title: Tracking injectable microspheres in dynamic tissues with encapsulated superparamagnetic iron oxide nanoparticles.
abstract: Trackable spheres of similar size to those typically used for sustained protein delivery are prepared by incorporating superparamagnetic iron oxide (SPIO) nanoparticles into the core of poly(lactide-co-glycolide) microspheres. The visibility of injections in static and temporally in dynamic tissue systems is demonstrated. This method improves upon other, less sensitive imaging modalities in their ability to track injectable delivery systems. The results obtained confirm the localization of microspheres to the injected target area and highlight the novelty of tracking delivery vehicles for other applications.
authors.affiliation: Department of Biomedical Engineering, University of Wisconsin, 3152 Engineering Centers Building, 1550 Engineering Drive, Madison, WI 53705, USA.
authors.forename: Travelle
authors.initials: T
authors.lastname: Franklin-Ford
authors.forename: Nehal
authors.initials: N
authors.lastname: Shah
authors.forename: Ellen
authors.initials: E
authors.lastname: Leiferman
authors.forename: Connie S
authors.initials: CS
authors.lastname: Chamberlain
authors.forename: Amish
authors.initials: A
authors.lastname: Raval
authors.forename: Ray
authors.initials: R
authors.lastname: Vanderby
authors.forename: William L
authors.initials: WL
authors.lastname: Murphy
mesh_terms: D000818:Animals; D003287:Contrast Media / Q000737:chemistry* / Q000627:therapeutic use; D016503:Drug Delivery Systems / Q000379:methods*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008280:Magnetics; D058185:Magnetite Nanoparticles / Q000737:chemistry* / Q000627:therapeutic use; D008863:Microspheres; D009132:Muscles / Q000648:ultrastructure; D019047:Phantoms, Imaging; D011098:Polyglactin 910; D051381:Rats; D017208:Rats, Wistar
chemical_list: D003287:Contrast Media; D058185:Magnetite Nanoparticles; D011098:Polyglactin 910