title: Emerging viral diseases in kidney transplant recipients.
abstract: Viruses are the most important cause of infections and a major source of mortality in Kidney Transplant Recipients (KTRs). These patients may acquire viral infections through exogenous routes including community exposure, donor organs, and blood products or by endogenous reactivation of latent viruses. Beside major opportunistic infections due to CMV and EBV and viral hepatitis B and C, several viral diseases have recently emerged in KTRs. New medical practices or technologies, implementation of new diagnostic tools, and improved medical information have contributed to the emergence of these viral diseases in this special population. The purpose of this review is to summarize the current knowledge on emerging viral diseases and newly discovered viruses in KTRs over the last two decades. We identified viruses in the field of KT that had shown the greatest increase in numbers of citations in the NCBI PubMed database. BKV was the most cited in the literature and linked to an emerging disease that represents a great clinical concern in KTRs. HHV-8, PVB19, WNV, JCV, H1N1 influenza virus A, HEV, and GB virus were the main other emerging viruses. Excluding HHV8, newly discovered viruses have been infrequently linked to clinical diseases in KTRs. Nonetheless, pathogenicity can emerge long after the discovery of the causative agent, as has been the case for BKV. Overall, antiviral treatments are very limited, and reducing immunosuppressive therapy remains the cornerstone of management.
authors.affiliation: Centre de Néphrologie et Transplantation Rénale, APHM, CHU Conception, Marseille, France. vmoal@ap-hm.fr
authors.forename: Valérie
authors.initials: V
authors.lastname: Moal
authors.forename: Christine
authors.initials: C
authors.lastname: Zandotti
authors.forename: Philippe
authors.initials: P
authors.lastname: Colson
mesh_terms: D006801:Humans; D016030:Kidney Transplantation / Q000009:adverse effects*; D009894:Opportunistic Infections / Q000209:etiology / Q000821:virology*; D014777:Virus Diseases / Q000209:etiology / Q000821:virology*; D014780:Viruses / Q000145:classification / Q000235:genetics / Q000302:isolation & purification