title: Formulation and evaluation of floating matrix tablet of stavudine.
abstract: OBJECTIVE
  The purpose of the study was to prolong the gastric residence time of stavudine by designing its floating tablets and to study the influence of different polymers on its release rate.
  
  
  METHODS
  The floating mix matrix tablets of stavudine were prepared by melt granulation method. Beeswax was used as hydrophobic meltable material. Hydroxypropyl methylcellulose (HPMC), sodium bicarbonate, and ethyl cellulose were used as matrixing agent, gas generating agent, and floating enhancer, respectively. The prepared tablets were evaluated for physicochemical parameters such as hardness, weight variation, friability, floating properties (floating lag time, total floating time), drug content, stability study, and in vitro drug release. The drug- polymer interaction was studied by Differential Scanning Calorimetry (DSC) thermal analysis and Fourier transform infared (FT-IR).
  
  
  RESULTS
  The floating lag time of all the formulations was within the prescribed limit (<3 min). All the formulations showed good matrix integrity and retarded the release of drug for 12 h except the formulation F5.The concentration of beeswax (X(1)), HPMC K(4)M (X(2)), and ethyl cellulose (X(3)) were selected as independent variables and drug release values at 1 (Q(1)), at 6 (Q(6)) and at 12 h (Q(12)) as dependent variables. Formulation F7 was selected as an optimum formulation as it showed more similarity in dissolution profile with theoretical profile (similarity factor, f(2) = 70.91). The dissolution of batch F7 can be described by zero-order kinetics (R(2) =0.9936) with anomalous (non-Fickian) diffusion as the release mechanism (n=0.545). There was no difference observed in release profile after temperature sensitivity study at 40°C/75% relative humidity (RH) for 1 month.
  
  
  CONCLUSIONS
  It can be concluded from this study that the combined mix matrix system containing hydrophobic and hydrophilic polymer minimized the burst release of drug from the tablet and achieved a drug release by zero-order kinetics, which is practically difficult with only hydrophilic matrix.
authors.affiliation: Department of Pharmaceutics and Pharm Technology, Shri Sarvajanik Pharmacy College, Near Arvind Baug, Mehsana- 384 001, Gujarat, India.
authors.forename: Pankaj H
authors.initials: PH
authors.lastname: Prajapati
authors.forename: Vijay V
authors.initials: VV
authors.lastname: Nakum
authors.forename: Chhagan N
authors.initials: CN
authors.lastname: Patel
keywords: Antiretroviral agent; HPMC; bees wax; in vitro buoyancy; melt granulation technology