title: [Resistant enterobacteria: explosion of extended-spectrum beta-lactamases].
abstract: During the past recent years, Enterobacteriaceae have supplanted Gram-positives in terms of frequent resistant bacteria seen in the outpatent setting. This change involves common opportunistic pathogens such as E. coli and K. pneumoniae. It is mainly due to the appearance and dissemination of extended-spectrum beta-lactamases (ESBL), that hydrolyse penicillins and cephalosporins. Bacteria producing these enzymes are often also resistant to quinolones and trimethoprime-sulfamethoxazole. This article, illustrated by a clinical case, presents the current epidemiology of ESBL-producing Enterobacteriaceae and the possible prevention measures and treatment options to fight the growing number of infections that they are causing.
authors.affiliation: Service des maladies infectieuses, Institut central, Hôpital du Valais, Sion. delphine.berthod@hopitalvs.ch
authors.forename: D
authors.initials: D
authors.lastname: Berthod
authors.forename: R
authors.initials: R
authors.lastname: Pouget
authors.forename: D
authors.initials: D
authors.lastname: San Millán
authors.forename: N
authors.initials: N
authors.lastname: Troillet
mesh_terms: D024881:Drug Resistance, Bacterial; D004755:Enterobacteriaceae / Q000187:drug effects* / Q000201:enzymology*; D004926:Escherichia coli / Q000187:drug effects / Q000201:enzymology; D004927:Escherichia coli Infections / Q000188:drug therapy*; D006801:Humans; D008297:Male; D008875:Middle Aged; D001618:beta-Lactamases
chemical_list: D001618:beta-Lactamases