title: Involvement of glucocorticoid receptor on hyperpyrexia  induced by methamphetamine administration.
abstract: We have investigated the involvement of glucocorticoid on methamphetamine (MA) induced hyperpyrexia using a bio-telemetric system. A significant level of hyperpyrexia was observed in MA administered rats. In contrast, increase of body temperature was suppressed by adrenalectomy or by the administration of RU-486, an antagonist of the glucocorticoid receptor. These data suggest that the glucocorticoid receptor may be involved in hyperpyrexia induced by MA.
  
  
  BACKGROUND
  methamphetamine - hyperpyrexia - glucocorticoid - corticosterone.
authors.affiliation: Department of Anesthesia, Hyogo College of Medicine, Nishinomiya, Japan.
authors.forename: S
authors.initials: S
authors.lastname: Yoshida
authors.forename: H
authors.initials: H
authors.lastname: Kinoshita
authors.forename: T
authors.initials: T
authors.lastname: Tatara
authors.forename: C
authors.initials: C
authors.lastname: Tashiro
authors.forename: M
authors.initials: M
authors.lastname: Nishiguchi
authors.forename: H
authors.initials: H
authors.lastname: Ouchi
authors.forename: T
authors.initials: T
authors.lastname: Minami
authors.forename: S
authors.initials: S
authors.lastname: Hishida
mesh_terms: D000315:Adrenalectomy; D000818:Animals; D001831:Body Temperature / Q000187:drug effects; D000697:Central Nervous System Stimulants / Q000506:poisoning*; D003345:Corticosterone / Q000097:blood; D005334:Fever / Q000139:chemically induced*; D008297:Male; D008694:Methamphetamine / Q000506:poisoning*; D015735:Mifepristone / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D011965:Receptors, Glucocorticoid / Q000378:metabolism*
chemical_list: D000697:Central Nervous System Stimulants; D011965:Receptors, Glucocorticoid; D015735:Mifepristone; D008694:Methamphetamine; D003345:Corticosterone