title: Agraphia in patients with frontotemporal dementia and parkinsonism linked to chromosome 17 with P301L MAPT mutation: dysexecutive, aphasic, apraxic or spatial phenomenon?
abstract: OBJECTIVE
  Patients with frontotemporal dementia and parkinsonism linked to chromosome 17 (FTDP-17) may be agraphic. The study aimed at characterizing agraphia in individuals with a P301L MAPT mutation.
  
  
  METHODS
  Two pairs of siblings with FTDP-17 were longitudinally examined for agraphia in relation to language and cognitive deficits.
  
  
  RESULTS
  All patients presented with dysexecutive agraphia. In addition, in the first pair of siblings one sibling demonstrated spatial agraphia with less pronounced allographic agraphia and the other sibling had aphasic agraphia. Aphasic agraphia was also present in one sibling from the second pair.
  
  
  CONCLUSIONS
  Agraphia associated with FTDP-17 is very heterogeneous.
authors.affiliation: a Department of Neurology , St. Adalbert Hospital , Gdansk , Poland.
authors.forename: Emilia J
authors.initials: EJ
authors.lastname: Sitek
authors.forename: Ewa
authors.initials: E
authors.lastname: Narozanska
authors.forename: Anna
authors.initials: A
authors.lastname: Barczak
authors.forename: Barbara
authors.initials: B
authors.lastname: Jasinska-Myga
authors.forename: Michał
authors.initials: M
authors.lastname: Harciarek
authors.forename: Małgorzata
authors.initials: M
authors.lastname: Chodakowska-Zebrowska
authors.forename: Małgorzata
authors.initials: M
authors.lastname: Kubiak
authors.forename: Dariusz
authors.initials: D
authors.lastname: Wieczorek
authors.forename: Seweryna
authors.initials: S
authors.lastname: Konieczna
authors.forename: Rosa
authors.initials: R
authors.lastname: Rademakers
authors.forename: Matt
authors.initials: M
authors.lastname: Baker
authors.forename: Mariusz
authors.initials: M
authors.lastname: Berdynski
authors.forename: Bogna
authors.initials: B
authors.lastname: Brockhuis
authors.forename: Maria
authors.initials: M
authors.lastname: Barcikowska
authors.forename: Cezary
authors.initials: C
authors.lastname: Zekanowski
authors.forename: Kenneth M
authors.initials: KM
authors.lastname: Heilman
authors.forename: Zbigniew K
authors.initials: ZK
authors.lastname: Wszolek
authors.forename: Jarosław
authors.initials: J
authors.lastname: Slawek
mesh_terms: D000381:Agraphia / Q000175:diagnosis* / Q000235:genetics*; D001921:Brain / Q000473:pathology; D002886:Chromosomes, Human, Pair 17; D018450:Disease Progression; D005260:Female; D057180:Frontotemporal Dementia / Q000235:genetics* / Q000473:pathology / Q000523:psychology; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D009154:Mutation; D020734:Parkinsonian Disorders / Q000235:genetics* / Q000473:pathology / Q000523:psychology; D016875:tau Proteins / Q000235:genetics*
chemical_list: C054369:MAPT protein, human; D016875:tau Proteins