title: Clustering of inflammatory biomarkers and risk of hypertension in a Mongolian population in China.
abstract: OBJECTIVE
  There is little knowledge on whether there is clustering of inflammatory biomarkers, such as C-reactive protein (CRP), soluble intracellular adhesion molecule1-1 (sICAM-1), and angiotensin II (Ang II), in individuals with hypertension in the Mongolian population. In the present study, we investigated this relationship in a Mongolian population in China.
  
  
  METHODS
  A total of 2589 adult Mongolians, aged 20 years and older, were recruited as study participants. Data on demographics, lifestyle, family history of hypertension, blood pressure, and blood chemistry were collected, and inflammatory biomarkers were measured in all participants.
  
  
  RESULTS
  The proportion of subjects with increased levels of two or three biomarkers was significantly higher in those with hypertension (21.0% and 6.0%, respectively) than in those with prehypertension (12.7% and 0.5%, respectively) or normotension (8.1% and 0.2%, respectively). The multivariate adjusted odds ratios (95% confidence interval) of hypertension associated with increased levels of one, two or three biomarkers were 0.94 (0.72-1.22), 1.42 (0.93-2.16), and 11.08 (1.45-84.80), respectively, compared with subjects with no increase in any biomarker.
  
  
  CONCLUSIONS
  Hypertension was associated with a cluster of inflammatory biomarkers in the Mongolian population.
authors.forename: Xiao Hong
authors.initials: XH
authors.lastname: Zhu
authors.forename: Yang
authors.initials: Y
authors.lastname: Jiao
authors.forename: Hong Mei
authors.initials: HM
authors.lastname: Li
authors.forename: Ai Li
authors.initials: AL
authors.lastname: Wang
authors.forename: Gui Yan
authors.initials: GY
authors.lastname: Wang
authors.forename: Wei Jun
authors.initials: WJ
authors.lastname: Tong
authors.forename: Yong Hong
authors.initials: YH
authors.lastname: Zhang
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000804:Angiotensin II / Q000235:genetics / Q000378:metabolism; D044466:Asian People; D002097:C-Reactive Protein / Q000235:genetics / Q000378:metabolism; D002681:China; D005260:Female; D005819:Genetic Markers; D020022:Genetic Predisposition to Disease; D006801:Humans; D006973:Hypertension / Q000235:genetics*; D007249:Inflammation / Q000235:genetics / Q000378:metabolism*; D018799:Intercellular Adhesion Molecule-1 / Q000235:genetics / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D055815:Young Adult
chemical_list: D005819:Genetic Markers; C573420:ICAM1 protein, human; D000804:Angiotensin II; D018799:Intercellular Adhesion Molecule-1; D002097:C-Reactive Protein