title: α-lipoic acid reduces hypertension and increases baroreflex sensitivity in renovascular hypertensive rats.
abstract: Renovascular hypertension has robust effects on control of blood pressure, including an impairment in baroreflex mechanisms, which involves oxidative stress. Although &#945;-lipoic acid (LA) has been described as a potent antioxidant, its effect on renovascular hypertension and baroreflex sensitivity (BRS) has not been investigated. In the present study we analyzed the effects caused by chronic treatment with LA on blood pressure, heart rate and baroreflex sensitivity (sympathetic and parasympathetic components) in renovascular hypertensive rats. Male Wistar rats underwent 2-Kidney-1-Clip (2K1C) or sham surgery and were maintained untouched for four weeks to develop hypertension. Four weeks post-surgery, rats were treated with LA (60 mg/kg) or saline for 14 days orally. On the 15th day mean arterial pressure (MAP) and heart rate (HR) were recorded. In addition, baroreflex sensitivity test using phenylephrine (8 &#181;g/kg, i.v.) and sodium nitroprusside (25 &#181;g/kg, i.v.) was performed. Chronic treatment with LA decreased blood pressure in hypertensive animals; however, no significant changes in baseline HR were observed. Regarding baroreflex, LA treatment increased the sensitivity of both the sympathetic and parasympathetic components. All parameters studied were not affected by treatment with LA in normotensive animals. Our data suggest that chronic treatment with LA promotes antihypertensive effect and improves baroreflex sensitivity in rats with renovascular hypertension.
authors.affiliation: Biotechnology Center, Federal University of Paraiba, João Pessoa, PB 58.051-900, Brazil. thyagoqueiroz@gmail.com
authors.forename: Thyago M
authors.initials: TM
authors.lastname: Queiroz
authors.forename: Drielle D
authors.initials: DD
authors.lastname: Guimarães
authors.forename: Leônidas G
authors.initials: LG
authors.lastname: Mendes-Junior
authors.forename: Valdir A
authors.initials: VA
authors.lastname: Braga
mesh_terms: D058646:Adrenergic alpha-1 Receptor Agonists / Q000494:pharmacology; D000818:Animals; D000959:Antihypertensive Agents / Q000008:administration & dosage*; D000975:Antioxidants / Q000008:administration & dosage*; D017704:Baroreflex / Q000187:drug effects*; D001794:Blood Pressure / Q000187:drug effects; D006339:Heart Rate / Q000187:drug effects; D006978:Hypertension, Renovascular / Q000188:drug therapy*; D008297:Male; D020030:Nitric Oxide Donors / Q000494:pharmacology; D009599:Nitroprusside / Q000494:pharmacology; D010656:Phenylephrine / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D008063:Thioctic Acid / Q000008:administration & dosage*
chemical_list: D058646:Adrenergic alpha-1 Receptor Agonists; D000959:Antihypertensive Agents; D000975:Antioxidants; D020030:Nitric Oxide Donors; D009599:Nitroprusside; D010656:Phenylephrine; D008063:Thioctic Acid