title: Copper-catalyzed C-H azidation of anilines under mild conditions.
abstract: A novel and efficient copper-catalyzed azidation reaction of anilines via C-H activation has been developed. This method, in which the primary amine acts as a directing group by coordinating to the metal center, provides ortho azidation products regioselectively under mild conditions. This effective route for the synthesis of aryl azides is of great significance in view of the versatile reactivity of the azide products.
authors.affiliation: State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Xue Yuan Road 38, Beijing 100191, China.
authors.forename: Conghui
authors.initials: C
authors.lastname: Tang
authors.forename: Ning
authors.initials: N
authors.lastname: Jiao
mesh_terms: D000814:Aniline Compounds / Q000737:chemistry*; D001386:Azides / Q000737:chemistry*; D002244:Carbon / Q000737:chemistry*; D002384:Catalysis; D003300:Copper / Q000737:chemistry*; D006859:Hydrogen / Q000737:chemistry*
chemical_list: D000814:Aniline Compounds; D001386:Azides; D002244:Carbon; D003300:Copper; D006859:Hydrogen; C023650:aniline