title: Preparation of Galipea officinalis Hancock type tetrahydroquinoline alkaloid analogues as anti-tumour agents.
abstract: The preparation of chiral tetrahydroquinolines using Ir-catalysed asymmetric hydrogenation and their possible cytotoxic potential anti-cancer activity were reported. Both of the in vitro cytotoxicity assay on a series of human cancer cell lines including A549 small cell lung cancer, MDA-MB-231 breast cancer, SaoS2 sacroma, SKHep-1 hepatoma and Hep3B hepatocellular carcinoma as well as in vivo animal model using Hep3B hepatocellular tumour xenograft on athymic nude mice suggest that 1,2,3,4-tetrahydroquin-8-ol is a potential anti-tumour alkaloid which may be further developed as a novel cancer chemotherapeutic agent.
authors.affiliation: Department of Applied Biology and Chemical Technology, Hong Kong Polytechnic University, Hung Hom, Hong Kong, China.
authors.forename: Kim-Hung
authors.initials: KH
authors.lastname: Lam
authors.forename: Kenneth Ka-Ho
authors.initials: KK
authors.lastname: Lee
authors.forename: Roberto
authors.initials: R
authors.lastname: Gambari
authors.forename: Raymond Siu-Ming
authors.initials: RS
authors.lastname: Wong
authors.forename: Gregory Yin-Ming
authors.initials: GY
authors.lastname: Cheng
authors.forename: See-Wai
authors.initials: SW
authors.lastname: Tong
authors.forename: Kit-Wah
authors.initials: KW
authors.lastname: Chan
authors.forename: Fung-Yi
authors.initials: FY
authors.lastname: Lau
authors.forename: Paul Bo-San
authors.initials: PB
authors.lastname: Lai
authors.forename: Wai-Yeung
authors.initials: WY
authors.lastname: Wong
authors.forename: Albert Sun-Chi
authors.initials: AS
authors.lastname: Chan
authors.forename: Stanton Hon-Lung
authors.initials: SH
authors.lastname: Kok
authors.forename: Johnny Cheuk-On
authors.initials: JC
authors.lastname: Tang
authors.forename: Chung-Hin
authors.initials: CH
authors.lastname: Chui
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D001943:Breast Neoplasms / Q000188:drug therapy; D005260:Female; D006801:Humans; D006912:Hydroxyquinolines / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D008114:Liver Neoplasms, Experimental / Q000188:drug therapy*; D051379:Mice; D008819:Mice, Nude; D010936:Plant Extracts / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D027821:Rutaceae / Q000737:chemistry*; D012509:Sarcoma / Q000188:drug therapy; D055752:Small Cell Lung Carcinoma / Q000188:drug therapy
chemical_list: C581538:1,2,3,4-tetrahydroquin-8-ol; D000970:Antineoplastic Agents; D006912:Hydroxyquinolines; D010936:Plant Extracts