title: Hyperhomocysteinaemia predicts the decline in pulmonary function in healthy male smokers.
abstract: Hyperhomocysteinaemia is associated with chronic obstructive pulmonary disease. However, the relationship between plasma homocysteine levels and spirometric measures has not been investigated in a general population. We aimed to determine whether homocysteine levels are predictive for a rapid decline in lung function among healthy current smokers. Blood sampling and spirometry were performed on subjects participating in a community-based annual health check in Takahata, Japan, from 2004 to 2006 (n=3257). Spirometry was re-evaluated in 147 male current smokers in 2009. On initial assessment, forced vital capacity (FVC) % predicted and forced expiratory volume in 1 s (FEV1) % predicted correlated inversely with homocysteine levels and were predictive for homocysteine levels, independent of various clinical factors. Homocysteine levels were higher in subjects with restrictive, obstructive or mixed ventilatory disorders. In addition, homocysteine levels were higher in subjects with mixed ventilatory disorders, compared with restrictive or obstructive disorders. On follow-up, subjects showing a decline in FEV1 had higher homocysteine levels than those who did not. Logistic regression analysis indicated that homocysteine levels were predictive for a decline in FEV1. FVC % pred and FEV1 % pred were significantly associated with homocysteine levels, and hyperhomocysteinaemia predicted the annual rate of decline in FEV1 among male smokers.
authors.affiliation: Dept of Cardiology, Pulmonology and Nephrology, Yamagata University School of Medicine, Yamagata, Japan.
authors.forename: Keiko
authors.initials: K
authors.lastname: Nunomiya
authors.forename: Yoko
authors.initials: Y
authors.lastname: Shibata
authors.forename: Shuichi
authors.initials: S
authors.lastname: Abe
authors.forename: Sumito
authors.initials: S
authors.lastname: Inoue
authors.forename: Akira
authors.initials: A
authors.lastname: Igarashi
authors.forename: Keiko
authors.initials: K
authors.lastname: Yamauchi
authors.forename: Yasuko
authors.initials: Y
authors.lastname: Aida
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Kishi
authors.forename: Masamichi
authors.initials: M
authors.lastname: Sato
authors.forename: Tetsu
authors.initials: T
authors.lastname: Watanabe
authors.forename: Tsuneo
authors.initials: T
authors.lastname: Konta
authors.forename: Yoshiyuki
authors.initials: Y
authors.lastname: Ueno
authors.forename: Takeo
authors.initials: T
authors.lastname: Kato
authors.forename: Hidetoshi
authors.initials: H
authors.lastname: Yamashita
authors.forename: Takamasa
authors.initials: T
authors.lastname: Kayama
authors.forename: Isao
authors.initials: I
authors.lastname: Kubota
mesh_terms: D000328:Adult; D000368:Aged; D003430:Cross-Sectional Studies; D005500:Follow-Up Studies; D005541:Forced Expiratory Volume; D006710:Homocysteine / Q000097:blood; D006801:Humans; D020138:Hyperhomocysteinemia / Q000503:physiopathology*; D007564:Japan; D008297:Male; D008875:Middle Aged; D012372:ROC Curve; D012044:Regression Analysis; D012129:Respiratory Function Tests; D012907:Smoking / Q000009:adverse effects; D013147:Spirometry / Q000379:methods; D014797:Vital Capacity
chemical_list: D006710:Homocysteine