title: EDIM-TKTL1 blood test: a noninvasive method to detect upregulated glucose metabolism in patients with malignancies.
abstract: OBJECTIVE
  To determine whether the TKTL1 protein epitope detection in monocytes (EDIM) test allows detection of upregulated glucose metabolism in malignancies.
  
  
  METHODS
  The EDIM-TKTL1 blood test was conducted in 240 patients with 17 different confirmed or suspected malignancies. Test scores were compared with (18)F-fluoro-2-deoxy-D-glucose (FDG)-PET/computed tomography (CT) results.
  
  
  RESULTS
  EDIM-TKTL1 score and FDG-PET results showed a concordance of 90% with a sensitivity of 94% and specificity of 81%. Including CT data, all values were enhanced. A subgroup analysis of non-small-cell lung cancer patients showed a significant correlation between the EDIM-TKTL1 score and the primary tumor size determined by FDG-PET/CT.
  
  
  CONCLUSIONS
  EDIM-TKTL1 blood test revealed good concordance with FDG-PET/CT results in patients with malignancies demonstrating its efficacy to detect upregulation of glucose metabolism in primary tumors or metastases.
authors.affiliation: TAVARLIN AG, Landwehrstrasse 54, D-64293 Darmstadt, Germany. o.feyen@tavarlin.de
authors.forename: Oliver
authors.initials: O
authors.lastname: Feyen
authors.forename: Johannes F
authors.initials: JF
authors.lastname: Coy
authors.forename: Vikas
authors.initials: V
authors.lastname: Prasad
authors.forename: Ralf
authors.initials: R
authors.lastname: Schierl
authors.forename: Joerg
authors.initials: J
authors.lastname: Saenger
authors.forename: Richard P
authors.initials: RP
authors.lastname: Baum
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000097:blood; D000939:Epitopes / Q000097:blood; D005260:Female; D005947:Glucose / Q000378:metabolism*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009000:Monocytes / Q000378:metabolism*; D009369:Neoplasms / Q000097:blood / Q000473:pathology; D014057:Tomography, X-Ray Computed; D014174:Transketolase / Q000097:blood*
chemical_list: D014408:Biomarkers, Tumor; D000939:Epitopes; C505431:TKTL1 protein, human; D014174:Transketolase; D005947:Glucose