title: Patient-prosthesis mismatch has no influence on in-hospital mortality after aortic valve replacement.
abstract: OBJECTIVE
  To analyze the relationship between prosthetic aortic valve orifice and body surface area (Effective Orifice Area Index, EOAI) and in-hospital mortality after aortic valve replacement.
  
  
  METHODS
  A prospective study was conducted between October 2007 to September 2010, 536 patients underwent isolated aortic valve replacement (AVR) was recorded on preoperative, operative and postoperative data. Patient Prosthesis Mismatch (PPM) was classified by Effective Orifice Area Indexed (EOAI) by prosthetic valve area divided by body surface area as mild or no significance if the EOAI is greater than 0.85 cm2/m2, moderate if between 0.65 cm2/m2 and 0.85 cm2/m2, and severe if less than 0.65 cm2/m2. Statistical differences were analyzed by Chi-square and student t-test with p-value less than 0.05 considered significant.
  
  
  RESULTS
  There were 304 men, mean age was 60.98 years, mean valve orifice area 1.69 cm2, body surface area 1.60 m2, cross clamp time 1.13 hrs., bypass time 1.67 hrs. Mechanical valves were used in 274 patients (51.2%) and Bioprosthesis were used in 181 patients (48.8%). PPM was found in 33.7%, 6.7% was severe PPM, 27% was moderate PPM and 66.3% has no significant PPM Over all in-hospital mortality was 1.5%. There was no significant difference in hospital mortality between no PPM group, moderate PPM and severe PPM group (1.4% vs. 1.4% vs. 5.4%, p-value = 0.86).
  
  
  CONCLUSIONS
  In a large aortic valve surgery population, moderate and severe patient prosthesis mismatch occurred in 35.6% of patients but had no influence on in-hospital mortality.
authors.affiliation: Department of Cardiothoracic Surgery, Central Chest Institue of Thailand, Nonthaburi, Thailand. chaiwuty@yahoo.com
authors.forename: Chaiwut
authors.initials: C
authors.lastname: Yottasurodom
authors.forename: Kriengkrai
authors.initials: K
authors.lastname: Namthaisong
authors.forename: Pramote
authors.initials: P
authors.lastname: Porapakkham
authors.forename: Choosak
authors.initials: C
authors.lastname: Kasemsarn
authors.forename: Taweesak
authors.initials: T
authors.lastname: Chotivatanapong
authors.forename: Pradistchai
authors.initials: P
authors.lastname: Chaiseri
authors.forename: Suwannee
authors.initials: S
authors.lastname: Wongdit
authors.forename: Suwanna
authors.initials: S
authors.lastname: Yasotarin
mesh_terms: D001021:Aortic Valve / Q000473:pathology / Q000503:physiopathology / Q000601:surgery; D001024:Aortic Valve Stenosis / Q000473:pathology / Q000503:physiopathology / Q000601:surgery*; D001705:Bioprosthesis; D001830:Body Surface Area; D004452:Echocardiography; D019544:Equipment Failure Analysis; D005260:Female; D006350:Heart Valve Prosthesis / Q000009:adverse effects / Q000145:classification / Q000706:statistics & numerical data; D019918:Heart Valve Prosthesis Implantation / Q000009:adverse effects / Q000295:instrumentation / Q000379:methods / Q000706:statistics & numerical data; D017052:Hospital Mortality; D006801:Humans; D008297:Male; D008875:Middle Aged; D011475:Prosthesis Failure / Q000209:etiology; D017755:Prosthesis Fitting / Q000009:adverse effects / Q000379:methods / Q000706:statistics & numerical data; D016896:Treatment Outcome; D016277:Ventricular Function, Left