title: An epidemic of Pneumocystis jiroveci pneumonia in a renal transplantation center: role of T-cell lymphopenia.
abstract: Although only 2 cases of Pneumocystis jiroveci pneumonia were observed in our center between 2004 and 2009, we diagnosed 9 cases in 2010. Each patient had been in contact in the hospital with at least 1 other patient suffering P jiroveci pneumonia. Genotyping of P jiroveci pneumonia strains demonstrates a total homogeneity of the DNA sequences in the 7 patients already analyzed. CD4+ lymphocyte count was significantly lower at M3 in P jiroveci pneumonia patients than in controls. Our clinical and molecular data confirm that interhuman transmission of P jiroveci is possible, particularly to lymphopenic transplant recipients.
authors.affiliation: Department of Nephrology and Transplantation, Hôpital Lapeyronie, University of Montpellier, Montpellier, France.
authors.forename: V
authors.initials: V
authors.lastname: Brunot
authors.forename: V
authors.initials: V
authors.lastname: Pernin
authors.forename: C
authors.initials: C
authors.lastname: Chartier
authors.forename: V
authors.initials: V
authors.lastname: Garrigue
authors.forename: F
authors.initials: F
authors.lastname: Vetromile
authors.forename: I
authors.initials: I
authors.lastname: Szwarc
authors.forename: S
authors.initials: S
authors.lastname: Delmas
authors.forename: P
authors.initials: P
authors.lastname: Portalès
authors.forename: D
authors.initials: D
authors.lastname: Basset
authors.forename: G
authors.initials: G
authors.lastname: Mourad
mesh_terms: D018791:CD4 Lymphocyte Count; D016009:Chi-Square Distribution; D003428:Cross Infection / Q000453:epidemiology* / Q000276:immunology / Q000382:microbiology / Q000628:therapy / Q000635:transmission; D058872:Epidemics; D005602:France / Q000453:epidemiology; D005838:Genotype; D006801:Humans; D016030:Kidney Transplantation / Q000009:adverse effects / Q000276:immunology*; D008231:Lymphopenia / Q000276:immunology*; D045363:Pneumocystis carinii / Q000235:genetics / Q000472:pathogenicity*; D011020:Pneumonia, Pneumocystis / Q000453:epidemiology* / Q000276:immunology / Q000382:microbiology / Q000628:therapy / Q000635:transmission; D012189:Retrospective Studies; D012307:Risk Factors; D013601:T-Lymphocytes / Q000276:immunology*; D013997:Time Factors