title: Darier-White disease in siblings responding to isotretinoin.
abstract: Darier-White disease (keratosis follicularis) is a rare disorder of keratinization involving the epidermis, mucous membranes, and nails. It is said to occur as a result of mutation in the ATP2A2 gene located on chromosome 12q23-24.1. In this article we present the case of two brothers with exacerbations of Darier-White disease who responded very well to systemic retinoids without any side effects within 2 weeks of commencing treatment.
authors.affiliation: Department of Dermatology, Venereology and Leprosy, Father Muller Medical College, Kankanady, Mangalore - 575 002, India.
authors.forename: Ramesh M
authors.initials: RM
authors.lastname: Bhat
authors.forename: Krithi Raviraj
authors.initials: KR
authors.lastname: Ullal
authors.forename: Anita Caroline
authors.initials: AC
authors.lastname: Pinto
authors.forename: D
authors.initials: D
authors.lastname: Sukumar
keywords: Darier-White disease; isotretinoin; keratosis follicularis