title: Psychosis revealing familial idiopathic basal ganglia calcification.
abstract: We describe the case of a 39-year-old woman presenting with auditory hallucinations and delusions responsive to antipsychotic drugs. Computerized tomography scans revealed basal ganglia calcifications in the proband and in her two asymptomatic parents. Extensive etiological clinicobiological assessment allowed us to exclude known causes of brain calcifications and diagnose familial idiopathic basal ganglia calcification (IBGC). Neurological symptoms associated with psychiatric symptoms are common in IBGC. Nevertheless, purely psychiatric presentations, as demonstrated by the present case, are possible. However, a fortuitous association between asymptomatic IBGC and schizophrenia cannot be ruled out. Only brain imaging, followed by an extensive etiological assessment, allows for diagnosis of this rare disorder.
authors.affiliation: Department of Neurology, Rouen University Hospital, Rouen, France; Inserm U1079, Faculty of Medicine, University of Rouen, Rouen, France. Electronic address: gaelnicolas@hotmail.com.
authors.forename: Gaël
authors.initials: G
authors.lastname: Nicolas
authors.forename: Olivier
authors.initials: O
authors.lastname: Guillin
authors.forename: Alaina
authors.initials: A
authors.lastname: Borden
authors.forename: Sandrine
authors.initials: S
authors.lastname: Bioux
authors.forename: Romain
authors.initials: R
authors.lastname: Lefaucheur
authors.forename: Didier
authors.initials: D
authors.lastname: Hannequin
mesh_terms: D000328:Adult; D001480:Basal Ganglia Diseases / Q000150:complications* / Q000000981:diagnostic imaging; D001921:Brain / Q000000981:diagnostic imaging; D002114:Calcinosis / Q000150:complications* / Q000000981:diagnostic imaging; D005260:Female; D006212:Hallucinations / Q000000981:diagnostic imaging / Q000209:etiology; D006801:Humans; D008279:Magnetic Resonance Imaging; D019636:Neurodegenerative Diseases / Q000150:complications* / Q000000981:diagnostic imaging; D059906:Neuroimaging; D011618:Psychotic Disorders / Q000000981:diagnostic imaging / Q000209:etiology*; D014057:Tomography, X-Ray Computed
keywords: Fahr's disease; Idiopathic basal ganglia calcification; Psychosis