title: Capsofulvesins A-C, cholinesterase inhibitors from Capsosiphon fulvescens.
abstract: Activity-directed isolation of the n-hexane and dichloromethane fractions of Capsosiphon fulvescens resulted in the identification of four new glycolipids (1-3): (2S)-1-O-(6Z,9Z,12Z,15Z-octadecatetraenoyl)-2-O-(4Z,7Z,10Z,13Z-hexadecatetraenoyl)-3-O-β-D-galactopyranosyl glycerol (1, capsofulvesin A), (2S)-l-O-(9Z,12Z,15Z-octadecatrienoyl)-2-O-(10Z,13Z-hexadecadienoyl)-3-O-β-D-galactopyranosyl glycerol (2, capsofulvesin B), (2S)-1-O-(6Z,9Z,12Z,15Z-octadecatetraenoyl)-3-O-β-D-galacatopyranosyl glycerol (3, capsofulvesin C). Compounds 1-6 exhibited acetylcholinesterase (AChE) inhibitory activities with IC(50) values ranging from 50.90 to 82.83 µM, whereas 2-6 showed butyrylcholinesterase (BChE) inhibitory activities with IC(50) values of 114.75-185.55 µM. Although most of the compounds isolated lacked scavenging activity for 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical and peroxynitrite (ONOO(-)), compound 8 showed ONOO(-) scavenging activity with an IC(50) value of 26.23 µg/mL.
authors.affiliation: College of Pharmacy, Catholic University of Daegu, Gyeongbuk 712–702, Republic of Korea.
authors.forename: Zhe
authors.initials: Z
authors.lastname: Fang
authors.forename: Su
authors.initials: S
authors.lastname: Yang Jeong
authors.forename: Hyun
authors.initials: H
authors.lastname: Ah Jung
authors.forename: Jae
authors.initials: J
authors.lastname: Sue Choi
authors.forename: Byung
authors.initials: B
authors.lastname: Sun Min
authors.forename: Mi
authors.initials: M
authors.lastname: Hee Woo
mesh_terms: D000110:Acetylcholinesterase / Q000378:metabolism; D001713:Biphenyl Compounds / Q000378:metabolism; D002091:Butyrylcholinesterase / Q000378:metabolism; D000460:Chlorophyta / Q000737:chemistry*; D002800:Cholinesterase Inhibitors / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D016166:Free Radical Scavengers / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D005609:Free Radicals / Q000378:metabolism; D006017:Glycolipids / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D006801:Humans; D020128:Inhibitory Concentration 50; D030421:Peroxynitrous Acid / Q000378:metabolism; D010851:Picrates / Q000378:metabolism
chemical_list: D001713:Biphenyl Compounds; D002800:Cholinesterase Inhibitors; D016166:Free Radical Scavengers; D005609:Free Radicals; D006017:Glycolipids; D010851:Picrates; D030421:Peroxynitrous Acid; C004931:1,1-diphenyl-2-picrylhydrazyl; D000110:Acetylcholinesterase; D002091:Butyrylcholinesterase