title: Mapping repetition suppression of the P50 evoked response to the human cerebral cortex.
abstract: OBJECTIVE
  The cerebral network subserving repetition suppression (RS) of the P50 auditory evoked response as observed using paired-identical-stimulus (S1-S2) paradigms is not well-described.
  
  
  METHODS
  We analyzed S1-S2 data from electrodes placed on the cortices of 64 epilepsy patients. We identified regions with maximal amplitude responses to S1 (i.e., stimulus registration), regions with maximal suppression of responses to S2 relative to S1 (i.e., RS), and regions with no or minimal RS 30-80 ms post stimulation.
  
  
  RESULTS
  Several temporal, parietal and cingulate area regions were shown to have significant initial registration activity (i.e., strong P50 response to S1). Moreover, prefrontal, cingulate, and parietal lobe regions not previously proposed to be part of the P50 habituation neural circuitry were found to exhibit significant RS.
  
  
  CONCLUSIONS
  The data suggest that the neural network underlying the initial phases of the RS process may include regions not previously thought to be involved like the parietal and cingulate cortexes. In addition, a significant role for the frontal lobe in mediating this function is supported.
  
  
  CONCLUSIONS
  A number of regions of interest are identified through invasive recording that will allow further probing of the RS function using less invasive technology.
authors.affiliation: Wayne State University, School of Medicine, Department of Psychiatry and Behavioral Neurosciences, Detroit, MI, USA. nboutros@med.wayne.edu
authors.forename: Nash N
authors.initials: NN
authors.lastname: Boutros
authors.forename: Klevest
authors.initials: K
authors.lastname: Gjini
authors.forename: Simon B
authors.initials: SB
authors.lastname: Eickhoff
authors.forename: Horst
authors.initials: H
authors.lastname: Urbach
authors.forename: Mark E
authors.initials: ME
authors.lastname: Pflieger
mesh_terms: D000161:Acoustic Stimulation; D000328:Adult; D000368:Aged; D001931:Brain Mapping; D002540:Cerebral Cortex / Q000033:anatomy & histology / Q000502:physiology*; D004351:Drug Resistance; D004567:Electrodes, Implanted; D004569:Electroencephalography; D004828:Epilepsies, Partial / Q000188:drug therapy / Q000503:physiopathology / Q000601:surgery; D005072:Evoked Potentials, Auditory / Q000502:physiology*; D005260:Female; D006179:Gyrus Cinguli / Q000502:physiology; D006185:Habituation, Psychophysiologic; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D019635:Neurosurgical Procedures; D010296:Parietal Lobe / Q000502:physiology; D017397:Prefrontal Cortex / Q000502:physiology; D055139:Sensory Gating / Q000502:physiology; D012815:Signal Processing, Computer-Assisted; D055815:Young Adult