title: Role of fetuin-A in atherosclerosis associated with diabetic patients.
abstract: OBJECTIVE
  Fetuin-A is a circulating glycoprotein, formed in the liver. It regulates bone remodelling and calcium metabolism. Fetuin-A has adipogenic properties, so fat accumulation in the liver may be associated with higher levels of fetuin-A. Fetuin-A is an inhibitor of the phosphorylation of the insulin receptor tyrosine kinase.
  
  
  RESULTS
  High concentrations of fetuin-A in humans causes insulin resistance. Insulin sensitivity is also found to be increased in fetuin-A knockout mice. Fetuin-A has been shown to cause insulin resistivity in type-2 diabetes mellitus and worsens the pro-atherogenic milieu.
  
  
  CONCLUSIONS
  Fetuin-A should be considered as a hepatic bio-marker. Vascular diseases like atherosclerosis are major causes of disability in patients with diabetes mellitus.
authors.affiliation: Department of Pharmaceutical Technology, Meerut Institute of Engineering and Technology, Meerut Department of Pharmaceutical Technology, Divya Jyoti College of Pharmacy, Modinagar, Uttar Pradesh, India. singhmonika878@gmail.com
authors.forename: Monika
authors.initials: M
authors.lastname: Singh
authors.forename: Pramod Kumar
authors.initials: PK
authors.lastname: Sharma
authors.forename: Vipin Kumar
authors.initials: VK
authors.lastname: Garg
authors.forename: Shambhu Charan
authors.initials: SC
authors.lastname: Mondal
authors.forename: Avnesh Kumar
authors.initials: AK
authors.lastname: Singh
authors.forename: Nikhlesh
authors.initials: N
authors.lastname: Kumar
mesh_terms: D050156:Adipogenesis; D000818:Animals; D050197:Atherosclerosis / Q000209:etiology / Q000378:metabolism*; D015415:Biomarkers / Q000378:metabolism; D003924:Diabetes Mellitus, Type 2 / Q000150:complications / Q000378:metabolism*; D005234:Fatty Liver / Q000378:metabolism; D006801:Humans; D007333:Insulin Resistance; D008099:Liver / Q000378:metabolism*; D011972:Receptor, Insulin / Q000378:metabolism; D060749:alpha-2-HS-Glycoprotein / Q000378:metabolism*
chemical_list: D015415:Biomarkers; D060749:alpha-2-HS-Glycoprotein; D011972:Receptor, Insulin