title: Effective Friedel-Crafts acylation of biotin acid chloride in trifluoromethanesulfonic acid.
abstract: Biotin is one of the most useful tags in (bio)analytical science due to its specific interaction with avidin, but is not easy to convert because of its low solubility in most solvents. Friedel-Crafts acylation of biotin acid chloride in triflic acid was examined, and the synthesized derivatives had stronger affinity to avidin than biotin in a binding assay using 2-(4'-hydroxyphenylazo)benzoic acid.
authors.affiliation: Division of Applied Science, Graduate School of Agriculture, Hokkaido University, Kita 9, Nishi 9, Sapporo 060-8589, Japan.
authors.forename: Yasuyuki
authors.initials: Y
authors.lastname: Muto
authors.forename: Yuta
authors.initials: Y
authors.lastname: Murai
authors.forename: Yasuko
authors.initials: Y
authors.lastname: Sakihama
authors.forename: Yasuyuki
authors.initials: Y
authors.lastname: Hashidoko
authors.forename: Makoto
authors.initials: M
authors.lastname: Hashimoto
mesh_terms: D000215:Acylation; D001710:Biotin / Q000031:analogs & derivatives* / Q000737:chemistry; D006841:Hydrocarbons, Aromatic / Q000737:chemistry; D008698:Mesylates / Q000737:chemistry*
chemical_list: D006841:Hydrocarbons, Aromatic; D008698:Mesylates; D001710:Biotin; C012077:trifluoromethanesulfonic acid