title: Systemic sclerosis.
abstract: This review updates the clinician on the pathogenesis, differential diagnosis and spectrum of disease  in systemic sclerosis. The wide range of current therapeutic options and  future targeted molecular therapies are also explored.
authors.affiliation: Department of Rheumatology, Salford Royal Hospital, Salford, UK. michael.hughes-6@postgrad.manchester.ac.uk
authors.forename: Michael
authors.initials: M
authors.lastname: Hughes
authors.forename: Ariane
authors.initials: A
authors.lastname: Herrick
mesh_terms: D003937:Diagnosis, Differential; D014943:Global Health; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use*; D015994:Incidence; D012595:Scleroderma, Systemic / Q000175:diagnosis / Q000188:drug therapy / Q000453:epidemiology
chemical_list: D007166:Immunosuppressive Agents