title: Chemorheology of phenylboronate-salicylhydroxamate crosslinked hydrogel networks with a sulfonated polymer backbone.
abstract: Hydrogel networks crosslinked with polymer-bound phenylboronic acid (PBA) and salicylhydroxamic acid (SHA) demonstrate pH-reversible gel behavior due to the pH-dependent equilibrium of the crosslinking moieties that form the gel network. Furthermore, the pH at which gels behave dynamically can be controlled by use of a polyelectrolyte backbone. Here we report on the frequency-dependent chemorheological characterization of PBA-SHA crosslinked hydrogel networks with a sulfonated polymer backbone. Our results suggest that the anionic nature of the polymers allows reversible crosslinking at neutral pH that an otherwise neutral-backboned PBA-SHA crosslinked network cannot, and that these charge-induced dynamics can be effectively screened by ions in solution. Moreover, moduli-frequency data can effectively be reduced into a single master curve with a neutral-backboned PBA-SHA gel data set as the reference condition.
authors.affiliation: University of Utah, Department of Bioengineering and Department of Pharmaceutics and Pharmaceutical Chemistry, 20 S 2030 E Room 108, Salt Lake City, Utah 84112.
authors.forename: Meredith C
authors.initials: MC
authors.lastname: Roberts
authors.forename: Alamelu
authors.initials: A
authors.lastname: Mahalingam
authors.forename: Melissa C
authors.initials: MC
authors.lastname: Hanson
authors.forename: Patrick F
authors.initials: PF
authors.lastname: Kiser