title: Probable association of tachyarrhythmia with nebulized albuterol in a child with previously subclinical wolff Parkinson white syndrome.
abstract: We present the case of a 2-year-old asthmatic boy with atrioventricular (AV)-reentry tachycardia following albuterol inhalation, who was later diagnosed with Wolff-Parkinson-White (WPW) syndrome. The Naranjo adverse drug reaction probability scale score for this adverse event was 7, indicating that the association between his AV-reentry tachycardia and inhalation of albuterol is probable. To our knowledge, this is the first case report that shows the potential arrhythmogenic effects of albuterol in a child with WPW syndrome. We urge clinicians to be aware of this potentially life-threatening adverse effect and to closely monitor these patients when they need beta-adrenergic drugs in case of emergency. Furthermore, this report highlights the dilemma regarding the safe treatment of pediatric patients with both asthma and WPW syndrome.
authors.affiliation: Department of Pediatrics and Department of Clinical Pharmacy, Rijnstate Hospital, Wagnerlaan, Arnhem, The Netherlands  ; Department of Pediatric Cardiology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands.
authors.forename: Michiel
authors.initials: M
authors.lastname: Kroesen
authors.forename: Machiel
authors.initials: M
authors.lastname: Maseland
authors.forename: Jaime
authors.initials: J
authors.lastname: Smal
authors.forename: Annet
authors.initials: A
authors.lastname: Reimer
authors.forename: Petra
authors.initials: P
authors.lastname: van Setten
keywords: Wolff-Parkinson-White syndrome; adverse drug effect; albuterol; arrhythmias; asthma