title: Difficult clinical management of anti-tuberculosis DRESS syndrome.
abstract: We describe 11 cases of anti-tuberculosis DRESS (drug-related rash with eosinophilia and systemic symptoms) syndrome, a potentially serious complication of treatment that led to interruption of treatment for prolonged periods, systemic corticosteroid use and the resumption of treatment  with less effective regimens. All patients had rash and toxic hepatitis, one died of multi-organ failure and, contrary to expectations, the evolution of tuberculosis (advanced in most cases) did not progress under corticosteroid treatment. The drug most frequently involved was rifampicin,  while retreatment schemes included, in most cases, levofloxacin, ethambutol, streptomycin and cycloserine.
authors.affiliation: División Tisioneumonología, Hospital de Infecciosas Dr F J Muñiz, Buenos Aires, Argentina. djpalmero@intramed.net
authors.forename: D
authors.initials: D
authors.lastname: Palmero
authors.forename: J
authors.initials: J
authors.lastname: Castagnino
authors.forename: R M
authors.initials: RM
authors.lastname: Musella
authors.forename: C
authors.initials: C
authors.lastname: Mosca
authors.forename: P
authors.initials: P
authors.lastname: González Montaner
authors.forename: G C
authors.initials: GC
authors.lastname: de Casado
mesh_terms: D000293:Adolescent; D000328:Adult; D000995:Antitubercular Agents / Q000009:adverse effects*; D056486:Chemical and Drug Induced Liver Injury / Q000209:etiology* / Q000628:therapy; D003875:Drug Eruptions / Q000209:etiology* / Q000628:therapy; D004802:Eosinophilia / Q000139:chemically induced* / Q000628:therapy; D005076:Exanthema / Q000139:chemically induced* / Q000628:therapy; D005260:Female; D006801:Humans; D008297:Male; D012189:Retrospective Studies; D013577:Syndrome; D055815:Young Adult
chemical_list: D000995:Antitubercular Agents