title: Ivermectin inhibits growth of Chlamydia trachomatis in epithelial cells.
abstract: Ivermectin is currently approved for treatment of both clinical and veterinary infections by nematodes, including Onchocerca cervicalis in horses and Onchocerca volvulus in humans. However, ivermectin has never been shown to be effective against bacterial pathogens. Here we show that ivermectin also inhibits infection of epithelial cells by the bacterial pathogen, Chlamydia trachomatis, at doses that could be envisioned clinically for sexually-transmitted or ocular infections by Chlamydia.
authors.affiliation: Molecular Cell Biology, Health Sciences Research Institute, University of California Merced, United States of America.
authors.forename: Matthew A
authors.initials: MA
authors.lastname: Pettengill
authors.forename: Verissa W
authors.initials: VW
authors.lastname: Lam
authors.forename: Ikechukwu
authors.initials: I
authors.lastname: Ollawa
authors.forename: Camila
authors.initials: C
authors.lastname: Marques-da-Silva
authors.forename: David M
authors.initials: DM
authors.lastname: Ojcius
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D002692:Chlamydia trachomatis / Q000187:drug effects* / Q000502:physiology; D004847:Epithelial Cells / Q000382:microbiology*; D006367:HeLa Cells; D006801:Humans; D007559:Ivermectin / Q000494:pharmacology*
chemical_list: D000900:Anti-Bacterial Agents; D007559:Ivermectin