title: Pulmonary thrombosis associated with antidiuretic hormone replacement therapy due to secondary diabetes insipidus after traumatic brain injury: A case report.
abstract: BACKGROUND
  Diabetes insipidus is a well-recognized complication of traumatic brain injury. The majority of patients with post-traumatic diabetes insipidus will require antidiuretic hormone (ADH) replacement therapy and tend to show dehydration. On the other hand, some negative effects of ADH on blood coagulation, such as increased platelet cohesion and the promotion of von Willebrand factor release, have also been reported. However, the incidence of thrombosis during antidiuretic hormone replacement therapy is disputed.
  
  
  METHODS
  A case of pulmonary thrombosis associated with ADH replacement therapy due to secondary diabetes insipidus after traumatic brain injury is presented here.
  
  
  CONCLUSIONS
  In our case, there were three factors that may have contributed to the observed thrombosis (dehydration, bed rest for a long period and ADH replacement therapy).
  
  
  CONCLUSIONS
  We believe that controlling urinary output and monitoring urinary and serum osmotic pressure are necessary for the management for diabetes insipidus patients after traumatic brain injury. In particular, we must carefully monitor the management of such patients during antidiuretic hormone replacement therapy.
authors.affiliation: Department of Orthopaedic Surgery, Juntendo University Shizuoka Hospital, 1129 Nagaoka, Izunokuni, Shizuoka 410-2295, Japan. Electronic address: knaito@juntendo.ac.jp.
authors.forename: Kiyohito
authors.initials: K
authors.lastname: Naito
authors.forename: Taiji
authors.initials: T
authors.lastname: Watari
authors.forename: Eisuke
authors.initials: E
authors.lastname: Yasunari
authors.forename: Miki
authors.initials: M
authors.lastname: Yamano
authors.forename: Atsuhiko
authors.initials: A
authors.lastname: Mogami
authors.forename: Osamu
authors.initials: O
authors.lastname: Obayashi
authors.forename: Kazuo
authors.initials: K
authors.lastname: Kaneko