title: Synthesis of N-alkyl and N-aryl isoquinolones and derivatives via Pd-catalysed C-H activation and cyclization reactions.
abstract: Relatively less expensive Pd-catalysed oxidative coupling reactions for the preparation of N-alkyl and N-aryl substituted isoquinolones and their derivatives have been developed. A broad reaction scope has been demonstrated. In addition, studies of the reaction additives and mechanistic insights, as well as KIE studies for a better understanding of the reaction pathway, have been discussed.
authors.affiliation: Tianjin Key Laboratory for Modern Drug Delivery and High-Efficiency, School of Pharmaceutical Science and Technology, Tianjin University, 92 Weijin Road, Nankai District, Tianjin, China.
authors.forename: Nana
authors.initials: N
authors.lastname: Zhang
authors.forename: Binyao
authors.initials: B
authors.lastname: Li
authors.forename: Hongban
authors.initials: H
authors.lastname: Zhong
authors.forename: Jianhui
authors.initials: J
authors.lastname: Huang
mesh_terms: D002384:Catalysis; D003500:Cyclization; D015394:Molecular Structure; D010165:Palladium / Q000737:chemistry*; D015363:Quinolones / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D015363:Quinolones; D010165:Palladium