title: Expression of costimulatory molecule B7-H4 in human malignant tumors.
abstract: Costimulatory molecule B7-H4, a member of the B7 family, negatively regulates the immune response of T cells through inhibiting their proliferation, cytokine production and cell cycle. The overexpression of B7-H4 plays an important role in initiation, progression and regression of tumors by promoting malignant transformation of epithelial cells and protecting epithelial cells from anoikis. B7-H4 expression in malignant tumors is useful for clinical diagnosis, and may provide a novel molecular target for cancer treatment.
authors.affiliation: Department of Tumor Biological Treatment, The Third Affiliated Hospital of Soochow University, Changzhou, China.
authors.forename: Xiao
authors.initials: X
authors.lastname: Zheng
authors.forename: Xiao-Dong
authors.initials: XD
authors.lastname: Li
authors.forename: Chang-Ping
authors.initials: CP
authors.lastname: Wu
authors.forename: Bin-Feng
authors.initials: BF
authors.lastname: Lu
authors.forename: Jing-Ting
authors.initials: JT
authors.lastname: Jiang
mesh_terms: D015415:Biomarkers / Q000378:metabolism; D006801:Humans; D008954:Models, Biological; D009363:Neoplasm Proteins / Q000378:metabolism*; D009369:Neoplasms / Q000378:metabolism*; D060907:V-Set Domain-Containing T-Cell Activation Inhibitor 1 / Q000378:metabolism*
chemical_list: D015415:Biomarkers; D009363:Neoplasm Proteins; D060907:V-Set Domain-Containing T-Cell Activation Inhibitor 1; C475826:VTCN1 protein, human