title: Uterine fibroids affect pregnancy outcome in women over 30 years old: role of other risk factors.
abstract: OBJECTIVE
  To evaluate the pregnancy outcome in women >30 years old with uterine fibroids also considering other possible concomitant risk factors.
  
  
  METHODS
  A multicentric, observational and retrospective study was conducted. All women were asked to complete a questionnaire while they were in hospital and the outcome of pregnancy was investigated.
  
  
  RESULTS
  Women with uterine fibroids before pregnancy were more frequently >35 years old and in their clinical history before pregnancy showed more pelvic pain, polliachiuria, previous pelvic surgery, hypermenorrhea and dysmenorrhea, than control women (p < 0.0001). During pregnancy patients with uterine fibroids showed significantly more threatened preterm birth (PTB) and PTB, weight gain, hyperemesis, gestational hypertension and post-partum bleeding and showed more often requirement for emergency cesarean section (p < 0.0001). The multivariate logistic regression model used for evaluating the effect of clinical parameters on outcome of pregnancy showed that age >35 years, pelvic pain, work, weight gain, hyperemesis, threatened miscarriage and threatened PTB were significantly correlated with unfavorable pregnancy outcome , independently of the presence of uterine fibroids (p < 0.0001).
  
  
  CONCLUSIONS
  The present study confirming a more frequent negative pregnancy outcome in presence of uterine fibroids, showed that other risk factors may affect pregnancy and delivery outcome in women aging >30 years old.
authors.affiliation: Department of Molecular and Developmental Medicine, University of Siena, Siena, Italy.
authors.forename: Nathalie
authors.initials: N
authors.lastname: Conti
authors.forename: Claudia
authors.initials: C
authors.lastname: Tosti
authors.forename: Serena
authors.initials: S
authors.lastname: Pinzauti
authors.forename: Tiziana
authors.initials: T
authors.lastname: Tomaiuolo
authors.forename: Gabriele
authors.initials: G
authors.lastname: Cevenini
authors.forename: Filiberto M
authors.initials: FM
authors.lastname: Severi
authors.forename: Mariarosaria
authors.initials: M
authors.lastname: Di Tommaso
authors.forename: Felice
authors.initials: F
authors.lastname: Petraglia
mesh_terms: D000328:Adult; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D007889:Leiomyoma / Q000150:complications*; D016015:Logistic Models; D008297:Male; D010298:Parity; D011247:Pregnancy; D011248:Pregnancy Complications / Q000209:etiology*; D011256:Pregnancy Outcome; D012189:Retrospective Studies; D012307:Risk Factors