title: [Pseudotumors of the central nervous system].
abstract: The histopathological differentiation of the pseudoneoplastic lesions from the tumors of the central nervous system (CNS) is not easy in a proportion of cases and the risk of diagnostic misinterpretation in biopsies of the CNS remains relatively high. Here we discuss selected CNS lesions, which can be easily mistaken for a tumor, particularly in the absence of relevant clinical and neuroradiological data - gliosis, tumefactive demyelination, radionecrosis and focal cortical dysplasia. With the exception of the recently available IDH1 immunohistochemistry, there is a lack of simple and reliable histochemical or molecular markers which could facilitate this differential diagnosis. To avoid a diagnostic error, pathologists have to rely on careful microscopic analysis along with its correlation with clinical data and neuroradiological findings.
authors.affiliation: Ústav patologie a molekulární medicíny 2, LF UK a FN Motol, Praha. josef.zamecnik@lfmotol.cuni.cz
authors.forename: J
authors.initials: J
authors.lastname: Zámečník
authors.forename: L
authors.initials: L
authors.lastname: Mrázková
mesh_terms: D002493:Central Nervous System Diseases / Q000175:diagnosis / Q000473:pathology*; D016543:Central Nervous System Neoplasms / Q000175:diagnosis / Q000473:pathology*; D003711:Demyelinating Diseases / Q000175:diagnosis / Q000473:pathology; D003937:Diagnosis, Differential; D005911:Gliosis / Q000175:diagnosis / Q000473:pathology; D006801:Humans; D011832:Radiation Injuries / Q000175:diagnosis / Q000473:pathology