title: Inhibitors of N-glycosylation as a potential tool for analysis of the mechanism of action and cellular localisation of glycoprotein P.
abstract: Multidrug resistance has for many years attracted attention of numerous investigators. Attempts have also been made to increase efficiency of anti-neoplastic therapy. For this reason, most of efforts have been devoted to analysing proteins engaged in the mechanism of multidrug resistance such as the N-glycosylated membrane protein glycoprotein P. Interestingly, glycosylation probably plays a significant role in the intracellular location and activity of modified proteins. Inhibitors of glycosylation have been demonstrated to alter the activity of glycoprotein P in various ways, depending on the cell line examined. These inhibitors markedly reduce multidrug resistance of cancer cells, thus promoting success of anti-neoplastic therapy. Here, we review the basic knowledge on N-glycosylation inhibitors, their effect on glycoprotein P and their therapeutic potential.
authors.affiliation: Department of Histology and Embryology, Poznan University of Medical Sciences, Poznań, Poland.
authors.forename: Karolina
authors.initials: K
authors.lastname: Wojtowicz
authors.forename: Witold
authors.initials: W
authors.lastname: Szaflarski
authors.forename: Radosław
authors.initials: R
authors.lastname: Januchowski
authors.forename: Piotr
authors.initials: P
authors.lastname: Zawierucha
authors.forename: Michał
authors.initials: M
authors.lastname: Nowicki
authors.forename: Maciej
authors.initials: M
authors.lastname: Zabel
mesh_terms: D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1 / Q000235:genetics / Q000378:metabolism; D002467:Cell Nucleus / Q000201:enzymology / Q000378:metabolism / Q000648:ultrastructure; D018432:Drug Resistance, Multiple / Q000235:genetics; D019008:Drug Resistance, Neoplasm / Q000235:genetics*; D004791:Enzyme Inhibitors / Q000737:chemistry / Q000627:therapeutic use; D006031:Glycosylation; D006801:Humans; D008565:Membrane Proteins / Q000037:antagonists & inhibitors / Q000235:genetics / Q000378:metabolism; D008566:Membranes / Q000201:enzymology / Q000648:ultrastructure; D009369:Neoplasms / Q000188:drug therapy / Q000201:enzymology
chemical_list: D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1; D004791:Enzyme Inhibitors; D008565:Membrane Proteins