title: A new method for a quantitative determination of piroxicam in pharmaceutical formulations using FT-IR spectrometry.
abstract: A Fourier transform infrared (FT-IR) spectrometric method was developed for the rapid, and direct measurement of piroxicam (Pir) in pharmaceutical drugs. Pir is a well known and very effective antiinflammatory drug. Pir can be determined by various methods and now we are adding a new one that uses a Fourier transform infrared spectrophotometric technique. Conventional spectra were compared for best determination of active substance in pharmaceutical formulations. The Beer-Lambert law and two chemometric approaches, partial least squares (PLS) and principal component regression (PCR+) methods, were tried in data processing.
authors.affiliation: SCIENT - Research Center for Instrumental Analysis, (S.C. CROMATEC_PLUS S.R.L.), 18 Sos. Cotroceni, Bucharest - 6, 060114, Romania.
authors.forename: Andrei A
authors.initials: AA
authors.lastname: Bunaciu
authors.forename: Şerban
authors.initials: Ş
authors.lastname: Fleschin
authors.forename: Hassan Y
authors.initials: HY
authors.lastname: Aboul-Enein
mesh_terms: D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000032:analysis* / Q000737:chemistry; D002138:Calibration; D009824:Ointments / Q000737:chemistry; D010894:Piroxicam / Q000032:analysis* / Q000737:chemistry; D017550:Spectroscopy, Fourier Transform Infrared / Q000379:methods; D013607:Tablets / Q000737:chemistry
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D009824:Ointments; D013607:Tablets; D010894:Piroxicam