title: Study on application of optical clearing technique in skin diseases.
abstract: So far, the study of the optical clearing is almost always about healthy tissue. However, the ultimate goal is to detect diseases for clinical application. Optical clearing on diseased skins is explored. The effect is evaluated by applying a combined liquid paraffin and glycerol mixed solution on several kinds of diseased skins in vitro. Scanning experiments from optical coherence tomography show that it has different effects among fibroma, pigmented nevus, and seborrheic keratosis. Based on the results, we conclude that different skin diseases have different compositions and structures, and their optical parameters and biological characteristics should be different, which implies that the optical clearing technique may have selectivity and may not be suitable for all kinds of skin diseases.
authors.affiliation: Nankai University, Institute of Modern Optics, Key Laboratory of Optical Information Science and Technology, Ministry of Education, Tianjin 300071, China.
authors.forename: Hao
authors.initials: H
authors.lastname: Shan
authors.forename: Yanmei
authors.initials: Y
authors.lastname: Liang
authors.forename: Jingyi
authors.initials: J
authors.lastname: Wang
authors.forename: Yan
authors.initials: Y
authors.lastname: Li
mesh_terms: D004814:Epidermal Cyst / Q000175:diagnosis; D005350:Fibroma / Q000175:diagnosis; D005990:Glycerol; D006391:Hemangioma / Q000175:diagnosis; D006801:Humans; D017492:Keratosis, Seborrheic / Q000175:diagnosis; D008899:Mineral Oil; D009508:Nevus, Pigmented / Q000175:diagnosis; D055620:Optical Phenomena; D012031:Refractometry; D012542:Scattering, Radiation; D012871:Skin Diseases / Q000175:diagnosis*; D012878:Skin Neoplasms / Q000175:diagnosis; D012996:Solutions; D041623:Tomography, Optical Coherence / Q000379:methods*
chemical_list: D012996:Solutions; D008899:Mineral Oil; D005990:Glycerol