title: Effect of provenance, plant part and processing on extract profiles from cultivated European Rhodiola rosea L. for medicinal use.
abstract: The demand for plant material of Rhodiola rosea L. (Crassulaceae) for medicinal use has increased recently, amid concerns about its quality and sustainability. We have analysed the content of phenylpropanoids (total rosavins) and salidroside in liquid extracts from 3-year old cultivated plants of European origin, and mapped the influence of plant part (rhizome versus root), genotype, drying, cutting, and extraction solvent to chemical composition. Rhizomes contained 1.5-4 times more salidroside (0.3-0.4% dry wt) and total rosavins (1.2-3.0%) than roots. The qualitative decisive phenylpropanoid content in the extracts was most influenced by plant part, solvent, and genotype, while drying temperature and cutting conditions were of less importance. We have shown that R. rosea from different boreal European provenances can be grown under temperate conditions and identified factors to obtain consistent high quality extracts provided that authentic germplasm is used and distinguished between rhizome, roots and their mixtures.
authors.affiliation: Centre for Pharmacognosy and Phytotherapy, Department for Pharmaceutical and Biological Chemistry, The School of Pharmacy, University College London, London, United Kingdom. wieland.peschel@ema.europa.eu
authors.forename: Wieland
authors.initials: W
authors.lastname: Peschel
authors.forename: José M
authors.initials: JM
authors.lastname: Prieto
authors.forename: Caroline
authors.initials: C
authors.lastname: Karkour
authors.forename: Elizabeth M
authors.initials: EM
authors.lastname: Williamson
mesh_terms: D002851:Chromatography, High Pressure Liquid; D004187:Disaccharides / Q000737:chemistry; D005960:Glucosides / Q000737:chemistry; D009682:Magnetic Resonance Spectroscopy; D010636:Phenols / Q000737:chemistry; D029771:Rhodiola / Q000737:chemistry*
chemical_list: D004187:Disaccharides; D005960:Glucosides; D010636:Phenols; C529148:rosavin; C009172:rhodioloside