title: Stereoselective total synthesis of FD-891.
abstract: FD-891, a structurally unique 16-membered macrolide having anticancer activity, was synthesized according to a strategy employing asymmetric allylation, Prins cyclization, cross-metathesis reaction, Yamaguchi lactonization, and Julia-Kocienski olefination.
authors.affiliation: Natural Products Chemistry Division I, CSIR-Indian Institute of Chemical Technology, Hyderabad 500 007, India. yadavpub@iict.res.in
authors.forename: J S
authors.initials: JS
authors.lastname: Yadav
authors.forename: Sukant Kishore
authors.initials: SK
authors.lastname: Das
authors.forename: G
authors.initials: G
authors.lastname: Sabitha
mesh_terms: D060326:Chemistry Techniques, Synthetic; D018942:Macrolides / Q000138:chemical synthesis* / Q000737:chemistry*; D013237:Stereoisomerism; D013379:Substrate Specificity
chemical_list: D018942:Macrolides; C091118:FD 891