title: APE1 Asp148Glu gene polymorphism and bladder cancer risk: a meta-analysis.
abstract: Published data regarding the association between the apurinic/apyrimidinic endonuclease 1 (APE1) Asp148Glu polymorphism and bladder cancer risk showed inconclusive results. This meta-analysis of literatures was performed to draw a more precise estimation of the relationship. We systematically searched PubMed, Embase, Elsevier and Springer for relevant articles with a time limit of Jan. 2012. The strength of association between APE1 Asp148Glu polymorphism and bladder cancer risk was assessed by odds ratio (OR) with the corresponding 95 % confidence interval (95 % CI) using the software STATA(version10.0).A total of 11 case-control studies including 4,292 cases and 4,761 controls based on the search criteria were included for analysis. Overall, for GG versus TT, the pooled OR was 0.952 (95 % CI = 0.778-1.166), for the the G allele carriers (TG + GG) versus homozygote TT, the pooled OR was 0.984 (95 % CI = 0.897-1.078). In the stratified analysis by ethnicity, significantly risks were not found among Asians for GG versus TT (OR = 0.469; 95 % CI = 0.162-1.357) nor (TG + GG) versus TT (OR = 0.921, 95 % CI = 0.742-1.143). Similarly, for non-Asians, significantly risks were also not found for GG versus TT (OR = 0.992; 95 % CI = 0.861-1.144) nor (TG + GG) versus TT (OR = 1.010, 95 % CI = 0.897-1.137). This meta-analysis suggested that the APE1 T1349G (Asp148Glu) polymorphism was not associated with bladder cancer risk among Asians nor non-Asians.
authors.affiliation: Department of Oncology, Changhai Hospital, Second Military Medical University, Changhai Hospital, 168 Changhai Road, Shanghai, People's Republic of China. chuanliu2005@163.com
authors.forename: Chuan
authors.initials: C
authors.lastname: Liu
authors.forename: Qinghua
authors.initials: Q
authors.lastname: Yin
authors.forename: Lian
authors.initials: L
authors.lastname: Li
authors.forename: Ying-Zhi
authors.initials: YZ
authors.lastname: Zhuang
authors.forename: Xuyu
authors.initials: X
authors.lastname: Zu
authors.forename: Yajie
authors.initials: Y
authors.lastname: Wang
mesh_terms: D000483:Alleles; D016022:Case-Control Studies; D003062:Codon; D043603:DNA-(Apurinic or Apyrimidinic Site) Lyase / Q000235:genetics*; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D016017:Odds Ratio; D020641:Polymorphism, Single Nucleotide; D017594:Publication Bias; D012306:Risk; D001749:Urinary Bladder Neoplasms / Q000235:genetics*
chemical_list: D003062:Codon; C085108:APEX1 protein, human; D043603:DNA-(Apurinic or Apyrimidinic Site) Lyase