title: [Association between left ventricular twist/untwist and diastolic dysfunction of high cardiovascular risk population in the community].
abstract: OBJECTIVE
  To assess the association between left ventricular (LV) twist and untwist with the severity of diastolic dysfunction of high cardiovascular risk population in the community.
  
  
  METHODS
  This cross-sectional survey was performed in high cardiovascular risk people with normal left ventricular (LV) ejection fraction in an urban community of Beijing (n = 620). Normal LV diastolic function was defined in 305 subjects, mild diastolic dysfunction in 266 subjects and moderate/severe diastolic dysfunction in 49 subjects. Peak LV twist, peak twist velocity, peak untwist velocity and untwist rate were measured in apical and basal short-axis images using speckle tracking echocardiography.
  
  
  RESULTS
  Peak LV twist was similar among subjects with normal diastolic function, mild diastolic dysfunction and moderate/severe diastolic dysfunction. Peak twist velocity [(129.3 ± 45.3)°/s vs. (118.0 ± 36.2)°/s] and untwist velocity [(-132.9 ± 50.4) °/s vs. (-121.2 ± 41.4)°/s] were significantly higher in mild diastolic dysfunction group than in normal diastolic function group (all P < 0.01) and similar between normal diastolic function and moderate/severe diastolic dysfunction group (P > 0.05). Untwist rate of moderate/severe diastolic dysfunction decreased significantly than that of normal diastolic function [(41.9 ± 32.9)°/s vs. (57.7 ± 36.2) °/s, P < 0.01] and mild diastolic dysfunction group [(41.9 ± 32.9)°/s vs. (60.9 ± 39.9) °/s, P < 0.01].
  
  
  CONCLUSIONS
  Twist and untwist parameters are increased/preserved in population with normal systolic function and mild diastolic dysfunction and "normalized" or reduced in those with advanced diastolic dysfunction. The maintaining (if not increasing) of LV twist in early diastolic dysfunction might serve as a compensatory mechanism in case of reduced myocardial relaxation in these subjects.
authors.affiliation: Department of Cardiology, Peking University First Hospital, Beijing, China.
authors.forename: Guo-xiang
authors.initials: GX
authors.lastname: Wu
authors.forename: Ying
authors.initials: Y
authors.lastname: Yang
authors.forename: Bao-wei
authors.initials: BW
authors.lastname: Zhang
authors.forename: Li-tong
authors.initials: LT
authors.lastname: Qi
authors.forename: Feng
authors.initials: F
authors.lastname: Chen
authors.forename: Shu-yu
authors.initials: SY
authors.lastname: Wang
authors.forename: Li-sheng
authors.initials: LS
authors.lastname: Liu
authors.forename: Feng
authors.initials: F
authors.lastname: Zhao
authors.forename: Yong
authors.initials: Y
authors.lastname: Huo
mesh_terms: D000368:Aged; D002318:Cardiovascular Diseases / Q000000981:diagnostic imaging / Q000453:epidemiology / Q000503:physiopathology*; D002681:China / Q000453:epidemiology; D003430:Cross-Sectional Studies; D003971:Diastole; D004452:Echocardiography / Q000379:methods; D005260:Female; D006352:Heart Ventricles / Q000000981:diagnostic imaging / Q000503:physiopathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D012307:Risk Factors; D018487:Ventricular Dysfunction, Left / Q000000981:diagnostic imaging / Q000453:epidemiology / Q000503:physiopathology*; D016277:Ventricular Function, Left