title: Initiation and regulation of complement during hemolytic transfusion reactions.
abstract: Hemolytic transfusion reactions represent one of the most common causes of transfusion-related mortality. Although many factors influence hemolytic transfusion reactions, complement activation represents one of the most common features associated with fatality. In this paper we will focus on the role of complement in initiating and regulating hemolytic transfusion reactions and will discuss potential strategies aimed at mitigating or favorably modulating complement during incompatible red blood cell transfusions.
authors.affiliation: Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA.
authors.forename: Sean R
authors.initials: SR
authors.lastname: Stowell
authors.forename: Anne M
authors.initials: AM
authors.lastname: Winkler
authors.forename: Cheryl L
authors.initials: CL
authors.lastname: Maier
authors.forename: C Maridith
authors.initials: CM
authors.lastname: Arthur
authors.forename: Nicole H
authors.initials: NH
authors.lastname: Smith
authors.forename: Kathryn R
authors.initials: KR
authors.lastname: Girard-Pierce
authors.forename: Richard D
authors.initials: RD
authors.lastname: Cummings
authors.forename: James C
authors.initials: JC
authors.lastname: Zimring
authors.forename: Jeanne E
authors.initials: JE
authors.lastname: Hendrickson
mesh_terms: D000818:Animals; D001787:Blood Group Incompatibility / Q000276:immunology*; D003167:Complement Activation / Q000276:immunology*; D003165:Complement System Proteins / Q000276:immunology*; D017707:Erythrocyte Transfusion / Q000379:methods; D006461:Hemolysis / Q000276:immunology*; D006801:Humans
chemical_list: D003165:Complement System Proteins