title: Multi-slice myelin water imaging for practical clinical applications at 3.0 T.
abstract: Myelin water imaging is a promising, noninvasive technique for evaluating white matter diseases such as multiple sclerosis and other leukoencephalopathies (LE), and monitoring myelination in early childhood. Unfortunately, poor image quality and a long acquisition time are major obstacles to practical clinical applications. In this study, a novel postprocessing method with an efficient multi-slice acquisition scheme, called T2 spectrum analysis using a weighted regularized non-negative least squares algorithm and nonlocal mean filter (T2SPARC), is presented to overcome these obstacles and achieve a shorter acquisition time, higher image quality, and large volume coverage. In vivo results from healthy volunteers and a patient with LE showed that the T2SPARC method can generate robust and high-quality myelin water fraction maps of 10 slices within 11 min. This method also yields some useful byproducts such as intra- and extracellular water fraction and long T2 tissue water fraction maps, which can quantify lesions in different brain diseases.
authors.affiliation: Department of Radiological Sciences, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.
authors.forename: Junyu
authors.initials: J
authors.lastname: Guo
authors.forename: Qing
authors.initials: Q
authors.lastname: Ji
authors.forename: Wilburn E
authors.initials: WE
authors.lastname: Reddick
mesh_terms: D000328:Adult; D000465:Algorithms; D001931:Brain Mapping / Q000379:methods; D006801:Humans; D056784:Leukoencephalopathies / Q000175:diagnosis*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D015203:Reproducibility of Results; D013057:Spectrum Analysis
keywords: T2 spectrum analysis; leukoencephalopathy; myelin water fraction; myelin water imaging; quantitative MRI; white matter