title: Inflammation-based prognostic score is a useful predictor of postoperative outcome in patients with extrahepatic cholangiocarcinoma.
abstract: OBJECTIVE
  Recent studies have revealed that the Glasgow prognostic score (GPS), an inflammation-based prognostic score, is useful for predicting outcome in a variety of cancers. This study sought to investigate the significance of GPS for prognostication of patients who underwent surgery with extrahepatic cholangiocarcinoma.
  
  
  METHODS
  We retrospectively analyzed a total of 62 patients who underwent resection for extrahepatic cholangiocarcinoma. We calculated the GPS as follows: patients with both an elevated C-reactive protein (>10 mg/L) and hypoalbuminemia (<35 g/L) were allocated a score of 2; patients with one or none of these abnormalities were allocated a s ore of 1 or 0, respectively. Prognostic significance was analyzed by the log-rank test and a Cox proportional hazards model.
  
  
  RESULTS
  Overall survival rate was 25.5 % at 5 years for all 62 patients. Venous invasion (p = 0.01), pathological primary tumor category (p = 0.013), lymph node metastasis category (p < 0.001), TNM stage (p < 0.001), and GPS (p = 0.008) were significantly associated with survival by univariate analysis. A Cox model demonstrated that increased GPS was an independent predictive factor with poor prognosis.
  
  
  CONCLUSIONS
  The preoperative GPS is a useful predictor of postoperative outcome in patients with extrahepatic cholangiocarcinoma.
authors.affiliation: Department of Organ Transplantation Gastroenterological and Hepatobiliary Surgery, Graduate School of Comprehensive Human Sciences, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, 305-8575, Japan.
authors.forename: Yukio
authors.initials: Y
authors.lastname: Oshiro
authors.forename: Ryoko
authors.initials: R
authors.lastname: Sasaki
authors.forename: Kiyoshi
authors.initials: K
authors.lastname: Fukunaga
authors.forename: Tadashi
authors.initials: T
authors.lastname: Kondo
authors.forename: Tatsuya
authors.initials: T
authors.lastname: Oda
authors.forename: Hideto
authors.initials: H
authors.lastname: Takahashi
authors.forename: Nobuhiro
authors.initials: N
authors.lastname: Ohkohchi
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001650:Bile Duct Neoplasms / Q000473:pathology / Q000601:surgery*; D017734:Bile Ducts, Extrahepatic; D014408:Biomarkers, Tumor / Q000378:metabolism; D002097:C-Reactive Protein / Q000378:metabolism; D018281:Cholangiocarcinoma / Q000473:pathology / Q000601:surgery*; D004322:Drainage / Q000379:methods; D005260:Female; D006801:Humans; D034141:Hypoalbuminemia / Q000378:metabolism; D007249:Inflammation / Q000473:pathology; D008197:Lymph Node Excision; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D011379:Prognosis; D016016:Proportional Hazards Models; D012189:Retrospective Studies; D015996:Survival Rate
chemical_list: D014408:Biomarkers, Tumor; D002097:C-Reactive Protein