title: Fabrication of mesoporous silica shells on solid silica spheres using anionic surfactants and their potential application in controlling drug release.
abstract: In this work, mesoporous shells were constructed on solid silica cores by employing anionic surfactante. A co-structure directing agent (CSDA) has assisted the electrostatic interaction between negatively charged silica particles and the negatively charged surfactant molecules. Synthetic parameters such as reaction time and temperature had a significant impact on the formation of mesoporous silica shelld and their textural properties such as surface area and pore volume. Core-mesoporous shell silica spheres were characterized by small angle X-ray scattering, transmission electron microscopy, and N(2) adsorption&#8211;desorption analysis. The synthesized particles have a uniformly mesoporous shell of 34&#8211;65 nm and possess a surface area of ca. 7&#8211;324 m2/g, and pore volume of ca. 0.008&#8211;0.261 cc/g. The core-mesoporous shell silica spheres were loaded with ketoprofen drug molecules. The in vitro drug release study suggested that core-mesoporous shell silica spheres are a suitable nanocarrier for drug molecules offering the possibility of having control over their release rate.
authors.affiliation: King Abdullah Institute for Nanotechnology, King Saud University, Riyadh 11451, Saudi Arabia. aamohammad@ksu.edu.sa
authors.forename: Ahmed Mohamed
authors.initials: AM
authors.lastname: El-Toni
authors.forename: Aslam
authors.initials: A
authors.lastname: Khan
authors.forename: Mohamed Abbas
authors.initials: MA
authors.lastname: Ibrahim
authors.forename: Mansour
authors.initials: M
authors.lastname: Al-Hoshan
authors.forename: Joselito Puzon
authors.initials: JP
authors.lastname: Labis
mesh_terms: D000327:Adsorption; D003692:Delayed-Action Preparations / Q000138:chemical synthesis* / Q000737:chemistry; D004337:Drug Carriers / Q000138:chemical synthesis* / Q000737:chemistry; D007660:Ketoprofen / Q000737:chemistry; D054118:Nanospheres / Q000737:chemistry* / Q000648:ultrastructure; D010316:Particle Size; D016062:Porosity; D011205:Povidone / Q000737:chemistry; D011437:Propylamines / Q000737:chemistry; D012521:Sarcosine / Q000031:analogs & derivatives / Q000737:chemistry; D053838:Scattering, Small Angle; D012821:Silanes / Q000737:chemistry; D012822:Silicon Dioxide / Q000737:chemistry*; D012996:Solutions; D013501:Surface-Active Agents / Q000737:chemistry*; D014961:X-Ray Diffraction
chemical_list: D003692:Delayed-Action Preparations; D004337:Drug Carriers; D011437:Propylamines; D012821:Silanes; D012996:Solutions; D013501:Surface-Active Agents; C088294:3-aminopropyltrimethoxysilane; C040733:tetraethoxysilane; C025231:sarkosyl; D012822:Silicon Dioxide; D007660:Ketoprofen; D011205:Povidone; D012521:Sarcosine