title: Nociceptive sensitivity and lymphocytic index of peripheral blood in rats with different behavioral activity in model of inflammatory pain provoked by injection of freund's complete adjuvant and bovine serum albumin.
abstract: Nociceptive thresholds decreased in rats at the early stage of inflammatory reaction induced by subcutaneous injection of BSA and complete Freund's adjuvant. At the later stage of this reaction, there was a trend of restoring nociceptive parameters in behaviorally passive rats in contrast to active animals, which demonstrated further decrease in the nociceptive thresholds. During the late inflammatory period, the lymphocytic index (by Shaganin) changed unidirectionally in the rats with different behavioral parameters. Probably, the changes in nociceptive thresholds were not triggered by the shift in lymphocyte/segmented neutrophil ratio, but resulted from production of yet not established biologically active agents with proalgesic and analgesic nature.
authors.affiliation: PK Anokhin Institute of Normal Physiology, Russian Academy of Medical Sciences, IM Sechenov First Moscow State Medical University, Moscow, Russia. nikenina@mail.ru
authors.forename: E V
authors.initials: EV
authors.lastname: Nikenina
authors.forename: A Yu
authors.initials: AY
authors.lastname: Abramova
authors.forename: A Yu
authors.initials: AY
authors.lastname: Kozlov
mesh_terms: D000818:Animals; D005620:Freund's Adjuvant / Q000008:administration & dosage / Q000633:toxicity*; D007249:Inflammation / Q000139:chemically induced / Q000150:complications*; D008214:Lymphocytes / Q000187:drug effects; D008297:Male; D009043:Motor Activity / Q000502:physiology; D009504:Neutrophils / Q000187:drug effects; D059226:Nociceptive Pain / Q000209:etiology / Q000503:physiopathology*; D017288:Pain Threshold / Q000187:drug effects* / Q000502:physiology; D051381:Rats; D017208:Rats, Wistar; D012710:Serum Albumin, Bovine / Q000008:administration & dosage / Q000633:toxicity*; D014828:Vocalization, Animal / Q000187:drug effects
chemical_list: D012710:Serum Albumin, Bovine; D005620:Freund's Adjuvant