title: The relationship between grey-matter and ASD and ADHD traits in typical adults.
abstract: We tested whether in 85 healthy adults (18-29 years) there is a relationship between grey-matter (GM) volume and autism and ADHD symptom severity. The structural MRI findings and autism and ADHD self-reports revealed that autism and ADHD symptom severity was correlated with GM volume in the left inferior frontal gyrus. Autism symptom-severity was correlated with the left posterior cingulate, ADHD with the right parietal lobe, right temporal frontal cortex, bilateral thalamus, and left hippocampus/amygdala complex. Symptom severity of both disorders form a continuum extending into the general population, but it seems to be an oversimplification to typify psychiatric disorders such as autism and ADHD solely as extremes of brain structure abnormalities.
authors.affiliation: Brain and Cognition, Department of Psychology, Universiteit van Amsterdam, Weesperplein 4, 1018 XA, Amsterdam, The Netherlands. h.m.geurts@uva.nl
authors.forename: Hilde M
authors.initials: HM
authors.lastname: Geurts
authors.forename: K Richard
authors.initials: KR
authors.lastname: Ridderinkhof
authors.forename: H Steven
authors.initials: HS
authors.lastname: Scholte
mesh_terms: D000293:Adolescent; D000328:Adult; D001289:Attention Deficit Disorder with Hyperactivity / Q000175:diagnosis* / Q000473:pathology* / Q000523:psychology; D001921:Brain / Q000473:pathology*; D002648:Child; D002659:Child Development Disorders, Pervasive / Q000175:diagnosis* / Q000473:pathology* / Q000523:psychology; D004292:Dominance, Cerebral / Q000502:physiology; D005260:Female; D006801:Humans; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D009929:Organ Size / Q000502:physiology; D012016:Reference Values; D055815:Young Adult