title: Diastereoselective and enantioselective desymmetrization of α-substituted cyclohexadienones via intramolecular Stetter reaction.
abstract: Highly diastereoselective and enantioselective desymmetrization of α-substituted cyclohexadienones via NHC-catalyzed intramolecular Stetter reaction was realized. Amino-indanol derived triazolium salt bearing a C(6)F(5) group was found to be the optimal catalyst precursor in the intramolecular Stetter reaction furnishing tricyclic products bearing multi-stereocenters in up to 96% yield and >99% ee.
authors.affiliation: State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Lu, Shanghai 200032, PR China.
authors.forename: Min-Qiang
authors.initials: MQ
authors.lastname: Jia
authors.forename: Chuan
authors.initials: C
authors.lastname: Liu
authors.forename: Shu-Li
authors.initials: SL
authors.lastname: You