title: Oestrogen alpha-receptor variant and two-year memory decline in midlife Australian women.
abstract: OBJECTIVE
  To prospectively examine the influence of the oestrogen-α receptor (ESR1)PvuII polymorphism on changes in memory performance over a 2-year period among 80 midlife postmenopausal Australian women.
  
  
  METHODS
  Healthy women aged 56-67 years were administered a battery of four memory (verbal and non-verbal) tasks at baseline and 2 years later.
  
  
  RESULTS
  Carriers of the ESR1 p allele had significantly greater declines in logical memory compared to participants with the PP genotype, independent of demographic characteristics (e.g. age), chronic illness (e.g. hypertension), sleep aid usage, hormone levels, apolipoprotein E e4 status and prospective changes in mood, smoking and alcohol consumption.
  
  
  CONCLUSIONS
  These findings provide preliminary evidence for larger and longer prospective trials that will be able to determine if the p allele of the ESR1PvuII polymorphism is a potential biomarker of logical memory decline among aging women.
authors.affiliation: Department of Psychiatry, The University of Melbourne, Melbourne, Vic., Australia. cbousman@unimelb.edu.au
authors.forename: Chad A
authors.initials: CA
authors.lastname: Bousman
authors.forename: Cassandra
authors.initials: C
authors.lastname: Szoeke
authors.forename: Karren
authors.initials: K
authors.lastname: Chen
authors.forename: Lorraine
authors.initials: L
authors.lastname: Dennerstein
authors.forename: Victor W
authors.initials: VW
authors.lastname: Henderson
authors.forename: Ian P
authors.initials: IP
authors.lastname: Everall
mesh_terms: D000375:Aging / Q000235:genetics*; D000483:Alleles; D001057:Apolipoproteins E / Q000235:genetics; D001315:Australia; D047628:Estrogen Receptor alpha / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D008569:Memory Disorders / Q000235:genetics*; D008875:Middle Aged; D009483:Neuropsychological Tests; D011110:Polymorphism, Genetic / Q000235:genetics*; D012307:Risk Factors
chemical_list: D001057:Apolipoproteins E; D047628:Estrogen Receptor alpha