title: A Caenorhabditis elegans insulin-like peptide, INS-17: its physiological function and expression pattern.
abstract: The insulin/insulin-like growth factor-1 signaling pathway of Caenorhabditis elegans regulates larval diapause and adult lifespan through the sole insulin receptor-like protein, DAF-2. In the present study, the physiological function and expression pattern of INS-17, one of the C. elegans insulin-like peptides, were examined by disruption and overexpression of the gene, and by the use of a reporter gene. INS-17 might function as a DAF-2 antagonist in the regulation of larval diapause, but not of the adult lifespan. The reporter protein was intensively expressed during larval diapause. It showed a drastic decrease in amount after larval diapause, which matches well the physiological function of INS-17.
authors.affiliation: Department of Bioresources Science, The United Graduate School of Agricultural Sciences, Tottori University, 4-101 Koyama-cho, Tottori 680-8553, Japan.
authors.forename: Yohei
authors.initials: Y
authors.lastname: Matsunaga
authors.forename: Kensuke
authors.initials: K
authors.lastname: Nakajima
authors.forename: Keiko
authors.initials: K
authors.lastname: Gengyo-Ando
authors.forename: Shohei
authors.initials: S
authors.lastname: Mitani
authors.forename: Takashi
authors.initials: T
authors.lastname: Iwasaki
authors.forename: Tsuyoshi
authors.initials: T
authors.lastname: Kawano
mesh_terms: D000818:Animals; D017173:Caenorhabditis elegans / Q000235:genetics / Q000378:metabolism*; D029742:Caenorhabditis elegans Proteins / Q000235:genetics* / Q000378:metabolism*; D005786:Gene Expression Regulation; D061385:Insulins / Q000235:genetics / Q000378:metabolism*; D017384:Sequence Deletion; D014158:Transcription, Genetic
chemical_list: D029742:Caenorhabditis elegans Proteins; C581092:INS-17 protein, C elegans; D061385:Insulins