title: Molecular detection of HPV and Chlamydia trachomatis infections in Brazilian women with abnormal cervical cytology.
abstract: The question of whether Chlamydia trachomatis (Ct) is a cofactor for human Papillomavirus (HPV) in cervical carcinogenesis is still controversial. We conducted a molecular detection study of both infections in 622 Brazilian women, including 252 women with different grades of abnormal cervical cytology and cervical cancer (CC; cases) and 370 women with normal cytology (controls). Although Ct infection did not seem related to CC carcinogenicity, women with abnormal cytology had a significant high rate of Ct infection. Therefore, it is important to adopt protocols for diagnosis and treatment of this bacterium in conjunction with screening for CC in this population.
authors.affiliation: Departments of Clinical Analysis and Biomedicine, Medicine, and Basic Science of Health, Universidade Estadual de Maringá, Maringá, Paraná, Brazil. andreluelsdorf@gmail.com
authors.forename: André L P
authors.initials: AL
authors.lastname: de Abreu
authors.forename: Paula R B
authors.initials: PR
authors.lastname: Nogara
authors.forename: Raquel P
authors.initials: RP
authors.lastname: Souza
authors.forename: Mariana C
authors.initials: MC
authors.lastname: da Silva
authors.forename: Nelson S
authors.initials: NS
authors.lastname: Uchimura
authors.forename: Rodrigo L
authors.initials: RL
authors.lastname: Zanko
authors.forename: Erika C
authors.initials: EC
authors.lastname: Ferreira
authors.forename: Maria C B
authors.initials: MC
authors.lastname: Tognim
authors.forename: Jorge J V
authors.initials: JJ
authors.lastname: Teixeira
authors.forename: Fabrícia
authors.initials: F
authors.lastname: Gimenes
authors.forename: Marcia E L
authors.initials: ME
authors.lastname: Consolaro
mesh_terms: D000328:Adult; D052685:Alphapapillomavirus / Q000302:isolation & purification*; D002690:Chlamydia Infections / Q000150:complications* / Q000473:pathology*; D002692:Chlamydia trachomatis; D004279:DNA, Viral / Q000235:genetics; D005260:Female; D005838:Genotype; D006801:Humans; D008875:Middle Aged; D016017:Odds Ratio; D002578:Uterine Cervical Dysplasia / Q000453:epidemiology* / Q000382:microbiology*; D055815:Young Adult
chemical_list: D004279:DNA, Viral