title: Polo boxes come out of the crypt: a new view of PLK function and evolution.
abstract: Polo-like kinases (PLKs) are marked by C-terminal polo box modules with critical protein interaction and subcellular targeting roles. Slevin et al. in this issue of Structure reveal the architecture of a hidden set of polo boxes from the divergent PLK4, a critical player in centrosome duplication, shedding new light on the evolution of PLKs and their functionally related kinase ZYG-1.
authors.affiliation: Instituto Gulbenkian de Ciência, Rua da Quinta Grande 6, 2780-156 Oeiras, Portugal. sjana@igc.gulbenkian.pt
authors.forename: Swadhin Chandra
authors.initials: SC
authors.lastname: Jana
authors.forename: J Fernando
authors.initials: JF
authors.lastname: Bazan
authors.forename: Mónica
authors.initials: M
authors.lastname: Bettencourt-Dias
authors.forename: Mónica
authors.initials: M
authors.lastname: Bettencourt Dias
mesh_terms: D002502:Centrioles; D006801:Humans; D017346:Protein Serine-Threonine Kinases / Q000737:chemistry*
chemical_list: C490219:PLK4 protein, human; D017346:Protein Serine-Threonine Kinases