title: [Effect of antagonists of 5-HT receptors on modulation with serotonin of synaptical activity of projectional neurons of dorsolateral nucleus of rat amygdala].
abstract: The work deals with study of role of different serotonin (5-HT) receptor types in the process of synaptic activity modulation of rat dorsolateral amygdale projection neurons with serotonin. The selective antagonist of 5-HT1,2 receptors methylsergide maleate was shown to suppress the 5-HT inhibitory action on amplitude of the postsynaptic currents evoked by glutamate and GABA, whereas the antagonist of 5-HT3,4 receptors SDZ202-557 produced no effect on the above-mentioned 5-HT action. The obtained action indicates that the 5-HT modulatory effect on the projectional neuron synaptic inputs is mediated by 5-HT receptors of the 1 and 2 types.
authors.forename: I S
authors.initials: IS
authors.lastname: Masalov
authors.forename: E A
authors.initials: EA
authors.lastname: Tsvetkov
authors.forename: E I
authors.initials: EI
authors.lastname: Lokshina
authors.forename: N P
authors.initials: NP
authors.lastname: Veselkin
mesh_terms: D000679:Amygdala / Q000378:metabolism*; D000818:Animals; D005260:Female; D018698:Glutamic Acid / Q000378:metabolism; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D011985:Receptors, Serotonin / Q000378:metabolism*; D059326:Serotonergic Neurons / Q000378:metabolism*; D012701:Serotonin / Q000378:metabolism; D017366:Serotonin Receptor Agonists / Q000494:pharmacology*; D009435:Synaptic Transmission / Q000187:drug effects*; D005680:gamma-Aminobutyric Acid / Q000378:metabolism
chemical_list: D011985:Receptors, Serotonin; D017366:Serotonin Receptor Agonists; D012701:Serotonin; D018698:Glutamic Acid; D005680:gamma-Aminobutyric Acid