title: Cell-derived microparticles and vascular pregnancy complications: a systematic and comprehensive review.
abstract: OBJECTIVE
  To assess current studies on the relationship between cell-derived microparticles (cMP) and recurrent miscarriages (RM) and pre-eclampsia (PE), and review the relationships between cMP and inflammatory and clot pathways, antiphospholipid antibodies (aPL), cytokines, and pregnancy complications.
  
  
  METHODS
  Systematic and comprehensive review of the literature from January 2000 to January 2012.
  
  
  METHODS
  Vall d'Hebron University Hospital.
  
  
  METHODS
  Women with recurrent miscarriages or PE, healthy nonpregnant women, and healthy pregnant women.
  
  
  METHODS
  None.
  
  
  METHODS
  Comparison of cMP numbers and types among groups.
  
  
  RESULTS
  Platelet and endothelial cMP are increased in women with normal pregnancies compared with nonpregnant healthy women. Only five case-control studies regarding cMP and RM and 16 on cMP and PE were found to match our objective. Three of five articles referring to RM showed differences in cMP numbering, and 13 of 16 on cMP and PE showed differences in some type of cMP compared with controls.
  
  
  CONCLUSIONS
  Cell-derived microparticles were raised in normal pregnancy. Recurrent miscarriage seems to be related to endothelial and platelet cell activation and/or consumption. An increase in almost all cMP types was observed in PE. A relationship between cMP and endothelial activation and proinflammatory status seems to exist.
authors.affiliation: Aging and Systemic Autoimmune Disease Unit, Department of Internal Medicine I, Vall d'Hebron University Hospital, Barcelona, Spain. 16297jar@comb.es
authors.forename: Jaume
authors.initials: J
authors.lastname: Alijotas-Reig
authors.forename: Carles
authors.initials: C
authors.lastname: Palacio-Garcia
authors.forename: Elisa
authors.initials: E
authors.lastname: Llurba
authors.forename: Miquel
authors.initials: M
authors.lastname: Vilardell-Tarres
mesh_terms: D000026:Abortion, Habitual / Q000453:epidemiology* / Q000473:pathology*; D015415:Biomarkers; D055252:Cell-Derived Microparticles / Q000473:pathology*; D015897:Comorbidity; D005260:Female; D006801:Humans; D011247:Pregnancy; D011249:Pregnancy Complications, Cardiovascular / Q000453:epidemiology* / Q000473:pathology*; D011256:Pregnancy Outcome / Q000453:epidemiology*; D015995:Prevalence; D012307:Risk Factors; D013030:Spain / Q000453:epidemiology
chemical_list: D015415:Biomarkers