title: EcoCyc: fusing model organism databases with systems biology.
abstract: EcoCyc (http://EcoCyc.org) is a model organism database built on the genome sequence of Escherichia coli K-12 MG1655. Expert manual curation of the functions of individual E. coli gene products in EcoCyc has been based on information found in the experimental literature for E. coli K-12-derived strains. Updates to EcoCyc content continue to improve the comprehensive picture of E. coli biology. The utility of EcoCyc is enhanced by new tools available on the EcoCyc web site, and the development of EcoCyc as a teaching tool is increasing the impact of the knowledge collected in EcoCyc.
authors.affiliation: SRI International, 333 Ravenswood Avenue, Menlo Park, CA 94025, USA. keseler@ai.sri.com
authors.forename: Ingrid M
authors.initials: IM
authors.lastname: Keseler
authors.forename: Amanda
authors.initials: A
authors.lastname: Mackie
authors.forename: Martin
authors.initials: M
authors.lastname: Peralta-Gil
authors.forename: Alberto
authors.initials: A
authors.lastname: Santos-Zavaleta
authors.forename: Socorro
authors.initials: S
authors.lastname: Gama-Castro
authors.forename: César
authors.initials: C
authors.lastname: Bonavides-Martínez
authors.forename: Carol
authors.initials: C
authors.lastname: Fulcher
authors.forename: Araceli M
authors.initials: AM
authors.lastname: Huerta
authors.forename: Anamika
authors.initials: A
authors.lastname: Kothari
authors.forename: Markus
authors.initials: M
authors.lastname: Krummenacker
authors.forename: Mario
authors.initials: M
authors.lastname: Latendresse
authors.forename: Luis
authors.initials: L
authors.lastname: Muñiz-Rascado
authors.forename: Quang
authors.initials: Q
authors.lastname: Ong
authors.forename: Suzanne
authors.initials: S
authors.lastname: Paley
authors.forename: Imke
authors.initials: I
authors.lastname: Schröder
authors.forename: Alexander G
authors.initials: AG
authors.lastname: Shearer
authors.forename: Pallavi
authors.initials: P
authors.lastname: Subhraveti
authors.forename: Mike
authors.initials: M
authors.lastname: Travers
authors.forename: Deepika
authors.initials: D
authors.lastname: Weerasinghe
authors.forename: Verena
authors.initials: V
authors.lastname: Weiss
authors.forename: Julio
authors.initials: J
authors.lastname: Collado-Vides
authors.forename: Robert P
authors.initials: RP
authors.lastname: Gunsalus
authors.forename: Ian
authors.initials: I
authors.lastname: Paulsen
authors.forename: Peter D
authors.initials: PD
authors.lastname: Karp
mesh_terms: D001665:Binding Sites; D030541:Databases, Genetic; D048168:Escherichia coli K12 / Q000235:genetics* / Q000378:metabolism; D029968:Escherichia coli Proteins / Q000145:classification / Q000378:metabolism; D015964:Gene Expression Regulation, Bacterial; D020407:Internet; D026901:Membrane Transport Proteins / Q000145:classification / Q000378:metabolism; D008957:Models, Genetic; D058977:Molecular Sequence Annotation; D010641:Phenotype; D056510:Position-Specific Scoring Matrices; D011401:Promoter Regions, Genetic; D049490:Systems Biology; D014157:Transcription Factors / Q000378:metabolism; D014158:Transcription, Genetic
chemical_list: D029968:Escherichia coli Proteins; D026901:Membrane Transport Proteins; D014157:Transcription Factors