title: Adjunctive use of a facial moisturizer SPF 30 containing ceramide precursor improves tolerability of topical tretinoin 0.05%: a randomized, investigator-blinded, split-face study.
abstract: OBJECTIVE
  To assess the benefit of adjunctive use of a SPF 30 moisturizing lotion in reducing local side effects associated with atopical tretinoin cream.
  
  
  METHODS
  This was a randomized, investigator/evaluator-blinded, split-face comparison in subjects with healthy skin. Subjects applied tretinoin cream 0.05% once daily to the whole face and Cetaphil 174; Dermacontrol Moisturizer (CDM) once daily to one side of the face based on randomization. Tolerability, perference and skin hydration were evaluated at each week, and a cosmetic acceptability questionnaire regarding CDM was completed at the end of the study.
  
  
  RESULTS
  The majority (about 83% to 86%) of subjects experienced skin irritations on both sides of their face, though predominantly mild for the CDM + tretinoin treated side. Tolerability preferences favored the CDM+tretinoin sides. Adjunctive use of CDM with a topical tretinoin cream improves tolerance of the treatment.
authors.affiliation: TKL Research, Inc, Paramus, NJ 07652, USA. eschorr@tklresearch.com
authors.forename: Ethlynn S
authors.initials: ES
authors.lastname: Schorr
authors.forename: Farzi
authors.initials: F
authors.lastname: Sidou
authors.forename: Nabil
authors.initials: N
authors.lastname: Kerrouche
mesh_terms: D000279:Administration, Cutaneous; D000293:Adolescent; D000328:Adult; D000368:Aged; D002518:Ceramides / Q000008:administration & dosage*; D003879:Dermatologic Agents / Q000008:administration & dosage / Q000009:adverse effects*; D004338:Drug Combinations; D004643:Emollients / Q000008:administration & dosage*; D005260:Female; D006801:Humans; D007641:Keratolytic Agents / Q000008:administration & dosage / Q000009:adverse effects; D008297:Male; D008875:Middle Aged; D011409:Propylene Glycols / Q000008:administration & dosage; D016037:Single-Blind Method; D012967:Sodium Dodecyl Sulfate / Q000008:administration & dosage; D059405:Sun Protection Factor; D011795:Surveys and Questionnaires; D014212:Tretinoin / Q000008:administration & dosage / Q000009:adverse effects*; D055815:Young Adult
chemical_list: D002518:Ceramides; D003879:Dermatologic Agents; D004338:Drug Combinations; D004643:Emollients; D007641:Keratolytic Agents; D011409:Propylene Glycols; C011189:cetyl alcohol, propylene glycol, sodium lauryl sulfate non-lipid cleansing lotion; D012967:Sodium Dodecyl Sulfate; D014212:Tretinoin