title: No significant association between genetic variants in 7 candidate genes and response to methylphenidate treatment in adult patients with ADHD.
abstract: Results from pharmacogenetic investigations of methylphenidate (MPH) response in patients with ADHD are still inconsistent, especially among adults. This study investigates the role of genetic variants (SLC6A4, HTR1B, TPH2, DBH, DRD4, COMT, and SNAP25) in the response to MPH in a sample of 164 adults. Genes were chosen owing to previous evidence for an influence in ADHD susceptibility. No significant differences in allele or genotype frequencies between MPH responders and nonresponders were detected. In conclusion, our findings do not support an effect of these genes in the pharmacogenetics of MPH among adults with ADHD.
authors.affiliation: Department of Genetics, Instituto de Biociências, Universidade Federal do Rio Grande do Sul, Brazil.
authors.forename: Verônica
authors.initials: V
authors.lastname: Contini
authors.forename: Marcelo M
authors.initials: MM
authors.lastname: Victor
authors.forename: Guilherme P
authors.initials: GP
authors.lastname: Bertuzzi
authors.forename: Carlos A I
authors.initials: CA
authors.lastname: Salgado
authors.forename: Felipe A
authors.initials: FA
authors.lastname: Picon
authors.forename: Eugenio H
authors.initials: EH
authors.lastname: Grevet
authors.forename: Luis A
authors.initials: LA
authors.lastname: Rohde
authors.forename: Paulo
authors.initials: P
authors.lastname: Belmonte-de-Abreu
authors.forename: Claiton H D
authors.initials: CH
authors.lastname: Bau
mesh_terms: D000328:Adult; D001289:Attention Deficit Disorder with Hyperactivity / Q000188:drug therapy* / Q000235:genetics*; D000697:Central Nervous System Stimulants / Q000627:therapeutic use; D005260:Female; D005787:Gene Frequency; D056726:Genetic Association Studies / Q000379:methods*; D014644:Genetic Variation / Q000235:genetics*; D006801:Humans; D008297:Male; D008774:Methylphenidate / Q000627:therapeutic use*; D008875:Middle Aged; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D000697:Central Nervous System Stimulants; D008774:Methylphenidate