title: Impact of differences in glucose tolerance on the prevalence of a negative insulinogenic index.
abstract: OBJECTIVE
  To determine the prevalence of a negative insulinogenic index (change in plasma insulin/change in plasma glucose from 0 to 30 min) from an oral glucose tolerance test according to glucose tolerance category.
  
  
  METHODS
  Data from the San Antonio Heart Study (n=2494), Japanese American Community Diabetes Study (JACDS; n=594) and Genetics of NIDDM Study (n=1519) were examined. Glucose tolerance was defined by ADA criteria.
  
  
  RESULTS
  In the combined cohort, the prevalence of a negative insulinogenic index was significantly higher in diabetes 20/616 (3.2%) compared to normal glucose tolerance 43/2667 (1.6%) (p<0.05). Longitudinally, in the JACDS cohort, the prevalence did not change from baseline (3/594; 0.5%) to 5 (4/505; 0.7%) and 10 years (8/426; 1.9%) (p=0.9) and no subject had a repeat negative insulinogenic index.
  
  
  CONCLUSIONS
  A negative insulinogenic index occurs at a low prevalence across glucose tolerance categories although more often in diabetes, but without recurrence over time.
authors.affiliation: Division of Metabolism, Endocrinology and Nutrition, Department of Medicine, VA Puget Sound Health Care System and University of Washington, Seattle, WA, USA.
authors.forename: Mirjam V
authors.initials: MV
authors.lastname: Faulenbach
authors.forename: Lorena A
authors.initials: LA
authors.lastname: Wright
authors.forename: Carlos
authors.initials: C
authors.lastname: Lorenzo
authors.forename: Kristina M
authors.initials: KM
authors.lastname: Utzschneider
authors.forename: Julia H
authors.initials: JH
authors.lastname: Goedecke
authors.forename: Wilfred Y
authors.initials: WY
authors.lastname: Fujimoto
authors.forename: Edward J
authors.initials: EJ
authors.lastname: Boyko
authors.forename: Marguerite J
authors.initials: MJ
authors.lastname: McNeely
authors.forename: Donna L
authors.initials: DL
authors.lastname: Leonetti
authors.forename: Steven M
authors.initials: SM
authors.lastname: Haffner
authors.forename: Steven E
authors.initials: SE
authors.lastname: Kahn
mesh_terms: D000328:Adult; D000368:Aged; D001213:Asian; D015331:Cohort Studies; D003920:Diabetes Mellitus / Q000097:blood / Q000175:diagnosis* / Q000453:epidemiology / Q000208:ethnology; D005188:False Negative Reactions; D005260:Female; D018149:Glucose Intolerance / Q000097:blood / Q000175:diagnosis* / Q000453:epidemiology / Q000208:ethnology; D005951:Glucose Tolerance Test; D006801:Humans; D007328:Insulin / Q000097:blood* / Q000378:metabolism; D000078790:Insulin Secretion; D050417:Insulin-Secreting Cells / Q000378:metabolism*; D007564:Japan / Q000208:ethnology; D008137:Longitudinal Studies; D008297:Male; D008403:Mass Screening; D008875:Middle Aged; D017410:Practice Guidelines as Topic; D015995:Prevalence; D014481:United States / Q000453:epidemiology
chemical_list: D007328:Insulin