title: Controversies in granzyme biology.
abstract: Granzymes (Grz) are a family of serine proteases found in the granules of cytotoxic lymphocytes and are emerging as an important group of proteins involved in immune function and surveillance. Grz have both cytotoxic and more recently reported non-cytotoxic roles, however these functions are still subject to thorough investigation. The significance of the cytotoxic and importantly the non-cytotoxic roles of Grz will be discussed in this review, detailing accepted and controversial functions.
authors.affiliation: Cancer Cell Death Laboratory, Peter MacCallum Cancer Centre, East Melbourne, Australia.
authors.forename: O
authors.initials: O
authors.lastname: Susanto
authors.forename: J A
authors.initials: JA
authors.lastname: Trapani
authors.forename: D
authors.initials: D
authors.lastname: Brasacchio
mesh_terms: D000818:Animals; D002448:Cell Adhesion / Q000502:physiology; D016923:Cell Death / Q000502:physiology; D016207:Cytokines / Q000096:biosynthesis; D003602:Cytotoxicity, Immunologic; D005109:Extracellular Matrix / Q000502:physiology; D053804:Granzymes / Q000235:genetics / Q000276:immunology* / Q000502:physiology; D006801:Humans; D007694:Killer Cells, Natural / Q000201:enzymology / Q000276:immunology; D051379:Mice; D008954:Models, Biological; D054353:Perforin / Q000502:physiology; D011110:Polymorphism, Genetic; D051381:Rats; D013045:Species Specificity; D013379:Substrate Specificity; D013602:T-Lymphocytes, Cytotoxic / Q000201:enzymology / Q000276:immunology
chemical_list: D016207:Cytokines; D054353:Perforin; D053804:Granzymes