title: Anal bulking agents for faecal incontinence.
abstract: The aim of this review was to assess and evaluate reports of studies on the efficacy of anal bulking agents used in the treatment of faecal incontinence. A systematic review of the literature was carried out to identify studies that have reported on the use of anal bulking agents. A variety of biomaterials have been employed for anal bulking. These include autologous fat, bovine glutaraldehyde cross-linked collagen, carbon-coated zirconium oxide beads, dextranomer microspheres in a gel, hydrogel cross-linked with polyacrylamide, polydimethylsiloxane elastomer in a gel, porcine dermal collagen and synthetic calcium hydroxylapatitie ceramic microspheres. Although the ideal site of injection (submucosal or intramuscular) and the mechanism of action remain the subject of debate, most published studies report a significant improvement in continence in at least 50% of subjects with mild to moderate symptoms with little or no associated morbidity.We concluded that anal bulking agents may be used to alleviate symptoms of faecal seepage and soilage.
authors.affiliation: The John Goligher Colorectal Unit, St James's University Hospital, Leeds, UK.
authors.forename: N F S
authors.initials: NF
authors.lastname: Watson
authors.forename: A
authors.initials: A
authors.lastname: Koshy
authors.forename: P M
authors.initials: PM
authors.lastname: Sagar
mesh_terms: D001003:Anal Canal; D001672:Biocompatible Materials / Q000008:administration & dosage*; D005242:Fecal Incontinence / Q000628:therapy*; D006801:Humans; D007267:Injections; D011183:Postoperative Complications; D016896:Treatment Outcome
chemical_list: D001672:Biocompatible Materials