title: Reversible α-helix formation controlled by a hydrogen bond surrogate.
abstract: Strategically placed covalent linkages have been shown to stabilize helical conformations in short peptide sequences. Here we report the synthesis of a stabilized α-helix that utilizes an internal disulfide linkage. Structural analysis indicates that the dynamic nature of the disulfide bridge allows for the reversible formation of an α-helix through oxidation and reduction reactions.
authors.affiliation: Department of Chemistry, New York University, New York, NY 10003, USA.
authors.forename: Stephen E
authors.initials: SE
authors.lastname: Miller
authors.forename: Neville R
authors.initials: NR
authors.lastname: Kallenbach
authors.forename: Paramjit S
authors.initials: PS
authors.lastname: Arora