title: Patients' willingness to participate in a breast cancer biobank at screening mammogram.
abstract: To characterize patients' willingness to donate a biospecimen for future research as part of a breast cancer-related biobank involving a general screening population. We performed a prospective cross-sectional study of 4,217 women aged 21-89 years presenting to our facilities for screening mammogram between December 2010 and October 2011. This HIPAA-compliant study was approved by our institutional review board. We collected data on patients' interest in and actual donation of a biospecimen, motivators and barriers to donating, demographic information, and personal breast cancer risk factors. A multivariate logistic regression analysis was performed to identify patient-level characteristics associated with an increased likelihood to donate. Mean patient age was 57.8 years (SD 11.1 years). While 66.0 % (2,785/4,217) of patients were willing to donate blood or saliva during their visit, only 56.4 % (2,378/4,217) actually donated. Women with a college education (OR = 1.27, p = 0.003), older age (OR = 1.02, p < 0.001), previous breast biopsy (OR = 1.23, p = 0.012), family history of breast cancer (OR = 1.23, p = 0.004), or a comorbidity (OR = 1.22, p = 0.014) were more likely to donate. Asian-American women were significantly less likely to donate (OR = 0.74, p = 0.005). The major reason for donating was to help all future patients (42.3 %) and the major reason for declining donation was privacy concerns (22.3 %). A large proportion of women participating in a breast cancer screening registry are willing to donate blood or saliva to a biobank. Among minority participants, Asian-American women are less likely to donate and further qualitative research is required to identify novel active recruitment strategies to insure their involvement.
authors.affiliation: Department of Radiology, University of Washington School of Medicine, 825 Eastlake Avenue East, G3-200, Seattle, WA 98109-1023, USA. stophlee@uw.edu
authors.forename: Christoph I
authors.initials: CI
authors.lastname: Lee
authors.forename: Lawrence W
authors.initials: LW
authors.lastname: Bassett
authors.forename: Mei
authors.initials: M
authors.lastname: Leng
authors.forename: Sally L
authors.initials: SL
authors.lastname: Maliski
authors.forename: Bryan B
authors.initials: BB
authors.lastname: Pezeshki
authors.forename: Colin J
authors.initials: CJ
authors.lastname: Wells
authors.forename: Carol M
authors.initials: CM
authors.lastname: Mangione
authors.forename: Arash
authors.initials: A
authors.lastname: Naeim
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D018070:Biological Specimen Banks / Q000706:statistics & numerical data; D001943:Breast Neoplasms / Q000175:diagnosis* / Q000208:ethnology / Q000523:psychology; D003430:Cross-Sectional Studies; D004522:Educational Status; D005260:Female; D007722:Health Knowledge, Attitudes, Practice; D006801:Humans; D008327:Mammography; D008875:Middle Aged; D015999:Multivariate Analysis; D018907:Privacy; D055815:Young Adult