title: Anxiolytic and hypnotic effects in mice of roasted coffee bean volatile compounds.
abstract: To clarify the relationship between the volatile compounds present in roasted coffee beans and psychological stress, we investigated the stress-reducing potential of coffee volatiles in mice using a variety of behavioral pharmacology methods. In the elevated plus-maze test, exposure to coffee volatiles increased the time spent in and the number of entries into the open arms without increasing spontaneous locomotor activity. Pentobarbital-induced sleep time was prolonged by volatile exposure. No significant effects were detected in the open-field or forced-swim tests. These results suggest that coffee volatiles lower the arousal level and exert anti-anxiety-like, stress-reducing effects in mice.
authors.affiliation: Department of Foods and Human Nutrition, Faculty of Human Life Sciences, Notre Dame Seishin University, 2-16-9 Ifuku-cho, Kita-Ku, Okayama 700-8516, Japan. yhayashi@post.ndsu.ac.jp
authors.forename: Yasushi
authors.initials: Y
authors.lastname: Hayashi
authors.forename: Saki
authors.initials: S
authors.lastname: Sogabe
authors.forename: Yukio
authors.initials: Y
authors.lastname: Hattori
authors.forename: Junichi
authors.initials: J
authors.lastname: Tanaka
mesh_terms: D000818:Animals; D014151:Anti-Anxiety Agents / Q000494:pharmacology*; D001522:Behavior, Animal / Q000187:drug effects*; D040503:Coffea / Q000737:chemistry*; D006993:Hypnotics and Sedatives / Q000494:pharmacology*; D008297:Male; D018782:Maze Learning / Q000187:drug effects; D051379:Mice; D008813:Mice, Inbred ICR; D012639:Seeds / Q000737:chemistry*; D013315:Stress, Psychological; D055549:Volatile Organic Compounds / Q000494:pharmacology
chemical_list: D014151:Anti-Anxiety Agents; D006993:Hypnotics and Sedatives; D055549:Volatile Organic Compounds