title: Intraoperative fluid management and complications following pancreatectomy.
abstract: BACKGROUND
  Considerable debate exists as to appropriate perioperative fluid management. Data from several studies suggest that the amount of fluid administered perioperatively influences surgical outcome. Pancreatic resection is a major procedure in which complications are common. We examined 1,030 sequential patients who had undergone pancreatic resection at Memorial Sloan-Kettering Cancer Center. We documented the prevalence and nature of their complications, and then correlated complications to intraoperative fluid administration.
  
  
  METHODS
  We retrospectively examined 1,030 pancreatic resections performed at Memorial Sloan-Kettering Cancer Center between May 2004 and December 2009 from our pancreatic database. Intraoperative administration of colloid and crystalloid was obtained from anesthesia records, and complication data from our institutional database.
  
  
  RESULTS
  The overall in-hospital mortality was 1.7%. Operative mortality was due predominantly to intraabdominal infection. Sixty percent of the mortality resulted from intraabdominal complications related to the procedure. We did not demonstrate a clinically significant relationship between intraoperative fluid administration and complications, although minor statistical significance was suggested.
  
  
  CONCLUSIONS
  In this retrospective review of intraoperative fluid administration we were not able to demonstrate a clinically significant association between postoperative complications and intraoperative crystalloid and colloid fluid administration. A randomized controlled trial has been initiated to address this question.
authors.affiliation: Department of Anesthesiology and Critical Care Medicine, Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA. grantf@mskcc.org
authors.forename: Florence M
authors.initials: FM
authors.lastname: Grant
authors.forename: Mladjan
authors.initials: M
authors.lastname: Protic
authors.forename: Mithat
authors.initials: M
authors.lastname: Gonen
authors.forename: Peter
authors.initials: P
authors.lastname: Allen
authors.forename: Murray F
authors.initials: MF
authors.lastname: Brennan
mesh_terms: D000230:Adenocarcinoma / Q000601:surgery; D016063:Blood Loss, Surgical; D003102:Colloids / Q000008:administration & dosage*; D000077324:Crystalloid Solutions; D005440:Fluid Therapy; D006439:Hemodynamics / Q000502:physiology; D017052:Hospital Mortality; D006801:Humans; D007430:Intraoperative Care; D007552:Isotonic Solutions / Q000008:administration & dosage*; D007902:Length of Stay; D061646:Operative Time; D010180:Pancreatectomy; D010190:Pancreatic Neoplasms / Q000601:surgery; D011183:Postoperative Complications; D012189:Retrospective Studies
chemical_list: D003102:Colloids; D000077324:Crystalloid Solutions; D007552:Isotonic Solutions