title: New conclusive data on human myocardial dysfunction induced by acidosis.
abstract: Acidosis is one of the major consequences of hemodynamic instability in shock state patients directly associated with multiple organ failure evolution and death. Most studies on the hemodynamic consequences of acidosis have been experimental, nonhuman studies with severe acidosis, and thus far from the most common clinical situations. Schotola and colleagues offer a new approach to human failing myocardium where the authors highlight, ex vivo, the deleterious hemodynamic consequences of mild acidosis. Their work strengthens the current view of the urgent need to discover new efficient and nondeleterious therapy for the treatment of acidosis.
authors.forename: Antoine
authors.initials: A
authors.lastname: Kimmoun
authors.forename: Nicolas
authors.initials: N
authors.lastname: Ducrocq
authors.forename: Bruno
authors.initials: B
authors.lastname: Levy
mesh_terms: D000138:Acidosis / Q000503:physiopathology*; D005260:Female; D006321:Heart / Q000503:physiopathology*; D006333:Heart Failure / Q000503:physiopathology*; D006801:Humans; D008297:Male; D009200:Myocardial Contraction / Q000502:physiology*; D011943:Receptors, Adrenergic, beta / Q000502:physiology*
chemical_list: D011943:Receptors, Adrenergic, beta