title: Multiple axillary-infraclavicular lymph node metastasis from malignant rhabdoid tumor of unknown primary site.
abstract: Malignant rhabdoid tumors (MRT) mostly originate from the kidney and central nervous system. However, they may also originate from retroperitoneal and paravertebral regions, mediastinum, liver, chest wall, extremity, and neck, as well as from the soft tissues. The most important method in the differential diagnosis is the analysis of cytogenetic alterations in the INI1 gene. A six-month-old girl presented with multiple conglomerated lymphadenopathies located in the anterior axillary line. MRT diagnosis was confirmed by loss of INI1 expression in the tumor tissue. This is the first case in the literature with unknown primary focus diagnosed from lymph node metastasis.
authors.affiliation: Divisions of Pediatric Oncology, Ankara Children's Hematology Oncology Training and Research Hospital, Ankara, Turkey.
authors.forename: Haci Ahmet
authors.initials: HA
authors.lastname: Demir
authors.forename: Ayper
authors.initials: A
authors.lastname: Kaçar
authors.forename: Suna
authors.initials: S
authors.lastname: Emir
authors.forename: Birsen Songül
authors.initials: BS
authors.lastname: Cihan
authors.forename: Bahattin
authors.initials: B
authors.lastname: Tunç
mesh_terms: D001365:Axilla; D003937:Diagnosis, Differential; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D007223:Infant; D008207:Lymphatic Metastasis; D009382:Neoplasms, Unknown Primary / Q000473:pathology*; D011859:Radiography; D018335:Rhabdoid Tumor / Q000000981:diagnostic imaging / Q000473:pathology*; D014463:Ultrasonography