title: Live attenuated measles virus vaccine induces apoptosis and promotes             tumor regression in lung cancer.
abstract: Although the treatment of lung carcinoma has improved, at least 65% of patients             with this tumor succumb to progressive disease. Measles virus oncolytic therapy             has been reported to be effective in reducing tumor burden in immunocompetent             or nude mice; however, its potential to reduce tumor burden in lung carcinoma             remains to be determined. Herein, we report the potent antitumor effects of a             live attenuated measles vaccine virus Hu-191 strain (MV) against lung carcinoma.             Immunocompetent C57BL/6 mice bearing Lewis lung carcinoma (LLC) cells were treated             with MV (1x104 to 1x106 CCID50/ml) once every other day for 10 days. Our results             showed that treatment with MV effectively suppressed tumor growth and significantly             prolonged the survival time of tumor-bearing animals. Histological examination             revealed that the antitumor effects of MV therapy may result from increased induction             of apoptosis, tumor necrosis and elevated lymphocyte infiltration. Our data suggest             that MV, one of the widely used vaccines in China, has the ability to inhibit             the growth of mouse lung carcinoma and may prove useful in the further exploration             of the application of this approach in the treatment of human advanced lung cancer.
authors.affiliation: State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, West China Medical School, Sichuan University, Chengdu 610041, PR China.
authors.forename: Danhua
authors.initials: D
authors.lastname: Zhao
authors.forename: Ping
authors.initials: P
authors.lastname: Chen
authors.forename: Huiqiang
authors.initials: H
authors.lastname: Yang
authors.forename: Yonglin
authors.initials: Y
authors.lastname: Wu
authors.forename: Xianwu
authors.initials: X
authors.lastname: Zeng
authors.forename: Yu
authors.initials: Y
authors.lastname: Zhao
authors.forename: Yanjun
authors.initials: Y
authors.lastname: Wen
authors.forename: Xia
authors.initials: X
authors.lastname: Zhao
authors.forename: Xiaolin
authors.initials: X
authors.lastname: Liu
authors.forename: Yuquan
authors.initials: Y
authors.lastname: Wei
authors.forename: Yuhua
authors.initials: Y
authors.lastname: Li
mesh_terms: D000818:Animals; D017209:Apoptosis; D018827:Carcinoma, Lewis Lung / Q000473:pathology* / Q000517:prevention & control* / Q000821:virology; D049109:Cell Proliferation; D005260:Female; D005434:Flow Cytometry; D006801:Humans; D007124:Immunoenzyme Techniques; D008297:Male; D008457:Measles / Q000276:immunology / Q000517:prevention & control / Q000821:virology; D008458:Measles Vaccine / Q000627:therapeutic use*; D008459:Measles virus / Q000276:immunology*; D051379:Mice; D008810:Mice, Inbred C57BL; D008819:Mice, Nude; D050130:Oncolytic Virotherapy; D014407:Tumor Cells, Cultured; D014613:Vaccines, Attenuated; D023041:Xenograft Model Antitumor Assays
chemical_list: D008458:Measles Vaccine; D014613:Vaccines, Attenuated