title: [Delayed graft function after DCD kidney transplantation: risk factors for and impact on transplantation].
abstract: OBJECTIVE
  To evaluate the risk factors of delayed graft function (DGF) and its impact on renal transplantation from donation after cardiac death (DCD).
  
  
  METHODS
  We conducted a retrospective study consisting of 48 subjects who underwent a DCD kidney transplantation from February 2010 to March 2012. We classified the recipients into two groups: an IGF (immediate graft function) group (n=30) and a DGF group (n=18), and analyzed the risk factors of DGF and its impact on transplantation.
  
  
  RESULTS
  DGF occurred in 18 of the 48 (37.5%) kidneys from DCD donors, and the occurrence of DGF did not adversely influence the survival of patients (P=0.098) and graft (P=0.447). In the univariate analysis, the preoperative dialysis time of recipients (P<0.001), HLA mismatch site (P<0.001), the cause of brain death (P=0.011), BMI (P<0.001), preoperative serum creatinine of donors (P=0.0001), norepinephrine used in donors (P<0.001), warm ischema time (WIT) (P<0.001), cold ischema time (CIT) (P<0.001) showed significant differences. In the multivariate analysis, cerebral hemorrhage as the cause of brain death (P=0.022, OR=39.652), preoperative serum creatinine of donors≥177 μmol/L (P=0.008, OR=57.148) and the preoperative dialysis time of recipients≥12 months (P=0.060, OR=15.060) were independent risk factors for DGF development.
  
  
  CONCLUSIONS
  The independent risk factors for DGF are the cause of brain death, the terminal creatinine level, and the preoperative dialysis time.
authors.affiliation: Central South University, Changsha, China.
authors.forename: Mingjie
authors.initials: M
authors.lastname: Shao
authors.forename: Qifa
authors.initials: Q
authors.lastname: Ye
authors.forename: Yingzi
authors.initials: Y
authors.lastname: Ming
authors.forename: Xingguo
authors.initials: X
authors.lastname: She
authors.forename: Hong
authors.initials: H
authors.lastname: Liu
authors.forename: Shaojun
authors.initials: S
authors.lastname: Ye
authors.forename: Ying
authors.initials: Y
authors.lastname: Niu
mesh_terms: D001926:Brain Death; D003404:Creatinine / Q000097:blood; D051799:Delayed Graft Function; D006085:Graft Survival; D006801:Humans; D007668:Kidney / Q000503:physiopathology*; D016030:Kidney Transplantation; D015999:Multivariate Analysis; D006435:Renal Dialysis; D012189:Retrospective Studies; D012307:Risk Factors; D013997:Time Factors; D014019:Tissue Donors
chemical_list: D003404:Creatinine