title: Pd-catalyzed coupling reaction of fluorinated propargyl amidines with aryl iodides.
abstract: Catalyzed by ligand free Pd(OAc)(2), 2,5-disubstituted imidazole was prepared in good yield by the reaction of fluorinated propargyl amidines with iodoarene. Mechanistic studies indicated that this transformation occurs through a nitropalladation-reductive elimination pathway.
authors.affiliation: Key Laboratory of Organofluorine Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Road, Shanghai 200032, China.
authors.forename: Shan
authors.initials: S
authors.lastname: Li
authors.forename: Yafen
authors.initials: Y
authors.lastname: Yuan
authors.forename: Yajun
authors.initials: Y
authors.lastname: Li
authors.forename: Zhengke
authors.initials: Z
authors.lastname: Li
authors.forename: Lisi
authors.initials: L
authors.lastname: Zhang
authors.forename: Yongming
authors.initials: Y
authors.lastname: Wu
mesh_terms: D000578:Amidines / Q000737:chemistry*; D002384:Catalysis; D006847:Hydrocarbons, Iodinated / Q000737:chemistry*; D007093:Imidazoles / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D009942:Organometallic Compounds / Q000737:chemistry*; D010165:Palladium / Q000737:chemistry*
chemical_list: D000578:Amidines; D006847:Hydrocarbons, Iodinated; D007093:Imidazoles; D009942:Organometallic Compounds; D010165:Palladium