title: A structure-based model of RIG-I activation.
abstract: A series of high-resolution crystal structures of RIG-I and RIG-I:dsRNA cocrystals has recently been reported. Comparison of these structures provides considerable insight into how this innate immune pattern recognition receptor is activated upon detecting and binding a certain class of viral RNAs.
authors.affiliation: Department of Microbiology and Molecular Medicine, University of Geneva School of Medicine, CMU, 1211 Geneva, Switzerland. daniel.kolakofsky@unige.ch
authors.forename: Daniel
authors.initials: D
authors.lastname: Kolakofsky
authors.forename: Eva
authors.initials: E
authors.lastname: Kowalinski
authors.forename: Stephen
authors.initials: S
authors.lastname: Cusack
mesh_terms: D018360:Crystallography, X-Ray; D000071457:DEAD Box Protein 58; D053487:DEAD-box RNA Helicases / Q000737:chemistry* / Q000276:immunology / Q000378:metabolism*; D004789:Enzyme Activation; D006801:Humans; D007113:Immunity, Innate; D008024:Ligands; D046911:Macromolecular Substances; D008954:Models, Biological; D008958:Models, Molecular; D011487:Protein Conformation; D055503:Protein Multimerization; D012330:RNA, Double-Stranded / Q000737:chemistry / Q000378:metabolism; D012367:RNA, Viral / Q000737:chemistry / Q000378:metabolism; D011971:Receptors, Immunologic; D015398:Signal Transduction
chemical_list: D008024:Ligands; D046911:Macromolecular Substances; D012330:RNA, Double-Stranded; D012367:RNA, Viral; D011971:Receptors, Immunologic; C452820:RIGI protein, human; D000071457:DEAD Box Protein 58; D053487:DEAD-box RNA Helicases