title: Effectiveness of the Lanzhou lamb rotavirus vaccine against gastroenteritis among children.
abstract: The Lanzhou lamb rotavirus (LLR) vaccine has been in use in China since 2000. This study evaluated this vaccine's effectiveness using a case-control design in Guangzhou. In the study area, there were 3130 laboratory-confirmed rotavirus gastroenteritis cases in children between 2 and 35 months old from 2009 to 2011. A total of 3607 controls were also enrolled in this study. Of the subjects, 970 (14.4%) had received 1 dose of the LLR vaccine. Because of the low vaccination rate, we only obtained an effectiveness of 44.3% (95% CI, 28.4-56.7%) for children 9-11 months old, 52.8% (40.8-62.3%) for children 12-17 months old, and 51.8% (11.6-73.8%) for children 18-35 months old for one dose. This post-marketing study found that one dose of the LLR vaccine confers partial protection when given to children between 9 and 35 months old. Therefore, earlier immunization and the administration of the full immunization regimen should be encouraged.
authors.affiliation: Guangzhou Center for Disease Control and Prevention, Guangzhou, China. fuchuanxi@gmail.com
authors.forename: Chuanxi
authors.initials: C
authors.lastname: Fu
authors.forename: Qing
authors.initials: Q
authors.lastname: He
authors.forename: Jianxiong
authors.initials: J
authors.lastname: Xu
authors.forename: Huaping
authors.initials: H
authors.lastname: Xie
authors.forename: Peng
authors.initials: P
authors.lastname: Ding
authors.forename: Wensui
authors.initials: W
authors.lastname: Hu
authors.forename: Zhiqiang
authors.initials: Z
authors.lastname: Dong
authors.forename: Xiangyi
authors.initials: X
authors.lastname: Liu
authors.forename: Ming
authors.initials: M
authors.lastname: Wang
mesh_terms: D016022:Case-Control Studies; D002675:Child, Preschool; D002681:China; D005260:Female; D005759:Gastroenteritis / Q000517:prevention & control* / Q000821:virology*; D006801:Humans; D007223:Infant; D008297:Male; D012400:Rotavirus Infections / Q000276:immunology* / Q000517:prevention & control*; D022243:Rotavirus Vaccines / Q000627:therapeutic use*; D014611:Vaccination
chemical_list: D022243:Rotavirus Vaccines