title: A new hydroxytyrosol metabolite identified in human plasma: hydroxytyrosol acetate sulphate.
abstract: We report progress in the study of olive oil phenolic metabolites in humans and identify a new hydroxytyrosol metabolite called hydroxytyrosol acetate sulphate, which was determined using tandem MS, after ingestion of 30 ml of olive oil with a high phenolic content (500 mg/kg oil), reaching a maximum concentration of 1.63 μM. In order to understand and explain the generation of this metabolite, two different pathways are proposed.
authors.affiliation: Food Technology Department, XaRTA-TPV, Escola Tecnica Superior d'Enginyeria Agrària, Universitat de Lleida, University of Lleida, Alcalde Rovira Roure 191, 25198 Lleida, Spain.
authors.forename: Laura
authors.initials: L
authors.lastname: Rubió
authors.forename: Alba
authors.initials: A
authors.lastname: Macià
authors.forename: Rosa M
authors.initials: RM
authors.lastname: Valls
authors.forename: Anna
authors.initials: A
authors.lastname: Pedret
authors.forename: Maria-Paz
authors.initials: MP
authors.lastname: Romero
authors.forename: Rosa
authors.initials: R
authors.lastname: Solà
authors.forename: Maria-José
authors.initials: MJ
authors.lastname: Motilva
mesh_terms: D002851:Chromatography, High Pressure Liquid; D006801:Humans; D013058:Mass Spectrometry; D053858:Metabolic Networks and Pathways; D015394:Molecular Structure; D000069463:Olive Oil; D010636:Phenols / Q000032:analysis / Q000378:metabolism; D010626:Phenylethyl Alcohol / Q000031:analogs & derivatives* / Q000097:blood / Q000737:chemistry / Q000378:metabolism; D010938:Plant Oils / Q000032:analysis / Q000378:metabolism*
chemical_list: D000069463:Olive Oil; D010636:Phenols; D010938:Plant Oils; C005975:3,4-dihydroxyphenylethanol; D010626:Phenylethyl Alcohol