title: Preparation of benzo[b]furans having five-membered heterocycles at the 2-position and 2-(4-Alkylcarbamoylbuta-1,3-dienyl)benzo[b]furans, and their cysteinyl leukotriene receptor (cysLT1, cysLT2) inhibitory activity.
abstract: A series of benzo[b]furan derivatives having a five-membered heterocyclic substituent at the 2-position were prepared from 2-(1-chloro-2-formylvinyl)benzo[b]furans (2) and 2-(4-alkylcarbamoylbuta-1,3-dienyl)benzo[b]furans. These 2-heterocyclic benzo[b]furans were evaluated for their cysteinyl leukotriene receptor (cysLT1, cysLT2) inhibitory activity. Several compounds showed moderate inhibition of calcium mobilization in HEK 293T-cysLT2 or CHO-cysLT1 cells.
authors.affiliation: School of Pharmaceutical Sciences, Mukogawa Women's University, 11–68 Koshien Kyuban-cho, Nishinomiya 663–8179, Japan.
authors.forename: Yukiko
authors.initials: Y
authors.lastname: Akai
authors.forename: Yukako
authors.initials: Y
authors.lastname: Tabuchi
authors.forename: Kumiko
authors.initials: K
authors.lastname: Ando
authors.forename: Azusa
authors.initials: A
authors.lastname: Ito
authors.forename: Yoko
authors.initials: Y
authors.lastname: Sakata
authors.forename: Ikuo
authors.initials: I
authors.lastname: Kawasaki
authors.forename: Takahiro
authors.initials: T
authors.lastname: Ohishi
authors.forename: Masayuki
authors.initials: M
authors.lastname: Yamashita
authors.forename: Shunsaku
authors.initials: S
authors.lastname: Ohta
authors.forename: Kiyoharu
authors.initials: K
authors.lastname: Nishide
authors.forename: Yoshitaka
authors.initials: Y
authors.lastname: Ohishi
mesh_terms: D000818:Animals; D001572:Benzofurans / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D016466:CHO Cells; D002118:Calcium / Q000378:metabolism; D006224:Cricetinae; D057809:HEK293 Cells; D006801:Humans; D020024:Leukotriene Antagonists / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D018077:Receptors, Leukotriene / Q000378:metabolism*
chemical_list: D001572:Benzofurans; D020024:Leukotriene Antagonists; D018077:Receptors, Leukotriene; C412375:cysteinyl leukotriene receptor 2; C083169:leukotriene D4 receptor; D002118:Calcium