title: Association between KCNE1 (G38S) genetic polymorphism and non-valvular atrial fibrillation in an Uygur population.
abstract: BACKGROUND
  The relationship between KCNE1 G38S genetic polymorphism and non-valvular atrial fibrillation is different among different populations. The study explored the KCNE1 G38S to understand if the KCNE1 G38S is associated with the Uygur atrial fibrillation patients.
  
  
  METHODS
  KCNE1 G38S genetic polymorphism was determined between 237 non-valvular atrial fibrillation cases and 237 control subjects using PCR-RFLP.
  
  
  RESULTS
  In univariate analyses, there was a statistical difference in genotype distribution between the patients and controls, and a significant difference in allele frequency of KCNE1 G38S was observed between the two groups (62.6 vs 52.7 %, p = 0.003). In multivariate analyses, the KCNE1 38G variant was independently associated with a significant predisposing effect on AF after adjusting for related risk factors, and the odds ratio for patients was 1.634 (95 % CI: 1.192-2.240, p = 0.002).
  
  
  CONCLUSIONS
  The KCNE1 38G is a risk factor for incident AF in an Uygur population. The KCNE1 G38S might have different impact on AF in different ethnicities.
authors.affiliation: The Cardiac Pacing and Electrophysiological Division, The first teaching hospital of Xinjiang Medical University, 830054 Urumqi, China. mhjmex@163.com
authors.forename: Miao
authors.initials: M
authors.lastname: Haijun
authors.forename: Zhou
authors.initials: Z
authors.lastname: Xiaohui
authors.forename: Mao
authors.initials: M
authors.lastname: Ting
authors.forename: Wilfried
authors.initials: W
authors.lastname: Renner
authors.forename: Palida
authors.initials: P
authors.lastname: Abulizi
authors.forename: Tang
authors.initials: T
authors.lastname: Baopeng
mesh_terms: D000368:Aged; D001281:Atrial Fibrillation / Q000208:ethnology* / Q000235:genetics*; D002681:China / Q000453:epidemiology; D005260:Female; D020022:Genetic Predisposition to Disease / Q000208:ethnology* / Q000235:genetics*; D006349:Heart Valve Diseases / Q000208:ethnology / Q000235:genetics; D006801:Humans; D008297:Male; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D024642:Potassium Channels, Voltage-Gated / Q000235:genetics*; D015995:Prevalence; D012307:Risk Factors
chemical_list: C489622:KCNE1 protein, human; D024642:Potassium Channels, Voltage-Gated