title: Severe cytomegalovirus infections in immunocompetent patients at admission as dengue mimic: successful treatment with intravenous ganciclovir.
abstract: Cytomegalovirus (CMV) infection is associated with adverse clinical outcomes in immunosuppressed persons. The incidence and association of CMV reactivation with adverse clinical outcomes in critically ill persons lacking evidence of immunosuppression at ICU admission has received great attention in the practice of critical care medicine. Critically ill patients in ICU who had associated risk factors such as mechanical ventilation, severe sepsis, or blood transfusion are more prone to CMV activation, which in turn led to increased mortality and morbidity in terms of increased ICU stay, longer duration of mechanical ventilation, and higher rates of nosocomial infections. However, severe CMV as initial presentation mimicking dengue infection is rare. We recently came across seven cases with positive CMV serology at ICU admission, which we discuss in the light of current literature.
authors.affiliation: Yashoda Hospital, Secunderabad, India.
authors.forename: Suhasini
authors.initials: S
authors.lastname: Tirumala
authors.forename: Bijayini
authors.initials: B
authors.lastname: Behera
authors.forename: Shilpa
authors.initials: S
authors.lastname: Lingala
authors.forename: B Vijay
authors.initials: BV
authors.lastname: Kumar
authors.forename: Pradeep Kumar
authors.initials: PK
authors.lastname: Mishra
authors.forename: J M
authors.initials: JM
authors.lastname: Gurunath
authors.lastname: HariCharan
authors.lastname: Kartik
authors.lastname: Naresh
mesh_terms: D061605:Administration, Intravenous; D003586:Cytomegalovirus Infections / Q000175:diagnosis* / Q000188:drug therapy* / Q000473:pathology; D003715:Dengue / Q000175:diagnosis*; D003937:Diagnosis, Differential; D005260:Female; D015774:Ganciclovir / Q000008:administration & dosage*; D006801:Humans; D008297:Male; D008875:Middle Aged; D012698:Serologic Tests; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D015774:Ganciclovir