title: Critical roles of RNA-binding proteins in miRNA biogenesis in Arabidopsis.
abstract: MicroRNAs (miRNAs) are key regulators of gene expression and play critical roles in modulating metabolism, development and physiology in animals and plants. miRNA levels are transcriptionally and post-transcriptionally controlled for their proper function. Recent studies have shown that RNA-binding proteins play important roles in producing miRNAs by affecting the accurate and/or efficient processing of precursors of miRNAs. Many of these RNA-binding proteins also have roles in general RNA metabolism, indicating potential connections between miRNA biogenesis and other RNA metabolism. Here, we focus on the function of several RNA-binding proteins in miRNA biogenesis in Arabidopsis.
authors.affiliation: Center for Plant Science Innovation & School of Biological Sciences; University of Nebraska; Lincoln, NE USA.
authors.forename: Guodong
authors.initials: G
authors.lastname: Ren
authors.forename: Bin
authors.initials: B
authors.lastname: Yu
mesh_terms: D000483:Alleles; D017360:Arabidopsis / Q000235:genetics / Q000378:metabolism*; D029681:Arabidopsis Proteins / Q000235:genetics / Q000378:metabolism; D002135:Calcium-Binding Proteins / Q000235:genetics / Q000378:metabolism; D002352:Carrier Proteins / Q000235:genetics / Q000378:metabolism; D018506:Gene Expression Regulation, Plant; D017343:Genes, Plant; D036341:Intercellular Signaling Peptides and Proteins / Q000235:genetics / Q000378:metabolism; D008565:Membrane Proteins / Q000235:genetics / Q000378:metabolism; D035683:MicroRNAs / Q000235:genetics / Q000378:metabolism*; D011485:Protein Binding; D025941:Protein Interaction Mapping; D012323:RNA Processing, Post-Transcriptional; D018749:RNA, Plant / Q000235:genetics / Q000378:metabolism*; D034741:RNA, Small Interfering / Q000235:genetics / Q000378:metabolism; D016601:RNA-Binding Proteins / Q000235:genetics / Q000378:metabolism; D000072099:Serrate-Jagged Proteins
chemical_list: D029681:Arabidopsis Proteins; C454128:CBP20 protein, Arabidopsis; D002135:Calcium-Binding Proteins; D002352:Carrier Proteins; C514692:DAWDLE protein, Arabidopsis; C420966:HYL1 protein, Arabidopsis; D036341:Intercellular Signaling Peptides and Proteins; D008565:Membrane Proteins; D035683:MicroRNAs; D018749:RNA, Plant; D034741:RNA, Small Interfering; D016601:RNA-Binding Proteins; C000606277:SE protein, Arabidopsis; D000072099:Serrate-Jagged Proteins; C506680:TOUGH protein, Arabidopsis
keywords: Arabidopsis; CBP80/CBP20; DCL1; DDL; HYL1; RNA-binding protein; SE; TOUGH; miRNA biogenesis