title: The dynamic optical breast imaging in the preoperative workflow of women with suspicious or malignant breast lesions: development of a new comprehensive score.
abstract: Purpose. To determine the diagnostic accuracy of DOBIComfortScan in patients with Breast Imaging Reporting suspect breast lesions (BI-RADS) 4-5 breast lesions. Materials and Methods. One-hundred and thirteen patients underwent DOBIComfortScan examination before surgery. Twelve parameters were taken into consideration to define DOBI findings. Results. Twenty-seven radical mastectomies, 47 quadrantectomies and 39 wide excisions, were performed. Overall, 65 invasive cancer, 9 in situ carcinoma and 39 nonmalignant lesions, were observed. Ten out of 12 considered parameters resulted significantly in association with histology at discriminant analysis. A summation score of 30.5 resulted to be the best cut off at ROC analysis, giving a sensitivity and specificity of 80% and 87%, respectively, and a positive predictive value of 92.2%. Finally the following DOBI-BI-RADS model was developed: malignant B5 ≥ 38 score); possibly malignant (B4 = 25 - 37 score); benign but the possibility of malignancy cannot be excluded (B3 = 20 - 24 score); benign (B2 < 20 score). Conclusion. definition of other parameters permits to improve the accuracy of this procedure. Further studies are warranted to define the potential role of DOBIComfortScan in breast cancer imaging.
authors.affiliation: Department of Breast Disease, National Cancer Institute "G. Pascale" Foundation, Via Mariano Semmola, 80136 Naples, Italy.
authors.forename: Massimiliano
authors.initials: M
authors.lastname: D'Aiuto
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Frasci
authors.forename: Maria Luisa
authors.initials: ML
authors.lastname: Barretta
authors.forename: Adolfo
authors.initials: A
authors.lastname: Gallipoli
authors.forename: Giovanni Maria
authors.initials: GM
authors.lastname: Ciuffo
authors.forename: Flavia
authors.initials: F
authors.lastname: Musco
authors.forename: Sergio
authors.initials: S
authors.lastname: Orefice
authors.forename: Viviana
authors.initials: V
authors.lastname: Frattini
authors.forename: Ilves
authors.initials: I
authors.lastname: Guidi
authors.forename: Claudio
authors.initials: C
authors.lastname: Siani
authors.forename: Emanuela
authors.initials: E
authors.lastname: Esposito
authors.forename: Anna
authors.initials: A
authors.lastname: Crispo
authors.forename: Maurizio
authors.initials: M
authors.lastname: Montella
authors.forename: Andrea
authors.initials: A
authors.lastname: Chirico
authors.forename: Giuseppe
authors.initials: G
authors.lastname: D'Aiuto
authors.forename: Aldo
authors.initials: A
authors.lastname: Vecchione