title: Impact of retrotransposons in pluripotent stem cells.
abstract: Retrotransposons, which constitute approximately 40% of the human genome, have the capacity to 'jump' across the genome. Their mobility contributes to oncogenesis, evolution, and genomic plasticity of the host genome. Induced pluripotent stem cells as well as embryonic stem cells are more susceptible than differentiated cells to genomic aberrations including insertion, deletion and duplication. Recent studies have revealed specific behaviors of retrotransposons in pluripotent cells. Here, we review recent progress in understanding retrotransposons and provide a perspective on the relationship between retrotransposons and genomic variation in pluripotent stem cells.
authors.affiliation: Department of Genetics, Yale Stem Cell Center, Yale School of Medicine, 10 Amistad, 201B, New Haven, CT 06520, USA.
authors.forename: Yoshiaki
authors.initials: Y
authors.lastname: Tanaka
authors.forename: Leeyup
authors.initials: L
authors.lastname: Chung
authors.forename: In-Hyun
authors.initials: IH
authors.lastname: Park
mesh_terms: D020087:Alu Elements; D002454:Cell Differentiation; D053595:Embryonic Stem Cells / Q000378:metabolism; D015894:Genome, Human; D006801:Humans; D057026:Induced Pluripotent Stem Cells / Q000378:metabolism; D039904:Pluripotent Stem Cells / Q000378:metabolism*; D018626:Retroelements
chemical_list: D018626:Retroelements