title: Renal tubulointerstitial damage is associated with short-term cardiovascular events in patients with myocardial infarction.
abstract: BACKGROUND
  Urinary β2 microglobulin (U-β2MG) is a more sensitive and accurate marker of tubulointerstitial damage. The etiology of glomerular damage is related to the occurrence of major adverse cardiovascular events (MACE) in patients with myocardial infarction (MI); however, the prognostic importance of tubulointerstitial damage in patients with ST-segment elevation MI (STEMI) has not been established. The aim of this study was to elucidate whether renal tubulointerstitial damage is associated with the occurrence of MACE in patients after STEMI undergoing percutaneous coronary intervention.
  
  
  RESULTS
  The degree of renal tubulointerstitial damage was evaluated by measuring the U-β2MG level in 89 consecutive STEMI patients. There were 22 MACEs during the follow-up period. Patients with MACE had higher U-β2MG levels than those without MACE, and the U-β2MG level was an independent predictor for MACE. A Kaplan-Meier analysis revealed that the group with higher U-β2MG levels corrected for urinary creatinine was associated with a greater risk for MACE.
  
  
  CONCLUSIONS
  An elevated U-β2MG level was associated with the occurrence of MACE in STEMI patients who underwent PCI. Renal tubulointerstitial damage is therefore considered to be associated with the occurrence of MACE.
authors.affiliation: Department of Cardiology, Pulmonology, and Nephrology, Yamagata University School of Medicine, Yamagata, Japan.
authors.forename: Akira
authors.initials: A
authors.lastname: Funayama
authors.forename: Tetsuro
authors.initials: T
authors.lastname: Shishido
authors.forename: Takehiko
authors.initials: T
authors.lastname: Miyashita
authors.forename: Shunsuke
authors.initials: S
authors.lastname: Netsu
authors.forename: Yoichiro
authors.initials: Y
authors.lastname: Otaki
authors.forename: Takanori
authors.initials: T
authors.lastname: Arimoto
authors.forename: Hiroki
authors.initials: H
authors.lastname: Takahashi
authors.forename: Takuya
authors.initials: T
authors.lastname: Miyamoto
authors.forename: Tetsu
authors.initials: T
authors.lastname: Watanabe
authors.forename: Tsuneo
authors.initials: T
authors.lastname: Konta
authors.forename: Isao
authors.initials: I
authors.lastname: Kubota
mesh_terms: D000368:Aged; D015906:Angioplasty, Balloon, Coronary; D015415:Biomarkers / Q000652:urine; D015897:Comorbidity; D004562:Electrocardiography; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D053208:Kaplan-Meier Estimate; D007678:Kidney Glomerulus / Q000378:metabolism / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000175:diagnosis / Q000453:epidemiology* / Q000628:therapy; D009395:Nephritis, Interstitial / Q000453:epidemiology* / Q000378:metabolism* / Q000473:pathology; D015995:Prevalence; D011379:Prognosis; D016016:Proportional Hazards Models; D012372:ROC Curve; D012307:Risk Factors; D001613:beta 2-Microglobulin / Q000652:urine*
chemical_list: D015415:Biomarkers; D001613:beta 2-Microglobulin