title: Detection of IL-6 by magnetic nanoparticles grown with the assistance of mid-infrared lighting.
abstract: Nanomedical systems have attracted considerable attention primarily due to suitability in applications for specific cell selection through biomolecular targeting and rare cell detection enhancement in a diverse, multicellular population. In the present study, magnetic nanoparticles were prepared for use in high accuracy cell sensing. Magnetic nanoparticle growth was assisted by mid-infrared lighting. By this mechanism, a narrow window, estimated to be 2%, was achieved for the dimension distribution of grown nanoparticles. Combined with silicon nanowire (SiNW) transistors, a sensor with ultra high sensitivity for the detection of specific potential low abundance biomarkers has been achieved, which has been specifically used to detect interleukin-6 (IL-6) at extremely low concentrations. A novel biosensor with high sensitivity has been fabricated and utilized in the detection of IL-6 at 75 fM to 50 pM. The system consists of an SiNW transistor and magnetic nanoparticles with even dimension distribution. The novel sensor system is suitable for quantifying IL-6 at low concentrations in protein samples.
authors.affiliation: Department of General Surgery, Wuxi People's Hospital, Wuxi, Jiangsu 214023, PR China.
authors.forename: Xiufeng
authors.initials: X
authors.lastname: Jiang
authors.forename: Ye
authors.initials: Y
authors.lastname: Zhang
authors.forename: Xiaofei
authors.initials: X
authors.lastname: Miao
authors.forename: Zenghui
authors.initials: Z
authors.lastname: Li
authors.forename: Zengtao
authors.initials: Z
authors.lastname: Bao
authors.forename: Tong
authors.initials: T
authors.lastname: Wang
mesh_terms: D015374:Biosensing Techniques / Q000295:instrumentation / Q000379:methods*; D004797:Enzyme-Linked Immunosorbent Assay; D007259:Infrared Rays; D015850:Interleukin-6 / Q000378:metabolism*; D058185:Magnetite Nanoparticles / Q000737:chemistry / Q000648:ultrastructure; D053770:Nanowires; D012680:Sensitivity and Specificity; D012825:Silicon
chemical_list: D015850:Interleukin-6; D058185:Magnetite Nanoparticles; D012825:Silicon