title: The role of radioactive iodine-125 seed localization in breast-conserving therapy following neoadjuvant chemotherapy.
abstract: BACKGROUND
  Neoadjuvant chemotherapy (NAC) is increasingly used in the framework of breast-conserving therapy (BCT). Localization of the initial tumor is essential to guide surgical resection after NAC. This study describes the results obtained with I-125 seed localization in BCT including NAC.
  
  
  METHODS
  Between January 2009 and December 2010, 85 patients treated with NAC and BCT after I-125 seed localization were included. Radiological and pathological response and resection margins were retrospectively evaluated.
  
  
  RESULTS
  BCT was carried out in 85 patients without secondary local excisions. Nineteen patients with unifocal tumors and seven patients with multifocal tumors showed a complete pathological response (P = 0.18). Tumor-free resection margins were obtained in 78 patients (50 patients with unifocal and 28 patients with multifocal tumors, P = 0.27). Focally involved margins were found in four patients (two patients with a unifocal and two patients with a multifocal tumor, P = 0.27). A subsequent mastectomy was carried out in three patients (two patients with multifocal tumors, P = 0.29).
  
  
  CONCLUSIONS
  BCT after NAC can be carried out successfully after initial localization with I-125 seeds in both unifocal and multifocal breast tumors with complete resection rates of >90%.
authors.affiliation: Department of Surgery, Amphia Hospital, Breda 4818 CK, the Netherlands. pgobardhan@amphia.nl
authors.forename: P D
authors.initials: PD
authors.lastname: Gobardhan
authors.forename: L L
authors.initials: LL
authors.lastname: de Wall
authors.forename: L
authors.initials: L
authors.lastname: van der Laan
authors.forename: A J
authors.initials: AJ
authors.lastname: ten Tije
authors.forename: D C H
authors.initials: DC
authors.lastname: van der Meer
authors.forename: E
authors.initials: E
authors.lastname: Tetteroo
authors.forename: P M P
authors.initials: PM
authors.lastname: Poortmans
authors.forename: E J T
authors.initials: EJ
authors.lastname: Luiten
mesh_terms: D000368:Aged; D001943:Breast Neoplasms / Q000000981:diagnostic imaging / Q000628:therapy*; D018270:Carcinoma, Ductal, Breast / Q000000981:diagnostic imaging / Q000628:therapy*; D017024:Chemotherapy, Adjuvant; D005260:Female; D006801:Humans; D015552:Injections, Intralesional; D007457:Iodine Radioisotopes / Q000008:administration & dosage; D015412:Mastectomy, Segmental / Q000379:methods*; D008875:Middle Aged; D020360:Neoadjuvant Therapy; D011877:Radionuclide Imaging; D019275:Radiopharmaceuticals / Q000008:administration & dosage; D016896:Treatment Outcome
chemical_list: D007457:Iodine Radioisotopes; D019275:Radiopharmaceuticals