title: A unique host defense pathway: TRIF mediates both antiviral and antibacterial immune responses.
abstract: Both anti-viral and anti-bacterial host defense mechanisms involve TRIF signaling. TRIF provides early clearance of pathogens and coordination of a local inflammatory ensemble through an interferon cascade, while it may trigger organ damage. The multipotentiality of TRIF-mediated immune machinery may direct the fate of our continuous battle with microbes.
authors.affiliation: Division of Gastroenterology, Department of Medicine, University of Miami Miller School of Medicine, Miami, FL 33101, USA.
authors.forename: Jinhee
authors.initials: J
authors.lastname: Hyun
authors.forename: Saravana
authors.initials: S
authors.lastname: Kanagavelu
authors.forename: Masayuki
authors.initials: M
authors.lastname: Fukata
mesh_terms: D033942:Adaptor Proteins, Vesicular Transport / Q000276:immunology*; D001424:Bacterial Infections / Q000276:immunology*; D054884:Host-Pathogen Interactions; D006801:Humans; D007113:Immunity, Innate; D051193:Toll-Like Receptors / Q000276:immunology*; D014777:Virus Diseases / Q000276:immunology*
chemical_list: D033942:Adaptor Proteins, Vesicular Transport; C470409:TICAM1 protein, human; D051193:Toll-Like Receptors