title: [Study on intestinal absorption kinetics of gambogic acid in rats].
abstract: OBJECTIVE
  To investigate the intestinal absorption kinetics of gambogic acid (GA) in rats.
  
  
  METHODS
  In situ single-way intestinal perfusion model was established to study the intestinal absorption kinetics of GA in different absorption segments, and the concentration of GA in the perfusate was determined by HPLC. The effect of drug concentrations on intestinal absorption was also detected.
  
  
  RESULTS
  GA showed a higher absorption rate than other intestinal segments (P < 0.05) and kept unchanged in duodenum after addition in drug concentration.
  
  
  CONCLUSIONS
  GA can be absorbed in all intestinal segments in rats with the higher absorption rate in duodenum. Its mechanism is passive diffusion.
authors.affiliation: Department of Pharmaceutics of China Pharmaceutical University, Nanjing 210029, China. hnsqwxp@163.com
authors.forename: Xiaopan
authors.initials: X
authors.lastname: Wang
authors.forename: Huixia
authors.initials: H
authors.lastname: Lv
authors.forename: Ayman Y
authors.initials: AY
authors.lastname: Waddad
authors.forename: Fan
authors.initials: F
authors.lastname: Yu
authors.forename: Jianping
authors.initials: J
authors.lastname: Zhou
mesh_terms: D000818:Animals; D002851:Chromatography, High Pressure Liquid; D007408:Intestinal Absorption; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D044004:Xanthones / Q000493:pharmacokinetics*
chemical_list: D044004:Xanthones; C052659:gambogic acid