title: Meeting report: Spontaneous lesions and diseases in wild, captive-bred, and zoo-housed nonhuman primates and in nonhuman primate species used in drug safety studies.
abstract: The combination of loss of habitat, human population encroachment, and increased demand of select nonhuman primates for biomedical research has significantly affected populations. There remains a need for knowledge and expertise in understanding background findings as related to the age, source, strain, and disease status of nonhuman primates. In particular, for safety/biomedical studies, a broader understanding and documentation of lesions would help clarify background from drug-related findings. A workshop and a minisymposium on spontaneous lesions and diseases in nonhuman primates were sponsored by the concurrent Annual Meetings of the American College of Veterinary Pathologists and the American Society for Veterinary Clinical Pathology held December 3-4, 2011, in Nashville, Tennessee. The first session had presentations from Drs Lowenstine and Montali, pathologists with extensive experience in wild and zoo populations of nonhuman primates, which was followed by presentations of 20 unique case reports of rare or newly observed spontaneous lesions in nonhuman primates (see online files for access to digital whole-slide images corresponding to each case report at http://www.scanscope.com/ACVP%20Slide%20Seminars/2011/Primate%20Pathology/view.apml). The minisymposium was composed of 5 nonhuman-primate researchers (Drs Bradley, Cline, Sasseville, Miller, Hutto) who concentrated on background and spontaneous lesions in nonhuman primates used in drug safety studies. Cynomolgus and rhesus macaques were emphasized, with some material presented on common marmosets. Congenital, acquired, inflammatory, and neoplastic changes were highlighed with a focus on clinical, macroscopic, and histopathologic findings that could confound the interpretation of drug safety studies.
authors.affiliation: Novartis Institutes for Biomedical Research, 300 Technology Square, Cambridge, MA 02139, USA. vito.sasseville@novartis.com
authors.forename: V G
authors.initials: VG
authors.lastname: Sasseville
authors.forename: K G
authors.initials: KG
authors.lastname: Mansfield
authors.forename: J L
authors.initials: JL
authors.lastname: Mankowski
authors.forename: C
authors.initials: C
authors.lastname: Tremblay
authors.forename: K A
authors.initials: KA
authors.lastname: Terio
authors.forename: K
authors.initials: K
authors.lastname: Mätz-Rensing
authors.forename: E
authors.initials: E
authors.lastname: Gruber-Dujardin
authors.forename: M A
authors.initials: MA
authors.lastname: Delaney
authors.forename: L D
authors.initials: LD
authors.lastname: Schmidt
authors.forename: D
authors.initials: D
authors.lastname: Liu
authors.forename: J E
authors.initials: JE
authors.lastname: Markovits
authors.forename: M
authors.initials: M
authors.lastname: Owston
authors.forename: C
authors.initials: C
authors.lastname: Harbison
authors.forename: S
authors.initials: S
authors.lastname: Shanmukhappa
authors.forename: A D
authors.initials: AD
authors.lastname: Miller
authors.forename: S
authors.initials: S
authors.lastname: Kaliyaperumal
authors.forename: B T
authors.initials: BT
authors.lastname: Assaf
authors.forename: L
authors.initials: L
authors.lastname: Kattenhorn
authors.forename: S Cummings
authors.initials: SC
authors.lastname: Macri
authors.forename: H A
authors.initials: HA
authors.lastname: Simmons
authors.forename: A
authors.initials: A
authors.lastname: Baldessari
authors.forename: P
authors.initials: P
authors.lastname: Sharma
authors.forename: C
authors.initials: C
authors.lastname: Courtney
authors.forename: A
authors.initials: A
authors.lastname: Bradley
authors.forename: J M
authors.initials: JM
authors.lastname: Cline
authors.forename: J F
authors.initials: JF
authors.lastname: Reindel
authors.forename: D L
authors.initials: DL
authors.lastname: Hutto
authors.forename: R J
authors.initials: RJ
authors.lastname: Montali
authors.forename: L J
authors.initials: LJ
authors.lastname: Lowenstine
mesh_terms: D032761:Animal Experimentation; D000818:Animals; D000835:Animals, Wild; D000836:Animals, Zoo; D035843:Biomedical Research; D004353:Drug Evaluation, Preclinical; D005260:Female; D008252:Macaca fascicularis; D008253:Macaca mulatta; D008297:Male; D023421:Models, Animal; D018419:Primate Diseases / Q000473:pathology*; D011323:Primates