title: Biology of PIWI-interacting RNAs: new insights into biogenesis and function inside and outside of germlines.
abstract: PIWI-interacting RNAs (piRNAs) are endogenous small noncoding RNAs that act as guardians of the genome, protecting it from invasive transposable elements in the germline. Animals lacking piRNA functions show defects in gametogenesis and exhibit sterility. Their descendants are also predisposed to inheriting mutations. Thus, the piRNA pathway has evolved to repress transposons post-transcriptionally and/or transcriptionally. A growing number of studies on piRNAs have investigated piRNA-mediated gene silencing, including piRNA biogenesis. However, piRNAs remain the most enigmatic among all of the silencing-inducing small RNAs because of their complexity and uniqueness. Although piRNAs have been previously suggested to be germline-specific, recent studies have shown that piRNAs also play crucial roles in nongonadal cells. Furthermore, piRNAs have also recently been shown to have roles in multigenerational epigenetic phenomena in worms. The purpose of this review is to highlight new piRNA factors and novel insights in the piRNA world.
authors.affiliation: Graduate School of Science, The University of Tokyo, Tokyo 113-0033, Japan.
authors.forename: Hirotsugu
authors.initials: H
authors.lastname: Ishizu
authors.forename: Haruhiko
authors.initials: H
authors.lastname: Siomi
authors.forename: Mikiko C
authors.initials: MC
authors.lastname: Siomi
mesh_terms: D000818:Animals; D005786:Gene Expression Regulation; D005854:Germ Cells / Q000378:metabolism; D006801:Humans; D009154:Mutation; D017434:Protein Structure, Tertiary; D012323:RNA Processing, Post-Transcriptional; D034741:RNA, Small Interfering / Q000096:biosynthesis* / Q000235:genetics / Q000378:metabolism*
chemical_list: D034741:RNA, Small Interfering