title: Endocytic receptor-mediated control of morphogen signaling.
abstract: Receptor-mediated endocytosis provides a mechanism by which cells take up signaling molecules from the extracellular space. Recent studies have shown that one class of endocytic receptors, the low-density lipoprotein receptor-related proteins (LRPs), is of particular relevance for embryonic development. In this Primer, we describe how LRPs constitute central pathways that modulate morphogen presentation to target tissues and cellular signal reception, and how LRP dysfunction leads to developmental disturbances in many species.
authors.affiliation: Max-Delbrueck-Center for Molecular Medicine, D-13125 Berlin, Germany. willnow@mdc-berlin.de
authors.forename: Thomas E
authors.initials: TE
authors.lastname: Willnow
authors.forename: Annabel
authors.initials: A
authors.lastname: Christ
authors.forename: Annette
authors.initials: A
authors.lastname: Hammes
mesh_terms: D000818:Animals; D002352:Carrier Proteins / Q000378:metabolism*; D050171:Dyslipidemias; D047108:Embryonic Development; D004705:Endocytosis; D006801:Humans; D026502:LDL-Receptor Related Proteins / Q000378:metabolism*; D008074:Lipoproteins / Q000378:metabolism*; D015398:Signal Transduction
chemical_list: D002352:Carrier Proteins; D026502:LDL-Receptor Related Proteins; D008074:Lipoproteins