title: Genome-wide association analysis identifies new lung cancer susceptibility loci in never-smoking women in Asia.
abstract: To identify common genetic variants that contribute to lung cancer susceptibility, we conducted a multistage genome-wide association study of lung cancer in Asian women who never smoked. We scanned 5,510 never-smoking female lung cancer cases and 4,544 controls drawn from 14 studies from mainland China, South Korea, Japan, Singapore, Taiwan and Hong Kong. We genotyped the most promising variants (associated at P < 5 × 10(-6)) in an additional 1,099 cases and 2,913 controls. We identified three new susceptibility loci at 10q25.2 (rs7086803, P = 3.54 × 10(-18)), 6q22.2 (rs9387478, P = 4.14 × 10(-10)) and 6p21.32 (rs2395185, P = 9.51 × 10(-9)). We also confirmed associations reported for loci at 5p15.33 and 3q28 and a recently reported finding at 17q24.3. We observed no evidence of association for lung cancer at 15q25 in never-smoking women in Asia, providing strong evidence that this locus is not associated with lung cancer independent of smoking.
authors.affiliation: Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA.
authors.forename: Qing
authors.initials: Q
authors.lastname: Lan
authors.forename: Chao A
authors.initials: CA
authors.lastname: Hsiung
authors.forename: Keitaro
authors.initials: K
authors.lastname: Matsuo
authors.forename: Yun-Chul
authors.initials: YC
authors.lastname: Hong
authors.forename: Adeline
authors.initials: A
authors.lastname: Seow
authors.forename: Zhaoming
authors.initials: Z
authors.lastname: Wang
authors.forename: H Dean
authors.initials: HD
authors.lastname: Hosgood
authors.forename: Kexin
authors.initials: K
authors.lastname: Chen
authors.forename: Jiu-Cun
authors.initials: JC
authors.lastname: Wang
authors.forename: Nilanjan
authors.initials: N
authors.lastname: Chatterjee
authors.forename: Wei
authors.initials: W
authors.lastname: Hu
authors.forename: Maria Pik
authors.initials: MP
authors.lastname: Wong
authors.forename: Wei
authors.initials: W
authors.lastname: Zheng
authors.forename: Neil
authors.initials: N
authors.lastname: Caporaso
authors.forename: Jae Yong
authors.initials: JY
authors.lastname: Park
authors.forename: Chien-Jen
authors.initials: CJ
authors.lastname: Chen
authors.forename: Yeul Hong
authors.initials: YH
authors.lastname: Kim
authors.forename: Young Tae
authors.initials: YT
authors.lastname: Kim
authors.forename: Maria Teresa
authors.initials: MT
authors.lastname: Landi
authors.forename: Hongbing
authors.initials: H
authors.lastname: Shen
authors.forename: Charles
authors.initials: C
authors.lastname: Lawrence
authors.forename: Laurie
authors.initials: L
authors.lastname: Burdett
authors.forename: Meredith
authors.initials: M
authors.lastname: Yeager
authors.forename: Jeffrey
authors.initials: J
authors.lastname: Yuenger
authors.forename: Kevin B
authors.initials: KB
authors.lastname: Jacobs
authors.forename: I-Shou
authors.initials: IS
authors.lastname: Chang
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Mitsudomi
authors.forename: Hee Nam
authors.initials: HN
authors.lastname: Kim
authors.forename: Gee-Chen
authors.initials: GC
authors.lastname: Chang
authors.forename: Bryan A
authors.initials: BA
authors.lastname: Bassig
authors.forename: Margaret
authors.initials: M
authors.lastname: Tucker
authors.forename: Fusheng
authors.initials: F
authors.lastname: Wei
authors.forename: Zhihua
authors.initials: Z
authors.lastname: Yin
authors.forename: Chen
authors.initials: C
authors.lastname: Wu
authors.forename: She-Juan
authors.initials: SJ
authors.lastname: An
authors.forename: Biyun
authors.initials: B
