title: Stressed out: endogenous aldehydes damage hematopoietic stem cells.
abstract: Despite a well-defined role for the Fanconi anemia (FA) pathway in mediating DNA repair, the mechanisms underlying the bone marrow failure in FA patients are poorly defined. Recently in Nature, Garaycoechea et al. (2012), identify aldehyde-mediated genotoxicity of hematopoietic stem cells as a cause for bone marrow failure.
authors.affiliation: Department of Radiation Oncology, Dana-Farber Cancer Institute, Harvard Medical School, 450 Brookline Avenue, Boston, MA 02215, USA.
authors.forename: Kalindi
authors.initials: K
authors.lastname: Parmar
authors.forename: Alan D
authors.initials: AD
authors.lastname: D'Andrea