title: Gankyrin plays an essential role in estrogen-driven and GPR30-mediated endometrial carcinoma cell proliferation via the PTEN/PI3K/AKT signaling pathway.
abstract: Gankyrin has been implicated in the formation of multiple cancer types, although its roles in estrogen-driven endometrial carcinoma remain unclarified. We evaluated the expression of Gankyrin in endometrial tissues and further explored its roles in estrogen-driven and GPR30-mediated endometrial cancer cell proliferation. Gankyrin was overexpressed in endometrial carcinoma tissues and showed an inverse relationship with the pattern of PTEN expression. The depletion or overexpression of Gankyrin induced endometrial cancer cell proliferation inhibition or expansion, respectively, which was associated with estrogen-driven GPR30 signaling via the PTEN/PI3K/AKT pathway. This study suggests that Gankyrin is functional in endometrial cancer development.
authors.affiliation: Department of Obstetrics and Gynecology, Shanghai First People's Hospital, Shanghai Jiaotong University, Shanghai 200080, China.
authors.forename: Jiawen
authors.initials: J
authors.lastname: Zhang
authors.forename: Yongbin
authors.initials: Y
authors.lastname: Yang
authors.forename: Zhenbo
authors.initials: Z
authors.lastname: Zhang
authors.forename: Yinyan
authors.initials: Y
authors.lastname: He
authors.forename: Zhiqiang
authors.initials: Z
authors.lastname: Liu
authors.forename: Yinhua
authors.initials: Y
authors.lastname: Yu
authors.forename: Sufang
authors.initials: S
authors.lastname: Wu
authors.forename: Bin
authors.initials: B
authors.lastname: Cai
authors.forename: Youji
authors.initials: Y
authors.lastname: Feng
mesh_terms: D000328:Adult; D000368:Aged; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D016889:Endometrial Neoplasms / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D004967:Estrogens / Q000378:metabolism* / Q000494:pharmacology; D005260:Female; D015972:Gene Expression Regulation, Neoplastic / Q000187:drug effects; D006801:Humans; D008875:Middle Aged; D009367:Neoplasm Staging; D051059:PTEN Phosphohydrolase / Q000235:genetics / Q000378:metabolism*; D019869:Phosphatidylinositol 3-Kinases / Q000378:metabolism*; D046988:Proteasome Endopeptidase Complex / Q000235:genetics / Q000378:metabolism*; D011518:Proto-Oncogene Proteins / Q000235:genetics / Q000378:metabolism*; D051057:Proto-Oncogene Proteins c-akt / Q000378:metabolism*; D011960:Receptors, Estrogen / Q000378:metabolism*; D043562:Receptors, G-Protein-Coupled / Q000378:metabolism*; D015398:Signal Transduction / Q000187:drug effects
chemical_list: D004967:Estrogens; C109584:GPER1 protein, human; C403591:PSMD10 protein, human; D011518:Proto-Oncogene Proteins; D011960:Receptors, Estrogen; D043562:Receptors, G-Protein-Coupled; D019869:Phosphatidylinositol 3-Kinases; D051057:Proto-Oncogene Proteins c-akt; D051059:PTEN Phosphohydrolase; C494929:PTEN protein, human; D046988:Proteasome Endopeptidase Complex
keywords: Endometrial carcinoma; Estrogen; Gankyrin; PTEN; Proliferation