title: Multiple toxicity studies of trehalose in mice by intragastric administration.
abstract: In the present study, aberration, body weight, food consumption, haematology, organ coefficients, and both gross and microscopic appearance of some histiocytes were compared between the test and control groups. A sperm abnormality test, bone marrow cell micronucleus test, and a haematology study were conducted at levels of 1.25 g/kg, 2.5 g/kg, and 5 g/kg of trehalose. In both the sperm abnormality test and bone marrow cell micronucleus test, statistically significant differences were observed between the positive control and treatment groups (P<0.05), while no statistical difference was observed among the negative control, high dose, moderate dose and low dose groups (P>0.05). In the haematology study, there was no significant difference found from the controls at P>0.05. The results obtained in the present study could support the conclusion that consumption of trehalose has no adverse effects for humans.
authors.affiliation: Laboratory of Nutrition and Functional Food, Jilin University, Changchun 130062, PR China.
authors.forename: Mingyuan
authors.initials: M
authors.lastname: Liu
authors.forename: Meishuo
authors.initials: M
authors.lastname: Zhang
authors.forename: Haiqing
authors.initials: H
authors.lastname: Ye
authors.forename: Songyi
authors.initials: S
authors.lastname: Lin
authors.forename: Yi
authors.initials: Y
authors.lastname: Yang
authors.forename: Liying
authors.initials: L
authors.lastname: Wang
authors.forename: Gregory
authors.initials: G
authors.lastname: Jones
authors.forename: Hung
authors.initials: H
authors.lastname: Trang
mesh_terms: D000818:Animals; D001835:Body Weight / Q000187:drug effects; D002460:Cell Line; D006801:Humans; D008297:Male; D051379:Mice; D009929:Organ Size / Q000187:drug effects; D012098:Reproduction / Q000187:drug effects; D013094:Spermatozoa / Q000187:drug effects; D014199:Trehalose / Q000008:administration & dosage / Q000633:toxicity*
chemical_list: D014199:Trehalose