title: Synthesis of monolysyl advanced glycation endproducts and their incorporation into collagen model peptides.
abstract: The synthesis of advanced glycation endproducts (AGEs), CML, CEL, and pyrraline and their incorporation into collagen model peptides is reported. AGEs are modified amino acids that form on proteins such as collagen and are thought to play a significant role in the pathogenesis of many diseases, particularly diabetes. The synthesis and incorporation of these compounds into synthetic peptides is a key step in developing model systems with which to investigate AGE-modified proteins.
authors.affiliation: School of Chemical Sciences, The University of Auckland, 23 Symonds Street, Auckland, New Zealand.
authors.forename: Tom M
authors.initials: TM
authors.lastname: Woods
authors.forename: Meder
authors.initials: M
authors.lastname: Kamalov
authors.forename: Paul W R
authors.initials: PW
authors.lastname: Harris
authors.forename: Garth J S
authors.initials: GJ
authors.lastname: Cooper
authors.forename: Margaret
authors.initials: M
authors.lastname: Brimble
mesh_terms: D000596:Amino Acids / Q000737:chemistry; D003094:Collagen / Q000737:chemistry; D017127:Glycation End Products, Advanced / Q000138:chemical synthesis* / Q000737:chemistry; D006031:Glycosylation; D008958:Models, Molecular; D015394:Molecular Structure; D010455:Peptides / Q000737:chemistry; D011758:Pyrroles / Q000737:chemistry
chemical_list: D000596:Amino Acids; D017127:Glycation End Products, Advanced; D010455:Peptides; D011758:Pyrroles; D003094:Collagen