title: The Chinese Pueraria root extract (Pueraria lobata) ameliorates impaired glucose and lipid metabolism in obese mice.
abstract: The incidence of type 2 diabetes and metabolic disease is rapidly increasing, but effective therapies for their prevention and treatment have been poorly tolerated or minimally effective. In this study, chronic administration of kudzu root extract (8 months, 0.2%, w/w, in diet) decreased baseline fasting plasma glucose (183±14 vs. 148±11 mg/dl) and improved glucose and insulin tolerance in C57BL/6J ob/ob mice (1.67±0.17 ng/ml [kudzu treated] vs. 2.35±0.63 ng/ml [control]), but such treatment did not alter these parameters in lean control mice. Among the mice on the kudzu supplementation, plasma levels of isoflavone metabolites were significantly higher in ob/ob versus lean control mice, and unmetabolized puerarin (11.50±5.63 ng/g) was found in adipose tissue only in the treated mice. Together, these data demonstrate that a puerarin containing kudzu diet improves glucose and insulin responsiveness in ob/ob mice, suggesting that puerarin may be a beneficial adjuvant for treating metabolic disease.
authors.affiliation: Department of Pharmacology and Toxicology, University of Alabama at Birmingham, Birmingham, AL 35294, USA.
authors.forename: Jeevan K
authors.initials: JK
authors.lastname: Prasain
authors.forename: Ning
authors.initials: N
authors.lastname: Peng
authors.forename: Rajani
authors.initials: R
authors.lastname: Rajbhandari
authors.forename: J Michael
authors.initials: JM
authors.lastname: Wyss
mesh_terms: D000273:Adipose Tissue / Q000187:drug effects / Q000378:metabolism; D000818:Animals; D001786:Blood Glucose / Q000378:metabolism*; D019587:Dietary Supplements; D004365:Drugs, Chinese Herbal / Q000378:metabolism / Q000494:pharmacology / Q000627:therapeutic use; D018149:Glucose Intolerance / Q000188:drug therapy* / Q000378:metabolism; D007004:Hypoglycemic Agents / Q000378:metabolism / Q000494:pharmacology / Q000627:therapeutic use; D000960:Hypolipidemic Agents / Q000378:metabolism / Q000494:pharmacology / Q000627:therapeutic use; D007333:Insulin Resistance; D007529:Isoflavones / Q000378:metabolism / Q000494:pharmacology / Q000627:therapeutic use; D050356:Lipid Metabolism / Q000187:drug effects*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D018345:Mice, Knockout; D008820:Mice, Obese; D009765:Obesity / Q000188:drug therapy* / Q000378:metabolism; D008517:Phytotherapy; D018517:Plant Roots; D029908:Pueraria / Q000737:chemistry*; D012016:Reference Values
chemical_list: D001786:Blood Glucose; D004365:Drugs, Chinese Herbal; D007004:Hypoglycemic Agents; D000960:Hypolipidemic Agents; D007529:Isoflavones; C033607:puerarin