title: Determinants of coronary collateral circulation in patients with coronary artery disease.
abstract: OBJECTIVE
  This study aims to identify possible determinants of coronary collaterals in patients with severe coronary artery disease.
  
  
  METHODS
  The current study has a retrospective cohort design. Seventy four patients with ≥90% stenosis or total occlusion of the left anterior descending artery (LAD) were enrolled; coronary collateral grades, high-sensitive C-reactive protein (hs-CRP), fibrinogen, protein C and S, lipids, uric acid levels and medications applied before coronary angiography were noted and compared. Multiple logistic regression analysis was used for the multivariate analyses of independent variables associated with the development of adequate coronary collateral vessels.
  
  
  RESULTS
  The presence of coronary collaterals was significantly higher in males (p=0.018), with higher hs-CRP (p=0.023), prior statin use (p=0.022), and higher Gensini scores (p<0.001). In multiple logistic regression analysis, hs-CRP levels (OR=0.94, 95.0% CI=0.883-1.000, p=0.048), male gender (OR=4.73, 95.0% CI=1.441-15.539, p=0.010) and prior statin usage (OR=4.70, 95.0% CI=1.264-17.452, p=0.021) were identified as independent predictors of coronary collateral development.
  
  
  CONCLUSIONS
  Male gender, prior statin usage, and higher hs-CRP levels are determinants of coronary collaterals in patients with coronary artery disease.
authors.affiliation: Clinic of Cardiology, Yedikule Thoracic Diseases and Surgery, Education and Research Hospital, İstanbul-Turkey. dremre_akkaya@hotmail.com
authors.forename: Cafer
authors.initials: C
authors.lastname: Zorkun
authors.forename: Emre
authors.initials: E
authors.lastname: Akkaya
authors.forename: Ali
authors.initials: A
authors.lastname: Zorlu
authors.forename: Izzet
authors.initials: I
authors.lastname: Tandoğan
mesh_terms: D002097:C-Reactive Protein / Q000378:metabolism; D015331:Cohort Studies; D003097:Collateral Circulation; D003324:Coronary Artery Disease / Q000097:blood / Q000503:physiopathology*; D005260:Female; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D012044:Regression Analysis; D012189:Retrospective Studies; D012307:Risk Factors; D012720:Severity of Illness Index
chemical_list: D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D002097:C-Reactive Protein