title: The effect of bradykinin B2 receptor polymorphisms on the susceptibility and severity of osteoarthritis in a Chinese cohort.
abstract: BACKGROUND
  The B2-bradykinin receptor (BDKRB2) has been reported to associate with onset and development of Osteoarthritis (OA); however, the role of BDKRB2 genetic polymorphisms in OA remains unknown.
  
  
  METHODS
  A total of 245 patients with primary knee OA and 264 healthy volunteer were recruited. BDKRB2 gene polymorphisms, -58T/C and +9/-9 bp polymorphisms, were genotyped.
  
  
  RESULTS
  The genotype distributions and allele frequencies of +9/-9 bp polymorphisms significantly differed between OA and control subjects. Logistic regression analysis showed carriers with -9/-9 genotype had a significantly increased risk for knee OA compared with the +9/+9 genotype (adjusted OR = 2.356, P < 0.001). The OR for -9 allele carriage was significantly higher than +9 allele carriage (adjusted OR = 1.52, P < 0.001). The +9/-9 bp polymorphisms also determined the OA radiographic severity. The presence of -9 bp was associated with severer OA. The -58T/C polymorphisms did not affect OA risk and severity.
  
  
  CONCLUSIONS
  The +9/-9 bp polymorphisms of BDKRB2 gene may be used as a genetic marker for the susceptibility and severity of OA.
authors.affiliation: Department of Orthopedics Surgery, Tangdu Hospital, The Fourth Military Medical University, Xi'an 710038, China.
authors.forename: Shuo
authors.initials: S
authors.lastname: Chen
authors.forename: Yong
authors.initials: Y
authors.lastname: Zhou
authors.forename: Jun
authors.initials: J
authors.lastname: Li
authors.forename: Le-Qun
authors.initials: LQ
authors.lastname: Shan
authors.forename: Qing-Yu
authors.initials: QY
authors.lastname: Fan
mesh_terms: D002681:China / Q000453:epidemiology; D005260:Female; D020022:Genetic Predisposition to Disease / Q000453:epidemiology* / Q000235:genetics*; D006801:Humans; D008297:Male; D008875:Middle Aged; D020370:Osteoarthritis, Knee / Q000453:epidemiology* / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D015995:Prevalence; D043783:Receptor, Bradykinin B1 / Q000235:genetics*; D012307:Risk Factors; D012720:Severity of Illness Index
chemical_list: D043783:Receptor, Bradykinin B1