title: Regional homogeneity within the default mode network in bipolar depression: a resting-state functional magnetic resonance imaging study.
abstract: OBJECTIVE
  We sought to use a regional homogeneity (ReHo) approach as an index in resting-state functional magnetic resonance imaging (fMRI) to investigate the features of spontaneous brain activity within the default mode network (DMN) in patients suffering from bipolar depression (BD).
  
  
  METHODS
  Twenty-six patients with BD and 26 gender-, age-, and education-matched healthy subjects participated in the resting-state fMRI scans. We compared the differences in ReHo between the two groups within the DMN and investigated the relationships between sex, age, years of education, disease duration, the Hamilton Rating Scale for Depression (HAMD) total score, and ReHo in regions with significant group differences.
  
  
  RESULTS
  Our results revealed that bipolar depressed patients had increased ReHo in the left medial frontal gyrus and left inferior parietal lobe compared to healthy controls. No correlations were found between regional ReHo values and sex, age, and clinical features within the BD group.
  
  
  CONCLUSIONS
  Our findings indicate that abnormal brain activity is mainly distributed within prefrontal-limbic circuits, which are believed to be involved in the pathophysiological mechanisms underlying bipolar depression.
authors.affiliation: Department of Radiology, Beijing Anding Hospital, Capital Medical University, Beijing, China.
authors.forename: Chun-Hong
authors.initials: CH
authors.lastname: Liu
authors.forename: Xin
authors.initials: X
authors.lastname: Ma
authors.forename: Feng
authors.initials: F
authors.lastname: Li
authors.forename: Yong-Jun
authors.initials: YJ
authors.lastname: Wang
authors.forename: Chang-Le
authors.initials: CL
authors.lastname: Tie
authors.forename: Su-Fang
authors.initials: SF
authors.lastname: Li
authors.forename: Tao-Lin
authors.initials: TL
authors.lastname: Chen
authors.forename: Ting-ting
authors.initials: TT
authors.lastname: Fan
authors.forename: Yu
authors.initials: Y
authors.lastname: Zhang
authors.forename: Jie
authors.initials: J
authors.lastname: Dong
authors.forename: Li
authors.initials: L
authors.lastname: Yao
authors.forename: Xia
authors.initials: X
authors.lastname: Wu
authors.forename: Chuan-Yue
authors.initials: CY
authors.lastname: Wang
mesh_terms: D000328:Adult; D000465:Algorithms; D001714:Bipolar Disorder / Q000473:pathology / Q000503:physiopathology*; D001921:Brain / Q000473:pathology; D001931:Brain Mapping / Q000379:methods; D016022:Case-Control Studies; D003863:Depression / Q000175:diagnosis; D005260:Female; D005625:Frontal Lobe / Q000473:pathology; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008875:Middle Aged; D015233:Models, Statistical; D010296:Parietal Lobe / Q000473:pathology; D012044:Regression Analysis