title: Evaluation of the oncogenic risk of diffuse gastric polyposis. A case report.
abstract: Benign polyps of the stomach undergo malignant transformation at a rate correlating to the histological type and size of the proliferative lesion. We report a case of a 50-year-old Caucasian woman, affected by a diffuse gastric polyposis of both hyperplastic and adenomatous type. At endoscopy polyps were more than 1,000, scattered over the entire gastric cavity. The patient underwent total gastrectomy. The perilesional gastric mucosa was characterized by the presence of either atrophic or metaplastic areas and by a mild dysplasia. A single tubulo-villous adenomatous polyp was also present in the ascending tract of the colon. The absence of both high-grade dysplastic lesions and outbreaks of neoplastic transformation well correlated with the histochemical and molecular features, confirming the highly proliferative pattern of the polyps in the lack of signs of malignant progression.
authors.affiliation: Department of Medico-Surgical Sciences and Biotechnologies, University of Rome Sapienza, Hospital "A. Fiorini", Terracina, Latina, Italy.
authors.forename: Erasmo
authors.initials: E
authors.lastname: Spaziani
authors.forename: Marcello
authors.initials: M
authors.lastname: Picchio
authors.forename: Annalisa
authors.initials: A
authors.lastname: Di-Filippo
authors.forename: Piero
authors.initials: P
authors.lastname: Narilli
authors.forename: Luca
authors.initials: L
authors.lastname: Pacini
authors.forename: Valentina
authors.initials: V
authors.lastname: Moretti
authors.forename: Pierino
authors.initials: P
authors.lastname: Lucarelli
authors.forename: Francesco
authors.initials: F
authors.lastname: De-Angelis
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Ragona
authors.forename: Vincenzo
authors.initials: V
authors.lastname: Petrozza
mesh_terms: D000236:Adenoma / Q000737:chemistry / Q000473:pathology*; D001284:Atrophy; D014408:Biomarkers, Tumor / Q000032:analysis; D002471:Cell Transformation, Neoplastic; D004273:DNA, Neoplasm / Q000032:analysis; D005260:Female; D005743:Gastrectomy; D006801:Humans; D006965:Hyperplasia; D008679:Metaplasia; D008875:Middle Aged; D009378:Neoplasms, Multiple Primary / Q000737:chemistry / Q000473:pathology* / Q000601:surgery; D011127:Polyps / Q000737:chemistry / Q000473:pathology* / Q000601:surgery; D012306:Risk; D013274:Stomach Neoplasms / Q000737:chemistry / Q000473:pathology* / Q000601:surgery
chemical_list: D014408:Biomarkers, Tumor; D004273:DNA, Neoplasm