title: Can inhA mutation predict ethionamide resistance?
abstract: METHODS
  A tertiary care centre in Mumbai, India.
  
  
  OBJECTIVE
  To estimate the extent of association between inhA mutant isoniazid (INH) resistant strains and ethionamide (ETH) resistance.
  
  
  METHODS
  A total of 140 clinical isolates processed for INH and ETH phenotypic drug  susceptibility testing, and molecularly processed with the line-probe assay (LPA) Genotype® MTBDRplus, were considered.
  
  
  RESULTS
  Among the 112 phenotypically determined INH-resistant strains, 69 (61.6%) strains were ETH-resistant. An inhA promoter mutation was identified  in 24 (21.4%) INH-resistant isolates, 21 (87.5%) of which were ETH-resistant (P < 0.0001).
  
  
  CONCLUSIONS
  An inhA promoter mutation could be considered as a marker for the determination of ETH resistance in India, where the use of LPA is being expanded.
authors.affiliation: P D Hinduja National Hospital and Medical Research Centre, Mumbai, India.
authors.forename: V
authors.initials: V
authors.lastname: Vadwai
authors.forename: K
authors.initials: K
authors.lastname: Ajbani
authors.forename: M
authors.initials: M
authors.lastname: Jose
authors.forename: V P
authors.initials: VP
authors.lastname: Vineeth
authors.forename: C
authors.initials: C
authors.lastname: Nikam
authors.forename: M
authors.initials: M
authors.lastname: Deshmukh
authors.forename: A
authors.initials: A
authors.lastname: Shetty
authors.forename: R
authors.initials: R
authors.lastname: Soman
authors.forename: C
authors.initials: C
authors.lastname: Rodrigues
mesh_terms: D000995:Antitubercular Agents / Q000494:pharmacology*; D001426:Bacterial Proteins / Q000235:genetics*; D005000:Ethionamide / Q000494:pharmacology*; D006801:Humans; D008826:Microbial Sensitivity Tests; D009154:Mutation; D009169:Mycobacterium tuberculosis / Q000187:drug effects* / Q000235:genetics*; D010088:Oxidoreductases / Q000235:genetics*
chemical_list: D000995:Antitubercular Agents; D001426:Bacterial Proteins; D010088:Oxidoreductases; C085257:InhA protein, Mycobacterium; D005000:Ethionamide