title: [Comparative effects of difluoromethylornithine and tincture of Siberian ginseng root on radiation carcinogenesis and life span in rats].
abstract: Influence of alpha-difluoromethylornithine (DFMO) and tincture of Siberian ginseng root (TSGR) on radiation carcinogenesis and life span in rats has been studied. The results of the study demonstrate that DFMO as well as TSGR significantly improved survival and decreased incidence and multiplicity of malignant and benign tumors in rats subjected to ionizing radiation. Beneficial effect on the rat survival rate and anticarcinogenic action of DFMO were more expressed compared with TSGR.
authors.forename: V G
authors.initials: VG
authors.lastname: Bespalov
authors.forename: V A
authors.initials: VA
authors.lastname: Aleksandrov
authors.forename: A L
authors.initials: AL
authors.lastname: Semenov
authors.forename: E G
authors.initials: EG
authors.lastname: Kovan'ko
authors.forename: S D
authors.initials: SD
authors.lastname: Ivanov
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000009:adverse effects; D002471:Cell Transformation, Neoplastic / Q000187:drug effects* / Q000528:radiation effects; D000518:Eflornithine / Q000008:administration & dosage / Q000009:adverse effects; D028001:Eleutherococcus; D005260:Female; D005767:Gastrointestinal Diseases / Q000139:chemically induced; D006402:Hematologic Diseases / Q000139:chemically induced; D006801:Humans; D009381:Neoplasms, Radiation-Induced / Q000401:mortality / Q000517:prevention & control; D008517:Phytotherapy; D010936:Plant Extracts / Q000008:administration & dosage / Q000009:adverse effects; D018517:Plant Roots; D011833:Radiation Injuries, Experimental / Q000145:classification / Q000401:mortality / Q000517:prevention & control; D011839:Radiation, Ionizing; D051381:Rats; D015996:Survival Rate; D016896:Treatment Outcome
chemical_list: D000970:Antineoplastic Agents; D010936:Plant Extracts; D000518:Eflornithine