title: A new hepatotoxic triterpenoid ketone from Curculigo orchioides.
abstract: To investigate hepatotoxic constituents, a new cycloartane-type triterpenoid ketone together with four known components was isolated from rhizomes of Curculigo orchioides. The structures of five compounds were elucidated on the basis of spectroscopic methods, including 1D and 2D NMR, and single-crystal X-ray diffraction analysis. Their hepatotoxicity effects in human hepatic cell line HL-7702 were tested for the first time.
authors.affiliation: Chengdu Institute of Biology, Chinese Academy of Sciences, Chengdu 610041, China. jw2272001@yahoo.com.cn
authors.forename: Wei
authors.initials: W
authors.lastname: Jiao
authors.forename: Xiaozhen
authors.initials: X
authors.lastname: Chen
authors.forename: Haibo
authors.initials: H
authors.lastname: Wang
authors.forename: Runhua
authors.initials: R
authors.lastname: Lu
authors.forename: Huawu
authors.initials: H
authors.lastname: Shao
mesh_terms: D000818:Animals; D002460:Cell Line; D031408:Curculigo / Q000737:chemistry* / Q000633:toxicity*; D022781:Hepatocytes / Q000187:drug effects*; D006801:Humans; D007659:Ketones / Q000737:chemistry*; D015394:Molecular Structure; D027343:Rhizome / Q000737:chemistry; D014315:Triterpenes / Q000737:chemistry* / Q000633:toxicity*
chemical_list: D007659:Ketones; D014315:Triterpenes