title: Interferon-induced central retinal vein thrombosis.
abstract: A middle-aged lady presented with sudden onset of unilateral central retinal vein thrombosis after completing 6 months course of interferon and ribavirin for chronic hepatitis C infection. She had no risk factors and all her thrombophilia workup was normal, however, she was found to be dyslipidemic which may have contributed to atherosclerosis and predispose to thrombosis. Despite anticoagulation, her visual acuity deteriorated. This case illustrates the possibility of unpredictable visual complication of interferon. Frequent eye examination should be undertaken in patients having underlying risk factors like diabetes, hypertension or dyslipidemia undergoing interferon therapy.
authors.affiliation: Department of Medicine, Jinnah Medical College Hospital, Karachi. seedling7602@yahoo.com
authors.forename: Lubna
authors.initials: L
authors.lastname: Nazir
authors.forename: Aamir
authors.initials: A
authors.lastname: Husain
authors.forename: Wahid
authors.initials: W
authors.lastname: Haroon
authors.forename: M Ishaq
authors.initials: MI
authors.lastname: Shaikh
authors.forename: Shahid Azim
authors.initials: SA
authors.lastname: Mirza
authors.forename: Ziaullah
authors.initials: Z
authors.lastname: Khan
mesh_terms: D000924:Anticholesteremic Agents; D000925:Anticoagulants / Q000008:administration & dosage; D000998:Antiviral Agents / Q000009:adverse effects* / Q000627:therapeutic use; D050171:Dyslipidemias / Q000150:complications; D005260:Female; D019698:Hepatitis C, Chronic / Q000150:complications / Q000188:drug therapy*; D006801:Humans; D007372:Interferons / Q000009:adverse effects* / Q000627:therapeutic use; D008875:Middle Aged; D012170:Retinal Vein Occlusion / Q000139:chemically induced* / Q000188:drug therapy; D012254:Ribavirin / Q000009:adverse effects / Q000627:therapeutic use*; D016896:Treatment Outcome; D014792:Visual Acuity
chemical_list: D000924:Anticholesteremic Agents; D000925:Anticoagulants; D000998:Antiviral Agents; D012254:Ribavirin; D007372:Interferons