title: Desirable attributes of vaccines for deployment in low-resource settings.
abstract: A number of product development partnerships are actively developing new vaccines to combat infectious diseases in developing countries. To be effective, the products under development should not only be safe, efficacious, and affordable, but they should also have additional desirable technical attributes, including enhanced stability, efficient packaging, and improved ease of delivery. New technologies are now available to achieve these attributes; however, many of the technologies have yet to be adopted by the vaccine industry. This commentary discusses the opportunities and challenges associated with advancing such attributes, especially vaccine thermostability and dose sparing strategies, and the critical issues that must be addressed to bridge the gap between technology development and product development.
authors.affiliation: PATH, Seattle, Washington 98121, USA. dchen@path.org
authors.forename: Dexiang
authors.initials: D
authors.lastname: Chen
authors.forename: Darin
authors.initials: D
authors.lastname: Zehrung
mesh_terms: D003362:Cost-Benefit Analysis; D003906:Developing Countries / Q000191:economics; D004304:Dosage Forms; D016527:Drug Costs; D055808:Drug Discovery; D004349:Drug Packaging; D004355:Drug Stability; D014943:Global Health; D006292:Health Priorities; D006301:Health Services Needs and Demand; D006801:Humans; D013696:Temperature; D014612:Vaccines / Q000008:administration & dosage / Q000737:chemistry / Q000191:economics / Q000600:supply & distribution
chemical_list: D004304:Dosage Forms; D014612:Vaccines