title: Profiles of tumor-infiltrating lymphocytes in a case of trichilemmal carcinoma with spontaneous regression.
abstract: We describe the case of a 69-year-old Japanese patient with spontaneous regression of trichilemmal carcinoma. We investigated the immunohistochemical profiles of tumor-infiltrating lymphocytes, focusing on cytotoxic granules, granulysin-bearing cells and immunosuppressive cells, such as regulatory T cells and tumor-associated macrophages. Our present study describes some of the possible mechanisms of the self-regression of cutaneous malignant tumors and potential therapies for trichilemmal carcinoma by modifying the tumor microenvironment.
authors.affiliation: Department of Dermatology, Tohoku University Graduate School of Medicine, Sendai, Japan.
authors.forename: Sadanori
authors.initials: S
authors.lastname: Furudate
authors.forename: Taku
authors.initials: T
authors.lastname: Fujimura
authors.forename: Akira
authors.initials: A
authors.lastname: Tsukada
authors.forename: Yukikazu
authors.initials: Y
authors.lastname: Numata
authors.forename: Yumi
authors.initials: Y
authors.lastname: Kambayashi
authors.forename: Setsuya
authors.initials: S
authors.lastname: Aiba
keywords: Granulysin; Spontaneous regression; Trichilemmal carcinoma