title: Phenylpropanoids and lignanoids from Euonymus acanthocarpus.
abstract: A new phenylpropanoid derivative (1), along with five phenylpropanoids (2-6), two monoepoxy lignans (8-9), one bisepoxy lignan (10), two cyclolignans (11-12), six neolignans (7, 13-17), two mixed lignan-neolignans (18-19), two lignan glycosides (20-21), and four flavonolignans (22-25), were isolated from the stems and twigs of Euonymus acanthocarpus. Compounds 2-3, 6-8, 12, and 14-25 were obtained from Celastraceae family for the first time, and compounds 5 and 9 were isolated from Euonymus genus for the first time. All the compounds were tested for cytotoxicity against SK-OV-3 and MCG-803 human tumor cell lines. Compounds 3, 10, 12, and 18 showed weak cytotoxicity against SK-OV-3 cell line, and compounds 3-4, 10-13, and 19 showed weak cytotoxicity against MCG-803 cell line.
authors.affiliation: School of Pharmacy, Shanghai Jiao Tong University, China.
authors.forename: Jia Xian
authors.initials: JX
authors.lastname: Zhu
authors.forename: Jie
authors.initials: J
authors.lastname: Ren
authors.forename: Jiang Jiang
authors.initials: JJ
authors.lastname: Qin
authors.forename: Xiang Rong
authors.initials: XR
authors.lastname: Cheng
authors.forename: Qi
authors.initials: Q
authors.lastname: Zeng
authors.forename: Fei
authors.initials: F
authors.lastname: Zhang
authors.forename: Shi Kai
authors.initials: SK
authors.lastname: Yan
authors.forename: Hui Zi
authors.initials: HZ
authors.lastname: Jin
authors.forename: Wei Dong
authors.initials: WD
authors.lastname: Zhang
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000302:isolation & purification* / Q000494:pharmacology; D018929:Cell Culture Techniques; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D002851:Chromatography, High Pressure Liquid; D002942:Circular Dichroism; D029756:Euonymus / Q000737:chemistry*; D006801:Humans; D017705:Lignans / Q000302:isolation & purification* / Q000494:pharmacology; D015394:Molecular Structure; D010666:Phenylpropionates / Q000302:isolation & purification* / Q000494:pharmacology; D018547:Plant Stems / Q000737:chemistry; D017550:Spectroscopy, Fourier Transform Infrared
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D017705:Lignans; D010666:Phenylpropionates