title: [Role of lung affection in development of catecholamine-induced myocardial injury and its correction  (experimental study)].
abstract: The present research was focused on studies of adrenaline-induced morphological and biochemical alterations in rat lungs and myocardium and prevention of these changes by improvement of alveolar gas exchange.   The results obtained allow concluding that adrenaline-induced myocardial injury is a result of primary affection of lungs and suppression of alveolar gas exchange leading to generalized hypoxia and affection of cardiomyocytes. This is evidenced by prevention of myocardial injury in rats when preliminarily exposed to the mechanical lung ventilation prior to adrenaline injection.
authors.forename: A B
authors.initials: AB
authors.lastname: Semerdzhian
mesh_terms: D000818:Animals; D004837:Epinephrine / Q000633:toxicity; D006335:Heart Injuries / Q000139:chemically induced / Q000503:physiopathology / Q000628:therapy*; D006801:Humans; D055370:Lung Injury / Q000139:chemically induced / Q000503:physiopathology / Q000628:therapy*; D019001:Nitric Oxide Synthase / Q000378:metabolism; D011659:Pulmonary Gas Exchange; D051381:Rats; D012121:Respiration, Artificial
chemical_list: D019001:Nitric Oxide Synthase; D004837:Epinephrine