title: The rs9939609 gene variant in FTO modified the metabolic response of weight loss after a 3-month intervention with a hypocaloric diet.
abstract: BACKGROUND
  Common polymorphisms in the fat mass and obesity associated gene (FTO) have been linked to obesity in some populations. Nevertheless, the role of FTO variants on body weight response after dietary intervention remains equivocal.
  
  
  OBJECTIVE
  We decided to analyze the effects of the rs9939609 FTO gene polymorphism on body weight changes and metabolic parameters after 3 months of a hypocaloric diet.
  
  
  METHODS
  Before and after 3 months on a low-fat hypocaloric diet, a white population of 106 subjects with obesity was analyzed.
  
  
  RESULTS
  Of the study subjects, 35 (33%) had the genotype TT and 71 (67%) had the next genotypes; TA (46 study subjects, 43.4%) or AA (25 study subjects, 23.6%). After dietary treatment and in TT group, weight, waist circumference, total cholesterol, LDL-cholesterol, insulin, and homeostasis model assessment decreases were less than subjects carrying the A allele [-3.1 (3.6) vs -2.4 (4.1) kg: P < 0.05], waist circumference [-5.4 (6.4) vs -2.6 (4.8) cm; P < 0.05], total cholesterol [-12.3 (35.3) vs -6.4 (4.7) mg/dL; P < 0.05], LDL-cholesterol [-22.3 (30.5) vs -10.7 (30.5) mg/dL; P < 0.05], insulin [-1.89 (5.5) vs +0.94 (8.2) mUI/L; P < 0.05], and homeostasis model assessment [-0.46 (1.11) vs -0.01 (2.4); P < 0.05].
  
  
  CONCLUSIONS
  Our study confirmed a higher weight loss in A carriers of FTO rs9939609 polymorphism than in TT genotype study subjects.
authors.affiliation: Center of Investigation of Endocrinology and Nutrition, Medicine School and Unit of Investigation, Hospital Rio Hortega, University of Valladolid, Valladolid, Spain. dadluis@yahoo.es
authors.forename: Daniel Antonio
authors.initials: DA
authors.lastname: de Luis
authors.forename: Rocío
authors.initials: R
authors.lastname: Aller
authors.forename: Rosa
authors.initials: R
authors.lastname: Conde
authors.forename: Olatz
authors.initials: O
authors.lastname: Izaola
authors.forename: Manuel
authors.initials: M
authors.lastname: Gonzalez Sagrado
authors.forename: Javier
authors.initials: J
authors.lastname: Castrodeza Sanz
mesh_terms: D000328:Adult; D000368:Aged; D000071516:Alpha-Ketoglutarate-Dependent Dioxygenase FTO; D031204:Caloric Restriction / Q000379:methods; D018752:Diet, Fat-Restricted / Q000379:methods; D004038:Diet, Reducing / Q000379:methods; D005260:Female; D014644:Genetic Variation / Q000235:genetics*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000178:diet therapy* / Q000235:genetics*; D011446:Prospective Studies; D011506:Proteins / Q000235:genetics*; D013997:Time Factors; D015431:Weight Loss / Q000235:genetics*
chemical_list: D011506:Proteins; D000071516:Alpha-Ketoglutarate-Dependent Dioxygenase FTO; C526492:FTO protein, human