title: T helper cell subsets in the development of atopic dermatitis.
abstract: The pathogenesis of atopic dermatitis (AD) requires the orchestration of multiple immune cells that mediate inflammation and tissue remodeling in the skin. T helper cell subsets that secrete specific cytokines have a central role in regulating the inflammatory process. In this review we discuss defined roles for T helper subsets in AD, how the microbiome might impact the development and function of T helper subsets, and animal models that will be useful for testing hypotheses on the interactions of a polarized T-cell response with skin inflammation. Future studies that link these areas will provide important insight into the development of skin inflammation and AD.
authors.affiliation: Indiana University School of Medicine, Indianapolis, IN, USA. turner41@iupui.edu
authors.forename: Matthew J
authors.initials: MJ
authors.lastname: Turner
authors.forename: Jeffrey B
authors.initials: JB
authors.lastname: Travers
authors.forename: Mark H
authors.initials: MH
authors.lastname: Kaplan
mesh_terms: D000818:Animals; D003876:Dermatitis, Atopic / Q000276:immunology*; D004195:Disease Models, Animal; D006801:Humans; D054892:Metagenome / Q000276:immunology*; D006377:T-Lymphocytes, Helper-Inducer / Q000166:cytology / Q000276:immunology* / Q000502:physiology