title: Tandem chain extension-Mannich reaction: an approach to β-proline derivatives.
abstract: A zinc carbenoid-initiated chain extension reaction provides access to an organometallic intermediate, which can be used to capture activated imines. Deprotection of the nitrogen and reduction provides access to racemic derivatives of β-proline. The relative stereochemistry of the β-proline can be controlled through use of different activating groups on the imine nitrogen.
authors.affiliation: Department of Chemistry, University of New Hampshire, Durham, NH 03824.
authors.forename: Alexander M
authors.initials: AM
authors.lastname: Jacobine
authors.forename: Angela L A
authors.initials: AL
authors.lastname: Puchlopek
authors.forename: Charles K
authors.initials: CK
authors.lastname: Zercher
authors.forename: Jon B
authors.initials: JB
authors.lastname: Briggs
authors.forename: Jerry P
authors.initials: JP
authors.lastname: Jasinski
authors.forename: Raymond J
authors.initials: RJ
authors.lastname: Butcher