title: Does BCG revaccination protect against the development of asthma?
abstract: Single BCG vaccination has been considered as a protective factor against asthma. However the effect of a second dose of BCG on the prevalence rate of asthma and asthma-allergic rhinitis-eczema comorbidity has not been studied exclusively among adolescents. In this ISAAC protocol-based cross sectional study we assessed the association between one single versus two doses of BCG among 2213 individuals aged 13-14 years old. We found no association between BCG revaccination and asthma, associated (OR = 0.68, 95% CI, 0.37-1.25) or not to allergic rhinitis and/or atopic eczema (OR = 1.07, 95% CI, 0.84-1.36).
authors.affiliation: Medical School, Department of Pediatrics, Federal University of Minas Gerais, Brazil.
authors.forename: Cláudia Ribeiro
authors.initials: CR
authors.lastname: de Andrade
authors.forename: Sérgio Souza
authors.initials: SS
authors.lastname: da Cunha
authors.forename: Cristina Gonçalves
authors.initials: CG
authors.lastname: Alvim
authors.forename: Maria Jussara Fernandes
authors.initials: MJ
authors.lastname: Fontes
authors.forename: Renata
authors.initials: R
authors.lastname: Bedran
authors.forename: Henrique A
authors.initials: HA
authors.lastname: Binato
authors.forename: Paulo
authors.initials: P
authors.lastname: Camargos
mesh_terms: D000293:Adolescent; D001249:Asthma / Q000453:epidemiology / Q000517:prevention & control*; D001500:BCG Vaccine; D001938:Brazil / Q000453:epidemiology; D003430:Cross-Sectional Studies; D003876:Dermatitis, Atopic / Q000453:epidemiology / Q000517:prevention & control; D006801:Humans; D007117:Immunization, Secondary; D015995:Prevalence; D012221:Rhinitis, Allergic, Perennial / Q000453:epidemiology / Q000517:prevention & control; D006255:Rhinitis, Allergic, Seasonal / Q000453:epidemiology / Q000517:prevention & control
chemical_list: D001500:BCG Vaccine