title: [The influence of COX-2 depressant in angiogenesis of oral squamous cell carcinoma].
abstract: OBJECTIVE
  To investigate the COX-2 depressant on cell apoptosis and angiogenesis of oral squamous cell carcinoma.
  
  
  METHODS
  RT-PCR and Western blotting were used to detect the effect of NS-398, the COX-2 inhibitor on mRNA and protein expression of VEGF and Survivin in oral squamous carcinoma cell line Tca8113. SPSS11.5 software package was used for statistical analysis.
  
  
  RESULTS
  NS-398 could down-regulate the expression of VEGF and Survivin in Tca8113 in a time-dependent manner.
  
  
  CONCLUSIONS
  NS-398 could down-regulate the expression of VEGF and survivin in Tca8113 and plays an important role in cell apoptosis and angiogenesis of oral squamous cell carcinoma.
authors.affiliation: Department of Stomatology, Liaoning Provincial People's Hospital, Shenyang 110016, China. xiaojusun@sina.com
authors.forename: Xiao-Ju
authors.initials: XJ
authors.lastname: Sun
authors.forename: Hong
authors.initials: H
authors.lastname: Xie
authors.forename: Xu-Kai
authors.initials: XK
authors.lastname: Wang
authors.forename: Hui
authors.initials: H
authors.lastname: Zhang
authors.forename: Cong-Xiao
authors.initials: CX
authors.lastname: Song
authors.forename: Yu-Jie
authors.initials: YJ
authors.lastname: Zhang
mesh_terms: D017209:Apoptosis; D002294:Carcinoma, Squamous Cell; D045744:Cell Line, Tumor; D051546:Cyclooxygenase 2; D015536:Down-Regulation; D006801:Humans; D009062:Mouth Neoplasms; D009578:Nitrobenzenes; D012333:RNA, Messenger; D013449:Sulfonamides
chemical_list: D009578:Nitrobenzenes; D012333:RNA, Messenger; D013449:Sulfonamides; C080955:N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide; D051546:Cyclooxygenase 2