title: Interaction of Piscidin-1 with zwitterionic versus anionic membranes: a comparative molecular dynamics study.
abstract: Plasma membrane of each micro-organism has a unique set of lipid composition as a consequence of the environmental adaptation or a response to exposure to antimicrobial peptides (AMPs) as antibiotic agents. Understanding the relationship between lipid composition and action of antimicrobial peptides or considering how different lipid bilayers respond to AMPs may help us design more effective peptide drugs in the future. In this contribution, we intend to elucidate how two currently used membrane models, namely palmitoyl-oleoyl-phosphtidylglycerol (POPG) and 1-palmitoyl-oleoyl-glycero-phosphocholine (POPC), respond to antimicrobial peptide Piscidin-1 (Pis-1).The computed density profile of the peptide as it moves from the bulk solvent toward the membrane core suggests that Pis-1 penetrates into the POPG bilayer less than the POPC membrane. Furthermore, we showed that the two model membranes used in this study have different behavior in the presence of Pis-1. Hence, we suggest that membrane composition could be an important factor in determining lytic ability of peptide drugs to kill a unique bacterial species.
authors.affiliation: a Faculty of Science, Department of Cellular and Molecular Biology , Azarbaijan Shahid Madani University , Tabriz , 53714-161 , Iran .
authors.forename: Arezoo
authors.initials: A
authors.lastname: Rahmanpour
authors.forename: Mohammad Mehdi
authors.initials: MM
authors.lastname: Ghahremanpour
authors.forename: Faramarz
authors.initials: F
authors.lastname: Mehrnejad
authors.forename: Majid Erfani
authors.initials: ME
authors.lastname: Moghaddam
mesh_terms: D000818:Animals; D000838:Anions / Q000737:chemistry; D023181:Antimicrobial Cationic Peptides / Q000737:chemistry* / Q000378:metabolism; D002462:Cell Membrane / Q000737:chemistry* / Q000378:metabolism; D029941:Fish Proteins / Q000737:chemistry* / Q000378:metabolism; D008051:Lipid Bilayers / Q000737:chemistry / Q000378:metabolism; D008958:Models, Molecular; D008968:Molecular Conformation; D056004:Molecular Dynamics Simulation; D010713:Phosphatidylcholines / Q000737:chemistry* / Q000378:metabolism; D010715:Phosphatidylglycerols / Q000737:chemistry* / Q000378:metabolism; D011485:Protein Binding; D011487:Protein Conformation; D017434:Protein Structure, Tertiary
chemical_list: D000838:Anions; D023181:Antimicrobial Cationic Peptides; D029941:Fish Proteins; D008051:Lipid Bilayers; D010713:Phosphatidylcholines; D010715:Phosphatidylglycerols; C449802:moronecidin protein, Morone saxatilis; C060037:1-palmitoyl-2-oleoylglycero-3-phosphoglycerol; C028694:1-palmitoyl-2-oleoylphosphatidylcholine