title: A new program of kidney transplantation from donors after cardiac death in Spain.
abstract: Despite the high rate of kidney transplantation in Spain, a disparity still exists between the numbers of donors and waiting-list patients. Donors after circulatory death (DCD) have been propagated as a promising approach to reduce the donor kidney shortage. In Europe most of the countries use controlled DCD, but in Spain, mainly uncontrolled DCD are harvested and until 2010 at only four institutions. In January 2010, we began a program of donation after uncontrolled DCD (Maastricht type II; unsuccessful resuscitation). The aim of this observational study was to describe our preliminary results. The numbers of recovered and transplanted organs per DCD were 27. There were no cases of primary nonfunction, but delayed graft function was present in 85% of recipients. Despite this impairment, about 75% of patients reached a serum creatinine below 2 mg/dL in the second month, with 1-year graft and patient survivals of 85% and 100%. Although, our preliminary results with a not very long follow-up and small number of patients suggested that utilization of DCD should be expanded because this type of donor increases the number of cases and opportunities of end-stage renal disease patients to reduce the waiting times for transplantation.
authors.affiliation: Hospital Universitario Virgen de las Nieves, Grenada, Spain. degraciaguindo@gmail.com
authors.forename: M C
authors.initials: MC
authors.lastname: de Gracia
authors.forename: J M
authors.initials: JM
authors.lastname: Osorio
authors.forename: J M
authors.initials: JM
authors.lastname: Pérez-Villares
authors.forename: P
authors.initials: P
authors.lastname: Galindo
authors.forename: M C
authors.initials: MC
authors.lastname: Ruiz
authors.forename: A
authors.initials: A
authors.lastname: Pérez-Marfil
authors.forename: J
authors.initials: J
authors.lastname: Bravo
authors.forename: A
authors.initials: A
authors.lastname: Osuna
mesh_terms: D015415:Biomarkers / Q000097:blood; D003404:Creatinine / Q000097:blood; D051799:Delayed Graft Function / Q000097:blood / Q000209:etiology / Q000503:physiopathology; D046148:Donor Selection; D005260:Female; D006084:Graft Rejection / Q000097:blood / Q000209:etiology / Q000503:physiopathology; D006085:Graft Survival; D006331:Heart Diseases / Q000401:mortality*; D006801:Humans; D007676:Kidney Failure, Chronic / Q000601:surgery*; D016030:Kidney Transplantation / Q000009:adverse effects / Q000401:mortality; D008297:Male; D008875:Middle Aged; D015397:Program Evaluation; D012189:Retrospective Studies; D013030:Spain; D013997:Time Factors; D014019:Tissue Donors / Q000600:supply & distribution*; D009927:Tissue and Organ Procurement; D016896:Treatment Outcome; D014850:Waiting Lists
chemical_list: D015415:Biomarkers; D003404:Creatinine