title: G-cimp status prediction of glioblastoma samples using mRNA expression data.
abstract: Glioblastoma Multiforme (GBM) is a tumor with high mortality and no known cure. The dramatic molecular and clinical heterogeneity seen in this tumor has led to attempts to define genetically similar subgroups of GBM with the hope of developing tumor specific therapies targeted to the unique biology within each of these subgroups. Recently, a subset of relatively favorable prognosis GBMs has been identified. These glioma CpG island methylator phenotype, or G-CIMP tumors, have distinct genomic copy number aberrations, DNA methylation patterns, and (mRNA) expression profiles compared to other GBMs. While the standard method for identifying G-CIMP tumors is based on genome-wide DNA methylation data, such data is often not available compared to the more widely available gene expression data. In this study, we have developed and evaluated a method to predict the G-CIMP status of GBM samples based solely on gene expression data.
authors.affiliation: Neuro-Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.
authors.forename: Mehmet
authors.initials: M
authors.lastname: Baysan
authors.forename: Serdar
authors.initials: S
authors.lastname: Bozdag
authors.forename: Margaret C
authors.initials: MC
authors.lastname: Cam
authors.forename: Svetlana
authors.initials: S
authors.lastname: Kotliarova
authors.forename: Susie
authors.initials: S
authors.lastname: Ahn
authors.forename: Jennifer
authors.initials: J
authors.lastname: Walling
authors.forename: Jonathan K
authors.initials: JK
authors.lastname: Killian
authors.forename: Holly
authors.initials: H
authors.lastname: Stevenson
authors.forename: Paul
authors.initials: P
authors.lastname: Meltzer
authors.forename: Howard A
authors.initials: HA
authors.lastname: Fine
mesh_terms: D001932:Brain Neoplasms / Q000235:genetics*; D016000:Cluster Analysis; D018899:CpG Islands / Q000235:genetics*; D019175:DNA Methylation / Q000235:genetics*; D030541:Databases, Genetic; D015972:Gene Expression Regulation, Neoplastic; D005909:Glioblastoma / Q000235:genetics*; D006801:Humans; D053208:Kaplan-Meier Estimate; D008957:Models, Genetic; D025341:Principal Component Analysis; D012333:RNA, Messenger / Q000235:genetics; D015203:Reproducibility of Results
chemical_list: D012333:RNA, Messenger