title: Schisarisanlactones A and B: a new class of nortriterpenoids from the fruits of Schisandra arisanensis.
abstract: Two novel highly oxygenated nortriterpenoids, schisarisanlactones A (1) and B (2), have been isolated from the fruits of Schisandra arisanensis, an endemic plant of Taiwan. Compounds 1 and 2 possess an unprecedented 5/5/7/5/5-fused pentacyclic ring system. The structures of both compounds were determined on the basis of spectroscopic analyses, especially 2D NMR and MS. A plausible biogenetic pathway of 1 was proposed. Schisarisanlactone A (1) showed significant anti-HIV activity.
authors.affiliation: School of Pharmacy, College of Medicine, National Taiwan University, Taipei, Taiwan.
authors.forename: I-Wen
authors.initials: IW
authors.lastname: Lo
authors.forename: Yu-Chi
authors.initials: YC
authors.lastname: Lin
authors.forename: Tzu-Ching
authors.initials: TC
authors.lastname: Liao
authors.forename: Shun-Ying
authors.initials: SY
authors.lastname: Chen
authors.forename: Pi-Han
authors.initials: PH
authors.lastname: Lin
authors.forename: Ching-Te
authors.initials: CT
authors.lastname: Chien
authors.forename: Sui-Yuan
authors.initials: SY
authors.lastname: Chang
authors.forename: Ya-Ching
authors.initials: YC
authors.lastname: Shen
mesh_terms: D019380:Anti-HIV Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D005638:Fruit / Q000737:chemistry*; D006678:HIV / Q000187:drug effects; D015394:Molecular Structure; D010936:Plant Extracts / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D032141:Schisandra / Q000737:chemistry*; D013624:Taiwan; D014315:Triterpenes / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology
chemical_list: D019380:Anti-HIV Agents; D010936:Plant Extracts; D014315:Triterpenes