title: 2-Amino-4-arylthiazole compounds as TRPA1 antagonists (WO 2012085662): a patent evaluation.
abstract: The patent claims 2-amino-4-arylthiazole derivative compounds as inhibitors of the TRPA1 (transient receptor potential ankyrin, member 1) receptor. These compounds are potent antagonists on the basis of the results of in vitro assays, and are expected to be useful for treating conditions and disorders associated with TRPA1 function such as pain, chronic pain, neuropathic pain, rheumatoid arthritic pain, osteoarthritic pain, diabetic neuropathy and inflammatory disorders.
authors.affiliation: Endocannabinoid Research Group Istituto di Cibernetica CNR, Pozzuoli, Italy. l.depetrocellis@cib.na.cnr.it
authors.forename: Luciano
authors.initials: L
authors.lastname: De Petrocellis
authors.forename: Aniello
authors.initials: A
authors.lastname: Schiano Moriello
mesh_terms: D000818:Animals; D015220:Calcium Channels / Q000378:metabolism; D015195:Drug Design; D006801:Humans; D007249:Inflammation / Q000188:drug therapy / Q000473:pathology; D009419:Nerve Tissue Proteins / Q000037:antagonists & inhibitors* / Q000378:metabolism; D010146:Pain / Q000188:drug therapy / Q000209:etiology / Q000473:pathology; D010330:Patents as Topic; D000074025:TRPA1 Cation Channel; D013844:Thiazoles / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D050051:Transient Receptor Potential Channels / Q000037:antagonists & inhibitors* / Q000378:metabolism
chemical_list: D015220:Calcium Channels; D009419:Nerve Tissue Proteins; D000074025:TRPA1 Cation Channel; C473350:TRPA1 protein, human; D013844:Thiazoles; D050051:Transient Receptor Potential Channels