title: Biotransformation of fluorotelomer compound to perfluorocarboxylates in humans.
abstract: Levels of perfluorocarboxylates (PFCAs) in biological compartments have been known for some time but their transport routes and distribution patterns are not properly elucidated. The opinions diverge whether the exposure of the general population occurs indirect through precursors or direct via PFCAs. Previous results showed that ski wax technicians are exposed to levels up to 92 000 ng/m(3) of 8:2 fluorotelomer alcohol (FTOH) via air and have elevated blood levels of PFCAs. Blood samples were collected in 2007-2011 and analyzed for C(4)-C(18) PFCAs, 6:2, 8:2 and 10:2 unsaturated fluorotelomer acids (FTUCAs) and 3:3, 5:3 and 7:3 fluorotelomer acids (FTCAs) using UPLC-MS/MS. Perfluorooctanoic acid (PFOA) was detected in levels ranging from 1.90 to 628 ng/mL whole blood (wb). Metabolic intermediates 5:3 and 7:3 FTCA were detected in all samples at levels up to 6.1 and 3.9 ng/mL wb. 6:2, 8:2 and 10:2 FTUCAs showed maximum levels of 0.07, 0.64 and 0.11 ng/mL wb. Also, for the first time levels of PFHxDA and PFOcDA were detected in the human blood at mean concentrations up to 4.22 ng/mL wb and 4.25 ng/mL wb respectively. The aim of this study was to determine concentrations of PFCAs and FTOH metabolites in blood from ski wax technicians.
authors.affiliation: Man-Technology-Environment (MTM) Research Centre, Örebro University, SE-701 82 Örebro, Sweden. helena.nilsson@oru.se
authors.forename: Helena
authors.initials: H
authors.lastname: Nilsson
authors.forename: Anna
authors.initials: A
authors.lastname: Kärrman
authors.forename: Anna
authors.initials: A
authors.lastname: Rotander
authors.forename: Bert
authors.initials: B
authors.lastname: van Bavel
authors.forename: Gunilla
authors.initials: G
authors.lastname: Lindström
authors.forename: Håkan
authors.initials: H
authors.lastname: Westberg
mesh_terms: D000395:Air Pollutants, Occupational / Q000097:blood / Q000378:metabolism; D001711:Biotransformation; D002210:Caprylates / Q000097:blood / Q000378:metabolism*; D005466:Fluorocarbons / Q000097:blood / Q000378:metabolism*; D006801:Humans; D008297:Male; D016273:Occupational Exposure / Q000706:statistics & numerical data; D012865:Skiing; D053719:Tandem Mass Spectrometry
chemical_list: D000395:Air Pollutants, Occupational; D002210:Caprylates; D005466:Fluorocarbons; C023036:perfluorooctanoic acid