title: Ifosfamide-induced neurotoxicity reversal with continuous veno-venous hemodialysis. A case report.
abstract: Ifosfamide is an alkylating agent used to treat different types of malignancies including lymphomas, sarcomas and germinal cell tumors. Symptoms of ifosfamide neurotoxicity can range from mild confusion, dizziness and hallucination to overt encephalopathy. Various treatment options like methylene blue, albumin infusion and rarely hemodialysis have been used to treat ifosfamide neurotoxicity. We hereby report a case of a patient with relapsed diffuse large B cell lymphoma who received methylene blue after experiencing acute renal failure and encephalopathy due to ifosfamide with no improvement. The prompt use of hemodialysis in this case has led to reversal of both renal failure and neurotoxicity.
authors.affiliation: Department of Medicine, Hematology Oncology Section, Oklahoma University, OK 73104, USA.
authors.forename: Mohamad A
authors.initials: MA
authors.lastname: Cherry
authors.forename: Himanshu
authors.initials: H
authors.lastname: Bhardwaj
authors.forename: Sarah
authors.initials: S
authors.lastname: Hopps
authors.forename: Samer
authors.initials: S
authors.lastname: Srour
authors.forename: Shubham
authors.initials: S
authors.lastname: Pant
mesh_terms: D058186:Acute Kidney Injury / Q000139:chemically induced* / Q000628:therapy; D000368:Aged; D018906:Antineoplastic Agents, Alkylating / Q000009:adverse effects* / Q000627:therapeutic use; D001927:Brain Diseases / Q000139:chemically induced* / Q000628:therapy; D006801:Humans; D007069:Ifosfamide / Q000009:adverse effects* / Q000627:therapeutic use; D016403:Lymphoma, Large B-Cell, Diffuse / Q000188:drug therapy; D008297:Male; D006435:Renal Dialysis / Q000379:methods
chemical_list: D018906:Antineoplastic Agents, Alkylating; D007069:Ifosfamide
keywords: Ifosfamide neurotoxicity and nephrotoxicity; chemotherapy side effects; hemodialysis