title: Deep brain stimulation effects on memory.
abstract: As the population of many countries ages, disorders of cognition and memory-such as Alzheimer's Disease (AD) and dementia associated with Parkinson's Disease-will become a major societal burden. At present, few effective medical therapies against these conditions are available. Deep brain stimulation (DBS) may be a potential therapeutic option, because it can directly target and modulate the activity of structures implicated in circuits subserving memory function. In this article, we review the scientific literature to address some of the mechanisms by which DBS may impact memory and cognition. We then summarize the results of recent clinical experience with DBS in AD and Parkinsonian dementia.
authors.affiliation: Division of Neurosurgery, Toronto Western Hospital, University of Toronto, Toronto, Canada.
authors.forename: A W
authors.initials: AW
authors.lastname: Laxton
authors.forename: T
authors.initials: T
authors.lastname: Sankar
authors.forename: A M
authors.initials: AM
authors.lastname: Lozano
authors.forename: C
authors.initials: C
authors.lastname: Hamani
mesh_terms: D046690:Deep Brain Stimulation / Q000379:methods*; D006801:Humans; D008568:Memory / Q000502:physiology*; D010300:Parkinson Disease / Q000503:physiopathology / Q000628:therapy*; D020531:Subthalamic Nucleus / Q000503:physiopathology