title: Phase-resolved acoustic radiation force optical coherence elastography.
abstract: Many diseases involve changes in the biomechanical properties of tissue, and there is a close correlation between tissue elasticity and pathology. We report on the development of a phase-resolved acoustic radiation force optical coherence elastography method (ARF-OCE) to evaluate the elastic properties of tissue. This method utilizes chirped acoustic radiation force to produce excitation along the sample's axial direction, and it uses phase-resolved optical coherence tomography (OCT) to measure the vibration of the sample. Under 500-Hz square wave modulated ARF signal excitation, phase change maps of tissue mimicking phantoms are generated by the ARF-OCE method, and the resulting Young's modulus ratio is correlated with a standard compression test. The results verify that this technique could efficiently measure sample elastic properties accurately and quantitatively. Furthermore, a three-dimensional ARF-OCE image of the human atherosclerotic coronary artery is obtained. The result indicates that our dynamic phase-resolved ARF-OCE method can delineate tissues with different mechanical properties.
authors.affiliation: University of California, Irvine, Beckman Laser Institute, Irvine, California 92612, USA.
authors.forename: Wenjuan
authors.initials: W
authors.lastname: Qi
authors.forename: Ruimin
authors.initials: R
authors.lastname: Chen
authors.forename: Lidek
authors.initials: L
authors.lastname: Chou
authors.forename: Gangjun
authors.initials: G
authors.lastname: Liu
authors.forename: Jun
authors.initials: J
authors.lastname: Zhang
authors.forename: Qifa
authors.initials: Q
authors.lastname: Zhou
authors.forename: Zhongping
authors.initials: Z
authors.lastname: Chen
mesh_terms: D001696:Biomechanical Phenomena; D003324:Coronary Artery Disease / Q000473:pathology / Q000503:physiopathology; D003331:Coronary Vessels / Q000473:pathology / Q000503:physiopathology; D055119:Elastic Modulus; D054459:Elasticity Imaging Techniques / Q000295:instrumentation / Q000379:methods*; D006801:Humans; D055620:Optical Phenomena; D019047:Phantoms, Imaging; D061088:Photoacoustic Techniques / Q000295:instrumentation / Q000379:methods*; D041623:Tomography, Optical Coherence / Q000295:instrumentation / Q000379:methods*