title: Is isolated systolic hypertension worse than combined systolic/diastolic hypertension?
abstract: New developments in cardiovascular translational sciences have significantly advanced our understanding of the endovascular biology of blood pressure. Reductions in vascular elasticity and vessel compliance of conduit arteries are key components of both ISH and SDH. Vascular changes from the matrix metalloproteinase family of enzymes are involved in arterial wall remodeling and vascular stiffness. This new translational information helps further our understanding of both ISH and SDH.
authors.affiliation: San Antonio Cardiovascular Proteomics Center, the Barshop Institute for Longevity and Aging Studies, the Division of Geriatrics, Gerontology and Palliative Medicine, The University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA.
authors.forename: Yonggang
authors.initials: Y
authors.lastname: Ma
authors.forename: Andriy
authors.initials: A
authors.lastname: Yabluchanskiy
authors.forename: Merry L
authors.initials: ML
authors.lastname: Lindsey
authors.forename: Robert J
authors.initials: RJ
authors.lastname: Chilton
mesh_terms: D003971:Diastole / Q000502:physiology*; D004730:Endothelium, Vascular / Q000503:physiopathology*; D006801:Humans; D006973:Hypertension / Q000503:physiopathology*; D020780:Matrix Metalloproteinase 9 / Q000502:physiology; D013599:Systole / Q000502:physiology*; D057170:Translational Research, Biomedical; D061205:Vascular Calcification / Q000503:physiopathology
chemical_list: D020780:Matrix Metalloproteinase 9