title: Alzheimer's disease with vascular component: a distinct clinical entity?
abstract: BACKGROUND
  Longitudinal reports on the clinical features of patients with Alzheimer's disease (AD) and concomitant cerebrovascular disease are scarce.
  
  
  METHODS
  We elaborated a working definition of AD with vascular component (ADVC), and this definition was retrospectively investigated in a cohort of patients with cognitive deterioration who were prescribed a cholinesterase inhibitor during usual practice.
  
  
  RESULTS
  A total of 137 patients with probable AD and 66 patients with ADVC were studied during a mean follow-up period of 2.8 years. Univariate analyses demonstrated worse functional evolution and anticipation of psychotic symptoms and agitation in the ADVC group.
  
  
  CONCLUSIONS
  The present results are consistent with an additive model of predominantly frontal-subcortical vascular damage in AD.
authors.affiliation: Hermanos Sangro Specialties Clinic, Service of Neurology, Gregorio Marañón University Hospital, Spain ; Alzheimer Disease Research Unit, CIEN Foundation, Carlos III Institute of Health, Alzheimer Center Reina Sofía Foundation, Spain.
authors.forename: Javier
authors.initials: J
authors.lastname: Olazarán
authors.forename: Eloísa
authors.initials: E
authors.lastname: Navarro
authors.forename: José Manuel
authors.initials: JM
authors.lastname: Rojo
keywords: Alzheimer's disease; Cerebrovascular disease; Clinical manifestations; White matter disease