title: Clinical application of magnetic resonance imaging in preoperative evaluation of endometrial cancer.
abstract: OBJECTIVE
  To investigate the value of magnetic resonance imaging (MRI) in the preoperative assessment of endometrial cancer.
  
  
  METHODS
  Ninety-four patients with histopathologically confirmed endometrial carcinoma were retrospectively enrolled in this study. MRI findings were compared with the pathologic findings in all cases. The depth of myometrial invasion and lymph node metastasis were evaluated by T2 weighted imaging (T2WI) combined with contrast enhancement or diffusion weighted imaging (DWI).
  
  
  RESULTS
  Among these 94 patients,62 had no or superficial myometrial involvement and 32 cases had deep myometrial involvement. Meanwhile, 24 groups of metastatic lymph nodes and 164 groups of non-metastatic lymph nodes were detected. The accuracy, specificity, sensitivity, negative predictive value, and positive predictive value of T2WI combined with contrast enhancement in discriminating no/superficial myometrial involvement from deep myometrial involvement were 88.3%, 90.3%, 84.4%, 91.8%, and 81.8%, whereas those of T2WI combined with DWI were 81.9%, 87.1%, 71.9%, 85.7%, and 74.2%, respectively. The accuracy, specificity, sensitivity, negative predictive value, and positive predictive value of T2WI combined with contrast enhancement in identifying metastatic lymph nodes were 89.4%, 96.8%, 54.5%, 90.9%, and 78.3%, whereas those of T2WI combined with DWI were 91.5%, 95.5%, 72.7%, 94.3%, and 77.4%, respectively.
  
  
  CONCLUSIONS
  T2WI combined with contrast enhancement is superior to T2WI combined with DWI in evaluation of the depth of myometrial invasion. However, DWI is more sensitive in identifying lymph node metastasis than T2WI combined with contrast enhancement.
authors.affiliation: Department of Radiology, PUMC Hospital,CAMS and PUMC, Beijing 100730,China.
authors.forename: Cui
authors.initials: C
authors.lastname: Ren
authors.forename: Hua-dan
authors.initials: HD
authors.lastname: Xue
authors.forename: Shuo
authors.initials: S
authors.lastname: Li
authors.forename: Jie
authors.initials: J
authors.lastname: Zhang
authors.forename: Wei-dong
authors.initials: WD
authors.lastname: Pan
authors.forename: Zhao-yong
authors.initials: ZY
authors.lastname: Sun
authors.forename: Hong-ying
authors.initials: HY
authors.lastname: Fang
authors.forename: Hong-yi
authors.initials: HY
authors.lastname: Sun
authors.forename: Zheng-yu
authors.initials: ZY
authors.lastname: Jin
mesh_terms: D000328:Adult; D000368:Aged; D016889:Endometrial Neoplasms / Q000175:diagnosis* / Q000473:pathology; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008875:Middle Aged; D012189:Retrospective Studies; D012680:Sensitivity and Specificity