title: Parental and other factors associated with hydroxyurea use for pediatric sickle cell disease.
abstract: BACKGROUND
  Hydroxyurea (HU) is highly effective treatment for sickle cell disease (SCD). While pediatric use of HU is accepted clinical practice, barriers to use may impede its potential benefit.
  
  
  METHODS
  A survey of parents of children ages 5-17 years with SCD was performed across five institutions to assess factors associated with HU use.
  
  
  RESULTS
  Of the 173 parent responses, 65 (38%) had children currently taking HU. Among parents of children not taking HU, the most commonly cited reasons were that their hematology provider had not offered it, their child was not sufficiently symptomatic and concerns about potential side effects. Even parents of HU users reported widespread concern about effectiveness, long-term safety, and off-label use. In bivariate analyses, children's ages, parental demographics such as education level, or travel time to their hematology provider were not correlated with HU use. Bivariate analysis and multivariate logistic regression revealed three significant factors associated with current HU use: better parental knowledge about its major therapeutic effects (P < 0.001), sickle genotype (P = 0.005), and institution of clinical care (P = 0.04).
  
  
  CONCLUSIONS
  Pervasive concerns about HU safety exist, even among parents of current users. Varying knowledge among parents appears to be independent of their demographics, and is associated with HU use. Inter-institutional variability in parental knowledge and drug uptake highlights potentially potent site-specific influences on likelihood of HU use. Overall, these survey data underscore the need for strategies to bolster parental understanding about benefits of HU and address concerns about its safety.
authors.affiliation: Department of Pediatrics, Division of General Pediatrics, Children's Hospital at Montefiore, Albert Einstein College of Medicine of Yeshiva University, Bronx, New York 10467, USA. soyeku@montefiore.org
authors.forename: Suzette O
authors.initials: SO
authors.lastname: Oyeku
authors.forename: M Catherine
authors.initials: MC
authors.lastname: Driscoll
authors.forename: Hillel W
authors.initials: HW
authors.lastname: Cohen
authors.forename: Rebecca
authors.initials: R
authors.lastname: Trachtman
authors.forename: Farzana
authors.initials: F
authors.lastname: Pashankar
authors.forename: Craig
authors.initials: C
authors.lastname: Mullen
authors.forename: Patricia J
authors.initials: PJ
authors.lastname: Giardina
authors.forename: Nerissa
authors.initials: N
authors.lastname: Velazco
authors.forename: Andrew D
authors.initials: AD
authors.lastname: Racine
authors.forename: Nancy S
authors.initials: NS
authors.lastname: Green
mesh_terms: D000293:Adolescent; D000755:Anemia, Sickle Cell / Q000188:drug therapy*; D000986:Antisickling Agents / Q000627:therapeutic use*; D002648:Child; D002675:Child, Preschool; D003430:Cross-Sectional Studies; D005260:Female; D007722:Health Knowledge, Attitudes, Practice; D006801:Humans; D006918:Hydroxyurea / Q000627:therapeutic use*; D008297:Male; D010290:Parents
chemical_list: D000986:Antisickling Agents; D006918:Hydroxyurea