title: Risk factors for gastrointestinal tract colonization with extended-spectrum β-lactamase (ESBL)-producing Escherichia coli and Klebsiella species in hospitalized patients.
abstract: We describe the prevalence of and risk factors for colonization with extended-spectrum β-lactamase (ESBL)-producing Escherichia coli and Klebsiella species (ESBL-EK) in hospitalized patients. The prevalence of colonization with ESBL-EK was 2.6%. Colonization was associated with cirrhosis, longer duration of hospital stay prior to surveillance, and prior exposure to clindamycin or meropenem.
authors.affiliation: Division of Infectious Diseases, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA. jennifer.han@uphs.upenn.edu
authors.forename: Jennifer H
authors.initials: JH
authors.lastname: Han
authors.forename: Irving
authors.initials: I
authors.lastname: Nachamkin
authors.forename: Theoklis E
authors.initials: TE
authors.lastname: Zaoutis
authors.forename: Susan E
authors.initials: SE
authors.lastname: Coffin
authors.forename: Darren R
authors.initials: DR
authors.lastname: Linkin
authors.forename: Neil O
authors.initials: NO
authors.lastname: Fishman
authors.forename: Mark G
authors.initials: MG
authors.lastname: Weiner
authors.forename: Baofeng
authors.initials: B
authors.lastname: Hu
authors.forename: Pam
authors.initials: P
authors.lastname: Tolomeo
authors.forename: Ebbing
authors.initials: E
authors.lastname: Lautenbach
mesh_terms: D000328:Adult; D000368:Aged; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D002353:Carrier State / Q000453:epidemiology* / Q000382:microbiology; D016022:Case-Control Studies; D002981:Clindamycin / Q000627:therapeutic use; D004926:Escherichia coli / Q000201:enzymology*; D005260:Female; D041981:Gastrointestinal Tract / Q000382:microbiology*; D006801:Humans; D007709:Klebsiella / Q000201:enzymology*; D007902:Length of Stay; D008103:Liver Cirrhosis / Q000453:epidemiology; D008297:Male; D000077731:Meropenem; D008826:Microbial Sensitivity Tests; D008875:Middle Aged; D015995:Prevalence; D012007:Rectum / Q000382:microbiology; D012307:Risk Factors; D013845:Thienamycins / Q000627:therapeutic use; D018440:beta-Lactam Resistance; D001618:beta-Lactamases / Q000096:biosynthesis*
chemical_list: D000900:Anti-Bacterial Agents; D013845:Thienamycins; D002981:Clindamycin; D001618:beta-Lactamases; D000077731:Meropenem