title: Valproic acid treatment is associated with altered leukocyte subset development.
abstract: Valproic acid (VPA) has been used for decades in the treatment of epilepsy and psychiatric disorders, and the long-term use of VPA is regularly accompanied by hematological toxicity, including neutropenia. More recently, it has been demonstrated that VPA can be used as a histone deacetylase inhibitor (HDACi) for the treatment of hematological malignancies. In order to determine the specific effects of VPA in both hematological malignancies and normal hematopoiesis, recent studies have demonstrated that VPA treatment affects the differentiation of normal myeloid progenitors in vitro. In this study, we demonstrate that in a large patient population treated for neurological or psychiatric disorders, VPA treatment affects neutrophil as well as lymphocyte subset counts.
authors.affiliation: Department of Cell Biology, University Medical Center Utrecht, Utrecht, The Netherlands. mbartel2@umcutrecht.nl
authors.forename: Marije
authors.initials: M
authors.lastname: Bartels
authors.forename: Wouter W
authors.initials: WW
authors.lastname: van Solinge
authors.forename: Hanneke J
authors.initials: HJ
authors.lastname: den Breeijen
authors.forename: Marc B
authors.initials: MB
authors.lastname: Bierings
authors.forename: Paul J
authors.initials: PJ
authors.lastname: Coffer
authors.forename: Toine C G
authors.initials: TC
authors.lastname: Egberts
mesh_terms: D004804:Eosinophils / Q000187:drug effects / Q000473:pathology; D006410:Hematopoiesis / Q000187:drug effects* / Q000502:physiology; D006801:Humans; D007958:Leukocyte Count / Q000379:methods; D007962:Leukocytes / Q000166:cytology / Q000187:drug effects* / Q000473:pathology*; D016131:Lymphocyte Subsets / Q000187:drug effects / Q000473:pathology; D001523:Mental Disorders / Q000097:blood / Q000188:drug therapy / Q000473:pathology; D009000:Monocytes / Q000187:drug effects / Q000473:pathology; D009504:Neutrophils / Q000187:drug effects / Q000473:pathology; D016896:Treatment Outcome; D014635:Valproic Acid / Q000009:adverse effects* / Q000097:blood
chemical_list: D014635:Valproic Acid