title: Dietary resveratrol prevents Alzheimer's markers and increases life span in SAMP8.
abstract: Resveratrol is a polyphenol that is mainly found in grapes and red wine and has been reported to be a caloric restriction (CR) mimetic driven by Sirtuin 1 (SIRT1) activation. Resveratrol increases metabolic rate, insulin sensitivity, mitochondrial biogenesis and physical endurance, and reduces fat accumulation in mice. In addition, resveratrol may be a powerful agent to prevent age-associated neurodegeneration and to improve cognitive deficits in Alzheimer's disease (AD). Moreover, different findings support the view that longevity in mice could be promoted by CR. In this study, we examined the role of dietary resveratrol in SAMP8 mice, a model of age-related AD. We found that resveratrol supplements increased mean life expectancy and maximal life span in SAMP8 and in their control, the related strain SAMR1. In addition, we examined the resveratrol-mediated neuroprotective effects on several specific hallmarks of AD. We found that long-term dietary resveratrol activates AMPK pathways and pro-survival routes such as SIRT1 in vivo. It also reduces cognitive impairment and has a neuroprotective role, decreasing the amyloid burden and reducing tau hyperphosphorylation.
authors.affiliation: Unitat de Farmacologia i Farmacognòsia, Facultat de Farmàcia, Institut de Biomedicina (IBUB), Centros de Investigación Biomédica en Red de Enfermedades Neurodegenerativas (CIBERNED), Av. Joan XXIII s/n., 08028, Barcelona, Spain.
authors.forename: David
authors.initials: D
authors.lastname: Porquet
authors.forename: Gemma
authors.initials: G
authors.lastname: Casadesús
authors.forename: Sergi
authors.initials: S
authors.lastname: Bayod
authors.forename: Alberto
authors.initials: A
authors.lastname: Vicente
authors.forename: Anna M
authors.initials: AM
authors.lastname: Canudas
authors.forename: Jordi
authors.initials: J
authors.lastname: Vilaplana
authors.forename: Carme
authors.initials: C
authors.lastname: Pelegrí
authors.forename: Coral
authors.initials: C
authors.lastname: Sanfeliu
authors.forename: Antoni
authors.initials: A
authors.lastname: Camins
authors.forename: Mercè
authors.initials: M
authors.lastname: Pallàs
authors.forename: Jaume
authors.initials: J
authors.lastname: del Valle
mesh_terms: D000375:Aging; D000544:Alzheimer Disease / Q000178:diet therapy* / Q000378:metabolism / Q000503:physiopathology; D000818:Animals; D015415:Biomarkers / Q000378:metabolism*; D015153:Blotting, Western; D031204:Caloric Restriction; D003071:Cognition / Q000187:drug effects; D019587:Dietary Supplements; D004195:Disease Models, Animal; D004791:Enzyme Inhibitors / Q000008:administration & dosage; D007150:Immunohistochemistry; D008136:Longevity / Q000187:drug effects*; D051379:Mice; D000077185:Resveratrol; D012264:Ribonucleotide Reductases / Q000037:antagonists & inhibitors; D013267:Stilbenes / Q000008:administration & dosage*
chemical_list: D015415:Biomarkers; D004791:Enzyme Inhibitors; D013267:Stilbenes; D012264:Ribonucleotide Reductases; D000077185:Resveratrol