title: Metformin decreases serum 8-hydroxy-2'-deoxyguanosine levels in polycystic ovary syndrome.
abstract: OBJECTIVE
  To learn whether metformin treatment affects oxidative stress as measured by serum concentrations of 8-hydroxy-2'-deoxyguanosine (8-OHdG).
  
  
  METHODS
  Double-blind, randomized, placebo-controlled trial.
  
  
  METHODS
  University outpatient clinic.
  
  
  METHODS
  The study cohort consisted of 50 obese women (body mass index [BMI] ≥ 27 kg/m(2)) and 60 nonobese patients (BMI <27 kg/m(2)), mean age was 27.7 ± 4.0 SD years.
  
  
  METHODS
  Randomization to receive metformin or placebo for 3 months.
  
  
  METHODS
  Serum levels of 8-OHdG before and after medical treatment.
  
  
  RESULTS
  The levels of 8-OHdG were equal at baseline in the placebo and metformin groups. Obese women had higher baseline serum concentrations of 8-OHdG. Levels of 8-OHdG were statistically significantly reduced with metformin treatment, especially in obese patients with polycystic ovary syndrome. This study was a secondary subanalysis of a previously conducted prospective multicenter, randomized, placebo-controlled study on the effects of metformin on miscarriage, pregnancy, and miscarriage rates.
  
  
  CONCLUSIONS
  Metformin treatment, compared with placebo, statistically significantly decreased 8-OHdG levels in women with polycystic ovary syndrome.
  
  
  BACKGROUND
  NCT00994812.
authors.affiliation: Department of Oncology and Radiotherapy, Oulu University Hospital and University of Oulu, Oulu, Finland. henrijuh@mail.student.oulu.fi
authors.forename: Henri
authors.initials: H
authors.lastname: Sova
authors.forename: Ulla
authors.initials: U
authors.lastname: Puistola
authors.forename: Laure
authors.initials: L
authors.lastname: Morin-Papunen
authors.forename: Peeter
authors.initials: P
authors.lastname: Karihtala
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000097:blood; D003839:Deoxyadenosines / Q000097:blood*; D004311:Double-Blind Method; D015536:Down-Regulation / Q000187:drug effects; D005260:Female; D006801:Humans; D007004:Hypoglycemic Agents; D008687:Metformin / Q000627:therapeutic use*; D011085:Polycystic Ovary Syndrome / Q000097:blood* / Q000188:drug therapy*; D016896:Treatment Outcome
chemical_list: C436623:8-hydroxy-2'-deoxyadenosine; D015415:Biomarkers; D003839:Deoxyadenosines; D007004:Hypoglycemic Agents; D008687:Metformin