title: HD-CNV: hotspot detector for copy number variants.
abstract: CONCLUSIONS
  Copy number variants (CNVs) are a major source of genetic variation. Comparing CNVs between samples is important in elucidating their potential effects in a wide variety of biological contexts. HD-CNV (hotspot detector for copy number variants) is a tool for downstream analysis of previously identified CNV regions from multiple samples, and it detects recurrent regions by finding cliques in an interval graph generated from the input. It creates a unique graphical representation of the data, as well as summary spreadsheets and UCSC (University of California, Santa Cruz) Genome Browser track files. The interval graph, when viewed with other software or by automated graph analysis, is useful in identifying genomic regions of interest for further study.
  
  
  METHODS
  HD-CNV is an open source Java code and is freely available, with tutorials and sample data from http://daleylab.org.
  
  
  BACKGROUND
  jcamer7@uwo.ca
authors.affiliation: Department of Computer Science, The University of Western Ontario, London, ON, Canada N6A 3K7. jcamer7@uwo.ca
authors.forename: Jenna L
authors.initials: JL
authors.lastname: Butler
authors.forename: Marjorie Elizabeth
authors.initials: ME
authors.lastname: Osborne Locke
authors.forename: Kathleen A
authors.initials: KA
authors.lastname: Hill
authors.forename: Mark
authors.initials: M
authors.lastname: Daley
mesh_terms: D056915:DNA Copy Number Variations; D015894:Genome, Human; D023281:Genomics; D006801:Humans; D059785:Karyotype; D012984:Software