title: Prognostic significance of 11q23 aberrations in adult acute myeloid leukemia and the role of allogeneic stem cell transplantation.
abstract: The clinical features and outcomes of 148 patients with acute myeloid leukemia (AML) and 11q23 chromosomal abnormalities were compared with those of 2640 patients with non-11q23 AML. Patients with t(9;11) ), t(6;11) or other 11q23 balanced translocations (t(11;v)(q23;v)) presented at a younger age and with higher percentage of bone marrow blasts. Unbalanced 11q23 abnormalities were commonly associated with deletions of chromosomes 5q, 7q and/or complex karyotypes. In multivariate analysis, when compared with patients with non-11q23 AML and unfavorable-risk karyotype, there was a significant difference in overall survival (OS) for patients with t(9;11) (P=0.004), whereas there were no differences in OS for patients with t(6;11) (P=0.62), t(11;19) (P=0.20) and unbalanced 11q23 aberrations (P=0.85) or t(11;v)(q23;v) (P=0.59), indicating that t(9;11) has an independent intermediate prognostic significance, with all others being poor prognostic factors for OS; this was further confirmed by comparing them with patients with non-11q23 AML and intermediate-risk karyotype. Using intention-to treat analysis based on donor availability, we also noted that allogeneic stem cell transplant in first remission had a significant benefit toward improving OS (P<0.001) and relapse-free survival (P<0.001) in patients with AML and 11q23 abnormalities.
authors.affiliation: Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
authors.forename: Y
authors.initials: Y
authors.lastname: Chen
authors.forename: H
authors.initials: H
authors.lastname: Kantarjian
authors.forename: S
authors.initials: S
authors.lastname: Pierce
authors.forename: S
authors.initials: S
authors.lastname: Faderl
authors.forename: S
authors.initials: S
authors.lastname: O'Brien
authors.forename: W
authors.initials: W
authors.lastname: Qiao
authors.forename: L
authors.initials: L
authors.lastname: Abruzzo
authors.forename: M
authors.initials: M
authors.lastname: de Lima
authors.forename: P
authors.initials: P
authors.lastname: Kebriaei
authors.forename: E
authors.initials: E
authors.lastname: Jabbour
authors.forename: N
authors.initials: N
authors.lastname: Daver
authors.forename: T
authors.initials: T
authors.lastname: Kadia
authors.forename: Z
authors.initials: Z
authors.lastname: Estrov
authors.forename: G
authors.initials: G
authors.lastname: Garcia-Manero
authors.forename: J
authors.initials: J
authors.lastname: Cortes
authors.forename: F
authors.initials: F
authors.lastname: Ravandi
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002880:Chromosomes, Human, Pair 11; D005260:Female; D006801:Humans; D007621:Karyotyping; D015470:Leukemia, Myeloid, Acute / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D012307:Risk Factors; D033581:Stem Cell Transplantation; D014178:Translocation, Genetic; D014184:Transplantation, Homologous; D055815:Young Adult