title: Atrial electrical and structural remodeling: implications for racial differences in atrial fibrillation.
abstract: Racial Disparity in AF Electrophysiology. Racial differences in prevalence and incidence rates of atrial fibrillation (AF) are known to exist even after accounting for ascertainment bias, as well as differences in the prevalence of known risk factors. Thus, a different susceptibility to traditional risk factors in different ethnic groups that lead to AF clearly exists. Initiation and maintenance of AF are dependent on triggers, autonomic influence and atrial substrate, and progression to persistent AF occurs by electromechanical remodeling. Genetic differences among the racial group contribute to such differences. This article reviews the electrophysiologic mechanisms for AF, evidence for racial differences in susceptibility to AF, and suggests possible electromechanical reasons for the susceptibility.
authors.affiliation: Cardiology Division, Department of Medicine, Queen Mary Hospital, University of Hong Kong, Hong Kong SAR, China. cplau@hkucc.hku.hks
authors.forename: Chu-Pak
authors.initials: CP
authors.lastname: Lau
authors.forename: Hung-Fat
authors.initials: HF
authors.lastname: Tse
authors.forename: Chung-Wah
authors.initials: CW
authors.lastname: Siu
authors.forename: David
authors.initials: D
authors.lastname: Gbadebo
mesh_terms: D000200:Action Potentials; D001281:Atrial Fibrillation / Q000208:ethnology* / Q000235:genetics / Q000473:pathology / Q000503:physiopathology; D016275:Atrial Function; D001341:Autonomic Nervous System / Q000503:physiopathology; D020022:Genetic Predisposition to Disease; D054624:Health Status Disparities; D006325:Heart Atria / Q000473:pathology / Q000503:physiopathology; D006801:Humans; D015994:Incidence; D015995:Prevalence; D044469:Racial Groups / Q000235:genetics; D012307:Risk Factors