title: Review: the physiological and computational approaches for atherosclerosis treatment.
abstract: The cardiovascular disease has long been an issue that causes severe loss in population, especially those conditions associated with arterial malfunction, being attributable to atherosclerosis and subsequent thrombotic formation. This article reviews the physiological mechanisms that underline the transition from plaque formation in atherosclerotic process to platelet aggregation and eventually thrombosis. The physiological and computational approaches, such as percutaneous coronary intervention and stent design modeling, to detect, evaluate and mitigate this malicious progression were also discussed.
authors.affiliation: Division of Pharmaceutical Sciences, School of Pharmacy, University of Missouri, Kansas City, MO 64108, USA.
authors.forename: Wuchen
authors.initials: W
authors.lastname: Wang
authors.forename: Yugyung
authors.initials: Y
authors.lastname: Lee
authors.forename: Chi H
authors.initials: CH
authors.lastname: Lee
mesh_terms: D000818:Animals; D050197:Atherosclerosis / Q000175:diagnosis* / Q000209:etiology / Q000628:therapy*; D019295:Computational Biology / Q000379:methods* / Q000639:trends; D006801:Humans; D058226:Plaque, Atherosclerotic / Q000150:complications / Q000175:diagnosis / Q000628:therapy; D010974:Platelet Aggregation / Q000187:drug effects / Q000502:physiology; D010975:Platelet Aggregation Inhibitors / Q000494:pharmacology / Q000627:therapeutic use; D013927:Thrombosis / Q000175:diagnosis / Q000209:etiology / Q000628:therapy
chemical_list: D010975:Platelet Aggregation Inhibitors
keywords: Atherosclerosis; Cardiovascular damage; Therapeutic prevention; Thrombosis