title: [Clinical application of the 3-dimensional speckle tracking imaging in coronary artery disease].
abstract: OBJECTIVE
  To observe the 3-dimensional speckle tracking imaging (3D-STI) in clinical diagnosis of coronary artery disease by quantitatively evaluating left ventricular segmental and global systolic function.
  
  
  METHODS
  According to the selective coronary artery angiography, 150 inpatients suspected of coronary artery disease were divided into 5 groups according to the distribution of the affected coronary arteries: a left anterior descending coronary artery group (LAD, n=46), a left circumflex coronary artery group (LCX, n=25), a right coronary artery group (RCA, n=23), a multivessel group (n=26), and a normal group (n=30). Gensini score was calculated according to coronary artery angiography. Conventional echocardiography was applied in each patient and wall motion score index (WMSI) was calculated. 3D-STI was applied in each patient to evaluate the segmental and global systolic function in the left ventricle.
  
  
  RESULTS
  Compared with the normal group, ejection fraction was decreased in the multi-vessel group alone (P<0.05). Peak systolic 3D strains in all segments were decreased in the multi-vessel group (P<0.01), while peak systolic 3D strains in the main blood-supply segments were decreased significantly in the rest of the groups (P<0.05). Global 3-dimensional strain (G3DS) was negatively correlated with Gensini score in patients with coronary artery disease (r= -0.76, P<0.01). Receiver operating characteristic curve analysis demonstrated that G3DS was more sensitive and accurate in clinical diagnosis of coronary artery disease.
  
  
  CONCLUSIONS
  3D-STI can quantitatively evaluate the segmental and global systolic function of the left ventricle, and reflect the extent of coronary artery stenosis in patients with coronary artery disease.
authors.affiliation: Department of Ultrasound, Central South University, Changsha, China.
authors.forename: Wenhui
authors.initials: W
authors.lastname: Zhu
authors.forename: Qin
authors.initials: Q
authors.lastname: Meng
authors.forename: Jidong
authors.initials: J
authors.lastname: Xiao
authors.forename: Yan
authors.initials: Y
authors.lastname: Wang
authors.forename: Yongfeng
authors.initials: Y
authors.lastname: Zhao
mesh_terms: D017023:Coronary Angiography; D003324:Coronary Artery Disease / Q000175:diagnosis*; D023921:Coronary Stenosis; D004452:Echocardiography; D006352:Heart Ventricles; D006801:Humans; D021621:Imaging, Three-Dimensional; D012372:ROC Curve; D013599:Systole