title: Complete genome sequence of the novel Escherichia coli phage phAPEC8.
abstract: Bacteriophage phAPEC8 is an Escherichia coli-infecting myovirus, isolated on an avian pathogenic Escherichia coli (APEC) strain. APEC strains cause colibacillosis in poultry, resulting in high mortality levels and important economic losses. Genomic analysis of the 147,737-bp double-stranded DNA phAPEC8 genome revealed that 53% of the 269 encoded proteins are unique to this phage. Its closest relatives include the Salmonella phage PVP-SE1 and the coliphage rv5, with 19% and 18% similar proteins, respectively. As such, phAPEC8 represents a novel, phylogenetically distinct clade within the Myoviridae, with molecular properties suitable for phage therapy applications.
authors.affiliation: Division of Gene Technology, KU Leuven, Leuven, Belgium.
authors.forename: J
authors.initials: J
authors.lastname: Tsonos
authors.forename: E M
authors.initials: EM
authors.lastname: Adriaenssens
authors.forename: J
authors.initials: J
authors.lastname: Klumpp
authors.forename: J-P
authors.initials: JP
authors.lastname: Hernalsteens
authors.forename: R
authors.initials: R
authors.lastname: Lavigne
authors.forename: H
authors.initials: H
authors.lastname: De Greve
mesh_terms: D020816:Amino Acid Motifs; D001483:Base Sequence; D001530:Belgium; D003090:Coliphages / Q000145:classification / Q000235:genetics*; D004926:Escherichia coli / Q000821:virology*; D016679:Genome, Viral / Q000235:genetics*; D008969:Molecular Sequence Data; D017900:Myoviridae / Q000145:classification / Q000235:genetics*; D010802:Phylogeny; D017422:Sequence Analysis, DNA; D017385:Sequence Homology; D013045:Species Specificity