title: Bacterial sensor kinases using Fe-S cluster binding PAS or GAF domains for O2 sensing.
abstract: [4Fe-4S](2+) clusters are used by very diverse types of bacterial sensors for response to oxygen, including DNA-binding proteins of the CRP/FNR family and sensor kinases like NreB. In NreB the cluster is bound by an input domain of the PAS type. The [4Fe-4S](2+) cluster of NreB responds to O(2) by degradation to a [2Fe-2S](2+) cluster which is labile and decomposes. NreB constitutes together with AirS the NreB/AirS family of bacterial sensor kinases that contain PAS or GAF domains for binding of [4Fe-4S](2+) or [2Fe-2S](2+) clusters and oxygen sensing. The NreB/AirS family is related to the FixL sensor kinases that use hemeB binding PAS domains for oxygen sensing.
authors.affiliation: Institute for Microbiology and Wine Research, University of Mainz, Mainz, Germany. unden@uni-mainz.de
authors.forename: Gottfried
authors.initials: G
authors.lastname: Unden
authors.forename: Stephanie
authors.initials: S
authors.lastname: Nilkens
authors.forename: Mareike
authors.initials: M
authors.lastname: Singenstreu
mesh_terms: D000595:Amino Acid Sequence; D001419:Bacteria / Q000201:enzymology*; D007501:Iron / Q000378:metabolism*; D008969:Molecular Sequence Data; D010100:Oxygen / Q000378:metabolism*; D010770:Phosphotransferases / Q000737:chemistry* / Q000378:metabolism*; D017434:Protein Structure, Tertiary; D013455:Sulfur / Q000378:metabolism*
chemical_list: D013455:Sulfur; D007501:Iron; D010770:Phosphotransferases; D010100:Oxygen