title: Immunological and biochemical markers in preeclampsia.
abstract: A basic precondition for the development of preeclampsia is the presence of placental trophoblast cells in the maternal blood circulation. On the other hand, while trophoblast cells are present in the blood of all pregnant women, preeclampsia occurs in only 2-5% of them. Evidently, other factors play a crucial role. The aim of this study was to compare a set of selected immunological factors (anti-cardiolipin autoantibodies, trophoblast-induced cell-mediated immunity, C3 and C4 complement components) and biochemical factors (serum immunoglobulins IgA, IgG, IgM) among three groups of women with uncomplicated pregnancy, gestational hypertension, or preeclampsia. Blood samples were taken 2-12h before delivery. In the preeclampsia group, there was a significantly higher number of women positive for anti-cardiolipin autoantibodies, trophoblast-induced cell-mediated immunity was elevated, serum IgG was elevated and C4 complement component was reduced. We conclude that both elevated autoimmune reactivity and the higher immune reactivity to trophoblast may contribute to the onset of preeclampsia.
authors.affiliation: Institute for the Care of Mother and Child, Prague, Czech Republic.
authors.forename: A
authors.initials: A
authors.lastname: Kestlerová
authors.forename: J
authors.initials: J
authors.lastname: Feyereisl
authors.forename: V
authors.initials: V
authors.lastname: Frisová
authors.forename: A
authors.initials: A
authors.lastname: Měchurová
authors.forename: K
authors.initials: K
authors.lastname: Šůla
authors.forename: T
authors.initials: T
authors.lastname: Zima
authors.forename: J
authors.initials: J
authors.lastname: Běláček
authors.forename: J
authors.initials: J
authors.lastname: Madar
mesh_terms: D000328:Adult; D001323:Autoantibodies / Q000276:immunology*; D015415:Biomarkers / Q000378:metabolism; D002308:Cardiolipins / Q000276:immunology; D003176:Complement C3 / Q000378:metabolism; D003181:Complement C4 / Q000378:metabolism*; D005260:Female; D006801:Humans; D007111:Immunity, Cellular; D007136:Immunoglobulins / Q000097:blood; D011225:Pre-Eclampsia / Q000175:diagnosis / Q000276:immunology*; D011247:Pregnancy; D014327:Trophoblasts / Q000276:immunology*; D055815:Young Adult
chemical_list: D001323:Autoantibodies; D015415:Biomarkers; D002308:Cardiolipins; D003176:Complement C3; D003181:Complement C4; D007136:Immunoglobulins