title: [Study on the diagnostic value of lung biopsy in hematologic patients with lung infection].
abstract: OBJECTIVE
  To evaluate the diagnostic value and safety of percutaneous lung biopsy in hematologic patients with lung infection.
  
  
  METHODS
  28 cases hematologic patients received CT-guided percutaneous lung biopsy when they developed a fever associated with pulmonary nodules or lumps in CT scan whose clinical diagnosis were unclear during or after chemotherapy. Sample of each lesion were drawn twice. The lung tissue was re-scanned after lung biopsy to check up in order to discover bleeding and pneumothorax. Biopsy tissue was examined by bacteria culture, acid-fast staining and pathology. Pathological examination contained HE staining, acid-fast stain, PAS stain, TB-DNA, methenamine silver and others.
  
  
  RESULTS
  28 cases contain 24 males and 4 females. Median age was 40 15 - 77 years old. Blood tests were as follows: 3 cases with HGB > 110 g/L, 9 with HGB 90 - 110 g/L, 12 with HGB 60 - 89 g/L, 4 with HGB < 60 g/L. 8 with WBC > 10×10(9)/L, 6 with WBC (4 - 10)×10(9)/L, 13 with WBC < 4×10(9)/L, 1 with WBC < 2×10(9)/L; 14 with PLT > 100×10(9)/L, 5 with PLT (50 - 100)×10(9)/L, 5 with PLT < 50×10(9)/L, 4 with PLT < 30×10(9)/L. 4 cases had mild extended PT, 3 mild extended APTT, 3 FIB lower than normal. Lung CT scans were as follows: 4 cases with simply lesion in right lung, 4 with simply lesion in left lung, 20 with lesions in bilateral lung. 8 cases were diagnosed as fungal infection, 3 as tuberculosis infection, 1 as lung cancer, 1 as pulmonary infiltration of lymphoma, 1 as pulmonary infiltration of leukemia, and 14 as inflammatory changes with no specific diagnosis. 4 cases came with pneumothorax during lung biopsy, mild to moderate in 3 cases and severe in 1 case. Severe patient turned better after CT-guided suction. 3 cases with mild hemoptysis turned better after treatment.
  
  
  CONCLUSIONS
  When hematopathy patients are with pulmonary nodules or lumps in CT scan whose clinical diagnosis is unclear, CT-guided percutaneous lung biopsy is safe and conducive to early diagnosis and conducive to early rehabilitation of patients if the coagulation function is basically normal and platelet count is not too low.
authors.affiliation: Department of Hematology, Henan Province People's Hospital, Zhengzhou, China.
authors.forename: Xiao-li
authors.initials: XL
authors.lastname: Yuan
authors.forename: Zun-min
authors.initials: ZM
authors.lastname: Zhu
authors.forename: Yin
authors.initials: Y
authors.lastname: Zhang
authors.forename: Peng-chong
authors.initials: PC
authors.lastname: Lei
authors.forename: Zhen
authors.initials: Z
authors.lastname: Wang
authors.forename: Jian-min
authors.initials: JM
authors.lastname: Guo
authors.forename: Jing
authors.initials: J
authors.lastname: Yang
authors.forename: Yu-zhu
authors.initials: YZ
authors.lastname: Zang
authors.forename: Zhong-wen
authors.initials: ZW
authors.lastname: Liu
authors.forename: Tong-bao
authors.initials: TB
authors.lastname: Wang
authors.forename: Yu-qing
authors.initials: YQ
authors.lastname: Chen
authors.forename: Bao-geng
authors.initials: BG
authors.lastname: Ma
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001706:Biopsy; D005260:Female; D006402:Hematologic Diseases / Q000382:microbiology / Q000473:pathology*; D006801:Humans; D008168:Lung / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D011014:Pneumonia / Q000175:diagnosis*; D055815:Young Adult