title: Cytogenetics and molecular cytogenetics in diffuse large B-cell lymphoma (DLBCL).
abstract: BACKGROUND
  Diffuse large B-cell lymphoma (DLBCL) accounts for up to 40% of all non-Hodgkin's lymphomas diagnosed in the western hemisphere. Determination of the gene expression profile has confirmed the physiological heterogeneity of the disease and defined three molecular prognostic subgroups - germinal center B-cell-like (GCB), activated B-cell-like (ABC) and primary mediastinal B-cell lymphoma (PMBL) - with different gene expression and prognosis.
  
  
  RESULTS
  This review covers current knowledge on the most frequent recurrent cytogenetic and molecular cytogenetic aberrations in molecular DLBCL subgroups.
  
  
  CONCLUSIONS
  Cytogenetic and molecular cytogenetic techniques used to determine nonrandom chromosomal aberrations in patients with DLBCL have revealed the incidence of frequent cytogenetic aberrations in the subgroups reported, suggesting their potential use for more accurate prognostic stratification of DLBCL, contributing to personalized selection of the most effective therapy.
authors.affiliation: Department of Hemato-Oncology, Faculty of Medicine and Dentistry, Palacky University Olomouc, Czech Republic.
authors.forename: Radka
authors.initials: R
authors.lastname: Nedomova
authors.forename: Tomas
authors.initials: T
authors.lastname: Papajik
authors.forename: Vit
authors.initials: V
authors.lastname: Prochazka
authors.forename: Karel
authors.initials: K
authors.lastname: Indrak
authors.forename: Marie
authors.initials: M
authors.lastname: Jarosova
mesh_terms: D000328:Adult; D002471:Cell Transformation, Neoplastic / Q000235:genetics; D002869:Chromosome Aberrations; D005260:Female; D020869:Gene Expression Profiling; D019254:Genes, bcl-2 / Q000235:genetics; D006801:Humans; D016403:Lymphoma, Large B-Cell, Diffuse / Q000145:classification / Q000235:genetics*; D008297:Male; D008479:Mediastinal Neoplasms / Q000235:genetics; D011379:Prognosis; D051560:Proto-Oncogene Proteins c-bcl-6 / Q000235:genetics
chemical_list: D051560:Proto-Oncogene Proteins c-bcl-6