title: Dengue mortality in patients under 18 years old: an analysis from the health situation analysis of Thai population in 2010 project.
abstract: BACKGROUND
  Dengue is an important cause of morbidity and mortality in tropical and subtropical regions of the world. In Thailand, there has been no detailed research on mortality in children in terms of duration of admission and associated complications in the cases that died.
  
  
  OBJECTIVE
  To assess the burden of dengue in Thailand in 2010 and to analyze the complications in patients aged under 18 years who died.
  
  
  METHODS
  The authors described the mortality and complications of dengue fever and dengue hemorrhagic fever in patients under 18 years old using the information from the Health Situation Analysis of the Thai Population 2010 Project.
  
  
  RESULTS
  In 2010, the overall mortality of dengue in all age groups and in patients aged under 18 years were 0.3 and 0.6/ 100,000, respectively. The mortality rate was highest among children aged 6-12 years (0.8/100,000). Among the 8 children with dengue fever that died, the 2 most common complications were fluid electrolyte and acid-base imbalance and disseminated intravascular coagulation (DIC). The common complications among the 91 cases with dengue hemorrhagic fever that died included fluid electrolyte and acid-base imbalance, hepatic failure, respiratory failure, bacterial infection, DIC and renal failure.
  
  
  CONCLUSIONS
  Early diagnosis, careful management of fluid therapy, awareness of hepatic and renal impairment and early treatment of co-infection should decrease mortality of dengue hemorrhagic fever
authors.affiliation: Department of Pediatrics, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand. paglum@kku.ac.th
authors.forename: Pagakrong
authors.initials: P
authors.lastname: Lumbiganon
authors.forename: Pope
authors.initials: P
authors.lastname: Kosalaraksa
authors.forename: Kaewjai
authors.initials: K
authors.lastname: Thepsuthammarat
authors.forename: Sumitr
authors.initials: S
authors.lastname: Sutra
mesh_terms: D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D003715:Dengue / Q000401:mortality*; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D012307:Risk Factors; D013785:Thailand / Q000453:epidemiology