title: Twin pregnancy and congenital cytomegalovirus: case report and review.
abstract: Primary cytomegalovirus (CMV) infection during pregnancy is the leading infectious cause of congenital neurological disabilities. Diagnosis of maternal primary CMV infection and fetal compromise can be difficult, as well as the fact that most infected child are asymptomatic at birth, which makes binomial CMV and pregnancy challenging. The treatment of pregnant women with CMV hyperimmunoglobulin (CMV-HIG) has shown promising results. However, as far as we know, no randomized trials of immunoglobulin therapy of CMV-infected fetuses are ongoing. We describe CMV-HIG administration for twin pregnancy as maternal and fetal infection early in gestation. The epidemiology, clinical manifestations, prevention strategies and treatment of CMV infections are reviewed.
authors.affiliation: Hospital Israelita Albert Einstein, Maternal and Fetal Medicine Department, São Paulo, Brazil. christiane.simioni@einstein.br
authors.forename: Christiane
authors.initials: C
authors.lastname: Simioni
authors.forename: Rita de Cassia
authors.initials: Rde C
authors.lastname: Sanchez Oliveira
authors.forename: Thomas
authors.initials: T
authors.lastname: Moscovi
authors.forename: Alice
authors.initials: A
authors.lastname: D' Agostini Deutsch
authors.forename: Eduardo
authors.initials: E
authors.lastname: Cordioli
authors.forename: Erica
authors.initials: E
authors.lastname: Santos
mesh_terms: D000328:Adult; D003586:Cytomegalovirus Infections / Q000151:congenital* / Q000628:therapy; D005260:Female; D006801:Humans; D007116:Immunization, Passive; D007136:Immunoglobulins / Q000627:therapeutic use*; D016756:Immunoglobulins, Intravenous; D007231:Infant, Newborn; D007234:Infant, Premature; D007235:Infant, Premature, Diseases / Q000821:virology*; D008297:Male; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000628:therapy / Q000821:virology*; D059285:Pregnancy, Twin
chemical_list: D007136:Immunoglobulins; D016756:Immunoglobulins, Intravenous; C045781:cytomegalovirus-specific hyperimmune globulin