title: [The role of adult bone marrow derived mesenchymal stem cells in the repair of tissue injuries].
abstract: Mesenchymal stem cells, which reside in adult bone marrow are multipotent, have an excellent regeneration potential for tissue repair. These cells are able to differentiate in cell culture not only into mesodermal lineages but also into other lineages of ectodermal and endodermal cells. This regenerative process is assisted by application of bioactive molecules, specific growth factors and biomaterials (scaffolds). The cell therapy is successfully used in the treatment of bone defects, nonunions, osteoblasts formed from the mesenchymal stem cells. At present, there are encouraging data in the clinical practice. The mesenchymal stem cell seems to be successful in the regeneration of articular cartilage. There are further promising data for the application of mesenchymal stem cells in the treatment of myocardial infarction, neurologic diseases, liver and kidney diseases and injuries and diabetes mellitus. The aim of this review is to survey the molecular characteristics of mesenchymal stem cells and specific growth factors using the data of preclinical investigations and to call attention to their possible clinical application.
authors.affiliation: Egyetemi Oktatókórház Nonprofit Zrt. Baleseti Sebészeti Osztály, Szombathely. salamon.antal@chello.hu
authors.forename: Antal
authors.initials: A
authors.lastname: Salamon
authors.forename: Erzsébet
authors.initials: E
authors.lastname: Toldy
authors.forename: Lajos
authors.initials: L
authors.lastname: Nagy
authors.forename: Zoltán
authors.initials: Z
authors.lastname: Lőcsei
mesh_terms: D000328:Adult; D001847:Bone Diseases / Q000601:surgery; D001853:Bone Marrow; D001861:Bone Regeneration; D009202:Cardiomyopathies / Q000601:surgery; D002358:Cartilage, Articular / Q000601:surgery; D002454:Cell Differentiation; D002493:Central Nervous System Diseases / Q000601:surgery; D020219:Chondrogenesis; D003920:Diabetes Mellitus / Q000601:surgery; D006801:Humans; D007674:Kidney Diseases / Q000601:surgery; D008107:Liver Diseases / Q000601:surgery; D008115:Liver Regeneration; D045164:Mesenchymal Stem Cell Transplantation / Q000009:adverse effects; D059630:Mesenchymal Stem Cells; D009416:Nerve Regeneration