title: A biocatalytic hydrogenation of carboxylic acids.
abstract: The hyperthermophile Pyrococcus furiosus catalyses the hydrogenation of a broad range of carboxylic acids selectively to the corresponding primary alcohols. Other functional groups such as isolated C=C-double bonds are not touched. The chemoselectivity of the carboxylate reduction may be directed towards aldehydes by simple medium engineering.
authors.affiliation: Delft University of Technology, Department of Biotechnology, Julianalaan 136, 2628BL Delft, The Netherlands.
authors.forename: Yan
authors.initials: Y
authors.lastname: Ni
authors.forename: Peter-Leon
authors.initials: PL
authors.lastname: Hagedoorn
authors.forename: Jian-He
authors.initials: JH
authors.lastname: Xu
authors.forename: Isabel W C E
authors.initials: IW
authors.lastname: Arends
authors.forename: Frank
authors.initials: F
authors.lastname: Hollmann
mesh_terms: D000438:Alcohols / Q000378:metabolism; D000447:Aldehydes / Q000378:metabolism; D055162:Biocatalysis; D002264:Carboxylic Acids / Q000737:chemistry / Q000378:metabolism*; D006865:Hydrogenation; D010084:Oxidation-Reduction; D020027:Pyrococcus furiosus / Q000378:metabolism
chemical_list: D000438:Alcohols; D000447:Aldehydes; D002264:Carboxylic Acids