title: Mycophenolate mofetil and tacrolimus reduce mortality after deceased donor kidney transplantation.
abstract: A study of mortality in renal transplantation recipients showed that the combination of mycophenolate mofetil (MMF) and tacrolimus (TaC) reduced the mortality rate. We studied 1045 consecutive adult deceased donor kidney transplant recipients from 1986-2001, where follow-up to 2011 was a minimum of 10 years, to analyze the impact of these immunosuppressive drugs on patient survival. Cox multivariate analysis showed that treatment with MMF and the use of TaC instead of cyclosporine reduced the risk of death by 43%. In conclusion, both immunosuppressive drugs reduced the risk of death of patients receiving from renal transplants deceased donors.
authors.affiliation: Nephrology Department, Carlos Haya University Hospital, Malaga and Torrecardenas Hospital, Almeria, Spain. mgonmol@yahoo.es
authors.forename: M
authors.initials: M
authors.lastname: Gonzalez-Molina
authors.forename: P
authors.initials: P
authors.lastname: Ruiz-Esteban
authors.forename: D
authors.initials: D
authors.lastname: Burgos
authors.forename: M A
authors.initials: MA
authors.lastname: Rodriguez
authors.forename: M
authors.initials: M
authors.lastname: Cabello
authors.forename: E
authors.initials: E
authors.lastname: Gutierrez
authors.forename: D
authors.initials: D
authors.lastname: Hernandez
mesh_terms: D000328:Adult; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects*; D053208:Kaplan-Meier Estimate; D016030:Kidney Transplantation / Q000009:adverse effects / Q000401:mortality*; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D009173:Mycophenolic Acid / Q000031:analogs & derivatives* / Q000627:therapeutic use; D016016:Proportional Hazards Models; D012189:Retrospective Studies; D018570:Risk Assessment; D012307:Risk Factors; D015996:Survival Rate; D016559:Tacrolimus / Q000627:therapeutic use*; D013997:Time Factors; D014019:Tissue Donors / Q000600:supply & distribution*; D009927:Tissue and Organ Procurement; D016896:Treatment Outcome
chemical_list: D007166:Immunosuppressive Agents; D009173:Mycophenolic Acid; D016559:Tacrolimus