title: Anatomic and molecular development of corticostriatal projection neurons in mice.
abstract: Corticostriatal projection neurons (CStrPN) project from the neocortex to ipsilateral and contralateral striata to control and coordinate motor programs and movement. They are clinically important as the predominant cortical population that degenerates in Huntington's disease and corticobasal ganglionic degeneration, and their injury contributes to multiple forms of cerebral palsy. Together with their well-studied functions in motor control, these clinical connections make them a functionally, behaviorally, and clinically important population of neocortical neurons. Little is known about their development. "Intratelencephalic" CStrPN (CStrPNi), projecting to the contralateral striatum, with their axons fully within the telencephalon (intratelencephalic), are a major population of CStrPN. CStrPNi are of particular interest developmentally because they share hodological and axon guidance characteristics of both callosal projection neurons (CPN) and corticofugal projection neurons (CFuPN); CStrPNi send axons contralaterally before descending into the contralateral striatum. The relationship of CStrPNi development to that of broader CPN and CFuPN populations remains unclear; evidence suggests that CStrPNi might be evolutionary "hybrids" between CFuPN and deep layer CPN-in a sense "chimeric" with both callosal and corticofugal features. Here, we investigated the development of CStrPNi in mice-their birth, maturation, projections, and expression of molecular developmental controls over projection neuron subtype identity.
authors.affiliation: Department of Stem Cell and Regenerative Biology and Harvard Stem Cell Institute, Harvard University, Cambridge, MA, USA.
authors.forename: U Shivraj
authors.initials: US
authors.lastname: Sohur
authors.forename: Hari K
authors.initials: HK
authors.lastname: Padmanabhan
authors.forename: Ivan S
authors.initials: IS
authors.lastname: Kotchetkov
authors.forename: Joao R L
authors.initials: JR
authors.lastname: Menezes
authors.forename: Jeffrey D
authors.initials: JD
authors.lastname: Macklis
mesh_terms: D048868:Adaptor Proteins, Signal Transducing / Q000378:metabolism; D000818:Animals; D001369:Axons / Q000378:metabolism; D002540:Cerebral Cortex / Q000033:anatomy & histology* / Q000254:growth & development* / Q000378:metabolism; D003342:Corpus Striatum / Q000033:anatomy & histology* / Q000254:growth & development* / Q000378:metabolism; D004268:DNA-Binding Proteins / Q000378:metabolism; D007150:Immunohistochemistry; D007211:Indoles; D060588:LIM Domain Proteins / Q000378:metabolism; D036961:Matrix Attachment Region Binding Proteins / Q000378:metabolism; D051379:Mice; D009419:Nerve Tissue Proteins / Q000378:metabolism; D009434:Neural Pathways / Q000033:anatomy & histology / Q000254:growth & development / Q000378:metabolism; D056325:Neuronal Tract-Tracers; D009474:Neurons / Q000166:cytology* / Q000378:metabolism; D012097:Repressor Proteins / Q000378:metabolism; D055755:SOXD Transcription Factors / Q000378:metabolism; D014157:Transcription Factors / Q000378:metabolism; D025521:Tumor Suppressor Proteins / Q000378:metabolism
chemical_list: D048868:Adaptor Proteins, Signal Transducing; C511143:Bcl11b protein, mouse; D004268:DNA-Binding Proteins; D007211:Indoles; D060588:LIM Domain Proteins; C491976:Lmo4 protein, mouse; D036961:Matrix Attachment Region Binding Proteins; D009419:Nerve Tissue Proteins; D056325:Neuronal Tract-Tracers; D012097:Repressor Proteins; C501473:SATB2 protein, mouse; D055755:SOXD Transcription Factors; C089186:Sox5 protein, mouse; D014157:Transcription Factors; D025521:Tumor Suppressor Proteins; C412364:Zfp312 protein, mouse; C007293:DAPI
keywords: callosal projection neurons; corticofugal projection neurons; corticostriatal projection neurons; neocortex; striatum