title: Anesthetic effects on susceptibility to cortical spreading depression.
abstract: Cortical spreading depression (CSD) is a transient neuronal and glial depolarization and disruption of membrane ionic gradients that propagates slowly across the cerebral cortex. Recent clinical and experimental evidence has implicated CSD in the pathophysiology of migraines and neuronal injury states. In the current study, we examined the influence of four different anesthetics (propofol, dexmedetomidine, isoflurane, pentobarbital) on CSD susceptibility in a KCl application animal model. We found that isoflurane and dexmedetomidine suppressed CSD frequency, and tended to reduce the CSD propagation speed. Our data suggest that these anesthetics may be therapeutically beneficial in preventing CSD in diverse neuronal injury states.
authors.affiliation: Department of Dental Anesthesiology, Osaka University Graduate School of Dentistry, 1-8 Yamadaoka, Suita, Osaka 565-0871, Japan. ckudo@dent.osaka-u.ac.jp
authors.forename: Chiho
authors.initials: C
authors.lastname: Kudo
authors.forename: Midori
authors.initials: M
authors.lastname: Toyama
authors.forename: Aiji
authors.initials: A
authors.lastname: Boku
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Hanamoto
authors.forename: Yoshinari
authors.initials: Y
authors.lastname: Morimoto
authors.forename: Mitsutaka
authors.initials: M
authors.lastname: Sugimura
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Niwa
mesh_terms: D000777:Anesthetics / Q000494:pharmacology*; D000818:Animals; D013181:Cortical Spreading Depression / Q000187:drug effects* / Q000502:physiology*; D020927:Dexmedetomidine / Q000494:pharmacology; D007530:Isoflurane / Q000494:pharmacology; D008297:Male; D010424:Pentobarbital / Q000494:pharmacology; D015742:Propofol / Q000494:pharmacology; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D000777:Anesthetics; D020927:Dexmedetomidine; D007530:Isoflurane; D010424:Pentobarbital; D015742:Propofol