title: Expression and significance of vascular endothelial growth factor A and C in leukemia central nervous system metastasis.
abstract: Metastasis to the central nervous system (CNS) is an obstacle for leukemia treatment, the mechanisms of which remain to be elucidated. VEGF-A and VEGF-C are suspected to participate in this process. Paired of cerebrospinal fluid (CSF) and serum samples were collected from leukemia and control cases. Levels of VEGF-A and VEGF-C in both CSF (VEGF-ACSF, VEGF-CCSF) and serum (VEGF-ASerum, VEGF-CSerum) were detected by ELISA. Our data show that higher levels of VEGF-ACSF are closely related to CNS leukemia (CNSL), and VEGF-ACSF may be a better predictor than the other risk factors elucidating the pathogenesis and development of CNSL.
authors.affiliation: Department of Hematology Laboratory, First Affiliated Hospital of Shantou University Medical College, Guangdong, China.
authors.forename: Yue-Ting
authors.initials: YT
authors.lastname: Tang
authors.forename: Fang
authors.initials: F
authors.lastname: Jiang
authors.forename: Li
authors.initials: L
authors.lastname: Guo
authors.forename: Meng-Ya
authors.initials: MY
authors.lastname: Si
authors.forename: Xiao-Yang
authors.initials: XY
authors.lastname: Jiao
mesh_terms: D000293:Adolescent; D000328:Adult; D001812:Blood-Brain Barrier; D016022:Case-Control Studies; D016543:Central Nervous System Neoplasms / Q000556:secondary*; D002648:Child; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D009362:Neoplasm Metastasis; D009369:Neoplasms / Q000473:pathology*; D042461:Vascular Endothelial Growth Factor A / Q000378:metabolism*; D042582:Vascular Endothelial Growth Factor C / Q000378:metabolism*; D055815:Young Adult
chemical_list: D042461:Vascular Endothelial Growth Factor A; D042582:Vascular Endothelial Growth Factor C