title: [Association of MTHFR C677T and MS A2756G polymorphism with semen quality].
abstract: OBJECTIVE
  To investigate the association of MTHFR C677T and MS A2756G polymorphism with semen quality in China.
  
  
  METHODS
  The experimental group included 75 males with oligospermia, asthenospermia or teratospermia. The control group included 72 fertile males with normal fertility and sperm quality. The differences in the frequency of genetic polymorphism of MTHFR C677T and MS A2756G in the 2 groups were analyzed, and the plasma homocysteine (Hcy) level in both groups was detected.
  
  
  RESULTS
  The frequency of MTHFR C677T genotypes (CT, TT and CT+TT) in the abnormal sperm group was higher than that in the control group (P<0.05), and it was the same case for T allele between the 2 groups (P<0.05). There was no difference in the frequency of MS A2756G genotypes between the two groups (P>0.05). The Hcy level in abnormal sperm group was higher than that in the control group. In all subjects, the Hcy level of the MTHFR genotypes (CT, TT and CT+TT) was higher than that of the CC genotype, with no difference among the three MS A2756G genotypes.
  
  
  CONCLUSIONS
  CT and TT genotypes of MTHFR C677T are associated with abnormal sperm, which might be part of the pathogenesis of abnormal sperms. T allele may be the risk factor in China. The one mechanism of the association between MTHFR C677T polymorphism and semen quality could be higher Hcy level. MS A2756G polymorphism may not associate with semen quality in China.
authors.affiliation: Reproductive Medicine Center of Peking University, Shenzhen, China.
authors.forename: Ling
authors.initials: L
authors.lastname: Liu
authors.forename: Zhiming
authors.initials: Z
authors.lastname: Cai
authors.forename: Huimin
authors.initials: H
authors.lastname: Leng
authors.forename: Weiping
authors.initials: W
authors.lastname: Qian
mesh_terms: D000483:Alleles; D002681:China; D005838:Genotype; D006801:Humans; D008297:Male; D042965:Methylenetetrahydrofolate Reductase (NADPH2) / Q000235:genetics*; D011110:Polymorphism, Genetic; D012307:Risk Factors; D055101:Semen Analysis
chemical_list: C573423:MTHFR protein, human; D042965:Methylenetetrahydrofolate Reductase (NADPH2)