title: Teratology studies in the mouse.
abstract: The rat is the routine species of choice as the rodent model for regulatory safety testing of xenobiotics such as medicinal products, food additives, and other chemicals. However, the rat is not always suitable for pharmacological, toxicological, immunogenic, pharmacokinetic, or even practical reasons. Under such circumstances, the mouse offers an alternative for finding a suitable rodent model acceptable to the regulatory authorities. Since all essential routes of administration are possible, the short reproductive cycle and large litter size of the mouse make it a species well adapted for use in teratology studies. Given that good quality animals, including virgin mated females, can be acquired relatively easily and inexpensively, the mouse has been used in reproductive toxicity studies for decades and study protocols are well established.
authors.affiliation: Ricerca Biosciences, Saint-Germain sur l'Arbresle, France. Edward.marsden@ricerca.com
authors.forename: Edward
authors.initials: E
authors.lastname: Marsden
authors.forename: Mariline
authors.initials: M
authors.lastname: Leroy
mesh_terms: D000822:Animal Husbandry; D000818:Animals; D001344:Autopsy; D002585:Cesarean Section; D005260:Female; D005333:Fetus / Q000002:abnormalities / Q000187:drug effects / Q000196:embryology / Q000473:pathology; D008297:Male; D051379:Mice; D010599:Pharmacokinetics; D011247:Pregnancy; D018600:Teratology / Q000379:methods*; D018675:Toxicity Tests / Q000379:methods*