title: Revascularization with and without platelet-rich plasma in nonvital, immature, anterior teeth: a pilot clinical study.
abstract: BACKGROUND
  This study was conducted to evaluate and compare maturogenesis induced by revascularization with and without platelet-rich plasma (PRP).
  
  
  METHODS
  Twenty patients with nonvital, immature anterior teeth were randomly categorized into 2 groups. Subsequent to chemomechanical preparation, revascularization with and without PRP carried on a collagen sponge was induced in groups 1 and 2, respectively. The cases were followed up clinically and radiographically at 6- and 12-month intervals.
  
  
  RESULTS
  Clinically, all cases were asymptomatic with complete resolution of signs and symptoms. Radiographically, there was a marked difference in periapical healing, apical closure, and dentinal wall thickening in group 2 in comparison with group 1. However, root lengthening was comparable for both of the procedures.
  
  
  CONCLUSIONS
  Revascularization is a conservative and an effective method for inducing maturogenesis in nonvital, immature teeth. Supplementations with PRP can potentially improve the desired biological outcome of this regenerative technique.
authors.affiliation: Department of Conservative Dentistry and Endodontics, Centre for Dental Education and Research, All India Institute of Medical Sciences, New Delhi, India.
authors.forename: Ganesh
authors.initials: G
authors.lastname: Jadhav
authors.forename: Naseem
authors.initials: N
authors.lastname: Shah
authors.forename: Ajay
authors.initials: A
authors.lastname: Logani
mesh_terms: D000293:Adolescent; D000328:Adult; D056624:Apexification / Q000379:methods*; D003804:Dentin / Q000000981:diagnostic imaging; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007180:Incisor / Q000473:pathology; D008297:Male; D018919:Neovascularization, Physiologic / Q000502:physiology*; D009805:Odontogenesis / Q000502:physiology; D010483:Periapical Diseases / Q000628:therapy; D010865:Pilot Projects; D053657:Platelet-Rich Plasma / Q000502:physiology*; D016300:Radiography, Bitewing; D012038:Regeneration / Q000502:physiology; D018915:Root Canal Preparation / Q000379:methods; D054457:Tissue Scaffolds; D019227:Tooth Apex / Q000000981:diagnostic imaging / Q000473:pathology; D019553:Tooth, Nonvital / Q000000981:diagnostic imaging / Q000628:therapy*; D014945:Wound Healing / Q000502:physiology; D055815:Young Adult