title: [Correlation of the expression of NF-κB p65 and hepatic fibrosis in hepatitis patients].
abstract: OBJECTIVE
  To explore the relationship between the expression of NF-κB p65 and hepatic fibrosis in chronic hepatitis B (CHB) patients.
  
  
  METHODS
  Sixty CHB patients with hepatic fibrosis underwent liver biopsy to determine the stages of liver fibrosis (S0-S4). The distribution and expression of collagens I, III and NF-κB p65 in different stages of fibrosis in liver tissue were observed by immunohistochemistry and the results analyzed statistically.
  
  
  RESULTS
  The expression of NF-κB p65 was positively correlated with the stage of hepatic fibrosis. That was S4 > S3 > S2 > S1 (S0) (P < 0.01). And it was also positively correlated with the expression of collagens I and III (P < 0.01).
  
  
  CONCLUSIONS
  The elevated expression of NF-κB p65 is closely associated with the occurrence and development of hepatic fibrosis. Its mechanism is probably related with the increased secretion of collagens I and III after the activation of hepatic stellate cell.
authors.affiliation: Department of Infectious Diseases, First Affiliated Hospital, Xinxiang Medical University, Henan 453100, China.
authors.forename: Wei-wei
authors.initials: WW
authors.lastname: Li
authors.forename: Quan-chu
authors.initials: QC
authors.lastname: Wang
authors.forename: Xin-wen
authors.initials: XW
authors.lastname: Song
authors.forename: Bao-sheng
authors.initials: BS
authors.lastname: Shen
authors.forename: Xiao-lin
authors.initials: XL
authors.lastname: Geng
authors.forename: Li-juan
authors.initials: LJ
authors.lastname: Hou
mesh_terms: D000293:Adolescent; D000328:Adult; D024042:Collagen Type I / Q000096:biosynthesis; D024061:Collagen Type III / Q000096:biosynthesis; D005260:Female; D019694:Hepatitis B, Chronic / Q000378:metabolism* / Q000473:pathology; D006801:Humans; D008103:Liver Cirrhosis / Q000378:metabolism* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D051996:Transcription Factor RelA / Q000378:metabolism*; D055815:Young Adult
chemical_list: D024042:Collagen Type I; D024061:Collagen Type III; C498143:RELA protein, human; D051996:Transcription Factor RelA