title: Use of human monoclonal antibodies to treat Chikungunya virus infection.
abstract: Chikungunya virus (CHIKV) is an alphavirus prevalent in tropical regions. It causes an acute febrile disease that, in elderly individuals and newborns, is often associated with severe complications. We previously reported the isolation and characterization of 2 human monoclonal antibodies neutralizing CHIKV in vitro: 5F10 and 8B10. Here, we tested their efficacy in vivo as prophylactic and therapeutic treatments of CHIKV infection in AGR129 mice. In both settings, 5F10 and 8B10 were able to significantly delay CHIKV-driven lethality. Our results support the development of prophylactic and therapeutic treatments for CHIKV infection, using a combination of 5F10 and 8B10.
authors.affiliation: Singapore Immunology Network, Agency for Science,  Technology, and Research,  Singapore.
authors.forename: Jan
authors.initials: J
authors.lastname: Fric
authors.forename: Sébastien
authors.initials: S
authors.lastname: Bertin-Maghit
authors.forename: Cheng-I
authors.initials: CI
authors.lastname: Wang
authors.forename: Alessandra
authors.initials: A
authors.lastname: Nardin
authors.forename: Lucile
authors.initials: L
authors.lastname: Warter
mesh_terms: D018354:Alphavirus Infections / Q000276:immunology / Q000401:mortality / Q000517:prevention & control / Q000628:therapy*; D000818:Animals; D000911:Antibodies, Monoclonal / Q000276:immunology / Q000627:therapeutic use*; D000914:Antibodies, Viral / Q000276:immunology / Q000627:therapeutic use; D065632:Chikungunya Fever; D002646:Chikungunya virus / Q000276:immunology*; D004195:Disease Models, Animal; D006801:Humans; D051379:Mice; D016896:Treatment Outcome
chemical_list: D000911:Antibodies, Monoclonal; D000914:Antibodies, Viral