title: [Study on the changes of fibronectin in the resected medial rectus of patients with concomitant exotropia].
abstract: OBJECTIVE
  To study the changes of fibronectin in the resected medial rectus muscles in patients with concomitant exotropia and to have a better understanding about the pathomorphological changes of extraocular muscles in the genesis and development of concomitant exotropia.
  
  
  METHODS
  Thirty-five concomitant exotropic patients were chosen as exotropic group and 20 normals were selected as control group. In the exotropic group, the age range 2 to 46 years old (mean, 20.9 ys), deviation range -45(Δ) to -90(Δ) (mean, -67.5(Δ)), 19 males, 16 females, and 8 cases have the family history. Exotropic patients were divided into intermittent exotropic group 16 cases and constant exotropic group 19 cases. In the control group, the age range 15 - 28 years old (mean, 18.8 years), 12 males and 8 females. All the resected tissues of the medial rectus muscles were obtained from patients with concomitant exotropia during resection surgery and cornea donators. Fibronectin was measured its mean average optical by Sp method of immunohistochemistry using image analyzer. The amounts of fibronectin in the resected muscle of patients were compared with normals, as well as correlated clinical data of patients such as different types of exotropia, age, degree of deviation, gender and positive family history.
  
  
  RESULTS
  The amounts of fibronectin in the resected medial rectus muscle of patients with constant exotropia (0.4729 ± 0.0872) were significantly lower than those of normals (0.5914 ± 0.0547) and intermittent exotropic group (0.5821 ± 0.0792) respectively (q = 7.0314, 6.1177, P < 0.01), while patients with intermittent exotropia did not show significantly lower amounts of fibronectin than those with normals (q = 0.5271, P > 0.05). Neither gender nor positive family was correlated with the amounts of fibronectin (t = 1.1317, 1.6327, P > 0.05) and the amounts of fibronectin had no correlation with age and degree of deviation.
  
  
  CONCLUSIONS
  The amounts of fibronectin were correlated with the course of development of concomitant exotropia. Some of these changes may play a role in the pathogenesis of exotropia from intermittence to constancy, which indicates a further clue to the nature of this disease.
authors.affiliation: Department of Ophthalmology, Qingdao University School of Medical, Yantai, China.
authors.forename: Xu-hong
authors.initials: XH
authors.lastname: Zuo
authors.forename: Gui-xiang
authors.initials: GX
authors.lastname: Liu
mesh_terms: D000293:Adolescent; D000328:Adult; D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D005099:Exotropia / Q000378:metabolism* / Q000473:pathology / Q000503:physiopathology; D005260:Female; D005353:Fibronectins / Q000378:metabolism*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009801:Oculomotor Muscles / Q000378:metabolism*; D055815:Young Adult
chemical_list: D005353:Fibronectins