title: Local thrombolysis for patients of severe cerebral venous sinus thrombosis during puerperium.
abstract: OBJECTIVE
  To explore and evaluate the efficacy of intrasinus thrombolysis (IST) in patients with cerebral venous sinus thrombosis (CVST) during postpartum period.
  
  
  METHODS
  11 patients during postpartum period with CVST who received IST during July 2007-November 2011 were included. Urokinase was infused into the sinuses via a microcatheter. Magnetic resonance venography (MRV) was performed to assess the recanalization of venous sinuses.
  
  
  RESULTS
  Before discharge, the intracranial pressure in 11 patients was under 200 mmH(2)O. MRV confirmed that venous sinus of 9 patients were smooth. The cortex venous and deep venous recovered to normal. Venous sinus of 2 patients recanalized partly, and cortex venous and deep venous had compensation. 9 patients had good outcome and 2 patients had only mild deficits.
  
  
  CONCLUSIONS
  Intrasinus thrombolysis is safe and effective in patients with severe cerebral venous sinus thrombosis during postpartum period.
authors.affiliation: Department of Interventional Radiology, The First Affiliated Hospital of Zhengzhou University, 1 Jianshe Road, Zhengzhou 450052, China. gxb3906080@sina.com
authors.forename: Xin-Bin
authors.initials: XB
authors.lastname: Guo
authors.forename: Zhenqiang
authors.initials: Z
authors.lastname: Fu
authors.forename: Lai-Jun
authors.initials: LJ
authors.lastname: Song
authors.forename: Sheng
authors.initials: S
authors.lastname: Guan
mesh_terms: D000328:Adult; D002550:Cerebral Veins / Q000000981:diagnostic imaging*; D002561:Cerebrovascular Disorders / Q000000981:diagnostic imaging / Q000188:drug therapy*; D005343:Fibrinolytic Agents / Q000008:administration & dosage; D006801:Humans; D057967:Infusions, Intraventricular; D008297:Male; D010690:Phlebography; D049590:Postpartum Period; D011644:Puerperal Disorders / Q000000981:diagnostic imaging / Q000188:drug therapy*; D015912:Thrombolytic Therapy / Q000379:methods*; D016896:Treatment Outcome; D014568:Urokinase-Type Plasminogen Activator / Q000008:administration & dosage*; D020246:Venous Thrombosis / Q000000981:diagnostic imaging / Q000188:drug therapy*; D055815:Young Adult
chemical_list: D005343:Fibrinolytic Agents; D014568:Urokinase-Type Plasminogen Activator