title: [Expression of ADAMTS-2 and TGF-β1 in cirrhotic liver].
abstract: OBJECTIVE
  To explore the expression and distribution of a disintegrin and metalloprotease with thrombospondin motif (ADAMTS)-2 and transforming growth factor (TGF) -β1 in patients with or without cirrhosis, and to determine their relation.
  
  
  METHODS
  The liver tissues from 16 patients with cirrhotic portal hypertensive and 8 patients with liver injury were collected in Wuhan General Hospital from March to June, 2010. Immunohistochemistry and Western blot were applied to detect the protein expression of ADAMTS-2 and TGF-β1.
  
  
  RESULTS
  Immunohistochemistry showed that the expression of ADAMTS-2 and TGF-β1 was significantly higher in the cirrhotic tissues than that in normal tissues (P<0.05). Western blot also showed the expression of ADAMTS-2 and TGF-β1 in the cirrhosis tissues was significantly higher than that in normal tissues (P<0.05). There was a positive correlation between ADAMTS-2 and TGF-β1 (r=0.862, P<0.01).
  
  
  CONCLUSIONS
  ADAMTS-2 and TGF-β1 may have a synergistic reaction in promoting liver cirrhosis.
authors.affiliation: Department of General Surgery, Wuhan General Hospital of Guangzhou Military, Wuhan, China.
authors.forename: Hanjun
authors.initials: H
authors.lastname: Li
authors.forename: Chao
authors.initials: C
authors.lastname: Dong
authors.forename: Tingjia
authors.initials: T
authors.lastname: Cao
authors.forename: Shi
authors.initials: S
authors.lastname: Chang
mesh_terms: D051722:ADAM Proteins / Q000378:metabolism*; D000071096:ADAMTS Proteins; D000071121:ADAMTS4 Protein; D015153:Blotting, Western; D006801:Humans; D007150:Immunohistochemistry; D008099:Liver / Q000378:metabolism* / Q000473:pathology; D008103:Liver Cirrhosis / Q000378:metabolism*; D011348:Procollagen N-Endopeptidase / Q000378:metabolism*; D053773:Transforming Growth Factor beta1 / Q000378:metabolism*
chemical_list: C508960:TGFB1 protein, human; D053773:Transforming Growth Factor beta1; D051722:ADAM Proteins; D000071096:ADAMTS Proteins; C000609307:ADAMTS2 protein, human; D011348:Procollagen N-Endopeptidase; D000071121:ADAMTS4 Protein