title: [Chronic lymphocytic leukaemia presenting with specific cutaneous infiltrates in the absence of lymphocytosis: Two cases].
abstract: BACKGROUND
  Specific cutaneous infiltrates of chronic lymphocytic leukaemia (CLL) are rare. They occur after a mean disease duration of 3 years. CLL skin infiltrates as the primary manifestation of the disease have been reported, but a normal lymphocyte count at diagnosis is rare. We present two cases of CLL initially presenting in the skin, without lymphocytosis.
  
  
  METHODS
  A 53-year-old man developed papulonodular lesions of the face and infiltrated plaques of the scalp, and an 85-year-old woman presented erythematous nodules of the face and neck. Histopathology revealed a lymphocytic infiltrate, consisting of small mature B-cells CD20+, CD79+, with an aberrant phenotype CD5+. CD23 was positive in one case. The two patients had no lymphocytosis, but immunophenotyping was characteristic of CLL. In the second case, there was a sub-mental adenopathy, histologic analysis of which was consistent with CLL. The CLL was classified as Binet stage A in the two cases. No disease progression was noted at follow-up.
  
  
  CONCLUSIONS
  The unusual feature of these cases is the lack of lymphocytosis at diagnosis. Thus, the skin lesions resulted in further evaluations for CLL, although the diagnosis was not suggested by the blood count.
  
  
  CONCLUSIONS
  Skin involvement in CLL does not appear to be a poor prognostic indicator, arguing in favour of recruitment of circulating monoclonal B-cells rather than an additional tumour mass.
authors.affiliation: Service de dermatologie, hôpital Claude-Huriez, CHRU de Lille, 59037 Lille cedex, France.
authors.forename: M
authors.initials: M
authors.lastname: Vonarx
authors.forename: O
authors.initials: O
authors.lastname: Carpentier
authors.forename: B
authors.initials: B
authors.lastname: Cazin
authors.forename: B
authors.initials: B
authors.lastname: Bouchindhomme
authors.forename: E
authors.initials: E
authors.lastname: Delaporte
mesh_terms: D000369:Aged, 80 and over; D018951:Antigens, CD20 / Q000032:analysis; D001402:B-Lymphocytes / Q000473:pathology; D018956:CD5 Antigens / Q000032:analysis; D051925:CD79 Antigens / Q000032:analysis; D005260:Female; D006801:Humans; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000175:diagnosis* / Q000473:pathology*; D017254:Leukemic Infiltration / Q000473:pathology*; D018655:Lymphocyte Count; D008218:Lymphocytosis / Q000175:diagnosis* / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D017455:Receptors, IgE / Q000032:analysis; D012867:Skin / Q000473:pathology*
chemical_list: D018951:Antigens, CD20; D018956:CD5 Antigens; D051925:CD79 Antigens; D017455:Receptors, IgE