title: Statin treatment of children with familial hypercholesterolemia--trying to balance incomplete evidence of long-term safety and clinical accountability: are we approaching a consensus?
abstract: In the heterozygous form of familial hypercholesterolemia (FH), blood concentrations of low-density lipoprotein cholesterol (LDL-C) are elevated two to three times above the normal range since birth, and cause strongly elevated risk of premature coronary artery disease (CAD). There is no evidence that statin therapy is unsafe in FH children, and it has not been associated with clinically significant changes in measures of growth or maturation, liver enzymes, serum creatine kinase, or incidence of myopathy. However, the opinions among clinicians, and between countries, about the age at which statin therapy should be initiated in FH children vary. This review attempts to critically examine the available data, so that clinically the most appropriate age of initiating statin treatment in FH children as a preventive measure for future CAD could be established.
authors.affiliation: Health Center Mehiläinen, Vantaa, Finland.
authors.forename: Alpo
authors.initials: A
authors.lastname: Vuorio
authors.forename: Kieran F
authors.initials: KF
authors.lastname: Docherty
authors.forename: Steve E
authors.initials: SE
authors.lastname: Humphries
authors.forename: Jaana
authors.initials: J
authors.lastname: Kuoppala
authors.forename: Petri T
authors.initials: PT
authors.lastname: Kovanen
mesh_terms: D000293:Adolescent; D050197:Atherosclerosis; D001921:Brain / Q000187:drug effects / Q000254:growth & development; D059168:Carotid Intima-Media Thickness; D002648:Child; D002784:Cholesterol / Q000502:physiology; D008078:Cholesterol, LDL / Q000097:blood; D003324:Coronary Artery Disease / Q000517:prevention & control; D005260:Female; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000627:therapeutic use*; D006938:Hyperlipoproteinemia Type II / Q000188:drug therapy*; D008297:Male; D012307:Risk Factors; D012941:Social Responsibility
chemical_list: D008078:Cholesterol, LDL; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D002784:Cholesterol