title: IgG4-related disease underlying the pathogenesis of coronary artery disease.
abstract: Immunoglobulin G4 (IgG4)-related disease is a newly emerging clinicopathological entity that is characterized by increased serum IgG4 levels and tissue infiltration of IgG4-positive plasma cells. IgG4-related immune inflammation has been reported to be present in inflammatory aortic aneurysm, albeit not in every case. Several recent studies have suggested that IgG4-related disease may underlie certain coronary artery abnormalities, such as coronary aneurysm, pseudotumor, wall calcification, and intimal thickening. Here, what is known about IgG4-related coronary artery lesions, as well as questions that remain to be answered thus far, are discussed.
authors.affiliation: Department of Cardiology, Osaka Medical College, Osaka, Japan. ishizaka@poh.osaka-med.ac.jp
authors.forename: Nobukazu
authors.initials: N
authors.lastname: Ishizaka
mesh_terms: D015415:Biomarkers / Q000097:blood; D002465:Cell Movement / Q000276:immunology; D003323:Coronary Aneurysm / Q000000981:diagnostic imaging / Q000276:immunology / Q000473:pathology; D017023:Coronary Angiography; D003324:Coronary Artery Disease / Q000000981:diagnostic imaging / Q000276:immunology* / Q000473:pathology*; D003331:Coronary Vessels / Q000000981:diagnostic imaging / Q000276:immunology* / Q000473:pathology*; D006104:Granuloma, Plasma Cell / Q000000981:diagnostic imaging / Q000276:immunology / Q000473:pathology; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood / Q000276:immunology*; D007249:Inflammation / Q000000981:diagnostic imaging / Q000276:immunology / Q000473:pathology; D010950:Plasma Cells / Q000000981:diagnostic imaging / Q000276:immunology / Q000473:pathology; D017539:Tunica Intima / Q000000981:diagnostic imaging / Q000276:immunology / Q000473:pathology
chemical_list: D015415:Biomarkers; D007074:Immunoglobulin G