title: The co-occurrence of Hashimoto thyroiditis in primary Sjogren's syndrome defines a subset of patients with milder clinical phenotype.
abstract: To evaluate in a cohort of 100 consecutive patients affected by primary Sjogren's syndrome (pSS) the incidence of Hashimoto thyroiditis (HT) and to compare the clinical features and the laboratory parameters of patients affected by pSS with and without concomitant HT. In 100 consecutive patients affected by pSS, the occurrence of other autoimmune diseases was recorded and a full examination of thyroid function obtained. HT was associated with pSS in 27 cases. The comparison between pSS cases with and without HT showed that only patients with isolated pSS had low C4 level [p = 0.032, OR (IC 95 %) 230 (13.13-4,046)]. In addition, only patients affected by pSS without HT had evidence of cryoglobulins, cutaneous vasculitis with palpable purpura, peripheral neuropathy, and development of lymphoma, although all these manifestations were observed in a 4.1-8.2 % of the cases, without reaching statistical significance. The association of HT in patients suffering from pSS defines a subset of patients with milder disease and normal C4 levels.
authors.affiliation: Rheumatology Unit, Department of Medicine, University of Verona, Verona, Italy. paola.caramaschi@ospedaleuniverona.it
authors.forename: Paola
authors.initials: P
authors.lastname: Caramaschi
authors.forename: Domenico
authors.initials: D
authors.lastname: Biasi
authors.forename: Cristian
authors.initials: C
authors.lastname: Caimmi
authors.forename: Cinzia
authors.initials: C
authors.lastname: Scambi
authors.forename: Sara
authors.initials: S
authors.lastname: Pieropan
authors.forename: Giovanni
authors.initials: G
authors.lastname: Barausse
authors.forename: Silvano
authors.initials: S
authors.lastname: Adami
mesh_terms: D000328:Adult; D000368:Aged; D015415:Biomarkers / Q000097:blood; D016009:Chi-Square Distribution; D015897:Comorbidity; D018450:Disease Progression; D005260:Female; D050031:Hashimoto Disease / Q000097:blood / Q000175:diagnosis / Q000453:epidemiology* / Q000276:immunology; D006801:Humans; D015994:Incidence; D007558:Italy / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D010641:Phenotype; D011237:Predictive Value of Tests; D011379:Prognosis; D012720:Severity of Illness Index; D012859:Sjogren's Syndrome / Q000097:blood / Q000175:diagnosis / Q000453:epidemiology* / Q000276:immunology; D013960:Thyroid Function Tests
chemical_list: D015415:Biomarkers