title: Autologous adipose-tissue derived regenerative cells for the treatment of complex cryptoglandular fistula-in-ano: a report of three cases.
abstract: The treatment of complex fistulae-in-ano is challenging and often includes a number of operations due to high rates of recurrence. We report the successful treatment of three consecutive patients with long-standing cryptoglandular fistula-in-ano with a novel combination of mucosal advancement flap and adipose-tissue derived regenerative cells (ADRCs) from the stromal vascular fraction (SVF) obtained from a simple lipoaspiration procedure, using Celution technology. There was no operative morbidity; one patient who had a colostomy for faecal diversion has since undergone restoration of bowel continuity. All thee fistulae remain healed at 2-3-year follow-up. Lipofilling of cryptoglandular fistulae-in-ano with ADRC-enhanced lipofilling appears feasible and safe, and may add to the range of procedures that can be used to treat this difficult problem.
authors.affiliation: Department of Colorectal Surgery, University Hospital North Tees, Stockton on Tees, UK. DWBorowski@AOL.com
authors.forename: David W
authors.initials: DW
authors.lastname: Borowski
authors.forename: Talvinder S
authors.initials: TS
authors.lastname: Gill
authors.forename: Anil K
authors.initials: AK
authors.lastname: Agarwal
authors.forename: Pudhupalayam
authors.initials: P
authors.lastname: Bhaskar
mesh_terms: D000273:Adipose Tissue / Q000166:cytology*; D053687:Adult Stem Cells; D001003:Anal Canal / Q000601:surgery*; D042783:Endothelial Cells; D005260:Female; D006801:Humans; D007267:Injections; D007413:Intestinal Mucosa / Q000601:surgery; D015187:Lipectomy; D008264:Macrophages; D008297:Male; D008875:Middle Aged; D032389:Myocytes, Smooth Muscle; D012003:Rectal Fistula / Q000601:surgery / Q000628:therapy*; D012038:Regeneration; D013524:Surgical Flaps