title: Physical co-morbidity among treatment resistant vs. treatment responsive patients with major depressive disorder.
abstract: Co-morbid physical illness has been suggested to play an important role among the factors contributing to treatment resistance in patients with major depressive disorder. In the current study we compared the rate of physical co-morbidity, defined by ICD-10, among a large multicenter sample of 702 patients with major depressive disorder. A total of 356 of the participants were defined as treatment resistant depression (TRD) patients-having failed two or more adequate antidepressant trials. No significant difference was found between TRD and non-TRD participants in the prevalence of any ICD-10 category. This finding suggests that although physical conditions such as diabetes, thyroid dysfunction, hypertension, ischemic heart disease, and peptic diseases are often accompanied by co-morbid MDD, they do not necessarily have an impact on the course of MDD or the likelihood to respond to treatment. Marginally higher rates of co-morbid breast cancer, migraine and glaucoma were found among TRD participants. Possible explanations for these findings and their possible relation to TRD are discussed.
authors.affiliation: Department of Psychiatry B, Ness-Ziona Mental Health Center, Tel-Aviv University, Ness-Ziona, Israel.
authors.forename: D
authors.initials: D
authors.lastname: Amital
authors.forename: L
authors.initials: L
authors.lastname: Fostick
authors.forename: A
authors.initials: A
authors.lastname: Silberman
authors.forename: R
authors.initials: R
authors.lastname: Calati
authors.forename: C
authors.initials: C
authors.lastname: Spindelegger
authors.forename: A
authors.initials: A
authors.lastname: Serretti
authors.forename: A
authors.initials: A
authors.lastname: Juven-Wetzler
authors.forename: D
authors.initials: D
authors.lastname: Souery
authors.forename: J
authors.initials: J
authors.lastname: Mendlewicz
authors.forename: S
authors.initials: S
authors.lastname: Montgomery
authors.forename: S
authors.initials: S
authors.lastname: Kasper
authors.forename: J
authors.initials: J
authors.lastname: Zohar
mesh_terms: D000328:Adult; D000928:Antidepressive Agents / Q000627:therapeutic use*; D001943:Breast Neoplasms / Q000453:epidemiology; D015897:Comorbidity; D003865:Major Depressive Disorder / Q000188:drug therapy* / Q000453:epidemiology; D039721:Diagnostic and Statistical Manual of Mental Disorders; D004351:Drug Resistance; D005060:Europe / Q000453:epidemiology; D005260:Female; D005901:Glaucoma / Q000453:epidemiology; D006801:Humans; D007557:Israel / Q000453:epidemiology; D008297:Male; D008881:Migraine Disorders / Q000453:epidemiology; D015995:Prevalence; D011569:Psychiatric Status Rating Scales; D012189:Retrospective Studies; D011795:Surveys and Questionnaires
chemical_list: D000928:Antidepressive Agents
keywords: Depression; Physical co-morbidity; Treatment resistance; Treatment response