title: The association of Klotho polymorphism with disease progression and mortality in IgA nephropathy.
abstract: BACKGROUND
  IgA nephropathy (IgAN) is the most common primary glomerulonephritis causing end stage renal disease (ESRD), and vasculopathy is known to involve disease progression. Klotho, a gene related to aging, has been reported to play a role in atherosclerosis and endothelial dysfunction. We investigated whether klotho gene polymorphism affect clinical course of IgAN.
  
  
  METHODS
  The data registered for PREMIER study which enrolled the patients with biopsy proven IgAN were analyzed. Two single nucleotide polymorphisms for klotho gene, G395A of promoter region and C1818T of exon 4, were examined, and investigated the association klotho genotypes with the progression of IgAN and patient survival.
  
  
  RESULTS
  Clinical data from 973 patients confirmed about survival were analyzed. The allele frequency was 0.830 and 0.170 for allele G and A, and 0.816 and 0.184 for allele C and T, which were complied with Hardy-Weinberg equilibrium (p=0.996 and 0.531 respectively). Death was observed more frequently in A-allele carriers of G395A polymorphism (0.7 vs. 2.6 %, GG vs. GA+AA, p=0.022). Renal survival in Kaplan-Meier survival curve was also worse in same group (p=0.04).
  
  
  CONCLUSIONS
  Klotho gene polymorphism was associated with patient survival and disease progression of IgAN.
authors.affiliation: Korea University Medical school, Department of Internal Medicine, Seoul, Korea.
authors.forename: Gang Jee
authors.initials: GJ
authors.lastname: Ko
authors.forename: Eun Ah
authors.initials: EA
authors.lastname: Lee
authors.forename: Un Sil
authors.initials: US
authors.lastname: Jeon
authors.forename: Heui Jung
authors.initials: HJ
authors.lastname: Pyo
authors.forename: Ho Jun
authors.initials: HJ
authors.lastname: Chin
authors.forename: Dong Wan
authors.initials: DW
authors.lastname: Chae
authors.forename: Suhnggwon
authors.initials: S
authors.lastname: Kim
authors.forename: Young Joo
authors.initials: YJ
authors.lastname: Kwon
mesh_terms: D000328:Adult; D018450:Disease Progression; D005091:Exons / Q000235:genetics; D005260:Female; D005787:Gene Frequency / Q000235:genetics; D005838:Genotype; D005922:Glomerulonephritis, IGA / Q000208:ethnology / Q000235:genetics* / Q000401:mortality*; D005966:Glucuronidase / Q000235:genetics*; D006801:Humans; D053208:Kaplan-Meier Estimate; D000090265:Klotho Proteins; D007723:Korea; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D015996:Survival Rate
chemical_list: D005966:Glucuronidase; D000090265:Klotho Proteins