title: Effects of Ibuprofen on orthotopic glioma model in rats.
abstract: OBJECTIVE
  To determine the effects of ibuprofen (Ibp) on the vessel proliferation and necrosis in a rat glioma model.
  
  
  METHODS
  Experimental, randomized interventional trial.
  
  
  METHODS
  1st Neurosurgery Clinic in Bakirkoy Mental Diseases Hospital, Bakirkoy, Istanbul, Turkey, in the year 2010.
  
  
  METHODS
  After stereotactic injection of C6/LacZ rat glioma cells into the Wistar rats brain, the rats were randomly assigned to two treatment groups (group 1, control; group 2, Ibp treatment). Rats were sacrificed 18 days after treatment, and number of intra-/peri-tumoural vessels, microendothelial proliferations, immunohistochemistry and necrotic area were evaluated.
  
  
  RESULTS
  Ibp treatment significantly decreased tumour tissue, intratumoral vessel number and total tumour area level. The level of Ki67 was significantly decreased in the tumour tissue of group 2. Additionally, the total necrotic area / total tumour volume (%) was significantly less in the tumour tissue of the ibuprofen-treated rats compared to the controls.
  
  
  CONCLUSIONS
  The data show that the Ibp produced an important reduction in glioma tumour cell proliferation in the rat model.
authors.affiliation: Department of Neurosurgery, Izzet Baysal Hospital, Bolu, Turkey. yasdagis@gmail.com
authors.forename: Yasar
authors.initials: Y
authors.lastname: Dagêstan
authors.forename: Ismail
authors.initials: I
authors.lastname: Karaca
authors.forename: Erol Rustu
authors.initials: ER
authors.lastname: Bozkurt
authors.forename: Ayhan
authors.initials: A
authors.lastname: Bilir
mesh_terms: D043925:Angiogenesis Inducing Agents; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage / Q000627:therapeutic use*; D001932:Brain Neoplasms / Q000188:drug therapy* / Q000473:pathology; D045744:Cell Line, Tumor / Q000187:drug effects* / Q000473:pathology; D005910:Glioma / Q000188:drug therapy* / Q000473:pathology; D007052:Ibuprofen / Q000008:administration & dosage / Q000627:therapeutic use*; D007150:Immunohistochemistry; D009336:Necrosis; D051381:Rats; D017208:Rats, Wistar; D016896:Treatment Outcome
chemical_list: D043925:Angiogenesis Inducing Agents; D000894:Anti-Inflammatory Agents, Non-Steroidal; D007052:Ibuprofen