title: Phylogeography of swine influenza H3N2 in the United States: translational public health for zoonotic disease surveillance.
abstract: The field of phylogeography has received a lot of attention for its application to molecular evolution and geographic migration of species. More recent work has included infectious diseases especially zoonotic RNA viruses like influenza and rabies. Phylogeography of viruses has the potential to advance surveillance at agencies such as public health departments, agriculture departments, and wildlife agencies. However, little is known about how these agencies could use phylogeography for applied surveillance and the integration of animal and human sequence data. Here, we highlight its potential to support 'translational public health' that could bring sequence data to the forefront of surveillance. We focus on swine influenza H3N2 because of the recent link to a variant form that has also infected humans. We discuss the implications to applied surveillance and the need for an integrated biomedical informatics approach for adoption at agencies of animal and public health.
authors.affiliation: Department of Biomedical Informatics, Arizona State University, Scottsdale, AZ 85259, USA. matthew.scotch@asu.edu
authors.forename: Matthew
authors.initials: M
authors.lastname: Scotch
authors.forename: Changjiang
authors.initials: C
authors.lastname: Mei
mesh_terms: D000818:Animals; D019267:Hemagglutinin Glycoproteins, Influenza Virus / Q000235:genetics; D006801:Humans; D053122:Influenza A Virus, H3N2 Subtype / Q000235:genetics*; D009976:Orthomyxoviridae Infections / Q000662:veterinary; D010802:Phylogeny; D058974:Phylogeography; D062486:Public Health Surveillance; D013552:Swine; D013553:Swine Diseases / Q000453:epidemiology; D014481:United States / Q000453:epidemiology; D015047:Zoonoses / Q000453:epidemiology
chemical_list: D019267:Hemagglutinin Glycoproteins, Influenza Virus