title: Water drinking-related muscle contraction induces the pressor response via mechanoreceptors in conscious rats.
abstract: Water drinking is known to induce the pressor response. The efferent pathway in this response involves sympathoexcitation, because the pressor response was completely abolished by ganglionic blockade or an α(1)-adrenergic antagonist. However, the afferent pathway in this response has not been identified. In the present study, we hypothesized that water itself stimulates the upper digestive tract to induce the pressor response, and/or drinking-related muscle contraction induces the pressor response via mechanoreceptors. To examine this hypothesis, we evaluated the pressor response induced by spontaneous or passive water drinking in conscious rats. Since the baroreflex modulates and obscures the pressor response, the experiments were conducted using rats with sinoaortic denervation. The pressor response was not suppressed by 1) transient oral surface anesthesia using lidocaine, 2) bilateral denervation of the glossopharyngeal nerve and sensory branch of the superior laryngeal nerve, or 3) denervation of the tunica adventitia in the esophagus. However, the pressor response was significantly suppressed (by -52%) by intravenous gadolinium chloride administration. Electrical stimulation of the hypoglossal nerve induced the pressor response, which was significantly suppressed (by -57%) by intravenous gadolinium chloride administration and completely abolished by severing the distal end of this nerve. These results indicate that afferent signals from mechanoreceptors in drinking-related muscles are involved in the water drinking-induced pressor response.
authors.affiliation: Department of Physiology, Gifu University Graduate School of Medicine, Gifu, Japan.
authors.forename: Chikara
authors.initials: C
authors.lastname: Abe
authors.forename: Chihiro
authors.initials: C
authors.lastname: Iwata
authors.forename: Hironobu
authors.initials: H
authors.lastname: Morita
mesh_terms: D063194:Adventitia / Q000187:drug effects / Q000378:metabolism / Q000502:physiology; D000344:Afferent Pathways / Q000187:drug effects / Q000378:metabolism / Q000502:physiology; D000818:Animals; D062186:Arterial Pressure / Q000187:drug effects / Q000502:physiology; D017704:Baroreflex / Q000187:drug effects / Q000502:physiology*; D003243:Consciousness / Q000187:drug effects / Q000502:physiology*; D003714:Denervation / Q000379:methods; D004326:Drinking / Q000502:physiology*; D004558:Electric Stimulation / Q000379:methods; D004947:Esophagus / Q000187:drug effects / Q000378:metabolism / Q000502:physiology; D005682:Gadolinium / Q000494:pharmacology; D005930:Glossopharyngeal Nerve / Q000187:drug effects / Q000378:metabolism / Q000502:physiology; D006339:Heart Rate / Q000187:drug effects / Q000502:physiology; D007823:Laryngeal Nerves / Q000187:drug effects / Q000378:metabolism / Q000502:physiology; D008012:Lidocaine / Q000494:pharmacology; D008297:Male; D008465:Mechanoreceptors / Q000378:metabolism*; D009119:Muscle Contraction / Q000187:drug effects / Q000502:physiology*; D011311:Pressoreceptors / Q000378:metabolism; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D008012:Lidocaine; D005682:Gadolinium; C038958:gadolinium chloride