title: [Value of neutrophil CD64 in the diagnosis of community acquired pneumonia in children].
abstract: OBJECTIVE
  To study the clinical value of the expression of neutrophil surface CD64 in the diagnosis of community acquired pneumonia in children.
  
  
  METHODS
  Ninety-eight children with community acquired pneumonia were recruited into the study and were classified into three groups according to pathogene: bacterial pneumonia (n=48), viral pneumonia (n=29) and Mycoplasmal pneumonia (n=21). Twenty healthy children were enrolled as controls. The bacterial infection group was subdivided into mild infection (n=36) and severe infection groups (n=12). The levels of peripheral blood neutrophil CD64 were measured using flow cytometry. Dynamic changes of C-reactive protein were also detected for each patient.
  
  
  RESULTS
  The CD64 index and CRP levels in the bacterial pneumonia group were significantly higher than in the other three groups (P<0.05). The CD64 index in the severe bacterial infection group was significantly higher than in the mild group (P<0.05). After antibiotic treatment, expression of CD64 in the severe bacterial infection group decreased significantly (P<0.05). The CD64 index was positively correlated with CRP value (r=0.545, P<0.01). ROC curve analysis showed that the threshold of CD64 and CRP was 2.8 and 8 mg/L respectively. Specificity of CD64 index (90%) was much higher than CRP (74%).
  
  
  CONCLUSIONS
  The determination of peripheral blood neutrophil CD64 contributes to the early diagnosis of pulmonary bacterial infection and the evaluation of anti-infection effect.
authors.affiliation: Department of Pediatrics, Affiliated Hospital of Nantong University, Nantong, Jiangsu 226001, China.
authors.forename: Qun
authors.initials: Q
authors.lastname: Cai
authors.forename: Mei-Yu
authors.initials: MY
authors.lastname: Xu
mesh_terms: D002097:C-Reactive Protein / Q000032:analysis; D002648:Child; D002675:Child, Preschool; D017714:Community-Acquired Infections / Q000097:blood / Q000175:diagnosis*; D005260:Female; D006801:Humans; D008297:Male; D009504:Neutrophils / Q000737:chemistry*; D018410:Pneumonia, Bacterial / Q000097:blood / Q000175:diagnosis*; D012372:ROC Curve; D017452:Receptors, IgG / Q000097:blood*
chemical_list: C489017:FCGR1A protein, human; D017452:Receptors, IgG; D002097:C-Reactive Protein