title: No association of ZNF804A rs1344706 with white matter integrity in schizophrenia: a tract-based spatial statistics study.
abstract: Altered brain connectivity has been widely considered as a genetic risk mechanism for schizophrenia. Of the many susceptibility genes identified so far, ZNF804A (rs1344706) is the first common genetic variant associated with schizophrenia on a genome-wide level. Previous fMRI studies have found that carriers of rs1344706 exhibit altered functional connectivity. However, the relationship between ZNF804A and white matter structural connectivity in patients of schizophrenia remains unknown. In this study, 100 patients with schizophrenia and 69 healthy controls were genotyped at the single nucleotide polymorphism rs1344706. Diffusion tensor imaging (DTI) was conducted and analyzed with tract-based spatial statistics. Systematic statistical analysis was conducted on multiple diffusion indices, including fractional anisotropy, axial diffusivity, radial diffusivity, and mean diffusivity. Unpaired two-sample t-test revealed significant differences in fractional anisotropy and diffusivity between schizophrenia and control groups. A two-way ANOVA analysis was conducted to assess the main effects of and the interaction between schizophrenia and ZNF804A. Although significant main effects of the diagnosis of schizophrenia were found on radial diffusivity, no association between the ZNF804A (rs1344706) and white matter connectivity was found in the entire group of subjects or in a selected subgroup of age-matched subjects (n=72).
authors.affiliation: Mental Health Institute of The Second Xiangya Hospital, Key Laboratory of Psychiatry and Mental Health of Hunan Province, Central South University, Changsha, Hunan 410011, PR China.
authors.forename: Qinling
authors.initials: Q
authors.lastname: Wei
authors.forename: Zhuang
authors.initials: Z
authors.lastname: Kang
authors.forename: Feici
authors.initials: F
authors.lastname: Diao
authors.forename: Arnaud
authors.initials: A
authors.lastname: Guidon
authors.forename: Xiaoli
authors.initials: X
authors.lastname: Wu
authors.forename: Liangrong
authors.initials: L
authors.lastname: Zheng
authors.forename: Leijun
authors.initials: L
authors.lastname: Li
authors.forename: Xiaofeng
authors.initials: X
authors.lastname: Guo
authors.forename: Maorong
authors.initials: M
authors.lastname: Hu
authors.forename: Jinbei
authors.initials: J
authors.lastname: Zhang
authors.forename: Chunlei
authors.initials: C
authors.lastname: Liu
authors.forename: Jingping
authors.initials: J
authors.lastname: Zhao
mesh_terms: D000293:Adolescent; D000328:Adult; D000704:Analysis of Variance; D016022:Case-Control Studies; D003627:Data Interpretation, Statistical; D056324:Diffusion Tensor Imaging; D005260:Female; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D051741:Kruppel-Like Transcription Factors / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D012559:Schizophrenia / Q000235:genetics* / Q000473:pathology*; D055815:Young Adult
chemical_list: D051741:Kruppel-Like Transcription Factors; C540527:ZNF804A protein, human