title: Assessment of risk factors related to suicide attempts in patients with bipolar disorder.
abstract: We compared the characteristics of patients with bipolar disorder with and without a history of suicide attempts to identify the risk factors of suicide in this disorder. Among 212 patients with bipolar disorder, 44 (21.2%) patients had histories of suicide attempts. Suicide attempters were younger and more likely to be diagnosed with bipolar II. The variables that differentiated those who did from those who did not attempt suicide included age at first contact, lifetime history of antidepressant use, major depressive episode, mixed episode, auditory hallucinations, rapid cycling, the number of previous mood episodes, age of first depressive episode, and age of first psychotic symptoms. Strong predictors of suicide attempts were younger age at onset, lifetime history of auditory hallucinations, and history of antidepressant use. Antecedent depressive episodes and psychotic symptoms predicted the first suicide attempt in patients with bipolar disorder. This study could help clinicians to understand the major risk factors of suicidal behavior in bipolar disorder.
authors.affiliation: Department of Psychiatry and Behavioral Science, Seoul National University College of Medicine, Seoul, Republic of Korea.
authors.forename: Joo Yun
authors.initials: JY
authors.lastname: Song
authors.forename: Han Young
authors.initials: HY
authors.lastname: Yu
authors.forename: Se Hyun
authors.initials: SH
authors.lastname: Kim
authors.forename: Samuel S-H
authors.initials: SS
authors.lastname: Hwang
authors.forename: Hyun-Sang
authors.initials: HS
authors.lastname: Cho
authors.forename: Yong Sik
authors.initials: YS
authors.lastname: Kim
authors.forename: Kyooseob
authors.initials: K
authors.lastname: Ha
authors.forename: Yong Min
authors.initials: YM
authors.lastname: Ahn
mesh_terms: D000328:Adult; D017668:Age of Onset; D000928:Antidepressive Agents / Q000627:therapeutic use; D001714:Bipolar Disorder / Q000175:diagnosis / Q000523:psychology*; D003865:Major Depressive Disorder / Q000175:diagnosis / Q000523:psychology; D005260:Female; D006212:Hallucinations / Q000175:diagnosis / Q000523:psychology; D006801:Humans; D008297:Male; D011569:Psychiatric Status Rating Scales; D056910:Republic of Korea; D012307:Risk Factors; D013406:Suicide, Attempted / Q000517:prevention & control / Q000523:psychology*; D055815:Young Adult
chemical_list: D000928:Antidepressive Agents