title: Detoxifying emulsion for overdosed aspirin intoxication.
abstract: Aspirin overdose could lead to intoxication, with the clinical manifestations of vomit, pulmonary edema and severe dyspnea. Stomach washing, emetics and activated charcoal are the common treatments with a limited efficiency for the intoxication. In this study, an active emulsion for aspirin intoxication was prepared with the detoxifying efficiency of 100% in less than 15 min, with the conditions of dodecane used as the oil phase, 8% Abil EM90 as the surfactant and 0.1 mol/L sodium hydroxide as the inner aqueous phase in a volume ratio of 2 between internal aqueous phase and the oil phase.
authors.affiliation: Laboratoire de Génie des Procédés et Matériaux, Ecole Centrale Paris, 92295 Châtenay-Malabry, France. belindawj@gmail.com
authors.forename: Wenjun
authors.initials: W
authors.lastname: Zhang
authors.forename: Moncef
authors.initials: M
authors.lastname: Stambouli
authors.forename: Dominique
authors.initials: D
authors.lastname: Pareau
mesh_terms: D000473:Alkanes / Q000737:chemistry; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage / Q000506:poisoning*; D000931:Antidotes / Q000737:chemistry / Q000494:pharmacology*; D001241:Aspirin / Q000008:administration & dosage / Q000506:poisoning*; D062787:Drug Overdose; D004655:Emulsions; D012972:Sodium Hydroxide / Q000737:chemistry; D013997:Time Factors; D014297:Trimethylsilyl Compounds / Q000737:chemistry
chemical_list: C582464:Abil EM90; D000473:Alkanes; D000894:Anti-Inflammatory Agents, Non-Steroidal; D000931:Antidotes; D004655:Emulsions; D014297:Trimethylsilyl Compounds; C007548:n-dodecane; D012972:Sodium Hydroxide; D001241:Aspirin