title: Two novel alleles at HLA-B locus identified in two volunteer bone marrow donors by sequence-based typing.
abstract: Two novel human leucocyte antigen (HLA) class I alleles have been identified in two Italian individuals. HLA-B*27:07:02 is identical to HLA-B*27:07:01 except for a nucleotide substitution at position 846 (A->G) resulting in a silent mutation. HLA-B*35:206 differs from the most similar allele, HLA-B*35:08:01, because of a single base mutation at position 149 (G->C) causing an aminoacidic change at codon 26 from Gly to Ala.
authors.affiliation: Organ and Tissue Transplantation Immunology, Regenerative Medicine Department, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy. sara.frison@policlinico.mi.it
authors.forename: S
authors.initials: S
authors.lastname: Frison
authors.forename: E
authors.initials: E
authors.lastname: Longhi
authors.forename: M
authors.initials: M
authors.lastname: Mantovani
authors.forename: A
authors.initials: A
authors.lastname: Malagoli
authors.forename: A
authors.initials: A
authors.lastname: De Giuli
authors.forename: G
authors.initials: G
authors.lastname: Piccolo
authors.forename: F
authors.initials: F
authors.lastname: Poli
mesh_terms: D000595:Amino Acid Sequence; D019943:Amino Acid Substitution; D001483:Base Sequence; D001853:Bone Marrow; D001854:Bone Marrow Cells / Q000166:cytology; D016026:Bone Marrow Transplantation; D015796:HLA-B27 Antigen / Q000235:genetics*; D015797:HLA-B35 Antigen / Q000235:genetics*; D006650:Histocompatibility Testing; D006801:Humans; D007558:Italy; D020641:Polymorphism, Single Nucleotide; D017422:Sequence Analysis, DNA
chemical_list: C513088:HLA-B*27:07 antigen; D015796:HLA-B27 Antigen; D015797:HLA-B35 Antigen