title: Nausea and vomiting after ENT surgeries: A comparison between ondansetron, metoclopramide and small dose of propofol.
abstract: OBJECTIVE
  To evaluate the antiemetic efficacy of ondansetron, metoclopramide or small dose of propofol following ear, nose and throat (ENT) surgery.
  
  
  METHODS
  A prospective randomized study involving 60 patients, both children and adults undergoing elective ENT surgery under standard general anesthesia. At the completion of surgery the patients received either 0.1 mg/kg of ondansetron or 0.2 mg/kg of metoclopramide or 0.5 mg/kg of propofol intravenously. The patients were observed for 24 hrs after operation for any occurrence of nausea and vomiting.
  
  
  RESULTS
  The incidence of postoperative nausea and vomiting (PONV) during first 24 hrs was recorded in 20%, 70%, 50% of patients who had received ondansetron, metoclopr-amide or propofol respectively (p < 0.05). Fewer patients given ondansetron needed rescue antiemetic. The incidence of PONV was higher following middle year surgery.
  
  
  CONCLUSIONS
  It was concluded that ondansetron was most effective in preventing occurrence of PONV while metoclopramide was least effective. Propofol was effective only in 50% of patients, thus not recommended for routine use.
authors.affiliation: Department of Anaesthesiology and Critical Care and Department of ENT, S. N. Medical College, Agra, UP India.
authors.forename: Abhijeet Rajan
authors.initials: AR
authors.lastname: Mishra
authors.forename: Uma
authors.initials: U
authors.lastname: Srivastava
authors.forename: Dharmendra
authors.initials: D
authors.lastname: Kumar
authors.forename: Namita
authors.initials: N
authors.lastname: Saraswat
authors.forename: Aditya
authors.initials: A
authors.lastname: Kumar
authors.forename: Yashwant S
authors.initials: YS
authors.lastname: Payal
authors.forename: Amrita
authors.initials: A
authors.lastname: Gupta
authors.forename: Ankit
authors.initials: A
authors.lastname: Darolia
keywords: Ear, nose and throat surgery; Metoclopramide; Ondansetron; Postoperative nausea and vomiting; Propofol