title: Anti-allergic properties of a matured fruit extract of the date palm tree (Phoenix dactylifera L.) in mite-sensitized mice.
abstract: The effects of oral ingestion of a hot water extract of matured fruit of the date palm tree (Phoenix dactylifera L.) on allergic responses were investigated in mite-sensitized mice. Sneezing and nose rubbing events in mice given a date extract-added diet were significantly lower than in those given an extract-free (control) diet. The serum total and mite antigen-specific immunoglobulin (Ig) E levels, and the number of spleen interleukin-4(+)CD4(+), IgE(+)B220(+) and FcεRIα(+)CD117(+) cells was significantly lower in mice given the date extract-added diet than in those given the control diet. Chlorogenic acid, pelargonin and ferulic acid significantly reduced the number of IgE(+)B220(+) cells, while chlorogenic acid and pelargonin significantly decreased the number of FcεRIα(+)CD117(+) cells in mouse spleen cell cultures. These results suggest that some polyphenols in the date may reduce mite-induced allergic symptoms in mice via a decrease in the number of IgE-producing plasma cells and high-affinity IgE receptor-expressing mast cells.
authors.affiliation: Interdisciplinary Graduate School of Science and Technology, Shinshu University, Nagano, Japan.
authors.forename: Koji
authors.initials: K
authors.lastname: Karasawa
authors.forename: Hajime
authors.initials: H
authors.lastname: Otani
mesh_terms: D000284:Administration, Oral; D000818:Animals; D000872:Anthocyanins / Q000494:pharmacology; D018926:Anti-Allergic Agents / Q000494:pharmacology*; D039741:Antigens, Dermatophagoides / Q000276:immunology*; D028023:Arecaceae / Q000737:chemistry*; D002478:Cells, Cultured; D002726:Chlorogenic Acid / Q000494:pharmacology; D003373:Coumaric Acids / Q000494:pharmacology; D005638:Fruit; D007073:Immunoglobulin E / Q000097:blood; D015847:Interleukin-4 / Q000097:blood; D008297:Male; D008407:Mast Cells / Q000187:drug effects / Q000378:metabolism; D051379:Mice; D008807:Mice, Inbred BALB C; D008809:Mice, Inbred C3H; D010936:Plant Extracts / Q000494:pharmacology*; D059808:Polyphenols / Q000494:pharmacology; D013154:Spleen / Q000737:chemistry / Q000187:drug effects
chemical_list: D000872:Anthocyanins; D018926:Anti-Allergic Agents; D039741:Antigens, Dermatophagoides; D003373:Coumaric Acids; D010936:Plant Extracts; D059808:Polyphenols; D015847:Interleukin-4; D002726:Chlorogenic Acid; D007073:Immunoglobulin E; C004999:ferulic acid