title: Tracking the bioreduction of disulfide-containing cationic dendrimers.
abstract: Disulfides enhance the transfection efficacy and reduce the toxicity of cationic gene delivery polymers. A quantitative analysis is provided of the bioreduction of a dynamic bioreducible dendritic polycationic probe in four cell lines. Such knowledge is indispensible for understanding and optimizing bioreducible drug and gene delivery systems.
authors.affiliation: Swiss Federal Institute of Technology Zurich (ETHZ), Department of Chemistry and Applied Biosciences, Wolfgang-Pauli-Strasse 10, 8093 Zurich, Switzerland.
authors.forename: Lorine
authors.initials: L
authors.lastname: Brülisauer
authors.forename: Nadia
authors.initials: N
authors.lastname: Kathriner
authors.forename: Mark
authors.initials: M
authors.lastname: Prenrecaj
authors.forename: Marc A
authors.initials: MA
authors.lastname: Gauthier
authors.forename: Jean-Christophe
authors.initials: JC
authors.lastname: Leroux
mesh_terms: D001896:Boron Compounds / Q000737:chemistry; D018938:Caco-2 Cells; D002412:Cations / Q000737:chemistry; D045744:Cell Line, Tumor; D050091:Dendrimers / Q000737:chemistry*; D004220:Disulfides / Q000737:chemistry*; D004337:Drug Carriers / Q000737:chemistry; D006367:HeLa Cells; D006801:Humans; D018613:Microscopy, Confocal; D010084:Oxidation-Reduction; D010957:Plasmids / Q000235:genetics / Q000378:metabolism; D011073:Polyamines / Q000737:chemistry; D011108:Polymers / Q000737:chemistry; D014162:Transfection
chemical_list: C095489:4,4-difluoro-4-bora-3a,4a-diaza-s-indacene; D001896:Boron Compounds; D002412:Cations; D050091:Dendrimers; D004220:Disulfides; D004337:Drug Carriers; C104700:PAMAM Starburst; C531249:Poly(amidoamine); D011073:Polyamines; D011108:Polymers