title: Nodal recurrence of sinonasal cancer: does the risk of cervical relapse justify a prophylactic neck treatment?
abstract: BACKGROUND
  Sinonasal cancers are rare and no high-level evidence exists to determine their optimal management. Prophylactic neck treatment issue remains controversial. The aim of this study was to analyze the pattern of neck failure and to identify any prognostic factors that may influence neck control.
  
  
  METHODS
  A retrospective review of 155 consecutive patients treated for sinonasal malignancy, without prophylactic neck treatment, between 1995 and 2005 at tertiary cancer center was performed. Demographic, clinical, morphological and pathological parameters were correlated with oncologic outcomes.
  
  
  RESULTS
  Eight out of 155 patients (5%) presented initially with neck node metastasis. Complete remission was obtained for 133 patients after treatment completion. During follow up, 16 out of 133 patients (12%) were affected with regional recurrence. Neck failure occurred in 8 out of 51 patients with local failure and in 8 out of 82 patients locally controlled. Isolated nodal failure was observed in 5 patients initially cN0 out of 133 (3.8%) representing 7.3% of all recurrences and 3 of them underwent successful salvage therapy. None of the tested factors were significantly associated with neck control (p>0.05). Lymph node at diagnosis time was significantly and independently associated with poor survival (p=0.0012).
  
  
  CONCLUSIONS
  Isolated neck relapse, when local control is achieved, is rare and salvage treatment is effective. Routine prophylactic neck treatment has little interest. However, this approach could be profitable to few selected patients, who remain to be defined. Further investigations are needed.
authors.affiliation: Head and Neck Department, Institut Gustave Roussy, Villejuif, France. mirghani_fr@yahoo.fr
authors.forename: Haïtham
authors.initials: H
authors.lastname: Mirghani
authors.forename: Dana
authors.initials: D
authors.lastname: Hartl
authors.forename: Geoffrey
authors.initials: G
authors.lastname: Mortuaire
authors.forename: Gian Luca
authors.initials: GL
authors.lastname: Armas
authors.forename: Anne
authors.initials: A
authors.lastname: Aupérin
authors.forename: Dominique
authors.initials: D
authors.lastname: Chevalier
authors.forename: Jean Louis
authors.initials: JL
authors.lastname: Lefebvre
mesh_terms: D006801:Humans; D008207:Lymphatic Metastasis / Q000517:prevention & control*; D009333:Neck / Q000473:pathology*; D009364:Neoplasm Recurrence, Local; D009669:Nose Neoplasms / Q000473:pathology*; D012189:Retrospective Studies; D016879:Salvage Therapy