title: Histone H3 lysine 4 methylation revisited.
abstract: Since its discovery more than a decade ago, H3K4 methylation has become synonymous with transcription. We only now have begun to realize that the distinct states of H3K4 methylation have unique distributions and specialized roles in other chromatin-related processes. Here, I discuss recent findings addressing their regulation and functions.
authors.affiliation: Department of Molecular Biology and Biochemistry; Rutgers, The State University of New Jersey, Nelson Laboratories A233, Piscataway, NJ, USA. kusch@biology.rutgers.edu
authors.forename: Thomas
authors.initials: T
authors.lastname: Kusch
mesh_terms: D000818:Animals; D002843:Chromatin / Q000378:metabolism; D011495:Histone-Lysine N-Methyltransferase / Q000737:chemistry / Q000378:metabolism; D006657:Histones / Q000737:chemistry / Q000378:metabolism*; D006801:Humans; D008745:Methylation
chemical_list: D002843:Chromatin; D006657:Histones; D011495:Histone-Lysine N-Methyltransferase
keywords: H3K4 methylation; KMT2; MLL; Set1; Trr; Trx; chromatin; transcription