title: Fluoride release and anti-erosive effects of dentifrices containing PVM/MA copolymers.
abstract: OBJECTIVE
  To evaluate fluoride release from dentine discs and study the effects of dentine tubule occlusion and erosion prevention of dentifrices containing fluoride and PVM/MA copolymers in a cycling erosive challenge model.
  
  
  METHODS
  Human dentine discs, 15 in each group, were eroded by 1.0% citric acid and treated by ProNamel(®) (PRN, 1450ppm fluoride), Colgate(®) Total Sensitive (CTS, 1100ppm fluoride), a prototype dentifrice containing 5000ppm fluoride and 2% PVM/MA copolymers (PVD) and distilled water (control). Fluoride release from each dentine disc was evaluated every 2h in a 12-h period. For cycling erosive challenges, dentine discs were treated by dentifrice slurries twice daily, followed by immersion in saliva and erosive challenges by orange juice. Dentine discs were stored in saliva between treatment cycles and the cycling erosive challenges were repeated for 15 days. On days 5, 10, and 15, size of dentine tubule openings and level of dentine tubule occlusion were evaluated with a 3D scanning microscope.
  
  
  RESULTS
  PVD released more fluorides than other dentifrices in a 12-h period (p<0.05). CTS released more fluorides than PRN at 2, 4, 6, and 8h following a single application (p<0.05). The size of the dentine tubules was smaller and the number of occluded dentine tubules was greater in the CTS and PVD groups than those in the control and PRN groups on day 15 of the erosive challenges.
  
  
  CONCLUSIONS
  Bioadhesive PVM/MA copolymers facilitate fluoride retention and release from dentine discs, and promote dentine tubule occlusion and erosion prevention when combined with hydrated silica particles.
authors.affiliation: Peking University School and Hospital of Stomatology, Beijing, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Wang
authors.forename: Qiufei
authors.initials: Q
authors.lastname: Xie
authors.forename: Tao
authors.initials: T
authors.lastname: Xu
authors.forename: Qin
authors.initials: Q
authors.lastname: Wang
authors.forename: Hans S
authors.initials: HS
authors.lastname: Malmstrom
authors.forename: Yan-Fang
authors.initials: YF
authors.lastname: Ren
mesh_terms: D001628:Beverages; D002327:Cariostatic Agents / Q000737:chemistry* / Q000627:therapeutic use; D019343:Citric Acid / Q000009:adverse effects; D032084:Citrus sinensis; D003692:Delayed-Action Preparations; D003802:Dentifrices / Q000737:chemistry* / Q000627:therapeutic use; D003804:Dentin / Q000187:drug effects / Q000648:ultrastructure; D005459:Fluorides / Q000737:chemistry* / Q000627:therapeutic use; D005638:Fruit; D006801:Humans; D006863:Hydrogen-Ion Concentration; D021621:Imaging, Three-Dimensional / Q000379:methods; D008298:Maleates / Q000737:chemistry*; D008422:Materials Testing; D018613:Microscopy, Confocal / Q000379:methods; D011095:Polyethylenes / Q000737:chemistry*; D012463:Saliva / Q000502:physiology; D013997:Time Factors; D014077:Tooth Erosion / Q000517:prevention & control*
chemical_list: D002327:Cariostatic Agents; D003692:Delayed-Action Preparations; D003802:Dentifrices; D008298:Maleates; D011095:Polyethylenes; D019343:Citric Acid; C043105:poly(methyl vinyl ether-co-maleic anhydride); D005459:Fluorides