title: [Relationship between short-term exposure to atmospheric sulfur dioxide and obstructive lesions in acute coronary syndrome].
abstract: OBJECTIVE
  Urban air pollutants are composed of a heterogeneous mixture of substances in gas and aerosol states. The aim of this study was to compare the effects caused by exposure to contaminants in the gas phase and atmospheric particles in ambient air in patients hospitalized for acute coronary syndrome (ACS) regarding the presence or absence of significant obstructive lesions (SOL) in epicardial coronary arteries.
  
  
  METHODS
  Prospectively analyzed a total of 2,110 patients with a diagnosis of ACS. We determined the mean concentrations of contaminants in the gas phase and atmospheric particles from the day before until 7 days prior to admission (1 to 7 days lag time). We divided the study population into those with presence or absence of SOL.
  
  
  RESULTS
  Of the 2,110 patients with ACS, 1,892 presented SOL and 218 without SOL. When comparing the concentrations of contaminants in the gas phase, we observed that the sulfur dioxide in patients with SOL had a trend toward higher values (10.93 ± 8.33 versus 9.31 ± 6.77 μg/m(3); P = .004). Multivariate analysis shows that for every 10 μg/m(3) increase of sulfur dioxide, there is an increase in the risk of hospitalization for ACS with SOL a 41% (odds ratio 1.41; 95% confidence interval 1.039-1.931; P = .028).
  
  
  CONCLUSIONS
  In our study population, exposure to high concentrations of sulfur dioxide is a precipitating factor for admission of patients with ACS and SOL.
authors.affiliation: Servicio de Cardiología, Hospital Universitario de Canarias, La Laguna, Santa Cruz de Tenerife, España. adrvdg@hotmail.com
authors.forename: Alberto
authors.initials: A
authors.lastname: Domínguez-Rodríguez
authors.forename: Javier
authors.initials: J
authors.lastname: Abreu-Afonso
authors.forename: Yenny
authors.initials: Y
authors.lastname: González
authors.forename: Sergio
authors.initials: S
authors.lastname: Rodríguez
authors.forename: Ruben A
authors.initials: RA
authors.lastname: Juárez-Prera
authors.forename: Eduardo
authors.initials: E
authors.lastname: Arroyo-Ucar
authors.forename: Alejandro
authors.initials: A
authors.lastname: Jiménez-Sosa
authors.forename: Pedro
authors.initials: P
authors.lastname: Abreu-González
authors.forename: Pablo
authors.initials: P
authors.lastname: Avanzas
mesh_terms: D054058:Acute Coronary Syndrome / Q000453:epidemiology / Q000209:etiology* / Q000473:pathology; D000368:Aged; D000393:Air Pollutants / Q000032:analysis / Q000633:toxicity*; D002391:Catchment Area, Health; D017023:Coronary Angiography; D023921:Coronary Stenosis / Q000000981:diagnostic imaging / Q000453:epidemiology / Q000209:etiology*; D004305:Dose-Response Relationship, Drug; D004781:Environmental Exposure; D004784:Environmental Monitoring; D005260:Female; D005740:Gases / Q000633:toxicity; D006760:Hospitalization; D006785:Hospitals, University / Q000706:statistics & numerical data; D006801:Humans; D008297:Male; D008685:Meteorological Concepts; D008875:Middle Aged; D052638:Particulate Matter / Q000032:analysis / Q000633:toxicity*; D011446:Prospective Studies; D012307:Risk Factors; D013030:Spain / Q000453:epidemiology; D013458:Sulfur Dioxide / Q000032:analysis / Q000633:toxicity*; D013997:Time Factors; D014505:Urban Population
chemical_list: D000393:Air Pollutants; D005740:Gases; D052638:Particulate Matter; D013458:Sulfur Dioxide