title: [Per os given bacteriophages changes the clinical course of diseases caused by bacterial agents in children].
abstract: The aim of the study was to reveal the possible effect of perorally given bacteriophages on the clinical course of diseases caused by infectious agents in children.   The complex therapy with inclusion of bacteriophages was performed in 85 children aged from 1 week to 15 years, 36 girls, 47 boys with following diagnoses: sepsis, bacterial diarrhea, urinary tract infections, bacterial infections of upper respiratory ways, bacterial pneumonia. For every case an appropriate analoguous control was matched. Thus this open clinical trial was carried out according to the Case Control Study design. Clinical and paraclinical markers specific for different diseases and integrated index of the gravitidy of condition. defined by the method of multicriterial analyzis with usage of Fuzzy logic approaches were revealed in dynamics.   It was established that by peroral treatment with commercial bacteriophages the positive trends of investigated parameters had place. The improvement of the integrated index of gravitidy was most pronounced. We suppose that obtaining of more convincing evidences of the clinical value of bacteriophagetherapy the further studies in the more number of patients with the usage of the generally accepted double blind method should be conducted.
authors.forename: K I
authors.initials: KI
authors.lastname: Pagava
authors.forename: G J
authors.initials: GJ
authors.lastname: Metskhvarishvili
authors.forename: I A
authors.initials: IA
authors.lastname: Korineli
authors.forename: T B
authors.initials: TB
authors.lastname: Gongadze
mesh_terms: D000284:Administration, Oral; D000293:Adolescent; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000737:chemistry; D001435:Bacteriophages / Q000737:chemistry*; D002648:Child; D002675:Child, Preschool; D003967:Diarrhea / Q000188:drug therapy* / Q000382:microbiology / Q000473:pathology; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D011014:Pneumonia / Q000188:drug therapy* / Q000382:microbiology / Q000473:pathology; D018805:Sepsis / Q000188:drug therapy* / Q000382:microbiology / Q000473:pathology; D014552:Urinary Tract Infections / Q000188:drug therapy* / Q000382:microbiology / Q000473:pathology
chemical_list: D000900:Anti-Bacterial Agents