title: Markedly elevated soluble E-cadherin in plasma of patient with pelvic inflammatory disease.
abstract: OBJECTIVE
  To estimate the expression of plasma soluble E-cadherin and the gene polymorphism in patients with pelvic inflammatory disease (PID).
  
  
  METHODS
  Hospital-based case-control study.
  
  
  METHODS
  University hospital.
  
  
  METHODS
  Sixty-four women with PID.
  
  
  METHODS
  Blood specimen collection from patients before and after they received treatment.
  
  
  METHODS
  Enzyme-linked immunosorbent assay and polymerase chain reaction-restriction fragment length polymorphism were respectively used to measure the plasma soluble E-cadherin level and E-cadherin polymorphism.
  
  
  RESULTS
  The level of plasma E-cadherin was significantly elevated in patients with PID as compared with that in normal controls; it decreased significantly after treatment when compared with levels noted in the same patients before they received treatment. When the cutoff level of plasma E-cadherin level was set to 20.22 ng/mL on the basis of receiver-operating characteristic curve (ROC), the sensitivity, specificity, and the area under the curve of plasma E-cadherin level for predicting PID were 0.81, 0.80, and 0.835 (95% confidence interval 0.76-0.90), respectively. The adjusted odds ratio for age, white blood cell count, and C-reactive protein levels was 19.66 (5.48-70.47).
  
  
  CONCLUSIONS
  Elevated plasma soluble E-cadherin expression was involved in the pathogenesis of PID and is useful for the diagnosis of PID.
authors.affiliation: School of Nursing, Chung Shan Medical University, Taichung, Taiwan. tsaihsiuting@yahoo.com.tw
authors.forename: Hsiu-Ting
authors.initials: HT
authors.lastname: Tsai
authors.forename: Tsung-Hsien
authors.initials: TH
authors.lastname: Lee
authors.forename: Shun-Fa
authors.initials: SF
authors.lastname: Yang
authors.forename: Long-Yau
authors.initials: LY
authors.lastname: Lin
authors.forename: Yi-Torng
authors.initials: YT
authors.lastname: Tee
authors.forename: Po-Hui
authors.initials: PH
authors.lastname: Wang
mesh_terms: D000328:Adult; D000368:Aged; D015415:Biomarkers / Q000097:blood; D015820:Cadherins / Q000097:blood* / Q000737:chemistry; D005260:Female; D006801:Humans; D008875:Middle Aged; D000292:Pelvic Inflammatory Disease / Q000097:blood* / Q000175:diagnosis* / Q000453:epidemiology; D015995:Prevalence; D015203:Reproducibility of Results; D012307:Risk Factors; D012680:Sensitivity and Specificity; D012995:Solubility; D013624:Taiwan / Q000453:epidemiology; D055815:Young Adult
chemical_list: D015415:Biomarkers; D015820:Cadherins