title: Design, synthesis and structure-activity relationship of novel insecticidal dichloro-allyloxy-phenol derivatives containing substituted pyrazol-3-ols.
abstract: BACKGROUND
  Pyridalyl, consisting of dicholoro-allyoxy-phenol moiety, is a novel class of insecticide showing extraordinary activities against various lepidopterous and thysanopterous pests on cotton and vegetables. To discover further novel insecticides, a series of new dichloro-allyloxy-phenol derivatives containing substituted pyrazol-3-ol moieties were designed and synthesised via the intermediate derivatisation method.
  
  
  RESULTS
  The target compounds were characterised by (1) H NMR, IR, MS and elemental analysis. Bioassays indicated that some of these compounds exhibited good insecticidal activities against diamondback moth (Plutella xylostella) at 6.25 mg L(-1) . The structure-activity relationship is discussed.
  
  
  CONCLUSIONS
  The present work demonstrates that dichloro-allyloxy-phenol derivatives with substituted phenylpyrazole moieties can be used as lead compounds to develop further novel insecticides.
authors.affiliation: State Key Laboratory of the Discovery and Development of Novel Pesticide, Shenyang Research Institute of Chemical Industry Co. Ltd, Shenyang, China.
authors.forename: Miao
authors.initials: M
authors.lastname: Li
authors.forename: Chang-Ling
authors.initials: CL
authors.lastname: Liu
authors.forename: Jing
authors.initials: J
authors.lastname: Zhang
authors.forename: Qiao
authors.initials: Q
authors.lastname: Wu
authors.forename: Shu-Lin
authors.initials: SL
authors.lastname: Hao
authors.forename: Yu-quan
authors.initials: YQ
authors.lastname: Song
mesh_terms: D015195:Drug Design; D007306:Insecticides / Q000737:chemistry*; D010647:Phenyl Ethers / Q000737:chemistry*; D013329:Structure-Activity Relationship
chemical_list: D007306:Insecticides; D010647:Phenyl Ethers; C418569:S 1812