title: Use of purified fibrinogen concentrate for dysfibrinogenemia and importance of laboratory fibrinogen activity measurement.
abstract: We report a patient with dysfibrinogenemia treated with purified fibrinogen concentrate who had discrepant post-treatment laboratory values. The patient had mild bleeding symptoms and was diagnosed with dysfibrinogenemia based on fibrinogen activity of 51 mg/dl and antigen of 240 mg/dl. He was treated for an adenoidectomy with purified fibrinogen concentrate (RiaSTAP®) at a dose of 70 mg/kg. A discrepancy in post-treatment fibrinogen activity was observed between the hospital and reference laboratories. Investigation revealed differences in laboratory assay and calibration methods. Fibrinogen concentrate may be a treatment option for patients with dysfibrinogenemia, but accurate laboratory technique is critical for fibrinogen measurement.
authors.affiliation: Department of Pediatrics, Medical College of Wisconsin, Milwaukee, Wisconsin, USA.
authors.forename: Emily B
authors.initials: EB
authors.lastname: Franzblau
authors.forename: Rowena C
authors.initials: RC
authors.lastname: Punzalan
authors.forename: Kenneth D
authors.initials: KD
authors.lastname: Friedman
authors.forename: Angshumoy
authors.initials: A
authors.lastname: Roy
authors.forename: Ozlem
authors.initials: O
authors.lastname: Bilen
authors.forename: Veronica H
authors.initials: VH
authors.lastname: Flood
mesh_terms: D000293:Adolescent; D000347:Afibrinogenemia / Q000188:drug therapy*; D005340:Fibrinogen / Q000032:analysis* / Q000378:metabolism / Q000627:therapeutic use*; D006403:Hematologic Tests / Q000592:standards*; D006801:Humans; D007753:Laboratories; D007755:Laboratories, Hospital; D008297:Male
chemical_list: D005340:Fibrinogen