title: Risk of developing tuberculosis after brief exposure in Norwegian children: results of a contact investigation.
abstract: OBJECTIVE
  Prolonged exposure to adults with pulmonary tuberculosis is a risk factor for infecting children. We have studied to what extent a brief exposure may increase the risk of being infected in children.
  
  
  METHODS
  Observational study of a tuberculosis contact investigation.
  
  
  METHODS
  7 day-care centres and 4 after-school-care centres in Norway.
  
  
  METHODS
  606 1-year-old to 9-year-old children who were exposed briefly to a male Norwegian with smear-positive pulmonary tuberculosis.
  
  
  METHODS
  Number of children with latent and active tuberculosis detected by routine clinical examination, chest x-ray and use of a Mantoux tuberculin skin test (TST) and an interferon-γ release assay (IGRA).
  
  
  RESULTS
  The children were exposed to a mean of 6.9 h (range 3-18 h). 2-3 months after the exposure, 11 children (1.8%) had a TST ≥6 mm, 6 (1.0%) had TST 4-5 mm, and 587 (97.2%) had a negative TST result. Two children (0.3%) with negative chest x-rays who were exposed 4.75 and 12 h, respectively, had a positive IGRA test result, and were diagnosed with latent tuberculosis. None developed active tuberculosis.
  
  
  CONCLUSIONS
  Children from a high-income country attending day-care and after-school-care centres had low risk of being infected after brief exposure less than 18 h to an adult day-care helper with smear-positive pulmonary tuberculosis.
authors.affiliation: Department of Laboratory Medicine, Childrens and Womens Health,  Norwegian University of Science and Technology, Trondheim,  Norway.
authors.forename: Henrik
authors.initials: H
authors.lastname: Døllner
authors.forename: Christina Terez
authors.initials: CT
authors.lastname: Ramm
authors.forename: Ingunn
authors.initials: I
authors.lastname: Harstad
authors.forename: Jan Egil
authors.initials: JE
authors.lastname: Afset
authors.forename: Eli
authors.initials: E
authors.lastname: Sagvik