title: Spiculisporic acids B–D, three new γ-butenolide derivatives from a sea urchin-derived fungus Aspergillus sp. HDf2.
abstract: Three new &#947;-butenolide derivatives 1&#8211;3, named spiculisporic acids B&#8211;D, were isolated from the culture of Aspergillus sp. HDf2, a marine-derived fungus that resides in the sea urchin, Anthocidaris crassispina. The structures of 1&#8211;3 were elucidated on the basis of spectroscopic methods, including MS and 2D NMR techniques. Their in vitro cytotoxic activities against two cell lines (SGC-7901, human gastric adenocarcinoma and SPC-A-1, human lung adenocarcinoma) and inhibitory activities against Staphylococcus aureus ATCC 51650 were investigated.
authors.affiliation: Hainan Provincial Fisheries Research Institute, Haikou 570203, Hainan, China.
authors.forename: Rong
authors.initials: R
authors.lastname: Wang
authors.forename: Tian-Mi
authors.initials: TM
authors.lastname: Liu
authors.forename: Ming-Hui
authors.initials: MH
authors.lastname: Shen
authors.forename: Ming-Qiu
authors.initials: MQ
authors.lastname: Yang
authors.forename: Quan-Ying
authors.initials: QY
authors.lastname: Feng
authors.forename: Xian-Ming
authors.initials: XM
authors.lastname: Tang
authors.forename: Xiang-Min
authors.initials: XM
authors.lastname: Li
mesh_terms: D015107:4-Butyrolactone / Q000031:analogs & derivatives* / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D000818:Animals; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D001230:Aspergillus / Q000737:chemistry*; D002460:Cell Line; D052978:Disk Diffusion Antimicrobial Tests; D006801:Humans; D020128:Inhibitory Concentration 50; D009682:Magnetic Resonance Spectroscopy; D008968:Molecular Conformation; D012617:Sea Urchins / Q000382:microbiology*; D021241:Spectrometry, Mass, Electrospray Ionization; D013211:Staphylococcus aureus / Q000187:drug effects
chemical_list: D000900:Anti-Bacterial Agents; C579369:spiculisporic acid B; C579371:spiculisporic acid C; C579370:spiculisporic acid D; D015107:4-Butyrolactone