title: In vitro antimicrobial activities of cinnamon bark oil, anethole, carvacrol, eugenol and guaiazulene against Mycoplasma hominis clinical isolates.
abstract: OBJECTIVE
  The aim of this study was to evaluate the antimicrobial effects of five natural substances against 50 clinical isolates of Mycoplasma hominis.
  
  
  RESULTS
  The in vitro activity of selected natural compounds, cinnamon bark oil, anethole, carvacrol, eugenol and guaiazulene, was investigated against 50 M. hominis isolates cultivated from cervical swabs by the broth dilution method. All showed valuable antimicrobial activity against the tested isolates. Oil from the bark of Cinnamomum zeylanicum (MBC90 = 500 µg/mL) however was found to be the most effective. Carvacrol (MBC90 = 600 µg/mL) and eugenol (MBC90 = 1000 µg/mL) also possessed strong antimycoplasmal activity.
  
  
  CONCLUSIONS
  The results indicate that cinnamon bark oil, carvacrol and eugenol have strong antimycoplasmal activity and the potential for use as antimicrobial agents in the treatment of mycoplasmal infections.
authors.affiliation: Department of Biology and Biochemistry, Faculty of Chemical Technology, University of Pardubice, Pardubice, Czech Republic.
authors.forename: Radek
authors.initials: R
authors.lastname: Sleha
authors.forename: Petra
authors.initials: P
authors.lastname: Mosio
authors.forename: Marketa
authors.initials: M
authors.lastname: Vydrzalova
authors.forename: Alexandra
authors.initials: A
authors.lastname: Jantovska
authors.forename: Vanda
authors.initials: V
authors.lastname: Bostikova
authors.forename: Jaroslava
authors.initials: J
authors.lastname: Mazurova
mesh_terms: D000081248:Allylbenzene Derivatives; D000840:Anisoles / Q000494:pharmacology*; D052176:Azulenes / Q000494:pharmacology*; D000081007:Cymenes; D005054:Eugenol / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D039821:Monoterpenes / Q000494:pharmacology*; D019535:Mycoplasma hominis / Q000187:drug effects*; D009822:Oils, Volatile / Q000494:pharmacology*; D012717:Sesquiterpenes / Q000494:pharmacology*; D045789:Sesquiterpenes, Guaiane
chemical_list: D000081248:Allylbenzene Derivatives; D000840:Anisoles; D052176:Azulenes; D000081007:Cymenes; D039821:Monoterpenes; D009822:Oils, Volatile; D012717:Sesquiterpenes; D045789:Sesquiterpenes, Guaiane; C510046:cinnamon oil, bark; C004451:guaiazulene; D005054:Eugenol; C073316:carvacrol; C006578:anethole