title: Bullous Pemphigoid Accompanied by Aplastic Anemia: The Induction of IL-17-Producing Cells in the Affected Areas of the Skin.
abstract: Th17 cells, characterized by IL-17 production, play a critical role in the pathogenesis of autoimmune diseases, including autoimmune bullous disorders and aplastic anemia (AA). In this report, we describe a 58-year-old Japanese man with bullous pemphigoid (BP) accompanied by AA. Interestingly, immunohistochemical staining revealed the existence of IL-17-producing cells in the skin biopsy specimens from BP. Our findings might suggest relationships between IL-17 and the pathogenesis of these autoimmune diseases, and, to our knowledge, this is the first English report of BP accompanied by AA.
authors.affiliation: Department of Dermatology, Tohoku University Graduate School of Medicine, Sendai, Japan.
authors.forename: Taku
authors.initials: T
authors.lastname: Fujimura
authors.forename: Aya
authors.initials: A
authors.lastname: Kakizaki
authors.forename: Yumi
authors.initials: Y
authors.lastname: Kambayashi
authors.forename: Sadanori
authors.initials: S
authors.lastname: Furudate
authors.forename: Setsuya
authors.initials: S
authors.lastname: Aiba
keywords: Aplastic anemia; Bullous pemphigoid; IL-17