title: Epigenetic mechanisms regulating learning and long-term memory.
abstract: A balance between rapid, short lived, neuronal responses and prolonged ones fulfill the biochemical and cellular requirements for creating a molecular memory. I provide an overview of epigenetic mechanisms in the brain and discuss their impact on synaptic plasticity, cognitive functions, and discuss a recent example of how they can contribute to neurodegeneration and the cognitive decline associated with Alzheimer's disease.
authors.affiliation: Inova Neuroscience Institute, Department of Neurosciences, Inova Health System, 3289 Woodburn Road, Suite 210B, Annandale, VA 22003, United States. robert.lipsky@inova.org
authors.forename: Robert H
authors.initials: RH
authors.lastname: Lipsky
mesh_terms: D000818:Animals; D001921:Brain / Q000502:physiology; D019175:DNA Methylation; D044127:Epigenesis, Genetic; D006657:Histones / Q000378:metabolism; D006801:Humans; D007858:Learning / Q000502:physiology*; D057567:Memory, Long-Term / Q000502:physiology*; D035683:MicroRNAs; D009473:Neuronal Plasticity
chemical_list: D006657:Histones; D035683:MicroRNAs
keywords: DNA methylation; Epigenetics; Hippocampus; Histone; Histone methylation; Learning; Memory; MicroRNA