title: Signal-BNF: a Bayesian network fusing approach to predict signal peptides.
abstract: A signal peptide is a short peptide chain that directs the transport of a protein and has become the crucial vehicle in finding new drugs or reprogramming cells for gene therapy. As the avalanche of new protein sequences generated in the postgenomic era, the challenge of identifying new signal sequences has become even more urgent and critical in biomedical engineering. In this paper, we propose a novel predictor called Signal-BNF to predict the N-terminal signal peptide as well as its cleavage site based on Bayesian reasoning network. Signal-BNF is formed by fusing the results of different Bayesian classifiers which used different feature datasets as its input through weighted voting system. Experiment results show that Signal-BNF is superior to the popular online predictors such as Signal-3L and PrediSi. Signal-BNF is featured by high prediction accuracy that may serve as a useful tool for further investigating many unclear details regarding the molecular mechanism of the zip code protein-sorting system in cells.
authors.affiliation: Key Laboratory of Network Security and Cryptology, Fujian Normal University, Fuzhou 350007, China.
authors.forename: Zhi
authors.initials: Z
authors.lastname: Zheng
authors.forename: Youying
authors.initials: Y
authors.lastname: Chen
authors.forename: Liping
authors.initials: L
authors.lastname: Chen
authors.forename: Gongde
authors.initials: G
authors.lastname: Guo
authors.forename: Yongxian
authors.initials: Y
authors.lastname: Fan
authors.forename: Xiangzeng
authors.initials: X
authors.lastname: Kong
mesh_terms: D000465:Algorithms; D000595:Amino Acid Sequence; D000596:Amino Acids; D000818:Animals; D001499:Bayes Theorem; D030562:Databases, Protein; D006801:Humans; D057927:Hydrophobic and Hydrophilic Interactions; D021382:Protein Sorting Signals; D011506:Proteins / Q000737:chemistry; D020539:Sequence Analysis, Protein / Q000379:methods*
chemical_list: D000596:Amino Acids; D021382:Protein Sorting Signals; D011506:Proteins