title: [Utility of capsule endoscopy with flexible spectral imaging color enhancement in the diagnosis of small bowel lesions].
abstract: BACKGROUND
  Capsule endoscopy (CE) is the technique of choice to detect small bowel lesions. Flexible spectral imaging color enhancement (FICE) software has recently been incorporated into the new RAPID 6.0 workstation, which allows three distinct patterns to be visualized in the mucosal structure according to different wavelengths. The aim of this study was to evaluate whether CE-FICE is more effective in detecting lesions than standard visualization.
  
  
  METHODS
  Fifty lesions were detected by CE in 41 consecutive patients in 2010. These patients were administered PillCamTM SB2 in our center and were classified into three groups: 1) vascular lesions and angiodysplasias (18 lesions), 2) erosions and ulcers (18 lesions) and 3) polyps and tumors (14 lesions). Subsequently, these lesions were independently analyzed with the available FICE patterns by three endoscopists, who assigned them a score according to the changes in the visualization of each FICE mode: +2, strong improvement; +1, slight improvement; 0, no relevant changes; -1, slight worsening; -2, clear worsening. When the sum of the scores of the three observers was 3 or more, visualization was considered to have improved; a score of 2 to -2 indicated no change; and a score of from -3 to -6 indicated poorer visualization.
  
  
  RESULTS
  The FICE 1 mode improved visualization of angiodysplastic and vascular lesions in 16/18 patients (88.9%) and that of erosions/ulcers in 14/18 patients (77.8%). The FICE 2 mode improved these lesions in 88.9% and 55.5%, respectively. The FICE 3 mode only improved visualization of these lesions in 5/18 (27.7%) and 1/18 patients (5.5%), respectively. Likewise, the distinct FICE modes improved visualization of polyps/tumors in 2/14 (14.2%), 3/13 (21.4%) and 4/14 (28.5%) for FICE 1, 2 and 3, respectively.
  
  
  CONCLUSIONS
  The application of CE-FICE modes 1 and 2 could improve the characterization of angiodysplastic/vascular lesions and erosions or ulcers in small bowel lesions. However, FICE 3 seems to provide no significant advantages. None of the CE-FICE modes seems to improve the characterization of polyps and tumors.
authors.affiliation: Servicio de Aparato Digestivo, Hospital General Universitario Gregorio Marañón, Madrid, España. oscarnogalesrincon@gmail.com
authors.forename: Oscar
authors.initials: O
authors.lastname: Nogales Rincón
authors.forename: Beatriz
authors.initials: B
authors.lastname: Merino Rodríguez
authors.forename: Cecilia
authors.initials: C
authors.lastname: González Asanza
authors.forename: Pedro Menchén
authors.initials: PM
authors.lastname: Fernández-Pacheco
mesh_terms: D053704:Capsule Endoscopy; D003116:Color; D006801:Humans; D007089:Image Enhancement; D007410:Intestinal Diseases / Q000473:pathology*; D007421:Intestine, Small / Q000473:pathology*