title: Immunization with adenoviral-vectored tick salivary gland proteins (SALPs) in a murine model of Lyme borreliosis.
abstract: Prior exposure of vertebrate hosts to tick salivary proteins can induce specific immunity to tick infestation, as well as affording protection against tick-transmitted Borrelia burgdorferi infection in the mammalian host. Vaccination using an adenovirus expression system to deliver 4 tick salivary proteins (Ad-Salps) derived from Ixodes scapularis, Salp15, Salp25A, Salp25D, and Isac, was explored. Results indicate that vaccination with tick salivary proteins in an adenoviral vector can be used to modulate a Th1 response in the host and partially control spirochete load in immunized mice after infected tick challenge.
authors.affiliation: Centers for Disease Control and Prevention, Division of Vector-Borne Diseases, Bacterial Disease Branch, 3156 Rampart Road, Fort Collins, CO 80521, USA. aff1@cdc.gov
authors.forename: A J
authors.initials: AJ
authors.lastname: Ullmann
authors.forename: M C
authors.initials: MC
authors.lastname: Dolan
authors.forename: C A
authors.initials: CA
authors.lastname: Sackal
authors.forename: E
authors.initials: E
authors.lastname: Fikrig
authors.forename: J
authors.initials: J
authors.lastname: Piesman
authors.forename: N S
authors.initials: NS
authors.lastname: Zeidner
mesh_terms: D000256:Adenoviridae / Q000235:genetics*; D000818:Animals; D060829:Arthropod Proteins / Q000235:genetics / Q000276:immunology; D006321:Heart / Q000382:microbiology; D018884:Ixodes / Q000378:metabolism* / Q000382:microbiology; D008193:Lyme Disease / Q000635:transmission*; D051379:Mice; D012471:Salivary Proteins and Peptides / Q000276:immunology* / Q000378:metabolism; D013984:Tick Infestations / Q000517:prevention & control*; D001743:Urinary Bladder / Q000382:microbiology; D014612:Vaccines / Q000276:immunology*
chemical_list: D060829:Arthropod Proteins; D012471:Salivary Proteins and Peptides; D014612:Vaccines