title: Head and neck squamous cell cancer: Biology (1).
abstract: This review is the first section of tumor biology pertaining to head and neck squamous cell carcinoma (SCCHN). It is intended to introduce the basic concepts of cancer biology to enhance the translational research. The basic tumour biology relates to the aberrations in the normal cell cycle. cell growth and cell death. The genetic aspects of cancer focus upon the roles of oncogenes, tumor suppressor genes and stability genes. The epigenetic mechanisms of the cancer relates to DNA methylation and histone acetylation. This review, discusses the basics of these concepts.
authors.affiliation: Dept of Otolaryngology & HNS, King Gorge Medical University & GM Associated Hospital, Shahmeena Road, Lucknow, 226 003 India.
authors.forename: Anupam
authors.initials: A
authors.lastname: Mishra
authors.forename: Amita
authors.initials: A
authors.lastname: Pandey
authors.forename: Xiaolin
authors.initials: X
authors.lastname: Nong
keywords: Cancer Biology; Squamous cell carcinoma of Head and Neck; cell grouth