title: Tissue proteomics in pancreatic cancer study: discovery, emerging technologies, and challenges.
abstract: Pancreatic cancer is a highly lethal disease that is difficult to diagnose and treat. The advances in proteomics technology, especially quantitative proteomics, have stimulated a great interest in applying this technology for pancreatic cancer study. A variety of tissue proteomics approaches have been applied to investigate pancreatic cancer and the associated diseases. These studies were carried out with various goals, aiming to better understand the molecular mechanisms underlying pancreatic tumorigenesis, to improve therapeutic treatment and to identify cancer associated protein signatures, signaling events as well as interactions between cancer cells and tumor microenvironment. Here, we provide an overview on the tissue proteomics studies of pancreatic cancer reported in the past few years in light of discovery and technology development.
authors.affiliation: Department of Medicine, University of Washington, Seattle, WA 98195, USA. shengp@medicine.washington.edu
authors.forename: Sheng
authors.initials: S
authors.lastname: Pan
authors.forename: Teresa A
authors.initials: TA
authors.lastname: Brentnall
authors.forename: Kimberly
authors.initials: K
authors.lastname: Kelly
authors.forename: Ru
authors.initials: R
authors.lastname: Chen
mesh_terms: D000818:Animals; D045744:Cell Line, Tumor; D006801:Humans; D013058:Mass Spectrometry; D014411:Neoplastic Stem Cells / Q000378:metabolism / Q000473:pathology; D010190:Pancreatic Neoplasms / Q000378:metabolism* / Q000473:pathology; D020543:Proteome / Q000302:isolation & purification / Q000378:metabolism*; D040901:Proteomics; D015398:Signal Transduction; D016707:Tissue Fixation
chemical_list: D020543:Proteome