title: The kidney and planar cell polarity.
abstract: Planar cell polarity (PCP) or tissue polarity describes a coordinated polarity at the plane of the tissue where most or all cells within a tissue are polarized in one direction. It is perpendicular to the apical-basal polarity of the cell. PCP is manifested readily in the Drosophila wing and cuticle bristles, Drosophila eye ommatidia, and mammalian hair and inner ear hair bundles, and less evidently, in cellular processes such as in the coordinated, directional cell movements, and oriented cell divisions that are important for tissue morphogenesis. Several distinct molecular and cellular processes have been implicated in the regulation of PCP. Here, we review potential roles for PCP during mouse kidney development and maintenance, including ureteric bud branching morphogenesis, renal medulla elongation, tubule diameter establishment/maintenance, glomerulogenesis, and response to injury. The potential mechanisms underlying these processes, including oriented cell division and coordinated cell migration/cell intercalation, are discussed. In addition, we discuss some unaddressed research topics related to PCP in the kidney that we hope will spur further discussion and investigation.
authors.affiliation: Department of Internal Medicine (Nephrology) and Molecular Biology, UT Southwestern Medical Center, Dallas, Texas, USA. Thomas.Carroll@UTSouthwestern.edu
authors.forename: Thomas J
authors.initials: TJ
authors.lastname: Carroll
authors.forename: Jing
authors.initials: J
authors.lastname: Yu
mesh_terms: D000818:Animals; D015820:Cadherins / Q000235:genetics / Q000378:metabolism; D002455:Cell Division; D002465:Cell Movement; D016764:Cell Polarity; D002923:Cilia / Q000235:genetics / Q000378:metabolism*; D007365:Intercellular Junctions / Q000378:metabolism; D007668:Kidney / Q000166:cytology* / Q000254:growth & development / Q000293:injuries / Q000378:metabolism; D051379:Mice; D009024:Morphogenesis; D007690:Polycystic Kidney Diseases / Q000378:metabolism / Q000473:pathology; D025941:Protein Interaction Mapping; D051153:Wnt Proteins / Q000235:genetics / Q000378:metabolism; D060449:Wnt Signaling Pathway
chemical_list: D015820:Cadherins; C506554:Dchs1 protein, mouse; C506555:Fat4 protein, mouse; D051153:Wnt Proteins; C515303:Wnt9b protein, mouse