title: TPT1/ TCTP-regulated pathways in phenotypic reprogramming.
abstract: Evolutionary conserved and pleiotropic, the TPT1/TCTP gene (translationally controlled tumor protein, also called HRF, fortilin), encodes a highly structured mRNA shielded by ribonucleoproteins and closely resembling viral particles. This mRNA activates, as do viruses, protein kinase R (PKR). The TPT1/TCTP protein is structurally similar to mRNA-helicases and MSS4. TPT1/TCTP has recently been identified as a prognostic factor in breast cancer and a critical regulator of the tumor suppressor p53 and of the cancer stem cell (SC) compartment. Emerging evidence indicates that TPT1/TCTP is key to phenotypic reprogramming, as shown in the process of tumor reversion and possibly in pluripotency. We provide here an overview of these diverse functions of TPT1/TCTP.
authors.affiliation: CNRS-UMR 8113, LBPA, École Normale Supérieure, 94235 Cachan, France.
authors.forename: Robert
authors.initials: R
authors.lastname: Amson
authors.forename: Salvatore
authors.initials: S
authors.lastname: Pece
authors.forename: Jean-Christophe
authors.initials: JC
authors.lastname: Marine
authors.forename: Pier Paolo
authors.initials: PP
authors.lastname: Di Fiore
authors.forename: Adam
authors.initials: A
authors.lastname: Telerman
mesh_terms: D014408:Biomarkers, Tumor / Q000235:genetics / Q000378:metabolism; D058685:Genetic Pleiotropy; D006801:Humans; D014411:Neoplastic Stem Cells; D012333:RNA, Messenger / Q000235:genetics*; D012261:Ribonucleoproteins / Q000235:genetics / Q000378:metabolism; D000090324:Tumor Protein, Translationally-Controlled 1; D016159:Tumor Suppressor Protein p53 / Q000235:genetics / Q000378:metabolism; D019892:eIF-2 Kinase / Q000235:genetics / Q000378:metabolism
chemical_list: D014408:Biomarkers, Tumor; D012333:RNA, Messenger; D012261:Ribonucleoproteins; C000715647:TPT1 protein, human; D000090324:Tumor Protein, Translationally-Controlled 1; D016159:Tumor Suppressor Protein p53; D019892:eIF-2 Kinase