title: In vivo tracking techniques for cellular regeneration, replacement, and redirection.
abstract: Cellular therapy can be defined as the transplantation of living cells for the treatment of medical conditions. Three main objectives of cellular therapy are regeneration of damaged tissue, replacement of function by secretion of biologically active molecules, and redirection of aberrant processes. Given the complex nature of these approaches, in vivo tracking of the transplanted cells is critical to evaluate their potential benefit and to optimize treatment strategies. Recent advances are reviewed that enable in vivo cell tracking as an important adjunct to implement cellular therapy in clinical practice.
authors.affiliation: Department of Tumor Immunology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands. E.Aarntzen@nucmed.umcn.nl
authors.forename: Erik H J G
authors.initials: EH
authors.lastname: Aarntzen
authors.forename: Mangala
authors.initials: M
authors.lastname: Srinivas
authors.forename: Piotr
authors.initials: P
authors.lastname: Walczak
authors.forename: Miroslaw
authors.initials: M
authors.lastname: Janowski
authors.forename: Arend
authors.initials: A
authors.lastname: Heerschap
authors.forename: I Jolanda M
authors.initials: IJ
authors.lastname: de Vries
authors.forename: Carl G
authors.initials: CG
authors.lastname: Figdor
authors.forename: Jeff W M
authors.initials: JW
authors.lastname: Bulte
authors.forename: Wim J G
authors.initials: WJ
authors.lastname: Oyen
mesh_terms: D017690:Cell Transplantation / Q000379:methods*; D064987:Cell- and Tissue-Based Therapy / Q000379:methods*; D006801:Humans; D057054:Molecular Imaging / Q000379:methods*; D012038:Regeneration