title: Regulation of angiogenesis by hypoxia: the role of microRNA.
abstract: Understanding the cellular pathways that regulate angiogenesis during hypoxia is a necessary aspect in the development of novel treatments for cardiovascular disorders. Although the pathways of angiogenesis have been extensively studied, there is limited information on the role of miRNAs in this process. miRNAs or their antagomirs could be used in future therapeutic approaches to regulate hypoxia-induced angiogenesis, so it is critical to understand their role in governing angiogenesis during hypoxic conditions. Although hypoxia and ischemia change the expression profile of many miRNAs, a functional role for a limited number of so-called hypoxamiRs has been demonstrated in angiogenesis. Here, we discuss the best examples that illustrate the role of hypoxamiRs in angiogenesis.
authors.affiliation: Department of Biology and Pharmaceutical Botany, Medical University of Gdansk, Poland.
authors.forename: Piotr
authors.initials: P
authors.lastname: Madanecki
authors.forename: Niren
authors.initials: N
authors.lastname: Kapoor
authors.forename: Zsuzsa
authors.initials: Z
authors.lastname: Bebok
authors.forename: Renata
authors.initials: R
authors.lastname: Ochocka
authors.forename: James F
authors.initials: JF
authors.lastname: Collawn
authors.forename: Rafal
authors.initials: R
authors.lastname: Bartoszewski
mesh_terms: D020413:3' Untranslated Regions / Q000235:genetics; D002318:Cardiovascular Diseases / Q000235:genetics* / Q000378:metabolism; D015687:Cell Hypoxia; D045744:Cell Line, Tumor; D042783:Endothelial Cells / Q000378:metabolism / Q000473:pathology; D005786:Gene Expression Regulation; D006801:Humans; D000860:Hypoxia / Q000235:genetics* / Q000378:metabolism; D051795:Hypoxia-Inducible Factor 1, alpha Subunit / Q000235:genetics / Q000378:metabolism; D035683:MicroRNAs / Q000235:genetics* / Q000378:metabolism; D009369:Neoplasms / Q000098:blood supply* / Q000235:genetics / Q000378:metabolism; D009389:Neovascularization, Pathologic; D015398:Signal Transduction; D042461:Vascular Endothelial Growth Factor A / Q000235:genetics / Q000378:metabolism
chemical_list: D020413:3' Untranslated Regions; C497442:HIF1A protein, human; D051795:Hypoxia-Inducible Factor 1, alpha Subunit; D035683:MicroRNAs; C467484:VEGFA protein, human; D042461:Vascular Endothelial Growth Factor A