authors.lastname: Qian
authors.forename: Victor Ho Fun
authors.initials: VH
authors.lastname: Lee
authors.forename: Daru
authors.initials: D
authors.lastname: Lu
authors.forename: Jianjun
authors.initials: J
authors.lastname: Liu
authors.forename: Hyo-Sung
authors.initials: HS
authors.lastname: Jeon
authors.forename: Chin-Fu
authors.initials: CF
authors.lastname: Hsiao
authors.forename: Jae Sook
authors.initials: JS
authors.lastname: Sung
authors.forename: Jin Hee
authors.initials: JH
authors.lastname: Kim
authors.forename: Yu-Tang
authors.initials: YT
authors.lastname: Gao
authors.forename: Ying-Huang
authors.initials: YH
authors.lastname: Tsai
authors.forename: Yoo Jin
authors.initials: YJ
authors.lastname: Jung
authors.forename: Huan
authors.initials: H
authors.lastname: Guo
authors.forename: Zhibin
authors.initials: Z
authors.lastname: Hu
authors.forename: Amy
authors.initials: A
authors.lastname: Hutchinson
authors.forename: Wen-Chang
authors.initials: WC
authors.lastname: Wang
authors.forename: Robert
authors.initials: R
authors.lastname: Klein
authors.forename: Charles C
authors.initials: CC
authors.lastname: Chung
authors.forename: In-Jae
authors.initials: IJ
authors.lastname: Oh
authors.forename: Kuan-Yu
authors.initials: KY
authors.lastname: Chen
authors.forename: Sonja I
authors.initials: SI
authors.lastname: Berndt
authors.forename: Xingzhou
authors.initials: X
authors.lastname: He
authors.forename: Wei
authors.initials: W
authors.lastname: Wu
authors.forename: Jiang
authors.initials: J
authors.lastname: Chang
authors.forename: Xu-Chao
authors.initials: XC
authors.lastname: Zhang
authors.forename: Ming-Shyan
authors.initials: MS
authors.lastname: Huang
authors.forename: Hong
authors.initials: H
authors.lastname: Zheng
authors.forename: Junwen
authors.initials: J
authors.lastname: Wang
authors.forename: Xueying
authors.initials: X
authors.lastname: Zhao
authors.forename: Yuqing
authors.initials: Y
authors.lastname: Li
authors.forename: Jin Eun
authors.initials: JE
authors.lastname: Choi
authors.forename: Wu-Chou
authors.initials: WC
authors.lastname: Su
authors.forename: Kyong Hwa
authors.initials: KH
authors.lastname: Park
authors.forename: Sook Whan
authors.initials: SW
authors.lastname: Sung
authors.forename: Xiao-Ou
authors.initials: XO
authors.lastname: Shu
authors.forename: Yuh-Min
authors.initials: YM
authors.lastname: Chen
authors.forename: Li
authors.initials: L
authors.lastname: Liu
authors.forename: Chang Hyun
authors.initials: CH
authors.lastname: Kang
authors.forename: Lingmin
authors.initials: L
authors.lastname: Hu
authors.forename: Chung-Hsing
authors.initials: CH
authors.lastname: Chen
authors.forename: William
authors.initials: W
authors.lastname: Pao
authors.forename: Young-Chul
authors.initials: YC
authors.lastname: Kim
authors.forename: Tsung-Ying
authors.initials: TY
authors.lastname: Yang
authors.forename: Jun
authors.initials: J
authors.lastname: Xu
authors.forename: Peng
authors.initials: P
authors.lastname: Guan
authors.forename: Wen
authors.initials: W
authors.lastname: Tan
authors.forename: Jian
authors.initials: J
authors.lastname: Su
authors.forename: Chih-Liang
authors.initials: CL
authors.lastname: Wang
authors.forename: Haixin
authors.initials: H
authors.lastname: Li
authors.forename: Alan Dart Loon
authors.initials: AD
authors.lastname: Sihoe
authors.forename: Zhenhong
authors.initials: Z
authors.lastname: Zhao
authors.forename: Ying
authors.initials: Y
authors.lastname: Chen
authors.forename: Yi Young
authors.initials: YY
authors.lastname: Choi
authors.forename: Jen-Yu
authors.initials: JY
authors.lastname: Hung
authors.forename: Jun Suk
authors.initials: JS
