title: [Cognitive disorders in the early rehabilitation period of ischemic stroke and possibilities of their treatment with neuromidin].
abstract: Cognitive functions were assessed in 116 patients, aged from 18 to 84 years, in the early rehabilitation period of the first ischemic stroke of hemispheric localization and in 44 patients with cerebrovascular disorders without history of stroke. MMSE, FAB, CDT, 5 words' test, the Schulte test, verbal fluency test, CES-D were administered. The statistically significant decrease in cognitive functions was seen in the index group compared with the control one. The level of cognitive impairment was correlated with the severity of neurological deficit and age and was aggravated by depression. Neuromidin (ipidacrinum) was used in the treatment of 31 patients in incremental doses (intramuscular injections of 10 mg/day during the first two weeks and later--60 mg/day during 40 days per os). As a result, the significant increase in cognitive function with the recovery of attention, memory and lobe functions was noted.
authors.forename: L V
authors.initials: LV
authors.lastname: Pustokhanova
authors.forename: E M
authors.initials: EM
authors.lastname: Morozova
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000634:Aminoquinolines / Q000008:administration & dosage / Q000627:therapeutic use*; D001288:Attention / Q000187:drug effects; D002800:Cholinesterase Inhibitors / Q000627:therapeutic use*; D003072:Cognition Disorders / Q000175:diagnosis / Q000188:drug therapy* / Q000209:etiology; D005260:Female; D006801:Humans; D008297:Male; D008568:Memory / Q000187:drug effects; D008875:Middle Aged; D009483:Neuropsychological Tests; D020521:Stroke / Q000150:complications* / Q000523:psychology; D000071939:Stroke Rehabilitation; D055815:Young Adult
chemical_list: D000634:Aminoquinolines; D002800:Cholinesterase Inhibitors; C049860:amiridine