title: Fenton-like degradation of nalidixic acid with Fe(3+)/H2O 2.
abstract: The Fenton-like degradation of nalidixic acid was studied in this work. The effects of Fe(3+) concentration and initial H(2)O(2) concentration were investigated. Increasing the initial H(2)O(2) concentration enhances the degradation and mineralization efficiency for nalidixic acid, while Fe(3+) shows an optimal concentration of 0.25 mM. A complete removal of nalidixic acid and a TOC removal of 28 % were achieved in 60 min under a reaction condition of [Fe(3+)] =0.25 mM, [H(2)O(2)] =10 mM, T=35 °C, and pH=3. LC-MS analysis technique was used to analyze the possible degradation intermediates. The degradation pathways of nalidixic acid were proposed according to the identified intermediates and the electron density distribution of nalidixic acid. The Fenton-like degradation reaction of nalidixic acid mainly begins with the electrophilic attack of hydroxyl radical towards the C3 position which results in the ring-opening reaction; meanwhile, hydroxyl radical attacking to the branched alkyl groups of nalidixic acid leads to the oxidation at the branched alkyl groups.
authors.affiliation: Key Laboratory for Advanced Materials and Institute of Fine Chemicals, East China University of Science and Technology, Shanghai, 200237, People's Republic of China. fxq5566@163.com
authors.forename: Xiangqun
authors.initials: X
authors.lastname: Fan
authors.forename: Hongyuan
authors.initials: H
authors.lastname: Hao
authors.forename: Yongchuan
authors.initials: Y
authors.lastname: Wang
authors.forename: Feng
authors.initials: F
authors.lastname: Chen
authors.forename: Jinlong
authors.initials: J
authors.lastname: Zhang
mesh_terms: D002853:Chromatography, Liquid; D006861:Hydrogen Peroxide / Q000378:metabolism*; D017665:Hydroxyl Radical / Q000378:metabolism; D007501:Iron / Q000032:analysis / Q000378:metabolism*; D013058:Mass Spectrometry; D019216:Metals, Heavy / Q000302:isolation & purification / Q000378:metabolism; D009268:Nalidixic Acid / Q000378:metabolism*; D010084:Oxidation-Reduction; D062065:Wastewater / Q000737:chemistry
chemical_list: D006861:Hydrogen Peroxide; D017665:Hydroxyl Radical; D007501:Iron; D019216:Metals, Heavy; D009268:Nalidixic Acid; D062065:Wastewater