title: Hepatic sarcoidosis with an increased serum level of immunoglobulin G4.
abstract: A 70-year-old woman with an increased uptake of 18-Fluorodeoxyglucose (FDG) in whole liver on positron emission tomography (PET) was referred to our hospital. Laboratory examinations showed increased serum levels of total immunoglobulin G (IgG) and IgG4. Gallium scintigraphy showed a remarkable uptake in the liver but not in any other organs. On computed tomography (CT) and magnetic resonance imaging (MRI), multiple foci of abnormal density were observed in the liver, but the pancreas and bile duct lacked any indications of IgG4-related sclerosing disease. A liver biopsy specimen revealed multiple non-necrotizing granulomas. This is the first report of hepatic sarocidosis in a patient with an elevated serum level of IgG4.
authors.affiliation: Department of Medicine and Clinical Oncology, Graduate School of Medicine, Chiba University, Japan.
authors.forename: Masanori
authors.initials: M
authors.lastname: Inoue
authors.forename: Tetsuhiro
authors.initials: T
authors.lastname: Chiba
authors.forename: Yoh
authors.initials: Y
authors.lastname: Zen
authors.forename: Hajime
authors.initials: H
authors.lastname: Yokota
authors.forename: Tatsuo
authors.initials: T
authors.lastname: Kanda
authors.forename: Sadahisa
authors.initials: S
authors.lastname: Ogasawara
authors.forename: Harutoshi
authors.initials: H
authors.lastname: Sugiyama
authors.forename: Makoto
authors.initials: M
authors.lastname: Arai
authors.forename: Fumihiko
authors.initials: F
authors.lastname: Kanai
authors.forename: Makoto
authors.initials: M
authors.lastname: Ogawa
authors.forename: Fumio
authors.initials: F
authors.lastname: Imazeki
authors.forename: Osamu
authors.initials: O
authors.lastname: Yokosuka
mesh_terms: D000368:Aged; D005260:Female; D019788:Fluorodeoxyglucose F18; D005710:Gallium Radioisotopes; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood*; D008107:Liver Diseases / Q000175:diagnosis / Q000000981:diagnostic imaging / Q000276:immunology*; D049268:Positron-Emission Tomography; D019275:Radiopharmaceuticals; D012507:Sarcoidosis / Q000175:diagnosis / Q000000981:diagnostic imaging / Q000276:immunology*; D014057:Tomography, X-Ray Computed
chemical_list: D005710:Gallium Radioisotopes; D007074:Immunoglobulin G; D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18