title: Expression of the cysteinyl leukotriene 1 receptor and glucocorticoid receptor-β in nasal polyps.
abstract: The objective of this study was to analyze the expression of cysteinyl leukotriene 1 (CysLT1) receptor and glucocorticoid receptors (GRs) in nasal polyps, and to evaluate the relationship between the expression of CysLT1 receptors and that of GRs. Nasal polyps were taken from 32 patients of chronic rhinosinusitis with nasal polyposis. Samples of middle turbinate from seven healthy subjects were used as controls. Specimens were immunohistochemically stained for CysLT1 receptor, GR-α and GR-β receptor, and were quantified in the unit area of the tissues. Numbers of CysLT1 receptor-positive cells were much increased in nasal polyps than in middle turbinate (281 ± 67 vs. 157 ± 85 cells/mm(2), P = .01). There was no significant difference in the numbers of GR-α positive cells between nasal polyps and normal turbinate mucosa. GR-β positive cells were increased in nasal polyps as compared to normal turbinate mucosa (36 ± 8 vs. 19 ± 7 cells/mm(2), P = .03). A significant relationship was found between the expression of CysLT1 receptor and GR-β in nasal polyps (R = .525, P = .04), whereas there was no significant relationship between the expression of CysLT1 receptor and GR-α in nasal polyps. Our study shows that CysLT1 receptor expression predominates on GR-β over-expressed polyps. This may suggest the additional effect of CysLT1 receptor antagonist for the treatment of nasal polyposis resistant to steroid alone.
authors.affiliation: Department of Otorhinolaryngology, Seoul National University College of Medicine, Seoul National University Hospital, 101 Daehangno, Jongno-gu, Seoul 110-744, Korea. an0072@hanmail.net
authors.forename: Yong-Hwi
authors.initials: YH
authors.lastname: An
authors.forename: Sung-Lyong
authors.initials: SL
authors.lastname: Hong
authors.forename: Doo Hee
authors.initials: DH
authors.lastname: Han
authors.forename: Chul Hee
authors.initials: CH
authors.lastname: Lee
authors.forename: Yang-Gi
authors.initials: YG
authors.lastname: Min
authors.forename: Chae-Seo
authors.initials: CS
authors.lastname: Rhee
mesh_terms: D000328:Adult; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D002908:Chronic Disease; D005260:Female; D015870:Gene Expression / Q000235:genetics; D006801:Humans; D007124:Immunoenzyme Techniques; D008297:Male; D008661:Metabolism, Inborn Errors / Q000235:genetics; D008875:Middle Aged; D009297:Nasal Mucosa / Q000473:pathology; D009298:Nasal Polyps / Q000235:genetics* / Q000473:pathology; D011239:Prednisolone / Q000627:therapeutic use; D011292:Premedication; D011965:Receptors, Glucocorticoid / Q000032:analysis / Q000172:deficiency / Q000235:genetics*; D018077:Receptors, Leukotriene / Q000032:analysis / Q000235:genetics*
chemical_list: D000893:Anti-Inflammatory Agents; D011965:Receptors, Glucocorticoid; D018077:Receptors, Leukotriene; C121943:glucocorticoid receptor beta; D011239:Prednisolone; C083169:leukotriene D4 receptor