title: [Age-dependent changes in phospholipid content and neutral lipid contents in aging].
abstract: Oxidative processes and lipid metabolism in young (3-4 months) and old (25-28 months) were studied. The increase of the rate of reactions of free radical oxidation of lipids (hydroperoxides, and malondialdehyde) and the accumulation of products of oxidative modification of proteins was recorded in mitochondrial fraction of rat brain. The accumulation of nitric oxide in the mitochondria and the oxidation products leads to the development of oxidative stress. Investigation of the lipid spectrum in old rat brains showed that aging was accompanied by a change in the qualitative and quantitative content of phospholipids. A change in the metabolism of neutral glycolipids leads to a decrease in the content of cerebrosides and sulfoserobrosides. At the same time an increase in sphingosine (a product of hidrolytic decomposition of neutral glycolipids) was observed. The key role of lipid metabolism in age pathologies was noticed.
authors.forename: L M
authors.initials: LM
authors.lastname: Ovsepian
authors.forename: G S
authors.initials: GS
authors.lastname: Kazarian
authors.forename: A A
authors.initials: AA
authors.lastname: Akopdzhanian
authors.forename: M V
authors.initials: MV
authors.lastname: L'vov
mesh_terms: D000375:Aging / Q000378:metabolism*; D000818:Animals; D001921:Brain / Q000378:metabolism / Q000473:pathology; D005609:Free Radicals / Q000378:metabolism; D006861:Hydrogen Peroxide / Q000378:metabolism*; D050356:Lipid Metabolism; D008315:Malondialdehyde / Q000378:metabolism*; D010084:Oxidation-Reduction; D018384:Oxidative Stress / Q000502:physiology; D010743:Phospholipids / Q000378:metabolism*; D051381:Rats; D013367:Submitochondrial Particles
chemical_list: D005609:Free Radicals; D010743:Phospholipids; D008315:Malondialdehyde; D006861:Hydrogen Peroxide