title: Gut microbiota composition and activity in relation to host metabolic phenotype and disease risk.
abstract: The symbiotic gut microbiota modulate health and disease of the host through a series of transgenomic metabolic and immune regulatory axes. We explore connections between microbiome composition and function related to individual metabolic phenotypes and consider these interactions as possible targets for developing new personalized therapies and clinical management strategies.
authors.affiliation: Biomolecular Medicine, Department of Surgery and Cancer, Faculty of Medicine, Imperial College London, Sir Alexander Fleming Building, South Kensington, London SW7 2AZ, UK.
authors.forename: Elaine
authors.initials: E
authors.lastname: Holmes
authors.forename: Jia V
authors.initials: JV
authors.lastname: Li
authors.forename: Julian R
authors.initials: JR
authors.lastname: Marchesi
authors.forename: Jeremy K
authors.initials: JK
authors.lastname: Nicholson
mesh_terms: D000818:Animals; D001419:Bacteria / Q000378:metabolism*; D018407:Bacterial Physiological Phenomena; D044822:Biodiversity; D004032:Diet; D005767:Gastrointestinal Diseases / Q000517:prevention & control; D041981:Gastrointestinal Tract / Q000378:metabolism* / Q000382:microbiology*; D006801:Humans; D054892:Metagenome; D056186:Metagenomics; D010641:Phenotype