title: Recurrence of paroxysmal atrial fibrillation after cryoisolation of the pulmonary veins. Is a "redo" procedure using the cryoballoon useful?
abstract: BACKGROUND
  Pulmonary vein (PV) isolation with the cryoballoon technique is an effective and safe method to treat patients with paroxysmal atrial fibrillation (AF). However, the optimal treatment strategy for patients with recurrences after this ablation is unclear.
  
  
  OBJECTIVE
  The aim of this single centre study was to evaluate the efficacy and safety of a "redo" procedure using the cryoballoon in this patient cohort. The secondary study objectives were to determine the rate of reconduction for individual PVs of the patients undergoing "redo" ablation and potential predictors of persistent PV isolation (PVI).
  
  
  METHODS
  Between April 2006 and September 2009, all patients with paroxysmal AF recurrences after cryoballoon ablation a "redo" ablation with the cryoballoon was offered. PV conduction was determined and cryoapplications were performed in all reconnected PVs. Every 3 months, 7-day Holter ECG, symptom-driven transtelephonic ECG recordings, and questionnaires were collected for 12 months.
  
  
  RESULTS
  Forty-seven patients underwent "redo" cryoballoon ablation. In all these patients, at least one PV with reconduction was found. Recurrent conduction was documented in 63 % of the left superior PV, 56 % of the left inferior PV, 43 % of the right superior PV, and 56 % of the right inferior PV. In 28 of the 47 patients (60 %), no AF recurrence was detectable during the 12-month follow-up (after 3 months blanking period). Rate of severe complications was low and not significantly different from that of the initial ablations.
  
  
  CONCLUSIONS
  "Redo" ablation using cryoballoon technology may be an effective and safe method to treat patients with recurrence of paroxysmal AF after cryoballoon PVI.
authors.affiliation: Department of Electrophysiology, Heart and Vascular Center Bad Neustadt/Saale, Salzburger Leite 1, 97616, Bad Neustadt a.d. Saale, Germany. anja.schade@kardiologie-bad-neustadt.de
authors.forename: Anja
authors.initials: A
authors.lastname: Schade
authors.forename: Anke
authors.initials: A
authors.lastname: Langbein
authors.forename: Susanne
authors.initials: S
authors.lastname: Spehl
authors.forename: Sebastian
authors.initials: S
authors.lastname: Barth
authors.forename: Thomas
authors.initials: T
authors.lastname: Deneke
authors.forename: Guido
authors.initials: G
authors.lastname: Groschup
authors.forename: Marcus L
authors.initials: ML
authors.lastname: Koller
authors.forename: Burghard
authors.initials: B
authors.lastname: Schumacher
mesh_terms: D001281:Atrial Fibrillation / Q000175:diagnosis / Q000517:prevention & control* / Q000601:surgery*; D003452:Cryosurgery / Q000295:instrumentation* / Q000379:methods*; D005260:Female; D006329:Heart Conduction System / Q000601:surgery*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011667:Pulmonary Veins / Q000601:surgery*; D012086:Reoperation; D055502:Secondary Prevention; D016896:Treatment Outcome