title: Synthesis and fluorescence study of a quaternized copolymer containing pyrene for DNA-hybridization detection.
abstract: Built-in detector: A quaternized copolymer containing pyrene is described, which can bind to single-stranded DNA by electrostatic interactions to form a novel complex probe for the detection of DNA hybridization through strengthened fluorescence quenching through its intercalation into double-stranded DNA (see figure).
authors.affiliation: School of Materials Science and Engineering, University of Science and Technology Beijing, Beijing 100083, China.
authors.forename: Lingye
authors.initials: L
authors.lastname: Yang
authors.forename: Min
authors.initials: M
authors.lastname: Zhao
authors.forename: Ruichen
authors.initials: R
authors.lastname: Zhang
authors.forename: Jie
authors.initials: J
authors.lastname: Dong
authors.forename: Ting
authors.initials: T
authors.lastname: Zhang
authors.forename: Xiaowei
authors.initials: X
authors.lastname: Zhan
authors.forename: Guojie
authors.initials: G
authors.lastname: Wang
mesh_terms: D000179:Acrylates / Q000737:chemistry; D020137:Base Pair Mismatch; D015374:Biosensing Techniques / Q000379:methods; D004247:DNA / Q000737:chemistry*; D005453:Fluorescence; D008689:Methacrylates / Q000138:chemical synthesis* / Q000737:chemistry; D015336:Molecular Probe Techniques; D009693:Nucleic Acid Hybridization / Q000379:methods*; D015345:Oligonucleotide Probes / Q000737:chemistry; D011721:Pyrenes / Q000737:chemistry*; D012313:RNA / Q000737:chemistry; D012680:Sensitivity and Specificity
chemical_list: D000179:Acrylates; D008689:Methacrylates; D015345:Oligonucleotide Probes; D011721:Pyrenes; D012313:RNA; D004247:DNA; C030984:pyrene; C049840:2-(dimethylamino)ethyl methacrylate