title: Comparison of serum and urinary nephrin levels between normal pregnancies and severe preeclampsia.
abstract: OBJECTIVE
  To compare the levels of urinary excretion of nephrin in women experiencing either normotensive or severe preeclamptic pregnancies, and to examine the relationship between urinary nephrin levels and clinical parameters of preeclampsia.
  
  
  METHODS
  In a case control study we collected serum and urine specimens from women with normal pregnancy (n=30) and from women with severe preeclampsia (n=43). Serum nephrin levels and urinary nephrin concentrations were measured in all patients.
  
  
  RESULTS
  Both serum and urine concentrations of nephrin were significantly higher in the severe preeclamptic group than in the normal pregnancy group. In addition, we identified a significant relationship between urinary nephrin levels and urine protein concentrations in the severe preeclamptic group. Urine nephrin concentrations were also correlated with serum creatinine levels and with diastolic blood pressure in the severe preeclamptic group.
  
  
  CONCLUSIONS
  The positive correlations observed in this study suggest that urinary nephrin excretion might play an important role in the pathogenesis of proteinuria during preeclampsia and could be a good indicator of renal damage.
authors.affiliation: Division of Maternal-Fetal Medicine, Institute of Women's Life Medical Science, Department of Obstetrics and Gynecology, Yonsei University College of Medicine, Yonsei University Health System, Seoul, Republic of Korea.
authors.forename: Ga Hyun
authors.initials: GH
authors.lastname: Son
authors.forename: Ja Young
authors.initials: JY
authors.lastname: Kwon
authors.forename: Sanghoo
authors.initials: S
authors.lastname: Lee
authors.forename: Jimyeong
authors.initials: J
authors.lastname: Park
authors.forename: Young-Jin
authors.initials: YJ
authors.lastname: Kim
authors.forename: Bohyon
authors.initials: B
authors.lastname: Yun
authors.forename: Jung Hwa
authors.initials: JH
authors.lastname: Park
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000097:blood / Q000652:urine; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D008565:Membrane Proteins / Q000097:blood* / Q000652:urine*; D011225:Pre-Eclampsia / Q000097:blood* / Q000652:urine*; D011247:Pregnancy; D040281:Vascular Endothelial Growth Factor Receptor-1 / Q000097:blood
chemical_list: D015415:Biomarkers; D008565:Membrane Proteins; C113267:nephrin; C501162:FLT1 protein, human; D040281:Vascular Endothelial Growth Factor Receptor-1