title: Evaluation of appetite-stimulating hormones in prepubertal children with epilepsy during topiramate treatment.
abstract: We investigated the mechanism of topiramate-related appetite loss and exposed its relationship to body weight, body mass index, body fat index, and serum insulin, lipid, leptin, neuropeptide-Y, cortisol, ghrelin, and adiponectin levels. Twenty children with epilepsy were evaluated at baseline and months 3 and 6 of treatment. Their body fat index, leptin, and neuropeptide-Y levels significantly decreased at month 3, whereas significant decreases occurred in body weight, body mass index, body fat index, neuropeptide-Y, cholesterol, and cortisol levels of patients at month 6 compared with baseline. Weight loss during topiramate treatment was attributed to loss of appetite and reduced food intake caused by reductions in neuropeptide-Y. To the best of our knowledge, this study is the first to describe reductions in neuropeptide-Y with topiramate use in humans.
authors.affiliation: Division of Pediatric Neurology, Department of Pediatrics, Mersin University School of Medicine, Mersin, Turkey.
authors.forename: Cetin
authors.initials: C
authors.lastname: Okuyaz
authors.forename: Onur
authors.initials: O
authors.lastname: Kursel
authors.forename: Mustafa
authors.initials: M
authors.lastname: Komur
authors.forename: Lulufer
authors.initials: L
authors.lastname: Tamer
mesh_terms: D052242:Adiponectin / Q000097:blood*; D050154:Adiposity / Q000187:drug effects; D000927:Anticonvulsants / Q000494:pharmacology / Q000627:therapeutic use*; D001066:Appetite / Q000187:drug effects; D015992:Body Mass Index; D001835:Body Weight / Q000187:drug effects; D002648:Child; D004827:Epilepsy / Q000097:blood* / Q000188:drug therapy; D005260:Female; D005632:Fructose / Q000031:analogs & derivatives* / Q000494:pharmacology / Q000627:therapeutic use; D054439:Ghrelin / Q000097:blood*; D006801:Humans; D007328:Insulin / Q000097:blood; D020738:Leptin / Q000097:blood; D008297:Male; D009478:Neuropeptide Y / Q000097:blood*; D000077236:Topiramate
chemical_list: D052242:Adiponectin; D000927:Anticonvulsants; D054439:Ghrelin; D007328:Insulin; D020738:Leptin; D009478:Neuropeptide Y; D000077236:Topiramate; D005632:Fructose