title: Association of carcinoid tumor and low grade glioma.
abstract: BACKGROUND
  Lung carcinoid tumor and low grade glioma are two uncommon malignancies.
  
  
  METHODS
  We report the case of 24-year-old man who presented with respiratory disease. Imaging investigations showed a right lung tumor and histological analysis confirmed a typical carcinoid tumor. As part of initial staging, brain MRI revealed an asymptomatic right frontal lesion. First, a right pulmonary lobectomy was performed without adjuvant treatment. In second time, brain tumorectomy was performed. Histological examination confirmed the diagnosis of low grade glioma (LGG). The patient remained in complete remission 2.5 years after the initial diagnosis.
  
  
  RESULTS
  This is the first case reporting the association between LGG and lung carcinoid tumor, while no association between LGG and a systemic tumor have been published to date. Association of lung carcinoid tumor with other malignant diseases has been reported but remained uncommon. Only minimal data support a potential molecular common origin.
  
  
  CONCLUSIONS
  This exceptional association may be fortuitous. However, their concomitant diagnoses suggest a potential association between both rare diseases. A genetic susceptibility remains possible.
authors.affiliation: Département d'Oncologie Médicale, Institut Paoli-Calmettes, 232 Boulevard Ste Marguerite, 13009 Marseille, France. emeline.tabouret@gmail.com
authors.forename: Emeline
authors.initials: E
authors.lastname: Tabouret
authors.forename: Maryline
authors.initials: M
authors.lastname: Barrié
authors.forename: Cecile
authors.initials: C
authors.lastname: Vicier
authors.forename: Anthony
authors.initials: A
authors.lastname: Gonçalves
authors.forename: Olivier
authors.initials: O
authors.lastname: Chinot
authors.forename: Patrice
authors.initials: P
authors.lastname: Viens
authors.forename: Anne
authors.initials: A
authors.lastname: Madroszyk
mesh_terms: D000328:Adult; D001932:Brain Neoplasms / Q000175:diagnosis / Q000601:surgery*; D002276:Carcinoid Tumor / Q000175:diagnosis / Q000601:surgery*; D005910:Glioma / Q000175:diagnosis / Q000601:surgery*; D006801:Humans; D008175:Lung Neoplasms / Q000175:diagnosis / Q000601:surgery*; D008297:Male; D060787:Neoplasm Grading