title: The pathogenesis of systemic lupus erythematosus-an update.
abstract: Systemic lupus erythematosus (SLE, lupus) is characterized by a global loss of self-tolerance with activation of autoreactive T and B cells leading to production of pathogenic autoantibodies and tissue injury. Innate immune mechanisms are necessary for the aberrant adaptive immune responses in SLE. Recent advances in basic and clinical biology have shed new light on disease mechanisms in lupus, with this review discussing the recent studies that offer valuable insights into disease-specific therapeutic targets.
authors.affiliation: Department of Internal Medicine (Rheumatology), Yale School of Medicine, New Haven, CT 06520, United States.
authors.forename: Jinyoung
authors.initials: J
authors.lastname: Choi
authors.forename: Sang Taek
authors.initials: ST
authors.lastname: Kim
authors.forename: Joe
authors.initials: J
authors.lastname: Craft
mesh_terms: D001323:Autoantibodies / Q000276:immunology; D015551:Autoimmunity / Q000502:physiology; D001402:B-Lymphocytes / Q000276:immunology; D006801:Humans; D007113:Immunity, Innate; D008180:Lupus Erythematosus, Systemic / Q000209:etiology*; D013601:T-Lymphocytes / Q000276:immunology
chemical_list: D001323:Autoantibodies