title: Pathobiology of Prediabetes in a Biracial Cohort (POP-ABC) study: baseline characteristics of enrolled subjects.
abstract: BACKGROUND
  The Pathobiology of Prediabetes in a Biracial Cohort (POP-ABC) study is a prospective evaluation of the natural history impaired glucose regulation.
  
  
  METHODS
  The eligibility requirements include age 18-65 yr, history of type 2 diabetes in one or both parents, normal fasting plasma glucose (FPG) or normal glucose tolerance, and African-American or Caucasian status. Participants underwent assessments (including dietary and exercise behavior, clinical examination, glucose tolerance, insulin sensitivity, β-cell function, body composition, energy expenditure) during 2.25-5.5 yr of quarterly follow-up. The primary outcome is the occurrence of prediabetes. Baseline data are presented for the 376 enrolled participants. The cohort was also compared with National Health and Nutrition Examination Survey 2007/2008 participants meeting the age and glycemic criteria for the POP-ABC study.
  
  
  RESULTS
  The POP-ABC cohort [mean (±SD) age was 44.2 ± 10.6 yr] was 57.7% African-Americans, 42.3% Caucasians, and 70.7% females; 86% had one parent with diabetes and 14% had both parents affected. Although greater than 70% of the cohort were employed and 75% had more than 13 yr of education, more African-Americans reported incomes less than $20,000 and fewer reported incomes more than $75,000 compared with Caucasians. Compared with Caucasians, African-Americans had a higher body mass index (31.3 ± 7.8 vs. 28.8 ± 7.8 kg/m(2), P = 0.001), a lower FPG (90.0 ± 7.72 vs. 92.2 ± 7.60 mg/dl, P = 0.008), higher glycosylated hemoglobin, lower triglycerides, and similar blood pressure, and homeostasis model assessment of insulin resistance, homeostasis model assessment of β-cell function, high-density lipoprotein, and low-density lipoprotein cholesterol levels. Compared with a cross-section of U.S. subjects (National Health and Nutrition Examination Survey 2007/2008) with normal FPG and normal glucose tolerance, participants in the POP-ABC study had similar lipid profile but were more educated and had higher body mass index, glycosylated hemoglobin, and blood pressure.
  
  
  CONCLUSIONS
  The POP-ABC study has successfully enrolled healthy African-American and Caucasian adults with parental type 2 diabetes mellitus. The study will generate novel data on incidence rates and predictors of prediabetes, and clarify the role of race/ethnicity on early dysglycemia.
authors.affiliation: Department of Medicine, Division of Endocrinology, Diabetes, and Metabolism, University of Tennessee Health Science Center, Memphis, Tennessee 38163, USA. sdj@uthsc.edu
authors.forename: Samuel
authors.initials: S
authors.lastname: Dagogo-Jack
authors.forename: Chimaroke
authors.initials: C
authors.lastname: Edeoga
authors.forename: Sotonte
authors.initials: S
authors.lastname: Ebenibo
authors.forename: Emmanuel
authors.initials: E
authors.lastname: Chapp-Jumbo
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D015331:Cohort Studies; D003924:Diabetes Mellitus, Type 2 / Q000175:diagnosis / Q000453:epidemiology / Q000208:ethnology; D018450:Disease Progression; D005260:Female; D018149:Glucose Intolerance / Q000175:diagnosis / Q000453:epidemiology / Q000208:ethnology; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D018579:Patient Selection; D011236:Prediabetic State / Q000175:diagnosis / Q000453:epidemiology / Q000208:ethnology* / Q000209:etiology*; D011379:Prognosis; D044469:Racial Groups / Q000706:statistics & numerical data; D055815:Young Adult