title: MATLAB-implemented estimation procedure for model-based assessment of hepatic insulin degradation from standard intravenous glucose tolerance test data.
abstract: Present study provides a novel MATLAB-based parameter estimation procedure for individual assessment of hepatic insulin degradation (HID) process from standard frequently-sampled intravenous glucose tolerance test (FSIGTT) data. Direct access to the source code, offered by MATLAB, enabled us to design an optimization procedure based on the alternating use of Gauss-Newton's and Levenberg-Marquardt's algorithms, which assures the full convergence of the process and the containment of computational time. Reliability was tested by direct comparison with the application, in eighteen non-diabetic subjects, of well-known kinetic analysis software package SAAM II, and by application on different data. Agreement between MATLAB and SAAM II was warranted by intraclass correlation coefficients ≥0.73; no significant differences between corresponding mean parameter estimates and prediction of HID rate; and consistent residual analysis. Moreover, MATLAB optimization procedure resulted in a significant 51% reduction of CV% for the worst-estimated parameter by SAAM II and in maintaining all model-parameter CV% <20%. In conclusion, our MATLAB-based procedure was suggested as a suitable tool for the individual assessment of HID process.
authors.affiliation: Department of Information Engineering, Università Politecnica delle Marche, 60131 Ancona, Italy. f.dinardo@univpm.it
authors.forename: Francesco
authors.initials: F
authors.lastname: Di Nardo
authors.forename: Michele
authors.initials: M
authors.lastname: Mengoni
authors.forename: Micaela
authors.initials: M
authors.lastname: Morettini
mesh_terms: D000465:Algorithms; D001786:Blood Glucose / Q000378:metabolism; D002096:C-Peptide / Q000378:metabolism; D005951:Glucose Tolerance Test / Q000379:methods*; D006801:Humans; D007328:Insulin / Q000378:metabolism / Q000493:pharmacokinetics*; D050417:Insulin-Secreting Cells / Q000378:metabolism; D016014:Linear Models; D008099:Liver / Q000378:metabolism; D008875:Middle Aged; D011381:Programming Languages; D015203:Reproducibility of Results; D012815:Signal Processing, Computer-Assisted; D012984:Software; D013997:Time Factors
chemical_list: D001786:Blood Glucose; D002096:C-Peptide; D007328:Insulin