title: Differential involvement of the left frontal and temporal regions in verb naming: a tDCS treatment study.
abstract: OBJECTIVE
  In aphasic patients, some studies have already emphasized the efficacy of transcranial direct current stimulation (tDCS) during the treatment of noun retrieval deficits. To date, in the same population, there are have been no studies addressing tDCS effects in the recovery of verb retrieval deficits. In this study, we wanted to test the potential of tDCS to improve verb production in a group of aphasic patients.
  
  
  METHODS
  Seven chronic subjects participated in an intensive language training for their difficulties in action naming. Each subject was treated with tDCS (20 min., 1 mA) over the left hemisphere in three different conditions: anodic tDCS over Wernicke's area, anodic tDCS and sham stimulation over Broca's area. Each experimental condition was performed in five consecutive daily sessions over three weeks with 6 days of intersession interval.
  
  
  RESULTS
  In all patients, results showed a significantly better response accuracy during the anodic tDCS over Broca's area with respect to the other two conditions which still persisted at one month after the end of the treatment suggesting a long-term effect on the recovery of their verb retrieval deficits.
  
  
  CONCLUSIONS
  These findings further confirm that tDCS represents a useful new therapeutic interventions for the rehabilitation of lexical deficits in aphasic patients.
authors.affiliation: Facoltà di Medicina, Università Politecnica Marche, Ancona, Italy IRCCS Fondazione Santa Lucia, Roma, Italy. p.marangolo@univpm.it
authors.forename: Paola
authors.initials: P
authors.lastname: Marangolo
authors.forename: Valentina
authors.initials: V
authors.lastname: Fiori
authors.forename: Margherita
authors.initials: M
authors.lastname: Di Paola
authors.forename: Susanna
authors.initials: S
authors.lastname: Cipollari
authors.forename: Carmelina
authors.initials: C
authors.lastname: Razzano
authors.forename: Massimiliano
authors.initials: M
authors.lastname: Oliveri
authors.forename: Carlo
authors.initials: C
authors.lastname: Caltagirone
mesh_terms: D000368:Aged; D001037:Aphasia / Q000473:pathology / Q000523:psychology* / Q000628:therapy*; D032882:Comprehension; D003627:Data Interpretation, Statistical; D004599:Electric Stimulation Therapy; D004566:Electrodes; D005260:Female; D005500:Follow-Up Studies; D005625:Frontal Lobe / Q000473:pathology / Q000502:physiology*; D006801:Humans; D007802:Language; D008279:Magnetic Resonance Imaging; D008297:Male; D011939:Mental Recall / Q000187:drug effects*; D008875:Middle Aged; D013067:Speech Perception; D020521:Stroke / Q000150:complications / Q000473:pathology / Q000523:psychology; D013702:Temporal Lobe / Q000473:pathology / Q000502:physiology*