title: Atomoxetine increases fronto-parietal functional MRI activation in attention-deficit/hyperactivity disorder: a pilot study.
abstract: We hypothesized that atomoxetine (ATMX) would produce similar brain effects in attention-deficit/hyperactivity disorder (ADHD) as those of methylphenidate (MPH). Eleven ADHD adults performed the Multi-Source Interference Task (MSIT) during functional magnetic resonance imaging (fMRI) at baseline and after 6 weeks of ATMX treatment. ATMX was associated with increased fMRI activation of dorsolateral prefrontal cortex, parietal cortex and cerebellum but not dorsal anterior midcingulate cortex (daMCC). These results suggest that ATMX and MPH have similar but not identical brain effects.
authors.affiliation: Harvard Medical School, Department of Psychiatry, Boston, MA 02114, USA.
authors.forename: George
authors.initials: G
authors.lastname: Bush
authors.forename: Jennifer
authors.initials: J
authors.lastname: Holmes
authors.forename: Lisa M
authors.initials: LM
authors.lastname: Shin
authors.forename: Craig
authors.initials: C
authors.lastname: Surman
authors.forename: Nikos
authors.initials: N
authors.lastname: Makris
authors.forename: Eric
authors.initials: E
authors.lastname: Mick
authors.forename: Larry J
authors.initials: LJ
authors.lastname: Seidman
authors.forename: Joseph
authors.initials: J
authors.lastname: Biederman
mesh_terms: D018759:Adrenergic Uptake Inhibitors / Q000494:pharmacology* / Q000627:therapeutic use; D000328:Adult; D000069445:Atomoxetine Hydrochloride; D001289:Attention Deficit Disorder with Hyperactivity / Q000188:drug therapy / Q000503:physiopathology*; D005625:Frontal Lobe / Q000187:drug effects* / Q000503:physiopathology; D006801:Humans; D008279:Magnetic Resonance Imaging; D009415:Nerve Net / Q000187:drug effects* / Q000503:physiopathology; D010296:Parietal Lobe / Q000187:drug effects* / Q000503:physiopathology; D010865:Pilot Projects; D011437:Propylamines / Q000494:pharmacology* / Q000627:therapeutic use
chemical_list: D018759:Adrenergic Uptake Inhibitors; D011437:Propylamines; D000069445:Atomoxetine Hydrochloride