title: An antitumor component from Fomitiporia ellipsoidea.
abstract: A natural furan derivative was isolated from the methanolic extract of the fruit bodies of Fomitiporia ellipsoidea. Its chemical structure was elucidated as methyl 3,5-dioxo- 1,3,5,7-tetrahydrobenzo[1,2-c:4,5-c']difuran-4-carboxylate by means of extensive NMR and MS data analysis, and named as fomitiporiaester A (1). Compound 1 showed significant antitumor activity to hepatoma H(22) in vivo, and the inhibition rates were 42.94%, 49.17%, and 58.15% at concentrations of 5, 10, and 20 mg/kg, respectively. Compound 1 showed weak cytotoxic activities against the human hepatoblastoma (HepG-2) and human oophoroma (Skov 3) cell lines with IC(50) values of more than 100 μM.
authors.affiliation: Engineering Research Centre of Edible and Medicinal Fungi, Ministry of Education, Jilin Agricultural University, Changchun, Jilin 130118, PR China.
authors.forename: Zan
authors.initials: Z
authors.lastname: Lifeng
authors.forename: Bao
authors.initials: B
authors.lastname: Haiying
authors.forename: Tolgor
authors.initials: T
authors.lastname: Bau
authors.forename: Hanbin
authors.initials: H
authors.lastname: Liu
authors.forename: Baokai
authors.initials: B
authors.lastname: Cui
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry / Q000378:metabolism* / Q000494:pharmacology; D001487:Basidiomycota / Q000737:chemistry / Q000254:growth & development / Q000378:metabolism*; D045744:Cell Line, Tumor; D004354:Drug Screening Assays, Antitumor; D005260:Female; D048690:Fruiting Bodies, Fungal / Q000737:chemistry / Q000254:growth & development / Q000378:metabolism; D006801:Humans; D051379:Mice; D015394:Molecular Structure; D009369:Neoplasms / Q000188:drug therapy
chemical_list: D000970:Antineoplastic Agents