title: PillCam colon capsule endoscopy versus conventional colonoscopy for the detection of severity and extent of ulcerative colitis.
abstract: OBJECTIVE
  To evaluate PillCam colon capsule endoscopy (PCCE) in detecting the severity and extent of active ulcerative colitis (UC), in comparison with conventional endoscopy.
  
  
  METHODS
  From July 2009 to June 2012, patients with confirmed UC were enrolled in this prospective single-center study. After they had undergone the PCCE, they received a conventional colonoscopy. The extent of mucosal damage and inflammatory lesions during both procedures was recorded for comparison. In addition, the regimen of bowel preparation, completion rate, colonic cleansing, compliance or adverse events were analyzed.
  
  
  RESULTS
  A total of 26 patients was consecutively included, among whom one was withdrawn. The remaining 25 (nine females and 16 males with a mean age of 44.2 years) completed the study. There was significant correlation in the severity (κ = 0.751, P < 0.001) and extent (κ = 0.522, P < 0.001) of UC between the PCCE and conventional colonoscopy. In addition, the excellent to good rate of colonic cleanliness in PCCE was 80%. There were no remarkable adverse events during the study.
  
  
  CONCLUSIONS
  PCCE provides an outstanding performance in the detection of the severity and extent of active UC.
authors.affiliation: Department of Gastroenterology, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai Institute of Digestive Disease, Shanghai, China.
authors.forename: Chen An
authors.initials: CA
authors.lastname: Ye
authors.forename: Yun Jie
authors.initials: YJ
authors.lastname: Gao
authors.forename: Zhi Zheng
authors.initials: ZZ
authors.lastname: Ge
authors.forename: Jun
authors.initials: J
authors.lastname: Dai
authors.forename: Xiao Bo
authors.initials: XB
authors.lastname: Li
authors.forename: Han Bing
authors.initials: HB
authors.lastname: Xue
authors.forename: Zhi Hua
authors.initials: ZH
authors.lastname: Ran
authors.forename: Yun Jia
authors.initials: YJ
authors.lastname: Zhao
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D053704:Capsule Endoscopy / Q000009:adverse effects / Q000379:methods*; D002400:Cathartics; D003093:Colitis, Ulcerative / Q000175:diagnosis*; D003113:Colonoscopy / Q000009:adverse effects / Q000379:methods*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D012720:Severity of Illness Index; D016037:Single-Blind Method; D055815:Young Adult
chemical_list: D002400:Cathartics