title: Can the Pelargonium sidoides root extract EPs® 7630 prevent asthma attacks during viral infections of the upper respiratory tract in children?
abstract: BACKGROUND
  Asthma is a chronic disease characterized by airway inflammation. Viral infection initiates an immune inflammatory response that may produce asthma attacks. There is no effective preventing therapy for asthma attack during upper respiratory tract viral infections.
  
  
  OBJECTIVE
  To investigate the efficacy of 5 days of Pelargonium sidoides therapy for preventing asthma attack during upper respiratory tract viral infections.
  
  
  METHODS
  Sixty one asthmatic children with upper respiratory tract viral infection were enrolled in the study. The patients were randomized to receive Pelargonium sidoides daily for 5 days (n=30) or not (n=31). Before and after treatment, they all were examined and symptom scores were determined. Following five days treatment, children were evaluated whether or not they had an asthma attack.
  
  
  RESULTS
  Treatment with Pelargonium sidoides was not associated with a statistically significant differences in fever and muscle aches (p>0.05, Chi-square test). There were significant differences in cough frequency and nasal congestion between the groups (p<0.05, Chi-square test). There were statistically significant differences in having asthma attack between the groups (p<0.05, Chi-square). Pelargonium sidoides group had less frequency of asthma attack.
  
  
  CONCLUSIONS
  Our study shows that Pelargonium sidoides may prevent asthma attacks during upper respiratory tract viral infections.
authors.affiliation: Erciyes University School of Medicine, Pediatric Allergy and Asthma Unit, Kayseri, Turkey. tahanfulya@yahoo.com
authors.forename: Fulya
authors.initials: F
authors.lastname: Tahan
authors.forename: Melih
authors.initials: M
authors.lastname: Yaman
mesh_terms: D000293:Adolescent; D018927:Anti-Asthmatic Agents / Q000302:isolation & purification / Q000627:therapeutic use; D000998:Antiviral Agents / Q000302:isolation & purification / Q000627:therapeutic use; D001249:Asthma / Q000209:etiology* / Q000517:prevention & control*; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D031316:Pelargonium / Q000737:chemistry*; D008517:Phytotherapy; D010936:Plant Extracts / Q000627:therapeutic use*; D018517:Plant Roots / Q000737:chemistry; D012141:Respiratory Tract Infections / Q000150:complications* / Q000188:drug therapy* / Q000821:virology
chemical_list: D018927:Anti-Asthmatic Agents; D000998:Antiviral Agents; C476332:EPs 7630; D010936:Plant Extracts