title: A modern series of percutaneous intracavitary instillation of amphotericin B for the treatment of severe hemoptysis from pulmonary aspergilloma.
abstract: BACKGROUND
  Pulmonary aspergillomas may cause life-threatening hemoptysis. The treatment of this condition is problematic because poor pulmonary function often precludes definitive surgical resection.
  
  
  METHODS
  We retrospectively reviewed all patients hospitalized at our institution for hemoptysis associated with an aspergilloma over an 8-year period and who underwent percutaneous intracavitary instillation of amphotericin B (ICAB). ICAB consisted of catheter placement into the aspergilloma cavity with subsequent instillation of 50 mg amphotericin B in 20 mL 5% dextrose solution daily for 10 days.
  
  
  RESULTS
  ICAB was attempted for 23 distinct episodes of severe hemoptysis in 20 individual patients. Catheter placement was successful in 21 of the 23 episodes (91%), and of these, ICAB instillation was successfully completed in 20 episodes (95%). In these 20 episodes, hemoptysis ceased by hospital discharge in 17 of 20 patients (85%) and in all 18 who survived until a follow-up visit 1-month after treatment. Pneumothorax occurred in six of 23 (26%) catheter placement attempts without long-term complications. Recurrence of serious hemoptysis occurred after six of 18 episodes for which follow-up was available. Potential risk factors associated with severe, recurrent hemoptysis were a size increase or reappearance of the aspergilloma on a chest CT scan (P = .001), bleeding diathesis (P = .08), and lack of bronchial artery embolization during index hospitalization (P = .07).
  
  
  CONCLUSIONS
  Our data suggest that ICAB is an effective short-term treatment to control severe hemoptysis caused by pulmonary aspergilloma. The long-term benefit of this procedure is unknown. We identified several potential risk factors for recurrent hemoptysis after ICAB that could be examined prospectively in future trials.
authors.affiliation: Department of Medicine, University of Tennessee Medical Center, Knoxville, TN.
authors.forename: Jared N
authors.initials: JN
authors.lastname: Kravitz
authors.affiliation: Department of Radiology, Medical University of South Carolina, Charleston, SC.
authors.forename: Max W
authors.initials: MW
authors.lastname: Berry
authors.affiliation: Department of Radiology, Medical University of South Carolina, Charleston, SC.
authors.forename: Stephen I
authors.initials: SI
authors.lastname: Schabel
authors.affiliation: Division of Pulmonary and Critical Care Medicine, Albany Medical College, Albany, NY. Electronic address: judsonm@mail.amc.edu.
authors.forename: Marc A
authors.initials: MA
authors.lastname: Judson
mesh_terms: D000328:Adult; D000368:Aged; D000666:Amphotericin B / Q000008:administration & dosage / Q000627:therapeutic use*; D000935:Antifungal Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D001230:Aspergillus / Q000302:isolation & purification; D057785:Catheters; D005260:Female; D006469:Hemoptysis / Q000209:etiology*; D006801:Humans; D007322:Instillation, Drug; D008137:Longitudinal Studies; D008168:Lung / Q000382:microbiology; D008297:Male; D008875:Middle Aged; D055732:Pulmonary Aspergillosis / Q000150:complications* / Q000188:drug therapy*; D012189:Retrospective Studies; D012307:Risk Factors; D055502:Secondary Prevention; D012720:Severity of Illness Index; D016896:Treatment Outcome
chemical_list: D000935:Antifungal Agents; D000666:Amphotericin B