title: Saliva and dental erosion.
abstract: Dental erosion is a multifactorial condition. The consideration of chemical, biological and behavioral factors is fundamental for its prevention and therapy. Among the biological factors, saliva is one of the most important parameters in the protection against erosive wear.
  
  
  OBJECTIVE
  This review discusses the role of salivary factors on the development of dental erosion.
  
  
  METHODS
  A search was undertaken on MeDLINe website for papers from 1969 to 2010. The keywords used in the research were "saliva", "acquired pellicle", "salivary flow", "salivary buffering capacity" and "dental erosion". Inclusion of studies, data extraction and quality assessment were undertaken independently and in duplicate by two members of the review team. Disagreements were solved by discussion and consensus or by a third party.
  
  
  RESULTS
  Several characteristics and properties of saliva play an important role in dental erosion. Salivary clearance gradually eliminates the acids through swallowing and saliva presents buffering capacity causing neutralization and buffering of dietary acids. Salivary flow allows dilution of the acids. In addition, saliva is supersaturated with respect to tooth mineral, providing calcium, phosphate and fluoride necessary for remineralization after an erosive challenge. Furthermore, many proteins present in saliva and acquired pellicle play an important role in dental erosion.
  
  
  CONCLUSIONS
  Saliva is the most important biological factor affecting the progression of dental erosion. Knowledge of its components and properties involved in this protective role can drive the development of preventive measures targeting to enhance its known beneficial effects.
authors.affiliation: Department of Biological Sciences, Bauru School of Dentistry, University of São Paulo, Bauru, SP, Brazil. mbuzalaf@fob.usp.br
authors.forename: Marília Afonso Rabelo
authors.initials: MA
authors.lastname: Buzalaf
authors.forename: Angélicas Reis
authors.initials: AR
authors.lastname: Hannas
authors.forename: Melissa Thiemi
authors.initials: MT
authors.lastname: Kato
mesh_terms: D003743:Dental Enamel / Q000737:chemistry; D044622:Dental Pellicle / Q000737:chemistry; D003804:Dentin / Q000737:chemistry; D005459:Fluorides / Q000008:administration & dosage; D006801:Humans; D012463:Saliva / Q000737:chemistry* / Q000502:physiology*; D012471:Salivary Proteins and Peptides / Q000502:physiology; D012472:Salivation / Q000502:physiology; D014077:Tooth Erosion / Q000139:chemically induced*; D014089:Tooth Remineralization
chemical_list: D012471:Salivary Proteins and Peptides; D005459:Fluorides