title: Design and in vitro evaluation of transdermal patches based on ibuprofen-loaded electrospun fiber mats.
abstract: To improve the poor compatibility among different components of Drug-in-adhesive type patch, two novel plasters (Drug-in-fiber and Drug-in-adhesive/fiber) were developed based on ibuprofen (IBU)-loaded fiber mats. These fibrous mats were fabricated via electrospinning of cellulose acetate/poly(vinylpyrrolidone) composites in a binary solvent of N,N-dimethyl acetamide/acetone. Physical status studies suggested that Drug-in-fiber could inhibit IBU re-crystallization, but the active ingredients were released at a relatively slow rate due to the dual-resistance of fiber mat and adhesive matrix. To overcome this shortcoming, Drug-in-adhesive/fiber was designed by coupling medicated hydrophilic pressure sensitive adhesive and IBU-loaded fiber mat. This method endowed Drug-in-adhesive/fiber a fast IBU release rate and high permeated drug amount though simulative skins. This design separated enhancer from adhesive matrix, which guaranteed Drug-in-adhesive/fiber excellent adhesion forces. Hence, the plasters based on medicated fiber mats improved the compatibility among patch components.
authors.affiliation: School of Chemical Engineering and Technology, Tianjin University, Tianjin, 300072, China.
authors.forename: Yongli
authors.initials: Y
authors.lastname: Shi
authors.forename: Shuxin
authors.initials: S
authors.lastname: Xu
authors.forename: Anjie
authors.initials: A
authors.lastname: Dong
authors.forename: Jianhua
authors.initials: J
authors.lastname: Zhang
mesh_terms: D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage / Q000493:pharmacokinetics; D002478:Cells, Cultured; D002482:Cellulose / Q000031:analogs & derivatives* / Q000737:chemistry; D004337:Drug Carriers / Q000138:chemical synthesis* / Q000737:chemistry / Q000493:pharmacokinetics; D015195:Drug Design; D055664:Electrochemical Techniques / Q000379:methods; D007052:Ibuprofen / Q000008:administration & dosage* / Q000493:pharmacokinetics; D008422:Materials Testing; D008567:Membranes, Artificial; D008954:Models, Biological; D011108:Polymers / Q000138:chemical synthesis* / Q000737:chemistry; D011205:Povidone / Q000737:chemistry*; D012867:Skin / Q000187:drug effects / Q000378:metabolism; D013552:Swine; D057968:Transdermal Patch
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D004337:Drug Carriers; D008567:Membranes, Artificial; D011108:Polymers; C005062:acetylcellulose; D002482:Cellulose; D011205:Povidone; D007052:Ibuprofen