title: A comparative study between 0.5% centbucridine HCl and 2% lignocaine HCl with adrenaline (1:2,00,000).
abstract: Even today the ability to provide the patient with clinically adequate pain control with minimum systemic side effects is one of the major concerns all over the world. Lignocaine, the most commonly used local anesthetic agent in oral surgery due to its rapid onset & reasonably good potency, does not have adequate duration of action, unless used with Adrenaline, a drug known for its cardiovascular effects. Centbucridine, a non-ester, non-amide group local anesthetic agent developed in India at C D R I Lucknow, has advantage of inherent vasoconstrictor property. This study was planned to compare 0.5% Centbucridine and 2% Lignocaine with Adrenaline, in exodontia patients. The results were recorded for their efficacy and C V S action and statistically analyzed. Centbucridine was found to be an ideal local anesthetic agent with no effects on cardiovascular parameters and exhibiting a sufficient degree of local anesthetic activity suitable for use in routine minor surgery cases. This will be advantageous where Adrenaline is absolutely contraindicated due to systemic problems.
authors.affiliation: Dept. of Oral and Maxillofacial Surgery, Bharati Vidyapeeth University Dental College and Hospital, Pune, India  ; Dept. of Oral and Maxillofacial Surgery, B.V. University Dental College and Hospital, Katraj, Pune, 411043 Maharashtra India.
authors.forename: Arun
authors.initials: A
authors.lastname: Dugal
authors.forename: Ritika
authors.initials: R
authors.lastname: Khanna
authors.forename: Amod
authors.initials: A
authors.lastname: Patankar
keywords: Centbucridine; Lignocaine; Local anaesthetic