title: Single nucleotide polymorphisms of the bovine VEGF-B gene and their associations with growth traits in the Nanyang cattle breed.
abstract: PCR-SSCP and DNA sequencing methods were applied to reveal single nucleotide polymorphisms (SNPs) in the bovine VEGF-B gene in 675 samples belonging to three native Chinese cattle breeds. We found 3 SNPs and a duplication NC_007330.5: g. [782 A>G p. (Gly112 =) (;) 1000-1001dup CT (;) 1079 C>T (;) 2129 G>A p. (Arg184Gln)]. We also observed a statistically significant association of the polymorphism (1000-1001dup CT) in intron 3 of the VEGF-B gene with the body weight of the Nanyang cattle (p < 0.05). This polymorphisms of VEGF-B gene need to be verified among a larger cattle population before it can be identified as a marker for bovine body weight.
authors.affiliation: College of Animal Science and Technology, Northwest A&F University, ShaanxiKey Laboratory of Molecular Biology for Agriculture, Yangling, Shaanxi, China.
authors.forename: Y H
authors.initials: YH
authors.lastname: Pang
authors.forename: C Z
authors.initials: CZ
authors.lastname: Lei
authors.forename: C L
authors.initials: CL
authors.lastname: Zhang
authors.forename: X Y
authors.initials: XY
authors.lastname: Lan
authors.forename: S M
authors.initials: SM
authors.lastname: Shao
authors.forename: X M
authors.initials: XM
authors.lastname: Gao
authors.forename: H
authors.initials: H
authors.lastname: Chen
mesh_terms: D000822:Animal Husbandry; D000818:Animals; D001835:Body Weight / Q000235:genetics; D002417:Cattle / Q000235:genetics* / Q000254:growth & development*; D002681:China; D016133:Polymerase Chain Reaction; D020641:Polymorphism, Single Nucleotide; D018807:Polymorphism, Single-Stranded Conformational; D042561:Vascular Endothelial Growth Factor B / Q000235:genetics*
chemical_list: D042561:Vascular Endothelial Growth Factor B