title: [Relationship of polymorphisms of AhR -1661G/A with GSTP1 -313A/G and susceptibility to endometriosis].
abstract: OBJECTIVE
  To investigate the association of polymorphisms of arylhydrocarbon receptor (AhR)-1661G/A with glutathione S-transferase pi (GSTP1) -313A/G and the susceptibility to endometriosis in southern Han Chinese.
  
  
  METHODS
  Total of 432 endometriosis patients undergoing laparoscopic or laparotomy surgery matched with 493 patients with fallopian tube ligation, tubal recanalization, laparoscopic hydrotubation, benign ovarian tumor and teratoma surgeries without endometriosis as control group were enrolled in this study. The single nucleotide polymorphism (SNP) of AhR -1661G/A and GSTP1 -313A/G were detected by using a fluorescent quantitative PCR-based high resolution melting (HRM).
  
  
  RESULTS
  The numbers of combined genotypes AhR -1661G/A and GSTP1 -313A/G were 120 patients with AG + AA, 64 patients with AG + AG, 8 patients with AG + GG, 109 patients with GG + AA, 84 patients with GG + AG, 4 patients with GG + GG, 31 patients with AA + AA, 10 patients with AA + AG, 1 patient with AA + GG at endometriosis group and 131 patients with AG + AA, 68 patients with AG + AG, 6 patients with AG + GG, 157 patients with GG + AA, 66 patients with GG + AG, 4 patients with GG + GG, 35 patients with AA + AA, 20 patients with AA + AG, 3 patients with AA + GG at endometriosis group. There was no statistically different frequencies of genotypes between endometriosis group and control group (χ(2) = 12.558, P = 0.128). Compared with genotype GG + AA, the risk of endometriosis with genotype GG + AG was increased 1.833 time (95%CI: 1.233 - 2.274).
  
  
  CONCLUSIONS
  The combined genotype GG + AG [from AhR -1661G/A (GG) and GSTP1 -313A/G (AG)] might be related with susceptibility to endometriosis.
authors.affiliation: Department of Obstetrics and Gynecology, Guangzhou Red Cross Hospital, Guangzhou 510220, China.
authors.forename: Yu-feng
authors.initials: YF
authors.lastname: Wang
authors.forename: Li-li
authors.initials: LL
authors.lastname: Zong
authors.forename: Ting
authors.initials: T
authors.lastname: Mao
authors.forename: Yi-feng
authors.initials: YF
authors.lastname: Wang
authors.forename: Yong-gui
authors.initials: YG
authors.lastname: Fu
authors.forename: Jun
authors.initials: J
authors.lastname: Zeng
authors.forename: Xing-qiang
authors.initials: XQ
authors.lastname: Rao
mesh_terms: D000328:Adult; D044466:Asian People; D016022:Case-Control Studies; D017931:DNA Primers; D004715:Endometriosis / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D051549:Glutathione S-Transferase pi / Q000235:genetics*; D006801:Humans; D016133:Polymerase Chain Reaction / Q000379:methods; D020641:Polymorphism, Single Nucleotide; D018336:Receptors, Aryl Hydrocarbon / Q000235:genetics*; D012307:Risk Factors
chemical_list: D017931:DNA Primers; D018336:Receptors, Aryl Hydrocarbon; C496556:GSTP1 protein, human; D051549:Glutathione S-Transferase pi