title: Agomelatine augmentation of escitalopram therapy in treatment-resistant obsessive-compulsive disorder: a case report.
abstract: Obsessive-compulsive disorder (OCD) is a chronic condition characterized by obsessions or compulsions that cause distress or interfere with functioning. Selective serotonin reuptake inhibitors are the first-line strategy in the treatment of OCD, but approximately 40% to 60% of patients with OCD fail to respond to them. Several augmentation strategies have been proposed, including the use of atypical antipsychotics and antidepressant combinations. In the present paper we describe the case of a young female patient suffering from severe treatment-resistant OCD who remitted as a result of agomelatine augmentation of escitalopram therapy.
authors.affiliation: NHS, Department of Mental Health, Psychiatric Service of Diagnosis and Treatment, Hospital "G. Mazzini", ASL 4, 64100 Teramo, Italy ; Department of Neurosciences and Imaging, Chair of Psychiatry, University "G. D'Annunzio", 66100 Chieti, Italy.
authors.forename: Domenico
authors.initials: D
authors.lastname: De Berardis
authors.forename: Nicola
authors.initials: N
authors.lastname: Serroni
authors.forename: Stefano
authors.initials: S
authors.lastname: Marini
authors.forename: Giovanni
authors.initials: G
authors.lastname: Martinotti
authors.forename: Francesca
authors.initials: F
authors.lastname: Ferri
authors.forename: Gaetano
authors.initials: G
authors.lastname: Callista
authors.forename: Raffaella
authors.initials: R
authors.lastname: La Rovere
authors.forename: Francesco Saverio
authors.initials: FS
authors.lastname: Moschetta
authors.forename: Massimo
authors.initials: M
authors.lastname: Di Giannantonio