title: Protective immunity from a germinal center sanctuary.
abstract: A new study provides mechanistic insights into how live attenuated simian immunodeficiency virus (SIV) vaccines (LAVs) can protect monkeys from infection with pathogenic SIV. The authors show that replicating LAVs stimulate a protective immune response from a safe haven in the germinal centers of lymph nodes (pages 1673-1681).
authors.affiliation: Geovax, Smyrna, GA, USA. hrobinson@geovax.com
authors.forename: Harriet L
authors.initials: HL
authors.lastname: Robinson
authors.forename: Rama Rao
authors.initials: RR
authors.lastname: Amara
mesh_terms: D000818:Animals; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology*; D006801:Humans; D008297:Male; D018449:SAIDS Vaccines; D016097:Simian Acquired Immunodeficiency Syndrome; D015302:Simian Immunodeficiency Virus; D014613:Vaccines, Attenuated
chemical_list: D018449:SAIDS Vaccines; D014613:Vaccines, Attenuated