title: The CD39-adenosinergic axis in the pathogenesis of immune and nonimmune diabetes.
abstract: Diabetes mellitus encompasses two distinct disease processes: autoimmune Type 1 (T1D) and nonimmune Type 2 (T2D) diabetes. Despite the disparate aetiologies, the disease phenotype of hyperglycemia and the associated complications are similar. In this paper, we discuss the role of the CD39-adenosinergic axis in the pathogenesis of both T1D and T2D, with particular emphasis on the role of CD39 and CD73.
authors.affiliation: Immunology Research Centre, St. Vincent's Hospital Melbourne, Fitzroy 3065, Australia.
authors.forename: Joanne S J
authors.initials: JS
authors.lastname: Chia
authors.forename: Jennifer L
authors.initials: JL
authors.lastname: McRae
authors.forename: Peter J
authors.initials: PJ
authors.lastname: Cowan
authors.forename: Karen M
authors.initials: KM
authors.lastname: Dwyer
mesh_terms: D000241:Adenosine / Q000378:metabolism*; D000818:Animals; D015703:Antigens, CD / Q000378:metabolism*; D001081:Apyrase / Q000378:metabolism*; D003922:Diabetes Mellitus, Type 1 / Q000209:etiology* / Q000378:metabolism* / Q000473:pathology; D003924:Diabetes Mellitus, Type 2 / Q000209:etiology* / Q000378:metabolism* / Q000473:pathology; D006801:Humans; D010179:Pancreas / Q000201:enzymology / Q000473:pathology; D015398:Signal Transduction
chemical_list: D015703:Antigens, CD; D001081:Apyrase; C067869:CD39 antigen; D000241:Adenosine