title: [Experimental study on ectopic prefabrication of vascularized mandible graft with autogenous ribs].
abstract: OBJECTIVE
  To explore a method for ectopic prefabrication of mandible with vascular pedicle.
  
  
  METHODS
  Cancellous bone blocks harvested from the dog ribs were packaged with mandible-shaped titanium mesh scaffold and implanted into latissimus dorsi of dog with thoracodorsal artery and vein through the scaffold. After 12 weeks, bone formation and vascularization were evaluated by gross inspection, histological examination and immunohistochemistry.
  
  
  RESULTS
  Vascularized mandible with thoracodorsal artery and vein were formed and histological staining and immunohistochemisty confirmed new bone formation and vascularization.
  
  
  CONCLUSIONS
  There is feasibility for ectopic prefabrication of vascularized mandible graft using cancellous ribs, which provides a new method for mandibular defect reconstruction. Experimental study on ectopic prefabrication of vascularized mandible graft with autogenous ribs.
authors.affiliation: Department of Oral and Maxillofacial Surgery, School of Stomatology, Wuhan University, Wuhan 430079, China.
authors.forename: Xiang
authors.initials: X
authors.lastname: Wang
authors.forename: Zhe
authors.initials: Z
authors.lastname: Shao
authors.forename: Han-zhong
authors.initials: HZ
authors.lastname: Zhang
authors.forename: Fei
authors.initials: F
authors.lastname: Zhu
authors.forename: Hui
authors.initials: H
authors.lastname: Shen
authors.forename: Zheng-jun
authors.initials: ZJ
authors.lastname: Shang
mesh_terms: D000818:Animals; D016025:Bone Transplantation / Q000379:methods*; D004285:Dogs; D005260:Female; D008297:Male; D008334:Mandible / Q000601:surgery*; D010012:Osteogenesis; D019651:Plastic Surgery Procedures / Q000379:methods; D012272:Ribs / Q000601:surgery*; D023822:Tissue Engineering / Q000379:methods*; D014182:Transplantation, Autologous