title: Clinical differences in patients with Alzheimer's disease according to the presence or absence of anosognosia: implications for perceived quality of life.
abstract: This study aimed to determine the factors that predict anosognosia in patients with Alzheimer's disease (AD) and to examine the effect of anosognosia on patient and caregiver perceptions of the patient's quality of life (QoL-p), using a cross-sectional design with 164 patients and their caregivers. Instruments of measurement included Anosognosia Questionnaire-Dementia, Geriatric Depression Scale, Quality of Life in AD (QoL-AD), Disability Assessment for Dementia, Neuropsychiatric Inventory, and the Global Deterioration Scale (GDS). A binary logistic regression analysis was performed to identify the factors that predict anosognosia, while a linear regression analysis was conducted to determine the factors associated with QoL-AD. The degree of anosognosia increased in line with GDS stage (F (2,161) = 41.3, p < 0.001). In the binary regression analysis, the variables that predicted anosognosia were more neuropsychiatric symptoms (OR = 1.11, 95% CI: 1.06-1.17, p < 0.001), deficits in ADL (OR = 0.88, 95% CI: 0.83-0.94, p < 0.001), less depression (OR = 0.66, 95% CI: 0.54-0.82, p < 0.001), and older age (OR = 1.08, 95% CI: 1.00-1.15, p = 0.027). With regards to QoL-p, the multiple linear regression analysis for patients (r2 = 0.486) showed that less depression (β = -0.52, p < 0.001) and greater anosognosia (β = 0.40, p < 0.001) explained 33% and 10% of the variance in QoL-AD, respectively. Greater anosognosia was associated with better perceived QoL-p, especially in advanced GDS stages. Anosognosia was associated with greater caregiver burden and a greater discrepancy between patient and caregiver ratings of QoL-p.
authors.affiliation: Faculty of Psychology, University of Barcelona, Barcelona, Spain. jllconde@ub.edu
authors.forename: Josep L
authors.initials: JL
authors.lastname: Conde-Sala
authors.forename: Ramón
authors.initials: R
authors.lastname: Reñé-Ramírez
authors.forename: Oriol
authors.initials: O
authors.lastname: Turró-Garriga
authors.forename: Jordi
authors.initials: J
authors.lastname: Gascón-Bayarri
authors.forename: Montserrat
authors.initials: M
authors.lastname: Juncadella-Puig
authors.forename: Laura
authors.initials: L
authors.lastname: Moreno-Cordón
authors.forename: Vanesa
authors.initials: V
authors.lastname: Viñas-Diez
authors.forename: Josep
authors.initials: J
authors.lastname: Garre-Olmo
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000377:Agnosia / Q000175:diagnosis / Q000453:epidemiology* / Q000523:psychology; D000544:Alzheimer Disease / Q000175:diagnosis / Q000453:epidemiology* / Q000523:psychology; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D008297:Male; D010465:Perception; D011788:Quality of Life / Q000523:psychology; D012720:Severity of Illness Index; D011795:Surveys and Questionnaires