title: Synthesis, structures and urease inhibition studies of Schiff base metal complexes derived from 3,5-dibromosalicylaldehyde.
abstract: Eleven mononuclear copper(II), nickel(II), zinc(II) and cobalt(II) complexes of Schiff base ligands derived from 3,5-dibromosalicylaldehyde/3,5-dichlorosalicylaldehyde were synthesized and determined by single crystal X-ray analysis. The crystal structures of complexes 1, 2, 4, 5, 6, 8 and 11 present the square-planar coordination geometry at the metal center and complexes 7, 9 and 10 show the distorted tetrahedral geometry. While one copper center in 3 has a square-planar geometry, the other copper is slightly distorted square-planar. The inhibitory activities of all the obtained complexes were tested in vitro against jack bean urease. It was found that Schiff base copper(II) complexes 1, 3, 5, 8 and 11 showed strong urease inhibitory activities (IC(50) = 1.51-3.52 μM) compared with acetohydroxamic acid (IC(50) = 62.52 μM), which was a positive reference. Their structure-activity relationships were further discussed.
authors.affiliation: Engineering Research Center for Clean Production of Textile Printing, Ministry of Education, Wuhan Textile University, Wuhan 430073, PR China.
authors.forename: Yongming
authors.initials: Y
authors.lastname: Cui
authors.forename: Xiongwei
authors.initials: X
authors.lastname: Dong
authors.forename: Yuguang
authors.initials: Y
authors.lastname: Li
authors.forename: Zuowen
authors.initials: Z
authors.lastname: Li
authors.forename: Wu
authors.initials: W
authors.lastname: Chen
mesh_terms: D001547:Benzaldehydes / Q000737:chemistry*; D018360:Crystallography, X-Ray; D004305:Dose-Response Relationship, Drug; D004791:Enzyme Inhibitors / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D007887:Fabaceae / Q000201:enzymology; D019216:Metals, Heavy / Q000737:chemistry*; D008958:Models, Molecular; D015394:Molecular Structure; D009942:Organometallic Compounds / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D012545:Schiff Bases / Q000737:chemistry*; D013329:Structure-Activity Relationship; D014510:Urease / Q000037:antagonists & inhibitors* / Q000378:metabolism
chemical_list: D001547:Benzaldehydes; D004791:Enzyme Inhibitors; D019216:Metals, Heavy; D009942:Organometallic Compounds; D012545:Schiff Bases; C032892:3,5-dibromosalicylaldehyde; D014510:Urease