title: Effects of restructured pork containing Himanthalia elongata on adipose tissue lipogenic and lipolytic enzyme expression of normo- and hypercholesterolemic rats.
abstract: BACKGROUND
  Inclusion of seaweeds in restructured pork (RP) would improve meat health properties.
  
  
  OBJECTIVE
  The aim was to determine the effects of RP containing Himanthalia elongata on growth, organ weight, cholesterolemia, and expression of lipoprotein lipase (LPL), acetyl CoA carboxylase (ACC), fatty acid synthase (FAS), and hormone-sensitive lipase (HSL) in adipose tissue of Wistar rats.
  
  
  METHODS
  The control group (C) consumed control RP, and the seaweed group (SS) consumed RP with 5% Himanthalia elongata. Animals on cholesterol-enriched diets (CholC, CholSS) consumed their corresponding basal diets with supplementary cholesterol (2.43%) plus cholic acid (0.49%) as hypercholesterolemic agents.
  
  
  RESULTS
  Seaweed inclusion did not modify cholesterolemia but reduced (p < 0.01) the hypercholesterolemic effect of dietary cholesterol plus cholic acid. CholC rats presented lower (p < 0.05) adipose fat and weight than C rats. Cholesterol feeding affected HSL, ACC, and FAS expression (p < 0.05), while alga consumption influenced HSL and ACC (p < 0.05). LPL was not significantly affected by both factors. CholSS rats showed decreased HSL and FAS (p < 0.05) but increased ACC (p < 0.05) expression compared with CholC rats.
  
  
  CONCLUSIONS
  Himanthalia RP partially blocked the dietary hypercholesterolemic effect and changed the lipogenic/lipolytic enzyme expression, reducing the wasting effect of hypercholesterolemia on adipose tissue in rats.
authors.affiliation: Departamento de Nutrición y Bromatología I, Universidad del Pais Vasco, Vitoria, Spain.
authors.forename: Laura
authors.initials: L
authors.lastname: González-Torres
authors.forename: Itziar
authors.initials: I
authors.lastname: Churruca
authors.forename: Adriana R
authors.initials: AR
authors.lastname: Schultz Moreira
authors.forename: Sara
authors.initials: S
authors.lastname: Bastida
authors.forename: Juana
authors.initials: J
authors.lastname: Benedí
authors.forename: María P
authors.initials: MP
authors.lastname: Portillo
authors.forename: Francisco J
authors.initials: FJ
authors.lastname: Sánchez-Muniz
mesh_terms: D000273:Adipose Tissue / Q000378:metabolism*; D000821:Animal Feed; D053180:Animal Nutrition Sciences; D000818:Animals; D001835:Body Weight; D002784:Cholesterol / Q000378:metabolism*; D019826:Cholic Acid / Q000378:metabolism; D064429:Fatty Acid Synthases / Q000378:metabolism; D006937:Hypercholesterolemia / Q000378:metabolism*; D008071:Lipoprotein Lipase / Q000378:metabolism; D008297:Male; D008460:Meat; D000459:Phaeophyceae / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar; D012624:Seaweed; D013552:Swine
chemical_list: D002784:Cholesterol; D064429:Fatty Acid Synthases; D008071:Lipoprotein Lipase; D019826:Cholic Acid