title: Fisetin: a dietary antioxidant for health promotion.
abstract: CONCLUSIONS
  Diet-derived antioxidants are now being increasingly investigated for their health-promoting effects, including their role in the chemoprevention of cancer. In general, botanical antioxidants have received much attention, as they can be consumed for longer periods of time without any adverse effects. Flavonoids are a broadly distributed class of plant pigments that are regularly consumed in the human diet due to their abundance. One such flavonoid, fisetin (3,3',4',7-tetrahydroxyflavone), is found in various fruits and vegetables, such as strawberry, apple, persimmon, grape, onion, and cucumber.
  
  
  BACKGROUND
  Several studies have demonstrated the effects of fisetin against numerous diseases. It is reported to have neurotrophic, anticarcinogenic, anti-inflammatory, and other health beneficial effects.
  
  
  RESULTS
  Although fisetin has been reported as an anticarcinogenic agent, further in-depth in vitro and in vivo studies are required to delineate the mechanistic basis of its observed effects. In this review article, we describe the multiple effects of fisetin with special emphasis on its anticancer activity as investigated in cell culture and animal models.
  
  
  CONCLUSIONS
  Additional research focused toward the identification of molecular targets could lead to the development of fisetin as a chemopreventive/chemotherapeutic agent against cancer and other diseases.
authors.affiliation: Department of Dermatology, University of Wisconsin, Madison, WI 53706, USA.
authors.forename: Naghma
authors.initials: N
authors.lastname: Khan
authors.forename: Deeba N
authors.initials: DN
authors.lastname: Syed
authors.forename: Nihal
authors.initials: N
authors.lastname: Ahmad
authors.forename: Hasan
authors.initials: H
authors.lastname: Mukhtar
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology; D000975:Antioxidants / Q000494:pharmacology*; D004032:Diet; D005419:Flavonoids / Q000494:pharmacology*; D044948:Flavonols; D006293:Health Promotion / Q000379:methods*; D006801:Humans; D009369:Neoplasms / Q000188:drug therapy / Q000517:prevention & control
chemical_list: D000970:Antineoplastic Agents; D000975:Antioxidants; D005419:Flavonoids; D044948:Flavonols; C017875:fisetin