title: Vitamin D receptor BsmI polymorphism and osteoporosis risk: a meta-analysis from 26 studies.
abstract: OBJECTIVE
  Growing evidence has shown that vitamin D deficiency can cause lower bone mineral density (BMD) and an increased risk of osteoporosis. Vitamin D receptor (VDR) BsmI polymorphism (rs1544410) can affect BMD variation and circulating osteocalcin levels. To date, a wide range of epidemiological studies have been carried out to evaluate the association between VDR BsmI polymorphism and susceptibility to osteoporosis. Conflicting results, however, were obtained. The aim of this study was to evaluate the effect of VDR BsmI polymorphism on osteoporosis risk using a meta-analysis.
  
  
  METHODS
  Twenty-six publications were identified by searching PubMed and Embase databases. The association between VDR BsmI polymorphism and osteoporosis was estimated by calculating pooled odds ratios (ORs) with corresponding 95% confidence intervals (CIs).
  
  
  RESULTS
  The bb genotype was associated with a significantly decreased risk of osteoporosis in overall comparison (bb vs. BB: OR=0.61, 95% CI, 0.40-0.92; bb vs. BB/Bb: OR=0.70, 95% CI, 0.52-0.95, respectively). Subgroup analyses showed that the bb genotype had a decreased risk of developing osteoporosis in postmenopausal women (bb vs. BB/Bb: OR=0.68, 95% CI, 0.46-0.98) and Africans (Bb/bb vs. BB: OR=0.18, 95% CI, 0.09-0.37).
  
  
  CONCLUSIONS
  The VDR BsmI polymorphism may have a protective role against the development of osteoporosis.
authors.affiliation: Department of Orthopedics, Kunming Medical University, National Clinical Key Specialty, Yanan Hospital, Kunming, People's Republic of China.
authors.forename: Fu
authors.initials: F
authors.lastname: Jia
authors.forename: Rui-Fen
authors.initials: RF
authors.lastname: Sun
authors.forename: Qun-Hui
authors.initials: QH
authors.lastname: Li
authors.forename: Da-Xing
authors.initials: DX
authors.lastname: Wang
authors.forename: Feng
authors.initials: F
authors.lastname: Zhao
authors.forename: Jun-Min
authors.initials: JM
authors.lastname: Li
authors.forename: Qi
authors.initials: Q
authors.lastname: Pu
authors.forename: Zhong-Zi
authors.initials: ZZ
authors.lastname: Zhang
authors.forename: Yan
authors.initials: Y
authors.lastname: Jin
authors.forename: Bai-Lian
authors.initials: BL
authors.lastname: Liu
authors.forename: Ying
authors.initials: Y
authors.lastname: Xiong
mesh_terms: D054458:Amplified Fragment Length Polymorphism Analysis; D015519:Bone Density / Q000235:genetics; D015252:Deoxyribonucleases, Type II Site-Specific / Q000235:genetics; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008875:Middle Aged; D010024:Osteoporosis / Q000453:epidemiology / Q000235:genetics*; D015663:Osteoporosis, Postmenopausal / Q000235:genetics*; D011110:Polymorphism, Genetic; D012150:Polymorphism, Restriction Fragment Length; D018167:Receptors, Calcitriol / Q000235:genetics*
chemical_list: D018167:Receptors, Calcitriol; C053864:endodeoxyribonuclease BsmI; D015252:Deoxyribonucleases, Type II Site-Specific