title: Oncologic and functional outcomes of partial laryngeal surgery for intermediate-stage laryngeal cancer.
abstract: OBJECTIVE
  To evaluate the oncologic and functional outcomes of partial laryngeal surgery (PLS) using transoral laser microsurgery (TLM) and supracricoid laryngectomy (SCL) in patients with intermediate-stage laryngeal squamous cell carcinoma (LSCC).
  
  
  METHODS
  Historical cohort study.
  
  
  METHODS
  Single tertiary care center.
  
  
  METHODS
  Retrospective review of oncologic and functional outcomes in intermediate-stage (T2-3/N0-1, stage II and III) LSCC patients who underwent TLM or SCL from 1998 to 2010.
  
  
  RESULTS
  Sixty patients were included, of whom 28 (47%) underwent TLM and 32 (53%) underwent SCL. For the entire cohort, 2- and 5-year probabilities were 86.2% (95% confidence interval [CI], 73.0%-93.2%) and 72.9% (95% CI, 52.4%-85.6%), respectively, for overall survival (OS) and 79.3% (95% CI, 65.6%-88.0%) and 62.4% (95% CI, 41.9%-77.4%), respectively, for recurrence-free survival (RFS). There was no difference between the TLM and SCL cohorts in OS (P = .542) or RFS (P = .483). More than 75% of patients avoided adjuvant therapy. Communication Scale and Functional Outcome Swallowing Scale scores at median follow-up of 33 months were 2 or better in 97% and 91% of patients, respectively, reflecting functional voice and swallowing postoperatively. Eighty-eight percent of patients retained a functional larynx.
  
  
  CONCLUSIONS
  PLS provides excellent oncologic and functional outcomes for intermediate-stage LSCC and should be considered an alternative to chemoradiation or total laryngectomy in selected patients.
authors.affiliation: Department of Otolaryngology, University of Minnesota School of Medicine, Minneapolis, Minnesota, USA.
authors.forename: Emiro
authors.initials: E
authors.lastname: Caicedo-Granados
authors.forename: Daniel M
authors.initials: DM
authors.lastname: Beswick
authors.forename: Apostolos
authors.initials: A
authors.lastname: Christopoulos
authors.forename: Diana E
authors.initials: DE
authors.lastname: Cunningham
authors.forename: Ali
authors.initials: A
authors.lastname: Razfar
authors.forename: James P
authors.initials: JP
authors.lastname: Ohr
authors.forename: Dwight E
authors.initials: DE
authors.lastname: Heron
authors.forename: Robert L
authors.initials: RL
authors.lastname: Ferris
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001706:Biopsy; D002294:Carcinoma, Squamous Cell / Q000473:pathology / Q000601:surgery*; D016001:Confidence Intervals; D005260:Female; D006801:Humans; D007822:Laryngeal Neoplasms / Q000473:pathology / Q000601:surgery*; D007825:Laryngectomy; D008297:Male; D008875:Middle Aged; D037981:Neck Dissection; D009367:Neoplasm Staging; D016016:Proportional Hazards Models; D020127:Recovery of Function; D012189:Retrospective Studies; D018709:Statistics, Nonparametric; D015996:Survival Rate; D016896:Treatment Outcome