title: Double-effector nanoparticles: a synergistic approach to apoptotic hyperthermia.
abstract: Highly efficient apoptotic hyperthermia is achieved using a double-effector nanoparticle that can generate reactive oxygen species (ROS) and heat. ROS render cancer cells more susceptible to subsequent heat treatment, which remarkably increases the degree of apoptotic cell death. Xenograft tumors (100 mm(3)) in mice are completely eliminated within 8 days after a single mild magnetic hyperthermia treatment at 43 °C for 30 min.
authors.affiliation: Department of Chemistry, Yonsei University, Seoul 120-749, Korea.
authors.forename: Dongwon
authors.initials: D
authors.lastname: Yoo
authors.forename: Heeyeong
authors.initials: H
authors.lastname: Jeong
authors.forename: Christian
authors.initials: C
authors.lastname: Preihs
authors.forename: Jin-sil
authors.initials: JS
authors.lastname: Choi
authors.forename: Tae-Hyun
authors.initials: TH
authors.lastname: Shin
authors.forename: Jonathan L
authors.initials: JL
authors.lastname: Sessler
authors.forename: Jinwoo
authors.initials: J
authors.lastname: Cheon
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry / Q000627:therapeutic use / Q000633:toxicity; D017209:Apoptosis / Q000187:drug effects*; D045744:Cell Line, Tumor; D006801:Humans; D006979:Hyperthermia, Induced; D060526:Magnetic Fields; D053768:Metal Nanoparticles / Q000737:chemistry / Q000627:therapeutic use / Q000633:toxicity*; D008665:Metalloporphyrins / Q000737:chemistry / Q000627:therapeutic use / Q000633:toxicity; D051379:Mice; D009369:Neoplasms / Q000188:drug therapy; D017382:Reactive Oxygen Species / Q000378:metabolism; D013696:Temperature; D014183:Transplantation, Heterologous
chemical_list: D000970:Antineoplastic Agents; D008665:Metalloporphyrins; D017382:Reactive Oxygen Species; C437683:motexafin gadolinium