title: Nutraceuticals as new treatment approaches for oral cancer--I: Curcumin.
abstract: Oral squamous cell carcinoma (OSCC) is a growing global public health problem for which standard therapeutic strategies have failed to contribute significantly to improve the survival rates that have remained around 50% over the past three decades. Therefore, there is a pressing need for new therapeutic strategies. Curcumin is a natural dietary compound with known anti-neoplastic activities, hence its classification as a nutraceutical agent. This review presents the current in vitro and in vivo studies in which curcumin has been examined for its anti-cancer potential in treating OSCC. Its mechanisms of action are also beginning to become unveiled. The available studies have been focusing on the impact of curcumin on epithelial malignant cells, but overlooking the components of the tumor microenvironment. Curcumin has been emerging as a promising therapeutic agent in oral cancer, either alone or in combination with standard therapeutic agents, and will probably become of practical use once its route of administration has overcome its poor bioavailability.
authors.affiliation: Department of Oral and Maxillofacial Surgery, Rabin Medical Center, Beilinson Campus, Petah Tikva, Israel.
authors.forename: Ayelet
authors.initials: A
authors.lastname: Zlotogorski
authors.forename: Aliza
authors.initials: A
authors.lastname: Dayan
authors.forename: Dan
authors.initials: D
authors.lastname: Dayan
authors.forename: Gavriel
authors.initials: G
authors.lastname: Chaushu
authors.forename: Tuula
authors.initials: T
authors.lastname: Salo
authors.forename: Marilena
authors.initials: M
authors.lastname: Vered
mesh_terms: D016588:Anticarcinogenic Agents / Q000627:therapeutic use; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D002294:Carcinoma, Squamous Cell / Q000188:drug therapy* / Q000473:pathology; D002471:Cell Transformation, Neoplastic / Q000187:drug effects; D003474:Curcumin / Q000627:therapeutic use*; D019587:Dietary Supplements; D004847:Epithelial Cells / Q000187:drug effects; D006801:Humans; D009062:Mouth Neoplasms / Q000188:drug therapy* / Q000473:pathology; D059016:Tumor Microenvironment / Q000187:drug effects
chemical_list: D016588:Anticarcinogenic Agents; D000970:Antineoplastic Agents; D003474:Curcumin