title: Acute inflammation initiates the regenerative response in the adult zebrafish brain.
abstract: The zebrafish regenerates its brain after injury and hence is a useful model organism to study the mechanisms enabling regenerative neurogenesis, which is poorly manifested in mammals. Yet the signaling mechanisms initiating such a regenerative response in fish are unknown. Using cerebroventricular microinjection of immunogenic particles and immunosuppression assays, we showed that inflammation is required and sufficient for enhancing the proliferation of neural progenitors and subsequent neurogenesis by activating injury-induced molecular programs that can be observed after traumatic brain injury. We also identified cysteinyl leukotriene signaling as an essential component of inflammation in the regenerative process of the adult zebrafish brain. Thus, our results demonstrate that in zebrafish, in contrast to mammals, inflammation is a positive regulator of neuronal regeneration in the central nervous system.
authors.affiliation: Deutsche Forshungsgemeinschaft-Center for Regenerative Therapies Dresden-Cluster of Excellence, Technische Universität Dresden, Fetscherstraße 105, 01307 Dresden, Germany.
authors.forename: Nikos
authors.initials: N
authors.lastname: Kyritsis
authors.forename: Caghan
authors.initials: C
authors.lastname: Kizil
authors.forename: Sara
authors.initials: S
authors.lastname: Zocher
authors.forename: Volker
authors.initials: V
authors.lastname: Kroehne
authors.forename: Jan
authors.initials: J
authors.lastname: Kaslin
authors.forename: Dorian
authors.initials: D
authors.lastname: Freudenreich
authors.forename: Anne
authors.initials: A
authors.lastname: Iltzsche
authors.forename: Michael
authors.initials: M
authors.lastname: Brand
mesh_terms: D000208:Acute Disease; D000818:Animals; D001930:Brain Injuries / Q000503:physiopathology*; D004660:Encephalitis / Q000503:physiopathology*; D015289:Leukotrienes / Q000378:metabolism; D058953:Neural Stem Cells / Q000502:physiology*; D055495:Neurogenesis; D018077:Receptors, Leukotriene / Q000378:metabolism; D012038:Regeneration; D015398:Signal Transduction; D015027:Zebrafish / Q000502:physiology*
chemical_list: D015289:Leukotrienes; D018077:Receptors, Leukotriene; C083169:leukotriene D4 receptor