title: Can the incidence of gastric cancer be reduced in the new century?
abstract: Gastric cancer (GC) is one of the most common cancers in the world. The incidence and mortality rate of GC vary among different countries. It is suggested that GC is the result of the interaction between Helicobacter pylori (H. pylori) infection and the genetic and environmental factors in the host. H. pylori infection is the trigger of intestinal gastric adenocarcinoma. The incidence of GC is highest in East Asia and East Europe, but much lower in Africa; however, H. pylori infection is commonly seen in Africa, which is known as the African enigma. The 5-year survival of early GC is far better than that of advanced GC. A high detection rate of early GC could help us to conquer GC. A decreasing trend of GC incidence has been witnessed worldwide. With the improvement of living conditions and the achievements of scientific research, it seems possible that there will be a further reduction in the incidence of GC in the new century.
authors.affiliation: Department of Gastroenterology and Hepatology, Renji Hospital, Shanghai Jiao Tong University School of Medicine Shanghai Institute of Digestive Disease, Shanghai, China.
authors.forename: Ye
authors.initials: Y
authors.lastname: Hu
authors.forename: Jing Yuan
authors.initials: JY
authors.lastname: Fang
authors.forename: Shu Dong
authors.initials: SD
authors.lastname: Xiao
mesh_terms: D000230:Adenocarcinoma / Q000175:diagnosis / Q000453:epidemiology / Q000209:etiology; D055088:Early Detection of Cancer; D016481:Helicobacter Infections / Q000150:complications; D006801:Humans; D015994:Incidence; D013274:Stomach Neoplasms / Q000175:diagnosis / Q000453:epidemiology* / Q000209:etiology; D015996:Survival Rate