title: Increased circulating soluble LR11 in patients with acute coronary syndrome.
abstract: BACKGROUND
  LR11 (also so called SorLA or SORL1) is a novel marker of intimal smooth muscle cell (SMC) proliferation. Vascular SMCs play important roles in the development of atherosclerosis interacting with macrophages in a vulnerable plaque of patients with acute coronary syndrome (ACS).The present study determines whether soluble LR11 (sLR11) is associated with ACS.
  
  
  METHODS
  We studied 100 patients with coronary artery disease (CAD) comprising 50 consecutive patients with acute coronary syndrome (ACS; mean age 62.3±13.0 years; male 78.0%) who were successfully treated with percutaneous coronary intervention and 50 age- and sex-matched stable angina pectoris (SAP) patients as control. Concentration of sLR11 was measured by sandwich enzyme-linked immunosorbent assay method.
  
  
  RESULTS
  Circulating sLR11 was significantly increased in patients with ACS compared with SAP (9.88±2.78 vs. 8.18±1.11 ng/ml, p<0.01). Multivariate logistic regression analysis indicated that sLR11 was independently associated with ACS (odds ratio (OR), sLR11 quartile increment, 2.18, 95% confidence interval (CI) 1.21-4.19, p<0.01). Among various biomarkers of acute coronary syndrome, hsCRP were significantly correlated with LR11 (r=0.480, p<0.01).
  
  
  CONCLUSIONS
  There is a statistical significant association between LR11 and ACS and may be a useful biomarker for the development of acute coronary syndrome.
authors.affiliation: Department of Cardiovascular Medicine, Juntendo University Graduate School of Medicine, Tokyo, Japan.
authors.forename: Manabu
authors.initials: M
authors.lastname: Ogita
authors.forename: Katsumi
authors.initials: K
authors.lastname: Miyauchi
authors.forename: Tomotaka
authors.initials: T
authors.lastname: Dohi
authors.forename: Shuta
authors.initials: S
authors.lastname: Tsuboi
authors.forename: Tadashi
authors.initials: T
authors.lastname: Miyazaki
authors.forename: Takayuki
authors.initials: T
authors.lastname: Yokoyama
authors.forename: Ken
authors.initials: K
authors.lastname: Yokoyama
authors.forename: Kazunori
authors.initials: K
authors.lastname: Shimada
authors.forename: Takeshi
authors.initials: T
authors.lastname: Kurata
authors.forename: Meizi
authors.initials: M
authors.lastname: Jiang
authors.forename: Hideaki
authors.initials: H
authors.lastname: Bujo
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Daida
mesh_terms: D054058:Acute Coronary Syndrome / Q000097:blood* / Q000473:pathology / Q000628:therapy; D000368:Aged; D000787:Angina Pectoris / Q000097:blood* / Q000473:pathology; D015415:Biomarkers / Q000097:blood; D002097:C-Reactive Protein / Q000032:analysis; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D026502:LDL-Receptor Related Proteins / Q000097:blood*; D008297:Male; D026901:Membrane Transport Proteins / Q000097:blood*; D008875:Middle Aged; D015999:Multivariate Analysis; D062645:Percutaneous Coronary Intervention
chemical_list: D015415:Biomarkers; D026502:LDL-Receptor Related Proteins; D026901:Membrane Transport Proteins; C102582:SORL1 protein, human; D002097:C-Reactive Protein