title: DNA-based delivery vehicles: pH-controlled disassembly and cargo release.
abstract: Non-Watson-Crick base pairing provides an in situ approach for actuation of DNA nanostructures through responses to solution conditions. Here we demonstrate this concept by using physiologically-relevant changes in pH to regulate DNA pyramid assembly/disassembly and to control the release of protein cargo.
authors.affiliation: Department of Chemical Engineering, University of Massachusetts, Amherst, MA, USA.
authors.forename: Jung-Won
authors.initials: JW
authors.lastname: Keum
authors.forename: Harry
authors.initials: H
authors.lastname: Bermudez
mesh_terms: D002942:Circular Dichroism; D004247:DNA / Q000737:chemistry*; D031541:Fluorescence Resonance Energy Transfer; D049452:Green Fluorescent Proteins / Q000737:chemistry; D006863:Hydrogen-Ion Concentration; D049329:Nanostructures / Q000737:chemistry; D009690:Nucleic Acid Conformation; D012996:Solutions / Q000737:chemistry
chemical_list: D012996:Solutions; C485184:enhanced green fluorescent protein; D049452:Green Fluorescent Proteins; D004247:DNA