title: The short isoform of the CEACAM1 receptor in intestinal T cells regulates mucosal immunity and homeostasis via Tfh cell induction.
abstract: Carcinoembryonic antigen cell adhesion molecule like I (CEACAM1) is expressed on activated T cells and signals through either a long (L) cytoplasmic tail containing immune receptor tyrosine based inhibitory motifs, which provide inhibitory function, or a short (S) cytoplasmic tail with an unknown role. Previous studies on peripheral T cells show that CEACAM1-L isoforms predominate with little to no detectable CEACAM1-S isoforms in mouse and human. We show here that this was not the case in tissue resident T cells of intestines and gut associated lymphoid tissues, which demonstrated predominant expression of CEACAM1-S isoforms relative to CEACAM1-L isoforms in human and mouse. This tissue resident predominance of CEACAM1-S expression was determined by the intestinal environment where it served a stimulatory function leading to the regulation of T cell subsets associated with the generation of secretory IgA immunity, the regulation of mucosal commensalism, and defense of the barrier against enteropathogens.
authors.affiliation: Gastroenterology Division, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
authors.forename: Lanfen
authors.initials: L
authors.lastname: Chen
authors.forename: Zhangguo
authors.initials: Z
authors.lastname: Chen
authors.forename: Kristi
authors.initials: K
authors.lastname: Baker
authors.forename: Elizabeth M
authors.initials: EM
authors.lastname: Halvorsen
authors.forename: Andre Pires
authors.initials: AP
authors.lastname: da Cunha
authors.forename: Magdalena B
authors.initials: MB
authors.lastname: Flak
authors.forename: Georg
authors.initials: G
authors.lastname: Gerber
authors.forename: Yu-Hwa
authors.initials: YH
authors.lastname: Huang
authors.forename: Shuhei
authors.initials: S
authors.lastname: Hosomi
authors.forename: Janelle C
authors.initials: JC
authors.lastname: Arthur
authors.forename: Ken J
authors.initials: KJ
authors.lastname: Dery
authors.forename: Takashi
authors.initials: T
authors.lastname: Nagaishi
authors.forename: Nicole
authors.initials: N
authors.lastname: Beauchemin
authors.forename: Kathryn V
authors.initials: KV
authors.lastname: Holmes
authors.forename: Joshua W K
authors.initials: JW
authors.lastname: Ho
authors.forename: John E
authors.initials: JE
authors.lastname: Shively
authors.forename: Christian
authors.initials: C
authors.lastname: Jobin
authors.forename: Andrew B
authors.initials: AB
authors.lastname: Onderdonk
authors.forename: Lynn
authors.initials: L
authors.lastname: Bry
authors.forename: Howard L
authors.initials: HL
authors.lastname: Weiner
authors.forename: Darren E
authors.initials: DE
authors.lastname: Higgins
authors.forename: Richard S
authors.initials: RS
authors.lastname: Blumberg
mesh_terms: D020816:Amino Acid Motifs / Q000235:genetics / Q000276:immunology; D000818:Animals; D002272:Carcinoembryonic Antigen / Q000235:genetics / Q000276:immunology* / Q000378:metabolism; D003593:Cytoplasm / Q000235:genetics / Q000276:immunology / Q000378:metabolism; D006706:Homeostasis; D018928:Immunity, Mucosal / Q000235:genetics / Q000276:immunology*; D007070:Immunoglobulin A / Q000235:genetics / Q000276:immunology / Q000378:metabolism; D007413:Intestinal Mucosa / Q000378:metabolism; D007422:Intestines / Q000276:immunology*; D008089:Listeria monocytogenes / Q000276:immunology; D008088:Listeriosis / Q000276:immunology; D008213:Lymphocyte Activation; D054892:Metagenome / Q000276:immunology; D051379:Mice; D008810:Mice, Inbred C57BL; D050778:NFATC Transcription Factors / Q000235:genetics / Q000378:metabolism; D020033:Protein Isoforms; D011971:Receptors, Immunologic / Q000235:genetics / Q000276:immunology / Q000378:metabolism; D013601:T-Lymphocytes / Q000276:immunology* / Q000378:metabolism; D014443:Tyrosine / Q000235:genetics / Q000276:immunology / Q000378:metabolism
chemical_list: D002272:Carcinoembryonic Antigen; C486183:Ceacam1 protein, mouse; D007070:Immunoglobulin A; D050778:NFATC Transcription Factors; D020033:Protein Isoforms; D011971:Receptors, Immunologic; D014443:Tyrosine