title: [Primary bone lymphoma with multicentric involvement].
abstract: Primary bone lymphoma is a rare disease, which usually has a different presentation and evolution than lymphomas of other locations. We are presenting a case of primary bone lymphoma of rapid growth, in cranial and sternal locations. In its evolution, once the excision of the primary lesion of the skull was performed, the patient presented new lesions of rapid growth at the skull and femur level, and progression of pre-sternal lesion. With large B-cell diffuse non-Hodgkin lymphoma pathology, the patient initiated R-CHOPP (cyclophosphamide, doxorubicin, vincristine, prednisone and rituximab) with rapid reduction of all lesions without evidence of progression after the six cycles.
authors.affiliation: Servicio de Clínica Médica, Hospital Ramos Mejía, Buenos Aires, Argentina. marcelograziadio@hotmail.com
authors.forename: Marcelo
authors.initials: M
authors.lastname: Graziadio
authors.forename: Natalia
authors.initials: N
authors.lastname: Medina
authors.forename: Marcelo
authors.initials: M
authors.lastname: Amato
authors.forename: María Del Carmen
authors.initials: Mdel C
authors.lastname: Ardaiz
authors.forename: Santiago
authors.initials: S
authors.lastname: Ilutovich
authors.forename: Marcelo
authors.initials: M
authors.lastname: Torino
mesh_terms: D058846:Antibodies, Monoclonal, Murine-Derived / Q000627:therapeutic use; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D001859:Bone Neoplasms / Q000188:drug therapy / Q000473:pathology*; D003520:Cyclophosphamide / Q000627:therapeutic use; D004317:Doxorubicin / Q000627:therapeutic use; D005260:Female; D005266:Femoral Neoplasms / Q000188:drug therapy / Q000473:pathology; D006801:Humans; D016403:Lymphoma, Large B-Cell, Diffuse / Q000188:drug therapy / Q000473:pathology*; D008875:Middle Aged; D009378:Neoplasms, Multiple Primary / Q000188:drug therapy / Q000473:pathology*; D011241:Prednisone / Q000627:therapeutic use; D035583:Rare Diseases / Q000188:drug therapy / Q000473:pathology; D000069283:Rituximab; D012888:Skull Neoplasms / Q000188:drug therapy / Q000473:pathology*; D013249:Sternum / Q000473:pathology*; D014750:Vincristine / Q000627:therapeutic use
chemical_list: D058846:Antibodies, Monoclonal, Murine-Derived; C571759:R-CHOP protocol; D000069283:Rituximab; D014750:Vincristine; D004317:Doxorubicin; D003520:Cyclophosphamide; D011241:Prednisone