title: Self-collection of foam nasal swabs for respiratory virus detection by PCR among immunocompetent subjects and hematopoietic cell transplant recipients.
abstract: Self-collected foam nasal swabs (NS) obtained after instillation of saline spray were compared with nasal washes from immunocompetent subjects during 146 upper respiratory infections (URIs); the sensitivities for reverse transcription (RT)-PCR respiratory virus detection were 95% and 88%, respectively (P = 0.06). The sensitivities from NS collected with and without saline spray during 142 URIs from immunocompetent subjects were 96% and 86% (P = 0.004), respectively, and those from 140 URI samples from hematopoietic cell transplantation recipients were 88% and 85% (P = 0.56), respectively.
authors.affiliation: University of Washington, Seattle, Washington, USA. apeck@fhcrc.org
authors.forename: Angela P
authors.initials: AP
authors.lastname: Campbell
authors.forename: Jane
authors.initials: J
authors.lastname: Kuypers
authors.forename: Janet A
authors.initials: JA
authors.lastname: Englund
authors.forename: Katherine A
authors.initials: KA
authors.lastname: Guthrie
authors.forename: Lawrence
authors.initials: L
authors.lastname: Corey
authors.forename: Michael
authors.initials: M
authors.lastname: Boeckh
mesh_terms: D000328:Adult; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D009666:Nose / Q000821:virology*; D016133:Polymerase Chain Reaction / Q000379:methods*; D012141:Respiratory Tract Infections / Q000821:virology*; D012646:Self Administration; D012680:Sensitivity and Specificity; D013048:Specimen Handling / Q000379:methods*; D014180:Transplantation; D014777:Virus Diseases / Q000175:diagnosis* / Q000821:virology; D014780:Viruses / Q000145:classification / Q000235:genetics / Q000302:isolation & purification*