title: Alpha-synuclein elicits glucose uptake and utilization in adipocytes through the Gab1/PI3K/Akt transduction pathway.
abstract: Insulin is the main glucoregulator that promotes the uptake of glucose by tissues and the subsequent utilization of glucose as an energy source. In this paper, we describe a novel glucoregulator, the alpha-synuclein (SNCA) protein, that has previously been linked to Parkinson's disease. Treatment with recombinant SNCA promotes glucose uptake in vitro in preadipocytes and in vivo in the adipose tissues and skeletal muscles of mice through the LPAR2/Gab1/PI3K/Akt pathway; these effects occur independently of the insulin receptor. This function of SNCA represents a new mechanistic insight that creates novel avenues of research with respect to the process of glucose regulation.
authors.affiliation: Division of Gene Therapy Science, Graduate School of Medicine, Osaka University, 2-2 Yamada-oka, Suita, Osaka, 565-0871, Japan. gerardaraujo_@hotmail.com
authors.forename: Gerardo
authors.initials: G
authors.lastname: Rodriguez-Araujo
authors.forename: Hironori
authors.initials: H
authors.lastname: Nakagami
authors.forename: Hiroki
authors.initials: H
authors.lastname: Hayashi
authors.forename: Masaki
authors.initials: M
authors.lastname: Mori
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Shiuchi
authors.forename: Yasuhiko
authors.initials: Y
authors.lastname: Minokoshi
authors.forename: Yoshikazu
authors.initials: Y
authors.lastname: Nakaoka
authors.forename: Yoichi
authors.initials: Y
authors.lastname: Takami
authors.forename: Issei
authors.initials: I
authors.lastname: Komuro
authors.forename: Ryuichi
authors.initials: R
authors.lastname: Morishita
authors.forename: Yasufumi
authors.initials: Y
authors.lastname: Kaneda
mesh_terms: D048868:Adaptor Proteins, Signal Transducing; D017667:Adipocytes / Q000378:metabolism* / Q000502:physiology; D000704:Analysis of Variance; D000818:Animals; D002153:Calorimetry, Indirect; D002460:Cell Line; D005947:Glucose / Q000378:metabolism*; D006801:Humans; D015151:Immunoblotting; D047468:Immunoprecipitation; D051379:Mice; D019869:Phosphatidylinositol 3-Kinases / Q000378:metabolism; D010750:Phosphoproteins / Q000378:metabolism; D051057:Proto-Oncogene Proteins c-akt / Q000378:metabolism; D011994:Recombinant Proteins / Q000494:pharmacology*; D015398:Signal Transduction / Q000502:physiology*; D051844:alpha-Synuclein / Q000378:metabolism*
chemical_list: D048868:Adaptor Proteins, Signal Transducing; D005947:Glucose; D019869:Phosphatidylinositol 3-Kinases; D010750:Phosphoproteins; D051057:Proto-Oncogene Proteins c-akt; D011994:Recombinant Proteins; D051844:alpha-Synuclein; C490897:Gab1 protein, mouse