title: The role of BCS (biopharmaceutics classification system) and BDDCS (biopharmaceutics drug disposition classification system) in drug development.
abstract: Biopharmaceutics Classification System and Biopharmaceutics Drug Distribution Classification System are complimentary, not competing, classification systems that aim to improve, simplify, and speed drug development. Although both systems are based on classifying drugs and new molecular entities into four categories using the same solubility criteria, they differ in the criterion for permeability and have different purposes. Here, the details and applications of both systems are reviewed with particular emphasis of their role in drug development.
authors.affiliation: Department of Bioengineering and Therapeutic Sciences, Schools of Pharmacy and Medicine, University of California San Francisco, San Francisco, California 94143-0912, USA. leslie.benet@ucsf.edu
authors.forename: Leslie Z
authors.initials: LZ
authors.lastname: Benet
mesh_terms: D000042:Absorption; D000818:Animals; D001702:Biopharmaceutics / Q000145:classification*; D001921:Brain / Q000378:metabolism; D055808:Drug Discovery / Q000145:classification*; D004347:Drug Interactions; D064420:Drug-Related Side Effects and Adverse Reactions; D006801:Humans; D006863:Hydrogen-Ion Concentration; D010539:Permeability; D004364:Pharmaceutical Preparations / Q000737:chemistry / Q000145:classification* / Q000378:metabolism; D012995:Solubility; D009626:Terminology as Topic; D014018:Tissue Distribution
chemical_list: D004364:Pharmaceutical Preparations