title: Microwave assisted solid phase synthesis of highly functionalized N-alkylated oligobenzamide α-helix mimetics.
abstract: Protein-protein interactions (PPIs) mediate cellular pathways and are implicated in numerous aberrant conditions. α-Helix mimetics-small molecules that reproduce the spatial projection of key residues from an α-helix involved in a PPI-are attractive generic templates for development of screening libraries, however library syntheses of α-helix mimetics with diverse functionality are less established. This manuscript describes the automated, microwave assisted solid phase synthesis based on one such scaffold; an N-alkylated oligobenzamide.
authors.affiliation: School of Chemistry, University of Leeds, Woodhouse Lane, Leeds LS2 9JT, UK.
authors.forename: Kérya
authors.initials: K
authors.lastname: Long
authors.forename: Thomas A
authors.initials: TA
authors.lastname: Edwards
authors.forename: Andrew J
authors.initials: AJ
authors.lastname: Wilson
mesh_terms: D000478:Alkylation; D001549:Benzamides / Q000737:chemistry*; D032701:Biomimetics; D008872:Microwaves; D008958:Models, Molecular; D017433:Protein Structure, Secondary; D054852:Small Molecule Libraries / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D060327:Solid-Phase Synthesis Techniques
chemical_list: D001549:Benzamides; D054852:Small Molecule Libraries; C037689:benzamide