title: A novel small molecule facilitates the reprogramming of human somatic cells into a pluripotent state and supports the maintenance of an undifferentiated state of human pluripotent stem cells.
abstract: Booster of pluripotency: RSC133, a new synthetic derivative of indoleacrylic acid/indolepropionic acid, exhibits dual activity by inhibiting histone deacetylase and DNA methyltransferase. Furthermore it potently improves the reprogramming of human somatic cells into a pluripotent state and aids the growth and maintenance of human pluripotent stem cells (hPSCs).
authors.affiliation: Regenerative Medicine Research Center, Korea Research Institute of Bioscience and Biotechnology, 125 Gwahak-ro, Yuseong-gu, Daejeon 305-806, S. Korea.
authors.forename: Jungwoon
authors.initials: J
authors.lastname: Lee
authors.forename: Yan
authors.initials: Y
authors.lastname: Xia
authors.forename: Mi-Young
authors.initials: MY
authors.lastname: Son
authors.forename: Guanghai
authors.initials: G
authors.lastname: Jin
authors.forename: Binna
authors.initials: B
authors.lastname: Seol
authors.forename: Min-Jeong
authors.initials: MJ
authors.lastname: Kim
authors.forename: Myung Jin
authors.initials: MJ
authors.lastname: Son
authors.forename: Misol
authors.initials: M
authors.lastname: Do
authors.forename: Minho
authors.initials: M
authors.lastname: Lee
authors.forename: Dongsup
authors.initials: D
authors.lastname: Kim
authors.forename: Kyeong
authors.initials: K
authors.lastname: Lee
authors.forename: Yee Sook
authors.initials: YS
authors.lastname: Cho
mesh_terms: D000818:Animals; D002454:Cell Differentiation / Q000187:drug effects; D002460:Cell Line; D049109:Cell Proliferation / Q000187:drug effects; D065150:Cellular Reprogramming / Q000187:drug effects; D004248:DNA (Cytosine-5-)-Methyltransferases / Q000037:antagonists & inhibitors / Q000378:metabolism; D006655:Histone Deacetylases / Q000737:chemistry / Q000378:metabolism; D006801:Humans; D007211:Indoles / Q000737:chemistry / Q000494:pharmacology*; D051379:Mice; D039904:Pluripotent Stem Cells / Q000166:cytology* / Q000201:enzymology / Q000378:metabolism; D014157:Transcription Factors / Q000378:metabolism
chemical_list: D007211:Indoles; C581186:RSC133; D014157:Transcription Factors; C015292:indolepropionic acid; C001446:indoleacrylic acid; D004248:DNA (Cytosine-5-)-Methyltransferases; D006655:Histone Deacetylases