title: Epigenetic implication of gene-adjacent retroelements in Helicobacter pylori-infected adults.
abstract: A chronic inflammatory condition of gastric mucosa can facilitate the influx of new stem cells into the stomach. Epigenetic codes, such as DNA methylation, may be responsible for the stable maintenance of epigenetic phenotypes established in the new stomach-adapted stem cells. A number of hypotheses have been made for the role of CpG-island methylation, which is common in the Helicobacter pylori-infected stomach. However, they could not explain the plausible role of CpG-island methylation in the re-establishment of epigenetic phenotypes. These islands are highly repetitive sequences densely methylated throughout the human genome, the so-called parasitic retroelements, which expand a number of cDNA copies with reverse transcriptase. The densely methylated retroelements adjacent to the host genes can form the transitional-CpG sites around gene-control regions that are barely methylated. This review focuses on the putative role of transitional CpG methylation in the adaptive differentiation of new stem cells in the H. pylori-infected stomach.
authors.affiliation: Department of Microbiology, College of Medicine, The Catholic University of Korea, 505 Banpo-dong Socho-gu, Seoul 137-701, Korea.
authors.forename: Mun-Gan
authors.initials: MG
authors.lastname: Rhyu
authors.forename: Jung-Hwan
authors.initials: JH
authors.lastname: Oh
authors.forename: Seung-Jin
authors.initials: SJ
authors.lastname: Hong
mesh_terms: D020087:Alu Elements; D000818:Animals; D018899:CpG Islands; D019175:DNA Methylation; D044127:Epigenesis, Genetic; D015972:Gene Expression Regulation, Neoplastic; D015894:Genome, Human; D016481:Helicobacter Infections; D016480:Helicobacter pylori / Q000235:genetics* / Q000472:pathogenicity; D006801:Humans; D007413:Intestinal Mucosa / Q000382:microbiology / Q000473:pathology; D013234:Stem Cells / Q000473:pathology; D013270:Stomach / Q000382:microbiology; D013274:Stomach Neoplasms / Q000382:microbiology / Q000473:pathology