title: Assessment of asthma control and asthma exacerbations in the epidemiology and natural history of asthma: outcomes and treatment regimens (TENOR) observational cohort.
abstract: Patients with severe or difficult-to-treat asthma account for substantial asthma morbidity, mortality, and healthcare burden despite comprising only a small proportion of the total asthma population. TENOR, a multicenter, observational, prospective cohort study was initiated in 2001. It enrolled 4,756 adults, adolescents and children with severe or difficult-to-treat asthma who were followed semi-annually and annually for three years, enabling insight to be gained into this understudied population. A broad range of demographic, clinical, and patient self-reported assessments were completed during the follow-up period. Here, we present key findings from the TENOR registry in relation to asthma control and exacerbations, including the identification of specific subgroups found to be at particularly high-risk. Identification of the factors and subgroups associated with poor asthma control and increased risk of exacerbations can help physicians design individual asthma management, and improve asthma-related health outcomes for these patients.
authors.affiliation: Capital Allergy and Respiratory Disease Center, Sacramento, 5609 J Street, Suite C, Sacramento, CA 95819 USA.
authors.forename: Bradley E
authors.initials: BE
authors.lastname: Chipps
authors.forename: Robert S
authors.initials: RS
authors.lastname: Zeiger
authors.forename: Alejandro
authors.initials: A
authors.lastname: Dorenbaum
authors.forename: Larry
authors.initials: L
authors.lastname: Borish
authors.forename: Sally E
authors.initials: SE
authors.lastname: Wenzel
authors.forename: Dave P
authors.initials: DP
authors.lastname: Miller
authors.forename: Mary Lou
authors.initials: ML
authors.lastname: Hayden
authors.forename: Eugene R
authors.initials: ER
authors.lastname: Bleecker
authors.forename: F Estelle R
authors.initials: FE
authors.lastname: Simons
authors.forename: Stanley J
authors.initials: SJ
authors.lastname: Szefler
authors.forename: Scott T
authors.initials: ST
authors.lastname: Weiss
authors.forename: Tmirah
authors.initials: T
authors.lastname: Haselkorn