title: Pancreatitis with pancreatic tail swelling associated with incretin-based therapies detected radiologically in two cases of diabetic patients with end-stage renal disease.
abstract: We herein report two cases of pancreatitis associated with incretin-based therapies in end-stage renal disease (ESRD) patients undergoing dialysis. A 75-year-old woman with a history of liraglutide use and a 68-year-old man with a history of vildagliptin use both presented with nausea. They showed elevated levels of pancreatic enzymes and pancreatic tail swelling on CT. Their symptoms improved after discontinuing the drugs. In the absence of any obvious secondary causes of pancreatitis, we believe that the pancreatitis observed in these cases was associated with the incretin-based therapies. Few reports have been published on the safety and efficacy of incretin-based therapies in ESRD patients, and it remains uncertain whether the changes in the pancreas observed in the present cases are characteristic of ESRD patients.
authors.affiliation: Department of Nephrology, Japanese Red Cross Society Wakayama Medical Center, Japan. hironakata0808@gmail.com
authors.forename: Hirosuke
authors.initials: H
authors.lastname: Nakata
authors.forename: Seita
authors.initials: S
authors.lastname: Sugitani
authors.forename: Shuhei
authors.initials: S
authors.lastname: Yamaji
authors.forename: Satoko
authors.initials: S
authors.lastname: Otsu
authors.forename: Yoshihito
authors.initials: Y
authors.lastname: Higashi
authors.forename: Yumiko
authors.initials: Y
authors.lastname: Ohtomo
authors.forename: Gen
authors.initials: G
authors.lastname: Inoue
mesh_terms: D000218:Adamantane / Q000009:adverse effects / Q000031:analogs & derivatives; D000368:Aged; D003924:Diabetes Mellitus, Type 2 / Q000150:complications; D003928:Diabetic Nephropathies / Q000628:therapy*; D005260:Female; D052216:Glucagon-Like Peptide 1 / Q000009:adverse effects / Q000031:analogs & derivatives; D006801:Humans; D054795:Incretins / Q000009:adverse effects*; D007676:Kidney Failure, Chronic / Q000628:therapy*; D000069450:Liraglutide; D008279:Magnetic Resonance Imaging; D008297:Male; D009570:Nitriles / Q000009:adverse effects; D010195:Pancreatitis / Q000000981:diagnostic imaging / Q000201:enzymology / Q000209:etiology*; D011759:Pyrrolidines / Q000009:adverse effects; D006435:Renal Dialysis; D014057:Tomography, X-Ray Computed; D000077597:Vildagliptin
chemical_list: D054795:Incretins; D009570:Nitriles; D011759:Pyrrolidines; D000069450:Liraglutide; D052216:Glucagon-Like Peptide 1; D000077597:Vildagliptin; D000218:Adamantane