title: Clicked europium dipicolinate complexes for protein X-ray structure determination.
abstract: New trisdipicolinic acid-lanthanide complexes are reported as phasing agents for X-ray crystallography of proteins. It is demonstrated that CuAAC modifications allow protein co-crystallization with low concentration of lanthanide complexes leading to an accurate structure determination.
authors.affiliation: CEA, DSV, Institut de Biologie Structurale (IBS), 41 rue Jules Horowitz, Grenoble F-38027, France.
authors.forename: Romain
authors.initials: R
authors.lastname: Talon
authors.forename: Lionel
authors.initials: L
authors.lastname: Nauton
authors.forename: Jean-Louis
authors.initials: JL
authors.lastname: Canet
authors.forename: Richard
authors.initials: R
authors.lastname: Kahn
authors.forename: Eric
authors.initials: E
authors.lastname: Girard
authors.forename: Arnaud
authors.initials: A
authors.lastname: Gautier
mesh_terms: D018360:Crystallography, X-Ray; D005063:Europium / Q000737:chemistry*; D008958:Models, Molecular; D015394:Molecular Structure; D009113:Muramidase / Q000737:chemistry* / Q000378:metabolism; D009942:Organometallic Compounds / Q000138:chemical synthesis / Q000737:chemistry*; D010848:Picolinic Acids / Q000737:chemistry*; D010940:Plant Proteins / Q000737:chemistry*
chemical_list: D009942:Organometallic Compounds; D010848:Picolinic Acids; D010940:Plant Proteins; D005063:Europium; C003427:thaumatin protein, plant; C421864:hen egg lysozyme; D009113:Muramidase