title: Impaired adult myelination in the prefrontal cortex of socially isolated mice.
abstract: Protracted social isolation of adult mice induced behavioral, transcriptional and ultrastructural changes in oligodendrocytes of the prefrontal cortex (PFC) and impaired adult myelination. Social re-integration was sufficient to normalize behavioral and transcriptional changes. Short periods of isolation affected chromatin and myelin, but did not induce behavioral changes. Thus, myelinating oligodendrocytes in the adult PFC respond to social interaction with chromatin changes, suggesting that myelination acts as a form of adult plasticity.
authors.affiliation: Department of Neuroscience and Friedman Brain Institute, Mount Sinai School of Medicine, New York, New York, USA.
authors.forename: Jia
authors.initials: J
authors.lastname: Liu
authors.forename: Karen
authors.initials: K
authors.lastname: Dietz
authors.forename: Jacqueline M
authors.initials: JM
authors.lastname: DeLoyht
authors.forename: Xiomara
authors.initials: X
authors.lastname: Pedre
authors.forename: Dipti
authors.initials: D
authors.lastname: Kelkar
authors.forename: Jasbir
authors.initials: J
authors.lastname: Kaur
authors.forename: Vincent
authors.initials: V
authors.lastname: Vialou
authors.forename: Mary Kay
authors.initials: MK
authors.lastname: Lobo
authors.forename: David M
authors.initials: DM
authors.lastname: Dietz
authors.forename: Eric J
authors.initials: EJ
authors.lastname: Nestler
authors.forename: Jeffrey
authors.initials: J
authors.lastname: Dupree
authors.forename: Patrizia
authors.initials: P
authors.lastname: Casaccia
mesh_terms: D000367:Age Factors; D000818:Animals; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D009186:Myelin Sheath / Q000473:pathology* / Q000648:ultrastructure; D009413:Nerve Fibers, Myelinated / Q000473:pathology* / Q000648:ultrastructure; D009836:Oligodendroglia / Q000473:pathology / Q000648:ultrastructure; D017397:Prefrontal Cortex / Q000473:pathology* / Q000648:ultrastructure; D012934:Social Isolation / Q000523:psychology*