title: Original β,γ-diamino acid as an inducer of a γ-turn mimic in short peptides.
abstract: Original αγα tripeptides containing one β,γ-diamino acid have been synthesized and their conformation determined by extensive NMR and molecular dynamic studies. These studies revealed the presence of a C(9) hydrogen bonded turn around the β,γ-diamino acid which was stabilized by bulky side chains of the preceding residue. This turn can be considered as a mimic of the well-known γ-turn.
authors.affiliation: Laboratoire de Chimie des Procédés et Substances Naturelles, ICMMO, UMR 8182, Univ Paris-Sud, CNRS, Bât 410, Orsay F-91405, France.
authors.forename: Sophie
authors.initials: S
authors.lastname: Thétiot-Laurent
authors.forename: Francelin
authors.initials: F
authors.lastname: Bouillère
authors.forename: Jean-Pierre
authors.initials: JP
authors.lastname: Baltaze
authors.forename: François
authors.initials: F
authors.lastname: Brisset
authors.forename: Debby
authors.initials: D
authors.lastname: Feytens
authors.forename: Cyrille
authors.initials: C
authors.lastname: Kouklovsky
authors.forename: Emeric
authors.initials: E
authors.lastname: Miclet
authors.forename: Valérie
authors.initials: V
authors.lastname: Alezra
mesh_terms: D000599:Amino Acids, Diamino / Q000737:chemistry*; D006860:Hydrogen Bonding; D008958:Models, Molecular; D019906:Nuclear Magnetic Resonance, Biomolecular; D009842:Oligopeptides / Q000138:chemical synthesis* / Q000737:chemistry*; D011487:Protein Conformation
chemical_list: D000599:Amino Acids, Diamino; D009842:Oligopeptides