title: Collagen matrix injection combined with flap repair for complex anal fistula.
abstract: Several biomaterials have been proposed to treat anal fistula alone or in combination with other surgical procedures aiming to reduce recurrence rates while minimizing continence impairment. More recently a porcine dermal matrix injection has been proposed as infill biomaterial to treat fistulae. We propose an approach consisting of non-cutting seton positioning followed several weeks later by flap repair associated with dermal matrix injection into the fistula tracts. We report our experience with this two-staged procedure on 24 consecutive patients with complex anal fistulae with a median follow up of > 12 months. In our experience this two-stage approach seems to be safe and effective.
authors.affiliation: Department of Surgery, University of Rome Tor Vergata, Policlinico Tor Vergata, Rome, Italy. piersileri@yahoo.com
authors.forename: P
authors.initials: P
authors.lastname: Sileri
authors.forename: G
authors.initials: G
authors.lastname: Boehm
authors.forename: L
authors.initials: L
authors.lastname: Franceschilli
authors.forename: F
authors.initials: F
authors.lastname: Giorgi
authors.forename: F
authors.initials: F
authors.lastname: Perrone
authors.forename: C
authors.initials: C
authors.lastname: Stolfi
authors.forename: G
authors.initials: G
authors.lastname: Monteleone
authors.forename: A L
authors.initials: AL
authors.lastname: Gaspari
mesh_terms: D000328:Adult; D000368:Aged; D003094:Collagen / Q000008:administration & dosage*; D003131:Combined Modality Therapy; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007267:Injections; D008875:Middle Aged; D010147:Pain Measurement; D011183:Postoperative Complications; D012003:Rectal Fistula / Q000601:surgery*; D012008:Recurrence; D013524:Surgical Flaps; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: C422414:Permacol; D003094:Collagen