title: Association of Tef polymorphism with depression in Parkinson disease.
abstract: BACKGROUND
  Circadian rhythm disturbance has been implicated in depression, and polymorphisms of circadian genes Cry1, Cry2, and Tef are associated with depression. However, the relationship between these genes and depression symptoms in Parkinson's disease (PD) has not been established.
  
  
  METHODS
  Four hundred eight subjects with PD participated in this study. Demographics, UPDRS, Mini-Mental Status Examination (MMSE), and Hamilton Rating Scale for Depression (HAMD) were obtained in all subjects. Frequency of polymorphisms of Cry1 rs2287161, Cry2 rs10838524, and Tef rs738499 was determined, and the association between genetic polymorphisms of circadian genes and HAMD scores in patients with PD was examined.
  
  
  RESULTS
  Tef, but not Cry1 or Cry2, is associated with HAMD scores in patients with PD in a linear regression model after adjusting for clinical variables (P = 0.004).
  
  
  CONCLUSIONS
  The polymorphism of Tef rs738499 is associated with depression symptoms in PD.
authors.affiliation: Department of Neurology, Affiliated Brain Hospital of Nanjing Medical University, Nanjing, China.
authors.forename: Ping
authors.initials: P
authors.lastname: Hua
authors.forename: Weiguo
authors.initials: W
authors.lastname: Liu
authors.forename: Sheng-Han
authors.initials: SH
authors.lastname: Kuo
authors.forename: Yanyan
authors.initials: Y
authors.lastname: Zhao
authors.forename: Ling
authors.initials: L
authors.lastname: Chen
authors.forename: Ning
authors.initials: N
authors.lastname: Zhang
authors.forename: Chun
authors.initials: C
authors.lastname: Wang
authors.forename: Suwan
authors.initials: S
authors.lastname: Guo
authors.forename: Li
authors.initials: L
authors.lastname: Wang
authors.forename: Hong
authors.initials: H
authors.lastname: Xiao
authors.forename: Justin Y
authors.initials: JY
authors.lastname: Kwan
authors.forename: Tianxia
authors.initials: T
authors.lastname: Wu
mesh_terms: D000368:Aged; D050976:Basic-Leucine Zipper Transcription Factors / Q000235:genetics*; D056931:Cryptochromes / Q000235:genetics; D003863:Depression / Q000209:etiology* / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D056726:Genetic Association Studies; D005838:Genotype; D006801:Humans; D008297:Male; D008609:Mental Status Schedule; D008875:Middle Aged; D010300:Parkinson Disease / Q000150:complications*; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D012720:Severity of Illness Index
chemical_list: D050976:Basic-Leucine Zipper Transcription Factors; C538963:CRY1 protein, human; C538966:CRY2 protein, human; D056931:Cryptochromes; C489490:TEF protein, human