title: Reproducibility of structural, resting-state BOLD and DTI data between identical scanners.
abstract: Increasingly, clinical trials based on brain imaging are adopting multiple sites/centers to increase their subject pool and to expedite the studies, and more longitudinal studies are using multiple imaging methods to assess structural and functional changes. Careful investigation of the test-retest reliability and image quality of inter- or intra- scanner neuroimaging measurements are critical in the design, statistical analysis and interpretation of results. We propose a framework and specific metrics to quantify the reproducibility and image quality for neuroimaging studies (structural, BOLD and Diffusion Tensor Imaging) collected across identical scanners and following a major hardware repair (gradient coil replacement). We achieved consistent measures for the proposed metrics: structural (mean volume in specific regions and stretch factor), functional (temporal Signal-to-Noise ratio), diffusion (mean Fractional Anisotropy and Mean Diffusivity in multiple regions). The proposed frame work of imaging metrics should be used to perform daily quality assurance testing and incorporated into multi-center studies.
authors.affiliation: Department of Physiology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, United States of America.
authors.forename: Lejian
authors.initials: L
authors.lastname: Huang
authors.forename: Xue
authors.initials: X
authors.lastname: Wang
authors.forename: Marwan N
authors.initials: MN
authors.lastname: Baliki
authors.forename: Lei
authors.initials: L
authors.lastname: Wang
authors.forename: A Vania
authors.initials: AV
authors.lastname: Apkarian
authors.forename: Todd B
authors.initials: TB
authors.lastname: Parrish
mesh_terms: D000328:Adult; D000465:Algorithms; D016880:Anisotropy; D001921:Brain / Q000473:pathology; D056324:Diffusion Tensor Imaging / Q000379:methods*; D004867:Equipment Design; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods; D008297:Male; D008953:Models, Anatomic; D015233:Models, Statistical; D009038:Motion; D015337:Multicenter Studies as Topic; D019047:Phantoms, Imaging; D011786:Quality Control; D015203:Reproducibility of Results; D012984:Software