title: Akt1, EMSY, BRCA2 and type I IFN signaling: a novel arm of the IFN response.
abstract: Interferon-stimulated transcription is thought to occur mainly through the action of the JAK/STAT pathway. However, recent findings revealed an additional PI3K/Akt-dependent pathway, which contributes to the induction of a set of interferon-stimulated genes (ISGs) through the regulation of the transcriptional repressor EMSY.
authors.affiliation: Molecular Oncology Research Institute, Tufts Medical Center, Boston, MA, USA.
authors.forename: Scott A
authors.initials: SA
authors.lastname: Ezell
authors.forename: Philip N
authors.initials: PN
authors.lastname: Tsichlis
mesh_terms: D024682:BRCA2 Protein / Q000378:metabolism*; D006801:Humans; D007372:Interferons / Q000235:genetics / Q000378:metabolism*; D009363:Neoplasm Proteins / Q000378:metabolism*; D009687:Nuclear Proteins / Q000378:metabolism*; D051057:Proto-Oncogene Proteins c-akt / Q000378:metabolism*; D012097:Repressor Proteins / Q000378:metabolism*; D014158:Transcription, Genetic
chemical_list: D024682:BRCA2 Protein; C480344:EMSY protein, human; D009363:Neoplasm Proteins; D009687:Nuclear Proteins; D012097:Repressor Proteins; D007372:Interferons; D051057:Proto-Oncogene Proteins c-akt
keywords: Akt; BRCA2; EMSY; IRF9; ISRE; JAK/STAT pathway; interferon-stimulated gene (ISG)