title: Do baseline diastolic echocardiographic parameters predict outcome after resynchronization therapy? Results from the PROSPECT trial.
abstract: BACKGROUND
  Cardiac resynchronization therapy (CRT) can improve clinical and cardiac structural status in heart failure patients. The role of baseline diastolic echocardiographic parameters to characterize the likelihood of positive outcomes is not well known. We explored relationships between diastolic parameters and outcomes 6 months after CRT implant in the Predictors of Response to CRT (PROSPECT) Trial.
  
  
  OBJECTIVE
  We hypothesized that diastolic echocardiographic parameters were associated with clinical and structural outcomes in CRT patients.
  
  
  METHODS
  For 426 patients in PROSPECT, a prospective observational trial of CRT, baseline E/A ratio, left atrial (LA) area, isovolumic relaxation time, left ventricular inflow deceleration time, E' velocity, and E/E' ratio were evaluated and related to 6-month clinical composite score (CCS) and left ventricular end-systolic volume (LVESV) reduction using Spearman rank-order correlations. Parameters associated with outcomes were analyzed further by discrete categorization.
  
  
  RESULTS
  As continuous variables, only E/A ratio and LA area correlated with CCSs (P = 0.017, P = 0.045, respectively) and relative change in LVESV at 6 months (P < 0.0001, P = 0.001, respectively). As discrete variables, E/A ratio and LA area also correlated with CCSs and LVESV.
  
  
  CONCLUSIONS
  Diastolic echo parameters E/A ratio and LA area were associated with clinical and structural outcomes in CRT patients at 6 months.
authors.affiliation: University of Iowa Hospitals and Clinics, 200 Hawkins Drive, Iowa City, IA 52242, USA.
authors.forename: Renee M
authors.initials: RM
authors.lastname: Sullivan
authors.forename: Jaime
authors.initials: J
authors.lastname: Murillo
authors.forename: Bart
authors.initials: B
authors.lastname: Gerritse
authors.forename: Eugene
authors.initials: E
authors.lastname: Chung
authors.forename: Michael V
authors.initials: MV
authors.lastname: Orlov
authors.forename: Berthold
authors.initials: B
authors.lastname: Stegemann
authors.forename: Michelle
authors.initials: M
authors.lastname: Fedewa
authors.forename: Brett J
authors.initials: BJ
authors.lastname: Peterson
authors.forename: Jing Ping
authors.initials: JP
authors.lastname: Sun
authors.forename: Brian
authors.initials: B
authors.lastname: Olshansky
mesh_terms: D000368:Aged; D015897:Comorbidity; D004452:Echocardiography / Q000706:statistics & numerical data*; D005260:Female; D006333:Heart Failure / Q000000981:diagnostic imaging* / Q000517:prevention & control*; D006801:Humans; D008297:Male; D015995:Prevalence; D015203:Reproducibility of Results; D018570:Risk Assessment; D012307:Risk Factors; D012680:Sensitivity and Specificity; D013318:Stroke Volume; D014481:United States / Q000453:epidemiology; D018487:Ventricular Dysfunction, Left / Q000000981:diagnostic imaging* / Q000517:prevention & control*