title: Sensing proteins through nanopores: fundamental to applications.
abstract: Proteins subjected to an electric field and forced to pass through a nanopore induce blockades of ionic current that depend on the protein and nanopore characteristics and interactions between them. Recent advances in the analysis of these blockades have highlighted a variety of phenomena that can be used to study protein translocation and protein folding, to probe single-molecule catalytic reactions in order to obtain kinetic and thermodynamic information, and to detect protein-antibody complexes, proteins with DNA and RNA aptamers, and protein-pore interactions. Nanopore design is now well controlled, allowing the development of future biotechnologies and medicine applications.
authors.affiliation: CNRS-UMR 8587, LAMBE, Université de Cergy-Pontoise et Université d'Evry, France.
authors.forename: Abdelghani
authors.initials: A
authors.lastname: Oukhaled
authors.forename: Laurent
authors.initials: L
authors.lastname: Bacri
authors.forename: Manuela
authors.initials: M
authors.lastname: Pastoriza-Gallego
authors.forename: Jean-Michel
authors.initials: JM
authors.lastname: Betton
authors.forename: Juan
authors.initials: J
authors.lastname: Pelta
mesh_terms: D032701:Biomimetics; D058608:Nanopores; D017510:Protein Folding; D021381:Protein Transport; D011506:Proteins / Q000032:analysis*
chemical_list: D011506:Proteins