title: The role of A20 in the pathogenesis of lymphocytic malignancy.
abstract: Autoimmune phenomena were identified in many different cases of hematological diseases and solid tumors, which may be due to alterations in the expression and function of the NF-κB signaling pathway. Recently, a number of studies have shown that the deletion or mutation of A20, a negative regulator of NF-κB, is frequently found in lymphomas, suggesting that it may be a linker between the altered immune response and leukemogenesis. The aim of this review is to summarize current findings of the A20 biological functions and its molecular mechanism as a tumor suppressor and immune regulator. The identification of A20 mutations and deletions in lymphocytic malignancy and the predictive significance of these aberrations are also reviewed.
authors.affiliation: Institute of Hematology, Medical College, Jinan University, Guangzhou 510632, China. yangqiuli@hotmail.com.
authors.forename: Fan
authors.initials: F
authors.lastname: Zhang
authors.forename: Lijiang
authors.initials: L
authors.lastname: Yang
authors.forename: Yangqiu
authors.initials: Y
authors.lastname: Li