title: [Study of αB-crystallin and its possible role of anti-apoptosis in oral verrucous carcinoma].
abstract: OBJECTIVE
  To investigate the expression of αB-crystallin and its possible role of anti-apoptosis in oral verrucous carcinoma.
  
  
  METHODS
  The expression of αB-crystallin and activated caspase-3 was detected in oral verrucous carcinoma, oral squamous carcinoma and normal mucosa by immunohistochemistry, and their relationship was investigated. SPSS 16.0 software package was used for statistical analysis. Nonparametric test and spearman correlation test were performed.
  
  
  RESULTS
  The expression of αB-crystallin in oral verrucous carcinoma and oral squamous carcinoma was significantly higher than that in normal mucosa(P<0.05). And in oral verrucous carcinoma, the increase of expression of αB-crystallin coincided with the decrease of expression of activated caspase-3(P<0.05).
  
  
  CONCLUSIONS
  αB-crystallin may play a role of anti-apoptosis by inhibiting the activation of caspase-3 in oral verrucous carcinoma.
authors.affiliation: Department of Oral and Maxillofacial Surgery, Xiangya School of Stomatology, Central South University, Changsha 410008, Hunan Province, China. qqhhzzcool@163.com
authors.forename: Hong-zhi
authors.initials: HZ
authors.lastname: Quan
authors.forename: Zhan-gui
authors.initials: ZG
authors.lastname: Tang
authors.forename: Li-li
authors.initials: LL
authors.lastname: Zhao
authors.forename: Zhi-gang
authors.initials: ZG
authors.lastname: Yao
authors.forename: Bai-sheng
authors.initials: BS
authors.lastname: Wang
authors.forename: Shang
authors.initials: S
authors.lastname: Xie
mesh_terms: D017209:Apoptosis; D002294:Carcinoma, Squamous Cell; D018289:Carcinoma, Verrucous; D003459:Crystallins; D006801:Humans; D009062:Mouth Neoplasms; D038203:alpha-Crystallin B Chain
chemical_list: D003459:Crystallins; D038203:alpha-Crystallin B Chain