title: [Personality and neurobiological factors as predictors of treatment efficacy in patients with partial epilepsy].
abstract: In the present study, we attempted to find predictors of the response to antiepileptic treatment with the adjustment for individual constitutional characteristics of patients including the profile of hemispheric asymmetry (right- and left handedness), premorbid personality, predisposition to affective and other mental disorders. We administered a large battery of tests (MMSE, HAM-A, HAM-D, TAS-26 and others). Treatment efficacy was assessed by the degree of seizure frequency reduction and remission duration. Two groups of patients, with 100% reduction of seizures after 12 months of treatment with antiepileptic drugs and with the absence of reduction of seizures, were singled out. It has been shown that left-handedness, cognitive impairment in right-handers, alexithymia and affective disorders in left-handers predict poor treatment efficacy.
authors.forename: A A
authors.initials: AA
authors.lastname: Zemlianaia
authors.forename: V V
authors.initials: VV
authors.lastname: Kalinin
authors.forename: E V
authors.initials: EV
authors.lastname: Zheleznova
authors.forename: L V
authors.initials: LV
authors.lastname: Sokolova
mesh_terms: D000927:Anticonvulsants / Q000627:therapeutic use*; D001824:Body Constitution; D003072:Cognition Disorders / Q000150:complications; D004828:Epilepsies, Partial / Q000188:drug therapy* / Q000503:physiopathology / Q000523:psychology; D005260:Female; D007839:Functional Laterality; D006801:Humans; D008297:Male; D009483:Neuropsychological Tests; D010551:Personality; D011379:Prognosis; D011594:Psychometrics; D012074:Remission Induction; D016896:Treatment Outcome
chemical_list: D000927:Anticonvulsants