title: Protective effects of subchronic caffeine administration on cisplatin induced urogenital toxicity in male mice.
abstract: In Cisplatin treated group, the degeneration intensity of the kidneys the diameter of seminiferous tubules as well as the apoptotic index in testes and kidney were increased. In Caffeine+Cisplatin treated groups, the total body weight, the weight of testes and kidneys and also the histopathological data did not show significant differences. The motility of sperm in cisplatin group reduced but in Caffeine+Cisplatin groups this parameter was increased. These data suggest that caffeine recovers toxicity induced by cisplatin in both kidneys and testes of mice.
authors.affiliation: Fertility and Infertility Research Center, Kermanshah University of Medical Sciences, P.O. Box 1568, Kermanshah, Iran.
authors.forename: M
authors.initials: M
authors.lastname: Khazaei
authors.forename: P D
authors.initials: PD
authors.lastname: Bayat
authors.forename: A
authors.initials: A
authors.lastname: Ghanbari
authors.forename: S
authors.initials: S
authors.lastname: Khazaei
authors.forename: M
authors.initials: M
authors.lastname: Feizian
authors.forename: A
authors.initials: A
authors.lastname: Khodaei
authors.forename: H A S
authors.initials: HA
authors.lastname: Alian
mesh_terms: D000818:Animals; D001835:Body Weight / Q000187:drug effects; D002110:Caffeine / Q000008:administration & dosage*; D002945:Cisplatin / Q000633:toxicity*; D007668:Kidney / Q000187:drug effects; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D020011:Protective Agents / Q000008:administration & dosage*; D013081:Sperm Motility / Q000187:drug effects; D013737:Testis / Q000187:drug effects
chemical_list: D020011:Protective Agents; D002110:Caffeine; D002945:Cisplatin