title: Myocardial deformation in the fetal single ventricle.
abstract: BACKGROUND
  In postnatal life, patients with single ventricle (SV) with morphologic right ventricles have a worse prognosis than those with morphologic left ventricles. The aim of this study was to test the hypotheses that (1) the SV in fetuses with SV has decreased longitudinal strain compared with fetuses with normal cardiac anatomy, and (2) fetuses with SV right ventricular (RV) morphology have decreased strain compared with those with SV left ventricular (LV) morphology.
  
  
  METHODS
  Fetal echocardiograms with SV RV and SV LV morphology were retrospectively compiled. Postprocessing analysis of the dominant ventricle was done using syngo Velocity Vector Imaging version 2.0. Peak global longitudinal strain (GLS) and global longitudinal strain rate (GL SR) were generated. Both the right and left ventricles were analyzed in fetuses with normal cardiac anatomy for comparison.
  
  
  RESULTS
  Fifty-four fetuses with SV (18 with LV morphology and 36 with RV morphology) were included in the study and compared with 54 controls matched for gestational age. Global longitudinal strain and GL SR were compared between fetuses with SV and normal fetuses and among SV subsets. When all four categories were compared (normal left ventricle, normal right ventricle, SV left ventricle, and SV right ventricle), there was no difference in GLS (P = .49) or in GL SR (P = .32) between any of the categories.
  
  
  CONCLUSIONS
  Comparable GLS and GL SR values between fetal SV of LV or RV morphology, as well as normal fetal left and right ventricles, reflect in utero preservation of systolic function of the SV heart.
authors.affiliation: Division of Pediatric Cardiology, Children's Hospital Colorado, The University of Colorado Medical Center, Aurora, Colorado, USA.
authors.forename: Uyen T
authors.initials: UT
authors.lastname: Truong
authors.forename: Heather Y
authors.initials: HY
authors.lastname: Sun
authors.forename: Theresa A
authors.initials: TA
authors.lastname: Tacy
mesh_terms: D003937:Diagnosis, Differential; D004452:Echocardiography / Q000379:methods*; D005260:Female; D005318:Fetal Heart / Q000000981:diagnostic imaging* / Q000503:physiopathology; D006330:Heart Defects, Congenital / Q000000981:diagnostic imaging / Q000196:embryology* / Q000503:physiopathology; D006352:Heart Ventricles / Q000002:abnormalities* / Q000000981:diagnostic imaging / Q000503:physiopathology; D006801:Humans; D009200:Myocardial Contraction; D011247:Pregnancy; D012372:ROC Curve; D012189:Retrospective Studies; D016216:Ultrasonography, Prenatal / Q000379:methods*