title: Aberrant alternative splicing events in Parkinson's disease.
abstract: Alternative splicing (AS) using a sole gene to express multiple transcripts with diverse protein coding sequences and/or RNA regulatory elements raises genomic complexities. In the nervous system, several thousand AS events play important roles in ion transportation, receptor recognition, neurotransmission, memory, and learning. Not surprisingly, AS influences human physiology, development, and disease. Many research studies have focused on aberrant AS in nervous system diseases, including Parkinson's disease (PD), the second most common progressive neurodegenerative disorder of the central nervous system. PD affects the lives of several million people globally. It is caused by protein aggregation, such as in Lewy bodies, and the loss of dopaminecontaining neurons in the substantia nigra of the midbrain. To our knowledge, six genes, including PARK2, SNCAIP, LRRK2, SNCA, SRRM2, and MAPT, are involved in aberrant AS events in PD patients. In this review, we highlight the relevance of aberrant AS in PD and discuss the use of an aberrant AS profile as a potential diagnostic or prognostic marker for PD and as a possible means of applying therapy.
authors.affiliation: Center for Neuropsychiatry, China Medical University Hospital, Taichung, Taiwan, ROC.
authors.forename: Ru-Huei
authors.initials: RH
authors.lastname: Fu
authors.forename: Shih-Ping
authors.initials: SP
authors.lastname: Liu
authors.forename: Shyh-Jer
authors.initials: SJ
authors.lastname: Huang
authors.forename: Hung-Jen
authors.initials: HJ
authors.lastname: Chen
authors.forename: Pin-Ru
authors.initials: PR
authors.lastname: Chen
authors.forename: Ya-Hsien
authors.initials: YH
authors.lastname: Lin
authors.forename: Yu-Chen
authors.initials: YC
authors.lastname: Ho
authors.forename: Wen-Lin
authors.initials: WL
authors.lastname: Chang
authors.forename: Chang-Hai
authors.initials: CH
authors.lastname: Tsai
authors.forename: Woei-Cherng
authors.initials: WC
authors.lastname: Shyu
authors.forename: Shinn-Zong
authors.initials: SZ
authors.lastname: Lin
mesh_terms: D017398:Alternative Splicing / Q000235:genetics*; D000818:Animals; D006801:Humans; D010300:Parkinson Disease / Q000175:diagnosis / Q000235:genetics* / Q000628:therapy; D011379:Prognosis