title: Role of decreased androgens in the ovarian response to stimulation in older women.
abstract: Ovarian testosterone increases the response of antral follicles to stimulation, declines with age, and has effects mediated or potentiated by insulin-like growth hormone I (IGF-I). Increased circulating insulin and IGF-I, exogenous testosterone, and increased local ovarian testosterone concentrations due to aromatase inhibition or exogenous luteinizing hormone/human chorionic gonadotropin are all associated with an increased ovarian response to gonadotropins. These factors should be further investigated alone or in combination for enhancing oocyte yield with fertility treatments, particularly in older reproductive-age women.
authors.affiliation: Reproductive Partners Medical Group, Redondo Beach, California. Electronic address: drmeldrum@gmail.com.
authors.forename: David R
authors.initials: DR
authors.lastname: Meldrum
authors.affiliation: Department of Reproductive Medicine, University of California, San Diego, California.
authors.forename: R Jeffrey
authors.initials: RJ
authors.lastname: Chang
authors.affiliation: Department of Obstetrics, Gynecology, and Reproductive Sciences, University of California, San Francisco, California.
authors.forename: Linda C
authors.initials: LC
authors.lastname: Giudice
authors.affiliation: Institut Clinic of Gynecology, Obstetrics and Neonatology, Faculty of Medicine, Hospital Clinic, University of Barcelona, Barcelona, Spain.
authors.forename: Juan
authors.initials: J
authors.lastname: Balasch
authors.affiliation: Department of Obstetrics, Gynecology, and Reproductive Biology, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts.
authors.forename: Robert L
authors.initials: RL
authors.lastname: Barbieri
mesh_terms: D000328:Adult; D000375:Aging / Q000502:physiology*; D000728:Androgens / Q000378:metabolism*; D006063:Chorionic Gonadotropin / Q000494:pharmacology; D005260:Female; D006062:Gonadotropins / Q000494:pharmacology*; D006801:Humans; D007328:Insulin / Q000378:metabolism; D007334:Insulin-Like Growth Factor I / Q000378:metabolism; D007986:Luteinizing Hormone / Q000494:pharmacology; D008875:Middle Aged; D009865:Oocytes / Q000166:cytology / Q000187:drug effects / Q000378:metabolism; D006080:Ovarian Follicle / Q000187:drug effects* / Q000502:physiology*; D010062:Ovulation Induction; D013739:Testosterone / Q000378:metabolism / Q000494:pharmacology
chemical_list: D000728:Androgens; D006063:Chorionic Gonadotropin; D006062:Gonadotropins; D007328:Insulin; D013739:Testosterone; D007334:Insulin-Like Growth Factor I; D007986:Luteinizing Hormone