title: Honokiol, a multifunctional tumor cell death inducer.
abstract: Honokiol is a small-molecule pharmacologically active component which has various medicinal applications. Increasing interest is paid on its multifunctional anti-tumor effects including inducing tumor cell death, anti-angiogenesis, anti-migration and anti-multiple drug resistance. We addressed a brief summary of the anti-tumor actions and potential applications of honokiol. This review is mainly focused on the multiple types of cell death induced by honokiol, and its potential role in overcoming multiple drug resistance.
authors.affiliation: Cancer Institute, The Key Laboratory of Cancer Prevention and Intervention, China National Ministry of Education, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Tian
authors.forename: Dong
authors.initials: D
authors.lastname: Xu
authors.forename: Yong-Chuan
authors.initials: YC
authors.lastname: Deng
mesh_terms: D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000494:pharmacology* / Q000627:therapeutic use; D017209:Apoptosis / Q000187:drug effects; D001713:Biphenyl Compounds / Q000494:pharmacology* / Q000627:therapeutic use; D016923:Cell Death / Q000187:drug effects*; D002465:Cell Movement / Q000187:drug effects; D019008:Drug Resistance, Neoplasm; D006801:Humans; D017705:Lignans / Q000494:pharmacology* / Q000627:therapeutic use; D000498:Allyl Compounds; D010636:Phenols
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D001713:Biphenyl Compounds; D017705:Lignans; C005499:honokiol; D000498:Allyl Compounds; D010636:Phenols