title: Mesial temporal lobe epilepsy as a neuropsychiatric syndrome of systemic lupus erythematosus.
abstract: In this study, we aimed to investigate the types of seizures and epilepsy associated with systemic lupus erythematosus (SLE). We searched the medical records at a tertiary referral center to identify a cohort of epilepsy patients with SLE who were treated between January 2000 and August 2011. We analyzed the clinical and immunologic profiles of these patients, their seizure and epilepsy classifications, electroencephalography (EEG) and magnetic resonance imaging (MRI) assessments, and the treatment administered for epilepsy and SLE. As the result, 17 patients with SLE and epilepsy were identified. Seven patients had mesial temporal lobe epilepsy (MTLE), eight had epilepsy secondary to stroke, and two had generalized epilepsy. Of the seven patients with MTLE, anteriotemporal spikes were noted in all patients with EEG, and MRI findings suggesting hippocampal sclerosis were noted in four patients. Clobazam and levetiracetam were effective in treating three patients, and one patient underwent amygdalohippocampectomy. In conclusion, MTLE may be a characteristic manifestation of neuropsychiatric syndrome of systemic lupus erythematosus.
authors.affiliation: Department of Neurology, University of Occupational and Environmental Health School of Medicine, Kitakyushu, Japan.
authors.forename: Tomoko
authors.initials: T
authors.lastname: Toyota
authors.forename: Naoki
authors.initials: N
authors.lastname: Akamatsu
authors.forename: Akihiro
authors.initials: A
authors.lastname: Tanaka
authors.forename: Taisaku
authors.initials: T
authors.lastname: Shouzaki
authors.forename: Sadatoshi
authors.initials: S
authors.lastname: Tsuji
authors.forename: Kazuyoshi
authors.initials: K
authors.lastname: Saito
authors.forename: Yoshiya
authors.initials: Y
authors.lastname: Tanaka
mesh_terms: D000293:Adolescent; D000328:Adult; D015331:Cohort Studies; D004569:Electroencephalography / Q000379:methods; D004833:Epilepsy, Temporal Lobe / Q000453:epidemiology* / Q000503:physiopathology / Q000523:psychology*; D005260:Female; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000453:epidemiology* / Q000503:physiopathology / Q000523:psychology*; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D001523:Mental Disorders / Q000453:epidemiology / Q000503:physiopathology / Q000523:psychology; D008875:Middle Aged; D012189:Retrospective Studies; D013577:Syndrome; D055815:Young Adult