title: Polyphenol derivatives - potential regulators of neutrophil activity.
abstract: The study provides new information on the effect of natural polyphenols (derivatives of stilbene - resveratrol, pterostilbene, pinosylvin and piceatannol and derivatives of ferulic acid - curcumin, N-feruloylserotonin) on the activity of human neutrophils in influencing oxidative burst. All the polyphenols tested were found to reduce markedly the production of reactive oxygen species released by human neutrophils on extra-and intracellular levels as well as in cell free system. Moreover, pinosylvin, curcumin, N-feruloylserotonin and resveratrol decreased protein kinase C activity involved in neutrophil signalling and reactive oxygen species production. Our results suggest that due to their anti-neutrophil activity, the polyphenols tested might be attractive candidates in therapeutic development.
authors.affiliation: Institute of Experimental Pharmacology & Toxicology, Slovak Academy of Sciences, SK-84104 Bratislava, Slovakia.
authors.forename: Katarína
authors.initials: K
authors.lastname: Drábiková
authors.forename: Tomáš
authors.initials: T
authors.lastname: Perečko
authors.forename: Radomír
authors.initials: R
authors.lastname: Nosáľ
authors.forename: Juraj
authors.initials: J
authors.lastname: Harmatha
authors.forename: Jan
authors.initials: J
authors.lastname: Smidrkal
authors.forename: Viera
authors.initials: V
authors.lastname: Jančinová
keywords: activity of neutrophils; natural polyphenols; reactive oxygen species