title: Elevated serum S-100B levels in children with temporal lobe epilepsy.
abstract: OBJECTIVE
  An elevated level of S-100B in serum is generally considered to be a biochemical marker of nervous tissue damage. According to our knowledge, no studies have evaluated the serum S-100B protein concentration in children with temporal lobe epilepsy. The objective of this study was to measure the serum levels of S-100B protein in pediatric cases with temporal epilepsy.
  
  
  METHODS
  This case-controlled cross-sectional study was performed at the Department of Pediatric Neurology, Harran University School of Medicine, Sanliurfa, in Turkey. Serum S-100B protein levels were studied in 19 (12 females, 7 males) children with temporal lobe epilepsy and in 25 (15 females, 10 males) healthy control subjects. Serum samples were collected within 30min after a complex partial seizure, and serum S-100B protein levels were measured with an electrochemiluminescence immunoassay for the quantification of protein (ECLIA kit, Roche(®) Diagnostics, Germany).
  
  
  RESULTS
  The mean serum concentration of S-100B protein was 0.12±0.02μg/L in the temporal lobe epilepsy group and 0.07±0.01μg/L in the control group. The patients showed significantly elevated S-100B protein levels compared with healthy controls (P<0.001).
  
  
  CONCLUSIONS
  Our data suggest that increased S-100B protein levels in the serum might reflect neuronal damage in the brains of children with temporal lobe epilepsy. These results do confirm the previous findings of elevated S-100B protein levels in adult patients with temporal lobe epilepsy.
authors.affiliation: Harran University School of Medicine, Department of Pediatric Neurology, Sanliurfa 63100, Turkey. m.calik80@hotmail.com
authors.forename: Mustafa
authors.initials: M
authors.lastname: Calik
authors.forename: Mahmut
authors.initials: M
authors.lastname: Abuhandan
authors.forename: Abdurrahman
authors.initials: A
authors.lastname: Sonmezler
authors.forename: Hasan
authors.initials: H
authors.lastname: Kandemır
authors.forename: Ibrahım
authors.initials: I
authors.lastname: Oz
authors.forename: Abdullah
authors.initials: A
authors.lastname: Taskin
authors.forename: Sahabettin
authors.initials: S
authors.lastname: Selek
authors.forename: Akin
authors.initials: A
authors.lastname: Iscan
mesh_terms: D000293:Adolescent; D015415:Biomarkers / Q000097:blood; D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D003430:Cross-Sectional Studies; D004833:Epilepsy, Temporal Lobe / Q000097:blood* / Q000175:diagnosis* / Q000453:epidemiology; D005260:Female; D006801:Humans; D008297:Male; D009414:Nerve Growth Factors / Q000096:biosynthesis / Q000097:blood*; D064568:S100 Calcium Binding Protein beta Subunit; D009418:S100 Proteins / Q000096:biosynthesis / Q000097:blood*
chemical_list: D015415:Biomarkers; D009414:Nerve Growth Factors; D064568:S100 Calcium Binding Protein beta Subunit; D009418:S100 Proteins