title: Intracellular free iron and its potential role in ultrahigh-pressure-induced inactivation of Escherichia coli.
abstract: Intracellular free iron of Escherichia coli was determined by whole-cell electron paramagnetic resonance spectrometry. Ultrahigh pressure (UHP) increased both intracellular free iron and cell lethality in a pressure-dose-dependent manner. The iron chelator 2,2'-dipyridyl protected cells against UHP treatments. A mutation that produced iron overload conditions sensitized E. coli to UHP treatment.
authors.affiliation: Department of Food Science and Technology, The Ohio State University, Columbus, Ohio, USA.
authors.forename: Yuan
authors.initials: Y
authors.lastname: Yan
authors.forename: Joy G
authors.initials: JG
authors.lastname: Waite-Cusic
authors.forename: Periannan
authors.initials: P
authors.lastname: Kuppusamy
authors.forename: Ahmed E
authors.initials: AE
authors.lastname: Yousef
mesh_terms: D004578:Electron Spin Resonance Spectroscopy; D004926:Escherichia coli / Q000737:chemistry / Q000502:physiology*; D006874:Hydrostatic Pressure; D007501:Iron / Q000032:analysis / Q000633:toxicity*; D050296:Microbial Viability / Q000187:drug effects*
chemical_list: D007501:Iron