title: Adipokines in psoriatic arthritis patients: the correlations with osteoclast precursors and bone erosions.
abstract: Significant bone remodeling with disordered osteoclastogenesis has been implicated in the pathogenesis of psoriatic arthritis (PsA). And there is a high prevalence of the metabolic syndrome (MS) in PsA patients. Adipokines, especially leptin and adiponectin, have recently been reported to be involved in the development and regulation of some autoimmune diseases. In this study, we examined the alternation of circulating osteoclastogenesis related cytokines [tumor necrosis factor-α (TNF-α), osteoprotegerin (OPG) and receptor activator of nuclear factor-κB ligand (RANKL)] and adipokines (leptin, adiponectin, resistin, chemerin, omentin) in PsA patients, and analysed the correlations between these factors and osteoclast precursors numbers, radiographic damage scores, and disease activity index. 41 PsA patients, 20 psoriasis patients, and 24 healthy controls were recruited. Blood samples were obtained for detecting the levels of TNF-α, OPG, RANKL and the adipokines. The numbers of osteoclast precursors (OCs) in peripheral blood were assessed. Radiographs of affected joints in PsA patients were scored for erosion, joint-space narrowing, osteolysis, and new bone formation. Compared with healthy controls, patients with PsA had higher TNF-α, RANKL, OCs, leptin and omentin but lower adiponectin and chemerin. Increased serum levels of TNF-α, RANKL, leptin, and omentin were positively correlated with OCs numbers. In contrast, serum adiponectin levels were decreased in PsA patients and negatively correlated with OCs numbers. TNF-α, RANKL and leptin were positively correlated with Psoriatic Arthritis Joint Activity Index (PsAJAI). Only TNF-α was positively correlated with radiographic damage scores. Our data demonstrated that systemic expression of soluble mediators of osteoclastogenesis and adipokines were disordered in PsA. Certain adipokines were elevated in the circulation of patients with PsA and might contribute to pathogenesis of arthritis. Prospective studies will be of interest to determine the pluripotent effects of adipokines on osteoclastogenesis in chronic inflammatory rheumatic diseases. Future studies may lead to novel therapeutic strategies.
authors.affiliation: Department of Rheumatology, Huashan Hospital, Institute of Rheumatology, Immunology and Allergy, Fudan University, Shanghai, China.
authors.forename: Yu
authors.initials: Y
authors.lastname: Xue
authors.forename: Li
authors.initials: L
authors.lastname: Jiang
authors.forename: Qingqing
authors.initials: Q
authors.lastname: Cheng
authors.forename: Haiyan
authors.initials: H
authors.lastname: Chen
authors.forename: Yiyun
authors.initials: Y
authors.lastname: Yu
authors.forename: Yinda
authors.initials: Y
authors.lastname: Lin
authors.forename: Xue
authors.initials: X
authors.lastname: Yang
authors.forename: Ning
authors.initials: N
authors.lastname: Kong
authors.forename: Xiaoxia
authors.initials: X
authors.lastname: Zhu
authors.forename: Xue
authors.initials: X
authors.lastname: Xu
authors.forename: Weiguo
authors.initials: W
authors.lastname: Wan
authors.forename: Hejian
authors.initials: H
authors.lastname: Zou
mesh_terms: D054392:Adipokines / Q000097:blood*; D052242:Adiponectin / Q000097:blood; D000328:Adult; D000368:Aged; D000704:Analysis of Variance; D015535:Arthritis, Psoriatic / Q000097:blood* / Q000473:pathology; D016723:Bone Remodeling; D001862:Bone Resorption / Q000097:blood* / Q000473:pathology; D018925:Chemokines / Q000097:blood; D016207:Cytokines / Q000097:blood; D005260:Female; D058851:GPI-Linked Proteins / Q000097:blood; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins; D037102:Lectins / Q000097:blood; D020738:Leptin / Q000097:blood; D008297:Male; D008875:Middle Aged; D010010:Osteoclasts / Q000378:metabolism* / Q000473:pathology; D053244:Osteoprotegerin / Q000097:blood; D053245:RANK Ligand / Q000097:blood; D052243:Resistin / Q000097:blood; D014409:Tumor Necrosis Factor-alpha / Q000097:blood; D055815:Young Adult
chemical_list: D054392:Adipokines; D052242:Adiponectin; D018925:Chemokines; D016207:Cytokines; D058851:GPI-Linked Proteins; C432397:ITLN1 protein, human; D036341:Intercellular Signaling Peptides and Proteins; D037102:Lectins; D020738:Leptin; D053244:Osteoprotegerin; D053245:RANK Ligand; C478630:RARRES2 protein, human; D052243:Resistin; D014409:Tumor Necrosis Factor-alpha