title: Repeated simultaneous cortical electrophysiological and behavioral recording in rats exposed to manganese-containing nanoparticles.
abstract: Male Wistar rats wearing chronically implanted cortical electrodes were exposed to Mn-containing nanoparticles via the airways for 8 weeks following a 2-week pre-exposure period. The rats' cortical electrical activity and open field motility was recorded simultaneously, in weekly repetitions. It was supposed that this technique can provide better insight in the development of Mn-induced CNS damage. Decreased motility (less distance covered, longer periods of immobility) and increased total power of cortical electrical activity developed in parallel in the first 4-5 weeks of treatment but showed little change afterwards. Both the behavioral and the electrophysiological effect were in fair correlation with the rats' internal Mn exposure determined from brain samples. The results confirmed the non-linear dose- and time-dependence of Mn effects suggested by previous studies. Repeated simultaneous behavioral and electrophysiological recording during a longer treatment with neurotoxic metals (or other xenobiotics) seems to be a promising method.
authors.affiliation: Department of Public Health, University of Szeged, Faculty of Medicine, Szeged, Hungary.
authors.forename: S Z
authors.initials: SZ
authors.lastname: Takács
authors.forename: Andrea
authors.initials: A
authors.lastname: Szabó
authors.forename: G
authors.initials: G
authors.lastname: Oszlánczi
authors.forename: P
authors.initials: P
authors.lastname: Pusztai
authors.forename: A
authors.initials: A
authors.lastname: Sápi
authors.forename: Z
authors.initials: Z
authors.lastname: Kónya
authors.forename: A
authors.initials: A
authors.lastname: Papp
mesh_terms: D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects*; D001822:Body Burden; D058256:Brain Waves / Q000187:drug effects; D002540:Cerebral Cortex / Q000187:drug effects* / Q000503:physiopathology; D004305:Dose-Response Relationship, Drug; D004569:Electroencephalography; D019570:Inhalation Exposure; D008297:Male; D017895:Manganese Compounds; D020149:Manganese Poisoning / Q000175:diagnosis / Q000209:etiology* / Q000503:physiopathology / Q000523:psychology; D053768:Metal Nanoparticles; D009043:Motor Activity / Q000187:drug effects*; D010087:Oxides / Q000633:toxicity*; D051381:Rats; D017208:Rats, Wistar; D013997:Time Factors
chemical_list: D017895:Manganese Compounds; D010087:Oxides; C016552:manganese dioxide