title: Asymmetric total synthesis of an iboga-type indole alkaloid, voacangalactone, newly isolated from Voacanga africana.
abstract: A new hexacyclic iboga-type indole alkaloid, voacangalactone (1), was isolated from  Voacanga africana , and its structure including the absolute configuration was established by asymmetric total synthesis involving such key steps as the asymmetric Diels-Alder reaction using an aminodiene and the construction of an isoquinuclidine ring and an indole skeleton.
authors.affiliation: Graduate School of Pharmaceutical Sciences, Chiba University, 1-8-1 Inohana, Chiba 260-8675, Japan.
authors.forename: Masaya
authors.initials: M
authors.lastname: Harada
authors.forename: Ken Nunettsu
authors.initials: KN
authors.lastname: Asaba
authors.forename: Masumi
authors.initials: M
authors.lastname: Iwai
authors.forename: Noriyuki
authors.initials: N
authors.lastname: Kogure
authors.forename: Mariko
authors.initials: M
authors.lastname: Kitajima
authors.forename: Hiromitsu
authors.initials: H
authors.lastname: Takayama
mesh_terms: D026121:Indole Alkaloids / Q000737:chemistry / Q000302:isolation & purification*; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D013237:Stereoisomerism; D030014:Tabernaemontana / Q000737:chemistry; D036902:Voacanga / Q000737:chemistry*
chemical_list: D026121:Indole Alkaloids