title: Biomimetic Synthesis of Cbz-(S)-Dolaphenine.
abstract: A new route to Cbz-(S)-dolaphenine, a recurring element in bioactive peptidic natural products, has been implemented, which closely parallels the biogenetic pathway. Cyclodehydration of 11 to yield thiazoline 2 allows for a Ni(0)-promoted decarbonylative aromatization to provide the thiazole framework with retention of stereochemistry.
authors.affiliation: Department of Chemistry, Indiana University, 800 E. Kirkwood Ave., Bloomington, IN, 47405, USA.
authors.forename: Pablo
authors.initials: P
authors.lastname: García-Reynaga
authors.forename: Michael S
authors.initials: MS
authors.lastname: Vannieuwenhze