title: Studies of mixed liposomes with novel sorbyl functionalized head group lipids.
abstract: Three novel polymerizable amphiphiles with a sorbyl-substituted head group were synthesized and systematically characterized. These amphiphiles are neutral in charge. None of these molecules forms vesicles by itself, presumably due to lack of amphiphilicity and/or extensive head group interaction. Therefore, mixed vesicles were formed with other fluid lipids such as DPenPC, eggPC, or DOPC. We investigated the properties of these mixtures in both vesicles and Langmuir films. The Langmuir isotherms show formation of monolayers by all three molecules. However, the isotherms for mixed monolayers suggest that two components are largely immiscible to the mixing lipid. Under polymerization conditions, mixed vesicles of these amphiphiles form oligomers, suggesting that in spite of a larger head group, they form mesophases.
authors.affiliation: Department of Chemistry and Biochemistry, University of Arizona, Tucson, AZ 85721-0041, United States. saliya@arizona.edu
authors.forename: Saliya N
authors.initials: SN
authors.lastname: Ratnayaka
authors.forename: El Hadj
authors.initials: el H
authors.lastname: Elandaloussi
authors.forename: Bryan D
authors.initials: BD
authors.lastname: Korth
authors.forename: Robert B
authors.initials: RB
authors.lastname: Bates
authors.forename: Jeffrey
authors.initials: J
authors.lastname: Pyun
authors.forename: Henry K
authors.initials: HK
authors.lastname: Hall
authors.forename: S Scott
authors.initials: SS
authors.lastname: Saavedra
mesh_terms: D004075:Diglycerides / Q000138:chemical synthesis / Q000737:chemistry*; D008081:Liposomes / Q000737:chemistry*; D044367:Phase Transition; D010713:Phosphatidylcholines / Q000737:chemistry; D058105:Polymerization; D011412:Propanolamines / Q000138:chemical synthesis / Q000737:chemistry*; D044366:Transition Temperature; D014466:Ultraviolet Rays
chemical_list: D004075:Diglycerides; D008081:Liposomes; D010713:Phosphatidylcholines; D011412:Propanolamines; C037108:1,2-pentadecanoylphosphatidylcholine; C017251:1,2-oleoylphosphatidylcholine