title: Invasive cribriform carcinoma arising in malignant phyllodes tumor of breast: a case report.
abstract: Phyllodes tumor is an uncommon fibroepithelial neoplasm of the breast. And it is characterized by expanded stroma with increased cellularity and elongated epithelium-lined clefts. Mammary carcinomas within phyllodes tumors have been rarely reported. To date, however, no reports have described the invasive cribriform carcinoma arising in malignant phyllodes tumor. Here, we report a 62-year-old woman who presented with a large breast mass. Microscopically, the mass was a typical malignant phyllodes tumor showing well developed leaf-like architecture and stromal overgrowth with high cellularity and nuclear pleomorphism. In a portion of the tumor, however, the epithelial component showed a cribriform pattern of proliferation in the absence of myoepithelial cells, suggestive of the invasive cribriform carcinoma. To our knowledge, this is rare and it is difficult to make a differential diagnosis of it. Here, we report our case with a review of literatures.
authors.affiliation: Department of Pathology, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Korea.
authors.forename: Yoomi
authors.initials: Y
authors.lastname: Choi
authors.forename: Kyoung Yul
authors.initials: KY
authors.lastname: Lee
authors.forename: Min Hye
authors.initials: MH
authors.lastname: Jang
authors.forename: Hyesil
authors.initials: H
authors.lastname: Seol
authors.forename: Sung-Won
authors.initials: SW
authors.lastname: Kim
authors.forename: So Yeon
authors.initials: SY
authors.lastname: Park
keywords: Breast; Cribriform; Invasive carcinoma; Phyllodes tumor