title: Whole body static magnetic field exposure increases thermal nociceptive threshold in the snail, Helix pomatia.
abstract: We investigated the effect of homogeneous and inhomogeneous static magnetic field (SMF) exposure on the thermal nociceptive threshold of snail in the hot plate test (43 °C). Both homogeneous (hSMF) and inhomogeneous (iSMF) SMF increased the thermo-nociceptive threshold: 40.2%, 29.2%, or 41.7% after an exposure of 20, 30, or 40 min hSMF by p < 0.001, p < 0.0001, or p < 0.001, and 32.7% or 46.2% after an exposure of 20 or 40 min iSMF by p < 0.05 or p < 0.0001. These results suggest that SMF has an antinociceptive effect in snail. On the other hand, naloxone as an atypical opioid antagonist in an amount of 1 μg/g was found to significantly decrease the thermo-nociceptive threshold (41.9% by p < 0.002), which could be antagonized by hSMF exposure implying that hSMF exerts its antinociceptive effect partly via opioid receptors.
authors.affiliation: Department of Applied Mathematics and Probability Theory, University of Debrecen, Kassai út 26 H-4028 Debrecen, Hungary. laszlo.janos@inf.unideb.hu
authors.forename: J F
authors.initials: JF
authors.lastname: László
authors.forename: L
authors.initials: L
authors.lastname: Hernádi
mesh_terms: D000698:Analgesia / Q000379:methods*; D000818:Animals; D006372:Helix, Snails / Q000187:drug effects / Q000378:metabolism; D006358:Hot Temperature; D060526:Magnetic Fields; D009270:Naloxone / Q000494:pharmacology; D009292:Narcotic Antagonists / Q000494:pharmacology; D017288:Pain Threshold / Q000187:drug effects; D011957:Receptors, Opioid / Q000378:metabolism; D013697:Thermosensing / Q000187:drug effects; D013997:Time Factors
chemical_list: D009292:Narcotic Antagonists; D011957:Receptors, Opioid; D009270:Naloxone