title: Butyrolactone and cycloheptanetrione from mangrove-associated fungus Aspergillus terreus.
abstract: A new butyrolactone, 7″-hydroxybutyrolactone III (1) and three new cycloheptanetriones, terretrione A-C (2-4), together with five known compounds, butyrolactone I, cyclo(Leu-Pro), cyclo(Val-Pro), cyclo(Ile-Pro), cyclo(Phe-Pro), were isolated from mangrove-associated marine fungus Aspergillus terreus. The structures of these compounds were elucidated on the basis of physical data analysis (NMR, high resolution-electrospray ionization (HR-ESI)-MS), especially by 2D-NMR techniques. These compounds showed weak cytotoxicity in vitro against HCT-8, Bel-7402, BGC-823, A2780 cell lines.
authors.affiliation: State Key Laboratory of Bioactive Substance and Function of Natural Medicines & Key Laboratory of Biosynthesis of Natural Products, Ministry of Public Health, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, P. R. China.
authors.forename: Yi
authors.initials: Y
authors.lastname: Shen
authors.forename: Jianhua
authors.initials: J
authors.lastname: Zou
authors.forename: Dan
authors.initials: D
authors.lastname: Xie
authors.forename: Hanlin
authors.initials: H
authors.lastname: Ge
authors.forename: Xiuping
authors.initials: X
authors.lastname: Cao
authors.forename: Jungui
authors.initials: J
authors.lastname: Dai
mesh_terms: D015107:4-Butyrolactone / Q000031:analogs & derivatives* / Q000302:isolation & purification / Q000494:pharmacology; D000970:Antineoplastic Agents / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D001230:Aspergillus / Q000737:chemistry*; D001381:Azepines; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D009369:Neoplasms / Q000188:drug therapy; D021241:Spectrometry, Mass, Electrospray Ionization; D014334:Tropolone / Q000031:analogs & derivatives* / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology
chemical_list: D000970:Antineoplastic Agents; D001381:Azepines; C579487:terretrione A; C579488:terretrione B; C579486:terretrione C; D014334:Tropolone; D015107:4-Butyrolactone