title: Gene variants with suicidal risk in a sample of subjects with chronic migraine and affective temperamental dysregulation.
abstract: BACKGROUND
  Risk factors for suicide are at least partially heritable and functional polymorphisms of targeted genes have been suggested to be implicated in the pathogenesis of this phenomenon. However, other studies examining the association between specific gene variants and suicide revealed inconsistent findings. We aims to evaluate the possible association between MAO-A3, CYP1A2*1F and GNB3 gene variants, hopelessness and suicidal risk in a sample of subjects with chronic migraine and affective temperamental dysregulation.
  
  
  METHODS
  56 women were genotyped for MAO-A3, CYP1A2*1F and GNB3 gene variants. Participants were also assessed using Beck Hopelessness Scale (BHS), the Temperament Evaluation of the Memphis, Pisa, Paris and San Diego-Autoquestionnaire (TEMPS-A), and the Suicidal History Self-Rating Screening Scale (SHSS).
  
  
  RESULTS
  Patients with higher total scores on affective dysregulated temperaments are more likely to have higher BHS (11.27+/=5.54 vs. 5.73+/=3.81; t19.20 = -3.57; p < 0.01) and higher SHSS total scores (4.79+/=3.31 vs. 1.05±2.31; t17.74 = -3.90; p < 0.001) than those with lower total scores. 67% of patients in the dysregulated group has BHS total scores >= 9 indicating high levels of hopelessness. No association was found between MAO-A3, CYP1A2*1F and GNB3 gene variants and suicidal risk as assessed by BHS and SHSS.
  
  
  CONCLUSIONS
  This study did not sustain the association between MAO-A3, CYP1A2*1F and GNB3 gene variants and increased suicidal risk in patients with chronic migraine and affective temperamental dysregulation. Further studies investigating the gene-environment interaction or focusing on other genetic risk factors involved in suicidal behaviour are needed.
authors.affiliation: Department of Neurosciences, Mental Health and Sensory Functions, Suicide Prevention Center Sant'Andrea Hospital, Sapienza University of Rome, Italy.
authors.forename: G
authors.initials: G
authors.lastname: Serafini
authors.forename: M
authors.initials: M
authors.lastname: Pompili
authors.forename: M
authors.initials: M
authors.lastname: Innamorati
authors.forename: G
authors.initials: G
authors.lastname: Gentile
authors.forename: M
authors.initials: M
authors.lastname: Borro
authors.forename: D A
authors.initials: DA
authors.lastname: Lamis
authors.forename: N
authors.initials: N
authors.lastname: Lala
authors.forename: A
authors.initials: A
authors.lastname: Negro
authors.forename: M
authors.initials: M
authors.lastname: Simmaco
authors.forename: P
authors.initials: P
authors.lastname: Girardi
authors.forename: P
authors.initials: P
authors.lastname: Martelletti
mesh_terms: D000328:Adult; D000342:Affective Symptoms / Q000150:complications / Q000235:genetics*; D000368:Aged; D002908:Chronic Disease; D019388:Cytochrome P-450 CYP1A2 / Q000235:genetics; D005260:Female; D014644:Genetic Variation; D020962:Heterotrimeric GTP-Binding Proteins / Q000235:genetics; D006801:Humans; D008875:Middle Aged; D008881:Migraine Disorders / Q000150:complications / Q000235:genetics*; D008995:Monoamine Oxidase / Q000235:genetics; D012306:Risk; D013405:Suicide; D013694:Temperament
chemical_list: C454420:G-protein beta3 subunit; C504573:CYP1A2 protein, human; D019388:Cytochrome P-450 CYP1A2; D008995:Monoamine Oxidase; D020962:Heterotrimeric GTP-Binding Proteins