title: ABCA1 mutation carriers with low high-density lipoprotein cholesterol are characterized by a larger atherosclerotic burden.
abstract: OBJECTIVE
  Low HDL-C is a potent risk factor for cardiovascular disease (CVD). Yet, mutations in ABCA1, a major determinant of circulating HDL-C levels, were previously not associated with CVD risk in cohort studies. To study the consequences of low plasma levels of high-density lipoprotein cholesterol (HDL-C) due to ATP-binding cassette transporter A1 (ABCA1) dysfunction for atherosclerotic vascular disease in the carotid arteries.
  
  
  RESULTS
  We performed 3.0 Tesla magnetic resonance imaging (MRI) measurements of the carotid arteries in 36 carriers of high impact functional ABCA1 mutations and 36 normolipidemic controls. Carriers presented with 42% lower HDL-C levels (P < 0.001), a larger mean wall area (18.6 ± 6.0 vs. 15.8 ± 4.3 mm(2); P = 0.02), a larger mean wall thickness (0.82 ± 0.21 vs. 0.70 ± 0.14 mm; P = 0.005), and a higher normalized wall index (0.37 ± 0.06 vs. 0.33 ± 0.04; P = 0.005) compared with controls, retaining significance after adjustment for smoking, alcohol consumption, systolic blood pressure, diabetes, body mass index, history of CVD, LDL-C, and statin use (P = 0.002).
  
  
  CONCLUSIONS
  Carriers of loss of function ABCA1 mutations display a larger atherosclerotic burden compared with age and sex-matched controls, implying a higher risk for CVD. Further studies are needed to elucidate the full function of ABCA1 in the protection against atherosclerosis. These data support the development of strategies to up-regulate ABCA1 in patients with established CVD.
authors.affiliation: Department of Vascular Medicine, Academic Medical Center, Amsterdam, The Netherlands.
authors.forename: Andrea E
authors.initials: AE
authors.lastname: Bochem
authors.forename: Diederik F
authors.initials: DF
authors.lastname: van Wijk
authors.forename: Adriaan G
authors.initials: AG
authors.lastname: Holleboom
authors.forename: Raphaël
authors.initials: R
authors.lastname: Duivenvoorden
authors.forename: Mahdi M
authors.initials: MM
authors.lastname: Motazacker
authors.forename: Geesje M
authors.initials: GM
authors.lastname: Dallinga-Thie
authors.forename: Eric
authors.initials: E
authors.lastname: de Groot
authors.forename: John J P
authors.initials: JJ
authors.lastname: Kastelein
authors.forename: Aart J
authors.initials: AJ
authors.lastname: Nederveen
authors.forename: G Kees
authors.initials: GK
authors.lastname: Hovingh
authors.forename: Erik S G
authors.initials: ES
authors.lastname: Stroes
mesh_terms: D064286:ATP Binding Cassette Transporter 1; D018528:ATP-Binding Cassette Transporters / Q000235:genetics*; D002340:Carotid Artery Diseases / Q000235:genetics* / Q000473:pathology; D017536:Carotid Artery, Common; D016022:Case-Control Studies; D008076:Cholesterol, HDL / Q000172:deficiency* / Q000235:genetics; D005260:Female; D006579:Heterozygote; D006720:Homozygote; D006801:Humans; D018810:Magnetic Resonance Angiography; D008297:Male; D008875:Middle Aged; D009154:Mutation / Q000235:genetics*; D058226:Plaque, Atherosclerotic / Q000235:genetics / Q000473:pathology
chemical_list: C577836:ABCA1 protein, human; D064286:ATP Binding Cassette Transporter 1; D018528:ATP-Binding Cassette Transporters; D008076:Cholesterol, HDL