title: Total oxidative stress and antioxidant status in patients with carpal tunnel syndrome.
abstract: OBJECTIVE
  Studies in the carpal tunnel syndrome (CTS) are supported ischemia-induced changes rather than inflammation of the flexor tenosynovium. In this study, total antioxidant status (TAS), total oxidative stress (TOS) and oxidative stress index (OSI) in patients with  CTS has been investigated.
  
  
  METHODS
  Forty-three patients (38 female and 5 male, 81 hands in total) diagnosed as CTS after the physical examination and electrophysiological findings included in study. The mean age of patients was 43.30 ± 10.49 years.
  
  
  RESULTS
  Bilateral CTS in 38 (88%) patients and unilateral CTS in five patients were detected. Dominant hand was involved in all patients. The mean symptoms duration was 30.9 months (range, 5-67 months). TAS in patients with CTS was significantly lower compared with control  (1.01 ± 0.14 versus 1.11 ± 0.20 mmol Trolox equiv./l), (P = 0.008). TOS and OSI in patients with CTS were significant higher compared with control (15.60 ± 7.03 versus 11.86 ± 2.18 µmol H2O2  equiv./l and 1.57 ± 0.72 versus 1.09 ± 0.28), (respectively P = 0.002 and <0.001).
  
  
  CONCLUSIONS
  This study shows that there is a change in the oxidative stress and antioxidant defences in patients with CTS. Increased TOS  and OSI and decreased TAS might be stimulate fibrosis through disturbed signaling pattern in the tenosynovium and median nerve. These processes might play a role in occurrence and progression of CTS.
authors.affiliation: Physical Medicine and Rehabilitation Department, Harran University, Turkey.
authors.forename: Ahmet
authors.initials: A
authors.lastname: Demirkol
authors.forename: Murat
authors.initials: M
authors.lastname: Uludag
authors.forename: Neslihan
authors.initials: N
authors.lastname: Soran
authors.forename: Nurten
authors.initials: N
authors.lastname: Aksoy
authors.forename: Kerem
authors.initials: K
authors.lastname: Gun
authors.forename: Serap
authors.initials: S
authors.lastname: Incebıyık
authors.forename: Ismahan
authors.initials: I
authors.lastname: Gurgen
authors.forename: Mehmet
authors.initials: M
authors.lastname: Vural
authors.forename: Yasşar
authors.initials: Y
authors.lastname: Altun
authors.forename: Fatma Nur
authors.initials: FN
authors.lastname: Kesiktas
mesh_terms: D000328:Adult; D000975:Antioxidants / Q000032:analysis*; D002349:Carpal Tunnel Syndrome / Q000097:blood* / Q000209:etiology / Q000503:physiopathology; D003238:Connective Tissue / Q000098:blood supply; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009431:Neural Conduction; D018384:Oxidative Stress; D010808:Physical Examination; D011826:Radial Nerve / Q000503:physiopathology; D015427:Reperfusion Injury / Q000150:complications / Q000378:metabolism; D012720:Severity of Illness Index; D014953:Wrist / Q000098:blood supply
chemical_list: D000975:Antioxidants