title: A novel PET scanner with semiconductor detectors may improve diagnostic accuracy in the metastatic survey of head and neck cancer patients.
abstract: OBJECTIVE
  Our research group developed new PET scanner with semiconductor detectors for high spatial resolution with low scatter noise. On head and neck cancer (HNC) surgery, FDG-PET may often provide false-positive findings in cervical node involvements. Accordingly, we assessed diagnostic accuracy using this new scanner in the HNC patients as compared with the conventional lutetium oxyorthosilicate (LSO) PET.
  
  
  METHODS
  We prospectively studied FDG imaging in 35 HNC patients by both semiconductor PET and LSO-PET. At 60 min after (18)F-FDG injection, two PET scans were obtained using both scanners consecutively and in random order. Two nuclear medicine specialists scored FDG abnormalities using 5 point scale system for receiver operating characteristic (ROC) curve analysis.
  
  
  RESULTS
  63 suspected of metastatic or recurrent lesions were evaluated and correlated by the final confirmation by pathological findings or clinical courses (malignant 26/benign 37). Semiconductor PET showed sensitivity of 92.3 % (24/26), specificity of 51.4 % (19/37), and accuracy of 68.2 % (43/63), while LSO-PET showed sensitivity of 84.6 % (22/26), specificity of 16.2 %(6/37), and accuracy of 44.4 % (28/63), respectively. Especially, semiconductor PET accurately diagnosed as true negative in the 13 of 14 lesions only detected by LSO-PET. ROC analyses revealed the diagnostic superiority of semiconductor PET from location of- and area under curve particularly in the study of small (≤10 mm) lesions.
  
  
  CONCLUSIONS
  A new novel semiconductor PET scanner can increase diagnostic accuracy with reduction in false positive findings in the HNC patients mainly due to higher spatial resolution and lower noise than the LSO-PET. This new technology can lead to more accurate diagnosis and the more optimal therapeutic tactics in head and neck surgery.
authors.affiliation: Department of Nuclear Medicine, Graduate School of Medicine, Hokkaido University, Kita-ku, Sapporo, Japan.
authors.forename: Toshiki
authors.initials: T
authors.lastname: Takei
authors.forename: Tohru
authors.initials: T
authors.lastname: Shiga
authors.forename: Yuichi
authors.initials: Y
authors.lastname: Morimoto
authors.forename: Wataru
authors.initials: W
authors.lastname: Takeuchi
authors.forename: Kikuo
authors.initials: K
authors.lastname: Umegaki
authors.forename: Kazuki
authors.initials: K
authors.lastname: Matsuzaki
authors.forename: Shozo
authors.initials: S
authors.lastname: Okamoto
authors.forename: Keiichi
authors.initials: K
authors.lastname: Magota
authors.forename: Toshihiro
authors.initials: T
authors.lastname: Hara
authors.forename: Satoshi
authors.initials: S
authors.lastname: Fukuda
authors.forename: Nagara
authors.initials: N
authors.lastname: Tamaki
mesh_terms: D003625:Data Collection; D005260:Female; D006258:Head and Neck Neoplasms / Q000000981:diagnostic imaging* / Q000473:pathology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009362:Neoplasm Metastasis; D049268:Positron-Emission Tomography / Q000295:instrumentation*; D012372:ROC Curve; D012666:Semiconductors