title: Evaluation of a surrogate marker: validity and efficiency.
abstract: Statistical validation of a surrogate endpoint or surrogate marker has been studied for three decades. However, there is still no consensus on how to evaluate surrogate endpoints or surrogate markers. There is much confusion on which method should be used for the evaluation of a surrogate endpoint or surrogate marker. In this article, we clarify the statistical definitions of the surrogate endpoint and surrogate marker and introduce the concept of the validity and efficiency of a surrogate marker. We suggest the proportion of information gain can be used to evaluate the validity of a surrogate marker.
authors.affiliation: Department of Global Statistical Science, Eli Lilly and Company, Indianapolis, IN 46285, USA. quyo@lilly.com
authors.forename: Yongming
authors.initials: Y
authors.lastname: Qu
mesh_terms: D015415:Biomarkers / Q000032:analysis*; D003627:Data Interpretation, Statistical; D006801:Humans; D054928:Validation Studies as Topic
chemical_list: D015415:Biomarkers