title: CNTNAP2 is significantly associated with schizophrenia and major depression in the Han Chinese population.
abstract: CNTNAP2, located on 7q35-36.1, encodes a single-pass transmembrane protein mediating cell-cell interactions in the nervous system. CNTNAP2 has been suggested to play an important role in mental diseases such as autism and language disorder. However, we still do not know whether it also confers risk to major psychiatric disorders such as schizophrenia, major depression and bipolar disorder. We analysed single nucleotide polymorphisms (SNPs) previously reported to be associated with autism or language impairment in 1135 schizophrenia patients, 1135 unrelated major depression patients, 1135 unrelated bipolar disorder patients and 1135 unrelated normal controls recruited from the Han Chinese population. We found that the genotypes of rs17236239 were significantly associated with schizophrenia and the alleles of rs2710102 and rs2710117 were significantly associated with major depression. According to the location of significant signals, our study indicated that exon 13-15 of CNTNAP2 may play important roles in both schizophrenia and major depression in the Han Chinese population.
authors.affiliation: Shanghai Changning Mental Health Center, 299 XieHe Road, Shanghai 200042, PR China.
authors.forename: Weidong
authors.initials: W
authors.lastname: Ji
authors.forename: Tao
authors.initials: T
authors.lastname: Li
authors.forename: Yaosheng
authors.initials: Y
authors.lastname: Pan
authors.forename: Hua
authors.initials: H
authors.lastname: Tao
authors.forename: Kang
authors.initials: K
authors.lastname: Ju
authors.forename: Zujia
authors.initials: Z
authors.lastname: Wen
authors.forename: Yingchun
authors.initials: Y
authors.lastname: Fu
authors.forename: Zhiguo
authors.initials: Z
authors.lastname: An
authors.forename: Qian
authors.initials: Q
authors.lastname: Zhao
authors.forename: Ti
authors.initials: T
authors.lastname: Wang
authors.forename: Lin
authors.initials: L
authors.lastname: He
authors.forename: Guoyin
authors.initials: G
authors.lastname: Feng
authors.forename: Qizhong
authors.initials: Q
authors.lastname: Yi
authors.forename: Yongyong
authors.initials: Y
authors.lastname: Shi
mesh_terms: D000328:Adult; D000368:Aged; D044466:Asian People / Q000208:ethnology / Q000235:genetics; D003865:Major Depressive Disorder / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D005838:Genotype; D006801:Humans; D008297:Male; D008565:Membrane Proteins / Q000235:genetics*; D008875:Middle Aged; D009419:Nerve Tissue Proteins / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D012559:Schizophrenia / Q000235:genetics*; D055815:Young Adult
chemical_list: C403049:CNTNAP2 protein, human; D008565:Membrane Proteins; D009419:Nerve Tissue Proteins