title: Effects of intra-aortic balloon pump timing on baroreflex activities in a closed-loop cardiovascular hybrid model.
abstract: Despite 50 years of research to assess the intra-aortic balloon pump (IABP) effects on patients' hemodynamics, some issues related to the effects of this therapy are still not fully understood. One of these issues is the effect of IABP, its inflation timing and duration on peripheral circulation autonomic controls. This work provides a systematic analysis of IABP effects on baroreflex using a cardiovascular hybrid model, which consists of computational and hydraulic submodels. The work also included a baroreflex computational model that was connected to a hydraulic model with a 40-cm(3) balloon. The IABP was operated at different inflation trigger timings (-0.14 to 0.31 s) and inflation durations (0.05-0.45 s), with time of the dicrotic notch being taken as t = 0. Baroreflex-dependent parameters-afferent and efferent pathway activity, heart rate, peripheral resistance, and venous tone-were evaluated at each of the inflation trigger times and durations considered. Balloon early inflation (0.09 s before the dicrotic notch) with inflation duration of 0.25 s generated a maximum net increment of afferent pathway activity of 10%, thus leading to a decrement of efferent sympathetic activity by 15.3% compared with baseline values. These times also resulted in a reduction in peripheral resistance and heart rate by 4 and 4.3% compared with baseline value. We conclude that optimum IABP triggering time results in positive effects on peripheral circulation autonomic controls. Conversely, if the balloon is not properly timed, peripheral resistance and heart rate may even increase, which could lead to detrimental outcomes.
authors.affiliation: Section of Rome, Institute of Clinical Physiology, National Council for Research, Rome, Italy.
authors.forename: Libera
authors.initials: L
authors.lastname: Fresiello
authors.forename: Ashraf William
authors.initials: AW
authors.lastname: Khir
authors.forename: Arianna
authors.initials: A
authors.lastname: Di Molfetta
authors.forename: Maciej
authors.initials: M
authors.lastname: Kozarski
authors.forename: Gianfranco
authors.initials: G
authors.lastname: Ferrari
mesh_terms: D001341:Autonomic Nervous System / Q000503:physiopathology*; D017704:Baroreflex; D001794:Blood Pressure; D002319:Cardiovascular System / Q000294:innervation*; D003198:Computer Simulation; D006333:Heart Failure / Q000503:physiopathology / Q000628:therapy*; D006339:Heart Rate; D006439:Hemodynamics; D006801:Humans; D007423:Intra-Aortic Balloon Pumping / Q000009:adverse effects / Q000379:methods*; D008955:Models, Cardiovascular; D013997:Time Factors; D014655:Vascular Resistance; D016276:Ventricular Function; D017725:Ventricular Pressure