title: Acetylcholinesterase inhibitors from the leaves of Macaranga kurzii.
abstract: Bioassay-guided fractionation of an extract of leaves of Macaranga kurzii yielded four new compounds, a stilbene (furanokurzin, 1) and three flavonoids (macakurzin A-C, 2-4). Nine known compounds were also isolated (5-13). Their structures were determined by spectroscopic analyses including MS and 2D NMR. The isolates were all evaluated for acetylcholinesterase inhibitory activity. Compound 6 (trans-3,5-dimethoxystilbene) exhibited the greatest activity (IC50 9 μM). Cytotoxic evaluation against KB cells showed that compound 7 had an IC50 of 4 μM, followed by 11 (IC50 10 μM) and 3 (IC50 13 μM).
authors.affiliation: Institute of Marine Biochemistry of the Vietnam Academy of Science and Technology (VAST), 18 Hoang Quoc Viet Road, Cau Giay, Hanoi, Vietnam.
authors.forename: Van
authors.initials: V
authors.lastname: Trinh Thi Thanh
authors.forename: Huong
authors.initials: H
authors.lastname: Doan Thi Mai
authors.forename: Van Cuong
authors.initials: VC
authors.lastname: Pham
authors.forename: Marc
authors.initials: M
authors.lastname: Litaudon
authors.forename: Vincent
authors.initials: V
authors.lastname: Dumontet
authors.forename: Françoise
authors.initials: F
authors.lastname: Guéritte
authors.forename: Van Hung
authors.initials: VH
authors.lastname: Nguyen
authors.forename: Van Minh
authors.initials: VM
authors.lastname: Chau
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000494:pharmacology; D002800:Cholinesterase Inhibitors / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D019665:Euphorbiaceae / Q000737:chemistry*; D005419:Flavonoids / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D006801:Humans; D020128:Inhibitory Concentration 50; D007624:KB Cells; D015394:Molecular Structure; D018515:Plant Leaves / Q000737:chemistry; D013267:Stilbenes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D002800:Cholinesterase Inhibitors; D005419:Flavonoids; D013267:Stilbenes; C587523:furanokurzin; C587524:macakurzi A; C587526:macakurzi B; C587525:macakurzi C