title: [New treatment strategies for male lower urinary tract symptoms].
abstract: For patients with lower urinary tract symptoms (LUTS), α1-adrenoreceptor inhibitors and 5-alpha reductase inhibitors as well as their combination are considered the gold standard. In addition, anticholinergic agents are being introduced as monotherapy or in combination with α1-adrenocepetor inhibitors for patients with predominant storage disorders. Phosphodiesterase 5 (PDE5) inhibitors are often the best option for patients with LUTS who also suffer from erectile dysfunction. Recently, novel treatment options have been presented and intraprostatic injection of various agents, such as botulinum toxin A, NX-1207 and PRX302 has shown promising initial results. In addition, innovative minimally invasive treatment options, such as UroLift® appear to be efficacious and safe in this patient cohort. Particular emphasis should be laid on patients with LUTS and concomitant sexual disorders.
authors.affiliation: Klinik für Urologie, Universitätsklinikum Tübingen, Hoppe-Seyler-Straße 3, 72076 Tübingen, Deutschland.
authors.forename: L F
authors.initials: LF
authors.lastname: Arenas da Silva
authors.forename: M
authors.initials: M
authors.lastname: Schönthaler
authors.forename: F
authors.initials: F
authors.lastname: Cruz
authors.forename: C
authors.initials: C
authors.lastname: Gratzke
authors.forename: J
authors.initials: J
authors.lastname: Zumbe
authors.forename: A
authors.initials: A
authors.lastname: Stenzl
authors.forename: B
authors.initials: B
authors.lastname: Amend
authors.forename: K-D
authors.initials: KD
authors.lastname: Sievert
mesh_terms: D058891:5-alpha Reductase Inhibitors / Q000627:therapeutic use*; D058668:Adrenergic alpha-1 Receptor Antagonists / Q000627:therapeutic use*; D006801:Humans; D059411:Lower Urinary Tract Symptoms / Q000628:therapy*; D008297:Male; D019060:Minimally Invasive Surgical Procedures / Q000295:instrumentation* / Q000379:methods; D058986:Phosphodiesterase 5 Inhibitors / Q000627:therapeutic use*; D019736:Prostheses and Implants; D013520:Urologic Surgical Procedures / Q000295:instrumentation* / Q000379:methods
chemical_list: D058891:5-alpha Reductase Inhibitors; D058668:Adrenergic alpha-1 Receptor Antagonists; D058986:Phosphodiesterase 5 Inhibitors