title: Active transposition in genomes.
abstract: Transposons are DNA sequences capable of moving in genomes. Early evidence showed their accumulation in many species and suggested their continued activity in at least isolated organisms. In the past decade, with the development of various genomic technologies, it has become abundantly clear that ongoing activity is the rule rather than the exception. Active transposons of various classes are observed throughout plants and animals, including humans. They continue to create new insertions, have an enormous variety of structural and functional impact on genes and genomes, and play important roles in genome evolution. Transposon activities have been identified and measured by employing various strategies. Here, we summarize evidence of current transposon activity in various plant and animal genomes.
authors.affiliation: Institute of Genetic Medicine and High Throughput Biology Center, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA. chuang36@jhmi.edu
authors.forename: Cheng Ran Lisa
authors.initials: CR
authors.lastname: Huang
authors.forename: Kathleen H
authors.initials: KH
authors.lastname: Burns
authors.forename: Jef D
authors.initials: JD
authors.lastname: Boeke
mesh_terms: D000818:Animals; D017360:Arabidopsis / Q000235:genetics; D004251:DNA Transposable Elements; D019143:Evolution, Molecular; D005787:Gene Frequency; D014644:Genetic Variation; D015894:Genome, Human; D018745:Genome, Plant; D006801:Humans; D020084:Long Interspersed Nucleotide Elements; D016254:Mutagenesis, Insertional / Q000235:genetics*; D010641:Phenotype; D012641:Selection, Genetic; D020086:Short Interspersed Nucleotide Elements; D014170:Transformation, Genetic
chemical_list: D004251:DNA Transposable Elements