title: On the trail of empty MHC class-I.
abstract: Since being proposed nearly 25 years ago that MHC-I molecules free of peptide ligand possess a conformation that is distinct from that of the mature loaded form, considerable research has been conducted in order to isolate and characterise such a species. While some progress has been made in our understanding, many questions still surround the nature and loading of empty MHC-I. However, the necessary tools to address these questions may finally be at hand.
authors.affiliation: Department of Biochemistry & Molecular Biology, Monash University, Melbourne, VIC 3800, Australia. alex.theodossis@monash.edu
authors.forename: Alex
authors.initials: A
authors.lastname: Theodossis
mesh_terms: D000818:Animals; D017951:Antigen Presentation; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology; D015395:Histocompatibility Antigens Class I / Q000737:chemistry / Q000276:immunology*; D006801:Humans; D051379:Mice; D010446:Peptide Fragments / Q000276:immunology; D011487:Protein Conformation
chemical_list: D015395:Histocompatibility Antigens Class I; D010446:Peptide Fragments