title: A multimodal, β-amyloid-targeted contrast agent.
abstract: A multimodal, β-amyloid-targeted contrast agent was synthesized and studied in vitro. The agent has a higher relaxivity than a clinically approved contrast agent and interacts with β-amyloid aggregates producing changes in relaxation rate and fluorescence emission.
authors.affiliation: Department of Chemistry, Wayne State University, 5101 Cass Avenue, Detroit, MI 48202, USA.
authors.forename: Sashiprabha M
authors.initials: SM
authors.lastname: Vithanarachchi
authors.forename: Matthew J
authors.initials: MJ
authors.lastname: Allen
mesh_terms: D000544:Alzheimer Disease / Q000000981:diagnostic imaging; D000682:Amyloid / Q000737:chemistry / Q000378:metabolism*; D003287:Contrast Media / Q000737:chemistry*; D056831:Coordination Complexes / Q000737:chemistry; D005456:Fluorescent Dyes / Q000737:chemistry; D005682:Gadolinium / Q000737:chemistry; D006801:Humans; D008279:Magnetic Resonance Imaging; D011859:Radiography
chemical_list: D000682:Amyloid; D003287:Contrast Media; D056831:Coordination Complexes; D005456:Fluorescent Dyes; D005682:Gadolinium