title: Effect of bilateral oophorectomy on adrenocortical function in women with polycystic ovary syndrome.
abstract: OBJECTIVE
  To determine the impact of ovary-secreted products on adrenocortical function in women with PCOS by studying the adrenocortical response to acute adrenocorticotropic-stimulating hormone (ACTH) stimulation before and after bilateral oophorectomy.
  
  
  METHODS
  Prospective study.
  
  
  METHODS
  Tertiary care medical center.
  
  
  METHODS
  Fourteen women with PCOS, scheduled for bilateral oophorectomy for benign indications, on postoperative transdermal estradiol (E(2)).
  
  
  METHODS
  Physical examination, blood sampling before and after oophorectomy, measurement of hormone levels; assessment of basal (Steroid(0)), maximum stimulated (Steroid(60)), and net increment (ΔSteroid) levels of androstenedione (A4), dehydroepiandrosterone (DHEA), and cortisol (F) before and after ACTH 1-24 stimulation.
  
  
  METHODS
  Preoperative and postoperative basal and ACTH (1-24) stimulated hormone levels.
  
  
  RESULTS
  Total testosterone, free testosterone, and estrone levels decreased, and follicle-stimulating hormone levels statistically significantly increased after oophorectomy. No statistically significant differences in E(2), DHEA sulfate (DHEAS), or sex hormone-binding globulin levels were detected. Basal and ACTH-stimulated A4 levels statistically significantly decreased after oophorectomy, and ΔA4 was statistically significantly increased. No statistically significant differences in DHEA(0), DHEA(60), or F(0) levels were detected. The F(60) and ΔF levels tended to increase after oophorectomy, but the differences did not reach statistical significance.
  
  
  CONCLUSIONS
  Ovarian factors do not appear to contribute significantly to the adrenocortical dysfunction of PCOS.
authors.affiliation: Department of Obstetrics and Gynecology and Center for Androgen-Related Disorders, Cedars-Sinai Medical Center, Los Angeles, California, USA. president@georgiahealth.edu
authors.forename: Ricardo
authors.initials: R
authors.lastname: Azziz
authors.forename: Wendy Y
authors.initials: WY
authors.lastname: Chang
authors.forename: Frank Z
authors.initials: FZ
authors.lastname: Stanczyk
authors.forename: Keslie
authors.initials: K
authors.lastname: Woods
mesh_terms: D000303:Adrenal Cortex Diseases / Q000175:diagnosis* / Q000209:etiology*; D000328:Adult; D005260:Female; D006801:Humans; D008875:Middle Aged; D010052:Ovariectomy / Q000009:adverse effects*; D011085:Polycystic Ovary Syndrome / Q000150:complications* / Q000601:surgery*; D016896:Treatment Outcome