title: [Questions--answers on the use of rivaroxaban for the treatment of venous thromboembolic disease].
abstract: Rivaroxaban is a direct oral anticoagulant targeting factor Xa. Efficacy and safety of rivaroxaban were evaluated through the phase 3 EINSTEIN program, consisting in three clinical trials regarding the treatment of deep vein thrombosis (EINSTEIN DVT), pulmonary embolism (EINSTEIN PE), and in secondary prevention after a first episode of venous thromboembolic disease (EISNTEIN EXT). Rivaroxaban was recently approved both by the European and the French Health agencies for the treatment of DVT and prevention of deep vein thrombosis recurrence. This report addresses the use of rivaroxaban in clinical practice in such indications.
authors.affiliation: Département de Médecine Vasculaire, UJF-Grenoble 1/CNRS TIMC-IMAG UMR 5525/Themas, CHU de Grenoble, BP 217, 38043 Grenoble cedex 9, France. GPernod@chu-grenoble.fr
authors.forename: G
authors.initials: G
authors.lastname: Pernod
authors.forename: A
authors.initials: A
authors.lastname: Elias
authors.forename: I
authors.initials: I
authors.lastname: Gouin
authors.forename: C
authors.initials: C
authors.lastname: Gaillard
authors.forename: P
authors.initials: P
authors.lastname: Nguyen
authors.forename: P
authors.initials: P
authors.lastname: Ouvry
authors.forename: P
authors.initials: P
authors.lastname: Sié
mesh_terms: D000367:Age Factors; D000925:Anticoagulants / Q000627:therapeutic use*; D004347:Drug Interactions; D015951:Factor Xa; D005602:France; D006470:Hemorrhage / Q000139:chemically induced; D006801:Humans; D009025:Morpholines / Q000009:adverse effects / Q000494:pharmacology / Q000627:therapeutic use*; D011655:Pulmonary Embolism / Q000188:drug therapy*; D012307:Risk Factors; D000069552:Rivaroxaban; D013876:Thiophenes / Q000009:adverse effects / Q000494:pharmacology / Q000627:therapeutic use*; D054556:Venous Thromboembolism / Q000188:drug therapy*; D020246:Venous Thrombosis / Q000188:drug therapy*; D014815:Vitamins / Q000037:antagonists & inhibitors
chemical_list: D000925:Anticoagulants; D009025:Morpholines; D013876:Thiophenes; D014815:Vitamins; D000069552:Rivaroxaban; D015951:Factor Xa