title: Chemoselective cross-coupling reactions with differentiation between two nucleophilic sites on a single aromatic substrate.
abstract: A new thiophene building block, containing both a stannyl group and a boronic ester, was prepared. From this starting material, a general, nucleophile-selective one-pot reaction was developed, exploiting the different reactivities of the Stille and Suzuki-Miyaura cross-coupling reactions. A series of aromatic electrophiles were used to demonstrate the high functional group tolerance.
authors.affiliation: Otto-Diels-Institut für Organische Chemie, Universität Kiel, Otto-Hahn-Platz 4, 24118 Kiel, Germany.
authors.forename: Julian
authors.initials: J
authors.lastname: Linshoeft
authors.forename: Annika C J
authors.initials: AC
authors.lastname: Heinrich
authors.forename: Stephan A W
authors.initials: SA
authors.lastname: Segler
authors.forename: Paul J
authors.initials: PJ
authors.lastname: Gates
authors.forename: Anne
authors.initials: A
authors.lastname: Staubitz