title: Two faces of brd4: mitotic bookmark and transcriptional lynchpin.
abstract: The bromodomain protein BRD4 links cell cycle and transcription, bookmarking active genes during mitosis and serving as a scaffold for transcription factors. Our recent discovery that BRD4 is a RNA Polymerase II CTD kinase identifies a novel transcriptional function. Here we discuss our model in the context of current knowledge.
authors.affiliation: Experimental Immunology Branch, National Cancer Institute, NIH, Bethesda, MD, USA.
authors.forename: Ballachanda N
authors.initials: BN
authors.lastname: Devaiah
authors.forename: Dinah S
authors.initials: DS
authors.lastname: Singer
mesh_terms: D000818:Animals; D018797:Cell Cycle Proteins; D006801:Humans; D008938:Mitosis; D008954:Models, Biological; D009687:Nuclear Proteins; D014157:Transcription Factors / Q000378:metabolism*; D014158:Transcription, Genetic; D000092468:Bromodomain Containing Proteins
chemical_list: D018797:Cell Cycle Proteins; D009687:Nuclear Proteins; D014157:Transcription Factors; C441289:BRD4 protein, human; D000092468:Bromodomain Containing Proteins
keywords: Atypical kinase; BET protein; BRD4; CTD kinase; P-TEFb; RNA Polymerase II