title: Innate-like behavior of human invariant natural killer T cells during herpes simplex virus infection.
abstract: Invariant natural killer T (iNKT) cells, CD1d restricted T cells, are involved in the immune responses against various infection agents. Here we describe their behavior during reactivation of human herpes simplex virus (HSV). iNKT cells exhibit only discrete changes, which however, reached statistically significant level due to the relatively large patient group. Higher percentage of iNKT cells express NKG2D. iNKT cells down-regulate NKG2A in a subset of patients. Finally, iNKT cells enhance their capacity to produce TNF-α. Our data suggests that iNKT cells are involved in the immune response against HSV and contribute mainly to its early, innate phase.
authors.affiliation: Third Faculty of Medicine, Charles University in Prague, Czech Republic.
authors.forename: Lucie
authors.initials: L
authors.lastname: Novakova
authors.forename: Zuzana
authors.initials: Z
authors.lastname: Nevoralova
authors.forename: Jan
authors.initials: J
authors.lastname: Novak
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D055610:Antigens, CD1d / Q000235:genetics / Q000276:immunology; D005260:Female; D015870:Gene Expression; D006561:Herpes Simplex / Q000276:immunology* / Q000473:pathology / Q000821:virology; D006801:Humans; D007113:Immunity, Innate; D008213:Lymphocyte Activation; D008297:Male; D008875:Middle Aged; D055655:NK Cell Lectin-Like Receptor Subfamily K / Q000235:genetics / Q000276:immunology; D055611:Natural Killer T-Cells / Q000276:immunology* / Q000473:pathology; D018139:Simplexvirus / Q000502:physiology*; D014409:Tumor Necrosis Factor-alpha / Q000235:genetics / Q000276:immunology; D014775:Virus Activation
chemical_list: D055610:Antigens, CD1d; C527085:KLRK1 protein, human; D055655:NK Cell Lectin-Like Receptor Subfamily K; D014409:Tumor Necrosis Factor-alpha