title: Single dose oral pharmacokinetic profile of α-mangostin in mice.
abstract: The mangosteen fruit (Garcinia mangostana) is a rich source of dietary xanthones with the most prominent being α-mangostin. Dietary xanthones have been reported to have a variety of health promoting properties. Until now, in vivo studies on the pharmacokinetic profile of α-mangostin are limited. For this study we employed an LC/MS/MS assay to determine the pharmacokinetic properties of α-mangostin suspension in cottonseed oil in C57BL/6 Mice. Mice were administered 100 mg/kg of α-mangostin by oral gavage and the plasma levels were analyzed over a 24 hour period. We observed the degree of exposure (i.e. area under the curve) of α-mangostin to be 5,736 nmol/L/hr and the maximum plasma concentration was 1,382 nmol/L. Furthermore, we provide evidence that α-mangostin undergoes glucuronidation into monoglucuronide and diglucuronide metabolites. Our study demonstrated that α-mangostin when administered in cotton seed oil to mice at a dose equivalent to 615 mg in a 90kg human adult achieves an approximate maximum plasma concentration of 1,300 nmol/L and is detectable for up to 24 hours. Further research is needed to understand the relationship between the pharmacokinetic properties of α-mangostin following oral administration and reported health benefits.
authors.affiliation: Department of Pharmacy Practice, University of Illinois at Chicago, Chicago, IL 60612, USA.
authors.forename: Atulkumar
authors.initials: A
authors.lastname: Ramaiya
authors.forename: Gongbo
authors.initials: G
authors.lastname: Li
authors.forename: Sakina M
authors.initials: SM
authors.lastname: Petiwala
authors.forename: Jeremy J
authors.initials: JJ
authors.lastname: Johnson
mesh_terms: D000284:Administration, Oral; D000818:Animals; D029762:Garcinia mangostana; D006801:Humans; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D010936:Plant Extracts / Q000008:administration & dosage* / Q000097:blood / Q000493:pharmacokinetics*; D044004:Xanthones / Q000008:administration & dosage* / Q000097:blood / Q000493:pharmacokinetics*
chemical_list: D010936:Plant Extracts; D044004:Xanthones; C021053:mangostin