title: [Intrauterine myelomeningocele repair: experience of the fetal medicine and therapy program of the Virgen de Rocío University Hospital].
abstract: The most frequent form of spina bifida is myelomeningocele. There is no optimal postnatal treatment for this defect. In addition to the motor or sensory deficits, which depend on the location of the lesion, the defect is usually associated with Chiari ii malformation in affected children. Myelomeningocele has high mortality and, in up to 80% to 90% of patients, can be accompanied by hydrocephalus, which causes severe neurocognitive impairment and requires the patient to be shunted for survival. Intrauterine repair of fetal malformations employing open access through hysterotomy has become a therapeutic option due to improved anesthetic and surgical techniques and instrumentation, which have allowed this type of intervention to become relatively frequent. Anesthetic treatment should focus on both the mother and fetus and the hemodynamic factors regulating placental flow, uterine dynamics, blood loss and fetal well-being must remain well-controlled. Within our Program for Fetal Medicine and Therapy, 21 open fetal interventions have been performed: 17 EXIT procedures and 4 procedures for the intrauterine correction of fetal myelomeningocele. We describe our experience of the intrauterine repair of fetal myelomeningocele through open fetal surgery.
authors.affiliation: Hospital Universitario Virgen del Rocío, Sevilla, España.
authors.forename: M L
authors.initials: ML
authors.lastname: Marenco
authors.forename: J
authors.initials: J
authors.lastname: Márquez
authors.forename: A
authors.initials: A
authors.lastname: Ontanilla
authors.forename: L
authors.initials: L
authors.lastname: García-Díaz
authors.forename: M
authors.initials: M
authors.lastname: Rivero
authors.forename: A
authors.initials: A
authors.lastname: Losada
authors.forename: R
authors.initials: R
authors.lastname: Torrejón
authors.forename: J A
authors.initials: JA
authors.lastname: Sainz
authors.forename: G
authors.initials: G
authors.lastname: Antiñolo
mesh_terms: D000328:Adult; D005260:Female; D005315:Fetal Diseases / Q000601:surgery*; D005333:Fetus / Q000601:surgery*; D006785:Hospitals, University; D006801:Humans; D008591:Meningomyelocele / Q000601:surgery*; D013030:Spain; D013514:Surgical Procedures, Operative / Q000379:methods