title: Clinical diagnosis in preclinical stage of Alzheimer's disease.
abstract: Preclinical diagnosis of Alzheimer's disease using biomarkers has become an area of great interest for both clinicians and researchers because, among other advantages, this would increase the response to new disease-modifying drugs. However, difficulties with compliance and economic costs marginalize many countries worldwide that do not have access to this new type of diagnosis. The opportunity exists to refine the conventional clinical method, without using biomarkers, to attempt an earlier diagnosis as there is information that supports the potential utility of a focused clinical interview, observation of gait and use of more demanding memory tests.
authors.affiliation: Cognitive Neurology and Dementia Unit, Neurology Service, Hospital del Salvador and Geriatrics Section, Clinical Hospital University of Chile, Santiago, Chile. pfuentes8410@gmail.com
authors.forename: Patricio
authors.initials: P
authors.lastname: Fuentes
mesh_terms: D000544:Alzheimer Disease / Q000145:classification / Q000175:diagnosis* / Q000191:economics; D015415:Biomarkers / Q000032:analysis; D003071:Cognition; D042241:Early Diagnosis; D005684:Gait; D006801:Humans; D007407:Interviews as Topic; D008568:Memory; D009460:Neurologic Examination; D009483:Neuropsychological Tests
chemical_list: D015415:Biomarkers