title: Prospective analysis of vitamin D and endometrial cancer risk.
abstract: BACKGROUND
  This is the first prospective cohort analysis on the association between vitamin D and endometrial cancer incorporating time-varying predicted plasma 25-hydroxyvitamin D [25(OH)D].
  
  
  METHODS
  The prospective cohort analysis of predicted 25(OH)D and total dietary vitamin D intake used the Cox proportional hazards model, and involved 644 incident endometrial cancer events from 1986 to 2006 in the Nurses' Health Study. Genotyping and unconditional logistic regression were carried out on 572 endometrial cancer cases and their matched controls on 12 single nucleotide polymorphisms (SNPs) in vitamin D-related genes.
  
  
  RESULTS
  There was no significant association between predicted 25(OH)D and endometrial cancer incidence, with the hazard ratio for the highest (versus the lowest) quintile of predicted 25(OH)D as 1.00 (95% CI 0.73-1.36) (p-trend = 0.33). There was also no significant association involving total dietary vitamin D. No significant associations between any of the vitamin D-related SNPs and endometrial cancer were observed.
  
  
  CONCLUSIONS
  Both predicted 25(OH)D and total dietary vitamin D intake were not associated with endometrial cancer incidence. These results suggest that vitamin D may not protect against the development of endometrial cancer. However, the low and narrow vitamin D exposure range in the cohort may limit generalizability of the results.
authors.affiliation: Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA. jasonjliu.jjl@gmail.com
authors.forename: J J
authors.initials: JJ
authors.lastname: Liu
authors.forename: K A
authors.initials: KA
authors.lastname: Bertrand
authors.forename: S
authors.initials: S
authors.lastname: Karageorgi
authors.forename: E
authors.initials: E
authors.lastname: Giovannucci
authors.forename: S E
authors.initials: SE
authors.lastname: Hankinson
authors.forename: B
authors.initials: B
authors.lastname: Rosner
authors.forename: L
authors.initials: L
authors.lastname: Maxwell
authors.forename: G
authors.initials: G
authors.lastname: Rodriguez
authors.forename: I
authors.initials: I
authors.lastname: De Vivo
mesh_terms: D000230:Adenocarcinoma / Q000453:epidemiology* / Q000209:etiology / Q000235:genetics; D000328:Adult; D016022:Case-Control Studies; D016889:Endometrial Neoplasms / Q000453:epidemiology* / Q000209:etiology / Q000235:genetics; D005260:Female; D056726:Genetic Association Studies; D006801:Humans; D015994:Incidence; D008875:Middle Aged; D009726:Nurses; D020641:Polymorphism, Single Nucleotide; D016016:Proportional Hazards Models; D011446:Prospective Studies; D012307:Risk Factors; D014807:Vitamin D / Q000031:analogs & derivatives* / Q000097:blood
chemical_list: D014807:Vitamin D; C104450:25-hydroxyvitamin D