title: Demographic, metabolic, and blood pressure characteristics of living kidney donors spanning five decades.
abstract: While cautious criteria for selection of living kidney donors are credited for favorable outcomes, recent practice changes may include acceptance of less than ideal donors. To characterize trends in donor acceptance, the Renal and Lung Living Donors Evaluation (RELIVE) Study evaluated 8,951 kidney donors who donated between 1963 and 2007 at three major U.S. transplant centers. Over the study interval, there was an increase in the percentage of donors >40 years old from 38% to 51%; donors >60 years varied between 1% and 4%. The proportion of donors with obesity increased from 8% to 26% and with glucose intolerance from 9% to 25%. The percentage of hypertensive donors was consistent (5-8%). Accepted donors ≥60 years old were more likely to have obesity, glucose intolerance, and/or hypertension compared to younger donors (p<0.0001). Our results demonstrate important trends in acceptance of older and more obese donors. The fraction of older donors accepted with glucose intolerance or hypertension remains small and for the majority includes mild elevations in glucose or blood pressure that were previously classified as within normal limits.
authors.affiliation: Division of Nephrology and Hypertension, Mayo Clinic, Rochester, MN, USA. taler.sandra@mayo.edu
authors.forename: S J
authors.initials: SJ
authors.lastname: Taler
authors.forename: E E
authors.initials: EE
authors.lastname: Messersmith
authors.forename: A B
authors.initials: AB
authors.lastname: Leichtman
authors.forename: B W
authors.initials: BW
authors.lastname: Gillespie
authors.forename: C E
authors.initials: CE
authors.lastname: Kew
authors.forename: M D
authors.initials: MD
authors.lastname: Stegall
authors.forename: R M
authors.initials: RM
authors.lastname: Merion
authors.forename: A J
authors.initials: AJ
authors.lastname: Matas
authors.forename: H N
authors.initials: HN
authors.lastname: Ibrahim
mesh_terms: D000328:Adult; D000368:Aged; D001794:Blood Pressure; D005260:Female; D018149:Glucose Intolerance / Q000150:complications / Q000503:physiopathology; D006801:Humans; D006973:Hypertension / Q000150:complications / Q000503:physiopathology; D016030:Kidney Transplantation / Q000379:methods*; D019520:Living Donors / Q000706:statistics & numerical data*; D008297:Male; D008875:Middle Aged; D015233:Models, Statistical; D009765:Obesity / Q000150:complications / Q000503:physiopathology; D012042:Registries; D051437:Renal Insufficiency / Q000628:therapy*; D016896:Treatment Outcome