title: Pathogenesis of African swine fever in domestic pigs and European wild boar.
abstract: African swine fever (ASF) is among the most important viral diseases that can affect domestic and feral pigs. Both clinical signs and pathomorphological changes vary considerably depending on strain virulence and host factors. Acute infections with highly virulent virus strains lead to a clinical course that resembles a viral haemorrhagic fever that is characterized by pronounced depletion of lymphoid tissues, apoptosis of lymphocyte subsets, and impairment of haemostasis and immune functions. It is generally accepted that most lesions can be attributed to cytokine-mediated interactions triggered by infected and activated monocytes and macrophages, rather than by virus-induced direct cell damage. Nevertheless, most pathogenetic mechanisms are far from being understood. This review summarizes the current knowledge and discusses implications and research gaps.
authors.affiliation: Institute of Diagnostic Virology, Friedrich-Loeffler-Institut, Suedufer 10, 17493 Greifswald-Insel Riems, Germany. sandra.blome@fli.bund.de
authors.forename: Sandra
authors.initials: S
authors.lastname: Blome
authors.forename: Claudia
authors.initials: C
authors.lastname: Gabriel
authors.forename: Martin
authors.initials: M
authors.lastname: Beer
mesh_terms: D000357:African Swine Fever / Q000276:immunology* / Q000473:pathology* / Q000821:virology; D000358:African Swine Fever Virus / Q000276:immunology* / Q000472:pathogenicity*; D000818:Animals; D054884:Host-Pathogen Interactions; D007107:Immune System / Q000473:pathology* / Q000503:physiopathology*; D034421:Sus scrofa; D013552:Swine