title: The Australian Twin Registry as a resource for genetic studies into ophthalmic traits.
abstract: The Australian Twin Registry (ATR) is a not-for-profit organization that coordinates research involving Australian twins and researchers. The ATR is one of the largest volunteer registries of its kind and contains over 33,000 twin pairs. The purpose of this review is to provide a broad overview of recent ophthalmic studies that have utilized the ATR for recruitment purposes. Such studies include the Australian Twin Eye Study (ATES) and the Genes in Myopia (GEM) study. The ATES and GEM studies have undertaken studies into the genetic influences on a number of ophthalmic traits through the use of heritability studies, linkage studies, genome-wide association studies, and candidate gene-based studies. An overview of these studies is provided in this review, as well as a description of the recruitment methodologies for both the ATES and GEM studies.
authors.affiliation: Royal Victorian Eye And Ear Hospital, University Of Melbourne, Australia. mschache@unimelb.edu.au
authors.forename: Maria
authors.initials: M
authors.lastname: Schache
authors.forename: Paul N
authors.initials: PN
authors.lastname: Baird
mesh_terms: D001315:Australia / Q000453:epidemiology; D004200:Diseases in Twins / Q000453:epidemiology / Q000235:genetics*; D015785:Eye Diseases, Hereditary / Q000235:genetics*; D055106:Genome-Wide Association Study; D006801:Humans; D009885:Ophthalmology; D012042:Registries; D014427:Twins / Q000235:genetics*