title: Abnormal amplitude low-frequency oscillations in medication-naive, first-episode patients with major depressive disorder: a resting-state fMRI study.
abstract: BACKGROUND
  Recent resting-state fMRI studies on major depressive disorder (MDD) have found altered temporal correlation between low-frequency oscillations (LFOs). However, changes on the amplitudes of these LFOs remain largely unknown.
  
  
  METHODS
  Twenty-two medication-naive, first-episode patients with MDD and 19 age-, sex-, education-matched healthy controls were recruited. Resting-state fMRI was obtained by using an echo-planar imaging sequence and the fractional amplitude of low-frequency fluctuations (fALFF) was calculated to investigate the amplitude of LFOs in the resting state.
  
  
  RESULTS
  Compared with control subjects, patients with MDD showed significantly decreased fALFF in right cerebellum posterior lobe, left parahippocampal gyrus and right middle frontal gyrus and increased fALFF in left superior occipital gyrus/cuneus (p<0.05, corrected for multiple comparisons). Further receiver operating characteristic curves (ROC) analyses suggested that the alterations of fALFF in these regions might be used as markers to classify patients with MDD from healthy controls.
  
  
  CONCLUSIONS
  These findings indicated LFOs abnormalities in MDD and the fALFF analysis might be a potential approach in further exploration of this disorder.
authors.affiliation: Key Laboratory for NeuroInformation of Ministry of Education, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, Sichuan 610054, China.
authors.forename: Feng
authors.initials: F
authors.lastname: Liu
authors.forename: Wenbin
authors.initials: W
authors.lastname: Guo
authors.forename: Ling
authors.initials: L
authors.lastname: Liu
authors.forename: Zhiliang
authors.initials: Z
authors.lastname: Long
authors.forename: Chaoqiong
authors.initials: C
authors.lastname: Ma
authors.forename: Zhimin
authors.initials: Z
authors.lastname: Xue
authors.forename: Yifeng
authors.initials: Y
authors.lastname: Wang
authors.forename: Jun
authors.initials: J
authors.lastname: Li
authors.forename: Maorong
authors.initials: M
authors.lastname: Hu
authors.forename: Jianwei
authors.initials: J
authors.lastname: Zhang
authors.forename: Handan
authors.initials: H
authors.lastname: Du
authors.forename: Ling
authors.initials: L
authors.lastname: Zeng
authors.forename: Zhening
authors.initials: Z
authors.lastname: Liu
authors.forename: Sarah C
authors.initials: SC
authors.lastname: Wooderson
authors.forename: Changlian
authors.initials: C
authors.lastname: Tan
authors.forename: Jingping
authors.initials: J
authors.lastname: Zhao
authors.forename: Huafu
authors.initials: H
authors.lastname: Chen
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D002531:Cerebellum / Q000502:physiology; D003865:Major Depressive Disorder / Q000503:physiopathology*; D017352:Echo-Planar Imaging; D005260:Female; D005625:Frontal Lobe / Q000502:physiology; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D009778:Occipital Lobe / Q000502:physiology; D020534:Parahippocampal Gyrus / Q000502:physiology; D055815:Young Adult