title: O-GlcNAc modification prevents peptide-dependent acceleration of α-synuclein aggregation.
abstract: Sweet relief: the Parkinson's disease- associated protein α-synuclein is post-translationally modified by N-acetylglucosamine (O-GlcNAc), but the biochemical consequences are unknown. Here we show that an O-GlcNAc-modified peptide does not participate in α-synuclein aggregation, thus suggesting that O-GlcNAc might directly inhibit aggregation in cells.
authors.affiliation: Department of Chemistry, University of Southern California, Los Angeles, CA 90089-0744, USA.
authors.forename: Nicholas P
authors.initials: NP
authors.lastname: Marotta
authors.forename: Carli A
authors.initials: CA
authors.lastname: Cherwien
authors.forename: Tharindumala
authors.initials: T
authors.lastname: Abeywardana
authors.forename: Matthew R
authors.initials: MR
authors.lastname: Pratt
mesh_terms: D000054:Acceleration; D000117:Acetylglucosamine / Q000378:metabolism*; D000595:Amino Acid Sequence; D006031:Glycosylation; D010446:Peptide Fragments / Q000737:chemistry* / Q000378:metabolism*; D055503:Protein Multimerization; D017433:Protein Structure, Secondary; D051844:alpha-Synuclein / Q000737:chemistry*
chemical_list: D010446:Peptide Fragments; D051844:alpha-Synuclein; D000117:Acetylglucosamine