title: Proxy-reported questionnaires for young children with asthma: a structured review.
abstract: Which proxy-reported outcome measures have been developed for use with children aged 6 years and younger to assess asthma symptoms, asthma control, and asthma-specific health-related quality of life, and do these questionnaires' measurement properties support their use as end-points in clinical trials? A two-phase literature search was conducted: 1) studies describing relevant questionnaires were identified, and the questionnaires were assessed against predefined criteria; 2) studies providing information on the measurement properties of questionnaires meeting the predefined inclusion criteria were identified. Literature sources included PubMed and EMBASE databases, scientific conference proceedings, a clinical trial registry, and a quality of life instrument database. The initial search of literature databases and conference abstracts identified 631 records. 20 paediatric asthma proxy-reported outcome instruments were identified; seven met the inclusion criteria: Childhood Asthma Control Test, Control de Asma en Niños Questionnaire, Pediatric Asthma Caregiver Diary, Pediatric Asthma Control Tool, PedsQL 3.0 Short-Form 22 Asthma Module, PedsQL Asthma Symptoms Scale, and Test for Respiratory and Asthma Control in Kids. Three proxy-reported outcome instruments were considered suitable for use as end-points in paediatric asthma clinical trials; the Pediatric Asthma Caregiver Diary possesses the strongest measurement properties of the three.
authors.affiliation: RTI Health Solutions, Manchester, UK. abarrett@rti.org
authors.forename: Amy
authors.initials: A
authors.lastname: Barrett
authors.forename: Marci
authors.initials: M
authors.lastname: Clark
authors.forename: Carla
authors.initials: C
authors.lastname: Demuro
authors.forename: Dirk
authors.initials: D
authors.lastname: Esser
mesh_terms: D001249:Asthma / Q000175:diagnosis* / Q000628:therapy; D017028:Caregivers; D002648:Child; D002675:Child, Preschool; D002986:Clinical Trials as Topic; D006801:Humans; D010290:Parents; D019727:Proxy; D011594:Psychometrics / Q000379:methods; D011788:Quality of Life; D015203:Reproducibility of Results; D012107:Research Design; D011795:Surveys and Questionnaires; D063189:Symptom Assessment / Q000379:methods*; D016896:Treatment Outcome