title: Contrast induced exacerbation of renal dysfunction in the advanced chronic kidney disease.
abstract: Contrast media affects renal function, especially in the patients with advanced chronic kidney disease (CKD). The aim of this study was to investigate the characteristics of contrast induced exacerbation of renal dysfunction in the patients with advanced CKD (estimated glomerular filtration rate <30 ml/min/1.73 m(2)). We enrolled 102 advanced CKD patients who underwent cardiac catheterization. Delta creatinine (post-catheterization creatinine minus pre-catheterization creatinine) were calculated. The patients were divided into three groups according to delta creatinine. The highest tertile of the delta creatinine was defined as the exacerbation group. Multivariate logistic regression analyses were performed to find the characteristics of the exacerbation group. Anemia (odds ratio (OR): 15.53, 95% Confidence Interval (95%CI): 1.81-133.27, p = 0.01) and proteinuria (OR: 5.91, 95%CI: 1.64-21.28, p < 0.01) were significant characteristics of the exacerbation group after adjusting confounding factors. In conclusion, anemia and proteinuria were associated with contrast induced exacerbation of renal dysfunction in the advanced CKD patients.
authors.affiliation: Division of Cardiovascular Medicine, Saitama Medical Center, Jichi Medical University, Amanuma 1-847, Omiya-ku, Saitama 330-8503, Japan. yousuke_taniguchi@yahoo.co.jp
authors.forename: Yousuke
authors.initials: Y
authors.lastname: Taniguchi
authors.forename: Kenichi
authors.initials: K
authors.lastname: Sakakura
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Wada
authors.forename: Yoshitaka
authors.initials: Y
authors.lastname: Sugawara
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Funayama
authors.forename: Norifumi
authors.initials: N
authors.lastname: Kubo
authors.forename: Shin-ichi
authors.initials: S
authors.lastname: Momomura
authors.forename: Junya
authors.initials: J
authors.lastname: Ako
mesh_terms: D000368:Aged; D000740:Anemia / Q000139:chemically induced; D006328:Cardiac Catheterization; D003287:Contrast Media / Q000009:adverse effects*; D017023:Coronary Angiography; D003404:Creatinine / Q000097:blood; D005260:Female; D005919:Glomerular Filtration Rate; D006801:Humans; D007668:Kidney / Q000187:drug effects* / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D011507:Proteinuria / Q000139:chemically induced; D051436:Renal Insufficiency, Chronic / Q000503:physiopathology*; D012189:Retrospective Studies
chemical_list: D003287:Contrast Media; D003404:Creatinine