title: [Comparative analysis of the serum level of autoantibodies as a diagnostic tool of myocardial inflammatory diseases].
abstract: OBJECTIVE
  To assess whether the serum levels of autoantibodies (auto-Abs) interacting with myocardial and vascular wall antigens might be used for the differential diagnosis of myocardial inflammatory diseases. Subjects and methods. Seventeen patients with morphologically documented myocarditis were examined. A comparison group comprised 9 patients with acute myocardial infarction (AMI). A control group included 18 apparently healthy individuals and 8 patients with chronic erosive gastritis (CEG). Serum auto-Abs levels were estimated by the ELI test systems standardized for enzyme immunoassay.
  
  
  RESULTS
  The individual profiles that reflect relative changes in the levels of 16 study auto-Abs and characterize the integral autoreactivity of a patient have clear intergroup differences. Using the profiles of auto-Abs could confirm the diagnosis of myocarditis in 94% of cases or assign the patient to a group of apparently healthy individuals. The informative value of the method in patients with AMI and CEG was 81.8 and 87.5%, respectively.
  
  
  CONCLUSIONS
  The proposed method may be used for the noninvasive screening diagnosis of myocardial inflammatory diseases.
authors.forename: O M
authors.initials: OM
authors.lastname: Moiseeva
authors.forename: L B
authors.initials: LB
authors.lastname: Mitrofanova
authors.forename: E V
authors.initials: EV
authors.lastname: Nakatseva
authors.forename: D A
authors.initials: DA
authors.lastname: Zverev
authors.forename: S V
authors.initials: SV
authors.lastname: Skurydin
authors.forename: A B
authors.initials: AB
authors.lastname: Poletaev
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001323:Autoantibodies / Q000097:blood*; D016022:Case-Control Studies; D002908:Chronic Disease; D005260:Female; D005756:Gastritis / Q000175:diagnosis* / Q000276:immunology; D006801:Humans; D007124:Immunoenzyme Techniques; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000175:diagnosis* / Q000276:immunology; D009205:Myocarditis / Q000175:diagnosis* / Q000276:immunology; D055815:Young Adult
chemical_list: D001323:Autoantibodies