title: Polysaccharide enriched immunomodulatory fractions from Tinospora cordifolia (Willd) miers ax hook. f. & Thoms.
abstract: Tinospora cordifolia is used in Ayurveda as "Rasayanas" to improve the immune system and the body resistance against infections. Polysaccharides are the main constituents which are considered to be responsible for immune enhancement. In this study, immunomodulatory activity of three polysaccharide enriched fractions was evaluated using the polymorphonuclear leukocyte function test. Sugar composition was determined by GC-MS analysis of the derivatised fractions. The active polysaccharide fractions mainly constitute glucose, fructose and arabinose as monomer units.
authors.affiliation: Natural Plant Products Division, CSIR-Institute of Himalayan Bioresource Technology (IHBT), Palampur, 176 061, India.
authors.forename: Upendra
authors.initials: U
authors.lastname: Sharma
authors.forename: Manju
authors.initials: M
authors.lastname: Bala
authors.forename: Rikki
authors.initials: R
authors.lastname: Saini
authors.forename: Praveen Kumar
authors.initials: PK
authors.lastname: Verma
authors.forename: Neeraj
authors.initials: N
authors.lastname: Kumar
authors.forename: Bikram
authors.initials: B
authors.lastname: Singh
authors.forename: Renuka Kulkarni
authors.initials: RK
authors.lastname: Munshi
authors.forename: Supriya
authors.initials: S
authors.lastname: Bhalerao
mesh_terms: D001089:Arabinose / Q000737:chemistry; D002176:Candida albicans / Q000187:drug effects / Q000472:pathogenicity; D002470:Cell Survival / Q000187:drug effects; D005632:Fructose / Q000737:chemistry; D005947:Glucose / Q000737:chemistry; D006801:Humans; D007107:Immune System; D009504:Neutrophils / Q000187:drug effects*; D010587:Phagocytosis / Q000187:drug effects; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology; D011134:Polysaccharides / Q000737:chemistry / Q000494:pharmacology; D031610:Tinospora / Q000737:chemistry*
chemical_list: D010936:Plant Extracts; D011134:Polysaccharides; D005632:Fructose; D001089:Arabinose; D005947:Glucose