title: Protective effects of methylsulfonylmethane on hemodynamics and oxidative stress in monocrotaline-induced pulmonary hypertensive rats.
abstract: Methylsulfonylmethane (MSM) is naturally occurring organic sulfur that is known as a potent antioxidant/anti-inflammatory compound. The aim of this study was to investigate the effect of MSM on hemodynamics functions and oxidative stress in rats with monocrotaline- (MCT-) induced pulmonary arterial hypertension (PAH). Wistar rats were randomly assigned to 38-days treatment. MSM was administered to rats at 100, 200, and 400 mg/kg/day doses 10 days before a single dose of 60 mg/kg, IP, MCT. Hemodynamics of ventricles were determined by Powerlab AD instrument. Blood samples were obtained to evaluate changes in the antioxidative system including activities of catalase (CAT), superoxide dismutase (SOD), glutathione peroxidase (GPx), and the level of reduced glutathione (GSH) and malondialdehyde (MDA). Improvements in cardiopulmonary hemodynamics were observed in the MSM-treated pulmonary arterial hypertensive rats, with a significant reduction in right ventricular systolic pressure (RSVP) and an increase in the mean arterial pressure (MAP). The values of CAT, SOD, GSH-px activities, and GSH were significantly lower in MCT-induced PAH (P < 0.01), but they were recovered to control levels of MSM-treated groups. Our present results suggest that long-term administration of the MSM attenuates MCT-induced PAH in rats through modulation of oxidative stress and antioxidant defense.
authors.affiliation: Department of Pharmacology and Toxicology, School of Pharmacy, Tabriz University of Medical Sciences, Tabriz 5165665931, Iran ; Division of Molecular Toxicology, Institute of Environmental Medicine, Karolinska Institutet (KI), Box 210, 17177 Stockholm, Sweden ; Department of Pharmacology and Physiology, School of Medicine, Ardabil University of Medical Sciences, Ardabil 56135665, Iran.
authors.forename: Sadollah
authors.initials: S
authors.lastname: Mohammadi
authors.forename: Moslem
authors.initials: M
authors.lastname: Najafi
authors.forename: Hossein
authors.initials: H
authors.lastname: Hamzeiy
authors.forename: Nasrin
authors.initials: N
authors.lastname: Maleki-Dizaji
authors.forename: Masoud
authors.initials: M
authors.lastname: Pezeshkian
authors.forename: Homayon
authors.initials: H
authors.lastname: Sadeghi-Bazargani
authors.forename: Masoud
authors.initials: M
authors.lastname: Darabi
authors.forename: Sara
authors.initials: S
authors.lastname: Mostafalou
authors.forename: Shahab
authors.initials: S
authors.lastname: Bohlooli
authors.forename: Alireza
authors.initials: A
authors.lastname: Garjani