title: Synthesis and physicochemical characterization of pyrrolidinium based surfactants.
abstract: Three new pyrrolidinium based surfactants were synthesized and characterized as pure aggregate components and in mixtures with 1,2-dimyristoyl-sn-glycero-3-phosphocholine to understand how the molecular structure of the cationic amphiphile and its mole percentage might affect the physicochemical properties of the resulting aggregates. The thermotropic behavior of the mixed liposomes was investigated by differential scanning calorimetry on multilamellar vesicles, whereas their size and surface potential were investigated on large unilamellar vesicles by dynamic laser light scattering and fluorescence experiments, respectively. The presence of either methoxy or hydroxy groups in the positions 3 and 4 of the pyrrolidinium ring as well as the presence of a second alkyl chain on pyrrolidinium nitrogen, controls the aggregates features.
authors.affiliation: Dipartimento di Chimica Università degli Studi di Roma "Sapienza", P.le A. Moro 5, 00185 Roma, Italy.
authors.forename: Alessandra
authors.initials: A
authors.lastname: Bartoloni
authors.affiliation: CNR, Istituto di Metodologie Chimiche and Dipartimento di Chimica Università degli Studi di Roma "Sapienza", P.le A. Moro 5, 00185 Roma, Italy.
authors.forename: Cecilia
authors.initials: C
authors.lastname: Bombelli
authors.affiliation: Dipartimento per l'Innovazione nei sistemi Biologici, Agroalimentari e Forestali, Università della Tuscia, Largo dell'Università, 01100 Viterbo, Italy.
authors.forename: Stefano
authors.initials: S
authors.lastname: Borocci
authors.affiliation: Dipartimento di Ingegneria Chimica, Materiali, Ambiente Università degli Studi di Roma "Sapienza", P.le A. Moro 5, 00185 Roma, Italy.
authors.forename: Maria Grazia
authors.initials: MG
authors.lastname: Bonicelli
authors.affiliation: Dipartimento di Chimica Università degli Studi di Roma "Sapienza", P.le A. Moro 5, 00185 Roma, Italy.
authors.forename: Luciano
authors.initials: L
authors.lastname: Galantini
authors.affiliation: CNR, Istituto di Metodologie Chimiche and Dipartimento di Chimica Università degli Studi di Roma "Sapienza", P.le A. Moro 5, 00185 Roma, Italy.
authors.forename: Luisa
authors.initials: L
authors.lastname: Giansanti
authors.affiliation: Dipartimento di Ingegneria Chimica, Materiali, Ambiente Università degli Studi di Roma "Sapienza", P.le A. Moro 5, 00185 Roma, Italy.
authors.forename: Marco
authors.initials: M
authors.lastname: Ierino
authors.affiliation: CNR, Istituto di Metodologie Chimiche and Dipartimento di Chimica Università degli Studi di Roma "Sapienza", P.le A. Moro 5, 00185 Roma, Italy. Electronic address: giovanna.mancini@uniroma1.it.
authors.forename: Giovanna
authors.initials: G
authors.lastname: Mancini
authors.affiliation: Dipartimento di Chimica Università degli Studi di Roma "Sapienza", P.le A. Moro 5, 00185 Roma, Italy.
authors.forename: Alessandra
authors.initials: A
authors.lastname: Muschietti
authors.affiliation: Dipartimento di Chimica Università degli Studi di Roma "Sapienza", P.le A. Moro 5, 00185 Roma, Italy.
authors.forename: Claudio
authors.initials: C
authors.lastname: Sperduto
mesh_terms: D002627:Chemistry, Physical; D015394:Molecular Structure; D011759:Pyrrolidines / Q000138:chemical synthesis* / Q000737:chemistry*; D013501:Surface-Active Agents / Q000138:chemical synthesis* / Q000737:chemistry*
chemical_list: D011759:Pyrrolidines; D013501:Surface-Active Agents