title: Synthesis of novel МТ3 receptor ligands via an unusual Knoevenagel condensation.
abstract: New 5-acetamido-substituted melatonin derivatives were efficiently synthesized in excellent yields via Knoevenagel condensation. The relative binding affinity of new synthesized compounds to MT3 receptor was tested via enzymatic assays and the X-ray structures of the most potent compounds were determined in complex with MT3.
authors.affiliation: Moscow State University, Chemistry department, Leninskie Gory 1, Moscow, Russia. maria.s.volkov@gmail.com
authors.forename: Maria S
authors.initials: MS
authors.lastname: Volkova
authors.forename: Katherine C
authors.initials: KC
authors.lastname: Jensen
authors.forename: Natalia A
authors.initials: NA
authors.lastname: Lozinskaya
authors.forename: Sergey E
authors.initials: SE
authors.lastname: Sosonyuk
authors.forename: Marina V
authors.initials: MV
authors.lastname: Proskurnina
authors.forename: Andrew D
authors.initials: AD
authors.lastname: Mesecar
authors.forename: Nikolay S
authors.initials: NS
authors.lastname: Zefirov
mesh_terms: D000081:Acetamides / Q000737:chemistry*; D018360:Crystallography, X-Ray; D006801:Humans; D008024:Ligands; D008550:Melatonin / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D008958:Models, Molecular; D015394:Molecular Structure; D044094:Receptors, Melatonin / Q000037:antagonists & inhibitors*
chemical_list: D000081:Acetamides; D008024:Ligands; D044094:Receptors, Melatonin; D008550:Melatonin