title: Catalytic enantioselective addition of terminal 1,3-diynes to N-sulfonyl aldimines: access to chiral diynylated carbinamines.
abstract: An efficient method for the asymmetric synthesis of chiral diynylated carbinamines is described. The direct catalytic enantioselective addition of terminal 1,3-diynes to N-sulfonyl aldimines proceeded smoothly under mild reaction conditions to produce diynylated carbinamines in up to 98% yield and 99% ee.
authors.affiliation: Department of Chemistry, Tianjin University, Tianjin 300072, China.
authors.forename: Tian-Lin
authors.initials: TL
authors.lastname: Liu
authors.forename: Heng-Xia
authors.initials: HX
authors.lastname: Zhang
authors.forename: Yan
authors.initials: Y
authors.lastname: Zheng
authors.forename: Qingwei
authors.initials: Q
authors.lastname: Yao
authors.forename: Jun-An
authors.initials: JA
authors.lastname: Ma
mesh_terms: D000480:Alkynes / Q000737:chemistry*; D002384:Catalysis; D007097:Imines / Q000737:chemistry*; D013237:Stereoisomerism; D013379:Substrate Specificity; D013450:Sulfones / Q000737:chemistry*
chemical_list: D000480:Alkynes; D007097:Imines; D013450:Sulfones