title: Diabetes severely affects attentional performance after coronary artery bypass grafting.
abstract: BACKGROUND
  Diabetes is a risk factor for (micro) vascular damage of the brain, too. Therefore cognitive performance after coronary artery bypass grafting may be hypothesized worse in diabetics. To avoid observational errors a reliable tool for testing attentional performance was used. We evaluated whether diabetes mellitus disposes to distinct cognitive dysfunction after coronary artery bypass grafting (CABG).
  
  
  METHODS
  Three aspects in attentional performance were prospectively tested with three different tests (alertness: composed of un-cued and cued reaction, divided attention, and selective attention) by a computerized tool one day before and seven days after CABG in a highly selected cohort of 30 males, 10 of whom had diabetes. Statistical comparisons were done with analysis of variance for repeated measurements and Fisher's LSD.
  
  
  RESULTS
  Prior to CABG there was no statistically meaningful difference between diabetics and non-diabetics. Postoperatively, diabetic patients performed significantly worse than non-diabetics in tests for un-cued (p=0.01) and cued alertness (p=0.03). Test performance in divided attention was worse after CABG but independent of diabetes status. Selective attention was neither affected by diabetes status nor by CABG itself.
  
  
  CONCLUSIONS
  Diabetes may have an impact on cognitive performance after CABG. More severe deficits in alertness may point to underlying microvascular disease.
authors.affiliation: Department of Cardiothoracic Surgery, University Hospital Würzburg, Oberdürrbacherstraße 6, Würzburg, 97080, Germany. krannich_j@klinik.uni-wuerzburg.de
authors.forename: Jens-Holger
authors.initials: JH
authors.lastname: Krannich
authors.forename: Therese
authors.initials: T
authors.lastname: Tobias
authors.forename: Jens
authors.initials: J
authors.lastname: Broscheit
authors.forename: Rainer
authors.initials: R
authors.lastname: Leyh
authors.forename: Wolfgang
authors.initials: W
authors.lastname: Müllges
mesh_terms: D000368:Aged; D000704:Analysis of Variance; D001288:Attention; D003072:Cognition Disorders / Q000378:metabolism* / Q000523:psychology; D001026:Coronary Artery Bypass / Q000009:adverse effects / Q000379:methods* / Q000706:statistics & numerical data*; D003920:Diabetes Mellitus / Q000503:physiopathology* / Q000523:psychology; D006801:Humans; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D012307:Risk Factors