title: Specific genetic polymorphisms of IL10-592 AA and IL10-819 TT genotypes lead to the key role for inducing docetaxel-induced liver injury in breast cancer patients.
abstract: OBJECTIVE
  This study was designed to explore the genetic polymorphism of IL-10 (-1082A/G, -592A/C, -819T/C), TNF-α (-308G/A) with susceptibility to docetaxel-induced liver injury (DILI) in Chinese breast cancer patients.
  
  
  METHODS
  The targeted genetic polymorphisms of IL10-1082G/A, IL10-592A/C, IL10-819T/C, TNF-308G/A from 40 patients with DILI were assayed by matrix-assisted laser desorption/ionization-time of flight of Sequenom.
  
  
  RESULTS
  AA genotype of IL10-592 and TT of IL10-819 significantly increased incidence of DILI (P = 0.005, OR = 3.137). No differences of TNF gene polymorphism between the two groups were seen.
  
  
  CONCLUSIONS
  The genetic polymorphism of the IL10-592A/C AA genotype and IL10-819T/C TT genotype was predominantly conferred to the incidence of docetaxel-induced liver injury.
authors.affiliation: Department of Medical Oncology, Peking University Cancer Hospital and Institute, Beijing, China.
authors.forename: Xu
authors.initials: X
authors.lastname: Liang
authors.forename: Jie
authors.initials: J
authors.lastname: Zhang
authors.forename: Yulin
authors.initials: Y
authors.lastname: Zhu
authors.forename: Yuanli
authors.initials: Y
authors.lastname: Lu
authors.forename: Xinna
authors.initials: X
authors.lastname: Zhou
authors.forename: Zheng
authors.initials: Z
authors.lastname: Wang
authors.forename: Jing
authors.initials: J
authors.lastname: Yu
authors.forename: Ying
authors.initials: Y
authors.lastname: Yan
authors.forename: Lijun
authors.initials: L
authors.lastname: Di
authors.forename: Li
authors.initials: L
authors.lastname: Che
authors.forename: Hanfang
authors.initials: H
authors.lastname: Jiang
authors.forename: Bin
authors.initials: B
authors.lastname: Shao
authors.forename: Xiaoli
authors.initials: X
authors.lastname: Wang
authors.forename: Huabing
authors.initials: H
authors.lastname: Yang
authors.forename: Herbert Kim
authors.initials: HK
authors.lastname: Lyerly
authors.forename: Jun
authors.initials: J
authors.lastname: Ren
mesh_terms: D000328:Adult; D000368:Aged; D000970:Antineoplastic Agents / Q000009:adverse effects* / Q000627:therapeutic use; D001943:Breast Neoplasms / Q000188:drug therapy* / Q000235:genetics; D016022:Case-Control Studies; D056486:Chemical and Drug Induced Liver Injury / Q000453:epidemiology / Q000235:genetics*; D000077143:Docetaxel; D005260:Female; D005787:Gene Frequency; D006801:Humans; D016753:Interleukin-10 / Q000235:genetics*; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide / Q000502:physiology; D043823:Taxoids / Q000009:adverse effects* / Q000627:therapeutic use; D014409:Tumor Necrosis Factor-alpha / Q000235:genetics
chemical_list: D000970:Antineoplastic Agents; C508609:IL10 protein, human; D043823:Taxoids; D014409:Tumor Necrosis Factor-alpha; D016753:Interleukin-10; D000077143:Docetaxel