title: [Ultramicrostructural study of pathological changes of capillary vessels in pulp tissues of diabetes mellitus patients].
abstract: OBJECTIVE
  To investigate the relationship between diabetes mellitus and pulposis and the pathogenesis of diabetes mellitus pulposis, via comparing the pulp tissue conditions and ultramicrostructures of capillary vessels in pulp tissues of diabetes mellitus patients and normal control.
  
  
  METHODS
  Pulp tissues were obtained from clinically extracted human third molars with impaction (control group, 30 cases) and intact third molars with impaction (non-insulin dependent diabetes patients) whilst without pulposis symptom (diabetic group, 30 cases). The pathological changes of two groups' pulp tissues were evaluated under light microscope and electron microscopy. The thickness of pulp capillary basement membrane and their anionic sites were quantitatively analyzed by electron microscopy and special staining. Statistical analysis was performed using SAS6.12 software package.
  
  
  RESULTS
  The tricked blood capillary wall was observed in diabetic pulp under light microscope. The thickened blood capillary wall and constrictive lumen were observed in diabetic pulp under electron microscope, accompanied with vascular endothelial cell swelling and structural destruction and thickened basement membrane (P<0.01). The decrease of anionic sites of capillary basement membrane was observed in diabetic pulp under specially stained electron microscope (P<0.01).
  
  
  CONCLUSIONS
  Inflammatory reaction existed in the pulp of intact teeth of DM patients without symptoms. The changes observed in diabetic vessels may occur in the dental pulp. Diabetes mellitus is closely related to pulposis.
authors.affiliation: Department of Stomatology, Shanghai Jiao Tong University, Shanghai, China.
authors.forename: Xiao-li
authors.initials: XL
authors.lastname: Wang
authors.forename: Chang-yi
authors.initials: CY
authors.lastname: Yang
authors.forename: Zun
authors.initials: Z
authors.lastname: Zhang
authors.forename: Qing
authors.initials: Q
authors.lastname: Sun
authors.forename: Liu-qing
authors.initials: LQ
authors.lastname: Yang
mesh_terms: D001485:Basement Membrane; D002196:Capillaries; D016022:Case-Control Studies; D003782:Dental Pulp; D003920:Diabetes Mellitus; D042783:Endothelial Cells; D006801:Humans; D007249:Inflammation; D008854:Microscopy, Electron