title: ACE and AGTR1 polymorphisms in elite rhythmic gymnastics.
abstract: In the angiotensin-converting enzyme (ACE) gene, Alu deletion, in intron 16, is associated with higher concentrations of ACE serum activity and this may be associated with elite sprint and power performance. The Alu insertion is associated with lower ACE levels and this could lead to endurance performance. Moreover, recent studies have identified a single-nucleotide polymorphism of the angiotensin type 1 receptor gene AGTR1, which seems to be related to ACE activity. The aim of this study was to examine the involvement of the ACE and the AGTR1 gene polymorphisms in 28 Italian elite rhythmic gymnasts (age range 21 ± 7.6 years), and compare them to 23 middle level rhythmic gymnasts (age range 17 ± 10.9 years). The ACE D allele was significantly more frequent in elite athletes than in the control population (χ(2)=4.07, p=0.04). Comparisons between the middle level and elite athletes revealed significant differences (p<0.0001) for the ACE DD genotype (OR=6.48, 95% confidence interval=1.48-28.34), which was more frequent in elite athletes. There were no significant differences in the AGTR1 A/C genotype or allele distributions between the middle level and elite athletes. In conclusion, the ACE D allele genotype could be a contributing factor to high-performance rhythmic gymnastics that should be considered in athlete development and could help to identify which skills should be trained for talent promotion.
authors.affiliation: Department of Medicine and Health Sciences, University of Molise, Campobasso, Italy.
authors.forename: Alessandra
authors.initials: A
authors.lastname: Di Cagno
authors.forename: Nadia
authors.initials: N
authors.lastname: Sapere
authors.forename: Marina
authors.initials: M
authors.lastname: Piazza
authors.forename: Giovanna
authors.initials: G
authors.lastname: Aquino
authors.forename: Enzo
authors.initials: E
authors.lastname: Iuliano
authors.forename: Mariano
authors.initials: M
authors.lastname: Intrieri
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Calcagno
mesh_terms: D000293:Adolescent; D000328:Adult; D000483:Alleles; D056352:Athletes; D002648:Child; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D006173:Gymnastics; D006801:Humans; D007558:Italy; D008297:Male; D007703:Peptidyl-Dipeptidase A / Q000235:genetics*; D010641:Phenotype; D010807:Physical Endurance / Q000235:genetics; D011110:Polymorphism, Genetic; D044140:Receptor, Angiotensin, Type 1 / Q000235:genetics*; D013177:Sports; D055815:Young Adult
chemical_list: D044140:Receptor, Angiotensin, Type 1; D007703:Peptidyl-Dipeptidase A