title: Decumbenone C, a new cytotoxic decaline derivative from the marine fungus Aspergillus sulphureus KMM 4640.
abstract: A new decaline derivative, decumbenone C (1) along with four known compounds, decumbenones A (2) and B (3), diorcinol (4), and brevianamide F (5) were isolated from the marine fungus Aspergillus sulphureus KMM 4640. Decumbenone C shows potent cytotoxic activity against SK-MEL-5 human melanoma cells with IC(50) values of 0.9 μM.
authors.affiliation: Far Eastern Federal University, Vladivostok, Russian Federation.
authors.forename: Olesya I
authors.initials: OI
authors.lastname: Zhuravleva
authors.forename: Shamil Sh
authors.initials: SSh
authors.lastname: Afiyatullov
authors.forename: Olesya S
authors.initials: OS
authors.lastname: Vishchuk
authors.forename: Vladimir A
authors.initials: VA
authors.lastname: Denisenko
authors.forename: Natalya N
authors.initials: NN
authors.lastname: Slinkina
authors.forename: Olga F
authors.initials: OF
authors.lastname: Smetanina
mesh_terms: D000970:Antineoplastic Agents / Q000302:isolation & purification* / Q000494:pharmacology; D001230:Aspergillus / Q000737:chemistry* / Q000302:isolation & purification; D018929:Cell Culture Techniques; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D019015:Geologic Sediments / Q000382:microbiology; D006801:Humans; D020128:Inhibitory Concentration 50; D007659:Ketones / Q000302:isolation & purification / Q000494:pharmacology; D015394:Molecular Structure; D009281:Naphthalenes / Q000302:isolation & purification* / Q000494:pharmacology; D012717:Sesquiterpenes / Q000302:isolation & purification* / Q000494:pharmacology
chemical_list: D000970:Antineoplastic Agents; D007659:Ketones; D009281:Naphthalenes; D012717:Sesquiterpenes; C470967:decumbenone A; C470966:decumbenone B; C580584:decumbenone C