title: Modified laryngotracheal separation for intractable aspiration pneumonia in patients with nasopharyngeal carcinoma treated by radiotherapy.
abstract: OBJECTIVE
  Intractable aspiration pneumonia in patients with post-radiotherapeutic nasopharyngeal carcinoma (PNC) is a formidable complication, but has not attracted enough attention in clinical practice. Modified laryngotracheal separation (MLTS) was applied for these patients in our hospital, the surgical effects of which were assessed.
  
  
  METHODS
  Retrospective analysis of 9 PNC cases complicated by intractable aspiration pneumonia in our hospital was carried out. All cases were diagnosed as lower cranial nerve palsy. Their aspiration pneumonia was not effectively prevented or controlled after a series of previous treatments, including active anti-infectives, neurotrophy, acupuncture, nutrition support, nasogastric feeding and tracheotomy. Ultimately all of them received modified laryngotracheal separation (MLTS) surgery. Efficacy of the operation was assessed.
  
  
  RESULTS
  In all patients, aspiration pneumonia was effectively controlled after the operation, body weights increased more than 6kg six months later, and nutrition status, swallowing function and quality of life were all improved.
  
  
  CONCLUSIONS
  Intractable post-radiotherapeutic aspiration pneumonia in patients with nasopharyngeal carcinoma was possibly caused by lower cranial nerve palsy, which might be related to radiation fields overlapped. Modified laryngotracheal separation is effective in eliminating intractable aspiration in PNC. Suitable patients should be carefully selected although the procedure is potentially reversible.
authors.affiliation: Otorhinolaryngology Hospital, Otorhinolaryngology Institute, The First Affiliated Hospital, Sun Yat-sen University, Zhong shan 2nd Road 58, Guangzhou, Guangdong, PR China.
authors.forename: Wenbin
authors.initials: W
authors.lastname: Lei
authors.forename: Liping
authors.initials: L
authors.lastname: Chai
authors.forename: Jiebo
authors.initials: J
authors.lastname: Guo
authors.forename: Yuan-Ping
authors.initials: YP
authors.lastname: Zhu
authors.forename: Xiaolin
authors.initials: X
authors.lastname: Zhu
authors.forename: Aiyun
authors.initials: A
authors.lastname: Jiang
authors.forename: Weiping
authors.initials: W
authors.lastname: Wen
authors.forename: Zhenzhong
authors.initials: Z
authors.lastname: Su
mesh_terms: D000368:Aged; D002277:Carcinoma / Q000532:radiotherapy; D003389:Cranial Nerve Diseases / Q000150:complications / Q000209:etiology; D003680:Deglutition Disorders / Q000209:etiology / Q000601:surgery; D006801:Humans; D007830:Larynx / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D009303:Nasopharyngeal Neoplasms / Q000532:radiotherapy; D009334:Neck Muscles / Q000637:transplantation; D009752:Nutritional Status; D013517:Otorhinolaryngologic Surgical Procedures / Q000379:methods*; D011015:Pneumonia, Aspiration / Q000209:etiology / Q000601:surgery*; D011788:Quality of Life; D011878:Radiotherapy / Q000009:adverse effects*; D020545:Respiratory Mucosa / Q000601:surgery; D012189:Retrospective Studies; D014132:Trachea / Q000601:surgery*