title: Virucidal nanofiber textiles based on photosensitized production of singlet oxygen.
abstract: Novel biomaterials based on hydrophilic polycaprolactone and polyurethane (Tecophilic®) nanofibers with an encapsulated 5,10,5,20-tetraphenylporphyrin photosensitizer were prepared by electrospinning. The doped nanofiber textiles efficiently photo-generate O(2)((1)Δ(g)), which oxidize external chemical and biological substrates/targets. Strong photo-virucidal effects toward non-enveloped polyomaviruses and enveloped baculoviruses were observed on the surface of these textiles. The photo-virucidal effect was confirmed by a decrease in virus infectivity. In contrast, no virucidal effect was detected in the absence of light and/or the encapsulated photosensitizer.
authors.affiliation: Charles University in Prague, Prague, Czech Republic.
authors.forename: Yveta
authors.initials: Y
authors.lastname: Lhotáková
authors.forename: Lukáš
authors.initials: L
authors.lastname: Plíštil
authors.forename: Alena
authors.initials: A
authors.lastname: Morávková
authors.forename: Pavel
authors.initials: P
authors.lastname: Kubát
authors.forename: Kamil
authors.initials: K
authors.lastname: Lang
authors.forename: Jitka
authors.initials: J
authors.lastname: Forstová
authors.forename: Jiří
authors.initials: J
authors.lastname: Mosinger
mesh_terms: D000818:Animals; D000873:Anthracenes / Q000737:chemistry; D000998:Antiviral Agents / Q000494:pharmacology*; D016367:Baculoviridae / Q000187:drug effects; D002213:Capsid / Q000737:chemistry; D051379:Mice; D057139:Nanofibers / Q000737:chemistry* / Q000648:ultrastructure; D010084:Oxidation-Reduction; D017319:Photosensitizing Agents / Q000494:pharmacology*; D011091:Polyesters / Q000737:chemistry; D011120:Polyomavirus / Q000187:drug effects; D011140:Polyurethanes / Q000737:chemistry; D011166:Porphyrins / Q000494:pharmacology; D011995:Recombination, Genetic / Q000235:genetics; D026082:Singlet Oxygen / Q000378:metabolism*; D013784:Textiles; D038301:Virus Inactivation / Q000187:drug effects
chemical_list: D000873:Anthracenes; D000998:Antiviral Agents; D017319:Photosensitizing Agents; D011091:Polyesters; D011140:Polyurethanes; D011166:Porphyrins; C409084:tetraphenylporphyrin; D026082:Singlet Oxygen; C016240:polycaprolactone