title: HBVdb: a knowledge database for Hepatitis B Virus.
abstract: We have developed a specialized database, HBVdb (http://hbvdb.ibcp.fr), allowing the researchers to investigate the genetic variability of Hepatitis B Virus (HBV) and viral resistance to treatment. HBV is a major health problem worldwide with more than 350 million individuals being chronically infected. HBV is an enveloped DNA virus that replicates by reverse transcription of an RNA intermediate. HBV genome is optimized, being circular and encoding four overlapping reading frames. Indeed, each nucleotide of the genome takes part in the coding of at least one protein. However, HBV shows some genome variability leading to at least eight different genotypes and recombinant forms. The main drugs used to treat infected patients are nucleos(t)ides analogs (reverse transcriptase inhibitors). Unfortunately, HBV mutants resistant to these drugs may be selected and be responsible for treatment failure. HBVdb contains a collection of computer-annotated sequences based on manually annotated reference genomes. The database can be accessed through a web interface that allows static and dynamic queries and offers integrated generic sequence analysis tools and specialized analysis tools (e.g. annotation, genotyping, drug resistance profiling).
authors.affiliation: Unité Bases Moléculaires et Structurales des Systèmes Infectieux, Lyon, France.
authors.forename: Juliette
authors.initials: J
authors.lastname: Hayer
authors.forename: Fanny
authors.initials: F
authors.lastname: Jadeau
authors.forename: Gilbert
authors.initials: G
authors.lastname: Deléage
authors.forename: Alan
authors.initials: A
authors.lastname: Kay
authors.forename: Fabien
authors.initials: F
authors.lastname: Zoulim
authors.forename: Christophe
authors.initials: C
authors.lastname: Combet
mesh_terms: D030541:Databases, Genetic; D024882:Drug Resistance, Viral / Q000235:genetics; D014644:Genetic Variation; D016679:Genome, Viral; D060005:Genotyping Techniques; D006515:Hepatitis B virus / Q000187:drug effects / Q000235:genetics*; D020407:Internet; D058977:Molecular Sequence Annotation; D014584:User-Computer Interface; D014764:Viral Proteins / Q000235:genetics
chemical_list: D014764:Viral Proteins