title: Alterations in the cortical thickness and the amplitude of low-frequency fluctuation in patients with post-traumatic stress disorder.
abstract: The core neuropsychological processes underlying post-traumatic stress disorder (PTSD) have yet to be elucidated, and the association between anatomical and functional deficits in PTSD remains largely unknown. The aim of our study was to investigate the alterations in cortical thickness and amplitude of low-frequency fluctuation (ALFF) in PTSD patients resulting from motor vehicle accidents (MVCs), and to explore the association of cortical thickness and ALFF with the severity of PTSD symptoms. A total of 20 PTSD patients and 20 healthy controls were recruited and examined by high-resolution structural MRI combined with resting-state fMRI. The results showed significant decrease in cortical thickness in the left BA10, BA32 and BA45 and the right superior temporal gyrus in PTSD patients. The ALFF value in PTSD patients increased significantly in the left BA10 and BA32 and the right cerebellum. Linear regression revealed that decreased cortical thickness and increased ALFF in the BA10 were associated with the increased PTSD scores. These findings suggest that the structural integrity and resting-state function in the BA10 play an important role in the pathogenesis of PTSD.
authors.affiliation: Department of Anatomy, Third Military Medical University, 30 Gaotanyan street, Chongqing 400038, China.
authors.forename: Xie
authors.initials: X
authors.lastname: Bing
authors.forename: Qiu
authors.initials: Q
authors.lastname: Ming-Guo
authors.forename: Zhang
authors.initials: Z
authors.lastname: Ye
authors.forename: Zhang
authors.initials: Z
authors.lastname: Jing-Na
authors.forename: Li
authors.initials: L
authors.lastname: Min
authors.forename: Chen
authors.initials: C
authors.lastname: Han
authors.forename: Zhang
authors.initials: Z
authors.lastname: Yu
authors.forename: Zhang
authors.initials: Z
authors.lastname: Jia-Jia
authors.forename: Wang
authors.initials: W
authors.lastname: Jian
authors.forename: Chen
authors.initials: C
authors.lastname: Wei
authors.forename: Du
authors.initials: D
authors.lastname: Han-Jian
authors.forename: Zhang
authors.initials: Z
authors.lastname: Shao-Xiang
mesh_terms: D000063:Accidents, Traffic / Q000523:psychology; D000293:Adolescent; D000328:Adult; D001931:Brain Mapping; D002531:Cerebellum / Q000473:pathology; D002540:Cerebral Cortex / Q000473:pathology*; D003627:Data Interpretation, Statistical; D039721:Diagnostic and Statistical Manual of Mental Disorders; D004522:Educational Status; D055724:Electrophysiological Phenomena; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted; D007361:Intelligence Tests; D008279:Magnetic Resonance Imaging; D008297:Male; D012044:Regression Analysis; D013313:Stress Disorders, Post-Traumatic / Q000473:pathology*; D055815:Young Adult