title: Validation and proposals for a refinement of the WHO 2008 classification of myelodysplastic syndromes without excess of blasts.
abstract: In 2008, the WHO proposed changes in the classification of MDS regarding RCUD and MDS unclassifiable. We validated these proposals by using 2032 patients of the Düsseldorf MDS Registry. 10% of the patients had RCUD and 6% MDS-U. Among patients with RCUD, only 9% had RN and 6% had RT. There was no correlation between dysplastic cell line and type of cytopenia. There was no difference in prognosis between RCMD and MDS-U and between RA, RT, and RN. The separation of RA, RN, and RT is not justified suggesting a consolidation as RCUD. MDS-U should be integrated into RCMD.
authors.affiliation: Department of Hematology, Oncology and Clinical Immunology, Heinrich-Heine-University, Düsseldorf, Germany.
authors.forename: Anna
authors.initials: A
authors.lastname: Maassen
authors.forename: Corinna
authors.initials: C
authors.lastname: Strupp
authors.forename: Aristoteles
authors.initials: A
authors.lastname: Giagounidis
authors.forename: Andrea
authors.initials: A
authors.lastname: Kuendgen
authors.forename: Kathrin
authors.initials: K
authors.lastname: Nachtkamp
authors.forename: Barbara
authors.initials: B
authors.lastname: Hildebrandt
authors.forename: Norbert
authors.initials: N
authors.lastname: Gattermann
authors.forename: Carlo
authors.initials: C
authors.lastname: Aul
authors.forename: Rainer
authors.initials: R
authors.lastname: Haas
authors.forename: Ulrich
authors.initials: U
authors.lastname: Germing
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D006801:Humans; D008875:Middle Aged; D009190:Myelodysplastic Syndromes / Q000145:classification* / Q000401:mortality; D011379:Prognosis; D012189:Retrospective Studies; D014944:World Health Organization