title: The teratology testing of cosmetics.
abstract: In Europe, the developmental toxicity testing (including teratogenicity) of new cosmetic ingredients is performed according to the Cosmetics Directive 76/768/EEC: only alternatives leading to full replacement of animal experiments should be used. This chapter presents the three scientifically validated animal alternative methods for the assessment of embryotoxicity: the embryonic stem cell test (EST), the micromass (MM) assay, and the whole embryo culture (WEC) assay.
authors.affiliation: CiToxLAB, Evreux, France. Francois.Spezia@fr.citoxlab.com
authors.forename: François
authors.initials: F
authors.lastname: Spézia
authors.forename: Paul C
authors.initials: PC
authors.lastname: Barrow
mesh_terms: D000818:Animals; D002460:Cell Line; D003358:Cosmetics / Q000633:toxicity*; D046149:Embryo Culture Techniques; D053595:Embryonic Stem Cells / Q000187:drug effects; D033161:Government Regulation; D017408:Guidelines as Topic; D059630:Mesenchymal Stem Cells / Q000187:drug effects; D051379:Mice; D051381:Rats; D013723:Teratogens / Q000633:toxicity; D018600:Teratology / Q000331:legislation & jurisprudence / Q000379:methods*; D018675:Toxicity Tests / Q000379:methods* / Q000592:standards
chemical_list: D003358:Cosmetics; D013723:Teratogens