title: Isoconazole nitrate vs isoconazole nitrate and diflucortolone valerate in the treatment of tinea inguinalis: results of a multicenter retrospective study.
abstract: OBJECTIVE
  Many tinea inguinalis infections are characterized by pronounced inflammatory lesions and pruritus. Therefore, a therapy with a topical corticosteroid in addition to a topical antimycotic agent might be beneficial. In this multicenter, retrospective study, we compared the mycological and clinical efficacy and tolerability of isoconazole nitrate alone vs isoconazole nitrate and diflucortolone valerate in 58 adult patients with tinea inguinalis.
  
  
  METHODS
  Treatment duration was three weeks. The efficacy of the treatment was based on the assessment of several signs and symptoms, which were collected on a 4-point scale. All patients were examined clinically before the beginning of the treatment, one week later, two weeks later, and at the end of the treatment. Mycological examinations were performed before the beginning of the treatment and at the end of the study.
  
  
  RESULTS
  Treatment results with the combination of isoconazole nitrate and diflucortolone valerate were superior regarding erythema and pruritus. Both erythema and pruritus resolved in a larger percentage of patients and more quickly. Both regimens were well tolerated. Mycological cure rates were similar in both groups of patients.
  
  
  CONCLUSIONS
  Combination therapy with isoconazole nitrate and diflucortolone valerate is an effective and well-tolerated regimen in adult patients with tinea inguinalis.
authors.affiliation: Department of Anesthesiology, Intensive Care and Dermatological Sciences, Università degli Studi di Milano, Fondazione IRCCS Ca'Granda-Ospedale Maggiore Policlinico, Milan, Italy. stefano.veraldi@unimi.it
authors.forename: Stefano
authors.initials: S
authors.lastname: Veraldi
authors.forename: Maria Chiara
authors.initials: MC
authors.lastname: Persico
authors.forename: Rossana
authors.initials: R
authors.lastname: Schianchi
mesh_terms: D000279:Administration, Cutaneous; D000293:Adolescent; D000328:Adult; D000935:Antifungal Agents / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D004060:Diflucortolone / Q000008:administration & dosage / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000627:therapeutic use; D004359:Drug Therapy, Combination; D004890:Erythema / Q000188:drug therapy / Q000382:microbiology; D006801:Humans; D008297:Male; D008825:Miconazole / Q000008:administration & dosage / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000627:therapeutic use; D008875:Middle Aged; D011537:Pruritus / Q000188:drug therapy / Q000382:microbiology; D012189:Retrospective Studies; D013997:Time Factors; D014005:Tinea / Q000188:drug therapy* / Q000382:microbiology; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D000935:Antifungal Agents; C013486:diflucortolone valerate; D008825:Miconazole; C020382:isoconazole; D004060:Diflucortolone