title: Roles of peptidoglycan recognition protein (PGRP) in immunity and implications for novel anti-infective measures.
abstract: Peptidoglycan recognition protein (PGRP) is an important host innate immunity arm capable of peptidoglycan and allied bacteria recognition. PGRP belongs to host pattern recognition receptors (PRRs) responsible for pathogen associated molecular patterns recognition, such as lipopolysaccharide, lipoteichoic acid, PGN, and mannose. As an essential host PRR, PGRP is well conserved from insects to mammals. The distribution, structure, function, regulation of gene expression, and evolution of PGRP from insects and mammals were summarized to furnish insights into this important molecule family.
authors.affiliation: Institute of Modern Biopharmaceuticals, State Key Laboratory Breeding Base of Eco-Environment and Bio-Resource of the Three Gorges Area, School of Life Sciences, Southwest University, Beibei, Chongqing 400715, China.
authors.forename: Zhen
authors.initials: Z
authors.lastname: Zhang
authors.forename: Quanxin
authors.initials: Q
authors.lastname: Long
authors.forename: Jianping
authors.initials: J
authors.lastname: Xie
mesh_terms: D000581:Amidohydrolases / Q000378:metabolism; D000818:Animals; D001419:Bacteria / Q000276:immunology; D002352:Carrier Proteins / Q000235:genetics / Q000276:immunology* / Q000378:metabolism*; D004156:Catechol Oxidase / Q000378:metabolism; D004792:Enzyme Precursors / Q000378:metabolism; D005786:Gene Expression Regulation; D006801:Humans; D007113:Immunity, Innate; D007313:Insecta / Q000276:immunology; D008070:Lipopolysaccharides / Q000378:metabolism; D008358:Mannose / Q000378:metabolism; D010457:Peptidoglycan / Q000378:metabolism; D051192:Receptors, Pattern Recognition / Q000235:genetics / Q000276:immunology* / Q000378:metabolism; D015398:Signal Transduction; D013682:Teichoic Acids / Q000378:metabolism
chemical_list: D002352:Carrier Proteins; D004792:Enzyme Precursors; D008070:Lipopolysaccharides; D010457:Peptidoglycan; D051192:Receptors, Pattern Recognition; D013682:Teichoic Acids; C118897:peptidoglycan recognition protein; C009900:lipoteichoic acid; C038451:pro-phenoloxidase; D004156:Catechol Oxidase; D000581:Amidohydrolases; C019665:amidase; D008358:Mannose