title: Identification of gold nanoparticle-resistant mutants of Saccharomyces cerevisiae suggests a role for respiratory metabolism in mediating toxicity.
abstract: Positively charged gold nanoparticles (0.8-nm core diameter) reduced yeast survival, but not growth, at a concentration of 10 to 100 μg/ml. Among 17 resistant deletion mutants isolated in a genome-wide screen, highly significant enrichment was observed for respiration-deficient mutants lacking genes encoding proteins associated with the mitochondrion.
authors.affiliation: Department of Food Science and Technology, Oregon State University, Corvallis, Oregon, USA.
authors.forename: Mark R
authors.initials: MR
authors.lastname: Smith
authors.forename: Matthew G
authors.initials: MG
authors.lastname: Boenzli
authors.forename: Vihangi
authors.initials: V
authors.lastname: Hindagolla
authors.forename: Jun
authors.initials: J
authors.lastname: Ding
authors.forename: John M
authors.initials: JM
authors.lastname: Miller
authors.forename: James E
authors.initials: JE
authors.lastname: Hutchison
authors.forename: Jeffrey A
authors.initials: JA
authors.lastname: Greenwood
authors.forename: Hagai
authors.initials: H
authors.lastname: Abeliovich
authors.forename: Alan T
authors.initials: AT
authors.lastname: Bakalinsky
mesh_terms: D025141:Drug Resistance, Fungal; D017353:Gene Deletion; D006046:Gold / Q000633:toxicity*; D053858:Metabolic Networks and Pathways; D050296:Microbial Viability / Q000187:drug effects; D053758:Nanoparticles / Q000633:toxicity*; D012441:Saccharomyces cerevisiae / Q000187:drug effects* / Q000235:genetics* / Q000502:physiology
chemical_list: D006046:Gold