title: [Vitamin D and innate immunity of the skin].
abstract: Besides its role in bone metabolism vitamin D is involved in important regulatory mechanisms within the innate and adaptive immune system. In particular, vitamin D affects the production of antimicrobial peptides (AMPs). AMPs are endogenous 'antibiotics', produced my man himself with further immune regulatory functions in the skin and other epithelial surfaces. AMPs play a central role in the pathogenesis of several inflammatory skin diseases such as atopic eczema or psoriasis. Therefore, the vitamin D signal pathway could serve as a treatment target for those diseases. In this review we discuss the role of the vitamin D signalling pathway in the context of innate immunity in inflammatory skin diseases.
authors.affiliation: Klinik und Poliklinik für Dermatologie und Allergologie, Ludwig-Maximilians-Universität, München.
authors.forename: M
authors.initials: M
authors.lastname: Reinholz
authors.forename: J
authors.initials: J
authors.lastname: Schauber
mesh_terms: D016207:Cytokines / Q000276:immunology; D003872:Dermatitis / Q000188:drug therapy* / Q000276:immunology*; D006801:Humans; D007113:Immunity, Innate / Q000187:drug effects / Q000276:immunology*; D015398:Signal Transduction / Q000187:drug effects / Q000276:immunology*; D012867:Skin / Q000187:drug effects* / Q000276:immunology*; D014807:Vitamin D / Q000008:administration & dosage*
chemical_list: D016207:Cytokines; D014807:Vitamin D