title: [N-terminal proBNP and high sensivity cardiac troponin I concentrations in haemodialysis patients].
abstract: Assessment of serum biomarkers that are useful in stratification of early mortality and cardiovascular risk is very important in the treatment of patients on chronic haemodialysis. This study examined the relationship between high sensitivity cTnI and NT-proBNP according to glomerular filtration rates and vascular access (native AV-fistula or permanent catheter) in patients on haemodialysis. Concentrations of hs-cTnI and NT-pro BNP were increased in 35% and 100% of patients. According to their residual renal function, patients were divided in three groups: oligoanuric; diuresis 0.2-0.5 L/24H and diuresis 0.5 - 1.0 L/24h. The highest concentrations of NT-proBNP were in the first group and the third group showed the lowest NT-proBNP levels (p<0.05). The hs-cTnI concentrations showed no statistically significant differences between these groups. Patients with fistula accesses had lower levels of hs-cTnI and NT-proBNP than patients with permanent catheter, but these differences were not statistically significant. In patients with end-stage renal disease, interpretation of NT-proBNP levels should take into account residual diuresis. On the basis of our results, we suppose that high levels of hs-cTnI should be interpreted only as a consequence of myocardial necrosis. However, the correlation between NT-proBNP and hs-cTnI values in such patients should be further investigated.
authors.affiliation: Department for Medical Laboratory Diagnosis, Clinical Hospital Sveti Duh, Zagreb, Croatia.
authors.forename: Vlatko
authors.initials: V
authors.lastname: Rumenjak
authors.forename: Marina
authors.initials: M
authors.lastname: Brajković-Bralić
authors.forename: Vesna
authors.initials: V
authors.lastname: Varlaj-Knobloch
authors.forename: Dubravka
authors.initials: D
authors.lastname: Orsanić-Brcić
authors.forename: Ivana
authors.initials: I
authors.lastname: Brajković
authors.forename: Davor
authors.initials: D
authors.lastname: Marinković
authors.forename: Mia
authors.initials: M
authors.lastname: Knobloch
mesh_terms: D000368:Aged; D001166:Arteriovenous Shunt, Surgical; D002408:Catheters, Indwelling; D005260:Female; D006801:Humans; D007668:Kidney / Q000503:physiopathology; D007676:Kidney Failure, Chronic / Q000097:blood* / Q000503:physiopathology / Q000628:therapy; D008297:Male; D009206:Myocardium / Q000378:metabolism; D020097:Natriuretic Peptide, Brain / Q000097:blood*; D010446:Peptide Fragments / Q000097:blood*; D006435:Renal Dialysis; D019210:Troponin I / Q000097:blood*
chemical_list: D010446:Peptide Fragments; D019210:Troponin I; C109794:pro-brain natriuretic peptide (1-76); D020097:Natriuretic Peptide, Brain