title: How to stop: the mysterious links among RNA polymerase II occupancy 3' of genes, mRNA 3' processing and termination.
abstract: Eukaryotic genes are transcribed by RNA polymerase II (RNAP II) through cycles of initiation, elongation and termination. Termination remains the least understood stage of transcription. Here we discuss the role of RNAP II occupancy downstream of the 3'ends of genes and its links with termination and mRNA 3' processing.
authors.affiliation: Institut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC), CNRS UMR 7104, INSERM U 964, Université de Strasbourg, Illkirch Cedex, France.
authors.forename: Krishanpal
authors.initials: K
authors.lastname: Anamika
authors.forename: Àkos
authors.initials: À
authors.lastname: Gyenis
authors.forename: Laszlo
authors.initials: L
authors.lastname: Tora
mesh_terms: D000818:Animals; D006657:Histones / Q000235:genetics / Q000378:metabolism; D006801:Humans; D026723:Polyadenylation; D012319:RNA Polymerase II / Q000378:metabolism*; D012323:RNA Processing, Post-Transcriptional; D012333:RNA, Messenger / Q000235:genetics* / Q000378:metabolism*; D061806:Transcription Termination, Genetic
chemical_list: D006657:Histones; D012333:RNA, Messenger; D012319:RNA Polymerase II
keywords: End of Annotated Gene; RNA Polymerase II pause; core histone genes; genome-wide mapping; polyadenylation; transcription termination