title: A histomorphometric study of cellular layers after hemiepiphyseal stapling on the physeal plate in rabbits.
abstract: BACKGROUND
  Epiphyseal stapling has been widely used to correct angular deformity. The mechanism, however, has not been well determined. To determine the effect of temporary hemiepiphyseal stapling on the cellular layers of the physis, a histomorphometric study was performed using immature rabbits.
  
  
  METHODS
  Distal lateral epiphyseal stapling of the right femur was performed on 6-week-old New Zealand white rabbits. Thirty rabbits were randomly assigned to five groups, and six rabbits in each group were analyzed weekly for up to 5 weeks.
  
  
  RESULTS
  The distal femur was deformed into the valgus, and the anatomical lateral distal femoral angle decreased with the passage of time. In the sequential histomorphometry of the operated physeal plate, the area ratio of each layer, compared to the control side, decreased every week. The total area of the physeal plate had decreased up to 60 % at the 5th week compared to the area of the 1st week, and the area of the proliferative layer decreased by the greatest amount among the three layers.
  
  
  CONCLUSIONS
  Our findings suggest that the proliferation of chondrocytes seemed to be more suppressed by the compression of the stapling, thereby slowing the growth rate, although hypertrophy of the chondrocytes was also suppressed.
authors.affiliation: Good-morning Hospital, 972, Dal-dong, Nam-gu, Ulsan 680-804, Korea.
authors.forename: Su-Min
authors.initials: SM
authors.lastname: Son
authors.forename: Il-Hyung
authors.initials: IH
authors.lastname: Park
authors.forename: Chang-Wug
authors.initials: CW
authors.lastname: Oh
authors.forename: Hyun-Joo
authors.initials: HJ
authors.lastname: Lee
authors.forename: Byung-Chul
authors.initials: BC
authors.lastname: Park
authors.forename: Je-Yong
authors.initials: JY
authors.lastname: Choi
mesh_terms: D000818:Animals; D019902:Chondrocytes / Q000473:pathology; D004195:Disease Models, Animal; D005269:Femur / Q000601:surgery*; D006132:Growth Plate / Q000473:pathology* / Q000601:surgery; D007870:Leg Length Inequality / Q000473:pathology / Q000601:surgery*; D008297:Male; D019637:Orthopedic Procedures / Q000379:methods*; D011817:Rabbits; D017792:Surgical Stapling