title: Mean platelet volume in neonatal sepsis.
abstract: BACKGROUND
  The aim of this study was to investigate any changes in mean platelet volume (MPV) in patients with neonatal sepsis (NS).
  
  
  METHODS
  Subjects were stratified into two groups: proven sepsis (Group 1a) and clinical sepsis (Group 1b). The control group (Group 2) consisted of healthy newborns matched for gestational age and birth weight.
  
  
  RESULTS
  A total of 100 patients with NS (35 with proven sepsis and 65 with clinical sepsis) and 50 healthy controls were enrolled. A comparison of markers of sepsis obtained at baseline revealed white blood cell count (WBC), C-reactive protein (CRP), interleukin-6 (IL-6), and MPV levels to be significantly higher in newborns with sepsis compared to healthy controls (P = 0.01, <0.001, <0.001, and 0.001, respectively). Mean baseline serum levels of CRP and MPV were significantly higher in Group 1a compared to Group 1b (P = 0.003, P = 0.007, respectively), whereas the difference between group with regards to baseline serum levels of IL-6 and platelet count was statistically insignificant (P = 0.14, P = 0.28, respectively).
  
  
  CONCLUSIONS
  This is the first study to demonstrate a statistically significant difference with regard to baseline MPV values between patients with sepsis (proven or clinical) and healthy controls.
authors.affiliation: Division of Neonatology, Zekai Tahir Burak Maternity Teaching Hospital, Ankara, Turkey. dryekta@gmail.com
authors.forename: Mehmet Yekta
authors.initials: MY
authors.lastname: Oncel
authors.forename: Ramazan
authors.initials: R
authors.lastname: Ozdemir
authors.forename: Sadik
authors.initials: S
authors.lastname: Yurttutan
authors.forename: Fuat Emre
authors.initials: FE
authors.lastname: Canpolat
authors.forename: Omer
authors.initials: O
authors.lastname: Erdeve
authors.forename: Serife Suna
authors.initials: SS
authors.lastname: Oguz
authors.forename: Nurdan
authors.initials: N
authors.lastname: Uras
authors.forename: Ugur
authors.initials: U
authors.lastname: Dilmen
mesh_terms: D016470:Bacteremia / Q000097:blood*; D015415:Biomarkers / Q000097:blood; D001792:Blood Platelets / Q000166:cytology* / Q000473:pathology; D002097:C-Reactive Protein / Q000378:metabolism; D048429:Cell Size; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D007232:Infant, Newborn, Diseases / Q000097:blood*; D015850:Interleukin-6 / Q000097:blood; D008297:Male; D011446:Prospective Studies; D018709:Statistics, Nonparametric
chemical_list: D015415:Biomarkers; C508600:IL6 protein, human; D015850:Interleukin-6; D002097:C-Reactive Protein