title: Synthesis and biological evaluation of ⁹⁹mTc(CO)₃(His-CB) as a tumor imaging agent.
abstract: The chlorambucil l-histidine conjugate was synthesized and radiolabeled with [(99m)Tc(CO)(3)](+) core to form the (99m)Tc(CO)(3)(His-CB) complex. The radiochemical purity of the complex was over 90%. It had good hydrophilicity and was stable at room temperature. The high initial tumor uptake with certain retention, fast clearance from background, good tumor/non-tumor ratios and satisfactory scintigraphic images highlighted the potential of (99m)Tc(CO)(3)(His-CB) as a tumor imaging agent.
authors.affiliation: Research Center for Applications of Nuclear Technology, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing 100049, People's Republic of China. wangjianjun@ihep.ac.cn
authors.forename: Jianjun
authors.initials: J
authors.lastname: Wang
authors.forename: Jing
authors.initials: J
authors.lastname: Yang
authors.forename: Xiaojiang
authors.initials: X
authors.lastname: Duan
authors.forename: Yanhua
authors.initials: Y
authors.lastname: Zhang
authors.forename: Wenjiang
authors.initials: W
authors.lastname: Yang
authors.forename: Yu
authors.initials: Y
authors.lastname: Liu
mesh_terms: D000818:Animals; D003287:Contrast Media / Q000138:chemical synthesis / Q000493:pharmacokinetics; D051379:Mice; D015394:Molecular Structure; D009374:Neoplasms, Experimental / Q000175:diagnosis*; D015609:Organotechnetium Compounds / Q000138:chemical synthesis / Q000493:pharmacokinetics; D014018:Tissue Distribution
chemical_list: C580967:99mTc(CO)3(His-CB); D003287:Contrast Media; D015609:Organotechnetium Compounds