title: Tin-mesoporphyrin in the treatment of refractory hyperbilirubinemia due to Rh incompatibility.
abstract: We describe the use of tin-mesoporphyrin (SnMP) in the treatment of an infant with Rh hemolytic disease. The infant's hyperbilirubinemia responded to phototherapy but every time the phototherapy was discontinued, the serum bilirubin rebounded and repeat phototherapy was necessary. A single intramuscular dose of SnMP on day 18 eliminated the need for further phototherapy and allowed us to discharge this infant.
authors.affiliation: Division of Neonatology, Department of Pediatrics, Oakland University William Beaumont School of Medicine, Beaumont Children's Hospital, Royal Oak, MI, USA. jmaisels@beaumont.edu
authors.forename: M J
authors.initials: MJ
authors.lastname: Maisels
authors.forename: H
authors.initials: H
authors.lastname: Yang
mesh_terms: D000328:Adult; D003131:Combined Modality Therapy; D004791:Enzyme Inhibitors / Q000627:therapeutic use*; D004899:Erythroblastosis, Fetal / Q000188:drug therapy*; D006419:Heme Oxygenase (Decyclizing) / Q000037:antagonists & inhibitors*; D006801:Humans; D006932:Hyperbilirubinemia; D008297:Male; D008665:Metalloporphyrins / Q000627:therapeutic use*; D019233:Retreatment
chemical_list: D004791:Enzyme Inhibitors; D008665:Metalloporphyrins; C055421:tin mesoporphyrin; D006419:Heme Oxygenase (Decyclizing)