title: Colchicine and NSAID combination causing acute kidney injury.
abstract: Colchicine is used mainly for the treatment of gout and familial mediterranean fever. The use of colchicine is limited by its toxicity, and colchicine overdose is associated with a high mortality rate. Herein, we are reporting a young man who presented to the emergency department after ingesting 13.5 mg of colchicine and 1200 mg of aceclofenac (non-steroid anti-inflammatory drug) for deliberate self harm. He developed acute kidney injury, metabolic acidosis, and bradycardia after admission. A combination effect of non-steroid anti-inflammatory drug and colchicines was responsible for this event.
authors.affiliation: Department of Internal Medicine, Tri-Service General Hospital, Taipei, Taiwan.
authors.forename: Hsuan-Wei
authors.initials: HW
authors.lastname: Chen
authors.forename: Kuan-Chan
authors.initials: KC
authors.lastname: Chen
authors.forename: Jin-Shuen
authors.initials: JS
authors.lastname: Chen
mesh_terms: D058186:Acute Kidney Injury / Q000139:chemically induced* / Q000175:diagnosis; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage / Q000506:poisoning*; D015210:Arthritis, Gouty / Q000188:drug therapy*; D002606:Charcoal / Q000008:administration & dosage; D003078:Colchicine / Q000008:administration & dosage / Q000506:poisoning*; D062787:Drug Overdose / Q000175:diagnosis / Q000628:therapy; D005751:Gastric Lavage; D006801:Humans; D008297:Male; D013406:Suicide, Attempted; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D002606:Charcoal; D003078:Colchicine