title: Cardiac metabolism in hypertrophy and heart failure: implications for therapy.
abstract: The heart consumes huge amounts of energy to fulfil its function as a relentless pump. A highly sophisticated system of energy generation based on flexibility of substrate use and efficient energy production, effective energy sensing and energy transfer ensures function of the healthy heart across a range of physiological situations. In left ventricular hypertrophy and heart failure, these processes become disturbed, leading as will be discussed to impaired cardiac energetic status and to further impairment of cardiac function. These metabolic disturbances form a potential target for therapy.
authors.affiliation: School of Medicine and Dentistry, University of Aberdeen, Polwarth Building, Foresterhill, Aberdeen, AB25 2ZD, UK.
authors.forename: N
authors.initials: N
authors.lastname: Siddiqi
authors.forename: S
authors.initials: S
authors.lastname: Singh
authors.forename: R
authors.initials: R
authors.lastname: Beadle
authors.forename: D
authors.initials: D
authors.lastname: Dawson
authors.forename: M
authors.initials: M
authors.lastname: Frenneaux
mesh_terms: D000818:Animals; D002316:Cardiotonic Agents / Q000627:therapeutic use*; D004734:Energy Metabolism; D006333:Heart Failure / Q000188:drug therapy* / Q000378:metabolism*; D006801:Humans; D017379:Hypertrophy, Left Ventricular / Q000188:drug therapy* / Q000378:metabolism*; D009206:Myocardium / Q000378:metabolism*
chemical_list: D002316:Cardiotonic Agents