title: Low-dose "metronomic chemotherapy" with oral cyclophosphamide and methotrexate in metastatic breast cancer: a case report of extraordinarily prolonged clinical benefit.
abstract: We report the case of a 34-year-old woman affected by breast cancer that had metastasized to the bone. She had been treated with oral cyclophosphamide and methotrexate (metronomic chemotherapy) and achieved 3.5 years of clinical remission. To our knowledge, this is the first description of such a prolonged response to therapy. This case report adds weight to known data on metronomic treatment and supports further investigation of this therapy.
authors.affiliation: Humanitas Cancer Center, Istituto Clinico Humanitas, Istituto Di Ricovero e Cura a Carattere Scientifico, Via Manzoni 56, 20089 Rozzano, Milan, Italy.
authors.forename: G
authors.initials: G
authors.lastname: Masci
authors.forename: A
authors.initials: A
authors.lastname: Losurdo
authors.forename: C
authors.initials: C
authors.lastname: Gandini
authors.forename: I
authors.initials: I
authors.lastname: Garassino
authors.forename: L
authors.initials: L
authors.lastname: di Tommaso
authors.forename: R
authors.initials: R
authors.lastname: Torrisi
authors.forename: M
authors.initials: M
authors.lastname: Zuradelli
authors.forename: A
authors.initials: A
authors.lastname: Santoro