title: The basic science of dermal fillers: past and present Part I: background and mechanisms of action.
abstract: Dermal fillers have provided a safe and effective means for aesthetic soft tissue augmentation, and have experienced a dramatic increase in popularity during the past 10 years. Much focus has been placed upon filler technique and patient outcomes. However, there is a relative lack of literature reviewing the basic science of dermal fillers, which is vital to a physician's understanding of how each product behaves in vivo. Part I of this article reviews the basic science and evolution of both historical and contemporary dermal fillers; Part II examines their adverse effects. We endeavor to provide the physician with a practical approach to choosing products that maximize both aesthetic outcome and safety.
authors.affiliation: Department of Dermatology, SUNY Downstate Medical Center, Brooklyn, NY 11203, USA. doctorgilbert@gmail.com
authors.forename: Erin
authors.initials: E
authors.lastname: Gilbert
authors.forename: Andrea
authors.initials: A
authors.lastname: Hui
authors.forename: Heidi A
authors.initials: HA
authors.lastname: Waldorf
mesh_terms: D000818:Animals; D001672:Biocompatible Materials / Q000008:administration & dosage*; D003357:Cosmetic Techniques; D006801:Humans; D012060:Rejuvenation; D015595:Skin Aging; D016896:Treatment Outcome
chemical_list: D001672:Biocompatible Materials