title: Association of soluble endothelial protein C receptor plasma levels and PROCR rs867186 with cardiovascular risk factors and cardiovascular events in coronary artery disease patients: the Athero Gene study.
abstract: BACKGROUND
  Blood coagulation is an essential determinant of coronary artery disease (CAD). Soluble Endothelial Protein C Receptor (sEPCR) may be a biomarker of a hypercoagulable state. We prospectively investigated the relationship between plasma sEPCR levels and the risk of cardiovascular events (CVE).
  
  
  METHODS
  We measured baseline sEPCR levels in 1673 individuals with CAD (521 with acute coronary syndrome [ACS] and 1152 with stable angina pectoris [SAP]) from the AtheroGene cohort. During a median follow up of 3.7 years, 136 individuals had a CVE. In addition, 891 of these CAD patients were genotyped for the PROCR rs867186 (Ser219Gly) variant.
  
  
  RESULTS
  At baseline, sEPCR levels were similar in individuals with ACS and SAP (median: 111 vs. 115 ng/mL respectively; p=0.20). Increased sEPCR levels were found to be associated with several cardiovascular risk factors including gender (p=0.006), soluble Tissue Factor levels (p=0.0001), diabetes (p=0.0005), and factors reflecting impaired renal function such as creatinine and cystatin C (p<0.0001). sEPCR levels were not significantly associated with the risk of CVE (median: 110 and 114 ng/mL in individuals with and without future CVE respectively; p=0.68). The rs867186 variant was found to explain 59% of sEPCR levels variability (p<10-200) but did not associate with CVE risk.
  
  
  CONCLUSIONS
  Our findings show that in patients with CAD, circulating sEPCR levels are related to classical cardiovascular risk factors and renal impairment but are not related to long-term incidence of CVE.
authors.affiliation: INSERM UMR, Aix-Marseille Université, France.
authors.forename: Choumous
authors.initials: C
authors.lastname: Kallel
authors.forename: William
authors.initials: W
authors.lastname: Cohen
authors.forename: Noémie
authors.initials: N
authors.lastname: Saut
authors.forename: Stefan
authors.initials: S
authors.lastname: Blankenberg
authors.forename: Renate
authors.initials: R
authors.lastname: Schnabel
authors.forename: Hans J
authors.initials: HJ
authors.lastname: Rupprecht
authors.forename: Christoph
authors.initials: C
authors.lastname: Bickel
authors.forename: Thomas
authors.initials: T
authors.lastname: Munzel
authors.forename: David-Alexandre
authors.initials: DA
authors.lastname: Tregouet
authors.forename: Pierre-Emmanuel
authors.initials: PE
authors.lastname: Morange
mesh_terms: D054058:Acute Coronary Syndrome / Q000097:blood / Q000235:genetics; D000787:Angina Pectoris / Q000097:blood / Q000235:genetics; D015703:Antigens, CD / Q000097:blood* / Q000235:genetics*; D015415:Biomarkers / Q000097:blood; D002318:Cardiovascular Diseases / Q000097:blood* / Q000235:genetics*; D003324:Coronary Artery Disease / Q000097:blood / Q000235:genetics; D000074283:Endothelial Protein C Receptor; D005260:Female; D006801:Humans; D008297:Male; D020641:Polymorphism, Single Nucleotide; D011956:Receptors, Cell Surface / Q000097:blood* / Q000235:genetics*; D012307:Risk Factors
chemical_list: D015703:Antigens, CD; D015415:Biomarkers; D000074283:Endothelial Protein C Receptor; C478370:PROCR protein, human; D011956:Receptors, Cell Surface