title: RASSF1A and ERCC1 expression levels might be predictive of prognosis in advanced, recurrent, and metastatic squamous cell carcinoma of the head and neck treated with docetaxel and cisplatin.
abstract: BACKGROUND
  The purpose of this study was to test the hypothesis that the immunohistochemical expression of ERCC1 and RASSF1A would predict both response to and survival after docetaxel and cisplatin combination chemotherapy in inoperable or recurrent head and neck squamous cell carcinoma.
  
  
  METHODS
  A total of 54 patients were treated with frontline systemic chemotherapy composed of docetaxel (60 mg/m(2)) and cisplatin (65 mg/m(2)), every 3 weeks for up to 6 cycles. The expression levels of ERCC1 and RASSF1A were evaluated in the available 36 prechemotherapy samples.
  
  
  RESULTS
  The overall objective response rate was 35% (complete remission 12% and partial remission 23%). The median progression-free survival and overall survival (OS) times were 5.0 months (95% confidence interval (CI), 3.7-6.4 months) and 24.2 months (95% CI, 3.5-45.0 months), respectively. The status of low ERCC1 and high RASSF1A expression was an independent favorable prognostic factor for OS in multivariate analysis (p = 0.043; hazard ratio, 7.224; 95% CI, 1.060-49.217). Toxicities were comparable with those of previously reported trials.
  
  
  CONCLUSIONS
  Less intensive doses of cisplatin and docetaxel are active but not effective in reducing toxicity. Also, both ERCC1 and RASSF1A might be useful prognostic markers in this regimen.
authors.affiliation: Division of Oncology/Hematology, Department of Internal Medicine, Korea University College of Medicine, Seoul, Korea.
authors.forename: Yong
authors.initials: Y
authors.lastname: Park
authors.forename: Dae S
authors.initials: DS
authors.lastname: Kim
authors.forename: Kyong H
authors.initials: KH
authors.lastname: Park
authors.forename: Seung-Kuk
authors.initials: SK
authors.lastname: Baek
authors.forename: Soon Y
authors.initials: SY
authors.lastname: Kwon
authors.forename: Sang W
authors.initials: SW
authors.lastname: Shin
authors.forename: Kwang Y
authors.initials: KY
authors.lastname: Jung
authors.forename: Chul Y
authors.initials: CY
authors.lastname: Kim
authors.forename: Yeol H
authors.initials: YH
authors.lastname: Kim
authors.forename: Nam J
authors.initials: NJ
authors.lastname: Lee
authors.forename: Jun S
authors.initials: JS
authors.lastname: Kim
authors.forename: In S
authors.initials: IS
authors.lastname: Kim
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage*; D002294:Carcinoma, Squamous Cell / Q000188:drug therapy* / Q000401:mortality / Q000556:secondary*; D002945:Cisplatin / Q000008:administration & dosage; D004268:DNA-Binding Proteins / Q000378:metabolism*; D000077143:Docetaxel; D004720:Endonucleases / Q000378:metabolism*; D005260:Female; D006258:Head and Neck Neoplasms / Q000188:drug therapy* / Q000401:mortality / Q000556:secondary*; D006801:Humans; D015994:Incidence; D008297:Male; D009364:Neoplasm Recurrence, Local / Q000188:drug therapy* / Q000401:mortality; D011379:Prognosis; D056910:Republic of Korea / Q000453:epidemiology; D012307:Risk Factors; D016019:Survival Analysis; D015996:Survival Rate; D043823:Taxoids / Q000008:administration & dosage; D016896:Treatment Outcome; D025521:Tumor Suppressor Proteins / Q000378:metabolism*
chemical_list: D004268:DNA-Binding Proteins; C411762:RASSF1 protein, human; D043823:Taxoids; D025521:Tumor Suppressor Proteins; D000077143:Docetaxel; C071447:ERCC1 protein, human; D004720:Endonucleases; D002945:Cisplatin