title: Association of myeloperoxidase gene variation with carotid atherosclerosis in patients with essential hypertension.
abstract: The aim of this study was to investigate the association between myeloperoxidase (MPO) gene polymorphisms and carotid atherosclerosis (AS) in patients with essential hypertension (EH). A total of 214 patients with EH were divided into an AS and a non-atherosclerosis (non-AS) group. MPO gene polymorphisms in EH were detected using PCR. The frequency of increased intima-media thickness and the occurrence of plaque in the carotid artery in the AS group was higher compared to the non-AS group. The frequency of the GC genotype in the AS group was significantly higher compared to the non-AS group. The frequency of carotid AS is higher in patients with hypertension, which is related to the MPO gene polymorphism.
authors.affiliation: Department of Cardiology, The Third Ward of Cadre, People's Hospital of Gansu Province, Lanzhou, Gansu 730000, PR China.
authors.forename: Jinrui
authors.initials: J
authors.lastname: Fang
authors.forename: Liya
authors.initials: L
authors.lastname: Ma
authors.forename: Shuhong
authors.initials: S
authors.lastname: Zhang
authors.forename: Yan
authors.initials: Y
authors.lastname: Fang
authors.forename: Peng
authors.initials: P
authors.lastname: Su
authors.forename: Huiyuan
authors.initials: H
authors.lastname: Ma
mesh_terms: D000368:Aged; D000483:Alleles; D002339:Carotid Arteries / Q000473:pathology; D002340:Carotid Artery Diseases / Q000150:complications* / Q000235:genetics*; D016022:Case-Control Studies; D000075222:Essential Hypertension; D005260:Female; D005787:Gene Frequency; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D006973:Hypertension / Q000150:complications*; D008297:Male; D008875:Middle Aged; D009195:Peroxidase / Q000235:genetics*; D058226:Plaque, Atherosclerotic; D011110:Polymorphism, Genetic; D012307:Risk Factors
chemical_list: D009195:Peroxidase