title: Fatty acid composition of adipose tissue triglycerides after weight loss and weight maintenance: the DIOGENES study.
abstract: Fatty acid composition of adipose tissue changes with weight loss. Palmitoleic acid as a possible marker of endogenous lipogenesis or its functions as a lipokine are under debate. Objective was to assess the predictive role of adipose triglycerides fatty acids in weight maintenance in participants of the DIOGENES dietary intervention study. After an 8-week low calorie diet (LCD) subjects with > 8 % weight loss were randomized to 5 ad libitum weight maintenance diets for 6 months: low protein (P)/low glycemic index (GI) (LP/LGI), low P/high GI (LP/HGI), high P/low GI (HP/LGI), high P/high GI (HP/HGI), and a control diet. Fatty acid composition in adipose tissue triglycerides was determined by gas chromatography in 195 subjects before the LCD (baseline), after LCD and weight maintenance. Weight change after the maintenance phase was positively correlated with baseline adipose palmitoleic (16:1n-7), myristoleic (14:1n-5) and trans-palmitoleic acid (16:1n-7t). Negative correlation was found with baseline oleic acid (18:1n-9). Lower baseline monounsaturated fatty acids (14:1n-5, 16:1n-7 and trans 16:1n-7) in adipose tissue triglycerides predict better weight maintenance. Lower oleic acid predicts lower weight decrease. These findings suggest a specific role of monounsaturated fatty acids in weight management and as weight change predictors.
authors.affiliation: Obesity Management Centre, Institute of Endocrinology, Prague, Czech Republic. mkunesova@endo.cz
authors.forename: M
authors.initials: M
authors.lastname: Kunešová
authors.forename: P
authors.initials: P
authors.lastname: Hlavatý
authors.forename: E
authors.initials: E
authors.lastname: Tvrzická
authors.forename: B
authors.initials: B
authors.lastname: Staňková
authors.forename: P
authors.initials: P
authors.lastname: Kalousková
authors.forename: N
authors.initials: N
authors.lastname: Viguerie
authors.forename: T M
authors.initials: TM
authors.lastname: Larsen
authors.forename: M A
authors.initials: MA
authors.lastname: van Baak
authors.forename: S A
authors.initials: SA
authors.lastname: Jebb
authors.forename: J A
authors.initials: JA
authors.lastname: Martinez
authors.forename: A F H
authors.initials: AF
authors.lastname: Pfeiffer
authors.forename: A
authors.initials: A
authors.lastname: Kafatos
authors.forename: T
authors.initials: T
authors.lastname: Handjieva-Darlenska
authors.forename: M
authors.initials: M
authors.lastname: Hill
authors.forename: D
authors.initials: D
authors.lastname: Langin
authors.forename: A
authors.initials: A
authors.lastname: Zák
authors.forename: A
authors.initials: A
authors.lastname: Astrup
authors.forename: W H M
authors.initials: WH
authors.lastname: Saris
mesh_terms: D000273:Adipose Tissue / Q000737:chemistry* / Q000378:metabolism; D000328:Adult; D001835:Body Weight; D005227:Fatty Acids / Q000737:chemistry* / Q000378:metabolism; D005229:Fatty Acids, Monounsaturated / Q000737:chemistry / Q000378:metabolism; D005260:Female; D038321:Glycemic Index; D006801:Humans; D008297:Male; D008875:Middle Aged; D019301:Oleic Acid / Q000737:chemistry / Q000378:metabolism; D014280:Triglycerides / Q000032:analysis / Q000378:metabolism*; D015431:Weight Loss / Q000502:physiology*
chemical_list: D005227:Fatty Acids; D005229:Fatty Acids, Monounsaturated; D014280:Triglycerides; C008757:palmitoleic acid; D019301:Oleic Acid; C054211:9-tetradecenoic acid