title: One-pot mechanosynthesis of aromatic amides and dipeptides from carboxylic acids and amines.
abstract: Environmentally friendly one-pot synthesis of amides, bis-amides and dipeptides by mechanochemical carbodiimide-mediated coupling of carboxylic acids and amines is described; high reaction yields and simple aqueous work-up allow for the clean, practical and fast preparation of a variety of compounds containing the amide bond from readily accessible reagents.
authors.affiliation: Division of Organic Chemistry and Biochemistry, Ruđer Bošković Institute, Bijenička cesta 54, HR-10002 Zagreb, Croatia. vstrukil@irb.hr
authors.forename: Vjekoslav
authors.initials: V
authors.lastname: Štrukil
authors.forename: Boris
authors.initials: B
authors.lastname: Bartolec
authors.forename: Tomislav
authors.initials: T
authors.lastname: Portada
authors.forename: Ivica
authors.initials: I
authors.lastname: Đilović
authors.forename: Ivan
authors.initials: I
authors.lastname: Halasz
authors.forename: Davor
authors.initials: D
authors.lastname: Margetić
mesh_terms: D000577:Amides / Q000138:chemical synthesis / Q000737:chemistry*; D000588:Amines / Q000737:chemistry*; D002234:Carbodiimides / Q000737:chemistry; D002264:Carboxylic Acids / Q000737:chemistry*; D004151:Dipeptides / Q000737:chemistry*; D014867:Water / Q000737:chemistry
chemical_list: D000577:Amides; D000588:Amines; D002234:Carbodiimides; D002264:Carboxylic Acids; D004151:Dipeptides; D014867:Water