title: Bortezomib-induced bronchiolitis obliterans organizing pneumonia.
abstract: Introduction. Bortezomib is a proteasome inhibitor indicated for the treatment of multiple myeloma patients. The most frequent side effects are gastrointestinal and neurological. Serious pulmonary complications have been described rarely. Observation. This case involves a 74-year-old man suffering from IgG Kappa myeloma treated with bortezomib, melphalan, and dexamethasone. After administering chemotherapy, the patient developed an acute respiratory distress syndrome (ARDS). A surgical pulmonary biopsy proved the existence of bronchiolitis obliterans organizing pneumonia (BOOP) lesions. Systemic corticotherapy led to a rapid improvement in the patient's condition. Conclusion. This is the first reported histologically confirmed case of bortezomid-induced BOOP. Faced with severe respiratory symptoms in the absence of other etiologies, complications due to bortezomid treatment should be evoked and corticotherapy considered.
authors.affiliation: Medical-Surgical Intensive Care Unit, Dupuytren University Hospital, 2 Avenue Martin Luther King, 87000 Limoges, France ; Department of Pulmonology, Dupuytren University Hospital, 2 Avenue Martin Luther King, 87000 Limoges, France.
authors.forename: E
authors.initials: E
authors.lastname: Vandeix
authors.forename: F
authors.initials: F
authors.lastname: Favard
authors.forename: N
authors.initials: N
authors.lastname: Pichon
authors.forename: M
authors.initials: M
authors.lastname: Delage-Corre
authors.forename: B
authors.initials: B
authors.lastname: Melloni
authors.forename: M
authors.initials: M
authors.lastname: Clavel