title: Endothelial dysfunction and cardiac allograft vasculopathy.
abstract: Cardiac allograft vasculopathy remains a major challenge to long-term survival after heart transplantation. Endothelial injury and dysfunction, as a result of multifactorial immunologic and nonimmunologic insults in the donor and the recipient, are prevalent early after transplant and may be precursors to overt cardiac allograft vasculopathy. Current strategies for managing cardiac allograft vasculopathy, however, rely on the identification and treatment of established disease. Improved understanding of mechanisms leading to endothelial dysfunction in heart transplant recipients may provide the foundation for the development of sensitive screening techniques and preventive therapies.
authors.affiliation: Cardiovascular Division, University of Minnesota, Minneapolis, MN 55455, USA. Colvi005@umn.edu
authors.forename: Monica
authors.initials: M
authors.lastname: Colvin-Adams
authors.forename: Nonyelum
authors.initials: N
authors.lastname: Harcourt
authors.forename: Daniel
authors.initials: D
authors.lastname: Duprez
mesh_terms: D000818:Animals; D003324:Coronary Artery Disease / Q000175:diagnosis / Q000209:etiology* / Q000503:physiopathology / Q000628:therapy; D003331:Coronary Vessels / Q000293:injuries / Q000503:physiopathology*; D004730:Endothelium, Vascular / Q000293:injuries / Q000503:physiopathology*; D006085:Graft Survival; D016027:Heart Transplantation / Q000009:adverse effects*; D006801:Humans; D016896:Treatment Outcome; D057772:Vascular System Injuries / Q000175:diagnosis / Q000209:etiology* / Q000503:physiopathology / Q000628:therapy