title: Negative prognostic factors in colorectal carcinoma: An analysis of 448 patients.
abstract: OBJECTIVE
  Colorectal carcinoma (CRC) is the most frequent malignancy of the gastrointestinal tract. Prognostic researches are carried out for choosing the optimum therapy, evaluating therapy results and comparing multicentre results for better qualification in the therapy of the disease.
  
  
  METHODS
  In this study, 448 patients, whose surgery and follow-up was performed by the same correspondent surgeon between the years 1995 and 2003, were retrospectively analyzed.
  
  
  RESULTS
  Age, presence of comorbidity, weight loss, emergency admission, high serum CEA and CA 19-9 levels, neighboring organ invasion, operation type, major morbidity, tumor size and type, lymph node metastases, venous and perineural invasion, Dukes' classification and local recurrence and distant metastasis during follow-up are found to be significant negative factors affecting prognosis of the CRC patient.
  
  
  CONCLUSIONS
  Therapy results of the CRC are evaluated by survival times regardless of the therapy method selected for each individual. In our study we tried to find out negative prognostic factors by researching possible factors affecting disease free survival time for CRC. Since our understanding of factors that have an impact on prognosis increases, we are hoping to improve survival.
authors.affiliation: Department of General Surgery/Division of Proctology, School of Medicine, Ege University, Turkey Izmir.
authors.forename: Cemil
authors.initials: C
authors.lastname: Caliskan
authors.forename: Necdet
authors.initials: N
authors.lastname: Guler
authors.forename: Can
authors.initials: C
authors.lastname: Karaca
authors.forename: Ozer
authors.initials: O
authors.lastname: Makay
authors.forename: Ozgur
authors.initials: O
authors.lastname: Firat
authors.forename: Mustafa A
authors.initials: MA
authors.lastname: Korkut
keywords: Colorectal cancer; Prognosis; Survive