title: Resection of the epileptogenic lesion abolishes seizures and reduces inflammatory cytokines of patients with temporal lobe epilepsy.
abstract: Persistent neuroinflammation is implicated in the pathogenesis of seizures and neuronal degeneration of temporal lobe epilepsy (TLE). Circulating level of inflammatory cytokines was determined during inter-ictal period of 25 non-operated and 10 patients (OP) submitted to anterior temporal lobectomy. OP patients showed marked reduction of IL-1β, TNFα, MIP-1α, but not IL-6 and TGF-β1. Paired analysis done before and after lobectomy showed reduction of inflammatory cytokines but increased TGF-β1 levels, and lack of seizures for more than 6 months. Maintenance of high TGF-β1 and IL-6 cytokines in both groups suggests a role in down-regulation of neuroinflammation and promotion of brain tissue remodeling for neuronal reorganization.
authors.affiliation: Department of Cellular and Molecular Biology, Institute of Biology, Fluminense Federal University, Rio de Janeiro Federal University, Rio de Janeiro, Brazil. tquirico@vm.uff.br
authors.forename: Thereza
authors.initials: T
authors.lastname: Quirico-Santos
authors.forename: Isabella D'Andrea
authors.initials: ID
authors.lastname: Meira
authors.forename: Aline C
authors.initials: AC
authors.lastname: Gomes
authors.forename: Valeria C
authors.initials: VC
authors.lastname: Pereira
authors.forename: Moises
authors.initials: M
authors.lastname: Pinto
authors.forename: Marisa
authors.initials: M
authors.lastname: Monteiro
authors.forename: Jorge M
authors.initials: JM
authors.lastname: Souza
authors.forename: Soniza V
authors.initials: SV
authors.lastname: Alves-Leon
mesh_terms: D000293:Adolescent; D000328:Adult; D038481:Anterior Temporal Lobectomy / Q000379:methods*; D016207:Cytokines / Q000097:blood*; D004797:Enzyme-Linked Immunosorbent Assay; D004833:Epilepsy, Temporal Lobe / Q000097:blood / Q000601:surgery*; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D018709:Statistics, Nonparametric; D055815:Young Adult
chemical_list: D016207:Cytokines