title: Synthesis of C3-arylated-3-deazauridine derivatives with potent anti-HSV-1 activities.
abstract: A series of 3-deazauridines (3-DU) analogues were synthesized and evaluated in vitro for their antiherpetic activity against HSV-1 on Vero cell lines by cell viability. A first campaign of tests suggested that C3-arylated-3-DU derivatives could constitute a novel family of antiherpetic agents. A second campaign of biological evaluations led to the discovery of two potent anti-HSV-1 agents with comparable activity than acyclovir.
authors.affiliation: Université Bordeaux 1, UMR CNRS 5255, Institut des Sciences Moléculaires, 351 Cours de la Libération, 33405 Talence Cedex, France.
authors.forename: Julien
authors.initials: J
authors.lastname: Lalut
authors.forename: Ludovic
authors.initials: L
authors.lastname: Tripoteau
authors.forename: Christel
authors.initials: C
authors.lastname: Marty
authors.forename: Hugo
authors.initials: H
authors.lastname: Bares
authors.forename: Nathalie
authors.initials: N
authors.lastname: Bourgougnon
authors.forename: François-Xavier
authors.initials: FX
authors.lastname: Felpin
mesh_terms: D015092:3-Deazauridine / Q000031:analogs & derivatives / Q000138:chemical synthesis / Q000494:pharmacology*; D000818:Animals; D000998:Antiviral Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D002470:Cell Survival / Q000187:drug effects; D002522:Chlorocebus aethiops; D004305:Dose-Response Relationship, Drug; D018259:Herpesvirus 1, Human / Q000187:drug effects*; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D013329:Structure-Activity Relationship; D014709:Vero Cells
chemical_list: D000998:Antiviral Agents; D015092:3-Deazauridine