title: Efficacy of probing with mitomycin-C in adults with primary acquired nasolacrimal duct obstruction.
abstract: OBJECTIVE
  To evaluate the efficacy and safety of adjunctive mitomycin-c (MMC) during probing in adults with primary nasolacrimal duct (NLD) obstruction.
  
  
  METHODS
  This is a prospective, comparative, randomized interventional study. A total of 40 adult patients with unilateral epiphora caused by primary NLD obstruction were treated and evaluated. Lacrimal probing and irrigation with adjunctive MMC (1 mL of 0.2 mg/mL, once) in cases and only probing in controls were done. At the end of 3 months, subjective improvement in epiphora and patency on syringing were evaluated.
  
  
  RESULTS
  Complete subjective improvement in epiphora was found in 15% of cases as opposed to 0% in controls, at 3 months of follow-up. Moderate improvement was seen in 25% of cases as opposed to 5% of controls. Mild improvement was seen in 25% of cases as opposed to 35% in controls. The overall subjective improvement was seen in 65% of cases as opposed to 40% in controls. On syringing, NLD was patent in 30% of cases as opposed to 10% in controls at 3 months of follow-up, which was not significant.
  
  
  CONCLUSIONS
  Use of intraoperative MMC improves the success of probing to some extent. Being a minimally invasive procedure, it can be tried in patients who refuse or are not systemically fit for undergoing dacryocystorhinostomy.
authors.affiliation: Oculoplastic and Pediatric Ophthalmology Services, Dr. Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi, India. drmanishsinha2k6@rediffmail.com
authors.forename: Manish Kumar
authors.initials: MK
authors.lastname: Sinha
authors.forename: Mandeep S
authors.initials: MS
authors.lastname: Bajaj
authors.forename: Neelam
authors.initials: N
authors.lastname: Pushker
authors.forename: Supriyo
authors.initials: S
authors.lastname: Ghose
authors.forename: Mahesh
authors.initials: M
authors.lastname: Chandra
mesh_terms: D000328:Adult; D000477:Alkylating Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D003608:Dacryocystorhinostomy; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007767:Lacrimal Duct Obstruction / Q000473:pathology; D008297:Male; D008875:Middle Aged; D016685:Mitomycin / Q000008:administration & dosage / Q000627:therapeutic use*; D013508:Ophthalmologic Surgical Procedures / Q000379:methods*; D011446:Prospective Studies; D007507:Therapeutic Irrigation / Q000379:methods; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D000477:Alkylating Agents; D016685:Mitomycin