title: Synthesis and glycosidase inhibitory activity of novel (2-phenyl-4H-benzopyrimedo[2,1-b]-thiazol-4-yliden)acetonitrile derivatives.
abstract: A series of (2-phenyl-4H-benzopyrimodo[2,1-b][1,3]thiazol-4-yliden-4-yliden)acetonitrile derivatives have been prepared by ring transformation reaction of 4-(methylthio)-2-oxo-6-aryl-2H-pyrane-3-carbonitriles. The yield of ring transformation product is moderate to good. Furthermore the glycosidase inhibitory activities were tested by using α-amylase and α-glucosidase pancreatic, intestinal and liver enzymes, responsible for hyperglycemia in type II diabetes. The results revealed that all compounds exhibit significant glycosidase inhibitory activity.
authors.affiliation: Department of Organic Chemistry, North Maharashtra University, Jalgaon 425 001, India.
authors.forename: Vijay S
authors.initials: VS
authors.lastname: Patil
authors.forename: Kamalakar P
authors.initials: KP
authors.lastname: Nandre
authors.forename: Sougata
authors.initials: S
authors.lastname: Ghosh
authors.forename: Vaidya Jayathirtha
authors.initials: VJ
authors.lastname: Rao
authors.forename: Balu A
authors.initials: BA
authors.lastname: Chopade
authors.forename: Sheshanath V
authors.initials: SV
authors.lastname: Bhosale
authors.forename: Sidhanath V
authors.initials: SV
authors.lastname: Bhosale
mesh_terms: D000097:Acetonitriles / Q000138:chemical synthesis / Q000737:chemistry* / Q000378:metabolism / Q000494:pharmacology*; D000681:Amylases / Q000037:antagonists & inhibitors / Q000378:metabolism; D000818:Animals; D004789:Enzyme Activation / Q000187:drug effects; D004791:Enzyme Inhibitors / Q000138:chemical synthesis* / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology*; D065089:Glycoside Hydrolase Inhibitors; D007004:Hypoglycemic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000378:metabolism; D007422:Intestines / Q000201:enzymology; D008099:Liver / Q000201:enzymology; D051379:Mice; D010179:Pancreas / Q000201:enzymology; D011485:Protein Binding; D013552:Swine; D000520:alpha-Glucosidases / Q000378:metabolism
chemical_list: D000097:Acetonitriles; D004791:Enzyme Inhibitors; D065089:Glycoside Hydrolase Inhibitors; D007004:Hypoglycemic Agents; D000681:Amylases; D000520:alpha-Glucosidases; C032159:acetonitrile