title: Synthesis and pharmacological activity of alkaloids from embryo of lotus, Nelumbo nucifera.
abstract: Bisbenzylisoquinoline alkaloid, nelumboferine which was recently isolated from the embryo of Nelumbo nucifera, and stereoisomers of neferine, which is a major alkaloid of the embryo of N. nucifera, were stereoselectively synthesized. Pharmacological activity of nelumboferine, stereoisomers of neferine, liensinine, isoliensinine, and O-methylneferine were evaluated.
authors.affiliation: Kobe Pharmaceutical University, Kobe 658-8558, Japan. nishi@kobepharma-u.ac.jp
authors.forename: Katsumi
authors.initials: K
authors.lastname: Nishimura
authors.forename: Shinji
authors.initials: S
authors.lastname: Horii
authors.forename: Takao
authors.initials: T
authors.lastname: Tanahashi
authors.forename: Yumi
authors.initials: Y
authors.lastname: Sugimoto
authors.forename: Jun
authors.initials: J
authors.lastname: Yamada
mesh_terms: D000818:Animals; D044182:Benzylisoquinolines / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D004365:Drugs, Chinese Herbal / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D006993:Hypnotics and Sedatives / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D051379:Mice; D009043:Motor Activity / Q000187:drug effects; D031653:Nelumbo / Q000196:embryology*
chemical_list: D044182:Benzylisoquinolines; D004365:Drugs, Chinese Herbal; D006993:Hypnotics and Sedatives; C057222:neferine