title: Response to vitamin D3 supplementation in obese and non-obese Caucasian adolescents.
abstract: OBJECTIVE
  Vitamin D deficiency is highly prevalent in obese children, and obese children tend to respond poorly to vitamin D supplementation. The objective of the study was to compare the response to vitamin D(3) supplementation (2,000 IU once daily for 12 weeks) between obese and non-obese Caucasian adolescents.
  
  
  METHODS
  The study design was open label non-randomized. It was carried out at a single center. Eighteen obese adolescents (aged 12-18 years) and the same number of age-, gender- and season-matched non-obese adolescents received vitamin D(3) (2,000 IU/day) orally for 12 weeks. Total serum 25-hydroxyvitamin D [25(OH)D], parathyroid hormone, calcium and phosphorus were measured at baseline and at the end of the 12-week period.
  
  
  RESULTS
  The mean baseline 25(OH)D level was higher in the non-obese compared to the obese subjects (mean 28.9 vs. 25.2 ng/ml; p = 0.029). The increment in 25(OH)D levels following vitamin D supplementation was significantly lower in the obese adolescents (mean change 5.8 vs. 9.8 ng/ml; p = 0.019).
  
  
  CONCLUSIONS
  Higher doses of vitamin D are required to treat vitamin D deficiency in obese adolescents compared to their non-obese peers.
authors.affiliation: Division of Pediatric Endocrinology and Metabolism, Mayo Clinic College of Medicine, Rochester, Minn., USA.
authors.forename: Roxana
authors.initials: R
authors.lastname: Aguirre Castaneda
authors.forename: Nicole
authors.initials: N
authors.lastname: Nader
authors.forename: Amy
authors.initials: A
authors.lastname: Weaver
authors.forename: Ravinder
authors.initials: R
authors.lastname: Singh
authors.forename: Seema
authors.initials: S
authors.lastname: Kumar
mesh_terms: D000293:Adolescent; D015992:Body Mass Index; D002648:Child; D002762:Cholecalciferol / Q000008:administration & dosage / Q000494:pharmacology*; D019587:Dietary Supplements; D005260:Female; D006801:Humans; D056865:Ideal Body Weight / Q000502:physiology; D008297:Male; D009765:Obesity / Q000150:complications / Q000188:drug therapy* / Q000453:epidemiology / Q000208:ethnology; D015995:Prevalence; D012621:Seasons; D014808:Vitamin D Deficiency / Q000097:blood / Q000188:drug therapy* / Q000453:epidemiology / Q000208:ethnology; D044465:White People; D016903:Drug Monitoring
chemical_list: D002762:Cholecalciferol