title: Odd RNA polymerases or the A(B)C of eukaryotic transcription.
abstract: Pioneering studies on eukaryotic transcription were undertaken with the bacterial system in mind. Will the bacterial paradigm apply to eukaryotes? Are there promoter sites scattered in the eukaryotic genome, and sigma-like proteins? Why three forms of RNA polymerase in eukaryotic cells? Why are they structurally so complex, in particular RNA polymerases I and III, compared to the bacterial enzyme? These questions and others that were raised along the way are evoked in this short historical survey of odd RNA polymerases studies, with some emphasis on the contribution of these studies to our global understanding of eukaryotic transcription systems. This article is part of a Special Issue entitled: Transcription by Odd Pols.
authors.affiliation: CEA-Saclay, iBiTecS, F-91191 Gif-sur-Yvette cedex, France. sentenac@dsvidf.cea.fr
authors.forename: André
authors.initials: A
authors.lastname: Sentenac
authors.forename: Michel
authors.initials: M
authors.lastname: Riva
mesh_terms: D000818:Animals; D056890:Eukaryota / Q000201:enzymology; D006801:Humans; D012318:RNA Polymerase I / Q000378:metabolism*; D012320:RNA Polymerase III / Q000378:metabolism*; D014158:Transcription, Genetic
chemical_list: D012318:RNA Polymerase I; D012320:RNA Polymerase III