title: Brighter eyes: combined upper cheek and tear trough augmentation: a systematic approach utilizing two complementary hyaluronic acid fillers.
abstract: Non-surgical rejuvenation of the periorbital-cheek complex can be effectively and safely accomplished using a combination of two hyaluronic acid (HA) fillers with distinct viscosities. We present a series of 21 patients with mild to moderate tear trough deformities who were treated with concomitant injection of two dermal fillers (Restylane® and Perlane®). Procedural technique entailed micro-depot injections of the finer viscosity HA into the sub-muscular plane along the orbital rim followed by manual massage. Secondly, injections of the thicker, more firm HA were placed in the sub-muscular and/or deep dermal spaces in the upper malar and lateral zygomatic areas and in the medial aspect of the temporal fossa. On average 0.5 mL Restylane and 0.5 mL Perlane were used per side. Statistically significant improvement in modified Wrinkle Severity Rating Scale scores was seen at 20 weeks. Overall improvement in modified Global Aesthetic Improvement Scale scores occurred in 20 out of 21 patients. Mean patient satisfaction scores increased by 2 grades relative to baseline. Patients' self-reported overall mean improvement was 2.23, indicating moderate (26% to 50%) to good (51% to 75%) improvement. Side effects were limited to transient bruising and swelling. No patients required dissolution of injectant with hyaluronidase. Overall, this combination filler procedure was found to produce both statistically significant and clinically apparent improvement and was associated with an extremely high degree of patient satisfaction.
authors.affiliation: Loyola University, Stritch School of Medicine, Division of Dermatology, LaGrange Park, IL, USA.
authors.forename: Rebecca
authors.initials: R
authors.lastname: Tung
authors.forename: Arlene M
authors.initials: AM
authors.lastname: Ruiz de Luzuriaga
authors.forename: Kelly
authors.initials: K
authors.lastname: Park
authors.forename: Mauricio
authors.initials: M
authors.lastname: Sato
authors.forename: Meghan
authors.initials: M
authors.lastname: Dubina
authors.forename: Murad
authors.initials: M
authors.lastname: Alam
mesh_terms: D000328:Adult; D003357:Cosmetic Techniques / Q000009:adverse effects; D005145:Face; D005260:Female; D006801:Humans; D006820:Hyaluronic Acid / Q000008:administration & dosage* / Q000009:adverse effects / Q000031:analogs & derivatives / Q000737:chemistry; D007267:Injections; D017060:Patient Satisfaction; D012060:Rejuvenation; D012720:Severity of Illness Index; D015595:Skin Aging / Q000187:drug effects*; D016896:Treatment Outcome; D014783:Viscosity
chemical_list: C502935:Perlane; D006820:Hyaluronic Acid; C445361:Restylane