title: Order from chaos in the nucleus.
abstract: Although it might appear that chromatin is randomly packed within the nucleus, recent data (Hou et al., 2012, in this issue of Molecular Cell) show that it is organized into defined and functionally important domains marked by preferred intradomain physical contacts, and with boundaries associated with insulator protein occupancy.
authors.affiliation: Laboratory of Molecular Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
authors.forename: Zhixiong
authors.initials: Z
authors.lastname: Xu
authors.forename: Gary
authors.initials: G
authors.lastname: Felsenfeld