title: Up-regulation of microRNA-1290 impairs cytokinesis and affects the reprogramming of colon cancer cells.
abstract: Abnormal cytokinesis increases the possibility of nuclear fusion in tumor cells. However, the role of microRNAs (miRNAs) in abnormal cytokinesis is unclear. Here, we found that miR-1290 was significantly up-regulated in clinical colon cancer tissues. Up-regulation of miR-1290 postponed cytokinesis and led to the formation of multinucleated cells. KIF13B was a target of miR-1290 that was involved in aberrant cytokinesis. Furthermore, enforced expression of miR-1290 activated the Wnt pathway and increased the reprogramming-related transcript factors c-Myc and Nanog. Our results suggest that up-regulation of miR-1290 in colon cancer cells impaired cytokinesis and affected reprogramming.
authors.affiliation: Laboratory of Gastroenterology, Second Affiliated Hospital of Zhejiang University, School of Medicine, Hangzhou, Zhejiang Province 310009, China.
authors.forename: Jia
authors.initials: J
authors.lastname: Wu
authors.forename: Xiaowei
authors.initials: X
authors.lastname: Ji
authors.forename: Linlin
authors.initials: L
authors.lastname: Zhu
authors.forename: Qiaoli
authors.initials: Q
authors.lastname: Jiang
authors.forename: Zhenzhen
authors.initials: Z
authors.lastname: Wen
authors.forename: Song
authors.initials: S
authors.lastname: Xu
authors.forename: Wei
authors.initials: W
authors.lastname: Shao
authors.forename: Jianting
authors.initials: J
authors.lastname: Cai
authors.forename: Qin
authors.initials: Q
authors.lastname: Du
authors.forename: Yongliang
authors.initials: Y
authors.lastname: Zhu
authors.forename: Jianshan
authors.initials: J
authors.lastname: Mao
mesh_terms: D000236:Adenoma / Q000235:genetics / Q000378:metabolism / Q000473:pathology*; D001483:Base Sequence; D001665:Binding Sites; D045744:Cell Line, Tumor; D048750:Cell Nucleus Division; D049109:Cell Proliferation; D003110:Colonic Neoplasms / Q000235:genetics / Q000378:metabolism / Q000473:pathology*; D048749:Cytokinesis / Q000235:genetics*; D015972:Gene Expression Regulation, Neoplastic; D018398:Homeodomain Proteins / Q000378:metabolism; D006801:Humans; D016547:Kinesins / Q000235:genetics / Q000378:metabolism; D035683:MicroRNAs / Q000235:genetics* / Q000378:metabolism / Q000502:physiology; D016328:NF-kappa B / Q000378:metabolism; D000071317:Nanog Homeobox Protein; D051057:Proto-Oncogene Proteins c-akt / Q000378:metabolism; D016271:Proto-Oncogene Proteins c-myc / Q000378:metabolism; D034622:RNA Interference; D014158:Transcription, Genetic; D015854:Up-Regulation; D060449:Wnt Signaling Pathway
chemical_list: D018398:Homeodomain Proteins; C574604:MIRN1290 microRNA, human; C489427:MYC protein, human; D035683:MicroRNAs; C486780:NANOG protein, human; D016328:NF-kappa B; D000071317:Nanog Homeobox Protein; D016271:Proto-Oncogene Proteins c-myc; D051057:Proto-Oncogene Proteins c-akt; C513406:KIF13B protein, human; D016547:Kinesins