title: Vocal fold insufficiency: medialization laryngoplasty vs calcium hydroxylapatite microspheres (Radiesse Voice®).
abstract: CONCLUSIONS
  The choice of technique will depend on the glottic gap observed by stroboscopy, the alteration of the Voice Handicap Index (VHI) and the recorded values of harmonics-to-noise ratio (HNR), jitter and shimmer, and the general health, age and underlying pathology. There are statistically significant differences between the values of VHI, shimmer and jitter in favour of those cases operated on within 6 months of diagnosis. Alternatives are discussed.
  
  
  OBJECTIVE
  This study analysed and compared the functional, morphological and acoustic results, after surgery, through the techniques of medialization thyroplasty and infiltration of biomaterials to correct incomplete closure of the glottis.
  
  
  METHODS
  A total of 21 patients with dysphonia due to vocal fold insufficiency (13 women and 8 men) and ages ranging between 30 and 65 years (mean age 40.84, SD 12.5) were evaluated. The material used for augmentation surgery consisted of calcium hydroxylapatite microspheres. Measurements (VHI, jitter, shimmer and HNR) were performed before surgery and at 6 and 24 months post-intervention.
  
  
  RESULTS
  Overall, statistically significant differences were observed relating to measurements (p < 0.01) and surgical techniques (p < 0.05) analyzed. In particular, these differences were located in pairs pre-surgery - 6 months post-surgery and pre-surgery - post 24 months, in the four variables, and between the two techniques used in jitter (p = 0.008), HNR (p = 0.045) and VHI (p = 0.035).
authors.affiliation: Otolaryngology and Head and Neck Surgery Service, Reina Sofía University Hospital, Spain. ecantillo@telefonica.net
authors.forename: Enrique
authors.initials: E
authors.lastname: Cantillo-Baños
authors.forename: Alfredo
authors.initials: A
authors.lastname: Jurado-Ramos
authors.forename: José
authors.initials: J
authors.lastname: Gutiérrez-Jódas
authors.forename: Leopoldo
authors.initials: L
authors.lastname: Ariza-Vargas
mesh_terms: D000328:Adult; D017886:Durapatite / Q000008:administration & dosage*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D058753:Laryngoplasty / Q000379:methods*; D008297:Male; D008863:Microspheres; D008875:Middle Aged; D019736:Prostheses and Implants; D013018:Sound Spectrography; D014826:Vocal Cord Paralysis / Q000175:diagnosis / Q000209:etiology / Q000601:surgery*; D014833:Voice Quality
chemical_list: D017886:Durapatite