title: Endoscopic ultrasound-guided biopsy of pancreatic metastases: a large single-center experience.
abstract: OBJECTIVE
  This study aimed to describe a single-center experience with endoscopic ultrasound (EUS) features as well as the diagnostic role and clinical impact of EUS-guided fine-needle aspiration (EUS-FNA) and Trucut biopsy (EUS-TCB) in patients with pancreatic metastases.
  
  
  METHODS
  Demographic, clinical, EUS, pathological, clinical outcome, and follow-up data of patients who underwent EUS at our institution between October 1998 and March 2010 for a known or suspected pancreatic metastasis were abstracted.
  
  
  RESULTS
  Forty-nine patients (23 males; median age, 63 years; range 30-83 years) with 72 pancreatic masses were identified. Primary tumor sites included kidney (21), lung (8), skin (6), colon (4), breast (3), small bowel (2), stomach (2), liver (1), ovary (1), and bladder (1). Of the 72 pancreatic lesions, EUS-FNA of 49 was performed (median, 4.1 passes; range, 2-9 passes) without complications. An EUS-TCB after EUS-FNA was performed in 2 patients and confirmed renal cell carcinoma in one and was nondiagnostic in one. The EUS-FNA provided the first diagnosis of "recurrent malignancy" in all the 44 patients at a median time of 65 months (range, 1-348 months) after diagnosis of the primary tumor.
  
  
  CONCLUSIONS
  Endoscopic ultrasound-FNA and EUS-TCB may assist with the cytological diagnosis of pancreatic metastases and may have a major clinical impact.
authors.affiliation: Division of Gastroenterology and Hepatology, School of Medicine, Indiana University, Indianapolis, IN 46202, USA.
authors.forename: Ihab I
authors.initials: II
authors.lastname: El Hajj
authors.forename: Julia K
authors.initials: JK
authors.lastname: LeBlanc
authors.forename: Stuart
authors.initials: S
authors.lastname: Sherman
authors.forename: Mohammad A
authors.initials: MA
authors.lastname: Al-Haddad
authors.forename: Gregory A
authors.initials: GA
authors.lastname: Cote
authors.forename: Lee
authors.initials: L
authors.lastname: McHenry
authors.forename: John M
authors.initials: JM
authors.lastname: DeWitt
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003110:Colonic Neoplasms / Q000175:diagnosis / Q000000981:diagnostic imaging / Q000473:pathology; D003937:Diagnosis, Differential; D061765:Endoscopic Ultrasound-Guided Fine Needle Aspiration / Q000379:methods*; D005260:Female; D006801:Humans; D007680:Kidney Neoplasms / Q000175:diagnosis / Q000000981:diagnostic imaging / Q000473:pathology; D016015:Logistic Models; D008175:Lung Neoplasms / Q000175:diagnosis / Q000000981:diagnostic imaging / Q000473:pathology; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D010179:Pancreas / Q000000981:diagnostic imaging / Q000473:pathology*; D010190:Pancreatic Neoplasms / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000556:secondary*; D012189:Retrospective Studies; D012878:Skin Neoplasms / Q000175:diagnosis / Q000000981:diagnostic imaging / Q000473:pathology