title: Synthesis of aromatic nitriles using nonmetallic cyano-group sources.
abstract: Aromatic nitriles are prepared efficiently through transition-metal-mediated cyanation of aryl (pseudo)halides with metallic cyano-group sources, such as CuCN, KCN, NaCN, Zn(CN)(2), TMSCN, or K(4) [Fe(CN)(6)]. However, this approach often suffers from drawbacks, such as the formation of stoichiometric amounts of metal waste, the poisoning of the metal catalysts, or the generation of toxic HCN gas. As a result, a range of "nonmetallic" organic cyano-group sources have been explored for the cyanation of aryl halides and arene C-H bonds. This Minireview summarizes types of nonmetallic cyano-group sources and their applications in the preparation of aryl nitriles.
authors.affiliation: Department of Chemistry and Molecular-Level Interface Research Center, Korea Advanced Institute of Science & Technology, Daejeon 305-701, Korea.
authors.forename: Jinho
authors.initials: J
authors.lastname: Kim
authors.forename: Hyun Jin
authors.initials: HJ
authors.lastname: Kim
authors.forename: Sukbok
authors.initials: S
authors.lastname: Chang
mesh_terms: D003486:Cyanides / Q000737:chemistry*; D015394:Molecular Structure; D009570:Nitriles / Q000138:chemical synthesis* / Q000737:chemistry; D011108:Polymers / Q000737:chemistry
chemical_list: D003486:Cyanides; D009570:Nitriles; D011108:Polymers