title: Subchronic oral toxicity studies of the traditional herbal formula Bangpungtongseong-san in Crl: CD (SD) rats.
abstract: OBJECTIVE
  The clinical usefulness of medications generally depends on their efficacy and safety. Bangpungtongsung-san (BPTS), a traditional herbal medicine, is widely used to treat patients in Korea, Japan (Bofu-tsusho-san), and China (Fang feng tong sheng-san) as an antiobesity prescription. The objective of the present study was to evaluate the subchronic toxicity of a BPTS water extract in Crl:CD SD rats.
  
  
  METHODS
  BPTS was administered to rats orally once daily at doses of 0, 500, 1000, and 2000 mg/kg/day for 13 weeks. Toxicological parameters included clinical signs, body weight, water and food consumption, ophthalmological signs, relative organ weight, hematological and serum biochemical parameters, and histopathological assessment.
  
  
  RESULTS
  No treatment-related adverse effects were observed regarding the physiological parameters examined during the study or in the evaluation of blood, urea, and tissue samples taken from the animals at the end of the study.
  
  
  CONCLUSIONS
  In conclusion, the no-observed-adverse-effect-level for BPTS was determined to be a dietary dose of over 2000 mg/kg for both sexes under the present experimental conditions.
authors.affiliation: Basic Herbal Research Group, Korea Institute of Oriental Medicine, Exporo 483, Yuseong-gu, Daejeon 305-811, Republic of Korea.
authors.forename: Mee-Young
authors.initials: MY
authors.lastname: Lee
authors.forename: In-Sik
authors.initials: IS
authors.lastname: Shin
authors.forename: Chang-Seob
authors.initials: CS
authors.lastname: Seo
authors.forename: Jung-Hoon
authors.initials: JH
authors.lastname: Kim
authors.forename: So-Ri
authors.initials: SR
authors.lastname: Han
authors.forename: Hyeun-Kyoo
authors.initials: HK
authors.lastname: Shin
mesh_terms: D000284:Administration, Oral; D000818:Animals; D019440:Anti-Obesity Agents / Q000633:toxicity*; D004365:Drugs, Chinese Herbal / Q000633:toxicity*; D005260:Female; D008297:Male; D019055:No-Observed-Adverse-Effect Level; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D019440:Anti-Obesity Agents; D004365:Drugs, Chinese Herbal; C098310:bofu-tsusho-san