title: Relationships between serum uric acid, adiponectin and arterial stiffness in postmenopausal women.
abstract: OBJECTIVE
  Cardiovascular disease (CVD) is a leading cause of death in postmenopausal women. Elevated serum uric acid levels, hypoadiponectinemia and arterial stiffness are strongly associated with cardiovascular diseases. We investigated the relationships among uric acid, adiponectin and arterial stiffness in postmenopausal women.
  
  
  METHODS
  9555 subjects who had the routine health check-ups, 841 postmenopausal women aged 50 years or older who had not had a menstrual period for more than 12 consecutive months were included in this study.
  
  
  METHODS
  BMI, WC, and serum concentrations of uric acid, adiponectin, glucose, lipids (total cholesterol, triglycerides, LDL cholesterol, and HDL cholesterol) were measured. Insulin resistance was estimated by the insulin resistance index of homeostasis model assessment (HOMA-IR). Pulse wave velocity (PWV) was evaluated to assess arterial stiffness.
  
  
  RESULTS
  The subjects were stratified into three groups according to uric acid values. PWV values gradually increased and adiponectin level decreased with uric acid tertiles. Serum uric acid levels in postmenopausal women correlated significantly with age, BMI, WC, TG, HDL-C, insulin, HOMA-IR, adiponectin and PWV. Multiple regression analysis showed that WC (β=0.141, P<0.01), HOMA (β=0.137, P<0.01), adiponectin (β=-0.104, P<0.01), and PWV (β=0.129, P<0.01) were independently correlated with uric acid levels. In multiple logistic regression analysis after adjusting for risk factors, uric acid was a significant contributor to increased PWV.
  
  
  CONCLUSIONS
  These findings indicate that serum uric acid is independently associated with adiponectin and arterial stiffness in postmenopausal women.
authors.affiliation: Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Republic of Korea.
authors.forename: Jong Suk
authors.initials: JS
authors.lastname: Park
authors.forename: Shinae
authors.initials: S
authors.lastname: Kang
authors.forename: Chul Woo
authors.initials: CW
authors.lastname: Ahn
authors.forename: Bong Soo
authors.initials: BS
authors.lastname: Cha
authors.forename: Kyung Rae
authors.initials: KR
authors.lastname: Kim
authors.forename: Hyun Chul
authors.initials: HC
authors.lastname: Lee
mesh_terms: D052242:Adiponectin / Q000097:blood*; D001786:Blood Glucose / Q000378:metabolism; D015992:Body Mass Index; D002318:Cardiovascular Diseases / Q000097:blood*; D002784:Cholesterol / Q000097:blood; D005260:Female; D006801:Humans; D007333:Insulin Resistance; D008875:Middle Aged; D015999:Multivariate Analysis; D017698:Postmenopause; D063177:Pulse Wave Analysis; D012044:Regression Analysis; D014280:Triglycerides / Q000097:blood; D014527:Uric Acid / Q000097:blood*; D059289:Vascular Stiffness / Q000502:physiology*; D055105:Waist Circumference / Q000502:physiology
chemical_list: D052242:Adiponectin; D001786:Blood Glucose; D014280:Triglycerides; D014527:Uric Acid; D002784:Cholesterol