title: Triple-helical recognition of RNA using 2-aminopyridine-modified PNA at physiologically relevant conditions.
abstract: Peptide nucleic acids containing thymidine and 2-aminopyridine (M) nucleobases form stable and sequence-selective triple helices with double-stranded RNA at physiologically relevant conditions. The M-modified PNA showed unique RNA selectivity by having two orders of magnitude higher affinity for the double-stranded RNAs than for the same DNA sequences.
authors.affiliation: Department of Chemistry, Binghamton University, The State University of New York, Binghamton, NY 13902, USA.
authors.forename: Thomas
authors.initials: T
authors.lastname: Zengeya
authors.forename: Pankaj
authors.initials: P
authors.lastname: Gupta
authors.forename: Eriks
authors.initials: E
authors.lastname: Rozners
mesh_terms: D000631:Aminopyridines / Q000737:chemistry*; D020029:Base Pairing; D035683:MicroRNAs / Q000737:chemistry; D009690:Nucleic Acid Conformation; D020135:Peptide Nucleic Acids / Q000737:chemistry*; D012330:RNA, Double-Stranded / Q000737:chemistry*
chemical_list: D000631:Aminopyridines; D035683:MicroRNAs; D020135:Peptide Nucleic Acids; D012330:RNA, Double-Stranded; C032439:alpha-aminopyridine