title: Emergence and spread of plasmid-borne tet(B)::ISCR2 in minocycline-resistant Acinetobacter baumannii isolates.
abstract: Resistance to minocycline has emerged in multidrug-resistant Acinetobacter baumannii isolates from Buenos Aires hospitals. Few reports about the description and dispersion of tet genes in this species have been published. We observed the presence of tet(B) in all minocycline-resistant isolates. This gene was found to be associated with the ISCR2 mobile element, which may, in part, explain its dispersion.
authors.affiliation: Instituto de Microbiología y Parasitología Médica (IMPaM, UBA-CONICET), Facultad de Medicina, Universidad de Buenos Aires, Argentina.
authors.forename: Elisabet
authors.initials: E
authors.lastname: Vilacoba
authors.forename: Marisa
authors.initials: M
authors.lastname: Almuzara
authors.forename: Lucia
authors.initials: L
authors.lastname: Gulone
authors.forename: German Matías
authors.initials: GM
authors.lastname: Traglia
authors.forename: Silvia A
authors.initials: SA
authors.lastname: Figueroa
authors.forename: Gabriela
authors.initials: G
authors.lastname: Sly
authors.forename: Analia
authors.initials: A
authors.lastname: Fernández
authors.forename: Daniela
authors.initials: D
authors.lastname: Centrón
authors.forename: María Soledad
authors.initials: MS
authors.lastname: Ramírez
mesh_terms: D000151:Acinetobacter Infections / Q000188:drug therapy / Q000453:epidemiology / Q000382:microbiology*; D040981:Acinetobacter baumannii / Q000235:genetics* / Q000302:isolation & purification; D000900:Anti-Bacterial Agents / Q000494:pharmacology / Q000627:therapeutic use*; D001118:Argentina / Q000453:epidemiology; D001483:Base Sequence; D006801:Humans; D008826:Microbial Sensitivity Tests; D008911:Minocycline / Q000494:pharmacology / Q000627:therapeutic use*; D008969:Molecular Sequence Data; D010957:Plasmids; D018626:Retroelements; D017422:Sequence Analysis, DNA; D013753:Tetracycline Resistance / Q000235:genetics*
chemical_list: D000900:Anti-Bacterial Agents; D018626:Retroelements; D008911:Minocycline