title: Lycojaponicumins D and E: two new alkaloids from Lycopodium japonicum.
abstract: Two new alkaloids, lycojaponicumins D (1) and E (2), were isolated from the club moss Lycopodium japonicum. Their structures were elucidated by spectroscopic methods, calculated ECD, CD experiments and X-ray diffraction analysis. Lycojaponicumin D (1) possesses an unprecedented 5/7/6/6 tetracyclic skeleton formed by an unusual C3-C13 linkage, which is first reported in Lycopodium alkaloids. The plausible biogenetic pathway of 1 is proposed.
authors.affiliation: State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China.
authors.forename: Xiao-Jing
authors.initials: XJ
authors.lastname: Wang
authors.forename: Yun-Bao
authors.initials: YB
authors.lastname: Liu
authors.forename: Li
authors.initials: L
authors.lastname: Li
authors.forename: Shi-Shan
authors.initials: SS
authors.lastname: Yu
authors.forename: Hai-Ning
authors.initials: HN
authors.lastname: Lv
authors.forename: Shuang-Gang
authors.initials: SG
authors.lastname: Ma
authors.forename: Xiu-Qi
authors.initials: XQ
authors.lastname: Bao
authors.forename: Dan
authors.initials: D
authors.lastname: Zhang
authors.forename: Jing
authors.initials: J
authors.lastname: Qu
authors.forename: Yong
authors.initials: Y
authors.lastname: Li
mesh_terms: D000470:Alkaloids / Q000737:chemistry / Q000302:isolation & purification* / Q000378:metabolism; D018360:Crystallography, X-Ray; D032502:Lycopodium / Q000737:chemistry*; D008968:Molecular Conformation; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular
chemical_list: D000470:Alkaloids; C579656:lycojaponicumin D; C579657:lycojaponicumin E