title: Faecal microbiota transplantation for severe Clostridium difficile infection in the intensive care unit.
abstract: We describe a case of faecal microbiota transplantation (FMT) used for severe binary toxin-positive Clostridium difficile infection in an intensive care setting. The patient was admitted to the ICU of a tertiary hospital and failed traditional maximal pharmacological management. Adjunctive therapy with FMT given through gastroscopy resulted in resolution of the C. difficile-related symptoms. Although there is a growing experience with FMT for recurrent C. difficile infection, published evidence in severe disease is very limited. In a landscape of increasingly severe C. difficile infection, adjunctive FMT may be considered a useful early treatment option.
authors.affiliation: Department of Infectious Diseases, Austin Health, Heidelberg, Victoria, Australia. jason.trubiano@bigpond.com.au
authors.forename: Jason A
authors.initials: JA
authors.lastname: Trubiano
authors.forename: Bradley
authors.initials: B
authors.lastname: Gardiner
authors.forename: Jason C
authors.initials: JC
authors.lastname: Kwong
authors.forename: Peter
authors.initials: P
authors.lastname: Ward
authors.forename: Adam G
authors.initials: AG
authors.lastname: Testro
authors.forename: Patrick G P
authors.initials: PG
authors.lastname: Charles
mesh_terms: D000368:Aged; D016360:Clostridioides difficile; D003131:Combined Modality Therapy; D003422:Critical Care / Q000379:methods; D004761:Enterocolitis, Pseudomembranous / Q000628:therapy*; D017809:Fatal Outcome; D005243:Feces / Q000382:microbiology*; D005260:Female; D005773:Gastroscopy; D006801:Humans; D054892:Metagenome