title: Ventral free oral mucous membrane graft for bulbar urethral stricture.
abstract: The use of oral mucous membrane graft onlay urethroplasty represents the most widespread method of bulbar urethral stricture repair. We investigated the short term result of oral mucous membrane graft placed on the ventral surface for management of bulbar urethral stricture. Patients with Bulbar urethral stricture of any length, infection free urinary tract and informed consent for oral mucosa harvesting and urethroplasty were selected for study. We enrolled 108 cases of bulbar urethral stricture patients from January 2004 to July 2009. The mean ± SD preoperative maximum flow rate of 5.2 ± 2.6 ml/sec and mean ± SD PVR 87 ± 58.3 ml were treated by substitution urethroplasty with oral mucous membrane by a single surgical team in a private hospital. Causes of stricture were trauma 26(24.1%), infection 58(53.7%), catheter induced 8(7.4%), post TURP 11(10.2%) and unknown 5(4.6%). Oral mucous membrane was harvested from the cheek or from the inner side of lower lip. Defect of the urethra displayed by longitudinal ventral urethrotomy and the graft was sutured over the edges of the incised urethral mucosa over a 14 Fr latex Foley's catheter. Spongiosum tissue was closed over the graft. Pericatheter urethrogram was performed in all cases to check for the anastomotic leakage and the Catheter was removed after 2 weeks of the procedure. After removal of catheter uroflowmetry & ultrasound scan of bladder were performed to estimate the maximum flow rate and post voidal residue. The patient was followed-up every 3 months with uroflowmetry & ultrasonography. The median (range) age of the patients was 32(21-72) years. Mean follow up period was 36 months (range 12-54). Mean ± SD stricture length was 3.7 ± 2.6 cm. The overall success rate was 91.7%. Mean ± SD flow rate was 23 ± 4.2 ml/sec, mean ± SD post void residue was 25 ± 15.5 ml and patient quality of life (QOL) was excellent in almost all patients. Overall complications were seen in 9(8.3%) cases. Of which, restricture occurred in 6 patients; periurethral fistulae seen in 2 cases and per urethral bleeding in 1 patient. No significant complications were observed at the donor site. Oral numbness and mild discomfort complained by 67.6% patients which were managed by reassurance only. In our experience ventral placement of oral mucous membrane graft along with spongioplasty is a very easy procedure with very encouraging short term result.
authors.affiliation: National Institute of Cancer Research and Hospital, Mohakhali, Dhaka, Bangladesh.
authors.forename: M E
authors.initials: ME
authors.lastname: Haque
authors.forename: M A
authors.initials: MA
authors.lastname: Rahman
authors.forename: M F
authors.initials: MF
authors.lastname: Islam
authors.forename: F H
authors.initials: FH
authors.lastname: Siddique
authors.forename: M M
authors.initials: MM
authors.lastname: Uddin
authors.forename: M I
authors.initials: MI
authors.lastname: Khondoker
authors.forename: I
authors.initials: I
authors.lastname: Kaiser
authors.forename: O
authors.initials: O
authors.lastname: Siddiqui
authors.forename: M M
authors.initials: MM
authors.lastname: Karim
authors.forename: P
authors.initials: P
authors.lastname: Saha
authors.forename: M A
authors.initials: MA
authors.lastname: Salam
mesh_terms: D000328:Adult; D000368:Aged; D058752:Free Tissue Flaps; D006801:Humans; D008297:Male; D008875:Middle Aged; D009061:Mouth Mucosa / Q000637:transplantation*; D011183:Postoperative Complications; D014525:Urethral Stricture / Q000601:surgery*; D055815:Young Adult