title: Inhaled iloprost as a rescue therapy for transposition of the great arteries with persistent pulmonary hypertension of the newborn.
abstract: Transposition of the great arteries (TGA) in the newborn combined with persistent pulmonary hypertension was reported previously to occur in 3-12 % of full-term neonates with TGA. Right-to-left shunting at the ductal level causes severe hypoxemia despite prostaglandin infusion and balloon atrial septostomy. Although the introduction of inhaled nitric oxide (iNO) has improved the prognosis, this condition still is associated with high preoperative mortality. This report describes the case of a newborn with TGA and persistent pulmonary hypertension, which was managed successfully with oral sildenafil, iNO, and inhaled iloprost during life-threatening acute pulmonary hypertension, thus preventing the use of extracorporeal membrane oxygenation.
authors.affiliation: Neonatal Intensive Care Unit, Department of Neonatology, Hospital Infantil Universitario La Paz, Paseo de la Castellana, 261, 28046, Madrid, Spain, alexavila81@hotmail.com.
authors.forename: Alejandro
authors.initials: A
authors.lastname: Avila-Alvarez
authors.forename: Maria Carmen
authors.initials: MC
authors.lastname: Bravo-Laguna
authors.forename: Lucía Deiros
authors.initials: LD
authors.lastname: Bronte
authors.forename: Maria Jesus
authors.initials: MJ
authors.lastname: Del Cerro
mesh_terms: D000015:Abnormalities, Multiple; D000280:Administration, Inhalation; D006348:Cardiac Surgical Procedures / Q000379:methods; D004305:Dose-Response Relationship, Drug; D005500:Follow-Up Studies; D006801:Humans; D016285:Iloprost / Q000008:administration & dosage*; D007231:Infant, Newborn; D008297:Male; D010547:Persistent Fetal Circulation Syndrome / Q000188:drug therapy* / Q000503:physiopathology; D011669:Pulmonary Wedge Pressure / Q000187:drug effects; D014188:Transposition of Great Vessels / Q000188:drug therapy* / Q000601:surgery; D014665:Vasodilator Agents / Q000008:administration & dosage
chemical_list: D014665:Vasodilator Agents; D016285:Iloprost