title: Task difficulty manipulation reveals multiple demand activity but no frontal lobe hierarchy.
abstract: It has been proposed that task control is functionally implemented by a distributed frontoparietal system. It has been argued that one component of this system, the lateral frontal cortex, is functionally organized through a caudal to rostral gradient. Here, we tested 2 competing models, the Information Cascade and Rule Abstraction hypotheses, which suggest different principles underlying the rostrocaudal gradient. We presented participants with 4 vertical lines on a screen and asked them to indicate the position of the shortest line. We manipulated the difficulty of the task in 3 simple ways: By increasing the number of lines, by decreasing the difference between short and normal line length, and by changing the stimulus-response mapping. As expected, these manipulations evoked widespread frontoparietal activation, with activity much more anterior than predicted by Information Cascade and Rule Abstraction models. There were also striking individual differences in the rostrocaudal extent of activity. The results suggest an integrated frontoparietal system, which can be recruited as a whole even by very simple task demands.
authors.affiliation: MRC Cognition and Brain Sciences Unit, Cambridge, UK.
authors.forename: Ben M
authors.initials: BM
authors.lastname: Crittenden
authors.forename: John
authors.initials: J
authors.lastname: Duncan
mesh_terms: D000293:Adolescent; D000328:Adult; D001921:Brain / Q000502:physiology*; D001931:Brain Mapping; D004192:Discrimination, Psychological / Q000502:physiology; D005260:Female; D005625:Frontal Lobe / Q000502:physiology*; D006801:Humans; D008297:Male; D008959:Models, Neurological; D009483:Neuropsychological Tests; D010296:Parietal Lobe / Q000502:physiology; D010775:Photic Stimulation; D011930:Reaction Time; D013647:Task Performance and Analysis; D013850:Thinking / Q000502:physiology*; D014796:Visual Perception / Q000502:physiology; D055815:Young Adult
keywords: Information Cascade; Rule Abstraction; functional magnetic resonance imaging; multiple demand; prefrontal cortex