title: Cerebral vasospasm and anterior circulation stroke secondary to an exacerbation of hereditary corproporphyria.
abstract: Acute porphyria, though rare, has well-known neurological sequelae. Vasospasm rarely complicates exacerbations of acute intermittent porphyria, but has not been previously reported in hereditary coproporphyria. We describe a porphyric crisis in a woman with previously undiagnosed hereditary coproporphyria (triggered by rifampicin), leading to vasospasm and stroke.
authors.affiliation: Department of Clinical Neurosciences, Royal Free Hampstead NHS Trust, London, UK. s.mullin@nhs.net
authors.forename: Stephen
authors.initials: S
authors.lastname: Mullin
authors.forename: Andrew
authors.initials: A
authors.lastname: Platts
authors.forename: Kashmir
authors.initials: K
authors.lastname: Randhawa
authors.forename: Paul
authors.initials: P
authors.lastname: Watts
mesh_terms: D000328:Adult; D001921:Brain / Q000000981:diagnostic imaging / Q000473:pathology; D046349:Coproporphyria, Hereditary / Q000139:chemically induced / Q000150:complications* / Q000628:therapy; D005260:Female; D006801:Humans; D018810:Magnetic Resonance Angiography; D008279:Magnetic Resonance Imaging; D011859:Radiography; D012293:Rifampin / Q000009:adverse effects; D020521:Stroke / Q000175:diagnosis / Q000209:etiology*; D020301:Vasospasm, Intracranial / Q000175:diagnosis / Q000209:etiology*
chemical_list: D012293:Rifampin