title: Role of F-18 FDG PET/CT in assessing bone marrow involvement in pediatric Hodgkin's lymphoma.
abstract: OBJECTIVE
  The aim of the current study was to assess the utility of F-18-fluoro-2-deoxy-D-glucose (F-18 FDG) positron emission tomography/computed tomography (PET/CT) in assessing bone marrow involvement (BMI) compared to bone marrow biopsy (BMB) in initial staging of Hodgkin's lymphoma (HL) in pediatric patients.
  
  
  METHODS
  Data of 38 pediatric patients (mean age 9.8 years, range 3-18 years) with HL were analyzed for the involvement of bone marrow. All patients underwent non-contrast F-18 FDG PET/CT study. BMB was done in 31 patients from the bilateral iliac crests. Scans were interpreted by two nuclear medicine physicians blinded to the details of BMB.
  
  
  RESULTS
  Of the 31 patients who underwent BMB, 5 patients had lymphomatous involvement on BMB. PET/CT was positive in four of these five patients. In 26 patients negative on BMB, PET was negative in 23 patients and positive in 3 patients for BMI. The sensitivity and negative predictive value of F-18 FDG PET/CT was 87.5 and 96%, respectively, for BMI.
  
  
  CONCLUSIONS
  F-18 FDG PET/CT can predict BMB results with high accuracy. F-18 FDG PET/CT may be used at initial staging of pediatric Hodgkin's lymphoma as it uncovers unsuspected BMI and BMB may be omitted in patients with PET-positive BMI.
authors.affiliation: Department of Nuclear Medicine and PET, Postgraduate Institute of Medical Education and Research, Chandigarh, 160012, India.
authors.forename: Kanhaiyalal
authors.initials: K
authors.lastname: Agrawal
authors.forename: Bhagwant Rai
authors.initials: BR
authors.lastname: Mittal
authors.forename: Deepak
authors.initials: D
authors.lastname: Bansal
authors.forename: Neelam
authors.initials: N
authors.lastname: Varma
authors.forename: Radhika
authors.initials: R
authors.lastname: Srinivasan
authors.forename: Amita
authors.initials: A
authors.lastname: Trehan
authors.forename: Kuruva
authors.initials: K
authors.lastname: Manohar
authors.forename: Raghava
authors.initials: R
authors.lastname: Kashyap
authors.forename: Anish
authors.initials: A
authors.lastname: Bhattacharya
authors.forename: Ram K
authors.initials: RK
authors.lastname: Marwaha
mesh_terms: D000293:Adolescent; D001853:Bone Marrow / Q000000981:diagnostic imaging* / Q000473:pathology; D002648:Child; D002675:Child, Preschool; D005260:Female; D019788:Fluorodeoxyglucose F18; D006689:Hodgkin Disease / Q000000981:diagnostic imaging* / Q000473:pathology; D006801:Humans; D008297:Male; D064847:Multimodal Imaging; D009367:Neoplasm Staging; D049268:Positron-Emission Tomography; D012189:Retrospective Studies; D014057:Tomography, X-Ray Computed
chemical_list: D019788:Fluorodeoxyglucose F18