title: Marine natural products and related compounds as anticancer agents: an overview of their clinical status.
abstract: Marine ecosystems constitute a huge reservoir of biologically active secondary metabolites. Consequently during the last past few decades, several marine-derived molecules have been approved for anticancer treatment or are under clinical trials. This review reports the present state of the art of the sixteen molecules approved or currently on the clinical pipeline for anticancer chemotherapy. The molecules are classified according to their current status in the phase (approved / phase IV / phase III / phase II / phase I) and data are updated to April 2012.
authors.affiliation: LUNAM Université, Université de Nantes, MMS, F-44000 Nantes, France. karina.petit@univ-nantes.fr
authors.forename: Karina
authors.initials: K
authors.lastname: Petit
authors.forename: Jean-François
authors.initials: JF
authors.lastname: Biard
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D001688:Biological Products / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D018849:Controlled Clinical Trials as Topic; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D008958:Models, Molecular; D008968:Molecular Conformation; D009369:Neoplasms / Q000188:drug therapy* / Q000473:pathology
chemical_list: D000970:Antineoplastic Agents; D001688:Biological Products