title: [The effect of the amino acid combinations on cell proliferation in tissue cultures in old rats].
abstract: In organotypic tissue culture, the effect of the 20 coded amino acids combinations, in the effective concentration of 0.05 ng/ml, on the cell proliferation development in the spleen, myocardium, pancreas and brain cortex explants in 24 months rats was investigated. The combinations of two amino acids (stimulating and inhibiting proliferation) produced in the tissue culture the stimulating effect, exceeding by 8-10% as compared to the isolating effect of the stimulating amino acid. The results obtained form the base for the further synthesis of new effective dipeptides to be used to increase the regeneration of tissues when aging.
authors.forename: N I
authors.initials: NI
authors.lastname: Chalisova
authors.forename: E A
authors.initials: EA
authors.lastname: Kontsevaia
authors.forename: A N
authors.initials: AN
authors.lastname: Zhekalov
authors.forename: D A
authors.initials: DA
authors.lastname: Siniachkin
mesh_terms: D000367:Age Factors; D000596:Amino Acids / Q000493:pharmacokinetics / Q000494:pharmacology; D000818:Animals; D017209:Apoptosis / Q000187:drug effects*; D001921:Brain; D002460:Cell Line; D049109:Cell Proliferation / Q000187:drug effects*; D008099:Liver; D009206:Myocardium; D010179:Pancreas; D051381:Rats; D017208:Rats, Wistar; D015398:Signal Transduction; D046509:Tissue Culture Techniques / Q000379:methods
chemical_list: D000596:Amino Acids