title: EphB4 is overexpressed in gliomas and promotes the growth of glioma cells.
abstract: Glioma is one of the most common solid tumors, and the molecular mechanism for this disease is poorly understood. EphB4 tyrosine kinase receptor has been involved in various physiologic and pathologic processes, and the role of EphB4 in tumorigenesis has recently attracted much interest. However, its function in glioma remains largely unknown. In this study, we explored the function of EphB4 in glioma. We found that the expression of EphB4 was significantly upregulated in clinical glioma samples. Overexpression of EphB4 in glioma cell lines accelerated cell growth and tumorigenesis. In contrast, downregulation of EphB4 inhibited cell growth. Furthermore, we showed that EphB4 promoted cell growth by promoting EGFR signaling. Taken together, our findings suggest that EphB4 plays an important role in the progression of glioma by stimulating cell growth and EphB4 might be a potential therapeutic target for glioma.
authors.affiliation: State Key Laboratory of Respiratory Disease for Allergy at Shengzhen University, School of Medicine, Shenzhen University, Nanhai Ave. 3688, Shenzhen, Guangdong, 518060, People's Republic of China.
authors.forename: Tao
authors.initials: T
authors.lastname: Chen
authors.forename: Xiaoyu
authors.initials: X
authors.lastname: Liu
authors.forename: Shanghui
authors.initials: S
authors.lastname: Yi
authors.forename: Jiannan
authors.initials: J
authors.lastname: Zhang
authors.forename: Jianwei
authors.initials: J
authors.lastname: Ge
authors.forename: Zhigang
authors.initials: Z
authors.lastname: Liu
mesh_terms: D001932:Brain Neoplasms / Q000235:genetics / Q000378:metabolism* / Q000473:pathology*; D045744:Cell Line, Tumor; D002465:Cell Movement; D049109:Cell Proliferation; D066246:ErbB Receptors / Q000378:metabolism; D015972:Gene Expression Regulation, Neoplastic; D005910:Glioma / Q000235:genetics / Q000378:metabolism* / Q000473:pathology*; D006801:Humans; D034622:RNA Interference; D034741:RNA, Small Interfering; D036224:Receptor, EphB4 / Q000096:biosynthesis / Q000378:metabolism*; D015398:Signal Transduction; D015854:Up-Regulation
chemical_list: D034741:RNA, Small Interfering; C512478:EGFR protein, human; D066246:ErbB Receptors; D036224:Receptor, EphB4