title: Arginine-rich peptides: methods of translocation through biological membranes.
abstract: Intracellular delivery using cell-penetrating peptides (CPPs) has received considerable attention as a promising method for introducing exogenous molecules into cells. The mechanisms that enable efficient internalization of CPPs together with cargo molecules are also of interest. In this review, we describe our current views of membrane translocation of CPPs, especially those rich in arginine, as these peptides represent one of the most frequently employed classes of CPPs.
authors.affiliation: Institute for Chemical Research, Kyoto University, Uji, Kyoto 611-0011, Japan. futaki@scl.kyoto-u.ac.jp
authors.forename: Shiroh
authors.initials: S
authors.lastname: Futaki
authors.forename: Hisaaki
authors.initials: H
authors.lastname: Hirose
authors.forename: Ikuhiko
authors.initials: I
authors.lastname: Nakase
mesh_terms: D001120:Arginine / Q000737:chemistry*; D002462:Cell Membrane / Q000378:metabolism*; D057846:Cell-Penetrating Peptides / Q000378:metabolism*; D016503:Drug Delivery Systems; D006801:Humans; D021381:Protein Transport
chemical_list: D057846:Cell-Penetrating Peptides; D001120:Arginine