title: [Irreversible electroporation: the new generation of local ablation techniques for renal cell carcinoma].
abstract: BACKGROUND
  Local ablation techniques are a major focus of current developments in oncology. The primary aim is to retain organs and preserve organ functions without compromising the oncological outcome.
  
  
  METHODS
  Irreversible electroporation (IRE) is a novel ablation technique that involves the application of high-voltage pulses to induce cell apoptosis without causing thermal damage to the target tissue or adjacent structures.
  
  
  OBJECTIVE
  First published in 2005 IRE is currently undergoing preclinical and clinical trials in several areas of oncology and the initial results have been promising. The IRE technique could be a significant development in ablation treatment for renal cell carcinoma (RCC) but decisive proof of its effectiveness for local RCC has not yet been provided. This study presents the results of preclinical and initial clinical trials which are discussed and compared with those of other ablation techniques in order to demonstrate the current value of IRE.
authors.affiliation: Klinik für Urologie und Kinderurologie, Universitätsklinikum Magdeburg A.ö.R., Leipziger Straße 44, 39120 Magdeburg, Deutschland. liehr@med.ovgu.de
authors.forename: U-B
authors.initials: UB
authors.lastname: Liehr
authors.forename: J J
authors.initials: JJ
authors.lastname: Wendler
authors.forename: S
authors.initials: S
authors.lastname: Blaschke
authors.forename: M
authors.initials: M
authors.lastname: Porsch
authors.forename: A
authors.initials: A
authors.lastname: Janitzky
authors.forename: D
authors.initials: D
authors.lastname: Baumunk
authors.forename: M
authors.initials: M
authors.lastname: Pech
authors.forename: F
authors.initials: F
authors.lastname: Fischbach
authors.forename: D
authors.initials: D
authors.lastname: Schindele
authors.forename: C
authors.initials: C
authors.lastname: Grube
authors.forename: J
authors.initials: J
authors.lastname: Ricke
authors.forename: M
authors.initials: M
authors.lastname: Schostak
mesh_terms: D055011:Ablation Techniques / Q000379:methods*; D002292:Carcinoma, Renal Cell / Q000628:therapy*; D053672:Electrochemotherapy / Q000379:methods*; D006801:Humans; D008113:Liver Neoplasms / Q000628:therapy*