title: Comparison of whole body diffusion weighted magnetic resonance imaging and somatostatin receptor scintigraphy for oncogenic osteomalacia.
abstract: OBJECTIVE
  To compare the accuracy of whole body diffusion weighted magnetic resonance imaging (WB-DWI) with that of somatostatin receptor scintigraphy (SRS) in the detection and localization of the lesions in patients with oncogenic osteomalacia (OOM).
  
  
  METHODS
  Totally 6 patients with clinically suspected oncogenic osteomalacia were enrolled. All of them underwent WB-DWI and SRS within 2 weeks to evaluate the possible presence of tumors that lead to osteomalacia. Surgical and pathological findings were considered as the gold standard. The sensitivity, specificity, and accuracy were calculated.
  
  
  RESULTS
  Pathology confirmed the diagnosis of two soft tissue tumors (including 1 angiolipoma and 1 mesenchymal tumor) and one bone tumor of malignant neurofibroma. The sensitivity, specificity, and accuracy in the identification of lesions in patients with oncogenic osteomalacia were 33.33%, 100%, 66.67% for WB-DWI and 33.33%, 66.67%, 50% for SRS (P>0.05).
  
  
  CONCLUSIONS
  For adult patients with osteomalacia, WB-DWI and SRS can provide mutually supportive data and be used for identifying potential oncogenic osteomalacia.
authors.affiliation: Department of Radiology, PUMC Hospital, CAMS and PUMC, Beijing 100730, China.
authors.forename: Shuo
authors.initials: S
authors.lastname: Li
authors.forename: Hua-dan
authors.initials: HD
authors.lastname: Xue
authors.forename: Yan
authors.initials: Y
authors.lastname: Jiang
authors.forename: Wei-bo
authors.initials: WB
authors.lastname: Xia
authors.forename: Hong-li
authors.initials: HL
authors.lastname: Jing
authors.forename: Li-bo
authors.initials: LB
authors.lastname: Chen
authors.forename: Fei
authors.initials: F
authors.lastname: Sun
authors.forename: Zheng-yu
authors.initials: ZY
authors.lastname: Jin
mesh_terms: D000328:Adult; D001859:Bone Neoplasms / Q000175:diagnosis*; D038524:Diffusion Magnetic Resonance Imaging / Q000379:methods*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009372:Neoplasms, Connective Tissue / Q000175:diagnosis*; D010018:Osteomalacia; D010257:Paraneoplastic Syndromes; D017481:Receptors, Somatostatin; D012680:Sensitivity and Specificity; D051598:Whole Body Imaging / Q000379:methods*; D055815:Young Adult
chemical_list: D017481:Receptors, Somatostatin