnicity.
  
  
  CONCLUSIONS
  In conclusion, our meta-analysis demonstrates that MTHFR A1298C polymorphism may not be a risk factor for developing head and neck cancer.
authors.affiliation: Department of Stomatology, Taihe Hospital, Hubei University of Medicine, Shiyan, China. niuyuming@yeah.net
authors.forename: Yu-Ming
authors.initials: YM
authors.lastname: Niu
authors.forename: Ming
authors.initials: M
authors.lastname: Shen
authors.forename: Hui
authors.initials: H
authors.lastname: Li
authors.forename: Xiao-Bing
authors.initials: XB
authors.lastname: Ni
authors.forename: Juan
authors.initials: J
authors.lastname: Zhou
authors.forename: Xian-Tao
authors.initials: XT
authors.lastname: Zeng
authors.forename: Wei-Dong
authors.initials: WD
authors.lastname: Leng
authors.forename: Ming-Yue
authors.initials: MY
authors.lastname: Wu
mesh_terms: D016022:Case-Control Studies; D020022:Genetic Predisposition to Disease; D006258:Head and Neck Neoplasms / Q000209:etiology*; D006801:Humans; D042965:Methylenetetrahydrofolate Reductase (NADPH2) / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D012307:Risk Factors
chemical_list: C573423:MTHFR protein, human; D042965:Methylenetetrahydrofolate Reductase (NADPH2)