title: Streptomycin interference in Jaffe reaction - possible false positive creatinine estimation in excessive dose exposure.
abstract: OBJECTIVE
  To study the potential of commonly used aminoglycoside antibiotics to form non-creatinine chromogen with alkaline picrate reagent.
  
  
  METHODS
  We studied the non-creatinine chromogen formation of various concentrations of streptomycin, amikacin, kanamycin, netilmicin, gentamicin and tobramycin added to known creatinine concentrations by the Jaffe reaction based creatinine estimation.
  
  
  RESULTS
  Only streptomycin above therapeutic concentrations of 10mg/mL interfered in the Jaffe reaction and acted as non-creatinine chromogen.
  
  
  CONCLUSIONS
  Therapeutic doses of the aminoglycosides do not form non-creatinine chromogens.
authors.affiliation: Department of Experimental Medicine and Biotechnology, Postgraduate Institute of Medical Education and Research, Chandigarh 160012, India.
authors.forename: Kirtimaan
authors.initials: K
authors.lastname: Syal
authors.forename: Anand
authors.initials: A
authors.lastname: Srinivasan
authors.forename: Dibyajyoti
authors.initials: D
authors.lastname: Banerjee
mesh_terms: D000583:Amikacin / Q000737:chemistry; D000900:Anti-Bacterial Agents / Q000737:chemistry; D002624:Chemistry, Clinical / Q000379:methods*; D003404:Creatinine / Q000032:analysis* / Q000737:chemistry* / Q000652:urine; D004305:Dose-Response Relationship, Drug; D005189:False Positive Reactions; D005839:Gentamicins / Q000737:chemistry; D006801:Humans; D007612:Kanamycin / Q000737:chemistry; D009428:Netilmicin / Q000737:chemistry; D010851:Picrates / Q000737:chemistry; D013307:Streptomycin / Q000008:administration & dosage* / Q000737:chemistry* / Q000652:urine; D014031:Tobramycin / Q000737:chemistry
chemical_list: D000900:Anti-Bacterial Agents; D005839:Gentamicins; D010851:Picrates; D009428:Netilmicin; D007612:Kanamycin; D000583:Amikacin; C005858:picric acid; D003404:Creatinine; D014031:Tobramycin; D013307:Streptomycin