title: Chemical constituents of Machaerium hirtum Vell. (Fabaceae) leaves and branches and its anti-inflammatory activity evaluation.
abstract: Leaves and branches of Machaerium hirtum Vell. (Fabaceae), native to South America, were subjected to phytopharmacological investigation in order to identify its major chemical constituents and evaluate its extracts, fractions and isolated compounds in assays for anti-inflammatory activities. These were performed using mouse ear edema model, pleurisy and myeloperoxidase activity assays. Six compounds were isolated and identified as the flavanones swertisin and isovitexin, the alkaloid 4-hydroxy-N-methylproline, the triterpenes friedelin and lupeol, and the steroids sitosterol and stigmasterol. These compounds were identified by nuclear magnetic resonance of (1)H and (13)C data, in comparison with literature.
authors.affiliation: Departamento de Química, Universidade Estadual de Maringá, 87020-900 Maringá - PR, Brasil.
authors.forename: Marlene C
authors.initials: MC
authors.lastname: Ignoato
authors.forename: Rodrigo M
authors.initials: RM
authors.lastname: Fabrão
authors.forename: Ivânia T A
authors.initials: IT
authors.lastname: Schuquel
authors.forename: Marcos F P
authors.initials: MF
authors.lastname: Botelho
authors.forename: Geanderson
authors.initials: G
authors.lastname: Bannwart
authors.forename: Armando M
authors.initials: AM
authors.lastname: Pomini
authors.forename: Laura L M
authors.initials: LL
authors.lastname: Arruda
authors.forename: Ciomar A
authors.initials: CA
authors.lastname: Bersani-Amado
authors.forename: Silvana M O
authors.initials: SM
authors.lastname: Santin
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000737:chemistry* / Q000627:therapeutic use*; D047310:Apigenin / Q000737:chemistry / Q000627:therapeutic use; D004487:Edema / Q000188:drug therapy; D007887:Fabaceae / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D053978:Pentacyclic Triterpenes / Q000737:chemistry / Q000627:therapeutic use; D010936:Plant Extracts / Q000737:chemistry* / Q000627:therapeutic use*; D018515:Plant Leaves / Q000737:chemistry*; D011392:Proline / Q000031:analogs & derivatives / Q000737:chemistry / Q000627:therapeutic use; D012855:Sitosterols / Q000737:chemistry / Q000627:therapeutic use; D013265:Stigmasterol / Q000737:chemistry / Q000627:therapeutic use; D014315:Triterpenes / Q000737:chemistry / Q000627:therapeutic use; D000094042:Lupanes
chemical_list: D000893:Anti-Inflammatory Agents; D047310:Apigenin; D053978:Pentacyclic Triterpenes; D010936:Plant Extracts; D011392:Proline; D012855:Sitosterols; D013265:Stigmasterol; D014315:Triterpenes; C509448:4-hydroxy-N-methylproline; C556941:swertisin; C025473:gamma-sitosterol; C060796:friedelin; D000094042:Lupanes; C049772:isovitexin; C010480:lupeol