title: Trends in the incidence and outcomes of disseminated intravascular coagulation in critically ill patients (2004-2010): a population-based study.
abstract: BACKGROUND
  The incidence and outcomes of disseminated intravascular coagulation (DIC) are incompletely defined. Therefore, we aimed to evaluate the trends in incidence and outcomes of critically ill patients with DIC.
  
  
  METHODS
  We conducted a population-based, retrospective cohort study evaluating consecutively admitted adult (≥ 18 years old) critically ill patients with DIC at the Mayo Clinic, Minnesota, from 2004 to 2010. DIC was diagnosed according to the International Society on Thrombosis and Hemostasis' overt DIC algorithm. Patients given a diagnosis of heparin-induced thrombocytopenia, thrombotic thrombocytopenic purpura, Child Pugh class C, or any known congenital or acquired coagulation disorders were excluded.
  
  
  RESULTS
  Of the 8,089 Olmsted County resident ICU admissions, a total of 154 patients met the DIC inclusion criteria. The overall incidence rate of DIC/100,000 person-years decreased from 26.2 (95% CI, 17.1-38.4) in 2004 to 18.6 (95% CI, 11.3-28.7) in 2010. The incidence rate of DIC increased with age in both men and women and was consistently higher in men, with the exception of the age group 18 to 39 years. The incidence rate/100,000 person-years of DIC in men decreased from 41.6 (95% CI, 25.4-64.2) in 2004 to 21.2 (95% CI, 10.6 37.9) in 2010 (P = .01), whereas in women, it did not change significantly (P = .79). The case fatality rate did not change significantly during the study period.
  
  
  CONCLUSIONS
  The incidence of DIC has decreased over the past decade, significantly in men, although the mortality rate remains the same. This is in agreement with trends in other critical care syndromes and could be attributable to improvements in health care delivery.
authors.affiliation: From Multidisciplinary Epidemiology and Translational Research in Intensive Care (METRIC), Mayo Clinic, Rochester, MN; Department of Medicine, Division of Pulmonary and Critical Care Medicine, Mayo Clinic, Rochester, MN.
authors.forename: Balwinder
authors.initials: B
authors.lastname: Singh
authors.affiliation: From Multidisciplinary Epidemiology and Translational Research in Intensive Care (METRIC), Mayo Clinic, Rochester, MN; Department of Health Sciences Research, Mayo Clinic, Rochester, MN.
authors.forename: Andrew C
authors.initials: AC
authors.lastname: Hanson
authors.affiliation: From Multidisciplinary Epidemiology and Translational Research in Intensive Care (METRIC), Mayo Clinic, Rochester, MN; Department of Medicine, Division of Pulmonary and Critical Care Medicine, Mayo Clinic, Rochester, MN.
authors.forename: Rabe
authors.initials: R
authors.lastname: Alhurani
authors.affiliation: Department of Medicine, Division of Pulmonary and Critical Care Medicine, Mayo Clinic, Rochester, MN; Guang An Men Hospital, China Academy of Chinese Medical Science, Beijing, China.
authors.forename: Shihan
authors.initials: S
authors.lastname: Wang
authors.affiliation: From Multidisciplinary Epidemiology and Translational Research in Intensive Care (METRIC), Mayo Clinic, Rochester, MN; Department of Anesthesiology, Division of Critical Care Medicine, Mayo Clinic, Rochester, MN.
authors.forename: Vitaly
authors.initials: V
authors.lastname: Herasevich
authors.affiliation: From Multidisciplinary Epidemiology and Translational Research in Intensive Care (METRIC), Mayo Clinic, Rochester, MN; Department of Medicine, Division of Pulmonary and Critical Care Medicine, Mayo Clinic, Rochester, MN.
authors.forename: Rodrigo
authors.initials: R
authors.lastname: Cartin-Ceba
authors.affiliation: From Multidisciplinary Epidemiology and Translational Research in Intensive Care (METRIC), Mayo Clinic, Rochester, MN; Department of Anesthesiology, Division of Critical Care Medicine, Mayo Clinic, Rochester, MN.
authors.forename: Daryl J
authors.initials: DJ
authors.lastname: Kor
authors.affiliation: Department of Medicine, Division of Hematology, Mayo Clinic, Rochester, MN.
authors.forename: Naseema
authors.initials: N
authors.lastname: Gangat
authors.affiliation: From Multidisciplinary Epidemiology and Translational Research in Intensive Care (METRIC), Mayo Clinic, Rochester, MN; Department of Medicine, Division of Pulmonary and Critical Care Medicine, Mayo Clinic, Rochester, MN; Guang An Men Hospital, China Academy of Chinese Medical Science, Beijing, China. Electronic address: li.guangxi@mayo.edu.
authors.forename: Guangxi
authors.initials: G
authors.lastname: Li
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000465:Algorithms; D015331:Cohort Studies; D015897:Comorbidity; D016638:Critical Illness / Q000453:epidemiology* / Q000401:mortality*; D004211:Disseminated Intravascular Coagulation / Q000453:epidemiology* / Q000401:mortality*; D005260:Female; D006801:Humans; D015994:Incidence; D007362:Intensive Care Units / Q000639:trends*; D008297:Male; D008875:Middle Aged; D008910:Minnesota / Q000453:epidemiology; D012189:Retrospective Studies; D015996:Survival Rate; D055815:Young Adult