title: The prevalence of human cytomegalovirus DNA in gliomas of Brazilian patients.
abstract: Members of the Herpesviridae family have been implicated in a number of tumours in humans. At least 75% of the human population has had contact with cytomegalovirus (HCMV). In this work, we screened 75 Brazilian glioma biopsies for the presence of HCMV DNA sequences. HCMV DNA was detected in 36% (27/75) of the biopsies. It is possible that HCMV could be a co-factor in the evolution of brain tumours.
authors.affiliation: Laboratório de Controle da Expressão Gênica, Instituto de Biofísica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Brasil.
authors.forename: Renata Fragelli
authors.initials: RF
authors.lastname: Fonseca
authors.forename: Marcia Tie
authors.initials: MT
authors.lastname: Kawamura
authors.forename: José Antônio
authors.initials: JA
authors.lastname: Oliveira
authors.forename: Anselmo
authors.initials: A
authors.lastname: Teixeira
authors.forename: Gilda
authors.initials: G
authors.lastname: Alves
authors.forename: Maria da Glória da Costa
authors.initials: Mda G
authors.lastname: Carvalho
mesh_terms: D000328:Adult; D001706:Biopsy; D001932:Brain Neoplasms / Q000821:virology*; D002648:Child; D015331:Cohort Studies; D003587:Cytomegalovirus / Q000235:genetics* / Q000276:immunology; D003586:Cytomegalovirus Infections / Q000150:complications* / Q000175:diagnosis; D004279:DNA, Viral / Q000032:analysis*; D005260:Female; D005910:Glioma / Q000821:virology*; D006801:Humans; D017874:Immediate-Early Proteins / Q000032:analysis / Q000276:immunology; D008297:Male; D009367:Neoplasm Staging; D016133:Polymerase Chain Reaction; D015995:Prevalence; D055815:Young Adult
chemical_list: D004279:DNA, Viral; C088645:IE1 protein, cytomegalovirus; D017874:Immediate-Early Proteins