title: Contributory factors in herb-induced fatal aconite poisoning.
abstract: Detailed investigations of all reported cases of herb-induced aconite poisoning are necessary to identify the major contributory causes so that preventive measures can be formulated. In the present review of 12 fatal cases that were published in the medical journals during 1992 and 2011, the available clinical data and forensic toxicological analyses indicated that poor post-harvest processing of aconite roots, use of greater than the recommended doses and inadequate boiling of processed aconite roots during decoction preparation were important contributory factors in herb-induced aconite poisoning. Under such circumstances, the actual amount of Aconitum alkaloids ingested was much larger than intended. Good manufacturing practice to ensure adequate processing of aconite roots, use of the recommended doses, clear instructions for the patients and their compliance during decoction preparation are important preventive measures.
authors.affiliation: Division of Clinical Pharmacology, Department of Medicine and Therapeutics, Faculty of Medicine, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong, China. tykchan@cuhk.edu.hk
authors.forename: Thomas Y K
authors.initials: TY
authors.lastname: Chan
mesh_terms: D031841:Aconitum / Q000506:poisoning*; D003296:Cooking; D004305:Dose-Response Relationship, Drug; D004365:Drugs, Chinese Herbal; D053593:Forensic Toxicology; D006801:Humans; D018517:Plant Roots / Q000506:poisoning
chemical_list: D004365:Drugs, Chinese Herbal