title: Primary cutaneous aggressive epidermotropic CD8+ T-cell lymphoma: transformation from indolent to aggressive phase in association with CCR7-positive conversion.
abstract: We report a case of primary cutaneous aggressive epidermotropic CD8+ T-cell lymphoma that transformed from the indolent phase to the aggressive phase. In the aggressive phase, the patient developed numerous subcutaneous lesions on the trunk, limbs, and face. The involvement of muscle, right testis, and pharynx were also found. We immunohistochemically analyzed the expression of chemokine receptors, before and after the transformation of aggressive epidermotropic CD8+ T-cell lymphoma. The transformation was accompanied by positive conversion of CCR7. CCR7 is crucial in lymphatic cell migration and chemotaxis to lymph nodes. Therefore, its expression is likely associated with the disseminated behavior of T-cell lymphoma.
authors.affiliation: Hamamatsu University School of Medicine Hamamatsu, Shizuoka, Japan.
authors.forename: Akira
authors.initials: A
authors.lastname: Kasuya
authors.forename: Satoshi
authors.initials: S
authors.lastname: Hirakawa
authors.forename: Yoshiki
authors.initials: Y
authors.lastname: Tokura
mesh_terms: D000369:Aged, 80 and over; D018414:CD8-Positive T-Lymphocytes; D006801:Humans; D007150:Immunohistochemistry; D016410:Lymphoma, T-Cell, Cutaneous / Q000276:immunology / Q000378:metabolism / Q000473:pathology*; D008297:Male; D010641:Phenotype; D054398:Receptors, CCR4 / Q000276:immunology / Q000378:metabolism; D054400:Receptors, CCR7 / Q000276:immunology / Q000378:metabolism*; D012878:Skin Neoplasms / Q000276:immunology / Q000378:metabolism / Q000473:pathology*
chemical_list: C515354:CCR4 protein, human; C515370:CCR7 protein, human; D054398:Receptors, CCR4; D054400:Receptors, CCR7