title: Effect of renal denervation procedure on left ventricular hypertrophy of hypertensive rats and its mechanisms.
abstract: OBJECTIVE
  To investigate the effect of renal denervation (RDN) on the blood pressure, left ventricular hypertrophy and myocardial expression of TLR4/NF-κB in spontaneously hypertensive rats (SHR).
  
  
  METHODS
  A total of 36 SHR were randomly assigned into control group (D0), RDN group (D) and sham group (S). 12 WKY rats of same age served as controls (WKY group). Rats in the D0 and WKY groups were sacrificed, but rats in the D and S group were sacrificed at one week and six weeks after surgery. The heart was collected and the left ventricle weighted followed by calculation of left ventricular mass index (LVMI).
  
  
  RESULTS
  In the D0 group, the blood pressure, LVMI and protein expression of TLR4, NF-κB, TNF-α and IL-6 in the myocardium were markedly higher than that in the WKY group (p<0.05). In the D1 and D2 group, the LVMI, NE and protein expression of TLR4, NF-κB, TNF-α and IL-6 in the myocardium were significantly reduced (p<0.05).
  
  
  CONCLUSIONS
  Renal denervation can significantly delay the progression of left ventricular hypertrophy in spontaneously hypertensive rats, which may be attributed to the not only the suppression of sympathetic activity and attenuation of pressure load but the improvement of myocardial immuno-inflammation.
authors.affiliation: Department of Cardiology, Third Xiangya Hospital, Central South University, Changsha, China.
authors.forename: Weihong
authors.initials: W
authors.lastname: Jiang
authors.forename: Lihua
authors.initials: L
authors.lastname: Tan
authors.forename: Yunzhong
authors.initials: Y
authors.lastname: Guo
authors.forename: Xiaogang
authors.initials: X
authors.lastname: Li
authors.forename: Xiaohong
authors.initials: X
authors.lastname: Tang
authors.forename: Kan
authors.initials: K
authors.lastname: Yang
mesh_terms: D000818:Animals; D001794:Blood Pressure / Q000502:physiology*; D015153:Blotting, Western; D003714:Denervation / Q000379:methods*; D006973:Hypertension / Q000601:surgery*; D017379:Hypertrophy, Left Ventricular / Q000601:surgery*; D007150:Immunohistochemistry; D015850:Interleukin-6 / Q000032:analysis; D007668:Kidney / Q000294:innervation*; D016014:Linear Models; D009206:Myocardium / Q000737:chemistry; D016328:NF-kappa B / Q000032:analysis; D011897:Random Allocation; D051381:Rats; D011918:Rats, Inbred SHR; D011921:Rats, Inbred WKY; D013564:Sympathetic Nervous System / Q000503:physiopathology; D051197:Toll-Like Receptor 4 / Q000032:analysis; D014409:Tumor Necrosis Factor-alpha / Q000032:analysis
chemical_list: D015850:Interleukin-6; D016328:NF-kappa B; D051197:Toll-Like Receptor 4; D014409:Tumor Necrosis Factor-alpha