title: Inhibition of Streptococcus pneumoniae penicillin-binding protein 2x and Actinomadura R39 DD-peptidase activities by ceftaroline.
abstract: Although the rate of acylation of a penicillin-resistant form of Streptococcus pneumoniae penicillin-binding protein 2x (PBP2x) by ceftaroline is 80-fold lower than that of its penicillin-sensitive counterpart, it remains sufficiently high (k(2)/K = 12,600 M(-1) s(-1)) to explain the sensitivity of the penicillin-resistant strain to this new cephalosporin. Surprisingly, the Actinomadura R39 DD-peptidase is not very sensitive to ceftaroline.
authors.affiliation: Centre de Recherches du Cyclotron, Université de Liège, Sart-Tilman, Liège, Belgium. azervosen@ulg.ac.be
authors.forename: Astrid
authors.initials: A
authors.lastname: Zervosen
authors.forename: André
authors.initials: A
authors.lastname: Zapun
authors.forename: Jean-Marie
authors.initials: JM
authors.lastname: Frère
mesh_terms: D000192:Actinomycetales / Q000187:drug effects* / Q000201:enzymology / Q000254:growth & development; D000215:Acylation / Q000187:drug effects; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D002511:Cephalosporins / Q000494:pharmacology*; D007700:Kinetics; D008826:Microbial Sensitivity Tests; D046915:Penicillin-Binding Proteins / Q000037:antagonists & inhibitors* / Q000378:metabolism; D046929:Serine-Type D-Ala-D-Ala Carboxypeptidase / Q000037:antagonists & inhibitors / Q000378:metabolism*; D013045:Species Specificity; D013296:Streptococcus pneumoniae / Q000187:drug effects* / Q000254:growth & development / Q000378:metabolism; D000097583:Ceftaroline
chemical_list: D000900:Anti-Bacterial Agents; D002511:Cephalosporins; D046915:Penicillin-Binding Proteins; D046929:Serine-Type D-Ala-D-Ala Carboxypeptidase; D000097583:Ceftaroline; C072223:PBP 2x protein, Streptococcus