title: Young and worried: Age and fear of recurrence in breast cancer survivors.
abstract: OBJECTIVE
  Fear of cancer recurrence (FCR) is a frequently cited and unmet need of cancer survivors. While the relation between age and FCR is well documented, the mechanisms that may explain this phenomenon remain to be investigated. This study examined four possible mechanisms of the relation between age and FCR: motherhood, severity of the cancer (defined as cancer stage and chemotherapy), anxiety, and illness intrusiveness.
  
  
  METHODS
  3,239 women with breast cancer (mean time since diagnosis: 6.6 years) completed the Concerns About Recurrence Scale (CARS), the State Trait Anxiety Inventory (STAI), and the Illness Intrusiveness Ratings Scale (IIRS) within a larger web-based study. Women were divided into four groups based on their current age: < 34, 35-49, 50-64, and >65. Multivariate analyses were performed with age category and motherhood as the independent variables and the CARS subscales as the dependent variables, controlling for age of children and relevant covariates. Severity of the cancer, anxiety, and illness intrusiveness were simultaneously tested as mediators of the relation between age and FCR.
  
  
  RESULTS
  Results indicated that age category was related to FCR, F = 10.37, p < .001. Follow-up tests revealed that women under 34 or 35-49 expressed the highest levels of FCR. Mothers, regardless of their ages or the ages of their children, expressed greater FCR. Illness intrusiveness and to a lesser extent anxiety were mediators of the relation between age and FCR, while severity of the cancer was not.
  
  
  CONCLUSIONS
  Younger age was associated with more FCR among breast cancer patients, regardless of motherhood status. Our findings suggest new, potentially valuable ways of managing FCR by helping affected people to reduce anxiety and illness intrusiveness.
authors.affiliation: School of Psychology, University of Ottawa.
authors.forename: Sophie
authors.identifier: 0000-0003-0019-8849
authors.initials: S
authors.lastname: Lebel
authors.affiliation: School of Psychology, University of Ottawa.
authors.forename: Sara
authors.initials: S
authors.lastname: Beattie
authors.affiliation: School of Psychology, University of Ottawa.
authors.forename: Isabelle
authors.initials: I
authors.lastname: Arès
authors.affiliation: School of Psychology, University of Ottawa.
authors.forename: Catherine
authors.initials: C
authors.lastname: Bielajew
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D001007:Anxiety / Q000523:psychology*; D001943:Breast Neoplasms / Q000473:pathology / Q000523:psychology*; D005239:Fear / Q000523:psychology*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008875:Middle Aged; D009035:Mothers / Q000523:psychology / Q000706:statistics & numerical data; D015999:Multivariate Analysis; D012008:Recurrence; D012307:Risk Factors; D012720:Severity of Illness Index; D017741:Survivors / Q000523:psychology* / Q000706:statistics & numerical data