title: Association between the SPRY1 gene polymorphism and obesity-related traits and osteoporosis in Korean women.
abstract: BACKGROUND
  Emerging evidence has revealed a close relationship between obesity and osteoporosis. It was reported recently that conditional knockout of the Spry1 gene in mice adipocytes causes an increase in body fat and a decrease in bone mass, and that these phenotypes are rescued by Spry1 overexpression in adipose tissue. In this study, we investigated whether genetic variation in the human SPRY1 gene is associated with obesity-related phenotypes and/or osteoporosis in humans.
  
  
  METHODS
  We performed a candidate gene association analysis between the four single nucleotide polymorphisms (SNPs) and 14 imputed SNPs in the SPRY1 gene and obesity-related traits and osteoporosis in a Korean women cohort (3013 subjects).
  
  
  RESULTS
  All four SPRY1 gene SNPs were significantly associated with either obesity-related traits or osteoporosis. The TGCC haplotype in the SRPY1 gene showed simultaneous association with an increased risk for obesity-related traits, percentage body fat (p=0.0087) and percentage abdominal fat (p=0.047), and osteoporosis (odds ratio=1.50; p=0.025) in the recessive genetic model.
  
  
  CONCLUSIONS
  Our results support a previous finding in conditional Spry1 gene knockout mice and suggest that the SPRY1 gene is an important genetic factor for determining the risk of both obesity and osteoporosis in humans.
authors.affiliation: Department of Medical Genetics, Ajou University School of Medicine, Suwon, Republic of Korea.
authors.forename: Hyun-Seok
authors.initials: HS
authors.lastname: Jin
authors.forename: Bo-Young
authors.initials: BY
authors.lastname: Kim
authors.forename: Jeonghyun
authors.initials: J
authors.lastname: Kim
authors.forename: Kyung-Won
authors.initials: KW
authors.lastname: Hong
authors.forename: Suk-Yul
authors.initials: SY
authors.lastname: Jung
authors.forename: Yun-Seok
authors.initials: YS
authors.lastname: Lee
authors.forename: Dam
authors.initials: D
authors.lastname: Huh
authors.forename: Bermseok
authors.initials: B
authors.lastname: Oh
authors.forename: Yoon-Sok
authors.initials: YS
authors.lastname: Chung
authors.forename: Seon-Yong
authors.initials: SY
authors.lastname: Jeong
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D008297:Male; D008565:Membrane Proteins / Q000235:genetics*; D008875:Middle Aged; D009765:Obesity / Q000150:complications / Q000235:genetics*; D010024:Osteoporosis / Q000150:complications / Q000235:genetics* / Q000503:physiopathology; D010750:Phosphoproteins / Q000235:genetics*; D011110:Polymorphism, Genetic; D056910:Republic of Korea
chemical_list: D008565:Membrane Proteins; D010750:Phosphoproteins; C486055:SPRY1 protein, human