title: The efficacy of noninvasive hemoglobin measurement by pulse CO-oximetry in neonates.
abstract: OBJECTIVE
  To evaluate clinical applicability of noninvasive hemoglobin (Hb) measurement with a pulse CO-oximeter in neonates.
  
  
  METHODS
  Prospective comparison study.
  
  
  METHODS
  Neonatal ICU.
  
  
  METHODS
  Fifty-six preterm and term infants with median age = 20 days (range = 1-98 days) and median weight = 1,440 g (range = 530-4,230 g).
  
  
  METHODS
  Hb measurements by Pulse CO-Oximetry (Masimo Radical-7) were recorded immediately prior to venous samplings.
  
  
  RESULTS
  The collected data were compared with the corresponding venous Hb level obtained in laboratory testing, and a total of 137 data pairs were analyzed. Noninvasive Hb values measured with a pulse CO-oximeter were significantly correlated with the venous Hb levels (correlation coefficient, r = 0.758; p < 0.001). Hb values measured with a pulse CO-oximeter were higher than those measured with a laboratory hematology analyzer (13.3 ± 2.6g/dL vs. 12.5 ± 3.1g/dL). In terms of the agreement between the laboratory analyzer and the pulse CO-oximeter, 94.8% of the measurements fell within two standard deviations of the mean difference.
  
  
  CONCLUSIONS
  Noninvasive Hb measurements with Pulse CO-Oximetry provide clinically acceptable accuracy, and they were significantly correlated with laboratory Hb measurement in neonates. In terms of the clinical applicability, noninvasive Hb monitoring with a pulse CO-oximeter could be useful in the early detection of Hb changes in neonates.
authors.affiliation: Department of Pediatrics, Seoul National University College of Medicine, Seoul, Republic of Korea.
authors.forename: Young Hwa
authors.initials: YH
authors.lastname: Jung
authors.forename: Juyoung
authors.initials: J
authors.lastname: Lee
authors.forename: Han-Suk
authors.initials: HS
authors.lastname: Kim
authors.forename: Seung Han
authors.initials: SH
authors.lastname: Shin
authors.forename: Jin A
authors.initials: JA
authors.lastname: Sohn
authors.forename: Ee-Kyung
authors.initials: EK
authors.lastname: Kim
authors.forename: Jung-Hwan
authors.initials: JH
authors.lastname: Choi
mesh_terms: D005260:Female; D006452:Hemoglobinometry / Q000379:methods; D006454:Hemoglobins / Q000032:analysis* / Q000378:metabolism; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007363:Intensive Care Units, Neonatal; D008297:Male; D008991:Monitoring, Physiologic / Q000379:methods; D010092:Oximetry; D018962:Phlebotomy; D011446:Prospective Studies; D018709:Statistics, Nonparametric
chemical_list: D006454:Hemoglobins