title: Group I metabotropic glutamate receptor-mediated gene transcription and implications for synaptic plasticity and diseases.
abstract: Stimulation of group I metabotropic glutamate receptors (mGluRs) initiates a wide variety of signaling pathways. Group I mGluR activation can regulate gene expression at both translational and transcriptional levels, and induces translation or transcription-dependent synaptic plastic changes in neurons. The group I mGluR-mediated translation-dependent neural plasticity has been well reviewed. In this review, we will highlight group I mGluR-induced gene transcription and its role in synaptic plasticity. The signaling pathways (PKA, CaMKs, and MAPKs) which have been shown to link group I mGluRs to gene transcription, the relevant transcription factors (CREB and NF-κB), and target proteins (FMRP and ARC) will be documented. The significance and future direction for characterizing group I mGluR-mediated gene transcription in fragile X syndrome, schizophrenia, drug addiction, and other neurological disorders will also be discussed.
authors.affiliation: Department of Physiology, Faculty of Medicine, University of Toronto Toronto, ON, Canada.
authors.forename: Hansen
authors.initials: H
authors.lastname: Wang
authors.forename: Min
authors.initials: M
authors.lastname: Zhuo
keywords: CREB; FMRP; fragile X syndrome; gene transcription; group I metabotropic glutamate receptors; signal transduction; synaptic plasticity