title: Cidofovir treatment improves the pathology caused by the growth of human papillomavirus-positive cervical carcinoma xenografts in athymic nude mice.
abstract: Cidofovir has shown antiproliferative effects against human papillomavirus (HPV)-positive cells and successfully suppressed the growth of HPV-positive xenografts in athymic nude mice. The present study evaluated the effect of cidofovir on several disease parameters in this animal model. Intratumoral administration of cidofovir resulted in a beneficial effect on body weight gain, a reduction in splenomegaly, a partial restoration of tryptophan catabolism, and diminished the inflammatory state induced by the xenografts. Administration of cidofovir to tumor-free animals did not have a direct effect on these parameters. Beyond suppressing tumor growth, intratumoral treatment with cidofovir ameliorated the pathology associated with HPV-tumor growth.
authors.affiliation: Rega Institute, Laboratory of Virology and Chemotherapy, K.U.L, Leuven, Belgium.
authors.forename: Tim
authors.initials: T
authors.lastname: De Schutter
authors.forename: Graciela
authors.initials: G
authors.lastname: Andrei
authors.forename: Dimitri
authors.initials: D
authors.lastname: Topalis
authors.forename: Sophie
authors.initials: S
authors.lastname: Duraffour
authors.forename: Tania
authors.initials: T
authors.lastname: Mitera
authors.forename: Lieve
authors.initials: L
authors.lastname: Naesens
authors.forename: Joost
authors.initials: J
authors.lastname: van den Oord
authors.forename: Patrick
authors.initials: P
authors.lastname: Matthys
authors.forename: Robert
authors.initials: R
authors.lastname: Snoeck
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology / Q000627:therapeutic use*; D001921:Brain / Q000378:metabolism; D002100:Cachexia / Q000188:drug therapy / Q000209:etiology; D002277:Carcinoma / Q000150:complications / Q000188:drug therapy* / Q000473:pathology / Q000821:virology; D045744:Cell Line, Tumor; D000077404:Cidofovir; D016207:Cytokines / Q000097:blood; D003596:Cytosine / Q000031:analogs & derivatives* / Q000494:pharmacology / Q000627:therapeutic use; D005260:Female; D052162:Human papillomavirus 16; D006801:Humans; D007737:Kynurenine / Q000097:blood; D007958:Leukocyte Count; D008099:Liver / Q000187:drug effects / Q000473:pathology; D051379:Mice; D008819:Mice, Nude; D063065:Organophosphonates / Q000494:pharmacology / Q000627:therapeutic use*; D030361:Papillomavirus Infections / Q000150:complications / Q000188:drug therapy* / Q000473:pathology / Q000821:virology; D013154:Spleen / Q000187:drug effects / Q000473:pathology; D013163:Splenomegaly / Q000188:drug therapy / Q000209:etiology; D014364:Tryptophan / Q000097:blood; D047368:Tumor Burden / Q000187:drug effects; D002583:Uterine Cervical Neoplasms / Q000150:complications / Q000188:drug therapy* / Q000473:pathology / Q000821:virology; D023041:Xenograft Model Antitumor Assays
chemical_list: D000970:Antineoplastic Agents; D016207:Cytokines; D063065:Organophosphonates; D007737:Kynurenine; D014364:Tryptophan; D003596:Cytosine; D000077404:Cidofovir