title: Brominated aromatic furanones and related esters from the ascidian Synoicum sp.
abstract: Nine new compounds, tris-aromatic furanones (1, 2, 3a, 3b, and 4) and related bis-aromatic diesters (5a, 5b, 6a, and 6b), are described from the ascidian Synoicum sp. collected off the coast of Chuja-do, Korea. The structures of these compounds, designated as cadiolides E and G-I (1-4) and synoilides A and B (5 and 6), were determined by extensive spectroscopic analyses. The absolute configuration at the asymmetric center of cadiolide G (2) was assigned by ECD analysis. Of these new compounds, cadiolide I and the synoilides possess unprecedented carbon skeletons. Several of these compounds exhibited significant inhibition against diverse bacterial strains as well as moderate inhibition against the enzymes sortase A, isocitrate lyase, and Na(+)/K(+)-ATPase.
authors.affiliation: Natural Products Research Institute, College of Pharmacy,  Seoul National University , San 56-1, Sillim, Gwanak, Seoul 151-742, Korea.
authors.forename: Tae Hyung
authors.initials: TH
authors.lastname: Won
authors.forename: Ju-eun
authors.initials: JE
authors.lastname: Jeon
authors.forename: Seong-Hwan
authors.initials: SH
authors.lastname: Kim
authors.forename: So-Hyoung
authors.initials: SH
authors.lastname: Lee
authors.forename: Boon Jo
authors.initials: BJ
authors.lastname: Rho
authors.forename: Dong-Chan
authors.initials: DC
authors.lastname: Oh
authors.forename: Ki-Bong
authors.initials: KB
authors.lastname: Oh
authors.forename: Jongheon
authors.initials: J
authors.lastname: Shin
mesh_terms: D019881:Aminoacyltransferases / Q000037:antagonists & inhibitors; D000818:Animals; D001426:Bacterial Proteins / Q000037:antagonists & inhibitors; D003546:Cysteine Endopeptidases; D004354:Drug Screening Assays, Antitumor; D004952:Esters; D005663:Furans / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D006842:Hydrocarbons, Brominated / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D007522:Isocitrate Lyase / Q000037:antagonists & inhibitors; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D056910:Republic of Korea; D000254:Sodium-Potassium-Exchanging ATPase / Q000037:antagonists & inhibitors; D013211:Staphylococcus aureus / Q000187:drug effects; D014561:Urochordata / Q000737:chemistry
chemical_list: D001426:Bacterial Proteins; D004952:Esters; D005663:Furans; D006842:Hydrocarbons, Brominated; D019881:Aminoacyltransferases; C120542:sortase A; D003546:Cysteine Endopeptidases; D007522:Isocitrate Lyase; D000254:Sodium-Potassium-Exchanging ATPase