title: [Detection and clinical significance of Th1/Th2 cytokines in patients with idiopathic thrombocytopenic purpura].
abstract: OBJECTIVE
  To observe Th1 (IL-2 and IFN-γ) and Th2 (IL-4,  IL-10) cytokine changes in patients with idiopathic thrombocytopenic purpura (ITP) and explore the correlation between ITP development and Th1/Th2.
  
  
  METHODS
  A total of 30 patients with ITP and 26 healthy volunteers were enrolled in this study. Serum levels of IL-2,  IFN-γ,  IL-4,  and IL-10 were detected by enzyme-linked immunosorbent assay (ELISA) before and after treatment.
  
  
  RESULTS
  The serum levels of IFN-γ and IL-2 in patients with ITP before the glucocorticoid treatment were significantly higher than those after the treatment and in the control groups (P<0.05),  while the serum levels of IL-4 and IL-10 in patients with ITP before treatment were significantly lower than those after the treatment and in the control group (P<0.05).
  
  
  CONCLUSIONS
  Th1/Th2 imbalance plays a prominent role in the development of ITP,  and glucocorticoid treatment helps to restore the Th1/Th2 in the patients with ITP.
authors.affiliation: Department of Hematology, Xinjiang Medical University, Urumqi, China. guoxinhong222@sina.cn
authors.forename: Xin-hong
authors.initials: XH
authors.lastname: Guo
authors.forename: Fang
authors.initials: F
authors.lastname: Zhao
authors.forename: Wei
authors.initials: W
authors.lastname: Shi
authors.forename: Xiu-min
authors.initials: XM
authors.lastname: Ma
authors.forename: Qi
authors.initials: Q
authors.lastname: Xu
authors.forename: A-bu-li-zi
authors.initials: AB
authors.lastname: Patiguli
authors.forename: Ya-sen
authors.initials: YS
authors.lastname: Halida
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D016207:Cytokines / Q000097:blood*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D016553:Purpura, Thrombocytopenic, Idiopathic / Q000209:etiology / Q000276:immunology*; D018417:Th1 Cells / Q000276:immunology*; D018418:Th2 Cells / Q000276:immunology*
chemical_list: D016207:Cytokines