title: On the polymorphism of griseofulvin: identification of two additional polymorphs.
abstract: In this paper, we present an investigation of the polymorphism of griseofulvin. In addition to the only reported crystalline form (form I), two new polymorphic forms (II and III) have been identified and characterized by differential scanning calorimetry and powder X-ray diffraction. Reasons why these two polymorphs were isolated during the present study, but not detected during the numerous previous studies on this drug, are also discussed.
authors.affiliation: Univ Lille Nord de France, USTL UMET (Unité Matériaux et Transformations), UMR CNRS 8207, F-59650 Villeneuve d'Ascq, France.
authors.forename: Aurelien
authors.initials: A
authors.lastname: Mahieu
authors.forename: Jean-Francois
authors.initials: JF
authors.lastname: Willart
authors.forename: Emeline
authors.initials: E
authors.lastname: Dudognon
authors.forename: Mark D
authors.initials: MD
authors.lastname: Eddleston
authors.forename: William
authors.initials: W
authors.lastname: Jones
authors.forename: Florence
authors.initials: F
authors.lastname: Danède
authors.forename: Marc
authors.initials: M
authors.lastname: Descamps
mesh_terms: D002152:Calorimetry, Differential Scanning / Q000379:methods; D003460:Crystallization; D006118:Griseofulvin / Q000032:analysis / Q000737:chemistry*; D014961:X-Ray Diffraction / Q000379:methods*
chemical_list: D006118:Griseofulvin