title: CD3+CD8+CD161high Tc17 cells are depleted in HIV-infection.
abstract: CD8 Tc17 cells with pro-inflammatory properties have only recently been acknowledged, and Tc17 cells in HIV-infection are not described. CD3CD8CD161 Tc17 cells and the production of interleukin (IL)-17 were examined in untreated and treated HIV-infected patients, HIV-hepatitis C virus co-infected patients, and healthy controls. Depletion of CD3CD8CD161 Tc17 cells and diminished production of IL-17 in HIV-infected patients were found. The level of Tc17 cells was associated with the CD4 cell count in treated patients.
authors.affiliation: Department of Infectious Diseases, Rigshospitalet, University Hospital of Copenhagen, Denmark.
authors.forename: Julie Christine
authors.initials: JC
authors.lastname: Gaardbo
authors.forename: Hans Jakob
authors.initials: HJ
authors.lastname: Hartling
authors.forename: Kristina
authors.initials: K
authors.lastname: Thorsteinsson
authors.forename: Henrik
authors.initials: H
authors.lastname: Ullum
authors.forename: Susanne Dam
authors.initials: SD
authors.lastname: Nielsen
mesh_terms: D000328:Adult; D017252:CD3 Complex / Q000276:immunology*; D018791:CD4 Lymphocyte Count; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology*; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology*; D060085:Coinfection; D003430:Cross-Sectional Studies; D005260:Female; D015658:HIV Infections / Q000276:immunology*; D019698:Hepatitis C, Chronic / Q000276:immunology*; D006801:Humans; D020381:Interleukin-17 / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D014779:Virus Replication
chemical_list: D017252:CD3 Complex; D020381:Interleukin-17