title: Strategies for the selection of catalytic antibodies against organophosphorus nerve agents.
abstract: Among the strategies aimed at biocompatible means for organophosphorus nerve agents neutralization, immunoglobulins have attracted attention in the 1990's and 2000's both for their ability to immobilize the toxicants, but also for their ability to be turned into enzymatically active antibodies known as catalytic antibodies or abzymes (antibodies--enzymes). We will present here a critical review of the successive strategies used for the selection of these nerve agent-hydrolyzing abzymes, based on hapten design, namely antibodies raised against a wide variety of transition state analogs, and eventually the strategies based on anti-idiotypic antibodies and reactibodies.
authors.affiliation: MM Shemyakin and Yu.A. Ovchinnikov Institute of Bioorganic Chemistry RAS, Moscow, Russia.
authors.forename: Ivan
authors.initials: I
authors.lastname: Smirnov
authors.forename: Alexey
authors.initials: A
authors.lastname: Belogurov
authors.forename: Alain
authors.initials: A
authors.lastname: Friboulet
authors.forename: Patrick
authors.initials: P
authors.lastname: Masson
authors.forename: Alexander
authors.initials: A
authors.lastname: Gabibov
authors.forename: Pierre-Yves
authors.initials: PY
authors.lastname: Renard
mesh_terms: D000818:Animals; D000888:Antibodies, Anti-Idiotypic / Q000302:isolation & purification / Q000378:metabolism / Q000627:therapeutic use; D017151:Antibodies, Catalytic / Q000302:isolation & purification / Q000378:metabolism* / Q000627:therapeutic use*; D000931:Antidotes / Q000302:isolation & purification / Q000378:metabolism / Q000627:therapeutic use; D001665:Binding Sites; D002619:Chemical Warfare Agents / Q000378:metabolism* / Q000633:toxicity*; D015195:Drug Design; D006241:Haptens / Q000737:chemistry / Q000276:immunology; D006801:Humans; D008958:Models, Molecular; D009943:Organophosphorus Compounds / Q000276:immunology / Q000378:metabolism* / Q000633:toxicity*; D015202:Protein Engineering
chemical_list: D000888:Antibodies, Anti-Idiotypic; D017151:Antibodies, Catalytic; D000931:Antidotes; D002619:Chemical Warfare Agents; D006241:Haptens; D009943:Organophosphorus Compounds