title: Optimal control of an influenza model with seasonal forcing and age-dependent transmission rates.
abstract: This study considers an optimal intervention strategy for influenza outbreaks. Variations in the SEIAR model are considered to include seasonal forcing and age structure, and control strategies include vaccination, antiviral treatment, and social distancing such as school closures. We formulate an optimal control problem by minimizing the incidence of influenza outbreaks while considering intervention costs. We examine the effects of delays in vaccine production, seasonal forcing, and age-dependent transmission rates on the optimal control and suggest some optimal strategies through numerical simulations.
authors.affiliation: Department of Computational Science and Engineering, Yonsei University, Shinchondong, Seodaemungu, Seoul 120-749, Republic of Korea. ezhyun@yonsei.ac.kr
authors.forename: Jeehyun
authors.initials: J
authors.lastname: Lee
authors.forename: Jungeun
authors.initials: J
authors.lastname: Kim
authors.forename: Hee-Dae
authors.initials: HD
authors.lastname: Kwon
mesh_terms: D000367:Age Factors; D000375:Aging / Q000502:physiology*; D050936:Basic Reproduction Number; D003198:Computer Simulation; D006801:Humans; D007251:Influenza, Human / Q000453:epidemiology / Q000276:immunology / Q000517:prevention & control* / Q000635:transmission*; D008954:Models, Biological; D012621:Seasons; D014612:Vaccines / Q000276:immunology
chemical_list: D014612:Vaccines