title: The impact of close surgical margins after radical hysterectomy for early-stage cervical cancer.
abstract: OBJECTIVE
  While it is known that positive surgical margins increase the risk of cervical cancer recurrence, little is known about the effect of close surgical margins (CSM). Therefore, we set out to determine the impact of margin status on recurrence and survival in patients with early-stage cervical cancer.
  
  
  METHODS
  A retrospective review was conducted of patients undergoing radical hysterectomy from 2000 to 2010 with Stage IA2-IIA cervical cancer. CSM were defined as ≤5mm; association with other clinicopathologic factors as well as recurrence and survival was evaluated.
  
  
  RESULTS
  Of the 119 patients, 75 (63%) with CSM had a recurrence rate of 24% compared to 9% without CSM. Though not independently associated with recurrence, CSM were significantly associated with positive lymph nodes (44% vs. 18%), positive parametria (33.3% vs. 2.3%), larger tumors (3.5 vs. 2.5cm), greater depth of stromal invasion (DOI) (84% vs. 33%), and lymphovascular space invasion (LVSI) (61.3% vs. 34.1%). We failed to find an association between adjuvant therapy and recurrence in those with CSM. Exploratory analysis revealed that a surgical margin of ≤2mm was significantly associated with an increased risk of overall recurrence (36% vs. 9%, p=0.009) as well as loco-regional recurrence (22% vs. 4%, p=0.0034).
  
  
  CONCLUSIONS
  Surgical margins of ≤5mm on radical hysterectomy specimens are often associated with other high or intermediate risk factors for recurrence. While not a proven independent risk factor, the distance to surgical margin may warrant further investigation as an intermediate risk factor along with tumor size, DOI and LVSI.
authors.affiliation: Department of Obstetrics and Gynecology, Division of Gynecologic Oncology, The Wexner Medical Center at the Ohio State University, Columbus OH, USA.
authors.forename: Georgia A
authors.initials: GA
authors.lastname: McCann
authors.affiliation: Department of Obstetrics and Gynecology, Division of Gynecologic Oncology, The Wexner Medical Center at the Ohio State University, Columbus OH, USA.
authors.forename: Susanne K
authors.initials: SK
authors.lastname: Taege
authors.affiliation: Department of Obstetrics and Gynecology, Division of Gynecologic Oncology, The Wexner Medical Center at the Ohio State University, Columbus OH, USA.
authors.forename: Christina E
authors.initials: CE
authors.lastname: Boutsicaris
authors.affiliation: Center for Biostatistics, The Wexner Medical Center at the Ohio State University, Columbus OH, USA.
authors.forename: Gary S
authors.initials: GS
authors.lastname: Phillips
authors.affiliation: Department of Obstetrics and Gynecology, Division of Gynecologic Oncology, The Wexner Medical Center at the Ohio State University, Columbus OH, USA.
authors.forename: Eric L
authors.initials: EL
authors.lastname: Eisenhauer
authors.affiliation: Department of Obstetrics and Gynecology, Division of Gynecologic Oncology, The Wexner Medical Center at the Ohio State University, Columbus OH, USA.
authors.forename: Jeffrey M
authors.initials: JM
authors.lastname: Fowler
authors.affiliation: Department of Obstetrics and Gynecology, Division of Gynecologic Oncology, The Wexner Medical Center at the Ohio State University, Columbus OH, USA.
authors.forename: David M
authors.initials: DM
authors.lastname: O'Malley
authors.affiliation: Department of Obstetrics and Gynecology, Division of Gynecologic Oncology, The Wexner Medical Center at the Ohio State University, Columbus OH, USA.
authors.forename: Larry J
authors.initials: LJ
authors.lastname: Copeland
authors.affiliation: Department of Obstetrics and Gynecology, Division of Gynecologic Oncology, The Wexner Medical Center at the Ohio State University, Columbus OH, USA.
authors.forename: David E
authors.initials: DE
authors.lastname: Cohn
authors.affiliation: Department of Obstetrics and Gynecology, Division of Gynecologic Oncology, The Wexner Medical Center at the Ohio State University, Columbus OH, USA. Electronic address: ritu.salani@osumc.edu.
authors.forename: Ritu
authors.initials: R
authors.lastname: Salani
mesh_terms: D000328:Adult; D005260:Female; D006801:Humans; D007044:Hysterectomy; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D009364:Neoplasm Recurrence, Local / Q000209:etiology / Q000473:pathology; D009367:Neoplasm Staging; D012189:Retrospective Studies; D002583:Uterine Cervical Neoplasms / Q000401:mortality / Q000473:pathology / Q000601:surgery*