title: Antifungal agents and therapy for infants and children with invasive fungal infections: a pharmacological perspective.
abstract: Invasive fungal infections, although relatively rare, are life-threatening diseases in premature infants and immunocompromised children. While many advances have been made in antifungal therapeutics in the last two decades, knowledge of the pharmacokinetics and pharmacodynamics of antifungal agents for infants and children remains incomplete. This review summarizes the pharmacology and clinical utility of currently available antifungal agents and discusses the opportunities and challenges for future research.
authors.affiliation: Department of Molecular and Clinical Pharmacology, University of Liverpool, Liverpool, UK.
authors.forename: Jodi M
authors.initials: JM
authors.lastname: Lestner
authors.forename: P Brian
authors.initials: PB
authors.lastname: Smith
authors.forename: Michael
authors.initials: M
authors.lastname: Cohen-Wolkowiez
authors.forename: Daniel K
authors.initials: DK
authors.lastname: Benjamin
authors.forename: William W
authors.initials: WW
authors.lastname: Hope
mesh_terms: D000935:Antifungal Agents / Q000627:therapeutic use*; D002648:Child; D002675:Child, Preschool; D006801:Humans; D016867:Immunocompromised Host / Q000187:drug effects; D007223:Infant; D007231:Infant, Newborn; D007234:Infant, Premature; D007235:Infant, Premature, Diseases / Q000188:drug therapy; D009181:Mycoses / Q000188:drug therapy*
chemical_list: D000935:Antifungal Agents