title: An update on spinal cord injury research.
abstract: Spinal cord injury (SCI) can have a range of debilitating effects and permanently alter the capabilities and quality of life of survivors. The first specialized centers of care for SCI were established in 1944 and since then an increasing amount of research has been carried out in this area. Despite this, the present treatment and care levels for SCI are not comparable to those in other areas of medicine. In the clinic, the aim of SCI treatment is primarily to limit secondary damage by reducing compression in trauma spots and stabilizing the spinal column. Currently, no effective strategy for functional recovery is offered. In this review, we focus on research progress on the molecular mechanisms underlying SCI, and assess the treatment outcomes of SCI in animal models, i.e., neurotrophins and stem cells are discussed as pre-clinical therapies in animal models. We also assess the resources available and national research projects carried out on SCI in China in recent years, as well as making recommendations for the future allocation of funds in this area.
authors.affiliation: Division of Neurological Disorders and Mental Health, Department of Health Sciences, National Natural Science Foundation of China, Beijing, 100085, China. caohq@nsfc.gov.cn
authors.forename: He-Qi
authors.initials: HQ
authors.lastname: Cao
authors.forename: Er-Dan
authors.initials: ED
authors.lastname: Dong
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D006801:Humans; D009414:Nerve Growth Factors / Q000627:therapeutic use*; D009416:Nerve Regeneration / Q000502:physiology*; D055495:Neurogenesis / Q000502:physiology*; D013119:Spinal Cord Injuries / Q000534:rehabilitation / Q000628:therapy*; D033581:Stem Cell Transplantation / Q000379:methods*
chemical_list: D009414:Nerve Growth Factors