title: Enzyme-responsive controlled release of covalently bound prodrug from functional mesoporous silica nanospheres.
abstract: I want to break free: Mesoporous silica nanoparticles are functionalized with sulfasalazine (SZ; see scheme), a prodrug of 5-aminosalicylic acid (5-ASA) and sulfapyridine, to generate enzyme-responsive nanocarriers. In the presence of the colon-specific enzyme azo-reductase (orange), 5-ASA and sulfapyridine are efficiently released.
authors.affiliation: Australian Institute for Bioengineering and Nanotechnology, The University of Queensland, Brisbane, QLD 4072, Australia.
authors.forename: Amirali
authors.initials: A
authors.lastname: Popat
authors.forename: Benjamin P
authors.initials: BP
authors.lastname: Ross
authors.forename: Jian
authors.initials: J
authors.lastname: Liu
authors.forename: Siddharth
authors.initials: S
authors.lastname: Jambhrunkar
authors.forename: Freddy
authors.initials: F
authors.lastname: Kleitz
authors.forename: Shi Zhang
authors.initials: SZ
authors.lastname: Qiao
mesh_terms: D004337:Drug Carriers / Q000737:chemistry; D006863:Hydrogen-Ion Concentration; D019804:Mesalamine / Q000737:chemistry / Q000378:metabolism; D054118:Nanospheres / Q000737:chemistry*; D010088:Oxidoreductases / Q000378:metabolism*; D016062:Porosity; D011355:Prodrugs / Q000737:chemistry / Q000378:metabolism*; D012822:Silicon Dioxide / Q000737:chemistry*; D013427:Sulfapyridine / Q000737:chemistry / Q000378:metabolism; D012460:Sulfasalazine / Q000737:chemistry / Q000378:metabolism
chemical_list: D004337:Drug Carriers; D011355:Prodrugs; D012460:Sulfasalazine; D019804:Mesalamine; D012822:Silicon Dioxide; D010088:Oxidoreductases; D013427:Sulfapyridine