title: [Successful use of C1 esterase inhibitor in capillary leak syndrome].
abstract: This article reports the successful use of C1 esterase inhibitor in the treatment of capillary leak syndrome. The coincidence of exposure to latex during surgery and medication with ramipril led to prolonged shock complicated by secondary hyperfibrinolysis, capillary leak syndrome and multiple organ failure. Initial treatment according to relevant guidelines failed to stabilize the condition. Treatment was only successful after administration of 1,500 IU of human C1 esterase inhibitor.
authors.affiliation: Klinik für Anästhesiologie und Intensivmedizin, HELIOS-Kliniken Schwerin, Schwerin, Deutschland. ronald.seidel@helios-kliniken.de
authors.forename: R
authors.initials: R
authors.lastname: Seidel
mesh_terms: D000758:Anesthesia; D000806:Angiotensin-Converting Enzyme Inhibitors / Q000009:adverse effects / Q000627:therapeutic use; D001014:Aortic Aneurysm / Q000601:surgery; D019559:Capillary Leak Syndrome / Q000188:drug therapy*; D050718:Complement C1 Inhibitor Protein / Q000627:therapeutic use*; D004211:Disseminated Intravascular Coagulation / Q000150:complications / Q000628:therapy; D004342:Drug Hypersensitivity / Q000188:drug therapy; D006801:Humans; D007431:Intraoperative Complications / Q000628:therapy; D020315:Latex Hypersensitivity / Q000150:complications / Q000628:therapy; D008297:Male; D008875:Middle Aged; D009102:Multiple Organ Failure / Q000188:drug therapy; D017257:Ramipril / Q000009:adverse effects / Q000627:therapeutic use; D012769:Shock / Q000188:drug therapy
chemical_list: D000806:Angiotensin-Converting Enzyme Inhibitors; D050718:Complement C1 Inhibitor Protein; D017257:Ramipril