title: An ocular form of myasthenia gravis with a high titer of anti-MuSK antibodies during a long-term follow-up.
abstract: We herein report a case of ocular myasthenia gravis (MG) that was highly positive for anti-muscle-specific tyrosine kinase (MuSK) antibodies. The examined patient exhibited bilateral ptosis and lateral gaze palsy without any generalized symptoms and was diagnosed with ocular MG with anti-MuSK antibodies. She responded to treatment with prednisolone and immunosuppressants and experienced only ocular symptoms for four years and eight months after onset. Ocular MG with anti-MuSK antibodies lasting for a long term has rarely been described. Our findings suggest that it may be reasonable to test for the presence of anti-MuSK antibodies in patients who present with external ophthalmoplegia.
authors.affiliation: Department of Neurology, Faculty of Medicine, University of Tsukuba, and Clinical Research Center, National Hospital Organization, Utano National Hospital, Japan.
authors.forename: Ai
authors.initials: A
authors.lastname: Hosaka
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Takuma
authors.forename: Kiyoe
authors.initials: K
authors.lastname: Ohta
authors.forename: Akira
authors.initials: A
authors.lastname: Tamaoka
mesh_terms: D000328:Adult; D001323:Autoantibodies / Q000097:blood*; D005128:Eye Diseases / Q000150:complications / Q000175:diagnosis / Q000201:enzymology / Q000276:immunology*; D005260:Female; D006801:Humans; D009157:Myasthenia Gravis / Q000150:complications / Q000175:diagnosis / Q000201:enzymology / Q000276:immunology*; D009886:Ophthalmoplegia / Q000209:etiology / Q000276:immunology; D020794:Receptor Protein-Tyrosine Kinases / Q000276:immunology*; D011950:Receptors, Cholinergic / Q000276:immunology*; D013997:Time Factors
chemical_list: D001323:Autoantibodies; D011950:Receptors, Cholinergic; C095714:MUSK protein, human; D020794:Receptor Protein-Tyrosine Kinases