title: [Association of factors of vascular tone regulation with the development of hemorrhagic transformation in patients with ischemic stroke].
abstract: Concentrations of plasma vascular tone regulation markers that are indicators of endothelium dysfunction in the acute phase of ischemic stroke and their effect on the development of hemorrhagic transformation (HT) of the lesion focus have been studied. Concentrations of renin, endothelin 1-21, neuron-specific enolase, NT-proCNP, soluble adhesion molecules (sICAM) were measured in 67 patients on days 1, 3-4. Significantly higher concentrations of renin, endothelin 1-21, neuron-specific enolase were found in patients with HT in the first day compared to patients without HT. The level of NT-proCNP was lower in patients with HT; the increase in the severity of hemorrhagic component led to the elevation of neuron-specific enolase and sICAM concentrations. In conclusion, both markers of blood-brain barrier damage and regulating factors of vascular tone may play a predictive role in the development of HT in ischemic stroke.
authors.forename: N A
authors.initials: NA
authors.lastname: Shamalov
authors.forename: A G
authors.initials: AG
authors.lastname: Kochetov
authors.forename: I M
authors.initials: IM
authors.lastname: Shetova
authors.forename: G R
authors.initials: GR
authors.lastname: Ramazanov
authors.forename: A Iu
authors.initials: AIu
authors.lastname: Botsina
authors.forename: A L
authors.initials: AL
authors.lastname: Luk'ianov
authors.forename: K V
authors.initials: KV
authors.lastname: Anisimov
authors.forename: A A
authors.initials: AA
authors.lastname: Arkhipkin
authors.forename: O V
authors.initials: OV
authors.lastname: Karpova
authors.forename: Iu V
authors.initials: IuV
authors.lastname: Novozhenova
authors.forename: M A
authors.initials: MA
authors.lastname: Kustova
authors.forename: V I
authors.initials: VI
authors.lastname: Skvortsova
mesh_terms: D000368:Aged; D015415:Biomarkers / Q000097:blood; D001812:Blood-Brain Barrier / Q000503:physiopathology*; D015815:Cell Adhesion Molecules / Q000097:blood; D019332:Endothelin-1 / Q000097:blood; D004730:Endothelium, Vascular / Q000503:physiopathology*; D005260:Female; D006801:Humans; D020300:Intracranial Hemorrhages / Q000097:blood / Q000209:etiology* / Q000503:physiopathology*; D008297:Male; D020098:Natriuretic Peptide, C-Type / Q000097:blood; D010751:Phosphopyruvate Hydratase / Q000097:blood; D012083:Renin / Q000097:blood; D020521:Stroke / Q000097:blood / Q000150:complications* / Q000503:physiopathology*
chemical_list: D015415:Biomarkers; D015815:Cell Adhesion Molecules; D019332:Endothelin-1; C480579:amino-terminal pro-C-type natriuretic peptide, human; D020098:Natriuretic Peptide, C-Type; D012083:Renin; D010751:Phosphopyruvate Hydratase