title: Male Child with Van Wyk-Grumbach's Syndrome and Other Complications of Long-Standing Primary Hypothyroidism: A Case Report.
abstract: Primary hypothyroidism in the juvenile population generally leads to retardation of linear growth and delay or even arrest of puberty. However, in rare conditions, children with long-standing hypothyroidism present with signs of Van Wyk-Grumbach's syndrome (VWGS) which include juvenile hypothyroidism, delayed bone age, and pseudoprecocious puberty. We report a rare case of prepubertal male child from Asian origin, presented with long-standing untreated hypothyroidism complicated with VWGS and other complications including obesity, short stature, hepatomegaly, asymptomatic mild pericardial effusion, and pituitary hyperplasia.
authors.affiliation: Department of Pediatrics, Xiangya Hospital of Central South University, No. 87 Xiangya Road, Changsha, Hunan 410008, China ; Department of Pediatrics and Neonatology, Suez Canal University, Ismailia 41522, Egypt.
authors.forename: Ahmed
authors.initials: A
authors.lastname: Omran
authors.forename: Jing
authors.initials: J
authors.lastname: Peng
authors.forename: Biswas
authors.initials: B
authors.lastname: Shrestha
authors.forename: Muhammad Usman
authors.initials: MU
authors.lastname: Ashhab
authors.forename: Fei
authors.initials: F
authors.lastname: Yin