title: Quality of life in obsessive-compulsive disorder: the role of mediating variables.
abstract: This study examined the association of various clinical features of obsessive-compulsive disorder (OCD) with quality of life (QoL) in 102 adults with a principal diagnosis of OCD. Participants were assessed by trained clinicians using the Anxiety Disorders Interview Schedule 4th edition, the Yale-Brown Obsessive-Compulsive Scale, and an unstructured clinical interview. Subjects completed the MOS-36 Item Short Form Health Survey, and Beck Depression Inventory-II. Obsessive-compulsive symptom severity was negatively correlated with emotional health, social functioning and general health QoL. Depressive symptoms mediated the relationship between obsessive-compulsive symptom severity and emotional health, social functioning and general health QoL. Additionally, interference of obsessive-compulsive symptoms mediated the relationship between obsessive-compulsive symptom severity and emotional health, social functioning and general health QoL. Resistance against obsessive-compulsive symptoms mediated the relationship between obsessive-compulsive symptom severity and social functioning QoL. Diminished QoL is present in persons with OCD and is essential in understanding the complete clinical picture of OCD.
authors.affiliation: Department of Psychology, University of South Florida, 4202 E. Fowler Avenue, Tampa, FL 33620, USA.
authors.forename: Brittany B
authors.initials: BB
authors.lastname: Kugler
authors.forename: Adam B
authors.initials: AB
authors.lastname: Lewin
authors.forename: Vicky
authors.initials: V
authors.lastname: Phares
authors.forename: Gary R
authors.initials: GR
authors.lastname: Geffken
authors.forename: Tanya K
authors.initials: TK
authors.lastname: Murphy
authors.forename: Eric A
authors.initials: EA
authors.lastname: Storch
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D005260:Female; D006306:Health Surveys; D006801:Humans; D008297:Male; D008875:Middle Aged; D017008:Negotiating / Q000379:methods*; D009771:Obsessive-Compulsive Disorder / Q000523:psychology* / Q000534:rehabilitation*; D011569:Psychiatric Status Rating Scales; D011788:Quality of Life; D013223:Statistics as Topic; D055815:Young Adult