title: Tacrine-6-ferulic acid, a novel multifunctional dimer against Alzheimer's disease, prevents oxidative stress-induced neuronal death through activating Nrf2/ARE/HO-1 pathway in HT22 cells.
authors.forename: Wen-Yong
authors.initials: WY
authors.lastname: Huang
authors.forename: Xiao-Juan
authors.initials: XJ
authors.lastname: Chao
authors.forename: Ying
authors.initials: Y
authors.lastname: Ouyang
authors.forename: An-Min
authors.initials: AM
authors.lastname: Liu
authors.forename: Xi-Xin
authors.initials: XX
authors.lastname: He
authors.forename: Mei-Hui
authors.initials: MH
authors.lastname: Chen
authors.forename: Lan-Hua
authors.initials: LH
authors.lastname: Wang
authors.forename: Jun
authors.initials: J
authors.lastname: Liu
authors.forename: Si-Wang
authors.initials: SW
authors.lastname: Yu
authors.forename: Simona
authors.initials: S
authors.lastname: Rapposelli
authors.forename: Rong-Biao
authors.initials: RB
authors.lastname: Pi
mesh_terms: D000544:Alzheimer Disease / Q000378:metabolism / Q000517:prevention & control; D000818:Animals; D016923:Cell Death / Q000187:drug effects / Q000502:physiology; D002461:Cell Line, Transformed; D003373:Coumaric Acids / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D051547:Heme Oxygenase-1 / Q000096:biosynthesis*; D051379:Mice; D051267:NF-E2-Related Factor 2 / Q000096:biosynthesis*; D009474:Neurons / Q000187:drug effects / Q000378:metabolism; D018384:Oxidative Stress / Q000187:drug effects* / Q000502:physiology; D055503:Protein Multimerization / Q000187:drug effects / Q000502:physiology; D050436:Regulatory Elements, Transcriptional / Q000187:drug effects* / Q000502:physiology; D015398:Signal Transduction / Q000187:drug effects / Q000502:physiology; D013619:Tacrine / Q000031:analogs & derivatives* / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use
chemical_list: D003373:Coumaric Acids; D051267:NF-E2-Related Factor 2; C495635:NFE2L2 protein, human; C574537:tacrine-6-ferulic acid; D013619:Tacrine; C496541:HMOX1 protein, human; D051547:Heme Oxygenase-1