title: Systems mapping of HIV-1 infection.
abstract: Mathematical models of viral dynamics in vivo provide incredible insights into the mechanisms for the nonlinear interaction between virus and host cell populations, the dynamics of viral drug resistance, and the way to eliminate virus infection from individual patients by drug treatment. The integration of these mathematical models with high-throughput genetic and genomic data within a statistical framework will raise a hope for effective treatment of infections with HIV virus through developing potent antiviral drugs based on individual patients' genetic makeup. In this opinion article, we will show a conceptual model for mapping and dictating a comprehensive picture of genetic control mechanisms for viral dynamics through incorporating a group of differential equations that quantify the emergent properties of a system.
authors.affiliation: Center for Computational Biology, Beijing Forestry University, Beijing 100081, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Hou
authors.forename: Yihan
authors.initials: Y
authors.lastname: Sui
authors.forename: Zhong
authors.initials: Z
authors.lastname: Wang
authors.forename: Yaqun
authors.initials: Y
authors.lastname: Wang
authors.forename: Ningtao
authors.initials: N
authors.lastname: Wang
authors.forename: Jingyuan
authors.initials: J
authors.lastname: Liu
authors.forename: Yao
authors.initials: Y
authors.lastname: Li
authors.forename: Maureen
authors.initials: M
authors.lastname: Goodenow
authors.forename: Li
authors.initials: L
authors.lastname: Yin
authors.forename: Zuoheng
authors.initials: Z
authors.lastname: Wang
authors.forename: Rongling
authors.initials: R
authors.lastname: Wu
mesh_terms: D019380:Anti-HIV Agents / Q000494:pharmacology / Q000627:therapeutic use; D002874:Chromosome Mapping; D024882:Drug Resistance, Viral; D005838:Genotype; D015658:HIV Infections / Q000188:drug therapy / Q000821:virology*; D015497:HIV-1 / Q000187:drug effects / Q000235:genetics*; D006801:Humans; D008962:Models, Theoretical
chemical_list: D019380:Anti-HIV Agents