title: Can EEG characteristics predict development of epilepsy in autistic children?
abstract: BACKGROUND
  The high occurrence of epilepsy in children with autism spectrum disorders (ASD) is a clear indication that ASD has a neurobiological basis. The current understanding of the association between epilepsy and ASD is still limited, but from a clinical point of view, this association should not be overlooked.
  
  
  OBJECTIVE
  We investigated the electroencephalogram (EEG) paroxysmal abnormality in children with ASD and the incidence of later development of epilepsy.
  
  
  METHODS
  Participants were recruited from University of Yamanashi hospital and 5 satellite hospitals between April 1, 2001 and March 31, 2005. EEG recordings and clinical evaluations were performed every 6 months for at least 6 years, focusing on paroxysmal abnormality. We scored the occurrence and the location of spikes and evaluated the relation with later development of epilepsy.
  
  
  RESULTS
  The prospective study included 21 patients with ASD (12 males and 9 females) between the ages of 3 and 6 years. EEG paroxysmal abnormalities were present in 11/21 patients (52.4%). In addition, six of 21 patients (28.6%) had epilepsy at some point in their lives. The presence of frontal paroxysms was significantly associated with later development of epilepsy compared with centrotemporal paroxysmus (p < 0.003). The type of seizure diagnosed was mainly partial; in particular, partial with secondary generalization in 4/6 (66.7%).
  
  
  CONCLUSIONS
  The presence of frontal paroxysms may indicate a higher risk of epilepsy in ASD.
authors.affiliation: Department of Paediatrics, Faculty of Medicine, University of Yamanashi, Chuo, Yamanashi, Japan. ykimu@yamanashi.ac.jp
authors.forename: Hideaki
authors.initials: H
authors.lastname: Kanemura
authors.forename: Fumikazu
authors.initials: F
authors.lastname: Sano
authors.forename: Tomoko
authors.initials: T
authors.lastname: Tando
authors.forename: Kanji
authors.initials: K
authors.lastname: Sugita
authors.forename: Masao
authors.initials: M
authors.lastname: Aihara
mesh_terms: D001321:Autistic Disorder / Q000453:epidemiology / Q000503:physiopathology*; D002648:Child; D002675:Child, Preschool; D015897:Comorbidity; D004569:Electroencephalography / Q000379:methods*; D004827:Epilepsy / Q000453:epidemiology / Q000503:physiopathology*; D005260:Female; D005625:Frontal Lobe / Q000503:physiopathology; D006801:Humans; D008607:Intellectual Disability / Q000175:diagnosis / Q000503:physiopathology; D007564:Japan; D008297:Male; D011237:Predictive Value of Tests; D011446:Prospective Studies; D012306:Risk