title: Formulations for trans-tympanic antibiotic delivery.
abstract: We have developed a drug delivery system for prolonged trans-tympanic antibiotic delivery from a single dose administration. Increased permeability to ciprofloxacin of the intact tympanic membrane (TM) was achieved by chemical permeation enhancers (CPEs--bupivacaine, limonene, sodium dodecyl sulfate); this was also seen by CPEs contained within a hydrogel (poloxamer 407) to maintain the formulation at the TM. The CPE-hydrogel formulation had minimal effects on auditory thresholds and tissue response in vivo. CPE-hydrogel formulations have potential for ototopical delivery of ciprofloxacin for the treatment of acute otitis media (AOM) and other middle ear diseases.
authors.affiliation: Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
authors.forename: Xiaojuan
authors.initials: X
authors.lastname: Khoo
authors.forename: Emmanuel J
authors.initials: EJ
authors.lastname: Simons
authors.forename: Homer H
authors.initials: HH
authors.lastname: Chiang
authors.forename: Julia M
authors.initials: JM
authors.lastname: Hickey
authors.forename: Vishakha
authors.initials: V
authors.lastname: Sabharwal
authors.forename: Stephen I
authors.initials: SI
authors.lastname: Pelton
authors.forename: John J
authors.initials: JJ
authors.lastname: Rosowski
authors.forename: Robert
authors.initials: R
authors.lastname: Langer
authors.forename: Daniel S
authors.initials: DS
authors.lastname: Kohane
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000008:administration & dosage* / Q000493:pharmacokinetics*; D002682:Chinchilla; D002939:Ciprofloxacin / Q000008:administration & dosage* / Q000737:chemistry / Q000493:pharmacokinetics*; D004339:Drug Compounding / Q000379:methods; D008297:Male; D053769:Nanocapsules / Q000008:administration & dosage* / Q000737:chemistry; D010033:Otitis Media / Q000188:drug therapy*; D014432:Tympanic Membrane / Q000378:metabolism*
chemical_list: D000900:Anti-Bacterial Agents; D053769:Nanocapsules; D002939:Ciprofloxacin