title: S(N)2' reaction of allylic difluorides with lithium amides and thiolates.
abstract: The synthesis of monofluoroalkenes using an S(N)2' reaction of lithium amides derived from aromatic amines or lithium thiolates with 3,3-difluoropropenes is reported. This transformation features the use of fluoride as a leaving group.
authors.affiliation: Canada Research Chair in Organic and Medicinal Chemistry, Département de chimie, Université Laval, 1045 avenue de la Médecine, Québec, Québec G1V 0A6, Canada.
authors.forename: Maxime
authors.initials: M
authors.lastname: Bergeron
authors.forename: David
authors.initials: D
authors.lastname: Guyader
authors.forename: Jean-François
authors.initials: JF
authors.lastname: Paquin
mesh_terms: D000475:Alkenes / Q000138:chemical synthesis* / Q000737:chemistry*; D000577:Amides / Q000737:chemistry*; D020650:Combinatorial Chemistry Techniques; D006845:Hydrocarbons, Fluorinated / Q000138:chemical synthesis* / Q000737:chemistry*; D008094:Lithium / Q000737:chemistry*; D015394:Molecular Structure; D009942:Organometallic Compounds / Q000737:chemistry*; D013438:Sulfhydryl Compounds / Q000737:chemistry*
chemical_list: D000475:Alkenes; D000577:Amides; D006845:Hydrocarbons, Fluorinated; D009942:Organometallic Compounds; D013438:Sulfhydryl Compounds; D008094:Lithium