title: A single kernel-based approach to extract drug-drug interactions from biomedical literature.
abstract: When one drug influences the level or activity of another drug this is known as a drug-drug interaction (DDI). Knowledge of such interactions is crucial for patient safety. However, the volume and content of published biomedical literature on drug interactions is expanding rapidly, making it increasingly difficult for DDIs database curators to detect and collate DDIs information manually. In this paper, we propose a single kernel-based approach to extract DDIs from biomedical literature. This novel kernel-based approach can effectively make full use of syntactic structural information of the dependency graph. In particular, our approach can efficiently represent both single subgraph topological information and the relation of two subgraphs in the dependency graph. Experimental evaluations showed that our single kernel-based approach can achieve state-of-the-art performance on the publicly available DDI corpus without exploiting multiple kernels or additional domain resources.
authors.affiliation: College of Computer Science and Technology, Dalian University of Technology, Dalian, Liaoning, China. zhyj@dlut.edu.cn
authors.forename: Yijia
authors.initials: Y
authors.lastname: Zhang
authors.forename: Hongfei
authors.initials: H
authors.lastname: Lin
authors.forename: Zhihao
authors.initials: Z
authors.lastname: Yang
authors.forename: Jian
authors.initials: J
authors.lastname: Wang
authors.forename: Yanpeng
authors.initials: Y
authors.lastname: Li
mesh_terms: D000465:Algorithms; D001185:Artificial Intelligence; D016208:Databases, Factual; D030562:Databases, Protein; D004347:Drug Interactions; D006801:Humans; D015233:Models, Statistical; D009323:Natural Language Processing; D011237:Predictive Value of Tests; D025941:Protein Interaction Mapping / Q000379:methods*; D015203:Reproducibility of Results; D012984:Software