title: [Study on chronic health conditions and its related risk factors in recipients after hematopoietic stem cell transplantation].
abstract: OBJECTIVE
  To study the chronic health conditions (CHC) in long-term survival recipient after hematopoietic stem cell transplantation (HSCT).
  
  
  METHODS
  The CHC of 101 cases survived for more than 1 year after HSCT were collected according to Bone Marrow Transplant Survivor Study (MBMTSS) questionnaire. The differences of the incidence and severity of CHC between auto-HSCT and allo-HSCT, HLA-matched and HLA-mismatched family donors HSCT were compared, and risk factors related to chronic health conditions were analyzed retrospectively in family donor HSCT.
  
  
  RESULTS
  Of the 101 HSCT survivors, 48.5% reported one or more chronic health conditions, and 83.7% of which were mild to moderate. The CHC in HLA-matched related donors HSCT were more serious than in HLA-mismatched related donors HSCT. The percentage of CHC total score above 3 in allo-HSCT recipients (32.1%) was higher than that in auto-HSCT ones (10.0%). The percentage of CHC total score 1-2, 3-4, and above 5 in HLA-matched family donors HSCT were 23.5%, 29.4%, and 14.7%, respectively, being significantly higher than those in HLA-mismatched ones (15.6%, 15.6%, and 6.2%, respectively). CHC was mainly related to chronic graft-versus-host disease (cGVHD). Single variable analysis showed that younger age at time of transplantation, HLA fully matched, the use of antithymocyte globulin (ATG) in the conditioning regimens were favorable for CHC. COX-regression Model showed that age was the only independent risk factor for predicting the CHC in family donor HSCT.
  
  
  CONCLUSIONS
  The chronic health conditions after HSCT is mild to moderate, these complications in HLA-matched related donor HSCT are more serious than those in HLA-mismatched related donor HSCT. The age at transplantation is the only independent risk factor for chronic health conditions.
authors.affiliation: Department of Hematology, Peking University First Hospital, Beijing, China.
authors.forename: Jian-jun
authors.initials: JJ
authors.lastname: Song
authors.forename: Han-yun
authors.initials: HY
authors.lastname: Ren
authors.forename: Zhi-xiang
authors.initials: ZX
authors.lastname: Qiu
authors.forename: Mang-ju
authors.initials: MJ
authors.lastname: Wang
authors.forename: Wei-lin
authors.initials: WL
authors.lastname: Xu
authors.forename: Wei
authors.initials: W
authors.lastname: Liu
authors.forename: Yuan
authors.initials: Y
authors.lastname: Li
authors.forename: Yu-jun
authors.initials: YJ
authors.lastname: Dong
authors.forename: Yue
authors.initials: Y
authors.lastname: Yin
authors.forename: Yu-hua
authors.initials: YH
authors.lastname: Sun
authors.forename: Li-hong
authors.initials: LH
authors.lastname: Wang
authors.forename: Jin-ping
authors.initials: JP
authors.lastname: Ou
authors.forename: Wen-sheng
authors.initials: WS
authors.lastname: Wang
authors.forename: Xi-nan
authors.initials: XN
authors.lastname: Cen
mesh_terms: D000293:Adolescent; D000328:Adult; D002648:Child; D002675:Child, Preschool; D002908:Chronic Disease / Q000453:epidemiology*; D005260:Female; D018380:Hematopoietic Stem Cell Transplantation / Q000009:adverse effects*; D006801:Humans; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D012307:Risk Factors; D014019:Tissue Donors; D019172:Transplantation Conditioning; D055815:Young Adult