title: Schistosoma mansoni infection in preschool-aged children: development of immunoglobulin E and immunoglobulin G4 responses to parasite allergen-like proteins.
abstract: Specific immunoglobulin E (IgE) responses are upregulated during chronic schistosome infection and during allergy. These responses are tightly regulated during schistosomiasis. We have previously shown that IgE regulation depends on the extent and length of exposure to individual parasite allergen-like proteins. Here we compare the development of IgE and immunoglobulin G4 (IgG(4)) responses to the differentially expressed allergen-like proteins SmTAL1 and SmTAL2 among preschool-aged children from 2 villages with different levels of Schistosoma mansoni transmission. We found a lack of SmTAL1 responsiveness among all children, but evidence for IgG(4)-dependent IgE-SmTAL2 desensitization in both villages, occurring earlier among children from the village where the level of transmission was greater. Findings provide insights into the development and regulation of allergic-type immune responses.
authors.affiliation: Department of Pathology, University of Cambridge, United Kingdom. acp44@cam.ac.uk
authors.forename: Angela
authors.initials: A
authors.lastname: Pinot de Moira
authors.forename: Jose C
authors.initials: JC
authors.lastname: Sousa-Figueiredo
authors.forename: Frances M
authors.initials: FM
authors.lastname: Jones
authors.forename: Colin M
authors.initials: CM
authors.lastname: Fitzsimmons
authors.forename: Martha
authors.initials: M
authors.lastname: Betson
authors.forename: Narcis B
authors.initials: NB
authors.lastname: Kabatereine
authors.forename: J Russell
authors.initials: JR
authors.lastname: Stothard
authors.forename: David W
authors.initials: DW
authors.lastname: Dunne
mesh_terms: D000328:Adult; D000485:Allergens / Q000276:immunology*; D000818:Animals; D002675:Child, Preschool; D005260:Female; D015801:Helminth Proteins / Q000276:immunology*; D006801:Humans; D007073:Immunoglobulin E / Q000097:blood*; D007074:Immunoglobulin G / Q000097:blood*; D007223:Infant; D012550:Schistosoma mansoni / Q000276:immunology*; D012555:Schistosomiasis mansoni / Q000276:immunology* / Q000469:parasitology / Q000635:transmission; D014454:Uganda
chemical_list: D000485:Allergens; D015801:Helminth Proteins; D007074:Immunoglobulin G; D007073:Immunoglobulin E