title: Bioactive constituents of Salvia chrysophylla Stapf.
abstract: The dichloromethane extract of the aerial parts of Salvia chrysophylla Stapf (Lamiaceae), which is an endemic species to south-western Anatolia, was studied for non-volatile secondary metabolites for the first time in this study. Structures of the isolated compounds were elucidated as sclareol, β-sitosterol, salvigenin, oleanolic acid and ursolic acid. The lipid peroxidation inhibitory activity and the DPPH free radical scavenging activity of the pure isolates were investigated to establish their antioxidant potential. Their anticholinesterase activity was carried out by the Ellman assay against both enzymes, acetylcholinesterase (AChE) and butyrylcholinesterase, and diterpene sclareol exhibited fairly good activity against both the enzymes while the two triterpenoids oleanolic and ursolic acids exhibited selective activity against AChE.
authors.affiliation: Department of Organic Chemistry, Faculty of Science and Letters, Istanbul Technical University, Istanbul 34469, Turkey.
authors.forename: Burcu
authors.initials: B
authors.lastname: Çulhaoğlu
authors.forename: Gönül
authors.initials: G
authors.lastname: Yapar
authors.forename: Tuncay
authors.initials: T
authors.lastname: Dirmenci
authors.forename: Gülaçtı
authors.initials: G
authors.lastname: Topçu
mesh_terms: D000975:Antioxidants / Q000737:chemistry; D002800:Cholinesterase Inhibitors / Q000737:chemistry; D004224:Diterpenes / Q000737:chemistry; D047309:Flavones / Q000737:chemistry; D019686:Lamiaceae / Q000737:chemistry; D015227:Lipid Peroxidation / Q000187:drug effects; D008752:Methylene Chloride / Q000737:chemistry; D009828:Oleanolic Acid / Q000737:chemistry; D010936:Plant Extracts / Q000737:chemistry; D027544:Salvia / Q000737:chemistry*; D014315:Triterpenes / Q000737:chemistry; D000097245:Ursolic Acid
chemical_list: D000975:Antioxidants; D002800:Cholinesterase Inhibitors; D004224:Diterpenes; D047309:Flavones; D008752:Methylene Chloride; D009828:Oleanolic Acid; D010936:Plant Extracts; D014315:Triterpenes; D000097245:Ursolic Acid; C014049:salvigenin; C070760:sclareol