title: Oxidative stress in the closed-eyelid test: management of glaucoma.
abstract: OBJECTIVE
  To evaluate the role of antioxidant drugs in the tonometric increase that follows the closed eyelid test (CET), a predicitive test for glaucoma, after administration of antioxidant substances was observed.
  
  
  METHODS
  30 subjects of 54.57+/=5.62 years, 13 males and 17 females, were examined by measuring the ocular pressure after 1 hour from the CET, both in normal conditions and after the administration of antioxidants such as: vitamin A (50,000 IU/die), vitamin E (600 mg/die), and vitamin C (1000 mg/die). The increases in temperature of the iridocorneal angle and of the iris were also measured in the same conditions with an infrared Thermo-Precision tonometer (Sola Electro-Optics, China) both before and after CET.
  
  
  RESULTS
  The results showed increased pressure after CET and decreased pressure after the administration of each antioxidant substance, although vitamin A was found to be more effective and with statistically significant values compared to vitamins E and C.
  
  
  CONCLUSIONS
  Considering the responses obtained after administration of antioxidant drugs, the ocular hypertension induced after CET could be a response to mixed stress, oxidative and thermic, with degenerative effects on the trabecular meshwork (TM). Besides, in light of these considerations the research results underline that the open angle glaucoma (OAG) should be considered a multifactorial degenerative disease.
authors.affiliation: Department of Cardiovascular, Respiratory, Nephrology and Geriatric Sciences, Sapienza University of Rome, Rome, Italy. marcella.nebbioso@uniroma1.it
authors.forename: N
authors.initials: N
authors.lastname: Pescosolido
authors.forename: R
authors.initials: R
authors.lastname: Malagola
authors.forename: G
authors.initials: G
authors.lastname: Scarsella
authors.forename: F
authors.initials: F
authors.lastname: Lenarduzzi
authors.forename: L
authors.initials: L
authors.lastname: Dapoto
authors.forename: M
authors.initials: M
authors.lastname: Nebbioso
mesh_terms: D000975:Antioxidants / Q000494:pharmacology; D001205:Ascorbic Acid / Q000494:pharmacology; D001831:Body Temperature; D004249:DNA Damage; D005260:Female; D005902:Glaucoma, Open-Angle / Q000175:diagnosis* / Q000209:etiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D018384:Oxidative Stress; D014801:Vitamin A / Q000494:pharmacology; D014810:Vitamin E / Q000494:pharmacology
chemical_list: D000975:Antioxidants; D014801:Vitamin A; D014810:Vitamin E; D001205:Ascorbic Acid