title: Chronic low-dose exposure in the Techa River Cohort: risk of mortality from circulatory diseases.
abstract: The aim of the present study was to analyze the mortality from circulatory diseases for about 30,000 members of the Techa River cohort over the period 1950-2003, and to investigate how these rates depend on radiation doses. This population received both external and internal exposures from (90)Sr, (89)Sr, (137)Cs, and other uranium fission products as a result of waterborne releases from the Mayak nuclear facility in the Southern Urals region of the Russian Federation. The analysis included individualized estimates of the total (external plus internal) absorbed dose in muscle calculated based on the Techa River Dosimetry System 2009. The cohort-average dose to muscle tissue was 35 mGy, and the maximum dose was 510 mGy. Between 1950 and 2003, 7,595 deaths from circulatory diseases were registered among cohort members with 901,563 person years at risk. Mortality rates in the cohort were analyzed using a simple parametric excess relative risk (ERR) model. For all circulatory diseases, the estimated excess relative risk per 100 mGy with a 15-year lag period was 3.6 % with a 95 % confidence interval of 0.2-7.5 %, and for ischemic heart disease it was 5.6 % with a 95 % confidence interval of 0.1-11.9 %. A linear ERR model provided the best fit. Analyses with a lag period shorter than 15 years from the beginning of exposure did not reveal any significant risk of mortality from either all circulatory diseases or ischemic heart disease. There was no evidence of an increased mortality risk from cerebrovascular disease (p > 0.5). These results should be regarded as preliminary, since they will be updated after adjustment for smoking and alcohol consumption.
authors.affiliation: Urals Research Center for Radiation Medicine, 68-a, Vorovsky St., Chelyabinsk 454076, Russia. ludmila@urcrm.ru
authors.forename: Lyudmila Yurievna
authors.initials: LY
authors.lastname: Krestinina
authors.forename: Svetlana
authors.initials: S
authors.lastname: Epifanova
authors.forename: Stanislav
authors.initials: S
authors.lastname: Silkin
authors.forename: Lyudmila
authors.initials: L
authors.lastname: Mikryukova
authors.forename: Marina
authors.initials: M
authors.lastname: Degteva
authors.forename: Natalia
authors.initials: N
authors.lastname: Shagina
authors.forename: Alexander
authors.initials: A
authors.lastname: Akleyev
mesh_terms: D000328:Adult; D000368:Aged; D002318:Cardiovascular Diseases / Q000209:etiology / Q000401:mortality*; D002588:Cesium Radioisotopes / Q000009:adverse effects; D015331:Cohort Studies; D004032:Diet; D004781:Environmental Exposure / Q000009:adverse effects*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009132:Muscles / Q000378:metabolism; D011829:Radiation Dosage; D011839:Radiation, Ionizing; D012306:Risk; D045483:Rivers; D012426:Russia / Q000453:epidemiology; D013326:Strontium Radioisotopes / Q000009:adverse effects; D055815:Young Adult
chemical_list: D002588:Cesium Radioisotopes; D013326:Strontium Radioisotopes