title: Expression and the clinical significance of hPTTG1 in gastric cancer.
abstract: The aim of this study was to investigate the expression and clinical significance of hPTTG1 in gastric cancer. Immunohistochemistry was performed to determine the expression of hPTTG1 in gastric cancer tissues. Results showed that the positive expression of hPTTG1 in gastric cancer tissues was 60.00%, while in adjacent normal tissues it was 17.78%. The expression of hPTTG1 was correlated with differentiation levels, clinical classification and lymph node metastasis, but did not correlate with gender, age or pathological types. hPTTG1 was, therefore, overexpressed in gastric cancer tissues. The progression of gastric cancer was found to be correlated with the upregulation of the expression of hPTTG1. hPTTG1 detection may be helpful in evaluating the ability of the clinical classification and lymph node metastasis in gastric cancer to predict outcomes. These factors act as indicators of the biological behavior of gastric cancer and are fairly good markers for prognosis and therapy.
authors.affiliation: Department of Radiology, Zhejiang Provincial People's Hospital, Hangzhou 310014, PR China. zuyanluo@126.com
authors.forename: Zuyan
authors.initials: Z
authors.lastname: Luo
authors.forename: Bo
authors.initials: B
authors.lastname: Li
authors.forename: Junfa
authors.initials: J
authors.lastname: Chen
authors.forename: Yingyu
authors.initials: Y
authors.lastname: Ma
authors.forename: Houquan
authors.initials: H
authors.lastname: Tao
mesh_terms: D000328:Adult; D000368:Aged; D014408:Biomarkers, Tumor / Q000235:genetics / Q000378:metabolism; D018450:Disease Progression; D005260:Female; D015870:Gene Expression; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D011379:Prognosis; D064249:Securin / Q000235:genetics / Q000378:metabolism*; D013274:Stomach Neoplasms / Q000235:genetics / Q000378:metabolism* / Q000473:pathology*
chemical_list: D014408:Biomarkers, Tumor; D064249:Securin; C578002:pituitary tumor-transforming protein 1, human