title: [Role of semicarbazide-sensitive amine oxidase in disturbances of endogenic detoxication in ischemic stroke patients].
abstract: Oxidative stress is a pathogenetic factor of ischemic stroke. Enhancement in the activity of one of xenobiotic transformation enzymes and biogenic amines (serum semicarbazide-sensitive amine oxidase (SSAO)) leads to the higher production of secondary toxins stimulating oxidative stress. We studied 38 patients (mean age 69,5 +/- 7,2 years) in the early restoration period of ischemic stroke. A control group included 17 age- and sex-matched healthy people. Severity of neurological and functional deficits was assessed with the NIHSS and the Barthel index, respectively. A number of biochemical parameters: serum SSAO activity, concentration of middle-sized molecules (MSM) and malonic dialdehyde (MDA) were measured. The higher concentration of MSM (0,80 +/- 0,22 and 0,5 +/- 0,1 g/l) and MDA (4,5 +/- 1,25 and 3,66 +/- 0,15 mmol/ml), respectively, was found in patients compared to the controls (p < 0,001). The correlative increase in MSM and MDA suggest the formation of chronic oxidative stress in the 4-5 months of disease. The changes in SSAO activity in patients with ischemic stroke that differed from controls were seen in 84% of cases while the increase in SSAO activity was found in 31% of patients. The pathogenetic link between the increase in SSAO activity and severity of neurological deficit was shown. This increase might be one of the pathogenetic links in the disturbance of neuroplasticity.
authors.forename: V V
authors.initials: VV
authors.lastname: Alferova
authors.forename: M G
authors.initials: MG
authors.lastname: Uzbekov
authors.forename: V M
authors.initials: VM
authors.lastname: Shklovskiĭ
authors.forename: E Iu
authors.initials: EIu
authors.lastname: Misionzhnik
authors.forename: E V
authors.initials: EV
authors.lastname: Luk'ianiuk
authors.forename: A B
authors.initials: AB
authors.lastname: Gekht
mesh_terms: D000368:Aged; D006631:Amine Oxidase (Copper-Containing) / Q000097:blood / Q000378:metabolism*; D005260:Female; D006801:Humans; D008297:Male; D008315:Malondialdehyde / Q000097:blood; D008875:Middle Aged; D009473:Neuronal Plasticity; D018384:Oxidative Stress; D020127:Recovery of Function; D012720:Severity of Illness Index; D020521:Stroke / Q000097:blood / Q000201:enzymology* / Q000503:physiopathology*
chemical_list: D008315:Malondialdehyde; D006631:Amine Oxidase (Copper-Containing)