title: A sirtuin link between metabolism and heart disease.
abstract: The sirtuins (SIRTs) have gained preeminence for their roles in the response to caloric restriction and the regulation of aging and lifespan. A new study now identifies gene promoters that bind the transcription factor AP1 as targets for silencing by SIRT6, providing possible links between SIRT6 deficiency and dysregulation of insulin-like growth factor signaling, hypertrophic cardiomyopathy and heart failure (pages 1643-1650).
authors.affiliation: Department of Molecular and Cellular Pharmacology, University of Miami Miller School of Medicine, Miami, FL, USA. kwebster@med.miami.edu
authors.forename: Keith A
authors.initials: KA
authors.lastname: Webster
mesh_terms: D000818:Animals; D006332:Cardiomegaly; D006333:Heart Failure; D048031:JNK Mitogen-Activated Protein Kinases; D051058:Oncogene Protein v-akt; D037761:Sirtuins
chemical_list: C501860:Sirt6 protein, mouse; D051058:Oncogene Protein v-akt; D048031:JNK Mitogen-Activated Protein Kinases; D037761:Sirtuins