title: Envelope diversity, characteristics of V3 region and predicted co-receptor usage of human immunodeficiency viruses infecting north Indians.
abstract: Subtypes of human immunodeficiency virus type 1 circulating in 21 north Indian patients were characterized based on the partial sequence of the gp120 envelope protein. A majority of viruses (85.7%, 18/21) were subtype C, while 14.3% (3/21) were subtype A. Sequence analysis revealed that the V3 region was highly conserved compared with V4 and V5. The predicted use of co-receptors indicated exclusive usage of R5, except for two subtype A viruses (AIIMS279 and AIIMS281). Our results demonstrate conservation within the V3 loop of subtype C viruses, and suggest the emergence of non-clade C viruses in the north Indian population.
authors.affiliation: Department of Biochemistry, All India Institute of Medical Sciences, New Delhi, India.
authors.forename: Raiees
authors.initials: R
authors.lastname: Andrabi
authors.forename: Rajesh
authors.initials: R
authors.lastname: Kumar
authors.forename: Manju
authors.initials: M
authors.lastname: Bala
authors.forename: Ambili
authors.initials: A
authors.lastname: Nair
authors.forename: Prakash
authors.initials: P
authors.lastname: Ss
authors.forename: Vandana
authors.initials: V
authors.lastname: Kushwaha
authors.forename: Kalpana
authors.initials: K
authors.lastname: Luthra
mesh_terms: D000328:Adult; D020816:Amino Acid Motifs; D000595:Amino Acid Sequence; D005260:Female; D014644:Genetic Variation; D015699:HIV Envelope Protein gp120 / Q000737:chemistry* / Q000235:genetics* / Q000378:metabolism; D015658:HIV Infections / Q000235:genetics / Q000378:metabolism* / Q000821:virology; D015497:HIV-1 / Q000145:classification / Q000235:genetics* / Q000302:isolation & purification* / Q000378:metabolism; D006801:Humans; D007194:India; D008297:Male; D008875:Middle Aged; D008969:Molecular Sequence Data; D010802:Phylogeny; D015728:Receptors, HIV / Q000235:genetics / Q000378:metabolism*; D016415:Sequence Alignment
chemical_list: D015699:HIV Envelope Protein gp120; D015728:Receptors, HIV