title: Diagnosis and treatment of overactive bladder (non-neurogenic) in adults: AUA/SUFU guideline.
abstract: OBJECTIVE
  The purpose of this guideline is to provide a clinical framework for the diagnosis and treatment of non-neurogenic overactive bladder (OAB).
  
  
  METHODS
  The primary source of evidence for this guideline is the systematic review and data extraction conducted as part of the Agency for Healthcare Research and Quality (AHRQ) Evidence Report/Technology Assessment Number 187 titled Treatment of Overactive Bladder in Women (2009). That report searched PubMed, MEDLINE®, EMBASE and CINAHL for English-language studies published from January 1966 to October 2008. The AUA conducted additional literature searches to capture treatments not covered in detail by the AHRQ report and relevant articles published between October 2008 and December 2011. The review yielded an evidence base of 151 treatment articles after application of inclusion/exclusion criteria. When sufficient evidence existed, the body of evidence for a particular treatment was assigned a strength rating of A (high), B (moderate) or C (low). Additional treatment information is provided as Clinical Principles and Expert Opinions when insufficient evidence existed.
  
  
  RESULTS
  The evidence-based guideline statements are provided for diagnosis and overall management of the adult with OAB symptoms as well as for various treatments. The panel identified first through third line treatments as well as non-FDA approved, rarely applicable and treatments that should not be offered.
  
  
  CONCLUSIONS
  The evidence-based statements are provided for diagnosis and overall management of OAB, as well as for the various treatments. Diagnosis and treatment methodologies can be expected to change as the evidence base grows and as new treatment strategies become obtainable.
authors.affiliation: American Urological Association Education and Research, Inc., Linthicum, Maryland, USA
authors.forename: E Ann
authors.initials: EA
authors.lastname: Gormley
authors.forename: Deborah J
authors.initials: DJ
authors.lastname: Lightner
authors.forename: Kathryn L
authors.initials: KL
authors.lastname: Burgio
authors.forename: Toby C
authors.initials: TC
authors.lastname: Chai
authors.forename: J Quentin
authors.initials: JQ
authors.lastname: Clemens
authors.forename: Daniel J
authors.initials: DJ
authors.lastname: Culkin
authors.forename: Anurag Kumar
authors.initials: AK
authors.lastname: Das
authors.forename: Harris Emilio
authors.initials: HE
authors.lastname: Foster
authors.forename: Harriette Miles
authors.initials: HM
authors.lastname: Scarpero
authors.forename: Christopher D
authors.initials: CD
authors.lastname: Tessier
authors.forename: Sandip Prasan
authors.initials: SP
authors.lastname: Vasavada
mesh_terms: D000328:Adult; D000465:Algorithms; D005260:Female; D006801:Humans; D053201:Urinary Bladder, Overactive / Q000175:diagnosis* / Q000628:therapy*