title: Diagnostic performance of conventional diffusion weighted imaging and diffusion tensor imaging for the liver fibrosis and inflammation.
abstract: OBJECTIVE
  To evaluate the diagnostic accuracy of liver apparent diffusion coefficient (ADC) measured with conventional diffusion-weighted imaging (CDI) and diffusion tensor imaging (DTI) for the diagnosis of liver fibrosis and inflammation.
  
  
  METHODS
  Thirty-seven patients with histologic diagnosis of chronic viral hepatitis and 34 healthy volunteers were included in this prospective study. All patients and healthy volunteers were examined by 3T MRI. CDI and DTI were performed using a breath-hold single-shot echo-planar spin echo sequence with b factors of 0 and 1000 s/mm(2). ADCs were obtained with CDI and DTI. Histopathologically, fibrosis of the liver parenchyma was classified with the use of a 5-point scale (0-4) and inflammation was classified with use of a 4-point scale (0-3) in accordance with the METAVIR score. Quantitatively, signal intensity and the ADCs of the liver parenchyma were compared between patients stratified by fibrosis stage and inflammation grade.
  
  
  RESULTS
  With a b factor of 1000 s/mm(2), the signal intensity of the cirrhotic livers was significantly higher than those of the normal volunteers. In addition, ADCs reconstructed from CDI and DTI of the patients were significantly lower than those of the normal volunteers. Liver ADC values inversely correlated with fibrosis and inflammation but there was only statistically significant for inflammatory grading. CDI performed better than DTI for the diagnosis of fibrosis and inflammation.
  
  
  CONCLUSIONS
  ADC values measured with CDI and DTI may help in the detection of liver fibrosis. They may also give contributory to the inflammatory grading, particularly in distinguishing high from low grade.
authors.affiliation: Department of Radiology, School of Medicine, University of Kocaeli, Turkey. mesude.tosun@kocaeli.edu.tr
authors.forename: Mesude
authors.initials: M
authors.lastname: Tosun
authors.forename: Nagihan
authors.initials: N
authors.lastname: Inan
authors.forename: Hasan Tahsin
authors.initials: HT
authors.lastname: Sarisoy
authors.forename: Gur
authors.initials: G
authors.lastname: Akansel
authors.forename: Sevtap
authors.initials: S
authors.lastname: Gumustas
authors.forename: Yeşim
authors.initials: Y
authors.lastname: Gürbüz
authors.forename: Ali
authors.initials: A
authors.lastname: Demirci
mesh_terms: D000328:Adult; D000368:Aged; D038524:Diffusion Magnetic Resonance Imaging / Q000379:methods*; D006525:Hepatitis, Viral, Human / Q000150:complications* / Q000473:pathology*; D006801:Humans; D008103:Liver Cirrhosis / Q000150:complications* / Q000473:pathology*; D008297:Male; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D055815:Young Adult