title: [Effect of pamidronate on cementoclast and osteoclast differentiation factor expression during orthodontic tooth movement in rats].
abstract: OBJECTIVE
  To investigate the influence of pamidronate on cementoclast and osteoclast differentiation factor(ODF) expression during orthodontic tooth movement in rats.
  
  
  METHODS
  24 female, 6-week-old SPF Wistar rats were selected and the animal models for orthodontic tooth movement were established. Each rat's maxillary was divided into experimental side and control side. Pamidronate(50 μL) was injected into the sub-periosteum area adjacent to the left upper first molar(experimental side) every 3 days during the experiment, while 0.9%NS(50 μL) was injected into the corresponding area of the control side. The rats were executed in batch on the 3rd, 7th and 14th day respectively during the orthodontic treatment for detecting the amount of cementoclast and the expression of ODF in the periodontal tissues. All statistical analysis was performed using PASW Statistics 18 software package.
  
  
  RESULTS
  The amount of cementoclasts was significantly less in the experimental side than that in the control side on the 7th and 14th days(P<0.05). The expression of ODF was significantly less in the experimental side than that in the control side on the 7th and 14th days(P<0.05).
  
  
  CONCLUSIONS
  Local injection of pamidronate can reduce the number of cementoclast and the expression of ODF.
authors.affiliation: School of Stomatology, Shandong University, Jinan, Shandong Province, China.
authors.forename: Jing
authors.initials: J
authors.lastname: Zeng
authors.forename: Xu-xia
authors.initials: XX
authors.lastname: Wang
authors.forename: Yu-long
authors.initials: YL
authors.lastname: Jia
authors.forename: Dan
authors.initials: D
authors.lastname: Ma
authors.forename: Sheng-lin
authors.initials: SL
authors.lastname: Wang
authors.forename: Jun
authors.initials: J
authors.lastname: Zhang
mesh_terms: D000818:Animals; D004164:Diphosphonates; D005260:Female; D008437:Maxilla; D008963:Molar; D010010:Osteoclasts; D000077268:Pamidronate; D010519:Periodontium; D053245:RANK Ligand; D051381:Rats; D017208:Rats, Wistar; D014087:Tooth Movement Techniques
chemical_list: D004164:Diphosphonates; D053245:RANK Ligand; D000077268:Pamidronate