title: Neuronal circuits involving neuropeptide Y in hypothalamic arcuate nucleus-mediated feeding regulation.
abstract: Neuropeptide Y (NPY) is a 36-amino-acid neuropeptide that was first discovered in porcine brain extracts and later in the porcine intestine. It is widely distributed in both the central and peripheral nervous systems and exerts a powerful orexigenic effect. NPY-producing neuronal cell bodies are abundantly localized in the medial arcuate nucleus of the hypothalamus, this being a brain center that integrates signals for energy homeostasis. Accumulated evidence shows that hypothalamic neuropeptides such as ghrelin, orexin, melanin-concentrating hormone (MCH), galanin-like peptide (GALP) and proopiomelanocortin (POMC) are involved in the regulation of feeding behavior and energy homeostasis via neuronal circuits in the hypothalamus. NPY also forms part of the feeding-regulating neuronal circuitry in conjunction with other feeding-regulating peptide-containing neurons within the hypothalamus. We summarize here current knowledge of the neuronal interactions between NPY and the different types of feeding-regulating peptide-containing neurons in the hypothalamus based on evidence at the immunohistochemicl level and with calcium imaging techniques.
authors.affiliation: Faculty of Health Care, Kiryu University, Gunma 379-2392, Japan.
authors.forename: Haruaki
authors.initials: H
authors.lastname: Kageyama
authors.forename: Fumiko
authors.initials: F
authors.lastname: Takenoya
authors.forename: Satoshi
authors.initials: S
authors.lastname: Hirako
authors.forename: Nobuhiro
authors.initials: N
authors.lastname: Wada
authors.forename: Yuri
authors.initials: Y
authors.lastname: Kintaka
authors.forename: Shuji
authors.initials: S
authors.lastname: Inoue
authors.forename: Eiji
authors.initials: E
authors.lastname: Ota
authors.forename: Tetsuo
authors.initials: T
authors.lastname: Ogawa
authors.forename: Seiji
authors.initials: S
authors.lastname: Shioda
mesh_terms: D000818:Animals; D001111:Arcuate Nucleus of Hypothalamus / Q000502:physiology*; D004435:Eating / Q000502:physiology*; D019004:Galanin / Q000502:physiology; D054439:Ghrelin / Q000502:physiology; D006801:Humans; D007028:Hypothalamic Hormones / Q000502:physiology; D007150:Immunohistochemistry; D047908:Intracellular Signaling Peptides and Proteins / Q000502:physiology; D020738:Leptin / Q000502:physiology; D008543:Melanins / Q000502:physiology; D009474:Neurons / Q000502:physiology*; D009478:Neuropeptide Y / Q000502:physiology*; D009479:Neuropeptides / Q000502:physiology; D000068797:Orexins; D010907:Pituitary Hormones / Q000502:physiology; D015398:Signal Transduction / Q000502:physiology
chemical_list: D054439:Ghrelin; D007028:Hypothalamic Hormones; D047908:Intracellular Signaling Peptides and Proteins; D020738:Leptin; D008543:Melanins; D009478:Neuropeptide Y; D009479:Neuropeptides; D000068797:Orexins; D010907:Pituitary Hormones; C019463:melanin-concentrating hormone; D019004:Galanin