title: Determination of some organic contaminants in water samples by solid-phase extraction and liquid chromatography-tandem mass spectrometry.
abstract: Independent methods for determination of organic contaminants such as pharmaceuticals and pesticides in drinking water samples, using SPE as the extraction technique and LC-MS/MS in the MRM mode with electrospray ionization, were developed and validated. Different SPE sorbents were evaluated, including lab-made fluorinated and phenyl and commercial Oasis HLB and C18, with the commercial phases being more suitable for the target compounds. Recoveries in the range of 70-120% were obtained for all target compounds, with the exception for paracetamol (acetaminophen), and precision values (inter-day and intra-day), expressed in terms of relative standard deviations (RSD), lower than 20% were obtained for all target compounds. Quantification limits were in the range of 0.006-0.208 μg L(-1) and the methods developed were successfully applied for the analysis of drinking water samples, detecting some pharmaceuticals and pesticides, but at concentration levels lower than the MRL.
authors.affiliation: Institute of Chemistry, University of Campinas, P.O. Box 6154, 13083-970, Campinas, SP, Brazil.
authors.forename: Liane
authors.initials: L
authors.lastname: Maldaner
authors.forename: Isabel C S F
authors.initials: IC
authors.lastname: Jardim
mesh_terms: D002853:Chromatography, Liquid / Q000379:methods*; D060766:Drinking Water / Q000737:chemistry*; D054879:Halogenation; D009930:Organic Chemicals / Q000032:analysis* / Q000737:chemistry / Q000302:isolation & purification*; D010575:Pesticides / Q000032:analysis / Q000302:isolation & purification; D004364:Pharmaceutical Preparations / Q000032:analysis / Q000737:chemistry / Q000302:isolation & purification; D011108:Polymers / Q000737:chemistry; D015203:Reproducibility of Results; D012822:Silicon Dioxide / Q000737:chemistry; D012833:Siloxanes / Q000737:chemistry; D052616:Solid Phase Extraction / Q000379:methods*; D053719:Tandem Mass Spectrometry / Q000379:methods*; D014874:Water Pollutants, Chemical / Q000032:analysis / Q000737:chemistry / Q000302:isolation & purification; D018508:Water Purification
chemical_list: D060766:Drinking Water; D009930:Organic Chemicals; D010575:Pesticides; D004364:Pharmaceutical Preparations; D011108:Polymers; D012833:Siloxanes; D014874:Water Pollutants, Chemical; D012822:Silicon Dioxide