title: Mannheim carotid intima-media thickness and plaque consensus (2004-2006-2011). An update on behalf of the advisory board of the 3rd, 4th and 5th watching the risk symposia, at the 13th, 15th and 20th European Stroke Conferences, Mannheim, Germany, 2004, Brussels, Belgium, 2006, and Hamburg, Germany, 2011.
abstract: Intima-media thickness (IMT) provides a surrogate end point of cardiovascular outcomes in clinical trials evaluating the efficacy of cardiovascular risk factor modification. Carotid artery plaque further adds to the cardiovascular risk assessment. It is defined as a focal structure that encroaches into the arterial lumen of at least 0.5 mm or 50% of the surrounding IMT value or demonstrates a thickness >1.5 mm as measured from the media-adventitia interface to the intima-lumen interface. The scientific basis for use of IMT in clinical trials and practice includes ultrasound physics, technical and disease-related principles as well as best practice on the performance, interpretation and documentation of study results. Comparison of IMT results obtained from epidemiological and interventional studies around the world relies on harmonization on approaches to carotid image acquisition and analysis. This updated consensus document delineates further criteria to distinguish early atherosclerotic plaque formation from thickening of IMT. Standardized methods will foster homogenous data collection and analysis, improve the power of randomized clinical trials incorporating IMT and plaque measurements and facilitate the merging of large databases for meta-analyses. IMT results are applied to individual patients as an integrated assessment of cardiovascular risk factors. However, this document recommends against serial monitoring in individual patients.
authors.affiliation: Stroke Center Bichat Hospital 46, rue Henri-Huchard, FR–75018 Paris, France. pjtw@noos.fr
authors.forename: P-J
authors.initials: PJ
authors.lastname: Touboul
authors.forename: M G
authors.initials: MG
authors.lastname: Hennerici
authors.forename: S
authors.initials: S
authors.lastname: Meairs
authors.forename: H
authors.initials: H
authors.lastname: Adams
authors.forename: P
authors.initials: P
authors.lastname: Amarenco
authors.forename: N
authors.initials: N
authors.lastname: Bornstein
authors.forename: L
authors.initials: L
authors.lastname: Csiba
authors.forename: M
authors.initials: M
authors.lastname: Desvarieux
authors.forename: S
authors.initials: S
authors.lastname: Ebrahim
authors.forename: R
authors.initials: R
authors.lastname: Hernandez Hernandez
authors.forename: M
authors.initials: M
authors.lastname: Jaff
authors.forename: S
authors.initials: S
authors.lastname: Kownator
authors.forename: T
authors.initials: T
authors.lastname: Naqvi
authors.forename: P
authors.initials: P
authors.lastname: Prati
authors.forename: T
authors.initials: T
authors.lastname: Rundek
authors.forename: M
authors.initials: M
authors.lastname: Sitzer
authors.forename: U
authors.initials: U
authors.lastname: Schminke
authors.forename: J-C
authors.initials: JC
authors.lastname: Tardif
authors.forename: A
authors.initials: A
authors.lastname: Taylor
authors.forename: E
authors.initials: E
authors.lastname: Vicaut
authors.forename: K S
authors.initials: KS
authors.lastname: Woo
mesh_terms: D002318:Cardiovascular Diseases / Q000000981:diagnostic imaging / Q000209:etiology / Q000473:pathology; D002339:Carotid Arteries / Q000000981:diagnostic imaging / Q000473:pathology*; D059168:Carotid Intima-Media Thickness; D006801:Humans; D058226:Plaque, Atherosclerotic / Q000175:diagnosis / Q000000981:diagnostic imaging; D016032:Randomized Controlled Trials as Topic; D018570:Risk Assessment; D012307:Risk Factors; D020521:Stroke / Q000000981:diagnostic imaging / Q000473:pathology*