title: Malaria research challenges in low prevalence settings.
abstract: The prevalence of malaria has reduced significantly in some areas over the past decade. These reductions have made local elimination possible and the research agenda has shifted to this new priority. However, there are critical issues that arise when studying malaria in low transmission settings, particularly identifying asymptomatic infections, accurate detection of individuals with microparasitaemic infections, and achieving a sufficient sample size to have an adequately powered study. These challenges could adversely impact the study of malaria elimination if they remain unanswered.
authors.affiliation: Department of Immunology and Infection, London School of Hygiene & Tropical Medicine, London, UK.
authors.forename: Gillian
authors.initials: G
authors.lastname: Stresman
authors.forename: Tamaki
authors.initials: T
authors.lastname: Kobayashi
authors.forename: Aniset
authors.initials: A
authors.lastname: Kamanga
authors.forename: Philip E
authors.initials: PE
authors.lastname: Thuma
authors.forename: Sungano
authors.initials: S
authors.lastname: Mharakurwa
authors.forename: William J
authors.initials: WJ
authors.lastname: Moss
authors.forename: Clive
authors.initials: C
authors.lastname: Shiff
mesh_terms: D058070:Asymptomatic Diseases / Q000453:epidemiology*; D060740:Disease Eradication / Q000379:methods*; D004812:Epidemiologic Methods; D006801:Humans; D008288:Malaria / Q000175:diagnosis* / Q000453:epidemiology* / Q000517:prevention & control; D018512:Parasitemia / Q000175:diagnosis* / Q000453:epidemiology* / Q000517:prevention & control; D015995:Prevalence