title: Cord blood oxidative stress markers correlate with umbilical artery pulsatility in fetal growth restriction.
abstract: OBJECTIVE
  To compare cord blood oxidative stress markers (OSM) between intrauterine small fetuses with high umbilical artery (UA) Doppler indices and normal indices.
  
  
  METHODS
  Forty women who had oligohydramnios and intrauterine growth-restricted fetuses with abnormal (n = 20, group I) or normal Doppler indices (n = 20, group II) were included. All patients underwent fetal Doppler ultrasound studies. Cord blood was collected at birth and six OSMs (ischemia-modified albumin (IMA), hepatocyte growth factor (HGF), malondialdehyde (MDA)) levels, total oxidant status (TOS), total antioxidant status (TAS), and oxidative stress index (OSI) were studied.
  
  
  RESULTS
  The mean cord blood IMA, MDA, TOS, and OSI values for group I were significantly increased when compared to the group II (p < 0.001 for IMA, MDA, TOS, and OSI). However the mean cord blood HGF and TAS values were statistically significantly decreased in group I, compared with group II (p < 0.001 for HGF, and TAS). A significant positive (for IMA, MDA,TOS levels, and OSI ratio) and negative (for HGF and TAS levels) correlations between UA pulsatility index (PI) and cord blood OSM were found.
  
  
  CONCLUSIONS
  The correlation between cord blood OSM and Doppler blood flow changes shown in this study may contribute to understanding the underlying oxidative stress-related mechanisms.
authors.affiliation: Recep Tayyip Erdogan University, School of Medicine, Department of Obstetrics and Gynecology, Rize, Turkey. emineseda@yahoo.com
authors.forename: Emine Seda
authors.initials: ES
authors.lastname: Guvendag Guven
authors.forename: Deniz
authors.initials: D
authors.lastname: Karcaaltincaba
authors.forename: Omer
authors.initials: O
authors.lastname: Kandemir
authors.forename: Sadiman
authors.initials: S
authors.lastname: Kiykac
authors.forename: Ahmet
authors.initials: A
authors.lastname: Mentese
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000097:blood*; D005260:Female; D005312:Fetal Blood / Q000378:metabolism; D005317:Fetal Growth Retardation / Q000097:blood* / Q000000981:diagnostic imaging* / Q000503:physiopathology; D006801:Humans; D018384:Oxidative Stress; D011247:Pregnancy; D011673:Pulsatile Flow; D018617:Ultrasonography, Doppler, Pulsed; D016216:Ultrasonography, Prenatal; D014469:Umbilical Arteries / Q000000981:diagnostic imaging* / Q000503:physiopathology; D055815:Young Adult
chemical_list: D015415:Biomarkers