title: Acrylic acid grafted guargum-nanosilica membranes for transdermal diclofenac delivery.
abstract: Green, hydrophobic device for controlled transdermal release of diclofenac sodium was designed from in situ nanosilica/acrylic acid grafted guargum membranes. Best grafting condition was assigned and nanocomposites were formed in situ using varying proportions of aqueous nanosilica sol. Nanocomposite/drug conjugates were formed by bringing down the medium pH from 9.0 to 7.0. The conjugates were characterized through infrared and solid state NMR spectroscopy, electron microscopy, hydro-swelling, surface contact angle, viscometry and biocompatibility. Most balanced property was exhibited by the membrane containing 1wt% nanosilica. It also had shown the highest encapsulation efficacy vis-à-vis slowest release as compared to others during experimentation in a Franz diffusion cell.
authors.affiliation: Department of Polymer Science and Technology, University of Calcutta, 92 A.P.C. Road, Calcutta 700009, India.
authors.forename: Arindam
authors.initials: A
authors.lastname: Giri
authors.forename: Tridib
authors.initials: T
authors.lastname: Bhunia
authors.forename: Samir Ranjan
authors.initials: SR
authors.lastname: Mishra
authors.forename: Luna
authors.initials: L
authors.lastname: Goswami
authors.forename: Asit Baran
authors.initials: AB
authors.lastname: Panda
authors.forename: Sagar
authors.initials: S
authors.lastname: Pal
authors.forename: Abhijit
authors.initials: A
authors.lastname: Bandyopadhyay
mesh_terms: D000179:Acrylates / Q000737:chemistry*; D000279:Administration, Cutaneous; D001407:Bacillus / Q000187:drug effects; D004008:Diclofenac / Q000008:administration & dosage* / Q000494:pharmacology; D016503:Drug Delivery Systems / Q000379:methods; D004926:Escherichia coli / Q000187:drug effects; D005685:Galactans / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D008351:Mannans / Q000737:chemistry*; D053761:Nanocomposites / Q000737:chemistry*; D053149:Plant Gums / Q000737:chemistry*; D012475:Salmonella / Q000187:drug effects; D012477:Salmonella enteritidis / Q000187:drug effects; D012485:Salmonella typhi / Q000187:drug effects; D012486:Salmonella typhimurium / Q000187:drug effects; D012822:Silicon Dioxide / Q000737:chemistry; D013055:Spectrophotometry, Infrared; D014783:Viscosity
chemical_list: D000179:Acrylates; D005685:Galactans; D008351:Mannans; D053149:Plant Gums; D004008:Diclofenac; D012822:Silicon Dioxide; C007894:guar gum; C036658:acrylic acid