title: Wx/ae double-mutant brown rice prevents the rise in plasma lipid and glucose levels in mice.
abstract: A wx/ae double-mutant rice is generated by crossing waxy mutant and amylose-extender mutant in rice. Wx/ae brown rice contains highly beneficial nutrients for lipid and glucose metabolism, including resistant starch, dietary fiber, and γ-oryzanol, when compared to Koshihikari brown rice, the non-waxy japonica cultivar. To examine the effects of wx/ae brown rice on glucose and lipid metabolism, type 2 diabetic NSY/Hos mice were fed a high-fat diet containing 25% of wx/ae brown rice or Koshihikari brown rice for 10 weeks. The plasma total cholesterol, non-high-density lipoprotein cholesterol, triglyceride, and non-esterified fatty acid levels of the wx/ae group were significantly lower than those of the Koshihikari group. Moreover, the fasting blood glucose level and pathological score of glycosuria of the wx/ae group were also significantly lower than those of the Koshihikari group. These results indicate that wx/ae brown rice has the potential to prevent the rise in plasma lipid and glucose levels.
authors.affiliation: Department of Food Science, Ishikawa Prefectural University, 1-308 Suematsu, Nonoichi, Ishikawa 921-8836, Japan. kmatsu@ishikawa-pu.ac.jp
authors.forename: Kenji
authors.initials: K
authors.lastname: Matsumoto
authors.forename: Masashi
authors.initials: M
authors.lastname: Maekawa
authors.forename: Makoto
authors.initials: M
authors.lastname: Nakaya
authors.forename: Hatsuho
authors.initials: H
authors.lastname: Takemitsu
authors.forename: Hikaru
authors.initials: H
authors.lastname: Satoh
authors.forename: Shinichi
authors.initials: S
authors.lastname: Kitamura
mesh_terms: D015061:1,4-alpha-Glucan Branching Enzyme / Q000235:genetics*; D000818:Animals; D001786:Blood Glucose / Q000378:metabolism*; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000209:etiology / Q000378:metabolism / Q000517:prevention & control; D059305:Diet, High-Fat / Q000009:adverse effects; D005243:Feces; D005786:Gene Expression Regulation; D008055:Lipids / Q000097:blood*; D008099:Liver / Q000378:metabolism; D008297:Male; D051379:Mice; D009154:Mutation; D012275:Oryza / Q000201:enzymology / Q000235:genetics*; D010940:Plant Proteins / Q000235:genetics*; D013214:Starch Synthase / Q000235:genetics*
chemical_list: D001786:Blood Glucose; D008055:Lipids; D010940:Plant Proteins; C060756:waxy protein, plant; D015061:1,4-alpha-Glucan Branching Enzyme; C116400:starch-branching enzyme IIb; D013214:Starch Synthase