title: Double nucleophilic attack on isocyanide carbon: a synthetic strategy for 7-aza-tetrahydroindoles.
abstract: A novel and efficient route for the synthesis of 7-aza-tetrahydroindoles from N-aryl/alkyl-alkenoylacetamides and ethyl isocyanoacetate is described. A mechanism, involving a stepwise [3+2] cycloaddition-intramolecular aza-Michael addition cascade, is proposed that explains the origin of the double nucleophilic attack on the isocyanide carbon atom.
authors.affiliation: Department of Chemistry, Northeast Normal University, Changchun 130024, China.
authors.forename: Yifei
authors.initials: Y
authors.lastname: Li
authors.forename: Xianxiu
authors.initials: X
authors.lastname: Xu
authors.forename: Chunyu
authors.initials: C
authors.lastname: Xia
authors.forename: Lingjuan
authors.initials: L
authors.lastname: Zhang
authors.forename: Ling
authors.initials: L
authors.lastname: Pan
authors.forename: Qun
authors.initials: Q
authors.lastname: Liu