title: DvD: An R/Cytoscape pipeline for drug repurposing using public repositories of gene expression data.
abstract: CONCLUSIONS
  Drug versus Disease (DvD) provides a pipeline, available through R or Cytoscape, for the comparison of drug and disease gene expression profiles from public microarray repositories. Negatively correlated profiles can be used to generate hypotheses of drug-repurposing, whereas positively correlated profiles may be used to infer side effects of drugs. DvD allows users to compare drug and disease signatures with dynamic access to databases Array Express, Gene Expression Omnibus and data from the Connectivity Map.
  
  
  METHODS
  R package (submitted to Bioconductor) under GPL 3 and Cytoscape plug-in freely available for download at www.ebi.ac.uk/saezrodriguez/DVD/.
authors.affiliation: European Bioinformatics Institute (EMBL-EBI), Wellcome Trust Genome Campus, Cambridge, UK CB10 1SD.
authors.forename: Clare
authors.initials: C
authors.lastname: Pacini
authors.forename: Francesco
authors.initials: F
authors.lastname: Iorio
authors.forename: Emanuel
authors.initials: E
authors.lastname: Gonçalves
authors.forename: Murat
authors.initials: M
authors.lastname: Iskar
authors.forename: Thomas
authors.initials: T
authors.lastname: Klabunde
authors.forename: Peer
authors.initials: P
authors.lastname: Bork
authors.forename: Julio
authors.initials: J
authors.lastname: Saez-Rodriguez
mesh_terms: D058492:Drug Repositioning; D020869:Gene Expression Profiling; D006801:Humans; D020411:Oligonucleotide Array Sequence Analysis; D012984:Software; D059467:Transcriptome / Q000187:drug effects*