title: A genome-wide sib-pair linkage analysis of ossification of the posterior longitudinal ligament of the spine.
abstract: Ossification of the posterior longitudinal ligament of the spine (OPLL) is a common musculoskeletal disease among people after middle age. The OPLL presents with serious neurological abnormalities due to compression of the spinal cord and nerve roots. The OPLL is caused by genetic and environment factors; however, its etiology and pathogenesis still remain to be elucidated. To determine the susceptibility loci for OPLL, we performed a genome-wide linkage study using 214 affected sib-pairs of Japanese. In stratification analyses for definite cervical OPLL, we found loci with suggestive linkage on 1p21, 2p22-2p24, 7q22, 16q24 and 20p12. Fine mapping using additional markers detected the highest non-parametric linkage score (3.43, P = 0.00027) at D20S894 on chromosome 20p12 in a subgroup that had no complication of diabetes mellitus. Our result would shed a new light on genetic aspects of OPLL.
authors.affiliation: Laboratory for Bone and Joint Diseases, Center for Genomic Medicine, RIKEN, 4-6-1 Shirokanedai, Minato-ku, Tokyo, 108-8639, Japan.
authors.forename: Tatsuki
authors.initials: T
authors.lastname: Karasugi
authors.forename: Masahiro
authors.initials: M
authors.lastname: Nakajima
authors.forename: Katsunori
authors.initials: K
authors.lastname: Ikari
authors.forename: Takashi
authors.initials: T
authors.lastname: Tsuji
authors.forename: Morio
authors.initials: M
authors.lastname: Matsumoto
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Chiba
authors.forename: Kenzo
authors.initials: K
authors.lastname: Uchida
authors.forename: Yoshiharu
authors.initials: Y
authors.lastname: Kawaguchi
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Mizuta
authors.forename: Naoshi
authors.initials: N
authors.lastname: Ogata
authors.forename: Motoki
authors.initials: M
authors.lastname: Iwasaki
authors.forename: Shingo
authors.initials: S
authors.lastname: Maeda
authors.forename: Takuya
authors.initials: T
authors.lastname: Numasawa
authors.forename: Kuniyoshi
authors.initials: K
authors.lastname: Abumi
authors.forename: Tsuyoshi
authors.initials: T
authors.lastname: Kato
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Ozawa
authors.forename: Toshihiko
authors.initials: T
authors.lastname: Taguchi
authors.forename: Takashi
authors.initials: T
authors.lastname: Kaito
authors.forename: Masashi
authors.initials: M
authors.lastname: Neo
authors.forename: Masashi
authors.initials: M
authors.lastname: Yamazaki
authors.forename: Nobuaki
authors.initials: N
authors.lastname: Tadokoro
authors.forename: Munehito
authors.initials: M
authors.lastname: Yoshida
authors.forename: Shinnosuke
authors.initials: S
authors.lastname: Nakahara
authors.forename: Kenji
authors.initials: K
authors.lastname: Endo
authors.forename: Shiro
authors.initials: S
authors.lastname: Imagama
authors.forename: Satoru
authors.initials: S
authors.lastname: Demura
authors.forename: Kimiaki
authors.initials: K
authors.lastname: Sato
authors.forename: Atsushi
authors.initials: A
authors.lastname: Seichi
authors.forename: Shoichi
authors.initials: S
authors.lastname: Ichimura
authors.forename: Masahiko
authors.initials: M
authors.lastname: Watanabe
authors.forename: Kei
authors.initials: K
authors.lastname: Watanabe
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Nakamura
authors.forename: Kanji
authors.initials: K
authors.lastname: Mori
authors.forename: Hisatoshi
authors.initials: H
authors.lastname: Baba
authors.forename: Yoshiaki
authors.initials: Y
authors.lastname: Toyama
authors.forename: Shiro
authors.initials: S
authors.lastname: Ikegawa
mesh_terms: D002877:Chromosomes, Human / Q000235:genetics; D005260:Female; D008040:Genetic Linkage; D015894:Genome, Human / Q000235:genetics*; D006801:Humans; D008297:Male; D008875:Middle Aged; D017887:Ossification of Posterior Longitudinal Ligament / Q000235:genetics*; D020161:Physical Chromosome Mapping; D035781:Siblings