title: Oral pemphigus vegetans: a case report.
abstract: Pemphigus is a rare vesiculobullous autoimmune disease that exhibits blistering of the skin and oral cavity. It is caused by autoantibodies directed against antigens on the surface of keratinocytes. All forms of pemphigus are associated with the presence of circulating and skin-fixed autoantibodies. Pemphigus vegetans is a rare clinical variant of pemphigus vulgaris and comprises up to 5 percent of all pemphigus cases. In the following we present the oral presentation of pemphigus vegetans. We describe a 33-year-old man who was referred to our clinic complaining about mouth sores, tooth pain, and multiple pustules. During clinical exam we were able to recognize multiple pustules, ulcerated areas on the gingiva, and whitish mucosal plaques. Clinical, histopathological, and direct immunofluorescence findings were compatible with pemphigus vegetans.
authors.affiliation: Department of Oral Pathology, School of Dentistry, University of São Paulo, São Paulo, Brazil.
authors.forename: Marcio
authors.initials: M
authors.lastname: Augusto de Oliveira
authors.forename: Fabiana
authors.initials: F
authors.lastname: Martins E Martins
authors.forename: Silvia
authors.initials: S
authors.lastname: Lourenço
authors.forename: Marina
authors.initials: M
authors.lastname: Gallottini
authors.forename: Karem L
authors.initials: KL
authors.lastname: Ortega
mesh_terms: D000328:Adult; D002908:Chronic Disease; D019085:Fluorescent Antibody Technique, Direct; D006801:Humans; D007150:Immunohistochemistry; D015212:Inflammatory Bowel Diseases / Q000150:complications; D008297:Male; D009059:Mouth Diseases / Q000150:complications / Q000175:diagnosis* / Q000378:metabolism; D019226:Oral Ulcer / Q000175:diagnosis; D010392:Pemphigus / Q000150:complications / Q000175:diagnosis* / Q000378:metabolism