title: Effect of triterpene derivatives on the total hepatocyte count in the liver of rats with toxic hepatitis.
abstract: We studied hepatoprotective activity of betulonic acid and its alaninamide on the model of combined CCl(4)- and ethanol-induced toxic liver damage in rats. The test substances, especially betulonic acid alaninamide, considerably reduced the elevated biochemical parameters in animals with toxic liver damage. Betulonic acid alaninamide also stimulated reparative processes in the liver (activated hepatocyte proliferation). Heptral (reference drug) produced no appreciable effects on the reparative processes. Our findings suggest that betulin derivatives exhibit pronounced protective properties.
authors.affiliation: N. N. Vorozhtsov Institute of Organic Chemistry, Siberian Division of the Russian Academy of Sciences, Russia.
authors.forename: D E
authors.initials: DE
authors.lastname: Semenov
authors.forename: N A
authors.initials: NA
authors.lastname: Zhukova
authors.forename: E P
authors.initials: EP
authors.lastname: Bessergeneva
authors.forename: I V
authors.initials: IV
authors.lastname: Sorokina
authors.forename: D S
authors.initials: DS
authors.lastname: Baev
authors.forename: B M
authors.initials: BM
authors.lastname: Glukhov
authors.forename: G I
authors.initials: GI
authors.lastname: Nepomnyaschikh
authors.forename: T G
authors.initials: TG
authors.lastname: Tolstikova
mesh_terms: D000410:Alanine Transaminase / Q000378:metabolism; D000469:Alkaline Phosphatase / Q000378:metabolism; D000577:Amides / Q000737:chemistry; D000818:Animals; D001219:Aspartate Aminotransferases / Q000378:metabolism; D002251:Carbon Tetrachloride / Q000633:toxicity*; D002452:Cell Count; D049109:Cell Proliferation / Q000187:drug effects; D056486:Chemical and Drug Induced Liver Injury / Q000188:drug therapy* / Q000201:enzymology / Q000473:pathology; D000431:Ethanol / Q000633:toxicity*; D005260:Female; D022781:Hepatocytes / Q000187:drug effects* / Q000201:enzymology / Q000473:pathology; D007770:L-Lactate Dehydrogenase / Q000378:metabolism; D008099:Liver / Q000187:drug effects* / Q000201:enzymology / Q000473:pathology; D009828:Oleanolic Acid / Q000031:analogs & derivatives* / Q000494:pharmacology / Q000627:therapeutic use; D051381:Rats; D000094062:Betulinic Acid
chemical_list: D000410:Alanine Transaminase; D000469:Alkaline Phosphatase; D000577:Amides; D001219:Aspartate Aminotransferases; D002251:Carbon Tetrachloride; D000431:Ethanol; D007770:L-Lactate Dehydrogenase; D009828:Oleanolic Acid; C118308:betulonic acid; D000094062:Betulinic Acid