title: There is no evidence for an association between the serotonin receptor 3A gene C178T polymorphism and tardive dyskinesia in Korean schizophrenia patients.
abstract: BACKGROUND
  Tardive dyskinesia (TD) is a potential adverse effect of long-term treatment with antipsychotics. Previous studies have suggested a link between brain serotonergic systems and TD vulnerability. A recent report described that a serotonin 3 receptor (5-HTR3) agonist induced rhythmic movements in mice with complete paraplegia. Furthermore, it has been reported that the 5-HTR3 antagonist ondansetron is efficacious in the treatment of Gilles de la Tourette syndrome (GTS).
  
  
  OBJECTIVE
  The aim of the present study was to determine whether the 5-HTR3A gene C178T polymorphism is associated with antipsychotic-induced TD in Korean schizophrenia patients.
  
  
  METHODS
  We investigated 280 Korean schizophrenia patients. Subjects with TD (n = 105) and without TD (n = 175) were matched for antipsychotic drug exposure and other relevant variables.
  
  
  RESULTS
  The distributions of genotypic (chi-squared = 3.55, p = 0.169) and allelic (chi-squared = 0.40, p = 0.528) frequencies did not differ between patients with and without TD. The total score on the Abnormal Involuntary Movement Scale also did not differ between the two genotype groups (F = 0.94, p = 0.391).
  
  
  CONCLUSIONS
  The findings of the present study do not support the involvement of the 5-HTR3A gene C178T polymorphism in TD in Korean schizophrenia subjects.
authors.affiliation: Department of Psychiatry, Gachon University, School of Medicine, Incheon, Korea.
authors.forename: Seung-Gul
authors.initials: SG
authors.lastname: Kang
authors.forename: Heon-Jeong
authors.initials: HJ
authors.lastname: Lee
authors.forename: Ho-Kyoung
authors.initials: HK
authors.lastname: Yoon
authors.forename: Sung Nam
authors.initials: SN
authors.lastname: Cho
authors.forename: Young-Min
authors.initials: YM
authors.lastname: Park
authors.forename: Leen
authors.initials: L
authors.lastname: Kim
mesh_terms: D014150:Antipsychotic Agents / Q000009:adverse effects* / Q000627:therapeutic use; D016022:Case-Control Studies; D004409:Dyskinesia, Drug-Induced / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D007723:Korea; D008297:Male; D011110:Polymorphism, Genetic; D044406:Receptors, Serotonin, 5-HT3 / Q000235:genetics*; D012559:Schizophrenia / Q000188:drug therapy*
chemical_list: D014150:Antipsychotic Agents; D044406:Receptors, Serotonin, 5-HT3