title: IL-15Rα deficiency leads to mitochondrial and myofiber differences in fast mouse muscles.
abstract: The purpose of this study was to determine mitochondrial changes in fast muscles from interleukin-15 receptor alpha knockout (IL-15RαKO) mice. We tested the hypothesis that fast muscles from IL-15RαKO mice would have a greater mitochondrial density and altered internal structure compared to muscles from control mice. In fast muscles from IL-15RαKO mice, mitochondrial density was 48% greater with a corresponding increase in mitochondrial DNA content. Although there were no differences in the relative size of isolated mitochondria, internal complexity was lower in mitochondria from IL-15RαKO mice. These data support an increase in mitochondrial biogenesis and provide direct evidence for a greater density and altered internal structure of mitochondria in EDL muscles deficient in IL-15Rα.
authors.affiliation: Division of Exercise Physiology, West Virginia University School of Medicine, Morgantown, WV 26506, USA. epistilli2@hsc.wvu.edu
authors.forename: Emidio E
authors.initials: EE
authors.lastname: Pistilli
authors.forename: Ge
authors.initials: G
authors.lastname: Guo
authors.forename: William T
authors.initials: WT
authors.lastname: Stauber
mesh_terms: D000818:Animals; D004272:DNA, Mitochondrial / Q000032:analysis / Q000378:metabolism*; D053720:Interleukin-15 Receptor alpha Subunit / Q000172:deficiency* / Q000235:genetics*; D051379:Mice; D018345:Mice, Knockout; D008928:Mitochondria / Q000378:metabolism*; D018656:Muscle Fibers, Fast-Twitch / Q000378:metabolism*
chemical_list: D004272:DNA, Mitochondrial; D053720:Interleukin-15 Receptor alpha Subunit