title: The role of interleukin-9 in lymphoma.
abstract: Although much progress has been made in the treatment of lymphomas, the unclear molecular etiology limits its further development. Interleukin-9 (IL-9) was initially described as a growth factor secreted by activated helper T cells type 2 (Th2). Various observations have demonstrated its diverse actions in immune and inflammatory responses. In recent years, a resurgence of interest in IL-9 has been spurred by the expanded identification of its cellular sources and biological targets. Also, the determination of its growth-proliferative and anti-apoptotic activities on multiple transformed cells implies a potential role of this cytokine in tumorigenesis. In this article we review the biologic properties and signal transduction pathways of IL-9, and furthermore discuss its possible role in lymphomagenesis as well as its impact on non-malignant infiltrating cells which are characteristic of the tumor microenvironment.
authors.affiliation: Department of Hematology, Provincial Hospital Affiliated to Shandong University, Jinan, China.
authors.forename: Xiao
authors.initials: X
authors.lastname: Lv
authors.forename: Xin
authors.initials: X
authors.lastname: Wang
mesh_terms: D002471:Cell Transformation, Neoplastic / Q000235:genetics / Q000378:metabolism; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D016906:Interleukin-9 / Q000235:genetics* / Q000378:metabolism*; D008223:Lymphoma / Q000235:genetics* / Q000276:immunology / Q000378:metabolism*; D015398:Signal Transduction; D059016:Tumor Microenvironment / Q000235:genetics / Q000276:immunology
chemical_list: D016906:Interleukin-9