title: Androgen receptor in human health: a potential therapeutic target.
abstract: Androgen is a key for the activation of Androgen Receptor (AR) in most of the disease conditions, however androgen-independent activation of AR is also found in aggressive type human malignancies. An intense search for the inhibitors of AR is underway to cure AR-dependent diseases. In addition to targeting various components of AR signaling pathway, compounds which directly target AR are under preclinical and clinical investigation. Various In vitro and preclinical animal studies suggest that different natural compounds have potential to act against AR. Some natural compounds have been found to be pharmacologically effective against AR irrespective of varying routs of administration viz; oral, intra-peritoneal and intravenous. This mini-review summarizes the studies conducted with different natural agents in determining their pharmacological utility against AR signaling.
authors.affiliation: Molecular Chemoprevention and Therapeutics, The Hormel Institute, University of Minnesota, Austin, MN 55912, USA.
authors.forename: Hifzur Rahman
authors.initials: HR
authors.lastname: Siddique
authors.forename: Sanjeev
authors.initials: S
authors.lastname: Nanda
authors.forename: Aijaz
authors.initials: A
authors.lastname: Parray
authors.forename: Mohammad
authors.initials: M
authors.lastname: Saleem
mesh_terms: D059002:Androgen Receptor Antagonists / Q000008:administration & dosage* / Q000378:metabolism; D000728:Androgens / Q000378:metabolism; D000818:Animals; D016503:Drug Delivery Systems / Q000379:methods / Q000639:trends*; D006304:Health Status; D006801:Humans; D008297:Male; D009376:Neoplasms, Hormone-Dependent / Q000188:drug therapy* / Q000378:metabolism; D011471:Prostatic Neoplasms / Q000188:drug therapy / Q000378:metabolism; D011944:Receptors, Androgen / Q000378:metabolism*; D015398:Signal Transduction / Q000187:drug effects / Q000502:physiology
chemical_list: D059002:Androgen Receptor Antagonists; D000728:Androgens; D011944:Receptors, Androgen