title: Anti-infective and herbicidal activity of N-substituted 2-aminobenzothiazoles.
abstract: In this study, a series of N-substituted 2-aminobenzothiazoles was prepared according to a recently developed method. Twelve compounds were tested for their activity related to the inhibition of photosynthetic electron transport (PET) in spinach (Spinacia oleracea L.) chloroplasts. Primary in vitro screening of the discussed compounds was also performed against fungal, bacterial and mycobacterial species. The biological activities of some compounds were comparable or higher than the standards phenoxymethylpenicillin or pyrazinamide. The most effective compounds demonstrated insignificant toxicity against the human monocytic leukemia THP-1 cell line. For all compounds, the structure-activity relationships are discussed.
authors.affiliation: Department of Chemical Drugs, Faculty of Pharmacy, University of Veterinary and Pharmaceutical Sciences, Palackeho 1/3, 612 42 Brno, Czech Republic. adagmar@post.cz
authors.forename: Dagmar
authors.initials: D
authors.lastname: Fajkusova
authors.forename: Matus
authors.initials: M
authors.lastname: Pesko
authors.forename: Stanislava
authors.initials: S
authors.lastname: Keltosova
authors.forename: Jiahui
authors.initials: J
authors.lastname: Guo
authors.forename: Zbynek
authors.initials: Z
authors.lastname: Oktabec
authors.forename: Marcela
authors.initials: M
authors.lastname: Vejsova
authors.forename: Peter
authors.initials: P
authors.lastname: Kollar
authors.forename: Aidan
authors.initials: A
authors.lastname: Coffey
authors.forename: Jozef
authors.initials: J
authors.lastname: Csollei
authors.forename: Katarina
authors.initials: K
authors.lastname: Kralova
authors.forename: Josef
authors.initials: J
authors.lastname: Jampilek
mesh_terms: D000890:Anti-Infective Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D000935:Antifungal Agents / Q000378:metabolism / Q000494:pharmacology*; D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D052160:Benzothiazoles / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D045744:Cell Line, Tumor; D002736:Chloroplasts / Q000187:drug effects; D004354:Drug Screening Assays, Antitumor; D006540:Herbicides / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D006801:Humans; D008826:Microbial Sensitivity Tests; D018724:Spinacia oleracea; D013329:Structure-Activity Relationship
chemical_list: D000890:Anti-Infective Agents; D000935:Antifungal Agents; D000970:Antineoplastic Agents; D052160:Benzothiazoles; D006540:Herbicides