title: From randomized trials to the clinic: is it time to implement individual lung-cancer screening in clinical practice? A multidisciplinary statement from French experts on behalf of the French intergroup (IFCT) and the groupe d'Oncologie de langue francaise (GOLF).
abstract: BACKGROUND
  Despite advances in cancer therapy, mortality is still high except in early-stage tumors, and screening remains a challenge. The randomized National Lung Screening Trial (NLST), comparing annual low-dose computed tomography (LDCT) and chest X-rays, revealed a 20% decrease in lung-cancer-specific mortality. These results raised numerous questions. The French intergroup for thoracic oncology and the French-speaking oncology group convened an expert group to provide a coherent outlook on screening modalities in France.
  
  
  METHODS
  A literature review was carried out and transmitted to the expert group, which was divided into three workshops to tackle specific questions, with responses presented in a plenary session. A writing committee drafted this article.
  
  
  RESULTS
  The multidisciplinary group favored individual screening in France, when carried out as outlined in this article and after informing subjects of the benefits and risks. The target population involves subjects aged 55-74 years, who are smokers or have a 30 pack-year smoking history. Subjects should be informed about the benefits of quitting. Screening should involve LDCT scanning with specific modalities. Criteria for CT positivity and management algorithms for positive examinations are given.
  
  
  CONCLUSIONS
  Individual screening requires rigorous assessment and precise research in order to potentially develop a lung-cancer screening policy.
authors.affiliation: Respiratory Diseases Department,  'Hospices Civils de Lyon' Lyon University Hospital, Pierre-Bénite.
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mesh_terms: D000368:Aged; D003245:Consensus Statements as Topic; D055088:Early Detection of Cancer; D005602:France; D006801:Humans; D008175:Lung Neoplasms / Q000000981:diagnostic imaging* / Q000628:therapy; D008875:Middle Aged; D013902:Radiography, Thoracic; D016032:Randomized Controlled Trials as Topic; D012907:Smoking; D014057:Tomography, X-Ray Computed