title: Is renal allograft dysfunction a risk factor for severe infection in kidney transplant recipients?
abstract: The ANTICIPE study is a cross-sectional, multicenter, French study. The aim of this study was to describe clinical and biological parameters observed in a cohort of 1446 stable renal transplant recipients, according to the stage of chronic kidney disease. Severe infection was defined as an infection necessitating ≥ 7 days of hospital stay. We observed a negative correlation between declining glomerular filtration rate and occurrence of severe infection (P < .0001). In multivariate analysis, severe infection was associated with age, female gender, chronic kidney disease stage (Kidney Disease Outcomes Quality Initiative classification), and number of acute rejection episodes. Our study suggested that renal allograft function is a predictor not only of cardiac death and cardiovascular complications, but also of severe infections.
authors.affiliation: Department of Nephrology and Transplantation, Hôpital Lapeyronie, Montpellier, France. g-mourad@chu-montpellier.fr
authors.forename: G
authors.initials: G
authors.lastname: Mourad
authors.forename: B
authors.initials: B
authors.lastname: Dussol
authors.forename: E
authors.initials: E
authors.lastname: Daugas
authors.forename: D
authors.initials: D
authors.lastname: Joly
authors.forename: L
authors.initials: L
authors.lastname: Juillard
authors.forename: P
authors.initials: P
authors.lastname: Henri
authors.forename: P
authors.initials: P
authors.lastname: Stroumza
authors.forename: M
authors.initials: M
authors.lastname: Touam
mesh_terms: D000328:Adult; D000368:Aged; D003141:Communicable Diseases / Q000175:diagnosis / Q000453:epidemiology*; D003430:Cross-Sectional Studies; D005260:Female; D005602:France / Q000453:epidemiology; D005919:Glomerular Filtration Rate; D006801:Humans; D007668:Kidney / Q000503:physiopathology*; D016030:Kidney Transplantation / Q000009:adverse effects*; D007902:Length of Stay; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D016017:Odds Ratio; D015995:Prevalence; D012307:Risk Factors; D012720:Severity of Illness Index; D013997:Time Factors; D016896:Treatment Outcome