title: Fluostatins I-K from the South China Sea-derived micromonospora rosaria SCSIO N160.
abstract: The strain SCSIO N160 was isolated from a South China Sea sediment sample and was characterized as a Micromonospora rosaria species on the basis of its 16S rRNA gene sequence. Three new fluostatins, I-K (1-3), were isolated from the culture of M. rosaria SCSIO N160, together with six known compounds, fluostatins C-F (4-7), rabelomycin (8), and phenanthroviridone (9). The structure of fluostatin D (5) was confirmed by an X-ray crystallographic study. The absolute configuration of 1 and 3 was assigned by electronic circular dichroism calculations. Compounds 8 and 9 exhibited good antimicrobial activities against Staphylococcus aureus ATCC 29213 with MIC values of 1.0 and 0.25 μg/mL, respectively. Compound 9 also exhibited significant in vitro cytotoxic activities toward SF-268 (IC50 0.09 μM) and MCF-7 (IC50 0.17 μM).
authors.affiliation: CAS Key Laboratory of Marine Bio-resources Sustainable Utilization, RNAM Center for Marine Microbiology, Guangdong Key Laboratory of Marine Materia Medica, South China Sea Institute of Oceanology, Chinese Academy of Sciences , 164 West Xingang Road, Guangzhou 510301, People's Republic of China.
authors.forename: Wenjun
authors.initials: W
authors.lastname: Zhang
authors.forename: Zhong
authors.initials: Z
authors.lastname: Liu
authors.forename: Sumei
authors.initials: S
authors.lastname: Li
authors.forename: Yongzhi
authors.initials: Y
authors.lastname: Lu
authors.forename: Yuchan
authors.initials: Y
authors.lastname: Chen
authors.forename: Haibo
authors.initials: H
authors.lastname: Zhang
authors.forename: Guangtao
authors.initials: G
authors.lastname: Zhang
authors.forename: Yiguang
authors.initials: Y
authors.lastname: Zhu
authors.forename: Gaiyun
authors.initials: G
authors.lastname: Zhang
authors.forename: Weimin
authors.initials: W
authors.lastname: Zhang
authors.forename: Jinsong
authors.initials: J
authors.lastname: Liu
authors.forename: Changsheng
authors.initials: C
authors.lastname: Zhang
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D001412:Bacillus subtilis / Q000187:drug effects; D002176:Candida albicans / Q000187:drug effects; D018360:Crystallography, X-Ray; D004354:Drug Screening Assays, Antitumor; D004926:Escherichia coli / Q000187:drug effects; D005260:Female; D005449:Fluorenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D019015:Geologic Sediments; D006801:Humans; D008826:Microbial Sensitivity Tests; D008847:Micromonospora / Q000737:chemistry*; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D009792:Oceans and Seas; D012336:RNA, Ribosomal, 16S / Q000235:genetics; D013211:Staphylococcus aureus / Q000187:drug effects; D013302:Streptomyces / Q000737:chemistry
chemical_list: D000900:Anti-Bacterial Agents; D000970:Antineoplastic Agents; D005449:Fluorenes; D012336:RNA, Ribosomal, 16S; C512874:fluostatin D; C587742:fluostatin I; C587743:fluostatin J; C587744:fluostatin K