title: The missing link: Mul1 signals mitophagy and muscle wasting.
abstract: FoxO3 regulates the transcription of autophagy-related genes that induce mitophagy in muscle wasting. In this issue of Cell Metabolism, Lokireddy et al. (2012) now show that the mitochondrial ubiquitin protein ligase 1 (Mul1) polyubiquitinates the mitochondrial fusion protein Mfn2 and is necessary for FoxO3- and lysosomal-dependent mitophagy in muscle atrophy.
authors.affiliation: INRA, UMR 1019 Nutrition Humaine et Clermont Université, UFR Médecine, UMR 1019 Nutrition Humaine, 63000 Clermont-Ferrand, France. didier.attaix@clermont.inra.fr
authors.forename: Didier
authors.initials: D
authors.lastname: Attaix
authors.forename: Daniel
authors.initials: D
authors.lastname: Taillandier