title: Development and evaluation of tamarind seed xyloglucan-based mucoadhesive buccal films of rizatriptan benzoate.
abstract: Mucoadhesive buccal films were developed using tamarind seed xyloglucan (TSX) as novel mucoadhesive polysaccharide polymer for systemic delivery of rizatriptan benzoate through buccal route. Formulations were prepared based on 3(2) factorial design with concentrations of TSX and carbopol 934P (CP) as independent variables. Three dependent variables considered were tensile strength, bioadhesion force and drug release. DSC analysis revealed no interaction between drug and polymers. Ex vivo diffusion studies were carried out using Franz diffusion cell, while bioadhesive properties were evaluated using texture analyzer with porcine buccal mucosa as model tissue. Results revealed that bilayer film containing 4% (w/v) TSX and 0.5% (w/v) CP in the drug layer and 1% (w/v) ethyl cellulose in backing layer demonstrated diffusion of 93.45% through the porcine buccal mucosa. Thus, this study suggests that tamarind seed polysaccharide can act as a potential mucoadhesive polymer for buccal delivery of a highly soluble drug like rizatriptan benzoate.
authors.affiliation: Department of Pharmaceutics, Sinhgad College of Pharmacy, Vadgaon (Bk.), Pune 411041, Maharashtra, India. prof_avachat@yahoo.com
authors.forename: Amelia M
authors.initials: AM
authors.lastname: Avachat
authors.forename: Kishore N
authors.initials: KN
authors.lastname: Gujar
authors.forename: Kishor V
authors.initials: KV
authors.lastname: Wagh
mesh_terms: D000269:Adhesives / Q000737:chemistry*; D000278:Administration, Buccal; D000818:Animals; D016503:Drug Delivery Systems; D005936:Glucans / Q000737:chemistry*; D008567:Membranes, Artificial; D009061:Mouth Mucosa / Q000378:metabolism; D017366:Serotonin Receptor Agonists / Q000008:administration & dosage*; D013552:Swine; D029861:Tamarindus / Q000737:chemistry; D013718:Tensile Strength; D014230:Triazoles / Q000008:administration & dosage*; D014363:Tryptamines / Q000008:administration & dosage*; D014990:Xylans / Q000737:chemistry*
chemical_list: D000269:Adhesives; D005936:Glucans; D008567:Membranes, Artificial; D017366:Serotonin Receptor Agonists; D014230:Triazoles; D014363:Tryptamines; D014990:Xylans; C029353:xyloglucan; C093622:rizatriptan