title: Challenges after the first decade of transcatheter aortic valve replacement: focus on vascular complications, stroke, and paravalvular leak.
abstract: Transcatheter aortic valve replacement (TAVR) is entering its second decade. Three major clinical challenges have emerged from the first decade of experience: vascular complications, stroke, and paravalvular leak (PVL). Major vascular complications remain common and independently predict major bleeding, transfusion, renal failure, and mortality. Although women are more prone to vascular complications, overall they have better survival than men. Further predictors of major vascular complications include heavily diseased femoral arteries and operator experience. Strategies to minimize vascular complications include a multimodal approach and sleeker delivery systems. Although cerebral embolism is very common during TAVR, it mostly is asymptomatic. Major stroke independently predicts prolonged recovery and increased mortality. Identified stroke predictors include functional disability, previous stroke, a transapical approach, and atrial fibrillation. Embolic protection devices are in development to mitigate the risk of embolic stroke after TAVR. PVL is common and significantly decreases survival. Undersizing of the valve prosthesis can be minimized with 3-dimensional imaging by computed tomography or echocardiography to describe the elliptic aortic annulus accurately. The formal grading of PVL severity in TAVR is based on its percentage of the circumferential extent of the aortic valve annulus. Further emerging management strategies for PVL include a repositionable valve prosthesis and transcatheter plugging. The first decade of TAVR has ushered in a new paradigm for the multidisciplinary management of valvular heart disease. The second decade likely will build on this wave of initial success with further significant innovations.
authors.affiliation: Cardiothoracic and Vascular Section, Department of Anesthesiology, School of Medicine and Public Health, University of Wisconsin, Madison, WI, USA.
authors.forename: Christopher
authors.initials: C
authors.lastname: Reidy
authors.forename: Aris
authors.initials: A
authors.lastname: Sophocles
authors.forename: Harish
authors.initials: H
authors.lastname: Ramakrishna
authors.forename: Kamrouz
authors.initials: K
authors.lastname: Ghadimi
authors.forename: Prakash A
authors.initials: PA
authors.lastname: Patel
authors.forename: John G T
authors.initials: JG
authors.lastname: Augoustides
mesh_terms: D006328:Cardiac Catheterization / Q000009:adverse effects* / Q000639:trends; D019918:Heart Valve Prosthesis Implantation / Q000009:adverse effects* / Q000639:trends; D006801:Humans; D011183:Postoperative Complications / Q000453:epidemiology* / Q000517:prevention & control; D020521:Stroke / Q000453:epidemiology* / Q000517:prevention & control; D016896:Treatment Outcome; D014652:Vascular Diseases / Q000453:epidemiology / Q000517:prevention & control