title: Salinomycin, a polyether ionophoric antibiotic, inhibits adipogenesis.
abstract: The polyether ionophoric antibiotics including monensin, salinomycin, and narasin, are widely used in veterinary medicine and as food additives and growth promoters in animal husbandry including poultry farming. Their effects on human health, however, are not fully understood. Recent studies showed that salinomycin is a cancer stem cell inhibitor. Since poultry consumption has risen sharply in the last three decades, we asked whether the consumption of meat tainted with growth promoting antibiotics might have effects on adipose cells. We showed in this report that the ionophoric antibiotics inhibit the differentiation of preadipocytes into adipocytes. The block of differentiation is not due to the induction of apoptosis nor the inhibition of cell proliferation. In addition, salinomycin also suppresses the transcriptional activity of the CCAAT/enhancer binding proteins and the peroxisome proliferator-activated receptor γ. These results suggest that the ionophoric antibiotics can be exploited as novel anti-obesity therapeutics and as pharmacological probes for the study of adipose biology. Further, the pharmacological effects of salinomycin could be a harbinger of its toxicity on the adipose tissue and other susceptible target cells in cancer therapy.
authors.affiliation: Department of Medicine, Biochemistry and Cancer Biology, Center for Diabetes and Endocrine Research, College of Medicine, University of Toledo, Toledo, OH 43614, USA.
authors.forename: Maria
authors.initials: M
authors.lastname: Szkudlarek-Mikho
authors.forename: Rudel A
authors.initials: RA
authors.lastname: Saunders
authors.forename: Sook Fan
authors.initials: SF
authors.lastname: Yap
authors.forename: Yun Fong
authors.initials: YF
authors.lastname: Ngeow
authors.forename: Khew-Voon
authors.initials: KV
authors.lastname: Chin
mesh_terms: D050156:Adipogenesis / Q000187:drug effects* / Q000235:genetics; D000818:Animals; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000494:pharmacology*; D022763:CCAAT-Enhancer-Binding Protein-alpha / Q000378:metabolism; D002460:Cell Line; D007476:Ionophores / Q000737:chemistry / Q000494:pharmacology*; D051739:Microphthalmia-Associated Transcription Factor / Q000378:metabolism; D047495:PPAR gamma / Q000378:metabolism; D011401:Promoter Regions, Genetic / Q000187:drug effects; D011714:Pyrans / Q000737:chemistry / Q000494:pharmacology*; D014158:Transcription, Genetic / Q000187:drug effects; D015533:Transcriptional Activation / Q000187:drug effects; D000095662:Polyether Polyketides
chemical_list: D000900:Anti-Bacterial Agents; D022763:CCAAT-Enhancer-Binding Protein-alpha; D007476:Ionophores; D051739:Microphthalmia-Associated Transcription Factor; D047495:PPAR gamma; D011714:Pyrans; C010327:salinomycin; D000095662:Polyether Polyketides