title: A defect in vasopressin secretion in autosomal dominant polycystic kidney disease.
abstract: A nephrogenic defect in urine concentration is well established in patients with polycystic kidney disease, but Ho et al. report a defect in the increase of plasma vasopressin in response to dehydration. On a cellular level, transient receptor potential channels responsible for osmoperception could interact with TRPPs encoded by the polycystic genes PKD1 and PKD2.
authors.affiliation: Department of Physiology and Medicine, Hôpital du Sacré-Coeur, Université de Montréal, Montréal, Canada.
authors.forename: Daniel G
authors.initials: DG
authors.lastname: Bichet
mesh_terms: D005260:Female; D006801:Humans; D007031:Hypothalamus / Q000503:physiopathology*; D007668:Kidney / Q000503:physiopathology*; D008297:Male; D064587:Osmoregulation; D016891:Polycystic Kidney, Autosomal Dominant / Q000503:physiopathology*