title: Poly-γ-(D)-glutamic acid capsule interferes with lytic infection of Bacillus anthracis by B. anthracis-specific bacteriophages.
abstract: The poly-γ-d-glutamic acid capsule of Bacillus anthracis is a barrier to infection by B. anthracis-specific bacteriophages. Capsule expression was found to completely inhibit lytic infection by γ phage, an observation supported by the demonstration that this phage does not elaborate a hydrolase that would facilitate penetration through the protective capsule outer layer.
authors.affiliation: University College London School of Pharmacy, London, United Kingdom.
authors.forename: David
authors.initials: D
authors.lastname: Negus
authors.forename: Jane
authors.initials: J
authors.lastname: Burton
authors.forename: Angela
authors.initials: A
authors.lastname: Sweed
authors.forename: Romuald
authors.initials: R
authors.lastname: Gryko
authors.forename: Peter W
authors.initials: PW
authors.lastname: Taylor
mesh_terms: D017103:Bacillus Phages / Q000201:enzymology / Q000235:genetics / Q000254:growth & development / Q000502:physiology*; D001408:Bacillus anthracis / Q000378:metabolism / Q000821:virology*; D016667:Bacterial Capsules / Q000378:metabolism*; D001433:Bacteriolysis; D004279:DNA, Viral / Q000737:chemistry / Q000235:genetics; D006867:Hydrolases / Q000235:genetics; D008969:Molecular Sequence Data; D011099:Polyglutamic Acid / Q000378:metabolism*; D017422:Sequence Analysis, DNA
chemical_list: D004279:DNA, Viral; D011099:Polyglutamic Acid; D006867:Hydrolases