title: [Interdisciplinary AWMF guideline for the treatment of primary antibody deficiencies].
abstract: BACKGROUND
  Currently, management of antibody deficient patients differs significantly among caregivers. Evidence and consensus based (S3) guidelines for the treatment of primary antibody deficiencies were developed to improve the management of these patients.
  
  
  METHODS
  Based on a thorough analysis of current evidence (systematic literature search in PubMed; deadline November 2011) 14 recommendations were finalized during a consensus meeting in Frankfurt in November 2011 using structured consensus methods (nominal group technique). Experts were nominated by their scientific societies/patient initiatives (Tab. 1).
  
  
  RESULTS
  The guidelines focus on indication, practical issues and monitoring of immunoglobulin replacement therapy as well as on different routes of administration. Furthermore recommendations regarding supportive measures such as antiinfective therapy, vaccinations and physiotherapy are given. Combining literature evidence and experience of caregivers within this evidence and consensus based guidelines offers the chance to improve the quality of care for anti-body deficient patients.
authors.affiliation: Abteilung für Pneumologie, HELIOS Klinkum Krefeld.
authors.forename: J
authors.initials: J
authors.lastname: Krudewig
authors.forename: U
authors.initials: U
authors.lastname: Baumann
authors.forename: H
authors.initials: H
authors.lastname: Bernuth von
authors.forename: M
authors.initials: M
authors.lastname: Borte
authors.forename: U
authors.initials: U
authors.lastname: Burkhard-Meier
authors.forename: G
authors.initials: G
authors.lastname: Dueckers
authors.forename: E
authors.initials: E
authors.lastname: Foerster-Waldl
authors.forename: K
authors.initials: K
authors.lastname: Franke
authors.forename: P
authors.initials: P
authors.lastname: Habermehl
authors.forename: M
authors.initials: M
authors.lastname: Hönig
authors.forename: W
authors.initials: W
authors.lastname: Kern
authors.forename: K
authors.initials: K
authors.lastname: Kösters
authors.forename: K
authors.initials: K
authors.lastname: Kugel
authors.forename: T
authors.initials: T
authors.lastname: Lehrnbecher
authors.forename: J
authors.initials: J
authors.lastname: Liese
authors.forename: R
authors.initials: R
authors.lastname: Marks
authors.forename: G A
authors.initials: GA
authors.lastname: Müller
authors.forename: R
authors.initials: R
authors.lastname: Müller
authors.forename: D
authors.initials: D
authors.lastname: Nadal
authors.forename: H-H
authors.initials: HH
authors.lastname: Peter
authors.forename: D
authors.initials: D
authors.lastname: Pfeiffer-Kascha
authors.forename: M
authors.initials: M
authors.lastname: Schneider
authors.forename: H
authors.initials: H
authors.lastname: Sitter
authors.forename: P
authors.initials: P
authors.lastname: Späth
authors.forename: V
authors.initials: V
authors.lastname: Wahn
authors.forename: T
authors.initials: T
authors.lastname: Welte
authors.forename: T
authors.initials: T
authors.lastname: Niehues
mesh_terms: D000328:Adult; D000890:Anti-Infective Agents / Q000627:therapeutic use; D002675:Child, Preschool; D003131:Combined Modality Therapy; D003299:Cooperative Behavior; D019317:Evidence-Based Medicine; D006801:Humans; D007116:Immunization, Passive; D007153:Immunologic Deficiency Syndromes / Q000628:therapy*; D033183:Interdisciplinary Communication; D026741:Physical Therapy Modalities; D058996:Quality Improvement; D016032:Randomized Controlled Trials as Topic; D014611:Vaccination
chemical_list: D000890:Anti-Infective Agents