title: Survival after pancreatectomy for pancreatic adenocarcinoma is not impacted by performance status.
abstract: BACKGROUND
  Patients with the best performance status have the best prognosis after resection for pancreatic adenocarcinoma. This study was undertaken to determine the impact of performance status on survival after pancreatectomy for adenocarcinoma.
  
  
  METHODS
  Patients with a Karnofsky Performance Score (KPS) status (KPS) ≥60 after pancreatectomy for adenocarcinoma were evaluated, and the impact of the KPS at 6 weeks after pancreatectomy on survival was determined using survival curve analysis.
  
  
  RESULTS
  Recurrence was experienced by 84% of patients and negatively impacted patient survival. The median overall survival was 12 months, and the 2-year overall survival was 35%. The KPS after pancreatectomy did not impact survival when using survival curve analysis (P = .5740).
  
  
  CONCLUSIONS
  Performance status for patients with a KPS ≥60 after pancreatectomy does not impact survival. Patients with pancreatic adenocarcinoma without adjuvant therapy have poor overall survival, and KPS after pancreatectomy for adenocarcinoma should not be used to withhold therapy for these patients.
authors.affiliation: Department of Surgery, University of South Florida College of Medicine, Tampa, FL 33606, USA. jmullina@health.usf.edu
authors.forename: John E
authors.initials: JE
authors.lastname: Mullinax
authors.forename: Jonathan M
authors.initials: JM
authors.lastname: Hernandez
authors.forename: Paul
authors.initials: P
authors.lastname: Toomey
authors.forename: Desiree
authors.initials: D
authors.lastname: Villadolid
authors.forename: Carl
authors.initials: C
authors.lastname: Bowers
authors.forename: Jennifer
authors.initials: J
authors.lastname: Cooper
authors.forename: Alexander S
authors.initials: AS
authors.lastname: Rosemurgy
mesh_terms: D000230:Adenocarcinoma / Q000401:mortality / Q000473:pathology / Q000601:surgery* / Q000628:therapy; D059186:Chemoradiotherapy, Adjuvant; D003661:Decision Support Techniques; D006801:Humans; D053208:Kaplan-Meier Estimate; D017567:Karnofsky Performance Status; D009362:Neoplasm Metastasis; D009364:Neoplasm Recurrence, Local / Q000401:mortality; D010180:Pancreatectomy; D010190:Pancreatic Neoplasms / Q000401:mortality / Q000473:pathology / Q000601:surgery* / Q000628:therapy; D016577:Pancreaticoduodenectomy; D011446:Prospective Studies; D015996:Survival Rate; D016896:Treatment Outcome