title: Prevalence of peripheral arterial disease in hemodialysis patients.
abstract: BACKGROUND
  The ankle-brachial index (ABI), measurement of carotid artery intima-media thickness (CIMT), and assessment of the thickness of interventricular septum (IVS), are noninvasive methods used to predict subclinical atherosclerosis in hemodialysis patients. This study aimed to determine the prevalence of peripheral arterial disease and to assess the correlations between ABI, CIMT, the thickness of IVS, and blood parameters in hemodialysis patients.
  
  
  METHODS
  The ABI, CIMT, and the thickness of IVS were measured in 50 patients on hemodialysis. Data were collected regarding the levels of calcium, urine nitrogen, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, triglyceride, cholesterol, creatinine, albumin in serum, as well as erythrocyte sedimentation rate. Results. Ten percent of the patients showed a reduced ABI (< 0.9). The mean values for ABI, CIMT, and IVS were 1.09 ± 0.13, 0.68 ± 0.11 mm, and 9.83 ± 1.65 mm, respectively. The levels of calcium, cholesterol, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, and triglyceride in the serum of the patients with normal ABI were significantly higher than in patients with reduced ABI. There was a negative correlation between ABI and levels of serum LDLC (r = -0.29, P = .04) and triglyceride (r = -0.32, P = .02). Conclusions. The prevalence of peripheral arterial disease in the patients with CRF was 10% and it was correlated with several classical risk factors for atherosclerosis, including elevated LDL and cholesterol levels. CIMT and the thickness of IVS showed no apparent association with ABI.
authors.affiliation: Rasul Akram Hospital, Tehran University of Medical Sciences, Tehran, Iran.
authors.forename: Mosadegh
authors.initials: M
authors.lastname: Jabbari
authors.forename: Mitra
authors.initials: M
authors.lastname: Kazemi Jahromi
authors.forename: Nasime
authors.initials: N
authors.lastname: Bahar
authors.forename: Elham Sadat
authors.initials: ES
authors.lastname: Yousefi-Far
authors.forename: Mohsen
authors.initials: M
authors.lastname: Arabi
authors.forename: Nastaran
authors.initials: N
authors.lastname: Asefi
authors.forename: Alireza
authors.initials: A
authors.lastname: Mahmoudian
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D055109:Ankle Brachial Index; D050197:Atherosclerosis / Q000209:etiology; D002118:Calcium / Q000378:metabolism; D059168:Carotid Intima-Media Thickness; D008076:Cholesterol, HDL / Q000378:metabolism; D008078:Cholesterol, LDL / Q000378:metabolism; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D007676:Kidney Failure, Chronic / Q000097:blood / Q000150:complications* / Q000628:therapy; D008297:Male; D008875:Middle Aged; D058729:Peripheral Arterial Disease / Q000097:blood / Q000453:epidemiology / Q000209:etiology*; D015995:Prevalence; D006435:Renal Dialysis / Q000009:adverse effects*; D014280:Triglycerides / Q000378:metabolism; D055815:Young Adult
chemical_list: D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D014280:Triglycerides; D002118:Calcium