title: One-step synthesis of novel glycosyltransferase inhibitors.
abstract: A one-step synthesis of two 5-CF(3) UDP-sugars is reported. These non-natural sugar-nucleotides are micromolar inhibitors of two different galactosyltransferases.
authors.affiliation: Institute of Pharmaceutical Science, School of Biomedical Sciences, King's College London, London, UK.
authors.forename: Andrew
authors.initials: A
authors.lastname: Evitt
authors.forename: Lauren M
authors.initials: LM
authors.lastname: Tedaldi
authors.forename: Gerd K
authors.initials: GK
authors.lastname: Wagner
mesh_terms: D020134:Catalytic Domain / Q000187:drug effects; D004791:Enzyme Inhibitors / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D016695:Glycosyltransferases / Q000037:antagonists & inhibitors* / Q000378:metabolism; D015394:Molecular Structure; D013329:Structure-Activity Relationship; D014531:Uridine Diphosphate Galactose / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D004791:Enzyme Inhibitors; D014531:Uridine Diphosphate Galactose; D016695:Glycosyltransferases