title: Dexmedetomidine to treat lisdexamfetamine overdose and serotonin toxidrome in a 6-year-old girl.
abstract: A 6-year-old girl displayed symptoms of serotonin syndrome after accidental ingestion of Vyvanse (lisdexamfetamine dimesylate). Dexmedetomidine was administered because of persistent neuromuscular hyperactivity and severe agitation despite initial therapy with benzodiazepines. Some children show a paradoxical reaction to benzodiazepines, and dexmedetomidine has a possible role in the treatment of serotonin syndrome.
authors.affiliation: Department of Pediatrics at Tulane Hospital for Children, New Orleans, Louisiana 70112-2632, USA. oakingbo@tulane.edu
authors.forename: Olugbenga A
authors.initials: OA
authors.lastname: Akingbola
authors.forename: Dinesh
authors.initials: D
authors.lastname: Singh
mesh_terms: D058647:Adrenergic alpha-2 Receptor Agonists / Q000627:therapeutic use*; D014151:Anti-Anxiety Agents / Q000008:administration & dosage / Q000009:adverse effects; D000697:Central Nervous System Stimulants / Q000008:administration & dosage / Q000009:adverse effects*; D002648:Child; D020927:Dexmedetomidine / Q000627:therapeutic use*; D003913:Dextroamphetamine / Q000008:administration & dosage / Q000009:adverse effects*; D062787:Drug Overdose; D005260:Female; D006801:Humans; D000069478:Lisdexamfetamine Dimesylate; D008140:Lorazepam / Q000008:administration & dosage / Q000009:adverse effects; D008874:Midazolam / Q000008:administration & dosage / Q000009:adverse effects; D020230:Serotonin Syndrome / Q000139:chemically induced / Q000188:drug therapy*
chemical_list: D058647:Adrenergic alpha-2 Receptor Agonists; D014151:Anti-Anxiety Agents; D000697:Central Nervous System Stimulants; D020927:Dexmedetomidine; D008140:Lorazepam; D008874:Midazolam; D000069478:Lisdexamfetamine Dimesylate; D003913:Dextroamphetamine