title: Genome-wide scan identifies variant in TNFSF13 associated with serum IgM in a healthy Chinese male population.
abstract: IgM provides a first line of defense during microbial infections. Serum IgM levels are detected routinely in clinical practice. And IgM is a genetically complex trait. We conducted a two-stage genome-wide association study (GWAS) to identify genetic variants affecting serum IgM levels in a Chinese population of 3495, including 1999 unrelated subjects in the first stage and 1496 independent individuals in the second stage. Our data show that a common single nucleotide polymorphism (SNP), rs11552708 located in the TNFSF13 gene was significantly associated with IgM levels (p = 5.00×10(-7) in first stage, p = 1.34×10(-3) in second stage, and p = 4.22×10(-9) when combined). Besides, smoking was identified to be associated with IgM levels in both stages (P<0.05), but there was no significant interaction between smoking and the identified SNP (P>0.05). It is suggested that TNFSF13 may be a susceptibility gene affecting serum IgM levels in Chinese male population.
authors.affiliation: Center for Genomic and Personalized Medicine, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, People's Republic of China.
authors.forename: Ming
authors.initials: M
authors.lastname: Yang
authors.forename: Yongming
authors.initials: Y
authors.lastname: Wu
authors.forename: Yanmei
authors.initials: Y
authors.lastname: Lu
authors.forename: Changyuan
authors.initials: C
authors.lastname: Liu
authors.forename: Jielin
authors.initials: J
authors.lastname: Sun
authors.forename: Ming
authors.initials: M
authors.lastname: Liao
authors.forename: Min
authors.initials: M
authors.lastname: Qin
authors.forename: Linjian
authors.initials: L
authors.lastname: Mo
authors.forename: Yong
authors.initials: Y
authors.lastname: Gao
authors.forename: Zheng
authors.initials: Z
authors.lastname: Lu
authors.forename: Chunlei
authors.initials: C
authors.lastname: Wu
authors.forename: Youjie
authors.initials: Y
authors.lastname: Zhang
authors.forename: Haiying
authors.initials: H
authors.lastname: Zhang
authors.forename: Xue
authors.initials: X
authors.lastname: Qin
authors.forename: Yanling
authors.initials: Y
authors.lastname: Hu
authors.forename: Shijun
authors.initials: S
authors.lastname: Zhang
authors.forename: Jianling
authors.initials: J
authors.lastname: Li
authors.forename: Min
authors.initials: M
authors.lastname: Dong
authors.forename: S Lilly
authors.initials: SL
authors.lastname: Zheng
authors.forename: Jianfeng
authors.initials: J
authors.lastname: Xu
authors.forename: Xiaobo
authors.initials: X
authors.lastname: Yang
authors.forename: Aihua
authors.initials: A
authors.lastname: Tan
authors.forename: Zengnan
authors.initials: Z
authors.lastname: Mo
mesh_terms: D000328:Adult; D000368:Aged; D002681:China; D055106:Genome-Wide Association Study; D005838:Genotype; D006262:Health; D006801:Humans; D007075:Immunoglobulin M / Q000097:blood*; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D053300:Tumor Necrosis Factor Ligand Superfamily Member 13 / Q000235:genetics*; D055815:Young Adult
chemical_list: D007075:Immunoglobulin M; C114631:TNFSF13 protein, human; D053300:Tumor Necrosis Factor Ligand Superfamily Member 13