title: Inflammatory events at blood-brain barrier in neuroinflammatory and neurodegenerative disorders: implications for clinical disease.
abstract: Proper function of the neurovasculature is required for optimal brain function and preventing neuroinflammation and neurodegeneration. Within this review, we discuss alterations of the function of the blood-brain barrier in neurologic disorders such as multiple sclerosis, epilepsy, and Alzheimer's disease and address potential underlying mechanisms.
authors.affiliation: Blood-Brain Barrier Research Group, Department of Molecular Cell Biology and Immunology, VU University Medical Center Amsterdam, Amsterdam, The Netherlands. he.devries@vumc.nl
authors.forename: Helga E
authors.initials: HE
authors.lastname: de Vries
authors.forename: Gijs
authors.initials: G
authors.lastname: Kooij
authors.forename: Dan
authors.initials: D
authors.lastname: Frenkel
authors.forename: Spiros
authors.initials: S
authors.lastname: Georgopoulos
authors.forename: Alon
authors.initials: A
authors.lastname: Monsonego
authors.forename: Damir
authors.initials: D
authors.lastname: Janigro
mesh_terms: D000818:Animals; D001812:Blood-Brain Barrier / Q000503:physiopathology*; D001921:Brain / Q000473:pathology* / Q000503:physiopathology*; D006801:Humans; D019636:Neurodegenerative Diseases / Q000473:pathology* / Q000503:physiopathology*