title: Laser in situ keratomileusis using optimized aspheric profiles and cyclotorsion control to treat compound myopic astigmatism with high cylinder.
abstract: OBJECTIVE
  To evaluate the visual outcomes after laser in situ keratomileusis (LASIK) surgery to correct primary compound myopic astigmatism with high cylinder performed using a fast-repetition-rate excimer laser platform with optimized aspheric profiles and cyclotorsion control.
  
  
  METHODS
  Vissum Corporation and Division of Ophthalmology, Universidad Miguel Hernández, Alicante, Spain.
  
  
  METHODS
  Retrospective consecutive observational nonrandomized noncomparative case series.
  
  
  METHODS
  Eyes with primary compound myopic astigmatism and a cylinder power over 3.00 diopters (D) had uneventful LASIK with femtosecond flap creation and fast-repetition-rate excimer laser ablation with aspheric profiles and cyclotorsion control. Visual, refractive, and aberrometric outcomes were evaluated at the 6-month follow-up. The astigmatic correction was evaluated using the Alpins method and Assort software.
  
  
  RESULTS
  The study enrolled 37 eyes (29 patients; age range 19 to 55 years). The significant reduction in refractive sphere and cylinder 3 months and 6 months postoperatively (P<.01) was associated with improved uncorrected distance visual acuity (P<.01). Eighty-seven percent of eyes had a spherical equivalent within ±0.50 D; 7.5% of eyes were retreated. There was no significant induction of higher-order aberrations (HOAs). The targeted and surgically induced astigmatism magnitudes were 3.23 D and 2.96 D, respectively, and the correction index was 0.91. The safety and efficacy indices were 1.05 and 0.95, respectively.
  
  
  CONCLUSIONS
  Laser in situ keratomileusis for primary compound myopic astigmatism with high cylinder (>3.00 D) performed using a fast-repetition-rate excimer laser with optimized aspheric profiles and cyclotorsion control was safe, effective, and predictable and did not cause significant induction of HOAs.
authors.affiliation: From the Vissum Corporation (Alió, Plaza-Puche, Martinez, Torky, Brenner) and the Division of Ophthalmology (Alió), Universidad Miguel Hernández, Alicante, Spain; Mansoura University (Torky), Mansoura, Egypt. Electronic address: jlalio@vissum.com.
authors.forename: Jorge L
authors.initials: JL
authors.lastname: Alió
authors.affiliation: From the Vissum Corporation (Alió, Plaza-Puche, Martinez, Torky, Brenner) and the Division of Ophthalmology (Alió), Universidad Miguel Hernández, Alicante, Spain; Mansoura University (Torky), Mansoura, Egypt.
authors.forename: Ana B
authors.initials: AB
authors.lastname: Plaza-Puche
authors.affiliation: From the Vissum Corporation (Alió, Plaza-Puche, Martinez, Torky, Brenner) and the Division of Ophthalmology (Alió), Universidad Miguel Hernández, Alicante, Spain; Mansoura University (Torky), Mansoura, Egypt.
authors.forename: Lorena M
authors.initials: LM
authors.lastname: Martinez
authors.affiliation: From the Vissum Corporation (Alió, Plaza-Puche, Martinez, Torky, Brenner) and the Division of Ophthalmology (Alió), Universidad Miguel Hernández, Alicante, Spain; Mansoura University (Torky), Mansoura, Egypt.
authors.forename: Magda
authors.initials: M
authors.lastname: Torky
authors.affiliation: From the Vissum Corporation (Alió, Plaza-Puche, Martinez, Torky, Brenner) and the Division of Ophthalmology (Alió), Universidad Miguel Hernández, Alicante, Spain; Mansoura University (Torky), Mansoura, Egypt.
authors.forename: Luis F
authors.initials: LF
authors.lastname: Brenner
mesh_terms: D000328:Adult; D001251:Astigmatism / Q000503:physiopathology / Q000601:surgery*; D003316:Corneal Diseases / Q000517:prevention & control; D057108:Corneal Wavefront Aberration / Q000503:physiopathology; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D020731:Keratomileusis, Laser In Situ / Q000379:methods*; D054018:Lasers, Excimer / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D009216:Myopia / Q000503:physiopathology / Q000601:surgery*; D012029:Refraction, Ocular / Q000502:physiology; D012086:Reoperation; D012189:Retrospective Studies; D013524:Surgical Flaps; D014102:Torsion Abnormality / Q000517:prevention & control*; D016896:Treatment Outcome; D014792:Visual Acuity / Q000502:physiology; D055815:Young Adult