title: Toxicity in mice of lectin ebulin f present in dwarf Elderberry (Sambucus ebulus L.).
abstract: Dwarf elder fruits (Sambucus ebulus) contain the ribosome-inactivating lectin ebulin f structurally related to ricin. We investigated intraperitoneal toxicity of ebulin f in mice and found that it triggers specific derangement of the intestines. Ebulin f was much less toxic than ricin to mice when administered intraperitoneally. The targets were cells of the intestinal crypts, which underwent apoptosis. Small intestine crypts were more sensitive than large intestine crypts.
authors.affiliation: Departamento de Nutrición y Bromatología, Facultad de Medicina, Universidad de Valladolid, E-47005, Valladolid, Spain.
authors.forename: Pilar
authors.initials: P
authors.lastname: Jiménez
authors.forename: Manuel
authors.initials: M
authors.lastname: Gayoso
authors.forename: Jesús
authors.initials: J
authors.lastname: Tejero
authors.forename: Patricia
authors.initials: P
authors.lastname: Cabrero
authors.forename: Damián
authors.initials: D
authors.lastname: Córdoba-Díaz
authors.forename: José E
authors.initials: JE
authors.lastname: Basterrechea
authors.forename: Tomás
authors.initials: T
authors.lastname: Girbés
mesh_terms: D000818:Animals; D017209:Apoptosis / Q000187:drug effects; D001835:Body Weight / Q000187:drug effects; D005638:Fruit; D007274:Injections, Intraperitoneal; D007421:Intestine, Small / Q000473:pathology; D053208:Kaplan-Meier Estimate; D037102:Lectins / Q000737:chemistry* / Q000633:toxicity*; D051379:Mice; D054790:Ribosome Inactivating Proteins, Type 2 / Q000737:chemistry* / Q000633:toxicity*; D012276:Ricin / Q000633:toxicity; D027923:Sambucus / Q000737:chemistry*; D016019:Survival Analysis
chemical_list: D037102:Lectins; D054790:Ribosome Inactivating Proteins, Type 2; C581455:ebulin f, Sambucus ebulus; D012276:Ricin