title: Relationship of fasting total homocysteine, high sensitivity C-reactive protein and features of the metabolic syndrome in Trinidadian subjects.
abstract: OBJECTIVE
  To assess the relationship of homocysteine, hs-CRP, with known cardiovascular risk factors of the metabolic syndrome.
  
  
  METHODS
  Cross sectional study comprised 182 diabetic outpatients (70 males and 112 females), attending endocrinology clinics in Trinidad.
  
  
  RESULTS
  Both male and females showed significant linear relationships between high sensitive C-reactive protein (hs-CRP), blood pressure and diabetes (r = -0.2 < R or R > 0.2). In females hs-CRP showed significant linear relationship with HDL, triglyceride, blood pressure and diabetes mellitus (p < 0.0001). The inverse relationship of hs-CRP with HDL implies the strong association of hs-CRP with metabolic syndrome. The multivariate logistic regression analysis showed significant relation of hs-CRP, metabolic syndrome and diabetes mellitus. There was no significant relationship of tHCY to any of the features studied.
  
  
  CONCLUSIONS
  Serum C-reactive protein is significantly related to features of the metabolic syndrome. Total plasma homocysteine, appears to be independent of both hs-CRP and features of the metabolic syndrome.
authors.affiliation: Department of Preclinical Sciences, The University of the West Indies, St Augustine, Trinidad and Tobago. shivananda.Nayak@sta.uwi.edu
authors.forename: B S
authors.initials: BS
authors.lastname: Nayak
authors.forename: L M
authors.initials: LM
authors.lastname: Pinto Pereira
authors.forename: T
authors.initials: T
authors.lastname: Seemungal
authors.forename: G
authors.initials: G
authors.lastname: Davis
authors.forename: S
authors.initials: S
authors.lastname: Teelucksingh
authors.forename: A
authors.initials: A
authors.lastname: Jagessar
authors.forename: G
authors.initials: G
authors.lastname: Legall
mesh_terms: D000328:Adult; D000368:Aged; D015415:Biomarkers / Q000097:blood; D001794:Blood Pressure; D002097:C-Reactive Protein / Q000378:metabolism*; D002318:Cardiovascular Diseases / Q000473:pathology; D003430:Cross-Sectional Studies; D003920:Diabetes Mellitus / Q000473:pathology; D005215:Fasting / Q000097:blood*; D005260:Female; D006710:Homocysteine / Q000097:blood*; D006801:Humans; D008297:Male; D024821:Metabolic Syndrome / Q000453:epidemiology / Q000208:ethnology / Q000473:pathology*; D008875:Middle Aged; D015999:Multivariate Analysis; D012307:Risk Factors; D014300:Trinidad and Tobago / Q000453:epidemiology; D055105:Waist Circumference; D055815:Young Adult
chemical_list: D015415:Biomarkers; D006710:Homocysteine; D002097:C-Reactive Protein