title: Metabolic acidosis in a pediatric patient receiving topiramate.
abstract: Topiramate is an anticonvulsant that is labeled for the management of several seizure types in children >2 years of age. With the exception of cognitive dysfunction, nephrolithiasis, weight loss, and paresthesia, adverse effects in children are similar to other those noted with other anticonvulsants. We describe a 33-month-old child with complex partial seizures and secondary generalization who received topiramate 45 mg orally twice daily (6.2 mg/kg/d) for approximately 4 weeks before admission. He developed asymptomatic metabolic acidosis that was evidenced by a decrease in HCO(3) (-), which was unresponsive to treatment with sodium bicarbonate. The child was weaned off topiramate and the metabolic acidosis resolved 48 hours after its discontinuation.
authors.affiliation: Covenant Medical Center-Children's Hospital, Lubbock, Texas.
authors.forename: Razia
authors.initials: R
authors.lastname: Malik
authors.forename: John
authors.initials: J
authors.lastname: Iacoune
keywords: adverse effects; child; metabolic acidosis; pediatrics; topiramate