title: Antidiabetic Effects of Add-On Gynostemma pentaphyllum Extract Therapy with Sulfonylureas in Type 2 Diabetic Patients.
abstract: Aims. To investigate the antidiabetic effect of the traditional Vietnamese herb Gynostemma pentaphyllum (GP) together with sulfonylurea (SU) in 25 drug-naïve type 2 diabetic patients. Methods. After 4-week treatment with gliclazide (SU), 30 mg daily, all patients were randomly assigned into 2 groups to add on GP extract or placebo extract, 6 g daily, during eight weeks. Results. After 4-week SU treatment, fasting plasma glucose (FPG) and HbA(1C) decreased significantly (P < 0.001). FPG was further reduced after add-on therapy with 2.9 ± 1.7 and 0.9 ± 0.6 mmol/L in the GP and placebo groups, respectively (P < 0.001). Therapy with GP extract also reduced 30- and 120-minute oral glucose tolerance test postload values. HbA(1C) levels decreased approximately 2% units in the GP group compared to 0.7% unit in the placebo group (P < 0.001). Conclusion. GP extract in addition to SU offers an alternative to addition of other oral medication to treat type 2 diabetic patients.
authors.affiliation: Endocrine and Diabetes Unit, Department of Molecular Medicine and Surgery, Karolinska Institute,17176 Stockholm, Sweden ; Hanoi Medical University, 1000 Hanoi, Vietnam ; National Institute of Gerontology, 1000 Hanoi, Vietnam.
authors.forename: V T T
authors.initials: VT
authors.lastname: Huyen
authors.forename: D V
authors.initials: DV
authors.lastname: Phan
authors.forename: P
authors.initials: P
authors.lastname: Thang
authors.forename: P T
authors.initials: PT
authors.lastname: Ky
authors.forename: N K
authors.initials: NK
authors.lastname: Hoa
authors.forename: C G
authors.initials: CG
authors.lastname: Ostenson