title: Two new hemiterpene glycosides from the leaves of Ilex rotunda. Thunb.
abstract: Chromatographic separation of the 80% MeOH extract of the leaves of Ilex rotunda (IR) led to isolation of two new hemiterpene glycosides, tentatively named as rotundarpenoside A (1) and rotundarpenoside B (2), along with five known caffeoyl derivatives (3-7). The chemical structures of these compounds were elucidated using 1D/2D NMR, HR-MS, and the absolute configuration was confirmed by Mosher's method. In order to evaluate their anti-oxidative activities, 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging activity and xanthine oxidase superoxide scavenging activities (NBT) were determined.
authors.affiliation: Department of Pharmacognosy, College of Pharmacy, Chung-Ang University, Seoul, Republic of Korea.
authors.forename: Manh Heun
authors.initials: MH
authors.lastname: Kim
authors.forename: Kwan Hee
authors.initials: KH
authors.lastname: Park
authors.forename: Myeong Hwan
authors.initials: MH
authors.lastname: Oh
authors.forename: Han Hyuk
authors.initials: HH
authors.lastname: Kim
authors.forename: Kang In
authors.initials: KI
authors.lastname: Choe
authors.forename: Sang Hee
authors.initials: SH
authors.lastname: Park
authors.forename: Min Won
authors.initials: MW
authors.lastname: Lee
mesh_terms: D001713:Biphenyl Compounds / Q000737:chemistry; D016166:Free Radical Scavengers / Q000302:isolation & purification* / Q000494:pharmacology; D006027:Glycosides / Q000302:isolation & purification* / Q000494:pharmacology; D045782:Hemiterpenes / Q000302:isolation & purification* / Q000494:pharmacology; D030017:Ilex / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D010851:Picrates / Q000737:chemistry; D018515:Plant Leaves / Q000737:chemistry; D013481:Superoxides / Q000737:chemistry; D014969:Xanthine Oxidase / Q000737:chemistry
chemical_list: D001713:Biphenyl Compounds; D016166:Free Radical Scavengers; D006027:Glycosides; D045782:Hemiterpenes; D010851:Picrates; D013481:Superoxides; C004931:1,1-diphenyl-2-picrylhydrazyl; D014969:Xanthine Oxidase