title: Diabetic cardiomyopathy and metabolic remodeling of the heart.
abstract: The incidence and prevalence of diabetes mellitus are both increasing rapidly in societies around the globe. The majority of patients with diabetes succumb ultimately to heart disease, much of which stems from atherosclerotic disease and hypertension. However, the diabetic milieu is itself intrinsically noxious to the heart, and cardiomyopathy can develop independent of elevated blood pressure or coronary artery disease. This process, termed diabetic cardiomyopathy, is characterized by significant changes in the physiology, structure, and mechanical function of the heart. Presently, therapy for patients with diabetes focuses largely on glucose control, and attention to the heart commences with the onset of symptoms. When the latter develops, standard therapy for heart failure is applied. However, recent studies highlight that specific elements of the pathogenesis of diabetic heart disease are unique, raising the prospect of diabetes-specific therapeutic intervention. Here, we review recently unveiled insights into the pathogenesis of diabetic cardiomyopathy and associated metabolic remodeling with an eye toward identifying novel targets with therapeutic potential.
authors.affiliation: Department of Internal Medicine (Cardiology), University of Texas Southwestern Medical Center, Dallas, TX 75235, USA.
authors.forename: Pavan K
authors.initials: PK
authors.lastname: Battiprolu
authors.forename: Camila
authors.initials: C
authors.lastname: Lopez-Crisosto
authors.forename: Zhao V
authors.initials: ZV
authors.lastname: Wang
authors.forename: Andriy
authors.initials: A
authors.lastname: Nemchenko
authors.forename: Sergio
authors.initials: S
authors.lastname: Lavandero
authors.forename: Joseph A
authors.initials: JA
authors.lastname: Hill
mesh_terms: D058065:Diabetic Cardiomyopathies / Q000188:drug therapy / Q000473:pathology*; D016503:Drug Delivery Systems; D006801:Humans; D020257:Ventricular Remodeling