title: Hyperpolarized helium-3 magnetic resonance imaging of chronic obstructive pulmonary disease exacerbation.
abstract: A chronic obstructive pulmonary disease (COPD) exsmoker underwent pulmonary function tests and hyperpolarized helium-3 ((3) He) magnetic resonance imaging (MRI) serially over 4 years, twice prior to and twice following an acute exacerbation (AE). About 2.5 years pre-AE, (3) He ventilation defect percent (VDP) was 16%, the apparent diffusion coefficient (ADC) was 0.34 cm(2) /s, and forced expiratory volume in 1 sec (FEV1 ) was 41%pred . Six months pre-AE, VDP and ADC were worse (29% and 0.38 cm(2) /s, respectively) without worsening FEV1 (47%pred ). After hospitalization and AE treatment, VDP was 20%, whereas FEV1 did not improve (45%pred ); 16 months post-AE, both VDP and ADC remained improved and similar to 4 years prior.
authors.affiliation: Imaging Research Laboratories, Robarts Research Institute, London, Canada; Department of Medical Biophysics, University of Western Ontario, London, Canada.
authors.forename: Miranda
authors.initials: M
authors.lastname: Kirby
authors.forename: Nikhil
authors.initials: N
authors.lastname: Kanhere
authors.forename: Roya
authors.initials: R
authors.lastname: Etemad-Rezai
authors.forename: David G
authors.initials: DG
authors.lastname: McCormack
authors.forename: Grace
authors.initials: G
authors.lastname: Parraga
mesh_terms: D000280:Administration, Inhalation; D000368:Aged; D003287:Contrast Media; D018450:Disease Progression; D005260:Female; D006371:Helium / Q000008:administration & dosage; D006801:Humans; D007554:Isotopes / Q000008:administration & dosage; D008137:Longitudinal Studies; D008168:Lung / Q000473:pathology*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D029424:Pulmonary Disease, Chronic Obstructive / Q000175:diagnosis*; D019275:Radiopharmaceuticals / Q000008:administration & dosage; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D012720:Severity of Illness Index
chemical_list: D003287:Contrast Media; D007554:Isotopes; D019275:Radiopharmaceuticals; D006371:Helium