title: Human umbilical cord stem cells ameliorate experimental autoimmune encephalomyelitis by regulating immunoinflammation and remyelination.
abstract: Multiple sclerosis (MS) is an irreversible and demyelinating disease of the central nervous system, in part influenced by chronic inflammation. There is no proven effective therapy to stop the pathological progression of MS, although suppressing the immune system to control the inflammatory response may improve the clinical performance acutely. Here, we found that mesenchymal stem cells from human umbilical cord (hUC-MSCs) could restore behavioral functions and attenuate the histopathological deficits of experimental autoimmune encephalomyelitis mice over the long term (i.e., 50 days) by suppression of perivascular immune cell infiltrations and reduction in both demyelination and axonal injury in the spinal cord. These findings suggest that transplantation of hUC-MSCs may be a potential therapy for MS.
authors.affiliation: Department of Neurology, Affiliated Drum Tower Hospital of Nanjing University Medical School , Nanjing, Jiangsu Province, People's Republic of China. xuyun20042001@yahoo.com.cn
authors.forename: Rong
authors.initials: R
authors.lastname: Liu
authors.forename: Zhuo
authors.initials: Z
authors.lastname: Zhang
authors.forename: Zhengjuan
authors.initials: Z
authors.lastname: Lu
authors.forename: Cesar
authors.initials: C
authors.lastname: Borlongan
authors.forename: Jie
authors.initials: J
authors.lastname: Pan
authors.forename: Junhao
authors.initials: J
authors.lastname: Chen
authors.forename: Lai
authors.initials: L
authors.lastname: Qian
authors.forename: Zhuo
authors.initials: Z
authors.lastname: Liu
authors.forename: Lin
authors.initials: L
authors.lastname: Zhu
authors.forename: Jun
authors.initials: J
authors.lastname: Zhang
authors.forename: Yun
authors.initials: Y
authors.lastname: Xu
mesh_terms: D000818:Animals; D018450:Disease Progression; D004681:Encephalomyelitis, Autoimmune, Experimental / Q000276:immunology* / Q000628:therapy*; D005260:Female; D006801:Humans; D007249:Inflammation / Q000276:immunology; D045164:Mesenchymal Stem Cell Transplantation; D059630:Mesenchymal Stem Cells / Q000502:physiology*; D051379:Mice; D008810:Mice, Inbred C57BL; D009103:Multiple Sclerosis / Q000276:immunology; D009186:Myelin Sheath / Q000502:physiology*; D013116:Spinal Cord / Q000378:metabolism; D014470:Umbilical Cord / Q000166:cytology*