title: Modulatory effects of curcumin and green tea extract against experimentally induced pulmonary fibrosis: a comparison with N-acetyl cysteine.
abstract: The study was aimed to investigate the protective effect of green tea extract (GTE), curcumin, and N-acetyl cysteine (NAC) on experimentally induced pulmonary fibrosis. Curcumin (200 mg/kg b.w), GTE (150 mg/kg b.w), and NAC (490 mg/kg b.w) were administered orally for 14 days with concomitant administration of cyclophosphamide (CP). Lung fibrosis was assessed by measuring hydroxyproline and elastin levels and confirmed by histopathological examination. Oxidative stress was also observed in the CP group. Lung myeloperoxidase activity was significantly decreased in animals of the CP group. N-acetyl-β-d-glucosaminidase, leukotriene C₄, and protein were increased in bronchoalveolar lavage fluid (BALF). Transforming growth factor-β, interleukin -1β, and histamine were increased in both serum and BALF. All modulators markedly attenuated the altered biochemical parameters as compared to CP-treated rats. These results suggest the possibility of using these treatments as protective agents with chemotherapy and as protective agents for lung fibrosis.
authors.affiliation: Faculty of Pharmacy, Cairo University, Cairo 01005366430, Egypt.
authors.forename: Mohammed Ahmed
authors.initials: MA
authors.lastname: Hamdy
authors.forename: Shohda A
authors.initials: SA
authors.lastname: El-Maraghy
authors.forename: Mona Abd El Aziz
authors.initials: MA
authors.lastname: Kortam
mesh_terms: D000111:Acetylcysteine / Q000627:therapeutic use*; D000818:Animals; D015415:Biomarkers / Q000032:analysis / Q000097:blood / Q000378:metabolism; D001992:Bronchoalveolar Lavage Fluid / Q000737:chemistry; D028241:Camellia sinensis / Q000737:chemistry*; D003474:Curcumin / Q000627:therapeutic use*; D003520:Cyclophosphamide; D019587:Dietary Supplements; D004195:Disease Models, Animal; D018836:Inflammation Mediators / Q000032:analysis / Q000097:blood / Q000378:metabolism; D015227:Lipid Peroxidation / Q000187:drug effects; D008168:Lung / Q000276:immunology / Q000378:metabolism / Q000473:pathology; D008297:Male; D010936:Plant Extracts / Q000627:therapeutic use*; D018515:Plant Leaves / Q000737:chemistry*; D020011:Protective Agents / Q000627:therapeutic use*; D011658:Pulmonary Fibrosis / Q000276:immunology / Q000378:metabolism / Q000473:pathology / Q000517:prevention & control*; D051381:Rats; D017208:Rats, Wistar; D013662:Tea / Q000737:chemistry
chemical_list: D015415:Biomarkers; D018836:Inflammation Mediators; D010936:Plant Extracts; D020011:Protective Agents; D013662:Tea; D003520:Cyclophosphamide; D003474:Curcumin; D000111:Acetylcysteine