title: Association of lean and fat body mass, bone biomarkers and gonadal steroids with bone mass during pre- and midpuberty.
abstract: OBJECTIVE
  The association of bone mass with body composition, bone turnover markers and gonadal steroids was examined in Hungarian children during pre- and midpuberty.
  
  
  METHODS
  Two hundred and thirty-seven 7- to 16-year-old subjects (56% girls) were investigated. Bone mineral density (BMD), fat mass and total and appendicular lean mass were estimated with dual-energy X-ray absorptiometry (Lunar Prodigy). The fat mass index and appendicular lean mass index (LMI) were calculated. Serum bone markers, parathyroid hormone, estradiol and testosterone were analyzed. Associations between variables were evaluated by multiple regression analysis.
  
  
  RESULTS
  During prepuberty, bone biomarkers, gonadal steroids and appendicular LMI were associated with bone mass in both genders (p < 0.05). During midpuberty, girls' bone turnover markers were negatively associated with bone mass (p < 0.001). In prepuberty, appendicular LMI and β-crosslaps were predictors of bone mass in both genders. During midpuberty, appendicular LMI and gonadal steroids positively contributed to bone mass in both genders, while osteocalcin exerted a negative influence on total and L1-L4 spine BMD in girls and on L1-L4 BMD in boys (all p < 0.001).
  
  
  CONCLUSIONS
  Predictors for bone development varied according to Tanner stage and gender. The most significant determinants of bone mass were appendicular LMI and estradiol.
authors.affiliation: Department of Pediatrics, University of West Hungary-Savaria Campus, Szombathely, Hungary.
authors.forename: Violetta
authors.initials: V
authors.lastname: Csakvary
authors.forename: Eva
authors.initials: E
authors.lastname: Erhardt
authors.forename: Peter
authors.initials: P
authors.lastname: Vargha
authors.forename: Gyorgy
authors.initials: G
authors.lastname: Oroszlan
authors.forename: Tamas
authors.initials: T
authors.lastname: Bodecs
authors.forename: Dora
authors.initials: D
authors.lastname: Torok
authors.forename: Erzsebet
authors.initials: E
authors.lastname: Toldy
authors.forename: Gabor L
authors.initials: GL
authors.lastname: Kovacs
mesh_terms: D000273:Adipose Tissue / Q000033:anatomy & histology; D000293:Adolescent; D000367:Age Factors; D015415:Biomarkers / Q000097:blood* / Q000378:metabolism; D001823:Body Composition / Q000502:physiology*; D015992:Body Mass Index; D015519:Bone Density / Q000502:physiology; D001842:Bone and Bones / Q000033:anatomy & histology / Q000378:metabolism*; D002648:Child; D015331:Cohort Studies; D005260:Female; D012739:Gonadal Steroid Hormones / Q000097:blood* / Q000378:metabolism; D006801:Humans; D008297:Male; D009929:Organ Size; D011627:Puberty / Q000097:blood* / Q000378:metabolism* / Q000502:physiology; D012727:Sex Characteristics
chemical_list: D015415:Biomarkers; D012739:Gonadal Steroid Hormones