title: Autoimmune rheumatic disease associated symptoms in fibromyalgia patients and their influence on anxiety, depression and somatisation: a comparative study.
abstract: OBJECTIVE
  In this study we evaluated the frequency of autoimmune rheumatic disease associated major symptoms in fibromyalgia (FM) patients, and the association between their presence and anxiety, depression and somatisation.
  
  
  METHODS
  Two hundred and thirty-two FM, 78 systemic lupus erythematosus (SLE) patients and 70 healthy controls were included. All subjects were questioned face-to-face for the presence of autoimmune rheumatic disease-associated symptoms and antinuclear antibody (ANA) was determined. All FM patients were questioned for the severity of pain and symptoms of FM by using a visual analogue scale. In addition, all subjects were interrogated for anxiety, depression, somatic symptoms and neuropathic pain by using different validated questionnaires.
  
  
  RESULTS
  FM patients had significantly higher frequency of photosensitivity (27.6% vs. 11.4%) and Raynaud phenomenon (22% vs. 10%) when compared to controls (p-values, 0.005 and 0.026). FM patients had significantly lower frequencies of photosensitivity, oral ulcers, xerostomia, and xerophthalmia than SLE patients (all p-values <0.001). ANA positivity was 11.8% in FM patients and 7.1% in healthy controls. ANA-positive and negative FM patients had similar frequencies of autoimmune rheumatic disease symptoms. FM patients with photosensitivity had higher anxiety (p=0.002), somatic symptoms (p=0.015) and neuropathic pain (p=0.03) scores than others. FM patients with Raynaud had higher anxiety (p=0.004), depression (p=0.001), somatic symptom (p<0.001) and neuropathic pain scores than others.
  
  
  CONCLUSIONS
  The presence of which findings in FM seems to be associated with anxiety, depression, and somatization rather than ANA positivity and disease severity.
authors.affiliation: Division of Rheumatology, Trakya University Medical Faculty, Edirne, Turkey. drsalimdonmez@hotmail.com
authors.forename: Salim
authors.initials: S
authors.lastname: Dönmez
authors.forename: Ömer Nuri
authors.initials: ÖN
authors.lastname: Pamuk
authors.forename: Elif Gülsüm
authors.initials: EG
authors.lastname: Ümit
authors.forename: Mehmet Şerif
authors.initials: MŞ
authors.lastname: Top
mesh_terms: D000328:Adult; D000704:Analysis of Variance; D000974:Antibodies, Antinuclear / Q000097:blood; D001007:Anxiety / Q000175:diagnosis / Q000453:epidemiology* / Q000523:psychology; D015415:Biomarkers / Q000097:blood; D016009:Chi-Square Distribution; D003863:Depression / Q000175:diagnosis / Q000453:epidemiology* / Q000523:psychology; D005356:Fibromyalgia / Q000175:diagnosis / Q000453:epidemiology* / Q000523:psychology; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000175:diagnosis / Q000453:epidemiology* / Q000523:psychology; D008875:Middle Aged; D019226:Oral Ulcer / Q000453:epidemiology / Q000523:psychology; D010146:Pain / Q000453:epidemiology / Q000523:psychology; D010147:Pain Measurement; D010787:Photosensitivity Disorders / Q000453:epidemiology / Q000523:psychology; D011237:Predictive Value of Tests; D011569:Psychiatric Status Rating Scales; D011928:Raynaud Disease / Q000453:epidemiology / Q000523:psychology; D012216:Rheumatic Diseases / Q000175:diagnosis / Q000453:epidemiology* / Q000523:psychology; D012720:Severity of Illness Index; D013001:Somatoform Disorders / Q000175:diagnosis / Q000453:epidemiology* / Q000523:psychology; D011795:Surveys and Questionnaires; D014421:Turkey / Q000453:epidemiology; D014985:Xerophthalmia / Q000453:epidemiology / Q000523:psychology; D014987:Xerostomia / Q000453:epidemiology / Q000523:psychology
chemical_list: D000974:Antibodies, Antinuclear; D015415:Biomarkers