title: N-heterocyclic carbene-catalyzed [4 + 2] cycloaddition of ketenes and 3-aroylcoumarins: highly enantioselective synthesis of dihydrocoumarin-fused dihydropyranones.
abstract: The N-heterocyclic carbene-catalyzed [4 + 2] cyclization of ketenes and 3-aroylcoumarins has been developed to give the corresponding dihydrocoumarin-fused multisubstituted dihydropyranones in high yield with good diastereoselectivity and high enantioselectivity.
authors.affiliation: Beijing National Laboratory for Molecular Sciences, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China.
authors.forename: Teng-Yue
authors.initials: TY
authors.lastname: Jian
authors.forename: Xiang-Yu
authors.initials: XY
authors.lastname: Chen
authors.forename: Li-Hui
authors.initials: LH
authors.lastname: Sun
authors.forename: Song
authors.initials: S
authors.lastname: Ye
mesh_terms: D002384:Catalysis; D003374:Coumarins / Q000737:chemistry*; D018360:Crystallography, X-Ray; D003500:Cyclization; D005030:Ethylenes / Q000737:chemistry*; D006571:Heterocyclic Compounds / Q000737:chemistry*; D007659:Ketones / Q000737:chemistry*; D008697:Methane / Q000031:analogs & derivatives* / Q000737:chemistry; D008958:Models, Molecular; D015394:Molecular Structure; D011753:Pyrones / Q000138:chemical synthesis* / Q000737:chemistry; D013237:Stereoisomerism
chemical_list: D003374:Coumarins; D005030:Ethylenes; D006571:Heterocyclic Compounds; D007659:Ketones; D011753:Pyrones; C030011:carbene; C008223:ketene; D008697:Methane