title: Aptamer-capped multifunctional mesoporous strontium hydroxyapatite nanovehicle for cancer-cell-responsive drug delivery and imaging.
abstract: A novel cancer-cells-triggered controlled-release gadolinium-doped luminescent and mesoporous strontium hydroxyapatite nanorods (designated as Gd:SrHap nanorods) system using cell-type-specific aptamers as caps has been constructed. Aptamers behave as a dual-functional molecule that acts as not only a lid but also a targeted molecular that can be used in an effective way for therapeutically special cancer cells. After incubated with cancer cells, for example, MCF-7 cells, the doxorubicin-loaded and aptamer-capped Gd:SrHap nanorods (designated as Gd:SrHap-Dox-aptamer) can be internalized into MCF-7 cells, resulting in the pore opening and drug releasing. Furthermore, the high biocompatibility and biodegradability Gd:SrHap nanorods with blue autofluorescence and paramagnetism could serve as a good contrast agent of targeting fluorescence and magnetic resonance imaging. We envision that this Gd:SrHap system could play a significant role in developing new generations of site-selective, controlled-release delivery and interactive sensory nanodevices.
authors.affiliation: State Key Laboratory of Rare Earth Resource Utilization, Laboratory of Chemical Biology, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 130022, PR China.
authors.forename: Zhenhua
authors.initials: Z
authors.lastname: Li
authors.forename: Zhen
authors.initials: Z
authors.lastname: Liu
authors.forename: Meili
authors.initials: M
authors.lastname: Yin
authors.forename: Xinjian
authors.initials: X
authors.lastname: Yang
authors.forename: Qinghai
authors.initials: Q
authors.lastname: Yuan
authors.forename: Jinsong
authors.initials: J
authors.lastname: Ren
authors.forename: Xiaogang
authors.initials: X
authors.lastname: Qu
mesh_terms: D000818:Animals; D052157:Aptamers, Nucleotide / Q000494:pharmacology*; D004317:Doxorubicin / Q000494:pharmacology; D004337:Drug Carriers / Q000138:chemical synthesis*; D004587:Electrophoresis, Agar Gel; D005682:Gadolinium / Q000494:pharmacology; D006801:Humans; D006882:Hydroxyapatites / Q000737:chemistry*; D061986:MCF-7 Cells; D008279:Magnetic Resonance Imaging; D051379:Mice; D041681:NIH 3T3 Cells; D036103:Nanotechnology; D043942:Nanotubes / Q000737:chemistry; D013324:Strontium / Q000737:chemistry*
chemical_list: D052157:Aptamers, Nucleotide; D004337:Drug Carriers; D006882:Hydroxyapatites; C076185:strontium hydroxyapatite; D004317:Doxorubicin; D005682:Gadolinium; D013324:Strontium