title: Synovial cell sarcoma of the larynx.
abstract: Synovial cell sarcoma represents a rare group of cancers, particularly in the head and neck region, that typically affects young individuals and has a male preponderance. Prognosis varies with patient age, site and size of the malignancy, degree of necrosis, high level of mitotic activity, and neurovascular invasion. Complete surgical resection of the tumor via partial or total laryngectomy is the first-line treatment in locally invasive disease. CO(2) lasers have been shown to be useful in controlling localized disease. There is also a role for adjuvant radiotherapy. Ifosfamide-based chemotherapy is most useful for malignant disease.
authors.affiliation: Department of Otolaryngology Head and Neck Surgery, Nepean Hospital, Sydney, Australia.
authors.forename: Shruti
authors.initials: S
authors.lastname: Jayachandra
authors.forename: Ronald Y
authors.initials: RY
authors.lastname: Chin
authors.forename: Peter
authors.initials: P
authors.lastname: Walshe
mesh_terms: D006801:Humans; D007822:Laryngeal Neoplasms / Q000175:diagnosis* / Q000453:epidemiology / Q000209:etiology / Q000628:therapy*; D013584:Sarcoma, Synovial / Q000175:diagnosis* / Q000453:epidemiology / Q000209:etiology / Q000628:therapy*