title: Strain-specific induction of experimental autoimmune prostatitis (EAP) in mice.
abstract: BACKGROUND
  Prostatitis, a clinical syndrome characterized by pelvic pain and inflammation, is common in adult males. Although several induced and spontaneous murine models of prostatitis have been explored, the role of genetic background on induction has not been well-defined.
  
  
  METHODS
  Using a standard methodology for the induction of experimental autoimmune prostatitis (EAP), we investigated both acute and chronic inflammation on several murine genetic backgrounds.
  
  
  RESULTS
  In our colony, nonobese diabetic (NOD) mice evinced spontaneous prostatitis that was not augmented by immunization with rat prostate extract (RPE). In contrast, the standard laboratory strain Balb/c developed chronic inflammation in response to RPE immunization. Development of EAP in other strains was variable.
  
  
  CONCLUSIONS
  These data suggest that Balb/c mice injected with RPE may provide a useful model for chronic prostatic inflammation.
authors.affiliation: Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
authors.forename: Christopher M
authors.initials: CM
authors.lastname: Jackson
authors.forename: Dallas B
authors.initials: DB
authors.lastname: Flies
authors.forename: Claudio A
authors.initials: CA
authors.lastname: Mosse
authors.forename: Anil
authors.initials: A
authors.lastname: Parwani
authors.forename: Edward L
authors.initials: EL
authors.lastname: Hipkiss
authors.forename: Charles G
authors.initials: CG
authors.lastname: Drake
mesh_terms: D000208:Acute Disease; D000818:Animals; D001327:Autoimmune Diseases / Q000235:genetics / Q000276:immunology / Q000473:pathology; D015551:Autoimmunity / Q000235:genetics* / Q000276:immunology; D002457:Cell Extracts / Q000276:immunology / Q000494:pharmacology; D002908:Chronic Disease; D004195:Disease Models, Animal; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D019463:Mice, Inbred MRL lpr; D016688:Mice, Inbred NOD; D008814:Mice, Inbred NZB; D011467:Prostate / Q000276:immunology / Q000473:pathology; D011472:Prostatitis / Q000235:genetics / Q000276:immunology / Q000473:pathology; D051381:Rats; D017208:Rats, Wistar; D013045:Species Specificity
chemical_list: D002457:Cell Extracts