title: [Impact of thymosin-alpha1 on reproduction of herpes simplex virus in cell system and on course of acute experimental infection in mice].
abstract: The article contains results of laboratory and experimental investigation carried out for comparative estimation of antiviral activity of thymosin-alpha1 (Ta1) against herpes simplex virus (HSV).   It was demonstrated that administration of tymosin-alpha1 in cultivated in vitro cellular system had been inoculated with HSV provided inhibition of HSV reproduction and defense of cells of HSV cytopathogenic action. Moreover Ta1 ability to inhibit HSV reproduction in cell was comparable with the same ability of human alpha-interferon.  Besides it was demonstrated that Ta1 parenteral administration to mice infected with HSV leaded to reduce of mice morbidity percent and prolonged of their survival rate. Ta1 ability to depress experimental viral infection development was higher than same ability of acyclovir.
authors.forename: M K
authors.initials: MK
authors.lastname: Mamedov
authors.forename: S M
authors.initials: SM
authors.lastname: Safarova
authors.forename: A E
authors.initials: AE
authors.lastname: Dadasheva
mesh_terms: D000818:Animals; D002460:Cell Line; D005347:Fibroblasts / Q000187:drug effects / Q000821:virology; D006801:Humans; D016898:Interferon-alpha / Q000008:administration & dosage; D051379:Mice; D018139:Simplexvirus / Q000187:drug effects* / Q000472:pathogenicity; D000077596:Thymalfasin; D013947:Thymosin / Q000008:administration & dosage / Q000031:analogs & derivatives*; D014779:Virus Replication / Q000187:drug effects*
chemical_list: D016898:Interferon-alpha; D013947:Thymosin; D000077596:Thymalfasin