title: Copper-catalyzed enantioselective synthesis of axially chiral allenes.
abstract: A simple copper-catalyzed enantioselective synthesis of axially chiral chloroallenes from the propargylic dichlorides is reported, employing a catalytic amount of easily prepared SimplePhos ligand. Exclusive formation of the desired allenes was observed with good enantioselectivities (ee's 62-96%). Further transformations to trisubstituted allenes or terminal alkynes with a propargylic quaternary carbon center keep a high level of enantiopurity.
authors.affiliation: Department of Organic Chemistry, University of Geneva 30, quai Ernest Ansermet CH-1211 Geneva 4, Switzerland.
authors.forename: Hailing
authors.initials: H
authors.lastname: Li
authors.forename: Daniel
authors.initials: D
authors.lastname: Müller
authors.forename: Laure
authors.initials: L
authors.lastname: Guénée
authors.forename: Alexandre
authors.initials: A
authors.lastname: Alexakis