title: Distribution of erythrocyte binding antigen 175 (EBA-175) alleles and ABO blood groups in a hypoendemic area in Senegal.
abstract: BACKGROUND
  The study was conducted to determine for the first time the association between the erythrocyte binding antigen 175 (EBA-175) alleles and ABO blood groups in malaria patients living in Thies, a hypoendemic area in Senegal.
  
  
  METHODS
  In 2007, the EBA-175 alleles and blood group types were determined by nested PCR and the Simonin test respectively in blood samples obtained from uncomplicated Plasmodium falciparum malaria positive patients.
  
  
  CONCLUSIONS
  In total, 129 patients were enrolled in the study. The EBA-175 genotyping showed a prevalence of 67.45% for the F-allele, 27.90% for the C-allele and 4.65% of mixed C+F infection. The distribution of the ABO blood group type showed 59.8% for the O group, 19.7% for the A group, 17.2% for the B group, and 3.3% for the AB group. No correlation was noted between the EBA-175 alleles and either the blood group type or parasitemia.
authors.affiliation: Department of Parasitologie-Mycologie, Universite Cheikh Anta Diop de Dakar, Dakar, Senegal. asbadiane@gmail.com
authors.forename: Aida S
authors.initials: AS
authors.lastname: Badiane
authors.forename: Ousmane
authors.initials: O
authors.lastname: Sarr
authors.forename: Awa Bineta
authors.initials: AB
authors.lastname: Deme
authors.forename: Ambroise Dioum
authors.initials: AD
authors.lastname: Ahouidi
authors.forename: Papa Elhadji Omar
authors.initials: PE
authors.lastname: Gueye
authors.forename: Mouhamadou
authors.initials: M
authors.lastname: Ndiaye
authors.forename: Mame Cheikh
authors.initials: MC
authors.lastname: Seck
authors.forename: Mouhamadou
authors.initials: M
authors.lastname: Diallo
authors.forename: Amy K
authors.initials: AK
authors.lastname: Bei
authors.forename: Manoj T
authors.initials: MT
authors.lastname: Duraisingh
authors.forename: Dyann
authors.initials: D
authors.lastname: Wirth
authors.forename: Daouda
authors.initials: D
authors.lastname: Ndiaye
authors.forename: Omar
authors.initials: O
authors.lastname: Ndir
authors.forename: Souleymane
authors.initials: S
authors.lastname: Mboup
mesh_terms: D000017:ABO Blood-Group System; D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000483:Alleles; D000953:Antigens, Protozoan / Q000235:genetics*; D002648:Child; D002675:Child, Preschool; D005260:Female; D056726:Genetic Association Studies; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D016778:Malaria, Falciparum / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D010963:Plasmodium falciparum / Q000235:genetics*; D016133:Polymerase Chain Reaction; D015800:Protozoan Proteins / Q000235:genetics*; D012675:Senegal; D055815:Young Adult
chemical_list: D000017:ABO Blood-Group System; D000953:Antigens, Protozoan; D015800:Protozoan Proteins; C065668:erythrocyte-binding antigen 175, Plasmodium