title: Pd-catalyzed tandem cyclization of ethyl glyoxalate and amines: rapid assembly of highly substituted cyclic dehydro-α-amino acid derivatives.
abstract: A novel cascade cyclization of ethyl glyoxalate and amines proceeds in the presence of Pd(TFA)(2) (5 mol %) to give the cyclic dehydro-α-amino acid derivatives. This method provides a fast and simple access to highly substituted dihydro-pyrrol-2-ones in good yields.
authors.affiliation: School of Chemistry and Chemical Engineering, South China University of Technology, No. 381, Wushan Road, Tianhe District, Guangzhou 510641, China.
authors.forename: Yueting
authors.initials: Y
authors.lastname: Luo
authors.forename: Xiaoxia
authors.initials: X
authors.lastname: Lu
authors.forename: Yong
authors.initials: Y
authors.lastname: Ye
authors.forename: Ya
authors.initials: Y
authors.lastname: Guo
authors.forename: Huanfeng
authors.initials: H
authors.lastname: Jiang
authors.forename: Wei
authors.initials: W
authors.lastname: Zeng
mesh_terms: D000588:Amines / Q000737:chemistry*; D000598:Amino Acids, Cyclic / Q000138:chemical synthesis* / Q000737:chemistry; D002384:Catalysis; D003500:Cyclization; D006038:Glyoxylates / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D010165:Palladium / Q000737:chemistry*
chemical_list: D000588:Amines; D000598:Amino Acids, Cyclic; D006038:Glyoxylates; C579385:ethyl glyoxalate; D010165:Palladium