title: Nimesulide may be more efficient than allopurinol in protecting pancreas from acute ischemia/reperfusion injury in an animal model.
abstract: OBJECTIVE
  To determine the influence of allopurinol and nimesulide in the protection of the pancreas from acute ischemia-reperfusion (I/R) injury.
  
  
  METHODS
  A total of 30 rabbits were divided into 3 groups, group A: acute I/R only; group B: allopurinol (30 mg/kg) was administered intravenously 10 minutes before ischemia; group C: nimesulide (50 mg/kg) was given intraperitoneally 20 minutes before ischemia. Neopterin and superoxide dismutase (SOD) levels were examined. Pancreatic biopsies were obtained for electron microscopy study.
  
  
  RESULTS
  The mean neopterin concentrations in group A are 3.56 ± 3.41, 7.74 ± 3.59, and 8.94 ± 2.86 ng/mL, respectively, in the stabilization, ischemia, and reperfusion phases; group B: 3.40 ± 3.03, 7.45 ± 8.89, and 10.64 ± 7.47 ng/mL; and group C: 3.41 ± 2.71, 5.67 ± 2.76, and 4.34 ± 2.87 ng/mL. The mean SOD concentrations in group A are 4.25 ± 1.79, 4.48 ± 1.60, and 5.57 ± 1.15 ng/mL; group B: 4.32 ± 0.81, 5.08 ± 1.10, and 4.45 ± 1.31 ng/mL; and group C: 4.10 ± 0.99, 5.23 ± 1.60, and 3.72 ± 1.30 ng/mL. Histopathology showed the least deterioration in group C.
  
  
  CONCLUSIONS
  Nimesulide is more efficient than allopurinol in protecting pancreas from acute I/R injury.
authors.affiliation: Department of Surgery, 424 Military Hospital, Thessaloniki, Greece.
authors.forename: Dimosthenis
authors.initials: D
authors.lastname: Apostolidis
authors.forename: Achilleas
authors.initials: A
authors.lastname: Ntinas
authors.forename: Dimitrios
authors.initials: D
authors.lastname: Kardassis
authors.forename: Nikolaos
authors.initials: N
authors.lastname: Koulouris
authors.forename: Olympia
authors.initials: O
authors.lastname: Thomareis
authors.forename: Georgia
authors.initials: G
authors.lastname: Karayannopoulou
authors.forename: Dionisios
authors.initials: D
authors.lastname: Vrochides
mesh_terms: D000493:Allopurinol / Q000008:administration & dosage / Q000494:pharmacology*; D000818:Animals; D015415:Biomarkers / Q000097:blood; D001706:Biopsy; D019610:Cytoprotection; D004195:Disease Models, Animal; D007262:Infusions, Intravenous; D007274:Injections, Intraperitoneal; D019798:Neopterin / Q000097:blood; D010179:Pancreas / Q000098:blood supply* / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology; D020011:Protective Agents / Q000008:administration & dosage / Q000494:pharmacology*; D011817:Rabbits; D015427:Reperfusion Injury / Q000097:blood / Q000473:pathology / Q000517:prevention & control*; D013449:Sulfonamides / Q000008:administration & dosage / Q000494:pharmacology*; D013482:Superoxide Dismutase / Q000097:blood; D013997:Time Factors
chemical_list: D015415:Biomarkers; D020011:Protective Agents; D013449:Sulfonamides; D000493:Allopurinol; D019798:Neopterin; D013482:Superoxide Dismutase; C012655:nimesulide