title: [The role of oxidative stress in skin aging].
abstract: The review covers the literature proving that ROS formation in aging overbalances the antioxidant defense system potential of the skin structure (horny layer, epidermis and dermis). It has been shown that ROS are involved in the pathogenesis of inflammatory processes and allergic responses in the skin. The role of ROS and antioxidant systems in the cell-mediated responses associated with the MAP kinase activity in the skin is discussed. Special attention is paid to the ultraviolet irradiation exposure, which accounts for its genotoxic, immunosuppressive and carcinogenic effects on the skin.
authors.forename: L S
authors.initials: LS
authors.lastname: Kozina
authors.forename: I V
authors.initials: IV
authors.lastname: Borzova
authors.forename: V A
authors.initials: VA
authors.lastname: Arutiunov
authors.forename: G A
authors.initials: GA
authors.lastname: Ryzhak
mesh_terms: D000368:Aged; D000975:Antioxidants / Q000378:metabolism*; D006801:Humans; D007111:Immunity, Cellular; D007249:Inflammation / Q000378:metabolism / Q000503:physiopathology; D008660:Metabolism; D020928:Mitogen-Activated Protein Kinases / Q000378:metabolism*; D018384:Oxidative Stress; D017382:Reactive Oxygen Species / Q000378:metabolism*; D012867:Skin / Q000378:metabolism / Q000473:pathology / Q000503:physiopathology / Q000528:radiation effects; D015595:Skin Aging; D012878:Skin Neoplasms / Q000209:etiology / Q000378:metabolism / Q000473:pathology; D014466:Ultraviolet Rays / Q000009:adverse effects
chemical_list: D000975:Antioxidants; D017382:Reactive Oxygen Species; D020928:Mitogen-Activated Protein Kinases