title: Retroviral intasomes: progress and questions.
abstract: In this issue of Structure, Gupta and colleagues apply a combination of biophysical approaches to study the solution properties of prototype foamy virus (PFV) integrase alone and in complex with viral DNA ends (intasome). The results complement and extend previous structural studies of PFV intasomes by X-ray crystallography and highlight the synergy of solution and crystallographic approaches to the study of nucleoprotein complexes.
authors.affiliation: Laboratory of Molecular Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
authors.forename: Min
authors.initials: M
authors.lastname: Li
authors.forename: Robert
authors.initials: R
authors.lastname: Craigie
mesh_terms: D004279:DNA, Viral / Q000378:metabolism*; D019426:Integrases / Q000737:chemistry*; D016092:Spumavirus / Q000201:enzymology*
chemical_list: D004279:DNA, Viral; D019426:Integrases