title: Caught in translation: innate restriction of HIV mRNA translation by a schlafen family protein.
abstract: Human immunodeficiency virus type 1 (HIV-1) is the cause of AIDS. In recent years it has emerged that cellular interferon-stimulated genes (ISG), play important roles in cell-intrinsic restriction of HIV replication. A publication now describes a novel strategy employed by HIV-infected cells to restrict viral replication, which involves inhibition of viral mRNA translation by the ISG Schlafen 11.
authors.affiliation: Department of Biomedicine, University of Aarhus, Aarhus, Denmark.
authors.forename: Martin R
authors.initials: MR
authors.lastname: Jakobsen
authors.forename: Trine H
authors.initials: TH
authors.lastname: Mogensen
authors.forename: Søren R
authors.initials: SR
authors.lastname: Paludan
mesh_terms: D015967:Gene Expression Regulation, Viral / Q000235:genetics / Q000502:physiology; D015658:HIV Infections / Q000235:genetics / Q000378:metabolism*; D015497:HIV-1 / Q000235:genetics / Q000378:metabolism*; D006801:Humans; D050835:Interferon Regulatory Factors / Q000235:genetics / Q000378:metabolism*; D014779:Virus Replication / Q000235:genetics / Q000502:physiology*
chemical_list: D050835:Interferon Regulatory Factors