title: Restoring totipotency through epigenetic reprogramming.
abstract: Epigenetic modifications are implicated in the maintenance and regulation of transcriptional memory by marking genes that were previously transcribed to facilitate transmission of these expression patterns through cell division. During germline specification and maintenance, extensive epigenetic modifications are acquired. Yet somehow at fertilization, the fusion of the highly differentiated sperm and egg results in formation of the totipotent zygote. This massive change in cell fate implies that the selective erasure and maintenance of epigenetic modifications at fertilization may be critical for the re-establishment of totipotency. In this review, we discuss recent studies that provide insight into the extensive epigenetic reprogramming that occurs around fertilization and the mechanisms that may be involved in the re-establishment of totipotency in the embryo.
authors.affiliation: Department of Cell Biology, Emory University, Atlanta, GA 30322, USA.
authors.forename: Jadiel A
authors.initials: JA
authors.lastname: Wasson
authors.forename: Chelsey C
authors.initials: CC
authors.lastname: Ruppersburg
authors.forename: David J
authors.initials: DJ
authors.lastname: Katz
mesh_terms: D000818:Animals; D065150:Cellular Reprogramming / Q000235:genetics*; D019175:DNA Methylation / Q000235:genetics; D044127:Epigenesis, Genetic; D005306:Fertilization / Q000235:genetics; D006801:Humans; D040582:Inheritance Patterns / Q000235:genetics; D039901:Totipotent Stem Cells / Q000378:metabolism*