title: NMR spectroscopy in bioinorganic chemistry.
abstract: Multinuclear and multidimensional nuclear magnetic resonance (NMR) spectroscopy is applied in our groups to gain insights into the role of metal ions for the function and structure of large biomolecules. Specifically, NMR is used i) to investigate how metal ions bind to nucleic acids  and thereby control the folding and structure of RNAs, ii) to characterize how metal ions are able to stabilize modified nucleic acids to be used as potential nanowires, and iii) to characterize the formation, structure, and role of the diverse metal clusters within plant metallothioneins.  In this review we summarize the various NMR experiments applied and the information obtained, demonstrating the important and fascinating part NMR spectroscopy plays in the field of bioinorganic chemistry.
authors.affiliation: University of Zurich Institute of Inorganic Chemistry, Winterthurerstrasse 190, CH-8057 Zürich, Switzerland.
authors.forename: Daniela
authors.initials: D
authors.lastname: Donghi
authors.forename: Silke
authors.initials: S
authors.lastname: Johannsen
authors.forename: Roland K O
authors.initials: RK
authors.lastname: Sigel
authors.forename: Eva
authors.initials: E
authors.lastname: Freisinger
mesh_terms: D015393:Chemistry, Bioinorganic / Q000379:methods; D009682:Magnetic Resonance Spectroscopy / Q000379:methods*; D008668:Metallothionein / Q000737:chemistry*; D008958:Models, Molecular; D009696:Nucleic Acids / Q000737:chemistry*; D016337:RNA, Catalytic / Q000737:chemistry*
chemical_list: D009696:Nucleic Acids; D016337:RNA, Catalytic; D008668:Metallothionein