title: Mixed-type multicentric Castleman's disease developing during a 17-year follow-up of sarcoidosis.
abstract: Multicentric Castleman's Disease (MCD) is a systemic disease characterized by generalized lymphadenopathy and the proliferation of plasma cells. The development of MCD in a patient with preexisting sarcoidosis has not been previously reported. We herein describe a case of MCD developing in a 78-year-old woman with a 17-year history of sarcoidosis. The patient's serum interleukin-6 (IL-6) levels were only slightly elevated; however, the IL-6 levels in the fluid of both pleural effusion and ascites were markedly elevated. The administration of steroid-pulse therapy and prednisolone was ineffective in treating the MCD, although treatment with tocilizumab proved highly effective.
authors.affiliation: Department of Respiratory Medicine, Japanese Red Cross Medical Center, Japan. awanobu0606@hotmail.co.jp
authors.forename: Nobuyasu
authors.initials: N
authors.lastname: Awano
authors.forename: Minoru
authors.initials: M
authors.lastname: Inomata
authors.forename: Keisuke
authors.initials: K
authors.lastname: Kondoh
authors.forename: Kohta
authors.initials: K
authors.lastname: Satake
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Kamiya
authors.forename: Atsuko
authors.initials: A
authors.lastname: Moriya
authors.forename: Tsunehiro
authors.initials: T
authors.lastname: Ando
authors.forename: Toshio
authors.initials: T
authors.lastname: Kumasaka
authors.forename: Tamiko
authors.initials: T
authors.lastname: Takemura
authors.forename: Kengo
authors.initials: K
authors.lastname: Takeuchi
authors.forename: Soichiro
authors.initials: S
authors.lastname: Ikushima
mesh_terms: D000328:Adult; D061067:Antibodies, Monoclonal, Humanized / Q000627:therapeutic use; D001201:Ascites / Q000276:immunology; D005871:Castleman Disease / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy / Q000276:immunology; D005260:Female; D006801:Humans; D015850:Interleukin-6 / Q000097:blood / Q000378:metabolism; D010996:Pleural Effusion / Q000276:immunology; D012507:Sarcoidosis / Q000150:complications*; D013997:Time Factors
chemical_list: D061067:Antibodies, Monoclonal, Humanized; C508600:IL6 protein, human; D015850:Interleukin-6; C502936:tocilizumab