title: Per3 VNTR polymorphism and chronic heart failure.
abstract: OBJECTIVE
  The aim of this study was to investigate the relationship between gene Period3 (Per3) variable number tandem repeat (VNTR) polymorphism and chronic heart failure (CHF).
  
  
  METHODS
  The study subjects (372 patients of Caucasian origin with CHF and 332 healthy controls) were genotyped for Per3 VNTR polymorphism using an allele-specific PCR.
  
  
  RESULTS
  No significant differences in genotype or Per3 VNTR allele frequencies were found between CHF cases and controls (Pg=0.30, Pa=0.52). No significant differences were uncovered either between CHF cases according to etiology (DCMP vs. IHD; Pg=0.87, Pa=0.91). In the multivariate regression modeling, no predictive function of VNTR Per3 polymorphism on ejection fraction or NYHA class, hyperlipidaemia or type II diabetes risk was found.
  
  
  CONCLUSIONS
  Per3 VNTR polymorphism is not a major risk factor for chronic heart failure or a factor modulating the severity of the CHF in this population.
authors.affiliation: Institute of Pathological Physiology, Faculty of Medicine, Masaryk University Brno, Czech Republic.
authors.forename: Jolana
authors.initials: J
authors.lastname: Lipkova
authors.forename: Julie Anna
authors.initials: JA
authors.lastname: Bienertova-Vasku
authors.forename: Lenka
authors.initials: L
authors.lastname: Spinarova
authors.forename: Petr
authors.initials: P
authors.lastname: Bienert
authors.forename: Marian
authors.initials: M
authors.lastname: Hlavna
authors.forename: Monika
authors.initials: M
authors.lastname: Pavkova Goldbergova
authors.forename: Jiri
authors.initials: J
authors.lastname: Parenica
authors.forename: Jindrich
authors.initials: J
authors.lastname: Spinar
authors.forename: Anna
authors.initials: A
authors.lastname: Vasku
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002908:Chronic Disease; D005260:Female; D005787:Gene Frequency; D006333:Heart Failure / Q000235:genetics*; D006801:Humans; D008297:Male; D008875:Middle Aged; D018598:Minisatellite Repeats; D056950:Period Circadian Proteins / Q000235:genetics*; D011110:Polymorphism, Genetic; D055815:Young Adult
chemical_list: C512644:PER3 protein, human; D056950:Period Circadian Proteins