title: Reversible sensing of the anticoagulant heparin with protamine permselective membranes.
abstract: A permselective membrane electrode allows the rapid and operationally reversible detection of the polycationic polypeptide protamine in physiological samples. Anticoagulant levels of heparin can be measured in undiluted whole blood by adding a known excess of its antidote protamine to discrete blood samples.
authors.affiliation: Department of Inorganic, Analytical and Applied Chemistry, University of Geneva, Quai E. Ansermet 30, 1211 Geneva, Switzerland.
authors.forename: Gastón A
authors.initials: GA
authors.lastname: Crespo
authors.forename: Majid Ghahraman
authors.initials: MG
authors.lastname: Afshar
authors.forename: Eric
authors.initials: E
authors.lastname: Bakker
mesh_terms: D000925:Anticoagulants / Q000097:blood*; D004566:Electrodes; D006493:Heparin / Q000097:blood*; D006801:Humans; D008567:Membranes, Artificial; D011199:Potentiometry; D011479:Protamines / Q000097:blood*
chemical_list: D000925:Anticoagulants; D008567:Membranes, Artificial; D011479:Protamines; D006493:Heparin