title: Is there a relationship between lipids metabolism and splenic surgeries?
abstract: OBJECTIVE
  To assess the influence of spleen surgeries (splenectomy, presence of spleen and after conservative surgeries) on lipids metabolism.
  
  
  METHODS
  Fifty female Wistar rats of similar weight and age were divided into five groups submitted to the following procedures: Group 1 - control, with an intact spleen; Group 2 - sham operation, Group 3 - total splenectomy; Group 4 - subtotal splenectomy, and Group 5 - total splenectomy complemented with autogenous spleen tissue implants. Four months after the interventions, serum triglycerides, total cholesterol and fractions (VLDL-cholesterol, LDL-cholesterol, HDL-cholesterol) were determined. The results for the four groups were compared by analysis of variance followed by the Tukey-Kramer test, with the level of significance set at p<0.05.
  
  
  RESULTS
  There were no differences between groups 1, 2, 4 and 5. In the animals submitted to total splenectomy, total cholesterol (p=0.0151) and LDL-cholesterol fraction concentrations (p<0.0001) were higher, whereas HDL-cholesterol fraction concentrations were lower (p=0.0026) than those detected in the other groups. There was no difference in triglycerides (p=0.1571) or VLDL-cholesterol (p=0.2527) between groups.
  
  
  CONCLUSIONS
  Splenectomy is related to changes in the lipid metabolism that are reverted by autogenous spleen tissue implants.
authors.affiliation: Department of Surgery, UFMG, Belo Horizonte, MG, Brazil. luizronaldoa@yahoo.com.br
authors.forename: Luiz Ronaldo
authors.initials: LR
authors.lastname: Alberti
authors.forename: Denny Fabrício Magalhães
authors.initials: DF
authors.lastname: Veloso
authors.forename: Leonardo de Souza
authors.initials: Lde S
authors.lastname: Vasconcellos
authors.forename: Andy
authors.initials: A
authors.lastname: Petroianu
mesh_terms: D000818:Animals; D001835:Body Weight; D002784:Cholesterol / Q000097:blood; D005260:Female; D050356:Lipid Metabolism; D051381:Rats; D017208:Rats, Wistar; D012016:Reference Values; D013154:Spleen / Q000601:surgery*; D013156:Splenectomy / Q000379:methods*; D013997:Time Factors; D014280:Triglycerides / Q000097:blood
chemical_list: D014280:Triglycerides; D002784:Cholesterol