title: Enhanced costimulation by CD70+ B cells aggravates experimental autoimmune encephalomyelitis in autoimmune mice.
abstract: OBJECTIVE
  Assess whether CD70+ B cells contribute to EAE.
  
  
  METHODS
  MOG-specific TCR transgenic mice (2D2) were crossed with mice with constitutive CD70 expression on B cells. The development of EAE and the phenotype of B-T lymphocytes were studied in 2D2xCD70 animals.
  
  
  RESULTS
  Spontaneous EAE developed in 20% of 2D2xCD70 and 3% of 2D2 mice. EAE was also more severe in 2D2xCD70 versus 2D2 animals upon MOG immunization. The susceptibility of 2D2xCD70 to EAE was associated with fewer FoxP3+ T cells.
  
  
  CONCLUSIONS
  Expression of CD70 by B cells aggravates EAE possibly by reducing the number of regulatory T cells.
authors.affiliation: Department of Clinical Immunology and Rheumatology, Academic Medical Center/University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands.
authors.forename: G
authors.initials: G
authors.lastname: Francosalinas
authors.forename: T
authors.initials: T
authors.lastname: Cantaert
authors.forename: M A
authors.initials: MA
authors.lastname: Nolte
authors.forename: P P
authors.initials: PP
authors.lastname: Tak
authors.forename: R A W
authors.initials: RA
authors.lastname: van Lier
authors.forename: D L
authors.initials: DL
authors.lastname: Baeten
mesh_terms: D000818:Animals; D016175:B-Lymphocyte Subsets / Q000276:immunology* / Q000378:metabolism / Q000473:pathology*; D053282:CD27 Ligand / Q000096:biosynthesis* / Q000235:genetics; D004195:Disease Models, Animal; D004681:Encephalomyelitis, Autoimmune, Experimental / Q000235:genetics / Q000276:immunology* / Q000473:pathology; D005260:Female; D016130:Immunophenotyping; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008822:Mice, Transgenic; D050378:T-Lymphocytes, Regulatory / Q000276:immunology / Q000378:metabolism / Q000473:pathology
chemical_list: D053282:CD27 Ligand