title: Synchronous penile metastasis from a high-grade adenocarcinoma of the prostate.
abstract: Metastasis to the glans penis is a rare phenomenon and usually occurs in a late stage of disease. A 68-year-old man was referred to our clinic because of two indurated lesions of the glans penis and minor lower urinary tract symptoms. Digital rectal examination revealed a hard nodular prostate, and serum prostate-specific antigen (sPSA) level was 13.3 ng/mL. Biopsies of the penile lesions and transrectal ultrasound-guided prostate biopsies were taken. Immunohistochemical staining of formalin-fixed paraffin-embedded tissue exposed a synchronous penile metastasis from a high-grade adenocarcinoma of the prostate. Except a pathologically enlarged lymph node detected with MRI there was no suspicion on other metastases. Currently this patient is being treated with a Gonadoreline (GnRH) antagonist. Nevertheless, the prognosis will be poor.
authors.affiliation: Department of Urology, Radboud University Nijmegen Medical Centre, Geert Grooteplein Zuid 10, P.O. Box 9101, 6500 HB Nijmegen, The Netherlands.
authors.forename: S
authors.initials: S
authors.lastname: Dijkstra
authors.forename: A G
authors.initials: AG
authors.lastname: van der Heijden
authors.forename: H E
authors.initials: HE
authors.lastname: Schaafsma
authors.forename: P F A
authors.initials: PF
authors.lastname: Mulders