title: Induction of skin sensitization is augmented in Nrf2-deficient mice.
abstract: Several in vitro DNA microarray studies have shown the importance of nuclear factor (erythroid-derived 2)-like 2 (Nrf2) in skin sensitization. Nevertheless, the exact in vivo role of the Nrf2-Keap1 pathway during the induction of skin sensitization remains unknown. To study the function of Nrf2, a local lymph node assay was performed in wild-type and Nrf2-deficient mice using 2,4-dinitrochlorobenzene. The Nrf2-deficient mice show a more pronounced response, indicating that Nrf2 is involved in dampening the induction of skin sensitization.
authors.affiliation: Department of Toxicogenomics, Maastricht University, The Netherlands. Jochem.van.der.Veen@rivm.nl
authors.forename: Jochem W
authors.initials: JW
authors.lastname: van der Veen
authors.forename: Eric R
authors.initials: ER
authors.lastname: Gremmer
authors.forename: Jolanda P
authors.initials: JP
authors.lastname: Vermeulen
authors.forename: Henk
authors.initials: H
authors.lastname: van Loveren
authors.forename: Janine
authors.initials: J
authors.lastname: Ezendam
mesh_terms: D000485:Allergens / Q000633:toxicity*; D000818:Animals; D002452:Cell Count; D017449:Dermatitis, Allergic Contact / Q000209:etiology* / Q000235:genetics / Q000473:pathology; D004137:Dinitrochlorobenzene / Q000633:toxicity; D007509:Irritants / Q000633:toxicity; D023441:Local Lymph Node Assay; D008198:Lymph Nodes / Q000187:drug effects* / Q000473:pathology; D008214:Lymphocytes / Q000187:drug effects / Q000378:metabolism / Q000473:pathology; D051379:Mice; D008810:Mice, Inbred C57BL; D018345:Mice, Knockout; D051267:NF-E2-Related Factor 2 / Q000172:deficiency* / Q000235:genetics; D012882:Skin Tests
chemical_list: D000485:Allergens; D004137:Dinitrochlorobenzene; D007509:Irritants; D051267:NF-E2-Related Factor 2; C495636:Nfe2l2 protein, mouse