title: Antibacterial activity of long-chain fatty alcohols against mycobacteria.
abstract: Tuberculosis is caused by the bacterium Mycobacterium tuberculosis and results in innumerable deaths across the world. The emergence of multidrug-resistant and extremely drug-resistant tuberculosis strains and its coinfection with HIV has made tuberculosis more difficult to treat. Therefore, new antimycobacterial agent(s) for both therapy and disinfection are urgently required. In this context the present study describes the antibacterial property of long-chain fatty alcohols against mycobacteria. The antimycobacterial activities of alcohols with chain length ranging from C(5) to C(13) were examined against Mycobacterium smegmatis mc(2) 155 and M. tuberculosis H(37)R(v). The best activity was found with one with a C(10) chain length. This bactericidal activity can partly be attributed to its ability to damage the robust and complex cell envelope of Mycobacteria. Moreover, our study reveals the ability of decanol to attenuate biofilm formation by M. smegmatis. This knowledge can be used to develop new therapeutics and disinfectants against mycobacteria.
authors.affiliation: Department of Microbiology, University of Calcutta, Kolkata, India.
authors.forename: Koushik
authors.initials: K
authors.lastname: Mukherjee
authors.forename: Prosun
authors.initials: P
authors.lastname: Tribedi
authors.forename: Balaram
authors.initials: B
authors.lastname: Mukhopadhyay
authors.forename: Alok Kumar
authors.initials: AK
authors.lastname: Sil
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D018441:Biofilms / Q000187:drug effects; D005233:Fatty Alcohols / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D009161:Mycobacterium / Q000187:drug effects*; D020102:Mycobacterium smegmatis / Q000187:drug effects; D009169:Mycobacterium tuberculosis / Q000187:drug effects; D013329:Structure-Activity Relationship
chemical_list: D000900:Anti-Bacterial Agents; D005233:Fatty Alcohols