title: Salvage rates of compromised free flap breast reconstruction after recurrent thrombosis.
abstract: BACKGROUND
  Microvascular complications after free flap breast reconstruction are devastating problems that increase patient morbidity and potentially lead to flap loss. Yet, there is a dearth of literature about rates of free flap salvage after recurrent vascular thromboses.
  
  
  METHODS
  A retrospective review of all patients undergoing microvascular breast reconstruction at UCLA Medical Center from January 1991 to June 2010 was conducted. The incidence of microvascular thrombosis was evaluated and rates of flap salvage and complications were specifically analyzed after a single microvascular revision (Single Event), 2 or more revisions (Multiple Event), and delayed presentation (>2 days) with attempted salvage (Delayed Event).
  
  
  RESULTS
  During the study period, 2094 free flap breast reconstructions were evaluated. Of these, 75 (3.6%) flaps suffered a microvascular complication and 16 (0.76%) flaps were lost. The overall salvage rate was 78.7% (59/75) with the highest salvage rate of 95.9% (47/49) for Single Events. Multiple Events had a salvage rate of 53.3% (8/15), whereas Delayed Events had a salvage rate of 27.3% (3/11). The salvage rate decreased with repeated microvascular events (P < 0.01). In the Multiple Event group, vascular conversion (alternate recipient vessel) correlated with improved flap salvage (87.5%), whereas the lack thereof was associated with flap loss (P < 0.001).
  
  
  CONCLUSIONS
  The salvage rate of free flap breast reconstruction diminishes dramatically with recurrent microvascular complications, but can be improved with vascular conversion. The salvage rate in cases of delayed presentation is even worse confirming the need for vigilant postoperative monitoring and aggressive intervention in the setting of flap compromise.
authors.affiliation: UCLA Division of Plastic and Reconstructive Surgery, Los Angeles, CA 90095, USA.
authors.forename: Eric I
authors.initials: EI
authors.lastname: Chang
authors.forename: Brian T
authors.initials: BT
authors.lastname: Carlsen
authors.forename: Jaco H
authors.initials: JH
authors.lastname: Festekjian
authors.forename: Andrew L
authors.initials: AL
authors.lastname: Da Lio
authors.forename: Christopher A
authors.initials: CA
authors.lastname: Crisera
mesh_terms: D058752:Free Tissue Flaps / Q000098:blood supply; D006085:Graft Survival; D006801:Humans; D016462:Mammaplasty; D011183:Postoperative Complications / Q000628:therapy; D012008:Recurrence; D012189:Retrospective Studies; D020246:Venous Thrombosis / Q000209:etiology / Q000628:therapy*