title: A direct surface modification of iron oxide nanoparticles with various poly(amino acid)s for use as magnetic resonance probes.
abstract: Water soluble and biocompatible iron oxide nanoparticles coated with poly(aspartic acid) (PAsp), poly(asparagines) (PAsn), poly(2-hydroxy-ethyl L-aspartamide) (PHEA), and poly-α,β-(N-2-dimethylaminoethyl L-aspartamide) (PDMAEA) were prepared by hydrophobic interaction between hydrophobic iron oxide nanoparticles and each amphiphilic poly(amino acid)s graft polymer. The octadecyl side chain grafted poly(succinimide)(PSI-g-C(18)), used as a precursor polymer, was easily aminolyzed with nucleophilic compounds to form various poly(amino acid)s graft polymer (PAsp-g-C(18), PAsn-g-C(18), PHEA-g-C(18), PDMAEA-g-C(18),) and simultaneously stabilize the dispersion of iron oxide nanoparticles in aqueous solution. The diameters of the poly(amino acid)s coated iron oxide nanoparticles (PAIONs) were smaller than 30 nm in aqueous solution, extremely stable in aqueous solutions with a wide range of pH and salt concentrations. Further, all the PAIONs showed excellent MR signal intensities (high r(2) values) and the cellular uptake property of the PAIONs was also evaluated.
authors.affiliation: Decontamination & Decommissioning Research Division, Korea Atomic Energy Research Institute, Daejeon 305-353, Republic of Korea.
authors.forename: Hee-Man
authors.initials: HM
authors.lastname: Yang
authors.forename: Chan Woo
authors.initials: CW
authors.lastname: Park
authors.forename: Taebin
authors.initials: T
authors.lastname: Ahn
authors.forename: Bokyung
authors.initials: B
authors.lastname: Jung
authors.forename: Bum-Kyoung
authors.initials: BK
authors.lastname: Seo
authors.forename: Jung-Hwan
authors.initials: JH
authors.lastname: Park
authors.forename: Jong-Duk
authors.initials: JD
authors.lastname: Kim
mesh_terms: D002470:Cell Survival; D005290:Ferric Compounds / Q000737:chemistry* / Q000494:pharmacology; D006801:Humans; D007624:KB Cells; D008279:Magnetic Resonance Imaging / Q000379:methods; D009682:Magnetic Resonance Spectroscopy / Q000379:methods; D053758:Nanoparticles / Q000737:chemistry* / Q000648:ultrastructure; D010455:Peptides / Q000737:chemistry* / Q000494:pharmacology; D019047:Phantoms, Imaging; D017550:Spectroscopy, Fourier Transform Infrared; D013499:Surface Properties
chemical_list: D005290:Ferric Compounds; D010455:Peptides; C008965:alpha,beta-poly((2-hydroxyethyl)-aspartamide); C000499:ferric oxide; C017645:polyaspartate; C045164:polyasparagine