title: Antibody response in vaccinated pregnant mares to recent G3BP[12] and G14P[12] equine rotaviruses.
abstract: BACKGROUND
  Both the G3P[12] and the G14P[12] type of equine group A rotavirus (RVA) have recently become predominant in many countries, including Japan. G3 types are classified further into G3A and G3B. The G3A viruses have been circulating in Europe, Australia, and Argentina, and the G3B viruses have been circulating in Japan. However, only an inactivated vaccine containing a single G3BP[12] strain is commercially available in Japan. To assess the efficacy of the current vaccine against recently circulating equine RVA strains, we examined antibody responses in pregnant mares to recent G3BP[12] and G14P[12] strains by virus neutralization test.
  
  
  RESULTS
  After vaccination in five pregnant mares, the geometric mean serum titers of virus-neutralizing antibody to recent G3BP[12] strains increased 5.3- to 7.0-fold and were similar to that against homologous vaccine strain. Moreover, antibody titers to recent G14P[12] strains were also increased 3.0- to 3.5-fold.
  
  
  CONCLUSIONS
  These results suggest that inoculation of mares with the current vaccine should provide foals with virus-neutralizing antibodies against not only the G3BP[12] but also the G14P[12] RVA strain via the colostrum.
authors.affiliation: Epizootic Research Center, Equine Research Institute, Japan Racing Association, 1400-4 Shiba, Shimotsuke, Tochigi 329-0412, Japan. nemoto_manabu@epizoo.equinst.go.jp
authors.forename: Manabu
authors.initials: M
authors.lastname: Nemoto
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Tsunemitsu
authors.forename: Harutaka
authors.initials: H
authors.lastname: Murase
authors.forename: Yasuo
authors.initials: Y
authors.lastname: Nambo
authors.forename: Shinsuke
authors.initials: S
authors.lastname: Sato
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Orita
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Imagawa
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Bannai
authors.forename: Koji
authors.initials: K
authors.lastname: Tsujimura
authors.forename: Takashi
authors.initials: T
authors.lastname: Yamanaka
authors.forename: Tomio
authors.initials: T
authors.lastname: Matsumura
authors.forename: Takashi
authors.initials: T
authors.lastname: Kondo
mesh_terms: D000818:Animals; D000914:Antibodies, Viral / Q000097:blood / Q000276:immunology*; D005260:Female; D006734:Horse Diseases / Q000276:immunology* / Q000821:virology; D006736:Horses; D008969:Molecular Sequence Data; D009500:Neutralization Tests / Q000662:veterinary; D010802:Phylogeny; D016133:Polymerase Chain Reaction / Q000662:veterinary; D011247:Pregnancy; D012401:Rotavirus / Q000276:immunology*; D012400:Rotavirus Infections / Q000276:immunology / Q000662:veterinary* / Q000821:virology; D022243:Rotavirus Vaccines / Q000276:immunology*; D017422:Sequence Analysis, DNA / Q000662:veterinary; D015164:Vaccines, Inactivated / Q000276:immunology
chemical_list: D000914:Antibodies, Viral; D022243:Rotavirus Vaccines; D015164:Vaccines, Inactivated