title: Diagnosing and staging of cystic echinococcosis: how do CT and MRI perform in comparison to ultrasound?
abstract: BACKGROUND
  Imaging plays the key role in diagnosing and staging of CE. The description of CE-specific imaging features and the WHO CE cyst classification is based on ultrasound. The reproducibility of the ultrasound-defined features of CE cysts is variable in MR- and CT-imaging. This is of particular importance for cysts that are not accessible by US and because of the increasing availability and overuse of CT and MR imaging.
  
  
  RESULTS
  Retrospective analysis of patients with abdominal CE cysts of an interdisciplinary CE clinic who had CT and/or MRI scans performed additionally to US imaging. All images were read and interpreted by the same senior radiologist experienced in the diagnosis of CE. US, CT and MR images were staged according to the WHO classification criteria. The agreement beyond chance was quantified by kappa coefficients (κ). 107 patients with 187 CE cysts met the inclusion criteria. All cysts were assessed by US, 138 by CT, and 125 by MRI. The level of agreement beyond chance of the individual CE stages 1-4 was clearly lower for CT, with κ ranging from 0.62 to 0.72, compared to MRI with values of κ between 0.83 and 1.0. For CE5 cysts CT (κ = 0.95) performed better than MRI (κ = 0.65).
  
  
  CONCLUSIONS
  Ultrasound remains the corner stone of diagnosis, staging and follow up of CE cysts. MRI reproduces the ultrasound-defined features of CE better than CT. If US cannot be performed due to cyst location or patient-specific reasons MRI with heavily T2-weighted series is preferable to CT.
authors.affiliation: Section Clinical Tropical Medicine, Department of Infectious Diseases, Heidelberg University Hospital, Heidelberg, Germany.
authors.forename: Marija
authors.initials: M
authors.lastname: Stojkovic
authors.forename: Kerstin
authors.initials: K
authors.lastname: Rosenberger
authors.forename: Hans-Ullrich
authors.initials: HU
authors.lastname: Kauczor
authors.forename: Thomas
authors.initials: T
authors.lastname: Junghanss
authors.forename: Waldemar
authors.initials: W
authors.lastname: Hosch
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D004443:Echinococcosis / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000473:pathology*; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D012720:Severity of Illness Index; D017906:Siphoviridae; D014057:Tomography, X-Ray Computed / Q000379:methods*; D014463:Ultrasonography / Q000379:methods*; D014481:United States; D055815:Young Adult