title: [Research advance of hematopoietic microenvironment for myelodysplastic syndromes].
abstract: Myelodysplastic syndrome (MDS) is a group of heterogeneous clonal diseases characterized by ineffective hematopoiesis, peripheral blood cytopenias and high risk of transformation to acute myeloid leukemia.Recently more and more investigations indicate that the abnormality of bone marrow microenvironment is one of important reasons related to MDS. In this article the abnormality of stroma cells, cytokines and signaling pathways in hematopoietic micro-environment of MDS is reviewed.
authors.affiliation: Department of Hematology, The 6th Hospital Affilated to Shanghai Jiaotong University, Shanghai, China.
authors.forename: Cheng-Ming
authors.initials: CM
authors.lastname: Fei
authors.forename: Chun-Kang
authors.initials: CK
authors.lastname: Chang
mesh_terms: D001853:Bone Marrow; D060833:Cellular Microenvironment; D016207:Cytokines / Q000378:metabolism; D006801:Humans; D009190:Myelodysplastic Syndromes; D015398:Signal Transduction; D017154:Stromal Cells / Q000378:metabolism
chemical_list: D016207:Cytokines