title: Quorum sensing inhibitors: an overview.
abstract: Excessive and indiscriminate use of antibiotics to treat bacterial infections has lead to the emergence of multiple drug resistant strains. Most infectious diseases are caused by bacteria which proliferate within quorum sensing (QS) mediated biofilms. Efforts to disrupt biofilms have enabled the identification of bioactive molecules produced by prokaryotes and eukaryotes. These molecules act primarily by quenching the QS system. The phenomenon is also termed as quorum quenching (QQ). In addition, synthetic compounds have also been found to be effective in QQ. This review focuses primarily on natural and synthetic quorum sensing inhibitors (QSIs) with the potential for treating bacterial infections. It has been opined that the most versatile prokaryotes to produce QSI are likely to be those, which are generally regarded as safe. Among the eukaryotes, certain legumes and traditional medicinal plants are likely to act as QSIs. Such findings are likely to lead to efficient treatments with much lower doses of drugs especially antibiotics than required at present.
authors.affiliation: Microbial Biotechnology and Genomics, CSIR-Institute of Genomics and Integrative Biology (IGIB), Delhi University Campus, Mall Road, Delhi-110007, India. vckalia@igib.res.in
authors.forename: Vipin Chandra
authors.initials: VC
authors.lastname: Kalia
mesh_terms: D054742:Acyl-Butyrolactones / Q000737:chemistry / Q000494:pharmacology; D000818:Animals; D000900:Anti-Bacterial Agents / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D017756:Aquaculture; D059001:Aquatic Organisms / Q000378:metabolism / Q000382:microbiology; D001419:Bacteria / Q000187:drug effects / Q000472:pathogenicity; D018407:Bacterial Physiological Phenomena; D001426:Bacterial Proteins / Q000737:chemistry / Q000378:metabolism; D018441:Biofilms / Q000187:drug effects; D054884:Host-Pathogen Interactions; D006801:Humans; D010944:Plants / Q000378:metabolism / Q000382:microbiology; D053038:Quorum Sensing / Q000187:drug effects*; D012097:Repressor Proteins / Q000737:chemistry / Q000378:metabolism; D015534:Trans-Activators / Q000737:chemistry / Q000378:metabolism; D062065:Wastewater
chemical_list: D054742:Acyl-Butyrolactones; D000900:Anti-Bacterial Agents; D001426:Bacterial Proteins; D012097:Repressor Proteins; D015534:Trans-Activators; D062065:Wastewater; C080365:LasR protein, Pseudomonas aeruginosa; C088907:LuxO protein, Vibrio harveyi; C434259:QscR protein, Pseudomonas aeruginosa; C064778:LuxR autoinducer binding proteins