title: Use of benzynes for the synthesis of heterocycles.
abstract: About two decades after Kobayashi's discovery in 1983 of a very mild way of generating highly reactive aryne intermediates, the synthetic community embraced o-(trimethylsilyl)aryl triflates as convenient and versatile aryne precursors for the synthesis of carbocycles and heterocycles, as well as natural products and pharmaceutically promising drug candidates. This review provides a comprehensive overview of the construction of heterocycles using Kobayashi's silylaryl triflate aryne precursors. It is organized according to the type of heterocycle generated.
authors.affiliation: Department of Chemistry, Iowa State University, Ames, IA 50011, USA.
authors.forename: Anton V
authors.initials: AV
authors.lastname: Dubrovskiy
authors.forename: Nataliya A
authors.initials: NA
authors.lastname: Markina
authors.forename: Richard C
authors.initials: RC
authors.lastname: Larock