title: Full circle-old drugs prove more beneficial than newer agents for schizophrenia: a case report.
abstract: A 55-year-old female with a diagnosis of schizophrenia currently resides in an assisted living facility in a large metropolitan suburb. For approximately 25 years, the patient was relegated to a life of poor symptom control and social adjustment, largely due to nonadherence, relapse, and rehospitalization. The patient experienced a trial-and-error approach to drug therapy, which resulted in reliance on the older or first generation agents for symptom improvement. This case supports the assertion that the second-generation or atypical antipsychotics used to treat schizophrenia are no better than older drugs in terms of efficacy or tolerability.
authors.affiliation: Texas A&M Health Science Center, Rangel College of Pharmacy, Pharmaceutical Sciences, Kingsville, Texas 78363–8202, USA. veronin@pharmacy.tamhsc.edu
authors.forename: Michael A
authors.initials: MA
authors.lastname: Veronin
authors.forename: Kendra
authors.initials: K
authors.lastname: Colson
authors.forename: Michael E
authors.initials: ME
authors.lastname: Roffman
authors.forename: Marian W
authors.initials: MW
authors.lastname: Roman
mesh_terms: D014150:Antipsychotic Agents / Q000009:adverse effects / Q000627:therapeutic use*; D001590:Benztropine / Q000009:adverse effects / Q000627:therapeutic use; D001714:Bipolar Disorder / Q000175:diagnosis / Q000188:drug therapy / Q000451:nursing / Q000523:psychology; D001883:Borderline Personality Disorder / Q000175:diagnosis / Q000188:drug therapy / Q000451:nursing / Q000523:psychology; D057915:Drug Substitution; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D008137:Longitudinal Studies; D008875:Middle Aged; D011618:Psychotic Disorders / Q000175:diagnosis / Q000188:drug therapy / Q000451:nursing / Q000523:psychology; D012189:Retrospective Studies; D012559:Schizophrenia / Q000175:diagnosis / Q000188:drug therapy* / Q000451:nursing*; D012565:Schizophrenic Psychology; D012917:Social Adjustment; D013888:Thiothixene / Q000009:adverse effects / Q000627:therapeutic use; D016896:Treatment Outcome; D015430:Weight Gain / Q000187:drug effects
chemical_list: D014150:Antipsychotic Agents; D001590:Benztropine; D013888:Thiothixene