title: Biomarkers of radiographic progression in psoriatic arthritis: a report from the GRAPPA 2011 annual meeting.
abstract: Clinical markers of radiographic progression have been studied in patients with psoriatic arthritis (PsA), and results have clearly confirmed the progression of radiographic damage over a 2-year period. Biomarkers of radiographic progression damage (erosion and new bone formation) have also been identified as a critical research issue in these patients. At the 2011 annual meeting of the Group for Research and Assessment of Psoriasis and Psoriatic Arthritis (GRAPPA), members discussed development of a pivotal observational study (PsA Biodam study) to determine the validity of several soluble biomarkers in predicting structural damage in patients with PsA receiving standard therapies. Specific protocol issues discussed were the inclusion criteria, selection of candidate biomarkers, timing of sample collection, the primary radiographic outcome measure, radiographic scoring methods, possible substudies, and funding strategies.
authors.affiliation: Department of Rheumatology, St. Vincent's University Hospital, Dublin, Ireland. Oliver.fitzgerald@ucd.ie
authors.forename: Oliver
authors.initials: O
authors.lastname: Fitzgerald
authors.forename: Christopher T
authors.initials: CT
authors.lastname: Ritchlin
authors.forename: Philip J
authors.initials: PJ
authors.lastname: Mease
mesh_terms: D018501:Antirheumatic Agents / Q000627:therapeutic use; D015535:Arthritis, Psoriatic / Q000000981:diagnostic imaging* / Q000188:drug therapy / Q000503:physiopathology*; D015415:Biomarkers; D018450:Disease Progression; D006801:Humans; D007558:Italy; D010012:Osteogenesis / Q000502:physiology; D017063:Outcome Assessment, Health Care; D011859:Radiography
chemical_list: D018501:Antirheumatic Agents; D015415:Biomarkers