title: Local hematopoietic renin-angiotensin system in myeloid versus lymphoid hematological neoplastic disorders.
abstract: There is preliminary evidence that the local renin-angiotensin system (RAS) could affect neoplastic hematopoiesis. The aim of this study is to search messenger RNA (mRNA) expressions of the essential RAS elements in myeloid and lymphoid hematological neoplastic disorders. Forty-six patients with newly diagnosed myeloid (AML, biphenotypic leukemia, CML) or lymphoid (CLL, NHL, B-ALL, T-ALL) hematological disorders were included in the study. In the lymphoid group, the median expression values of RENIN, ACE1, ACE2 and ANGIOTENSINOGEN (ANGTS) mRNAs were 1.96%, 0.42%, 0.00% and 0.00%, respectively; in the myeloid group, 0.73%, 1.55%, 0.04% and 0.006%, respectively. In the lymphoid group, RENIN levels were significantly higher (p = 0.001), whereas ACE1 and ACE2 levels were significantly higher in the myeloid group (p values were 0.013 and 0.010, respectively). ANGTS levels were similar in both groups. In patients with non-ALL lymphoid malignancies, RENIN expressions were significantly higher when compared to ALL patients (p = 0.004). All patients with active disease had significantly higher RENIN mRNA expression levels than patients without active disease (2.03% vs 0.30%) (p = 0.034). The result of our present study indicates that the activities of local RAS may differ in distinct disease states such as leukemia and lymphomas.
authors.affiliation: 1Hacettepe University, Department of Internal Medicine, Hematology Unit, Turkey.
authors.forename: Burak
authors.initials: B
authors.lastname: Uz
authors.forename: Suzin Catal
authors.initials: SC
authors.lastname: Tatonyan
authors.forename: Muge
authors.initials: M
authors.lastname: Sayitoglu
authors.forename: Yucel
authors.initials: Y
authors.lastname: Erbilgin
authors.forename: Ozden Hatirnaz
authors.initials: OH
authors.lastname: Ng
authors.forename: Yahya
authors.initials: Y
authors.lastname: Buyukasik
authors.forename: Nilgun
authors.initials: N
authors.lastname: Sayinalp
authors.forename: Salih
authors.initials: S
authors.lastname: Aksu
authors.forename: Hakan
authors.initials: H
authors.lastname: Goker
authors.forename: Osman I
authors.initials: OI
authors.lastname: Ozcebe
authors.forename: Ugur
authors.initials: U
authors.lastname: Ozbek
authors.forename: Ibrahim C
authors.initials: IC
authors.lastname: Haznedaroglu
mesh_terms: D000808:Angiotensinogen / Q000235:genetics / Q000378:metabolism; D015972:Gene Expression Regulation, Neoplastic; D019337:Hematologic Neoplasms / Q000378:metabolism*; D006410:Hematopoiesis; D006801:Humans; D008223:Lymphoma / Q000378:metabolism*; D007703:Peptidyl-Dipeptidase A / Q000235:genetics / Q000378:metabolism; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D012083:Renin / Q000235:genetics / Q000378:metabolism; D012084:Renin-Angiotensin System
chemical_list: D012333:RNA, Messenger; D000808:Angiotensinogen; D007703:Peptidyl-Dipeptidase A; D012083:Renin
keywords: ACE; Hematopoiesis; leukemia; lymphoma; renin; renin-angiotensin system