title: Salivary proteomics in biomedical research.
abstract: Proteins that are important indicators of physiological or pathological states, can provide information for the identification of early and differential markers for disease. Saliva, contains an abundance of proteins, offers an easy, inexpensive, safe, and non-invasive approach for disease detection, and possesses a high potential to revolutionize the diagnostics. Discovery of salivary biomarkers could be used to scrutinize health and disease surveillance. The impact of human saliva proteome analysis in the search for clinically relevant disease biomarkers will be realized through advances made using proteomic technologies. The advancements of emerging proteomic techniques have benefited biomarker research to the point where saliva is now recognized as an excellent diagnostic medium for the detection of disease. This review presents an overview of the value of saliva as a credible diagnostic tool and we aim to summarize the proteomic technologies currently used for global analysis of saliva proteins and to elaborate on the application of saliva proteomics to the discovery of disease biomarkers, and discuss some of the critical challenges and perspectives in this field.
authors.affiliation: National TCM Key Lab of Serum Pharmacochemistry, Key Pharmacometabolomics Platform of Chinese Medicines, and Heilongjiang University of Chinese Medicine, Heping Road 24, Harbin 150040, China. aihua-zhang@163.com
authors.forename: Aihua
authors.initials: A
authors.lastname: Zhang
authors.forename: Hui
authors.initials: H
authors.lastname: Sun
authors.forename: Ping
authors.initials: P
authors.lastname: Wang
authors.forename: Xijun
authors.initials: X
authors.lastname: Wang
mesh_terms: D015415:Biomarkers / Q000032:analysis; D035843:Biomedical Research / Q000639:trends*; D002294:Carcinoma, Squamous Cell / Q000175:diagnosis / Q000378:metabolism; D003924:Diabetes Mellitus, Type 2 / Q000175:diagnosis / Q000378:metabolism; D006801:Humans; D009062:Mouth Neoplasms / Q000175:diagnosis / Q000378:metabolism; D020543:Proteome; D040901:Proteomics / Q000191:economics / Q000379:methods* / Q000639:trends; D012463:Saliva / Q000737:chemistry*; D012471:Salivary Proteins and Peptides / Q000032:analysis*; D012859:Sjogren's Syndrome / Q000175:diagnosis / Q000378:metabolism
chemical_list: D015415:Biomarkers; D020543:Proteome; D012471:Salivary Proteins and Peptides