title: Adipose tissue inflammation in diabetes and heart failure.
abstract: Adipose tissue inflammation induces systemic insulin resistance in persons with obesity and heart failure, and has a crucial role in the progression of these diseases. Chronic inflammatory processes share a common mechanism in which increased production of reactive oxygen species activates p53 and NF-κB signaling, leading to up-regulation of pro-inflammatory cytokine expression and impairment of glucose metabolism. Since inhibition of these processes could slow the progression of various diseases, targeting adipose inflammation has the potential to become a new therapeutic approach for diabetes and heart failure.
authors.affiliation: Department of Cardiovascular Science and Medicine, Chiba University Graduate School of Medicine, Chiba 260-8670, Japan.
authors.forename: Ippei
authors.initials: I
authors.lastname: Shimizu
authors.forename: Yohko
authors.initials: Y
authors.lastname: Yoshida
authors.forename: Taro
authors.initials: T
authors.lastname: Katsuno
authors.forename: Tohru
authors.initials: T
authors.lastname: Minamino
mesh_terms: D000273:Adipose Tissue / Q000473:pathology*; D000818:Animals; D003920:Diabetes Mellitus / Q000473:pathology*; D006333:Heart Failure / Q000473:pathology*; D006801:Humans; D007249:Inflammation / Q000473:pathology*