title: IsoDGR-tagged albumin: a new αvβ3 selective carrier for nanodrug delivery to tumors.
abstract: A new cyclic peptide containing the isoDGR motif that, after coupling to albumin, selectively binds αvβ3, an integrin overexpressed in the tumor vasculature. IsoDGR-tagged albumin binds tumor vessels and can be exploited as a carrier for the preparation of tumor vasculature-selective nanomedicines, such as gold nanoparticles (Au) carrying tumor necrosis factor α (TNF), a potent vascular damaging agent.
authors.affiliation: Division of Molecular Oncology, San Raffaele Scientific Institute, Milan 20132, Italy.
authors.forename: Flavio
authors.initials: F
authors.lastname: Curnis
authors.forename: Angelina
authors.initials: A
authors.lastname: Sacchi
authors.forename: Renato
authors.initials: R
authors.lastname: Longhi
authors.forename: Barbara
authors.initials: B
authors.lastname: Colombo
authors.forename: Anna
authors.initials: A
authors.lastname: Gasparri
authors.forename: Angelo
authors.initials: A
authors.lastname: Corti
mesh_terms: D006046:Gold / Q000737:chemistry; D006801:Humans; D039302:Integrin alphaVbeta3 / Q000008:administration & dosage / Q000737:chemistry*; D053768:Metal Nanoparticles / Q000737:chemistry; D009369:Neoplasms / Q000378:metabolism*; D014409:Tumor Necrosis Factor-alpha / Q000737:chemistry
chemical_list: D039302:Integrin alphaVbeta3; D014409:Tumor Necrosis Factor-alpha; D006046:Gold