title: Serum liver fatty acid binding protein levels correlate positively with obesity and insulin resistance in Chinese young adults.
abstract: BACKGROUND
  Liver fatty acid-binding protein (FABP1) plays an inconclusive role in adiposity. We investigated the association of serum FABP1 levels with obesity and insulin resistance in Chinese young people under 30 years old.
  
  
  RESULTS
  Cross-sectional analysis including 200 obese and 172 normal-weight subjects matched for age and sex, anthropometric measurements were performed and serum FABP1 and biochemical characteristics were measured. Insulin resistance was determined by homeostasis model assessment of insulin resistance (HOMA-IR) and by the insulin sensitivity index (S(i)) derived from Bergman's minimal model. FABP1 levels in obese subjects were significantly higher than those in normal-weight subjects (p<0.001) and the significance remained after adjustment for age, gender, alanine and aspartate aminotransferases (p<0.001). Serum FABP1 levels were significantly correlated with many metabolic-related parameters, with BMI and triglycerides as the independent determinants. FABP1 levels remained an independent risk factor of insulin resistance assessed by binary S(i) (OR = 1.868 per SD unit, 95% CI [1.035-3.373], p = 0.038) after adjustment for age, sex, BMI, waist circumference, systolic blood pressure, serum triacylglycerol, total cholesterol, HDL- and LDL-cholesterol,. FABP1 levels were also elevated with an increasing number of components of the metabolic syndrome (p for trend <0.001). Multiple regression modeling for the MetS and its components demonstrated that hypertriglyceridemia and low HDL-cholesterol were significantly correlated to serum FABP1 levels.
  
  
  CONCLUSIONS
  Serum FABP1 correlates positively with obesity and insulin resistance in Chinese young adults. Our data supports the fact that FABP1 might be an important mediator participating in fatty acid metabolism and energy balance.
authors.affiliation: Shanghai Clinical Center for Endocrine and Metabolic Diseases, Shanghai Institute of Endocrinology and Metabolism, Endocrine and Metabolic E-Institutes of Shanghai Universities-EISU, Shanghai, China.
authors.forename: Juan
authors.initials: J
authors.lastname: Shi
authors.forename: Yifei
authors.initials: Y
authors.lastname: Zhang
authors.forename: Weiqiong
authors.initials: W
authors.lastname: Gu
authors.forename: Bin
authors.initials: B
authors.lastname: Cui
authors.forename: Min
authors.initials: M
authors.lastname: Xu
authors.forename: Qun
authors.initials: Q
authors.lastname: Yan
authors.forename: Weiqing
authors.initials: W
authors.lastname: Wang
authors.forename: Guang
authors.initials: G
authors.lastname: Ning
authors.forename: Jie
authors.initials: J
authors.lastname: Hong
mesh_terms: D000328:Adult; D002681:China; D003430:Cross-Sectional Studies; D050556:Fatty Acid-Binding Proteins / Q000097:blood*; D005260:Female; D006801:Humans; D007333:Insulin Resistance; D008297:Male; D024821:Metabolic Syndrome; D009765:Obesity / Q000097:blood*; D012044:Regression Analysis; D055815:Young Adult
chemical_list: D050556:Fatty Acid-Binding Proteins