title: Protective effect of Mollugo nudicaulis Lam. on acute liver injury induced by perchloroethylene in experimental rats.
abstract: OBJECTIVE
  To evaluate the protective effect of ethanol extract of Mollugo nudicaulis (M. nudicaulis) against perchloroethylene-induced hepatotoxicity.
  
  
  METHODS
  The hepatoprotective activity of the ethanol extract of M. nudicaulis (200 mg/kg body wt) was studied in percholoroethylene (1 000 mg/kg body wt) induced hepatotoxicity in Wistar albino rats. The serum levels of AST, ALT, ALP, bilirubin and the liver content of SOD, CAT, GPx, GST, GSH, vitamin C were assessed to evaluate the hepatoprotective and antioxidant activities of the extract. The activity of the extract was compared with silymarin, a standard reference drug. In addition, serum urea, uric acid and creatinine levels were measured to evaluate the kidney function. The histopathological examination of the liver tissues was observed to support the biochemical parameters.
  
  
  RESULTS
  The results revealed that the extract significantly (P<0.05) restored the serum levels of AST, ALT, ALP, bilirubin and significantly (P<0.05) increased the antioxidant enzymes SOD, CAT, GPx, GST, GSH, vitamin C in perchloroethylene-induced rats to its normalcy. The biochemical observations were supported by the histopathological studies of the liver tissues.
  
  
  CONCLUSIONS
  The results led to the conclusion that M. nudicaulis possess hepatoprotective and antioxidant activities against perchloroethylene-induced hepatotoxicity in rats.
authors.affiliation: Department of Bioinformatics, Karpagam University, Coimbatore, India.
authors.forename: Sundaraj
authors.initials: S
authors.lastname: Rajamanikandan
authors.forename: Thangaraj
authors.initials: T
authors.lastname: Sindhu
authors.forename: Dhanapal
authors.initials: D
authors.lastname: Durgapriya
authors.forename: Dominic
authors.initials: D
authors.lastname: Sophia
authors.forename: Paramasivam
authors.initials: P
authors.lastname: Ragavendran
authors.forename: Velliyur Kanniappan
authors.initials: VK
authors.lastname: Gopalakrishnan
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000008:administration & dosage* / Q000302:isolation & purification; D056486:Chemical and Drug Induced Liver Injury / Q000188:drug therapy* / Q000473:pathology; D003404:Creatinine / Q000097:blood; D004798:Enzymes / Q000097:blood; D005260:Female; D006651:Histocytochemistry; D008099:Liver / Q000201:enzymology; D035704:Molluginaceae / Q000737:chemistry*; D010936:Plant Extracts / Q000008:administration & dosage* / Q000302:isolation & purification; D051381:Rats; D017208:Rats, Wistar; D013750:Tetrachloroethylene / Q000633:toxicity*; D016896:Treatment Outcome; D014508:Urea / Q000097:blood; D014527:Uric Acid / Q000097:blood
chemical_list: D000975:Antioxidants; D004798:Enzymes; D010936:Plant Extracts; D014527:Uric Acid; D014508:Urea; D003404:Creatinine; D013750:Tetrachloroethylene