title: Use of Raman spectroscopy in the analysis of nickel allergy.
abstract: Raman spectra of the skin of subjects with nickel allergy are analyzed and compared to the spectra of healthy subjects to detect possible biochemical differences in the structure of the skin that could help diagnose metal allergies in a noninvasive manner. Results show differences between the two groups of Raman spectra. These spectral differences can be classified using principal component analysis. Based on these findings, a novel computational technique to make a fast evaluation and classification of the Raman spectra of the skin is presented and proposed as a noninvasive technique for the detection of nickel allergy.
authors.affiliation: University Complutense of Madrid, Applied Optics Complutense Group, Spain.
authors.forename: Javier
authors.initials: J
authors.lastname: Alda
authors.forename: Claudio
authors.initials: C
authors.lastname: Castillo-Martinez
authors.forename: Rodrigo
authors.initials: R
authors.lastname: Valdes-Rodriguez
authors.forename: Diana
authors.initials: D
authors.lastname: Hernández-Blanco
authors.forename: Benjamin
authors.initials: B
authors.lastname: Moncada
authors.forename: Francisco J
authors.initials: FJ
authors.lastname: González
mesh_terms: D000293:Adolescent; D000328:Adult; D016022:Case-Control Studies; D017449:Dermatitis, Allergic Contact / Q000175:diagnosis* / Q000209:etiology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009532:Nickel / Q000009:adverse effects*; D025341:Principal Component Analysis; D012867:Skin / Q000737:chemistry*; D013059:Spectrum Analysis, Raman / Q000379:methods
chemical_list: D009532:Nickel