title: Synovex Plus implants coated with a polymeric, porous film improve performance of beef steers and heifers fed in confinement for up to 200 days.
abstract: Synovex Plus (SP) is a product that delivers 28 mg of estradiol benzoate (EB) and 200 mg of trenbolone acetate (TBA). We studied the impact of a polymeric, porous coating on SP implants (CSP) to prolong release of EB and TBA, and stimulate feedlot performance of feedlot cattle for an extended period. In an explant study, 30 steers were implanted with SP in one ear and CSP in the contralateral ear. Cattle (n = 6/d) were necropsied 40, 81, 120, 160, and 200 d after treatment, and remaining EB and TBA were quantified. Linear regression of EB and TBA remaining as a function of time for each treatment were computed. Rates of EB and TBA depletion from SP were -0.1980 (r(2) = 0.9994) and -1.7073 mg/d (r(2) = 0.9644), respectively, and for CSP rates of EB and TBA depletion were -0.1049 (r(2) = 0.9123) and -0.9466 mg/d (r(2) = 0.9297), respectively. The effect of treatment on depletion rates of each analyte were significant (P < 0.05). Data also showed EB and TBA were delivered from CSP at least 200 d but were delivered from SP about 120 d. Multisite trials with beef-type steers (4 sites) and heifers (4 sites) evaluated feedlot performance and carcass characteristics in response to a CSP implant or when sham implanted (SC). A randomized complete block design with 9 blocks and 2 treatments was used per site within animal gender. Across sites, steers (n = 342, BW = 297 kg) were fed finishing rations for 190 to 202 d (mean 198 d) and heifers (n = 342, BW = 289 kg) were fed finishing rations for 191 to 201 d (mean 198 d). Cattle were harvested and carcasses evaluated. Data were pooled across sites within gender for statistical analysis. Steers and heifers treated with CSP yielded greater (P ≤ 0.003) ADG, DMI, and G:F than SC steers and heifers. Mean BW differences between CSP and SC continued to increase throughout the study, indicating CSP stimulated growth of steers and heifers for 198 d. Mean carcass weights of CSP steers (P = 0.005) and heifers (P = 0.004) were greater than those of SP steers and heifers by 26.2 and 20.6 kg, respectively. The LM area was larger (P < 0.001) in CSP steers and heifers than SC cattle. Marbling decreased with CSP treatment (P ≤ 0.031), which caused reductions (P ≤ 0.006) in proportions of carcasses grading Prime or Choice. Evidence from these studies showed that a single administration of CSP increased feedlot cattle performance for at least 198 d, compared with SC, and may reduce the need to reimplant cattle.
authors.affiliation: Pfizer Animal Health, 5 Giralda Farms, Madison, NJ 07940, USA. ralph.cleale@pfizer.com
authors.forename: R M
authors.initials: RM
authors.lastname: Cleale
authors.forename: D T
authors.initials: DT
authors.lastname: Bechtol
authors.forename: J S
authors.initials: JS
authors.lastname: Drouillard
authors.forename: J D
authors.initials: JD
authors.lastname: Edmonds
authors.forename: M
authors.initials: M
authors.lastname: Edmonds
authors.forename: B D
authors.initials: BD
authors.lastname: Hunsaker
authors.forename: L A
authors.initials: LA
authors.lastname: Kraft
authors.forename: T E
authors.initials: TE
authors.lastname: Lawrence
authors.forename: S
authors.initials: S
authors.lastname: Brewbaker
authors.forename: A R
authors.initials: AR
authors.lastname: Waite
mesh_terms: D000277:Adjuvants, Pharmaceutic / Q000008:administration & dosage*; D045930:Anabolic Agents / Q000008:administration & dosage*; D000822:Animal Husbandry; D000818:Animals; D002417:Cattle / Q000254:growth & development* / Q000378:metabolism*; D004338:Drug Combinations; D004343:Drug Implants / Q000008:administration & dosage; D004958:Estradiol / Q000008:administration & dosage / Q000031:analogs & derivatives*; D005260:Female; D008297:Male; D013997:Time Factors; D014204:Trenbolone Acetate / Q000008:administration & dosage*
chemical_list: D000277:Adjuvants, Pharmaceutic; D045930:Anabolic Agents; D004338:Drug Combinations; D004343:Drug Implants; C074283:estradiol 3-benzoate; D004958:Estradiol; D014204:Trenbolone Acetate