title: Relationship between plasma high-mobility group box-1 levels and clinical outcomes of ischemic stroke.
abstract: OBJECTIVE
  High-mobility group box-1 (HMGB1) is regarded as a central mediator of inflammation and involved in many inflammatory diseases. This study aimed to investigate impact of plasma HMGB1 level on 1-year clinical outcomes of ischemic stroke.
  
  
  METHODS
  Plasma HMGB1 levels of 338 patients were quantified by enzyme-linked immunosorbent assay. The end points were mortality and unfavorable outcome (modified Rankin Scale score>2) after 1 year.
  
  
  RESULTS
  Plasma HMGB1 level emerged as an independent predictor of 1-year clinical outcomes. Its prognostic value was similar to National Institutes of Health Stroke Scale score's. It improved prognostic value of National Institutes of Health Stroke Scale score.
  
  
  CONCLUSIONS
  Plasma HMGB1 level represents a novel biomarker for predicting 1-year clinical outcomes of ischemic stroke.
authors.affiliation: Department of Neurology, The First Hospital of Jia Xing, Jiaxing, 314001, PR China. Electronic address: jiaxingjuminghuang@163.com.
authors.forename: Ju-Ming
authors.initials: JM
authors.lastname: Huang
authors.forename: Jin
authors.initials: J
authors.lastname: Hu
authors.forename: Ning
authors.initials: N
authors.lastname: Chen
authors.forename: Min-Lei
authors.initials: ML
authors.lastname: Hu
mesh_terms: D000368:Aged; D015415:Biomarkers / Q000097:blood; D002545:Brain Ischemia / Q000097:blood* / Q000401:mortality / Q000628:therapy*; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D024243:HMGB1 Protein / Q000097:blood*; D006801:Humans; D018836:Inflammation Mediators / Q000097:blood; D008279:Magnetic Resonance Imaging; D008297:Male; D011379:Prognosis; D012307:Risk Factors; D012720:Severity of Illness Index; D020521:Stroke / Q000097:blood* / Q000401:mortality / Q000628:therapy*; D016896:Treatment Outcome
chemical_list: D015415:Biomarkers; D024243:HMGB1 Protein; D018836:Inflammation Mediators
keywords: High mobility group box-1; Ischemic stroke; Outcome