title: A facile synthesis of 5'-fluoro-5'-deoxyacadesine (5'-F-AICAR): a novel non-phosphorylable AICAR analogue.
abstract: The substitution of a hydroxyl group by a fluorine atom in a potential drug is an efficient reaction that can, in principle, improve its pharmacological properties. Herein,  the synthesis of the novel compound 5'-fluoro-5'-deoxyacadesine (5'-F-AICAR), a strict analogue of AICAR that cannot be 5'-phosphorylated to ZMP by cellular kinases, is reported.
authors.affiliation: Dipartimento di Chimica delle Sostanze Naturali, Università degli Studi di Napoli Federico II, Via D. Montesano 49, 80131 Napoli, Italy.
authors.forename: Stefano
authors.initials: S
authors.lastname: D'Errico
authors.forename: Giorgia
authors.initials: G
authors.lastname: Oliviero
authors.forename: Nicola
authors.initials: N
authors.lastname: Borbone
authors.forename: Jussara
authors.initials: J
authors.lastname: Amato
authors.forename: Daniele
authors.initials: D
authors.lastname: D'Alonzo
authors.forename: Vincenzo
authors.initials: V
authors.lastname: Piccialli
authors.forename: Luciano
authors.initials: L
authors.lastname: Mayol
authors.forename: Gennaro
authors.initials: G
authors.lastname: Piccialli
mesh_terms: D020536:Enzyme Activators / Q000138:chemical synthesis*; D054879:Halogenation; D010766:Phosphorylation; D011684:Purine Nucleosides / Q000737:chemistry; D012263:Ribonucleosides / Q000138:chemical synthesis*
chemical_list: C579368:5'-fluoro-5'-deoxyacadesine; D020536:Enzyme Activators; D011684:Purine Nucleosides; D012263:Ribonucleosides