title: High levels of very long-chain saturated fatty acid in erythrocytes correlates with atherogenic lipoprotein profiles in subjects with metabolic syndrome.
abstract: OBJECTIVE
  Very long chain saturated fatty acid (VLCFA) levels in erythrocytes are associated with metabolic syndrome (MS). However, the relationship between levels of the VLCFA ligonoceric acid (C24:0) in erythrocytes and the atherogenic lipoprotein profiles and inflammatory state in MS remain unclear.
  
  
  METHODS
  Based on the International Diabetes Federation (IDF) definition of MS, 195 apparently healthy males were assigned to either an MS group (n=38) or a non-MS group (n=157). Fatty acid composition of erythrocytes was determined by gas liquid chromatography.
  
  
  RESULTS
  Erythrocytes from the MS group had a significantly higher level of C24:0 than cells from the non-MS group (4.06±0.48% versus 3.88±0.34%; p=0.03). C24:0 levels were significantly correlated with several components of MS. The C24:0 levels showed a significant negative correlation with LDL and HDL particle size. Multivariate linear regression analysis showed that C24:0 levels were independently correlated with LDL particle size after adjusting for age and each MS criterion. C24:0 levels were also positively correlated with log-transformed high-sensitivity CRP levels (p=0.04).
  
  
  CONCLUSIONS
  C24:0 levels in erythrocytes are associated with specific atherogenic lipoprotein profiles and inflammation status in subjects with MS.
authors.affiliation: Department of Cardiovascular Medicine, Juntendo University School of Medicine, Tokyo, Japan.
authors.forename: Rie
authors.initials: R
authors.lastname: Matsumori
authors.forename: Tetsuro
authors.initials: T
authors.lastname: Miyazaki
authors.forename: Kazunori
authors.initials: K
authors.lastname: Shimada
authors.forename: Atsumi
authors.initials: A
authors.lastname: Kume
authors.forename: Yohei
authors.initials: Y
authors.lastname: Kitamura
authors.forename: Kyoichi
authors.initials: K
authors.lastname: Oshida
authors.forename: Naotake
authors.initials: N
authors.lastname: Yanagisawa
authors.forename: Takashi
authors.initials: T
authors.lastname: Kiyanagi
authors.forename: Makoto
authors.initials: M
authors.lastname: Hiki
authors.forename: Kosuke
authors.initials: K
authors.lastname: Fukao
authors.forename: Kuniaki
authors.initials: K
authors.lastname: Hirose
authors.forename: Hiromichi
authors.initials: H
authors.lastname: Ohsaka
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Mokuno
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Daida
mesh_terms: D000328:Adult; D050197:Atherosclerosis / Q000453:epidemiology / Q000209:etiology*; D015415:Biomarkers / Q000097:blood; D002097:C-Reactive Protein / Q000032:analysis; D004912:Erythrocytes / Q000378:metabolism*; D005227:Fatty Acids / Q000097:blood*; D005410:Flame Ionization; D006801:Humans; D007564:Japan / Q000453:epidemiology; D008074:Lipoproteins / Q000097:blood*; D008075:Lipoproteins, HDL / Q000097:blood; D008077:Lipoproteins, LDL / Q000097:blood; D008297:Male; D024821:Metabolic Syndrome / Q000097:blood* / Q000276:immunology / Q000378:metabolism / Q000503:physiopathology; D008875:Middle Aged; D008970:Molecular Weight; D010316:Particle Size; D012307:Risk Factors
chemical_list: D015415:Biomarkers; D005227:Fatty Acids; D008074:Lipoproteins; D008075:Lipoproteins, HDL; D008077:Lipoproteins, LDL; D002097:C-Reactive Protein; C010210:lignoceric acid