title: 6-Mercaptopurine-induced recurrent acute pancreatitis in children with acute lymphoblastic leukemia/lymphoma.
abstract: Two children with acute lymphoblastic leukemia/lymphoma developed recurrent acute pancreatitis during treatment; the etiology was presumed to be secondary to 6-mercaptopurine (6MP). Both had no further attacks after discontinuation of 6MP. Acute pancreatitis secondary to 6MP is extremely rare in acute leukemia/lymphoma although it has been reported in patients with other conditions like inflammatory bowel disease; the reason for this difference is not clearly understood.
authors.affiliation: Department of Pediatric Hematology/Oncology, King Hussein Cancer Center, Amman, Jordan.
authors.forename: Hadeel
authors.initials: H
authors.lastname: Halalsheh
authors.forename: Faiha
authors.initials: F
authors.lastname: Bazzeh
authors.forename: Khaldoun
authors.initials: K
authors.lastname: Alkayed
authors.forename: Khadra
authors.initials: K
authors.lastname: Salami
authors.forename: Faris
authors.initials: F
authors.lastname: Madanat
mesh_terms: D000293:Adolescent; D000964:Antimetabolites, Antineoplastic / Q000009:adverse effects*; D002648:Child; D006801:Humans; D008297:Male; D015122:Mercaptopurine / Q000009:adverse effects*; D010195:Pancreatitis / Q000139:chemically induced*; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000188:drug therapy*
chemical_list: D000964:Antimetabolites, Antineoplastic; D015122:Mercaptopurine