title: [Expression of the activating receptor NKG2D on peripheral blood mononuclear cells in patient with oral squamous cell carcinoma and its clinical significance].
abstract: OBJECTIVE
  To investigate the expression of activating receptor NKG2D(natural killer group 2,member D) on peripheral blood mononuclear cells(PBMCs) in patients with oral squamous cell carcinoma(OSCC) and its clinicopathological significance.
  
  
  METHODS
  The expression of NKG2D on PBMCs in 54 OSCC patients and 20 healthy controls were assessed by flow cytometry. The data was analyzed with SPSS16.0 software package for independent-sample t test and one-way ANOVA test.
  
  
  RESULTS
  The positive rate of assay for NKG2D on PBMCs in OSCC patients (12.49±5.26)% was lower than that of the controls (22.93±8.14)% (P<0.05). And which was significantly different among different clinicopathological parameters such as tumor size and disease stage(P<0.05), but no significant difference was found among different gender, age, tumor location, tumor differentiation and cervical lymph node status (P>0.05).
  
  
  CONCLUSIONS
  The NKG2D expression on PBMCs in OSCC patients was lower than that of healthy controls and was correlated with tumor size and disease stage.
authors.affiliation: Department of Oral and Maxillofacial Surgery, Xiangya Hospital, Changsha 410008, Hunan Province, China. duduniao7201985@yahoo.com.cn
authors.forename: Chao
authors.initials: C
authors.lastname: Li
authors.forename: Fang-qiong
authors.initials: FQ
authors.lastname: Shi
authors.forename: Dan
authors.initials: D
authors.lastname: Yang
authors.forename: Jie
authors.initials: J
authors.lastname: Wang
authors.forename: Xin-chun
authors.initials: XC
authors.lastname: Jian
authors.forename: Can-hua
authors.initials: CH
authors.lastname: Jiang
mesh_terms: D002294:Carcinoma, Squamous Cell; D006801:Humans; D007963:Leukocytes, Mononuclear; D009062:Mouth Neoplasms; D055655:NK Cell Lectin-Like Receptor Subfamily K
chemical_list: C527085:KLRK1 protein, human; D055655:NK Cell Lectin-Like Receptor Subfamily K