title: Insights from the docking analysis of biologically active compounds from plant Litsea Genus as potential COX-2 inhibitors.
abstract: Litsea spp of Laural family are traditionally used as herbal medicine for treating inflammation including gastroenterologia, oedema and rheumatic arthritis. Therefore, it is of interest to investigate and understand the molecular principles for such actions. Here, we have illustrated the binding of thirteen Litsea derived biologically active compounds against the inflammation associated target COX (cyclo-oxygenase) -2 enzymes. We compared the binding information of these compounds with a selected number of already known COX-2 inhibitors. The comparison reflected that some of these compounds such as linderol, catechin, 6'-hydroxy-2',3',4' - trimethoxy-chalcone and litseaone have better or equivalent binding features compared to already known inhibitory compounds namely celecoxib, acetylsalicylic acid, rofecoxib. Therefore, all these small compounds reported from plant Litsea spp were found to possess potential medicinal values with anti-inflammatory properties.
authors.affiliation: Bioinformatics Infrastructure Facility, Biotechnology Division, CSIR-North East Institute of Science and Technology, Jorhat, 785 006 Assam.
authors.forename: Dhrubajyoti
authors.initials: D
authors.lastname: Gogoi
authors.forename: Rajib Lochan
authors.initials: RL
authors.lastname: Bezbaruah
authors.forename: Manabjyoti
authors.initials: M
authors.lastname: Bordoloi
authors.forename: Rajeev
authors.initials: R
authors.lastname: Sarmah
authors.forename: Tarun Chandra
authors.initials: TC
authors.lastname: Bora
keywords: COX-2 inhibitor; Docking; Inflammation; Litsea plant