title: Pediatric cefepime neurotoxicity.
abstract: Cefepime toxicity is characterized by altered mental status, confusion, and decreased responsiveness. We describe a 14-year-old girl who developed acute encephalopathy associated with supratherapeutic cefepime concentrations in the setting of acute renal failure. The authors were unable to identify any previous reports of this occurrence in a child.
authors.affiliation: Department of Pharmacy, St. Vincent Hospital, Indianapolis, Indiana, USA.
authors.forename: Lindsay C
authors.initials: LC
authors.lastname: Landgrave
authors.forename: John L
authors.initials: JL
authors.lastname: Lock
authors.forename: J Maria
authors.initials: JM
authors.lastname: Whitmore
authors.forename: Christopher E
authors.initials: CE
authors.lastname: Belcher
mesh_terms: D058186:Acute Kidney Injury / Q000139:chemically induced*; D000293:Adolescent; D000900:Anti-Bacterial Agents / Q000009:adverse effects*; D000077723:Cefepime; D002511:Cephalosporins / Q000009:adverse effects*; D005260:Female; D006801:Humans; D020258:Neurotoxicity Syndromes / Q000175:diagnosis*
chemical_list: D000900:Anti-Bacterial Agents; D002511:Cephalosporins; D000077723:Cefepime