title: Desferrioxamine-cadmium as a 'Trojan horse' for the delivery of Cd to bacteria and fungi.
abstract: Molecules naturally designed for the acquisition of essential metals can be used as a shuttle to deliver toxic metal ions to target organisms. In this study, we describe for the first time the synthesis of a derivative of cadmium and desferrioxamine B, a bacterial siderophore. The new compound was characterized by elemental analysis, vibrational (infrared and Raman) spectroscopy, mass coupled thermal analyses and X-ray diffraction methods. Studies on the in vitro toxicity toward a fungus and two bacterial strains indicated that the coordination compound is more active against microrganisms than cadmium chloride on a Cd-concentration basis, indicating that desferrioxamine can work as a "Trojan horse" in the delivery of a toxic metal.
authors.affiliation: Universidade de São Paulo, Instituto de Química, Laboratório de Química Bioinorgânica Ambiental e Metalofármacos, Av Lineu Prestes 748, São Paulo, Brazil.
authors.forename: Ana Luiza Costa
authors.initials: AL
authors.lastname: Mattos
authors.forename: Vera Regina Leopoldo
authors.initials: VR
authors.lastname: Constantino
authors.forename: Ricardo Alexandre Alves
authors.initials: RA
authors.lastname: de Couto
authors.forename: Delia Manuela Luna
authors.initials: DM
authors.lastname: Pinto
authors.forename: Telma Mary
authors.initials: TM
authors.lastname: Kaneko
authors.forename: Breno Pannia
authors.initials: BP
authors.lastname: Espósito
mesh_terms: D001419:Bacteria / Q000187:drug effects*; D002104:Cadmium / Q000633:toxicity*; D002152:Calorimetry, Differential Scanning; D003676:Deferoxamine / Q000737:chemistry*; D005658:Fungi / Q000187:drug effects*; D013058:Mass Spectrometry; D008826:Microbial Sensitivity Tests; D011208:Powders; D017550:Spectroscopy, Fourier Transform Infrared; D013059:Spectrum Analysis, Raman; D013818:Thermogravimetry; D014961:X-Ray Diffraction
chemical_list: D011208:Powders; D002104:Cadmium; D003676:Deferoxamine