title: Roles of phosphoinositides and phosphoinositides kinases in hepatitis C virus RNA replication.
abstract: Phosphoinositides (PIs) play an essential role in mediating key signaling pathways on biological membranes. Hepatitis C virus (HCV) replicates its RNA genome by establishing a viral replication complex (RC) on host cell membranes. Recently, an increasing body of literature reported that not only PIs themselves but also several PIs-specific kinases are required for efficient replication of HCV RNA genome. Especially, PI 4-kinases type III alpha, beta as well as their enzymatic products including phosphatidylinositol 4-phosphate (PI(4)P) and phosphatidylinositol 4,5-bisphosphate (PI(4,5)P(2)) are consistently identified to be host factors essential for HCV replication. In this article, the current state of our knowledge of PIs and PIs-specific kinases together with their roles in modulating HCV replication is reviewed. The effects of various PIs-specific kinases inhibitors on HCV replication are also highlighted, proposing them as promising candidate targets to which a new class of anti-HCV therapeutics can be envisaged.
authors.affiliation: Dongguk University College of Pharmacy, Goyang, Korea. choongholee@dongguk.edu
authors.forename: Choongho
authors.initials: C
authors.lastname: Lee
mesh_terms: D019870:1-Phosphatidylinositol 4-Kinase / Q000037:antagonists & inhibitors / Q000378:metabolism*; D004791:Enzyme Inhibitors / Q000494:pharmacology; D016679:Genome, Viral / Q000187:drug effects; D016174:Hepacivirus / Q000235:genetics / Q000502:physiology*; D006526:Hepatitis C / Q000188:drug therapy / Q000201:enzymology / Q000378:metabolism / Q000821:virology*; D006801:Humans; D010716:Phosphatidylinositols / Q000378:metabolism*; D012367:RNA, Viral / Q000235:genetics*; D014779:Virus Replication / Q000187:drug effects / Q000502:physiology*
chemical_list: D004791:Enzyme Inhibitors; D010716:Phosphatidylinositols; D012367:RNA, Viral; D019870:1-Phosphatidylinositol 4-Kinase