title: Mitochondrial network size scaling in budding yeast.
abstract: Mitochondria must grow with the growing cell to ensure proper cellular physiology and inheritance upon division. We measured the physical size of mitochondrial networks in budding yeast and found that mitochondrial network size increased with increasing cell size and that this scaling relation occurred primarily in the bud. The mitochondria-to-cell size ratio continually decreased in aging mothers over successive generations. However, regardless of the mother's age or mitochondrial content, all buds attained the same average ratio. Thus, yeast populations achieve a stable scaling relation between mitochondrial content and cell size despite asymmetry in inheritance.
authors.affiliation: Department of Biochemistry and Biophysics, University of California-San Francisco (UCSF), San Francisco, CA, USA. susanner@uci.edu
authors.forename: Susanne M
authors.initials: SM
authors.lastname: Rafelski
authors.forename: Matheus P
authors.initials: MP
authors.lastname: Viana
authors.forename: Yi
authors.initials: Y
authors.lastname: Zhang
authors.forename: Yee-Hung M
authors.initials: YH
authors.lastname: Chan
authors.forename: Kurt S
authors.initials: KS
authors.lastname: Thorn
authors.forename: Phoebe
authors.initials: P
authors.lastname: Yam
authors.forename: Jennifer C
authors.initials: JC
authors.lastname: Fung
authors.forename: Hao
authors.initials: H
authors.lastname: Li
authors.forename: Luciano da F
authors.initials: Lda F
authors.lastname: Costa
authors.forename: Wallace F
authors.initials: WF
authors.lastname: Marshall
mesh_terms: D016193:G1 Phase; D018613:Microscopy, Confocal; D008928:Mitochondria / Q000378:metabolism* / Q000648:ultrastructure*; D053142:Mitochondrial Size; D012441:Saccharomyces cerevisiae / Q000166:cytology / Q000254:growth & development* / Q000648:ultrastructure*; D029701:Saccharomyces cerevisiae Proteins / Q000235:genetics / Q000378:metabolism; D020691:rab GTP-Binding Proteins / Q000235:genetics / Q000378:metabolism
chemical_list: D029701:Saccharomyces cerevisiae Proteins; C468556:Ypt11 protein, S cerevisiae; D020691:rab GTP-Binding Proteins