title: [Research advances on correlation of ARID5B gene with childhood acute lymphoblastic leukemia - review].
abstract: Childhood acute lymphoblastic leukemia (C-ALL) is the most common pediatric cancer. Although its etiology remains poorly understood, the hypothesis of ALL correlated with a genetic basis was examined through association studies based on candidate genes. Recently, two independent large-scale genome-wide association studies reported that the five single nucleotide polymorphisms (rs7073837; rs10821936; rs10994982; rs7089424; rs10740055) in the gene AT rich interactive domain 5B (ARID5B) at 10q21.2, were associated with the high incidence risk of C-ALL, especially with hyperdiploid lymphoblastic leukemia. Variations in these single nucleotide polymorphisms influence the risk of specific disease subtypes, and also possess race- and sex-differences in leukemia incidence. Further elucidation of the mechanisms through which ARID5B variants are involved in C-ALL not only has a great diagnostic value, but also a guidance for the clinical therapy, ultimately improving the prognosis of disease. Therefore, the related studies of ARID5B with C-ALL were summarized briefly in this review.
authors.affiliation: Department of Hematology, Nanjing Medical University, Wuxi, Jiangsu Province, China. qxf5828@sina.com
authors.forename: Xi-Feng
authors.initials: XF
authors.lastname: Qian
authors.forename: Guo-Hua
authors.initials: GH
authors.lastname: Yang
authors.forename: Chen-Yu
authors.initials: CY
authors.lastname: Yin
authors.forename: Xiang
authors.initials: X
authors.lastname: Chen
authors.forename: Yun-Feng
authors.initials: YF
authors.lastname: Shen
mesh_terms: D002648:Child; D004268:DNA-Binding Proteins / Q000235:genetics*; D006801:Humans; D020641:Polymorphism, Single Nucleotide; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000235:genetics*; D014157:Transcription Factors / Q000235:genetics*
chemical_list: C503805:ARID5B protein, human; D004268:DNA-Binding Proteins; D014157:Transcription Factors