title: Classifying odontogenic keratocysts as benign cystic neoplasms: a molecular insight into its aggressiveness.
abstract: OBJECTIVE
  The present study was conducted with the aim to evaluate the expression of p53 in Odontogenic Keratocyst (OKC) and Ameloblastoma to correlate with the aggressiveness of these lesions.
  
  
  METHODS
  Immunohistochemical (IHC) staining was performed using anti-p53 antibody in eighteen cases each of OKC and ameloblastoma.
  
  
  RESULTS
  p53 positivity was seen in all the cases of OKCs and ameloblastomas. p53 positive cells were seen predominantly in the suprabasal cell layer of OKC and in the peripheral pre-ameloblast like cells in ameloblastoma. Total p53 count was significantly higher in ameloblastoma as compared to OKC. But the intensely stained p53 cell count showed no statistically significant difference between the two lesions.
  
  
  CONCLUSIONS
  The high p53 expression in OKC when compared with ameloblastoma, acknowledges OKC as an aggressive lesion and hence a more aggressive treatment modality is recommended.
authors.affiliation: Dept. of Oral and Maxillofacial Pathology and Microbiology, I.T.S.-CDSR, Ghaziabad, India  ; I.T.S Center for Dental Studies & Research, Delhi-Meerut Road, Murad Nagar Ghaziabad, Uttar Pradesh, India.
authors.forename: Devi Charan
authors.initials: DC
authors.lastname: Shetty
authors.forename: Aadithya B
authors.initials: AB
authors.lastname: Urs
authors.forename: Suhas
authors.initials: S
authors.lastname: Godhi
authors.forename: Sandeep
authors.initials: S
authors.lastname: Gupta
keywords: Aggressiveness; Ameloblastoma; Intensity; Odontogenic keratocyst; p53