title: Fasting blood glucose and lipid profile alterations following twelve-month androgen deprivation therapy in men with prostate cancer.
abstract: OBJECTIVE
  In this retrospective study, we aimed to investigate the effects of androgen deprivation therapy (ADT) on blood glucose and blood cholesterol levels over a 12-month period.
  
  
  METHODS
  Between January 2010 and June 2012, the data of 44 patients with prostate cancer who were receiving ADT were collected from a hospital database. Patients with additional malignancy or diabetes and those who had been prescribed and were currently taking cholesterol-lowering medication were excluded from the study. Data (including fasting blood glucose levels and a cholesterol profile) were collected and analysed statistically. A P value <0.05 was considered statistically significant.
  
  
  RESULTS
  Twelve months after the initiation of ADT, fasting blood glucose (FBG), total cholesterol (TC), low-density lipoprotein (LDL) cholesterol, high-density lipoprotein (HDL) cholesterol, and triglyceride (TG) levels changed. FBG, TC, LDL cholesterol, and TG increased significantly (P = 0.009, 0.000, 0.000, and 0.000, resp.), while HDL cholesterol decreased (P = 0.000).
  
  
  CONCLUSIONS
  ADT may increase FBG, TC, LDL cholesterol, and TG but decrease HDL cholesterol by the end of a year of treatment. Therefore, close followup may be needed as a consequence of one-year ADT regarding metabolic alterations.
authors.affiliation: Urology Department, Medical Faculty, Sakarya University, Sakarya, Turkey. hasanss@hotmail.com
authors.forename: Hasan S
authors.initials: HS
authors.lastname: Sağlam
authors.forename: Osman
authors.initials: O
authors.lastname: Köse
authors.forename: Sükrü
authors.initials: S
authors.lastname: Kumsar
authors.forename: Salih
authors.initials: S
authors.lastname: Budak
authors.forename: Oztuğ
authors.initials: O
authors.lastname: Adsan
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000726:Androgen Antagonists / Q000627:therapeutic use; D000728:Androgens / Q000172:deficiency*; D001786:Blood Glucose / Q000187:drug effects*; D002784:Cholesterol / Q000097:blood; D005215:Fasting; D006801:Humans; D008055:Lipids / Q000097:blood*; D008297:Male; D009919:Orchiectomy; D011471:Prostatic Neoplasms / Q000097:blood* / Q000188:drug therapy* / Q000601:surgery; D012189:Retrospective Studies
chemical_list: D000726:Androgen Antagonists; D000728:Androgens; D001786:Blood Glucose; D008055:Lipids; D002784:Cholesterol