title: Interleukin-6 polymorphisms are associated with obesity and hyperglycemia in Mexican adolescents.
abstract: OBJECTIVE
  Interleukin-6 is an inflammatory response mediator used as a metabolic marker of obesity. Polymorphisms IL6 -597C>A, -572G>C, and -174G>C modify the production of this protein. The associations between these haplotypes and obesity or metabolic markers have not been studied in adolescents, so an analysis of these associations was performed.
  
  
  METHODS
  The cross-sectional study included 745 apparently healthy 14- to 19-year-old adolescents. Obesity, serum glucose, insulin, triglycerides, total cholesterol, low-density lipoprotein-cholesterol, high-density lipoprotein-cholesterol (HDL-C), and high-sensitivity C-reactive protein (hs-CRP) were evaluated, and IL6 -597G>A, -572G>C and -174G>C polymorphisms determined. The associations were analyzed using multivariate logistic regression models.
  
  
  RESULTS
  The allele frequencies were 0.15 for -597A and -174C and 0.30 for -572C. Genotypes were in Hardy-Weinberg equilibrium. IL-6(-597/-572/-174) haplotypes GGG, GCG, and AGC comprised 99.74% of the total haplotypes. The associations were significant between genotype GCG/GCG and hyperglycemia (OR = 2.86, 95% CI = 1.02-7.97); between GCG/GCG and high hs-CRP (OR = 6.17, 95% CI = 1.13-33.77); between AGC/AGC and obesity (OR = 4.42, 95% CI = 1.40-14.01); and between GGG/GCG and low HDL-C (OR = 1.53, 95% CI = 1.03-2.28).
  
  
  CONCLUSIONS
  Genotypes of the IL6(-597/-572/-174) polymorphisms are associated with metabolic risk factors in Mexican adolescents.
authors.affiliation: Unidad de Investigación Epidemiológica y en Servicios de Salud del Adolescente, IMSS, Tonalá, Jalisco, Mexico.
authors.forename: Guadalupe
authors.initials: G
authors.lastname: Ramírez-López
authors.forename: Eliseo
authors.initials: E
authors.lastname: Portilla-de Buen
authors.forename: José
authors.initials: J
authors.lastname: Sánchez-Corona
authors.forename: Jorge
authors.initials: J
authors.lastname: Salmerón-Castro
authors.forename: Francisco
authors.initials: F
authors.lastname: Mendoza-Carrera
mesh_terms: D000293:Adolescent; D002097:C-Reactive Protein / Q000032:analysis; D002784:Cholesterol / Q000097:blood; D003430:Cross-Sectional Studies; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D006239:Haplotypes / Q000235:genetics; D006801:Humans; D006943:Hyperglycemia / Q000235:genetics*; D007328:Insulin / Q000097:blood; D015850:Interleukin-6 / Q000235:genetics*; D008297:Male; D008800:Mexico; D009765:Obesity / Q000235:genetics* / Q000378:metabolism; D011110:Polymorphism, Genetic; D014280:Triglycerides / Q000097:blood; D055815:Young Adult
chemical_list: C508600:IL6 protein, human; D007328:Insulin; D015850:Interleukin-6; D014280:Triglycerides; D002097:C-Reactive Protein; D002784:Cholesterol