title: Effect of the embolization material in the dose calculation for stereotactic radiosurgery of arteriovenous malformations.
abstract: It is reported in the literature that the material used in an embolization of an arteriovenous malformation (AVM) can attenuate the radiation beams used in stereotactic radiosurgery (SRS) up to 10% to 15%. The purpose of this work is to assess the dosimetric impact of this attenuating material in the SRS treatment of embolized AVMs, using Monte Carlo simulations assuming clinical conditions. A commercial Monte Carlo dose calculation engine was used to recalculate the dose distribution of 20 AVMs previously planned with a pencil beam dose calculation algorithm. Dose distributions were compared using the following metrics: average, minimal and maximum dose of AVM, and 2D gamma index. The effect in the obliteration rate was investigated using radiobiological models. It was found that the dosimetric impact of the embolization material is less than 1.0 Gy in the prescription dose to the AVM for the 20 cases studied. The impact in the obliteration rate is less than 4.0%. There is reported evidence in the literature that embolized AVMs treated with SRS have low obliteration rates. This work shows that there are dosimetric implications that should be considered in the final treatment decisions for embolized AVMs.
authors.affiliation: Unidad de Radioneurocirugía, Instituto Nacional de Neurología y Neurocirugía, Mexico.
authors.forename: Olga Olinca
authors.initials: OO
authors.lastname: Galván de la Cruz
authors.forename: José Manuel
authors.initials: JM
authors.lastname: Lárraga-Gutiérrez
authors.forename: Sergio
authors.initials: S
authors.lastname: Moreno-Jiménez
authors.forename: Olivia Amanda
authors.initials: OA
authors.lastname: García-Garduño
authors.forename: Miguel Angel
authors.initials: MA
authors.lastname: Celis
mesh_terms: D000293:Adolescent; D000328:Adult; D003131:Combined Modality Therapy; D004621:Embolization, Therapeutic / Q000379:methods*; D005260:Female; D006490:Hemostatics / Q000627:therapeutic use*; D006801:Humans; D002538:Intracranial Arteriovenous Malformations / Q000628:therapy*; D008297:Male; D011874:Radiometry / Q000379:methods*; D016634:Radiosurgery / Q000379:methods*; D011879:Radiotherapy Dosage; D011880:Radiotherapy Planning, Computer-Assisted / Q000379:methods*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D055815:Young Adult
chemical_list: D006490:Hemostatics