title: Sertraline concentrations and postmortem redistribution.
abstract: Sertraline is a commonly prescribed selective inhibitor of serotonin uptake used for the treatment of mental depression and anxiety. Central blood and liver concentrations of sertraline (norsertraline) are compared to levels in peripheral blood in nine medical examiner cases. Specimens were initially screened for alcohol and simple volatiles by GC-FID headspace analysis, ELISA for drugs of abuse, and alkaline drugs by GC/MS. Sertraline, when detected by the alkaline drug screen, was subsequently confirmed and quantified by a specific GC-NPD procedure. Data suggest that when ingested with other medications, sertraline may be a contributing factor in death. Sertraline (norsertraline) concentrations ranged from 0.13 (0.11) to 2.1 (6.0) mg/L in peripheral blood, from 0.18 (0.12) to 2.0 (6.7) mg/L in central blood, and 21 to 160 mg/kg in liver. Sertraline central blood to peripheral blood ratios averaged 1.22±0.85 (mean±standard deviation). The liver to peripheral blood ratios, on the other hand, were markedly higher and averaged 97±40 (mean±standard deviation). Given that a liver to peripheral blood ratio exceeding 20 is indicative of propensity for significant postmortem redistribution, these data confirm that sertraline is prone to marked postmortem redistribution.
authors.affiliation: Forensic Toxicology Division, County of San Diego Medical Examiner's Office, 5570 Overland Ave., Suite 101, San Diego, CA 92123, USA. Iain.McIntyre@sdcounty.ca.gov
authors.forename: Iain M
authors.initials: IM
authors.lastname: McIntyre
authors.forename: Phyllis
authors.initials: P
authors.lastname: Mallett
mesh_terms: D015057:1-Naphthylamine / Q000031:analogs & derivatives / Q000032:analysis / Q000493:pharmacokinetics; D000701:Analgesics, Opioid / Q000032:analysis / Q000493:pharmacokinetics; D000928:Antidepressive Agents / Q000032:analysis / Q000493:pharmacokinetics; D002492:Central Nervous System Depressants / Q000032:analysis / Q000493:pharmacokinetics; D002849:Chromatography, Gas; D004797:Enzyme-Linked Immunosorbent Assay; D000431:Ethanol / Q000032:analysis; D005410:Flame Ionization; D053593:Forensic Toxicology; D005766:Gastrointestinal Contents / Q000737:chemistry; D006801:Humans; D006993:Hypnotics and Sedatives / Q000032:analysis / Q000493:pharmacokinetics; D008099:Liver / Q000737:chemistry; D017367:Selective Serotonin Reuptake Inhibitors / Q000032:analysis* / Q000493:pharmacokinetics*; D020280:Sertraline / Q000032:analysis* / Q000493:pharmacokinetics* / Q000031:analogs & derivatives
chemical_list: D015057:1-Naphthylamine; D000701:Analgesics, Opioid; D000928:Antidepressive Agents; D002492:Central Nervous System Depressants; D000431:Ethanol; D006993:Hypnotics and Sedatives; D017367:Selective Serotonin Reuptake Inhibitors; D020280:Sertraline; C065162:desmethylsertraline