title: Tipping the scales early: probing the long-term effects of obesity.
abstract: Obesity has reached epidemic proportions in the United States, and obesity-related illnesses have become a leading preventable cause of death. Childhood obesity is also growing in frequency, and the impact of a lifetime spent in the overweight state is only beginning to emerge in the literature. In this issue of the JCI, Bumaschny et al. used a genetic mouse model to investigate the self-perpetuating nature of obesity and shed some light on why it can become increasingly difficult to lose weight over time.
authors.affiliation: Division of Hypothalamic Research, Department of Internal Medicine, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390, USA.
authors.forename: Chen
authors.initials: C
authors.lastname: Liu
authors.forename: Joel K
authors.initials: JK
authors.lastname: Elmquist
mesh_terms: D000273:Adipose Tissue / Q000503:physiopathology*; D050154:Adiposity; D000818:Animals; D004435:Eating; D007031:Hypothalamus / Q000503:physiopathology*; D009765:Obesity / Q000503:physiopathology* / Q000517:prevention & control*