title: [Experimental study of osseointegration of nHA/BG coating and Bio-Oss in implant defects].
abstract: OBJECTIVE
  To evaluate bone regeneration in defects at titanium implants with nHA/BG coating in conjunction with Bio-Oss.
  
  
  METHODS
  Four mandibular premolars were extracted in 6 Beagle dogs. After 3 months, buccal dehiscence-type defects (2.25 mm×3 mm×4 mm) were surgically created following implant site. The three treatment modalities were randomly allocated: nHA/BG implant/Bio-Oss, nHA/BG implant/blood clot, and mHA implant/Bio-Oss. After 8 and 16 weeks, the dogs were sacrificed respectively. A histomorphometric analysis was performed. The data was analyzed with SPSS 13.0 software package for Student's t test and ANOVA.
  
  
  RESULTS
  At 8- and 16-week, nHA/BG implant group revealed comparable mean BIC (30% to 18% versus 61% to 53%). However, mHA implant/Bio-Oss group revealed significantly lower mean BIC (21% versus 46%) values than nHA/BG implant/Bio-Oss group.A significant difference was observed for the mean BIC and RA values at 8-week between nHA/BG implant/Bio-Oss group and mHA implant/Bio-Oss group.
  
  
  CONCLUSIONS
  It is concluded that the application of Bio-Oss graft did not seem to interfere with the nHA/BG coating activity, but ensured a stabilization of the newly formed bone for defects.
authors.affiliation: Department of Prosthodontics, Ninth People's Hospital, College of Stomatology, Shanghai Jiao Tong University School of Medicine, Shanghai 200011, China. fay13706756211@163.com
authors.forename: Fei
authors.initials: F
authors.lastname: Sun
authors.forename: Ting-ting
authors.initials: TT
authors.lastname: Lin
authors.forename: Xiao-ye
authors.initials: XY
authors.lastname: Yuan
authors.forename: Shao-xian
authors.initials: SX
authors.lastname: Zeng
authors.forename: Rui-lin
authors.initials: RL
authors.lastname: DU
authors.forename: Er-yi
authors.initials: EY
authors.lastname: Lu
mesh_terms: D000818:Animals; D001861:Bone Regeneration; D018786:Bone Substitutes; D003758:Dental Implantation, Endosseous; D015921:Dental Implants; D004285:Dogs; D008903:Minerals; D016348:Osseointegration; D014025:Titanium
chemical_list: C077540:Bio-Oss; D018786:Bone Substitutes; D015921:Dental Implants; D008903:Minerals; D014025:Titanium