title: HIV-1 RNA shedding in the female genital tract is associated with reduced quantity of Lactobacilli in clinically asymptomatic HIV-positive women.
abstract: We quantified vaginal lactobacilli and determined their relationship with genital HIV-1 shedding and found a significant negative association between reduced quantity of lactobacilli and cervical HIV-1 viral load (r(2) = - 0.8900, P < 0.01), which may have implications of increased chances of sexual transmission of HIV-1 and genital infections.
authors.affiliation: National AIDS Research Institute, 73 G block, MIDC, Bhosari, Pune 411026, Maharashtra, India. amane@nariindia.org
authors.forename: Arati
authors.initials: A
authors.lastname: Mane
authors.forename: Smita
authors.initials: S
authors.lastname: Kulkarni
authors.forename: Manisha
authors.initials: M
authors.lastname: Ghate
authors.forename: Arun
authors.initials: A
authors.lastname: Risbud
authors.forename: Madhuri
authors.initials: M
authors.lastname: Thakar
mesh_terms: D000328:Adult; D058070:Asymptomatic Diseases; D058491:Bacterial Load; D003430:Cross-Sectional Studies; D005260:Female; D015658:HIV Infections / Q000821:virology*; D015497:HIV-1 / Q000235:genetics*; D006801:Humans; D007778:Lactobacillus / Q000302:isolation & purification*; D012367:RNA, Viral / Q000302:isolation & purification*; D014621:Vagina / Q000382:microbiology*; D017201:Virus Shedding
chemical_list: D012367:RNA, Viral