title: Decreased default network connectivity is associated with early life stress in medication-free healthy adults.
abstract: Early life stress (ELS) is a significant risk factor for psychopathology, although there are few functional imaging studies investigating its effects. Previous literature suggests that ELS is associated with changes in structure and function in the medial prefrontal cortex (MPFC), which forms the main anterior node of the default network (DN). This study investigated the impact of ELS history on resting state DN connectivity, using seed-based correlation analyses (SCA) involving the posterior cingulate cortex (PCC). Data were analyzed from 22 adult subjects without psychiatric or medical illness (13 with and 9 without ELS); none were taking psychotropic medication. Relative to controls, the ELS group had significant decreases in DN connectivity, observed between the PCC seed and the MPFC and inferior temporal cortex. Further analyses revealed a trend-level increase in connectivity between the amygdala and MPFC associated with ELS history. In conclusion, this study found that subjects with ELS, in the absence of psychiatric illness and medication exposure, demonstrated decreased DN connectivity, and trend-level increases in connectivity between the amygdala and MPFC. These findings suggest that altered resting state connectivity is a correlate of stress exposure, rather than a product of medication or psychiatric morbidity.
authors.affiliation: Laboratory for Clinical and Translational Neuroscience, Butler Hospital, Department of Psychiatry and Human Behavior, Alpert Medical School of Brown University, Providence, RI 02906, USA. Noah_Philip@Brown.edu
authors.forename: Noah S
authors.initials: NS
authors.lastname: Philip
authors.forename: Lawrence H
authors.initials: LH
authors.lastname: Sweet
authors.forename: Audrey R
authors.initials: AR
authors.lastname: Tyrka
authors.forename: Lawrence H
authors.initials: LH
authors.lastname: Price
authors.forename: Rachel F
authors.initials: RF
authors.lastname: Bloom
authors.forename: Linda L
authors.initials: LL
authors.lastname: Carpenter
mesh_terms: D000293:Adolescent; D041923:Adolescent Development; D000328:Adult; D000679:Amygdala / Q000378:metabolism / Q000473:pathology; D002648:Child; D002657:Child Development; D039721:Diagnostic and Statistical Manual of Mental Disorders; D005260:Female; D006179:Gyrus Cinguli / Q000378:metabolism* / Q000473:pathology; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D009415:Nerve Net / Q000378:metabolism* / Q000473:pathology; D009434:Neural Pathways; D010865:Pilot Projects; D017397:Prefrontal Cortex / Q000378:metabolism* / Q000473:pathology; D055500:Resilience, Psychological; D013313:Stress Disorders, Post-Traumatic / Q000378:metabolism* / Q000473:pathology / Q000523:psychology; D013315:Stress, Psychological / Q000378:metabolism / Q000473:pathology / Q000523:psychology; D013702:Temporal Lobe / Q000378:metabolism* / Q000473:pathology