title: Protective effect of dexpanthenol on ischemia-reperfusion-induced renal injury in rats.
abstract: OBJECTIVE
  This experimental study was designed to investigate protective and therapeutic effects of Dexpanthenol (Dxp), an alcoholic analogue of pantothenic acid, on kidney damage induced by ischemia-reperfusion (I/R) in rats.
  
  
  METHODS
  Forty rats were randomly divided into a control group and 4 I/R groups (1 h ischemia followed by 23 h reperfusion). Three I/R groups were treated by Dxp (500 mg/kg, i.p.) at 3 different time points (before ischemia, during ischemia and late reperfusion). The histopathological findings including apoptotic changes, and also tissue malondialdehyde (MDA), superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPX), blood urea nitrogen (BUN), serum creatinine (Cr) and albumin (Alb) levels were determined.
  
  
  RESULTS
  Kidney tissue MDA levels were found to be significantly higher in the I/R group, whereas the values of GPX were lower when compared to the control group. The levels of SOD and CAT did not reach to statistical meaning level in I/R group. Dxp given during ischemia reduced the elevated MDA levels to the nearly control levels and this ameliorating effect was found as parallel to the result of GPX. Serum levels of BUN and Cr were significantly higher in I/R group. Dxp given during ischemia significantly reduced the elevated BUN and Cr levels when compared to I/R group. Renal I/R injury also induced extensive tubular necrosis, glomerular damage and apoptosis in the histological evaluation. Dxp ameliorated these histological damages in different amounts in all treatment groups.
  
  
  CONCLUSIONS
  In this study the protective effects of Dxp against renal I/R injury has been evaluated for the first time.
authors.affiliation: Department of Urology, Medical Faculty, Inonu University, Malatya, Turkey. altintasramazan@yahoo.com
authors.forename: Ramazan
authors.initials: R
authors.lastname: Altintas
authors.forename: Hakan
authors.initials: H
authors.lastname: Parlakpinar
authors.forename: Ali
authors.initials: A
authors.lastname: Beytur
authors.forename: Nigar
authors.initials: N
authors.lastname: Vardi
authors.forename: Alaadin
authors.initials: A
authors.lastname: Polat
authors.forename: Mustafa
authors.initials: M
authors.lastname: Sagir
authors.forename: Gul Pelin
authors.initials: GP
authors.lastname: Odabas
mesh_terms: D000818:Animals; D001806:Blood Urea Nitrogen; D002374:Catalase / Q000378:metabolism; D003404:Creatinine / Q000097:blood; D005979:Glutathione Peroxidase / Q000378:metabolism; D007668:Kidney / Q000098:blood supply* / Q000293:injuries* / Q000378:metabolism; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D023421:Models, Animal; D010205:Pantothenic Acid / Q000031:analogs & derivatives* / Q000627:therapeutic use; D051381:Rats; D017208:Rats, Wistar; D015427:Reperfusion Injury / Q000378:metabolism* / Q000517:prevention & control*; D013482:Superoxide Dismutase / Q000378:metabolism
chemical_list: D010205:Pantothenic Acid; C007288:dexpanthenol; D008315:Malondialdehyde; D003404:Creatinine; D002374:Catalase; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase