title: Surgical treatment of gastrinomas: a single-centre experience.
abstract: BACKGROUND
  Gastrinomas are rare neuroendocrine tumours, and responsible for Zollinger-Ellison syndrome (ZES). Surgery is the only treatment that can cure gastrinomas. The success of surgical treatment of gastrinomas in a single centre was evaluated.
  
  
  METHODS
  A retrospective review of all patients who underwent resection for a gastrinoma between 1992 and 2011 at a single institution was performed. Presentation, diagnostics, operative management and outcome were analysed.
  
  
  RESULTS
  Eleven patients with a median age of 46 years were included. All patients had fasting hypergastrinaemia and a primary tumour was localized using imaging studies in all patients. A pylorus-preserving pancreaticoduodenectomy was performed in three patients: two patients underwent duodenectomy and one patient central pancreatectomy. The remaining five patients underwent enucleation. A primary tumour was removed in nine patients: five tumours were situated in the pancreas, three in the duodenum and one patient was considered to have a primary lymph node gastrinoma. The median follow-up was 3 years (range 1-15) after which 7 patients were disease-free and 3 patients had (suspected) metastatic disease. One patient died 13 years after initial surgery.
  
  
  CONCLUSIONS
  The success of surgical treatment of a gastrinoma in this series was 7/11 with a median follow-up of 3 years; comparable to recent published studies.
authors.affiliation: Department of Surgery, Academic Medical Center, Amsterdam, The Netherlands.
authors.forename: Jasper J
authors.initials: JJ
authors.lastname: Atema
authors.forename: Ramzi
authors.initials: R
authors.lastname: Amri
authors.forename: Olivier R C
authors.initials: OR
authors.lastname: Busch
authors.forename: Erik A J
authors.initials: EA
authors.lastname: Rauws
authors.forename: Dirk J
authors.initials: DJ
authors.lastname: Gouma
authors.forename: Els J M
authors.initials: EJ
authors.lastname: Nieveen van Dijkum
mesh_terms: D000328:Adult; D000368:Aged; D018572:Disease-Free Survival; D004379:Duodenal Neoplasms / Q000401:mortality / Q000473:pathology / Q000601:surgery; D005260:Female; D015408:Gastrinoma / Q000401:mortality / Q000556:secondary / Q000601:surgery*; D006801:Humans; D008198:Lymph Nodes / Q000473:pathology / Q000601:surgery; D008297:Male; D008875:Middle Aged; D064847:Multimodal Imaging; D009426:Netherlands; D010180:Pancreatectomy / Q000009:adverse effects / Q000401:mortality; D010190:Pancreatic Neoplasms / Q000401:mortality / Q000473:pathology / Q000601:surgery*; D016577:Pancreaticoduodenectomy / Q000009:adverse effects / Q000401:mortality; D049268:Positron-Emission Tomography; D012189:Retrospective Studies; D016019:Survival Analysis; D062606:Tertiary Care Centers; D013997:Time Factors; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome