title: Clinicopathologic features of brain metastases from gynecologic malignancies: a retrospective study of 139 cases (KCOG-G1001s trial).
abstract: OBJECTIVE
  Although brain metastases from gynecologic malignancies are rare, such cases have been gradually increasing in number. The aim of the present study was to evaluate the clinicopathologic features and prognostic factors of brain metastases from gynecologic malignancies.
  
  
  METHODS
  Retrospective analysis of 139 patients with brain metastases from gynecologic malignancies was carried out as a multi-institutional study. The clinicophathological data of the patients were collected from medical records.
  
  
  RESULTS
  Median survival time of the patients with brain metastases was 12.5 months for the ovarian cancer group, 6.2 months for the corpus cancer group, and 5.0 months for the cervical cancer group; two-year overall survival rates were 19.7%, 6.1%, and 4.8%, respectively. Multivariate analysis revealed ovarian/tubal/peritoneal origin, KPS >70, single brain metastasis, absence of extracranial disease, cranial surgery, cranial radiotherapy, and chemotherapy to be independent favorable prognostic factors associated with overall survival.
  
  
  CONCLUSIONS
  It is considered that aggressive multimodal therapy is warranted in the treatment of brain metastases from gynecologic malignancies in carefully selected patients. The present study may provide a platform for the discussion of management strategies in these rare clinical scenarios.
authors.affiliation: Kansai Clinical Oncology Group, Osaka, Osaka 543-8555, Japan. nasu@oita-u.ac.jp
authors.forename: Kaei
authors.initials: K
authors.lastname: Nasu
authors.forename: Toyomi
authors.initials: T
authors.lastname: Satoh
authors.forename: Shin
authors.initials: S
authors.lastname: Nishio
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Nagai
authors.forename: Kimihiko
authors.initials: K
authors.lastname: Ito
authors.forename: Takeo
authors.initials: T
authors.lastname: Otsuki
authors.forename: Atsushi
authors.initials: A
authors.lastname: Hongo
authors.forename: Yasuyuki
authors.initials: Y
authors.lastname: Hirashima
authors.forename: Tomonori
authors.initials: T
authors.lastname: Ogura
authors.forename: Muneaki
authors.initials: M
authors.lastname: Shimada
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001932:Brain Neoplasms / Q000000981:diagnostic imaging / Q000473:pathology / Q000556:secondary* / Q000628:therapy; D005260:Female; D005833:Genital Neoplasms, Female / Q000000981:diagnostic imaging / Q000473:pathology* / Q000628:therapy; D006801:Humans; D008875:Middle Aged; D009367:Neoplasm Staging; D011859:Radiography; D012189:Retrospective Studies; D015996:Survival Rate