title: IB-MECA, an adenosine A(3) receptor agonist, does not influence survival of lethally γ-irradiated mice.
abstract: In our previous studies, IB-MECA, an adenosine A(3) receptor agonist, was found to stimulate proliferation of hematopoietic progenitor and precursor cells in mice. This property of IB-MECA was considered to be responsible for its ability to support regeneration of suppressed hematopoiesis after irradiation with sublethal doses of γ-rays when the drug was given in a post-irradiation treatment regimen. This study was aimed at assessing the ability of IB-MECA to influence a 30-day survival of lethally irradiated mice. In a series of experiments, IB-MECA was administered following various lethal radiation doses in various numbers of drug doses and various administration routes. Though in some of these experiments a moderate increase in 30-day survival was observed in IB-MECA-treated mice, the differences in comparison with the controls were not significantly different. It can be inferred from these results and those of previous studies assessing the effects of IB-MECA after sublethal radiation doses that IB-MECA can probably influence only a substantially preserved hematopoiesis like that remaining after sublethal irradiation. Future studies should be aimed at evaluation of the abilities of IB-MECA to influence post-irradiation survival when administered as a part of combined treatment regimens.
authors.affiliation: Laboratory of Experimental Hematology, Institute of Biophysics, Academy of Sciences of the Czech Republic, Brno, Czech Republic. hofer@ibp.cz
authors.forename: M
authors.initials: M
authors.lastname: Hofer
authors.forename: M
authors.initials: M
authors.lastname: Pospíšil
authors.forename: L
authors.initials: L
authors.lastname: Dušek
authors.forename: Z
authors.initials: Z
authors.lastname: Hoferová
authors.forename: D
authors.initials: D
authors.lastname: Komůrková
mesh_terms: D000241:Adenosine / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000494:pharmacology; D058909:Adenosine A3 Receptor Agonists / Q000008:administration & dosage / Q000494:pharmacology*; D000818:Animals; D005720:Gamma Rays; D006410:Hematopoiesis / Q000187:drug effects / Q000528:radiation effects; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D011833:Radiation Injuries, Experimental / Q000378:metabolism / Q000401:mortality*; D043684:Receptor, Adenosine A3 / Q000378:metabolism*
chemical_list: D058909:Adenosine A3 Receptor Agonists; D043684:Receptor, Adenosine A3; C084956:N(6)-(3-iodobenzyl)-5'-N-methylcarboxamidoadenosine; D000241:Adenosine