title: MRP2 (ABCC2, cMOAT) expression in nuclear envelope of primary fallopian tube cancer cells is a new unfavorable prognostic factor.
abstract: OBJECTIVE
  To determine the prognostic value of the immunohistochemical evaluation of the multidrug resistance-associated protein 2 (MRP2) expression, together with its subcellular localization in primary fallopian tube carcinomas (PFTCs).
  
  
  METHODS
  The immunohistochemical analysis was performed using samples originating from 70 patients with PFTCs.
  
  
  RESULTS
  (1) We documented that MRP2 can be localized in the plasma membrane (MRP2c), as well as in the nuclear envelope (MRP2n) of the PFTC cells. (2) Patients with more advanced stage, with progression of the disease and patients who died, showed significantly higher expression of the MRP2n. (3) Univariate and multivariate analyses showed that MRP2n is an unfavorable prognostic factor in PFTCs. (4) The analysis of the classic clinicopathological data revealed that only the FIGO stage had prognostic value, both in the univariate, as well as in multivariate analysis.
  
  
  CONCLUSIONS
  (1) This study suggests that MRP2n is a new disadvantageous prognostic factor in PFTCs and (2) that expression in nuclear envelope can be associated with lower differentiation of cancer cells and their resistance to the cisplatin. (3) We have also confirmed independent prognostic value of FIGO stage in PFTCs.
authors.affiliation: Department of Pathomorphology and Oncological Cytology, Wroclaw Medical University, ul. Borowska 213, 50-556 Wroclaw, Poland. ahalon2@gmail.com
authors.forename: Agnieszka
authors.initials: A
authors.lastname: Halon
authors.forename: Verena
authors.initials: V
authors.lastname: Materna
authors.forename: Piotr
authors.initials: P
authors.lastname: Donizy
authors.forename: Rafal
authors.initials: R
authors.lastname: Matkowski
authors.forename: Jerzy
authors.initials: J
authors.lastname: Rabczynski
authors.forename: Hermann
authors.initials: H
authors.lastname: Lage
authors.forename: Pawel
authors.initials: P
authors.lastname: Surowiak
mesh_terms: D018262:Adenocarcinoma, Clear Cell / Q000175:diagnosis / Q000378:metabolism; D002277:Carcinoma / Q000175:diagnosis / Q000378:metabolism*; D018269:Carcinoma, Endometrioid / Q000175:diagnosis / Q000378:metabolism; D002295:Carcinoma, Transitional Cell / Q000175:diagnosis / Q000378:metabolism; D019008:Drug Resistance, Neoplasm; D005185:Fallopian Tube Neoplasms / Q000175:diagnosis / Q000378:metabolism*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008875:Middle Aged; D000089762:Multidrug Resistance-Associated Protein 2; D027425:ATP-Binding Cassette, Sub-Family C Proteins / Q000378:metabolism*; D009363:Neoplasm Proteins / Q000378:metabolism*; D009685:Nuclear Envelope / Q000378:metabolism*; D011379:Prognosis; D012189:Retrospective Studies
chemical_list: D000089762:Multidrug Resistance-Associated Protein 2; D027425:ATP-Binding Cassette, Sub-Family C Proteins; D009363:Neoplasm Proteins; C000715087:ABCC2 protein, human