title: The role of epigenetic transcriptional regulation in BRCA1-mediated tumor suppression.
abstract: Mutation in BRCA1 accounts for half of all familial breast cancer cases. Recent studies have shown its role in the epigenetic regulation of an oncogenic microRNA, revealing a novel mode of tumor suppression that is independent of its well-established role in DNA repair and cell cycle regulation.
authors.affiliation: Dept. of Medicine, Graduate School, University of Ulsan College of Medicine, Asan Institute for Life Science, Songpa-gu, Seoul, Republic of Korea.
authors.forename: Suhwan
authors.initials: S
authors.lastname: Chang
authors.forename: Shyam K
authors.initials: SK
authors.lastname: Sharan
mesh_terms: D019313:BRCA1 Protein / Q000737:chemistry / Q000235:genetics* / Q000378:metabolism*; D001943:Breast Neoplasms / Q000235:genetics* / Q000378:metabolism*; D002352:Carrier Proteins / Q000378:metabolism; D044127:Epigenesis, Genetic; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D035683:MicroRNAs / Q000235:genetics / Q000378:metabolism; D011485:Protein Binding; D054730:Protein Interaction Domains and Motifs; D014158:Transcription, Genetic
chemical_list: D019313:BRCA1 Protein; D002352:Carrier Proteins; D035683:MicroRNAs
keywords: BRCA1; breast cancer; epigenetic regulation; miR-155; micro RNA; transcription