title: ZBTB38 gene polymorphism associated with body measurement traits in native Chinese cattle breeds.
abstract: Body measurement traits, influenced by genes and environmental factors, play numerous important roles in the value assessment of productivity and economy. In this study, we investigated the association between genetic polymorphisms of the zinc finger and BTB domain containing 38 gene (ZBTB38) and body measurement traits in native Chinese cattle. Using direct DNA sequencing in 423 individuals of 8 different cattle subpopulations, 9 novel polymorphisms were identified for genotyping within 647 bp region of exon 1 of ZBTB38. Linkage disequilibrium and association analysis revealed that two coding exon polymorphisms (2323 G>A and 2325 C>T polymorphisms), missense mutations valine GTC(T) to isoleucine ATC(T), were associated with body length (BL), withers height (WH) and rump length (RL). Furthermore, the analysis of 2323 G>A and 2325 C>T SNP markers shows that there are significant effects on the BL (P=0.0488), WH (P=0.0044) and RL (P=0.0314) in the total population. These results clearly suggest that the ZBTB38 gene is among the target genes for body measurement traits in bovine breeding, and provide data for establishment of an animal model using cattle to study big animal body type.
authors.affiliation: College of Food Engineering and Nutritional Science, Shaanxi Normal University, 710062, Xi'an, Shaanxi, PR China.
authors.forename: Yongfeng
authors.initials: Y
authors.lastname: Liu
authors.forename: Linsen
authors.initials: L
authors.lastname: Zan
authors.forename: Yaping
authors.initials: Y
authors.lastname: Xin
authors.forename: Wanqiang
authors.initials: W
authors.lastname: Tian
authors.forename: Linqiang
authors.initials: L
authors.lastname: Li
authors.forename: Hongcheng
authors.initials: H
authors.lastname: Wang
mesh_terms: D000818:Animals; D001837:Body Weights and Measures; D001947:Breeding; D002417:Cattle; D005091:Exons; D005260:Female; D006239:Haplotypes / Q000235:genetics; D015810:Linkage Disequilibrium; D008297:Male; D011110:Polymorphism, Genetic; D020641:Polymorphism, Single Nucleotide; D019655:Quantitative Trait, Heritable; D012097:Repressor Proteins / Q000235:genetics*; D016335:Zinc Fingers / Q000235:genetics
chemical_list: D012097:Repressor Proteins