title: Response to therapy following retreatment of serofast early syphilis patients with benzathine penicillin.
abstract: Persistent nontreponemal titers after treatment are common among patients with early syphilis. We retreated 82 human immunodeficiency virus-negative early syphilis participants who were serofast at 6 months using benzathine penicillin. Only 27% exhibited serological response after retreatment and after an additional 6 months of follow-up.
authors.affiliation: Division of Infectious Diseases, Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA. idrod@med.unc.edu
authors.forename: Arlene C
authors.initials: AC
authors.lastname: Seña
authors.forename: Mark
authors.initials: M
authors.lastname: Wolff
authors.forename: Frieda
authors.initials: F
authors.lastname: Behets
authors.forename: Kathleen
authors.initials: K
authors.lastname: Van Damme
authors.forename: David H
authors.initials: DH
authors.lastname: Martin
authors.forename: Peter
authors.initials: P
authors.lastname: Leone
authors.forename: Linda
authors.initials: L
authors.lastname: McNeil
authors.forename: Edward W
authors.initials: EW
authors.lastname: Hook
mesh_terms: D000293:Adolescent; D000328:Adult; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010401:Penicillin G Benzathine / Q000627:therapeutic use*; D019233:Retreatment; D013587:Syphilis / Q000188:drug therapy*; D013588:Syphilis Serodiagnosis; D013997:Time Factors; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D000900:Anti-Bacterial Agents; D010401:Penicillin G Benzathine