title: Sparfloxacin in the treatment of purulent sinusitis-a multicentric study in Indian patients.
abstract: Sparfloxacin, a new quinolone antibacterial was used to treat one hundred and thirty two patients with acute purulent sinusitis, at a dosage of 400 mg on the first day followed by 200 mg once daily for a further four days. A clinically successful outcome (defined as disappearance of nasal discharge, fever, pain, tenderness over the sinuses and headache) was recorded in 122 ( 95.3%) patients. Sparfloxacin was well tolerated. Fourteen adverse experiences were reported in 7 patients ( 5.3%); they were mainly gastrointestinal and mild. No phototoxic or cardiological adverse events occurred. An unusual feature was that Staphylococcus aureus and Pseudomonas spp. were the most common bacterial species isolated from middle meatal was of patients in this study.
authors.affiliation: Dept of ENT, Lokmanya Tilak Medical College, Sion, Mumbai.
authors.forename: R V
authors.initials: RV
authors.lastname: Juvekar
authors.forename: S C
authors.initials: SC
authors.lastname: Mishra
authors.forename: S
authors.initials: S
authors.lastname: Naik
authors.forename: S B
authors.initials: SB
authors.lastname: Ogale
authors.forename: D
authors.initials: D
authors.lastname: Prasad
authors.forename: K
authors.initials: K
authors.lastname: Thirugnanam
authors.forename: R
authors.initials: R
authors.lastname: Gowrishankar
authors.forename: R K
authors.initials: RK
authors.lastname: Jalali
authors.forename: S K
authors.initials: SK
authors.lastname: Mishra
authors.forename: F
authors.initials: F
authors.lastname: Niazi
authors.forename: O P
authors.initials: OP
authors.lastname: Sood