title: TNF-α Polymorphisms in Juvenile Idiopathic Arthritis: Which Potential Clinical Implications?
abstract: Whether tumor necrosis factor alpha (TNF-α) gene polymorphisms (SNPs) influence disease susceptibility and treatment of patients with juvenile idiopathic arthritis (JIA) is presently uncertain. TNF-α is one of the most important cytokine involved in JIA pathogenesis. Several single nucleotide polymorphisms (SNPs) have been identified within the region of the TNF-α gene but only a very small minority have proven functional consequences and have been associated with susceptibility to JIA. An association between some TNF-α SNPs and adult rheumatoid arthritis (RA) susceptibility, severity and clinical response to anti-TNF-α treatment has been reported. The most frenquetly studied TNF-α SNP is located at -308 position, where a substitution of the G allele with the rare A allele has been found. The presence of the allele -308A is associated to JIA and to a poor prognosis. Besides, the -308G genotype has been associated with a better response to anti-TNF-α therapy in JIA patients, confirming adult data. Psoriatic and oligoarticular arthritis are significantly associated to the -238 SNP only in some works. Studies considering other SNPs are conflicting and inconclusive. Large scale studies are required to define the contribution of TNF-α gene products to disease pathogenesis and anti-TNF-α therapeutic efficacy in JIA.
authors.affiliation: Department of Pediatrics, University of Chieti, Via Vestini 5, 66100 Chieti, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Scardapane
authors.forename: L
authors.initials: L
authors.lastname: Breda
authors.forename: M
authors.initials: M
authors.lastname: Lucantoni
authors.forename: F
authors.initials: F
authors.lastname: Chiarelli