title: [Production of timolol containing calcium-phosphate nanoparticles and evaluation of their effect on intraocular pressure in experiment].
abstract: Methodology for production of calcium-phosphate nanoparticles is developed and its efficacy as a drug carrier system is estimated by example of timolol. Conditions for production of particles with optimal size and resistance are determined, methodology of loading of particles with timolol is developed. Physical parameters of particles (form, size, relief), kinetics of saturation with drug and its release are studied. Packaging of timolol into calcium phosphate nanoparticles was showed to enhance and prolong its hypotensive effect in experiment on healthy rabbits.
authors.forename: E V
authors.initials: EV
authors.lastname: Shimanovskaia
authors.forename: O V
authors.initials: OV
authors.lastname: Beznos
authors.forename: N L
authors.initials: NL
authors.lastname: Kliachko
authors.forename: O A
authors.initials: OA
authors.lastname: Kost
authors.forename: I I
authors.initials: II
authors.lastname: Nikol'skaia
authors.forename: T A
authors.initials: TA
authors.lastname: Pavlenko
authors.forename: N B
authors.initials: NB
authors.lastname: Chesnokova
authors.forename: A V
authors.initials: AV
authors.lastname: Kabanov
mesh_terms: D060433:Administration, Ophthalmic; D000818:Animals; D002130:Calcium Phosphates; D004337:Drug Carriers / Q000008:administration & dosage / Q000493:pharmacokinetics; D016503:Drug Delivery Systems / Q000379:methods*; D007429:Intraocular Pressure / Q000187:drug effects*; D053758:Nanoparticles / Q000737:chemistry*; D036103:Nanotechnology; D011817:Rabbits; D013678:Technology, Pharmaceutical / Q000379:methods; D013999:Timolol / Q000008:administration & dosage* / Q000493:pharmacokinetics; D016896:Treatment Outcome
chemical_list: D002130:Calcium Phosphates; D004337:Drug Carriers; D013999:Timolol