title: Predictive value of neutrophil to lymphocyte ratio in clinical outcomes of non-ST elevation myocardial infarction and unstable angina pectoris: a 3-year follow-up.
abstract: We sought to determine the prognostic value of neutrophil to lymphocyte ratio (NLR) in non-ST elevation myocardial infarction (NSTEMI) and unstable angina pectoris (UAP). A total of 308 (mean age 59.22 ± 11.93) patients with NSTEMI and UAP were prospectively evaluated. The study population was divided into tertiles based on admission NLR values. The patients were followed for clinical outcomes for up to 3 years after discharge. In the Kaplan-Meier survival analysis, 3-year mortality was 21.6% in patients with high NLR versus 3% in the low-NLR group (P < .001). In a receiver-operating characteristic curve analysis, an NLR value of 3.04 was identified as an effective cut point in NSTEMI and UAP of a 3-year cardiovascular mortality (area under curve [AUC] = 0.86, 95% confidence interval [CI] 0.8-0.92). An NLR value >3.04 yielded a sensitivity of 79% and specificity of 71%. Admission NLR is the strong and independent predictor of a 3-year cardiovascular mortality in patients with NSTEMI and UAP.
authors.affiliation: 1Department of Cardiology, Istanbul Mehmet Akif Ersoy Thoracic-Cardiovascular Surgery Training and Research Hospital, Istanbul, Turkey.
authors.forename: Mehmet
authors.initials: M
authors.lastname: Gul
authors.forename: Huseyin
authors.initials: H
authors.lastname: Uyarel
authors.forename: Mehmet
authors.initials: M
authors.lastname: Ergelen
authors.forename: Murat
authors.initials: M
authors.lastname: Ugur
authors.forename: Turgay
authors.initials: T
authors.lastname: Isık
authors.forename: Erkan
authors.initials: E
authors.lastname: Ayhan
authors.forename: Ceyhan
authors.initials: C
authors.lastname: Turkkan
authors.forename: Hale Unal
authors.initials: HU
authors.lastname: Aksu
authors.forename: Ozgur
authors.initials: O
authors.lastname: Akgul
authors.forename: Nevzat
authors.initials: N
authors.lastname: Uslu
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000789:Angina, Unstable / Q000097:blood*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008214:Lymphocytes / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000097:blood*; D009504:Neutrophils / Q000473:pathology*; D011446:Prospective Studies
keywords: cardiovascular mortality; neutrophil; non-ST elevation myocardial infarction; unstable angina pectoris