title: Corneal thickness and volume in subclinical and clinical keratoconus.
abstract: To evaluate corneal thickness and volume in subclinical and clinical keratoconus in Asian population with the aim of discriminating between normal and ectatic cornea. Eyes were placed into one of the following three groups: normal, subclinical, and mild-moderate keratoconus. Pentacam Scheimpflug imaging (Oculus Inc., Wetzlar, Germany) was performed for each participant to record thinnest corneal thickness, central corneal thickness, corneal volume (CV), peripheral corneal thickness (PCT) and percentage thickness increase (PTI) at 2, 4, 6, and 8 mm. The data were exported to SPSS for statistical analysis. Subjects comprised 52 normal, 15 subclinical keratoconus, and 32 mild-moderate clinical keratoconus eyes. Our results indicated that corneal thickness (CT) distribution, PTI, and CV in normal eyes were significantly different compared with subclinical and clinical keratoconus (P < .05). Overall, subclinical group exhibited lower CT distribution and volume, and higher PTI in comparison with normal eyes. However, they showed higher CT distribution and volume, and lower PTI compared with keratoconus group. In addition, there was a smaller change in PCT and PTI from the thinnest point of the cornea to the periphery. The results of the present study indicate that CT parameters and CV were significantly different in normal versus subclinical group and in normal versus keratoconus group. These findings could help clinicians to better discriminate between normal and ectatic cornea.
authors.affiliation: School of Healthcare Sciences, Faculty of Health Sciences, Universiti Kebangsaan Malaysia, Jalan Raja Muda Abdul Aziz, 50300, Kuala Lumpur, Malaysia.
authors.forename: Seyed Mahdi
authors.initials: SM
authors.lastname: Ahmadi Hosseini
authors.forename: Norhani
authors.initials: N
authors.lastname: Mohidin
authors.forename: Fereshteh
authors.initials: F
authors.lastname: Abolbashari
authors.forename: Bariah
authors.initials: B
authors.lastname: Mohd-Ali
authors.forename: Chandramalar T
authors.initials: CT
authors.lastname: Santhirathelagan
mesh_terms: D000293:Adolescent; D000328:Adult; D044466:Asian People / Q000706:statistics & numerical data*; D003315:Cornea / Q000473:pathology*; D019781:Corneal Topography / Q000379:methods; D003430:Cross-Sectional Studies; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D007640:Keratoconus / Q000208:ethnology* / Q000473:pathology*; D008296:Malaysia / Q000453:epidemiology; D008297:Male; D010781:Photography / Q000379:methods; D012189:Retrospective Studies; D055815:Young Adult