title: A disulfide-linked conjugate of ferrocenyl chalcone and silicon(IV) phthalocyanine as an activatable photosensitiser.
abstract: A novel bis(ferrocenyl chalcone) silicon(IV) phthalocyanine has been prepared in which the disulfide linker can be cleaved by dithiothreitol. The separation of the ferrocenyl quencher and the phthalocyanine core greatly enhances the fluorescence emission, singlet oxygen production and in vitro photocytotoxicity.
authors.affiliation: Department of Chemistry, The Chinese University of Hong Kong, Shatin, N.T., Hong Kong.
authors.forename: Janet T F
authors.initials: JT
authors.lastname: Lau
authors.forename: Xiong-Jie
authors.initials: XJ
authors.lastname: Jiang
authors.forename: Dennis K P
authors.initials: DK
authors.lastname: Ng
authors.forename: Pui-Chi
authors.initials: PC
authors.lastname: Lo
mesh_terms: D002470:Cell Survival / Q000187:drug effects; D002599:Chalcone / Q000737:chemistry*; D004220:Disulfides / Q000737:chemistry*; D005296:Ferrous Compounds / Q000737:chemistry; D006801:Humans; D007211:Indoles / Q000737:chemistry*; D054833:Isoindoles; D061986:MCF-7 Cells; D000075163:Metallocenes; D018613:Microscopy, Confocal; D017319:Photosensitizing Agents / Q000737:chemistry* / Q000633:toxicity; D012825:Silicon / Q000737:chemistry; D026082:Singlet Oxygen / Q000737:chemistry / Q000378:metabolism
chemical_list: D004220:Disulfides; D005296:Ferrous Compounds; D007211:Indoles; D054833:Isoindoles; D000075163:Metallocenes; D017319:Photosensitizing Agents; D026082:Singlet Oxygen; D002599:Chalcone; C004998:ferrocene; C013647:phthalocyanine; D012825:Silicon