title: Maturation-promoting activity of SATB1 in MGE-derived cortical interneurons.
abstract: The generation of cortical interneuron subtypes is controlled by genetic programs that are activated in the ventral forebrain and unfold during the prolonged period of inhibitory neuron development. The LIM-homeodomain protein LHX6 is critical for the development of all cortical interneurons originating in the medial ganglionic eminence, but the molecular mechanisms that operate downstream of LHX6 to control the terminal differentiation of somatostatin- and parvalbumin-expressing interneurons within the cortex remain unknown. Here, we provide evidence that the nuclear matrix and genome organizer protein SATB1 is induced by neuronal activity and functions downstream of Lhx6 to control the transition of tangentially migrating immature interneurons into the terminally differentiated Somatostatin (SST)-expressing subtype. Our experiments provide a molecular framework for understanding the genetic and epigenetic mechanisms by which specified but immature cortical interneurons acquire the subtype-defining molecular and morphophysiological characteristics that allow them to integrate and function within cortical circuits.
authors.affiliation: Division of Molecular Neurobiology, MRC National Institute for Medical Research, The Ridgeway, Mill Hill, NW7 1AA London, United Kingdom.
authors.forename: Myrto
authors.initials: M
authors.lastname: Denaxa
authors.forename: Melanie
authors.initials: M
authors.lastname: Kalaitzidou
authors.forename: Anna
authors.initials: A
authors.lastname: Garefalaki
authors.forename: Angeliki
authors.initials: A
authors.lastname: Achimastou
authors.forename: Reena
authors.initials: R
authors.lastname: Lasrado
authors.forename: Tamara
authors.initials: T
authors.lastname: Maes
authors.forename: Vassilis
authors.initials: V
authors.lastname: Pachnis
mesh_terms: D000818:Animals; D002454:Cell Differentiation; D002478:Cells, Cultured; D002540:Cerebral Cortex / Q000166:cytology* / Q000196:embryology / Q000378:metabolism; D004622:Embryo, Mammalian / Q000378:metabolism; D053595:Embryonic Stem Cells / Q000166:cytology / Q000378:metabolism; D020869:Gene Expression Profiling; D005968:Glutamate Decarboxylase / Q000235:genetics / Q000378:metabolism; D007395:Interneurons / Q000378:metabolism*; D060850:LIM-Homeodomain Proteins / Q000378:metabolism; D036961:Matrix Attachment Region Binding Proteins / Q000037:antagonists & inhibitors / Q000235:genetics / Q000378:metabolism*; D051379:Mice; D009419:Nerve Tissue Proteins / Q000378:metabolism; D034622:RNA Interference; D034741:RNA, Small Interfering / Q000378:metabolism; D013004:Somatostatin / Q000378:metabolism; D014157:Transcription Factors / Q000378:metabolism
chemical_list: C498504:LHX6 protein, mouse; D060850:LIM-Homeodomain Proteins; D036961:Matrix Attachment Region Binding Proteins; D009419:Nerve Tissue Proteins; D034741:RNA, Small Interfering; C469541:Satb1 protein, mouse; D014157:Transcription Factors; D013004:Somatostatin; D005968:Glutamate Decarboxylase; C402565:glutamate decarboxylase 1