title: Protein-size molecularly imprinted polymer nanogels as synthetic antibodies, by localized polymerization with multi-initiators.
abstract: A new approach is proposed for the synthesis of molecularly imprinted polymers (MIPs) (synthetic antibodies) as soluble nanogels with sizes close to the size of real antibodies. To imprint a molecular memory in particles consisting of only a few polymer chains, an initiator carrying multiple iniferter moieties is used. This allows for the simultaneous initiation of several polymer chains, and yields molecularly imprinted nanogels (17 nm, molecular weight (MW) = 97 kDa) with good affinity and selectivity for the target.
authors.affiliation: UMR CNRS 6022, Compiègne University of Technology, Compiègne, France.
authors.forename: Pinar
authors.initials: P
authors.lastname: Cakir
authors.forename: Arnaud
authors.initials: A
authors.lastname: Cutivet
authors.forename: Marina
authors.initials: M
authors.lastname: Resmini
authors.forename: Bernadette Tse Sum
authors.initials: BT
authors.lastname: Bui
authors.forename: Karsten
authors.initials: K
authors.lastname: Haupt
mesh_terms: D000906:Antibodies / Q000737:chemistry / Q000378:metabolism*; D040761:Biomimetic Materials / Q000138:chemical synthesis* / Q000737:chemistry; D054802:Molecular Imprinting; D000080385:Nanogels; D011092:Polyethylene Glycols / Q000737:chemistry*; D011094:Polyethyleneimine / Q000737:chemistry*; D058105:Polymerization; D011108:Polymers / Q000737:chemistry*; D014466:Ultraviolet Rays
chemical_list: D000906:Antibodies; D000080385:Nanogels; D011108:Polymers; C413692:polyethylene glycol polyethyleneimine nanogel; D011092:Polyethylene Glycols; D011094:Polyethyleneimine