title: Efficacy of computed image modification of capsule endoscopy in patients with obscure gastrointestinal bleeding.
abstract: OBJECTIVE
  To investigate whether flexible spectral color enhancement (FICE) improves diagnostic yields of capsule endoscopy (CE) for obscure gastro-intestinal bleeding (OGIB).
  
  
  METHODS
  The study subjects consisted of 81 patients. Using FICE, there were three different sets with different wavelengths. Using randomly selected sets of FICE, images of CE were evaluated again by two individuals who were not shown the conventional CE reports and findings. The difference between FICE and conventional imaging was examined.
  
  
  RESULTS
  The overall diagnostic yields in FICE sets 1, 2, 3 and conventional imaging (48.1%) were 51.9%, 40.7%, 51.9% and 48.1%, respectively, which showed no statistical difference compared to conventional imaging. The total numbers of detected lesions per examination in FICE imaging and conventional imaging were 2.5 ± 2.1 and 1.8 ± 1.7, respectively, which showed a significant difference (P = 0.01).
  
  
  CONCLUSIONS
  The diagnostic yield for OGIB is not improved by FICE. However, FICE can detect significantly more small bowel lesions compared to conventional imaging.
authors.affiliation: Tomoaki Matsumura, Makoto Arai, Toru Sato, Tomoo Nakagawa, Daisuke Maruoka, Masaru Tsuboi, Sachio Hata, Eiji Arai, Tatsuro Katsuno, Fumio Imazeki, Osamu Yokosuka, Department of Medicine and Clinical Oncology, Graduate School of Medicine, Chiba University, Chiba 2608670, Japan.
authors.forename: Tomoaki
authors.initials: T
authors.lastname: Matsumura
authors.forename: Makoto
authors.initials: M
authors.lastname: Arai
authors.forename: Toru
authors.initials: T
authors.lastname: Sato
authors.forename: Tomoo
authors.initials: T
authors.lastname: Nakagawa
authors.forename: Daisuke
authors.initials: D
authors.lastname: Maruoka
authors.forename: Masaru
authors.initials: M
authors.lastname: Tsuboi
authors.forename: Sachio
authors.initials: S
authors.lastname: Hata
authors.forename: Eiji
authors.initials: E
authors.lastname: Arai
authors.forename: Tatsuro
authors.initials: T
authors.lastname: Katsuno
authors.forename: Fumio
authors.initials: F
authors.lastname: Imazeki
authors.forename: Osamu
authors.initials: O
authors.lastname: Yokosuka
keywords: Capsule endoscopy; Computed virtual chromoendoscopy; Diagnostic yield; Flexible spectral color enhancement; Obscure gastro-intestinal bleeding