title: [Risk factors for septic shock in patients with solid organ transplantation and complication of bacteremias].
abstract: OBJECTIVE
  To explore the risk factors for septic shock in patients with solid organ transplantation and complication of bacteremias.
  
  
  METHODS
  Clinical data of 98 solid organ transplant cases with complication of bacteremias were retrospectively studied. All episodes of bacteremias met the CDC criteria. Six possible risk factors contributing to septic shock were evaluated by univariate analysis and multivariate logistic regression analysis.
  
  
  RESULTS
  Among the 98 patients, 133 times of bacteremias have been reported and 39 patients developed septic shock. Among the 39 patients with septic shock, 43.5%, 38.5%, 15.4% and 2.6% of bacteremias were induced by multiple bacteria, gram-negative bacteria, gram-positive bacteria and fungi, respectively. The lung was the main source of bacteremias (41.8%), followed by intraabdominal/ biliary focus (24.5%). Risk factors for developing septic shock included the bacteremias happened in the 2nd to 8th week post transplant (P=0.014), polymicrobial etiology (P=0.001), intra-abdominal/ biliary focus (P=0.011), and liver transplant (P=0.002). Only bacteremias occurred in the 2nd to 8th week post transplant and polymicrobial etiology were significant risk factors by multivariate analysis.
  
  
  CONCLUSIONS
  Risk factors for developing septic shock in bacteremias after SOT are early-onset (the 2nd-8th week post transplant) and polymicrobial etiology.
authors.affiliation: Department of Emergency and Critical Care Medicine, Central South University, Changsha, China.
authors.forename: Xuefei
authors.initials: X
authors.lastname: Xiao
authors.forename: Qiquan
authors.initials: Q
authors.lastname: Wan
authors.forename: Qifa
authors.initials: Q
authors.lastname: Ye
authors.forename: Ying
authors.initials: Y
authors.lastname: Ma
authors.forename: Jiandang
authors.initials: J
authors.lastname: Zhou
mesh_terms: D016470:Bacteremia / Q000150:complications*; D006801:Humans; D015999:Multivariate Analysis; D016377:Organ Transplantation / Q000009:adverse effects*; D012189:Retrospective Studies; D012307:Risk Factors; D012772:Shock, Septic / Q000150:complications*