title: Structural correlates of skilled performance on a motor sequence task.
abstract: The brain regions functionally engaged in motor sequence performance are well-established, but the structural characteristics of these regions and the fiber pathways involved have been less well studied. In addition, relatively few studies have combined multiple magnetic resonance imaging (MRI) and behavioral performance measures in the same sample. Therefore, the current study used diffusion tensor imaging (DTI), probabilistic tractography, and voxel-based morphometry (VBM) to determine the structural correlates of skilled motor performance. Further, we compared these findings with fMRI results in the same sample. We correlated final performance and rate of improvement measures on a temporal motor sequence task (TMST) with skeletonized fractional anisotropy (FA) and whole brain gray matter (GM) volume. Final synchronization performance was negatively correlated with FA in white matter (WM) underlying bilateral sensorimotor cortex-an effect that was mediated by a positive correlation with radial diffusivity. Multi-fiber tractography indicated that this region contained crossing fibers from the corticospinal tract (CST) and superior longitudinal fasciculus (SLF). The identified SLF pathway linked parietal and auditory cortical regions that have been shown to be functionally engaged in this task. Thus, we hypothesize that enhanced synchronization performance on this task may be related to greater fiber integrity of the SLF. Rate of improvement on synchronization was positively correlated with GM volume in cerebellar lobules HVI and V-regions that showed training-related decreases in activity in the same sample. Taken together, our results link individual differences in brain structure and function to motor sequence performance on the same task. Further, our study illustrates the utility of using multiple MR measures and analysis techniques to specify the interpretation of structural findings.
authors.affiliation: Department of Neurology, Max Planck Institute for Human Cognitive and Brain Sciences Leipzig, Germany.
authors.forename: Christopher J
authors.initials: CJ
authors.lastname: Steele
authors.forename: Jan
authors.initials: J
authors.lastname: Scholz
authors.forename: Gwenaëlle
authors.initials: G
authors.lastname: Douaud
authors.forename: Heidi
authors.initials: H
authors.lastname: Johansen-Berg
authors.forename: Virginia B
authors.initials: VB
authors.lastname: Penhune
keywords: diffusion tensor imaging; fractional anisotropy; gray matter volume; individual differences; motor sequence performance; superior longitudinal fasciculus