title: β-Site amyloid precursor protein-cleaving enzyme 1 activity is related to cerebrospinal fluid concentrations of sortilin-related receptor with A-type repeats, soluble amyloid precursor protein, and tau.
abstract: BACKGROUND
  β-Site amyloid precursor protein (APP)-cleaving enzyme 1 (BACE1) activity determines the rate of APP cleavage and is therefore the main driver of amyloid β production, which is a pathological hallmark of Alzheimer's disease (AD).
  
  
  METHODS
  The present study explored the correlation between BACE1 activity and cerebrospinal fluid (CSF) markers of APP metabolism and axonal degeneration in 63 patients with mild AD and 12 healthy control subjects.
  
  
  RESULTS
  In the AD group, positive correlations between BACE1 activity and soluble APP β, the APP sorting receptor sortilin-related receptor with A-type repeats (also known as SorLA or LR11), and tau were detected. BACE1 activity was not associated with amyloid β1-42 or soluble APP α concentrations in the AD group, and no associations between BACE1 activity and any of the protein concentrations were found in the control group.
  
  
  CONCLUSIONS
  Our results confirm the relevance of BACE1 and sortilin-related receptor with A-type repeats within the amyloid cascade and also provide a further piece of evidence for the link between amyloid and tau pathology in AD.
authors.affiliation: Department of Psychiatry and Psychotherapy, Klinikum rechts der Isar, Technische Universität München, München, Germany.
authors.forename: Amalia
authors.initials: A
authors.lastname: Tsolakidou
authors.forename: Panagiotis
authors.initials: P
authors.lastname: Alexopoulos
authors.forename: Liang-Hao
authors.initials: LH
authors.lastname: Guo
authors.forename: Timo
authors.initials: T
authors.lastname: Grimmer
authors.forename: Christine
authors.initials: C
authors.lastname: Westerteicher
authors.forename: Martina
authors.initials: M
authors.lastname: Kratzer
authors.forename: Meizi
authors.initials: M
authors.lastname: Jiang
authors.forename: Hideaki
authors.initials: H
authors.lastname: Bujo
authors.forename: Francesco
authors.initials: F
authors.lastname: Roselli
authors.forename: Maria Rosaria
authors.initials: MR
authors.lastname: Leante
authors.forename: Paolo
authors.initials: P
authors.lastname: Livrea
authors.forename: Alexander
authors.initials: A
authors.lastname: Kurz
authors.forename: Robert
authors.initials: R
authors.lastname: Perneczky
mesh_terms: D000328:Adult; D000368:Aged; D000544:Alzheimer Disease / Q000134:cerebrospinal fluid*; D053829:Amyloid Precursor Protein Secretases / Q000134:cerebrospinal fluid*; D016229:Amyloid beta-Peptides / Q000134:cerebrospinal fluid; D016564:Amyloid beta-Protein Precursor / Q000134:cerebrospinal fluid / Q000378:metabolism; D016282:Aspartic Acid Endopeptidases / Q000134:cerebrospinal fluid*; D015415:Biomarkers; D005260:Female; D006801:Humans; D026502:LDL-Receptor Related Proteins / Q000134:cerebrospinal fluid*; D008297:Male; D026901:Membrane Transport Proteins / Q000134:cerebrospinal fluid*; D008875:Middle Aged; D010446:Peptide Fragments / Q000134:cerebrospinal fluid; D011594:Psychometrics; D012183:Retrograde Degeneration; D016875:tau Proteins / Q000134:cerebrospinal fluid*
chemical_list: D016229:Amyloid beta-Peptides; D016564:Amyloid beta-Protein Precursor; D015415:Biomarkers; D026502:LDL-Receptor Related Proteins; C054369:MAPT protein, human; D026901:Membrane Transport Proteins; D010446:Peptide Fragments; C102582:SORL1 protein, human; C075222:amyloid beta-protein (1-42); D016875:tau Proteins; D053829:Amyloid Precursor Protein Secretases; D016282:Aspartic Acid Endopeptidases; C509280:BACE1 protein, human