title: Effect of hemodiafiltration on quality of life over time.
abstract: OBJECTIVE
  It is unclear if hemodiafiltration leads to a better quality of life compared with hemodialysis. It was, therefore, the aim of this study to assess the effect of hemodiafiltration on quality of life compared with hemodialysis in patients with ESRD.
  
  
  METHODS
  This study analyzed the data of 714 patients with a median follow-up of 2 years from the Convective Transport Study. The patients were enrolled between June of 2004 and December of 2009. The Convective Transport Study is a randomized controlled trial on the effect of online hemodiafiltration versus low-flux hemodialysis on all-cause mortality. Quality of life was assessed with the Kidney Disease Quality of Life-Short Form. This questionnaire provides data for a physical and mental composite score and describes kidney disease-specific quality of life in 12 domains. The domains have scales from 0 to 100.
  
  
  RESULTS
  There were no significant differences in changes in health-related quality of life over time between patients treated with hemodialysis (n=358) or hemodiafiltration (n=356). The quality of life domain patient satisfaction declined over time in both dialysis modalities (hemodialysis: -2.5/yr, -3.4 to -1.5, P<0.001; hemodiafiltration: -1.4/yr, -2.4 to -0.5, P=0.004).
  
  
  CONCLUSIONS
  Compared with hemodialysis, hemodiafiltration had no significant effect on quality of life over time.
authors.affiliation: Department of Nephrology and Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands.
authors.forename: Albert H A
authors.initials: AH
authors.lastname: Mazairac
authors.forename: G Ardine
authors.initials: GA
authors.lastname: de Wit
authors.forename: Muriel P C
authors.initials: MP
authors.lastname: Grooteman
authors.forename: E Lars
authors.initials: EL
authors.lastname: Penne
authors.forename: Neelke C
authors.initials: NC
authors.lastname: van der Weerd
authors.forename: Claire H
authors.initials: CH
authors.lastname: den Hoedt
authors.forename: Renée
authors.initials: R
authors.lastname: Lévesque
authors.forename: Marinus A
authors.initials: MA
authors.lastname: van den Dorpel
authors.forename: Menso J
authors.initials: MJ
authors.lastname: Nubé
authors.forename: Piet M
authors.initials: PM
authors.lastname: ter Wee
authors.forename: Michiel L
authors.initials: ML
authors.lastname: Bots
authors.forename: Peter J
authors.initials: PJ
authors.lastname: Blankestijn
mesh_terms: D000368:Aged; D005260:Female; D005500:Follow-Up Studies; D017583:Hemodiafiltration / Q000401:mortality / Q000523:psychology*; D006801:Humans; D007676:Kidney Failure, Chronic / Q000401:mortality / Q000523:psychology* / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D011788:Quality of Life; D006435:Renal Dialysis / Q000401:mortality / Q000523:psychology*; D011795:Surveys and Questionnaires; D016896:Treatment Outcome