title: Involvement of membrane fluidity in endogenous protective processes running on subcellular membrane systems of the rat heart.
abstract: Membrane fluidity is a widely recognized biophysical variable that provides information about structural organization of the subcellular membranes exhibiting physical characteristics of liquid crystals. The term "fluidity" reflects in this case the tightness in packing of acyl parts of the membrane phospholipid molecules, a feature that may influence considerably the molecular mobility and via that also the sensitivity and reactivity of membrane-bound transporters, receptors and enzyme systems. Data presented in this review are aimed to demonstrate the substantial role of changes in membrane fluidity occurring in the processes associated with endogenous protection observed in cardiac sarcolemma and mitochondria in diverse pathologies, particularly in diabetes and hypertension.
authors.affiliation: Institute for Heart Research, Slovak Academy of Sciences and Centre of Excellence, Slovak Academy of Sciences, NO REG, Bratislava, Slovakia. usrdzigy@savba.sk
authors.forename: A
authors.initials: A
authors.lastname: Ziegelhöffer
authors.forename: I
authors.initials: I
authors.lastname: Waczulíková
authors.forename: M
authors.initials: M
authors.lastname: Ferko
authors.forename: L
authors.initials: L
authors.lastname: Šikurová
authors.forename: J
authors.initials: J
authors.lastname: Mujkošová
authors.forename: T
authors.initials: T
authors.lastname: Ravingerová
mesh_terms: D000818:Animals; D002462:Cell Membrane / Q000378:metabolism*; D008560:Membrane Fluidity / Q000502:physiology*; D008563:Membrane Lipids / Q000378:metabolism; D009206:Myocardium / Q000378:metabolism*; D010743:Phospholipids / Q000378:metabolism; D051381:Rats; D012508:Sarcolemma / Q000378:metabolism
chemical_list: D008563:Membrane Lipids; D010743:Phospholipids