title: HLA-G5 in the blood of leukemia patients and healthy individuals.
abstract: In this work we focused on analysis of HLA-G5 molecules in the blood of patients with B-CLL leukemia and healthy individuals. Using sandwich ELISA, we found total soluble HLA-G, represented by sHLA-G1 and HLA-G5 in most of B-CLL patients while HLA-G5 alone was present only in few cases in both groups. These results lead us to assume that the majority of soluble HLA-G in blood is generated by proteolytic cleavage and shedding of membrane-bound HLA-G1. There is no correlation between the presence of HLA-G5 in blood of B-CLL patients and the stage of disease, age, and gender.
authors.affiliation: Cancer Research Institute, Slovak Academy of Sciences, Bratislava, Slovak Republic.
authors.forename: Katarína
authors.initials: K
authors.lastname: Poláková
authors.forename: Tatiana
authors.initials: T
authors.lastname: Železníková
authors.forename: Gustáv
authors.initials: G
authors.lastname: Russ
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D016022:Case-Control Studies; D002460:Cell Line; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D059951:HLA-G Antigens / Q000097:blood* / Q000276:immunology; D006801:Humans; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000097:blood* / Q000276:immunology; D008297:Male; D008875:Middle Aged
chemical_list: D059951:HLA-G Antigens