title: A derivative of L-allo threonine alleviates 2,4-dinitrofluorobenzene-induced atopic dermatitis indications.
abstract: LX519290, a synthetic derivative from a combinatorial chemistry library, has been screened for anti-atopic activity, but its biological activities have not yet been elucidated. To assess whether LX519290 has the potential to lessen 2,4-dinitrofluorobenzene-induced atopic dermatitis symptoms in mice, first we sensitized the skin in the dorsal neck of C57BL/6 mice and re-sensitized the ear skin to determine the ear thickness. Then, we tested to determine whether LX519290 affect atopic dermatitis symptoms in vivo. The results indicate that LX519290 significantly mitigated inflammation indications including ear thickness, total T-cell numbers, and eosinophils. Moreover, the treatment drastically inhibited the levels of mediators such as interleukin-17E and histamine by 52% and 37% of control, respectively. Taken together, the data suggest that LX519290 can alleviate atopic parameters in mice.
authors.affiliation: Food and Bio-Industry Research Institute, Kyungpook National University, Daegu 702-701, Korea.
authors.forename: Jin-Chul
authors.initials: JC
authors.lastname: Heo
authors.forename: Hyeong-U
authors.initials: HU
authors.lastname: Son
authors.forename: Solomon L
authors.initials: SL
authors.lastname: Kim
authors.forename: Sang-Han
authors.initials: SH
authors.lastname: Lee
mesh_terms: D000818:Animals; D003876:Dermatitis, Atopic / Q000139:chemically induced* / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology; D004139:Dinitrofluorobenzene / Q000009:adverse effects*; D004817:Epidermis / Q000187:drug effects / Q000378:metabolism / Q000473:pathology; D005786:Gene Expression Regulation / Q000187:drug effects; D006632:Histamine / Q000378:metabolism; D006834:Hydrazines / Q000494:pharmacology* / Q000627:therapeutic use; D020381:Interleukin-17 / Q000378:metabolism; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D010641:Phenotype; D013912:Threonine / Q000031:analogs & derivatives* / Q000494:pharmacology* / Q000627:therapeutic use
chemical_list: D006834:Hydrazines; D020381:Interleukin-17; C581088:LX519290; D013912:Threonine; D006632:Histamine; D004139:Dinitrofluorobenzene