title: Anti-tumor effects of cationic hybrid liposomes against colon carcinoma along with apoptosis in vitro.
abstract: New-type three-component cationic hybrid liposomes (HLs) composed of dimyristoylphosphatidylcholine (DMPC), polyoxyethylene(21)dodecyl ether (C(12)(EO)(21)) and O,O'-ditetradecanoyl-N-(α-trimethylammonioacetyl) diethanolamine chloride (2C(14)ECl) were produced. Cationic HLs were smaller and more stable than pure DMPC liposomes. It is noteworthy that cationic HLs could remarkably inhibit the growth of human colon cancer (HCT116) cells along with apoptosis in vitro for the first time in this study.
authors.affiliation: Division of Applied Life Science, Graduate School of Engineering, Sojo University, 4–22–1 Ikeda, Kumamoto 860–0082, Japan.
authors.forename: Motoki
authors.initials: M
authors.lastname: Hino
authors.forename: Hideaki
authors.initials: H
authors.lastname: Ichihara
authors.forename: Yoko
authors.initials: Y
authors.lastname: Matsumoto
authors.forename: Ryuichi
authors.initials: R
authors.lastname: Ueoka
mesh_terms: D000970:Antineoplastic Agents / Q000008:administration & dosage*; D017209:Apoptosis / Q000187:drug effects; D002277:Carcinoma; D049109:Cell Proliferation / Q000187:drug effects; D003110:Colonic Neoplasms; D004134:Dimyristoylphosphatidylcholine / Q000008:administration & dosage* / Q000737:chemistry; D004983:Ethanolamines / Q000008:administration & dosage* / Q000737:chemistry; D045325:HCT116 Cells; D006801:Humans; D008081:Liposomes; D053078:Membrane Potential, Mitochondrial / Q000187:drug effects; D009226:Myristates / Q000008:administration & dosage* / Q000737:chemistry; D011092:Polyethylene Glycols / Q000008:administration & dosage* / Q000737:chemistry
chemical_list: D000970:Antineoplastic Agents; D004983:Ethanolamines; D008081:Liposomes; D009226:Myristates; C478049:O,O'-detetradecanoyl-N-(alpha-trimethylammonioacetyl)diethanolamine chloride; D011092:Polyethylene Glycols; D004134:Dimyristoylphosphatidylcholine