authors.lastname: Kim
authors.forename: Ho-Il
authors.initials: HI
authors.lastname: Yoon
authors.forename: Qiuyin
authors.initials: Q
authors.lastname: Cai
authors.forename: Chien-Chung
authors.initials: CC
authors.lastname: Lin
authors.forename: In Kyu
authors.initials: IK
authors.lastname: Park
authors.forename: Ping
authors.initials: P
authors.lastname: Xu
authors.forename: Jing
authors.initials: J
authors.lastname: Dong
authors.forename: Christopher
authors.initials: C
authors.lastname: Kim
authors.forename: Qincheng
authors.initials: Q
authors.lastname: He
authors.forename: Reury-Perng
authors.initials: RP
authors.lastname: Perng
authors.forename: Takashi
authors.initials: T
authors.lastname: Kohno
authors.forename: Sun-Seog
authors.initials: SS
authors.lastname: Kweon
authors.forename: Chih-Yi
authors.initials: CY
authors.lastname: Chen
authors.forename: Roel
authors.initials: R
authors.lastname: Vermeulen
authors.forename: Junjie
authors.initials: J
authors.lastname: Wu
authors.forename: Wei-Yen
authors.initials: WY
authors.lastname: Lim
authors.forename: Kun-Chieh
authors.initials: KC
authors.lastname: Chen
authors.forename: Wong-Ho
authors.initials: WH
authors.lastname: Chow
authors.forename: Bu-Tian
authors.initials: BT
authors.lastname: Ji
authors.forename: John K C
authors.initials: JK
authors.lastname: Chan
authors.forename: Minjie
authors.initials: M
authors.lastname: Chu
authors.forename: Yao-Jen
authors.initials: YJ
authors.lastname: Li
authors.forename: Jun
authors.initials: J
authors.lastname: Yokota
authors.forename: Jihua
authors.initials: J
authors.lastname: Li
authors.forename: Hongyan
authors.initials: H
authors.lastname: Chen
authors.forename: Yong-Bing
authors.initials: YB
authors.lastname: Xiang
authors.forename: Chong-Jen
authors.initials: CJ
authors.lastname: Yu
authors.forename: Hideo
authors.initials: H
authors.lastname: Kunitoh
authors.forename: Guoping
authors.initials: G
authors.lastname: Wu
authors.forename: Li
authors.initials: L
authors.lastname: Jin
authors.forename: Yen-Li
authors.initials: YL
authors.lastname: Lo
authors.forename: Kouya
authors.initials: K
authors.lastname: Shiraishi
authors.forename: Ying-Hsiang
authors.initials: YH
authors.lastname: Chen
authors.forename: Hsien-Chih
authors.initials: HC
authors.lastname: Lin
authors.forename: Tangchun
authors.initials: T
authors.lastname: Wu
authors.forename: Yi-Long
authors.initials: YL
authors.lastname: Wu
authors.forename: Pan-Chyr
authors.initials: PC
authors.lastname: Yang
authors.forename: Baosen
authors.initials: B
authors.lastname: Zhou
authors.forename: Min-Ho
authors.initials: MH
authors.lastname: Shin
authors.forename: Joseph F
authors.initials: JF
authors.lastname: Fraumeni
authors.forename: Dongxin
authors.initials: D
authors.lastname: Lin
authors.forename: Stephen J
authors.initials: SJ
authors.lastname: Chanock
authors.forename: Nathaniel
authors.initials: N
authors.lastname: Rothman
mesh_terms: D000230:Adenocarcinoma / Q000235:genetics*; D000077192:Adenocarcinoma of Lung; D000328:Adult; D000368:Aged; D044466:Asian People / Q000235:genetics; D002294:Carcinoma, Squamous Cell / Q000235:genetics*; D002879:Chromosomes, Human, Pair 10 / Q000235:genetics; D002884:Chromosomes, Human, Pair 15 / Q000235:genetics; D002886:Chromosomes, Human, Pair 17; D002895:Chromosomes, Human, Pair 5 / Q000235:genetics; D002896:Chromosomes, Human, Pair 6 / Q000235:genetics; D005260:Female; D056426:Genetic Loci; D020022:Genetic Predisposition to Disease; D055106:Genome-Wide Association Study; D006801:Humans; D008175:Lung Neoplasms / Q000235:genetics*; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D012907:Smoking