title: Fragmentation of poly(lactic acid) nanosheets and patchwork treatment for burn wounds.
abstract: Freestanding poly(L-lactic acid) (PLLA) nanosheets are mass-produced by a simple combination of a spin-coating-assisted multi-layering process and a peeling technique. The resulting PLLA nanosheets are fragmented by homogenization and then reconstructed into a "patchwork" sheet on various surfaces without any adhesive reagents. The patchwork is shown to offer excellent protection against burn wound infection with Pseudomonas aeruginosa, and may therefore be an alternative to conventional burn therapy for prevention of infection.
authors.affiliation: Department of Life Science and Medical Bioscience, Graduate School of Advanced Science and Engineering, Waseda University, TWIns, 2-2 Wakamatsu-cho, Shinjuku-ku, Tokyo, 162-8480, Japan. y.okamura@tokai-u.jp
authors.forename: Yosuke
authors.initials: Y
authors.lastname: Okamura
authors.forename: Koki
authors.initials: K
authors.lastname: Kabata
authors.forename: Manabu
authors.initials: M
authors.lastname: Kinoshita
authors.forename: Hiromi
authors.initials: H
authors.lastname: Miyazaki
authors.forename: Akihiro
authors.initials: A
authors.lastname: Saito
authors.forename: Toshinori
authors.initials: T
authors.lastname: Fujie
authors.forename: Shinya
authors.initials: S
authors.lastname: Ohtsubo
authors.forename: Daizoh
authors.initials: D
authors.lastname: Saitoh
authors.forename: Shinji
authors.initials: S
authors.lastname: Takeoka
mesh_terms: D000818:Animals; D002056:Burns / Q000382:microbiology / Q000628:therapy*; D019344:Lactic Acid / Q000737:chemistry*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D049329:Nanostructures / Q000737:chemistry* / Q000633:toxicity; D011091:Polyesters; D011108:Polymers / Q000737:chemistry*; D011550:Pseudomonas aeruginosa / Q000187:drug effects; D012867:Skin / Q000473:pathology; D014946:Wound Infection / Q000382:microbiology
chemical_list: D011091:Polyesters; D011108:Polymers; D019344:Lactic Acid; C033616:poly(lactide)