title: Diet enriched with korean pine nut oil improves mitochondrial oxidative metabolism in skeletal muscle and brown adipose tissue in diet-induced obesity.
abstract: In this study, we investigated effects of pine nut oil (PNO) on high-fat-diet (HFD)-induced obesity and metabolic dysfunction in skeletal muscle and brown adipose tissue (BAT). Male C57BL/6 mice were fed a HFD with 15% energy from lard and 30% energy from either soybean oil (SBO-HFD) or PNO (PNO-HFD) for 12 weeks. The PNO-HFD resulted in less weight gain and intramuscular lipid accumulation than the SBO-HFD and was accompanied by upregulation of transcripts and proteins related to oxidative metabolism and phosphorylation of AMP-activated protein kinase (AMPK), as well as molecules selectively expressed in type I and type IIa muscle fibers. In addition, uncoupling protein-1 was upregulated in BAT. These beneficial metabolic effects were partly associated with the dual ligand activity of pinolenic acid, which is abundant in PNO, for peroxisome proliferator-activated receptors α and δ. Our findings suggest that PNO may have potential as a dietary supplement for counteracting obesity and metabolic dysregulation.
authors.affiliation: Department of Food Science and Nutrition, University of Ulsan, Ulsan 680-749, South Korea.
authors.forename: Ngoc Hoan
authors.initials: NH
authors.lastname: Le
authors.forename: Sunhye
authors.initials: S
authors.lastname: Shin
authors.forename: Thai Hien
authors.initials: TH
authors.lastname: Tu
authors.forename: Chu-Sook
authors.initials: CS
authors.lastname: Kim
authors.forename: Ji-Hye
authors.initials: JH
authors.lastname: Kang
authors.forename: Goto
authors.initials: G
authors.lastname: Tsuyoshi
authors.forename: Kawada
authors.initials: K
authors.lastname: Teruo
authors.forename: Sung Nim
authors.initials: SN
authors.lastname: Han
authors.forename: Rina
authors.initials: R
authors.lastname: Yu
mesh_terms: D055372:AMP-Activated Protein Kinases / Q000378:metabolism; D002001:Adipose Tissue, Brown / Q000187:drug effects / Q000378:metabolism*; D000818:Animals; D004032:Diet; D059305:Diet, High-Fat / Q000009:adverse effects; D004041:Dietary Fats / Q000494:pharmacology; D007473:Ion Channels / Q000378:metabolism; D008042:Linolenic Acids / Q000494:pharmacology; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008928:Mitochondria / Q000187:drug effects / Q000378:metabolism*; D024101:Mitochondrial Proteins / Q000378:metabolism; D018482:Muscle, Skeletal / Q000187:drug effects / Q000378:metabolism*; D009754:Nuts / Q000737:chemistry; D009765:Obesity / Q000139:chemically induced / Q000178:diet therapy / Q000378:metabolism*; D047493:PPAR alpha / Q000378:metabolism; D047494:PPAR delta / Q000378:metabolism; D010766:Phosphorylation / Q000187:drug effects; D028223:Pinus / Q000737:chemistry*; D010938:Plant Oils / Q000494:pharmacology*; D013024:Soybean Oil / Q000494:pharmacology; D022722:Thermogenesis / Q000187:drug effects; D000071256:Uncoupling Protein 1; D015430:Weight Gain / Q000187:drug effects
chemical_list: D004041:Dietary Fats; D007473:Ion Channels; D008042:Linolenic Acids; D024101:Mitochondrial Proteins; D047493:PPAR alpha; D047494:PPAR delta; D010938:Plant Oils; C000604372:Ucp1 protein, mouse; D000071256:Uncoupling Protein 1; C034302:5,9,12-octadecatrienoic acid; D013024:Soybean Oil; D055372:AMP-Activated Protein Kinases; C029310:lard