title: Adjunct therapy of Ayurvedic medicine with anti tubercular drugs on the therapeutic management of pulmonary tuberculosis.
abstract: BACKGROUND
  Pulmonary tuberculosis (PTB) is an age old disease described in Vedic Medicine as 'Yakshma'. Later on, in Ayurveda it earned a prefix and found way into mythology as 'Rajayakshma'. After the discovery of streptomycin, the therapeutic management of PTB received a major breakthrough. The treatment module changed remarkably with the formulation of newer anti-tubercular drugs (ATD) with appreciable success. Recent resurgence of PTB in developed countries like United States posed a threat to the medical community due to resistant strains. Consequently, WHO looked toward traditional medicine. Literature reveals that Ayurvedic treatment of PTB was in vogue in India before the introduction of ATD with limited success. Records show that 2766 patients of PTB were treated with Ayurvedic drugs in a tertiary care hospital in Kolkata in the year 1933-1947.
  
  
  OBJECTIVE
  To evaluate the toxicity reduction and early restoration by adjunct therapy of Ayurvedic drugs by increasing the bio-availability of ATDs.
  
  
  METHODS
  In the present study, treatment response of 99 patients treated with ATD as an adjunct with Aswagandha (Withania somnifera) and a multi-herbal formulation described in Chikitsa-sthana of Charaka samhita i.e. Chyawanprash were investigated. Hematological profile, sputum bacterial load count, immunoglobulin IgA and IgM, blood sugar, liver function test, serum creatinine were the assessed parameters besides blood isoniazid and pyrazinamide, repeated after 28 days of treatment.
  
  
  RESULTS
  The symptoms abated, body weight showed improvement, ESR values were normal, there was appreciable change in IgA and IgM patterns and significantly increased bioavailability of isoniazid and pyrazinamide were recorded.
  
  
  CONCLUSIONS
  This innovative clinical study coupled with empowered research may turn out to be promising in finding a solution for the treatment of PTB.
authors.affiliation: National Research Institute of Ayurvedic Drug Development, Kolkata, India .
authors.forename: P K
authors.initials: PK
authors.lastname: Debnath
authors.forename: Jaydeb
authors.initials: J
authors.lastname: Chattopadhyay
authors.forename: Achintya
authors.initials: A
authors.lastname: Mitra
authors.forename: Anjan
authors.initials: A
authors.lastname: Adhikari
authors.forename: Mirza Samsur
authors.initials: MS
authors.lastname: Alam
authors.forename: S K
authors.initials: SK
authors.lastname: Bandopadhyay
authors.forename: Jayram
authors.initials: J
authors.lastname: Hazra
keywords: Adjunct therapy; Ayurveda; anti-tubercular drugs; tuberculosis