title: Tyrosinase inhibitors from the wood of Artocarpus heterophyllus.
abstract: From the methanolic-soluble extract of the wood of Artocarpus heterophyllus, four new flavones, artocarmins A-D (1-4), and three new chalcones, artocarmitins A-C (5-7), have been isolated together with 13 known compounds. Their structures were determined on the basis of the spectroscopic data. Compounds 1-4, 6, 7, 9-16, and 20 displayed significant tyrosinase inhibitory activity. The most active compound, morachalcone A (12) (IC50, 0.013 μM), was 3000 times more active as a tyrosinase inhibitor than a positive control, kojic acid (IC50, 44.6 μM).
authors.affiliation: Faculty of Chemistry, University of Science, Vietnam National University-HoChiMinh City , 227 Nguyen Van Cu Street, District 5, HoChiMinh City, Vietnam.
authors.forename: Nhan Trung
authors.initials: NT
authors.lastname: Nguyen
authors.forename: Mai Ha Khoa
authors.initials: MH
authors.lastname: Nguyen
authors.forename: Hai Xuan
authors.initials: HX
authors.lastname: Nguyen
authors.forename: Ngan Kim Nguyen
authors.initials: NK
authors.lastname: Bui
authors.forename: Mai Thanh Thi
authors.initials: MT
authors.lastname: Nguyen
mesh_terms: D031622:Artocarpus / Q000737:chemistry*; D047188:Chalcones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D015394:Molecular Structure; D014442:Monophenol Monooxygenase / Q000037:antagonists & inhibitors*; D011753:Pyrones / Q000494:pharmacology; D014934:Wood / Q000737:chemistry
chemical_list: D047188:Chalcones; D011753:Pyrones; C587519:morachalcone A; C011890:kojic acid; D014442:Monophenol Monooxygenase