title: [Meta analysis of association between TNF-α-308 polymorphism and periodontitis in Chinese Han population].
abstract: OBJECTIVE
  To assess the association between TNF-α-308 polymorphism and periodontitis in Chinese Han population.
  
  
  METHODS
  Articles published between 1994 and 2011 were searched in the fulltext database of CNKI, Chinese Biomedical Literature Database, Wanfang Database and PubMed. Case-control studies on TNF-α-308 polymorphism and periodontitis were searched up to Feb.,2011, including articles in Chinese and in English. Meta analysis was performed to evaluate the prevalence of Allele 2 between case group and control group.
  
  
  RESULTS
  Five studies were entered into Meta analysis,with 494 cases and 501 controls . No significant heterogeneity was found among the studies(P=0.38); the pooled OR value of allele 2 was 2.12(95% CI 1.57-2.86), with significant difference(P<0.01).
  
  
  CONCLUSIONS
  Meta analysis showed that TNF-α-308 polymorphism was associated with periodontitis in Chinese Han population.
authors.affiliation: Department of Periodontology, Guangdong Provincial Stomatological Hospital & Affiliated Hospital of Southern Medical University, Guangzhou 510280, Guangdong Province, China. chengjie.xie@gmail.com
authors.forename: Cheng-jie
authors.initials: CJ
authors.lastname: Xie
authors.forename: Lei
authors.initials: L
authors.lastname: Chen
authors.forename: Fang-li
authors.initials: FL
authors.lastname: Tong
authors.forename: Li-min
authors.initials: LM
authors.lastname: Xiao
authors.forename: Jin-cai
authors.initials: JC
authors.lastname: Zhang
mesh_terms: D000483:Alleles; D044466:Asian People; D016022:Case-Control Studies; D005006:Ethnicity; D006801:Humans; D010518:Periodontitis; D011110:Polymorphism, Genetic; D014409:Tumor Necrosis Factor-alpha
chemical_list: D014409:Tumor Necrosis Factor-alpha