title: [Expression and significance of Runx3 in salivary adenoid cystic carcinoma].
abstract: OBJECTIVE
  To investigate the association between Runx3 expression and progression of salivary adenoid cystic carcinoma(SACC).
  
  
  METHODS
  The expression of Runx3 was examined in 4 pairs of primary SACC and adjacent salivary gland tissues from the same patient, using real-time PCR and Western blot. Furthermore, the Runx3 protein expression was analyzed in 65 clinicopathologically characterized SACC cases by immunohistochemistry. SPSS 17.0 software package was applied to complete data processing.Chi-square test was performed to determine the prognostic and diagnostic associations.
  
  
  RESULTS
  Runx3 expression was found to be remarkably downregulated in SACC tissues than that in the normal salivary gland tissues, at both mRNA and protein levels. Statistical analysis revealed a significant correlation of Runx3 expression with Lymph node metastasis.
  
  
  CONCLUSIONS
  The results suggest that Runx3 expression is associated with SACC progression, and might represent as a novel and valuable biomarker for clinical therapy of SACC patients.
authors.affiliation: Department of Oromaxillofacial-Head and Neck Surgery, China Medical University, Shenyang, Liaoning Province, China. daiweionline@gmail.com
authors.forename: Wei
authors.initials: W
authors.lastname: Dai
authors.forename: Xing-jun
authors.initials: XJ
authors.lastname: Qin
authors.forename: Xue-xin
authors.initials: XX
authors.lastname: Tan
authors.forename: Xu-dong
authors.initials: XD
authors.lastname: Wang
authors.forename: Chang-fu
authors.initials: CF
authors.lastname: Sun
mesh_terms: D015153:Blotting, Western; D003528:Carcinoma, Adenoid Cystic; D050677:Core Binding Factor Alpha 3 Subunit; D006801:Humans; D007150:Immunohistochemistry; D008207:Lymphatic Metastasis; D011379:Prognosis; D012333:RNA, Messenger; D012468:Salivary Gland Neoplasms; D012469:Salivary Glands
chemical_list: D050677:Core Binding Factor Alpha 3 Subunit; D012333:RNA, Messenger; C493729:Runx3 protein, human